title: Proteomic identification of biomarkers of skeletal muscle disorders.
abstract: Disease-specific biomarkers play a central diagnostic and therapeutic role in muscle pathology. Serum levels of a variety of muscle-derived enzymes are routinely used for the detection of muscle damage in diagnostic procedures, as well as for the monitoring of physical training status in sports medicine. Over the last few years, the systematic application of mass spectrometry-based proteomics for studying skeletal muscle degeneration has greatly expanded the range of muscle biomarkers, including new fiber-associated proteins involved in muscle transformation, muscular atrophy, muscular dystrophy, motor neuron disease, inclusion body myositis, myotonia, hypoxia, diabetes, obesity and sarcopenia of old age. These mass spectrometric studies have clearly established skeletal muscle proteomics as a reliable method for the identification of novel indicators of neuromuscular diseases.
authors: Muscle Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland. kay.ohlendieck@nuim.ie
authors: Kay
authors: K
authors: Ohlendieck
mesh_terms: D015415:Biomarkers / Q000097:blood*; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D016472:Motor Neuron Disease / Q000378:metabolism / Q000473:pathology; D018482:Muscle, Skeletal / Q000378:metabolism*; D009133:Muscular Atrophy / Q000378:metabolism / Q000473:pathology; D009136:Muscular Dystrophies / Q000378:metabolism / Q000473:pathology; D018979:Myositis, Inclusion Body / Q000378:metabolism / Q000473:pathology; D009222:Myotonia / Q000378:metabolism / Q000473:pathology; D009765:Obesity / Q000378:metabolism / Q000473:pathology; D020543:Proteome / Q000378:metabolism; D040901:Proteomics
chemical_list: D015415:Biomarkers; D020543:Proteome