title: In vivo quantification of clot formation in extracorporeal circuits.
abstract: Clot formation is a common complication in extracorporeal circuits. In this paper we describe a novel method for clot formation analysis using image processing. We assembled a closed extracorporeal circuit and circulated blood at varying speeds. Blood filters were placed in downstream of the flow, and clotting agents were added to the circuit. Digital images of the filter were subsequently taken, and image analysis was applied to calculate the density of the clot. Our results show a significant correlation between the cumulative size of the clots, the density measure of the clot based on image analysis, and flow duration in the system.
authors: Department of Surgery, Oregon Health and Science University, Portland, OR, USA. gerrah@ohsu.edu
authors: Rabin
authors: R
authors: Gerrah
authors: Omid
authors: O
authors: David
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D004867:Equipment Design; D005112:Extracorporeal Circulation / Q000295:instrumentation* / Q000379:methods; D006440:Hemofiltration / Q000295:instrumentation*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D018715:Microscopy, Video / Q000295:instrumentation* / Q000379:methods*; D012212:Rheology / Q000295:instrumentation* / Q000379:methods*