title: Adolescent transformations of behavioral and neural processes as potential targets for prevention.
abstract: Adolescence is a transitional period in development that is marked by a distinct, typical behavioral profile of high rates of exploration, novelty-seeking, and emotional lability. While these behaviors generally assist the adolescent transition to independence, they can also confer vulnerability for excessive risk-taking and psychopathology, particularly in the context of specific environmental or genetic influences. As prevention research depends on the identification of targets of vulnerability, the following review will discuss the interplay among motivational systems including reward-related, avoidance-related, and regulatory processes in typical and atypical adolescent development. Each set of processes will be discussed in relation to their underlying neural correlates and distinct developmental trajectories. Evidence suggests that typical adolescent behavior and the risk for atypical development are mediated by heightened adolescent responsiveness of reward-related and avoidance-related systems under specific conditions, concurrent with poor modulation by immature regulatory processes. Finally, we will propose strategies to exploit heightened reward processing to reinforce inhibitory control, which is an essential component of regulatory processes in prevention interventions.
authors: Molecular Epidemiology, Genomics, Environment and Health, RTI International, Baltimore, MD, USA.
authors: Dana
authors: D
authors: Eldreth
authors: Michael G
authors: MG
authors: Hardin
authors: Nevia
authors: N
authors: Pavletic
authors: Monique
authors: M
authors: Ernst
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D001362:Avoidance Learning; D002490:Central Nervous System / Q000502:physiology*; D006801:Humans; D009042:Motivation; D011315:Preventive Medicine
references: Hum Brain Mapp. 2009 Jan;30(1):163-74
references: 18041741
references: J Child Psychol Psychiatry. 2009 Dec;50(12):1550-8
references: 19573033
references: J Neurosci. 2007 May 2;27(18):4826-31
references: 17475790
references: Psychol Med. 2005 Feb;35(2):163-74
references: 15841674
references: Dev Sci. 2005 Jan;8(1):74-87
references: 15647068
references: Neuroimage. 2006 May 15;31(1):397-409
references: 16414281
references: Neuropsychopharmacology. 2010 Jan;35(1):4-26
references: 19812543
references: Brain Cogn. 2010 Feb;72(1):124-33
references: 19695759
references: J Cogn Neurosci. 2007 Jan;19(1):69-80
references: 17214564
references: Neuroimage. 2007;36 Suppl 2:T54-60
references: 17499170
references: Brain Cogn. 2008 Dec;68(3):293-308
references: 18938009
references: Child Dev. 2009 Jan-Feb;80(1):28-44
references: 19236391
references: Neuropsychologia. 2006;44(11):2149-57
references: 16303150
references: Nat Rev Neurosci. 2004 Mar;5(3):218-28
references: 14976521
references: Neurosci Biobehav Rev. 2000 Jun;24(4):417-63
references: 10817843
references: Child Dev. 2004 Sep-Oct;75(5):1357-72
references: 15369519
references: Neuron. 2002 Jan 17;33(2):301-11
references: 11804576
references: Exp Brain Res. 2006 Oct;174(4):754-62
references: 16733706
references: Ann N Y Acad Sci. 2004 Jun;1021:294-5
references: 15251899
references: Brain Res Rev. 2008 Jun;58(1):57-70
references: 18076995
references: Biol Psychiatry. 2004 Feb 15;55(4):359-66
references: 14960288
references: Psychol Bull. 2000 Mar;126(2):220-46
references: 10748641
references: Trends Cogn Sci. 2004 Apr;8(4):170-7
references: 15050513
references: Nat Rev Neurosci. 2004 Jun;5(6):483-94
references: 15152198
references: J Neurophysiol. 2001 Mar;85(3):1315-21
references: 11248000
references: J Adolesc Health. 2002 Dec;31(6 Suppl):175-84
references: 12470913
references: Cereb Cortex. 2010 Jul;20(7):1613-29
references: 19875675
references: Psychopharmacology (Berl). 2011 Mar;214(1):17-31
references: 20596857
references: J Child Psychol Psychiatry. 2012 Aug;53(8):856-63
references: 22409260
references: Neurosci Biobehav Rev. 2009 Mar;33(3):367-82
references: 19028521
references: Science. 2005 Mar 11;307(5715):1642-5
references: 15761155
references: Drug Alcohol Depend. 2004 Jun 11;74(3):223-34
references: 15194200
references: Biol Psychiatry. 2005 Oct 15;58(8):632-9
references: 16018983
references: Curr Opin Neurobiol. 2004 Apr;14(2):148-55
references: 15082318
references: Neuroimage. 2003 Feb;18(2):263-72
references: 12595181
references: J Am Acad Child Adolesc Psychiatry. 2006 Apr;45(4):468-75
references: 16601652
references: Neuropsychopharmacology. 2010 Jan;35(1):27-47
references: 19675534
references: Neuron. 2001 Dec 6;32(5):927-46
references: 11738036
references: J Neurosci. 2004 Feb 25;24(8):1793-802
references: 14985419
references: J Am Acad Child Adolesc Psychiatry. 2002 Oct;41(10):1231-8
references: 12364845
references: Drug Alcohol Depend. 2008 Jun 1;95 Suppl 1:S29-44
references: 18249508
references: J Cogn Neurosci. 2008 Sep;20(9):1565-82
references: 18345988
references: Clin Psychol Rev. 2011 Feb;31(1):138-45
references: 20817334
references: J Neurophysiol. 2000 Dec;84(6):3072-7
references: 11110834
references: Dev Psychopathol. 2008 Fall;20(4):1191-211
references: 18838038
references: Drug Alcohol Depend. 2008 Jun 1;95 Suppl 1:S5-S28
references: 18343607
references: Brain Cogn. 2004 Nov;56(2):129-40
references: 15518930
references: Neuroscientist. 2007 Jun;13(3):214-28
references: 17519365
references: Brain Res. 1997 Apr 18;754(1-2):285-97
references: 9134986
references: Nat Rev Neurosci. 2008 Dec;9(12):947-57
references: 19002191
references: Psychol Med. 2006 Mar;36(3):299-312
references: 16472412
references: J Neurosci. 2006 Jun 14;26(24):6399-405
references: 16775126
references: Prev Sci. 2000 Jun;1(2):89-106
references: 11521962
references: Neurosci Biobehav Rev. 2006;30(6):718-29
references: 16887188
references: J Neurosci. 2006 Mar 1;26(9):2424-33
references: 16510720
references: Arch Gen Psychiatry. 2005 Jun;62(6):593-602
references: 15939837
references: J Child Psychol Psychiatry. 2007 May;48(5):446-54
references: 17501725
references: Hum Brain Mapp. 2001 Feb;12(2):100-9
references: 11169874
references: J Neurosci. 2006 Jun 21;26(25):6885-92
references: 16793895
references: Hum Brain Mapp. 2004 Oct;23(2):99-108
references: 15340932
references: Arch Gen Psychiatry. 2012 Apr;69(4):372-80
references: 22147808
references: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8301-6
references: 10393989
references: Alcohol. 2010 Feb;44(1):67-80
references: 20113875
references: J Res Adolesc. 2007 Sep;17(3):587-600
references: 18461148
references: Cereb Cortex. 2006 Apr;16(4):553-60
references: 16033925
references: Neuroimage. 2001 Feb;13(2):250-61
references: 11162266
references: Dev Psychol. 2010 Jan;46(1):193-207
references: 20053017
references: Am J Psychiatry. 2012 Feb;169(2):205-12
references: 22423352
references: Vision Res. 1978;18(10):1279-96
references: 726270
references: J Neurosci. 2003 Aug 27;23(21):7931-9
references: 12944524
references: Trends Neurosci. 2008 Mar;31(3):120-9
references: 18258310
references: Drug Alcohol Depend. 2006 Mar 15;82(1):47-60
references: 16154296
references: J Cogn Neurosci. 2006 Mar;18(3):444-55
references: 16513008
references: PLoS One. 2010 Jul 06;5(7):e11440
references: 20625430
references: Front Hum Neurosci. 2010 Feb 12;4:6
references: 20179786
references: Psychol Bull. 2007 Jan;133(1):1-24
references: 17201568
references: Neuroimage. 2005 May 1;25(4):1279-91
references: 15850746
references: Dev Rev. 2008;28(1):62-77
references: 18688292
references: Trends Cogn Sci. 2005 Feb;9(2):69-74
references: 15668099
references: Nat Neurosci. 2001 Jan;4(1):95-102
references: 11135651
references: Behav Res Ther. 1998 Sep;36(9):809-48
references: 9701859
references: Hum Brain Mapp. 2007 Nov;28(11):1163-77
references: 17538951
references: Neuroimage. 2003 Sep;20(1):351-8
references: 14527595
references: Emotion. 2007 May;7(2):336-53
references: 17516812
references: Perspect Sex Reprod Health. 2006 Jun;38(2):90-6
references: 16772190
references: Neuroscientist. 2004 Jun;10(3):260-8
references: 15155064
references: Child Dev. 2003 Nov-Dec;74(6):1869-80
references: 14669901
references: Prev Sci. 2006 Mar;7(1):91-102
references: 16572300
references: J Child Psychol Psychiatry. 1994 Feb;35(2):259-81
references: 8188798
references: Neuroinformatics. 2006 Winter;4(1):51-64
references: 16595858
references: J Neurosci. 2003 Jan 1;23(1):303-7
references: 12514228
references: Annu Rev Neurosci. 2000;23:155-84
references: 10845062
references: MMWR Surveill Summ. 2006 Jun 9;55(5):1-108
references: 16760893
references: Trends Cogn Sci. 2005 Feb;9(2):60-8
references: 15668098
references: Child Dev. 2002 Jul-Aug;73(4):1151-65
references: 12146740
references: Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4119-24
references: 9108115
references: Dev Psychol. 2008 Nov;44(6):1764-78
references: 18999337