title: Early treatment with high-dose interferon beta-1a reverses cognitive and cortical plasticity deﬁcits in multiple sclerosis.
abstract: Acute inﬂammation is associated with cognitive deﬁcits and alterations of cortical plasticity in multiple sclerosis (MS). We tested whether early treatment with high-dose interferon (IFN) beta-1a, known to reduce inﬂammatory activity, improves cortical function and cognitive deﬁcits in MS. Eighty treatment-naïve relapsing-remitting MS (RRMS)patients received IFN beta-1a (44 mcg) subcutaneously three times per week. Cognitive performance and cortical plasticity were measured through the paced auditory serial addition test (PASAT) and intermittent theta burst stimulation (iTBS) before and up to two years af-ter IFN beta-1a initiation. Before treatment, patients with gadolinium-enhancing lesions (Gd+) on MRI performed worse on the PASAT,and showed lower iTBS-induced plasticity, compared with Gd- patients. Six months after treatment initiation both PASAT and iTBS-induced plasticity improved in Gd+ and remained stable in Gd- patients. These results suggest that cognitive and synaptic plasticity deﬁcits may be rescued during high-doseIFN beta-1a treatment in newly-diagnosed RRMS patients with Gd+ lesions.
authors: UOSD CSM, Clinica Neurologica, Policlinico Tor Vergata, Rome, Italy. francesco@virgillio
authors: Francesco
authors: F
authors: Mori
authors: Hajime
authors: H
authors: Kusayanagi
authors: Fabio
authors: F
authors: Buttari
authors: Barbara
authors: B
authors: Centini
authors: Fabrizia
authors: F
authors: Monteleone
authors: Carolina Gabri
authors: CG
authors: Nicoletti
authors: Giorgio
authors: G
authors: Bernardi
authors: Elisabetta Verdun
authors: EV
authors: Di Cantogno
authors: Maria Grazia
authors: MG
authors: Marciani
authors: Diego
authors: D
authors: Centonze
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005682:Gadolinium; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D007279:Injections, Subcutaneous; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000008:administration & dosage* / Q000627:therapeutic use; D007558:Italy; D008279:Magnetic Resonance Imaging; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology; D009483:Neuropsychological Tests; D055502:Secondary Prevention; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D055815:Young Adult
chemical_list: D000276:Adjuvants, Immunologic; D016899:Interferon-beta; D005682:Gadolinium; D000068556:Interferon beta-1a
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