title: Genomes on the edge: programmed genome instability in ciliates.
abstract: Ciliates are an ancient and diverse group of microbial eukaryotes that have emerged as powerful models for RNA-mediated epigenetic inheritance. They possess extensive sets of both tiny and long noncoding RNAs that, together with a suite of proteins that includes transposases, orchestrate a broad cascade of genome rearrangements during somatic nuclear development. This Review emphasizes three important themes: the remarkable role of RNA in shaping genome structure, recent discoveries that unify many deeply diverged ciliate genetic systems, and a surprising evolutionary "sign change" in the role of small RNAs between major species groups.
authors: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.
authors: John R
authors: JR
authors: Bracht
authors: Wenwen
authors: W
authors: Fang
authors: Aaron David
authors: AD
authors: Goldman
authors: Egor
authors: E
authors: Dolzhenko
authors: Elizabeth M
authors: EM
authors: Stein
authors: Laura F
authors: LF
authors: Landweber
mesh_terms: D005075:Biological Evolution; D016798:Ciliophora / Q000235:genetics*; D018503:Genome, Protozoan; D042822:Genomic Instability; D062085:RNA, Long Noncoding / Q000235:genetics; D016053:RNA, Protozoan / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding; D016053:RNA, Protozoan; D022661:RNA, Untranslated
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