title: Optogenetic interrogations of the neural circuits underlying addiction.
abstract: Exposure to addictive drugs can result in maladaptive alterations in neural circuit function. This review highlights recent progress made in identifying the organization, function, and cellular plasticity of the ventral tegmental area (VTA) and nucleus accumbens (NAc), two brain regions strongly implicated in substance use disorders. Emphasis is given to advances made with new research methodologies, particularly optogenetics, which have provided scientists with an unprecedented ability to map neural circuitry and pinpoint drug-induced synaptic modifications. A better understanding of these adaptive events will aid the development of pharmacological treatments for drug addiction and, more generally, further our understanding of motivated behaviors.
authors: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
authors: Jonathan P
authors: JP
authors: Britt
authors: Antonello
authors: A
authors: Bonci
mesh_terms: D000818:Animals; D006801:Humans; D009042:Motivation; D009434:Neural Pathways / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D062308:Optogenetics; D019966:Substance-Related Disorders / Q000473:pathology*; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology
references: Trends Neurosci. 1989 Oct;12(10):366-75
references: 2479133
references: J Neurosci. 2011 May 25;31(21):7811-6
references: 21613494
references: Nature. 1984 Oct 4-10;311(5985):461-4
references: 6207434
references: Front Mol Neurosci. 2012 Jun 27;5:72
references: 22754497
references: Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):713-8
references: 23267100
references: Nature. 2008 Jul 3;454(7200):118-21
references: 18500330
references: Nature. 2011 Jun 29;475(7356):377-80
references: 21716290
references: PLoS One. 2010 Dec 31;5(12):e15870
references: 21209835
references: Neuropsychopharmacology. 2010 Jan;35(1):4-26
references: 19812543
references: Nature. 2011 Dec 07;481(7379):71-5
references: 22158102
references: Front Neurosci. 2012 Sep 25;6:137
references: 23055953
references: Biol Psychiatry. 2012 Jun 15;71(12):1033-8
references: 22480664
references: Biol Psychiatry. 2012 Jun 15;71(12):1061-7
references: 22196983
references: PLoS One. 2012;7(4):e33612
references: 22506004
references: Annu Rev Neurosci. 2011;34:441-66
references: 21469956
references: Curr Protoc Neurosci. 2012;Chapter 2:Unit2.16
references: 23042500
references: Nature. 2010 Jul 29;466(7306):622-6
references: 20613723
references: Brain Struct Funct. 2013 Sep;218(5):1159-76
references: 22926514
references: Neuron. 2012 Jun 7;74(5):858-73
references: 22681690
references: Nature. 2012 Dec 20;492(7429):452-6
references: 23178810
references: Nature. 2012 Jan 18;482(7383):85-8
references: 22258508
references: Science. 2009 May 22;324(5930):1080-4
references: 19389999
references: Cell Rep. 2012 Jul 26;2(1):33-41
references: 22840394
references: Nature. 2009 Apr 23;458(7241):1025-9
references: 19295515
references: IUBMB Life. 2011 Oct;63(10):824-30
references: 21901814
references: PLoS One. 2011 Apr 22;6(4):e19155
references: 21544206
references: Neuron. 2003 Feb 20;37(4):577-82
references: 12597856
references: Amino Acids. 2000;19(1):45-52
references: 11026472
references: J Neurosci. 2012 Oct 24;32(43):15076-85
references: 23100428
references: Neuron. 2012 Jul 12;75(1):58-64
references: 22794260
references: J Neurosci. 2011 Oct 12;31(41):14536-41
references: 21994370
references: Nat Rev Neurosci. 2012 Mar 20;13(4):251-66
references: 22430017
references: J Neurosci. 2011 Feb 2;31(5):1895-904
references: 21289199
references: Neuron. 2011 Jun 9;70(5):855-62
references: 21658580
references: Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18932-7
references: 23112197
references: J Neurosci. 2011 Apr 13;31(15):5737-43
references: 21490215
references: Biol Psychiatry. 2011 Jun 1;69(11):1013-4
references: 21550434
references: Nat Neurosci. 2012 Jun;15(6):816-8
references: 22544310
references: Nat Protoc. 2011 Dec 08;7(1):12-23
references: 22157972
references: Eur J Neurosci. 2011 Apr;33(7):1205-11
references: 21375596
references: Brain Res. 2013 May 20;1511:46-64
references: 23031636
references: Brain Res. 2013 May 20;1511:73-92
references: 23142759
references: Proc Natl Acad Sci U S A. 1988 Jul;85(14):5274-8
references: 2899326
references: Nat Neurosci. 2011 Jan;14(1):22-4
references: 21131952
references: Nat Neurosci. 2011 Dec 11;15(1):123-30
references: 22158514
references: Addict Biol. 2013 Jan;18(1):50-3
references: 22823160
references: Neuron. 2012 Mar 22;73(6):1184-94
references: 22445345
references: Neuron. 2012 Oct 4;76(1):33-50
references: 23040805
references: Science. 2010 Dec 17;330(6011):1677-81
references: 21164015
references: J Neurosci. 2011 Jul 27;31(30):10829-35
references: 21795535
references: Curr Opin Neurobiol. 2011 Jun;21(3):433-9
references: 21420852
references: Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15037-42
references: 21402948
references: Nat Neurosci. 2012 Nov;15(11):1556-62
references: 23023294
references: J Biol Chem. 2012 Sep 14;287(38):31804-12
references: 22843694
references: Neuron. 2012 Mar 22;73(6):1173-83
references: 22445344
references: J Neurosci. 2011 Jan 26;31(4):1183-92
references: 21273403
references: Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20703-8
references: 23184975
references: Neuron. 2012 May 10;74(3):475-81
references: 22578499
references: Brain Res. 2013 May 20;1511:21-32
references: 23178332
references: Front Neural Circuits. 2012 Jul 27;6:47
references: 22866029
references: Neuron. 2011 Dec 8;72(5):721-33
references: 22153370
references: Nature. 2012 Oct 11;490(7419):262-6
references: 23034651
references: Neuron. 2012 Nov 21;76(4):790-803
references: 23177963
references: J Neurosci. 2010 Jun 16;30(24):8229-33
references: 20554874
references: Science. 2010 Oct 15;330(6002):385-90
references: 20947769
references: Nat Neurosci. 2009 Aug;12(8):1069-73
references: 19620976
references: Neurosci Biobehav Rev. 2010 Nov;35(2):185-211
references: 20109488
references: Neuron. 2011 Feb 24;69(4):650-63
references: 21338877
references: Neuron. 2010 Mar 11;65(5):643-56
references: 20223200
references: Nat Neurosci. 2012 Dec;15(12):1624-6
references: 23143514
references: J Neurosci. 2012 Nov 7;32(45):15779-90
references: 23136417
references: Nature. 2001 May 31;411(6837):583-7
references: 11385572
references: Ann N Y Acad Sci. 2012 Feb;1248:71-88
references: 22171551
references: Nat Neurosci. 2012 Sep;15(9):1281-9
references: 22902719
references: Curr Top Behav Neurosci. 2010;3:29-71
references: 21161749
references: Nat Neurosci. 2012 Mar 25;15(5):793-802
references: 22446880
references: Nat Neurosci. 2012 Jun 24;15(8):1105-7
references: 22729176
references: Nature. 2012 Nov 8;491(7423):212-7
references: 23064228
references: Nat Methods. 2011 Dec 18;9(2):159-72
references: 22179551
references: Cold Spring Harb Perspect Med. 2012 Nov 01;2(11):
references: 23043156
references: J Neurosci. 2010 May 19;30(20):7105-10
references: 20484653
references: Physiology (Bethesda). 2012 Jun;27(3):167-77
references: 22689792
references: Addict Biol. 2011 Oct;16(4):519-31
references: 21929708
references: Neuron. 2012 Nov 8;76(3):470-85
references: 23141060