title: An emerging role for Wnt and GSK3 signaling pathways in schizophrenia.
abstract: Schizophrenia is a disabling illness with limited treatment options. The underlying pathophysiology remains unknown, partially due to its heterogeneous nature, and a lack of understanding of the biological functions of genetic risk factors. Several signaling pathways have been implicated, however, with the varying degrees of support. In this article, I will focus on the converging evidence supporting a prominent role for Wnt and glycogen synthase kinase 3 (GSK3) signaling in the biological bases of schizophrenia. This includes current pharmacological therapies that target GSK3, animal model and cell-based studies, and recent human genetic findings that implicate Wnt and GSK3 signaling.
authors: Department of Biochemistry and Biomedical Sciences, Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada. singhk2@mcmaster.ca
authors: K K
authors: KK
authors: Singh
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use; D056915:DNA Copy Number Variations; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008957:Models, Genetic; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D060449:Wnt Signaling Pathway / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D051155:Wnt1 Protein / Q000235:genetics* / Q000378:metabolism; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins; D011954:Receptors, Dopamine; D051155:Wnt1 Protein; D051176:beta Catenin; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3