title: Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys.
abstract: Prepubertal testosterone levels are lower in intellectually gifted boys. The aim of this pilot study was to analyze potential genetic factors related to testosterone metabolism in control and gifted boys. Intellectually gifted (IQ>130; n = 95) and control (n = 67) boys were genotyped. Polymorphisms of interests were chosen in genes including androgen and estrogen receptors, 5-alpha reductase, aromatase and sex hormone binding globulin. Significant differences between control and gifted boys in genotype distributions were found for ESR2 (rs928554) and SHBG (rs1799941). A significantly lower number of CAG repeats in the AR gene were found in gifted boys. Our results support the role of genetic factors related to testosterone metabolism in intellectual giftedness. Increased androgen signaling might explain previous results of lower testosterone levels in intellectually gifted boys and add to the understanding of variability in cognitive abilities.
authors: Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovak Republic. petercelec@gmail.com
authors: Peter
authors: P
authors: Celec
authors: Denisa
authors: D
authors: Tretinárová
authors: Gabriel
authors: G
authors: Minárik
authors: Andrej
authors: A
authors: Ficek
authors: Tomáš
authors: T
authors: Szemes
authors: Silvia
authors: S
authors: Lakatošová
authors: Eva
authors: E
authors: Schmidtová
authors: Ján
authors: J
authors: Turňa
authors: Ľudevít
authors: Ľ
authors: Kádaši
authors: Daniela
authors: D
authors: Ostatníková
mesh_terms: D000293:Adolescent; D000483:Alleles; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D011944:Receptors, Androgen / Q000235:genetics; D013739:Testosterone / Q000378:metabolism*
chemical_list: D011944:Receptors, Androgen; D013739:Testosterone
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