title: Potent in vitro antibacterial activity of DS-8587, a novel broad-spectrum quinolone, against Acinetobacter baumannii.
abstract: We investigated the in vitro activity of DS-8587, a novel fluoroquinolone, against Acinetobacter baumannii. The MICs of DS-8587 against clinical isolates and its inhibitory activity against target enzymes were superior to those of ciprofloxacin and levofloxacin. Furthermore, the antibacterial activity of DS-8587 was less affected by adeA/adeB/adeC or abeM efflux pumps than was that of ciprofloxacin and the frequency of single-step mutations with DS-8587 was lower than that with ciprofloxacin. DS-8587 might be an effective agent against A. baumannii infection.
authors: Biological Research Laboratories, Daiichi Sankyo, Co, Ltd, Tokyo, Japan. higuchi.saito.ir@daiichisankyo.co.jp
authors: Saito
authors: S
authors: Higuchi
authors: Yoshikuni
authors: Y
authors: Onodera
authors: Megumi
authors: M
authors: Chiba
authors: Kazuki
authors: K
authors: Hoshino
authors: Naomasa
authors: N
authors: Gotoh
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002939:Ciprofloxacin / Q000494:pharmacology; D024841:Fluoroquinolones / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics; D015363:Quinolones / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C000594795:DS-8587; D024841:Fluoroquinolones; D015363:Quinolones; D002939:Ciprofloxacin
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