title: GABBR1 has a HERV-W LTR in its regulatory region--a possible implication for schizophrenia.
abstract: Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.
authors: CEITEC-Central European Institute of Technology, Masaryk University, CZ-62500, Brno, Czech Republic. hegyihedi@gmail.com
authors: Hedi
authors: H
authors: Hegyi
mesh_terms: D020077:Endogenous Retroviruses / Q000235:genetics* / Q000378:metabolism; D015686:Gene Products, env / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D011257:Pregnancy Proteins / Q000235:genetics* / Q000378:metabolism; D040081:Protein Array Analysis; D018080:Receptors, GABA-B / Q000235:genetics* / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000821:virology*; D020079:Terminal Repeat Sequences
chemical_list: D015686:Gene Products, env; D011257:Pregnancy Proteins; D018080:Receptors, GABA-B; C405335:syncytin
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