title: pH-responsive dual cargo delivery from mesoporous silica nanoparticles with a metal-latched nanogate.
abstract: A nanogate composed of two iminodiacetic acid (IDA) molecules and a metal ion latch was designed, synthesized, and assembled on mesoporous silica nanoparticles. This gating mechanism is capable of storing and releasing metal ions and molecules trapped in the pores. Pore openings derivatized with IDA can be latched shut by forming a bis-IDA chelate complex with a metal ion. This system was tested by loading with Hoechst 33342 as the probe cargo molecule, and latching with cobalt, nickel, or calcium metal ions. No cargo release was observed in a neutral aqueous environment, but both cargoes were delivered after acid stimulation and/or the addition of a competitively binding ligand.
authors: Department of Chemistry and Biochemistry, California NanoSystems Institute, University of California, Los Angeles, California 90095, United States.
authors: Derrick
authors: D
authors: Tarn
authors: Min
authors: M
authors: Xue
authors: Jeffrey I
authors: JI
authors: Zink
mesh_terms: D002118:Calcium / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007098:Imino Acids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D007098:Imino Acids; D003035:Cobalt; D012822:Silicon Dioxide; D009532:Nickel; D002118:Calcium; C008109:iminodiacetic acid
references: J Am Chem Soc. 2010 Aug 11;132(31):10623-5
references: 20681678
references: Small. 2007 Aug;3(8):1341-6
references: 17566138
references: Nature. 2002 Jun 20;417(6891):813-21
references: 12075343
references: J Am Chem Soc. 2009 Feb 11;131(5):1686-8
references: 19159224
references: Acc Chem Res. 2007 Sep;40(9):846-53
references: 17645305
references: Small. 2008 Apr;4(4):421-6
references: 18383576
references: J Am Chem Soc. 2008 Feb 27;130(8):2382-3
references: 18232687
references: Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10029-34
references: 16006520
references: Chem Soc Rev. 2012 Apr 7;41(7):2590-605
references: 22216418
references: Dalton Trans. 2012 Apr 28;41(16):5038-44
references: 22378252
references: J Phys Chem C Nanomater Interfaces. 2011 Oct 13;115(40):19496-19506
references: 23667713
references: Small. 2010 Sep 20;6(18):1952-67
references: 20690133
references: Nat Cell Biol. 2003 Dec;5(12):1041-3
references: 14647298
references: Adv Drug Deliv Rev. 2008 Aug 17;60(11):1278-88
references: 18514969
references: Nat Nanotechnol. 2006 Oct;1(1):25-35
references: 18654138
references: Angew Chem Int Ed Engl. 2010 Sep 24;49(40):7281-3
references: 20737526
references: Inorg Chem Commun. 2009 Apr 1;12(4):312-315
references: 22068901
references: Nanoscale. 2009 Oct;1(1):16-39
references: 20644858
references: J Am Chem Soc. 2010 Sep 22;132(37):13016-25
references: 20799689
references: J Phys Chem Lett. 2012 Feb 2;3(3):364-74
references: 26285853
references: Nat Rev Mol Cell Biol. 2003 Jul;4(7):530-8
references: 12838336
references: J Am Chem Soc. 2010 Sep 15;132(36):12690-7
references: 20718462
references: Oncogene. 2003 Nov 24;22(53):8619-27
references: 14634623
references: Environ Sci Technol. 2010 Aug 15;44(16):6390-5
references: 20608701
references: Acc Chem Res. 2008 Dec;41(12):1630-40
references: 18698851
references: Nat Rev Mol Cell Biol. 2003 Jul;4(7):552-65
references: 12838338
references: Crit Rev Oncol Hematol. 2002 Apr;42(1):35-56
references: 11923067
references: Acc Chem Res. 2011 Oct 18;44(10):903-13
references: 21675720
references: Nature. 2003 Jan 23;421(6921):350-3
references: 12540896