title: Chronic dietary choline supplementation modulates attentional change in adult rats.
abstract: In two experiments adult rats were maintained on a diet enriched with added choline for 12 weeks prior to behavioral testing; control rats remained on the standard diet during this time. In Experiment 1 all rats received training in the Hall-Pearce negative transfer paradigm in which prior training with a conditioned stimulus (CS) paired with a small reinforcer retards further learning when the size of the reinforcer is increased. This effect, which has been attributed to a loss of associability by the CS, was obtained in control subjects but not in those given the supplement. Experiment 2 investigated the effect of prior nonreinforced exposure of the to-be-CS (latent inhibition). Such exposure retarded subsequent learning in control subjects, but latent inhibition was not obtained in those given the supplement. We conclude that the mechanism that reduces the attention paid to a stimulus that accurately predicts its consequences does not operate effectively after choline supplementation. These results are consistent with a role for the cholinergic system of the basal forebrain in modulation of attention.
authors: University of Granada, Granada, Spain. hmoreno@correo.ugr.es
authors: Hayarelis
authors: H
authors: Moreno
authors: Isabel
authors: I
authors: de Brugada
authors: Geoffrey
authors: G
authors: Hall
mesh_terms: D000818:Animals; D001288:Attention / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D002794:Choline / Q000008:administration & dosage / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D007266:Inhibition, Psychological; D008082:Lipotropic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011581:Psychological Tests; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008082:Lipotropic Agents; D002794:Choline