title: Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives.
abstract: A series of novel indole-imidazole derivatives have been prepared and evaluated in vitro on the aromatase inhibitory activities. The results suggested that proton or a small electron-withdrawing group at para-position of the phenyl ring would enhance the inhibitory activities and any bulky group should be avoided in order to keep a relative small volume for this kind of molecules.
authors: Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
authors: Rui
authors: R
authors: Wang
authors: Hong-Fan
authors: HF
authors: Shi
authors: Jing-Feng
authors: JF
authors: Zhao
authors: Yan-Ping
authors: YP
authors: He
authors: Hong-Bin
authors: HB
authors: Zhang
authors: Jian-Ping
authors: JP
authors: Liu
mesh_terms: D001141:Aromatase / Q000737:chemistry* / Q000378:metabolism; D047072:Aromatase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D015195:Drug Design; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D007211:Indoles / Q000737:chemistry*; D008968:Molecular Conformation; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D047072:Aromatase Inhibitors; D007093:Imidazoles; D007211:Indoles; C029899:imidazole; C030374:indole; D001141:Aromatase