title: Circulatory hepcidin is associated with the anti-inflammatory response but not with iron or anemic status in childhood malaria.
abstract: Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood. Therefore, it is important to understand the pathology underlying the development of CM and SMA as opposed to uncomplicated malaria (UM). Increased levels of hepcidin have been associated with UM, but its level and role in severe malarial disease remains to be investigated. Plasma and clinical data were obtained as part of a prospective case-control study of severe childhood malaria at the main tertiary hospital of the city of Ibadan, Nigeria. Here, we report that hepcidin levels are lower in children with SMA or CM than in those with milder outcome (UM). While different profiles of pro- and anti-inflammatory cytokines were observed between the malaria syndromes, circulatory hepcidin levels remained associated with the levels of its regulatory cytokine interleukin-6 and of the anti-inflammatory cytokine inerleukin-10, irrespective of iron status, anemic status, and general acute-phase response. We propose a role for hepcidin in anti-inflammatory processes in childhood malaria.
authors: Division of Parasitology, Medical Research Council National Institute for Medical Research, London, UK.
authors: Florence
authors: F
authors: Burté
authors: Biobele J
authors: BJ
authors: Brown
authors: Adebola E
authors: AE
authors: Orimadegun
authors: Wasiu A
authors: WA
authors: Ajetunmobi
authors: Nathaniel K
authors: NK
authors: Afolabi
authors: Francis
authors: F
authors: Akinkunmi
authors: Olayinka
authors: O
authors: Kowobari
authors: Samuel
authors: S
authors: Omokhodion
authors: Kikelomo
authors: K
authors: Osinusi
authors: Felix O
authors: FO
authors: Akinbami
authors: Wuraola A
authors: WA
authors: Shokunbi
authors: Olugbemiro
authors: O
authors: Sodeinde
authors: Delmiro
authors: D
authors: Fernandez-Reyes
mesh_terms: D000740:Anemia / Q000097:blood / Q000150:complications; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood; D006400:Hematocrit; D064451:Hepcidins; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000097:blood; D016014:Linear Models; D016779:Malaria, Cerebral / Q000097:blood* / Q000150:complications; D016778:Malaria, Falciparum / Q000097:blood* / Q000150:complications; D008297:Male; D009549:Nigeria; D011446:Prospective Studies; D011990:Receptors, Transferrin / Q000097:blood; D062606:Tertiary Care Centers; D014168:Transferrin / Q000032:analysis
chemical_list: D023181:Antimicrobial Cationic Peptides; D016207:Cytokines; C578702:HAMP protein, human; D064451:Hepcidins; D018836:Inflammation Mediators; D015850:Interleukin-6; D011990:Receptors, Transferrin; D014168:Transferrin; D016753:Interleukin-10; D005293:Ferritins; D007501:Iron
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