title: The interaction of imidazole-, imidazolium-, and tetrazolium-containing compounds with DNA.
abstract: The interaction between DNA and members of series of bivalent imidazole compounds, monovalent and bivalent imidazolium compounds, and monovalent and bivalent tetrazolium compounds, which had been synthesized and evaluated for their anti-Plasmodium activity, has been examined using the displacement of SYBR Green I as a measure of competitive binding. The degree of interaction with DNA appears to be dependent on both hydrophobic and charge-pairing interactions.
authors: Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3M2. ian.crandall@utoronto.ca
authors: Ian E
authors: IE
authors: Crandall
authors: Bohang
authors: B
authors: Zhao
authors: Jason Z
authors: JZ
authors: Vlahakis
authors: Walter A
authors: WA
authors: Szarek
mesh_terms: D001667:Binding, Competitive; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology; D013778:Tetrazolium Salts / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D007093:Imidazoles; D013778:Tetrazolium Salts; D004247:DNA