title: Mismatch between transcriptomic and histopathologic picture of canine lymphomas.
abstract: Lymphoma is one of the most common malignant tumours occurring in dogs. Since there is a constant need for new, more comprehensive laboratory diagnostic tools which permit the precise determination of many tumour-related factors we decided to verify whether the use of microarray analysis could be helpful in classifying lymphomas. The study was performed on samples collected from 7 dogs in which multicentric lymphoma was recognized. Among this group we were able to identify one sub-cluster of transcriptionally similar tumours, which completely differed in terms of the histopathological examination. Among them there were one diffuse large B cell lymphoma, one diffuse macronucleolated medium-sized cell lymphoma and one pleomorphic mixed small and large T-cell lymphoma. The lymphomas belonging to the sub-cluster differed from other analysed tumours in the expression of more than 100 genes of which only 18 were described earlier in regard to lymphomas.
authors: Department of Small Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-787 Warsaw, Poland. magdalena.zmudzka@gmail.com
authors: M
authors: M
authors: Ostrzeszewicz
authors: H
authors: H
authors: Maciejewski
authors: R
authors: R
authors: Sapierzyński
authors: J
authors: J
authors: Micuń
authors: A
authors: A
authors: Majewska
authors: R
authors: R
authors: Lechowski
authors: T
authors: T
authors: Motyl
authors: M
authors: M
authors: Jank
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D008223:Lymphoma / Q000145:classification / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008297:Male; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods / Q000662:veterinary; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods / Q000662:veterinary; D059467:Transcriptome