title: [Expressions and clinical significance of vasculogenic mimicry and related protein Mig-7 and MMP-2 in gastric carcinoma].
abstract: OBJECTIVE
  To study the expressions and clinical significance of vasculogenic mimicry (VM) and the related protein Mig-7 and MMP-2 in gastric carcinoma.
  
  
  METHODS
  We observed the expressions of CD34, Mig-7 and MMP-2 in 110 patients with gastric carcinoma using immunohistochemistry, VM was determined by CD34/PAS double staining, and analyzed their correlations with the clinical and pathological characteristics of the patients.
  
  
  RESULTS
  In the 110 patients with gastric carcinoma, 35(31.82%) were found positive for VM expression, and it was correlated with the pathological degree and lymph node metastasis (P<0.05), that was, the positive rate of VM in the poorly-differentiated tissues (34%) was higher than that in the well-differentiated tissues (10%), and it was also higher in the lymph node metastasis than that in the non-lymph node metastasis. The expression of Mig-7 was found in 104 out of the 110 cases of gastric carcinoma, with a positive rate of 94.54%. The high expression of Mig-7 was related to lymph node metastasis (P<0.05). The expression rates of Mig-7 and MMP-2 were higher in the VM-positive group than in the VM-negative group (P<0.05). The average survival time and median survival time of the VM-positive group were shorter than those of the VM-negative group (P<0.05).
  
  
  CONCLUSIONS
  The presence of VM in gastric carcinoma tissues is proved. The high expressions of Mig-7 and MMP-2 in gastric carcinoma tissues may have a synergistic promoting effect on VM formation. VM is closely associated with the invasion, metastasis and poor prognosis of gastric carcinoma.
authors: Department of Gastroenterology, Chongqing Medical University, Chongqing, China.
authors: Shiping
authors: S
authors: Liao
authors: Qing
authors: Q
authors: Gao
mesh_terms: D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D018716:Molecular Mimicry; D009363:Neoplasm Proteins / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*
chemical_list: D009363:Neoplasm Proteins; C482285:TOX4 protein, human; D020778:Matrix Metalloproteinase 2