title: [Transplanting neural stem cells in nerve conduit to promote rats facial nerve regeneration].
abstract: OBJECTIVE
  To construct a biodegradable PLGA nerve conduit (NC) filled with NSCs in order to improve facial nerve regeneration.
  
  
  METHODS
  SD rats were subjected to right facial nerve transection, and PLGA NCs filled with NSCs were used to bridge the nerve gap. Facial nerve regeneration was assessed 4 and 12 weeks after surgery, through electrophysiological testing, and morphometric analysis of axons.
  
  
  RESULTS
  Nerve action potential amplitude, and axonal area were significantly greater in the NSCs group than the empty NC group.
  
  
  CONCLUSIONS
  NSCs transplantation may improve regeneration of the facial nerve.
authors: Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, 200031, China.
authors: Yong
authors: Y
authors: Shi
authors: Liang
authors: L
authors: Zhou
authors: Jie
authors: J
authors: Tian
authors: Yang
authors: Y
authors: Wang
mesh_terms: D000818:Animals; D020220:Facial Nerve Injuries / Q000601:surgery*; D005260:Female; D019344:Lactic Acid; D009416:Nerve Regeneration; D058953:Neural Stem Cells / Q000637:transplantation*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid