title: [Age-related changes in sensory neurons containing calcitonin gene-related peptide under conditions of afferentation deficit in rats].
abstract: Morphological features of calcitonin gene-related peptide (CGRP)-immunoreactive neurons were studied in the sensory ganglia of the vagus and thoracic nerves in 3-, 10-, 20-, 30-, 60-, 90-, and 120-day-old rats under conditions of chemically-induced deafferentation. We found that, in rats, CGRP-containing neurons appeared in both ganglia immediately after they were born and their number decreased with aging. Most of CGRP-immunoreactive neurons were small in size, i.e., up to 600 microm2. Administration of capsaicin modified age-related changes in the number of CGRP-immunopositive neurons. In the thoracic nerve ganglion, the mean square of these cells and their number substantially decreased, whereas, in the vagus nerve ganglion, positive cells were not observed.
authors: V V
authors: VV
authors: Porseva
authors: A A
authors: AA
authors: Strelkov
authors: V V
authors: VV
authors: Shilkin
authors: P M
authors: PM
authors: Masliukov
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002211:Capsaicin / Q000494:pharmacology; D002452:Cell Count; D048429:Cell Size; D005260:Female; D005727:Ganglia, Spinal / Q000187:drug effects / Q000254:growth & development / Q000648:ultrastructure*; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D007150:Immunohistochemistry; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000235:genetics / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure*; D018689:Sensory System Agents / Q000494:pharmacology; D013900:Thoracic Nerves / Q000187:drug effects / Q000254:growth & development / Q000648:ultrastructure*; D014630:Vagus Nerve / Q000187:drug effects / Q000254:growth & development
chemical_list: D018015:Receptors, Calcitonin Gene-Related Peptide; D018689:Sensory System Agents; D002211:Capsaicin