title: Intracellular responses to frequency modulated tones in the dorsal cortex of the mouse inferior colliculus.
abstract: Frequency modulations occur in many natural sounds, including vocalizations. The neuronal response to frequency modulated (FM) stimuli has been studied extensively in different brain areas, with an emphasis on the auditory cortex and the central nucleus of the inferior colliculus. Here, we measured the responses to FM sweeps in whole-cell recordings from neurons in the dorsal cortex of the mouse inferior colliculus. Both up- and downward logarithmic FM sweeps were presented at two different speeds to both the ipsi- and the contralateral ear. Based on the number of action potentials that were fired, between 10 and 24% of cells were selective for rate or direction of the FM sweeps. A somewhat lower percentage of cells, 6-21%, showed selectivity based on EPSP size. To study the mechanisms underlying the generation of FM selectivity, we compared FM responses with responses to simple tones in the same cells. We found that if pairs of neurons responded in a similar way to simple tones, they generally also responded in a similar way to FM sweeps. Further evidence that FM selectivity can be generated within the dorsal cortex was obtained by reconstructing FM sweeps from the response to simple tones using three different models. In about half of the direction selective neurons the selectivity was generated by spectrally asymmetric synaptic inhibition. In addition, evidence for direction selectivity based on the timing of excitatory responses was also obtained in some cells. No clear evidence for the local generation of rate selectivity was obtained. We conclude that FM direction selectivity can be generated within the dorsal cortex of the mouse inferior colliculus by multiple mechanisms.
authors: Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam Rotterdam, Netherlands.
authors: H-Rüdiger A P
authors: HR
authors: Geis
authors: J Gerard G
authors: JG
authors: Borst
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D000818:Animals; D001303:Auditory Cortex / Q000166:cytology / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D007245:Inferior Colliculi / Q000166:cytology / Q000502:physiology*; D007425:Intracellular Membranes / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D055366:Synaptic Potentials / Q000502:physiology
keywords: FM reconstruction; auditory midbrain; direction selectivity; patch-clamp; rate selectivity
references: Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2293-8
references: 15677723
references: J Comp Neurol. 2000 Oct 16;426(2):165-81
references: 10982461
references: J Neurosci. 2009 Apr 29;29(17):5483-93
references: 19403816
references: Eur J Neurosci. 2011 Jan;33(2):251-8
references: 21198978
references: J Neurosci. 2008 Sep 24;28(39):9806-16
references: 18815265
references: J Neurophysiol. 2009 Apr;101(4):2017-29
references: 19211659
references: Hear Res. 1996 Sep 1;98(1-2):137-51
references: 8880188
references: PLoS Biol. 2005 Dec;3(12):e386
references: 16248680
references: Nat Methods. 2008 Jan;5(1):61-7
references: 18157136
references: Exp Brain Res. 1992;91(1):94-104
references: 1301377
references: J Neurophysiol. 2011 Nov;106(5):2399-414
references: 21813749
references: Nature. 2003 Jul 10;424(6945):201-5
references: 12853959
references: J Neurophysiol. 1968 Jul;31(4):537-48
references: 5709870
references: J Neurosci. 2007 May 2;27(18):4882-93
references: 17475796
references: Exp Neurol. 1974 Mar;42(3):532-40
references: 4828674
references: J Neurophysiol. 2007 Feb;97(2):1368-78
references: 17135472
references: J Neurosci. 2010 Feb 3;30(5):1861-8
references: 20130195
references: Eur J Neurosci. 2003 Oct;18(8):2301-12
references: 14622191
references: J Neurophysiol. 1976 Jan;39(1):179-94
references: 1249601
references: J Acoust Soc Am. 1973 Jul;54(1):174-90
references: 4731643
references: J Neurophysiol. 1994 Sep;72(3):1061-79
references: 7807196
references: Exp Brain Res. 1991;83(3):598-606
references: 2026200
references: J Neurophysiol. 2009 Apr;101(4):2002-16
references: 19193772
references: J Neurosci. 2011 Nov 16;31(46):16529-40
references: 22090479
references: J Neurophysiol. 1965 Jul;28:655-72
references: 14347626
references: J Neurophysiol. 2010 Sep;104(3):1456-71
references: 20631213
references: J Neurosci. 2009 Oct 14;29(41):13030-41
references: 19828816
references: Front Neural Circuits. 2012 Aug 17;6:54
references: 22912604
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011 May;197(5):615-23
references: 20596868
references: Biol Lett. 2009 Oct 23;5(5):593-6
references: 19535367
references: J Physiol. 1965 Jul;179(1):26-53
references: 5854378
references: J Comp Neurol. 2013 Jan 1;521(1):189-202
references: 22700282
references: J Physiol. 2011 Aug 15;589(Pt 16):3955-67
references: 21727222
references: Exp Brain Res. 2003 Dec;153(4):550-3
references: 12961056
references: J Acoust Soc Am. 1994 Sep;96(3):1229-54
references: 7962992
references: J Neurophysiol. 2006 Sep;96(3):1320-36
references: 16790604
references: J Comp Physiol A. 1997 Dec;181(6):559-71
references: 9449817
references: Exp Brain Res. 1985;58(3):443-54
references: 4007088
references: Hear Res. 2011 Apr;274(1-2):27-39
references: 20685288
references: Hear Res. 1998 Aug;122(1-2):97-108
references: 9714578
references: Neuron. 2012 Mar 8;73(5):1016-27
references: 22405210
references: J Neurophysiol. 2011 Nov;106(5):2523-35
references: 21775712