title: [Opisthorchiasis: tradition and innovation].
abstract: THE PURPOSE OF THE REVIEW: Present new data on the causative agent, pathogenesis, diagnosis and treatment of opisthorchiasis.
  
  
  BACKGROUND
  When samples of parasites were genotyped by novel nuclear marker Pm-int9, it was shown various properties of Opisthorchis viverrini, O. felineus and C. sinensis. It has been proven the oxidant damage to DNA of biliary epithelium cells infected with opisthorchiasis, and overexpressed of cellular protooncogene c-Ski, as well as platelet-derived growth factor alpha (Pdgfa) gene, which in some cases leads to the development of cholangiocarcinoma. Describes the innovations in the diagnosis of opisthorchiasis: primers OP1 and OP2 are used to amplify the ITS2 region rDNK eggs and metacercariae of Opisthorchis in feces. Opisthorchiasis treatment remains traditional - praziquantel, at least - with albendazole. Treatment of opisthorchiasis patients with praziquantel was shown to reduce inflammation-mediated tissue damage and carcinogenesis.
authors: I N
authors: IN
authors: Grigor'eva
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018509:DNA, Helminth / Q000235:genetics; D004359:Drug Therapy, Combination; D005243:Feces / Q000469:parasitology; D006801:Humans; D009889:Opisthorchiasis / Q000453:epidemiology / Q000469:parasitology / Q000628:therapy; D009890:Opisthorchidae / Q000187:drug effects* / Q000302:isolation & purification; D026741:Physical Therapy Modalities; D011223:Praziquantel / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000871:Anthelmintics; D018509:DNA, Helminth; D011223:Praziquantel