title: Acquisition-weighted chemical shift imaging improves SLOOP quantification of human cardiac phosphorus metabolites.
abstract: OBJECTIVE
  Phosphorous metabolite ratios in human myocardium were determined by a combination of acquisition weighted CSI and a SLOOP evaluation and the results were compared to corresponding SLOOP experiments using standard CSI.
  
  
  METHODS
  10 healthy subjects were examined at 1.5 T using both standard CSI and acquisition weighted CSI. Both experiments were performed with a similar acquisition time and the same spatial resolution. The PCr/ATP ratio was determined and the localization properties of both experiments were compared.
  
  
  RESULTS
  The PCr/ATP ratio of 2.2±0.4 found for the experiment using acquisition weighted CSI was almost identical to the value of 2.0±0.4 for standard CSI. The sensitivity and the localization properties improved in all subjects using SLOOP evaluation of the acquisition weighted sampling in comparison to the standard CSI acquisition with an average of 3% and 18%, respectively.
  
  
  CONCLUSIONS
  The employment of acquisition weighting allows for a further improvement of the (31)P SLOOP spectroscopy of the human heart.
authors: The Intervention Centre, Oslo University Hospital, Oslo, Norway; Institute of Radiology, University of Würzburg, Würzburg, Germany.
authors: Oliver
authors: O
authors: Geier
authors: Institute of Radiology, University of Würzburg, Würzburg, Germany. Electronic address: weng@roentgen.uni-wuerzburg.de.
authors: Andreas Max
authors: AM
authors: Weng
authors: Institute of Radiology, University of Würzburg, Würzburg, Germany.
authors: Andreas
authors: A
authors: Toepell
authors: Institute of Radiology, University of Würzburg, Würzburg, Germany.
authors: Dietbert
authors: D
authors: Hahn
authors: Department of Internal Medicine, University of Würzburg, Würzburg, Germany.
authors: Matthias
authors: M
authors: Spindler
authors: Institute of Radiology, University of Würzburg, Würzburg, Germany; Department of Pediatric Radiology, Medical University Graz, Graz, Austria.
authors: Meinrad
authors: M
authors: Beer
authors: Institute of Radiology, University of Würzburg, Würzburg, Germany; Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany.
authors: Herbert
authors: H
authors: Köstler
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000328:Adult; D000465:Algorithms; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D057054:Molecular Imaging / Q000379:methods*; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate
keywords: Herzspektroskopie; Myocardium; Myokard; Quantifizierung; cardiac spectroscopy; quantification; räumliche Antwortfunktion; spatial response function