title: Relaxin: new pathophysiological aspects and pharmacological perspectives for an old protein.
abstract: Human relaxin-2 (hereafter simply defined as "relaxin") is a 6-kDa peptidic hormone best known for the physiological role played during pregnancy in the growth and differentiation of the reproductive tract and in the renal and systemic hemodynamic changes. This factor can also be involved in the pathophysiology of arterial hypertension and heart failure, in the molecular pathways of fibrosis and cancer, and in angiogenesis and bone remodeling. It belongs to the relaxin peptide family, whose members comprehensively exert numerous effects through interaction with different types of receptors, classified as relaxin family peptide (RXFP) receptors (RXFP1, RXFP2, RXFP3, RXFP4). Research looks toward the in-depth examination and complete understanding of relaxin in its various pleiotropic actions. The intent is to evaluate the likelihood of employing this substance for therapeutic purposes, for instance in diseases where a deficit could be part of the underlying pathophysiological mechanisms, also avoiding any adverse effect. Relaxin is already being considered as a promising drug, especially in acute heart failure. A careful study of the different RXFPs and their receptors and the comprehension of all biological activities of these hormones will probably provide new drugs with a potential wide range of therapeutic applications in the near future.
authors: Department of Internal Medicine, University of Messina, Via Consolare Valeria, 1, 98100, Italy.
authors: Valeria
authors: V
authors: Cernaro
authors: Antonio
authors: A
authors: Lacquaniti
authors: Rosaria
authors: R
authors: Lupica
authors: Antoine
authors: A
authors: Buemi
authors: Domenico
authors: D
authors: Trimboli
authors: Grazia
authors: G
authors: Giorgianni
authors: Davide
authors: D
authors: Bolignano
authors: Michele
authors: M
authors: Buemi
mesh_terms: D001826:Body Fluids / Q000502:physiology; D005260:Female; D006333:Heart Failure / Q000503:physiopathology; D006439:Hemodynamics; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007668:Kidney / Q000502:physiology; D008297:Male; D011247:Pregnancy; D012065:Relaxin / Q000494:pharmacology* / Q000502:physiology*
chemical_list: C095068:RLN2 protein, human; D012065:Relaxin
keywords: new drugs; pleiotropic hormone; relaxin; relaxin family peptide (RXFP) receptors