title: The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi.
abstract: Protein egress from the endoplasmic reticulum (ER) is driven by a conserved cytoplasmic coat complex called the COPII coat. The COPII coat complex contains an inner shell (Sec23/Sec24) that sorts cargo into ER-derived vesicles and an outer cage (Sec13/Sec31) that leads to coat polymerization. Once released from the ER, vesicles must tether to and fuse with the target membrane to deliver their protein and lipid contents. This delivery step also depends on the COPII coat, with coat proteins binding directly to tethering and regulatory factors. Recent findings have yielded new insight into how COPII-mediated vesicle traffic is regulated. Here we discuss the molecular basis of COPII-mediated ER-Golgi traffic, focusing on the surprising complexity of how ER-derived vesicles form, package diverse cargoes, and correctly target these cargoes to their destination.
authors: Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093, USA.
authors: Christopher
authors: C
authors: Lord
authors: Susan
authors: S
authors: Ferro-Novick
authors: Elizabeth A
authors: EA
authors: Miller
mesh_terms: D001692:Biological Transport / Q000502:physiology; D022181:COP-Coated Vesicles / Q000378:metabolism / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D008561:Membrane Fusion; D008954:Models, Biological; D021382:Protein Sorting Signals; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: D021382:Protein Sorting Signals; D033921:Vesicular Transport Proteins
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