title: Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms.
abstract: Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.
authors: Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, United States.
authors: Xiaofeng
authors: X
authors: Chen
authors: Hong
authors: H
authors: Lu
authors: Debra L
authors: DL
authors: Rateri
authors: Lisa A
authors: LA
authors: Cassis
authors: Alan
authors: A
authors: Daugherty
mesh_terms: D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001014:Aortic Aneurysm / Q000378:metabolism*; D006801:Humans; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta; D000804:Angiotensin II
references: Hum Mol Genet. 2010 Dec 15;19(24):4790-8
references: 20871099
references: Science. 2011 Apr 15;332(6027):358-61
references: 21493862
references: Am J Physiol Cell Physiol. 2007 Jan;292(1):C82-97
references: 16870827
references: Cardiovasc Res. 2011 Feb 1;89(2):446-56
references: 20829218
references: Nature. 2011 May 19;473(7347):308-16
references: 21593863
references: Circulation. 2009 Jan 27;119(3):426-35
references: 19139386
references: Arterioscler Thromb Vasc Biol. 2001 Jul;21(7):1184-9
references: 11451749
references: Science. 2011 Apr 15;332(6027):361-5
references: 21493863
references: Circ Res. 2006 Apr 28;98(8):1032-9
references: 16556868
references: PLoS One. 2011;6(8):e23411
references: 21858106
references: Circ Res. 2012 Jan 20;110(2):312-24
references: 22116819
references: Science. 2006 Apr 7;312(5770):117-21
references: 16601194
references: Circ Res. 2012 Jun 8;110(12):e92-e101
references: 22550139
references: Am J Pathol. 2011 Sep;179(3):1542-8
references: 21763672
references: Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):e1-11
references: 21979435
references: Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1712-20
references: 16675726
references: Pharmacol Ther. 2011 Jul;131(1):50-60
references: 21504760
references: Transgenic Res. 2010 Dec;19(6):1069-82
references: 20213136
references: Nat Rev Mol Cell Biol. 2007 Dec;8(12):970-82
references: 18000526
references: Physiol Genomics. 2011 Sep 8;43(17):993-1003
references: 21712436
references: Clin Sci (Lond). 2012 Nov;123(9):531-43
references: 22788237
references: Circ Res. 2002 Apr 19;90(7):754-6
references: 11964366
references: Arterioscler Thromb Vasc Biol. 1997 Jul;17(7):1251-7
references: 9261254
references: J Am Coll Cardiol. 2011 Dec 6;58(24):2522-30
references: 22133853
references: J Clin Invest. 2010 Feb;120(2):422-32
references: 20101093
references: Clin Sci (Lond). 2010 Mar 09;118(11):681-9
references: 20088827
references: Circulation. 2005 May 17;111(19):2509-17
references: 15883213
references: Br J Pharmacol. 2012 Mar;165(6):2000-2008
references: 22014125
references: Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):397-405
references: 22095985
references: Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):1015-23
references: 22282354
references: J Clin Invest. 2002 Mar;109(6):787-96
references: 11901187
references: J Renin Angiotensin Aldosterone Syst. 2000 Dec;1(4):342-52
references: 11967821
references: J Thorac Cardiovasc Surg. 2010 Aug;140(2):305-312.e2
references: 20189193
references: N Engl J Med. 2008 Jun 26;358(26):2787-95
references: 18579813
references: Circ Res. 2011 Mar 4;108(5):574-81
references: 21252156