title: Activities of systemically administered echinocandins against in vivo mature Candida albicans biofilms developed in a rat subcutaneous model.
abstract: This study addresses the effects of micafungin, caspofungin, and anidulafungin against Candida albicans biofilms developed in a subcutaneous catheter rat model system. Doses of 5, 10, and 30 mg/kg (of body weight)/day (the last only for micafungin) were given intravenously for 5, 7, and 10 days. All three echinocandins caused a significant reduction of the Candida cell numbers on the implanted catheters and are thus promising for the treatment of biofilm-related infections.
authors: Department of Molecular Microbiology, VIB, KU Leuven, Leuven, Belgium.
authors: Sona
authors: S
authors: Kucharíková
authors: Nidhi
authors: N
authors: Sharma
authors: Isabel
authors: I
authors: Spriet
authors: Johan
authors: J
authors: Maertens
authors: Patrick
authors: P
authors: Van Dijck
authors: Katrien
authors: K
authors: Lagrou
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D002408:Catheters, Indwelling / Q000382:microbiology; D062109:Dermatologic Surgical Procedures; D054714:Echinocandins / Q000494:pharmacology*; D005260:Female; D007275:Injections, Intravenous; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins
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