title: Gallic acid modulates cerebral oxidative stress conditions and activities of enzyme-dependent signaling systems in streptozotocin-treated rats.
abstract: Redox imbalances and altered signaling processes in the brain are characteristic features of diabetic complications. Hence, the present study therefore sought to evaluate the effect of gallic acid (GA) on disturbed redox systems and activity of neurotransmission signaling dependent enzymes such as sodium pump, purinergic enzymes and acetylcholinesterase in diabetic animal models. We observed that GA markedly improves the antioxidant status of diabetic animals. Furthermore, the diminution of the activity of Na(+)/K(+)-ATPase and increased activities of acetylcholinesterase and the purinergic enzymes associated with diabetes progression were reversed to normalcy with the administration of GA in diabetic animals. Hence, we conclude that GA is a potential candidate in the management of neuronal dysfunction that often accompanied complications associated with diabetic hyperglycemia.
authors: Department of Biochemistry, Federal University of Technology, Akure, Ondo State, Nigeria. ijkade@yahoo.com
authors: I J
authors: IJ
authors: Kade
authors: J B T
authors: JB
authors: Rocha
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005707:Gallic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D006943:Hyperglycemia; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D013311:Streptozocin; D005707:Gallic Acid; D000110:Acetylcholinesterase; D000254:Sodium-Potassium-Exchanging ATPase
references: Toxicol Lett. 2001 Dec 15;125(1-3):143-50
references: 11701233
references: Toxicol Appl Pharmacol. 1998 Apr;149(2):243-53
references: 9571994
references: Arch Biochem Biophys. 1959 May;82(1):70-7
references: 13650640
references: Diabetes. 1991 Apr;40(4):405-12
references: 2010041
references: Biofactors. 2007;31(2):77-98
references: 18806312
references: Cell Biol Toxicol. 2009 Aug;25(4):415-24
references: 18668330
references: J Biochem Mol Toxicol. 2011 Mar-Apr;25(2):68-76
references: 21472896
references: Arch Neurol. 2004 May;61(5):661-6
references: 15148141
references: J Biochem Mol Toxicol. 2011 Mar-Apr;25(2):101-7
references: 20957663
references: J Biol Chem. 1951 Nov;193(1):265-75
references: 14907713
references: Diabetes Metab. 2002 Nov;28(5):377-84
references: 12461474
references: Cell Biol Int. 2010 Dec;34(12):1147-53
references: 20662768
references: Food Chem Toxicol. 2004 Sep;42(9):1401-8
references: 15234070
references: Brain Res. 2009 Aug 11;1284:202-11
references: 19362073
references: Enzyme. 1982;28(2-3):133-45
references: 7140716
references: Braz J Med Biol Res. 2002 Jun;35(6):623-31
references: 12045826
references: Diabetes. 2011 Jun;60(6):1789-96
references: 21562076
references: Neurochem Res. 2005 Feb;30(2):225-35
references: 15895826
references: Diabetes. 1987 Sep;36(9):1014-8
references: 3301471
references: Neurochem Int. 2008 Mar-Apr;52(4-5):634-48
references: 18029057
references: Eur J Pain. 2008 Jul;12(5):624-32
references: 18055235
references: Eur J Pharmacol. 2007 Dec 8;576(1-3):34-42
references: 17822693
references: Cancer Lett. 1997 Mar 19;114(1-2):7-9
references: 9103244
references: Neurochem Res. 2006 Apr;31(4):455-62
references: 16758353
references: Neurochem Res. 2008 Jan;33(1):167-78
references: 17710541
references: Physiol Res. 2001;50(6):537-46
references: 11829314
references: Pharmacol Toxicol. 1998 Sep;83(3):95-103
references: 9783327
references: Neurochem Res. 1991 Dec;16(12):1303-10
references: 1838406
references: Diabetes Metab Res Rev. 2010 Oct;26(7):507-19
references: 20799243
references: Anal Biochem. 1979 Jun;95(2):351-8
references: 36810
references: IUBMB Life. 2000 Apr;49(4):283-7
references: 10995030
references: Trends Neurosci. 1992 Dec;15(12):485-90
references: 1282748
references: Diabetes Care. 2007 Apr;30(4):1027-32
references: 17392563
references: N Engl J Med. 1987 Mar 5;316(10):599-606
references: 3027558
references: Diabetologia. 2006 Jun;49(6):1447-8
references: 16598451
references: J Toxicol Environ Health A. 1998 Oct 9;55(3):225-40
references: 9772105
references: Exp Toxicol Pathol. 2011 Mar;63(3):249-55
references: 20122821
references: Biochem Pharmacol. 1961 Jul;7:88-95
references: 13726518
references: J Neurochem. 1984 Oct;43(4):971-8
references: 6088700
references: Eur J Pharmacol. 2011 Jan 10;650(1):465-71
references: 20863784
references: Eur J Pharmacol. 2004 Apr 19;490(1-3):187-97
references: 15094085
references: J Agric Food Chem. 2000 Aug;48(8):3396-402
references: 10956123
references: Pharmacol Toxicol. 2001 Mar;88(3):119-25
references: 11245406
references: Lancet Neurol. 2008 Feb;7(2):184-90
references: 18207116
references: Rev Cardiovasc Med. 2011;12(1):21-9
references: 21546885
references: Physiol Rev. 2008 Apr;88(2):333-49
references: 18391166
references: Biochim Biophys Acta. 1995 Jul 26;1237(2):143-50
references: 7632707
references: Toxicol Lett. 2000 Sep 30;117(1-2):45-52
references: 11033232
references: Toxicology. 1995 Jun 26;100(1-3):27-37
references: 7624881
references: J Bioenerg Biomembr. 1995 Apr;27(2):169-79
references: 7592564
references: Curr Top Pathol. 1987;77:19-45
references: 2448087
references: J Biol Chem. 1974 Nov 25;249(22):7130-9
references: 4436300
references: Chem Biol Interact. 2006 Nov 7;163(3):230-8
references: 16965767
references: Toxicology. 1995 Nov 30;103(2):85-103
references: 8545848
references: Neuroscience. 2002;110(4):627-39
references: 11934471
references: Diabetes. 1987 Mar;36(3):396-406
references: 3026877
references: Crit Rev Biochem Mol Biol. 1995;30(6):445-600
references: 8770536
references: Methods Enzymol. 1984;105:121-6
references: 6727660
references: Diabetes Res Clin Pract. 2004 Jul;65(1):1-6
references: 15163471
references: Neurochem Res. 2006 Aug;31(8):1027-34
references: 16871442
references: J Enzyme Inhib Med Chem. 2007 Apr;22(2):213-7
references: 17518348
references: Chem Biol Interact. 2011 Jan 15;189(1-2):112-8
references: 21078310