title: Genetic expression profiles of adult and pediatric ependymomas: molecular pathways, prognostic indicators, and therapeutic targets.
abstract: Ependymomas are tumors that can present within either the intracranial or spinal regions. While 90% of all pediatric ependymomas are intracranial, spinal cord ependymomas are more commonly found in patients 20-40 years old. Treatment for spinal lesions has achieved local control rates up to 100% following gross total resection, while pediatric intracranial tumors have 40-60% mortality. Given the inability to effectively treat ependymomas with current standard practices, researchers have focused their efforts on evaluating chromosomal alterations, genetic expression profiles, epigenetic events, and molecular pathways. While these studies have provided critical insight into the potential mechanisms underlying ependymoma pathogenesis, understanding of the intricate interplay between the various pathways involved in tumor initiation, development, and progression will require deeper investigation. However, several potential prognostic markers and therapeutic targets have been identified, providing key areas of focus for future research. The utilization of unique genetic expression profiles based upon patient age, tumor location, tumor grade, and subtype has revealed a multitude of findings warranting further study. Inspection of various molecular pathways associated with ependymomas may establish the foundation for developing novel therapies capable of achieving significant clinical improvements with individualized regimens specifically designed for personalized treatment strategies.
authors: UCLA Department of Neurosurgery, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, United States.
authors: Daniel T
authors: DT
authors: Nagasawa
authors: Andy
authors: A
authors: Trang
authors: Winward
authors: W
authors: Choy
authors: Marko
authors: M
authors: Spasic
authors: Andrew
authors: A
authors: Yew
authors: Golmah
authors: G
authors: Zarinkhou
authors: Heather M
authors: HM
authors: Garcia
authors: Isaac
authors: I
authors: Yang
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000235:genetics / Q000628:therapy; D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000628:therapy*; D002648:Child; D016172:DNA Fingerprinting; D004806:Ependymoma / Q000235:genetics* / Q000628:therapy*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D053858:Metabolic Networks and Pathways; D011379:Prognosis; D013125:Spinal Neoplasms / Q000235:genetics / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents