title: MMP-9 (-1562 C:T) polymorphism as a biomarker of susceptibility to severe pre-eclampsia.
abstract: OBJECTIVE
  To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia.
  
  
  METHODS
  MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women.
  
  
  RESULTS
  A significantly higher frequency of MMP-9 CT genotype was observed in both mild and severe pre-eclamptic women compared with controls. In the presence of CT + TT genotype the risk of severe pre-eclampsia increased 2.37-fold (p = 0.02). In women with early-onset pre-eclampsia the frequency of MMP-9 CT + TT genotype was significantly higher (p = 0.045) compared with those with late-onset pre-eclampsia.
  
  
  CONCLUSIONS
  The MMP-9 variant could be a useful biomarker of susceptibility to severe pre-eclampsia and early-onset severe pre-eclampsia.
authors: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. zrahimi@kums.ac.ir
authors: Zohreh
authors: Z
authors: Rahimi
authors: Ziba
authors: Z
authors: Rahimi
authors: Maria Omidi
authors: MO
authors: Shahsavandi
authors: Kazem
authors: K
authors: Bidoki
authors: Mansour
authors: M
authors: Rezaei
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D014280:Triglycerides; D008315:Malondialdehyde; D020780:Matrix Metalloproteinase 9