title: Mild oxidation of thiofunctional polymers to cytocompatible and stimuli-sensitive hydrogels and nanogels.
abstract: Nanogels consist of three dimensionally cross-linked hydrophilic polymer chains and can thus be easily modified through functionalization of the polymeric building blocks, for example to yield stimuli-sensitive materials. For drug transport and intracellular release, redox-sensitive systems are especially of interest, as the intracellular space is reductive. In this study, parameters that allow preparation of nanogels with tunable size between 150 and 350 nm are systematically evaluated and identified. Most importantly, a new and mild oxidation catalyst, alloxan, is introduced for the preparation of the nanogels. This broadens the range of possible payloads to more-sensitive molecules. Particle stability, degradation in cytosolic conditions, and cytocompatibility in concentrations up to 10 mg · mL(-1) are demonstrated.
authors: DWI e.V. and Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstr. 50, 52074 Aachen, Germany.
authors: Smriti
authors: S
authors: Singh
authors: Ilona
authors: I
authors: Zilkowski
authors: Andrea
authors: A
authors: Ewald
authors: Tobias
authors: T
authors: Maurell-Lopez
authors: Krystyna
authors: K
authors: Albrecht
authors: Martin
authors: M
authors: Möller
authors: Jürgen
authors: J
authors: Groll
mesh_terms: D000496:Alloxan / Q000737:chemistry; D001704:Biopolymers / Q000737:chemistry*; D002384:Catalysis; D016503:Drug Delivery Systems / Q000379:methods*; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D008301:Maleimides; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D000080385:Nanogels; D036103:Nanotechnology; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013057:Spectrum Analysis; D013059:Spectrum Analysis, Raman
chemical_list: C504424:Alexa Fluor 488 C5-maleimide; D001704:Biopolymers; D020100:Hydrogels; D008301:Maleimides; D000080385:Nanogels; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D000496:Alloxan; D011094:Polyethyleneimine