title: Profound reduction of CD4+ lymphocytes without HIV infection: two cases from the horn of Africa.
abstract: Idiopathic CD4+ lymphocytopenia is a disorder associated with low CD4+ T cell count and opportunistic infections resembling AIDS. Most cases are described in developed countries. We report two HIV-negative patients with idiopathic CD4+ lymphocytopenia and AIDS-defining events diagnosed in Djibouti. The first patient developed lesions of Kaposi's sarcoma and the second one presented with pulmonary tuberculosis. Both patients died with severe immunodepression. In poor resource-areas where HIV testing may not be available it is important to bear in mind that severe immunodepression and a clinical presentation compatible with AIDS do not necessary carry the diagnosis of AIDS.
authors: Catalan Association for the Control of Tuberculosis in the Third World (ACTMON), Barcelona, Spain. olleuganda@gmail.com
authors: J E
authors: JE
authors: Ollé-Goig
authors: J
authors: J
authors: Ramírez
authors: C
authors: C
authors: Cervera
authors: J M
authors: JM
authors: Miró
mesh_terms: D000328:Adult; D001706:Biopsy; D018791:CD4 Lymphocyte Count; D015730:Djibouti; D017809:Fatal Outcome; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications*; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications*; D014397:Tuberculosis, Pulmonary / Q000150:complications*
keywords: Acquired immunodeficiency syndrome; Djibouti; Human immunodeficiency virus; Kaposi's sarcoma; Lymphopenia; tuberculosis
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