title: [The prevalance of herpesviruses in human apical periodontitis samples].
abstract: Apical periodontitis is primarily initiated by the endodonto-patogen bacteria spreading from the inflamed or necrotic pulp tissues to the periapical area. Nevertheless, findings within the past years have established a pathogenic role of human herpesviruses such as Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) in periapical inflammations. The authors analysed the prevalence, activity and disease association of EBV, HCMV and human herpesvirus 6 (HHV-6) in 40 apical periodontitis samples and 40 healthy pulp controls. Based on the viral DNA results, EBV (29/40) was the most frequent herpesvirus in apical periodontitis, followed by HHV-6 (8/40) and HCMV (4/40). According to the mRNA results approximately two-third of the EBV DNA-positive lesions had active EBV infections. However, the HHV-6 and the HCMV infections seemed to be of latent state. Our findings suggest that EBV and HHV-GB infections primarily occurred in large sized and symptomatic periapical lesions. The co-occurrence of large lesion size and active EBV infection was strongly associated (OR = 8.80) with the symptomatic manifestation of apical periodontitis.
authors: Debreceni Egyetem OEC, Orvosi Mikrobiológiai Intézet, Debrecen.
authors: Katinka
authors: K
authors: Hernádi
authors: Anita
authors: A
authors: Szalmás
authors: Richard
authors: R
authors: Mogyorósi
authors: Levente
authors: L
authors: Czompa
authors: György
authors: G
authors: Veress
authors: Eszter
authors: E
authors: Csoma
authors: Ildikó
authors: I
authors: Márton
authors: József
authors: J
authors: Kónya
mesh_terms: D016022:Case-Control Studies; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis; D004279:DNA, Viral / Q000302:isolation & purification; D003790:Dental Pulp Necrosis / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D006564:Herpesviridae / Q000235:genetics / Q000302:isolation & purification*; D006566:Herpesviridae Infections / Q000175:diagnosis* / Q000453:epidemiology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D006801:Humans; D016015:Logistic Models; D010485:Periapical Periodontitis / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D012307:Risk Factors; D019349:Roseolovirus Infections / Q000175:diagnosis
chemical_list: D004279:DNA, Viral