title: Association between 1603C>T polymorphism of DBH gene and bipolar disorder in a Turkish population.
abstract: OBJECTIVE
  Dopamine-β-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems. Bipolar disorder is a major psychiatric disorder. The present study was designed to explore the associations of polymorphisms of DBH gene in Turkish patients with bipolar disorder.
  
  
  METHODS
  -1021C>T (rs1611115) polymorphism in promoter region, 444G>A (rs1108580) polymorphism in exon 2 and 1603C>T (rs6271; C535R) polymorphism in exon11 of DBH gene were analyzed in 106 patients with bipolar disorder and 106 healthy subjects by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis.
  
  
  RESULTS
  The results showed statistically significant associations for genotypic and allelic distribution between the 1603C>T polymorphism and bipolar disease (p=0.0012 and p=0.034, respectively). There was no association observed between the genotype and allelic frequencies for -1021C>T and 444G>A polymorphisms and bipolar disorder.
  
  
  CONCLUSIONS
  Our data suggests that the 1603C>T polymorphism of the DBH gene is associated with susceptibility to bipolar disorder in a Turkish population.
authors: Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat, Turkey.
authors: Omer
authors: O
authors: Ates
authors: Feryal Cam
authors: FC
authors: Celikel
authors: Serap Erdogan
authors: SE
authors: Taycan
authors: Saime
authors: S
authors: Sezer
authors: Nevin
authors: N
authors: Karakus
mesh_terms: D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D014421:Turkey / Q000453:epidemiology
chemical_list: D004299:Dopamine beta-Hydroxylase