title: Lysophosphatidylcholine, oxidized low-density lipoprotein and cardiovascular disease in Korean hemodialysis patients: analysis at 5 years of follow-up.
abstract: Although oxidized low-density lipoprotein (LDL) and lysophosphatidylcholine (LPC) have been proposed as important mediators of the atherosclerosis, the long-term contribution to the risk of cardiovascular disease (CVD) in hemodialysis patients has not been evaluated. This study investigated the relation between oxidized LDL and LPC levels with long term risk of CVD. Plasma oxidized LDL and LPC levels were determined in 69 Korean hemodialysis patients as a prospective observational study for 5 yr. During the observation period, 18 cardiovascular events (26.1%) occurred including 6 deaths among the hemodialysis patients. The low LPC level group (≤ 254 µM/L, median value) had much more increased risk of CVD compared to the high LPC level group (> 254 µM/L) (P = 0.01). However, serum levels of oxidized LDL were not significantly different between groups with and without CVD. In adjusted Cox analysis, previous CVD, (hazard ratio [HR], 5.68; 95% confidence interval [CI], 1.94-16.63, P = 0.002) and low LPC level (HR, 3.45; 95% CI, 1.04-11.42, P = 0.04) were significant independent risk factors for development of CVD. It is suggested that low LPC, but not oxidized LDL, is associated with increased risk of CVD among a group of Korean hemodialysis patients.
authors: Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea.
authors: Young-Ki
authors: YK
authors: Lee
authors: Dong Hun
authors: DH
authors: Lee
authors: Jin Kyung
authors: JK
authors: Kim
authors: Min-Jeong
authors: MJ
authors: Park
authors: Ji-Jing
authors: JJ
authors: Yan
authors: Dong-Keun
authors: DK
authors: Song
authors: Nosratola D
authors: ND
authors: Vaziri
authors: Jung-Woo
authors: JW
authors: Noh
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis; D008077:Lipoproteins, LDL / Q000097:blood*; D008244:Lysophosphatidylcholines / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D006435:Renal Dialysis; D056910:Republic of Korea; D012307:Risk Factors
chemical_list: D008077:Lipoproteins, LDL; D008244:Lysophosphatidylcholines; C099252:oxidized low density lipoprotein
keywords: Cardiovascular Disease; Lipoproteins; Lysophosphatidylcholines; Oxidized LDL; Renal Dialysis
references: Curr Med Chem. 2007;14(30):3209-20
references: 18220755
references: Clin Biochem. 2002 Jul;35(5):411-6
references: 12270773
references: Nat Rev Nephrol. 2010 May;6(5):287-96
references: 20308998
references: N Engl J Med. 2005 Jul 7;353(1):46-57
references: 16000355
references: Ann Saudi Med. 2001 Sep-Nov;21(5-6):283-6
references: 17261929
references: Nat Med. 2004 Feb;10(2):161-7
references: 14716308
references: Atherosclerosis. 2010 Jan;208(1):10-8
references: 19570538
references: Nephrol Dial Transplant. 2007 Feb;22(2):515-21
references: 17050638
references: J Nutr Sci Vitaminol (Tokyo). 1998 Dec;44(6):809-18
references: 10197312
references: Clin Nephrol. 2008 Aug;70(2):135-43
references: 18793529
references: J Immunol. 2005 Mar 1;174(5):2981-9
references: 15728511
references: N Engl J Med. 1989 Apr 6;320(14):915-24
references: 2648148
references: Am J Physiol Renal Physiol. 2006 Feb;290(2):F262-72
references: 16403839
references: Kidney Int. 1999 Mar;55(3):1005-10
references: 10027937
references: Kidney Int. 1994 Mar;45(3):876-83
references: 8196291
references: J Lipid Res. 2003 Apr;44(4):754-61
references: 12562829
references: Lipids. 2008 Mar;43(3):243-9
references: 18256867
references: J Biol Chem. 1999 Sep 3;274(36):25189-92
references: 10464236
references: Nephrol Dial Transplant. 2006 Apr;21(4):984-90
references: 16326744
references: Kidney Int. 2003 Mar;63(3):793-808
references: 12631061
references: Kidney Int. 2002 May;61(5):1887-93
references: 11967041
references: Circulation. 2003 Dec 23;108(25):3128-33
references: 14638540