title: Circulating TNF receptor 2 is associated with the development of chronic kidney disease in non-obese Japanese patients with type 2 diabetes.
abstract: OBJECTIVE
  Chronic low-grade inflammation and/or obesity are suggested to induce chronic kidney disease (CKD) in patients with type 2 diabetes. This cross-sectional study was performed to investigate the relationship between inflammatory biomarkers and CKD in non-obese patients with type 2 diabetes.
  
  
  METHODS
  106 non-obese Japanese patients with type 2 diabetes were recruited for the measurement of GFR, TNF, HMW adiponectin, leptin, hsCRP and some variables including urinary albumin. BMI, serum creatinine, and urinary albumin levels were 22.2 ± 0.2 kg/m(2) (17.1-24.9 kg/m(2)), 0.76 ± 0.02 mg/dl (0.39-1.38 mg/dl), 40.4 ± 4.3mg/gCr (1.6-195.0mg/gCr), respectively. They were stratified into two groups based on the value of eGFR: low eGFR (eGFR<60 ml/min/1.73 m(2)) and normal eGFR (eGFR>60 ml/min/1.73 m(2)). Logistic regression analysis was used for statistical analysis.
  
  
  RESULTS
  Whereas univariate logistic regression analysis showed that gender, diabetes duration, triglyceride, HDL cholesterol, uric acid, urinary albumin, and soluble TNF receptors (sTNF-R1, sTNF-R2) are associated with the development of stage 3 CKD, multivariate logistic regression analysis revealed that sTNF-R2 (Odds ratio 1.003, 95% confidence interval 1.000 to 1.005, P=0.030) showed significant associations with the development of stage 3 CKD.
  
  
  CONCLUSIONS
  Circulating TNF receptor 2 is an independent risk factor for CKD in non-obese Japanese patients with type 2 diabetes.
authors: Department of Internal Medicine, Osaka North Postal Services Agency Hospital, Osaka, Japan.
authors: Yoshio
authors: Y
authors: Izumi
authors: Daisuke
authors: D
authors: Yabe
authors: Ataru
authors: A
authors: Taniguchi
authors: Mitsuo
authors: M
authors: Fukushima
authors: Yoshikatsu
authors: Y
authors: Nakai
authors: Masaya
authors: M
authors: Hosokawa
authors: Takahide
authors: T
authors: Okumura
authors: Kazuko
authors: K
authors: Nin
authors: Kazunari
authors: K
authors: Matsumoto
authors: Fusanori
authors: F
authors: Nishimura
authors: Shoichiro
authors: S
authors: Nagasaka
authors: Yutaka
authors: Y
authors: Seino
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D044466:Asian People; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000097:blood*
chemical_list: D052242:Adiponectin; D020738:Leptin; D018124:Receptors, Tumor Necrosis Factor; D003404:Creatinine