title: In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells.
abstract: Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs on the morphology, mortality, viability, membrane integrity, and type of cell death of U87 and U118 glioma cells. It was found that graphene is toxic to glioma cells, but it activated apoptosis only in the U118 cell line, without inducing necrosis, indicating the potential applicability of GP in anticancer therapy.
authors: Division of Biotechnology and Biochemistry of Nutrition, Warsaw University of Life Sciences, Warsaw, Poland.
authors: Sławomir
authors: S
authors: Jaworski
authors: Ewa
authors: E
authors: Sawosz
authors: Marta
authors: M
authors: Grodzik
authors: Anna
authors: A
authors: Winnicka
authors: Marta
authors: M
authors: Prasek
authors: Mateusz
authors: M
authors: Wierzbicki
authors: André
authors: A
authors: Chwalibog
mesh_terms: D000704:Analysis of Variance; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology*; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry
chemical_list: D006108:Graphite
keywords: apoptosis; glioma; toxicity
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