title: The impact of HLA-E polymorphisms on relapse following allogeneic hematopoietic stem cell transplantation.
abstract: Since relapse following allogeneic hematopoietic stem cell transplantation (HSCT) can be due to the escape of the residual malignant cells from the graft-versus-leukemia (GvL) effect and given the role of NK cells in GvL and the importance of HLA-E in the modulation of NK cell function, we investigated whether polymorphisms of HLA-E molecule could impact on the incidence of relapse and the improvement of Disease-free Survival (DFS) after allogeneic HSCT. The study group included 56 pairs of donors and patients with malignant hematological disorders undergoing HLA-E matched allogeneic HSCT. The median follow-up was 43.6 (range 20.5-113.1) months. They were genotyped for HLA-E locus using a sequence-specific primer (SSP)-PCR. We found a lower incidence of relapse (p=0.02) in the patients with HLA-E*0103/0103 genotype compared to those with other genotypes of HLA-E. We also showed an association between HLA-E*0103/0103 genotype and a better DFS (p=0.001). Our results suggest a protective role for HLA-E*0103/0103 genotype against relapse and an association between this genotype and an improved DFS following HLA-E matched allogeneic HSCT.
authors: Malignant Hematology and Stem Cell Transplantation Service, Alfred Hospital, Monash University, Melbourne, Australia.
authors: Ehteramolsadat
authors: E
authors: Hosseini
authors: Anthony P
authors: AP
authors: Schwarer
authors: Arash
authors: A
authors: Jalali
authors: Mehran
authors: M
authors: Ghasemzadeh
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D060005:Genotyping Techniques; D020544:Graft vs Leukemia Effect / Q000235:genetics / Q000276:immunology; D019337:Hematologic Neoplasms / Q000235:genetics / Q000276:immunology / Q000401:mortality / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015996:Survival Rate; D014019:Tissue Donors; D014184:Transplantation, Homologous; D000097625:HLA-E Antigens
chemical_list: D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens