title: Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.
abstract: Fibromyalgia (FM) is characterized by generalized pain and chronic fatigue of unknown etiology. To evaluate the role of oxidative stress in this disorder, we measured plasma levels of ubiquinone-10, ubiquinol-10, free cholesterol (FC), cholesterol esters (CE), and free fatty acids (FFA) in patients with juvenile FM (n=10) and in healthy control subjects (n=67). Levels of FC and CE were significantly increased in juvenile FM as compared with controls, suggesting the presence of hypercholesterolemia in this disease. However, plasma level of ubiquinol-10 was significantly decreased and the ratio of ubiquinone-10 to total coenzyme Q10 (%CoQ10) was significantly increased in juvenile FM relative to healthy controls, suggesting that FM is associated with coenzyme Q10 deficiency and increased oxidative stress. Moreover, plasma level of FFA was significantly higher and the content of polyunsaturated fatty acids (PUFA) in total FFA was significantly lower in FM than in controls, suggesting increased tissue oxidative damage in juvenile FM. Interestingly, the content of monoenoic acids, such as oleic and palmitoleic acids, was significantly increased in FM relative to controls, probably to compensate for the loss of PUFA. Next, we examined the effect of ubiquinol-10 supplementation (100 mg/day for 12 weeks) in FM patients. This resulted in an increase in coenzyme Q10 levels and a decrease in %CoQ10. No changes were observed in FFA levels or their composition. However, plasma levels of FC and CE significantly decreased and the ratio of FC to CE also significantly decreased, suggesting that ubiquinol-10 supplementation improved cholesterol metabolism. Ubiquinol-10 supplementation also improved chronic fatigue scores as measured by the Chalder Fatigue Scale.
authors: Department of Pediatrics, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
authors: Takako
authors: T
authors: Miyamae
authors: Manabu
authors: M
authors: Seki
authors: Tomoko
authors: T
authors: Naga
authors: Shinya
authors: S
authors: Uchino
authors: Haruki
authors: H
authors: Asazuma
authors: Takuma
authors: T
authors: Yoshida
authors: Yuki
authors: Y
authors: Iizuka
authors: Masako
authors: M
authors: Kikuchi
authors: Tomoyuki
authors: T
authors: Imagawa
authors: Yutaka
authors: Y
authors: Natsumeda
authors: Shumpei
authors: S
authors: Yokota
authors: Yorihiro
authors: Y
authors: Yamamoto
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism; D001259:Ataxia / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D002784:Cholesterol / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D005221:Fatigue / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005356:Fibromyalgia / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D028361:Mitochondrial Diseases / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D018908:Muscle Weakness / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D019301:Oleic Acid / Q000097:blood; D018384:Oxidative Stress; D010147:Pain Measurement / Q000379:methods; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000172:deficiency / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D005229:Fatty Acids, Monounsaturated; D005230:Fatty Acids, Nonesterified; D014451:Ubiquinone; C008757:palmitoleic acid; D019301:Oleic Acid; C026663:ubiquinol-10; D002784:Cholesterol; C024989:coenzyme Q10
references: Z Rheumatol. 1998;57 Suppl 2:47-51
references: 10025082
references: Arthritis Rheum. 1990 Feb;33(2):160-72
references: 2306288
references: Redox Rep. 1996 Apr;2(2):121-5
references: 27405950
references: Pediatr Int. 2010 Feb;52(1):80-8
references: 19496977
references: Exp Mol Pathol. 2007 Aug;83(1):84-92
references: 17239370
references: Free Radic Res. 2003 Jun;37(6):603-9
references: 12868487
references: Arthritis Res Ther. 2010;12(1):R17
references: 20109177
references: Altern Ther Health Med. 2002 May-Jun;8(3):42-55; quiz 56, 138
references: 12017500
references: Mayo Clin Proc. 2011 Sep;86(9):907-11
references: 21878603
references: Scand J Clin Lab Invest. 1987 Oct;47(6):613-7
references: 3672034
references: Biochem Biophys Res Commun. 1999 Apr 2;257(1):244-8
references: 10092541
references: Acta Reumatol Port. 2008 Jul-Sep;33(3):345-51
references: 18846013
references: J Biol Chem. 1987 Feb 5;262(4):1479-84
references: 3805035
references: Redox Rep. 2009;14(6):251-8
references: 20003710
references: Clin Biochem. 2009 May;42(7-8):732-5
references: 19133251
references: Free Radic Biol Med. 1987;3(5):359-61
references: 3319802
references: J Neuroimmunol. 2012 Jan 18;242(1-2):33-8
references: 22126705
references: Clin Rheumatol. 2009 Apr;28(4):435-8
references: 19089486
references: Br Med J. 1974 Jul 6;3(5922):18-21
references: 4835464
references: PLoS One. 2012;7(4):e35677
references: 22532869
references: Neuropsychiatr Dis Treat. 2009;5:597-610
references: 19966907
references: Biochem Biophys Res Commun. 1984 Oct 15;124(1):229-35
references: 6497879
references: Rheumatol Int. 2006 May;26(7):585-97
references: 16328420
references: Crit Care Med. 1996 Feb;24(2):241-6
references: 8605795
references: Clin Rheumatol. 2006 May;25(3):300-3
references: 16200384
references: Yonsei Med J. 2000 Oct;41(5):541-5
references: 11079612
references: Mitochondrion. 2011 Jul;11(4):623-5
references: 21496502
references: Jpn J Pharmacol. 1977 Jun;27(3):429-35
references: 144207
references: Psychol Rep. 2008 Dec;103(3):682-90
references: 19320199
references: Biochem Biophys Res Commun. 1998 Jun 9;247(1):166-70
references: 9636673
references: FASEB J. 2000 Jan;14(1):87-94
references: 10627283
references: Free Radic Res. 1998 Feb;28(2):109-14
references: 9645387
references: Curr Rheumatol Rep. 2001 Apr;3(2):165-71
references: 11286673
references: J Psychosom Res. 1993;37(2):147-53
references: 8463991