title: Immunogenetic study in Chinese population with ankylosing spondylitis: are there specific genes recently disclosed?
abstract: OBJECTIVE
  Ankylosing spondylitis (AS) is a systemic, autoimmune disease resulting in the destruction of the affected joints. Over the past 5 years, several new genes or genetic regions associated with AS have been identified in the Chinese population. This paper aims to discuss the major findings and related potential mechanisms of these studies in our population.
  
  
  RESULTS
  In recent years, due to the rapid advances in computational genetics and technology, there has been an increasing list of well-validated genes or genetic regions associated with AS susceptibility. So far, several genes or genetic regions have now been reported in the Han ethnic Chinese population, containing the major histocompatibility complex (MHC), ERAP1, IL-23R, 12q12, 2p15, 5q14.3, and so on. Different hypotheses for disease mechanisms have been investigated on the basis of the functional studies of these genes or genetic regions.
  
  
  CONCLUSIONS
  This paper tries to summarize the association of several candidate genes with risk for AS in the Han ethnic Chinese population and aims to identify the novel inflammatory pathways and provide potential strategies for better therapies.
authors: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, China.
authors: Jiayu
authors: J
authors: Zhai
authors: Ju
authors: J
authors: Rong
authors: Qiuxia
authors: Q
authors: Li
authors: Jieruo
authors: J
authors: Gu
mesh_terms: D000626:Aminopeptidases / Q000276:immunology; D044466:Asian People / Q000235:genetics; D002681:China; D002877:Chromosomes, Human / Q000276:immunology; D019295:Computational Biology; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007125:Immunogenetics; D015778:Minor Histocompatibility Antigens; D018123:Receptors, Interleukin / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology*
chemical_list: D006680:HLA Antigens; C515500:IL23R protein, human; D015778:Minor Histocompatibility Antigens; D018123:Receptors, Interleukin; D000626:Aminopeptidases; C464841:ERAP1 protein, human
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