title: Association of acute cerebellar ataxia and human papilloma virus vaccination: a case report.
abstract: BACKGROUND
  We report the case of a patient who developed symptoms of acute cerebellar ataxia (ACA) after administration of the human papilloma virus (HPV)-16/18 vaccine.
  
  
  METHODS
  This patient developed symptoms of ACA, including nausea, vertigo, severe limb and truncal ataxia, and bilateral spontaneous continuous horizontal nystagmus with irregular rhythm, 12 days after administration of the HPV-16/18 AS04-adjuvanted cervical cancer vaccine. After this, the patient received methylprednisolone pulse and intravenous immunoglobulin (IVIG) therapies as well as immunoadsorption plasmapheresis.
  
  
  RESULTS
  Severe ACA symptoms did not improve after methylprednisolone pulse and IVIG therapies, but the patient recovered completely after immunoadsorption plasmapheresis.
  
  
  CONCLUSIONS
  This temporal association strongly suggests that ACA was induced by the vaccination.
authors: Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, Japan.
authors: Chihiro
authors: C
authors: Yonee
authors: Mitsuo
authors: M
authors: Toyoshima
authors: Yoshihiro
authors: Y
authors: Maegaki
authors: Yuichi
authors: Y
authors: Kodama
authors: Hiroshi
authors: H
authors: Hayami
authors: Yukitoshi
authors: Y
authors: Takahashi
authors: Susumu
authors: S
authors: Kusunoki
authors: Ayumi
authors: A
authors: Uchibori
authors: Atsuro
authors: A
authors: Chiba
authors: Yoshifumi
authors: Y
authors: Kawano
mesh_terms: D000208:Acute Disease; D002524:Cerebellar Ataxia / Q000139:chemically induced* / Q000628:therapy; D002648:Child; D005260:Female; D052162:Human papillomavirus 16 / Q000276:immunology; D006801:Humans; D053918:Papillomavirus Vaccines / Q000009:adverse effects*; D010956:Plasmapheresis; D016896:Treatment Outcome; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D053918:Papillomavirus Vaccines