title: [Aromatases inhibitors for breast cancer in menopausal patients].
abstract: OBJECTIVE
  To analyze the litterature data concerning the results of the main international randomized trials of adjuvant Aromarase Inhibitors (AI) in adjuvant setting for early breast cancer and the impact on daily practice in the management of breast cancer.
  
  
  METHODS
  We selected through a litterature review 30 publications concerned the topic of AI RESULTS: They concerned the large ATAC, BIG, MA17 and IES concerning anastrozole, letrozole and exemestane . AI have been compared to tamoxifen in upfront of swich intents and showed a superiority to reduce, mortality rate, controlateral breast cancer risk, a better tolerance profile compared to tamoxifen and a sigificant benefit in term of disease-free survival. These results made a revolution in the adjuvant BC treatment, leading to the systematic use of upfront AI in menopaused patients.
  
  
  CONCLUSIONS
  Adjuvant hormonotherapy in menopaused patients is now based on AI and proved its superiority to tamoxifen in term of distant, controlateral risks reduction and disease-free survival, less for overall survival.
authors: Service de carcinologie médicale, Hôpital Abderrahman Mami, Ariana, Tunis, Tunisie.
authors: Mehdi
authors: M
authors: Afrit
authors: Soumaya
authors: S
authors: Laabidi
authors: Khedija
authors: K
authors: Meddeb
authors: Hela
authors: H
authors: Skhiri
authors: Aymen
authors: A
authors: Zayane
authors: Hamouda
authors: H
authors: Boussen
mesh_terms: D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008593:Menopause
chemical_list: D047072:Aromatase Inhibitors