title: Mean platelet volume as a potential predictor of renovascular thrombosis after renal transplant.
abstract: OBJECTIVE
  We sought to evaluate the importance of mean platelet volume as a marker to follow-up, the tendency for hemorrhagic diatheses, and/or thrombotic complications in patients before and after renal transplant.
  
  
  METHODS
  Thirty-four patients (aged, 5 to 18 y) were included. Demographics of the patients, cause of chronic renal failure, dialysis modality, duration of dialysis, arterio-venous fistula thrombosis, and posttransplant immunosuppressive regimens were recorded and laboratory variables were evaluated.
  
  
  RESULTS
  At the end of the first posttransplant month, mean platelet volume level was decreased significantly when compared with pretransplant levels (8.3 ± 1.5 vs 7.7 ± 0.9; P = .04). A significant increase was observed in platelet levels during posttransplant measures (273.750 ± 97.700 vs 318.740 ± 84.586; P = .02). Prothrombin time and partial thromboplastin time levels did not differ before and after transplant. None of the patients had any thrombotic events and/or renal allograft loss. A negative correlation was observed between mean platelet volume and C-reactive protein (r=-0.53). Mean platelet volume level was not found to be related to the cause of renal failure, pretransplant dialysis modality, or posttransplant immunosuppressive regimens.
  
  
  CONCLUSIONS
  Platelet numbers increased and mean platelet volume decreased after pediatric renal transplant, but the potential for increased thrombosis was not observed.
authors: Department of Pediatric Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey. hales1972@yahoo.com
authors: Hale
authors: H
authors: Sakallı
authors: Esra
authors: E
authors: Baskın
authors: Umut Selda
authors: US
authors: Bayrakçı
authors: Kaan Savaş
authors: KS
authors: Gülleroğlu
authors: Gökhan
authors: G
authors: Moray
authors: Mehmet
authors: M
authors: Haberal
mesh_terms: D000293:Adolescent; D001792:Blood Platelets / Q000166:cytology*; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000453:epidemiology*; D016030:Kidney Transplantation; D008137:Longitudinal Studies; D008297:Male; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood / Q000453:epidemiology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000097:blood / Q000601:surgery; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood / Q000453:epidemiology*
chemical_list: D002097:C-Reactive Protein