title: Attenuation of spinal cord injury-induced astroglial and microglial activation by repetitive transcranial magnetic stimulation in rats.
abstract: Spinal cord injury (SCI) causes not only loss of sensory and motor function below the level of injury but also chronic pain, which is difficult and challenging of the treatment. Repetitive transcranial magnetic stimulation (rTMS) to the motor cortex, of non-invasive therapeutic methods, has the motor and sensory consequences and modulates pain in SCI-patients. In the present study, we studied the effectiveness of rTMS and the relationship between the modulation of pain and the changes of neuroglial expression in the spinal cord using a rat SCI-induced pain model. Elevated expressions of Iba1 and GFAP, specific microglial and astrocyte markers, was respectively observed in dorsal and ventral horns at the L4 and L5 levels in SCI rats. But in SCI rats treated with 25 Hz rTMS for 8 weeks, these expressions were significantly reduced by about 30%. Our finding suggests that this attenuation of activation by rTMS is related to pain modulation after SCI. Therefore, rTMS might provide an alternative means of attenuating neuropathic pain below the level of SCI.
authors: Clinical Trial Center for Medical Devices of Yeungnam University Hospital, Daegu, Korea.
authors: Ji Young
authors: JY
authors: Kim
authors: Gyu-Sik
authors: GS
authors: Choi
authors: Yun-Woo
authors: YW
authors: Cho
authors: Heekyung
authors: H
authors: Cho
authors: Se-Jin
authors: SJ
authors: Hwang
authors: Sang-Ho
authors: SH
authors: Ahn
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism; D017628:Microglia / Q000166:cytology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009437:Neuralgia / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000150:complications / Q000473:pathology / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation
chemical_list: C100745:Aif1 protein, rat; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins
keywords: Astrocytes; Microglia; Repetitive Transcranial Magnetic Stimulation; Spinal Cord Injury
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