title: [The role of feeding behaviour hormones in the development of cholelithiasis].
abstract: THE PURPOSE. To analyze the possible association between gallstone disease (GSD), and some adipokine: leptin, adiponectin, ghrelin, resistin, kaheksin (TNFalpha), visfatin. RECENT EVIDENCE IN THE LITERATURE. The prevalence of GSD increases by a factor not so much with age (in women - 6.0%, 7.9%, 8.5% and 18.6%, respectively, four age decade from 25 to 64 years - according to the epidemiological study in the frame of the WHO "Monica" in Novosibirsk in 1994-1995 years), but with metabolic disorders: GSD diagnosed in 17.6% in diabetes mellitus, in obesity III-IV degree - up to 100%. Leptin regulates the expression of genes responsible for the pathogenesis of cholesterol GSD -cholecystokinin receptor gene A, acetylcholine receptor beta2, Ca-calmodulin-dependent protein kinase, mucin3, carboxylesterazy, HMG-CoA reductase. Was found negative correlation of GSD with adiponectin levels and positive - with visfatin levels. Elevated ghrelin levels performs protective role to GSD (OR = 0,27, p = 0,02). In the analysis of GSD-associated regions on chromosome 1 p, genes TNFR2 receptor and TNFRSF1B included in a number of positional candidate genes.
authors: I N
authors: IN
authors: Grigor'eva
authors: A Iu
authors: AIu
authors: Iamlikhanova
mesh_terms: D054392:Adipokines / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002769:Cholelithiasis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D012800:Siberia / Q000453:epidemiology
chemical_list: D054392:Adipokines