title: Comparative study of the complex forming ability and enantioselectivity of cyclodextrin polymers by CE and 1H NMR.
abstract: The interactions between nine drugs (baclofen, bupivacaine, chlorpheniramine, ketoconazole, paliperidone, promethazine, propranolol, risperidone and verapamil) and six cyclodextrins (α-CD, β-CD, γ-CD, HP-β-CD, HP-γ-CD and Me-β-CD) or six polymers of cyclodextrins (polyα-CD, polyβ-CD, polyγ-CD, polyHP-β-CD, polyHP-γ-CD and polyMe-β-CD) were studied by affinity capillary electrophoresis and/or (1)H NMR at pH 2.5. An exhaustive qualitative study was performed through the determination of the retardation factor. Then, four compounds and both β-CD and polyβ-CD were selected for the quantitative study of the interactions at pH 2.5 and 7.0. By comparing the results obtained with the β-CD and polyβ-CD, it appears that the apparent binding constants are up to five times higher with the polymer. The 2D-NMR results seem to indicate that the structure of the polymeric network favours the inclusion of the guest in the hydrophobic cavity of the CD units. Moreover, the poly-CDs have shown very high enantioselective abilities at both pH.
authors: Univ Lille Nord de France, F-59000 Lille, France. cecile.danel@univ-lille2.fr
authors: Cécile
authors: C
authors: Danel
authors: Nathalie
authors: N
authors: Azaroual
authors: Cédric
authors: C
authors: Chavaria
authors: Pascal
authors: P
authors: Odou
authors: Bernard
authors: B
authors: Martel
authors: Claude
authors: C
authors: Vaccher
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary; D009682:Magnetic Resonance Spectroscopy; D018967:Risperidone / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D003505:Cyclodextrins; D018967:Risperidone