title: Extracellular thioredoxin: a therapeutic tool to combat inflammation.
abstract: The manipulation of cellular redox status has emerged as a promising therapeutic strategy to prevent uncontrolled inflammatory response. Thioredoxin is an important regulator of cellular redox homeostasis, which catalyzes the reduction of disulfide bonds. Human thioredoxin, originally identified as a secretory protein ADF, has been implicated in a wide variety of redox regulations in both intracellular and extracellular compartments. This review includes a summary of the evidence available supporting the employment of the beneficial properties of thioredoxin to combat inflammation, an evaluation of the potential of redox-based therapy for the treatment of inflammatory diseases, and a discussion on the conceptual model of a redox-sensitive signaling complex, Redoxisome, consisting of thioredoxin and its redox partners.
authors: Department of Bioinspired Science, Ewha Womans University, Seoul, Republic of Korea; Institute for Virus Research, Kyoto University, Kyoto, Japan.
authors: Yoshiyuki
authors: Y
authors: Matsuo
authors: Junji
authors: J
authors: Yodoi
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000378:metabolism*; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013879:Thioredoxins / Q000378:metabolism*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D009363:Neoplasm Proteins; C491203:TXN protein, human; C055533:adult T cell leukemia-derived factor; D013879:Thioredoxins
keywords: Adult T cell leukemia; Biomarker; Inflammation; Redoxisome; Thioredoxin