title: Strain measurement of abdominal aortic aneurysm with real-time 3D ultrasound speckle tracking.
abstract: OBJECTIVE
  Abdominal aortic aneurysm rupture is caused by mechanical vascular tissue failure. Although mechanical properties within the aneurysm vary, currently available ultrasound methods assess only one cross-sectional segment of the aorta. This study aims to establish real-time 3-dimensional (3D) speckle tracking ultrasound to explore local displacement and strain parameters of the whole abdominal aortic aneurysm.
  
  
  METHODS
  Validation was performed on a silicone aneurysm model, perfused in a pulsatile artificial circulatory system. Wall motion of the silicone model was measured simultaneously with a commercial real-time 3D speckle tracking ultrasound system and either with laser-scan micrometry or with video photogrammetry. After validation, 3D ultrasound data were collected from abdominal aortic aneurysms of five patients and displacement and strain parameters were analysed.
  
  
  RESULTS
  Displacement parameters measured in vitro by 3D ultrasound and laser scan micrometer or video analysis were significantly correlated at pulse pressures between 40 and 80 mmHg. Strong local differences in displacement and strain were identified within the aortic aneurysms of patients.
  
  
  CONCLUSIONS
  Local wall strain of the whole abdominal aortic aneurysm can be analysed in vivo with real-time 3D ultrasound speckle tracking imaging, offering the prospect of individual non-invasive rupture risk analysis of abdominal aortic aneurysms.
authors: Department of Vascular and Endovascular Surgery, J.W. Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Peter.Bihari@kgu.de
authors: P
authors: P
authors: Bihari
authors: A
authors: A
authors: Shelke
authors: T H
authors: TH
authors: Nwe
authors: M
authors: M
authors: Mularczyk
authors: K
authors: K
authors: Nelson
authors: T
authors: T
authors: Schmandra
authors: P
authors: P
authors: Knez
authors: T
authors: T
authors: Schmitz-Rixen
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001019:Aortic Rupture / Q000209:etiology* / Q000503:physiopathology; D062186:Arterial Pressure; D001696:Biomechanical Phenomena; D006439:Hemodynamics; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D016014:Linear Models; D008297:Male; D019047:Phantoms, Imaging; D010780:Photogrammetry; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012828:Silicones; D013314:Stress, Mechanical; D018084:Ultrasonography, Interventional / Q000295:instrumentation; D014741:Video Recording
chemical_list: D012828:Silicones