title: Association between polymorphisms in interleukin-4Rα and interleukin-13 and glioma risk: a meta-analysis.
abstract: BACKGROUND
  It has been suggested that allergies are inversely associated with glioma risk. Single nucleotide polymorphisms in two allergy-related genes [interleukin (IL)-4Rα, IL-13] have been implicated in susceptibility to glioma; however, results from the published studies remained inconclusive.
  
  
  METHODS
  To derive a more precise relationship, we conducted a meta-analysis including seven case-control studies that investigated the influence of IL-4Rα rs1801275 and IL13 rs20541 polymorphisms on glioma risk. Data were extracted from these studies and pooled odds ratios (OR) with 95% confidence intervals (CI) were used to investigate the strength of the association.
  
  
  RESULTS
  Overall, the pooled analysis showed that there was no significant association between the IL-4Rα rs1801275 polymorphism and glioma risk (OR = 0.99, 95%CI: 0.79-1.25, AG/GG vs. AA). However, we found that the IL13 rs20541 variant genotypes (GA/AA) were significantly associated with reduced risk for glioma (OR = 0.85, 95%CI: 0.75-0.97, GA/AA vs. GG). In the stratified analyses by ethnicity, marginally significant association between the IL13 rs20541 polymorphism and decreased glioma risk was found among Asian populations in dominant models (OR = 0.84, 95%CI: 0.70-1.00, GA/AA vs. GG).
  
  
  CONCLUSIONS
  This meta-analysis suggests that the IL13 rs20541 but not the IL-4Rα rs1801275 polymorphism may be a genetic predictor for glioma. More studies with larger sample size are warranted to further elucidate the impact of the IL13 rs20541 polymorphism on glioma risk.
authors: Department of Neurosurgery, The First People's Hospital of Yancheng affiliated with Nantong University, Yancheng 224001, PR China. yc_sunguan@163.com
authors: Guan
authors: G
authors: Sun
authors: Xiefeng
authors: X
authors: Wang
authors: Lei
authors: L
authors: Shi
authors: Xiao
authors: X
authors: Yue
authors: Linshan
authors: L
authors: Fu
authors: Chen
authors: C
authors: Chen
authors: Zhengyi
authors: Z
authors: Li
authors: Tianhong
authors: T
authors: Pan
authors: Zhengqiang
authors: Z
authors: Wan
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005910:Glioma / Q000235:genetics*; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D018793:Interleukin-13; D053662:Interleukin-4 Receptor alpha Subunit