title: Tissue factor non-coagulant signaling - molecular mechanisms and biological consequences with a focus on cell migration and apoptosis.
abstract: Tissue factor (TF), a transmembrane glycoprotein, is the main initiator of the blood coagulation cascade. TF is also recognized as a true signaling receptor. There is accumulating evidence that the downstream signaling effects of the TF complexes are transduced by several mechanisms, including: activation of protease-activated receptor (PAR)-1 and PAR-2, and the PAR-dependent pathways, via the TF cytoplasmic domain and by transactivation of receptor tyrosine kinases. Triggering of signaling cascades such as the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways couples TF to a multitude of functions within the cell, such as proliferation, cell migration, and survival. Thus, TF has a Janus face; on the one hand, it has vital life-maintaining functions, and on the other it has harmful effects, exemplified by inflammation, the acute coronary syndromes, and cancer. TF mediates a broad spectrum of signaling mechanisms. Learning more about these different mechanisms/pathways will lead to new treatment strategies, which can ultimately be personalized.
authors: Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden. mikael.aberg@medsci.uu.se
authors: M
authors: M
authors: Åberg
authors: A
authors: A
authors: Siegbahn
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction; D013925:Thromboplastin / Q000378:metabolism* / Q000502:physiology
chemical_list: D013925:Thromboplastin