title: Calcium dynamics in vascular smooth muscle.
abstract: Smooth muscle cells are ultimately responsible for determining vascular luminal diameter and blood flow. Dynamic changes in intracellular calcium are a critical mechanism regulating vascular smooth muscle contractility. Processes influencing intracellular calcium are therefore important regulators of vascular function with physiological and pathophysiological consequences. In this review we discuss the major dynamic calcium signals identified and characterized in vascular smooth muscle cells. These signals vary with respect to their mechanisms of generation, temporal properties, and spatial distributions. The calcium signals discussed include calcium waves, junctional calcium transients, calcium sparks, calcium puffs, and L-type calcium channel sparklets. For each calcium signal we address underlying mechanisms, general properties, physiological importance, and regulation.
authors: Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA. Gregory.Amberg@colostate.edu
authors: Gregory C
authors: GC
authors: Amberg
authors: Manuel F
authors: MF
authors: Navedo
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D009124:Muscle Proteins / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*
chemical_list: D020746:Calcium Channels, L-Type; D009124:Muscle Proteins; D002118:Calcium
references: J Physiol. 1992;451:525-37
references: 1403823
references: Circ Res. 2008 Feb 1;102(2):e1-e11
references: 18174462
references: Microcirculation. 2013 Apr;20(3):269-77
references: 23140521
references: Am J Physiol Cell Physiol. 2010 Nov;299(5):C1195-202
references: 20826763
references: Circ Res. 2010 Oct 15;107(8):1002-10
references: 20798361
references: EMBO J. 1994 Nov 1;13(21):5026-31
references: 7957068
references: J Mol Cell Cardiol. 2009 Oct;47(4):436-44
references: 19616004
references: J Gen Physiol. 2010 Aug;136(2):143-7
references: 20660657
references: Am J Physiol Cell Physiol. 2010 Feb;298(2):C211-20
references: 19846755
references: Nature. 2001 Mar 29;410(6828):592-6
references: 11279498
references: Acta Physiol Scand. 1998 Dec;164(4):577-87
references: 9887980
references: Cold Spring Harb Perspect Biol. 2011 Sep 01;3(9):a004549
references: 21709182
references: Physiol Rev. 2010 Jan;90(1):113-78
references: 20086075
references: Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H617-25
references: 15072954
references: Am J Physiol Cell Physiol. 2001 Dec;281(6):C1769-75
references: 11698234
references: Am J Physiol Cell Physiol. 2005 Jan;288(1):C122-31
references: 15355851
references: J Cell Biol. 1972 Mar;52(3):690-718
references: 5061887
references: Circ Res. 2010 Mar 5;106(4):748-56
references: 20110531
references: Am J Physiol. 1999 Jul;277(1):C139-51
references: 10409117
references: Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1523-32
references: 17114244
references: Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11112-7
references: 16040810
references: Acta Pharmacol Sin. 2006 Dec;27(12):1515-25
references: 17112404
references: Exp Physiol. 2009 Jan;94(1):31-7
references: 18931047
references: Cell Calcium. 2012 Jan;51(1):82-93
references: 22153976
references: J Clin Invest. 2003 Dec;112(12):1895-905
references: 14679185
references: Trends Pharmacol Sci. 2001 Oct;22(10):505-12
references: 11583807
references: Circ Res. 2002 Sep 20;91(6):454-6
references: 12242262
references: Nature. 2000 Oct 19;407(6806):870-6
references: 11057658
references: Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1472-83
references: 20173044
references: EMBO J. 2003 Nov 17;22(22):6027-34
references: 14609949
references: Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3106-13
references: 16920810
references: J Physiol. 2000 Sep 1;527 Pt 2:315-24
references: 10970432
references: Am J Physiol Cell Physiol. 2010 Aug;299(2):C279-88
references: 20427713
references: J Physiol. 1999 Aug 1;518 ( Pt 3):815-24
references: 10420017
references: Am J Physiol Cell Physiol. 2000 Feb;278(2):C235-56
references: 10666018
references: Science. 1993 Oct 29;262(5134):740-4
references: 8235594
references: J Physiol. 2003 Jun 15;549(Pt 3):801-8
references: 12740429
references: J Physiol. 2002 Aug 1;542(Pt 3):743-62
references: 12154176
references: J Physiol. 2002 Oct 1;544(Pt 1):71-84
references: 12356881
references: Am J Physiol Cell Physiol. 2012 May 1;302(9):C1382-93
references: 22322977
references: Invest Ophthalmol Vis Sci. 2012 May 17;53(6):3059-66
references: 22427579
references: Science. 2012 May 4;336(6081):597-601
references: 22556255
references: Pflugers Arch. 2012 Jul;464(1):51-62
references: 22555917
references: Science. 1995 Oct 27;270(5236):633-7
references: 7570021
references: J Physiol. 1996 Dec 1;497 ( Pt 2):413-22
references: 8961184
references: Am J Physiol Cell Physiol. 2000 Nov;279(5):C1528-39
references: 11029300
references: Am J Physiol Cell Physiol. 2001 Sep;281(3):C1029-37
references: 11502581
references: J Clin Invest. 2003 Sep;112(5):717-24
references: 12952920
references: Curr Biol. 1996 Jul 1;6(7):855-65
references: 8805305
references: J Physiol. 1998 Apr 1;508 ( Pt 1):199-209
references: 9490839
references: J Physiol. 2012 Apr 15;590(8):1849-69
references: 22331418
references: Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1359-70
references: 17526649
references: Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1749-54
references: 22307641
references: J Gen Physiol. 2006 Jun;127(6):611-22
references: 16702354
references: J Physiol. 2007 Feb 15;579(Pt 1):187-201
references: 17158168
references: Am J Physiol. 1997 Dec;273(6):C2090-5
references: 9435516
references: Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2285-94
references: 21984539
references: J Gen Physiol. 1996 Apr;107(4):459-72
references: 8722560
references: Am J Physiol Cell Physiol. 2001 Aug;281(2):C439-48
references: 11443043
references: J Physiol. 1998 Apr 1;508 ( Pt 1):211-21
references: 9490841
references: J Cell Sci. 2001 Nov;114(Pt 22):3979-89
references: 11739630
references: Circ Res. 2003 Nov 14;93(10):965-71
references: 14551242
references: Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15623-8
references: 18832165
references: Am J Physiol Cell Physiol. 2000 Jul;279(1):C126-35
references: 10898724
references: J Physiol. 1986 Dec;381:385-406
references: 2442353
references: Cell Calcium. 2001 May;29(5):327-34
references: 11292389
references: Am J Physiol. 1998 May;274(5):C1346-55
references: 9612222