title: Combined primary tumor and extracranial metastasis status as constituent factor of prognostic indices for predicting the overall survival in patients with brain metastases.
abstract: We retrospectively analyzed the prognostic factors on overall survival (OS) in patients with brain metastasis (BM) and evaluated the role of combined primary tumor and extracranial metastasis (ECM) status as a constituent factor for prognostic index. This study involved 897 patients with BMs who underwent radiotherapy between April 2003 and December 2009. Among the clinical parameters, multivariate analysis showed that age, Karnofsky performance status (KPS), combined primary tumor and ECM status, number of BMs, and treatment group were significant prognostic factors for OS (P < 0.05). To compare the discriminatory ability of 5 prognostic indices, i.e., recursive partitioning analysis (RPA), basic score for BMs (BSBM), score index for radiosurgery (SIR), graded prognostic assessment (GPA), and modified GPA including the combined primary tumor and ECM status (mGPA), the Akaike information criteria (AIC) were calculated. The mGPA showed the lowest AIC value, followed by RPA, GPA, SIR, and BSBM, in that order. It is implicated that modified score of pre-existing factors (i.e., age and KPS) and addition of the combined primary tumor and ECM status to the prognostic index can improve its discriminatory ability and the combined primary tumor and ECM status may be useful as one of constituent factors for prognostic index.
authors: Research Institute and Hospital, National Cancer Center, Goyang, Korea.
authors: Young Hee
authors: YH
authors: Park
authors: Tae Hyun
authors: TH
authors: Kim
authors: Sun-Young
authors: SY
authors: Jung
authors: Young-Eun
authors: YE
authors: Kim
authors: Jong-Myon
authors: JM
authors: Bae
authors: Yeon-Joo
authors: YJ
authors: Kim
authors: Ji Hoon
authors: JH
authors: Choi
authors: Nam Kwon
authors: NK
authors: Lee
authors: Sung Ho
authors: SH
authors: Moon
authors: Sang Soo
authors: SS
authors: Kim
authors: Kyung Hwan
authors: KH
authors: Shin
authors: Joo-Young
authors: JY
authors: Kim
authors: Dae Yong
authors: DY
authors: Kim
authors: Kwan Ho
authors: KH
authors: Cho
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017567:Karnofsky Performance Status; D008175:Lung Neoplasms / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed
keywords: Brain Metastasis; Prognostic Index; Radiotherapy
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