title: Stroke in the eye of the beholder.
abstract: The pathophysiological changes that occur during ischemic stroke can have a profound effect on the surrounding nerve tissue. To this end, we advance the hypothesis that retinal damage can occur as a consequence of ischemic stroke in animal models. We discuss the preclinical evidence over the last 3 decades supporting this hypothesis of retinal damage following ischemic stroke. In our evaluation of the hypothesis, we highlight the animal models providing evidence of pathological and mechanistic link between ischemic stroke and retinal damage. That retinal damage is closely associated with ischemic stroke, yet remains neglected in stroke treatment regimen, provides the impetus for recognizing the treatment of retinal damage as a critical component of stroke therapy.
authors: Department of Neurosurgery and Brain Repair, 12901 Bruce B. Downs Blvd, University of South Florida, Tampa, FL 33612, USA.
authors: Hiroto
authors: H
authors: Ishikawa
authors: Mathew
authors: M
authors: Caputo
authors: Nicholas
authors: N
authors: Franzese
authors: Nathan L
authors: NL
authors: Weinbren
authors: Adam
authors: A
authors: Slakter
authors: Milan
authors: M
authors: Patel
authors: Christine E
authors: CE
authors: Stahl
authors: Maria Alejandra
authors: MA
authors: Jacotte
authors: Sandra
authors: S
authors: Acosta
authors: Giorgio
authors: G
authors: Franyuti
authors: Kazutaka
authors: K
authors: Shinozuka
authors: Naoki
authors: N
authors: Tajiri
authors: Harry
authors: H
authors: van Loveren
authors: Yuji
authors: Y
authors: Kaneko
authors: Cesar V
authors: CV
authors: Borlongan
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D012164:Retinal Diseases / Q000209:etiology* / Q000503:physiopathology*; D012171:Retinal Vessels / Q000503:physiopathology*; D020521:Stroke / Q000150:complications* / Q000503:physiopathology*
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