title: Age-related normal structural and functional ventricular values in cardiac function assessed by magnetic resonance.
abstract: BACKGROUND
  The heart is subject to structural and functional changes with advancing age. However, the magnitude of cardiac age-dependent transformation has not been conclusively elucidated.
  
  
  METHODS
  This retrospective cardiac magnetic resonance (CMR) study included 183 subjects with normal structural and functional ventricular values. End systolic volume (ESV), end diastolic volume (EDV), and ejection fraction (EF) were obtained from the left and the right ventricle in breath-hold cine CMR. Patients were classified into four age groups (20-29, 30-49, 50-69, and ≥70 years) and cardiac measurements were compared using Pearson's rank correlation over the four different groups.
  
  
  RESULTS
  With advanced age a slight but significant decrease in ESV (r=-0.41 for both ventricles, P<0.001) and EDV (r=-0.39 for left ventricle, r=-0.35 for right ventricle, P<0.001) were observed associated with a significant increase in left (r=0.28, P<0.001) and right (r=0.27, P<0.01) ventricular EF reaching a maximal increase in EF of +8.4% (P<0.001) for the left and +6.1% (P<0.01) for the right ventricle in the oldest compared to the youngest patient group. Left ventricular myocardial mass significantly decreased over the four different age groups (P<0.05).
  
  
  CONCLUSIONS
  The aging process is associated with significant changes in left and right ventricular EF, ESV and EDV in subjects with no cardiac functional and structural abnormalities. These findings underline the importance of using age adapted values as standard of reference when evaluating CMR studies.
authors: Department of Radiology, Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland.
authors: Michael
authors: M
authors: Fiechter
authors: Tobias A
authors: TA
authors: Fuchs
authors: Catherine
authors: C
authors: Gebhard
authors: Julia
authors: J
authors: Stehli
authors: Bernd
authors: B
authors: Klaeser
authors: Barbara E
authors: BE
authors: Stähli
authors: Robert
authors: R
authors: Manka
authors: Costantina
authors: C
authors: Manes
authors: Felix C
authors: FC
authors: Tanner
authors: Oliver
authors: O
authors: Gaemperli
authors: Philipp A
authors: PA
authors: Kaufmann
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D000465:Algorithms; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016277:Ventricular Function, Left / Q000502:physiology*
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