title: [TREK1 potassium channels and depression].
abstract: Major depression disorder is an increasing heavy burden in modem society, but its pathological mechanism is still vague. Recent evidence indicated that two pore potassium channel, TREK1, is one of the important drug targets of antidepressants. The structural and functional research progress of TREK1 potassium channel were reviewed with an emphasis on its roles in anti-depression, neuronal protection, and neuronal plasticity. The complicated interactions between TREK1 potassium channel and monoamine transmitters-receptors were also reviewed and future directions to explore the underline mechanism were also discussed.
authors: Institute of Neurology and Psychiatry, Southeast University, Nanjing 210009, China.
authors: Dong-Qing
authors: DQ
authors: Ye
authors: Zhi-Jun
authors: ZJ
authors: Zhang
authors: Yang
authors: Y
authors: Li
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D003865:Major Depressive Disorder / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D016503:Drug Delivery Systems; D055786:Gene Knockout Techniques; D006801:Humans; D009473:Neuronal Plasticity; D011110:Polymorphism, Genetic; D024683:Potassium Channels, Tandem Pore Domain / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D011985:Receptors, Serotonin / Q000378:metabolism; D044422:Receptors, Serotonin, 5-HT4; D012701:Serotonin / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D024683:Potassium Channels, Tandem Pore Domain; D011985:Receptors, Serotonin; C103742:potassium channel protein TREK-1; D044422:Receptors, Serotonin, 5-HT4; D012701:Serotonin