title: Bronchiectasis in older patients with chronic obstructive pulmonary disease : prevalence, diagnosis and therapeutic management.
abstract: The prevalence of chronic obstructive pulmonary disease (COPD) increases with age. Recent evidence suggests that the finding of co-existent bronchiectasis is becoming increasingly common, possibly because of increased use of high-resolution CT scanning in the assessment of patients with COPD. This may represent a distinct phenotype of COPD, but, nevertheless, it is likely to pose an increased burden to health services and challenges in determining the correct management of these patients. Here, we review the factors associated with bronchiectasis in older patients with COPD and the evidence for many of the therapies currently used in the treatment of patients, providing a rational approach to their management.
authors: Department of Lung Function and Sleep, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK.
authors: Deborah
authors: D
authors: Whitters
authors: Robert A
authors: RA
authors: Stockley
mesh_terms: D000368:Aged; D000818:Animals; D001987:Bronchiectasis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy
references: Respir Med. 1997 Aug;91(7):395-8
references: 9327038
references: N Engl J Med. 2008 Oct 9;359(15):1543-54
references: 18836213
references: Nihon Kyobu Shikkan Gakkai Zasshi. 1987 Jun;25(6):632-42
references: 3682440
references: Drugs. 2007;67(7):965-74
references: 17488142
references: Proc Am Thorac Soc. 2007 Dec;4(8):602-5
references: 18073390
references: Chest. 2011 Nov;140(5):1107-1108
references: 22045871
references: Am Rev Respir Dis. 1993 Feb;147(2):301-6
references: 8430952
references: Respir Res. 2011 Jan 27;12:18
references: 21272339
references: Cochrane Database Syst Rev. 2009 Jan 21;(1):CD000996
references: 19160186
references: Am J Respir Cell Mol Biol. 2001 Oct;25(4):492-9
references: 11694455
references: Am J Respir Crit Care Med. 2008 Apr 15;177(8):853-60
references: 18202344
references: Thorax. 2008 May;63(5):415-22
references: 18234905
references: Chest. 2002 May;121(5 Suppl):121S-126S
references: 12010839
references: Ann Pharmacother. 2004 Sep;38(9):1400-5
references: 15252191
references: Thorax. 2006 Mar;61(3):250-8
references: 16517585
references: Chest. 2011 Nov;140(5):1130-1137
references: 21546440
references: Respir Med. 2006 Sep;100(9):1623-32
references: 16434174
references: Thorax. 2000 Mar;55(3):198-204
references: 10679538
references: Thorax. 2000 Aug;55(8):635-42
references: 10899238
references: Int J Chron Obstruct Pulmon Dis. 2011;6:147-55
references: 21468165
references: Am J Respir Crit Care Med. 2008 Jan 1;177(1):19-26
references: 17916806
references: Chest. 2008 Mar;133(3):767-74
references: 17890468
references: Eur Respir J. 2007 Dec;30(6):1124-30
references: 17715170
references: J Immunol. 2004 Jul 1;173(1):673-81
references: 15210831
references: J Allergy. 1970 Mar;45(3):146-62
references: 5309312
references: COPD. 2005 Mar;2(1):27-34
references: 17136958
references: Int J Chron Obstruct Pulmon Dis. 2009;4:411-9
references: 20037680
references: Am J Respir Crit Care Med. 2003 Oct 15;168(8):976-82
references: 12816740
references: Am J Respir Crit Care Med. 1998 Sep;158(3):723-7
references: 9730996
references: Eur Respir J. 2006 Sep;28(3):523-32
references: 16611654
references: Thorax. 1996 Sep;51(9):914-8
references: 8984702
references: Vaccine. 2005 Jul 8;23 Suppl 1:S10-25
references: 15908062
references: Cochrane Database Syst Rev. 2003;(3):CD003572
references: 12917973
references: Respir Med. 2010 Jul;104(7):981-5
references: 20303725
references: Science. 1996 Nov 1;274(5288):740-3
references: 8966556
references: Am J Respir Crit Care Med. 2006 May 1;173(9):991-8
references: 16474030
references: BMJ. 2006 May 13;332(7550):1142-4
references: 16690673
references: Eur Respir J. 2008 Feb;31(2):396-406
references: 18238949
references: Chest. 1995 Aug;108(2 Suppl):53S-57S
references: 7634926
references: Chest. 2010 Oct;138(4):944-9
references: 20435655
references: Am J Respir Crit Care Med. 2004 Aug 15;170(4):400-7
references: 15130905
references: Eur Respir J. 2009 Sep;34(3):641-7
references: 19443528
references: Respir Med. 1992 Mar;86(2):121-4
references: 1615177
references: Am J Respir Crit Care Med. 2007 Dec 15;176(12):1215-21
references: 17872489
references: J Infect Dis. 1998 Aug;178(2):431-40
references: 9697723
references: Chest. 2007 Nov;132(5):1565-72
references: 17998359
references: Br J Dis Chest. 1985 Jul;79(3):301-4
references: 3874645
references: Cochrane Database Syst Rev. 2001;(4):CD002155
references: 11687145
references: Curr Opin Pulm Med. 2010 Mar;16(2):118-22
references: 19926996
references: Thorax. 2002 Sep;57(9):759-64
references: 12200518
references: Treat Respir Med. 2005;4(2):117-22
references: 15813663
references: Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1277-84
references: 11029331
references: Wkly Epidemiol Rec. 2006 Nov 24;81(47):445-52
references: 17124755
references: Heart Lung. 2006 Jan-Feb;35(1):58-65
references: 16426936
references: Chest. 2012 Feb;141(2):461-468
references: 21778259
references: Chest. 2005 Aug;128(2):739-45
references: 16100162
references: Am J Respir Crit Care Med. 2008 Dec 1;178(11):1139-47
references: 18723437
references: N Engl J Med. 2011 Aug 25;365(8):689-98
references: 21864166
references: Eur J Respir Dis Suppl. 1986;147:6-15
references: 3533593
references: Clin Infect Dis. 1999 Aug;29(2):281-8
references: 10476727
references: Thorax. 2010 Jul;65 Suppl 1:i1-58
references: 20627931
references: Eur Respir J. 2010 May;35(5):949-51
references: 20436169
references: Chest. 2000 Jun;117(6):1638-45
references: 10858396
references: Chest. 2002 Oct;122(4):1247-55
references: 12377849
references: J Infect Chemother. 2007 Dec;13(6):357-67
references: 18095083
references: Eur Respir J. 2001 May;17(5):995-1007
references: 11488337
references: Thorax. 2005 Mar;60(3):239-43
references: 15741443
references: Eur Respir J. 1999 Feb;13(2):361-4
references: 10065682
references: Am J Respir Crit Care Med. 2001 Nov 1;164(9):1628-32
references: 11719301
references: Respir Res. 2010 Sep 10;11:122
references: 20831787
references: Chest. 2004 Feb;125(2 Suppl):41S-50S; quiz 51S
references: 14872000
references: Proc Am Thorac Soc. 2008 May 1;5(4):475-7
references: 18453358
references: Cochrane Database Syst Rev. 2006 Jan 25;(1):CD002733
references: 16437444
references: Eur Respir J. 2011 Dec;38(6):1250-1
references: 22130759