title: Management of prenatally diagnosed congenital diaphragmatic hernia.
abstract: Congenital diaphragmatic hernia (CDH) is a congenital anomaly that presents with a broad spectrum of severity that is dependent upon components of pulmonary hypoplasia and pulmonary hypertension. While advances in neonatal care have improved the overall survival of CDH in experienced centers, mortality and morbidity remain high in a subset of CDH infants with severe CDH. Prenatal predictors have been refined for the past two decades and are the subject of another review in this issue. So far, all randomized trials comparing prenatal intervention to standard postnatal therapy have shown no benefit to prenatal intervention. Although recent non-randomized reports of success with fetoscopic endoluminal tracheal occlusion (FETO) and release are promising, prenatal therapy should not be widely adopted until a well-designed prospective randomized trial demonstrating efficacy is performed. The increased survival and subsequent morbidity of CDH survivors has resulted in the need to provide resources for the long-term follow up and support of the CDH population.
authors: Perelman School of Medicine at the University of Pennsylvania, The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Hedrick@email.chop.edu
authors: Holly L
authors: HL
authors: Hedrick
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis; D003131:Combined Modality Therapy; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D005332:Fetoscopy / Q000379:methods; D005333:Fetus / Q000601:surgery; D005820:Genetic Testing; D006548:Hernia, Diaphragmatic / Q000175:diagnosis / Q000628:therapy; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D018743:Perinatal Care / Q000379:methods; D011247:Pregnancy; D011379:Prognosis; D012720:Severity of Illness Index; D014132:Trachea / Q000601:surgery; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal