title: Type 2 diabetes in Mauritania: prevalence of the undiagnosed diabetes, influence of family history and maternal effect.
abstract: OBJECTIVE
  We estimated the prevalence of undiagnosed diabetes, analyzed the influence of family history on the occurrence of T2D and evaluated its aggregation pattern in the Mauritanian population.
  
  
  METHODS
  The prevalence of unknown diabetes was obtained using data compiled from 1278 Mauritanian adults applying a questionnaire and fasting serum glucose tests. Detailed family history of diabetes and clinical characteristics were gathered from 421 T2D patients.
  
  
  RESULTS
  The prevalence of undiagnosed diabetes was 4.7 ± 1.2% in the studied population (3.1% in men and 6.4% in women). 27% of T2D patients reported at least one relative with diabetes. Association between family history and diabetes was higher among first degree compared to second degree relatives (p=0.003). We observed more probands with an affected mother than those who have a father with diabetes (p = 0.002), suggesting a preferential maternal effect which did not extend to second degree relatives.
  
  
  CONCLUSIONS
  These results show that the prevalence of diabetes in the Mauritanian population could be higher than currently thought. Family history screening may be used in the management of this condition in Mauritania.
authors: Laboratory of Biochemistry and Molecular Biology, Faculté des Sciences et Techniques, B.P. 5026, Nouakchott, Mauritania.
authors: Ghlana
authors: G
authors: Meiloud
authors: Imen
authors: I
authors: Arfa
authors: Rym
authors: R
authors: Kefi
authors: Isselmou
authors: I
authors: Abdelhamid
authors: Fatimetou
authors: F
authors: Veten
authors: Khaled
authors: K
authors: Lasram
authors: Nizar
authors: N
authors: Ben Halim
authors: Abdallahi
authors: A
authors: Sidi Mhamed
authors: Abdoulaye
authors: A
authors: Samb
authors: Sonia
authors: S
authors: Abdelhak
authors: Ahmed Ould
authors: AO
authors: Houmeida
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D016009:Chi-Square Distribution; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D005215:Fasting / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D006306:Health Surveys; D040941:Heredity; D006801:Humans; D008297:Male; D008435:Mauritania / Q000453:epidemiology; D008875:Middle Aged; D009035:Mothers / Q000706:statistics & numerical data*; D010375:Pedigree; D010641:Phenotype; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose