title: Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.
abstract: The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.
authors: Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
authors: Soek Sin
authors: SS
authors: Teh
authors: Gwendoline Cheng Lian
authors: GC
authors: Ee
authors: Siau Hui
authors: SH
authors: Mah
authors: Yang Mooi
authors: YM
authors: Lim
authors: Zuraini
authors: Z
authors: Ahmad
mesh_terms: D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D028084:Clusiaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D011794:Quercetin / Q000494:pharmacology; D013329:Structure-Activity Relationship; D044004:Xanthones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D044004:Xanthones; C009689:xanthone; D011794:Quercetin
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