title: Switch of cadherin expression as a diagnostic tool for Leydig cell tumours.
abstract: Leydig cell tumours comprise about 3% of all testicular tumours. The pathogenesis of Leydig cell tumours is still poorly understood. We investigated testis with Leydig cell hyperplasia and Leydig cell tumours for their expression pattern of P- and N-cadherin. We could show a switch of expression of P- and N-cadherin in Leydig cell hyperplasia and Leydig cell tumours in comparison with normal Leydig cells. Cadherins could be established as a new immunohistochemical marker for this testicular tumour entity; their possible role in tumour genesis will be discussed.
authors: Departments of Pathology.
authors: F
authors: F
authors: Bremmer
authors: S
authors: S
authors: Schweyer
authors: M
authors: M
authors: Martin-Ortega
authors: B
authors: B
authors: Hammerlein
authors: A
authors: A
authors: Strauss
authors: H J
authors: HJ
authors: Radzun
authors: C L
authors: CL
authors: Behnes
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D015870:Gene Expression; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D007984:Leydig Cell Tumor / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D007985:Leydig Cells / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D015703:Antigens, CD; C050361:CDH2 protein, human; D015820:Cadherins
keywords: Immunohistochemistry; Leydig cell tumours; N-cadherin; P-cadherin; cadherin switching