title: Dynamics of cellular immune responses in the acute phase of dengue virus infection.
abstract: In this study, we examined the dynamics of cellular immune responses in the acute phase of dengue virus (DENV) infection in a marmoset model. Here, we found that DENV infection in marmosets greatly induced responses of CD4/CD8 central memory T and NKT cells. Interestingly, the strength of the immune response was greater in animals infected with a dengue fever strain than in those infected with a dengue hemorrhagic fever strain of DENV. In contrast, when animals were re-challenged with the same DENV strain used for primary infection, the neutralizing antibody induced appeared to play a critical role in sterilizing inhibition against viral replication, resulting in strong but delayed responses of CD4/CD8 central memory T and NKT cells. The results in this study may help to better understand the dynamics of cellular and humoral immune responses in the control of DENV infection.
authors: Tsukuba Primate Research Center, National Institute of Biomedical Innovation, 1-1 Hachimandai, Tsukuba, Ibaraki 305-0843, Japan. yoshida.tomoyuki.4w@kyoto-u.ac.jp
authors: Tomoyuki
authors: T
authors: Yoshida
authors: Tsutomu
authors: T
authors: Omatsu
authors: Akatsuki
authors: A
authors: Saito
authors: Yuko
authors: Y
authors: Katakai
authors: Yuki
authors: Y
authors: Iwasaki
authors: Terue
authors: T
authors: Kurosawa
authors: Masataka
authors: M
authors: Hamano
authors: Atsunori
authors: A
authors: Higashino
authors: Shinichiro
authors: S
authors: Nakamura
authors: Tomohiko
authors: T
authors: Takasaki
authors: Yasuhiro
authors: Y
authors: Yasutomi
authors: Ichiro
authors: I
authors: Kurane
authors: Hirofumi
authors: H
authors: Akari
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002144:Callithrix / Q000276:immunology / Q000821:virology; D003715:Dengue / Q000276:immunology* / Q000821:virology; D003716:Dengue Virus / Q000276:immunology*; D007111:Immunity, Cellular / Q000276:immunology; D056724:Immunity, Humoral / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology; D008297:Male; D055611:Natural Killer T-Cells / Q000276:immunology; D019595:Severe Dengue / Q000276:immunology / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology; D014779:Virus Replication / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing