title: Focal hemosiderin deposits and β-amyloid load in the ADNI cohort.
abstract: BACKGROUND
  Prevalence and risk factors for focal hemosiderin deposits are important considerations when planning amyloid-modifying trials for treatment and prevention of Alzheimer's disease (AD).
  
  
  METHODS
  Subjects were cognitively normal (n = 171), early-mild cognitive impairment (MCI) (n = 240), late-MCI (n = 111), and AD (n = 40) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Microhemorrhages and superficial siderosis were assessed at baseline and on all available MRIs at 3, 6, and 12 months. β-amyloid load was assessed with (18)F-florbetapir positron emission tomography.
  
  
  RESULTS
  Prevalence of superficial siderosis was 1% and prevalence of microhemorrhages was 25% increasing with age (P < .001) and β-amyloid load (P < .001). Topographic densities of microhemorrhages were highest in the occipital lobes and lowest in the deep/infratentorial regions. A greater number of microhemorrhages at baseline was associated with a greater annualized rate of additional microhemorrhages by last follow-up (rank correlation = 0.49; P < .001).
  
  
  CONCLUSIONS
  Focal hemosiderin deposits are relatively common in the ADNI cohort and are associated with β-amyloid load.
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: kantarci.kejal@mayo.edu.
authors: Kejal
authors: K
authors: Kantarci
authors: Jeffrey L
authors: JL
authors: Gunter
authors: Nirubol
authors: N
authors: Tosakulwong
authors: Stephen D
authors: SD
authors: Weigand
authors: Matthew S
authors: MS
authors: Senjem
authors: Ronald C
authors: RC
authors: Petersen
authors: Paul S
authors: PS
authors: Aisen
authors: William J
authors: WJ
authors: Jagust
authors: Michael W
authors: MW
authors: Weiner
authors: Clifford R
authors: CR
authors: Jack
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000704:Analysis of Variance; D000814:Aniline Compounds; D053327:Apolipoprotein E4 / Q000235:genetics; D003072:Cognition Disorders / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics; D015331:Cohort Studies; D018450:Disease Progression; D005026:Ethylene Glycols; D005260:Female; D006486:Hemosiderosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D049268:Positron-Emission Tomography; D013997:Time Factors
chemical_list: D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D053327:Apolipoprotein E4; D005026:Ethylene Glycols; C545186:florbetapir
keywords: ADNI; Alzheimer's disease; Amyloid; Early mild cognitive impairment; Florbetapir; MRI; Microhemorrhage; Mild cognitive impairment; PET; Superficial siderosis
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