title: Evaluation of the taurine concentrations in dog plasma and aqueous humour: a pilot study.
abstract: In the 70s, the amino acid taurine was found essential for photoreceptor survival. Recently, we found that taurine depletion can also trigger retinal ganglion cell degeneration both in vitro and in vivo. Therefore, evaluation of taurine levels could be a crucial biomarker for different pathologies of retinal ganglion cells such as glaucoma. Because different breeds of dog can develop glaucoma, we performed taurine measurements on plasma and aqueous humour samples from pet dogs. Here, we exposed results from a pilot study on normal selected breed of pet dogs, without any ocular pathology. Samples were collected by veterinarians who belong to the Réseau Européen d'Ophtalmologie Vétérinaire et de Vision Animale. Following measurements by high-performance liquid chromatography (HPLC), the averaged taurine concentration was 162.3 μM in the plasma and 51.8 μM in the aqueous humour. No correlation was observed between these two taurine concentrations, which exhibited a ratio close to 3. Further studies will determine if these taurine concentrations are changed in glaucomatous dogs.
authors: Réseau Européen d'Ophtalmologie Vétérinaire et de Vision Animale, Asnières, France. sg.rosolen@orange.fr
authors: Serge-George
authors: SG
authors: Rosolen
authors: Nathalie
authors: N
authors: Neveux
authors: José-Alain
authors: JA
authors: Sahel
authors: Serge
authors: S
authors: Picaud
authors: Nicolas
authors: N
authors: Froger
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D001947:Breeding; D003553:Cystine / Q000097:blood; D004032:Diet; D004285:Dogs / Q000097:blood*; D005260:Female; D006262:Health; D008297:Male; D008715:Methionine / Q000097:blood; D010865:Pilot Projects; D013654:Taurine / Q000096:biosynthesis / Q000097:blood*
chemical_list: D013654:Taurine; D003553:Cystine; D008715:Methionine