title: Genetic modeling of ovarian phenotypes in mice for the study of human polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) presents with a range of clinical complications including hyperandrogenism, polycystic ovaries, chronic oligo/anovulation, infertility, and metabolic alterations related to insulin resistance. Because the mechanism by which this disorder develops is poorly understood, information from experimental models of human disease phenotypes may help to define the mechanisms for the initiation and development of PCOS-related pathological events. The establishment of animal models compatible with human PCOS is challenging, and applying the lessons learned from these models to human PCOS is often complicated. In this mini-review we provide examples of currently available genetic mouse models, their ovarian phenotypes, and their possible relationship to different aspects of human PCOS. Because of the practical and ethical limitations of studying PCOS-related events in humans, our understanding of the mechanisms that contribute to the etiology of human PCOS may be enhanced through further study of these transgenic and knockout mouse models.
authors: Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg Gothenburg, Sweden ; Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College; Institute of Acupuncture Research (WHO Collaborating Center for Traditional Medicine); Institutes of Brain Science, Fudan University Shanghai, China.
authors: Yi
authors: Y
authors: Feng
authors: Xin
authors: X
authors: Li
authors: Ruijin
authors: R
authors: Shao
keywords: PCOS; hemorrhagic cystic follicles; transgenic and knockout mice
references: Fertil Steril. 2002 Dec;78(6):1301-8
references: 12477528
references: Fertil Steril. 2009 Feb;91(2):456-88
references: 18950759
references: Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12729-34
references: 11070086
references: Recent Prog Horm Res. 1998;53:217-56
references: 9769710
references: Endocrinology. 2009 Jun;150(6):2906-14
references: 19264868
references: Clin Endocrinol (Oxf). 1996 Nov;45(5):623-9
references: 8977761
references: Endocrinology. 2000 Mar;141(3):1073-82
references: 10698183
references: Endocrinology. 1997 Aug;138(8):3540-7
references: 9231809
references: J Biol Chem. 2003 Jul 18;278(29):26380-90
references: 12734205
references: Endocrinology. 1999 Jun;140(6):2733-44
references: 10342864
references: Endocrinology. 2002 Oct;143(10):4084-95
references: 12239120
references: Lancet. 2007 Aug 25;370(9588):685-97
references: 17720020
references: Endocr J. 2004 Oct;51(5):467-72
references: 15516780
references: Endocrinology. 1978 Aug;103(2):501-12
references: 744098
references: J Clin Endocrinol Metab. 2004 Sep;89(9):4343-50
references: 15356031
references: Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11673-7
references: 8265607
references: Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11162-6
references: 8248223
references: Biol Reprod. 2003 Jul;69(1):338-46
references: 12672665
references: Endocrinology. 2000 Jul;141(7):2614-23
references: 10875266
references: Annu Rev Physiol. 1997;59:349-63
references: 9074768
references: Endocrinology. 2009 Aug;150(8):3855-62
references: 19423761
references: Endocrinology. 1981 Mar;108(3):962-9
references: 6257501
references: Mol Endocrinol. 1999 Jun;13(6):851-65
references: 10379885
references: Hum Reprod Update. 2008 Jul-Aug;14(4):367-78
references: 18499708
references: J Endocrinol Invest. 1998 Oct;21(9):602-11
references: 9856414
references: Anat Rec. 1991 Oct;231(2):185-92
references: 1836118
references: Biol Reprod. 1986 Oct;35(3):647-55
references: 3098314
references: Endocrinology. 2007 Aug;148(8):3781-91
references: 17495003
references: Biol Reprod. 1978 Dec;19(5):1036-9
references: 743539
references: Endocrinology. 2000 Mar;141(3):1059-72
references: 10698182
references: Annu Rev Med. 2001;52:401-19
references: 11160786
references: Mol Hum Reprod. 2009 Jan;15(1):19-26
references: 19066200
references: Hum Reprod. 2010 Feb;25(2):544-51
references: 19910321
references: J Clin Endocrinol Metab. 2001 Mar;86(3):1318-23
references: 11238527
references: J Mol Endocrinol. 2005 Apr;34(2):489-503
references: 15821112
references: N Engl J Med. 2005 Mar 24;352(12):1223-36
references: 15788499
references: Nat Genet. 1997 Feb;15(2):201-4
references: 9020850
references: Mol Endocrinol. 2004 Dec;18(12):3050-63
references: 15308691
references: Reprod Biomed Online. 2004 Nov;9(5):505-10
references: 15588467
references: Fertil Steril. 1998 Feb;69(2):236-41
references: 9496335
references: J Mol Endocrinol. 2007 Jul;39(1):9-16
references: 17601881
references: Endocrinology. 1979 May;104(5):1411-7
references: 220034
references: Endocrinology. 1999 Dec;140(12):5855-65
references: 10579351
references: Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1322-6
references: 7877975
references: Development. 2000 Oct;127(19):4277-91
references: 10976058