title: Patients with nonalcoholic fatty liver disease have higher risk of colorectal adenoma after negative baseline colonoscopy.
abstract: OBJECTIVE
  The study aimed to determine whether nonalcoholic fatty liver disease (NAFLD) is an independent risk factor of adenoma after negative baseline colonoscopy.
  
  
  METHODS
  A retrospective cohort study was conducted on 1522 health-check individuals who underwent two consecutive colonoscopies at Taipei Veterans General Hospital between 2003 and 2010. Those developing an adenoma after an initial negative baseline colonoscopy (adenoma group) were compared with those in whom the second colonoscopy was negative (nonadenoma group). Anthropometric measurements, biochemical tests and the presence of NAFLD were compared between the two groups.
  
  
  RESULTS
  The adenoma group had a higher prevalence of NAFLD than the nonadenoma group (55.6% vs 38.8%; P < 0.05). On multivariate logistic regression analysis, NAFLD was an independent risk factor (OR = 1.45, 95% CI: 1.07-1.98) for adenoma formation after a negative baseline colonoscopy. The risk of colorectal adenoma increased when NAFLD patients had other morbidities including metabolic syndrome, hypertension or smoking (OR = 2.85, 4.03 and 4.17).
  
  
  CONCLUSIONS
  NAFLD is an independent risk factor for colorectal adenoma formation after a negative baseline colonoscopy. The risk is higher in individuals with NAFLD and other comorbidities, such as hypertension, smoking or metabolic syndrome.
authors: Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors: K-W
authors: KW
authors: Huang
authors: H-B
authors: HB
authors: Leu
authors: Y-J
authors: YJ
authors: Wang
authors: J-C
authors: JC
authors: Luo
authors: H-C
authors: HC
authors: Lin
authors: F-Y
authors: FY
authors: Lee
authors: W-L
authors: WL
authors: Chan
authors: J-K
authors: JK
authors: Lin
authors: F-Y
authors: FY
authors: Chang
mesh_terms: D000236:Adenoma / Q000453:epidemiology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D005234:Fatty Liver / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology; D008875:Middle Aged; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology*
keywords: Body mass index; colorectal adenoma; colorectal cancer; metabolic syndrome; nonalcoholic fatty liver disease