title: Nutritional composition analysis of meat from human lactoferrin transgenic bulls.
abstract: Transgenic technology has many potential advantages in food production. However, the transgenic technology process may influence the composition of food products derived from genetically engineered (GE) animals, which may be adverse to human health. Therefore, it is very important to research the compositions of GE animal products. Here, we analyzed the compositions of meat from the offspring of human lactoferrin (hLF) transgenic cows, which can express human lactoferrin proteins in their mammary gland. Six hLF transgenic bulls and three wide-type (WT) bulls, 10 months of age, were slaughtered for meat composition analysis. To determine the comparative health of hLF bulls for meat analysis, hematological analyses, organ/body weight analyses and pathology analyses were conducted. Results of the meat analysis show that there were no significant differences in the hematological parameters, organ/body weight ratios of hLF and WT bulls (P>0.05), and histopathological examination of the main organs of hLF bulls revealed no abnormalities. Nutrient parameters of meat compositions of hLF and WT bulls did not show any significant differences (P>0.05). All of these results suggest that the hLF transgene did not have an impact on the meat nutrient compositions of hLF bulls.
authors: State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, PR China.
authors: Jie
authors: J
authors: Zhao
authors: Jianxiang
authors: J
authors: Xu
authors: Jianwu
authors: J
authors: Wang
authors: Ning
authors: N
authors: Li
mesh_terms: D000596:Amino Acids / Q000032:analysis / Q000378:metabolism; D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics* / Q000378:metabolism; D002417:Cattle / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D005223:Fats / Q000032:analysis / Q000378:metabolism; D059022:Food Safety; D006801:Humans; D007781:Lactoferrin / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008460:Meat / Q000032:analysis*; D008903:Minerals / Q000032:analysis / Q000378:metabolism; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism; D009929:Organ Size; D014815:Vitamins / Q000032:analysis / Q000378:metabolism
chemical_list: D000596:Amino Acids; D005223:Fats; D008903:Minerals; D014815:Vitamins; D007781:Lactoferrin