title: Visceral blood flow modulation: potential therapy for morbid obesity.
abstract: We present this preliminary investigation into the safety and feasibility of endovascular therapy for morbid obesity in a swine model. A flow-limiting, balloon-expandable covered stent was placed in the superior mesenteric artery of three Yorkshire swine after femoral arterial cutdown. The pigs were monitored for between 15 and 51 days after the procedure and then killed, with weights obtained at 2-week increments. In the two pigs in which the stent was flow limiting, a reduced rate of weight gain (0.42 and 0.53 kg/day) was observed relative to the third pig (0.69 kg/day), associated with temporary food aversion and signs of mesenteric ischemia in one pig.
authors: Department of Vascular and Interventional Radiology, University of California, Los Angeles, 757 Westwood Blvd., Suite 1638, Los Angeles, CA 90095-7437, USA. tjharris@gmail.com
authors: Tyler J
authors: TJ
authors: Harris
authors: Timothy P
authors: TP
authors: Murphy
authors: Bryan S
authors: BS
authors: Jay
authors: Christopher O
authors: CO
authors: Hampson
authors: Abdul M
authors: AM
authors: Zafar
mesh_terms: D000792:Angiography; D000818:Animals; D004195:Disease Models, Animal; D005240:Feasibility Studies; D017538:Mesenteric Artery, Superior / Q000000981:diagnostic imaging / Q000502:physiology*; D009767:Obesity, Morbid / Q000628:therapy*; D015641:Radiography, Interventional; D015607:Stents; D013552:Swine; D014781:Viscera / Q000098:blood supply*