title: [Secretion of melatonin and serum cholinesterase activity as biological markers of cognitive disorders in the acute stage of ischemic stroke].
abstract: The content of 6-sulfatoximelatonin in daily urine and butyrylcholinesterase in blood serum was determined in the acute stage of ischemic stroke in 25 and 40 men, respectively. Correlations between these parameters and the cognitive state of patients were analyzed. The decrease in the 6-sulfatoximelatonin excretion and butyrylcholinesterase activity was identified. The level of 6-sulfatoximelatonin in daily urine lower than 4.0 ng/ml may be considered as a biological marker of cognitive impairment with marked memory impairment. The level of butyrylcholinesterase lower than 7.0 nmol/L may be a biochemical marker of multifunctional cognitive impairment.
authors: A A
authors: AA
authors: Kulesh
authors: V V
authors: VV
authors: Shestakov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002091:Butyrylcholinesterase / Q000097:blood*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine; D008875:Middle Aged; D020521:Stroke / Q000150:complications*
chemical_list: D015415:Biomarkers; C054513:6-sulfatoxymelatonin; D002091:Butyrylcholinesterase; D008550:Melatonin