title: Blood monocyte chemotactic protein-1 (MCP-1) and adapted disease activity Score28-MCP-1: favorable indicators for rheumatoid arthritis activity.
abstract: OBJECTIVE
  We assessed blood pentraxin 3 (PTX3) and macrophage chemotactic factor-1 (MCP-1) levels as indicators of disease activity in rheumatoid arthritis (RA) patients, because data on disease activity score 28 (DAS28)-erythrocyte sedimentation rate (ESR) and DAS28-C-reactive protein (CRP) are still imperfect.
  
  
  METHODS
  In 111 patients with RA, we examined longitudinal and cross-sectional correlations of blood PTX3, MCP-1, CRP, and ESR levels with measures of clinical arthritic activity, namely, swollen joint count (SJC), tender joint count (TJC), visual analog scale for general health (GH), DAS28, and adapted DAS28-MCP-1.
  
  
  RESULTS
  Blood MCP-1, but not PTX3, was significantly correlated with SJC, TJC, DAS28, and DAS28-CRP. DAS28-MCP-1 was strongly correlated with DAS28 (r  = 0.984, P<0.001) and DAS28-CRP (r  = 0.971, P<0.001), and modestly correlated with CRP (r  = 0.350, P<0.001), and ESR (r  = 0.386, P<0.001). Similarly, the duration of arthritic symptoms, but not sex, was significantly correlated with variables of arthritic activity. In particular, DAS28-MCP-1 significantly correlated with DAS28 during a 6-month period (r  = 0.944, P<0.001; r  = 0.951, P<0.001; r  = 0.862, P<0.001; and r  = 0.865, P<0.001 for month 0, 1, 3, and 6, respectively).
  
  
  CONCLUSIONS
  Blood MCP-1 and adapted DAS28-MCP-1, but not blood PTX3, may be useful in monitoring RA activity.
authors: Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Lin-kou, Kwei-san Hsiang, Tao-yuan County, Taiwan. b890121@cgmh.org.tw
authors: Lieh-bang
authors: LB
authors: Liou
authors: Wen-pin
authors: WP
authors: Tsai
authors: Chee J
authors: CJ
authors: Chang
authors: Wan-ju
authors: WJ
authors: Chao
authors: Meng-hsin
authors: MH
authors: Chen
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D015415:Biomarkers / Q000097:blood*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D018932:Chemokine CCL2 / Q000097:blood*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006801:Humans; D008137:Longitudinal Studies; D000683:Serum Amyloid P-Component / Q000032:analysis*; D012720:Severity of Illness Index; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D018932:Chemokine CCL2; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
references: J Rheumatol. 2004 Jun;31(6):1095-7
references: 15170920
references: Ann Rheum Dis. 2010 Sep;69(9):1704-10
references: 20439287
references: Blood. 2006 Jan 1;107(1):151-8
references: 16166594
references: Crit Care Med. 2008 Aug;36(8):2302-8
references: 18596636
references: Clin Rheumatol. 2008 Feb;27(2):231-5
references: 18064397
references: J Rheumatol. 2001 Jan;28(1):41-6
references: 11196541
references: Rheumatology (Oxford). 2008 Apr;47(4):514-8
references: 18321947
references: J Rheumatol. 2009 Aug;36(8):1606-10
references: 19531760
references: J Biol Chem. 1992 Nov 5;267(31):22190-7
references: 1429570
references: Exp Biol Med (Maywood). 2008 Sep;233(9):1171-80
references: 18535166
references: J Clin Immunol. 2005 Nov;25(6):582-91
references: 16380821
references: Rheumatology (Oxford). 2007 Mar;46(3):539-44
references: 17043051
references: Arthritis Care Res (Hoboken). 2010 Jan 15;62(1):108-17
references: 20191498
references: Arthritis Rheum. 2009 May;60(5):1242-9
references: 19404938
references: J Rheumatol. 2009 Aug;36(8):1568-9
references: 19671807
references: Crit Care Med. 2001 Jul;29(7):1404-7
references: 11445697
references: Mol Med Today. 1996 May;2(5):198-204
references: 8796888
references: J Exp Med. 1997 Jul 7;186(1):131-7
references: 9207007
references: Ann Rheum Dis. 2005 Sep;64(9):1294-8
references: 15829574
references: Ann Rheum Dis. 2007 Sep;66(9):1221-6
references: 17369281
references: Rheumatology (Oxford). 2010 Aug;49(8):1521-9
references: 20435650
references: Clin Exp Rheumatol. 2003 Jul-Aug;21(4):437-44
references: 12942694
references: BMC Musculoskelet Disord. 2010 Aug 23;11:187
references: 20731815
references: Arthritis Rheum. 2004 May;50(5):1400-11
references: 15146409
references: Kobe J Med Sci. 2010 Sep 30;56(3):E98-107
references: 21063156
references: Semin Arthritis Rheum. 2009 Aug;39(1):38-54
references: 18614204
references: Arthritis Res Ther. 2005;7(4):R796-806
references: 15987481
references: Arterioscler Thromb Vasc Biol. 2008 May;28(5):925-31
references: 18218986
references: Circulation. 2004 Oct 19;110(16):2349-54
references: 15477419
references: J Thorac Cardiovasc Surg. 2005 Aug;130(2):346-50
references: 16077397
references: J Exp Med. 2007 Apr 16;204(4):793-804
references: 17389238
references: Arthritis Rheum. 2006 Aug;54(8):2387-92
references: 16869001
references: Clin Exp Rheumatol. 2008 Sep-Oct;26(5):814-9
references: 19032813
references: Scand J Rheumatol. 2011 Mar;40(2):81-7
references: 20919947
references: Ann Rheum Dis. 2009 Jun;68(6):954-60
references: 18490431
references: Ann Rheum Dis. 2002 Apr;61(4):311-8
references: 11874832
references: Arthritis Rheum. 2006 Mar;54(3):986-91
references: 16508993
references: J Rheumatol. 2004 May;31(5):884-95
references: 15124246
references: Clin Exp Rheumatol. 2009 Sep-Oct;27(5):773-8
references: 19917159
references: J Rheumatol. 1997 Aug;24(8):1477-85
references: 9263138
references: Arthritis Rheum. 2003 Jun;48(6):1493-9
references: 12794815
references: J Immunol. 1993 Mar 1;150(5):1804-12
references: 7679696
references: Clin Exp Rheumatol. 2004 Jan-Feb;22(3 Suppl 33):S66-72
references: 15344601
references: Clin Rheumatol. 2008 Apr;27(4):463-7
references: 17876647
references: Ann Rheum Dis. 2007 Mar;66(3):407-9
references: 16926186
references: Rheum Dis Clin North Am. 2009 Nov;35(4):731-4, vi-vii
references: 19962617
references: Clin Exp Immunol. 2000 Jan;119(1):196-202
references: 10606983
references: Clin Chem Lab Med. 2009;47(4):471-7
references: 19327124
references: Blood. 1994 Nov 15;84(10):3483-93
references: 7949102
references: J Rheumatol. 2005 Sep;32(9):1666-72
references: 16142858
references: J Clin Immunol. 2008 Jan;28(1):1-13
references: 17828584
references: Circulation. 2009 Aug 25;120(8):699-708
references: 19667236
references: Clin Exp Rheumatol. 2004 Sep-Oct;22(5):597-602
references: 15485013
references: Arthritis Rheum. 1995 Jan;38(1):44-8
references: 7818570
references: Arthritis Rheum. 2004 Aug;50(8):2667-74
references: 15334483
references: Ann Rheum Dis. 2005 Mar;64(3):506-7
references: 15708909
references: Hum Immunol. 2000 Mar;61(3):303-8
references: 10689120
references: Int J Mol Med. 2006 Sep;18(3):415-23
references: 16865225
references: Arthritis Rheum. 2012 Mar;64(3):854-65
references: 21989653
references: Scand J Rheumatol. 2011 May;40(3):232-3
references: 21108544