title: AD dementia risk in late MCI, in early MCI, and in subjective memory impairment.
abstract: OBJECTIVE
  To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance.
  
  
  METHODS
  The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study on Aging, Cognition and Dementia in Primary Care Patients) was divided into LMCI, EMCI, SMI, and control subjects by delayed recall performance. These groups were subdivided by the presence of self-reported concerns associated with experienced memory impairment. AD dementia risk was assessed over 6 years.
  
  
  RESULTS
  Across all groups, risk of AD dementia was greatest in LMCI. In those with self-reported concerns regarding their memory impairment, SMI and EMCI were associated with a similarly increased risk of AD dementia. In those subgroups without concerns, SMI was not associated with increased risk of AD dementia, but EMCI remained an at-risk condition.
  
  
  CONCLUSIONS
  SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns.
authors: Department of Psychiatry, University of Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. Electronic address: frank.jessen@ukb.uni-bonn.de.
authors: Frank
authors: F
authors: Jessen
authors: Department of Psychiatry, University of Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
authors: Steffen
authors: S
authors: Wolfsgruber
authors: Institute for Biometrics, Hannover Medical School, Hannover, Germany.
authors: Birgitt
authors: B
authors: Wiese
authors: Department of Psychiatry, Technical University at Munich, Munich, Germany.
authors: Horst
authors: H
authors: Bickel
authors: Department of Psychiatry, Technical University at Munich, Munich, Germany.
authors: Edelgard
authors: E
authors: Mösch
authors: Department of Primary Medical Care, University Medical Center, Hamburg, Germany.
authors: Hanna
authors: H
authors: Kaduszkiewicz
authors: Institute of General Practice, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
authors: Michael
authors: M
authors: Pentzek
authors: Institute of Social Medicine and Occupational Health, University of Leipzig, Leipzig, Germany.
authors: Steffi G
authors: SG
authors: Riedel-Heller
authors: Institute of Social Medicine and Occupational Health, University of Leipzig, Leipzig, Germany.
authors: Tobias
authors: T
authors: Luck
authors: Institute of General Practice, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
authors: Angela
authors: A
authors: Fuchs
authors: Central Institute for Mental Health, Mannheim, Germany.
authors: Siegfried
authors: S
authors: Weyerer
authors: Central Institute for Mental Health, Mannheim, Germany.
authors: Jochen
authors: J
authors: Werle
authors: Department of Primary Medical Care, University Medical Center, Hamburg, Germany.
authors: Hendrik
authors: H
authors: van den Bussche
authors: Department of Primary Medical Care, University Medical Center, Hamburg, Germany.
authors: Martin
authors: M
authors: Scherer
authors: Department of Psychiatry, University of Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
authors: Wolfgang
authors: W
authors: Maier
authors: Department of Psychiatry, University of Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
authors: Michael
authors: M
authors: Wagner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000523:psychology*; D053327:Apolipoprotein E4 / Q000235:genetics; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology*; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012306:Risk; D016019:Survival Analysis
chemical_list: D053327:Apolipoprotein E4
keywords: Alzheimer's disease dementia; Mild cognitive impairment; Prospective cohort study; Risk; Subjective memory impairment