title: Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance.
abstract: Radiation-damaged nanodiamonds (DNDs) are potentially ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their low toxicity and high optical absorbance. PA imaging contrast agents have been limited to quantum dots and gold particles, since most existing carbon-based nanoparticles, including fluorescent nanodiamonds, do not have sufficient optical absorption in the near-infrared (NIR) range. A new DND by He+ ion beam irradiation with very high NIR absorption was synthesized. These DNDs produced a 71-fold higher PA signal on a molar basis than similarly dimensioned gold nanorods, and 7.1 fmol of DNDs injected into rodents could be clearly imaged 3 mm below the skin surface with PA signal enhancement of 567% using an 820-nm laser wavelength.
authors: University of Kansas, Department of Pharmaceutical Chemistry, 2095 Constant Avenue, Lawrence, KS 66047, USA.
authors: Ti
authors: T
authors: Zhang
authors: Huizhong
authors: H
authors: Cui
authors: Chia-Yi
authors: CY
authors: Fang
authors: Long-Jyun
authors: LJ
authors: Su
authors: Shenqiang
authors: S
authors: Ren
authors: Huan-Cheng
authors: HC
authors: Chang
authors: Xinmai
authors: X
authors: Yang
authors: M Laird
authors: ML
authors: Forrest
mesh_terms: D000818:Animals; D002645:Chickens; D003287:Contrast Media; D006046:Gold; D007259:Infrared Rays; D053768:Metal Nanoparticles; D051379:Mice; D058612:Nanodiamonds / Q000528:radiation effects; D036103:Nanotechnology; D043942:Nanotubes; D055096:Optical Devices; D061848:Optical Imaging / Q000295:instrumentation / Q000379:methods*; D055620:Optical Phenomena; D061088:Photoacoustic Techniques / Q000295:instrumentation / Q000379:methods*; D012867:Skin / Q000033:anatomy & histology; D047071:beta-Glucans
chemical_list: D003287:Contrast Media; D058612:Nanodiamonds; D047071:beta-Glucans; C516584:micellapist; D006046:Gold
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