title: [Role of glucocorticoids and capsaicin-sensitive neurons in gastroprotective effect of ischemic preconditioning].
abstract: The study was designed to investigate contribution of glucocorticoid hormones and capsaicin-sensitive neurons to gastroprotective effect of ischemic preconditioning against injury induced by 3.5 h gastric ischemia-reperfusion in rats. The contribution of glucocorticoids was investigated by an inhibition of corticosterone synthesis with metyrapone and adrenalectomy followed by corticosterone replacement. To estimate the role of capsaicin-sensitive neurons we used their desensitization. Gastric ischemia was performed by occlusion of celiac artery in anaesthetized rats. In the control animals gastric ischemic preconditioning (0.5 h ischemia-reperfusion) induced plasma corticosterone rise and attenuated gastric injury caused by 3.5 h ischemia-reperfusion. Both adrenalectomy and desensitization of capsaicin-sensitive neurons by itself aggravated ulcerogenic influence of 3.5 h gastric ischemia-reperfusion. However, only adrenalectomy or metyrapone pretreatment, but not desensitization ofcapsaicin-sensitive neurons prevented gastroprotective effect ofischemic preconditioning. The data suggest that glucocorticoids contribute to gastroprotective effect of ischemic preconditioning even in rats with desensitization of capsaicin-sensitive neurons. The findings support participation of capsaicin-sensitive neurons in gastroprotection against injury caused by prolonged ischemia-reperfusion, but not in gastroprotective effect ofischemic preconditioning.
authors: T P
authors: TP
authors: Bagaeva
authors: P Iu
authors: PIu
authors: Bobryshev
authors: O P
authors: OP
authors: Komkova
authors: L P
authors: LP
authors: Filaretova
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D002211:Capsaicin / Q000378:metabolism*; D003345:Corticosterone / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology; D019194:Ischemic Preconditioning; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D015427:Reperfusion Injury / Q000503:physiopathology; D013270:Stomach / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D013276:Stomach Ulcer / Q000378:metabolism / Q000503:physiopathology
chemical_list: D002211:Capsaicin; D003345:Corticosterone; D008797:Metyrapone