title: Olfactory bulb volume changes in patients with sinonasal polyposis: a magnetic resonance imaging study.
abstract: OBJECTIVE
  The olfactory bulb (OB) is thought to be a plastic structure with highly active afferent neurons. The aim of this study was to evaluate the effect of olfactory deprivation caused by sinonasal polyps on OB volume.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Tertiary university hospital, Department of Otolaryngology.
  
  
  METHODS
  Twenty-two subjects were included: 11 adult patients with bilateral allergic sinonasal polyposis (patient group) and 11 adult healthy controls (control group). Both study groups were matched for age and sex. OB volumes in all study subjects were evaluated in T2-weighted coronal MRI images by planimetric manual contouring.
  
  
  RESULTS
  In the patient group, OB volume measurements ranged from 5.2 to 19.5 mm(3) (mean ± SD, 10.14 ± 3.8). In the control group, volume measurements ranged from 35 to 75.8 mm(3) (mean ± SD, 47.66 ± 10.75). The difference in OB volumes between patient and control groups was statistically significant (P < .001).
  
  
  CONCLUSIONS
  Our study highlights the significant reduction in OB volume in patients with bilateral sinonasal polyposis as compared with its volume in healthy controls. Further studies are required to evaluate the impact of OB volume reduction on olfactory recovery postoperatively.
authors: Department of Otolaryngology, Faculty of Medicine, Zagazig University, Egypt. iherzallah@gmail.com
authors: Islam R
authors: IR
authors: Herzallah
authors: Sherif M
authors: SM
authors: Askar
authors: Hazem S
authors: HS
authors: Amer
authors: Ayman F
authors: AF
authors: Ahmed
authors: Mohammad W
authors: MW
authors: El-Anwar
authors: Mohamed H
authors: MH
authors: Eesa
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000175:diagnosis* / Q000473:pathology; D009830:Olfactory Bulb / Q000473:pathology*; D009929:Organ Size; D055815:Young Adult