title: Prolonged survival associated with the use of intraoperative carmustine (Gliadel) in a paediatric patient with recurrent grade III astrocytoma.
abstract: A 15-year-old female presented with a middle cranial fossa anaplastic astrocytoma that was completely excised. She received local radiotherapy (54 Gy) and oral temozolomide. Five months after therapy, MRI showed local relapse. She underwent resection of the tumour with implantation of seven carmustine-impregnated wafers (Gliadel). She then received six cycles of procarbazine and lomustine therapy. Three years later, she is well and disease free. This case supports the further investigation of Gliadel in children and young people with relapsed high-grade glioma, particularly in the setting of a second complete resection.
authors: Department of Oncology, Alder Hey Children's NHS Foundation Trust , Liverpool , UK.
authors: B
authors: B
authors: Pizer
authors: A
authors: A
authors: Salehzadeh
authors: A
authors: A
authors: Brodbelt
authors: C
authors: C
authors: Mallucci
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000494:pharmacology*; D001254:Astrocytoma / Q000188:drug therapy / Q000601:surgery; D002330:Carmustine / Q000008:administration & dosage / Q000494:pharmacology*; D003131:Combined Modality Therapy; D004343:Drug Implants; D005260:Female; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage / Q000494:pharmacology*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000601:surgery; D011344:Procarbazine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D004343:Drug Implants; D011344:Procarbazine; D008130:Lomustine; D002330:Carmustine