title: Studies in mice reveal a role for anthrax toxin receptors in matrix metalloproteinase function and extracellular  matrix homeostasis.
abstract: The genes encoding Anthrax Toxin Receptors (ANTXRs) were originally identified based on expression in endothelial cells suggesting a role in angiogenesis. The focus of this review is to discuss what has been learned about the physiological roles of these receptors through evaluation of the Antxr knockout mouse phenotypes. Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication.
authors: Department of Ob/Gyn, Columbia University Medical Center, New York, NY 10032, USA. creeves2002@gmail.com
authors: Claire
authors: C
authors: Reeves
authors: Pelisa
authors: P
authors: Charles-Horvath
authors: Jan
authors: J
authors: Kitajewski
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000633:toxicity; D001427:Bacterial Toxins / Q000633:toxicity; D005109:Extracellular Matrix / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D020782:Matrix Metalloproteinases / Q000502:physiology*; D051379:Mice; D009369:Neoplasms / Q000378:metabolism; D018000:Receptors, Peptide / Q000502:physiology*; D012098:Reproduction / Q000502:physiology
chemical_list: D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D018000:Receptors, Peptide; C030325:anthrax toxin; C070309:anthrax toxin receptors; D020782:Matrix Metalloproteinases
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