title: HDAC3 regulates stability of estrogen receptor α mRNA.
abstract: Estrogen receptor alpha (ERα) expression is a risk factor for breast cancer. HDAC inhibitors have been demonstrated to down-regulate ERα expression in ERα-positive breast cancer cell lines, but the molecular mechanisms are poorly understood. Here, we showed that HDAC inhibitors decrease the stability of ERα mRNA, and that knockdown of HDAC3 decreases the stability of ERα mRNA and suppresses estrogen-dependent proliferation of ERα-positive MCF-7 breast cancer cells. In the Oncomine database, expression levels of HDAC3 in ERα-positive tumors are higher than those in ERα-negative tumors, thus suggesting that HDAC3 is necessary for ERα mRNA stability, and is involved in the estrogen-dependent proliferation of ERα-positive tumors.
authors: Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan.
authors: Shohei
authors: S
authors: Oie
authors: Kazuya
authors: K
authors: Matsuzaki
authors: Wataru
authors: W
authors: Yokoyama
authors: Akiko
authors: A
authors: Murayama
authors: Junn
authors: J
authors: Yanagisawa
mesh_terms: D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics; D045744:Cell Line, Tumor; D047628:Estrogen Receptor alpha / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006655:Histone Deacetylases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D020871:RNA Stability; D012333:RNA, Messenger / Q000737:chemistry*; D000099186:Histone Deacetylase 3
chemical_list: D047628:Estrogen Receptor alpha; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases; D012333:RNA, Messenger; D000099186:Histone Deacetylase 3