title: Charity begins at home: non-coding RNA functions in DNA repair.
abstract: During the past decade, evolutionarily conserved microRNAs (miRNAs) have been characterized as regulators of almost every cellular process and signalling pathway. There is now emerging evidence that this new class of regulators also impinges on the DNA damage response (DDR). Both miRNAs and other small non-coding RNAs (ncRNAs) are induced at DNA breaks and mediate the repair process. These intriguing observations raise the possibility that crosstalk between ncRNAs and the DDR might provide a means of efficient and accurate DNA repair and facilitate the maintenance of genomic stability.
authors: Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA. dipanjan_chowdhury@dfci.harvard.edu
authors: Dipanjan
authors: D
authors: Chowdhury
authors: Young Eun
authors: YE
authors: Choi
authors: Marie Eve
authors: ME
authors: Brault
mesh_terms: D002453:Cell Cycle / Q000235:genetics; D002468:Cell Physiological Phenomena; D053960:DNA Breaks; D004260:DNA Repair; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated
references: J Biol Chem. 2012 Jun 22;287(26):21783-95
references: 22547075
references: Nat Rev Cancer. 2012 Sep;12(9):613-26
references: 22898542
references: Semin Oncol. 2011 Dec;38(6):743-51
references: 22082760
references: Nature. 2011 Mar 24;471(7339):532-6
references: 21399625
references: J Biochem. 2010 Oct;148(4):381-92
references: 20833630
references: Curr Biol. 2008 Jun 24;18(12):861-7
references: 18501605
references: Mol Cell. 2012 Jul 27;47(2):320-9
references: 22841003
references: Genes Dev. 2006 Jul 1;20(13):1732-43
references: 16766679
references: Dev Cell. 2005 Mar;8(3):321-30
references: 15737928
references: Nat Rev Genet. 2010 Aug;11(8):559-71
references: 20628352
references: Nature. 2007 May 17;447(7142):338-41
references: 17429354
references: J Biol Chem. 2002 Apr 12;277(15):12710-7
references: 11821415
references: Proc Natl Acad Sci U S A. 1996 May 14;93(10):4827-32
references: 8643488
references: Nat Rev Genet. 2012 Mar 13;13(4):271-82
references: 22411466
references: Mol Cell. 2011 Jan 21;41(2):210-20
references: 21195000
references: Annu Rev Biochem. 2010;79:181-211
references: 20192759
references: Cell Res. 2008 Jan;18(1):134-47
references: 18157161
references: Science. 2007 May 4;316(5825):744-7
references: 17446352
references: Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11667-72
references: 19571010
references: Nat Struct Mol Biol. 2012 Feb 12;19(3):276-82
references: 22343725
references: Annu Rev Biochem. 2008;77:229-57
references: 18275380
references: Cell. 2010 Jun 11;141(6):970-81
references: 20550933
references: Genome Res. 2009 Jan;19(1):92-105
references: 18955434
references: EMBO J. 2011 Mar 16;30(6):1079-92
references: 21317870
references: Mol Cell Biol. 2003 Apr;23(7):2556-63
references: 12640136
references: Oncogene. 2008 Jan 10;27(3):318-22
references: 17637749
references: Cell. 2012 Mar 30;149(1):101-12
references: 22445173
references: Hum Genet. 2011 Aug;130(2):247-53
references: 21660507
references: Nat Rev Genet. 2007 Jun;8(6):413-23
references: 17486121
references: Cell. 2002 Nov 1;111(3):393-405
references: 12419249
references: Mol Cell. 2009 Aug 28;35(4):403-13
references: 19716786
references: Oncogene. 2010 Dec 2;29(48):6390-401
references: 20802525
references: EMBO Mol Med. 2011 May;3(5):279-90
references: 21472990
references: Nat Struct Mol Biol. 2012 Jun 05;19(6):586-93
references: 22664986
references: Cancer Cell. 2007 Sep;12(3):215-29
references: 17785203
references: Nat Cell Biol. 2007 Aug;9(8):978-81
references: 17643113
references: Nat Med. 2011 Sep 25;17(10):1275-82
references: 21946536
references: Cancer Res. 2012 Aug 15;72(16):4037-46
references: 22761336
references: PLoS One. 2010 Jul 01;5(7):e11397
references: 20617180
references: Mol Cell. 2012 Aug 24;47(4):497-510
references: 22920291
references: Mol Cancer Res. 2011 Aug;9(8):1100-11
references: 21693595
references: Trends Biochem Sci. 2011 Sep;36(9):478-84
references: 21741842
references: J Cell Biol. 2012 Apr 16;197(2):201-8
references: 22492723
references: Nat Rev Genet. 2011 Nov 18;12(12):861-74
references: 22094949
references: Heredity (Edinb). 2012 Jan;108(1):42-9
references: 22072070
references: Semin Cell Dev Biol. 2010 Apr;21(2):186-93
references: 19815087
references: Nature. 2009 May 14;459(7244):274-7
references: 19444217
references: Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1506-11
references: 20080624
references: Nat Rev Genet. 2009 Feb;10(2):94-108
references: 19148191
references: Nature. 2009 May 21;459(7245):460-3
references: 19357644
references: Nature. 2009 Jun 18;459(7249):1010-4
references: 19458619
references: Nat Rev Cancer. 2007 Nov;7(11):819-22
references: 17914404
references: Dev Cell. 2004 Nov;7(5):653-62
references: 15525527
references: EMBO J. 2009 Jul 22;28(14):2090-9
references: 19536137
references: Biochemistry. 1998 Feb 3;37(5):1336-43
references: 9477961
references: Nucleic Acids Res. 2012 Oct;40(19):9596-603
references: 22848104
references: Nat Cell Biol. 2012 Feb 19;14(3):318-28
references: 22344029
references: Mol Cell Biol. 2005 Nov;25(22):10079-86
references: 16260621
references: Curr Opin Cell Biol. 2011 Jun;23(3):258-65
references: 21478005
references: Cell. 2009 Oct 2;139(1):112-22
references: 19804757
references: Mol Cell. 2011 Feb 18;41(4):371-83
references: 21329876
references: Annu Rev Biochem. 2012;81:145-66
references: 22663078
references: Nature. 2011 Jan 13;469(7329):245-9
references: 21160476
references: J Cell Biochem. 2008 Oct 15;105(3):824-34
references: 18729083
references: Annu Rev Biochem. 2010;79:351-79
references: 20533884
references: Nat Rev Mol Cell Biol. 2011 Apr;12(4):246-58
references: 21427766
references: Prostate. 2008 Nov 1;68(15):1599-606
references: 18668526
references: J Mol Cell Biol. 2012 Apr;4(2):108-17
references: 22158906
references: Science. 2004 Jan 30;303(5658):672-6
references: 14704433
references: EMBO J. 2004 Aug 4;23(15):3164-74
references: 15282542
references: Nat Rev Genet. 2011 Feb;12(2):99-110
references: 21245828
references: Cell. 2009 Jan 23;136(2):215-33
references: 19167326
references: Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5613-7
references: 8516308
references: J Mol Cell Biol. 2011 Jun;3(3):151-8
references: 21183529
references: Mol Cell Biol. 2007 Apr;27(7):2562-71
references: 17242200
references: Mol Cell. 2007 Oct 12;28(1):134-46
references: 17936710
references: Int J Radiat Oncol Biol Phys. 2011 Jun 1;80(2):549-57
references: 21420249
references: Nature. 2008 Jul 3;454(7200):126-30
references: 18509338
references: Mol Cell. 2010 Oct 22;40(2):179-204
references: 20965415
references: Science. 2007 Nov 2;318(5851):798-801
references: 17916692
references: Nature. 2009 Mar 12;458(7235):223-7
references: 19182780
references: Nature. 2008 Jan 10;451(7175):153-8
references: 18046331
references: Mol Cell. 2012 Feb 24;45(4):505-16
references: 22365830
references: Nature. 2012 Aug 9;488(7410):231-5
references: 22722852
references: Nat Struct Mol Biol. 2010 Jun;17(6):688-95
references: 20453858
references: J Cell Sci. 2005 May 1;118(Pt 9):2043-55
references: 15840649
references: J Pathol. 2012 Oct;228(2):204-15
references: 22322863
references: J Biol Chem. 2006 Dec 29;281(52):40503-14
references: 17098743
references: J Cell Sci. 2012 Aug 1;125(Pt 15):3529-34
references: 22553214
references: Nucleic Acids Res. 2012 Apr;40(8):3689-703
references: 22210864
references: Nat Struct Mol Biol. 2009 May;16(5):492-8
references: 19377482
references: J Cell Sci. 2010 Jun 1;123(Pt 11):1825-39
references: 20484663
references: PLoS One. 2011;6(9):e25454
references: 21980462
references: Breast Cancer Res. 2003;5(1):45-52
references: 12559046
references: Cell. 2010 Apr 16;141(2):243-54
references: 20362325
references: Nat Rev Genet. 2011 Jan;12(1):19-31
references: 21116305