title: Transcriptional regulation of cell adhesion at the blood-testis barrier and spermatogenesis in the testis.
abstract: Spermatogenesis involves precise co-ordination of multiple cellular events that take place in the seminiferous epithelium composed of Sertoli cells and developing germ cells during the seminiferous epithelial cycle. Given the cyclic and co-ordinated nature of spermatogenesis, temporal and spatial expression of certain genes pertinent to a specific cellular event are essential. As such, transcriptional regulation is one of the major regulatory machineries in controlling the cell type- and stage-specific gene expression, some of which are under the influence of gonadotropins (e.g., FSH and LH) and sex steroids (e.g., testosterone and estradiol-17beta). Recent findings regarding transcriptional control of spermatogenesis, most notably target genes at the Sertoli-Sertoli and Sertoli-spermatid interface at the site of the blood-testis barrier (BTB) and apical ectoplasmic specialization (apical ES), respectively, involving in cell adhesion are reviewed and discussed herein. This is a much neglected area of research and a concerted effort by investigators is needed to understand transcriptional regulation of cell adhesion function in the testis particularly at the BTB during spermatogenesis.
authors: School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China. wylui@hku.hk
authors: Wing-Yee
authors: WY
authors: Lui
authors: C Yan
authors: CY
authors: Cheng
mesh_terms: D000818:Animals; D001814:Blood-Testis Barrier / Q000166:cytology / Q000378:metabolism*; D002448:Cell Adhesion; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007365:Intercellular Junctions / Q000235:genetics / Q000378:metabolism; D008297:Male; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism; D012670:Seminiferous Epithelium / Q000166:cytology / Q000378:metabolism; D012708:Sertoli Cells / Q000166:cytology / Q000378:metabolism; D013091:Spermatogenesis; D055153:Stem Cell Niche; D013737:Testis / Q000166:cytology / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D018398:Homeodomain Proteins; D011944:Receptors, Androgen; C498048:Rhox5 protein, mouse; D014157:Transcription Factors
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