title: Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1.
abstract: We identify an Arabidopsis pyridoxal-phosphate-dependent aminotransferase, VAS1, whose loss-of-function simultaneously increases amounts of the phytohormone auxin and the ethylene precursor 1-aminocyclopropane-1-carboxylate. VAS1 uses the ethylene biosynthetic intermediate methionine as an amino donor and the auxin biosynthetic intermediate indole-3-pyruvic acid as an amino acceptor to produce L-tryptophan and 2-oxo-4-methylthiobutyric acid. Our data indicate that VAS1 serves key roles in coordinating the amounts of these two vital hormones.
authors: Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California, USA.
authors: Zuyu
authors: Z
authors: Zheng
authors: Yongxia
authors: Y
authors: Guo
authors: Ondřej
authors: O
authors: Novák
authors: Xinhua
authors: X
authors: Dai
authors: Yunde
authors: Y
authors: Zhao
authors: Karin
authors: K
authors: Ljung
authors: Joseph P
authors: JP
authors: Noel
authors: Joanne
authors: J
authors: Chory
mesh_terms: D000595:Amino Acid Sequence; D000598:Amino Acids, Cyclic / Q000378:metabolism; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D005030:Ethylenes / Q000096:biosynthesis*; D007210:Indoleacetic Acids / Q000378:metabolism*; D007211:Indoles; D008715:Methionine / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D011732:Pyridoxal Phosphate / Q000378:metabolism; D000637:Transaminases / Q000235:genetics / Q000378:metabolism*; D014364:Tryptophan / Q000096:biosynthesis
chemical_list: D000598:Amino Acids, Cyclic; D029681:Arabidopsis Proteins; D005030:Ethylenes; D007210:Indoleacetic Acids; D007211:Indoles; C023863:1-aminocyclopropane-1-carboxylic acid; C008122:indol-3-yl pyruvic acid; C014632:2-keto-4-methylthiobutyric acid; D011732:Pyridoxal Phosphate; D014364:Tryptophan; C036216:ethylene; D008715:Methionine; C580885:VAS1 protein, Arabidopsis; D000637:Transaminases
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