title: An aide memoire for model-based drug development--a new key for the interpretation of the erythromycin breath test--therapeutic index as a biomarker for smart drug development.
authors: Clinical Pharmacology Department, Shire AG, Business Park Terre-Bonne, Route de Crassier 15, 1262 Eysins, Switzerland. bbdumont@shire.com
authors: Bruno
authors: B
authors: Boutouyrie-Dumont
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D054316:Biomarkers, Pharmacological; D017277:Drug Approval / Q000379:methods*; D055808:Drug Discovery / Q000379:methods* / Q000639:trends*; D064420:Drug-Related Side Effects and Adverse Reactions; D004917:Erythromycin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D027361:Organic Anion Transporters / Q000235:genetics*; D029362:Organic Anion Transporters, Sodium-Independent / Q000235:genetics*; D009965:Orphan Drug Production / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012107:Research Design / Q000592:standards*
chemical_list: D000900:Anti-Bacterial Agents; D054316:Biomarkers, Pharmacological; D027361:Organic Anion Transporters; D029362:Organic Anion Transporters, Sodium-Independent; D004364:Pharmaceutical Preparations; D004917:Erythromycin