title: Sudden unexpected death in epilepsy: from the lab to the clinic setting.
abstract: Sudden unexpected death in epilepsy (SUDEP) is defined as sudden, unexpected, witnessed or unwitnessed, non-traumatic, and non-drowning death in a patient with epilepsy. Sudden unexpected death in epilepsy is probably the most common cause of epilepsy-related deaths. Many predisposing and initiating factors may coexist and contribute to SUDEP, but the mechanisms are poorly understood. Cardiac and respiratory deregulation seems to have a major role in SUDEP. Here, we review several advances in understanding the mechanisms involved in SUDEP.
authors: Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. v.c.terra@gmail.com
authors: Vera C
authors: VC
authors: Terra
authors: Roberta
authors: R
authors: Cysneiros
authors: Esper A
authors: EA
authors: Cavalheiro
authors: Fulvio A
authors: FA
authors: Scorza
mesh_terms: D000818:Animals; D003645:Death, Sudden / Q000209:etiology*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000150:complications*; D006801:Humans; D012307:Risk Factors; D057170:Translational Research, Biomedical