title: Scedosporium prolificans pericarditis and mycotic aortic aneurysm in a lung transplant recipient receiving voriconazole prophylaxis.
abstract: Despite the adoption of antifungal prophylaxis, fungal infections remain a significant concern in lung transplant recipients. Indeed, some concern exists that such prophylaxis may increase the risk of infection with drug-resistant fungal organisms. Here, we describe a case of disseminated Scedosporium prolificans infection, presenting as pericarditis, which developed in a lung transplant patient receiving prophylactic voriconazole for 8 months. The epidemiology and clinical presentation of S. prolificans infections are reviewed, and controversies surrounding antifungal prophylaxis and the development of resistant infections are discussed.
authors: Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, California, USA. dsayah@mednet.ucla.edu
authors: D M
authors: DM
authors: Sayah
authors: B S
authors: BS
authors: Schwartz
authors: J
authors: J
authors: Kukreja
authors: J P
authors: JP
authors: Singer
authors: J A
authors: JA
authors: Golden
authors: L E
authors: LE
authors: Leard
mesh_terms: D000368:Aged; D000785:Aneurysm, Infected / Q000175:diagnosis / Q000382:microbiology* / Q000517:prevention & control; D000935:Antifungal Agents / Q000627:therapeutic use; D001014:Aortic Aneurysm / Q000175:diagnosis / Q000382:microbiology* / Q000517:prevention & control; D025141:Drug Resistance, Fungal / Q000187:drug effects; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D009181:Mycoses / Q000175:diagnosis / Q000382:microbiology* / Q000517:prevention & control; D010493:Pericarditis / Q000175:diagnosis / Q000382:microbiology* / Q000517:prevention & control; D011743:Pyrimidines / Q000627:therapeutic use*; D021681:Scedosporium / Q000302:isolation & purification*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole