title: Disinfection of needleless connectors with chlorhexidine-alcohol provides long-lasting residual disinfectant activity.
abstract: The optimal disinfection method for needleless connectors (NCs) is unclear. We used an experimental model of microbial NC contamination to test different scrub times (swipe, 5, 15, 30 seconds) of chlorhexidine-alcohol versus alcohol and for residual disinfectant activity. Swipe with alcohol did not adequately disinfect NCs, particularly when contaminated with Staphylococcus aureus or Pseudomonas aeruginosa. With ≥5-second scrub, chlorhexidine-alcohol and alcohol performed similarly, but chlorhexidine-alcohol showed residual disinfectant activity for up to 24 hours.
authors: Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors: Haeyeon
authors: H
authors: Hong
authors: Debra Forbes
authors: DF
authors: Morrow
authors: Thomas J
authors: TJ
authors: Sandora
authors: Gregory P
authors: GP
authors: Priebe
mesh_terms: D019840:2-Propanol / Q000008:administration & dosage* / Q000494:pharmacology; D002408:Catheters, Indwelling / Q000382:microbiology*; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000494:pharmacology; D003428:Cross Infection / Q000517:prevention & control; D004202:Disinfectants / Q000008:administration & dosage* / Q000494:pharmacology; D004203:Disinfection / Q000379:methods*; D004866:Equipment Contamination / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D004202:Disinfectants; D019840:2-Propanol; D002710:Chlorhexidine
keywords: Central line-associated bloodstream infection; Line maintenance bundle