title: Adverse events after endovascular treatment of chronic cerebro-spinal venous insufficiency (CCSVI) in patients with multiple sclerosis.
abstract: Although it is debated whether chronic cerebro-spinal venous insufficiency (CCSVI) plays a role in multiple sclerosis (MS) development, many patients undergo endovascular treatment (ET) of CCSVI. A study is ongoing in Italy to evaluate the clinical outcome of ET. Severe adverse events (AEs) occurred in 15/462 subjects at a variable interval after ET: jugular thrombosis in seven patients, tetraventricular hydrocephalus, stroke, paroxysmal atrial fibrillation, status epilepticus, aspiration pneumonia, hypertension with tachicardia, or bleeding of bedsore in the remaining seven cases. One patient died because of myocardial infarction 10 weeks after ET. The risk of severe AEs related to ET for CCSVI must be carefully considered.
authors: Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Italy. angelo.ghezzi@aogallarate.it
authors: A
authors: A
authors: Ghezzi
authors: P
authors: P
authors: Annovazzi
authors: M P
authors: MP
authors: Amato
authors: E
authors: E
authors: Capello
authors: P
authors: P
authors: Cavalla
authors: E
authors: E
authors: Cocco
authors: M
authors: M
authors: Falcini
authors: A
authors: A
authors: Gallo
authors: F
authors: F
authors: Patti
authors: P
authors: P
authors: Perini
authors: M E
authors: ME
authors: Rodegher
authors: M
authors: M
authors: Rovaris
authors: M R
authors: MR
authors: Rottoli
authors: G
authors: G
authors: Comi
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply; D057510:Endovascular Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000209:etiology / Q000628:therapy*; D013116:Spinal Cord / Q000098:blood supply; D014689:Venous Insufficiency / Q000150:complications / Q000628:therapy*
keywords: CCSVI; endovascular treatment; multiple sclerosis