title: Screening test for malignant hyperthermia in patients with persistent hyperCKemia: a pilot study.
abstract: BACKGROUND
  Persistently elevated serum creatine kinase (CK) is frequently associated with predisposition to malignant hyperthermia (MH). We investigated whether a minimally invasive metabolic test is suitable to diagnose MH susceptibility among patients with hyperCKemia.
  
  
  METHODS
  Thirty-nine participants were included: 10 were MH susceptible (MHS); 21 MH were non-susceptible (MHN); and 8 had MHN with persistent hyperCKemia >500 U/L. Microdialysis probes were inserted into the vastus lateralis muscle, and halothane or caffeine was injected via an attached microtubing catheter. Lactate concentrations in dialysis samples were measured spectrophotometrically.
  
  
  RESULTS
  Baseline lactate did not differ between the groups. After local application of halothane or caffeine, a significant lactate increase was detected only in the MHS group.
  
  
  CONCLUSIONS
  Test results were not influenced by hyperCKemia. To avoid risks and complications of a surgical muscle biopsy this microdialysis test might be a useful screening tool for MH susceptibility among patients with persistent CK elevation.
authors: Department of Anaesthesia and Critical Care, University of Wuerzburg, Oberduerrbacher Strasse 6, D-97080 Wuerzburg, Germany.
authors: Stephan
authors: S
authors: Johannsen
authors: Christina
authors: C
authors: Berberich
authors: Thomas
authors: T
authors: Metterlein
authors: Cosima
authors: C
authors: Roth
authors: Karlheinz
authors: K
authors: Reiners
authors: Norbert
authors: N
authors: Roewer
authors: Frank
authors: F
authors: Schuster
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000097:blood*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D008305:Malignant Hyperthermia / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D017551:Microdialysis; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*
chemical_list: D019344:Lactic Acid; D003402:Creatine Kinase