title: Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B.
abstract: A methanolic extract and its ethyl acetate-soluble fraction from Sri Lankan curry-leaf, the leaves of Murraya koenigii, inhibited melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Two new carbazole alkaloids, karapinchamines A and B, were isolated from the ethyl acetate-soluble fraction together with 12 known carbazole alkaloids. The structures of karapinchamines A and B were determined by physicochemical analyses. The principal alkaloid constituents were found to display potent melanogenesis inhibitory activity. The structural requirements of the carbazole alkaloids for melanogenesis inhibitory activity were discussed.
authors: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Kyoto 607-8412, Japan.
authors: Seikou
authors: S
authors: Nakamura
authors: Souichi
authors: S
authors: Nakashima
authors: Yoshimi
authors: Y
authors: Oda
authors: Nami
authors: N
authors: Yokota
authors: Katsuyoshi
authors: K
authors: Fujimoto
authors: Takahiro
authors: T
authors: Matsumoto
authors: Tomoe
authors: T
authors: Ohta
authors: Keiko
authors: K
authors: Ogawa
authors: Sayuri
authors: S
authors: Maeda
authors: Shino
authors: S
authors: Nishida
authors: Hisashi
authors: H
authors: Matsuda
authors: Masayuki
authors: M
authors: Yoshikawa
mesh_terms: D000085:Acetates / Q000737:chemistry; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002227:Carbazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D005591:Chemical Fractionation; D005786:Gene Expression Regulation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000378:metabolism; D051379:Mice; D008968:Molecular Conformation; D032101:Murraya / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000085:Acetates; D000470:Alkaloids; D002227:Carbazoles; D008543:Melanins; D010936:Plant Extracts; C582991:karapinchamine A; C582992:karapinchamine B; C007650:ethyl acetate