title: Stress-enhanced gelation: a dynamic nonlinearity of elasticity.
abstract: A hallmark of biopolymer networks is their sensitivity to stress, reflected by pronounced nonlinear elastic stiffening. Here, we demonstrate a distinct dynamical nonlinearity in biopolymer networks consisting of filamentous actin cross-linked by α-actinin-4. Applied stress delays the onset of relaxation and flow, markedly enhancing gelation and extending the regime of solidlike behavior to much lower frequencies. We show that this macroscopic network response can be accounted for at the single molecule level by the increased binding affinity of the cross-linker under load, characteristic of catch-bond-like behavior.
authors: Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.
authors: Norman Y
authors: NY
authors: Yao
authors: Chase P
authors: CP
authors: Broedersz
authors: Martin
authors: M
authors: Depken
authors: Daniel J
authors: DJ
authors: Becker
authors: Martin R
authors: MR
authors: Pollak
authors: Frederick C
authors: FC
authors: Mackintosh
authors: David A
authors: DA
authors: Weitz
mesh_terms: D000185:Actinin / Q000737:chemistry* / Q000235:genetics; D000199:Actins / Q000737:chemistry*; D004548:Elasticity; D006801:Humans; D008956:Models, Chemical; D017711:Nonlinear Dynamics; D017354:Point Mutation; D013314:Stress, Mechanical; D014783:Viscosity
chemical_list: C111453:ACTN4 protein, human; D000199:Actins; D000185:Actinin
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