title: Mild copper-mediated direct oxidative cross-coupling of 1,3,4-oxadiazoles with polyfluoroarenes by using dioxygen as oxidant.
abstract: CH(3)CN and O(2) do the trick! A copper-mediated direct oxidative cross-coupling of 2-(het)aryl-1,3,4-oxadiazoles with polyhaloarenes under mild reaction conditions has been developed (see scheme). The process provides a concise access to biaryl structures containing polyhaloarenes, which are of interest in the fields of pharmaceuticals and functional materials. Acetonitrile and oxygen play crucial roles.
authors: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
authors: Liang-Hua
authors: LH
authors: Zou
authors: Jakob
authors: J
authors: Mottweiler
authors: Daniel L
authors: DL
authors: Priebbenow
authors: Jun
authors: J
authors: Wang
authors: Jan Alexander
authors: JA
authors: Stubenrauch
authors: Carsten
authors: C
authors: Bolm