title: Comparing lidocaine, bupivacaine and a lidocaine-bupivacaine mixture as a metacarpal block in sheep.
abstract: Mechanical sensory blocking effects in the metacarpi of rams were compared following perineural injection of saline, 2% lidocaine (LIDO), 0.5% bupivacaine (BUPI), and a 1:1 (volume/volume) mixture of LIDO-BUPI. Saline was also administered in the contralateral metacarpi. Compared with the saline treatment and contralateral controls, the various treatments induced larger area under the curve (AUC) values 0-60 min post-treatment (AUC0-60). Administration of BUPI and LIDO-BUPI also induced larger AUC60-120 values (P<0.01). The AUC0-60 and AUC60-120 values with LIDO were less than those achieved with LIDO-BUPI and BUPI (P<0.001), and AUC60-120 values with LIDO-BUPI were less than those obtained with BUPI (P<0.05). Anaesthesia occurred within 5 min following the administration of all local anaesthetics and lasted longer in the case of BUPI (110.0 ± 47.3 min) than with LIDO (40.0 ± 13.2 min) (P<0.01). The duration of anaesthesia was 86.9 ± 66.0 min with the LIDO-BUPI combination. Thus this combination offered no apparent advantages over the use of BUPI alone.
authors: Department of Pathobiology, Ross University School of Veterinary Medicine, P.O. Box 334, Basseterre, Saint Kitts and Nevis. ilizarraga@rossvet.edu.kn
authors: Ignacio
authors: I
authors: Lizarraga
authors: Emily
authors: E
authors: Janovyak
authors: Thierry
authors: T
authors: Beths
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D019540:Area Under Curve; D002045:Bupivacaine / Q000008:administration & dosage / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008663:Metacarpus; D009407:Nerve Block / Q000662:veterinary*; D010146:Pain / Q000517:prevention & control / Q000662:veterinary; D010147:Pain Measurement / Q000662:veterinary; D012756:Sheep; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine; D002045:Bupivacaine
keywords: Bupivacaine; Lidocaine; Local anaesthesia; Peripheral nerve block; Sheep