title: Impact of dietary dairy polar lipids on lipid metabolism of mice fed a high-fat diet.
abstract: The effect of milk polar lipids on lipid metabolism of liver, adipose tissue, and brain and on composition of intestinal microbiota was investigated. C57BL/6J mice were fed a high-fat diet (HFD) for 5 weeks, followed by 5 weeks with HFD without (control) or supplemented with total polar lipids (TPL), phospholipids (PL), or sphingolipids (SPL). Animals fed SPL showed a tendency for lower triglyceride synthesis (P = 0.058) in the liver, but not in adipose tissue. PL and TPL reduced de novo hepatic fatty acid biosynthesis. The ratio of palmitoleic to palmitic acid in the liver was lower for animals fed SPL or TPL compared to control. There was little effect of the supplementation on the cecal microbiota composition. In the brain, DHA (C22:6) content correlated negatively with tetracosanoic acid (C24:0) after TPL supplementation (-0.71, P = 0.02) but not in control (0.26, P = 0.44). Arachidonic acid (C20:4) was negatively correlated with C24:0 in both groups (TPL, -0.77, P = 0.008; control, -0.81, P = 0.003).
authors: Dairy Foods Team, Food and Bio-based Products, Ruakura Research Centre, AgResearch Ltd. , 3240 Hamilton, New Zealand.
authors: Mariza G
authors: MG
authors: Reis
authors: Nicole C
authors: NC
authors: Roy
authors: Emma N
authors: EN
authors: Bermingham
authors: Leigh
authors: L
authors: Ryan
authors: Rodrigo
authors: R
authors: Bibiloni
authors: Wayne
authors: W
authors: Young
authors: Lutz
authors: L
authors: Krause
authors: Bernard
authors: B
authors: Berger
authors: Mike
authors: M
authors: North
authors: Kerst
authors: K
authors: Stelwagen
authors: Marlon M
authors: MM
authors: Reis
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D003611:Dairy Products / Q000032:analysis*; D059305:Diet, High-Fat; D004063:Digestion; D005260:Female; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D008055:Lipids