title: Color-matched and fluorescence-labeled esophagus phantom and its applications.
abstract: We developed a stable, reproducible three-dimensional optical phantom for the evaluation of a wide-field endoscopic molecular imaging system. This phantom mimicked a human esophagus structure with flexibility to demonstrate body movements. At the same time, realistic visual appearance and diffuse spectral reflectance properties of the tissue were simulated by a color matching methodology. A photostable dye-in-polymer technology was applied to represent biomarker probed "hot-spot" locations. Furthermore, fluorescent target quantification of the phantom was demonstrated using a 1.2 mm ultrathin scanning fiber endoscope with concurrent fluorescence-reflectance imaging.
authors: University of Washington, Department of Bioengineering, 204 Fluke Hall, 4000 Mason Road, Seattle, WA 98195, USA. yangcy@uw.edu
authors: Chenying
authors: C
authors: Yang
authors: Vivian
authors: V
authors: Hou
authors: Leonard Y
authors: LY
authors: Nelson
authors: Eric J
authors: EJ
authors: Seibel
mesh_terms: D000465:Algorithms; D003116:Color; D004945:Esophagoscopy / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D004947:Esophagus; D005456:Fluorescent Dyes; D006801:Humans; D007840:Latex; D057054:Molecular Imaging / Q000295:instrumentation* / Q000379:methods / Q000706:statistics & numerical data; D055100:Optical Fibers; D055620:Optical Phenomena; D019047:Phantoms, Imaging
chemical_list: D005456:Fluorescent Dyes; D007840:Latex
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