title: Defining a direction: electron transfer and catalysis in Escherichia coli complex II enzymes.
abstract: There are two homologous membrane-bound enzymes in Escherichia coli that catalyze reversible conversion between succinate/fumarate and quinone/quinol. Succinate:ubiquinone reductase (SQR) is a component of aerobic respiratory chains, whereas quinol:fumarate reductase (QFR) utilizes menaquinol to reduce fumarate in a final step of anaerobic respiration. Although, both protein complexes are capable of supporting bacterial growth on either minimal succinate or fumarate media, the enzymes are more proficient in their physiological directions. Here we evaluate factors that may underlie this catalytic bias. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease.
authors: Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA. elena.maklashina@ucsf.edu
authors: Elena
authors: E
authors: Maklashina
authors: Gary
authors: G
authors: Cecchini
authors: Sergei A
authors: SA
authors: Dikanov
mesh_terms: D055162:Biocatalysis; D004579:Electron Transport; D042963:Electron Transport Complex II / Q000737:chemistry / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism*; D005650:Fumarates / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D010088:Oxidoreductases / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011809:Quinones / Q000737:chemistry / Q000378:metabolism; D019802:Succinic Acid / Q000737:chemistry / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; D005650:Fumarates; D011809:Quinones; C478189:respiratory complex II; D019802:Succinic Acid; D010088:Oxidoreductases; D042963:Electron Transport Complex II; C424907:quinol fumarate reductase
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