title: Intraoperative hypernatremia and polyuric syndrome induced by dexmedetomidine.
abstract: Hypernatremia and polyuria are the main symptoms of diabetes insipidus. Polyuria is characterized by a 24-h urine volume in excess of 40-50 ml/kg in adults. Dexmedetomidine, a highly selective, short-acting intravenous alpha-2 agonist, is used as a component of anesthesia, and has been suspected to induce polyuric syndrome. We report a patient who presented with severe hypernatremia and polyuria after intravenous infusion of dexmedetomidine.
authors: Department of Anesthesiology and Pain Medicine, University of California Davis Health System, Sacramento, CA 95817, USA.
authors: Fuhai
authors: F
authors: Ji
authors: Hong
authors: H
authors: Liu
mesh_terms: D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D020927:Dexmedetomidine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006955:Hypernatremia / Q000139:chemically induced*; D007262:Infusions, Intravenous / Q000379:methods; D007431:Intraoperative Complications / Q000139:chemically induced*; D011141:Polyuria / Q000139:chemically induced*; D013123:Spinal Fusion / Q000379:methods
chemical_list: D018712:Analgesics, Non-Narcotic; D020927:Dexmedetomidine
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