title: Highly potent and selective cannabinoid receptor 2 agonists: initial hit optimization of an adamantyl hit series identified from high-through-put screening.
abstract: A series of highly potent & selective adamantane derived CB2 agonists was identified in a high-throughput screen. A SAR was established and physicochemical properties were significantly improved. This was accompanied by potency of the compounds on the Q63R variant and varying β-arrestin data which will support the insight into their relevance for the in vivo situation.
authors: F. Hoffmann-La Roche Ltd, Pharma Research & Early Development, Medicinal Chemistry, Grenzacher Str. 124, 4070 Basel, Switzerland. matthias.nettekoven@roche.com
authors: Matthias
authors: M
authors: Nettekoven
authors: Jürgen
authors: J
authors: Fingerle
authors: Uwe
authors: U
authors: Grether
authors: Sabine
authors: S
authors: Grüner
authors: Atsushi
authors: A
authors: Kimbara
authors: Bernd
authors: B
authors: Püllmann
authors: Mark
authors: M
authors: Rogers-Evans
authors: Stephan
authors: S
authors: Röver
authors: Franz
authors: F
authors: Schuler
authors: Tanja
authors: T
authors: Schulz-Gasch
authors: Christoph
authors: C
authors: Ullmer
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D063386:Cannabinoid Receptor Agonists / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D057166:High-Throughput Screening Assays / Q000379:methods; D006801:Humans; D008958:Models, Molecular; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D063386:Cannabinoid Receptor Agonists; D043885:Receptor, Cannabinoid, CB2; D000218:Adamantane