title: Intestinal absorption rate in children after small intestinal transplantation.
abstract: BACKGROUND
  Small bowel transplantation has now become a recognized treatment of irreversible, permanent, and subtotal intestinal failure.
  
  
  OBJECTIVE
  The aim of this study was to assess intestinal absorption at the time of weaning from parenteral nutrition in a series of children after intestinal transplantation.
  
  
  METHODS
  Twenty-four children (age range: 14-115 mo) received intestinal transplantation, together with the liver in 6 children and the colon in 16 children. Parenteral nutrition was slowly tapered while increasing enteral tube feeding. The absorption rate was measured from a 3-d stool balance analysis performed a few days after the child had weaned from parenteral nutrition to exclusive enteral tube feeding. Results were analyzed according to the resting energy expenditure (REE; Schofield formula).
  
  
  RESULTS
  All children were weaned from parenteral nutrition between 31 and 85 d posttransplantation. Median intakes were as follows: energy, 107 kcal · kg(-1) · d(-1) (range: 79-168 kcal · kg(-1) · d(-1)); lipids, 39 kcal · kg(-1) · d(-1) (range: 20-70 kcal · kg(-1) · d(-1)); and nitrogen, 17 kcal · kg(-1) · d(-1) (range: 11-27 kcal · kg(-1) · d(-1)). Median daily stool output was 998 mL/d (range: 220-2025 mL/d). Median absorption rates were 88% (range: 75-96%) for energy, 82% (range: 55-98%) for lipids, and 77% (range: 61-88%) for nitrogen. The ratios for ingested energy to REE and absorbed energy to REE were 2.2 (range: 1.6-3.6) and 1.8 (range: 1.3-3.3), respectively.
  
  
  CONCLUSIONS
  These data indicate a suboptimal intestinal graft absorption capacity with fat malabsorption, which necessitates energy intakes of at least twice the REE.
authors: Department of Pediatric Gastroenterology, Hepatology, and Nutrition, National Reference Center for Rare Digestive Diseases in Children, APHP, Necker-Enfants Malades Hospital, Paris Descartes University, Paris, France.
authors: Felipe
authors: F
authors: Ordonez
authors: Laurence
authors: L
authors: Barbot-Trystram
authors: Florence
authors: F
authors: Lacaille
authors: Christophe
authors: C
authors: Chardot
authors: Solène
authors: S
authors: Ganousse
authors: Laetitia Marie
authors: LM
authors: Petit
authors: Virginie
authors: V
authors: Colomb-Jung
authors: Emmeline
authors: E
authors: Dalodier
authors: Julie
authors: J
authors: Salomon
authors: Cécile
authors: C
authors: Talbotec
authors: Angelo
authors: A
authors: Campanozzi
authors: Frank
authors: F
authors: Ruemmele
authors: Yann
authors: Y
authors: Révillon
authors: Frédérique
authors: F
authors: Sauvat
authors: Nathalie
authors: N
authors: Kapel
authors: Olivier
authors: O
authors: Goulet
mesh_terms: D000293:Adolescent; D001481:Basal Metabolism; D002648:Child; D002675:Child, Preschool; D003672:Defecation; D004041:Dietary Fats / Q000378:metabolism*; D002149:Energy Intake; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007410:Intestinal Diseases / Q000378:metabolism / Q000601:surgery* / Q000628:therapy; D007421:Intestine, Small / Q000378:metabolism / Q000601:surgery; D009584:Nitrogen / Q000378:metabolism*; D018529:Nutritional Support; D016377:Organ Transplantation; D011183:Postoperative Complications / Q000209:etiology* / Q000378:metabolism; D012778:Short Bowel Syndrome / Q000209:etiology* / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D009584:Nitrogen