title: Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats.
abstract: BACKGROUND
  Resveratrol (trans-3,4',5-trihydroxystilbene) is a naturally occurring phytoalexin produced by plants in response to various stresses. Several studies have shown that resveratrol is present in significant amounts in a variety of human diets, including wines, grapes, berries, and peanuts, and it possesses several beneficial health properties, such as atheroprotective, anti-obesity, anti-cancer, anti-inflammatory and antioxidant activities. In this study, we evaluated the effect of resveratrol on the pathogenesis of obesity and the metabolic profile of nutrients in non-high fat-fed obese OLETF rats.
  
  
  RESULTS
  Although lipid parameters in the serum and liver were not changed, the accumulation of abdominal white adipose tissues was markedly prevented in resveratrol diet-fed OLETF rats after 4 weeks of feeding. The results of the respiratory gas analysis indicated that dietary resveratrol induced the partial enhancement of fat metabolism and sparing actions for carbohydrate and protein at 1 week and 3 weeks of feeding in OLETF rats. Additionally, the adipose mRNA level of carnitine palmitoyltransferase in the resveratrol diet-fed OLETF rats was higher than the control rats after 4 weeks of feeding.
  
  
  CONCLUSIONS
  Our study demonstrated that dietary resveratrol can prevent obesity through a change in the metabolic profile of nutrients in obese OLETF rats.
authors: Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan. knagao@cc.saga-u.ac.jp
authors: Koji
authors: K
authors: Nagao
authors: Tomoyuki
authors: T
authors: Jinnouchi
authors: Shunichi
authors: S
authors: Kai
authors: Teruyoshi
authors: T
authors: Yanagita
mesh_terms: D052436:Adipose Tissue, White / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002334:Carnitine O-Palmitoyltransferase / Q000235:genetics / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D005526:Food, Formulated; D015870:Gene Expression / Q000187:drug effects; D006003:Glycogen / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D055442:Metabolome; D009765:Obesity / Q000378:metabolism* / Q000517:prevention & control*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D020334:Rats, Inbred OLETF; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*; D014280:Triglycerides / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D012333:RNA, Messenger; D013267:Stilbenes; D014280:Triglycerides; D006003:Glycogen; D002784:Cholesterol; D002334:Carnitine O-Palmitoyltransferase; D000077185:Resveratrol
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