title: Ablative or palliative stereotactic body radiotherapy with helical tomotherapy for primary or metastatic lung tumor.
abstract: OBJECTIVE
  To evaluate the feasibility and outcomes of stereotactic body radiotherapy (SBRT) by helical tomotherapy (HT) for patients with primary or secondary lung cancer.
  
  
  METHODS
  Between March 2009 and January 2012, 56 patients were selected as candidates for the study and were divided into two subgroups. The ablative SBRT group included 27 patients with T1-T2 non-small cell lung cancer who received four to five large-dose fractions in two weeks and the palliative SBRT group included 29 patients with lung metastases treated with eight lower-dose fractions in four weeks.
  
  
  RESULTS
  No differences in acute toxicities were found between different fractionation schemes with different overall treatment times. Actuarial local control at 24 months was better for the ablative group (69.6%) than for the palliative one (40.4%) (p=0.0019).
  
  
  CONCLUSIONS
  HT-based SBRT was feasible and well-tolerated. Local control was satisfactory for patients treated with ablative SBRT but unsatisfactory for those treated with palliative SBRT. Outcomes also suggest the use of ablative SBRT fractionation for palliative intent.
authors: IRCCS San Martino-IST-National Cancer Research Institute and University, Lrago Rosanna Benzi 10, 16132 Genoa, Italy.
authors: Michela
authors: M
authors: Marcenaro
authors: Stefano
authors: S
authors: Vagge
authors: Liliana
authors: L
authors: Belgioia
authors: Dario
authors: D
authors: Agnese
authors: Giorgio
authors: G
authors: Lamanna
authors: Elisa
authors: E
authors: Mantero
authors: Marco
authors: M
authors: Gusinu
authors: Stefania
authors: S
authors: Garelli
authors: Francesca
authors: F
authors: Cavagnetto
authors: Stefano
authors: S
authors: Agostinelli
authors: Renzo
authors: R
authors: Corvò
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*