title: Radiographically determined noninvasive adenocarcinoma of the lung: survival outcomes of Japan Clinical Oncology Group 0201.
abstract: OBJECTIVE
  The study objective was to evaluate the long-term survival of patients with radiographically determined noninvasive lung adenocarcinomas.
  
  
  METHODS
  A prospective, multi-institutional study on image diagnosis to define early (noninvasive) adenocarcinomas of the lung (Japan Clinical Oncology Group 0201) has shown that a consolidation/tumor ratio on thin-section computed tomography 0.25 or less in cT1a (≤2.0 cm) could be used as a better radiologic criterion for a noninvasive pathology than a consolidation/tumor ratio 0.50 or less in cT1a-b (≤3.0 cm). From the prognostic viewpoints, these criteria were evaluated for 545 patients with adenocarcinoma who underwent lobectomy and lymph node dissection.
  
  
  RESULTS
  The subjects consisted of 233 men and 312 women with a median age of 62 years. The median follow-up period among overall patients was 7.1 years (range, 0-8.5 years). The overall and relapse-free 5-year survivals of the overall patients were 90.6% and 84.7%, respectively. When a consolidation/tumor ratio 0.5 or less in cT1a-b was used as a cutoff, the 5-year overall survivals of radiologic noninvasive (121 patients, 22.2%) and invasive (424 patients, 77.8%) adenocarcinomas were 96.7% and 88.9%, respectively, and the difference was statistically significant (P < .001, log-rank test). With the use of a consolidation/tumor ratio 0.25 or less in cT1a, the 5-year overall survivals of radiologic noninvasive (35 patients, 12.1%) and invasive (254 patients, 87.9%) adenocarcinomas were 97.1% and 92.4%, respectively, and the difference was not statistically significant (P = .259).
  
  
  CONCLUSIONS
  The radiologic criteria of a consolidation/tumor ratio 0.25 or less in cT1a (≤2.0 cm) and 0.50 in cT1a-b (≤3.0 cm) were both able to define a homogeneous group of patients with an excellent prognosis before surgery.
authors: National Cancer Center Hospital, Tokyo, Japan. hasamura@ncc.go.jp
authors: Hisao
authors: H
authors: Asamura
authors: Tomoyuki
authors: T
authors: Hishida
authors: Kenji
authors: K
authors: Suzuki
authors: Teruaki
authors: T
authors: Koike
authors: Kenichi
authors: K
authors: Nakamura
authors: Masahiko
authors: M
authors: Kusumoto
authors: Kanji
authors: K
authors: Nagai
authors: Hirohito
authors: H
authors: Tada
authors: Tetsuya
authors: T
authors: Mitsudomi
authors: Masahiro
authors: M
authors: Tsuboi
authors: Taro
authors: T
authors: Shibata
authors: Haruhiko
authors: H
authors: Fukuda
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D011859:Radiography; D015996:Survival Rate