title: [The effect of oral contraceptives on selected parameters of homeostasis in young women with sudden balance disorders].
abstract: BACKGROUND
  The aim of the study was to evaluate the correlation between hormonal contraceptives and sex hormones levels as a possible cause of vertigo related to coagulation disorders and fibrinolyse.
  
  
  METHODS
  The study was conducted on 25 female patients aged 23-39, who were treated at the Department of Otolaryngology and Laryngological Oncology, Medical University of Lodz, due to vertigo. The studied patients were divided into 3 groups: I--7 women that used hormonal contraceptives; II--9 women that no used hormonal contraceptives for the last 6 months; III--9 women who never used contraceptives. The methodology included: an otoneurological and audiological examination, blood tests, levels of fibrinogen, D-dimers, APTT, PT, ALAT, ASPAT and BMI, estradiol and progesterone levels.
  
  
  RESULTS
  In 16 out of the 25 patients the obtained results diverged from normal sex hormones concentration in serum. In each studied group the relation between sex hormones concentration in serum and coagulation and fibrinolyse parameters was proved. The correlation between an increased concentration progesterone and D-dimers was found.
  
  
  CONCLUSIONS
  An increased concentration of estrogens in serum may have an additional negative effect on a possibility of a thromboembolic episode. In the female patients interested in oral contraception, the prophylactic exclusion of risk factors for a thromboembolic disease seems to be vital.
authors: Klinika Otolaryngologii i Onkologii Laryngologicznej II Katedry Otolaryngologii UM w Łodzi, ul. Żeromskiego 113, 90-549 Łódź, Poland.
authors: Joanna
authors: J
authors: Urbaniak
authors: Hanna
authors: H
authors: Zielińska-Bliźniewska
authors: Piotr
authors: P
authors: Pietkiewicz
authors: Jurek
authors: J
authors: Olszewski
mesh_terms: D000328:Adult; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects* / Q000097:blood; D004967:Estrogens / Q000097:blood*; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D004856:Postural Balance / Q000187:drug effects; D011374:Progesterone / Q000097:blood*; D013923:Thromboembolism / Q000097:blood* / Q000139:chemically induced*; D014717:Vertigo / Q000150:complications*; D055815:Young Adult
chemical_list: D003278:Contraceptives, Oral, Hormonal; D004967:Estrogens; D011374:Progesterone