title: Neuroendocrine tumors of larynx--two case reports and literature review.
abstract: Neuroendocrine tumors (NET) of the larynx are rare and heterogenous group, with much confusion about nature and classification of these neoplasms in the past. Diagnosis is based primarily on light microscopy and confirmed by immunohistochemistry and electron microscopy. A classification in 4 different types; paraganglioma, typical carcinoid, atypical carcinoid and small cell neuroendocrine carcinoma (SCNC) is a current consensus. Thorough diagnostic and a proper classification of neuroendocrine neoplasms are of paramount importance--prognosis and treatment differ significantly. We present two cases: 63-year old patient with SCNC of the larynx and a 53-year old patient with atypical carcinoid of the larynx. OctreoScan is useful tools for diagnostics and follow up of the patients and it is predictive for effectiveness of octreotide therapy.
authors: University of Zagreb, Dubrava University Hospital, Department of ENT, Head and Neck Surgery, Zagreb, Croatia. tcaric@gmail.com
authors: Tomislav
authors: T
authors: Carić
authors: Mario
authors: M
authors: Bilić
authors: Lana Kovac
authors: LK
authors: Bilić
authors: Drago
authors: D
authors: Prgomet
authors: Jelena
authors: J
authors: Kovacić
authors: Iva Topić
authors: IT
authors: Grahovac
authors: Zdenka
authors: Z
authors: Hutinec
mesh_terms: D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D015282:Octreotide / Q000627:therapeutic use
chemical_list: D015282:Octreotide