title: Implantation of resorbable gentamicin sponges in addition to irrigation and debridement in 34 patients with infection complicating total hip arthroplasty.
abstract: We evaluated a prosthesis-retaining treatment protocol for prosthetic joint infection in patients presenting at a mean of 116 days (range 10-1216 days) after primary arthroplasty. Our regime involved irrigation and debridement followed by implantation of biodegradable gentamicin loaded sponges which do not require removal after implantation. Of 34 patients with a deep infection after total hip arthroplasty, Twenty-five were treated successfully, with a mean follow-up of 35 months. There were no permanent complications. This success rate is comparable to earlier studies. Early initiation of treatment demonstrated a tendency for better results, and late chronic infections had a worse outcome. Because the sponges are degradable, a number of further surgical procedures were avoided.
authors: Department of Orthopaedics, Spaarne Hospital, Spaarnepoort 1, Hoofddorp, The Netherlands. jwp.kuiper@gmail.com
authors: Jesse W P
authors: JW
authors: Kuiper
authors: Richard M
authors: RM
authors: Brohet
authors: Sander
authors: S
authors: Wassink
authors: Michel P J
authors: MP
authors: van den Bekerom
authors: Petrus A
authors: PA
authors: Nolte
authors: Diederik A
authors: DA
authors: Vergroesen
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D003646:Debridement; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D015503:Surgical Sponges; D007507:Therapeutic Irrigation; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins