title: A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: fabrication, characterization and properties for controlled release of salidroside.
abstract: A novel pH-responsive nano-carrier MSNs-PAA, possessing mesoporous silica nanoparticles (MSNs) cores and poly(acrylic acid) (PAA) shell-layers, was developed for controlled release of salidroside. The vinyl double bonds modified MSNs were synthesized by using cetyltrimethylammonium bromide (CTAB) as templates, tetraethyl orthosilicate (TEOS) as silicon source, and 3-(trimethoxylsilyl) propyl methacrylate (MPS) as surface modification functionalities. The pH-responsive layers of PAA were grafted onto the vinyl double bonds of the MSNs via precipitation polymerization, producing the MSNs-PAA with a hollow cubic core and mesoporous shell with penetrating pore channels. The characteristic results also showed that PAA was successfully grafted onto the surface of the MSNs. The MSNs-PAA was investigated as carriers for loading and regulating the release of salidroside in different pH solutions for the first time. The results demonstrated that the PAA layers on the surface of MSNs-PAA exhibited opened and closed states at different pH values, and thus could regulate the uptake and release of salidroside. The application of such pH-responsive nano-carrier might offer a potential platform for controlled delivery and increasing the bioavailability of drugs.
authors: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors: Hailong
authors: H
authors: Peng
authors: Ruichen
authors: R
authors: Dong
authors: Shenqi
authors: S
authors: Wang
authors: Zhong
authors: Z
authors: Zhang
authors: Mei
authors: M
authors: Luo
authors: Chunqing
authors: C
authors: Bai
authors: Qiang
authors: Q
authors: Zhao
authors: Jinhua
authors: J
authors: Li
authors: Lingxin
authors: L
authors: Chen
authors: Hua
authors: H
authors: Xiong
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D005960:Glucosides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D002593:Cetrimonium Compounds; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005960:Glucosides; D010636:Phenols; C006903:carbopol 940; D012822:Silicon Dioxide; C009172:rhodioloside; D000077286:Cetrimonium