title: Chemotherapy-associated tongue hyperpigmentation and blue lunula.
abstract: Combination chemotherapy is associated with cutaneous and mucosal side effects. Antineoplastic agents have been associated with mucosal and nail pigmentation. We describe a 16-year-old Saudi Arabian girl with combination chemotherapy-associated black tongue hyperpigmentation and blue lunula. The diagnosis of drug-associated pigmentary changes is based on correlating the onset of the clinical observations with the temporal initiation of the patient's chemotherapy agents. Spontaneous fading of antineoplastic therapy-induced tongue or nail dyschromia may subsequently occur following discontinuation of the causative drug.
authors: Department of Dermatology, The University of Texas Medical School at Houston, Houston, TX, USA.
authors: Kathleen M
authors: KM
authors: Casamiquela
authors: Philip R
authors: PR
authors: Cohen
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D009260:Nail Diseases / Q000139:chemically induced / Q000188:drug therapy*; D018242:Neuroectodermal Tumors, Primitive / Q000150:complications / Q000188:drug therapy; D013125:Spinal Neoplasms / Q000150:complications / Q000188:drug therapy; D014060:Tongue Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology