title: One-step synthesis of 5,6-diaryl pyridine-2(1H)-thiones from isoflavones.
abstract: The one-step cyclocondensation of substituted isoflavones with cyanothioacetamide in the presence of sodium hydroxide gave an array of 3-cyano-5,6-diaryl pyridine-2(1H)-thiones in good yields. The procedure involves base-mediated ring opening of the isoflavones and subsequent Knoevenagel condensation between the 1,3-dicarbonyl intermediate generated from the isoflavones and cyanothioacetamide, followed by ring closure and dehydration.
authors: Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, PR China.
authors: Juanjuan
authors: J
authors: Wang
authors: Zunting
authors: Z
authors: Zhang
authors: Wenli
authors: W
authors: Wang
authors: Fangfang
authors: F
authors: Liu
mesh_terms: D018360:Crystallography, X-Ray; D007529:Isoflavones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013871:Thiones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007529:Isoflavones; D011725:Pyridines; D013871:Thiones