title: Comparison of the effects of atropine and labetalol on trigeminocardiac reflex-induced hemodynamic alterations during percutaneous microballoon compression of the trigeminal ganglion.
abstract: BACKGROUND
  A significant abrupt drop in heart rate is the most frequent complication during percutaneous microballoon compression of the trigeminal ganglion. It is suggested that co-activation of the sympathetic and parasympathetic nervous systems plays an important role in this occurrence. We hypothesized that not only atropine, but also labetalol might be effective in preventing this cardiovascular reflex during percutaneous microballoon compression of the trigeminal ganglion.
  
  
  METHODS
  Patients who underwent percutaneous microballoon compression for trigeminal neuralgia between September 2007 and December 2009 were prospectively evaluated. The relationship between the hemodynamic changes and intraoperative use of atropine (0.01 mg/kg) or labetalol (0.05 mg/kg) was compared. One-way analysis of variance with Bartlett's and Tukey's post-tests was used, and a value of p < 0.05 was considered statistically significant.
  
  
  RESULTS
  In total, 119 patients who received percutaneous microballoon compression for trigeminal neuralgia were studied, of whom 38 received atropine before ganglion compression, 36 received labetalol, and 45 received normal saline as a control. Of the patients who received normal saline, 31.3% had moderate bradycardia (heart rate < 50 beats/min), 13.3% had severe bradycardia (heart rate < 40 beats/min), and 7% had arrhythmia. Of the patients who received atropine, 7.8% had moderate bradycardia, 7.8% had arrhythmia, and 5.3% had postcompression tachycardia by the end of ganglion compression. Of the patients who received labetalol, 16.7% had moderate bradycardia, 5.6% had severe bradycardia, and 2.8% had arrhythmia. Systemic blood pressure was markedly elevated straight after compression in all groups and tended to normalize 3 minutes afterwards.
  
  
  CONCLUSIONS
  Both atropine and labetalol were able to lower the frequency of bradycardia. Neither of them could abolish episodes of bradycardia during the procedure. Patients receiving labetalol before microballoon compression were subject to a smaller change in hemodynamics. Our findings verified that the sympathetic and parasympathetic nervous systems may be involved in the complex interneuronal interaction of the trigeminocardiac reflex.
authors: Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.
authors: Chun-Yu
authors: CY
authors: Chen
authors: Chiao-Fen
authors: CF
authors: Luo
authors: Yi-Chun
authors: YC
authors: Hsu
authors: Jyi-Feng
authors: JF
authors: Chen
authors: Yuan-Ji
authors: YJ
authors: Day
mesh_terms: D000328:Adult; D000368:Aged; D001285:Atropine / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007741:Labetalol / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D059230:Reflex, Trigeminocardiac / Q000502:physiology*; D012668:Trigeminal Ganglion / Q000503:physiopathology*; D014277:Trigeminal Neuralgia / Q000628:therapy*
chemical_list: D001285:Atropine; D007741:Labetalol