title: [Expression changes of MEK in lung of rats subjected to brain ischemia].
abstract: OBJECTIVE
  To explore the expression changes of mitogen extracellular kinase (MEK) in injured lung after brain ischemia in rats.
  
  
  METHODS
  Adult SD rats were assigned randomly to sham operation group and brain ischemia lung injury (BILI) group. Rats in BILI group were subjected brain ischemia and allowed to survived 3 d. Pathalogical changes in lung were indicated by HE staining. The MEK expression was determined by RT-PCR and Western blot technique.
  
  
  RESULTS
  After brain ischemia, the bulk of inflammatory cells invaded into lung were observed. Upregulated level of MEK mRNA and protein were found at 3 days after ischemia (P<0.05).
  
  
  CONCLUSIONS
  The upregulated expression of MEK implied that the MEK may play some roles in lung injury after brain ischemia.
authors: Department of Respiration, Affiliated Kunhua Hospital of Kunming Science and Technology University, Kunming 650032, China.
authors: Sheng-Lan
authors: SL
authors: Wang
authors: Qi-Qin
authors: QQ
authors: Dan
authors: Rong
authors: R
authors: Rong
authors: Jin-Tao
authors: JT
authors: Li
authors: Yun-Hui
authors: YH
authors: Zhang
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000378:metabolism*; D005260:Female; D008168:Lung / Q000201:enzymology*; D055370:Lung Injury / Q000201:enzymology* / Q000209:etiology; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D012333:RNA, Messenger; D020928:Mitogen-Activated Protein Kinases