title: Comparison of immune response by virus infection and vaccination to 2009 pandemic influenza A/H1N1 in children.
abstract: We aimed to compare the immune response induced by natural infection with 2009 pandemic influenza A/H1N1 (pH1N1) virus and by monovalent pH1N1 vaccination in children and adolescents. This cross-sectional clinical study was conducted at 3 hospitals in Korea from February to May 2010. A total of 266 healthy subjects aged from 6 months to 18 yr were tested for the presence of the antibody against pH1N1 using hemagglutination inhibition (HI) test. Information about pH1N1 vaccination and laboratory-confirmed pH1N1 infection history was obtained. The overall rate of HI titers of ≥ 1:40 against pH1N1 was 38.7%, and the geometric mean titer (GMT) was 20.5. Immunogenicity of pH1N1 vaccination only was reflected by a 41.1% of seroprotection rate and a GMT of 22.5. Immunogenicity of natural infection only was reflected by a 61.0% of seroprotection rate and a GMT of 40.0. GMT was significantly higher in the subjects of natural infection group than in the subjects of pH1N1 vaccination group (P < 0.001). The immune responses induced by natural pH1N1 infection exceed those induced by pH1N1 vaccinations.
authors: Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea.
authors: Eun Kyeong
authors: EK
authors: Kang
authors: Jung Sub
authors: JS
authors: Lim
authors: Jun Ah
authors: JA
authors: Lee
authors: Dong Ho
authors: DH
authors: Kim
mesh_terms: D000293:Adolescent; D057134:Antibodies, Neutralizing / Q000097:blood; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology* / Q000378:metabolism; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D058873:Pandemics; D014611:Vaccination
chemical_list: D057134:Antibodies, Neutralizing
keywords: Child; Immune Response; Natural Infection; Pandemic Influenza A; Vaccination
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