title: Toward identifying the effects of the specific components of Mindfulness-Based Stress Reduction on biologic and emotional outcomes among older adults.
abstract: OBJECTIVE
  The objectives of this study were to examine the effects of specific Mindfulness-Based Stress Reduction (MBSR) activities (yoga, sitting and informal meditation, body scan) on immune function, circulating insulin-like growth factor (IGF)-1 concentrations, and positive affect among older adults.
  
  
  METHODS
  The study design comprised longitudinal analyses of data from subjects in an 8-week MBSR program.
  
  
  METHODS
  The study was conducted at a University-affiliated health center.
  
  
  METHODS
  This study involved 100 community-dwelling older adults. Inclusion criteria were as follows: ≥65 years of age and English-speaking.
  
  
  METHODS
  This was an 8-week MBSR program.
  
  
  METHODS
  Interleukin (IL)-6 and IGF-1 levels were assayed from blood collected at postintervention assessments. Participants were immunized postintervention with keyhole limpet hemocyanin (KLH), and immunoglobulin (Ig)M and IgG KLH-specific antibody responses were measured prior to immunization as well as 3 weeks and 24 weeks postintervention. Participants completed a 10-item measure of positive affect at study entry and postintervention.
  
  
  RESULTS
  Participants maintained weekly practice logs documenting participation in yoga, sitting meditation, informal meditation, and body scan. More practice of yoga was associated with higher post-treatment IGF-1 levels and greater improvement in positive affect from study entry to postintervention. Sitting meditation was positively associated with post-treatment IGF-1. Greater use of body scanning was associated with reduced antigen-specific IgM and IgG 3 weeks postintervention but not 24 weeks. No associations were found between MBSR activities and IL-6 levels.
  
  
  CONCLUSIONS
  Practice of MBSR activities, particularly yoga, could provide benefits for specific aspects of physiologic function and positive affect. Changes in adaptive immunity in older adult MBSR practitioners warrant further study.
authors: 1 Rochester Center for Mind-Body Research, Department of Psychiatry, University of Rochester Medical Center , Rochester, NY.
authors: Autumn M
authors: AM
authors: Gallegos
authors: Michael
authors: M
authors: Hoerger
authors: Nancy L
authors: NL
authors: Talbot
authors: Michael S
authors: MS
authors: Krasner
authors: Jennifer M
authors: JM
authors: Knight
authors: Jan A
authors: JA
authors: Moynihan
authors: Paul R
authors: PR
authors: Duberstein
mesh_terms: D056704:Adaptive Immunity; D000368:Aged; D004644:Emotions; D005260:Female; D006433:Hemocyanins / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D019122:Meditation; D026441:Mind-Body Therapies; D064866:Mindfulness; D013315:Stress, Psychological / Q000276:immunology* / Q000517:prevention & control*; D016896:Treatment Outcome; D015013:Yoga
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015850:Interleukin-6; D007334:Insulin-Like Growth Factor I; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin
references: Psychosom Med. 2010 Feb;72(2):113-21
references: 20064902
references: J Am Geriatr Soc. 2007 Apr;55(4):511-7
references: 17397428
references: Growth Horm IGF Res. 2005 Dec;15(6):416-22
references: 16256385
references: Curr Opin Immunol. 2009 Apr;21(2):153-60
references: 19375293
references: Psychoneuroendocrinology. 2011 Jun;36(5):664-81
references: 21035949
references: J Altern Complement Med. 2010 May;16(5):531-8
references: 20455784
references: Psychosom Med. 2003 Jul-Aug;65(4):564-70
references: 12883106
references: Brain Behav Immun. 1999 Jun;13(2):93-108
references: 10373275
references: J Psychosom Res. 2010 Jan;68(1):29-36
references: 20004298
references: J Clin Psychol. 2009 Jun;65(6):613-26
references: 19267330
references: Psychol Bull. 2010 Nov;136(6):1068-91
references: 21038939
references: Psychosom Med. 2002 Jan-Feb;64(1):71-83
references: 11818588
references: J Clin Psychol. 2008 Jul;64(7):840-62
references: 18484600
references: J Psychiatr Res. 1975 Nov;12(3):189-98
references: 1202204
references: Brain Behav Immun. 2007 Nov;21(8):1038-49
references: 17521871
references: J Behav Med. 2006 Aug;29(4):389-400
references: 16715331
references: Clin Immunol Immunopathol. 1994 Jul;72(1):30-4
references: 8020191
references: Altern Ther Health Med. 2004 Mar-Apr;10(2):20-1
references: 15055088
references: Cell Res. 2010 Jan;20(1):4-12
references: 20010916
references: J Pers Soc Psychol. 1988 Jun;54(6):1063-70
references: 3397865
references: Brain Behav Immun. 2010 Nov;24(8):1294-300
references: 20600815
references: J Consult Clin Psychol. 2008 Jun;76(3):408-421
references: 18540734
references: Brain Behav Immun. 2004 Jan;18(1):65-75
references: 14651948
references: Gerontologist. 2008 Apr;48(2):135-41
references: 18483425
references: J Gerontol B Psychol Sci Soc Sci. 2010 Mar;65B(2):135-44
references: 20054013
references: AIDS. 2000 Jan 7;14(1):11-21
references: 10714563
references: Ann N Y Acad Sci. 2009 Aug;1172:34-53
references: 19735238
references: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9090-5
references: 12840146
references: J Altern Complement Med. 2003 Oct;9(5):683-94
references: 14629846
references: BMJ. 2001 Dec 22-29;323(7327):1446-9
references: 11751348
references: Mech Ageing Dev. 2007 Jan;128(1):92-105
references: 17116321
references: J Comp Pathol. 2010 Jan;142 Suppl 1:S39-44
references: 19897208
references: Brain Behav Immun. 2008 Aug;22(6):969-81
references: 18359186
references: Emotion. 2010 Feb;10(1):54-64
references: 20141302
references: Mech Ageing Dev. 2005 Feb;126(2):351-61
references: 15621218
references: J Behav Med. 2008 Feb;31(1):23-33
references: 17899351
references: Psychosom Med. 2000 Sep-Oct;62(5):613-22
references: 11020090