title: Effects of different local cryotherapies on systemic levels of TNF-α, IL-6, and clinical parameters in active rheumatoid arthritis.
abstract: Cryotherapies are frequently used to supplement the rehabilitation of patients with rheumatoid arthritis (RA) owing to their analgesic and anti-inflammatory effects. Forty patients with active RA were recruited and received 10 days of comprehensive therapy with different local cryotherapies. None of the respondents were subjected to biological treatment. They were divided into two groups according to the therapy received: nitrogen vapour at -160 °C (group I) or cold airflow at -30 °C (group II). Levels of tumour necrosis factor α (TNF-α), interleukin 6 (IL-6), disease activity score (DAS28), and functional variables were used to assess the outcomes. After the therapy, both groups exhibited similar improvements. Significant reduction in TNF-α level (nitrogen: p < 0.01; cold air: p < 0.05) and no change in IL-6 were observed. DAS28, the clinical severity of pain, duration of morning stiffness, degree of self-reported fatigue, and health assessment questionnaire (HAQ) scores improved significantly. In addition, the active range of knee extension, time, and the number of steps in the 50-m walk test also clearly got better in both groups. The 10-day comprehensive therapies including different local cryotherapies for the patients with RA cause significant decrease in TNF-α systemic levels, meaningly improve DAS28, HAQ scores, and some functional parameters, but do not change IL-6 levels. However, there were no differences in the effectiveness of either cryotherapy.
authors: Department of Physiotherapy, University School of Physical Education, Królowej Jadwigi str. 27/39, 61871 Poznań, Poland.
authors: Robert
authors: R
authors: Jastrząbek
authors: Anna
authors: A
authors: Straburzyńska-Lupa
authors: Radosław
authors: R
authors: Rutkowski
authors: Wojciech
authors: W
authors: Romanowski
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D017679:Cryotherapy / Q000379:methods*; D005260:Female; D006304:Health Status; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016059:Range of Motion, Articular / Q000502:physiology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
references: Scand J Clin Lab Invest. 1998 Nov;58(7):537-45
references: 9890336
references: J Rehabil Med. 2009 Apr;41(5):338-42
references: 19363566
references: Arthritis Rheum. 2001 Sep;44(9):2009-17
references: 11592361
references: Arthritis Rheum. 2000 Feb;43(2):386-9
references: 10693879
references: Clin Exp Rheumatol. 2005 Sep-Oct;23(5 Suppl 39):S43-52
references: 16273784
references: Rheumatol Int. 2012 Oct;32(10):2987-92
references: 21898070
references: Br J Rheumatol. 1998 Jun;37(6):677-87
references: 9667624
references: Arthritis Rheum. 2003 Feb 15;49(1):29-35
references: 12579591
references: J Rheumatol. 1991 Sep;18(9):1290-7
references: 1757927
references: Arthritis Rheum. 2009 Dec 15;61(12):1726-34
references: 19950325
references: Med Klin (Munich). 2008 Jun 15;103(6):383-8
references: 18548207
references: Scand J Rheumatol. 1988;17(4):263-71
references: 3187457
references: Arthritis Rheum. 1995 Jan;38(1):44-8
references: 7818570
references: Hum Factors. 2004 Summer;46(2):244-51
references: 15359674
references: J Hand Ther. 2004 Apr-Jun;17(2):174-80
references: 15162104
references: Arthritis Care Res (Hoboken). 2012 Jan;64(1):117-21
references: 21560258
references: Pain Physician. 2004 Jul;7(3):395-9
references: 16858479
references: Scand J Rheumatol. 2008 Mar-Apr;37(2):109-12
references: 18415767
references: J Gerontol A Biol Sci Med Sci. 1997 Sep;52(5):M275-85
references: 9310081
references: Cochrane Database Syst Rev. 2002;(2):CD002826
references: 12076454
references: Ann Rheum Dis. 2006 Jan;65(1):30-4
references: 15901635
references: Rheumatology (Oxford). 2003 Aug;42(8):995-1000
references: 12730516
references: J Bone Joint Surg Am. 1995 May;77(5):784-98
references: 7744906
references: Lancet. 2010 Sep 25;376(9746):1094-108
references: 20870100
references: Rehabilitation (Stuttg). 2000 Apr;39(2):93-100
references: 10832164
references: J Rheumatol. 1993 Sep;20(9):1494-9
references: 8164204
references: Clin Exp Rheumatol. 2005 Sep-Oct;23(5 Suppl 39):S14-8
references: 16273780
references: Rheumatology (Oxford). 2001 Jun;40(6):610-4
references: 11426016
references: Res Nurs Health. 1997 Jun;20(3):195-204
references: 9179174
references: Eur J Appl Physiol Occup Physiol. 1996;72(5-6):445-50
references: 8925815
references: Semin Arthritis Rheum. 1994 Oct;24(2):82-90
references: 7839157
references: Arthritis Rheum. 1988 Mar;31(3):315-24
references: 3358796
references: Rheumatol Int. 2006 Apr;26(6):541-4
references: 16079993
references: Ann Rheum Dis. 2009 Apr;68(4):572-8
references: 18413439
references: Am J Physiol Regul Integr Comp Physiol. 2001 Jul;281(1):R66-75
references: 11404280
references: Ann Rheum Dis. 1985 Nov;44(11):805
references: 2415072
references: Arthritis Care Res. 1993 Sep;6(3):156-66
references: 8130292
references: Best Pract Res Clin Rheumatol. 2009 Feb;23(1):103-16
references: 19233050
references: Joint Bone Spine. 2012 Mar;79(2):117-8
references: 22119347
references: Clin Exp Rheumatol. 2006 May-Jun;24(3):295-301
references: 16870097
references: Clin Physiol. 2000 Mar;20(2):114-21
references: 10735978