title: Chemopreventive effects of 4-methylthio-3-butenyl Isothiocyanate (Raphasatin) but not curcumin against pancreatic carcinogenesis in hamsters.
abstract: The modifying effects of 4-methylthio-3-butenyl isothiocyanate (MTBITC) and curcumin were investigated in N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamsters. Male 6-week-old Syrian hamsters were subcutaneously injected with 10 mg/kg body weight (b.w.) of BOP four times a week, and fed a diet supplemented with 80 mg/kg diet of MTBITC, equivalent to 4.6 mg/kg b.w./day for the initiation stage or 3.8 mg/kg b.w./day for the postinitiation stage administration, respectively, or 2000 mg/kg diet of curcumin, equivalent to 118.8 mg/kg b.w./day for the initiation stage or 100.8 mg/kg b.w./day for the postinitiation stage administration, respectively. The incidence of combined pancreatic lesions, including atypical hyperplasias and adenocarcinomas, was significantly decreased to 55% (P < 0.05) by the 80 mg/kg diet MTBITC given during the initiation stage as compared to the BOP alone group (85%) but not by the curcumin administration at 16 weeks after the BOP-treatment. In the second study, the multiplicity of combined pancreatic lesions was also significantly decreased to 0.50 ± 0.51 (P < 0.05) by 700 mg/kg diet MTBITC given in the initiation stage (equivalent to 59.0 mg/kg b.w./day) as compared to the BOP alone group (1.10 ± 1.02). Our results indicate that the naturally occurring isothiocyanate MTBITC may exert preventive effects against BOP-initiation of hamster pancreatic carcinogenesis.
authors: Division of Pathology and ‡Biological Safety Research Center, National Institute of Health Sciences , Tokyo 158-8501, Japan.
authors: Toshiya
authors: T
authors: Okamura
authors: Takashi
authors: T
authors: Umemura
authors: Tomoki
authors: T
authors: Inoue
authors: Masako
authors: M
authors: Tasaki
authors: Yuji
authors: Y
authors: Ishii
authors: Yasushi
authors: Y
authors: Nakamura
authors: Eun Young
authors: EY
authors: Park
authors: Kenji
authors: K
authors: Sato
authors: Tomoaki
authors: T
authors: Matsuo
authors: Shigehisa
authors: S
authors: Okamoto
authors: Akiyoshi
authors: A
authors: Nishikawa
authors: Kumiko
authors: K
authors: Ogawa
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D016588:Anticarcinogenic Agents; D002273:Carcinogens / Q000008:administration & dosage; D006224:Cricetinae; D003474:Curcumin / Q000008:administration & dosage*; D004032:Diet; D006965:Hyperplasia; D017879:Isothiocyanates / Q000008:administration & dosage*; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines / Q000008:administration & dosage; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*
chemical_list: C447639:4-(methylthio)-3-butenyl isothiocyanate; D016588:Anticarcinogenic Agents; D002273:Carcinogens; D017879:Isothiocyanates; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine; D003474:Curcumin