title: Frequency of amino acid changes associated with resistance to attachment inhibitor BMS-626529 in R5- and X4-tropic HIV-1 subtype B.
abstract: OBJECTIVE
  Resistance to attachment inhibitor BMS-626529, which inhibits the binding of HIV to CD4, involves mutations in the HIV-1 gp120 gene. There is a lack of information on the primary resistance of HIV-1 subtype B to attachment inhibitors, so we decided to investigate.
  
  
  METHODS
  Sequences from 109 attachment-inhibitor-naive patients infected with HIV-1 subtype B were analysed for the presence of previously described in vivo resistance mutations associated with attachment inhibitor BMS-626529 and tropism determination.
  
  
  RESULTS
  The M426L substitution associated with a reduced efficacy of the attachment inhibitor BMS-626529 was present at 7.3%. There was no difference in mutation distribution according to virus tropism (R5 or X4).
  
  
  CONCLUSIONS
  The attachment inhibitor BMS-626529 is suitable for most patients infected with HIV-1 subtype B.
authors: Université Pierre et Marie Curie-Paris 6, UMR S-943 Paris, F-75013, France. cathia.soulie@psl.aphp.fr
authors: Cathia
authors: C
authors: Soulié
authors: Sidonie
authors: S
authors: Lambert-Niclot
authors: Djenaba Bocar
authors: DB
authors: Fofana
authors: Slim
authors: S
authors: Fourati
authors: Zaïna
authors: Z
authors: Ait-Arkoub
authors: Sophie
authors: S
authors: Sayon
authors: Anne
authors: A
authors: Simon
authors: Christine
authors: C
authors: Katlama
authors: Vincent
authors: V
authors: Calvez
authors: Anne-Geneviève
authors: AG
authors: Marcelin
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution / Q000235:genetics*; D019380:Anti-HIV Agents / Q000494:pharmacology*; D015704:CD4 Antigens / Q000187:drug effects; D024882:Drug Resistance, Viral / Q000235:genetics*; D015699:HIV Envelope Protein gp120 / Q000187:drug effects / Q000235:genetics; D015658:HIV Infections / Q000235:genetics / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D010879:Piperazines / Q000494:pharmacology*; D060888:Real-Time Polymerase Chain Reaction; D014230:Triazoles / Q000494:pharmacology*; D056189:Viral Tropism / Q000187:drug effects; D053585:Virus Attachment / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents; C584152:BMS-626529; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D010879:Piperazines; D014230:Triazoles
keywords: gp120; primary resistance; tropism