title: Low birth weight: is it related to assisted reproductive technology or underlying infertility?
abstract: Since 1978, we have witnessed a successful evolution of assisted reproductive technology (ART), with improvement of the pregnancy rates and a growing demand. However, in recent years, there has been increasing concern regarding its safety due to the potential health impact on its infants. The raise of the developmental origins of adult disease has positioned low birth weight (LBW) as a significant health issue. Although multiple studies have associated ART with LBW, the etiology of this association remains largely unknown. We review the potential association between different components of ART and infertility with LBW, while acknowledging the limitations of interpretation of the existing literature.
authors: Section of Reproductive Endocrinology and Infertility, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA. laxmi.kondapalli@ucdenver.edu
authors: Laxmi A
authors: LA
authors: Kondapalli
authors: Alfredo
authors: A
authors: Perales-Puchalt
mesh_terms: D000328:Adult; D015984:Causality; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007246:Infertility / Q000453:epidemiology* / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D018570:Risk Assessment
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