title: Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles.
abstract: The present work deals with the preparation, characterization and evaluation of glutaraldehyde cross-linked chitosan-tamarind seed polysaccharide (TSP) interpenetrating polymeric network (IPN) microparticles for prolonged aceclofenac release. The drug entrapment efficiency of these microparticles was found 85.84±1.75 to 91.97±1.30% and their average particle sizes were ranged from 490.55±23.24 to 621.60±53.57 μm. These chitosan-TSP IPN microparticles were characterized by FTIR, DSC, and SEM analyses. The in vitro drug release from these aceclofenac-loaded chitosan-TSP IPN microparticles showed sustained release of aceclofenac over 8h and followed the Korsmeyer-Peppas model (R(2)=0.9809-0.9828) with anomalous (non-Fickian) diffusion drug release mechanism. The in vivo studies exhibited sustained anti-inflammatory activity in carrageenan-induced rats over prolonged period after oral administration of these newly developed aceclofenac-loaded IPN microparticles.
authors: Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, WB, India. janapharmacy@rediffmail.com
authors: Sougata
authors: S
authors: Jana
authors: Abhimunya
authors: A
authors: Saha
authors: Amit Kumar
authors: AK
authors: Nayak
authors: Kalyan Kumar
authors: KK
authors: Sen
authors: Sanat Kumar
authors: SK
authors: Basu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D002351:Carrageenan / Q000633:toxicity; D048271:Chitosan / Q000737:chemistry*; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000494:pharmacology; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005976:Glutaral / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008863:Microspheres; D011108:Polymers / Q000737:chemistry*; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D029861:Tamarindus / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011108:Polymers; D011134:Polysaccharides; D004008:Diclofenac; D002351:Carrageenan; D048271:Chitosan; C056498:aceclofenac; D005976:Glutaral