title: Interferon-alpha for IgM nephropathy?
abstract: Immunoglobulin M (IgM) nephropathy is an idiopathic glomerulonephritis characterized by mesangial deposits of IgM. IgM nephropathy presenting with proteinuria, especially nephrotic syndrome, frequently is steroid-dependent or steroidresistant and associated with reaching endstage renal disease after a 15-year follow-up. Because no long-term effective treatment is known for patients with IgM nephropathy, there is a clear need for therapeutic alternatives. We describe a patient with IgM nephropathy represented by recurrence of nephrotic syndrome who achieved longterm remission with interferon-alpha sustained treatment.
authors: Sha
authors: S
authors: Liu
authors: Dongliang
authors: D
authors: Zhang
authors: Qidong
authors: Q
authors: Zhang
authors: Wenhu
authors: W
authors: Liu
mesh_terms: D000328:Adult; D001706:Biopsy; D005921:Glomerulonephritis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007155:Immunologic Factors / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D012008:Recurrence
chemical_list: D007075:Immunoglobulin M; D007155:Immunologic Factors; D016898:Interferon-alpha