title: Artemisia iwayomogi Extract Attenuates High-Fat Diet-Induced Obesity by Decreasing the Expression of Genes Associated with Adipogenesis in Mice.
abstract: The objective of the present study was to determine whether Artemisia iwayomogi (AI) extract reduces visceral fat accumulation and obesity-related biomarkers in mice fed a high-fat diet (HFD), and if so, whether these effects are exerted by modulation of the expression of genes associated with adipogenesis and inflammation. AI extract supplementation for 11 weeks significantly prevented HFD-induced increments in body weight, visceral adiposity, adipocyte hypertrophy, and plasma levels of lipids and leptin. Additionally, AI extract supplementation resulted in downregulation of adipogenic transcription factors (PPARγ2 and C/EBPα) and their target genes (CD36, aP2, and FAS) in epididymal adipose tissue compared to the HFD alone. The AI extract effectively reversed the HFD-induced elevations in plasma glucose and insulin levels and the homeostasis model assessment of insulin resistance index. Furthermore, the extract significantly decreased gene expression of proinflammatory cytokines (TNFα, MCP1, IL-6, IFNα, and INFβ) in epididymal adipose tissue and reduced plasma levels of TNFα and MCP1 as compared to HFD alone. In conclusion, these results suggest that AI extract may prevent HFD-induced obesity and metabolic disorders, probably by downregulating the expression of genes related to adipogenesis and inflammation in visceral adipose tissue.
authors: Department of Food and Nutrition, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
authors: Yeji
authors: Y
authors: Choi
authors: Yasuko
authors: Y
authors: Yanagawa
authors: Sungun
authors: S
authors: Kim
authors: Wan Kyunn
authors: WK
authors: Whang
authors: Taesun
authors: T
authors: Park
references: Stem Cells. 1996;14 Suppl 1:154-62
references: 11012216
references: Nat Med. 1995 Nov;1(11):1155-61
references: 7584987
references: J Biol Chem. 2000 Oct 20;275(42):32523-9
references: 10913136
references: Cell. 1998 Apr 17;93(2):241-52
references: 9568716
references: Hepatology. 1990 Nov;12(5):1179-86
references: 1699862
references: Phytother Res. 2012 May;26(5):633-8
references: 21972114
references: Lipids Health Dis. 2012 Oct 02;11:126
references: 23031584
references: Planta Med. 2003 Dec;69(12):1159-62
references: 14750037
references: PLoS One. 2012;7(3):e33815
references: 22479450
references: Biol Pharm Bull. 2010;33(9):1610-4
references: 20823583
references: Diabetes. 2003 Nov;52(11):2784-9
references: 14578297
references: Planta Med. 2006 Aug;72(10):865-74
references: 16902852
references: J Biol Chem. 1993 Dec 15;268(35):26055-8
references: 8253716
references: Food Chem Toxicol. 2012 Oct;50(10):3505-13
references: 22824087
references: Diabetes. 2002 May;51(5):1319-36
references: 11978627
references: J Ethnopharmacol. 2012 Mar 6;140(1):179-85
references: 22265746
references: Diabetes Metab. 2000 May;26(3):178-82
references: 10880890
references: Int J Obes Relat Metab Disord. 2004 Aug;28(8):993-7
references: 15211360
references: J Biol Chem. 1957 May;226(1):497-509
references: 13428781
references: J Clin Invest. 2003 Dec;112(12):1821-30
references: 14679177
references: Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2062-8
references: 16123319
references: J Immunol. 1998 Jun 15;160(12):6032-8
references: 9637519
references: Science. 1993 Jan 1;259(5091):87-91
references: 7678183
references: Genes Dev. 1994 May 15;8(10):1224-34
references: 7926726
references: Diabetes. 1966 Dec;15(12):867-74
references: 5957477
references: Endocrinol Metab Clin North Am. 2008 Sep;37(3):635-46, viii-ix
references: 18775356
references: J Biol Chem. 2004 Jul 9;279(28):29558-64
references: 15123608
references: JAMA. 2002 Dec 4;288(21):2709-16
references: 12460094
references: J Clin Invest. 2001 Oct;108(7):1001-13
references: 11581301
references: Annu Rev Nutr. 1998;18:331-51
references: 9706228
references: Biochem Pharmacol. 2011 Jun 1;81(11):1343-51
references: 21439945
references: J Clin Invest. 2006 Jun;116(6):1494-505
references: 16691291
references: Science. 1996 Nov 15;274(5290):1185-8
references: 8895466
references: Mol Cell. 1999 Oct;4(4):597-609
references: 10549291
references: J Biol Chem. 2004 Aug 20;279(34):36093-102
references: 15190061
references: Exp Biol Med (Maywood). 2005 Jan;230(1):82-8
references: 15618130
references: Biotechnol Lett. 2005 Feb;27(4):253-7
references: 15742146
references: Mol Cell Biochem. 1998 Nov;188(1-2):33-9
references: 9823008
references: Biol Pharm Bull. 2005 May;28(5):921-4
references: 15863908
references: J Nutr Biochem. 2012 Feb;23(2):113-22
references: 21414767
references: Trends Endocrinol Metab. 2000 Aug;11(6):212-7
references: 10878750
references: Eur J Endocrinol. 2010 Aug;163(2):243-9
references: 20511357
references: Phytother Res. 2004 Jan;18(1):1-7
references: 14750192
references: Annu Rev Nutr. 2000;20:535-59
references: 10940345
references: J Biol Chem. 2006 Sep 8;281(36):26602-14
references: 16809344
references: Science. 1995 Aug 25;269(5227):1108-12
references: 7652557
references: Endocrinology. 2004 May;145(5):2273-82
references: 14726444
references: Biol Pharm Bull. 2010;33(8):1448-53
references: 20686247