title: Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces             sarcomatoid carcinomas in mouse skin.
abstract: The Sleeping Beauty transposon system is used as a tool for insertional             mutagenesis and oncogenesis. However, little is known about the exact histological             phenotype of the tumors induced. Thus, we used immunohistochemical markers to             enable histological identification of the type of tumor induced by subcutaneous             injection of the HRAS, c-Myc and shp53 oncogenes in female C57BL/6 mice. The tumor             was removed when it reached 100 mm3 in volume. Subsequently, we used 13 immunohistochemical             markers to histologically identify the tumor type. The results suggested that             the morphology of the tumor was similar to that of sarcomatoid carcinoma.
authors: Asan Institute for Life Sciences, Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors: Sunyoung
authors: S
authors: Jung
authors: Simon Weonsang
authors: SW
authors: Ro
authors: Geunyoung
authors: G
authors: Jung
authors: Hye-Lim
authors: HL
authors: Ju
authors: Eun-Sil
authors: ES
authors: Yu
authors: Woo-Chan
authors: WC
authors: Son
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004251:DNA Transposable Elements / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007279:Injections, Subcutaneous; D051379:Mice; D008810:Mice, Inbred C57BL; D016254:Mutagenesis, Insertional / Q000235:genetics; D049268:Positron-Emission Tomography; D016271:Proto-Oncogene Proteins c-myc / Q000008:administration & dosage / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras) / Q000008:administration & dosage / Q000235:genetics*; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000235:genetics; D011859:Radiography; D019895:Transposases / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D034741:RNA, Small Interfering; D016159:Tumor Suppressor Protein p53; D019895:Transposases; C494471:sleeping beauty transposase, human; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
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