title: [Biological monitoring and exposure to silica: application of new dose and effect biomarkers].
abstract: Si-CAE was measured in 16 composite marble industry workers furthermore, a spirometry was performed and 8oxoGua, 8oxoGuo 8oxodGuo, SP-A, SP-D, CC16 and HO-1 were dosed. A lower spirometric values (FEV1 and FVC) were observed among workers compared with controls and the following markers were increased: Si-CAE, 8oxoGuo and HO-1 expression. This study shows that exposure to silica can increase the levels of Si-CAE, which can be used to estimate the dose to the target. Finally, nonspecific spirometric abnormalities and an increase in biomarkers of effect were observed.
authors: Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Sez. di Medicina del Lavoro, Università di Parma, Italy. sabbadinimd@gmail.com
authors: F
authors: F
authors: Sabbadini
authors: M
authors: M
authors: Corradi
authors: M
authors: M
authors: Goldoni
authors: G
authors: G
authors: De Palma
authors: P
authors: P
authors: Gergelova
authors: I C
authors: IC
authors: Toma
authors: R
authors: R
authors: Andreoli
authors: P
authors: P
authors: Mozzoni
authors: S
authors: S
authors: Pinelli
authors: R
authors: R
authors: Alinovi
authors: P
authors: P
authors: Apostoli
authors: A
authors: A
authors: Mutti
mesh_terms: D015415:Biomarkers / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis*; D012822:Silicon Dioxide / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D012822:Silicon Dioxide