title: The effects of DEX premedication on volatile induction of mask anesthesia (VIMA) and sevoflurane requirements.
abstract: We investigated the effect of intravenous premedication with single dose of dexmedetomidine (DEX) on volatile anesthetic induction time and sevoflurane requirements of anesthesia maintenance in adults by monitoring the bispectral index (BIS). Sixty adult patients with status of ASA I-II undergoing general anesthesia with endotracheal intubation were randomly divided into two groups: The first group; a control group (group C, n = 30) and the second group; DEX group (group D, n = 30). Each patient in group D was premedicated with intravenous DEX 0.5 μg/kg or placebo 10 min before the induction of anesthesia. Anesthesia was induced by fentanyl 1 μg/kg, 1:1 ratio of nitrous oxide and oxygen and sevoflurane of 5-8 % and rocuronium bromur (Esmeron) 0.5 mg/kg keeping BIS values at 40-50. Time to induction of anesthesia, BIS, End-tidal sevoflurane concentration (Etsevoflurane), End-tidal CO2 concentration, duration of surgery, recovery time, hemodynamic variables, adverse effects were recorded intraoperatively. Analgesic requirement was noted in postoperative 24 h-period. The time to induction of anesthesia (p < 0.0001) and Etsevoflurane at 1 min (p < 0.05) were significantly lower in group D than in group C. Intravenous premedication with 0.5 μg/kg of DEX decreased the induction time by almost 75 % and provided a significant decrease in Etsevoflurane.
authors: Department of Anesthesiology and Reanimation, Gaziantep University Medical Faculty, School of Medicine, Gaziantep University, 27310 Sahinbey, Gaziantep, Turkey. aysemizrak@mynet.com
authors: Ayse
authors: A
authors: Mizrak
authors: Suleyman
authors: S
authors: Ganidagli
authors: Mehri T
authors: MT
authors: Cengiz
authors: Unsal
authors: U
authors: Oner
authors: Vahap
authors: V
authors: Saricicek
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage; D000328:Adult; D000769:Anesthesia, Inhalation / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D056805:Consciousness Monitors; D020927:Dexmedetomidine / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D011292:Premedication / Q000379:methods*; D000077149:Sevoflurane
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D018685:Anesthetics, Inhalation; D006993:Hypnotics and Sedatives; D008738:Methyl Ethers; D000077149:Sevoflurane; D020927:Dexmedetomidine
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