title: Morbidities in rapid eye movement sleep behavior disorder.
abstract: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD, RBD without any obvious comorbid major neurological disease), is strongly associated with numerous comorbid conditions. The most prominent is that with neurodegenerative disorders, especially synuclein-mediated disorders, above all Parkinson disease (PD). Idiopathic RBD is an important risk factor for the development of synucleinopathies. Comorbidity studies suggest that iRBD is associated with a number of other potential pre-motor manifestations of synucleinopathies such as, cognitive and olfactory impairment, reduced autonomic function, neuropsychiatric manifestations and sleep complaints. Furthermore, patients with PD and RBD may have worse prognosis in terms of impaired cognitive function and overall morbidity/mortality; in dementia, the presence of RBD is strongly associated with clinical hallmarks and pathological findings of dementia with Lewy bodies. These findings underline the progressive disease process, suggesting involvement of more brain regions in patients with a more advanced disease stage. RBD is also associated with narcolepsy, and it is likely that RBD associated with narcolepsy is a distinct subtype associated with different comorbidities. RBD is also associated with antidepressant medications, autoimmune conditions, and, in rare cases, brainstem lesions.
authors: Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, University of Copenhagen, Glostrup, Copenhagen, Denmark. Poul.joergen.jennum@regionh.dk
authors: Poul
authors: P
authors: Jennum
authors: Geert
authors: G
authors: Mayer
authors: Yo-El
authors: YE
authors: Ju
authors: Ron
authors: R
authors: Postuma
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000453:epidemiology; D003072:Cognition Disorders / Q000453:epidemiology / Q000503:physiopathology; D015897:Comorbidity; D003866:Depressive Disorder / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D009017:Morbidity; D018482:Muscle, Skeletal / Q000503:physiopathology; D009290:Narcolepsy / Q000453:epidemiology* / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000453:epidemiology* / Q000503:physiopathology; D010300:Parkinson Disease / Q000453:epidemiology* / Q000503:physiopathology; D020187:REM Sleep Behavior Disorder / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D000928:Antidepressive Agents
keywords: Comorbidity; Morbidity; Narcolepsy; Neurodegenerative disorder; Parkinsonism; REM Sleep Behavior Disorder
references: Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S87-92
references: 20083017
references: Sleep Med Rev. 2005 Jun;9(3):185-200
references: 15893249
references: Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:6063-6
references: 22255722
references: Neurology. 2010 Jan 19;74(3):239-44
references: 20083800
references: Conscious Cogn. 2011 Dec;20(4):1021-6
references: 21071244
references: Brain. 2012 Jun;135(Pt 6):1860-70
references: 22561644
references: Sleep Med. 2005 May;6(3):253-8
references: 15854856
references: Mov Disord. 2012 Mar;27(3):428-31
references: 22173891
references: Ann Neurol. 2003 Jun;53(6):774-80
references: 12783424
references: Mov Disord. 2010 Oct 30;25(14):2304-10
references: 20669316
references: Mov Disord. 2008 Sep 15;23(12):1665-72
references: 18709686
references: Neurology. 2006 Dec 26;67(12):2236-8
references: 17190953
references: Neurology. 2010 Nov 16;75(20):1762-3
references: 20962292
references: Mov Disord. 2012 Jun;27(7):888-94
references: 22555939
references: Sleep Med. 2012 Feb;13(2):211-2
references: 21924952
references: JAMA. 1987 Apr 3;257(13):1786-9
references: 3820495
references: Neurology. 2000 Sep 26;55(6):894-5
references: 10994023
references: Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:5093-6
references: 21096034
references: Sleep Med. 2007 Nov;8(7-8):784-6
references: 17569582
references: Sleep Med. 2011 Jun;12(6):572-7
references: 21570344
references: Sleep Breath. 2013 Mar;17(1):209-15
references: 22367462
references: Neurology. 2011 Aug 30;77(9):875-82
references: 21849645
references: Sleep. 2007 Aug;30(8):1019-25
references: 17702272
references: Sleep. 2007 Jun;30(6):767-9
references: 17580598
references: Mov Disord. 2008 Jul 30;23(10):1441-5
references: 18512749
references: Sleep Med. 2011 Mar;12(3):284-8
references: 21317034
references: Lancet Neurol. 2006 Jul;5(7):572-7
references: 16781987
references: Mov Disord. 2012 May;27(6):677-89
references: 22447623
references: Ann Neurol. 2009 Jul;66(1):39-47
references: 19670440
references: Neurology. 1996 May;46(5):1250-4
references: 8628461
references: Neurology. 1996 Feb;46(2):388-93
references: 8614500
references: Mov Disord. 2010 Oct 30;25(14):2269-71
references: 20976735
references: Mov Disord. 2012 May;27(6):720-6
references: 22322798
references: J Neurol Sci. 2011 Nov 15;310(1-2):4-8
references: 21679972
references: Mov Disord. 2001 Jul;16(4):622-30
references: 11481685
references: Sleep Med. 2008 Jul;9(5):473-4
references: 18024175
references: Neurology. 2011 Sep 13;77(11):1048-54
references: 21832215
references: Lancet. 1971 Jul 24;2(7717):175-9
references: 4104845
references: Brain. 2005 Nov;128(Pt 11):2535-45
references: 16000335
references: J Nerv Ment Dis. 2011 May;199(5):329-34
references: 21543952
references: Neuro Endocrinol Lett. 2010;31(5):631-4
references: 21173745
references: Brain. 2009 Dec;132(Pt 12):3298-307
references: 19843648
references: Lancet Neurol. 2006 May;5(5):424-32
references: 16632313
references: Mov Disord. 2012 Jan;27(1):72-8
references: 22038951
references: J Neurol. 2012 Aug;259(8):1606-12
references: 22231870
references: Neurology. 2008 Sep 16;71(12):955; author reply 955-6
references: 18794502
references: J Clin Psychiatry. 2010 Aug;71(8):1101-3
references: 20797385
references: Neurology. 2006 Apr 25;66(8):1277-9
references: 16636256
references: J Neurol Neurosurg Psychiatry. 1998 May;64(5):683-5
references: 9598693
references: Ann N Y Acad Sci. 2010 Jan;1184:15-54
references: 20146689
references: Brain. 2007 Nov;130(Pt 11):2770-88
references: 17412731
references: Neurology. 2007 Nov 6;69(19):1843-9
references: 17984452
references: Sleep. 2007 Jul;30(7):844-9
references: 17682654
references: Ann Neurol. 2006 Jan;59(1):178-81
references: 16278841
references: Mov Disord. 2012 Jul;27(8):996-1003
references: 22733427
references: J Clin Sleep Med. 2011 Apr 15;7(2):211-3
references: 21509338
references: Neurology. 2012 Jul 31;79(5):428-34
references: 22744670
references: Sleep Med. 2013 Aug;14(8):788-94
references: 22841026
references: Electroencephalogr Clin Neurophysiol. 1965 May;18:554-66
references: 14296834
references: Sleep Med. 2009 Jun;10(6):641-5
references: 19109063
references: Ann Neurol. 2012 Jan;71(1):49-56
references: 22275251
references: Mov Disord. 2011 Oct;26 Suppl 3:S42-80
references: 22021174
references: Mov Disord. 2003 Oct;18(10):1179-83
references: 14534924
references: Int J Geriatr Psychiatry. 2007 Jun;22(6):543-8
references: 17133656
references: Neurology. 2002 Dec 24;59(12):1889-94
references: 12499479
references: J Neurol Neurosurg Psychiatry. 2009 May;80(5):578-9
references: 19372296
references: Sleep. 2004 Mar 15;27(2):317-21
references: 15124729
references: J Clin Neurophysiol. 2001 Mar;18(2):148-57
references: 11435805
references: Mov Disord. 2011 Jul;26(8):1529-33
references: 21538520
references: Eur J Epidemiol. 2011 Jun;26 Suppl 1:S1-58
references: 21626386
references: Brain. 2010 Feb;133(Pt 2):568-79
references: 20129934
references: Mov Disord. 2004 Jun;19(6):719-23
references: 15197719
references: Neurology. 2012 Aug 14;79(7):651-8
references: 22855866
references: Sleep Med. 2012 Aug;13(7):919-25
references: 22726269
references: Neurology. 2009 Apr 14;72(15):1296-300
references: 19109537
references: Mov Disord. 2012 Sep 1;27(10):1255-61
references: 22791632
references: Sleep Med. 2009 Jan;10(1):143-6
references: 18226960
references: Neurology. 2006 Nov 14;67(9):1618-22
references: 17101893
references: J Clin Sleep Med. 2011 Dec 15;7(6):653-8
references: 22171205
references: Mult Scler. 2007 Jul;13(6):805-8
references: 17613610
references: Sleep. 2011 Feb 01;34(2):219-23
references: 21286243
references: J Neurol. 2012 Jun;259(6):1056-61
references: 22064976
references: Sleep Med. 2002 Sep;3(5):437-9
references: 14592179
references: J Am Geriatr Soc. 2011 May;59(5):928-9
references: 21568960
references: Arch Neurol. 2008 Apr;65(4):482-8
references: 18413470
references: J Neurol Neurosurg Psychiatry. 2012 Apr;83(4):470-2
references: 22250185
references: Sleep. 2007 Aug;30(8):1026-32
references: 17702273
references: Sleep Med. 2010 Jun;11(6):534-9
references: 20462792
references: J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):427-9
references: 17369596
references: Sleep. 2002 Dec;25(8):867-70
references: 12489892
references: Sleep. 2011 May 01;34(5):561-2
references: 21532947
references: Sleep Med. 2009 Oct;10(9):1059-62
references: 19345142