title: Characteristics of B-cell lymphomas in HIV/HCV-coinfected patients during the combined antiretroviral therapy era: an ANRS CO16 LYMPHOVIR cohort study.
abstract: Hepatitis C virus (HCV) infection is frequent among HIV-infected patients. We describe, the characteristics of 6 HIV/HCV-coinfected patients with B-cell non-Hodgkin lymphoma (NHL) included in a prospective cohort study of HIV-related lymphomas. Five of the 6 cases had features of marginal zone/lymphoplasmacytic NHL versus 1 of 33 HIV only-infected patients. Remarkably, anti-HCV treatment led to a hematological response in a patient with splenic marginal zone lymphoma. This supports the role of chronic antigenic stimulation by HCV on lymphomagenesis and further evaluation of HCV antiviral therapy in coinfected patients with NHL.
authors: Department of Internal Medicine II, Université Paris 6 Pierre et Marie Curie UMR S 943, Paris, France.
authors: Benjamin
authors: B
authors: Terrier
authors: Dominique
authors: D
authors: Costagliola
authors: Sophie
authors: S
authors: Prevot
authors: Houria
authors: H
authors: Chavez
authors: Pascale
authors: P
authors: Missy
authors: Patricia
authors: P
authors: Rince
authors: Regis
authors: R
authors: Costello
authors: Lelia
authors: L
authors: Escaut
authors: Jean
authors: J
authors: Gabarre
authors: Bertrand
authors: B
authors: Joly
authors: Lorraine
authors: L
authors: Letranchant
authors: Steven
authors: S
authors: Le Gouill
authors: Pascale
authors: P
authors: Morineau-Le Houssine
authors: Anne
authors: A
authors: Simon
authors: Danielle
authors: D
authors: Canioni
authors: Olivier
authors: O
authors: Hermine
authors: Patrice
authors: P
authors: Cacoub
authors: Yassine
authors: Y
authors: Taoufik
authors: Martine
authors: M
authors: Raphael
authors: Caroline
authors: C
authors: Besson
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D015331:Cohort Studies; D060085:Coinfection; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D016174:Hepacivirus / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000150:complications* / Q000276:immunology; D016393:Lymphoma, B-Cell / Q000150:complications / Q000276:immunology / Q000821:virology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D000914:Antibodies, Viral