title: Impact of propofol on mid-latency auditory-evoked potentials in children.
abstract: BACKGROUND
  Propofol is increasingly used in paediatric anaesthesia, but can be challenging to titrate accurately in this group. Mid-latency auditory-evoked potentials (MLAEPs) can be used to help titrate propofol. However, the effects of propofol on MLAEP in children are unclear. Therefore, we investigated the relationship between propofol and MLAEP in children undergoing anaesthesia.
  
  
  METHODS
  Fourteen healthy children aged 4-16 yr received anaesthesia for elective surgery. Before surgery, propofol was administered in three concentrations (3, 6, 9 µg ml(-1)) through a target-controlled infusion pump using Kataria and colleagues' model. MLAEPs were recorded 5 min after having reached each target propofol concentration at each respective concentration. Additionally, venous propofol blood concentrations were assayed at each measuring time point.
  
  
  RESULTS
  Propofol increased all four MLAEP peak latencies (peaks Na, Pa, Nb, P1) in a dose-dependent manner. In addition, the differences in amplitudes were significantly smaller with increasing propofol target concentrations. The measured propofol plasma concentrations correlated positively with the latencies of the peaks Na, Pa, and Nb.
  
  
  CONCLUSIONS
  Propofol affects MLAEP latencies and amplitudes in children in a dose-dependent manner. MLAEP measurement might therefore be a useful tool for monitoring depth of propofol anaesthesia in children.
authors: Clinic of Anaesthesiology, SRH Wald-Klinikum Gera GmbH, Straße des Friedens 122, 07548 Gera, Germany.
authors: G E
authors: GE
authors: Kuhnle
authors: C
authors: C
authors: Hornuss
authors: M
authors: M
authors: Lenk
authors: A P
authors: AP
authors: Salam
authors: D
authors: D
authors: Wiepcke
authors: V
authors: V
authors: Edelmann-Gahr
authors: G
authors: G
authors: Flake
authors: M
authors: M
authors: Daunderer
authors: M
authors: M
authors: Oberhauser
authors: H-H
authors: HH
authors: Müller
authors: M
authors: M
authors: Feuerecker
mesh_terms: D000293:Adolescent; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D015742:Propofol / Q000097:blood / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol
keywords: monitoring, auditory-evoked potentials; paediatric anaesthesia; propofol