title: Comparison of the distribution of dendritic cells in peri-implant mucosa and healthy gingiva.
abstract: OBJECTIVE
  The host response to infection differs between peri-implantitis and periodontitis, but the mechanisms underlying these differences are not understood. In this study, the distribution of dendritic cell subpopulations in healthy peri-implant mucosa (HPIM) was compared to that of healthy gingiva (HG).
  
  
  METHODS
  HPIM and HG specimens were obtained from nonsmoking, systemically healthy subjects. Immunohistochemistry was used to quantify the number of Langerhans cells (LCs) (CD1a+) and interstitial dendritic cells (IDCs) (factor XIIIa+) in the oral epithelium, sulcular/junctional epithelia, and lamina propria without inflammatory infiltration and with inflammatory infiltration.
  
  
  RESULTS
  Fourteen HPIM and 13 HG specimens were obtained from subjects aged 29 to 55 years. The lamina propria of the HPIM had fewer LCs than that of the HG (HPIM: 7.99 ± 10.76, HG: 25.68 ± 16.98; P = .003). There was no significant difference in the number of CD1a+ cells in the oral epithelium or the sulcular/junctional epithelia between the HPIM and the HG (P ≥ .23). A greater number of IDCs was observed in the lamina propria with inflammatory infiltration of the HPIM compared to the HG (HPIM: 57.02 ± 35.70, HG: 33.89 ± 26.98; P = .06).
  
  
  CONCLUSIONS
  In the lamina propria of HPIM, fewer LCs and more IDCs were observed. These differences may be associated with reduced stimulation of the innate and acquired immune responses initiated by LCs and the greater matrix remodeling of peri-implant tissue associated with IDCs.
authors: Department of Biotechnology and Bioscience, Federal University of Santa Catarina, Florianópolis, Brazil.
authors: Veronica Vargas
authors: VV
authors: Horewicz
authors: Luciana
authors: L
authors: Ramalho
authors: Jean Nunes
authors: JN
authors: dos Santos
authors: Eduardo
authors: E
authors: Ferrucio
authors: Patricia Ramos
authors: PR
authors: Cury
mesh_terms: D000328:Adult; D018949:Antigens, CD1 / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D002452:Cell Count; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D004846:Epithelial Attachment / Q000166:cytology* / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D026122:Factor XIIIa / Q000032:analysis; D005260:Female; D005881:Gingiva / Q000166:cytology* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000166:cytology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000166:cytology* / Q000276:immunology; D010518:Periodontitis / Q000276:immunology / Q000473:pathology
chemical_list: D018949:Antigens, CD1; D015415:Biomarkers; C419393:CD1a antigen; D026122:Factor XIIIa