title: P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region.
abstract: OBJECTIVE
  The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination.
  
  
  METHODS
  Sections made from two tissue arrays composed of 222 oral squamous cell carcinomas and 427 squamous cell carcinomas of the head and neck region, respectively, were examined for p53 expression and Ki-67 index by means of immunohistochemistry. Correlation of long-term clinical findings of the patients and pathological features of tumours with laboratory results were examined statistically.
  
  
  RESULTS
  No significant correlation was found between the p53 immunohistochemical expression in the 207 oral carcinomas and features of the tumours and patient outcomes. There was no significant association between the Ki-67 labelling index and the p53 expression.
  
  
  CONCLUSIONS
  Our failure in detecting any association of the p53 immunohistochemical expression regardless of HPV status with clinical features of these tumours suggests it lacks a prognostic value for squamous cell carcinomas of the oral cavity.
  
  
  CONCLUSIONS
  The prognostic value of p53 immunostaining in oral squamous carcinoma is not clarified yet. In the present study, there is no impact on any prognostical item nor even a correlation with cell proliferation (Ki-67) regardless of HPV status.
authors: Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246, Hamburg, Germany, a.groebe@uke.de.
authors: Alexander
authors: A
authors: Gröbe
authors: Henning
authors: H
authors: Hanken
authors: Ahmed
authors: A
authors: Al-Dam
authors: Georg
authors: G
authors: Cachovan
authors: Ralf
authors: R
authors: Smeets
authors: Antje
authors: A
authors: Krohn
authors: Till
authors: T
authors: Clauditz
authors: Tobias
authors: T
authors: Grob
authors: Ronald
authors: R
authors: Simon
authors: Guido
authors: G
authors: Sauter
authors: Lan
authors: L
authors: Kluwe
authors: Max
authors: M
authors: Heiland
authors: Marco
authors: M
authors: Blessmann
mesh_terms: D052685:Alphapapillomavirus / Q000302:isolation & purification; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D017931:DNA Primers; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D016133:Polymerase Chain Reaction; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D017931:DNA Primers; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
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