title: Lipiodolized transarterial chemoembolization in hepatocellular carcinoma patients after curative resection.
abstract: OBJECTIVE
  To explore the effect of lipiodolized transarterial chemoembolization (lip-TACE) in hepatocellular carcinoma (HCC) patients at different risk of recurrence after curative resection.
  
  
  METHODS
  One thousand nine hundred and twenty-four consecutive HCC patients who underwent curative resection were retrospectively analyzed. Patients who underwent resection only were classified into control group, while those received adjuvant lip-TACE were classified into intervention group. Patients were further stratified into 4 groups, that is, tumor ≤5 cm with low or high risk factors, as well as tumor >5 cm with low or high risk factors for recurrence. Tumor number and microscopic tumor thrombus were defined as risk factors for recurrence. The effect of adjuvant lip-TACE on early (<2 year) or late (≥2 year) recurrence was evaluated.
  
  
  RESULTS
  There was no significant difference in recurrence curve between intervention group and control group in each stratum. Adjuvant lip-TACE showed an overall survival benefit in patients with tumor >5 cm and presenting high risk factors, mainly for those with time to recurrence (TTR) <2 years after operation. For them, the median survival was 17 months in the intervention group and 11 months in the control group (P = 0.010). For patients who were confirmed to be recurrence-free at 2 years after operation, it had the negative effect for survival (HR = 1.75, P = 0.004).
  
  
  CONCLUSIONS
  Adjuvant lip-TACE had no preventive effect on recurrence, but may be of benefit to detect early recurrence.
authors: Liver Cancer Institute, Shanghai, China.
authors: Xiaohong
authors: X
authors: Chen
authors: Boheng
authors: B
authors: Zhang
authors: Xin
authors: X
authors: Yin
authors: Zhenggang
authors: Z
authors: Ren
authors: Shuangjian
authors: S
authors: Qiu
authors: Jian
authors: J
authors: Zhou
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D004998:Ethiodized Oil / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012008:Recurrence; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D004998:Ethiodized Oil
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