title: ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia.
abstract: ZDHHC8 rs175174 polymorphism is located in 22q11.2 region and its role in brain volume has not been fully addressed. A total of 282 schizophrenia patients and 379 controls were genotyped. A sample of 138 patients underwent brain MRI scan. No association was found between schizophrenia and genotypes. Nevertheless, GG-genotype carriers presented gray matter volume (GMV) reduction in frontal lobe compared to A-allele carriers, and cerebellar hemispheres GMV reductions were found in G-allele carriers compared to AA-genotype. Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes.
authors: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo (UNIFESP), Rua Botucatu, 740, Edifício Leitao da Cunha, 1° andar, CEP 04023-900, Sao Paulo, Brazil. vanessakaota@gmail.com
authors: Vanessa K
authors: VK
authors: Ota
authors: Ary
authors: A
authors: Gadelha
authors: Idaiane B
authors: IB
authors: Assunção
authors: Marcos L
authors: ML
authors: Santoro
authors: Denise M
authors: DM
authors: Christofolini
authors: Fernanda T
authors: FT
authors: Bellucco
authors: Airton F
authors: AF
authors: Santos-Filho
authors: Gustavo L
authors: GL
authors: Ottoni
authors: Diogo R
authors: DR
authors: Lara
authors: Jair J
authors: JJ
authors: Mari
authors: Maria I
authors: MI
authors: Melaragno
authors: Marília A C
authors: MA
authors: Smith
authors: Rodrigo A
authors: RA
authors: Bressan
authors: Sintia I
authors: SI
authors: Belangero
authors: Andrea P
authors: AP
authors: Jackowski
mesh_terms: D000217:Acyltransferases / Q000235:genetics*; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*
chemical_list: D008565:Membrane Proteins; D000217:Acyltransferases; C488097:ZDHHC8 protein, human