title: Significant positive association between parathyroid hormone and fat mass and lean mass in chronic hemodialysis patients.
abstract: BACKGROUND
  It has been reported that there is a significant positive relationship between PTH and body weight or body mass index in the general population. However, little is known about this relationship in dialysis patients in whom PTH levels are higher. It is also not known whether fat mass or lean mass is associated with serum PTH among these patients. In the present study, we examined the association of intact PTH with fat mass and lean mass in hemodialysis patients.
  
  
  METHODS
  Serum intact PTH, calcium, and phosphate were measured in 590 hemodialysis patients (age, 60.2 ± 12.2 y; median hemodialysis duration, 59.6 mo; 343 males and 247 females; diabetics, 27.7%). Fat mass and lean mass were measured by dual-energy x-ray absorptiometry.
  
  
  RESULTS
  Intact PTH correlated significantly and positively with body weight and body mass index in all patients. Intact PTH correlated significantly and positively with fat mass and lean mass in males (P < .01), and tended to correlate positively with fat mass and lean mass in females (P < .1). In multiple regression analyses after adjustment for age, gender, hemodialysis duration, calcium, phosphate, vitamin D use, and phosphate binder use, intact PTH was associated significantly with body weight (β = .190; P < .0001), body mass index (β = .177; P < .0001), fat mass (β = .142; P < .0005), and lean mass (β = .192; P < .01). Furthermore, intact PTH was associated significantly and independently with both fat mass and lean mass after adjustment (R(2) = .206; P < .0001).
  
  
  CONCLUSIONS
  Serum intact PTH in chronic hemodialysis patients is associated significantly and positively with body composition of fat mass and lean mass.
authors: Department of Nephrology, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. ish@med.osaka-cu.ac.jp
authors: Eiji
authors: E
authors: Ishimura
authors: Senji
authors: S
authors: Okuno
authors: Naoki
authors: N
authors: Tsuboniwa
authors: Kyoko
authors: K
authors: Norimine
authors: Shinya
authors: S
authors: Fukumoto
authors: Kenjiro
authors: K
authors: Yamakawa
authors: Tomoyuki
authors: T
authors: Yamakawa
authors: Shigeichi
authors: S
authors: Shoji
authors: Yoshiki
authors: Y
authors: Nishizawa
authors: Masaaki
authors: M
authors: Inaba
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000368:Aged; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002118:Calcium / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010710:Phosphates / Q000097:blood; D006435:Renal Dialysis; D013851:Thinness / Q000503:physiopathology*
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D002118:Calcium