title: Metronomic cyclophosphamide: an alternative treatment for hepatic epithelioid hemangioendothelioma.
abstract: Hepatic epithelioid hemangioendothelioma is a rare liver mesenchymatous tumor with an epithelial aspect developed from endothelial cells with a lack of validated therapeutic options at metastatic stage. Metronomic chemotherapy has been described as an anti-angiogenic therapy leading to the depletion of circulating endothelial progenitors. We report the results of two patients treated for metastatic hemangioendothelioma with metronomic cyclophosphamide chemotherapy. Following initiation of metronomic cyclophosphamide chemotherapy (50mg once a day continuously), the two patients exhibited significant clinical improvement and decrease in metastasis size without any clinically relevant side-effect. Metronomic cyclophosphamide could be proposed as a new therapeutic option to treat metastatic hepatic epithelioid hemangioendothelioma.
authors: Department of Digestive Surgery and Liver Transplantation, University Hospital of Besançon, France.
authors: Zaher
authors: Z
authors: Lakkis
authors: Stefano
authors: S
authors: Kim
authors: Eric
authors: E
authors: Delabrousse
authors: Marine
authors: M
authors: Jary
authors: Thierry
authors: T
authors: Nguyen
authors: Georges
authors: G
authors: Mantion
authors: Bruno
authors: B
authors: Heyd
authors: Catherine
authors: C
authors: Lassabe
authors: Christophe
authors: C
authors: Borg
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide