title: Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 diabetes.
abstract: It has been increasingly accepted that chronic subacute inflammation plays an important role in the development of insulin resistance and type 2 diabetes in animals and humans. Particularly supporting this is that suppression of systemic inflammation in type 2 diabetes improves glycemic control; this also points to a new potential therapeutic target for the treatment of type 2 diabetes. Recent studies strongly suggest that obesity-induced inflammation is mainly mediated by tissue resident immune cells, with particular attention being focused on adipose tissue macrophages (ATMs). This review delineates the current progress made in understanding obesity-induced inflammation and the roles ATMs play in this process.
authors: Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02115, USA. jongsoon.lee@joslin.harvard.edu
authors: Jongsoon
authors: J
authors: Lee
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism / Q000473:pathology*; D009765:Obesity / Q000378:metabolism / Q000473:pathology*
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