title: Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium fluoride on dentine hypersensitivity: a six-week randomized clinical study.
abstract: OBJECTIVE
  Evaluate the efficacy of 0.8% arginine, potassium nitrate and sodium fluoride mouthwashes on dentine hypersensitivity reduction.
  
  
  METHODS
  Six week randomized, double blinded, two cell, parallel single centre clinical study in the Dominican Republic; subjects were randomized into three treatment groups: mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride in an alcohol-free base (arginine); mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride (potassium nitrate); a control mouthwash containing 0.05% sodium fluoride (negative control). Tactile and air-blast dentine hypersensitivity assessments were conducted at baseline, thirty minutes post rinsing and two, four, and six weeks of twice-daily product use. For treatment group comparisons, ANCOVA and post hoc Tukey's pair-wise comparisons (α=0.05) were done.
  
  
  RESULTS
  Seventy-five subjects were enrolled; 69 subjects completed the study. There were no differences after thirty minutes of a single use, among the three groups with respect to mean tactile and air blast hypersensitivity scores compared to potassium nitrate and negative control mouthwashes (p<0.05). The arginine group presented a statistically significant improvement in the mean tactile scores compared to potassium nitrate and negative control groups after two, four, and six weeks (p<0.001) of product use; the arginine group showed a statistically significant enhancement in air blast hypersensitivity mean scores compared to potassium nitrate and negative control groups after two (p=0.001), four (p<0.001), and six weeks (p<0.001) of product use.
  
  
  CONCLUSIONS
  A mouthwash containing arginine provides a significant and superior reduction in dentine hypersensitivity compared to potassium nitrate and a negative control mouthwash after two weeks.
authors: University of Puerto Rico, School of Dental Medicine, San Juan, Puerto Rico. augusto.elias@upr.edu
authors: Augusto R
authors: AR
authors: Elías Boneta
authors: Rafael M
authors: RM
authors: Galán Salás
authors: Luis R
authors: LR
authors: Mateo
authors: Bernal
authors: B
authors: Stewart
authors: Sarita
authors: S
authors: Mello
authors: Lia S
authors: LS
authors: Arvanitidou
authors: Foti
authors: F
authors: Panagakos
authors: William
authors: W
authors: DeVizio
mesh_terms: D000328:Adult; D000368:Aged; D000388:Air; D000704:Analysis of Variance; D001120:Arginine / Q000737:chemistry / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000737:chemistry / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D003804:Dentin; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D011756:Diphosphates / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D008875:Middle Aged; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D010710:Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D011095:Polyethylenes / Q000627:therapeutic use*; D011446:Prospective Studies; D012969:Sodium Fluoride / Q000627:therapeutic use; D014110:Touch; D055815:Young Adult
chemical_list: D057133:Dentin Desensitizing Agents; D011756:Diphosphates; D004338:Drug Combinations; D008298:Maleates; D009067:Mouthwashes; D010710:Phosphates; D011095:Polyethylenes; C585805:pro-argin; C107241:diphosphoric acid; D012969:Sodium Fluoride; C043105:poly(methyl vinyl ether-co-maleic anhydride); D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides