title: Exploring mechanisms of FGF signalling through the lens of structural biology.
abstract: Fibroblast growth factors (FGFs) mediate a broad range of functions in both the developing and adult organism. The accumulated wealth of structural information on the FGF signalling pathway has begun to unveil the underlying molecular mechanisms that modulate this system to generate a myriad of distinct biological outputs in development, tissue homeostasis and metabolism. At the ligand and receptor level, these mechanisms include alternative splicing of the ligand (FGF8 subfamily) and the receptor (FGFR1-FGFR3), ligand homodimerization (FGF9 subfamily), site-specific proteolytic cleavage of the ligand (FGF23), and interaction of the ligand and the receptor with heparan sulphate cofactor and Klotho co-receptor.
authors: Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016, USA. Regina.Goetz@nyumc.org
authors: Regina
authors: R
authors: Goetz
authors: Moosa
authors: M
authors: Mohammadi
mesh_terms: D017398:Alternative Splicing; D051524:Fibroblast Growth Factor 8 / Q000235:genetics / Q000378:metabolism; D051525:Fibroblast Growth Factor 9 / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000737:chemistry / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism; D006497:Heparan Sulfate / Q000378:metabolism; D000090265:Klotho Proteins; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics / Q000378:metabolism; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics / Q000378:metabolism; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051524:Fibroblast Growth Factor 8; D051525:Fibroblast Growth Factor 9; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors; D005966:Glucuronidase; D006497:Heparan Sulfate; D000090265:Klotho Proteins; D051496:Receptor, Fibroblast Growth Factor, Type 1; D051497:Receptor, Fibroblast Growth Factor, Type 2; D051498:Receptor, Fibroblast Growth Factor, Type 3; D017468:Receptors, Fibroblast Growth Factor; C000717427:FGF23 protein, human; C496456:FGF8 protein, human; C496459:FGF9 protein, human; C496348:FGFR1 protein, human; C496353:FGFR2 protein, human; C496365:FGFR3 protein, human
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