title: Controversies in the use & implementation of drug-eluting stent technology.
abstract: The introduction of drug eluting stents has resulted in dramatic reductions in the rates of restenosis and the need for repeat revascularization. In the last several years, concern has been raised regarding the long-term safety of this technology, particularly in the area of late restenosis and stent thrombosis. The development of newer anti-restenotic drug coatings, biodegradable polymers and even completely bioabsorbable stents offer the potential to address these limitations. Additional questions that have recently come to the forefront include the optimal duration of dual antiplatelet therapy, the use of platelet reactivity assays and genetic testing and drug eluting stent use in the treatment of acute myocardial infarction. This article will attempt to address these and other areas of controversy in the use and implementation of drug eluting stents.
authors: Regional Cardiac Cath Lab & Department of Cardiology, Kaiser Permanente, Los Angeles, CA, USA.
authors: Brandon K
authors: BK
authors: Itagaki
authors: Somjot S
authors: SS
authors: Brar
mesh_terms: D020341:Absorbable Implants; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D001241:Aspirin / Q000627:therapeutic use; D000077144:Clopidogrel; D020099:Coated Materials, Biocompatible; D023903:Coronary Restenosis / Q000188:drug therapy / Q000628:therapy*; D065731:Cytochrome P-450 CYP2C19; D004351:Drug Resistance / Q000235:genetics; D054855:Drug-Eluting Stents / Q000009:adverse effects / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy / Q000628:therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011110:Polymorphism, Genetic / Q000235:genetics; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D020099:Coated Materials, Biocompatible; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D013988:Ticlopidine; D001241:Aspirin
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