title: Fetoscopic laser therapy for twin-to-twin transfusion syndrome.
abstract: Twin-to-twin transfusion syndrome (TTTS) is a unique and complicated phenomenon occurring in 10-15% of monochorionic gestations. The chronic unbalanced distribution of blood volume across placental anastomoses between the donor and recipient fetuses leads to multisystem organ impairment including maladaptive changes in both fetuses. Fetoscopic selective laser photocoagulation (SLPC) is now established as the primary treatment modality for advanced stages of TTTS. SLPC is also associated with a risk reduction in fetal demise and long-term neurological impairment.
authors: The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. khalekn@email.chop.edu
authors: Nahla
authors: N
authors: Khalek
authors: Mark P
authors: MP
authors: Johnson
authors: Michael W
authors: MW
authors: Bebbington
mesh_terms: D002547:Cerebral Palsy / Q000209:etiology / Q000517:prevention & control; D002658:Developmental Disabilities / Q000209:etiology / Q000517:prevention & control; D005260:Female; D005330:Fetofetal Transfusion / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D005332:Fetoscopy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D017075:Laser Coagulation / Q000009:adverse effects / Q000379:methods*; D010920:Placenta / Q000002:abnormalities / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D011247:Pregnancy; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal