title: Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.
abstract: Much information is available for the 2009 H1N1 influenza immunity response, but little is known about the antibody change in seasonal influenza before and during the novel influenza A pandemic. In this study, we conducted a cross-sectional serological survey of 4 types of major seasonal influenza in March and September 2009 on a full range of age groups, to investigate seasonal influenza immunity response before and during the outbreak of the sH1N1 influenza in Shenzhen - the largest migration city in China. We found that the 0-5 age group had an increased antibody level for all types of seasonal influenza during the pandemic compared to the pre-outbreak level, in contrast with almost all other age groups, in which the antibody level decreased. Also, distinct from the antibodies of A/H3N2, B/Yamagata and B/Victoria that decreased significantly during the 2009 H1N1 pandemic, the antibody of A/H1N1 showed no statistical difference from the pre-outbreak level. The results suggest that the antibodies against the 2009 sH1N1 cross-reacted with seasonal H1N1. Moreover, the 0-5 age group was under attack by both seasonal and 2009 H1N1 influenza during the pandemic, hence vaccination merely against a new strain of flu might not be enough to protect the youngest group.
authors: The Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors: Chun-Li
authors: CL
authors: Wu
authors: Juan
authors: J
authors: Lu
authors: Maggie Haitian
authors: MH
authors: Wang
authors: Xing
authors: X
authors: Lv
authors: Ying
authors: Y
authors: Chen
authors: Hsiang-fu
authors: HF
authors: Kung
authors: Benny
authors: B
authors: Zee
authors: Xiao-wen
authors: XW
authors: Cheng
authors: Ming-Liang
authors: ML
authors: He
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000276:immunology / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D002681:China; D003429:Cross Reactions / Q000276:immunology; D003430:Cross-Sectional Studies; D004196:Disease Outbreaks; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology* / Q000472:pathogenicity; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology / Q000472:pathogenicity; D007251:Influenza, Human / Q000276:immunology* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D058873:Pandemics
chemical_list: D000914:Antibodies, Viral
references: J Clin Microbiol. 2000 Apr;38(4):1552-8
references: 10747142
references: N Engl J Med. 2009 Nov 12;361(20):1945-52
references: 19745214
references: PLoS One. 2010 Jul 14;5(7):e11601
references: 20644650
references: Science. 2009 Jul 10;325(5937):197-201
references: 19465683
references: Euro Surveill. 2009 Jun 04;14(22):
references: 19497256
references: Clin Microbiol Infect. 2011 May;17(5):732-7
references: 20731679
references: Biol Sex Differ. 2010 Nov 04;1(1):5
references: 21208468
references: J Clin Invest. 2010 May;120(5):1663-73
references: 20389023
references: J Med Virol. 2008 Jun;80(6):1058-64
references: 18428128
references: JAMA. 2009 Nov 4;302(17):1880-7
references: 19822626
references: N Engl J Med. 2009 Aug 13;361(7):674-9
references: 19564633
references: J Med Virol. 2010 Nov;82(11):1809-15
references: 20872705
references: Emerg Infect Dis. 2010 Mar;16(3):538-41
references: 20202441
references: Nature. 2009 Jun 18;459(7249):931-9
references: 19525932
references: N Engl J Med. 2009 Jun 18;360(25):2605-15
references: 19423869
references: Lancet. 2010 Mar 27;375(9720):1100-8
references: 20096450
references: J Virol. 2010 Jul;84(13):6527-35
references: 20410263
references: Epidemiol Infect. 2012 May;140(5):788-97
references: 21745428
references: Epidemiol Infect. 2011 Jan;139(1):52-8
references: 20854713
references: PLoS Curr. 2010 Feb 24;2:RRN1148
references: 20191082
references: Vaccine. 2006 Nov 10;24(44-46):6645-6
references: 16797802
references: N Engl J Med. 2009 Dec 17;361(25):2414-23
references: 19846844
references: PLoS Med. 2009 Nov;6(11):e1000168
references: 19918363
references: PLoS One. 2011;6(8):e23034
references: 21853064
references: Emerg Infect Dis. 2002 Aug;8(8):814-9
references: 12141967
references: Avian Dis. 1978 Apr-Jun;22(2):362-5
references: 678239
references: N Engl J Med. 2009 Jul 16;361(3):279-85
references: 19564632