title: The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study.
abstract: OBJECTIVE
  To investigate the independent and combined associations between female and male body mass index (BMI) on the probability of achieving a live birth after treatments with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) under adjustment for relevant covariates.
  
  
  METHODS
  Population-based cohort study.
  
  
  METHODS
  Danish national registers.
  
  
  METHODS
  Patients with permanent residence in Denmark receiving IVF or ICSI treatment with use of autologous oocytes from January 1, 2006, to September 30, 2010.
  
  
  METHODS
  None.
  
  
  METHODS
  Live birth. Analyses were adjusted for age and smoking at treatment initiation and results stratified by BMI groups and presented by IVF/ICSI treatment.
  
  
  RESULTS
  In total, 12,566 women and their partners went through 25,191 IVF/ICSI cycles with 23.7% ending in a live birth. Overweight and obese women with regular ovulation had reduced odds of live birth (adjusted OR 0.88, 95% CI 0.79-0.99 and adjusted OR 0.75, 95% CI 0.63-0.90, respectively) compared with normal-weight women. IVF-treated couples with both partners having BMI ≥25 kg/m(2) had the lowest odds of live birth (adjusted OR 0.73, 95% CI 0.48-1.11) compared with couples with BMI <25 kg/m(2). BMI showed no significant effect on chance of live birth after ICSI.
  
  
  CONCLUSIONS
  Increased female and male BMI, both independently and combined, negatively influenced live birth after IVF treatments. With ICSI, the association with BMI was less clear.
authors: Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. gilp@sund.ku.dk
authors: Gitte Lindved
authors: GL
authors: Petersen
authors: Lone
authors: L
authors: Schmidt
authors: Anja
authors: A
authors: Pinborg
authors: Mads
authors: M
authors: Kamper-Jørgensen
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D050498:Live Birth / Q000453:epidemiology*; D008297:Male; D050177:Overweight / Q000453:epidemiology* / Q000503:physiopathology; D011159:Population Surveillance / Q000379:methods; D011247:Pregnancy; D012042:Registries; D027724:Reproductive Techniques, Assisted / Q000639:trends*; D016896:Treatment Outcome