title: Paravalvular leak after transcatheter aortic valve replacement: the new Achilles' heel? A comprehensive review of the literature.
abstract: Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) and is seen at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be correlated with increased late mortality have raised concerns. However, the heterogeneity of methods for assessing and quantifying PVL, and lack of consistency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity, and effect. This literature review is an effort to consolidate current knowledge in this area to better understand the prevalence, progression, and impact of post-TAVR PVL and to help direct future efforts regarding the assessment, prevention, and treatment of this troublesome complication.
authors: Columbia University Medical Center/New York Presbyterian Hospital, New York, NY, USA.
authors: Philippe
authors: P
authors: Généreux
authors: Stuart J
authors: SJ
authors: Head
authors: Rebecca
authors: R
authors: Hahn
authors: Benoit
authors: B
authors: Daneault
authors: Susheel
authors: S
authors: Kodali
authors: Mathew R
authors: MR
authors: Williams
authors: Nicolas M
authors: NM
authors: van Mieghem
authors: Maria C
authors: MC
authors: Alu
authors: Patrick W
authors: PW
authors: Serruys
authors: A Pieter
authors: AP
authors: Kappetein
authors: Martin B
authors: MB
authors: Leon
mesh_terms: D001021:Aortic Valve / Q000601:surgery*; D006328:Cardiac Catheterization; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy; D011474:Prosthesis Design