title: Association study of 71 European Crohn's disease susceptibility loci in a Japanese population.
abstract: BACKGROUND
  A large-scale meta-analysis of a series of European genome-wide association studies revealed 71 susceptibility loci for Crohn's disease (CD). However, it is not clear whether these susceptibility loci are also shared with Japanese populations.
  
  
  METHODS
  We genotyped 71 single-nucleotide polymorphisms (SNPs) comprising 1311 CD cases and 6585 controls of Japanese descent, and their associations with CD were evaluated using the Cochran-Armitage trend test. In addition, genotype-phenotype analyses were conducted on the SNPs showing associations with Japanese CD based on the Montreal classification.
  
  
  RESULTS
  Twenty-seven SNPs showed at least nominal association (P < 0.05) and 11 of them remained significant even after Bonferroni correction (P < 0.0007). Despite high statistical power, we could not find any association in 17 loci. Moreover, SNPs in 9 loci were rare or absent in the Japanese population. Genetic variations involved in the innate immune system (NOD2, ATG16L1, and IRGM) showed no association with CD susceptibility in the Japanese population. Genotype-phenotype analyses showed that rs3810936, a marker of TNFSF15, correlated with severe CD phenotypes.
  
  
  CONCLUSIONS
  Our study suggests that there is a differential genetic background of CD susceptibility between Japanese and European populations.
authors: Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN Yokohama Institute, Yokohama, Japan.
authors: Atsushi
authors: A
authors: Hirano
authors: Keiko
authors: K
authors: Yamazaki
authors: Junji
authors: J
authors: Umeno
authors: Kyota
authors: K
authors: Ashikawa
authors: Masayuki
authors: M
authors: Aoki
authors: Takayuki
authors: T
authors: Matsumoto
authors: Shotaro
authors: S
authors: Nakamura
authors: Toshiharu
authors: T
authors: Ninomiya
authors: Toshiyuki
authors: T
authors: Matsui
authors: Fumihito
authors: F
authors: Hirai
authors: Takaaki
authors: T
authors: Kawaguchi
authors: Masakazu
authors: M
authors: Takazoe
authors: Hiroki
authors: H
authors: Tanaka
authors: Satoshi
authors: S
authors: Motoya
authors: Yutaka
authors: Y
authors: Kiyohara
authors: Takanari
authors: T
authors: Kitazono
authors: Yusuke
authors: Y
authors: Nakamura
authors: Naoyuki
authors: N
authors: Kamatani
authors: Michiaki
authors: M
authors: Kubo
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003424:Crohn Disease / Q000235:genetics*; D005060:Europe; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012720:Severity of Illness Index; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15 / Q000235:genetics
chemical_list: D005819:Genetic Markers; C117026:TNFSF15 protein, human; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15