title: Capparis ovata modulates brain oxidative toxicity and epileptic seizures in pentylentetrazol-induced epileptic rats.
abstract: It has been widely suggested that oxidative stress products play an important role in the pathophysiology of epilepsy. Capparis ovata (C. ovata) may useful treatment of epilepsy because it contains antioxidant flavonoids. The current study was designed to determine the effects of C. ovata on lipid peroxidation, antioxidant levels and electroencephalography (EEG) records in pentylentetrazol (PTZ)-induced epileptic rats. Thirty-two rats were randomly divided into four groups. First group was used as control although second group was PTZ group. Oral 100 and 200 mg/kg C. ovata were given to rats constituting the third and fourth groups for 7 days before PTZ administration. Second, third and forth groups received 60 mg/kg PTZ for induction of epilepsy. Three hours after administration of PTZ, EEG records, brain cortex and blood samples were taken all groups. The lipid peroxidation levels of the brain cortex, number of spikes and epileptiform discharges of EEG were higher in PTZ group than in control and C. ovata group whereas they were decreased by C. ovata administration. Vitamin A, vitamin C, vitamin E and β-carotene concentrations of brain cortex and latency to first spike of EEG were decreased by the PTZ administration although the brain cortex and plasma vitamin concentrations, and brain cortex and erythrocyte glutathione and glutathione peroxidase values were increased in PTZ + 100 and PTZ + 200 mg C. ovata groups. In conclusion, C. ovata administration caused protection against the PTZ-induced brain oxidative toxicity by inhibiting free radical and epileptic seizures, and supporting antioxidant redox system.
authors: Neuroscience Research Center, Medical Faculty, Suleyman Demirel University, Tıp Fakultesi Dekanlik Binasi, 32260 Isparta, Turkey. mustafanaziroglu@sdu.edu.tr
authors: Mustafa
authors: M
authors: Nazıroğlu
authors: Mehmet Berk
authors: MB
authors: Akay
authors: Ömer
authors: Ö
authors: Çelik
authors: Muhammed İkbal
authors: Mİ
authors: Yıldırım
authors: Erdinç
authors: E
authors: Balcı
authors: Vedat Ali
authors: VA
authors: Yürekli
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D031484:Capparis / Q000737:chemistry*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D010433:Pentylenetetrazole; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014801:Vitamin A / Q000378:metabolism; D014810:Vitamin E / Q000097:blood; D019207:beta Carotene / Q000378:metabolism
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D005979:Glutathione Peroxidase; D010433:Pentylenetetrazole
references: Anal Biochem. 1966 Aug;16(2):359-64
references: 6007581
references: Phytother Res. 2010 Jan;24 Suppl 1:S6-S10
references: 19548287
references: Acta Neurol Scand. 2002 Nov;106(5):258-62
references: 12371918
references: Neuropharmacology. 2005 Sep;49(4):456-64
references: 15913671
references: Neurochem Res. 2007 Nov;32(11):1990-2001
references: 17562166
references: Neurochem Res. 2011 Nov;36(11):2195-204
references: 21751034
references: J Agric Food Chem. 2011 Dec 14;59(23):12453-9
references: 22017607
references: Pharm Biol. 2013 Jan;51(1):49-57
references: 22979904
references: Biochem Biophys Res Commun. 1976 Aug 23;71(4):952-8
references: 971321
references: Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jun;26(5):995-1005
references: 12369276
references: Pharm Biol. 2010 Oct;48(10):1185-90
references: 20819022
references: J Biol Chem. 1951 Nov;193(1):265-75
references: 14907713
references: Biol Trace Elem Res. 2009 Summer;129(1-3):181-9
references: 19127351
references: Clin Chim Acta. 2008 Apr;390(1-2):1-11
references: 18243141
references: J Membr Biol. 2008 Sep-Oct;225(1-3):39-49
references: 18949505
references: J Physiol Biochem. 2011 Mar;67(1):105-13
references: 20960085
references: Pharm Biol. 2010 May;48(5):589-94
references: 20645804
references: Neurotox Res. 2012 Jan;21(1):70-8
references: 21927955
references: Methods Enzymol. 1984;105:138-47
references: 6727662
references: Epilepsy Behav. 2011 Dec;22(4):678-84
references: 22056341
references: Plant Foods Hum Nutr. 2010 Sep;65(3):260-5
references: 20668946
references: J Membr Biol. 2009 Jun;229(3):131-40
references: 19513780
references: Anal Biochem. 1982 Nov 15;127(1):178-82
references: 7165085
references: Pol J Pharmacol. 2004 Sep-Oct;56(5):553-61
references: 15591643
references: Nutr Health. 2003;17(1):71-6
references: 12803284
references: J Nat Med. 2013 Jan;67(1):152-8
references: 22484603
references: Int J Mol Sci. 2011;12(12):8846-61
references: 22272107
references: Anal Biochem. 1968 Oct 24;25(1):192-205
references: 4973948
references: Peptides. 2008 Mar;29(3):448-55
references: 18215442
references: J Recept Signal Transduct Res. 2012 Jun;32(3):134-41
references: 22475023
references: Epilepsy Behav. 2008 Jul;13(1):77-82
references: 18396108
references: J Agric Food Chem. 2005 Sep 7;53(18):7136-41
references: 16131121
references: Clin Chim Acta. 2004 Feb;340(1-2):229-33
references: 14734217
references: Brain. 2007 Dec;130(Pt 12):3155-68
references: 18055492
references: Neurochem Res. 2012 Oct;37(10):2065-75
references: 22846968
references: Neurochem Res. 2009 Dec;34(12):2181-91
references: 19513830
references: Food Sci Technol Int. 2011 Apr;17(2):87-97
references: 21436235
references: Proc Natl Acad Sci U S A. 1989 Aug;86(16):6377-81
references: 2762330
references: Fitoterapia. 2011 Mar;82(2):93-101
references: 20851750