title: Sensitivity and specificity of detecting reticular pseudodrusen in multimodal imaging in Japanese patients.
abstract: OBJECTIVE
  To identify reticular pseudodrusen (RPD) in age-related macular degeneration using multiple imaging modalities, including the blue channel image of fundus photography, infrared reflectance (IR), fundus autofluorescence, near-infrared fundus autofluorescence, confocal blue reflectance, indocyanine green angiography, and spectral-domain optical coherence tomography (SD-OCT), and to compare the sensitivities and specificities of these modalities for detecting RPD.
  
  
  METHODS
  This study included 220 eyes from 114 patients with newly diagnosed age-related macular degeneration. Patients underwent fundus photography, IR, fundus autofluorescence, near-infrared fundus autofluorescence, confocal blue reflectance, indocyanine green angiography, and SD-OCT in both eyes. Eyes were diagnosed with RPD if they showed reticular patterns on at least two of the seven imaging modalities.
  
  
  RESULTS
  Thirty-seven eyes were diagnosed with RPD. However, SD-OCT and IR had the highest sensitivity (94.6%), and at the same time, SD-OCT had a high specificity (98.4%). The blue channel of color fundus photography, confocal blue reflectance, and indocyanine green angiography had a specificity of 100% but had lower sensitivity than that of SD-OCT and IR.
  
  
  CONCLUSIONS
  For detecting RPD, IR and SD-OCT had the highest sensitivity. Although SD-OCT had the highest sensitivity and specificity, RPD detection should be confirmed using more than one modality for increased accuracy.
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: Naoko
authors: N
authors: Ueda-Arakawa
authors: Sotaro
authors: S
authors: Ooto
authors: Akitaka
authors: A
authors: Tsujikawa
authors: Kenji
authors: K
authors: Yamashiro
authors: Akio
authors: A
authors: Oishi
authors: Nagahisa
authors: N
authors: Yoshimura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology; D004396:Coloring Agents; D003941:Diagnostic Techniques, Ophthalmological; D005189:False Positive Reactions; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D007564:Japan / Q000453:epidemiology; D008268:Macular Degeneration / Q000175:diagnosis* / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D010781:Photography; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D015593:Retinal Drusen / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green