title: [2nd place in the competition of scientific papers in hepatology 2012].
abstract: OBJECTIVE
  To evaluate the effect of acute administration of dophamine on systemic hemodynamic, renal function and control ascities in patients with cirrhosis.
  
  
  METHODS
  51 patients with cirrhosis with normal serum Cr (mean age 54 +/- 3,0, males 90,3%, females 9,7%) were studied. All patients were measured of urine volume, sodium excretion, glomerular filtration rate (GFR), 24h blood pressure monitoring (BP) before and after dophamine intfavenous introduction (2-3 mkg/kg/min during 4 hours). Using receiver operating characteristic curve analysis, a increase of GFR < 5% was the best value to predict refractor ascities (increase GFR > or = 10-15% is normal, GFR <6-9% - is initial sing of interglomerule's hypertension).
  
  
  RESULTS
  25 patients (48,5%) had a significant increase a urine volume (p = 0,03), sodium excretion (p = 0,04), GFR (by > or = 10%, p = 0,035), mean artery pressure (p = 0,01) after dophamine introduction. This group had a lower risk of developing refractor ascites (p = 0,001). 20 (30,9%) patients (9 patients - class B Child-Pugh, 8 patients - class C Child-Pugh) had demonstrated a authentic increase a urine volume and mean artery pressure, but low increase GFR (by < 6-9%, p = 0,05). GFR < 5% was in 6 (11,6%) patients (2 pts - class B Child-Pugh, 4 pts - class C Child-Pugh) and urine volume did not change, that means high risk of development of a refractory ascites in the given group.
  
  
  CONCLUSIONS
  The acute hemodynamic response to dophamine can be used to predict current of ascites and the risk of refractory ascites.
authors: L V
authors: LV
authors: Fedulenkova
mesh_terms: D001201:Ascites / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology* / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology* / Q000652:urine; D008297:Male; D008875:Middle Aged; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014662:Vasoconstrictor Agents