title: Female reproductive health after childhood, adolescent, and young adult cancers: guidelines for the assessment and management of female reproductive complications.
abstract: OBJECTIVE
  As more young female patients with cancer survive their primary disease, concerns about reproductive health related to primary therapy gain relevance. Cancer therapy can often affect reproductive organs, leading to impaired pubertal development, hormonal regulation, fertility, and sexual function, affecting quality of life.
  
  
  METHODS
  The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer (COG-LTFU Guidelines) are evidence-based recommendations for screening and management of late effects of therapeutic exposures. The guidelines are updated every 2 years by a multidisciplinary panel based on current literature review and expert consensus.
  
  
  RESULTS
  This review summarizes the current task force recommendations for the assessment and management of female reproductive complications after treatment for childhood, adolescent, and young adult cancers. Experimental pretreatment as well as post-treatment fertility preservation strategies, including barriers and ethical considerations, which are not included in the COG-LTFU Guidelines, are also discussed.
  
  
  CONCLUSIONS
  Ongoing research will continue to inform COG-LTFU Guideline recommendations for follow-up care of female survivors of childhood cancer to improve their health and quality of life.
authors: St Jude Children’s Research Hospital, Memphis, TN, USA. monika.metzger@stjude.org
authors: Monika L
authors: ML
authors: Metzger
authors: Lillian R
authors: LR
authors: Meacham
authors: Briana
authors: B
authors: Patterson
authors: Jacqueline S
authors: JS
authors: Casillas
authors: Louis S
authors: LS
authors: Constine
authors: Nobuko
authors: N
authors: Hijiya
authors: Lisa B
authors: LB
authors: Kenney
authors: Marcia
authors: M
authors: Leonard
authors: Barbara A
authors: BA
authors: Lockart
authors: Wendy
authors: W
authors: Likes
authors: Daniel M
authors: DM
authors: Green
mesh_terms: D000293:Adolescent; D000359:Aftercare; D002648:Child; D004992:Ethics, Medical; D005260:Female; D006058:Gonadal Disorders / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D009369:Neoplasms / Q000628:therapy*; D017410:Practice Guidelines as Topic; D011629:Puberty, Precocious / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D011788:Quality of Life; D060728:Reproductive Health; D012735:Sexual Dysfunction, Physiological / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D055815:Young Adult
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