title: Sleep disturbances in psoriasis.
abstract: BACKGROUND
  Psoriasis negatively impacts sleep, but the factors that cause this sleep disturbance are not well characterized.
  
  
  OBJECTIVE
  To assess sleep quality in subjects with psoriasis.
  
  
  METHODS
  35 outpatients diagnosed with chronic plaque psoriasis affecting at least 10 percent BSA and 44 controls completed the Pittsburgh Sleep Quality Index, Patient Health Questionnaire, Itch Severity Scale, Insomnia Severity Index, and Epworth Sleepiness Scale. For multiple testing, alpha was set at 0.008.
  
  
  RESULTS
  Adjusting for age, BMI, and gender, patients with psoriasis had 4.3 times the odds to score in a higher insomnia category (OR 95% CI: 1.7, 11.2; p=0.01), a trend toward experiencing "poor sleep" (p=0.04), and no difference in odds to be "sleepy" (p=0.83). Patients with psoriasis had greater itch than those without psoriasis (mean ISS 8.5 vs. 2.0; p<0.0001). When adjusting for age, BMI, gender, and depression, those with psoriasis were not more likely to experience poor sleep quality (p=0.25), nor to score in a higher insomnia category (p=0.20) or be more "sleepy" (p=0.53).
  
  
  CONCLUSIONS
  Patients with psoriasis suffer from sleep disturbances and pruritus more than those without psoriasis. Although sleep disturbances are more prevalent, this may be secondary to depression rather than related to a direct effect of psoriasis.
authors: Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston Salem, NC, USA.
authors: Brandon G
authors: BG
authors: Shutty
authors: Cameron
authors: C
authors: West
authors: Karen E
authors: KE
authors: Huang
authors: Erin
authors: E
authors: Landis
authors: Tushar
authors: T
authors: Dabade
authors: Betsy
authors: B
authors: Browder
authors: Jenna
authors: J
authors: O'Neill
authors: Megan A
authors: MA
authors: Kinney
authors: Ashley N
authors: AN
authors: Feneran
authors: Sarah
authors: S
authors: Taylor
authors: Brad
authors: B
authors: Yentzer
authors: W Vaughn
authors: WV
authors: McCall
authors: Alan B
authors: AB
authors: Fleischer
authors: Steven R
authors: SR
authors: Feldman
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003863:Depression / Q000150:complications*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000150:complications*; D011565:Psoriasis / Q000150:complications*; D011788:Quality of Life; D012720:Severity of Illness Index; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000209:etiology*; D011795:Surveys and Questionnaires