title: Relationship between Biomechanical Characteristics of Spinal Manipulation and Neural Responses in an Animal Model: Effect of Linear Control of Thrust Displacement versus Force, Thrust Amplitude, Thrust Duration, and Thrust Rate.
abstract: High velocity low amplitude spinal manipulation (HVLA-SM) is used frequently to treat musculoskeletal complaints. Little is known about the intervention's biomechanical characteristics that determine its clinical benefit. Using an animal preparation, we determined how neural activity from lumbar muscle spindles during a lumbar HVLA-SM is affected by the type of thrust control and by the thrust's amplitude, duration, and rate. A mechanical device was used to apply a linear increase in thrust displacement or force and to control thrust duration. Under displacement control, neural responses during the HVLA-SM increased in a fashion graded with thrust amplitude. Under force control neural responses were similar regardless of the thrust amplitude. Decreasing thrust durations at all thrust amplitudes except the smallest thrust displacement had an overall significant effect on increasing muscle spindle activity during the HVLA-SMs. Under force control, spindle responses specifically and significantly increased between thrust durations of 75 and 150 ms suggesting the presence of a threshold value. Thrust velocities greater than 20-30 mm/s and thrust rates greater than 300 N/s tended to maximize the spindle responses. This study provides a basis for considering biomechanical characteristics of an HVLA-SM that should be measured and reported in clinical efficacy studies to help define effective clinical dosages.
authors: Palmer College of Chiropractic, Palmer Center for Chiropractic Research, Davenport, IA 52803, USA.
authors: William R
authors: WR
authors: Reed
authors: Dong-Yuan
authors: DY
authors: Cao
authors: Cynthia R
authors: CR
authors: Long
authors: Gregory N
authors: GN
authors: Kawchuk
authors: Joel G
authors: JG
authors: Pickar
references: J Physiol. 1967 Oct;192(3):773-800
references: 4293790
references: J Manipulative Physiol Ther. 1989 Feb;12(1):26-37
references: 2926284
references: J Manipulative Physiol Ther. 2010 Oct;33(8):585-93
references: 21036280
references: J Neurosci Methods. 1999 Jul 15;89(2):87-96
references: 10491938
references: J Am Osteopath Assoc. 1975 Mar;74(7):638-50
references: 124754
references: J Manipulative Physiol Ther. 2003 Mar-Apr;26(3):131-8
references: 12704305
references: J Electromyogr Kinesiol. 2012 Oct;22(5):732-9
references: 22542770
references: Spine J. 2002 Sep-Oct;2(5):357-71
references: 14589467
references: J Manipulative Physiol Ther. 1992 Jun;15(5):275-8
references: 1613409
references: J Manipulative Physiol Ther. 2000 Jul-Aug;23(6):380-94
references: 10951308
references: Clin Biomech (Bristol, Avon). 2006 Mar;21(3):254-62
references: 16378668
references: J Manipulative Physiol Ther. 1986 Mar;9(1):15-21
references: 3701223
references: J Manipulative Physiol Ther. 2001 Jan;24(1):2-11
references: 11174689
references: J Manipulative Physiol Ther. 1990 Oct;13(8):448-53
references: 2146356
references: Spine J. 2004 Sep-Oct;4(5):557-63
references: 15363429
references: J Neurosci Methods. 1998 Dec 1;85(2):211-8
references: 9874157
references: J Physiol. 1996 Nov 15;497 ( Pt 1):279-90
references: 8951729
references: Spine J. 2006 Mar-Apr;6(2):138-45
references: 16517384
references: Equine Vet J Suppl. 2010 Nov;(38):695-702
references: 21059083
references: J Manipulative Physiol Ther. 2004 Nov-Dec;27(9):547-53
references: 15614241
references: Ann Intern Med. 1992 Oct 1;117(7):590-8
references: 1388006
references: J Manipulative Physiol Ther. 2005 Nov-Dec;28(9):673-87
references: 16326237
references: J Manipulative Physiol Ther. 1999 Jun;22(5):269-79
references: 10395429
references: Spine J. 2004 Sep-Oct;4(5):574-83
references: 15363431
references: Arch Phys Med Rehabil. 2012 Jan;93(1):56-61
references: 22200384
references: Spine J. 2001 Mar-Apr;1(2):121-30
references: 14588392
references: Spine J. 2007 Sep-Oct;7(5):583-95
references: 17905321
references: J Manipulative Physiol Ther. 1994 Sep;17(7):431-41
references: 7989876
references: J Manipulative Physiol Ther. 2002 Jul-Aug;25(6):353-61
references: 12183693
references: J Manipulative Physiol Ther. 2002 Jan;25(1):34-41
references: 11898016
references: Spine (Phila Pa 1976). 1993 Jul;18(9):1206-12
references: 8362328
references: Spine (Phila Pa 1976). 2000 Oct 1;25(19):2519-24;discussion 2525
references: 11013505
references: JAMA. 1998 Nov 11;280(18):1569-75
references: 9820257
references: Electromyogr Clin Neurophysiol. 2001 Mar;41(2):97-106
references: 11284061
references: Man Ther. 2009 Oct;14(5):531-8
references: 19027342
references: Spine J. 2003 May-Jun;3(3):204-12
references: 14589201
references: Electromyogr Clin Neurophysiol. 1995 Mar;35(2):87-94
references: 7781578
references: J Neurophysiol. 1976 Mar;39(2):324-30
references: 130469
references: Man Ther. 2012 Dec;17(6):577-83
references: 22809745
references: J Manipulative Physiol Ther. 2006 Jan;29(1):22-31
references: 16396726
references: J Electromyogr Kinesiol. 2012 Oct;22(5):670-91
references: 22534288