title: [Mesenchymal stem cells in the treatment of chronic liver disease--from experiment to clinical practice].
abstract: The paper presents an analytical review of recent literature on the relevance and perspectives of using of mesenchymal stromal cells (MSCs) in chronic liver disease (CLD). The possible mechanisms of action of stem cells and the results of the original experience of the MSC application in liver cirrhosis of different etiologies are described. Systemic application of stem cells was accompanied by decreasing of clinical and biochemical disease activity, of levels of proinflammatory cytokines, the concentrations of transforming growth factor and procollagen type IV in serum. Anti-inflammatory and antifibrotic effect of MSC is confirmed by morphological examination of liver tissue over time.
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D024142:Collagen Type VI / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000473:pathology / Q000628:therapy*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells; D008875:Middle Aged; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers; D024142:Collagen Type VI; D016207:Cytokines