title: A web-based tool for personalized prediction of long-term disease course in patients with multiple sclerosis.
abstract: OBJECTIVE
  The Evidence-Based Decision Support Tool in Multiple Sclerosis (EBDiMS) is the first web-based prognostic calculator in multiple sclerosis (MS) capable of delivering individualized estimates of disease progression. It has recently been extended to provide long-term predictions based on the data from a large natural history cohort.
  
  
  METHODS
  We compared the predictive accuracy and consistency of EBDiMS with that of 17 neurologists highly specialized in MS.
  
  
  RESULTS
  We show that whilst the predictive accuracy was similar, neurologists showed a significant intra-rater and inter-rater variability.
  
  
  CONCLUSIONS
  Because EBDiMS was consistent, it is of superior utility in a specialist setting. Further field testing of EBDiMS in non-specialist settings, and investigation of its usefulness for counselling patients in treatment decisions, is warranted.
authors: University of Southampton, Southampton, UK. I.Galea@soton.ac.uk
authors: I
authors: I
authors: Galea
authors: C
authors: C
authors: Lederer
authors: A
authors: A
authors: Neuhaus
authors: P A
authors: PA
authors: Muraro
authors: A
authors: A
authors: Scalfari
authors: N
authors: N
authors: Koch-Henriksen
authors: C
authors: C
authors: Heesen
authors: S
authors: S
authors: Koepke
authors: P
authors: P
authors: Stellmann
authors: H
authors: H
authors: Albrecht
authors: A
authors: A
authors: Winkelmann
authors: F
authors: F
authors: Weber
authors: E
authors: E
authors: Bahn
authors: M
authors: M
authors: Hauser
authors: G
authors: G
authors: Edan
authors: G
authors: G
authors: Ebers
authors: M
authors: M
authors: Daumer
mesh_terms: D020000:Decision Support Systems, Clinical / Q000295:instrumentation*; D006801:Humans; D020407:Internet; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009462:Neurology / Q000706:statistics & numerical data*; D015588:Observer Variation; D057285:Precision Medicine / Q000379:methods*; D011379:Prognosis; D013038:Specialization / Q000706:statistics & numerical data*
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