title: Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a negative control mouthwash on dentin hypersensitivity reduction. A randomized clinical trial.
abstract: OBJECTIVE
  The objective of this eight week, single-center, two-cell, double-blind, and randomized clinical study was to evaluate the dentin hypersensitivity reduction efficacy of a mouthwash using Pro-Argin™ Mouthwash Technology containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride in an alcohol-free base ("Arginine Mouthwash") compared to an ordinary mouthwash without any active ingredients ("Negative Control").
  
  
  METHODS
  Qualifying subjects who presented two hypersensitive teeth with a tactile hypersensitivity score between 10 and 50 g of force, and an air blast hypersensitivity score of 2 or 3 participated in this study and were randomized into one of two treatment groups. Subjects brushed with the toothbrush and fluoride toothpaste provided and then rinsed with 20 mL of their assigned mouthwash for 30s twice daily. Subjects refrained from eating or drinking for 30 min after rinsing. Dentin hypersensitivity assessments, as well as examinations of oral hard and soft tissues, were conducted at the baseline visit and again after two weeks, four weeks and eight weeks of product use.
  
  
  RESULTS
  Ninety (90) subjects entered and completed the eight week study. After two weeks, four weeks and eight weeks of product use, subjects in the Arginine Mouthwash group exhibited statistically significant (p<0.05) improvements in mean tactile and air blast hypersensitivity scores as compared to the Negative Control Mouthwash.
  
  
  CONCLUSIONS
  The results of this study support the conclusion that the Arginine Mouthwash provides a significant reduction in dentin hypersensitivity after eight weeks of product use as compared to a Negative Control mouthwash.
authors: Department of Preventive Dentistry, College of Stomatology, West China University of Medial Sciences, Chengdu, China. hudeyu@vip.sina.com
authors: Deyu
authors: D
authors: Hu
authors: Bernal
authors: B
authors: Stewart
authors: Sarita
authors: S
authors: Mello
authors: Lia
authors: L
authors: Arvanitidou
authors: Foti
authors: F
authors: Panagakos
authors: William
authors: W
authors: De Vizio
authors: Yun Po
authors: YP
authors: Zhang
authors: Luis R
authors: LR
authors: Mateo
authors: Wei
authors: W
authors: Yin
mesh_terms: D000328:Adult; D000368:Aged; D001120:Arginine / Q000737:chemistry / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000737:chemistry / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D011756:Diphosphates / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D008875:Middle Aged; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D010710:Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D011095:Polyethylenes / Q000627:therapeutic use*; D011446:Prospective Studies; D012969:Sodium Fluoride / Q000627:therapeutic use; D014110:Touch; D055815:Young Adult
chemical_list: D057133:Dentin Desensitizing Agents; D011756:Diphosphates; D004338:Drug Combinations; D008298:Maleates; D009067:Mouthwashes; D010710:Phosphates; D011095:Polyethylenes; C585805:pro-argin; C107241:diphosphoric acid; D012969:Sodium Fluoride; C043105:poly(methyl vinyl ether-co-maleic anhydride); D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides