title: Reduced serum progranulin level might be associated with Parkinson's disease risk.
abstract: OBJECTIVE
  Common genetic variants (rs5848 and rs646776) have been reported as regulators of blood progranulin (GRN) levels in healthy individuals.
  
  
  METHODS
  To assess the influence of rs5848 and rs646776 polymorphisms in both serum GRN level and risk for common neurodegenerative diseases, we studied 304 patients with Parkinson's disease (PD), 217 individuals with Alzheimer's disease, 131 subjects with mild cognitive impairment, and 126 controls.
  
  
  RESULTS
  The mean concentration of GRN in the serum of patients with PD (319.6 ng/ml) was significantly lower than that of controls (371.5 ng/ml; P = 0.009), whereas there were no significant differences between other groups. Rs646776 minor allele carriers had lower serum GRN levels in each of the four subgroups. There was no correlation between rs5848 genotypes and serum GRN concentrations. Genotype frequencies of both polymorphisms did not differ between groups.
  
  
  CONCLUSIONS
  Reduced circulating GRN levels might be associated with PD risk by pathogenic factors different from rs5848 and rs646776 polymorphisms.
authors: Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital, Santander, Spain.
authors: I
authors: I
authors: Mateo
authors: I
authors: I
authors: González-Aramburu
authors: A
authors: A
authors: Pozueta
authors: J L
authors: JL
authors: Vázquez-Higuera
authors: E
authors: E
authors: Rodríguez-Rodríguez
authors: P
authors: P
authors: Sánchez-Juan
authors: M
authors: M
authors: Calero
authors: J L
authors: JL
authors: Dobato
authors: J
authors: J
authors: Infante
authors: J
authors: J
authors: Berciano
authors: O
authors: O
authors: Combarros
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000235:genetics; D008297:Male; D010300:Parkinson Disease / Q000097:blood* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D000077153:Progranulins
chemical_list: C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins
keywords: Alzheimer's disease; Parkinson's disease; polymorphism; progranulin; risk factor; serum