title: CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells.
abstract: We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.
authors: Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, Republic of Korea.
authors: Jungmin
authors: J
authors: Park
authors: Minhee
authors: M
authors: Ku
authors: Eunjung
authors: E
authors: Kim
authors: Yeonji
authors: Y
authors: Park
authors: Yoochan
authors: Y
authors: Hong
authors: Seungjoo
authors: S
authors: Haam
authors: Jae-Ho
authors: JH
authors: Cheong
authors: Eun Sung
authors: ES
authors: Park
authors: Jin-Suck
authors: JS
authors: Suh
authors: Yong-Min
authors: YM
authors: Huh
authors: Jaemoon
authors: J
authors: Yang
mesh_terms: D000818:Animals; D002232:Carbocyanines; D045744:Cell Line, Tumor; D058948:Cell Tracking / Q000379:methods; D005456:Fluorescent Dyes; D018960:Hyaluronan Receptors / Q000378:metabolism*; D020100:Hydrogels / Q000138:chemical synthesis; D046911:Macromolecular Substances; D051379:Mice; D008807:Mice, Inbred BALB C; D008856:Microscopy, Fluorescence / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology*; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: C098793:CY5.5 cyanine dye; D002232:Carbocyanines; D005456:Fluorescent Dyes; D018960:Hyaluronan Receptors; D020100:Hydrogels; D046911:Macromolecular Substances