title: Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock.
abstract: Oxymatrine (OMT), an alkaloid extracted from Sophora japonica (kushen), is used to treat inflammatory diseases and various types of cancer in traditional Chinese medicine. However, the cellular and molecular mechanisms underlying the anti‑inflammatory activity of OMT remain poorly understood. The present study explored the protective effect of OMT on myocardial injury in rats with septic shock by inhibiting the activation of the janus kinase‑signal transducer and activator of transcription (JAK/STAT) signaling pathway. OMT treatment was found to significantly inhibit the activation of JAK2 and STAT3 in myocardial tissue. It also attenuated the expression of pro‑inflammatory cytokines, including interleukin‑1β and tumor necrosis factor‑α. In addition, OMT exhibited anti‑inflammatory properties as heart function and myocardial contractility was improved and pathological and ultrastructural injury was prevented in myocardial tissue induced by septic shock. The results indicate that OMT exhibits substantial therapeutic potential for the treatment of septic shock‑induced myocardial injury through inhibition of the JAK2/STAT3 signaling pathway.
authors: Department of Pathophysiology and Neurobiology, Basic Medical College, Center of Scientific Technology, Ningxia Medical University, Yinchuan 750004, P.R. China.
authors: Minghao
authors: M
authors: Zhang
authors: Xiuyu
authors: X
authors: Wang
authors: Xiumei
authors: X
authors: Wang
authors: Xiaolin
authors: X
authors: Hou
authors: Peng
authors: P
authors: Teng
authors: Yideng
authors: Y
authors: Jiang
authors: Linna
authors: L
authors: Zhang
authors: Xiaoling
authors: X
authors: Yang
authors: Jue
authors: J
authors: Tian
authors: Guizhong
authors: G
authors: Li
authors: Jun
authors: J
authors: Cao
authors: Hua
authors: H
authors: Xu
authors: Yunhong
authors: Y
authors: Li
authors: Yin
authors: Y
authors: Wang
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage* / Q000737:chemistry; D000818:Animals; D006335:Heart Injuries / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism; D053614:Janus Kinase 2 / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry; D011807:Quinolizines / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D012772:Shock, Septic / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D029909:Sophora / Q000737:chemistry; D000093842:Matrines
chemical_list: D000470:Alkaloids; D053583:Interleukin-1beta; D053614:Janus Kinase 2; D010936:Plant Extracts; D011807:Quinolizines; D050796:STAT3 Transcription Factor; C494088:Stat3 protein, rat; C037573:oxymatrine; D000093842:Matrines; C507927:Jak2 protein, rat