title: Maxillary sinus grafting with biphasic calcium phosphate ceramics: clinical and histologic evaluation in man.
abstract: OBJECTIVE
  To evaluate the clinical and histologic aspects of bone formation in maxillary sinus augmentation using macroporous biphasic calcium phosphate (MBCP) comprising hydroxyapatite/tricalcium phosphate (HA/TCP) 60/40 as bone-grafting material.
  
  
  METHODS
  A total of 10 patients and 12 sinuses grafted with MBCP in two-stage sinus augmentation were included in the present study. After a healing period of 6 months, bone core biopsies were harvested during implant insertion and evaluated under light microscopy.
  
  
  RESULTS
  The histologic examination showed that the MBCP particles were in close contact with new bone in all biopsies. Histomorphometric evaluation demonstrated that newly formed bone constituted 28.3% ± 2.7%, residual grafted material 27.3% ± 1.2%, and marrow spaces 45.9% ± 1.9%.
  
  
  CONCLUSIONS
  Histologic investigation showed that the MBCP grafted particles were embedded and integrated in the newly formed bone; this bone was in close and tight contact with the biomaterial particles. Data from the preliminary results demonstrated that MBCP is a biocompatible and osteoconductive material that can be successfully used as a grafting material for sinus floor augmentation.
authors: Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy.
authors: Carlo
authors: C
authors: Mangano
authors: Vittoria
authors: V
authors: Perrotti
authors: Jamil A
authors: JA
authors: Shibli
authors: Francesco
authors: F
authors: Mangano
authors: Laura
authors: L
authors: Ricci
authors: Adriano
authors: A
authors: Piattelli
authors: Giovanna
authors: G
authors: Iezzi
mesh_terms: D000328:Adult; D000368:Aged; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D002516:Ceramics / Q000627:therapeutic use*; D017886:Durapatite; D005260:Female; D006801:Humans; D006882:Hydroxyapatites / Q000627:therapeutic use*; D008297:Male; D008443:Maxillary Sinus / Q000166:cytology; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D059546:Sinus Floor Augmentation / Q000379:methods*; D014945:Wound Healing
chemical_list: D018786:Bone Substitutes; D006882:Hydroxyapatites; C074950:hydroxyapatite-beta tricalcium phosphate; D017886:Durapatite