title: Case studies in the management of refractory bleeding in patients with haemophilia A and inhibitors.
abstract: In haemophilia patients with well-established high-titer inhibitors, even seemingly minor acute bleeding episodes or surgical procedures may become refractory to treatment and transform into limb- or life-threatening situations. In the absence of evidence-based treatment guidelines, this article presents 10 cases of difficult to control acute and surgical bleeding and offers consensus opinions regarding their management from a panel of experienced haemophilia treaters.
authors: Hemophilia and Thrombophilia Center, Rush University Medical Center, Chicago, IL 60612-3833, USA.
authors: L A
authors: LA
authors: Valentino
authors: G
authors: G
authors: Allen
authors: J C
authors: JC
authors: Gill
authors: A
authors: A
authors: Hurlet
authors: B A
authors: BA
authors: Konkle
authors: C A
authors: CA
authors: Leissinger
authors: L
authors: L
authors: Luchtman-Jones
authors: J
authors: J
authors: Powell
authors: M
authors: M
authors: Reding
authors: K
authors: K
authors: Stine
mesh_terms: D000328:Adult; D019645:Arthroplasty, Replacement, Knee; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D002675:Child, Preschool; D005169:Factor VIII / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015942:Factor VIIa / Q000627:therapeutic use; D006467:Hemophilia A / Q000601:surgery / Q000628:therapy*; D006470:Hemorrhage; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D007166:Immunosuppressive Agents; D011994:Recombinant Proteins; D005169:Factor VIII; C103587:recombinant FVIIa; D015942:Factor VIIa