title: MicroRNAs: regulators of neuronal fate.
abstract: Mammalian neural development has been traditionally studied in the context of evolutionarily conserved signaling pathways and neurogenic transcription factors. Recent studies suggest that microRNAs, a group of highly conserved noncoding regulatory small RNAs also play essential roles in neural development and neuronal function. A part of their action in the developing nervous system is to regulate subunit compositions of BAF complexes (ATP-dependent chromatin remodeling complexes), which appear to have dedicated functions during neural development. Intriguingly, ectopic expression of a set of brain-enriched microRNAs, miR-9/9* and miR-124 that promote the assembly of neuron-specific BAF complexes, converts the nonneuronal fate of human dermal fibroblasts towards postmitotic neurons, thereby revealing a previously unappreciated instructive role of these microRNAs. In addition to these global effects, accumulating evidence indicates that many microRNAs could also function locally, such as at the growth cone or at synapses modulating synaptic activity and neuronal connectivity. Here we discuss some of the recent findings about microRNAs' activity in regulating various developmental stages of neurons.
authors: Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors: Alfred X
authors: AX
authors: Sun
authors: Gerald R
authors: GR
authors: Crabtree
authors: Andrew S
authors: AS
authors: Yoo
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism; D065150:Cellular Reprogramming; D042002:Chromatin Assembly and Disassembly; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D055495:Neurogenesis / Q000235:genetics*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors
references: Cell Stem Cell. 2011 Aug 5;9(2):113-8
references: 21802386
references: J Neurosci. 2011 Jan 19;31(3):809-18
references: 21248104
references: Nat Struct Mol Biol. 2009 Apr;16(4):365-71
references: 19330006
references: Cell. 2012 Apr 27;149(3):515-24
references: 22541426
references: Science. 2007 Aug 31;317(5842):1220-4
references: 17761882
references: Neuron. 2010 Mar 11;65(5):597-611
references: 20223197
references: Nucleic Acids Res. 2010 Jun;38(11):3780-93
references: 20176573
references: BMC Genomics. 2010 Jun 30;11:409
references: 20591156
references: Genes Dev. 2007 Apr 1;21(7):744-9
references: 17403776
references: Neuron. 2010 Mar 11;65(5):612-26
references: 20223198
references: J Neurosci. 2012 Aug 8;32(32):10887-94
references: 22875923
references: Nature. 2011 Jul 13;476(7359):228-31
references: 21753754
references: Nat Rev Genet. 2012 Mar 13;13(4):271-82
references: 22411466
references: Neuron. 2012 Aug 9;75(3):363-79
references: 22884321
references: Nature. 2005 Feb 17;433(7027):769-73
references: 15685193
references: Development. 2008 Dec;135(23):3911-21
references: 18997113
references: J Neurosci. 2008 Dec 31;28(53):14341-6
references: 19118166
references: Neuron. 2007 Oct 4;56(1):94-108
references: 17920018
references: Nat Biotechnol. 2011 Oct;29(10):892-907
references: 21997635
references: Dev Dyn. 2009 Nov;238(11):2800-12
references: 19806666
references: Mol Cell Biol. 2010 May;30(10):2508-17
references: 20308325
references: J Neurosci. 2011 Mar 2;31(9):3407-22
references: 21368052
references: J Exp Med. 2007 Jul 9;204(7):1553-8
references: 17606634
references: Development. 2012 Apr;139(8):1427-34
references: 22378639
references: RNA. 2011 Aug;17(8):1489-501
references: 21712401
references: Nature. 2008 Oct 23;455(7216):1124-8
references: 18806776
references: J Neurosci. 2008 Oct 8;28(41):10415-21
references: 18842901
references: Neuron. 2009 Sep 24;63(6):803-17
references: 19778509
references: Stem Cell Rev Rep. 2012 Dec;8(4):1129-37
references: 23054963
references: Nat Cell Biol. 2010 Jan;12(1):31-40; sup pp 1-9
references: 20010817
references: Nat Neurosci. 2009 Apr;12(4):399-408
references: 19287386
references: Int J Cancer. 2009 Feb 1;124(3):568-77
references: 18973228
references: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2422-7
references: 16461918
references: PLoS Genet. 2012 Feb;8(2):e1002515
references: 22347817
references: Aging (Albany NY). 2010 Jul;2(7):415-31
references: 20634564
references: Nucleic Acids Res. 2010 Nov;38(20):6895-905
references: 20624818
references: J Neurosci. 2012 Jun 27;32(26):8879-89
references: 22745489
references: Nature. 2006 Jan 19;439(7074):283-9
references: 16421561
references: Mol Cell. 2007 Aug 3;27(3):435-48
references: 17679093
references: Nat Neurosci. 2011 Aug 21;14(9):1125-34
references: 21857657
references: Nature. 2009 Jul 30;460(7255):642-6
references: 19561591
references: Stem Cells. 2010 Jun;28(6):1060-70
references: 20506192
references: Cell. 2008 Oct 17;135(2):227-39
references: 18957199
references: J Cell Sci. 2010 Feb 15;123(Pt 4):586-94
references: 20103535
references: J Cell Biol. 2010 Apr 5;189(1):127-41
references: 20368621
references: Nat Neurosci. 2010 Oct;13(10):1181-9
references: 20871603
references: Nat Neurosci. 2012 Apr 08;15(5):697-699
references: 22484572
references: Neuron. 2007 Jul 19;55(2):201-15
references: 17640523
references: Neuron. 2012 Jan 12;73(1):35-48
references: 22243745
references: Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1876-81
references: 20133835
references: Nat Commun. 2011 Nov 08;2:529
references: 22068596
references: Nat Neurosci. 2012 Jun 24;15(8):1120-6
references: 22729175
references: Cell Stem Cell. 2010 May 7;6(5):433-44
references: 20452318
references: Oncogene. 2010 Apr 15;29(15):2161-4
references: 20190803
references: Oncogene. 2010 Apr 15;29(15):2302-8
references: 20190813
references: Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13111-6
references: 20616011
references: Cell Rep. 2012 Jul 26;2(1):10-8
references: 22840391
references: Cell. 2009 Mar 6;136(5):913-25
references: 19269368