title: Interspecies extrapolation based on the RepDose database--a probabilistic approach.
abstract: Repeated dose toxicity studies from the RepDose database (DB) were used to determine interspecies differences for rats and mice. NOEL (no observed effect level) ratios based on systemic effects were investigated for three different types of exposure: inhalation, oral food/drinking water and oral gavage. Furthermore, NOEL ratios for local effects in inhalation studies were evaluated. On the basis of the NOEL ratio distributions, interspecies assessment factors (AF) are evaluated. All data sets were best described by a lognormal distribution. No difference was seen between inhalation and oral exposure for systemic effects. Rats and mice were on average equally sensitive at equipotent doses with geometric mean (GM) values of 1 and geometric standard deviation (GSD) values ranging from 2.30 to 3.08. The local AF based on inhalation exposure resulted in a similar distribution with GM values of 1 and GSD values between 2.53 and 2.70. Our analysis confirms former analyses on interspecies differences, including also dog and human data. Furthermore it supports the principle of allometric scaling according to caloric demand in the case that body doses are applied. In conclusion, an interspecies distribution animal/human with a GM equal to allometric scaling and a GSD of 2.5 was derived.
authors: Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai Fuchs Str. 1, 30625 Hannover, Germany. Sylvia.Escher@item.fraunhofer.de
authors: Sylvia E
authors: SE
authors: Escher
authors: Monika
authors: M
authors: Batke
authors: Simone
authors: S
authors: Hoffmann-Doerr
authors: Horst
authors: H
authors: Messinger
authors: Inge
authors: I
authors: Mangelsdorf
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D016208:Databases, Factual; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006801:Humans; D019570:Inhalation Exposure; D051379:Mice; D015233:Models, Statistical; D019055:No-Observed-Adverse-Effect Level; D051381:Rats; D018570:Risk Assessment; D013045:Species Specificity