title: Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination.
abstract: The introduction of new rapid diagnostic tools for tuberculosis (TB) and the promising TB drugs pipeline together with the development of a new World Health Organization Strategy post 2015 allows new discussions on how to direct TB control. The European Respiratory Society's European Forum for TB Innovation was created to stimulate discussion on how to best take advantage of old and new opportunities, and advances, to improve TB control and eventually progress towards the elimination of TB. While TB control is aimed at reducing the incidence of TB by early diagnosis and treatment of infectious cases of TB, TB elimination requires focus on sterilising the pool of latently infected individuals, from which future TB cases would be generated. This manuscript describes the three core components that are necessary to implement the elimination strategy fully. 1) Improve diagnosis of latent TB infected individuals. 2) Improve regimens to treat latent TB infection. 3) ensure public health commitment to make both 1) and 2) possible. Old and new evidence is critically described, focusing on the European commitment to reach elimination and on the innovative experiences and best practices available.
authors: University Medical Hospital Schleswig-Holstein, Member of the German Center for Lung Research, DZL, Kiel.
authors: Roland
authors: R
authors: Diel
authors: Robert
authors: R
authors: Loddenkemper
authors: Jean-Pierre
authors: JP
authors: Zellweger
authors: Giovanni
authors: G
authors: Sotgiu
authors: Lia
authors: L
authors: D'Ambrosio
authors: Rosella
authors: R
authors: Centis
authors: Marieke J
authors: MJ
authors: van der Werf
authors: Masoud
authors: M
authors: Dara
authors: Anne
authors: A
authors: Detjen
authors: Peter
authors: P
authors: Gondrie
authors: Lee
authors: L
authors: Reichman
authors: Francesco
authors: F
authors: Blasi
authors: Giovanni Battista
authors: GB
authors: Migliori
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D003140:Communicable Disease Control / Q000379:methods; D060740:Disease Eradication / Q000379:methods; D006801:Humans; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control*
chemical_list: D000995:Antitubercular Agents