title: High carbohydrate-low protein consumption maximizes Drosophila lifespan.
abstract: Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohydrates also play a central role. To clarify how nutritional factors influence longevity, nutrient consumption and lifespan were measured on a series of diets with varying yeast and sugar content. We show that optimal lifespan requires both high carbohydrate and low protein consumption, but neither nutrient by itself entirely predicts lifespan. Increased dietary carbohydrate or protein concentration does not always result in reduced feeding-the regulation of food consumption is best described by a constant daily caloric intake target. Moreover, due to differences in food intake, increased concentration of a nutrient within the diet does not necessarily result in increased consumption of that particular nutrient. Our results shed light on the issue of dietary effects on lifespan and highlight the need for accurate measures of nutrient intake in dietary manipulation studies.
authors: Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
authors: Kimberley D
authors: KD
authors: Bruce
authors: Sany
authors: S
authors: Hoxha
authors: Gil B
authors: GB
authors: Carvalho
authors: Ryuichi
authors: R
authors: Yamada
authors: Horng-Dar
authors: HD
authors: Wang
authors: Paul
authors: P
authors: Karayan
authors: Shan
authors: S
authors: He
authors: Ted
authors: T
authors: Brummel
authors: Pankaj
authors: P
authors: Kapahi
authors: William W
authors: WW
authors: Ja
mesh_terms: D000818:Animals; D018753:Diet, Protein-Restricted; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004331:Drosophila melanogaster / Q000502:physiology; D004435:Eating / Q000502:physiology; D008136:Longevity / Q000502:physiology*; D008297:Male
chemical_list: D004040:Dietary Carbohydrates
keywords: Aging; C:P; Dietary restriction; Drosophila; Feeding; Longevity; Nutrition; carbohydrate protein ratio
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