title: Hydrogen peroxide detection in wet air with a Prussian Blue based solid salt bridged three electrode system.
abstract: We report on a novel electroanalytical system for hydrogen peroxide (H2O2) detection in humidity or droplets of aerosol, formed by air bubbling through a washing chamber; the resulting flow mimics the exhaled human breath. The system is based on a planar three-electrode structure (with a Prussian Blue based H2O2 transducer modified working electrode) bridged by a solid salt-saturated filament material (filter paper, cotton textile). Respective to the hydrogen peroxide content in the washing valve, the response of the aerosol-sensing system is linear in the concentration range of 0.1-10 μM, which overlaps the generally accepted H2O2 content in exhaled breath condensate (EBC), with the sensitivity of 8 A M(-1) cm(-2). The response to the upper limit of the calibration range is stable for more than 50 injection cycles recorded within 3 days. Both the stability and the suitable calibration range allow one to consider the reported aerosol-sensing system as a prototype for a simple (avoiding intermediate EBC collection) noninvasive diagnostic tool for pulmonary patients.
authors: Maria A
authors: MA
authors: Komkova
authors: Elena E
authors: EE
authors: Karyakina
authors: Frank
authors: F
authors: Marken
authors: Arkady A
authors: AA
authors: Karyakin
mesh_terms: D000388:Air; D001944:Breath Tests; D004563:Electrochemistry / Q000295:instrumentation*; D004566:Electrodes; D005295:Ferrocyanides / Q000737:chemistry*; D006813:Humidity; D006861:Hydrogen Peroxide / Q000032:analysis* / Q000737:chemistry; D057230:Limit of Detection; D012492:Salts / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D005295:Ferrocyanides; D012492:Salts; D014867:Water; D006861:Hydrogen Peroxide; C000170:ferric ferrocyanide