title: Imaging characteristics of an unusual, high-grade angiocentric glioma: a case report and review of the literature.
abstract: Angiocentric gliomas have recently been reclassified as a separate central nervous system tumor. Few cases have been reported, and most of those correspond to slow-growing, low-grade neoplasms in very young pediatric patients. Here we describe magnetic resonance imaging findings (including diffusion imaging, spectroscopy and tractography) in an unusual higher-grade neoplasm with pathologic features suggestive of an angiocentric glioma in a 15-year-old male. The tumor had mild heterogeneous enhancement on magnetic resonance imaging, and a low apparent diffusion coefficient (9.9 × 10(-4) mm(2)s(-1)), consistent with an intermediate-to-high cellularity tumor. Spectroscopic imaging showed elevated choline/phosphocreatine and choline/N-acetyl aspartate ratios, suggesting an unusually aggressive tumor. We conclude that angiocentric glioma should not be excluded from consideration at primary diagnosis, particularly in teenaged patients nearing adulthood.
authors: Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
authors: Hector N
authors: HN
authors: Aguilar
authors: Ryan W
authors: RW
authors: Hung
authors: Vivek
authors: V
authors: Mehta
authors: Trevor
authors: T
authors: Kotylak
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D003389:Cranial Nerve Diseases / Q000209:etiology / Q000473:pathology*; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018303:Ganglioglioma / Q000175:diagnosis; D005729:Ganglioneuroma / Q000175:diagnosis; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis; D010211:Papilledema / Q000209:etiology / Q000473:pathology; D010291:Paresis / Q000209:etiology / Q000473:pathology; D000077204:Temozolomide; D016896:Treatment Outcome; D015354:Vision, Low
chemical_list: D003606:Dacarbazine; D000077204:Temozolomide
keywords: MR imaging; MR spectroscopy; MR tractography; angiocentric glioma; diffusion tensor imaging
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