title: Influence of donor specific HLA antibodies detected by Luminex in kidney graft survival: a multivariate analysis.
abstract: Some studies have demonstrated the clinical relevance of a positive virtual crossmatch in graft survival; nevertheless, other donor and recipient variables influence the outcome of the transplant. The aim of this study was to investigate the relevance of a positive virtual crossmatch in the graft survival performing a multivariate analysis including other pretransplant variables. A total of 879 deceased kidney transplantations were included. Univariate and multivariate analyses were performed using Cox regression model. After performing the multivariate analysis, a positive virtual crossmatch against class I (adjusted HR 6.613; 95% CI 3.222-13.573), class II (adjusted HR 2.419; 95% CI 1.170-5.002) and class I+II (adjusted HR 5.717; 95% CI 1.925-16.975) detected by single antigen Luminex was the variable conferring the greatest relative risk of graft loss. A positive virtual crossmatch predicts a worse kidney graft survival even after correction by other variables and therefore, transplantation of patients with positive virtual crossmatches should be avoided.
authors: Servicio de Inmunología, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina (IBIS), Universidad de Sevilla, CSIC, Seville, Spain.
authors: J L
authors: JL
authors: Caro-Oleas
authors: M F
authors: MF
authors: González-Escribano
authors: M A
authors: MA
authors: Gentil-Govantes
authors: M J
authors: MJ
authors: Acevedo
authors: F M
authors: FM
authors: González-Roncero
authors: G
authors: G
authors: Bernal-Blanco
authors: A
authors: A
authors: Núñez-Roldán
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood / Q000276:immunology*; D005260:Female; D006085:Graft Survival / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007158:Immunologic Techniques / Q000379:methods; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors
chemical_list: D000906:Antibodies; D006680:HLA Antigens