title: [Association of sex, age, renal function, metabolic index and types of diseases with serum cystatin-C in patients].
abstract: OBJECTIVE
  To identify the determinants of serum cystatin-C (Cys C) in patients.
  
  
  METHODS
  The medical records of 31235 patients admitted to West China hospital from September to October, 2009 and their first laboratorial test results were examined. Liner regression analyses were performed to determine the association of sex, age, renal function, and metabolic index serum Cys C. One-way ANOVA and LSD tests were performed to determine the association between different diseases and serum Cys C.
  
  
  RESULTS
  The multiple linear regression equation was obtained: Cys C = 0.331 + 0. 686Crea + 0. 174Urea + 0.119Age + 0. 068Uric - 0. 057HDL-C -0.041Sex + 0.038eGFR -0.031LDL-C -0. 026Glu, with a correlation coefficient of 0. 859 and a coefficient of determination of 0. 738. The level of serum Cys C varied with different diseases, with urinary diseases showing the highest level followed by vascular and respiratory diseases.
  
  
  CONCLUSIONS
  Serum Cys C is associated with renal function, but not with metabolic index. Cys C tends to rise in patients renal function injury.
authors: Department of Laboratorial Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Ji-Bin
authors: JB
authors: Huang
authors: Zhi-Gang
authors: ZG
authors: Huang
authors: Zhi-Yong
authors: ZY
authors: Deng
authors: Li
authors: L
authors: Wang
authors: Cheng-Yao
authors: CY
authors: Jia
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000503:physiopathology*; D007677:Kidney Function Tests; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D055815:Young Adult
chemical_list: D055316:Cystatin C