title: Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan.
abstract: BACKGROUND
  A prophylactic antibiotic is recommended to reduce infection-related complication following cesarean delivery. There is a current debate on the time of prophylactic antibiotic in cesarean delivery.
  
  
  METHODS
  An opened randomized, controlled clinical trial was conducted at Soba hospital, Sudan to investigate the timing (pre-incision or after clamping of the umbilical cord) of ceftizoxime for elective cesarean delivery. The outcome measures were; the incidence of post-cesarean febrile and infection-related morbidity and neonatal outcomes between the two groups.
  
  
  RESULTS
  Hundred -eighty women (90 women in each arm of the study) received intravenous injection of 1 g of ceftizoxime as single dose either at pre-incision or after clamping of the umbilical cord. None of the women in either group had endometritis. One woman in the pre-incision group had chest infection. There was no significant difference in the incidence of wound infection between the two groups, 8 (6.7%) vs. 3 (3.3%); P = 0.2. Two babies in the pre-incision group (P = 0.497) had a low Apgar score (< 8) at 1 min. Similar number of neonate (15 in each arm) was admitted to nursery. There were no significant difference in the neonatal jaundice between the two groups, 5 (5.5%) vs. 4 (4.4%), P = 0.2. There was no perinatal death.
  
  
  CONCLUSIONS
  There was no difference in the two regimens (pre-incision or post-clamping of the umbilical cord) of ceftizoxime as prophylactic for elective cesarean delivery.
  
  
  BACKGROUND
  NCT01347593.
authors: Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
authors: Bashier
authors: B
authors: Osman
authors: Amna
authors: A
authors: Abbas
authors: Mohamed A
authors: MA
authors: Ahmed
authors: Magid S
authors: MS
authors: Abubaker
authors: Ishag
authors: I
authors: Adam
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D015296:Ceftizoxime / Q000008:administration & dosage*; D002585:Cesarean Section / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D011247:Pregnancy; D013397:Sudan; D013530:Surgical Wound Infection / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D015296:Ceftizoxime
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