title: Schistosoma japonicum: susceptibility of neonate mice born to infected and noninfected mothers following subsequent challenge.
abstract: This study was to investigate the differences between neonate mice born to Schistosoma japonicum-infected mothers and those born to noninfected mothers in subsequent challenge. The intensity of infection (evidenced by worm burden and liver egg burden) and liver immunopathology (number and size of liver granulomas) were significantly reduced in neonates from infected mothers (I.M.) compared with neonates from noninfected mothers (N.M.). Anti-soluble worm antigen of S. japonicum (SWA) IgG could be detected in sera of neonates from I.M. (N.N./I.M.) at 1 week after delivery, remained a plateau for 2 weeks and gradually decreased until 8 weeks of age. Parasite-specific IgM was not detected in sera from N.N./I.M. at any time after delivery. At 6 weeks after infection, the level of anti-SWA IgG in infected neonates from I.M. (I.N./I.M.) was significantly higher than that of infected neonates from N.M. (I.N./N.M.). In addition, production of IFN-γ, IL-12 and TGF-β by cultured splenocytes from I.N./I.M. was significantly increased, while the level of IL-4 was significantly decreased when compared to those from I.N./N.M.. These data demonstrate that congenital exposure to schistosomiasis japonica may render neonatal mice born to I.M. less susceptible to subsequent challenge and result in down-regulation of both infection intensity and immunopathology.
authors: Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors: F
authors: F
authors: Zhao
authors: X
authors: X
authors: Huang
authors: X
authors: X
authors: Hou
authors: Y
authors: Y
authors: Deng
authors: M
authors: M
authors: Wu
authors: F
authors: F
authors: Guan
authors: W
authors: W
authors: Liu
authors: Y
authors: Y
authors: Li
authors: J
authors: J
authors: Lei
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000909:Antibodies, Helminth / Q000097:blood; D002478:Cells, Cultured; D004198:Disease Susceptibility; D015536:Down-Regulation; D005260:Female; D006099:Granuloma / Q000473:pathology; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008099:Liver / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009035:Mothers; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000276:immunology*; D012549:Schistosoma japonicum / Q000276:immunology; D012554:Schistosomiasis japonica / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000097:blood*
chemical_list: D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D016212:Transforming Growth Factor beta; D018664:Interleukin-12; D015847:Interleukin-4