title: Cancer prevention by tocopherols and tea polyphenols.
abstract: Tocopherols (vitamin E) and tea polyphenols have been reported to have cancer preventive activities. Large-scale human trials with high doses of alpha-tocopherol, however, have produced disappointing results. This review presents data showing that - and -tocopherols inhibit colon, lung, mammary and prostate carcinogenesis in animal models, whereas -tocopherol is ineffective in animal and human studies. Possible mechanisms of action are discussed. A broad cancer preventive activity of green tea polyphenols has been demonstrated in animal models, and many mechanisms have been proposed. The cancer preventive activity of green tea in humans, however, has not been conclusively demonstrated and remains to be further investigated.
authors: Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States. Electronic address: csyang@pharmacy.rutgers.edu.
authors: Chung S
authors: CS
authors: Yang
authors: Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
authors: Guangxun
authors: G
authors: Li
authors: Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
authors: Zhihong
authors: Z
authors: Yang
authors: Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
authors: Fei
authors: F
authors: Guan
authors: Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
authors: Amber
authors: A
authors: Chen
authors: Department of Food and Nutrition, Chungbuk National University, 52 Naesudong-ro, Heungdeok-gu, Cheongju 361-763, South Korea.
authors: Jihyeung
authors: J
authors: Ju
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000517:prevention & control; D004195:Disease Models, Animal; D006801:Humans; D008175:Lung Neoplasms / Q000517:prevention & control; D008297:Male; D051379:Mice; D059808:Polyphenols / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000517:prevention & control; D013662:Tea / Q000737:chemistry; D024505:Tocopherols / Q000737:chemistry / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D016588:Anticarcinogenic Agents; D059808:Polyphenols; D013662:Tea; D014810:Vitamin E; D024505:Tocopherols
references: Prostate. 2009 May 1;69(6):644-51
references: 19143023
references: Clin Cancer Res. 2009 Jun 15;15(12):4242-9
references: 19509159
references: Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10350-5
references: 11504910
references: Cancer Res. 2006 Dec 1;66(23):11494-501
references: 17145898
references: Nutrients. 2011 Nov;3(11):962-86
references: 22254089
references: Carcinogenesis. 2010 Apr;31(4):533-42
references: 19748925
references: J Biol Chem. 2005 Apr 29;280(17):16882-90
references: 15713670
references: Cancer Prev Res (Phila). 2011 Sep;4(9):1366-77
references: 21750208
references: Cancers (Basel). 2011 Sep 28;3(4):3762-72
references: 24213110
references: Cancer Res. 1992 Apr 1;52(7):1943-7
references: 1551122
references: Carcinogenesis. 2010 Apr;31(4):687-94
references: 20097733
references: Cancer Prev Res (Phila). 2009 Feb;2(2):143-52
references: 19155443
references: Carcinogenesis. 1998 Jul;19(7):1269-73
references: 9683188
references: J Nutr. 2003 Oct;133(10):3303S-3309S
references: 14519830
references: Cancer Res. 2002 Dec 15;62(24):7241-6
references: 12499265
references: Mol Nutr Food Res. 2005 Jan;49(1):43-51
references: 15538715
references: J Natl Cancer Inst. 1994 Jun 1;86(11):855-8
references: 8182766
references: Pharmacol Res. 2011 Aug;64(2):87-99
references: 21371557
references: Clin Cancer Res. 2008 Aug 1;14(15):4981-8
references: 18676773
references: Mol Aspects Med. 2007 Oct-Dec;28(5-6):668-91
references: 17316780
references: Carcinogenesis. 2008 Jan;29(1):113-9
references: 17893236
references: Mol Cancer Ther. 2007 Jul;6(7):2022-8
references: 17620432
references: Pharmacol Res. 2011 Aug;64(2):123-35
references: 21419224
references: JAMA. 2009 Jan 7;301(1):52-62
references: 19066368
references: Cancer Prev Res (Phila). 2012 Apr;5(4):644-54
references: 22366914
references: Cancer Prev Res (Phila). 2012 May;5(5):701-5
references: 22490437
references: Ann Nutr Metab. 2004;48(3):169-88
references: 15256801
references: J Org Chem. 2007 Aug 17;72(17):6504-12
references: 17636958
references: Nat Struct Mol Biol. 2004 Apr;11(4):380-1
references: 15024383
references: Am J Clin Nutr. 2001 Dec;74(6):714-22
references: 11722951
references: J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23
references: 11121464
references: Toxicol Appl Pharmacol. 2007 Nov 1;224(3):209-13
references: 17188726
references: Int J Cancer. 2008 Sep 1;123(5):1173-80
references: 18546288
references: Int J Urol. 1999 Feb;6(2):93-9
references: 10226814
references: JAMA. 2009 Jan 7;301(1):39-51
references: 19066370
references: Int J Cancer. 2009 Apr 1;124(7):1693-9
references: 19115203
references: JAMA. 2005 Jul 6;294(1):56-65
references: 15998891
references: Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S139-51
references: 18551457
references: Cancer Prev Res (Phila). 2011 Mar;4(3):404-13
references: 21372040
references: Am J Epidemiol. 2003 Feb 15;157(4):335-44
references: 12578804
references: Cancer Res. 2005 Nov 15;65(22):10623-31
references: 16288056
references: Mol Nutr Food Res. 2009 Aug;53(8):1030-5
references: 19557822
references: Cancer Prev Res (Phila). 2008 Sep;1(4):298-304
references: 19138973
references: Jpn J Clin Oncol. 2012 Apr;42(4):335-46
references: 22371426
references: Cancer Res. 2004 Dec 1;64(23):8715-22
references: 15574782
references: J Natl Cancer Inst. 1993 Jul 7;85(13):1038-49
references: 8515490
references: Carcinogenesis. 2004 Nov;25(11):2217-24
references: 15358631
references: Int J Urol. 2003 Mar;10(3):160-6
references: 12622713
references: Cancer Res. 1998 Sep 15;58(18):4096-101
references: 9751618
references: Cancer Res. 2003 Dec 1;63(23):8118-21
references: 14678963
references: Nutr Cancer. 2003;46(2):172-8
references: 14690793
references: Free Radic Biol Med. 2004 Jan 1;36(1):1-15
references: 14732286
references: JAMA. 2011 Oct 12;306(14):1549-56
references: 21990298
references: Nutr Cancer. 2007;59(1):76-81
references: 17927505
references: Nat Rev Cancer. 2009 Jun;9(6):429-39
references: 19472429
references: Semin Cancer Biol. 2007 Oct;17(5):395-402
references: 17686632
references: Crit Rev Oncol Hematol. 2003 Sep;47(3):249-59
references: 12962899