title: Portomesenteric vein thrombosis in patients with inflammatory bowel disease.
abstract: BACKGROUND
  Inflammatory bowel disease (IBD) is associated with a high risk of deep venous thromboembolism. However, few data are available so far on portomesenteric vein thrombosis (PMVT). The aim of this study was to describe the characteristics of PMVT in patients with IBD.
  
  
  METHODS
  A retrospective study was conducted at 13 GETAID (Groupe d'Etude Thérapeutique des Affections Inflammatoires du Tube Digestif) centers from January 1995 to June 2010. The following data were collected, using a standardized questionnaire: characteristics of IBD, disease status at the time of PMVT, PMVT characteristics and mode of discovery, concomitant prothrombotic disorders, anticoagulant therapy, and evolution of PMVT.
  
  
  RESULTS
  Fifty cases (29 men and 21 women; median age, 41 years) were identified, including 14 patients with ulcerative colitis and 36 with Crohn's disease. Thirty-one patients (62%) presented with acute PMVT. Twenty-four patients had previously undergone surgical treatment, and IBD was active in 23 cases (77%) of acute thrombosis. The discovery of PMVT was fortuitous in 40% of our cases. Among the 43 patients screened for a prothrombotic disorder, abnormalities were observed in 17 patients (40%) (mainly hyperhomocysteinemia, n = 12). Forty-four patients (88%) were treated with anticoagulants. Recanalization of the vein was significantly more successful in patients with acute thrombosis (65% versus 37%, P = 0.05).
  
  
  CONCLUSIONS
  PMVT can occur when IBD is inactive, and its diagnosis was fortuitous in 40% of our cases. Screening for prothrombotic disorders is essential because it is positive in more than one third of cases.
authors: Department of Hepato-Gastroenterology, Centre Hospitalier Intercommunal Le Raincy-Montfermeil, Montfermeil, France.
authors: Cécilia
authors: C
authors: Landman
authors: Stéphane
authors: S
authors: Nahon
authors: Jacques
authors: J
authors: Cosnes
authors: Yoram
authors: Y
authors: Bouhnik
authors: Hedia
authors: H
authors: Brixi-Benmansour
authors: Guillaume
authors: G
authors: Bouguen
authors: Jean-Frédéric
authors: JF
authors: Colombel
authors: Guillaume
authors: G
authors: Savoye
authors: Benoit
authors: B
authors: Coffin
authors: Vered
authors: V
authors: Abitbol
authors: Jerôme
authors: J
authors: Filippi
authors: David
authors: D
authors: Laharie
authors: Jacques
authors: J
authors: Moreau
authors: Michel
authors: M
authors: Veyrac
authors: Matthieu
authors: M
authors: Allez
authors: Philippe
authors: P
authors: Marteau
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008642:Mesenteric Veins; D008875:Middle Aged; D011169:Portal Vein; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000925:Anticoagulants