title: Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients in Southern China population.
abstract: BACKGROUND
  The connection between gut microbiota and metabolism and its role in the pathogenesis of diabetes are increasingly recognized. The objective of this study was to quantitatively measure Bifidobacterium and Lactobacillus species, members of commensal bacteria found in human gut, in type 2 diabetic patients (T2D) patients from Southern China.
  
  
  METHODS
  Fifty patients with T2D and thirty control individuals of similar body mass index (BMI) were recruited from Southern China. T2D and control subjects were confirmed with both oral glucose tolerance test (OGTT) and HbA(1c) measurements. Bifidobacterium and Lactobacillus species in feces were measured by real-time quantitative PCR. Data were analyzed with STATA 11.0 statistical software.
  
  
  RESULTS
  In comparison to control subjects T2D patients had significantly more total Lactobacillus (+18%), L. bugaricus (+13%), L. rhamnosum (+37%) and L. acidophilus (+48%) (P < 0.05). In contrast, T2D patients had less amounts of total Bifidobacteria (-7%) and B. adolescentis (-12%) (P < 0.05). Cluster analysis showed that gut microbiota pattern of T2D patients is characterized by greater numbers of L. rhamnosus and L. acidophillus, together with lesser numbers of B. adolescentis (P < 0.05).
  
  
  CONCLUSIONS
  The gut microflora in T2D patients is characterized by greater numbers of Lactobacillus and lesser numbers of Bifidobacterium species.
authors: International Center for Metabolic Diseases, Southern Medical University Guangzhou, China ; Nutrition and Health Department, Nestec Ltd., Nestlé Research Center Lausanne, Switzerland.
authors: Kim-Anne
authors: KA
authors: Lê
authors: Yan
authors: Y
authors: Li
authors: Xiaojing
authors: X
authors: Xu
authors: Wanting
authors: W
authors: Yang
authors: Tingting
authors: T
authors: Liu
authors: Xiaoning
authors: X
authors: Zhao
authors: Yongming Gorge
authors: YG
authors: Tang
authors: Dehong
authors: D
authors: Cai
authors: Vay Liang W
authors: VL
authors: Go
authors: Stephen
authors: S
authors: Pandol
authors: Hongxiang
authors: H
authors: Hui
keywords: gut; metabolic diseases; microbiota; microflora
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