title: Long-term reproducibility of cirrus HD optical coherence tomography deviation map in clinically stable glaucomatous eyes.
abstract: OBJECTIVE
  To determine the long-term reproducibility of the retinal nerve fiber layer (RNFL) thickness deviation map in glaucoma patients.
  
  
  METHODS
  Retrospective, longitudinal study.
  
  
  METHODS
  One hundred two eyes of 102 glaucoma patients.
  
  
  METHODS
  From a total of 318 screened glaucoma patients who had undergone at least 3 serial Cirrus HD optical coherence tomography sessions during an 18-month or longer follow-up period, 102 eyes with localized RNFL defects on red-free photographs that did not progress during this period based on stereoscopic disc photography, red-free photography, and standard automated perimetry (SAP) were included. The angular widths from the RNFL thickness deviation maps and average, clock-hour, and quadrant-map thicknesses of the RNFL defects were measured serially to assess intersession variability.
  
  
  METHODS
  Intraclass correlation coefficient (ICC), coefficient of variation (CV), test-retest standard deviation (TRT SD), and tolerance limit.
  
  
  RESULTS
  The ICC, CV, and TRT SD were 0.994, 4.2%, and 1.46°, respectively, for the angular widths; 0.944, 3.1%, and 2.35 μm, respectively, for the average thicknesses; and 0.840 and 0.934, 7.8% and 6.4%, and 7.21 and 5.58 μm, respectively, for the superior and inferior quadrant positions of the RNFL defects. The severity of glaucoma based on the mean deviation of SAP did not affect the reproducibility of the angular widths (TRT SD, 1.3° and 1.84°, respectively; P = 0.905).
  
  
  CONCLUSIONS
  Both the angular widths of RNFL defects in the RNFL thickness deviation map and conventional peripapillary thickness parameters exhibit excellent long-term reproducibility.
  
  
  BACKGROUND
  The author(s) have no proprietary or commercial interest in any materials discussed in this article.
authors: Department of Ophthalmology, Seoul National University Hospital, Jongno-gu, Seoul, Korea.
authors: Kyu Hwa
authors: KH
authors: Roh
authors: Jin Wook
authors: JW
authors: Jeoung
authors: Ki Ho
authors: KH
authors: Park
authors: Beong Wook
authors: BW
authors: Yoo
authors: Dong Myung
authors: DM
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000166:cytology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000592:standards