title: Effect of the Botanical Compound LCS101 on Chemotherapy-Induced Symptoms in Patients with Breast Cancer: A Case Series Report.
abstract: The treatment of breast cancer invariably results in severe and often debilitating symptoms that can cause significant distress and severely impair daily function and quality-of-life (QOL). We treated a series of 20 female breast cancer patients with the botanical compound LCS101 as adjuvant to conventional chemotherapy. At the end of the treatment regimen, patients rated their symptoms. 70% reported that they had either no or mildly severe levels of fatigue; 60% none to mildly severe weakness; 85% none to mildly severe pain; 70% none to mildly severe nausea; and 80% none to mildly severe vomiting. Only 20% reported severe impairment of overall function, and only 40% severely impaired QOL. No toxic effects were attributed by patients to the LCS101 treatment, and 85% reported that they believed the botanical compound had helped reduce symptoms. The effects of LCS101 on clinical outcomes in breast cancer should be tested further using randomized controlled trials.
authors: Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
authors: Noah
authors: N
authors: Samuels
authors: Yair
authors: Y
authors: Maimon
authors: Rachel Y
authors: RY
authors: Zisk-Rony
keywords: botanical compounds; breast cancer; fatigue; nausea and vomiting; pain; quality-of-life
references: Curr Neuropharmacol. 2006 Apr;4(2):165-72
references: 18615126
references: J Clin Oncol. 2000 Feb;18(4):743-53
references: 10673515
references: J Altern Complement Med. 2007 Jun;13(5):555-62
references: 17604560
references: Patient Educ Couns. 2010 Oct;81(1):79-86
references: 20036097
references: J Ethnopharmacol. 2011 Jun 14;136(1):137-43
references: 21524698
references: Cancer Chemother Pharmacol. 2009 Dec;65(1):67-71
references: 19421753
references: J Pain Symptom Manage. 2006 Aug;32(2):118-28
references: 16877179
references: Ann Oncol. 1996 Feb;7(2):189-95
references: 8777177
references: Qual Life Res. 2007 Aug;16(6):947-60
references: 17457697
references: J Clin Oncol. 2005 Nov 20;23(33):8296-304
references: 16219926
references: Planta Med. 2009 Jan;75(1):41-8
references: 19031366
references: Oncologist. 2011;16(9):1197-202
references: 21712486
references: Oncol Nurs Forum. 2009 Jul;36(4):E205-14
references: 19581224
references: N Engl J Med. 2007 Jul 12;357(2):115-23
references: 17625123
references: J Womens Health (Larchmt). 2007 Nov;16(9):1348-61
references: 18001192
references: Am J Health Syst Pharm. 2007 Nov 1;64(21):2227-36
references: 17959573
references: Support Care Cancer. 2012 Aug;20(8):1901-9
references: 21994001
references: Ann Oncol. 2010 May;21 Suppl 5:v232-43
references: 20555089
references: J Ethnopharmacol. 2005 Aug 22;100(1-2):72-9
references: 16009521
references: Expert Opin Drug Metab Toxicol. 2010 Oct;6(10):1195-213
references: 20701553
references: J Clin Oncol. 2005 Apr 20;23(12):2822-30
references: 15837996
references: Clin Colorectal Cancer. 2003 Feb;2(4):253-6
references: 12620148
references: Ann Intern Med. 2001 Feb 20;134(4):330-4
references: 11182844
references: Pain. 2003 Jul;104(1-2):1-13
references: 12855309
references: N Engl J Med. 1993 Jan 28;328(4):246-52
references: 8418405
references: Cancer. 2010 Sep 15;116(18):4360-7
references: 20549827
references: Cochrane Database Syst Rev. 2009 Apr 15;(2):CD003372
references: 19370586
references: Clin Colorectal Cancer. 2011 Jun;10(2):85-96
references: 21859559
references: Expert Opin Pharmacother. 2004 Dec;5(12):2485-501
references: 15571467
references: Am J Chin Med. 2004;32(6):897-905
references: 15673195
references: Cancer. 2006 Feb 15;106(4):751-8
references: 16400678
references: Pain. 2003 Jan;101(1-2):55-64
references: 12507700