title: Activity of daptomycin with or without 25 percent ethanol compared to combinations of minocycline, EDTA, and 25 percent ethanol against methicillin-resistant Staphylococcus aureus isolates embedded in biofilm.
abstract: Central venous catheters commonly develop central line-associated bloodstream infections. In vitro antibiotic lock therapy (ALT) was simulated on 10 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates imbedded in biofilm-coated silicon disks. Five days of 4-h daily exposures to daptomycin (2.5 mg/ml) in 25% ethanol or minocycline (3 mg/ml) plus 25% ethanol and 30 mg/ml EDTA resulted in significantly greater elimination of MRSA colonization than treatment with minocycline alone.
authors: Department of Medicine/Infectious Disease, University of Chicago, Chicago, Illinois, USA.
authors: R
authors: R
authors: Estes
authors: J
authors: J
authors: Theusch
authors: A
authors: A
authors: Beck
authors: D
authors: D
authors: Pitrak
authors: Kathleen M
authors: KM
authors: Mullane
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D017576:Daptomycin / Q000494:pharmacology*; D004338:Drug Combinations; D004492:Edetic Acid / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008911:Minocycline / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D000431:Ethanol; D004492:Edetic Acid; D008911:Minocycline; D017576:Daptomycin
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