title: Hypofractionated radiotherapy with tomotherapy for patients with hepatic oligometastases: retrospective analysis of two institutions.
abstract: To evaluate the efficacy and toxicity for patients with hepatic oligometastases, receiving hypofractionated radiotherapy with Tomotherapy to the liver. A total of 42 patients with 54 hepatic lesions, who had been treated from 2007 to 2011 at two institutions, were retrospectively reviewed for this study. All the patients received radical resections of the primary tumor, and had been presented with one to two hepatic lesions. The radiation dose of 40-75 Gy in 10-20 fractions (median, 50 Gy in 10 fractions) was delivered for the planning target volume. At a median follow-up time of 15 months, 1- and 2-year local control (LC) rates were 59.9 and 49.0 %, respectively. The 1- and 2-year overall survival (OS) rates were 60.0 and 44.0 %, respectively. Maximal tumor diameter of <3 cm and biologically effective dose (BED) of ≥100 Gyα/β=10 were significantly associated with higher LC and OS. Primary colorectal cancer tended to be associated with higher LC (P = 0.075), and was significantly associated with higher OS (P = 0.037). 12 (28.6 %) of the 42 patients had grade 1-2 toxicities, and grade 3 or higher toxicity did not occur. Hypofractionated radiotherapy with Tomotherapy was safe for patients with hepatic oligometastases. The maximal tumor diameter of <3 cm and BED of ≥100 Gyα/β=10 were significant prognostic factors for higher local control and survival, and primary colorectal cancer patients had statistically higher overall survival than the others.
authors: Department of Radiation Oncology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93-6, Ji-dong, Paldal-gu, Suwon, Gyeonggi-do, 442-723, Republic of Korea.
authors: Jong Hoon
authors: JH
authors: Lee
authors: Joo Hwan
authors: JH
authors: Lee
authors: Hong Seok
authors: HS
authors: Jang
authors: Hyo Chun
authors: HC
authors: Lee
authors: Jung Won
authors: JW
authors: Lee
authors: Dae Gyu
authors: DG
authors: Kang
authors: Byoung Yong
authors: BY
authors: Shim
authors: Bong-Hyeon
authors: BH
authors: Kye
authors: Hyung Jin
authors: HJ
authors: Kim
authors: Hyeon-Min
authors: HM
authors: Cho
authors: Young Jin
authors: YJ
authors: Suh
authors: Sung Hwan
authors: SH
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D016896:Treatment Outcome
references: J Support Oncol. 2008 Jan;6(1):9-13, 15
references: 18257395
references: Cancer Res Treat. 2012 Mar;44(1):11-24
references: 22500156
references: Gynecol Oncol. 2003 Oct;91(1):39-45
references: 14529660
references: J Clin Oncol. 1995 Jan;13(1):8-10
references: 7799047
references: Ann Surg Oncol. 2012 Apr;19(4):1213-21
references: 21935746
references: Eur Radiol. 2005 May;15(5):884-94
references: 15754165
references: J Clin Oncol. 2009 Apr 1;27(10):1572-8
references: 19255321
references: Clin Exp Metastasis. 2010 Apr;27(4):273-8
references: 20373133
references: J Gastrointest Surg. 2007 Apr;11(4):472-8
references: 17436132
references: Clin Exp Metastasis. 2012 Aug;29(6):541-9
references: 22476470
references: Acta Oncol. 2006;45(7):838-47
references: 16982548
references: Jpn J Clin Oncol. 2010 Feb;40(2):107-11
references: 20047860
references: Arch Surg. 2006 May;141(5):460-6; discussion 466-7
references: 16702517
references: Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):955-61
references: 22537540
references: Lung Cancer. 2008 Oct;62(1):55-61
references: 18394750
references: Cancer. 2004 Oct 1;101(7):1623-31
references: 15378503
references: Cancer. 1996 Apr 1;77(7):1254-62
references: 8608500
references: Cancer. 2000 Jul 15;89(2):276-84
references: 10918156
references: Surgery. 1991 Jul;110(1):13-29
references: 1866690
references: Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):112-8
references: 18786780
references: Int J Radiat Oncol Biol Phys. 2011 Oct 1;81(2):431-8
references: 20732756
references: J Clin Oncol. 2006 Jul 20;24(21):3333-9
references: 16849747