title: The effects of weight loss on relative bone mineral density in premenopausal women.
abstract: OBJECTIVE
  This study compared BMD relative to body weight following a ∼6-month weight loss program and a 1-year weight maintenance phase in premenopausal women and determined whether African American (AA) and European-American (EA) women's BMD respond similarly during weight loss.
  
  
  METHODS
  Premenopausal women (n = 115, 34 ± 5 years) were evaluated in an overweight state (BMI between 27 and 30 kg/m(2) ), following an 800 kcal/day diet/exercise program designed to reduce BMI<25 kg/m(2) , and 1-year following weight loss.
  
  
  RESULTS
  BMD relative to body weight (Z-scores) increased after weight loss, but decreased during the 1-year weight maintenance phase. All 1-year follow-up BMD Z-scores were increased (except L1) compared to baseline measurements (P < 0.05). These sites included the hip neck (+0.088, P = 0.014), total hip (+0.099, P = 0.001), L2 (+0.127, P = 0.013), L3 (+0.135, P = 0.014), and L4 (+0.199, P = 0.002). AAs had significantly higher absolute BMD at all sites (P < 0.05) compared to EAs, but no time by race interactions were evident during weight loss (except in L3).
  
  
  CONCLUSIONS
  These results may indicate that weight loss is safe with regard to bone health for overweight premenopausal women.
authors: Department of Human Studies, University of Alabama-Birmingham, Birmingham, AL, USA. khamilton1@crimson.ua.edu
authors: Kara C
authors: KC
authors: Hamilton
authors: Gordon
authors: G
authors: Fisher
authors: Jane L
authors: JL
authors: Roy
authors: Barbara A
authors: BA
authors: Gower
authors: Gary R
authors: GR
authors: Hunter
mesh_terms: D000328:Adult; D001741:Black or African American; D001823:Body Composition; D015992:Body Mass Index; D015519:Bone Density; D004032:Diet; D015444:Exercise; D005260:Female; D006615:Hip; D006801:Humans; D008875:Middle Aged; D050177:Overweight / Q000628:therapy; D017697:Premenopause; D015431:Weight Loss; D044465:White People; D055815:Young Adult
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