title: Complement-targeted therapeutics in periodontitis.
abstract: Periodontitis is a prevalent oral chronic inflammatory disease which, in severe forms, may exert a major impact on systemic health. Clinical and histological observations, as well as experimental animal studies, suggest involvement of the complement system in periodontitis. However, the precise roles of the various complement components and pathways in periodontitis have only recently started to be elucidated. In this chapter, we review recent progress in the field and discuss the potential of complement-targeted therapeutics in the treatment of periodontitis.
authors: Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. geoh@upenn.edu
authors: George
authors: G
authors: Hajishengallis
authors: John D
authors: JD
authors: Lambris
mesh_terms: D000818:Animals; D015936:Complement C5a / Q000502:physiology; D003165:Complement System Proteins / Q000502:physiology*; D006801:Humans; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D011951:Receptors, Complement / Q000502:physiology
chemical_list: D011951:Receptors, Complement; D015936:Complement C5a; D003165:Complement System Proteins
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