title: Multifunctional Fe3O4-TiO2 nanocomposites for magnetic resonance imaging and potential photodynamic therapy.
abstract: Multifunctional Fe(3)O(4)-TiO(2) nanocomposites with Janus structure for magnetic resonance imaging (MRI) and potential photodynamic therapy (PDT) were synthesized, in which Fe(3)O(4) was used as a MRI contrast agent and TiO(2) as an inorganic photosensitizer for PDT. Their morphology, structure, and MRI and PDT performance were characterized, respectively. Moreover, the location of Fe(3)O(4)-TiO(2) nanocomposites in MCF-7 cells was also investigated by the staining of Prussian blue and alizarin red, respectively. The results showed that the as-prepared Fe(3)O(4)-TiO(2) nanocomposites had good T(2)-weighted MRI performance, and the MCF-7 cells incubated with nanocomposites could be killed under the irradiation of UV light. Compared with traditional organic photosensitizers, TiO(2) inorganic photosensitizers could have more stable PDT performance due to their nanoscale size and anti-photodegradable stability. Therefore, the as-prepared Fe(3)O(4)-TiO(2) nanocomposites could have potential applications as a new kind of multifunctional agent for both MRI and PDT.
authors: Key Laboratory of Magnetic Materials and Devices, Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
authors: Leyong
authors: L
authors: Zeng
authors: Wenzhi
authors: W
authors: Ren
authors: Lingchao
authors: L
authors: Xiang
authors: Jianjun
authors: J
authors: Zheng
authors: Bin
authors: B
authors: Chen
authors: Aiguo
authors: A
authors: Wu
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D018613:Microscopy, Confocal; D053761:Nanocomposites / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D011859:Radiography; D014025:Titanium / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D017319:Photosensitizing Agents; C009495:titanium dioxide; D014025:Titanium; D052203:Ferrosoferric Oxide