title: The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA Study.
abstract: We assessed the interaction between the APOE ε4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE ε4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.
authors: CAPHRI, Department of Social Medicine, Maastricht University, Maastricht, The Netherlands. angelique.vermeiren@ggdzl.nl
authors: Angelique P A
authors: AP
authors: Vermeiren
authors: Hans
authors: H
authors: Bosma
authors: Pieter-Jelle
authors: PJ
authors: Visser
authors: Maurice P
authors: MP
authors: Zeegers
authors: Caroline
authors: C
authors: Graff
authors: Michael
authors: M
authors: Ewers
authors: Giovanni B
authors: GB
authors: Frisoni
authors: Lutz
authors: L
authors: Frölich
authors: Harald
authors: H
authors: Hampel
authors: Roy W
authors: RW
authors: Jones
authors: Patrick G
authors: PG
authors: Kehoe
authors: Hermine
authors: H
authors: Lenoir
authors: Lennart
authors: L
authors: Minthon
authors: Flavio M
authors: FM
authors: Nobili
authors: Marcel
authors: M
authors: Olde Rikkert
authors: Anne-Sophie
authors: AS
authors: Rigaud
authors: Philip
authors: P
authors: Scheltens
authors: Hilkka
authors: H
authors: Soininen
authors: Luiza
authors: L
authors: Spiru
authors: Magda
authors: M
authors: Tsolaki
authors: Lars-Olof
authors: LO
authors: Wahlund
authors: Bruno
authors: B
authors: Vellas
authors: Gordon
authors: G
authors: Wilcock
authors: Lyzel S
authors: LS
authors: Elias-Sonnenschein
authors: Frans R J
authors: FR
authors: Verhey
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D053327:Apolipoprotein E4 / Q000235:genetics*; D015331:Cohort Studies; D004247:DNA / Q000235:genetics; D004522:Educational Status; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008569:Memory Disorders / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012737:Sex Factors; D016019:Survival Analysis
chemical_list: D053327:Apolipoprotein E4; D004247:DNA