title: Therapeutic potential of neuregulin-1 in cardiovascular disease.
abstract: Neuregulin-1 (NRG-1)/ErbB signaling has an indispensable role in cardiac development and in the maintenance of the structural and functional integrity of the human adult heart in health and disease. Several animal studies have now demonstrated the therapeutic effects of NRG-1 during acute cardiac injury and during chronic heart failure, with improvements in cardiac performance and animal survival. Phase I and II clinical trials for chronic heart failure in humans are now in progress.
authors: Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
authors: Pedro
authors: P
authors: Mendes-Ferreira
authors: Gilles W
authors: GW
authors: De Keulenaer
authors: Adelino F
authors: AF
authors: Leite-Moreira
authors: Carmen
authors: C
authors: Brás-Silva
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D066246:ErbB Receptors / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D020890:Neuregulin-1 / Q000378:metabolism / Q000627:therapeutic use*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000187:drug effects / Q000378:metabolism; D066247:Receptor, ErbB-4; D011994:Recombinant Proteins / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D002317:Cardiovascular Agents; D066246:ErbB Receptors; D020890:Neuregulin-1; D018719:Erb-b2 Receptor Tyrosine Kinases; D066247:Receptor, ErbB-4; D011994:Recombinant Proteins; C587689:ERBB4 protein, human