title: Seminal plasma adipokine levels are correlated with functional characteristics of spermatozoa.
abstract: OBJECTIVE
  To study adipokines as a potential link between obesity and male subfertility.
  
  
  METHODS
  Cross-sectional study of subjects stratified into subgroups according to body mass index (BMI): normal-weight (18.50-24.99 kg/m(2)), overweight (25-29.99 kg/m(2)), and obese (>30 kg/m(2)).
  
  
  METHODS
  Leipzig, Germany from 2007 to 2011.
  
  
  METHODS
  Ninety-six male volunteers without spermatogenesis-associated diseases.
  
  
  METHODS
  None.
  
  
  METHODS
  Semen parameters, reproductive hormones in serum, and leptin, adiponectin, resistin, chemerin, progranulin, vaspin, and visfatin concentrations in serum and seminal plasma.
  
  
  RESULTS
  All measured adipokines were detectable in human seminal plasma. The levels of progranulin, visfatin, and vaspin were statistically significantly higher in seminal plasma than in serum. An increase in body weight was associated with decreased levels of seminal plasma progranulin. Additionally, overweight/obese men had statistically significantly lower progranulin levels in seminal plasma than normal weight men. Adiponectin and progranulin concentrations in seminal plasma statistically significantly positively correlated with sperm concentration, sperm count, and total normomorphic spermatozoa.
  
  
  CONCLUSIONS
  Adipokines are differently regulated in human male reproductive tract compared with the peripheral blood, and they could influence sperm functionality.
authors: Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
authors: Stephanie
authors: S
authors: Thomas
authors: Dorothea
authors: D
authors: Kratzsch
authors: Michael
authors: M
authors: Schaab
authors: Markus
authors: M
authors: Scholz
authors: Sonja
authors: S
authors: Grunewald
authors: Joachim
authors: J
authors: Thiery
authors: Uwe
authors: U
authors: Paasch
authors: Juergen
authors: J
authors: Kratzsch
mesh_terms: D054392:Adipokines / Q000097:blood* / Q000378:metabolism*; D052242:Adiponectin / Q000097:blood / Q000378:metabolism; D000328:Adult; D001835:Body Weight / Q000502:physiology; D018925:Chemokines / Q000097:blood / Q000378:metabolism; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D005298:Fertility / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000378:metabolism; D020738:Leptin / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood / Q000378:metabolism; D009765:Obesity / Q000378:metabolism; D050177:Overweight / Q000378:metabolism; D000077153:Progranulins; D052243:Resistin / Q000097:blood / Q000378:metabolism; D012661:Semen / Q000378:metabolism*; D015843:Serpins / Q000097:blood / Q000378:metabolism; D013094:Spermatozoa / Q000166:cytology / Q000502:physiology*; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D018925:Chemokines; D016207:Cytokines; C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D000077153:Progranulins; C478630:RARRES2 protein, human; C499624:RETN protein, human; D052243:Resistin; C507339:SERPINA12 protein, human; D015843:Serpins; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human