title: Role of proteomics in the discovery of autism biomarkers.
abstract: The epidemiology of autism is continuously increasing all over the world with social, behavioural and economical burdens. Autism is considered as a multi-factorial disorder, influenced by genetic, neurological, environmental and immunological aspects. Autism is still believed to be incurable disorder with little information about the role of proteins patterns in the diagnosis of the disease. Knowing the applications of proteomic tools, it is possible to identify quantitative and qualitative protein patterns in a wide variety of tissues and body fluids such as blood, urine, saliva and  cerebrospinal fluid in order to establish specific diagnostic and prognostic biomarkers. The aim of this review is to provide an overview of the various protocols available for proteomics by using mass spectrometry analysis, discuss reports in which these techniques have been previously applied in biomarker discovery for the diagnosis of autism, and consider the future development of this area of research.
authors: Autism Research and Treatment Centre, Al-Amodi Autism Research Chair, Department of Physiology, King Saud University, Riyadh, Saudi Arabia.
authors: Laila
authors: L
authors: Al-Ayadhi
authors: Dost Muhammad
authors: DM
authors: Halepoto
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D001826:Body Fluids / Q000737:chemistry / Q000378:metabolism*; D002853:Chromatography, Liquid; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D013058:Mass Spectrometry; D040901:Proteomics / Q000379:methods* / Q000639:trends
chemical_list: D015415:Biomarkers