title: Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer.
abstract: Egfl7 (VE-statin) is specifically expressed by endothelial cells of normal tissues but its expression is deregulated in human cancers. Analysis of expression of Egfl7 protein and transcripts in 211 human breast cancer samples shows that Egfl7 is strongly expressed by breast tumor cells. Egfl7 expression is significantly higher in invasive ductal than in invasive lobular carcinoma. Expression of Egfl7 transcripts is also higher in lower SBR grade lesions and in lesions which are not associated with lymph node invasion. Within the invasive ductal carcinoma sub-population, expression of Egfl7 transcripts is correlated with the SBR score and with the ER+ status. High transcript and Egfl7 protein levels significantly correlate with the absence of axillary lymph node invasion. In lymph nodes, the levels of Egfl7 are correlated with the histological type of the primary lesions; they are higher in ductal than in lobular carcinoma. Egfl7 expression is thus associated with better prognosis factors and with the absence of lymph node invasion in human breast cancer lesions.
authors: CNRS UMR8161, National Center for Scientific Research, Institute of Biology of Lille, 59021 Lille, France.
authors: Géraldine
authors: G
authors: Philippin-Lauridant
authors: Marie-Christine
authors: MC
authors: Baranzelli
authors: Chantal
authors: C
authors: Samson
authors: Charles
authors: C
authors: Fournier
authors: Sébastien
authors: S
authors: Pinte
authors: Virginie
authors: V
authors: Mattot
authors: Jacques
authors: J
authors: Bonneterre
authors: Fabrice
authors: F
authors: Soncin
mesh_terms: D016475:3T3 Cells; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001365:Axilla / Q000473:pathology; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D018567:Breast Neoplasms, Male / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002135:Calcium-Binding Proteins; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D002478:Cells, Cultured; D018572:Disease-Free Survival; D066255:EGF Family of Proteins; D016228:Endothelial Growth Factors / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009928:Organ Specificity
chemical_list: D002135:Calcium-Binding Proteins; D066255:EGF Family of Proteins; C527877:EGFL7 protein, human; D016228:Endothelial Growth Factors