title: Identifying a predictive model for response to atypical antipsychotic monotherapy treatment in south Indian schizophrenia patients.
abstract: Atypical antipsychotic (AAP) drugs are the preferred choice of treatment for schizophrenia patients. Patients who do not show favorable response to AAP monotherapy are subjected to random prolonged therapeutic treatment with AAP multitherapy, typical antipsychotics or a combination of both. Therefore, prior identification of patients' response to drugs can be an important step in providing efficacious and safe therapeutic treatment. We thus attempted to elucidate a genetic signature which could predict patients' response to AAP monotherapy. Our logistic regression analyses indicated the probability that 76% patients carrying combination of four SNPs will not show favorable response to AAP therapy. The robustness of this prediction model was assessed using repeated 10-fold cross validation method, and the results across n-fold cross-validations (mean accuracy=71.91%; 95%CI=71.47-72.35) suggest high accuracy and reliability of the prediction model. Further validations of these results in large sample sets are likely to establish their clinical applicability.
authors: Genomics and Molecular Medicine, Institute of Genomics and Integrative Biology Council of Scientific and Industrial Research, Mall Road, Delhi 110 007, India.
authors: Meenal
authors: M
authors: Gupta
authors: Nagaraj S
authors: NS
authors: Moily
authors: Harpreet
authors: H
authors: Kaur
authors: Ajay
authors: A
authors: Jajodia
authors: Sanjeev
authors: S
authors: Jain
authors: Ritushree
authors: R
authors: Kukreti
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents
keywords: AAP; AUC; Antipsychotic drugs; Area Under the Curve; Atypical Antipsychotic; CGI; Clinical Global Impressions; DSM IV; Diagnostic and Statistical Manual of Mental Disorders Fourth Revision; Gene–gene interaction; Logistic regression; NIMHANS; NPV; National Institute of Mental Health and Neurosciences; Negative Predictive Value; PPV; Pharmacogenetics; Positive Predictive Value; QC; Quality Control; ROC; Receiver Operating Characteristic; SCAN; SNP; SPSS; SZ; Schedules for Clinical Assessment in Neuropsychiatry; Single Nucleotide Polymorphisms; Single nucleotide polymorphisms; Statistical Package for Social Sciences; TAP; Typical Antipsychotics; schizophrenia