title: [Identification of metabolites of arbidol by ultra-high performance liquid chromatography tandem mass spectrometry].
abstract: UPLC-MS-MS system was used for the identification of arbidol metabolites in the rat feces, urine and plasma samples. The system was so powerful a way with high ability of separation and analysis, based on both chromatography and mass properties. The isotope of Br was also a good indicator for metabolites finding. There were altogether 9 metabolites detected and identified, including 2 phase I biotransformation products and 7 phase II ones. It is concluded that arbidol mainly undergo metabolic reactions such as N-demethylation, S-oxidation, glucuronidation and sulfation in rats.
authors: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors: Xiao
authors: X
authors: Liu
authors: Huan
authors: H
authors: Li
authors: Kai-Shun
authors: KS
authors: Bi
authors: Xiao-Hui
authors: XH
authors: Chen
authors: Hao
authors: H
authors: Cai
authors: Bao-Chang
authors: BC
authors: Cai
mesh_terms: D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry; D005260:Female; D007211:Indoles / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D053719:Tandem Mass Spectrometry; D013440:Sulfides
chemical_list: D007211:Indoles; C086979:umifenovir; D013440:Sulfides