title: The association between television watching time and all-cause mortality after breast cancer.
abstract: OBJECTIVE
  Sedentary time is a rapidly emerging independent risk factor for mortality in the general population, but its prognostic effect among cancer survivors is unknown. In a multiethnic, prospective cohort of breast cancer survivors, we hypothesized that television watching time would be independently associated with an increased risk of death from any cause.
  
  
  METHODS
  The Health, Eating, Activity, and Lifestyle Study cohort included 687 women diagnosed with local or regional breast cancer. On average 30 (±4) months postdiagnosis, women completed self-report assessments on time spent sitting watching television/videos in a typical day in the previous year. Multivariate Cox proportional hazards models were used to estimate hazard ratios (HR) and 95 % confidence intervals (CI) for death from any cause (n = 89) during the 7 years of follow-up.
  
  
  RESULTS
  Television time (top tertile vs. bottom tertile) was positively related to risk of death (HR, 1.94; 95 % CI, 1.02, 3.66, p trend = 0.024), but the association was attenuated and not statistically significant after adjustment for aerobic moderate-vigorous intensity physical activity (HR, 1.70; 95 % CI, 0.89, 3.22, p trend = 0.14) and all covariates (HR, 1.39; 95 % CI, 0.69, 2.82, p trend = 0.48).
  
  
  CONCLUSIONS
  In this first published investigation on this topic, we did not observe a statistically significant multivariate-adjusted association between television watching time and risk of death among women diagnosed with breast cancer.
  
  
  CONCLUSIONS
  These results begin an evidence base on this topic that can be built upon to inform lifestyle recommendations for this expanding, aging population.
authors: Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA. stephanie.george@nih.gov
authors: Stephanie M
authors: SM
authors: George
authors: Ashley W
authors: AW
authors: Smith
authors: Catherine M
authors: CM
authors: Alfano
authors: Heather R
authors: HR
authors: Bowles
authors: Melinda L
authors: ML
authors: Irwin
authors: Anne
authors: A
authors: McTiernan
authors: Leslie
authors: L
authors: Bernstein
authors: Kathy B
authors: KB
authors: Baumgartner
authors: Rachel
authors: R
authors: Ballard-Barbash
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000628:therapy; D002423:Cause of Death; D015897:Comorbidity; D015444:Exercise; D005260:Female; D006801:Humans; D008875:Middle Aged; D009026:Mortality; D009043:Motor Activity; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D018426:SEER Program / Q000706:statistics & numerical data; D057185:Sedentary Behavior; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D017741:Survivors / Q000706:statistics & numerical data*; D013629:Tamoxifen / Q000627:therapeutic use; D013690:Television; D013997:Time Factors
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen
references: Cancer Causes Control. 2011 Sep;22(9):1319-31
references: 21710192
references: BMC Public Health. 2012 Jan 23;12:70
references: 22269463
references: JAMA. 2005 May 25;293(20):2479-86
references: 15914748
references: Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):656-63
references: 19190157
references: Am J Epidemiol. 2010 Aug 15;172(4):419-29
references: 20650954
references: Am J Prev Med. 2011 Aug;41(2):207-15
references: 21767729
references: Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):87-95
references: 19124485
references: Med Sci Sports Exerc. 2009 May;41(5):998-1005
references: 19346988
references: Circulation. 2010 Jan 26;121(3):384-91
references: 20065160
references: Arch Intern Med. 2012 Mar 26;172(6):494-500
references: 22450936
references: J Clin Oncol. 2008 Aug 20;26(24):3958-64
references: 18711185
references: Am J Prev Med. 2011 Aug;41(2):189-96
references: 21767727
references: Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2691-709
references: 20833969
references: Med Sci Sports Exerc. 2010 May;42(5):879-85
references: 19996993
references: Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):379-86
references: 18250341
references: Arch Intern Med. 2000 Apr 10;160(7):953-8
references: 10761960
references: Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):1996-2005
references: 21980007
references: Cancer Prev Res (Phila). 2011 Apr;4(4):522-9
references: 21464032
references: Breast Cancer Res Treat. 2012 Jan;131(2):637-43
references: 21935600
references: Obes Rev. 2009 Jan;10(1):7-16
references: 18631161
references: J Am Coll Cardiol. 2011 Jan 18;57(3):292-9
references: 21232666
references: Breast Cancer Res Treat. 2011 Nov;130(1):183-94
references: 21553294
references: Med Sci Sports Exerc. 2004 Sep;36(9):1484-91
references: 15354027
references: Int J Epidemiol. 2011 Feb;40(1):150-9
references: 20576628
references: Am J Clin Nutr. 2012 Feb;95(2):437-45
references: 22218159
references: Cancer Causes Control. 2011 Apr;22(4):589-98
references: 21340493