title: Biodegradable flow-diverting device for the treatment of intracranial aneurysm: short-term results of a rabbit experiment.
abstract: BACKGROUND
  One main complication of a flow-diverting device (FD) in treating intracranial aneurysm is stenosis of parent artery (PA) or occlusion of side branches. The use of a biodegradable device may satisfy the need for aneurysm occlusion and eliminate potential complications.
  
  
  METHODS
  Twenty elastase-induced aneurysm rabbit models were divided into three groups: in group 1 (n = 7), polyglycolic acid FDs (PGA-FDs) were implanted across the necks of aneurysms and the abdominal aortas (AA), covering the ostium of a lumbar artery; in group 2 (n = 7), the PGA-FDs were replaced by metal FDs; and in group 3 (n = 6), the PGA-FDs were only implanted across the necks of aneurysms. Animals in group 3 underwent angiography at 6 weeks; those in groups 1 and 2 underwent angiography at 3 months. The status of aneurysm embolization and patency of side branches were assessed.
  
  
  RESULTS
  Complete aneurysm occlusion rates in groups 1 and 3 were 83.3 and 66.7 %, respectively, compared with 0 % in group 2. No side branch occlusions were noted. PA neointimal hyperplasia was minimal, and there were no significant differences between groups 1 and 2 (P = 0.233). The neointimal coverage ratio of the branch ostium in AA in group 1 was not significantly different from that in group 2 (P = 0.605). The neointima comprised predominantly smooth muscle cells and collagen fibers.
  
  
  CONCLUSIONS
  The PGA-FD was an effective device for the treatment of aneurysms and was safe for side branches at the 3-month follow-up.
authors: Department of Neurosurgery, General Hospital of Jinan Military Command, 25 Shifan Road, Jinan 250031, China.
authors: Kuizhong
authors: K
authors: Wang
authors: Shaoji
authors: S
authors: Yuan
authors: Xuping
authors: X
authors: Zhang
authors: Qiang
authors: Q
authors: Liu
authors: Qisheng
authors: Q
authors: Zhong
authors: Rongwei
authors: R
authors: Zhang
authors: Peigang
authors: P
authors: Lu
authors: Jiwen
authors: J
authors: Li
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001807:Blood Vessel Prosthesis; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D019544:Equipment Failure Analysis; D005260:Female; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000601:surgery*; D008297:Male; D011474:Prosthesis Design; D011817:Rabbits; D011859:Radiography; D015607:Stents; D016896:Treatment Outcome
references: Int J Oral Maxillofac Implants. 1996 Sep-Oct;11(5):667-78
references: 8908867
references: J Thorac Cardiovasc Surg. 2008 Oct;136(4):900-7
references: 18954628
references: J Am Coll Cardiol. 2010 Apr 13;55(15):1553-65
references: 20378071
references: Stroke. 2009 Mar;40(3):952-8
references: 19150864
references: Eur Heart J. 1998 Apr;19(4):601-9
references: 9597409
references: AJNR Am J Neuroradiol. 2009 Oct;30(9):1685-7
references: 19386733
references: Neuroradiology. 2012 Jun;54(6):607-13
references: 21874284
references: Neuroradiology. 2011 Jul;53(7):501-8
references: 20838782
references: Stroke. 2010 Oct;41(10 Suppl):S21-5
references: 20876497
references: Ann Thorac Surg. 2009 Oct;88(4):1269-76
references: 19766820
references: AJNR Am J Neuroradiol. 2009 Jun;30(6):1153-8
references: 19369609
references: Stroke. 2007 Aug;38(8):2346-52
references: 17615366
references: Neurosurgery. 2010 Sep;67(3 Suppl Operative):onsE313-4; discussion onsE314
references: 20679914
references: AJNR Am J Neuroradiol. 2010 Apr;31(4):E43-4
references: 20150311
references: Neuroradiology. 2012 Aug;54(8):849-55
references: 22170078
references: Circulation. 2012 May 15;125(19):2343-53
references: 22508795
references: Circulation. 1998 Jul 21;98(3):224-33
references: 9697822
references: J Biomed Mater Res B Appl Biomater. 2005 Aug;74(2):792-9
references: 15991233
references: Biomaterials. 2010 Nov;31(31):7847-55
references: 20696471
references: Neuroradiology. 2012 Apr;54(4):369-82
references: 21881914
references: Stroke. 2010 Oct;41(10):2247-53
references: 20798369