title: Evaluation of Total Antioxidant Capacity of Saliva in Type 2 Diabetic Patients with and without Periodontal Disease: A Case-Control Study.
abstract: BACKGROUND
  Diabetes mellitus (DM) has been linked with oxidative stress and decreased antioxidant defense. A connection has been established between diabetes and periodontal disease.
  
  
  OBJECTIVE
  The aim of present study was to compare salivary total antioxidant capacity of type 2 DM patients and healthy subjects with and without periodontal disease.
  
  
  METHODS
  A total of 120 subjects consisting of 30 type 2 DM patients with periodontal disease; 30 type 2 DM patients without periodontal disease; 30 healthy subjects with periodontal disease; 30 healthy subjects without periodontal disease were included in the study. After clinical measurement and samplings, total antioxidant capacity in saliva of type 2 diabetic and healthy subjects were determined, and the data were tested by non-parametric tests. Total antioxidant capacity of the clinical samples was determined spectrophotometrically.
  
  
  RESULTS
  The mean salivary total antioxidant capacity was lowest in diabetic patients with periodontitis.
  
  
  CONCLUSIONS
  Total antioxidant capacity is inversely proportional to the severity of inflammation and can be used as an useful marker of periodontitis in healthy and diabetic patients.
authors: Department of Periodontics, Rural Dental College, Loni, Karnataka, India.
authors: Gowri
authors: G
authors: Pendyala
authors: Biju
authors: B
authors: Thomas
authors: Saurabh R
authors: SR
authors: Joshi
keywords: Antioxidants; Diabetes mellitus; Free radicals; Periodontitis; Total antioxidant capacity
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