title: Transcatheter aortic valve replacement: history and current status.
abstract: Despite the poor prognosis associated with severe, symptomatic aortic stenosis, treatment options were limited for a large subgroup of patients deemed high risk for surgical replacement. The introduction of transcatheter aortic valve replacement (TAVR) over the past 10 years marks a new and exciting era in the treatment of valvular disease in these high-risk and inoperable patients. In this review, we outline the historical development, key clinical trials, current outcomes and future directions of TAVR.
authors: Department of Cardiology, Brigham and Women's Hospital, 75 Francis Street Boston, MA 02115, USA.
authors: Erin A
authors: EA
authors: Bohula May
authors: David
authors: D
authors: Faxon
mesh_terms: D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000266:history / Q000628:therapy*; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000266:history / Q000295:instrumentation / Q000639:trends; D005544:Forecasting; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000266:history / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D018579:Patient Selection; D011474:Prosthesis Design; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome