title: Pericentric inversion of chromosom 12 [Inv (12) (p12q12)] associated with idiopathic azoospermia in one infertile Tunisian man.
abstract: Chromosome aberrations are found in 2-7% of couples with fertility problems and pericentric inversions are structural chromosomal abnormalities, potentially associated with infertility or multiple miscarriages. In this study, we report the first case of pericentric inversion of chromosome 12 associated with non-obstructive azoospermia. A karyogram revealed pericentric inversion of chromosome 12 with breakpoints at 12p12 and 12q12. Testicular histopathology confirmed the Sertoli cell-only syndrome.
authors: Laboratory of Human Molecular Genetics, Faculty of Medicine, Sfax, Tunisia. myriamgh29@gmail.com
authors: Myriam
authors: M
authors: Ghorbel
authors: Siwar
authors: S
authors: Baklouti-Gargouri
authors: Hatem
authors: H
authors: ElGhazel
authors: Nacira
authors: N
authors: Zribi
authors: Fatma
authors: F
authors: Ben Abdallah
authors: Meriem
authors: M
authors: Cherif
authors: Faiza
authors: F
authors: Fakhfakh
authors: Ali
authors: A
authors: Saad
authors: Leila
authors: L
authors: Ammar-Keskes
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000235:genetics* / Q000473:pathology; D007446:Chromosome Inversion; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D006801:Humans; D059785:Karyotype; D008297:Male; D054331:Sertoli Cell-Only Syndrome / Q000235:genetics* / Q000473:pathology; D013737:Testis / Q000473:pathology; D014416:Tunisia