title: Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease.
abstract: Early-onset Alzheimer's disease (EOAD) has been shown to progress more rapidly than late-onset Alzheimer's disease (LOAD). However, no studies have compared the topography of brain volume reduction over time. The purpose of this 3-year longitudinal study was to compare EOAD and LOAD in terms of their rates of decline in cognitive testing and topography of cortical thinning. We prospectively recruited 36 patients with AD (14 EOAD and 22 LOAD) and 14 normal controls. All subjects were assessed with neuropsychological tests and with magnetic resonance imaging at baseline, Year 1, and Year 3. The EOAD group showed more rapid decline than the LOAD group in attention, language, and frontal-executive tests. The EOAD group also showed more rapid cortical thinning in widespread association cortices. In contrast, the LOAD group presented more rapid cortical thinning than the EOAD group only in the left parahippocampal gyrus. Our study suggests that patients with EOAD show more rapid cortical atrophy than patients with LOAD, which accounts for faster cognitive decline on neuropsychological tests.
authors: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Hanna
authors: H
authors: Cho
authors: Seun
authors: S
authors: Jeon
authors: Sue J
authors: SJ
authors: Kang
authors: Jong-Min
authors: JM
authors: Lee
authors: Jae-Hong
authors: JH
authors: Lee
authors: Geon Ha
authors: GH
authors: Kim
authors: Ji Soo
authors: JS
authors: Shin
authors: Chi Hun
authors: CH
authors: Kim
authors: Young
authors: Y
authors: Noh
authors: Kiho
authors: K
authors: Im
authors: Sung Tae
authors: ST
authors: Kim
authors: Juhee
authors: J
authors: Chin
authors: Sang Won
authors: SW
authors: Seo
authors: Duk L
authors: DL
authors: Na
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000473:pathology*; D001284:Atrophy / Q000453:epidemiology / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies