title: Clinical efficacy of a silver-releasing foam dressing in venous leg ulcer healing: a randomised controlled trial.
abstract: Biatain and Biatain-Ag are two identical wound dressings except the fact that Biatain-Ag releases silver. In the present multinational double-blinded randomised controlled trial the effect of the two dressings were compared for treatment of venous leg ulcers. A total of 181 patients were treated for 6 weeks with either Biatain or Biatain-Ag followed by 4 weeks treatment with Biatain. Biatain-Ag showed superior performance in relative wound area reduction after 6 weeks treatment and the estimated treatment difference increased after 10 weeks indicating that the effect of silver continues at least for 4 weeks after treatment. A subgroup of the patients differed significantly from the others with respect to parameters associated with a poor healing prognosis; patients were older, had significant history of venous thrombosis, larger ulcers with longer duration and more often recurrent. For this subgroup of patients Biatain-Ag showed significant (P < 0·05) better performance in terms of relative ulcer area reduction and healing rate. In conclusion, this study suggests the superior performance of Biatain-Ag compared with the non silver-releasing dressing Biatain in particular for patients having ulcers associated with a poor healing prognosis.
authors: Département de Dermatologie, UF de Dermatologie Vasculaire, Assistance-Publique Hôpitaux de Paris, Hôspital Tenon, Paris, France.
authors: Patricia
authors: P
authors: Senet
authors: Renzo
authors: R
authors: Bause
authors: Bo
authors: B
authors: Jørgensen
authors: Karsten
authors: K
authors: Fogh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011140:Polyurethanes; D018030:Silver Compounds / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000628:therapy*; D014945:Wound Healing
chemical_list: D011140:Polyurethanes; D018030:Silver Compounds
keywords: Delayed healing; Randomised double-blinded clinical trial; Silver foam dressing; Venous leg ulcers; Wound area regression
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