title: Melanoma genetic testing, counseling, and adherence to skin cancer prevention and detection behaviors.
abstract: BACKGROUND
  Little is known about the impact of knowledge of CDKN2A and MC1R genotype on melanoma prevention behaviors like sun avoidance and skin examination in the context of familial melanoma.
  
  
  METHODS
  Seventy-three adults with a family history of melanoma were randomly assigned to be offered individualized CDKN2A and MC1R genotyping results in the context of a genetic counseling session, or the standard practice of not being offered counseling or disclosure of genotyping results. Mixed effects or longitudinal logistic models were used to determine whether the intervention affected change in sun protection habits, skin examinations, and perception and beliefs related to melanoma risk, prevention, and genetic counseling.
  
  
  RESULTS
  All participants in the intervention group who attended genetic counseling sessions chose to receive their test results. From baseline to follow-up, participants in the intervention group reported an increase in the frequency of skin self-examinations compared with a slight decrease in the control group (P = 0.002). Participants in the intervention group reported a smaller decrease in frequency of wearing a shirt with long sleeves than did participants in the control group (P = 0.047). No effect of the intervention was noted for other outcomes.
  
  
  CONCLUSIONS
  Feedback of CDKN2A and MC1R genotype among families without known pathogenic CDKN2A mutations does not seem to decrease sun protection behaviors.
  
  
  CONCLUSIONS
  While disclosure of CDKN2A and MC1R genotype did not have negative effects on prevention, the benefits of communicating this information remain unclear. The small number of families who tested positive for CDKN2A mutations in this study is a limitation.
authors: Perelman School of Medicine and School of Nursing, University of Pennsylvania, 801 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA. kglanz@upenn.edu
authors: Karen
authors: K
authors: Glanz
authors: Kathryn
authors: K
authors: Volpicelli
authors: Peter A
authors: PA
authors: Kanetsky
authors: Michael E
authors: ME
authors: Ming
authors: Lynn M
authors: LM
authors: Schuchter
authors: Christopher
authors: C
authors: Jepson
authors: Susan M
authors: SM
authors: Domchek
authors: Katrina
authors: K
authors: Armstrong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008545:Melanoma / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010349:Patient Compliance; D011379:Prognosis; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D013472:Sunlight / Q000009:adverse effects*
chemical_list: D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16; D044102:Receptor, Melanocortin, Type 1
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