title: Dual-channel electrospray microchip.
abstract: A dual-channel electrospray microchip has been developed for electrospray ionization mass spectrometry (ESI-MS) where aqueous samples are mixed at the Taylor cone with an organic buffer. Due to the fast and effective mixing in the Taylor cone, the aqueous sample can be well ionized with a high ion intensity. The influence of geometric parameters such as the distance between the two microchannels at their junction at the tip of the emitter has been investigated together with chemical parameters such as the organic buffer composition.
authors: Laboratoire d'Electrochimie Physique et Analytique, Station 6, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
authors: Yu
authors: Y
authors: Lu
authors: Fang
authors: F
authors: Liu
authors: Niels
authors: N
authors: Lion
authors: Hubert H
authors: HH
authors: Girault
mesh_terms: D002021:Buffers; D004867:Equipment Design; D046228:Microarray Analysis / Q000295:instrumentation*; D010455:Peptides / Q000737:chemistry; D012996:Solutions; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation*; D014867:Water / Q000737:chemistry
chemical_list: D002021:Buffers; D010455:Peptides; D012996:Solutions; D014867:Water
references: Anal Chem. 2009 Sep 1;81(17):7281-7
references: 19715359
references: Anal Sci. 2008;24(11):1399-404
references: 18997365
references: Proteomics. 2002 Apr;2(4):405-12
references: 12164699
references: Mass Spectrom Rev. 2001 Nov-Dec;20(6):362-87
references: 11997944
references: Anal Chem. 1996 Jan 1;68(1):1-8
references: 8779426
references: Mass Spectrom Rev. 2009 Nov-Dec;28(6):918-36
references: 19479726
references: Analyst. 2009 Nov;134(11):2189-203
references: 19838404
references: Anal Chem. 2012 Jun 5;84(11):4647-51
references: 22571167
references: Anal Chem. 2008 Apr 1;80(7):2531-8
references: 18318548
references: J Am Soc Mass Spectrom. 1994 Jul;5(7):605-13
references: 24221962
references: Anal Chem. 2008 Dec 15;80(24):9499-507
references: 19072264
references: J Chromatogr A. 2003 Jun 27;1003(1-2):11-9
references: 12899293