title: Human biomarkers of rapid antidepressant effects.
abstract: Mood disorders such as major depressive disorder and bipolar disorder--and their consequent effects on the individual and society--are among the most disabling and costly of all medical illnesses. Although a number of antidepressant treatments are available in clinical practice, many patients still undergo multiple and lengthy medication trials before experiencing relief of symptoms. Therefore a tremendous need exists to improve current treatment options and to facilitate more rapid, successful treatment in patients suffering from the deleterious neurobiological effects of ongoing depression. Toward that end, ongoing research is exploring the identification of biomarkers that might be involved in prevention, diagnosis, treatment response, severity, or prognosis of depression. Biomarkers evaluating treatment response will be the focus of this review, given the importance of providing relief to patients in a more expedient and systematic manner. A novel approach to developing such biomarkers of response would incorporate interventions with a rapid onset of action--such as sleep deprivation or intravenous drugs (e.g., ketamine or scopolamine). This alternative translational model for new treatments in psychiatry would facilitate shorter studies, improve feasibility, and increase higher compound throughput testing for these devastating disorders.
authors: Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. zaratec@mail.nih.gov
authors: Carlos A
authors: CA
authors: Zarate
authors: Daniel C
authors: DC
authors: Mathews
authors: Maura L
authors: ML
authors: Furey
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D019964:Mood Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D059906:Neuroimaging; D012892:Sleep Deprivation / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D015415:Biomarkers; D018698:Glutamic Acid
references: Biol Psychiatry. 2012 Oct 1;72(7):555-61
references: 22521148
references: Psychiatry Res. 2009 Sep 30;173(3):238-42
references: 19682864
references: J Psychiatr Res. 2009 Jan;43(3):175-80
references: 18533184
references: J Affect Disord. 2009 Feb;113(1-2):183-7
references: 18533273
references: Psychiatry Res. 1997 Sep 29;75(2):67-74
references: 9351489
references: Pharmacopsychiatry. 1994 Mar;27(2):70-1
references: 8029315
references: Sleep. 2007 Dec;30(12):1617-30
references: 18246972
references: Prog Neuropsychopharmacol Biol Psychiatry. 2008 Dec 12;32(8):1863-6
references: 18801406
references: Am J Psychiatry. 1982 May;139(5):571-6
references: 7072840
references: Arch Gen Psychiatry. 2006 Jul;63(7):741-7
references: 16818863
references: J Clin Psychiatry. 2009 Dec;70(12):1662-6
references: 19744406
references: J Affect Disord. 2010 Feb;121(1-2):68-72
references: 19520435
references: Am J Psychiatry. 1999 May;156(5):683-9
references: 10327899
references: Clin Pharmacol Ther. 2001 Mar;69(3):89-95
references: 11240971
references: Am J Geriatr Psychiatry. 2002 Sep-Oct;10(5):561-7
references: 12213690
references: J Psychiatr Res. 2001 May-Jun;35(3):155-63
references: 11461711
references: Brain Res. 2000 Dec 8;885(2):303-21
references: 11102586
references: Int J Neuropsychopharmacol. 2012 Sep;15(8):1063-72
references: 22040773
references: Arch Gen Psychiatry. 2006 Aug;63(8):856-64
references: 16894061
references: J Affect Disord. 2013 Feb 15;145(1):115-9
references: 22871531
references: Curr Psychiatry Rep. 2010 Dec;12(6):553-62
references: 20963521
references: Arch Gen Psychiatry. 2010 Aug;67(8):793-802
references: 20679587
references: Am J Psychiatry. 1999 Aug;156(8):1149-58
references: 10450253
references: Neuropsychopharmacology. 2001 May;24(5):467-77
references: 11282247
references: Arch Gen Psychiatry. 2007 Feb;64(2):179-87
references: 17283285
references: Biol Psychiatry. 1994 Jun 1;35(11):880-5
references: 8054411
references: Nervenarzt. 1999 Jul;70(7):620-6
references: 10434261
references: Am J Psychiatry. 1990 Jan;147(1):14-21
references: 2403471
references: Neuropsychopharmacology. 2010 Jun;35(7):1415-22
references: 20393460
references: Prog Neuropsychopharmacol Biol Psychiatry. 2002 Oct;26(6):1167-70
references: 12452541
references: Hum Mol Genet. 2004 Sep 1;13(17):1903-11
references: 15229186
references: Pharmacopsychiatry. 2006 Jan;39(1):23-9
references: 16453251
references: Am J Psychiatry. 2004 Oct;161(10):1776-82
references: 15465973
references: Arch Gen Psychiatry. 1992 Aug;49(8):651-68; discussion 669-70
references: 1386215
references: Neuropsychopharmacology. 2011 Jan;36(1):52-73
references: 20668433
references: Drugs. 2012 Jul 9;72(10):1313-33
references: 22731961
references: Curr Opin Neurol. 2011 Aug;24(4):364-70
references: 21725241
references: Biol Psychiatry. 2000 Oct 15;48(8):766-77
references: 11063973
references: Mol Psychiatry. 2011 Apr;16(4):407-18
references: 20351719
references: Biol Psychiatry. 2012 Dec 1;72(11):e27-8
references: 22771240
references: Sleep. 2007 Dec;30(12):1643-57
references: 18246974
references: Am J Psychiatry. 1979 Nov;136(11):1424-7
references: 227281
references: Lancet. 2007 Sep 8;370(9590):851-8
references: 17826170
references: Biol Psychiatry. 2003 Oct 1;54(7):687-92
references: 14512208
references: Int J Psychiatry Med. 2007;37(3):315-29
references: 18314859
references: Arch Gen Psychiatry. 2007 Feb;64(2):193-200
references: 17283286
references: Neurochem Int. 2002 Dec;41(6):377-82
references: 12213224
references: Nervenarzt. 2010 Mar;81(3):347-54
references: 20012932
references: Am J Psychiatry. 1998 Jun;155(6):726-32
references: 9619143
references: Curr Opin Psychiatry. 2006 Jan;19(1):34-9
references: 16612176
references: Psychopharmacology (Berl). 2009 Mar;203(1):155-60
references: 18989660
references: Brain Res Bull. 2009 Sep 28;80(3):158-62
references: 19576267
references: Int J Neuropsychopharmacol. 2008 Dec;11(8):1169-80
references: 18752720
references: J Neurosci. 2005 Dec 7;25(49):11231-8
references: 16339018
references: Ann N Y Acad Sci. 2004 Dec;1032:216-23
references: 15677414
references: J Clin Psychiatry. 2007 Dec;68(12):1931-8
references: 18162025
references: Biol Psychiatry. 2009 Feb 15;65(4):289-95
references: 18822408
references: Biol Psychiatry. 2012 Jun 1;71(11):996-1005
references: 22036038
references: Depress Anxiety. 2001;14(1):37-49
references: 11568981
references: J Sleep Res. 2009 Sep;18(3):342-8
references: 19549078
references: Psychiatry Res. 1994 Jun;55(2):101-9
references: 10711798
references: J Clin Psychiatry. 2006;67 Suppl 6:3-8
references: 16848670
references: Arch Gen Psychiatry. 2008 Jul;65(7):826-38
references: 18606955
references: Biol Psychiatry. 2010 Nov 1;68(9):785-94
references: 20728076
references: Int J Neuropsychopharmacol. 2013 Mar;16(2):301-11
references: 22676966
references: Psychiatry Res. 1991 Dec;40(4):247-51
references: 1811242
references: Biol Psychiatry. 2009 Jan 15;65(2):181-4
references: 18996507
references: J Affect Disord. 2008 Apr;107(1-3):181-6
references: 18031825
references: Biol Psychiatry. 2000 Feb 15;47(4):351-4
references: 10686270
references: Am J Psychiatry. 1999 Sep;156(9):1450-2
references: 10484962
references: Arch Gen Psychiatry. 1980 Mar;37(3):267-71
references: 7189111
references: Brain Res Bull. 2011 Aug 10;86(1-2):129-33
references: 21704134
references: J Psychiatr Res. 2011 Aug;45(8):1019-26
references: 21397252
references: Neuropsychopharmacology. 2011 Jan;36(1):183-206
references: 20861828
references: Curr Pharm Des. 2009;15(22):2637-49
references: 19689334
references: Nature. 2011 Sep 28;477(7366):526-8
references: 21956311
references: Biol Psychiatry. 1980 Dec;15(6):879-89
references: 7459409
references: Expert Opin Drug Discov. 2012 Jan;7(1):63-72
references: 22468894
references: Neuropsychobiology. 2011;64(3):141-51
references: 21811084
references: Dev Neurobiol. 2010 Apr;70(5):289-97
references: 20186711
references: Pharmacol Rev. 2012 Apr;64(2):238-58
references: 22407616
references: J Affect Disord. 2007 Aug;101(1-3):195-200
references: 17250898
references: Biol Psychiatry. 2012 Jun 1;71(11):939-46
references: 22297150
references: World J Biol Psychiatry. 2003 Jul;4(3):111-4
references: 12872203
references: Biol Psychiatry. 2012 Oct 1;72(7):537-47
references: 22705040
references: Arch Gen Psychiatry. 2006 Oct;63(10):1121-9
references: 17015814
references: Lancet. 1972 Jun 3;1(7762):1236-7
references: 4113219
references: Acta Psychiatr Scand. 1992 Dec;86(6):478-83
references: 1471542
references: Neuropsychopharmacology. 2010 Nov;35(12):2479-88
references: 20736989
references: Neuropharmacology. 2012 Jan;62(1):63-77
references: 21827775
references: Cell. 2003 Jan 24;112(2):257-69
references: 12553913
references: Biol Psychiatry. 2012 Aug 15;72(4):331-8
references: 22516044
references: Neuropsychopharmacology. 2003 Apr;28(4):720-5
references: 12655317
references: Psychiatry Res. 2006 Jan 30;146(1):43-51
references: 16380239
references: JAMA Psychiatry. 2013 Mar;70(3):280-90
references: 23364679
references: Am J Psychiatry. 1992 Apr;149(4):538-43
references: 1554042
references: J Affect Disord. 2012 Feb;136(3):514-9
references: 22119086
references: Biol Psychiatry. 1996 Feb 1;39(3):171-81
references: 8837978