title: Diversity of killer cell immunoglobulin like receptor genes in the Mongolian population.
abstract: Killer cell immunoglobulin like receptor (KIR) is highly polymorphic in genotype, haplotype and allele levels. This study was done to investigate KIR genes frequencies, genotypes and inheritance in Mongolian. Gene-specific PCR amplification was used to identify the presence or absence of 16 KIR loci.KIR genotypes were obtained by a KIR genotypes website. The KIR genes frequencies of Mongolian were compared to 24 different populations around the world. The distribution of haplotype B in Mongolian was higher than that in Mongoloid and less than that in Caucasian. Thirty discovered genotypes and five novel genotypes were identified from 1 to 34 individuals. 37.8% of Mongolian carried KIR haplotype AA.Mongolian was exhibited between North Mongoloid and Caucasus by principal component and genetic tree analysis.
authors: Department of Medical Oncology, The Fourth Affiliated Hospital of Soochow University, Wuxi, China.
authors: Bo
authors: B
authors: Jiang
authors: Aili
authors: A
authors: Wang
authors: Zhong
authors: Z
authors: Ju
authors: Yonghong
authors: Y
authors: Zhang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D016000:Cluster Analysis; D005787:Gene Frequency; D056426:Genetic Loci; D005838:Genotype; D006801:Humans; D010802:Phylogeny; D011110:Polymorphism, Genetic; D025341:Principal Component Analysis; D054340:Receptors, KIR / Q000235:genetics*
chemical_list: D054340:Receptors, KIR