title: Open clinical trial for evaluation of efficacy and safety of a portable "dry-type" iontophoretic device in treatment of palmar hyperhidrosis.
abstract: BACKGROUND
  Palmar hyperhidrosis is characterized by excessive sweating on the palm. Although botulinum toxin is effective and safe treatment for palmar hyperhidrosis, some patients require inexpensive, easy-to-use therapeutic modalities.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of a portable "dry-type" iontophoretic device for treatment of palmar hyperhidrosis.
  
  
  METHODS
  Twenty-three volunteers with idiopathic palmar hyperhidrosis were enrolled; 20 completed the study.
  
  
  METHODS
  Participants were instructed to grasp the device with the left palm for 20 minutes once a day for 4 weeks. Follow-up evaluation was conducted during 4 weeks after termination of the treatment session. Sweat intensity, Investigator Global Assessment (IGA), patient satisfaction assessment (PSA), and hydration capacitance were measured for evaluation of efficacy. Adverse effects were investigated for evaluation of safety.
  
  
  RESULTS
  Statistically significantly greater improvement in IGA and hydration capacitance was achieved in the treated palm than in the untreated palm. Improvement in sweat intensity and PSA was not statistically significantly different in the treated and untreated palms. Two cases of mild local adverse effects were noted.
  
  
  CONCLUSIONS
  The device is an effective therapeutic modality for palmar hyperhidrosis in addition to local injection of botulinum toxin, endoscopic sympathectomy, and conventional iontophoretic treatments.
authors: Department of Dermatology, School of Medicine, Kyungpook National University, Daegu, Korea.
authors: Yoon Hyuk
authors: YH
authors: Choi
authors: Seok-Jong
authors: SJ
authors: Lee
authors: Do Won
authors: DW
authors: Kim
authors: Weon Ju
authors: WJ
authors: Lee
authors: Gun Yoen
authors: GY
authors: Na
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000503:physiopathology / Q000628:therapy*; D007478:Iontophoresis / Q000009:adverse effects / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D055815:Young Adult