title: The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse.
abstract: The nuclear lamina is the structural scaffold of the nuclear envelope and is well known for its central role in nuclear organization and maintaining nuclear stability and shape. In the past, a number of severe human disorders have been identified to be associated with mutations in lamins. Extensive research on this topic has provided novel important clues about nuclear lamina function. These studies have contributed to the knowledge that the lamina constitutes a complex multifunctional platform combining both structural and regulatory functions. Here, we report that, in addition to the previously demonstrated significance for somatic cell differentiation and maintenance, the nuclear lamina is also an essential determinant for germ cell development. Both male and female mice lacking the short meiosis-specific A-type lamin C2 have a severely defective meiosis, which at least in the male results in infertility. Detailed analysis revealed that lamin C2 is required for telomere-driven dynamic repositioning of meiotic chromosomes. Loss of lamin C2 affects precise synapsis of the homologs and interferes with meiotic double-strand break repair. Taken together, our data explain how the nuclear lamina contributes to meiotic chromosome behaviour and accurate genome haploidization on a mechanistic level.
authors: Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
authors: Jana
authors: J
authors: Link
authors: Daniel
authors: D
authors: Jahn
authors: Johannes
authors: J
authors: Schmitt
authors: Eva
authors: E
authors: Göb
authors: Johannes
authors: J
authors: Baar
authors: Sagrario
authors: S
authors: Ortega
authors: Ricardo
authors: R
authors: Benavente
authors: Manfred
authors: M
authors: Alsheimer
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002875:Chromosomes / Q000235:genetics; D005260:Female; D005854:Germ Cells / Q000254:growth & development / Q000378:metabolism; D059765:Homologous Recombination / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D007797:Laminin / Q000235:genetics / Q000378:metabolism; D008297:Male; D008540:Meiosis / Q000235:genetics*; D051379:Mice; D009154:Mutation; D034881:Nuclear Lamina / Q000235:genetics / Q000378:metabolism; D034882:Lamins
chemical_list: D007797:Laminin; C087355:lamin C2; D034882:Lamins
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