title: Conformational ensembles in GPCR activation.
abstract: Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.
authors: Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
authors: Eyal
authors: E
authors: Vardy
authors: Bryan L
authors: BL
authors: Roth