title: Serum S100B in patients with brain tumours undergoing craniotomy.
abstract: OBJECTIVE
  To determine pre- and postoperative serum S100B concentrations in patients with intracranial tumours that underwent craniotomy and compare the values with healthy controls.
  
  
  METHODS
  An observational, comparative study.
  
  
  METHODS
  Neurosurgical Ward, Jinnah Postgraduate Medical Centre. Karachi, from May 2007 to April 2008.
  
  
  METHODS
  Serum S100B was measured pre- and postoperatively on days 1, 2 and 7 in 18 healthy controls and similar number of patients who underwent craniotomy for intracranial tumours. Mean pre-operative patients and control values were compared using Mann-Whitney (unpaired) or Wilcoxon (paired) tests for comparing between pre- and postoperative values. The p-value was considered significant at < 0.05.
  
  
  RESULTS
  Serum S100B concentrations were significantly higher in patients with mean value of 0.19 ± 0.12 μg/L than in healthy controls (mean 0.03 ± 0.01, p < 0.0005). Significantly raised serum S100B concentrations were observed in all postoperative samples when compared with pre-operative samples. S100B concentrations significantly increased on postoperative day 1 (mean = 0.90 ± 1.07 μg/L, p < 0.0005), decreased on day 2 (mean = 0.84 ± 0.57 μg/L, p < 0.0005). The concentrations further declined on day 7 (mean = 0.44 ± 0.43 μg/L, p = 0.005).
  
  
  CONCLUSIONS
  The significantly high postoperative concentrations of S100B in patients appear as a consequence of tissue damage due to surgical procedures. The absence of fall of the S100B concentration in serum from the peak value on postoperative day 1 and day 2 could provide early warning of brain tissue damage leading to neurological deterioration.
authors: Department of Biochemistry, Jinnah University for Women, Karachi.
authors: Talat
authors: T
authors: Syeda
authors: Abdul Sattar
authors: AS
authors: Muhammad Hashim
authors: Husan Afroz
authors: HA
authors: Rizvi
authors: Syed Murtaza
authors: SM
authors: Hadi
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*; D016022:Case-Control Studies; D003399:Craniotomy; D005260:Female; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D011184:Postoperative Period; D057234:Preoperative Period; D009418:S100 Proteins / Q000097:blood*; D012959:Socioeconomic Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D009418:S100 Proteins