title: Effects of AKAP5 Pro100Leu genotype on working memory for emotional stimuli.
abstract: Recent investigations addressing the role of the synaptic multiadaptor molecule AKAP5 in human emotion and behavior suggest that the AKAP5 Pro100Leu polymorphism (rs2230491) contributes to individual differences in affective control. Carriers of the less common Leu allele show a higher control of anger as indicated by behavioral measures and dACC brain response on emotional distracters when compared to Pro homozygotes. In the current fMRI study we used an emotional working memory task according to the n-back scheme with neutral and negative emotional faces as target stimuli. Pro homozygotes showed a performance advantage at the behavioral level and exhibited enhanced activation of the amygdala and fusiform face area during working memory for emotional faces. On the other hand, Leu carriers exhibited increased activation of the dACC during performance of the 2-back condition. Our results suggest that AKAP5 Pro100Leu effects on emotion processing might be task-dependent with Pro homozygotes showing lower control of emotional interference, but more efficient processing of task-relevant emotional stimuli.
authors: Department of Clinical Psychology, University of Salzburg, Salzburg, Austria.
authors: Sylvia
authors: S
authors: Richter
authors: Xenia
authors: X
authors: Gorny
authors: Judith
authors: J
authors: Machts
authors: Gusalija
authors: G
authors: Behnisch
authors: Torsten
authors: T
authors: Wüstenberg
authors: Maike C
authors: MC
authors: Herbort
authors: Thomas F
authors: TF
authors: Münte
authors: Constanze I
authors: CI
authors: Seidenbecher
authors: Björn H
authors: BH
authors: Schott
mesh_terms: D054758:A Kinase Anchor Proteins / Q000235:genetics*; D000328:Adult; D001921:Brain / Q000502:physiology; D001931:Brain Mapping; D004644:Emotions / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D010775:Photic Stimulation; D055815:Young Adult
chemical_list: D054758:A Kinase Anchor Proteins; C487775:AKAP5 protein, human
references: Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9827-32
references: 15210952
references: Front Hum Neurosci. 2011 Dec 29;5:175
references: 22232585
references: J Neurosci. 1998 Jan 1;18(1):411-8
references: 9412517
references: Eur J Neurosci. 2006 Aug;24(4):1227-36
references: 16930447
references: Emotion. 2003 Dec;3(4):378-93
references: 14674830
references: Trends Neurosci. 2008 Mar;31(3):120-9
references: 18258310
references: Curr Opin Neurobiol. 2004 Apr;14(2):139-47
references: 15082317
references: Neuroimage. 2010 Nov 15;53(3):870-7
references: 20060913
references: J Psychiatry Neurosci. 2009 Jan;34(1):30-40
references: 19125211
references: Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12557-62
references: 18711127
references: Nat Neurosci. 2003 Nov;6(11):1141-2
references: 14566344
references: Neuropharmacology. 2004 Oct;47(5):764-78
references: 15458848
references: Philos Trans R Soc Lond B Biol Sci. 2011 Jun 12;366(1571):1684-701
references: 21536554
references: Neuroimage. 2009 Sep;47(3):836-51
references: 19465135
references: Nat Neurosci. 2008 Dec;11(12):1381-2
references: 18978778
references: Neuropsychologia. 2010 Oct;48(12):3596-605
references: 20727365
references: Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6269-74
references: 16569698
references: Emotion. 2009 Jun;9(3):385-96
references: 19485616
references: Biol Psychol. 2008 Sep;79(1):30-42
references: 18178303
references: Neuroimage. 2010 Nov 15;53(3):943-51
references: 19969089
references: PLoS One. 2009;4(8):e6726
references: 21949675
references: Psychopharmacology (Berl). 2008 Mar;197(1):127-36
references: 18046544
references: Neuroimage. 1997 Jan;5(1):49-62
references: 9038284
references: J Psychiatry Neurosci. 2004 May;29(3):174-84
references: 15173894
references: Nat Rev Neurosci. 2006 Oct;7(10):818-27
references: 16988657
references: Trends Cogn Sci. 2005 May;9(5):242-9
references: 15866151
references: Annu Rev Neurosci. 2009;32:225-47
references: 19400720
references: Neuroscience. 2009 Nov 24;164(1):43-54
references: 19559759
references: Microsc Res Tech. 1999 Jul 1;46(1):48-52
references: 10402271
references: Trends Cogn Sci. 2011 Sep;15(9):381-7
references: 21835680
references: Nat Neurosci. 2005 Jun;8(6):828-34
references: 15880108
references: EMBO J. 2006 Dec 13;25(24):5864-72
references: 17110924
references: Science. 2002 Jul 19;297(5580):400-3
references: 12130784
references: J Biol Chem. 2006 Nov 3;281(44):33537-53
references: 16940053
references: Neuroimage. 2008 Jun;41(2):544-52
references: 18396414
references: Cogn Psychol. 1997 Jun;33(1):5-42
references: 9212720
references: Nat Neurosci. 2005 Jan;8(1):20-1
references: 15592465
references: Biol Psychiatry. 2007 Feb 15;61(4):512-20
references: 17069771
references: Mol Psychiatry. 2012 Mar;17(3):337-49
references: 21173776
references: J Neurosci. 2005 Jan 26;25(4):836-42
references: 15673663
references: Am J Psychiatry. 2011 Sep;168(9):979-85
references: 21724666
references: J Neurosci. 2007 Dec 5;27(49):13393-401
references: 18057197
references: J Neurosci. 2010 Oct 20;30(42):14205-12
references: 20962241
references: Hum Brain Mapp. 2013 Feb;34(2):407-24
references: 22042493
references: J Neurosci. 2010 Dec 1;30(48):16324-31
references: 21123578
references: Rev Neurosci. 2006;17(3):359-67
references: 16878403
references: Arch Gen Psychiatry. 2008 May;65(5):568-76
references: 18458208
references: Gastroenterology. 2011 Jun;140(7):1943-51
references: 21420406
references: J Neurosci. 2009 Jan 28;29(4):1132-9
references: 19176822
references: Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12604-9
references: 15310849
references: Front Hum Neurosci. 2011 Nov 17;5:144
references: 22125521
references: Neuroreport. 2002 Oct 7;13(14):1737-41
references: 12395114
references: Biol Psychol. 2011 Apr;87(1):106-12
references: 21356267
references: PLoS One. 2010 Mar 22;5(3):e9790
references: 20339549
references: Mol Psychiatry. 2009 Jan;14(1):60-70
references: 17893706
references: Cereb Cortex. 2008 Nov;18(11):2686-700
references: 18372293
references: J Psychiatry Neurosci. 2009 Nov;34(6):418-32
references: 19949718
references: Trends Cogn Sci. 2006 Apr;10(4):182-91
references: 16530463
references: Cells Tissues Organs. 2001;168(4):319-29
references: 11275698
references: Brain. 2000 Nov;123 ( Pt 11):2203-12
references: 11050021
references: Neuroimage. 2012 May 1;60(4):2222-9
references: 22387174
references: Soc Cogn Affect Neurosci. 2008 Jun;3(2):119-27
references: 19015102
references: Hum Brain Mapp. 2005 May;25(1):46-59
references: 15846822
references: Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13626-31
references: 14595032
references: J Cogn Neurosci. 2011 Nov;23(11):3681-93
references: 21568644
references: Brain. 1998 Jan;121 ( Pt 1):47-57
references: 9549487
references: Acta Neurobiol Exp (Wars). 2008;68(2):229-52
references: 18511959
references: Eur J Neurosci. 2000 Apr;12(4):1155-64
references: 10762347
references: Neuroimage. 2007 Aug 15;37(2):623-32
references: 17570686
references: PLoS One. 2009 Jun 22;4(6):e5952
references: 19543398
references: Science. 2002 Jun 21;296(5576):2191
references: 12077407
references: J Neurosci. 2008 Dec 24;28(52):14311-9
references: 19109512
references: Neuron. 2001 Jun;30(3):829-41
references: 11430815
references: Neuropsychologia. 2007 Jan 7;45(1):174-94
references: 16854439
references: Nat Neurosci. 2002 Sep;5(9):837-8
references: 12172550
references: Curr Opin Neurobiol. 2010 Apr;20(2):242-50
references: 20381337
references: Hum Mol Genet. 2006 Mar 1;15(5):743-9
references: 16434481
references: Mol Psychiatry. 2006 Sep;11(9):867-77, 797
references: 16786032
references: Emotion. 2009 Dec;9(6):855-64
references: 20001128
references: Brain Res Cogn Brain Res. 2001 Jan;10(3):355-64
references: 11167061