title: Antidepressant abietane diterpenoids from Chinese eaglewood.
abstract: Ten new abietane diterpenoids, aquilarabietic acids A-J (1-10), and a new podocarpane diterpenoid, aquilarabietic acid K (11), were isolated from the petroleum ether and ethanol extracts of Chinese eaglewood. Among them, 3, 9, and 10 are artifacts. Their structures were established on the basis of data from extensive spectroscopic and X-ray diffraction analyses. Bioassay results indicated that 1 at 10 μM demonstrated remarkable antidepressant activity in vitro by inhibiting norepinephrine reuptake in rat brain synaptosomes by 81.4% and with an IC(50) value of 9.1 × 10(-7) M.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors: Lin
authors: L
authors: Yang
authors: Lirui
authors: L
authors: Qiao
authors: Chengxue
authors: C
authors: Ji
authors: Dan
authors: D
authors: Xie
authors: Ning-Bo
authors: NB
authors: Gong
authors: Yang
authors: Y
authors: Lu
authors: Jianjun
authors: J
authors: Zhang
authors: Jungui
authors: J
authors: Dai
authors: Shunxing
authors: S
authors: Guo
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000928:Antidepressive Agents; D004365:Drugs, Chinese Herbal; D009638:Norepinephrine