title: Rabbit model of radiation-induced lung injury.
abstract: OBJECTIVE
  To explore the feasibility of establishing an animal model of chronic radiation-induced lung injury.
  
  
  METHODS
  Twenty-eight New Zealand white rabbits were randomly divided into 3 groups (the right lung irradiation group, the whole lung irradiation group and the control group). Animal model of radiation-induced lung injury was established by high-does radiotherapy in the irradiation groups, then all rabbits underwent CT and pathological examinations at 1, 2, 4, 8, 12, 16 weeks, respectively after radiation.
  
  
  RESULTS
  Within 4 weeks of irradiation, some rabbits in the right lung irradiation group and whole lung irradiation group died. CT and pathological examinations all showed acute radiation pneumonitis. At 8-12 weeks after irradiation, CT scanning showed ground glass samples signs, patchy shadows and fibrotic stripes. Pathological examination showed the fibrosis pulmonary alveolar wall thickened obviously.
  
  
  CONCLUSIONS
  The clinical animal model of chronic radiation-induced lung injury which corresponds to practical conditions in clinic can be successfully established.
authors: Cardio-Thoracic Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi, China.
authors: Zhen-Zong
authors: ZZ
authors: Du
authors: Hua
authors: H
authors: Ren
authors: Jian-Fei
authors: JF
authors: Song
authors: Li-Fei
authors: LF
authors: Zhang
authors: Feng
authors: F
authors: Lin
authors: Hai-Yong
authors: HY
authors: Wang
mesh_terms: D000818:Animals; D005240:Feasibility Studies; D011650:Pulmonary Alveoli / Q000473:pathology*; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000000981:diagnostic imaging / Q000473:pathology*; D017564:Radiation Pneumonitis / Q000000981:diagnostic imaging / Q000473:pathology*; D013997:Time Factors; D014057:Tomography, X-Ray Computed