title: SurfaceomeDB: a cancer-orientated database for genes encoding cell surface proteins.
abstract: Cell surface proteins (CSPs) are excellent targets for the development of diagnostic and therapeutic reagents, and it is estimated that 10-20% of all genes in the human genome encode CSPs. In an effort to integrate all data publicly available for genes encoding cell surface proteins, a database (SurfaceomeDB) was developed. SurfaceomeDB is a gene-centered portal containing different types of information, including annotation for gene expression, protein domains, somatic mutations in cancer, and protein-protein interactions for all human genes encoding CSPs. SurfaceomeDB was implemented as an integrative and relational database in a user-friendly web interface, where users can search for gene name, gene annotation, or keywords. There is also a streamlined graphical representation of all data provided and links to the most important data repositories and databases, such as NCBI, UCSC Genome Browser, and EBI.
authors: Ludwig Institute for Cancer Research, São Paulo Branch at Hospital Alemão Oswaldo Cruz, São Paulo, Brazil.
authors: Jorge Estefano Santana
authors: JE
authors: de Souza
authors: Pedro Alexandre Favoretto
authors: PA
authors: Galante
authors: Renan Valieris Bueno
authors: RV
authors: de Almeida
authors: Julia Pinheiro Chagas
authors: JP
authors: da Cunha
authors: Daniel Takatori
authors: DT
authors: Ohara
authors: Lucila
authors: L
authors: Ohno-Machado
authors: Lloyd J
authors: LJ
authors: Old
authors: Sandro José
authors: SJ
authors: de Souza
mesh_terms: D030541:Databases, Genetic; D015894:Genome, Human; D023281:Genomics / Q000379:methods; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*
chemical_list: D008565:Membrane Proteins
keywords: SurfaceomeDB; cell surface proteins; gene library
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