title: Association between GSTM1 polymorphism and DNA adduct concentration in the occupational workers exposed to PAHs: a meta-analysis.
abstract: Increasing investigations have been conducted on the association between DNA adducts and glutathione S-transferase Mu 1 (GSTM1) null genotype in occupationally exposed population. However, the results were controversial. The objective of the present study was to perform a meta-analysis to better understand the possible association between DNA adduct levels and GSTM1 genotype in occupational exposure population. Among a total of 167 literature searched from frequently-used databases, 7 articles corresponding to the specific criteria were enrolled into the meta-analysis. There was a significant increase of DNA adduct levels in occupationally exposed workers compared with control groups (p=0.003). Additionally, DNA adduct levels among the carriers of null GSTM1 were significantly higher than those of active GSTM1 carriers in exposure workers (p=0.017). Egger's test (p=0.056) and Begg's test (p=0.368) indicated that there was no evidence of publication bias. In conclusion, workers exposed to polycyclic aromatic hydrocarbons (PAHs) were at high risk to form DNA adducts, and the occupationally exposed workers who carried null GSTM1 were more susceptible to damage from PAHs.
authors: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China; Department of Occupational and Environmental Health, Hangzhou, Zhejiang, 310058, China.
authors: Min
authors: M
authors: Liu
authors: Lihua
authors: L
authors: Chen
authors: Rongrong
authors: R
authors: Zhou
authors: Jian
authors: J
authors: Wang
mesh_terms: D018736:DNA Adducts / Q000187:drug effects* / Q000378:metabolism; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D016273:Occupational Exposure / Q000032:analysis*; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D011110:Polymorphism, Genetic
chemical_list: D018736:DNA Adducts; D005982:Glutathione Transferase; D011084:Polycyclic Aromatic Hydrocarbons