title: Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth.
abstract: OBJECTIVE
  To estimate the transmission of maternal vaginal microbiota to neonates during term delivery, focusing on Lactobacillus flora in relation to various obstetric clinical factors.
  
  
  METHODS
  Fifty consecutive pregnant healthy women with singleton term pregnancies and their newborn infants. Vertical transmission of Lactobacillus flora to the newborn during delivery was evaluated in 45 mother-newborn pairs.
  
  
  RESULTS
  Lactobacillus-dominant mixed flora was detected in 90% (N = 45) of vaginal samples, but only in 28% (N = 14) of neonatal cultures (transmission rate 31%). All neonates with Lactobacillus-dominant mixed flora had findings similar to those in maternal cultures. Cocci-dominant flora was the most common finding in neonates. Administration of antibiotics to the mother during the intrapartum period before birth and duration of rupture of membranes (ROM), regardless of maternal antibiotic treatment, were associated significantly with a decreased transmission rate of Lactobacillus-dominant mixed flora to neonates.
  
  
  CONCLUSIONS
  Maternal intrapartum antibiotics and prolonged expectant management after ROM were associated with decreased transmission rate of vaginal Lactobacillus flora to the neonate during birth. As early colonization of Lactobacillus flora may have a preventive role in the development of allergic diseases later, the significance of intrapartum prophylactic antibiotics needs to be highlighted in forthcoming studies, especially as regards immunological development of the offspring.
authors: Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland. leea.keski-nisula@kuh.fi
authors: Leea
authors: L
authors: Keski-Nisula
authors: Hanna-Reetta
authors: HR
authors: Kyynäräinen
authors: Ulla
authors: U
authors: Kärkkäinen
authors: Jari
authors: J
authors: Karhukorpi
authors: Seppo
authors: S
authors: Heinonen
authors: Juha
authors: J
authors: Pekkanen
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D019072:Antibiotic Prophylaxis / Q000009:adverse effects*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D007778:Lactobacillus; D008297:Male; D009055:Mouth / Q000382:microbiology; D036801:Parturition; D011247:Pregnancy; D011446:Prospective Studies; D014621:Vagina / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents