title: Detection of remote neuronal reactions in the Thalamus and Hippocampus induced by rat glioma using the PET tracer cis-4-[¹⁸F]fluoro-D-proline.
abstract: After cerebral ischemia or trauma, secondary neurodegeneration may occur in brain regions remote from the lesion. Little is known about the capacity of cerebral gliomas to induce secondary neurodegeneration. A previous study showed that cis-4-[(18)F]fluoro-D-proline (D-cis-[(18)F]FPro) detects secondary reactions of thalamic nuclei after cortical infarction with high sensitivity. Here we investigated the potential of D-cis-[(18)F]FPro to detect neuronal reactions in remote brain areas in the F98 rat glioma model using ex vivo autoradiography. Although the tumor tissue of F98 gliomas showed no significant D-cis-[(18)F]FPro uptake, we observed prominent tracer uptake in 7 of 10 animals in the nuclei of the ipsilateral thalamus, which varied with the specific connectivity with the cortical areas affected by the tumor. In addition, strong D-cis-[(18)F]FPro accumulation was noted in the hippocampal area CA1 in two animals with ipsilateral F98 gliomas involving hippocampal subarea CA3 rostral to that area. Furthermore, focal D-cis-[(18)F]FPro uptake was present in the necrotic center of the tumors. Cis-4-[(18)F]fluoro-D-proline uptake was accompanied by microglial activation in the thalamus, in the hippocampus, and in the necrotic center of the tumors. The data suggest that brain tumors induce secondary neuronal reactions in remote brain areas, which may be detected by positron emission tomography (PET) using D-cis-[(18)F]FPro.
authors: Institute of Neuroscience and Medicine, INM-4-Medical Imaging Physics, Research Centre Jülich, Jülich, Germany.
authors: Stefanie
authors: S
authors: Geisler
authors: Antje
authors: A
authors: Willuweit
authors: Michael
authors: M
authors: Schroeter
authors: Karl
authors: K
authors: Zilles
authors: Kurt
authors: K
authors: Hamacher
authors: Norbert
authors: N
authors: Galldiks
authors: Nadim J
authors: NJ
authors: Shah
authors: Heinz H
authors: HH
authors: Coenen
authors: Karl-Josef
authors: KJ
authors: Langen
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000379:methods; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005910:Glioma / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006624:Hippocampus / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D011916:Rats, Inbred F344; D013788:Thalamus / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: C431803:fluoro-proline; D011392:Proline
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