title: Congenital Insensitivity to Pain and Anhydrosis (CIPA) Syndrome; A Report of 4 Cases.
abstract: BACKGROUND
  
  
  
  BACKGROUND
  Congenital insensitivity to pain with anhidrosis (CIPA) is characterized by recurrent episodes of infections and unexplained fever, anhidrosis (inability to sweat), and absence of reaction to noxious stimuli, self-mutilating behavior, mental retardation and damages to oral structures.
  
  
  METHODS
  In this article, we have demonstrated the signs and symptoms of 4 children that refer to the pediatrics department of the Imam Khomeini hospital and assay about their complications with this disease. They mostly presented by recurrent osteomyelitis in their feet that severely controlled by antibiotic therapy and even surgery. They had no pain sensation in spite of deep sore and infection.
  
  
  CONCLUSIONS
  This syndrome can be diagnosed by clinical and paraclinical tests together but it would be better to confirm by genetic test. The diagnosis of this syndrome helps us to try for the better quality of life for the patients and avoid unnecessary amputations.
authors: Department of Pediatrics, Imam Komoini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Khadije
authors: K
authors: Daneshjou
authors: Hanieh
authors: H
authors: Jafarieh
authors: Seyed-Reza
authors: SR
authors: Raaeskarami
keywords: CIPA Syndrome; Congenital Analgesia; Congenital Pain Insensitivity; Osteomyelitis
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