title: OLR1, PON1 and MTHFR gene polymorphisms, conventional risk factors and the severity of coronary atherosclerosis in a Chinese Han population.
abstract: OBJECTIVE
  To explore the association between six single-nucleotide polymorphisms in OLR1, PON1, MTHFR gene and the angiographical characteristics of coronary atherosclerosis to determine if any of the conventional factors correlate with genetic polymorphisms in the advent of the disease.
  
  
  METHODS
  We examined rs1801131, rs1801133, rs3736232, rs3736234, rs854563 and rs662 by TaqMan® SNP Genotyping Assays in 1075 subjects that underwent angiography. The angiographical characteristics of coronary atherosclerosis were defined by the Gensini Score system.
  
  
  RESULTS
  The T allele of rs1801133 was associated with coronary atherosclerosis severity with the OR = 1.49, 95% CI = 1.04-2.14. In MTHFR gene, haplotype T-A was a susceptibility haplotype to coronary atherosclerosis (OR = 1.27, 95% CI = 1.06-1.51) whereas haplotype C-A had a protective effect (OR = 0.83, 95% CI = 0.70-0.99). In addition, several synergistic effects between rs1801133 and conventional risk factors such as diabetes and smoking were found.
  
  
  CONCLUSIONS
  Collectively, the results demonstrate that the T allele of rs1801133 conferred an increased risk for coronary atherosclerosis. The MTHFR C-A haplotype was a protective haplotype, while T-A haplotype was a susceptibility haplotype. The presence of the T allele of rs1801133 increases the odds of coronary atherosclerosis severity when associated with conventional risk factors.
authors: Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: Yan
authors: Y
authors: Gu
authors: Zhe
authors: Z
authors: Liu
authors: Li
authors: L
authors: Li
authors: Chang-Yan
authors: CY
authors: Guo
authors: Chun-Jian
authors: CJ
authors: Li
authors: Lian-Sheng
authors: LS
authors: Wang
authors: Zhi-Jian
authors: ZJ
authors: Yang
authors: Wen-Zhu
authors: WZ
authors: Ma
authors: En-Zhi
authors: EZ
authors: Jia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D043303:Aryldialkylphosphatase / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051127:Scavenger Receptors, Class E / Q000235:genetics*; D012907:Smoking
chemical_list: C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D043303:Aryldialkylphosphatase; C468406:PON1 protein, human