title: Early occurrence of cerebral white matter abnormality detected in a neonate with salt-wasting congenital adrenal hyperplasia.
abstract: The development of white matter signal abnormalities on magnetic resonance brain imaging (MRI) in children and young adults with congenital adrenal hyperplasia has been well documented. Existing theories regarding the development of these findings include effects of electrolyte imbalances, effects of disease-related hormone abnormalities, and non-physiologic long-term administration of corticosteroids. Many of the patients previously described were normal neurologically. We describe the case of white matter signal abnormalities in a neonate with salt-wasting congenital adrenal hyperplasia who presented with seizures during the first week of life, possibly due to a transient blood calcium disturbance. This case suggests that white matter changes are not simply the result of chronic insults and that they may not always be subclinical.
authors: Department of Radiology, Bellevue Hospital Center, New York, NY, USA. mattwinfeld@gmail.com
authors: Matthew
authors: M
authors: Winfeld
authors: Payal
authors: P
authors: Patel
authors: Bina
authors: B
authors: Shah
authors: Ruth
authors: R
authors: Nass
authors: Sarah
authors: S
authors: Milla
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D017668:Age of Onset; D001921:Brain / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000473:pathology; D042241:Early Diagnosis; D006801:Humans; D007231:Infant, Newborn; D056784:Leukoencephalopathies / Q000151:congenital / Q000000981:diagnostic imaging / Q000209:etiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011859:Radiography; D014463:Ultrasonography