title: Sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors.
abstract: BACKGROUND
  Depression is common in elderly stroke survivors and has been associated with systemic inflammation. We aimed to investigate an elderly population of Swedish stroke patients for evidence of sustained peripheral inflammation 18 months post-stroke and to identify if inflammation is associated with post-stroke depression at 18 months post-stroke.
  
  
  METHODS
  The Barthel Index was used to measure the level of impairment in activities of daily living at 3 days post-stroke. Serum concentrations of inflammation markers, ie, C-reactive protein and white cell count, were measured in 149 stroke patients (mean age 81 ± 5.33 years, 35% male) at 18 months post-stroke, and a comparison was made with an age-matched sample of elderly Swedish individuals who had not suffered a stroke. At the same visit, clinical depression was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised criteria. Severity of depression was assessed using the Montgomery-Asberg Depression Rating Scale (MADRS).
  
  
  RESULTS
  Mean C-reactive protein and white cell count levels in stroke patients were significantly elevated at 18 months post-stroke compared with population probands. Disability scores were associated with MADRS depression scores, but C-reactive protein and white cell count were not.
  
  
  CONCLUSIONS
  We found evidence for a sustained peripheral inflammatory response at 18 months post-stroke. C-reactive protein and white cell count were not associated with depression in this study.
authors: School of Psychological Science, La Trobe University, Bundoora, Victoria, Australia. k.noonan@latrobe.edu.au
authors: Kate
authors: K
authors: Noonan
authors: Sheila G
authors: SG
authors: Crewther
authors: Leeanne M
authors: LM
authors: Carey
authors: Michaela C
authors: MC
authors: Pascoe
authors: Thomas
authors: T
authors: Linden
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein; D015897:Comorbidity; D003863:Depression / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D003865:Major Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D007958:Leukocyte Count; D008297:Male; D062072:Patient Acuity; D012737:Sex Factors; D020521:Stroke / Q000097:blood* / Q000453:epidemiology*; D013548:Sweden; D013997:Time Factors
chemical_list: D002097:C-Reactive Protein
keywords: geriatric; inflammatory; ischemia; mood
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