title: Role of the gut microbiota in the development and function of lymphoid cells.
abstract: Mammals are colonized by large numbers of microorganisms, including trillions of bacteria, most of which live in the intestinal tract. These indigenous microorganisms that inhabit the body of humans and animals are referred collectively to as the microbiota. Accumulating evidence indicates that the microbiota regulates the development and/or function of different types of immune cells in the intestine. For example, the microbiota drives homeostatic, pathogenic, and regulatory T cell immune responses that contribute to tissue homeostasis, but also can promote disease. The gut microbes also facilitate IgA responses, which in turn regulate the composition and function of the gut microbiota. Thus, the reciprocal regulation of the gut microbiota and the host immune system may influence the balance between homeostasis and disease in the intestine.
authors: Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors: Nobuhiko
authors: N
authors: Kamada
authors: Gabriel
authors: G
authors: Núñez
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007410:Intestinal Diseases / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology* / Q000382:microbiology*; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000382:microbiology*
chemical_list: D007070:Immunoglobulin A
references: Infect Immun. 1999 Jul;67(7):3504-11
references: 10377132
references: Nature. 2008 Nov 27;456(7221):507-10
references: 18987631
references: Trends Immunol. 2012 Apr;33(4):160-7
references: 22410243
references: Nat Immunol. 2009 Jan;10(1):75-82
references: 19029904
references: Immunity. 2010 Jun 25;32(6):815-27
references: 20620945
references: Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8591-4
references: 8378333
references: Immunity. 2008 Dec 19;29(6):958-70
references: 19084435
references: Science. 2010 Oct 29;330(6004):665-9
references: 20929731
references: Immunity. 2008 Apr;28(4):546-58
references: 18387831
references: Nat Immunol. 2012 Oct;13(10):991-9
references: 22961052
references: J Immunol. 2011 Jul 15;187(2):733-47
references: 21666057
references: Immunity. 2002 Feb;16(2):219-30
references: 11869683
references: Nat Immunol. 2008 Jul;9(7):769-76
references: 18516037
references: Infect Immun. 1998 Nov;66(11):5224-31
references: 9784526
references: Nat Rev Immunol. 2010 Mar;10(3):159-69
references: 20182457
references: Immunity. 2010 Nov 24;33(5):736-51
references: 21093318
references: Cell Host Microbe. 2008 Oct 16;4(4):337-49
references: 18854238
references: Immunity. 2009 Oct 16;31(4):677-89
references: 19833089
references: J Immunol. 2011 Jun 1;186(11):6313-8
references: 21531892
references: Immunity. 2011 May 27;34(5):794-806
references: 21596591
references: Nat Immunol. 2011 Jan;12(1):21-7
references: 21113163
references: Science. 2006 Nov 17;314(5802):1157-60
references: 17110582
references: Int Immunol. 1993 Nov;5(11):1461-71
references: 7903159
references: Science. 2011 Oct 14;334(6053):255-8
references: 21998396
references: Nat Immunol. 2007 Oct;8(10):1086-94
references: 17873879
references: Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4615-22
references: 20660719
references: Cell. 2010 Mar 19;140(6):845-58
references: 20303875
references: Immunity. 2009 Jan 16;30(1):92-107
references: 19119024
references: Curr Opin Immunol. 2012 Jun;24(3):277-83
references: 22521138
references: J Exp Med. 2007 Aug 6;204(8):1775-85
references: 17620362
references: Nature. 2006 Mar 9;440(7081):228-32
references: 16407890
references: Immunity. 2004 Oct;21(4):527-38
references: 15485630
references: Science. 2012 Jun 8;336(6086):1321-5
references: 22674331
references: Nat Immunol. 2007 Dec;8(12):1390-7
references: 17994024
references: Nat Rev Immunol. 2011 Jun 17;11(7):445-56
references: 21681197
references: Annu Rev Immunol. 2012;30:759-95
references: 22224764
references: J Immunol. 2011 Feb 1;186(3):1531-7
references: 21178008
references: J Exp Med. 2010 Jun 7;207(6):1321-32
references: 20498021
references: J Exp Med. 1990 Jul 1;172(1):239-44
references: 2141628
references: Immunity. 2010 Jul 23;33(1):71-83
references: 20643338
references: J Exp Med. 2012 Jul 2;209(7):1241-53
references: 22753927
references: J Immunol. 2017 Feb 1;198(3):981-985
references: 28115586
references: Ann N Y Acad Sci. 2012 Jan;1247:97-116
references: 22260403
references: Proc Natl Acad Sci U S A. 2011 May 24;108(21):8743-8
references: 21555560
references: EMBO J. 2011 Jun 17;30(14):2934-47
references: 21685873
references: Cell. 2012 Jun 22;149(7):1578-93
references: 22726443
references: Gastroenterology. 2011 Sep;141(3):1014-23
references: 21699791
references: Inflamm Bowel Dis. 2007 Oct;13(10):1202-11
references: 17607724
references: Science. 2011 May 20;332(6032):974-7
references: 21512004
references: Science. 2011 Jan 21;331(6015):337-41
references: 21205640
references: J Exp Med. 2012 Feb 13;209(2):251-8
references: 22291094
references: Science. 2012 Apr 27;336(6080):489-93
references: 22442383
references: Nature. 2008 Oct 9;455(7214):808-12
references: 18716618
references: Nature. 2007 Aug 23;448(7156):929-33
references: 17713535
references: Nature. 2009 Feb 5;457(7230):722-5
references: 18978771
references: Cell Host Microbe. 2010 Feb 18;7(2):140-50
references: 20159619
references: Nat Immunol. 2007 Sep;8(9):931-41
references: 17694059
references: Science. 2007 Jul 13;317(5835):256-60
references: 17569825
references: J Immunol. 2002 Jan 1;168(1):57-64
references: 11751946
references: Cell Host Microbe. 2007 Nov 15;2(5):328-39
references: 18005754
references: Immunity. 2006 Dec;25(6):941-52
references: 17137799
references: Immunol Rev. 2012 Jan;245(1):177-88
references: 22168420
references: Gut. 2008 Dec;57(12):1682-9
references: 18653729
references: Science. 2002 Nov 15;298(5597):1424-7
references: 12434060
references: J Exp Med. 2007 Aug 6;204(8):1757-64
references: 17620361
references: Nat Immunol. 2012 May;13(5):449-56
references: 22484733
references: Nat Immunol. 2009 Jan;10(1):83-91
references: 19029903
references: Nat Immunol. 2011 Mar;12(3):264-70
references: 21258321
references: Cell. 2009 Oct 30;139(3):485-98
references: 19836068
references: Eur J Immunol. 1996 Apr;26(4):945-8
references: 8625993
references: Nat Immunol. 2011 Apr;12(4):320-6
references: 21336274
references: Nature. 2012 Apr 26;484(7395):514-8
references: 22466287