title: Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.
abstract: OBJECTIVE
  To investigate the efficacy of hydrogen-rich water for the treatment of patients with interstitial cystitis/painful bladder syndrome (IC/PBS).
  
  
  METHODS
  We conducted a prospective, randomized, double-blind, placebo-controlled clinical trial of hydrogen-rich water in patients with IC/PBS. Inclusion criteria were stable symptoms of IC/PBS for ≥ 12 weeks after bladder hydrodistension, Interstitial Cystitis Symptom Index score of ≥ 7 and bladder pain (question 4 on Interstitial Cystitis Symptom Index) of ≥ 4. They were randomized by a 2:1 ratio to receive hydrogen-rich water or placebo water for 8 weeks. The symptoms were assessed using the Interstitial Cystitis Symptom Index, Interstitial Cystitis Problem Index, Parsons' Pelvic Pain and Urgency/Frequency Patient Symptom Scale, visual analog scale bladder pain scores, and a standard 3-day voiding diary. The primary outcome was improvement of patient-reported symptoms evaluated after treatment.
  
  
  RESULTS
  A total of 30 participants (29 women and 1 man, age 64.0 ± 14.8 years) were enrolled in the present study, and 2 patients (both women) were withdrawn from the study. The score of bladder pain was significantly reduced in both groups. However, the effect of hydrogen-rich water on symptoms was not significantly different from that of placebo, although supplementation with hydrogen-rich water was extremely effective in improving the bladder pain score in 11% of the patients.
  
  
  CONCLUSIONS
  The results of the present study do not support the use of supplementation with hydrogen-rich water for treating patients with IC/PBS.
authors: Department of Renal and Urologic Surgery, Asahikawa Medical University, Hokkaido, Japan. matsums@asahikawa-med.ac.jp
authors: Seiji
authors: S
authors: Matsumoto
authors: Tomohiro
authors: T
authors: Ueda
authors: Hidehiro
authors: H
authors: Kakizaki
mesh_terms: D000368:Aged; D018856:Cystitis, Interstitial / Q000188:drug therapy*; D004311:Double-Blind Method; D060766:Drinking Water / Q000008:administration & dosage / Q000737:chemistry*; D005260:Female; D006801:Humans; D006859:Hydrogen / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D012720:Severity of Illness Index
chemical_list: D060766:Drinking Water; D006859:Hydrogen