title: The prevalence and risk factors of thrombocytopenia after living-related renal transplantation in Chinese adult recipients.
abstract: OBJECTIVE
  To evaluate the prevalence of and risk factors for thrombocytopenia during the first year after living-related renal transplantation of Chinese patients.
  
  
  METHODS
  This retrospective study was performed in 274 adult kidney transplant recipients between January 2009 and December 2010. We followed each for ≥ 1 year. Posttransplant thrombocytopenia (PTT) was defined as a platelet (PLT) count ≤ 100 × 10(9)/mL at any time after transplantation; a severe case was considered to be <50 × 10(9)/mL. Possible risk factors for PTT were analyzed using univariate methods with key factors determined by multivariate analysis.
  
  
  RESULTS
  The prevalence of PTT was high (33.9%) during the first year, but severe PTT occured only among 4.0% of patients. The lowest PLT often happened in the first 3 months after the operation. Key risk factors associated with PTT were induction therapy (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.3-4.1; P = .005) and infection (OR, 2.2; 95% CI, 1.3-3.8; P = .004) upon multivariate analysis. Severe PTT correlated with induction therapy (OR, 9.9; 95% CI, 1.7-56.2; P = .010) and acute rejection episodes (OR, 7.8; 95% CI, 1.4-42.4; P = .018).
  
  
  CONCLUSIONS
  PTT was quite prevalent in the first year after renal transplantation. Most recipients showed the lowest PLT count in the first 3 months. However, severe cases, which correlated with induction therapy and acute rejection episodes, were rare.
authors: Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors: L
authors: L
authors: Xie
authors: S
authors: S
authors: He
authors: L
authors: L
authors: Fu
authors: K
authors: K
authors: Ashok
authors: Z
authors: Z
authors: Huang
authors: L
authors: L
authors: Wang
authors: T
authors: T
authors: Lin
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011183:Postoperative Complications; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology