title: Structure-relaxivity relationships of serum albumin targeted MRI probes based on a single amino acid Gd complex.
abstract: The Gd(III) complex of DO3A-N-α-aminopropionate, Gd(DOTAla), was used to generate a small library of putative MRI probes targeted to human serum albumin (HSA). Ten compounds were synthesized via multistep organic synthesis, and the corresponding Gd complexes were investigated for their affinity to HSA, lipophilicity, and relaxivity in the absence and presence of HSA. Negative charge and moderate lipophilicity correlate with increased HSA affinity and relaxivity.
authors: The Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Suite 2301, Charlestown, Massachusetts 02129, United States.
authors: Eszter
authors: E
authors: Boros
authors: Peter
authors: P
authors: Caravan
mesh_terms: D000409:Alanine / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry; D005682:Gadolinium; D008279:Magnetic Resonance Imaging; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; C546757:Gd(DO3A-N-alpha-aminopropionate); D012709:Serum Albumin; D005682:Gadolinium; D000409:Alanine
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