title: Chronic Exercise Training Down-Regulates TNF-α and Atrogin-1/MAFbx in Mouse Gastrocnemius Muscle Atrophy Induced by Hindlimb Unloading.
abstract: The purpose of this study was to investigate the effect of chronic moderate-intensity training in order to prevent muscle atrophy with a focus on TNF-α and atrogin-1/MAFbx as main proteolytic indicators. Hindlimb unloading model of mice received treadmill running exercise for 1 hr per day during hindlimb unloading period of 6 weeks. The gastrocnemius muscle mass, muscle fiber cross-sectional area, and succinate dehydrogenase (SDH) activity in the muscle fiber were higher in the exercised group, while TNF-α and atrogin-1/MAFbx mRNA expressions were significantly lower. Results in the present study showed that chronic exercise could prevent over expression of TNF-α and atrogin-1/MAFbx in the atrophied skeletal muscle, providing further support to the effects of chronic exercise training on muscle atrophy.
authors: Department of Rehabilitation Science, Kobe University, Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142, Japan.
authors: Saad
authors: S
authors: Al-Nassan
authors: Naoto
authors: N
authors: Fujita
authors: Hiroyo
authors: H
authors: Kondo
authors: Shinichiro
authors: S
authors: Murakami
authors: Hidemi
authors: H
authors: Fujino
keywords: TNF-α; atrogin-1/MAFbx; gastrocnemius; muscle atrophy
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