title: Emerging mechanisms of T-tubule remodelling in heart failure.
abstract: Cardiac excitation-contraction coupling occurs primarily at the sites of transverse (T)-tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the instantaneous excitation and synchronous activation of nearly all Ca(2+) release sites throughout the large ventricular myocyte. Because of the critical roles played by T-tubules and the array of channels and transporters localized to the T-tubule membrane network, T-tubule architecture has recently become an area of considerable research interest in the cardiovascular field. This review will focus on the current knowledge regarding normal T-tubule structure and function in the heart, T-tubule remodelling in the transition from compensated hypertrophy to heart failure, and the impact of T-tubule remodelling on myocyte Ca(2+) handling function. In the last section, we discuss the molecular mechanisms underlying T-tubule remodelling in heart disease.
authors: Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
authors: Ang
authors: A
authors: Guo
authors: Caimei
authors: C
authors: Zhang
authors: Sheng
authors: S
authors: Wei
authors: Biyi
authors: B
authors: Chen
authors: Long-Sheng
authors: LS
authors: Song
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D006332:Cardiomegaly / Q000473:pathology; D056966:Excitation Contraction Coupling; D006333:Heart Failure / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D032383:Myocytes, Cardiac / Q000473:pathology*; D012519:Sarcoplasmic Reticulum / Q000473:pathology* / Q000502:physiology
chemical_list: D002118:Calcium
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