title: Distribution of dopamine receptors D1- and D2-immunoreactive neurons in the dorsal motor nucleus of vagus in rats.
abstract: The dorsal motor nucleus of vagus (DMV) plays an important role in the regulation of gastrointestinal function. Dopamine (DA) exerts potent neuromodulatory effects on the motoneurons in the DMV via dopamine receptors (DRs). However, the distribution of DRs and their neurochemical phenotypes in the DMV are unclear. In the present study, the distribution of DRs D1- and D2-immunoreactive (IR) neurons and their neurochemical phenotypes in the DMV of rats were investigated using a double-labeling immunofluorescence technique combined with confocal microscopy. The results indicated that a considerable quantity of D1 and D2 was expressed throughout the DMV. A large amount of choline acetyltransferase (ChAT)-IR and a few tyrosine hydroxylase (TH)-IR neurons were observed in the DMV. Nearly all of the neurons were also D1-IR and D2-IR. In conclusion, the present study demonstrates the wide distribution of D1 and D2 in the cholinergic and catecholaminergic neurons in the DMV of rats. The DRs might play an important role in the regulation of DA on the activity of cholinergic and catecholaminergic neurons in the DMV.
authors: Key Laboratory for Medical Tissue Regeneration of Henan Province, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
authors: Qing-Qing
authors: QQ
authors: Cai
authors: Li-Fei
authors: LF
authors: Zheng
authors: Rui-Fang
authors: RF
authors: Fan
authors: Hui
authors: H
authors: Lian
authors: Li
authors: L
authors: Zhou
authors: Hai-Yan
authors: HY
authors: Song
authors: Yuan-Yuan
authors: YY
authors: Tang
authors: Xiao-Yan
authors: XY
authors: Feng
authors: Zhi-Kun
authors: ZK
authors: Guo
authors: Zhi-Yong
authors: ZY
authors: Wang
authors: Jin-Xia
authors: JX
authors: Zhu
mesh_terms: D000818:Animals; D007120:Immunochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000032:analysis / Q000096:biosynthesis*; D017448:Receptors, Dopamine D2 / Q000032:analysis / Q000096:biosynthesis*; D014630:Vagus Nerve / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2