title: Evaluation of antioxidant activities of water-soluble polysaccharides from brown alga Hizikia fusiformis.
abstract: Water-soluble polysaccharides were isolated from the brown alga Hizikia fusiformis and separated using hydrophobic chromatography on an ME-1 resin column. Three major polysaccharide fractions, FG, GM-1 and GM-2, were analyzed by high-performance liquid chromatography, Fourier-transform infrared and (13)C nuclear magnetic resonance spectroscopy. These three fractions showed free radical scavenging activity against hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl radical in vitro. Among these three fractions, GM-2 had the best free radical scavenging activity. Thus, only GM-2 was used in the acute oxidative stress experiments in the CCl₄-induced liver injury model. GM-2 also protected against oxidative injury induced by CCl₄in vivo.
authors: Zhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
authors: Mingjiang
authors: M
authors: Wu
authors: Yue
authors: Y
authors: Wu
authors: Min
authors: M
authors: Qu
authors: Wei
authors: W
authors: Li
authors: Xiufeng
authors: X
authors: Yan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D001713:Biphenyl Compounds / Q000378:metabolism; D002251:Carbon Tetrachloride; D016166:Free Radical Scavengers / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control; D051379:Mice; D000459:Phaeophyceae / Q000737:chemistry*; D010851:Picrates / Q000378:metabolism; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000494:pharmacology; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D011134:Polysaccharides; D020011:Protective Agents; D014867:Water; D017665:Hydroxyl Radical; D002251:Carbon Tetrachloride; C004931:1,1-diphenyl-2-picrylhydrazyl