title: Maternal seizure disorder and risk of adverse pregnancy outcomes.
abstract: OBJECTIVE
  We sought to estimate the association between maternal seizure disorder and adverse pregnancy outcomes.
  
  
  METHODS
  We performed a retrospective cohort study of singleton, nonanomalous pregnancies. Women with self-reported seizure disorder were compared to women without medical problems. The primary outcome was intrauterine growth restriction (IUGR) <10th percentile. Secondary outcomes included IUGR <5th percentile, stillbirth, preeclampsia, and preterm delivery. A sensitivity analysis was performed using women who reported using antiepileptics to estimate the impact of disease severity on pregnancy outcomes.
  
  
  RESULTS
  Of 47,118 women, 440 reported a seizure disorder. Women with seizure disorder were not at increased risk of IUGR <10th percentile (adjusted odds ratio, 1.11; 95% confidence interval, 0.82-1.50), IUGR <5th percentile, stillbirth, preeclampsia, or preterm delivery. The results were similar in the sensitivity analysis of women taking antiseizure medications.
  
  
  CONCLUSIONS
  Our results suggest women with a seizure disorder are not at increased risk of IUGR, stillbirth, preeclampsia, or preterm delivery.
authors: Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. mcphersonj@wudosis.wustl.edu
authors: Jessica A
authors: JA
authors: McPherson
authors: Lorie M
authors: LM
authors: Harper
authors: Anthony O
authors: AO
authors: Odibo
authors: Kimberly A
authors: KA
authors: Roehl
authors: Alison G
authors: AG
authors: Cahill
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D016022:Case-Control Studies; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005317:Fetal Growth Retardation; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D057566:Self Report; D012720:Severity of Illness Index; D050497:Stillbirth / Q000453:epidemiology
chemical_list: D000927:Anticonvulsants