title: The frequency of CD127(+) hepatitis C virus (HCV)-specific T cells but not the expression of exhaustion markers predicts the outcome of acute HCV infection.
abstract: T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this is the cause or consequence of HCV persistence. By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expression of the memory precursor marker CD127 on HCV-specific T cells, but not the expression of inhibitory molecules on those T cells or their ligands in the liver, predicts the outcome of acute infection.
authors: Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, USA.
authors: Eui-Cheol
authors: EC
authors: Shin
authors: Su-Hyung
authors: SH
authors: Park
authors: Michelina
authors: M
authors: Nascimbeni
authors: Marian
authors: M
authors: Major
authors: Laura
authors: L
authors: Caggiari
authors: Valli
authors: V
authors: de Re
authors: Stephen M
authors: SM
authors: Feinstone
authors: Charles M
authors: CM
authors: Rice
authors: Barbara
authors: B
authors: Rehermann
mesh_terms: D000818:Animals; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology / Q000662:veterinary*; D053699:Interleukin-7 Receptor alpha Subunit / Q000032:analysis*; D002679:Pan troglodytes; D018419:Primate Diseases / Q000276:immunology* / Q000821:virology; D016176:T-Lymphocyte Subsets / Q000737:chemistry / Q000276:immunology*
chemical_list: D053699:Interleukin-7 Receptor alpha Subunit
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