title: A simple screening test for the detection of erythropoietin antibodies.
abstract: Antibody-mediated pure red cell aplasia (PRCA) is a rare complication of erythropoietin (EPO) therapy. Identification and demonstration of functional activity of EPO antibodies required to diagnose this condition is difficult and only performed in selected laboratories worldwide. In this article we report a recent cluster of three cases of antibody-mediated PRCA over a 16-month period in a single center associated with EPREX use. We also describe the use of a simple low-cost inhibitor assay that can be used to screen for PRCA in local laboratories.
authors: Soma
authors: S
authors: Meran
authors: Alexa
authors: A
authors: Wonnacott
authors: Mat
authors: M
authors: Davies
authors: Richard
authors: R
authors: Ellis
authors: Aled
authors: A
authors: Phillips
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D057134:Antibodies, Neutralizing / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002138:Calibration; D000068817:Epoetin Alfa; D004921:Erythropoietin / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011994:Recombinant Proteins / Q000009:adverse effects / Q000276:immunology; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis* / Q000276:immunology; D012015:Reference Standards; D012698:Serologic Tests / Q000592:standards
chemical_list: D057134:Antibodies, Neutralizing; D015415:Biomarkers; D011994:Recombinant Proteins; D004921:Erythropoietin; D000068817:Epoetin Alfa