title: Targeting protein prenylation in progeria.
abstract: A clinical trial of a protein farnesyltransferase inhibitor (lonafarnib) for the treatment of Hutchinson-Gilford progeria syndrome (HGPS) was recently completed. Here, we discuss the mutation that causes HGPS, the rationale for inhibiting protein farnesyltransferase, the potential limitations of this therapeutic approach, and new potential strategies for treating the disease.
authors: Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. sgyoung@mednet
authors: Stephen G
authors: SG
authors: Young
authors: Shao H
authors: SH
authors: Yang
authors: Brandon S J
authors: BS
authors: Davies
authors: Hea-Jin
authors: HJ
authors: Jung
authors: Loren G
authors: LG
authors: Fong
mesh_terms: D000818:Animals; D053144:Cell Nucleus Shape / Q000187:drug effects; D002986:Clinical Trials as Topic; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D051231:Farnesyltranstransferase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D034882:Lamins / Q000378:metabolism; D011371:Progeria / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D017368:Protein Prenylation / Q000187:drug effects*
chemical_list: D004791:Enzyme Inhibitors; D034882:Lamins; D051231:Farnesyltranstransferase
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