title: Dexamethasone-eluting vascular stents.
abstract: Percutaneous transluminal angioplasty (PTA) with stenting is widely used in the treatment of vascular disorders, but restenosis remains a significant problem. Drug-eluting stents (DES) have been developed as an attempt to reduce the intimal response leading to restenosis. Drugs used in DES include mainly immunosuppressive and anti-proliferative compounds. Glucocorticoids are also an interesting possibility for those purposes because they have anti-proliferative effects in vascular smooth muscle cells and down-regulate the production of cytokines and growth factors driving inflammation and fibrosis. In this MiniReview, feasibility and safety of drug-eluting metal and biodegradable vascular stents are discussed with special emphasis on dexamethasone-eluting stents.
authors: The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland.
authors: Mari
authors: M
authors: Hämäläinen
authors: Riina
authors: R
authors: Nieminen
authors: Ilkka
authors: I
authors: Uurto
authors: Juha-Pekka
authors: JP
authors: Salenius
authors: Minna
authors: M
authors: Kellomäki
authors: Joonas
authors: J
authors: Mikkonen
authors: Andres
authors: A
authors: Kotsar
authors: Taina
authors: T
authors: Isotalo
authors: L J
authors: LJ
authors: Teuvo Tammela
authors: Martti
authors: M
authors: Talja
authors: Eeva
authors: E
authors: Moilanen
mesh_terms: D020341:Absorbable Implants; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods; D002986:Clinical Trials as Topic; D023903:Coronary Restenosis / Q000209:etiology / Q000517:prevention & control*; D003331:Coronary Vessels / Q000187:drug effects; D003907:Dexamethasone / Q000008:administration & dosage*; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005240:Feasibility Studies; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control
chemical_list: D003907:Dexamethasone