title: [Continuous infusion of vancomycin in pediatric critical care].
abstract: Continuous infusion of vancomycin may be a strategy for critically ill patients who do not achieve adequate plasma levels. There is few literature on this dosage regimen. We present six children (2 months to 7 years, 4 male and 2 female), admitted to the Intensive Care Unit of the "Prof. Dr. Garrahan Children Hospital", with methicillin-resistant Staphylococcus aureus sepsis, treated with vancomycin 40 and 60 mg/kg/day every 8-6 hrs. Continuous infusion at 50 mg/kg/day was implemented due to poor outcome, persistent fever, positive cultures and inadequate vancomycin plasma levels. All patients achieved levels between 10 and 25 ug/ml, their outcome was favorable and cultures became negative, with no signs of nephrotoxicity. Treatment duration of the continuous infusion was 9 to 18 days. Continuous infusion of vancomycin was effective in these patients without evidence of associated nephrotoxicity.
authors: Hospital de Pediatría Prof. Dr. Juan P. Garrahan. brenda.zylbersztajn@gmail.com
authors: Brenda Lara
authors: BL
authors: Zylbersztajn
authors: Pamela
authors: P
authors: Chicco
authors: Laura
authors: L
authors: Vega
authors: Mónica
authors: M
authors: Centeno
authors: Silvia
authors: S
authors: Filippini
authors: Silvina
authors: S
authors: Ruvinsky
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood; D002648:Child; D003422:Critical Care; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D014640:Vancomycin / Q000008:administration & dosage* / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin