title: Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study.
abstract: BACKGROUND
  Lectin complement pathway (LP) activation is an important mechanism in myocardial ischemia reperfusion injury (IRI). LP is activated via the recognition molecules mannose-binding lectin (MBL), ficolins-2 and-3 and is regulated by MBL/Ficolin-associated Protein-1 (MAP-1). Also, C-reactive protein (CRP) and ficolin-2 interact in vitro, but the role of the ficolins in IRI is unknown.
  
  
  RESULTS
  In 55 patients with ST segment elevation myocardial infarction, we investigated the association of LP components and CRP in plasma samples with left ventricular (LV) end systolic and diastolic volumes (ESV and EDV) and infarct size, assessed by cardiac magnetic resonance early at 1-3 days after primary percutaneous coronary intervention and at 6 months follow-up. Opposed to MBL, ficolin-3 and MAP-1, ficolin-2 levels were low at baseline. At baseline, ficolin-2>median was associated with ESV and EDV increases by 7.83 ml/m(2) (p=0.004) and 14.04 ml/m(2) (p<0.001). MBL and MAP-1 were not associated with LV dilatation, yet ficolin-2 and MBL worked synergistically and the combination of their levels>median was associated with ESV (11.21 ml/m(2); p=0.017) and EDV increases (14.72 ml/m(2); p=0.006). MAP-1<median+ficolin-2>median had the greatest LV dilatation (17.61 ml/m(2)). The ficolin-2 × CRP interaction variable was positively associated with infarct size and inversely associated with EDV change over 6 months (p=0.006). There was no interaction between CRP and the other LP molecules.
  
  
  CONCLUSIONS
  The LP initiator molecule ficolin-2 and combinations of ficolin-2, MBL and MAP-1 are associated with LV dilatation after myocardial infarction. Interaction of ficolin-2 and CRP was associated with infarct size and LV remodeling, indicating a potential role for LP and LP-pentraxin cross-activation in IRI and LV remodeling.
authors: Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Denmark. mikkel.schoos@gmail.com
authors: Mikkel Malby
authors: MM
authors: Schoos
authors: Lea
authors: L
authors: Munthe-Fog
authors: Mikkel-Ole
authors: MO
authors: Skjoedt
authors: Rasmus Sejersten
authors: RS
authors: Ripa
authors: Jacob
authors: J
authors: Lønborg
authors: Jens
authors: J
authors: Kastrup
authors: Henning
authors: H
authors: Kelbæk
authors: Peter
authors: P
authors: Clemmensen
authors: Peter
authors: P
authors: Garred
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D037582:Complement Pathway, Mannose-Binding Lectin / Q000502:physiology*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D037241:Mannose-Binding Lectins / Q000378:metabolism; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D020257:Ventricular Remodeling / Q000502:physiology*; D000097604:Ficolins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D002097:C-Reactive Protein; D006023:Glycoproteins; D037102:Lectins; D037241:Mannose-Binding Lectins; D000097604:Ficolins; C109662:FCN3 protein, human; C428449:MOAP1 protein, human