title: Serum biomarkers identification by mass spectrometry in high-mortality tumors.
abstract: Cancer affects millions of people worldwide. Tumor mortality is substantially due to diagnosis at stages that are too late for therapies to be effective. Advances in screening methods have improved the early diagnosis, prognosis, and survival for some cancers. Several validated biomarkers are currently used to diagnose and monitor the progression of cancer, but none of them shows adequate specificity, sensitivity, and predictive value for population screening. So, there is an urgent need to isolate novel sensitive, specific biomarkers to detect the disease early and improve prognosis, especially in high-mortality tumors. Proteomic techniques are powerful tools to help in diagnosis and monitoring of treatment and progression of the disease. During the last decade, mass spectrometry has assumed a key role in most of the proteomic analyses that are focused on identifying cancer biomarkers in human serum, making it possible to identify and characterize at the molecular level many proteins or peptides differentially expressed. In this paper we summarize the results of mass spectrometry serum profiling and biomarker identification in high mortality tumors, such as ovarian, liver, lung, and pancreatic cancer.
authors: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio Coppito 2, 67100 L'Aquila, Italy.
authors: Alessandra
authors: A
authors: Tessitore
authors: Agata
authors: A
authors: Gaggiano
authors: Germana
authors: G
authors: Cicciarelli
authors: Daniela
authors: D
authors: Verzella
authors: Daria
authors: D
authors: Capece
authors: Mariafausta
authors: M
authors: Fischietti
authors: Francesca
authors: F
authors: Zazzeroni
authors: Edoardo
authors: E
authors: Alesse
references: World J Gastroenterol. 2006 Dec 21;12(47):7604-12
references: 17171788
references: J Clin Invest. 2006 Jan;116(1):26-30
references: 16395400
references: Anal Chem. 1991 Dec 15;63(24):1193A-1203A
references: 1789447
references: Proteomics. 2005 Jan;5(1):307-17
references: 15619298
references: Cancer Res. 2004 Aug 15;64(16):5882-90
references: 15313933
references: BMC Genomics. 2006 Oct 30;7:278
references: 17074082
references: Proteomics. 2003 Sep;3(9):1720-4
references: 12973732
references: Proteomics. 2005 Sep;5(14):3790-7
references: 16121334
references: Annu Rev Biophys Biomol Struct. 2004;33:297-316
references: 15139815
references: Proteomics. 2006 May;6(9):2895-902
references: 16586431
references: PLoS One. 2012;7(5):e37797
references: 22629457
references: Biol Chem. 2008 Sep;389(9):1225-33
references: 18713009
references: PLoS One. 2009;4(3):e4763
references: 19274087
references: Mol Cell Proteomics. 2002 Nov;1(11):845-67
references: 12488461
references: J Cancer Res Clin Oncol. 2010 Aug;136(8):1151-9
references: 20130913
references: J Proteome Res. 2011 May 6;10(5):2359-76
references: 21443201
references: Sci China C Life Sci. 2007 Jun;50(3):305-11
references: 17609886
references: J Thorac Oncol. 2007 Oct;2(10):893-901
references: 17909350
references: Biotechniques. 2008 Apr;44(5):667-8, 670
references: 18474043
references: Nat Biotechnol. 2003 Jun;21(6):660-6
references: 12754519
references: Dis Markers. 2010;29(1):11-20
references: 20826913
references: J Biomed Biotechnol. 2010;2010:906082
references: 20029632
references: Oncol Lett. 2011 Jul;2(4):693-699
references: 22848251
references: Mol Cell Proteomics. 2004 Apr;3(4):367-78
references: 14990683
references: Hepatology. 2005 Jan;41(1):40-7
references: 15690480
references: Nat Protoc. 2007;2(2):334-9
references: 17406594
references: Methods Mol Biol. 2012;823:237-49
references: 22081349
references: Cancer. 2012 Jan 15;118(2):571-8
references: 21713765
references: Am J Pathol. 2003 Mar;162(3):963-75
references: 12598329
references: Br J Surg. 1996 May;83(5):625-31
references: 8689203
references: Cancer Res. 2012 Mar 15;72(6):1467-77
references: 22282660
references: BMC Cancer. 2005 Jul 20;5:83
references: 16029516
references: Pancreatology. 2009;9(1-2):127-35
references: 19077463
references: J Proteomics. 2011 Nov 18;74(12):2856-65
references: 21787892
references: Hepatology. 2002 Nov;36(5 Suppl 1):S84-92
references: 12407580
references: Clin Cancer Res. 2003 Aug 1;9(8):2904-11
references: 12912935
references: J Proteome Res. 2011 Mar 4;10(3):1383-95
references: 21141971
references: Nature. 2003 Mar 13;422(6928):198-207
references: 12634793
references: Curr Opin Gastroenterol. 2006 May;22(3):248-53
references: 16550039
references: Br J Cancer. 2010 Jul 27;103(3):391-400
references: 20588270
references: J Proteome Res. 2010 Dec 3;9(12):6440-9
references: 20931982
references: Cancer Genomics Proteomics. 2011 Nov-Dec;8(6):289-305
references: 22086897
references: Expert Rev Proteomics. 2008 Dec;5(6):841-64
references: 19086863
references: Biochim Biophys Acta. 2010 Mar;1804(3):493-8
references: 19766740
references: Int J Biol Markers. 2011 Oct-Dec;26(4):262-73
references: 21928244
references: Cancer Sci. 2007 Oct;98(10):1617-24
references: 17683510
references: Clin Lung Cancer. 2011 May;12(3):172-9
references: 21663860
references: Diagn Pathol. 2010 Sep 20;5:60
references: 20854674
references: Clin Chem. 2002 Oct;48(10):1835-43
references: 12324514
references: Oncol Rep. 2010 Nov;24(5):1271-6
references: 20878120
references: Hosp Pract (1995). 2011 Oct;39(4):107-12
references: 22056830
references: Hepatology. 2007 Apr;45(4):948-56
references: 17393466
references: Eur J Obstet Gynecol Reprod Biol. 2012 Aug;163(2):216-8
references: 22633170
references: Mass Spectrom Rev. 2004 Jan-Feb;23(1):34-44
references: 14625891
references: PLoS One. 2011 Apr 12;6(4):e18567
references: 21533267
references: Clin Chem. 2007 Nov;53(11):1915-20
references: 17890439
references: Gynecol Oncol. 2001 Jul;82(1):40-8
references: 11426960
references: Int J Oncol. 2005 Nov;27(5):1361-9
references: 16211233
references: J Proteome Res. 2006 Jul;5(7):1626-35
references: 16823970
references: J Proteome Res. 2010 Jan;9(1):104-12
references: 19764807
references: Mol Cell Proteomics. 2004 Apr;3(4):311-26
references: 14718574
references: Dis Markers. 2003-2004;19(4-5):239-49
references: 15266667
references: Clin Chem. 2007 Jun;53(6):1067-74
references: 17463175
references: Science. 1989 Oct 6;246(4926):64-71
references: 2675315
references: Proteomics. 2005 Nov;5(17):4581-8
references: 16240287
references: Proteomics. 2005 Nov;5(17):4589-96
references: 16237736
references: Cancer Invest. 2012 Feb;30(2):189-97
references: 22149058
references: World J Gastroenterol. 2005 Dec 21;11(47):7391-400
references: 16437707
references: Clin Cancer Res. 2009 Mar 1;15(5):1808-13
references: 19223512
references: Pancreas. 2008 Jan;36(1):61-9
references: 18192883
references: Oncol Rep. 2010 Jul;24(1):263-70
references: 20514471
references: J Am Chem Soc. 2011 Nov 30;133(47):19178-88
references: 21999289
references: Ann Surg. 1999 May;229(5):613-22; discussion 622-4
references: 10235519
references: Cancer Res. 2006 Mar 1;66(5):2592-9
references: 16510577
references: Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12343-8
references: 14523236
references: BMC Gastroenterol. 2010 Jun 29;10:68
references: 20587030
references: Curr Opin Pulm Med. 2010 Jul;16(4):301-6
references: 20508525
references: Pancreas. 2007 Mar;34(2):205-14
references: 17312459
references: Anticancer Res. 2008 Sep-Oct;28(5B):3027-33
references: 19031951
references: Am J Obstet Gynecol. 2008 Sep;199(3):215-23
references: 18468571
references: Cell Stress Chaperones. 2013 Mar;18(2):235-41
references: 23073653
references: Proteomics. 2005 Oct;5(15):4034-45
references: 16152657
references: Biochem J. 1980 Jul 1;189(1):27-34
references: 7458904
references: Chest. 2011 Jan;139(1):183-9
references: 21208878
references: CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300
references: 20610543
references: Nat Rev Cancer. 2006 Dec;6(12):961-7
references: 17093504
references: Breast Cancer Res Treat. 2010 Feb;119(3):551-8
references: 19214742
references: Clin Chem Lab Med. 2009;47(6):713-23
references: 19426140
references: Biomarkers. 2011 Feb;16(1):20-30
references: 20964562
references: Lancet. 2002 Feb 16;359(9306):572-7
references: 11867112
references: Ann Surg Oncol. 2010 Sep;17(9):2518-25
references: 20354800
references: Mol Cell Proteomics. 2007 Jan;6(1):141-9
references: 17074749
references: J Thorac Oncol. 2011 Apr;6(4):725-34
references: 21304412
references: J Invest Surg. 2012 Feb;25(1):37-42
references: 22272636
references: Clin Cancer Res. 2008 Jan 15;14(2):470-7
references: 18223221
references: Nat Biotechnol. 2003 Jun;21(6):667-72
references: 12754521
references: N Engl J Med. 2004 Dec 9;351(24):2519-29
references: 15590954
references: Cancer Sci. 2009 Dec;100(12):2292-301
references: 19775290
references: Proteome Sci. 2008 Mar 10;6:10
references: 18331625
references: J Gastrointest Surg. 2005 Sep-Oct;9(7):922-7
references: 16137585
references: Ann Surg Oncol. 2010 May;17(5):1406-13
references: 20094918
references: Clin Cancer Res. 2009 Jun 1;15(11):3812-9
references: 19470732
references: Biotechnol Genet Eng Rev. 2003;20:199-244
references: 14997853
references: J Proteome Res. 2010 Feb 5;9(2):798-805
references: 19961239
references: Cancer Sci. 2005 Mar;96(3):197-201
references: 15771624
references: Nano Lett. 2008 Jan;8(1):350-61
references: 18076201
references: J Proteome Res. 2005 Jul-Aug;4(4):1073-85
references: 16083256
references: N Engl J Med. 2008 Sep 25;359(13):1367-80
references: 18815398
references: Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):160-71
references: 21148121
references: Br J Cancer. 2004 Jul 5;91(1):129-40
references: 15199385
references: Br J Cancer. 2010 Jun 8;102(12):1731-5
references: 20502455
references: Clin Chem. 2009 Jun;55(6):1108-17
references: 19372185
references: J Clin Lab Anal. 2008;22(2):131-7
references: 18348318
references: Int J Gynecol Cancer. 2008 May-Jun;18(3):470-5
references: 17655680
references: Cancer Lett. 2009 Jul 8;279(2):163-70
references: 19268439
references: Proc Natl Acad Sci U S A. 1986 Sep;83(17):6233-7
references: 3462691
references: J Gastroenterol Hepatol. 2009 Jan;24(1):55-62
references: 18823443
references: J Cancer Res Clin Oncol. 2007 Nov;133(11):825-34
references: 17516088
references: J Mater Chem. 2009 Aug 7;19(29):5071-5077
references: 20585471
references: Oncol Rep. 2011 Jul;26(1):287-92
references: 21519797
references: Methods Mol Biol. 2012;818:11-33
references: 22083813
references: J Chromatogr A. 2005 May 6;1073(1-2):25-33
references: 15909502
references: Curr Opin Obstet Gynecol. 2000 Feb;12(1):39-42
references: 10752515
references: Proteomics. 2006 May;6(9):2865-73
references: 16586433
references: Proteomics Clin Appl. 2007 Feb;1(2):176-84
references: 21136667
references: Biochim Biophys Acta. 1999 Dec 6;1473(1):4-8
references: 10580125
references: Proc Am Thorac Soc. 2011 Sep;8(5):381-5
references: 21926387
references: Anal Bioanal Chem. 2007 Jun;388(3):637-43
references: 17447055
references: Gynecol Oncol. 2006 Jul;102(1):61-6
references: 16403569
references: Clin Cancer Res. 2012 Feb 15;18(4):993-1003
references: 22228641
references: J Cancer. 2012;3:83-92
references: 22359529
references: J Gastrointest Surg. 2008 Oct;12(10):1683-90
references: 18709425
references: Anticancer Res. 2004 Mar-Apr;24(2C):1031-8
references: 15154618
references: Eur J Surg Oncol. 2007 Apr;33(3):266-70
references: 17097848
references: Hepatobiliary Pancreat Dis Int. 2004 May;3(2):292-5
references: 15138129