title: Association between plasma biomarkers, CDK5 polymorphism and the risk of Alzheimer's disease.
abstract: In this study we evaluated biochemical blood serum parameters and the association of Cyclin-dependent kinase 5 (CDK5) gene polymorphisms with the risk of Alzheimer's disease (AD) in the Polish population. We observed an elevated total cholesterol, low-density lipoproteins (LDL) and homocysteine levels and lower concentrations of high-density lipoproteins (HDL) and vitamin B12 in AD patients. However, the analyzed CDK5 polymorphisms were not associated with the biochemical parameters. Moreover, we found no association between the studied polymorphisms and the risk of AD in the Polish population. The meta-analysis of previously published and current study was performed. In conclusion, our study demonstrated that alteration of cholesterol, LDL, HDL, homocysteine and B12 concentration may be an important factor in pathogenesis of AD.
authors: Department of Cellular Signaling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland. gczapski@imdik.pan.pl.
authors: Grzegorz A
authors: GA
authors: Czapski
authors: Aleksandra
authors: A
authors: Maruszak
authors: Maria
authors: M
authors: Styczyńska
authors: Cezary
authors: C
authors: Żekanowski
authors: Krzysztof
authors: K
authors: Safranow
authors: Joanna B
authors: JB
authors: Strosznajder
mesh_terms: D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D051360:Cyclin-Dependent Kinase 5 / Q000097:blood* / Q000235:genetics*; D005260:Female; D005492:Folic Acid / Q000097:blood; D056726:Genetic Association Studies; D005838:Genotype; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012256:Riboflavin / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D008055:Lipids; D006710:Homocysteine; D005492:Folic Acid; D051360:Cyclin-Dependent Kinase 5; D012256:Riboflavin