title: Contrasting effects on path integration after hippocampal damage in humans and rats.
abstract: The hippocampus and other medial temporal lobe structures have been linked to both memory and spatial cognition, but it has been unclear how these ideas are connected. We carried out parallel studies of path integration in patients with medial temporal lobe lesions and rats with hippocampal lesions. Subjects entered a circular arena without vision, searched for a target, and then attempted to return to the start location. Patients performed accurately, and as well as controls, so long as the outward path was relatively direct and the target was found within 20 s. In sharp contrast, rats with hippocampal lesions were impaired, even when the outward path was shorter than 1 m, involved no turns, and the target was found within 3 s. We suggest that patients succeeded because performance could be supported by working memory and that patients and rats differ after hippocampal lesions in their ability to construct a coherent working memory of spatial environments.
authors: Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.
authors: Soyun
authors: S
authors: Kim
authors: Maya
authors: M
authors: Sapiurka
authors: Robert E
authors: RE
authors: Clark
authors: Larry R
authors: LR
authors: Squire
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006624:Hippocampus / Q000293:injuries* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D051381:Rats; D020318:Rats, Long-Evans; D013702:Temporal Lobe / Q000293:injuries* / Q000503:physiopathology*
references: Neuron. 2003 Apr 10;38(1):127-33
references: 12691670
references: Learn Mem. 2011 Dec 16;19(1):15-25
references: 22180053
references: Front Neurosci. 2011 Mar 04;5:24
references: 21427795
references: Hippocampus. 2005;15(1):79-85
references: 15390163
references: Hippocampus. 1999;9(5):553-61
references: 10560926
references: Hippocampus. 2001;11(2):176-86
references: 11345124
references: Hum Brain Mapp. 2014 Jan;35(1):248-56
references: 22936605
references: Behav Neurosci. 1999 Feb;113(1):19-31
references: 10197903
references: Behav Neurosci. 2001 Dec;115(6):1212-23
references: 11770053
references: Annu Rev Neurosci. 2004;27:279-306
references: 15217334
references: PLoS Biol. 2005 Dec;3(12):e402
references: 16279838
references: Nat Rev Neurosci. 2006 Aug;7(8):663-78
references: 16858394
references: Cereb Cortex. 1996 Mar-Apr;6(2):311-8
references: 8670659
references: Science. 1970 Jun 26;168(3939):1604-5
references: 5420547
references: Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12034-8
references: 18687893
references: Behav Neurosci. 2003 Oct;117(5):1044-53
references: 14570553
references: Anim Behav. 1997 Aug;54(2):321-7
references: 9268463
references: Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12237-41
references: 22778411
references: Hippocampus. 1999;9(2):118-36
references: 10226773
references: Annu Rev Neurosci. 2011;34:259-88
references: 21456960
references: Brain Cogn. 2002 Mar-Apr;48(2-3):432-6
references: 12030483
references: Arch Neurol. 1966 Jul;15(1):52-61
references: 5937496
references: Nature. 2005 Jul 28;436(7050):550-3
references: 16049487
references: Front Integr Neurosci. 2010 Mar 10;4:2
references: 20431726
references: Hippocampus. 2004;14(2):180-92
references: 15098724
references: Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14755-62
references: 18812502
references: J Comp Physiol Psychol. 1974 Oct;87(4):772-80
references: 4426996
references: Behav Brain Res. 2001 Dec 14;127(1-2):49-69
references: 11718884
references: Psychol Rev. 1992 Apr;99(2):195-231
references: 1594723
references: J Neurosci. 2008 Apr 30;28(18):4818-22
references: 18448658
references: Neuropsychologia. 2010 Mar;48(4):1089-95
references: 20006631
references: Clin Neurosurg. 1972;19:421-46
references: 4637561
references: Behav Brain Res. 2006 Dec 15;175(2):329-36
references: 17045348
references: Neuron. 2005 Apr 7;46(1):141-51
references: 15820700
references: J Neurosci. 1996 Aug 15;16(16):5233-55
references: 8756452
references: J Neurosci. 2000 Dec 1;20(23):8853-60
references: 11102494
references: Neuroscience. 2009 Dec 1;164(2):444-56
references: 19665526
references: Exp Brain Res. 2004 Dec;159(3):349-59
references: 15526193