title: Peripheral neuropathy in cystic fibrosis: a prevalence study.
abstract: BACKGROUND
  Information on peripheral neuropathy in children with cystic fibrosis is scanty. The etiology can be multifactorial (micronutrient deficiency, chronic hypoxia, impaired glucose tolerance, immunological, vasculopathic, critical illness).
  
  
  METHODS
  Forty five cystic fibrosis children aged 1-18 years on vitamin E supplementation for at least 6 months underwent detailed neurological examination, serum vitamin E, vitamin B12, folate, copper levels and detailed nerve conduction studies.
  
  
  RESULTS
  The mean age of the study population was 8.35 years (±4.9 years) with 62.2% being males. Overall 22 out of 45 (48.88%,CI: 33.7-64.2) had electrophysiological evidence of peripheral neuropathy which was predominantly axonal (86.4%), sensory (50%), and polyneuropathy (95.45%). There was no significant association between status of serum micronutrients and electrophysiological evidence of peripheral neuropathy.
  
  
  CONCLUSIONS
  Patients with cystic fibrosis have electrophysiological evidence of peripheral neuropathy (predominantly axonal, sensory and polyneuropathy). There is significant association of higher chronological age with occurrence of peripheral neuropathy.
authors: Department of Pediatrics, All India Institute of Medical Sciences, New Delhi-110029, India.
authors: Biswaroop
authors: B
authors: Chakrabarty
authors: S K
authors: SK
authors: Kabra
authors: Sheffali
authors: S
authors: Gulati
authors: G S
authors: GS
authors: Toteja
authors: Rakesh
authors: R
authors: Lodha
authors: Madhulika
authors: M
authors: Kabra
authors: R M
authors: RM
authors: Pandey
authors: Achal
authors: A
authors: Srivastava
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003300:Copper / Q000097:blood; D003550:Cystic Fibrosis / Q000097:blood / Q000453:epidemiology*; D005260:Female; D005492:Folic Acid / Q000097:blood; D006801:Humans; D007223:Infant; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000453:epidemiology*; D015995:Prevalence; D014805:Vitamin B 12 / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D014810:Vitamin E; D003300:Copper; D005492:Folic Acid; D014805:Vitamin B 12
keywords: Axonal; Cystic fibrosis; Micronutrients; Polyneuropathy; Sensory