title: Inflammatory acne management with a novel prescription dietary supplement.
abstract: BACKGROUND
  Inflammatory acne, particularly in post-adolescent women, is increasing in incidence. The most effective therapeutic modality for treatment of this type of acne has been the administration of oral tetracyclines. Long-term acne treatment with such drugs, however, is frequently accompanied by undesirable adverse reactions, including gastrointestinal disturbances, antianabolic effects, headaches, tinnitus, and photosensitivity.
  
  
  OBJECTIVE
  To assess the usefulness of a novel dietary supplement in the overall management of patients with inflammatory acne vulgaris.
  
  
  METHODS
  235 patients with inflammatory acne vulgaris were enrolled by dermatologists in a multicenter, open-label, 8-week, prospective study evaluating the effects of adding NicAzel, 1 to 4 tablets daily, to their current acne treatment regimen.
  
  
  RESULTS
  A statistically significant (P<.0001) number of patients demonstrated improvement over their previous acne treatment regimens after both 4 and 8 weeks of NicAzel (nicotinamide, azelaic acid, zinc, pyridoxine, copper, folic acid; Elorac Inc, Vernon Hills, IL) use. At week 8, 88% of the patients experienced a visible reduction in inflammatory lesions, and 81% of the patients rated their appearance as much or moderately better compared with baseline. Three-quarters (76%) of the patients thought NicAzel was at least as effective as previous treatment with oral antibiotics.
  
  
  CONCLUSIONS
  Patients with inflammatory acne showed significant improvement in acne severity and overall appearance when NicAzel was added to their existing treatment regimen.
authors: Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors: Alan R
authors: AR
authors: Shalita
authors: Ronald
authors: R
authors: Falcon
authors: Alan
authors: A
authors: Olansky
authors: Patricia
authors: P
authors: Iannotta
authors: Arash
authors: A
authors: Akhavan
authors: Doris
authors: D
authors: Day
authors: Anthony
authors: A
authors: Janiga
authors: Prashant
authors: P
authors: Singri
authors: John E
authors: JE
authors: Kallal
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D003300:Copper / Q000009:adverse effects / Q000627:therapeutic use*; D003998:Dicarboxylic Acids / Q000009:adverse effects / Q000627:therapeutic use*; D019587:Dietary Supplements / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D005492:Folic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000009:adverse effects / Q000627:therapeutic use*; D017060:Patient Satisfaction; D055553:Prescription Drugs; D011446:Prospective Studies; D011736:Pyridoxine / Q000009:adverse effects / Q000627:therapeutic use*; D013754:Tetracyclines / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult; D015032:Zinc / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D003998:Dicarboxylic Acids; D055553:Prescription Drugs; D013754:Tetracyclines; D009536:Niacinamide; D003300:Copper; D005492:Folic Acid; C010038:azelaic acid; D015032:Zinc; D011736:Pyridoxine