title: Targeting chromatin readers.
abstract: Modulation of gene expression through epigenetic signaling has recently emerged as a novel approach in treating human disease. Specifically, chromatin reader proteins, which mediate protein-protein interactions via binding to modified lysine residues, are gaining traction as potential therapeutic targets. Herein, we review recent efforts to understand and modulate the activity of chromatin reader proteins with small-molecule ligands.
authors: Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors: L I
authors: LI
authors: James
authors: S V
authors: SV
authors: Frye
mesh_terms: D002843:Chromatin / Q000187:drug effects* / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000187:drug effects*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D054730:Protein Interaction Domains and Motifs / Q000187:drug effects*
chemical_list: D002843:Chromatin
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