title: Serious complications associated with stereotactic ablative radiotherapy and strategies to mitigate the risk.
abstract: The clinical applications of stereotactic body radiotherapy or stereotactic ablative radiotherapy (SABR) for the treatment of primary and metastatic tumours of different organ sites have been expanding rapidly in the recent decade. SABR requires advanced technology in radiotherapy planning and image guidance to deliver a highly conformal ablative dose precisely to targets (or tumours) in the body. Although this treatment modality has shown promising results with regard to tumour control, some serious complications have been observed and reported. In order to achieve a favourable therapeutic ratio, strategies to mitigate the risk of complications must be in place. This overview will summarise the reported serious complications caused by SABR and strategies to mitigate the risk will be discussed.
authors: Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, OH 44106, USA. Simon.Lo@UHhospitals.org
authors: S S
authors: SS
authors: Lo
authors: A
authors: A
authors: Sahgal
authors: E L
authors: EL
authors: Chang
authors: N A
authors: NA
authors: Mayr
authors: B S
authors: BS
authors: Teh
authors: Z
authors: Z
authors: Huang
authors: T E
authors: TE
authors: Schefter
authors: M
authors: M
authors: Yao
authors: M
authors: M
authors: Machtay
authors: B J
authors: BJ
authors: Slotman
authors: R D
authors: RD
authors: Timmerman
mesh_terms: D019583:Dose Fractionation, Radiation; D006801:Humans; D009369:Neoplasms / Q000601:surgery*; D016634:Radiosurgery / Q000009:adverse effects* / Q000379:methods*; D012307:Risk Factors