title: Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells.
abstract: A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.
authors: Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
authors: Kyoung-Ran
authors: KR
authors: Kim
authors: Da-Rae
authors: DR
authors: Kim
authors: Taemin
authors: T
authors: Lee
authors: Ji Young
authors: JY
authors: Yhee
authors: Byeong-Su
authors: BS
authors: Kim
authors: Ick Chan
authors: IC
authors: Kwon
authors: Dae-Ro
authors: DR
authors: Ahn
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D002232:Carbocyanines / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D049329:Nanostructures / Q000737:chemistry / Q000633:toxicity
chemical_list: D002232:Carbocyanines; D004337:Drug Carriers; C085321:cyanine dye 5; D004317:Doxorubicin; D004247:DNA