title: The role of interleukin-33 in rhinitis.
abstract: IL-33, a member of the IL-1 cytokine family and a ligand to receptor ST2, has great potential to induce a T helper 2-type inflammatory response. IL-33 is proven to be released by epithelial cells during their injury by different environmental stimuli such as airborne allergens, viruses, and air pollutants. IL-33 acting as an endogenous danger signal is termed an alarmin. As such, this cytokine is considered to play a crucial role in an allergic inflammatory disease such as rhinitis. Recent investigations regarding the IL-33/ST2 axis involvement in Th2 inflammatory response and pathogenesis of rhinitis have been reviewed. The role of IL-33 as a novel promising therapeutic target has also been discussed.
authors: Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, ul. Ceglana 35, Katowice, Poland. b_rogala@pro.onet.pl
authors: Barbara
authors: B
authors: Rogala
authors: Joanna
authors: J
authors: Glück
mesh_terms: D001491:Basophils / Q000276:immunology; D004804:Eosinophils / Q000276:immunology; D006801:Humans; D000067596:Interleukin-33; D007378:Interleukins / Q000502:physiology*; D008407:Mast Cells / Q000276:immunology; D012220:Rhinitis / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology
chemical_list: C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins
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