title: Effective palladium-catalyzed hydroxycarbonylation of aryl halides with substoichiometric carbon monoxide.
abstract: A protocol for the Pd-catalyzed hydroxycarbonylation of aryl iodides, bromides, and chlorides has been developed using only 1-5 mol % of CO, corresponding to a p(CO) as low as 0.1 bar. Potassium formate is the only stoichiometric reagent, acting as a mildly basic nucleophile and a reservoir of CO. The substoichiometric CO could be delivered to the reaction from an acyl-Pd(II) precatalyst, which provides both the CO and an active catalyst, and thereby obviates the need for handling a toxic gas.
authors: The Center for Insoluble Protein Structures, Department of Chemistry and the Interdisciplinary Nanoscience Center, Aarhus University, Gustavs Wieds Vej 14, 8000 Aarhus, Denmark.
authors: Signe
authors: S
authors: Korsager
authors: Rolf H
authors: RH
authors: Taaning
authors: Troels
authors: T
authors: Skrydstrup
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010165:Palladium / Q000737:chemistry*
chemical_list: D006219:Halogens; D007659:Ketones; D010165:Palladium; D002248:Carbon Monoxide