title: Hospitalizations among people with Down syndrome: a nationwide population-based study in Denmark.
abstract: Most persons with Down syndrome (DS) now survive to adulthood, but their health care needs beyond childhood are not well described. We followed a national cohort of 3,212 persons with DS and a reference cohort of persons without DS through the Danish National Hospital Register from January 1, 1977, to May 31, 2008. Poisson regression was used to calculate rate ratios for numbers of overnight hospital admissions and hospital days. During the study period, persons with DS had more than twice the rate of hospital admissions and nearly three times as many bed-days as the population as a whole. Malformations, diseases of the respiratory system, and diseases of the nervous system or sensory organs were the principal indications for hospital admissions. The higher rate ratios for hospital admissions were seen especially among persons less than 20 years of age. Hospitalizations for neoplasms or for diseases of the musculoskeletal system or connective tissue were much less frequent among adults with DS. As survival among persons with DS continues to improve, these findings are likely to be useful for health care planning, although the potential utility may be different for different health care systems.
authors: Section of Epidemiology, Department of Public Health, University of Aarhus, Denmark. zjl@soci.au.dk
authors: Jin Liang
authors: JL
authors: Zhu
authors: Henrik
authors: H
authors: Hasle
authors: Adolfo
authors: A
authors: Correa
authors: Diana
authors: D
authors: Schendel
authors: J M
authors: JM
authors: Friedman
authors: Jørn
authors: J
authors: Olsen
authors: Sonja A
authors: SA
authors: Rasmussen
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D012042:Registries; D055815:Young Adult
references: Eur J Public Health. 2007 Apr;17(2):221-5
references: 16857692
references: Br J Gen Pract. 2007 Jan;57(534):50-5
references: 17244425
references: Lancet. 2002 Mar 23;359(9311):1019-25
references: 11937181
references: Res Dev Disabil. 2012 Mar-Apr;33(2):435-41
references: 22137940
references: Am J Med Genet. 1998 Jun 5;77(5):431-8
references: 9632176
references: Child Care Health Dev. 1990 Mar-Apr;16(2):83-97
references: 2139819
references: MMWR Morb Mortal Wkly Rep. 2006 Jan 6;54(51):1301-5
references: 16397457
references: Lancet. 2000 Jan 15;355(9199):165-9
references: 10675114
references: Am J Med Genet C Semin Med Genet. 2006 Aug 15;142C(3):131-40
references: 16838306
references: Pediatrics. 2006 Oct;118(4):1633-9
references: 17015556
references: Diabet Med. 1998 Feb;15(2):160-3
references: 9507919
references: Dan Med Bull. 1988 Dec;35(6):585-8
references: 2975584
references: Res Dev Disabil. 2011 Sep-Oct;32(5):1709-13
references: 21458226
references: Dan Med Bull. 1988 Feb;35(1):100-4
references: 2963731
references: Am J Med Genet A. 2008 Dec 1;146A(23):2998-3010
references: 19006076
references: Pediatrics. 2009 Feb;123(2):e253-60
references: 19171577
references: Am J Med Genet A. 2010 Mar;152A(3):800-1
references: 20186777
references: J Pediatr. 2011 Feb;158(2):194-200.e1
references: 20934710
references: Am J Med Genet C Semin Med Genet. 2006 Aug 15;142C(3):141-8
references: 16838307
references: Am J Med Genet. 1999 Jun 25;89(2):100-10
references: 10559765
references: J Intellect Disabil Res. 1993 Dec;37 ( Pt 6):543-51
references: 8124000
references: J Intellect Disabil Res. 2002 May;46(Pt 4):310-7
references: 12000582
references: J Pediatr. 2006 Jun;148(6):806-812
references: 16769392
references: Ment Retard Dev Disabil Res Rev. 2007;13(3):237-46
references: 17910085
references: Disabil Health J. 2011 Apr;4(2):68-77
references: 21419370
references: Clin Genet. 2009 Feb;75(2):180-4
references: 19021635
references: Dev Med Child Neurol. 1999 Oct;41(10):683-8
references: 10587045
references: Dev Med Child Neurol. 2004 Apr;46(4):282-6
references: 15077706
references: J Intellect Disabil Res. 2007 Dec;51(Pt 12):1030-8
references: 17991010
references: Int J Cancer. 2006 Apr 1;118(7):1769-72
references: 16231334
references: Downs Syndr Res Pract. 2008 Oct;12(2):141-7
references: 19026287
references: J Paediatr Child Health. 1999 Aug;35(4):383-6
references: 10457298
references: Pediatr Clin North Am. 2008 Feb;55(1):53-70, x
references: 18242315
references: Genet Med. 2008 Mar;10(3):173-80
references: 18344706