title: A multicenter retrospective analysis of the clinical features of pernicious anemia in a Korean population.
abstract: To determine the approximate incidence and clinical features of pernicious anemia in a Korean population, we retrospectively analyzed clinical data for patients with pernicious anemia who were diagnosed between 1995 and 2010 at five hospitals in Chungnam province. Ninety-seven patients were enrolled, who accounted for 24% of patients with vitamin B(12) deficiency anemia. The approximate annual incidence of pernicious anemia was 0.3 per 100,000. The median age was 66 (range, 32-98) yr, and the male/female ratio was 1.25. Anemia-associated discomfort was the most common symptom (79.4%), followed by gastrointestinal and neurological symptoms (78.4% and 38.1%, respectively). Pancytopenia was found in 36 patients (37.1%), and autoimmune disorders were found in 15 patients (15.5%). Antibody to intrinsic factor was detected in 62 (77.5%) of 80 patients examined, and antibody to parietal cells was detected in 35 (43.2%) of 81 patients examined. Of the 34 patients who underwent tests for Helicobacter pylori, 7 (12.5%) were positive. The anemia-associated and gastrointestinal symptoms resolved completely in all patients after intramuscular injection of cobalamin, whereas neurological symptoms remained in some. In conclusion, pernicious anemia is less frequent in Koreans than in Western populations; however, the clinical features of this disorder in Koreans do not differ from those of Western cases.
authors: Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea.
authors: Ik-Chan
authors: IC
authors: Song
authors: Hyo Jin
authors: HJ
authors: Lee
authors: Han-Jo
authors: HJ
authors: Kim
authors: Sang-Byung
authors: SB
authors: Bae
authors: Kyu-Taek
authors: KT
authors: Lee
authors: Young-Jun
authors: YJ
authors: Yang
authors: Suk-Young
authors: SY
authors: Park
authors: Do-Yeun
authors: DY
authors: Cho
authors: Nae Yu
authors: NY
authors: Kim
authors: In-Sung
authors: IS
authors: Cho
authors: Deog-Yeon
authors: DY
authors: Jo
mesh_terms: D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D044466:Asian People; D001327:Autoimmune Diseases / Q000150:complications / Q000453:epidemiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D016481:Helicobacter Infections / Q000175:diagnosis; D016480:Helicobacter pylori; D006801:Humans; D007518:Isoantibodies / Q000097:blood; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000150:complications / Q000453:epidemiology; D010295:Parietal Cells, Gastric / Q000276:immunology; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D014805:Vitamin B 12 / Q000097:blood / Q000627:therapeutic use
chemical_list: D007518:Isoantibodies; D014805:Vitamin B 12
keywords: Anemia, Pernicious; Anti-Intrinsic Factor Antibody; Anti-Parietal Cell Antibody; Helicobacter Pylori; Vitamin B
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