title: Highly discriminating photorelease of anticancer drugs based on hypoxia activatable phototrigger conjugated chitosan nanoparticles.
abstract: An ultimately selective photorelease system of chitosan-nanoparticles is constructed. Only under unique aspects of tumor-hypoxia physiological conditions, the preliminary locked phototrigger is unlocked by biological reduction to enable the release of the caged drug either by visible light or two-photon near-IR (NIR) excitation. This approach provides a highly discriminating photorelease of anticancer drug to hypoxic tumor cells, but not to healthy normal cells.
authors: Shanghai Key Laboratory of Functional, Materials Chemistry, Fine Chemicals, East China University of Science and Technology, Shanghai, China.
authors: Qiuning
authors: Q
authors: Lin
authors: Chunyan
authors: C
authors: Bao
authors: Yunlong
authors: Y
authors: Yang
authors: Qiannan
authors: Q
authors: Liang
authors: Dasheng
authors: D
authors: Zhang
authors: Shuiyu
authors: S
authors: Cheng
authors: Linyong
authors: L
authors: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity*; D015687:Cell Hypoxia / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008027:Light; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017785:Photons
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D048271:Chitosan