title: Effects of peritoneal-and hemodialysis on levels of plasma protein and lipid oxidation markers in diabetic patients.
abstract: OBJECTIVE
  The aim of this paper was to evaluate the effects of dialysis procedures on oxidative stress in diabetic patients.
  
  
  METHODS
  The study was performed on 15 non-diabetic hemodialysis (HD) patients, 30 non-diabetic perinoteal dialysis (PD) patients, 18 diabetic HD patients (DHD), 15 diabetic PD patients (DPD), and 20 healthy controls. Plasma thiobarbituric acid reactive substances (TBARS), protein carbonyl (PCO), and oxidized LDL (oxLDL) were determined as oxidative stress markers. Plasma thiol (P-SH), erythrocyte glutathione (GSH) levels, and serum paraoxonase (PON1) activities were measured as antioxidants.
  
  
  RESULTS
  HD patients have significantly higher oxLDL, TBARS and PCO levels and significantly lower P-SH levels than PD patients. DHD patients have significantly higher PCO levels and PON1 activities and significantly lower GSH levels than non-diabetic HD patients. There was no any difference in oxidative stress parameters between DPD and non-diabetic PD patients.
  
  
  CONCLUSIONS
  Oxidative stress is exacerbated by HD in diabetic patients. Treatment strategy with antioxidants in dialysis patients may be associated with a worsened survival.
authors: Department of Biochemistry, Yildiz Technical University, Istanbul, Turkey.
authors: V
authors: V
authors: Sozer
authors: G
authors: G
authors: Korkmaz Guntas
authors: D
authors: D
authors: Konukoglu
authors: E
authors: E
authors: Dervisoglu
authors: R
authors: R
authors: Gelisgen
authors: O
authors: O
authors: Tabak
authors: B
authors: B
authors: Kalender
authors: H
authors: H
authors: Uzun
mesh_terms: D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism* / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010530:Peritoneal Dialysis; D050050:Protein Carbonylation; D006435:Renal Dialysis; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; D017392:Thiobarbituric Acid Reactive Substances; C099252:oxidized low density lipoprotein; D043303:Aryldialkylphosphatase; D005978:Glutathione