title: Detection and size measurement of individual hemozoin nanocrystals in aquatic environment using a whispering gallery mode resonator.
abstract: We, for the first time, report the detection and the size measurement of single nanoparticles (i.e. polystyrene) in aquatic environment using mode splitting in a whispering gallery mode (WGM) optical resonator, namely a microtoroid resonator. Using this method we achieved detecting and measuring individual synthetic hemozoin nanocrystals--a hemoglobin degradation by-product of malarial parasites--dispersed in a solution or in air. The results of size measurement in solution and in air agree with each other and with those obtained using scanning electron microscope and dynamic light scattering. Moreover, we compare the sensing capabilities of the degenerate (single resonance) and non-degenerate (split mode, doublet) operation regimes of the WGM resonator.
authors: Department of Electrical and Systems Engineering, Washington University, St. Louis, MO 63130, USA. woosung.kim@go.wustl.edu
authors: Woosung
authors: W
authors: Kim
authors: Sahin Kaya
authors: SK
authors: Ozdemir
authors: Jiangang
authors: J
authors: Zhu
authors: Monifi
authors: M
authors: Faraz
authors: Cevayir
authors: C
authors: Coban
authors: Lan
authors: L
authors: Yang