title: Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors.
abstract: The Rab27 family of GTPases regulates the efficiency and specificity of exocytosis in hematopoietic cells, including neutrophils, CTLs, NK cells, and mast cells. However, the mechanisms regulated by Rab27 GTPases are cell-specific, as they depend on the differential expression and function of particular effector molecules that are recruited by the GTPases. In addition, Rab27 GTPases participate in multiple steps of the regulation of the secretory process, including priming, tethering, docking, and fusion through sequential interaction with multiple effector molecules. Finally, recent reports suggest that Rab27 GTPases and their effectors regulate vesicular trafficking mechanisms other than exocytosis, including endocytosis and phagocytosis. This review focuses on the latest discoveries on the function of Rab27 GTPases and their effectors Munc13-4 and Slp1 in neutrophil function comparatively to their functions in other leukocytes.
authors: 1.The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA. scatz@scripps.edu; Twitter: http://www.scripps.edu/catz/
authors: Sergio Daniel
authors: SD
authors: Catz
mesh_terms: D000818:Animals; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000201:enzymology / Q000473:pathology; D007249:Inflammation / Q000201:enzymology / Q000473:pathology; D007962:Leukocytes / Q000378:metabolism*; D021381:Protein Transport; D022161:Transport Vesicles / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D020691:rab GTP-Binding Proteins
keywords: Munc13-4; exocytosis, phagocytosis; inflammation; innate immunity; synaptotagmin-like protein
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