title: [Study of local anaesthetics - part 200 choice of the optimal type of chitosan for the formulation of local anaesthetics of the carbamate type into hydrogels].
abstract: The aim of this examination was a study of hydrogels on the base of various types of the natural polymer chitosan with an assay of local anaesthetics of the carbamate type. The concentration of the gel-creating compound in hydrogels was 2.5%. The study included heptacainiumchloride (HEP), pentacainiumchloride (PEN) and carbisocainiumchloride (CAR). Evaluation was focused on the flow properties of prepared gels and the liberation of drugs from them. Based on the achieved results, the optimal type of biopolymer was determined: PEN - CHIT B, for CAR - CHIT C, while in the case of HEP it was found that chitosan is not suitable as a gel-creating base.
authors: Katedra Farmaceutickej Chémie, Farmaceutická Fakulta, Univerzita Komenského, Bratislava.
authors: Jozef
authors: J
authors: Cižmárik
authors: Zuzana
authors: Z
authors: Vitková
authors: Petra
authors: P
authors: Herdová
mesh_terms: D000779:Anesthetics, Local; D002219:Carbamates; D002626:Chemistry, Pharmaceutical; D048271:Chitosan; D020100:Hydrogels
chemical_list: D000779:Anesthetics, Local; D002219:Carbamates; D020100:Hydrogels; D048271:Chitosan