title: Coronary stents cause high velocity fluctuation with a flow acceleration and flow reduction in jailed branches: an in vitro study using laser-Doppler anemometry.
abstract: Flow disturbance and reduced blood flow have been associated with higher restenosis rates and clinical adverse events after coronary interventions. In the present study, we sought to investigate flow alterations that occurred after stent implantation in a coronary model, within and adjacent to the stented segment. Two stents (Carbostent, Tetrastent) with different strut design were deployed in the left anterior descending artery (LAD) of a 1:1 scaled silicon coronary model. The model was mounted into an artificial circulation and showed distensibility and rheologic behavior comparable to human coronaries. Flow profiles were assessed using laser-Doppler anemometry. Both stents induced a transitional flow within the stents, in the jailed branch as well as in the adjacent segments. However, the alterations in flow were less marked using the Carbostent having stents with thinner struts and a larger strut cell area, and thus seem to be more favorable in avoiding bifurcation lesions. This study shows precisely that stent implantation induces flow disturbances in segments known to be prone for restenosis. Investigations using laser-Doppler measurements may enlighten rheologic phenomena inducing restenosis and help in optimizing stent design and deployment techniques.
authors: 3rd Department of Medicine, Cardiology, Innsbruck Medical University, Innsbruck, Austria.
authors: Jakob
authors: J
authors: Dörler
authors: Matthias
authors: M
authors: Frick
authors: Monika
authors: M
authors: Hilber
authors: Harald
authors: H
authors: Breitfuss
authors: Mohammed N
authors: MN
authors: Abdel-Hadi
authors: Otmar
authors: O
authors: Pachinger
authors: Dieter
authors: D
authors: Liepsch
authors: Severin P
authors: SP
authors: Schwarzacher
mesh_terms: D001802:Blood Substitutes; D003331:Coronary Vessels / Q000502:physiology; D017078:Laser-Doppler Flowmetry; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D015607:Stents
chemical_list: D001802:Blood Substitutes