title: Intrinsic feedbacks in MAPK signaling cascades lead to bistability and oscillations.
abstract: Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be quantitatively and, more importantly, qualitatively modified when this cycle is coupled to a signaling pathway as opposed to being isolated. This property was named retroactivity. These two results are studied together in this paper showing the existence of interesting phenomena--oscillations and bistability--in signaling cascades possessing at least one stage with a double-phosphorylation cycle as in MAPK cascades.
authors: Institut Non Linéaire de Nice, UMR 7335 CNRS, University of Nice Sophia Antipolis, 1361 route des Lucioles, 06560 Valbonne, France. jacques-alexandre.sepulchre@inln.cnrs.fr
authors: Jacques-Alexandre
authors: JA
authors: Sepulchre
authors: Alejandra C
authors: AC
authors: Ventura
mesh_terms: D004795:Enzyme Stability; D020935:MAP Kinase Signaling System; D008962:Models, Theoretical; D010766:Phosphorylation