title: [Post transplant lymphoprolipherative disorder (PTLD) in patients after kidney transplantation--clinical manifestation, treatment and prognosis].
abstract: Post transplant lymphoprolipherative disorder (PTLD) is a very severe, life threatening complication after organ transplantation. In adults after kidney transplantation the frequency of this complication is 0.3-3%; whereas in children 0.4-10%. Epstein-Barr virus infection discovered in 90% of patients, as a result of immunosuppression, plays an important role in the PTLD etiology. There is a coincidence between heavy immunosuppression, especially its cumulative doses, and the increased risk of lymphoprolipherative disorder. The clinical manifestation of PTLD may present as: mononucleosis like syndrome (fever, pharyngitis, tonsillar enlargement, lymphadenopathy), or as a rapid progressive course presenting with severe acidosis, lymphadenopathy, dysfunction of graft and other internal organs, where infiltration may mimic tumour like appearance. The present paper discusses methods and effectiveness of PTLD treatment, which aims to restore effectiveness of the immunological system, elimination of neoplastic cells and EBV.
authors: Katedra i Klinika Nefrologii UJ CM w Krakowie.
authors: Katarzyna
authors: K
authors: Pałka
authors: Ewa
authors: E
authors: Ignacak
authors: Władysław
authors: W
authors: Sułowicz
mesh_terms: D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D011379:Prognosis