title: Lipid metabolism greases the stem cell engine.
abstract: Metabolic plasticity is increasingly postulated to be vital in the transition between stemness maintenance and lineage specification. Knobloch et al. (2012) now demonstrate that regulation of lipogenesis by fatty acid synthase and Spot14-dependent malonyl-CoA supply determines the proliferative activity of resident neural stem cells, contributing to adult neurogenesis.
authors: Center for Regenerative Medicine, Mayo Clinic, Rochester, MN 55901, USA.
authors: Clifford D L
authors: CD
authors: Folmes
authors: Sungjo
authors: S
authors: Park
authors: Andre
authors: A
authors: Terzic