title: [Stevens-Johnson syndrome concurrent with primary Epstein-Barr virus infection].
abstract: BACKGROUND
  Primary EBV infection mainly affects children and young adults. Most patients present the characteristic triad of fever, pharyngitis and lymphadenopathy. Symptoms may include a morbilliform eruption, occasionally induced by amoxicillin. We report a case of Stevens-Johnson syndrome concurrent with EBV infection.
  
  
  METHODS
  A 17-year-old boy consulted for an eruption suggestive of Stevens-Johnson syndrome, which was supported by the histopathology results. The patient had taken no medication during the previous weeks. Laboratory examinations showed atypical activated T lymphocytes. Serological tests and PCR results confirmed the diagnosis of primary EBV infection. The outcome was spontaneously favorable with only symptomatic treatment being required.
  
  
  CONCLUSIONS
  Stevens-Johnson syndrome is characterized by "target" lesions and profuse mucous membrane involvement. Stevens-Johnson syndrome is frequently drug-induced, being due less frequently to infections. Stevens-Johnson syndrome is very rarely a manifestation of infectious mononucleosis, with only one case being reported in the literature. When confronted with Stevens-Johnson syndrome without any imputable medication, complete screening for infection should be performed, in particular for primary EBV infection.
authors: Service de dermatologie, hôpital Bichat-Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
authors: F
authors: F
authors: Brunet-Possenti
authors: M
authors: M
authors: Steff
authors: E
authors: E
authors: Marinho
authors: B
authors: B
authors: Crickx
authors: V
authors: V
authors: Descamps
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications*; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D000914:Antibodies, Viral