title: Genomic instability in pre-neoplastic colonic lesions.
abstract: Genomic instability is a characteristic of most cancers and it is argued that genomic instability is a driving force for tumorigenesis. Data herein demonstrate that genomic instability, as evidenced by microsatellite instability (MSI) and promoter methylation of DNA mismatch repair genes, is common in individual glands of pre-malignant colorectal lesions and raises interesting questions about the role of MSI in the development of colorectal carcinoma.
authors: Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK.
authors: J A
authors: JA
authors: Shaw
authors: T A
authors: TA
authors: Graham
authors: J
authors: J
authors: Stebbing
mesh_terms: D020137:Base Pair Mismatch; D015179:Colorectal Neoplasms / Q000235:genetics*; D019175:DNA Methylation; D004260:DNA Repair / Q000235:genetics; D042822:Genomic Instability; D006801:Humans; D011230:Precancerous Conditions / Q000235:genetics*; D011401:Promoter Regions, Genetic
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