title: Adipose tissue arachidonic acid content is associated with the risk of myocardial infarction: a Danish case-cohort study.
abstract: OBJECTIVE
  The primary aim of the study was to evaluate the association between adipose tissue arachidonic acid (AA) content and the risk of myocardial infarction (MI). The secondary aim was to assess the correlation between adipose tissue AA and dietary intake of AA and linoleic acid (LA).
  
  
  METHODS
  We conducted a case-cohort study nested within the Danish prospective Diet, Cancer and Health (DCH) study. After appropriate exclusions, the study included 2134 incident MI cases. Gluteal adipose tissue biopsies were collected at recruitment, and the fatty acid composition was determined by gas chromatography. A weighted Cox proportional hazards model was used to evaluate the association between adipose tissue AA content and the risk of MI.
  
  
  RESULTS
  After adjusting for confounders we found a positive association between adipose tissue AA content and the risk of MI. Hazard ratios (HR) of MI relative to the lowest quintile of adipose tissue AA content, increased across quintiles; second quintile (HR 1.19 95%CI: 0.97-1.45), third (HR 1.24 95%CI: 1.02-1.52), fourth (HR 1.28 95%CI: 1.03-1.60), and fifth quintile (HR 1.39 95%CI: 1.10-1.77). Adipose tissue AA levels were not correlated with dietary intake of AA (r=0.03, 95%CI: -0.01, 0.06) and weakly negatively correlated with dietary intake of LA (r=-0.12, 95%CI: -0.15, -0.08).
  
  
  CONCLUSIONS
  The adipose tissue content of AA was positively associated with the risk of MI but did not correlate with dietary intake of neither AA nor LA.
authors: Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Soendre Skovvej 15, 9000 Aalborg, Denmark. mrsn@rn.dk
authors: Michael Skjelbo
authors: MS
authors: Nielsen
authors: Erik Berg
authors: EB
authors: Schmidt
authors: Jakob
authors: J
authors: Stegger
authors: Anders
authors: A
authors: Gorst-Rasmussen
authors: Anne
authors: A
authors: Tjonneland
authors: Kim
authors: K
authors: Overvad
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D016718:Arachidonic Acid / Q000378:metabolism*; D003718:Denmark / Q000453:epidemiology; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000378:metabolism*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D005227:Fatty Acids; D016718:Arachidonic Acid