title: NMDA receptor activation: two targets for two co-agonists.
abstract: Neuronal N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic plasticity. Their activation requires not only binding of their ligand glutamate and membrane depolarization but also the presence of a co-agonist, glycine or D-serine. An increasing body of experimental evidence suggests that different populations of NMDARs could be gated by different co-agonists. Here we discuss how the spatial distribution of co-agonist sources and uptake mechanisms, together with diffusional properties of the synaptic environment, could shape NMDAR co-agonist supply and therefore NMDAR-dependent plasticity.
authors: Institute of Cellular Neuroscience, University of Bonn, Bonn, Germany. christian.henneberger@ukb.uni-bonn.de
authors: Christian
authors: C
authors: Henneberger
authors: Lucie
authors: L
authors: Bard
authors: Claire
authors: C
authors: King
authors: Alistair
authors: A
authors: Jennings
authors: Dmitri A
authors: DA
authors: Rusakov
mesh_terms: D026962:Amino Acid Transport System ASC / Q000502:physiology; D000818:Animals; D005998:Glycine / Q000378:metabolism*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists* / Q000502:physiology*; D012694:Serine / Q000378:metabolism*; D013569:Synapses / Q000502:physiology
chemical_list: D026962:Amino Acid Transport System ASC; D016194:Receptors, N-Methyl-D-Aspartate; D012694:Serine; D005998:Glycine
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