title: Confirming the diversity of the brain after normalization: an approach based on identity authentication.
abstract: During the development of neuroimaging, numerous analyses were performed to identify population differences, such as studies on age, gender, and diseases. Researchers first normalized the brain image and then identified features that represent key differences between groups. In these studies, the question of whether normalization (a pre-processing step widely used in neuroimaging studies) reduces the diversity of brains was largely ignored. There are a few studies that identify the differences between individuals after normalization. In the current study, we analyzed brain diversity on an individual level, both qualitatively and quantitatively. The main idea was to utilize brain images for identity authentication. First, the brain images were normalized and registered. Then, a pixel-level matching method was developed to compute the identity difference between different images for matching. Finally, by analyzing the performance of the proposed brain recognition strategy, the individual differences in brain images were evaluated. Experimental results on a 150-subject database showed that the proposed approach could achieve a 100% identification ratio, which indicated distinct differences between individuals after normalization. Thus, the results proved that after the normalization stage, brain images retain their main distinguishing information and features. Based on this result, we suggest that diversity (individual differences) should be considered when conducting group analysis, and that this approach may facilitate group pattern classification.
authors: Department of Automatic Control, College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, People's Republic of China.
authors: Fanglin
authors: F
authors: Chen
authors: Longfei
authors: L
authors: Su
authors: Yadong
authors: Y
authors: Liu
authors: Dewen
authors: D
authors: Hu
mesh_terms: D000465:Algorithms; D044822:Biodiversity; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D011859:Radiography
references: Hum Brain Mapp. 2008 Nov;29(11):1265-75
references: 17894392
references: IEEE Trans Med Imaging. 2008 Jan;27(1):111-28
references: 18270067
references: Neuroimage. 2010 Jul 1;51(3):943-51
references: 20211265
references: Neuroimage. 2010 Apr 15;50(3):910-9
references: 20079440
references: Neuroimage. 2011 Jan 1;54(1):191-202
references: 20688177
references: Cereb Cortex. 2011 Feb;21(2):449-58
references: 20562318
references: Neuroimage. 2012 Oct 1;62(4):2296-314
references: 22387165
references: Psychiatry Res. 2010 Apr 30;182(1):9-13
references: 20227253
references: Cereb Cortex. 2012 Nov;22(11):2653-61
references: 22169231
references: Neuroimage. 2009 Jul 1;46(3):786-802
references: 19195496
references: Neuroimage. 2008 Mar 1;40(1):110-20
references: 18191584
references: Biophys J. 1993 Mar;64(3):803-12
references: 8386018
references: Neuroimage. 2006 Oct 15;33(1):63-71
references: 16908198
references: IEEE Trans Image Process. 2009 Jul;18(7):1665-70
references: 19414288
references: Neuroimage. 2012 Apr 15;60(3):1622-9
references: 22289801
references: Hum Brain Mapp. 2011 Jul;32(7):1050-8
references: 20607753
references: Neurobiol Aging. 2011 Feb;32(2):354-68
references: 19282066
references: Science. 2010 Sep 10;329(5997):1358-61
references: 20829489
references: Stat Methods Med Res. 1997 Sep;6(3):267-99
references: 9339500
references: Brain Inj. 2011;25(9):870-81
references: 21631188
references: IEEE Trans Pattern Anal Mach Intell. 2011 Dec;33(12):2465-76
references: 21576740
references: Hum Brain Mapp. 1999;7(4):254-66
references: 10408769
references: J Cogn Neurosci. 2010 Dec;22(12):2677-84
references: 19929323
references: Brain Res. 2011 Mar 22;1380:138-45
references: 20920490
references: Neuroimage. 2007 Oct 15;38(1):95-113
references: 17761438
references: Neuroimage. 2010 Jan 15;49(2):1750-9
references: 19796692
references: Neuroimage. 2012 Apr 15;60(3):1608-21
references: 22245343
references: Neuroimage. 2011 May 1;56(1):212-9
references: 21272654
references: Neuroimage. 2007 Jan 1;34(1):235-42
references: 17045492
references: Neuroimage. 1997 Nov;6(4):344-52
references: 9417976
references: Neuroimage. 1997 Oct;6(3):209-17
references: 9344825
references: Science. 2009 Oct 16;326(5951):399-403
references: 19833961
references: Neurosci Biobehav Rev. 2010 Apr;34(5):721-33
references: 19850077
references: J Cogn Neurosci. 2007 Sep;19(9):1498-507
references: 17714011
references: IEEE Trans Med Imaging. 2007 Jan;26(1):93-105
references: 17243588