title: Therapeutic hints from analyzing the attractor landscape of the p53 regulatory circuit.
abstract: Genes are interconnected in the cell to form a genetic network that regulates cell fate. Targeting multiple genes is expected to be more effective in developing therapeutics than targeting single genes. A recent study demonstrated the possibility of systematically searching for such combinatorial treatments by characterizing the attractor landscape of the p53 regulatory circuit.
authors: Department of Chemistry and Biochemistry and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093-0359, USA. wei-wang@ucsd.edu
authors: Wei
authors: W
authors: Wang
mesh_terms: D059447:Cell Cycle Checkpoints / Q000502:physiology*; D016923:Cell Death / Q000502:physiology*; D004249:DNA Damage / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53