title: Relationship between mean platelet volume and low-grade systemic coagulation with vitamin D deficiency in primary ovarian insufficiency.
abstract: OBJECTIVE
  Premature menopause in young women is associated with an increased incidence of cardiovascular disease. The present study was designed to determine vitamin D (vit D) and the coagulation parameters such as activated partial thromboplastin time (APTT), PT, D-dimer, white blood cell (WBC), and mean platelet volume (MPV) levels, in primary ovarian insufficiency (POI) patients and control women with a normal menstrual cycle.
  
  
  METHODS
  A total of 43 patients with non-diabetic POI were studied in order to evaluate and compare with the control group comprising 33 women with a normal menstrual cycle.
  
  
  RESULTS
  There was no significant difference between the groups for age and body mass index (BMI). D-dimer, WBC, MPV, PT, total cholesterol, and LDL cholesterol were higher in women with POI. APTT levels were also increased but missed the significance in POI group. Women with POI had significantly lower serum vit D levels compared with healthy control group. FSH level was positively correlated with D-dimer, WBC, MPV, and negatively correlated to vit D and serum D vit level was inversely correlated with MPV, APTT, D-dimer, FSH levels in individual women.
  
  
  CONCLUSIONS
  The obtained results seem to indicate that POI patients had low-grade systemic coagulation and fibrinolytic activation as evidenced by elevated D-dimer, WBC, MPV, PT values potentially be used as indicators of risk factor for thrombosis and atherosclerosis in POI women. All of our patients with POI were deficient in vit D. These results also suggest that vit D deficiency plays important roles of POI women and associated with coagulation, independently from age and BMI.
authors: Clinic of Obstetrics and Gynecology, Beyhekim State Hospital, Konya, Turkey.
authors: Ayse Gul
authors: AG
authors: Kebapcilar
authors: Mustafa
authors: M
authors: Kulaksizoglu
authors: Suleyman Hilmi
authors: SH
authors: Ipekci
authors: Huseyin
authors: H
authors: Korkmaz
authors: Levent
authors: L
authors: Kebapcilar
authors: Fikret
authors: F
authors: Akyurek
authors: Cüneyt Eftal
authors: CE
authors: Taner
authors: Mustafa Sait
authors: MS
authors: Gonen
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D001792:Blood Platelets / Q000473:pathology*; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007958:Leukocyte Count; D008594:Menopause, Premature / Q000097:blood*; D010314:Partial Thromboplastin Time; D016649:Primary Ovarian Insufficiency / Q000097:blood* / Q000150:complications; D011517:Prothrombin Time; D018709:Statistics, Nonparametric; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications
chemical_list: D008078:Cholesterol, LDL; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D014807:Vitamin D; D005640:Follicle Stimulating Hormone