title: CD8(+) lymphocytes suppress human immunodeficiency virus 1 replication by secreting type I interferons.
abstract: CD8(+) cells can suppress human immunodeficiency virus 1 (HIV-1) replication by releasing soluble factors. In 26 years of intensive research efforts, the identity of the major CD8(+) cell antiviral factor has remained elusive. To investigate the mechanism for this antiviral immune response, we performed gene expression analyses on primary CD4(+) cells that were exposed to HIV-suppressing CD8(+) cells or CD8(+) cell-conditioned medium having HIV-suppressing activity. These experiments revealed increased levels of multiple genes stimulated by type I interferons (IFN; eg, IFN-α and IFN-β). Further evaluation revealed that primary CD8(+) cells, particularly those from elite controllers and other asymptomatic HIV-1-infected individuals, secrete IFN, and this response directly contributes to the in vitro suppression of HIV replication in CD4(+) cells. This novel immune response, likely mediated by memory CD8(+) T cells, may play an important role in a wide variety of viral infections, cancers, and autoimmune diseases.
authors: 1 Department of Medicine, University of California San Francisco , San Francisco, California.
authors: M Scott
authors: MS
authors: Killian
authors: Fernando
authors: F
authors: Teque
authors: Robert L
authors: RL
authors: Walker
authors: Paul S
authors: PS
authors: Meltzer
authors: J Keith
authors: JK
authors: Killian
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D015497:HIV-1 / Q000254:growth & development* / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000276:immunology* / Q000378:metabolism*; D008297:Male; D014779:Virus Replication / Q000276:immunology*
chemical_list: D007370:Interferon Type I
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