title: Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium.
abstract: Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes have not been well defined. As the prevalence of obesity has increased dramatically, and classification of ovarian histology has improved in the last decade, we sought to examine the association in a pooled analysis of recent studies participating in the Ovarian Cancer Association Consortium. We evaluated the association between BMI (recent, maximum and in young adulthood) and ovarian cancer risk using original data from 15 case-control studies (13 548 cases and 17 913 controls). We combined study-specific adjusted odds ratios (ORs) using a random-effects model. We further examined the associations by histological subtype, menopausal status and post-menopausal hormone use. High BMI (all time-points) was associated with increased risk. This was most pronounced for borderline serous (recent BMI: pooled OR=1.24 per 5 kg/m(2); 95% CI 1.18-1.30), invasive endometrioid (1.17; 1.11-1.23) and invasive mucinous (1.19; 1.06-1.32) tumours. There was no association with serous invasive cancer overall (0.98; 0.94-1.02), but increased risks for low-grade serous invasive tumours (1.13, 1.03-1.25) and in pre-menopausal women (1.11; 1.04-1.18). Among post-menopausal women, the associations did not differ between hormone replacement therapy users and non-users. Whilst obesity appears to increase risk of the less common histological subtypes of ovarian cancer, it does not increase risk of high-grade invasive serous cancers, and reducing BMI is therefore unlikely to prevent the majority of ovarian cancer deaths. Other modifiable factors must be identified to control this disease.
authors: Queensland Institute of Medical Research, Royal Brisbane Hospital, Locked Bag 2000, Brisbane, Queensland 4029, Australia. catherine.olsen@qimr.edu.au
authors: Catherine M
authors: CM
authors: Olsen
authors: Christina M
authors: CM
authors: Nagle
authors: David C
authors: DC
authors: Whiteman
authors: Roberta
authors: R
authors: Ness
authors: Celeste Leigh
authors: CL
authors: Pearce
authors: Malcolm C
authors: MC
authors: Pike
authors: Mary Anne
authors: MA
authors: Rossing
authors: Kathryn L
authors: KL
authors: Terry
authors: Anna H
authors: AH
authors: Wu
authors: Harvey A
authors: HA
authors: Risch
authors: Herbert
authors: H
authors: Yu
authors: Jennifer A
authors: JA
authors: Doherty
authors: Jenny
authors: J
authors: Chang-Claude
authors: Rebecca
authors: R
authors: Hein
authors: Stefan
authors: S
authors: Nickels
authors: Shan
authors: S
authors: Wang-Gohrke
authors: Marc T
authors: MT
authors: Goodman
authors: Michael E
authors: ME
authors: Carney
authors: Rayna K
authors: RK
authors: Matsuno
authors: Galina
authors: G
authors: Lurie
authors: Kirsten
authors: K
authors: Moysich
authors: Susanne K
authors: SK
authors: Kjaer
authors: Allan
authors: A
authors: Jensen
authors: Estrid
authors: E
authors: Hogdall
authors: Ellen L
authors: EL
authors: Goode
authors: Brooke L
authors: BL
authors: Fridley
authors: Robert A
authors: RA
authors: Vierkant
authors: Melissa C
authors: MC
authors: Larson
authors: Joellen
authors: J
authors: Schildkraut
authors: Cathrine
authors: C
authors: Hoyo
authors: Patricia
authors: P
authors: Moorman
authors: Rachel P
authors: RP
authors: Weber
authors: Daniel W
authors: DW
authors: Cramer
authors: Allison F
authors: AF
authors: Vitonis
authors: Elisa V
authors: EV
authors: Bandera
authors: Sara H
authors: SH
authors: Olson
authors: Lorna
authors: L
authors: Rodriguez-Rodriguez
authors: Melony
authors: M
authors: King
authors: Louise A
authors: LA
authors: Brinton
authors: Hannah
authors: H
authors: Yang
authors: Montserrat
authors: M
authors: Garcia-Closas
authors: Jolanta
authors: J
authors: Lissowska
authors: Hoda
authors: H
authors: Anton-Culver
authors: Argyrios
authors: A
authors: Ziogas
authors: Simon A
authors: SA
authors: Gayther
authors: Susan J
authors: SJ
authors: Ramus
authors: Usha
authors: U
authors: Menon
authors: Aleksandra
authors: A
authors: Gentry-Maharaj
authors: Penelope M
authors: PM
authors: Webb
mesh_terms: D015992:Body Mass Index; D005260:Female; D006801:Humans; D060787:Neoplasm Grading; D009765:Obesity / Q000453:epidemiology* / Q000473:pathology; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000453:epidemiology*; D012306:Risk; D012955:Societies, Medical
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