title: [Knowledge creation about adverse drug reactions in the paediatric population].
abstract: Knowledge of adverse drug reactions (ADRs) from medicine use in children is limited. We analyzed 4,500 ADRs submitted for children from ages 0 to 17 years to the Danish National ADR Database in the period from 1998 to 2007 with respect to occurrence, seriousness and type of reported ADRs, therapeutic group, age, gender and reporter. 40 per cent of the reported ADRs were serious, and fatal cases were found. Half of the ADRs were reported in children from 0 up to 2 years of age. The majority of the ADRs were reported for immunization therapies, antibiotics and psychotropic medicine. Physicians reported 90% of all ADRs.
authors: Forskningsenheden for Klinisk Farmakologi, Institut for Sundhedstjenesteforskning, Det Sundhedsvidenskabelige Fakultet, Syddansk Universitet, J.B. Winsløws Vej 19, 5000 Odense C, Denmark. laagaard@health.sdu.dk
authors: Lise
authors: L
authors: Aagaard
mesh_terms: D000293:Adolescent; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D002648:Child; D046688:Child Mortality; D002675:Child, Preschool; D016208:Databases, Factual; D003718:Denmark / Q000453:epidemiology; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D056687:Off-Label Use; D010372:Pediatrics / Q000193:education*; D060735:Pharmacovigilance