title: Effect of propofol versus sodium thiopental on electroconvulsive therapy in major depressive disorder: a randomized double-blind controlled clinical trial.
abstract: OBJECTIVE
  To compare propofol and sodium thiopental as anesthetic agents for electroconvulsive therapy (ECT) in major depression with respect to clinical effect.
  
  
  METHODS
  Participants were composed of 96 patients with depression who were administered either propofol or sodium thiopental as an anesthetic agent for bilateral ECT. The Hamilton Depression Rating Scale was administered at baseline and after 6 treatments. Algorithm-based charge dosing was used.
  
  
  RESULTS
  There was a statistically significant difference between the groups regarding postintervention Hamilton Depression Rating Scale score. The preintervention mean (SD) scores in the propofol group and the sodium thiopental group were 37.3 (2.2) and 36.7 (1.2), respectively. The postintervention mean (SD) scores in the propofol group and the sodium thiopental group were 10.7 (1.8) and 13.4 (3.3), respectively. No correlation was found between clinical response and age, weight, and body mass index. There was no association between the groups' seizure time and duration of recovery.
  
  
  CONCLUSIONS
  In conclusion, propofol may improve major depressive disorder more than sodium thiopental in patients who are receiving ECT.
authors: Department of Anesthesiology and Reanimation, Gülhane Military Medical Academy, Ankara, Turkey.
authors: Tark
authors: T
authors: Purtuloğlu
authors: Barbaros
authors: B
authors: Özdemir
authors: Murat
authors: M
authors: Erdem
authors: Süleyman
authors: S
authors: Deniz
authors: Adem
authors: A
authors: Balkç
authors: Gazi
authors: G
authors: Ünlü
authors: Taner
authors: T
authors: Öznur
mesh_terms: D000328:Adult; D000367:Age Factors; D000465:Algorithms; D015992:Body Mass Index; D003865:Major Depressive Disorder / Q000523:psychology / Q000628:therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004311:Double-Blind Method; D004565:Electroconvulsive Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D015742:Propofol; D011569:Psychiatric Status Rating Scales; D012640:Seizures / Q000503:physiopathology; D012727:Sex Characteristics; D012959:Socioeconomic Factors; D013874:Thiopental
chemical_list: D006993:Hypnotics and Sedatives; D013874:Thiopental; D015742:Propofol