title: Analysis of pulsatile retinal movements by spectral-domain low-coherence interferometry: influence of age and glaucoma on the pulse wave.
abstract: Recent studies have shown that ocular hemodynamics and eye tissue biomechanical properties play an important role in the pathophysiology of glaucoma. Nevertheless, better, non-invasive methods to assess these characteristics in vivo are essential for a thorough understanding of degenerative mechanisms. Here, we propose to measure ocular tissue movements induced by cardiac pulsations and study the ocular pulse waveform as an indicator of tissue compliance. Using a novel, low-cost and non-invasive device based on spectral-domain low coherence interferometry (SD-LCI), we demonstrate the potential of this technique to differentiate ocular hemodynamic and biomechanical properties. We measured the axial movement of the retina driven by the pulsatile ocular blood flow in 11 young healthy individuals, 12 older healthy individuals and 15 older treated glaucoma patients using our custom-made SD-OCT apparatus. The cardiac pulse was simultaneously measured through the use of an oximeter to allow comparison. Spectral components up to the second harmonic were obtained and analyzed. For the different cohorts, we computed a few parameters that characterize the three groups of individuals by analyzing the movement of the retinal tissue at two locations, using this simple, low-cost interferometric device. Our pilot study indicates that spectral analysis of the fundus pulsation has potential for the study of ocular biomechanical and vascular properties, as well as for the study of ocular disease.
authors: Institut National de la Recherche Scientifique-Énergie, Matériaux et Télécommunications, Varennes, Québec, Canada.
authors: Carolyne
authors: C
authors: Dion
authors: Kanwarpal
authors: K
authors: Singh
authors: Tsuneyuki
authors: T
authors: Ozaki
authors: Mark R
authors: MR
authors: Lesk
authors: Santiago
authors: S
authors: Costantino
mesh_terms: D000328:Adult; D000368:Aged; D005123:Eye / Q000098:blood supply / Q000503:physiopathology*; D005133:Eye Movements / Q000502:physiology; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000503:physiopathology*; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009799:Ocular Physiological Phenomena; D012039:Regional Blood Flow / Q000502:physiology; D012160:Retina / Q000503:physiopathology*; D014065:Tonometry, Ocular / Q000295:instrumentation / Q000379:methods; D055815:Young Adult
references: Eye (Lond). 1997;11 ( Pt 4):485-8
references: 9425412
references: Am J Ophthalmol. 1998 Jul;126(1):42-51
references: 9683148
references: J Cereb Blood Flow Metab. 1998 Mar;18(3):311-8
references: 9498848
references: Surv Ophthalmol. 1994 May;38 Suppl:S72-80
references: 7940150
references: Opt Express. 2009 Jul 6;17(14):11335-49
references: 19582048
references: J Opt Soc Am A Opt Image Sci Vis. 2007 May;24(5):1250-65
references: 17429471
references: Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3309-21
references: 11006219
references: Hypertension. 1988 Oct;12(4):380-7
references: 3169948
references: Kybernetik. 1971 Jun;8(6):207-14
references: 5090383
references: Acta Ophthalmol Scand. 1995 Oct;73(5):472-4
references: 8751134
references: IEEE Trans Biomed Eng. 2011 Mar;58(3):674-80
references: 21177153
references: J Cereb Blood Flow Metab. 1999 Apr;19(4):460-5
references: 10197516
references: Prog Retin Eye Res. 2002 Jul;21(4):359-93
references: 12150988
references: Exp Eye Res. 2010 Jul;91(1):63-8
references: 20398654
references: Eye (Lond). 2007 Sep;21(9):1212-9
references: 16936640
references: Invest Ophthalmol Vis Sci. 2012 Nov 27;53(12):7819-24
references: 23099495
references: Invest Ophthalmol Vis Sci. 2008 Sep;49(9):4046-50
references: 18487379
references: Graefes Arch Clin Exp Ophthalmol. 2002 Jun;240(6):475-80
references: 12107515
references: Arch Ophthalmol. 2006 Nov;124(11):1568-72
references: 17102003
references: Br J Ophthalmol. 1991 Aug;75(8):466-70
references: 1873264
references: Optom Vis Sci. 2008 Jun;85(6):425-35
references: 18521012
references: Circ Res. 1977 May;40(5):451-8
references: 856482
references: Vision Res. 1999 Jun;39(11):1911-5
references: 10343779
references: Isr Med Assoc J. 2001 Jun;3(6):443-8
references: 11433640
references: Stroke. 1993 Jan;24(1):6-9
references: 8418552
references: Invest Ophthalmol Vis Sci. 2011 Nov 21;52(12):8927-32
references: 21969303
references: J Biomed Opt. 2009 Sep-Oct;14(5):054047
references: 19895148
references: Acta Ophthalmol. 2009 Nov;87(8):901-5
references: 18937814