title: Nutrient sensing, metabolism, and cell growth control.
abstract: Cell growth is regulated by coordination of both extracellular nutrients and intracellular metabolite concentrations. AMP-activated kinase and mammalian target of rapamycin complex 1 serve as key molecules that sense cellular energy and nutrients levels, respectively. In addition, the members of the dioxygenase family, including prolylhydroxylase, lysine demethylase, and DNA demethylase, have emerged as possible sensors of intracellular metabolic status. The interplay among nutrients, metabolites, gene expression, and protein modification are involved in the coordination of cell growth with extracellular and intracellular conditions.
authors: Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors: Hai-Xin
authors: HX
authors: Yuan
authors: Yue
authors: Y
authors: Xiong
authors: Kun-Liang
authors: KL
authors: Guan
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000818:Animals; D049109:Cell Proliferation; D002477:Cells / Q000201:enzymology / Q000378:metabolism*; D044127:Epigenesis, Genetic; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
chemical_list: D055372:AMP-Activated Protein Kinases
references: Genes Dev. 2004 Dec 1;18(23):2893-904
references: 15545625
references: J Cell Biol. 2000 Sep 18;150(6):1507-13
references: 10995454
references: Am J Physiol. 1997 Dec;273(6):E1107-12
references: 9435525
references: Cell. 2003 Nov 26;115(5):577-90
references: 14651849
references: Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12017-22
references: 17609368
references: Nature. 2004 Sep 9;431(7005):200-5
references: 15306821
references: Trends Biochem Sci. 2004 Jan;29(1):18-24
references: 14729328
references: Diabetes. 2004 Nov;53(11):2748-56
references: 15504954
references: Annu Rev Genet. 2009;43:67-93
references: 19653858
references: Nature. 2012 May 02;485(7396):109-13
references: 22552098
references: Mol Cell. 2010 May 28;38(4):487-99
references: 20513425
references: Nature. 2006 Feb 16;439(7078):811-6
references: 16362057
references: Eur J Biochem. 1992 Feb 1;203(3):615-23
references: 1346520
references: Mol Cell. 2011 Oct 7;44(1):134-46
references: 21981924
references: Cancer Cell. 2005 Jan;7(1):77-85
references: 15652751
references: Genes Dev. 2001 Oct 15;15(20):2675-86
references: 11641274
references: Science. 2011 Jun 10;332(6035):1322-6
references: 21659605
references: Nat Cell Biol. 2008 Aug;10(8):935-45
references: 18604198
references: Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15201-6
references: 21876130
references: Curr Biol. 2002 Aug 20;12(16):1419-23
references: 12194824
references: Cell. 2012 Apr 13;149(2):410-24
references: 22424946
references: Genes Cancer. 2011 Jun;2(6):663-79
references: 21941621
references: Annu Rev Cell Dev Biol. 2011;27:107-32
references: 21801009
references: Semin Cell Dev Biol. 2012 Jun;23(4):370-80
references: 22306135
references: Mol Cell. 2008 Apr 25;30(2):214-26
references: 18439900
references: Nat Cell Biol. 2011 Feb;13(2):132-41
references: 21258367
references: J Biol Chem. 2007 Feb 16;282(7):4524-4532
references: 17182618
references: Mol Cell Biol. 2006 Sep;26(17):6425-34
references: 16914728
references: Mol Cell. 2008 May 23;30(4):393-402
references: 18498744
references: Nat Cell Biol. 2007 Feb;9(2):218-24
references: 17237771
references: Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15983-7
references: 12444247
references: J Biol Chem. 2006 Nov 17;281(46):34870-9
references: 16990266
references: Biochem Soc Trans. 2002 Apr;30(2):264-70
references: 12023862
references: Mol Cell. 2009 Sep 11;35(5):563-73
references: 19748353
references: J Appl Physiol (1985). 2000 Jun;88(6):2219-26
references: 10846039
references: Curr Opin Cell Biol. 2010 Apr;22(2):157-68
references: 20006481
references: PLoS One. 2009 Jul 10;4(7):e6189
references: 19593385
references: Nat Rev Cancer. 2008 Jan;8(1):51-6
references: 18046334
references: Biochem Soc Trans. 2006 Feb;34(Pt 1):7-11
references: 16246168
references: Science. 2011 Jun 17;332(6036):1433-5
references: 21680840
references: Annu Rev Microbiol. 2005;59:407-50
references: 16153175
references: J Biol Chem. 2004 Mar 26;279(13):12220-31
references: 14709557
references: Chem Soc Rev. 2011 Aug;40(8):4364-97
references: 21390379
references: FEBS Lett. 1988 Aug 1;235(1-2):144-8
references: 2900158
references: Science. 2011 Nov 4;334(6056):678-83
references: 22053050
references: Mol Cell. 2012 Jun 29;46(6):833-46
references: 22575674
references: Cell. 2011 Nov 11;147(4):728-41
references: 22078875
references: Cancer Cell. 2007 Aug;12(2):108-13
references: 17692803
references: Mol Cell. 2012 Apr 13;46(1):105-10
references: 22424774
references: Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14056-61
references: 17709744
references: Science. 2011 Jun 10;332(6035):1317-22
references: 21659604
references: Science. 2011 Jan 28;331(6016):456-61
references: 21205641
references: Diabetes. 2004 Dec;53(12):3074-81
references: 15561936
references: Cell. 2008 Aug 8;134(3):405-15
references: 18674809
references: Science. 2009 May 22;324(5930):1029-33
references: 19460998
references: Nature. 2009 Dec 10;462(7274):739-44
references: 19935646
references: J Cell Biol. 2004 Jul 19;166(2):213-23
references: 15249583
references: Science. 2008 Jun 13;320(5882):1496-501
references: 18497260
references: Nat Cell Biol. 2003 Jun;5(6):566-71
references: 12766776
references: Mol Cell. 2010 Jul 30;39(2):171-83
references: 20670887
references: Cancer Cell. 2010 Dec 14;18(6):553-67
references: 21130701
references: Genes Dev. 2002 Jun 15;16(12):1466-71
references: 12080085
references: Genes Dev. 2012 Jun 15;26(12):1326-38
references: 22677546
references: Biochim Biophys Acta. 1989 Jun 15;1012(1):81-6
references: 2567185
references: Genes Dev. 2011 Sep 15;25(18):1895-908
references: 21937710
references: Science. 2009 May 15;324(5929):930-5
references: 19372391
references: Int J Mol Med. 2007 Mar;19(3):475-83
references: 17273797
references: Mol Cell. 2010 Oct 22;40(2):294-309
references: 20965423
references: Nature. 2010 Jun 17;465(7300):942-6
references: 20526321
references: Curr Opin Genet Dev. 2008 Feb;18(1):54-61
references: 18387799
references: Cell. 2010 Apr 16;141(2):290-303
references: 20381137
references: EMBO Rep. 2007 Apr;8(4):360-5
references: 17347671
references: Mol Cell. 2013 Jan 10;49(1):172-85
references: 23142078
references: Cancer Cell. 2011 Jan 18;19(1):17-30
references: 21251613
references: Oncogene. 2010 May 20;29(20):2962-72
references: 20228846
references: Curr Biol. 2000 Oct 19;10(20):1247-55
references: 11069105
references: Mol Cell Biol. 2005 Jul;25(14):5834-45
references: 15988001
references: Cell. 2011 Aug 5;146(3):408-20
references: 21816276
references: Nature. 2007 Nov 29;450(7170):736-40
references: 18046414
references: Genes Dev. 2003 Aug 1;17(15):1829-34
references: 12869586
references: J Biol Chem. 2002 Jul 19;277(29):26351-5
references: 12042299
references: Cell. 2004 Jun 25;117(7):941-52
references: 15210114
references: J Clin Invest. 2007 Feb;117(2):387-96
references: 17273556
references: J Cell Biol. 2001 May 28;153(5):1011-22
references: 11381086
references: Science. 2009 Apr 10;324(5924):261-5
references: 19359588
references: Nat Rev Cancer. 2008 Nov;8(11):851-64
references: 18846101
references: J Biol Chem. 2005 Mar 18;280(11):9769-72
references: 15632201
references: Nat Rev Mol Cell Biol. 2007 Oct;8(10):774-85
references: 17712357
references: Nature. 2011 Apr 14;472(7342):230-3
references: 21399626
references: Science. 2002 Feb 1;295(5556):858-61
references: 11823643
references: Cell Metab. 2008 Sep;8(3):224-36
references: 18762023
references: Annu Rev Biochem. 2010;79:155-79
references: 20373914
references: Cell Metab. 2011 Apr 6;13(4):376-388
references: 21459323
references: Curr Biol. 2007 Jan 9;17(1):1-11
references: 17208179
references: Cell. 2012 Sep 14;150(6):1196-208
references: 22980980
references: Nat Rev Mol Cell Biol. 2009 May;10(5):307-18
references: 19339977
references: Genes Dev. 2008 Jan 15;22(2):239-51
references: 18198340
references: Cell Metab. 2008 Nov;8(5):411-24
references: 19046572
references: Nat Cell Biol. 2003 Jun;5(6):559-65
references: 12766775