title: Direct use of formamides as amino group sources via C-N bond cleavage: a catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions.
abstract: An efficient and direct use of formamides as amino group sources for the synthesis of α-ketoamides was developed under metal-free conditions. The reaction was based on the oxidative coupling of acetophenones with formamides and generated the desired products in good yields in the presence of t-BuOOH/I(2)/PhCO(2)H.
authors: Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P R China.
authors: Qiong
authors: Q
authors: Zhao
authors: Tao
authors: T
authors: Miao
authors: Xiaobin
authors: X
authors: Zhang
authors: Wei
authors: W
authors: Zhou
authors: Lei
authors: L
authors: Wang
mesh_terms: D000098:Acetophenones / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005559:Formamides / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D020122:tert-Butylhydroperoxide / Q000737:chemistry
chemical_list: D000098:Acetophenones; D000577:Amides; D005559:Formamides; D007659:Ketones; D020122:tert-Butylhydroperoxide; D007455:Iodine