title: Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study.
abstract: The etiology of endometriosis is poorly understood, and few modifiable risk factors have been identified. Dairy foods and some nutrients can modulate inflammatory and immune factors, which are altered in women with endometriosis. We investigated whether intake of dairy foods, nutrients concentrated in dairy foods, and predicted plasma 25-hydroxyvitamin D (25(OH)D) levels were associated with incident laparoscopically confirmed endometriosis among 70,556 US women in Nurses' Health Study II. Diet was assessed via food frequency questionnaire. A score for predicted 25(OH)D level was calculated for each participant. During 737,712 person-years of follow-up over a 14-year period (1991-2005), 1,385 cases of incident laparoscopically confirmed endometriosis were reported. Intakes of total and low-fat dairy foods were associated with a lower risk of endometriosis. Women consuming more than 3 servings of total dairy foods per day were 18% less likely to be diagnosed with endometriosis than those reporting 2 servings per day (rate ratio = 0.82, 95% confidence interval: 0.71, 0.95; P(trend) = 0.03). In addition, predicted plasma 25(OH)D level was inversely associated with endometriosis. Women in the highest quintile of predicted vitamin D level had a 24% lower risk of endometriosis than women in the lowest quintile (rate ratio = 0.76, 95% confidence interval: 0.60, 0.97; P(trend) = 0.004). Our findings suggest that greater predicted plasma 25(OH)D levels and higher intake of dairy foods are associated with a decreased risk of endometriosis.
authors: Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA 02115, USA. hharris3@partners.org
authors: Holly R
authors: HR
authors: Harris
authors: Jorge E
authors: JE
authors: Chavarro
authors: Susan
authors: S
authors: Malspeis
authors: Walter C
authors: WC
authors: Willett
authors: Stacey A
authors: SA
authors: Missmer
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002136:Calcium, Dietary / Q000378:metabolism*; D015331:Cohort Studies; D003611:Dairy Products; D004032:Diet; D004034:Diet Surveys; D004715:Endometriosis / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D008875:Middle Aged; D010298:Parity / Q000502:physiology; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D012907:Smoking / Q000503:physiopathology; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014815:Vitamins / Q000097:blood*
chemical_list: D002136:Calcium, Dietary; D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D008274:Magnesium
references: Ann Clin Biochem. 1986 Nov;23 ( Pt 6):667-70
references: 3800293
references: Br J Nutr. 2012 Nov 28;108(10):1889-96
references: 22264926
references: J Clin Invest. 1992 Jun;89(6):1988-94
references: 1602005
references: Am J Clin Nutr. 2003 Feb;77(2):504-11
references: 12540414
references: J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):93-101
references: 16046118
references: Gastroenterology. 2012 Mar;142(3):482-9
references: 22155183
references: Int J Epidemiol. 1989 Dec;18(4):858-67
references: 2621022
references: Am J Epidemiol. 2004 Oct 15;160(8):784-96
references: 15466501
references: Obstet Gynecol Clin North Am. 1997 Jun;24(2):235-58
references: 9163765
references: Fertil Steril. 1998 Jul;70(1):81-8
references: 9660426
references: Am J Epidemiol. 1988 Jan;127(1):188-99
references: 3337073
references: Fertil Steril. 2000 Jan;73(1):166-70
references: 10632434
references: Hum Reprod. 2007 Aug;22(8):2273-8
references: 17548365
references: Ann Rheum Dis. 2007 Sep;66(9):1137-42
references: 17557889
references: J Natl Cancer Inst. 2006 Apr 5;98(7):451-9
references: 16595781
references: Br J Cancer. 2010 Apr 27;102(9):1422-7
references: 20389298
references: Endocrinology. 2006 Mar;147(3):1278-86
references: 16306083
references: J Nutr. 2008 Jun;138(6):1047-52
references: 18492832
references: Fertil Steril. 1996 May;65(5):925-30
references: 8612850
references: Am J Reprod Immunol. 1994 Oct;32(3):180-3
references: 7880401
references: Fertil Steril. 2001 Jan;75(1):1-10
references: 11163805
references: J Immunol. 2001 Nov 1;167(9):4974-80
references: 11673504
references: Am J Epidemiol. 1999 Mar 15;149(6):531-40
references: 10084242
references: Fertil Steril. 2001 Aug;76(2):223-31
references: 11476764
references: Hum Reprod. 2004 Aug;19(8):1755-9
references: 15254009
references: Obstet Gynecol Clin North Am. 2003 Mar;30(1):1-19, vii
references: 12699255
references: Sci Total Environ. 1990 Dec 1;99(1-2):67-76
references: 2270473
references: Gynecol Endocrinol. 2004 Jul;19(1):51-5
references: 15625774
references: Acta Obstet Gynecol Scand Suppl. 1994;159:7-14
references: 8209672
references: Br J Cancer. 2009 Sep 15;101(6):916-23
references: 19690551
references: Am J Epidemiol. 1985 Jul;122(1):51-65
references: 4014201
references: Br J Nutr. 2011 Feb;105(3):459-67
references: 20875189
references: Br J Pharmacol. 1987 Jul;91(3):449-51
references: 3496933
references: J Nutr. 2009 Mar;139(3):547-54
references: 19141703
references: Am J Epidemiol. 1992 May 15;135(10):1114-26; discussion 1127-36
references: 1632423
references: Fertil Steril. 2002 May;77(5):989-94
references: 12009356
references: Diabetes Care. 2010 Feb;33(2):304-10
references: 19903755
references: Scand J Clin Lab Invest. 1990 Apr;50(2):115-21
references: 2339276
references: Reprod Sci. 2007 Jul;14(5):486-97
references: 17913968
references: JAMA. 1997 Oct 1;278(13):1078-83
references: 9315766
references: J Reprod Med. 1987 Mar;32(3):194-7
references: 3494842
references: Fertil Steril. 1988 Aug;50(2):216-22
references: 3294043