title: The inner blood-retinal barrier: molecular structure and transport biology.
abstract: The inner blood-retinal barrier (inner BRB) is created by complex tight junctions of retinal capillary endothelial cells. Although this barrier prevents the free diffusion of substances between the circulating blood and the neural retina, the inner BRB efficiently supplies nutrients to the retina and removes endobiotics and xenobiotics from the retina to maintain a constant milieu in the neural retina. We review herein the molecular structure and transport mechanism at the inner BRB.
authors: Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan. hosoyak@pha.u-toyama.ac.jp
authors: Ken-ichi
authors: K
authors: Hosoya
authors: Masanori
authors: M
authors: Tachikawa
mesh_terms: D022005:Adherens Junctions / Q000378:metabolism / Q000502:physiology; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001813:Blood-Retinal Barrier / Q000033:anatomy & histology / Q000378:metabolism* / Q000502:physiology; D002199:Capillary Permeability; D002462:Cell Membrane / Q000378:metabolism; D060833:Cellular Microenvironment; D042783:Endothelial Cells / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009457:Neuroglia / Q000378:metabolism; D012160:Retina / Q000033:anatomy & histology / Q000378:metabolism* / Q000502:physiology; D055213:Retinal Pigment Epithelium / Q000098:blood supply / Q000378:metabolism; D019108:Tight Junctions / Q000378:metabolism* / Q000502:physiology
chemical_list: D000596:Amino Acids; D026901:Membrane Transport Proteins; D005947:Glucose