title: Association between bipolar affective disorder and thyroid dysfunction.
abstract: BACKGROUND
  Bipolar affective disorder may be associated with alterations in thyroid function. A comprehensive thyroid assessment is important for assessing clinical and sub-clinical imbalances linked to a variety of mood disorders like bipolar affective disorder.
  
  
  OBJECTIVE
  To find out the association between bipolar affective disorder and thyroid dysfunction.
  
  
  METHODS
  The present cross-sectional study was conducted at Government District Wenlock Hospital, Mangalore (GDWH), India. A total of 50 newly diagnosed bipolar affective disorder patients and 50 age and sex matched controls without bipolar affective disorder as confirmed by the application of Bipolar Spectrum Diagnostic Scale were included in the study. Thyroid function was assessed among the patients and control group to study the association between bipolar affective disorder and thyroid dysfunction. Odds ratio was calculated to find out the strength of association between thyroid gland dysfunction and bipolar affective disorder.
  
  
  RESULTS
  The mean Bipolar Spectrum Diagnostic Scale score among patients diagnosed with bipolar affective disorder was 20.84 and that of the control group was 1.98. The proportion of thyroid dysfunction among bipolar affective disorder patients and among control group was 14% and 6% respectively. The odds ratio was calculated to be 2.55. Mean T3 values were higher in the bipolar affective disorder patients than the control group and this association was found to be statistically significant (p=0.031). Mean T4 and TSH values were higher among the bipolar affective disorder patients but did not show any significant differences when compared with the control group.
  
  
  CONCLUSIONS
  The present study concludes that a statistically significant association exists between elevated T3 hormone and bipolar affective disorder and observes that the patients with bipolar affective disorder are 2.55 times more commonly associated with thyroid dysfunction.
authors: Department of Internal Medicine, Mercy Catholic Medical Center, Philadelphia (Affiliated to Drexel University College of Medicine), USA.
authors: Vinay Narasimha
authors: VN
authors: Krishna
authors: Ravish
authors: R
authors: Thunga
authors: B
authors: B
authors: Unnikrishnan
authors: Tanuj
authors: T
authors: Kanchan
authors: Mario Joseph
authors: MJ
authors: Bukelo
authors: Rajesh Kumar
authors: RK
authors: Mehta
authors: Anand
authors: A
authors: Venugopal
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D013959:Thyroid Diseases / Q000097:blood / Q000150:complications*; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine