title: Small cell neuroendocrine tumor of the larynx--a small case series.
abstract: Neuroendocrine tumors are the most common nonsquamous types of laryngeal neoplasms. They are classified as typical carcinoids, atypical carcinoids, small-cell neuroendocrine carcinomas, and paragangliomas. The aim of the paper is to present four patients with small-cell neuroendocrine tumor arising in larynx. There were one woman and three men whose ages were 47-77 years; all of them had metastases when first seen. The clinical presentation and management of such type of tumor are discussed. Small-cell neuroendocrine carcinomas are very aggressive neoplasms. Patients could benefit from surgery, but radiotherapy and chemotherapy remain the treatment of choice. Examination of a large series is required to define the most useful diagnostic methods and the most successful treatment modalities.
authors: Clinical Center of Serbia, Institute of Otorhinolaryngology and Maxillofacial Surgery, Belgrade, Serbia. braca5@eunet.rs
authors: Anton
authors: A
authors: Mikić
authors: Elvir
authors: E
authors: Zvrko
authors: Aleksandar
authors: A
authors: Trivić
authors: Dusan
authors: D
authors: Stefanović
authors: Mileta
authors: M
authors: Golubović
mesh_terms: D000368:Aged; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed