title: Purification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction.
abstract: Microfluidic devices have shown great potential for the production of positron emission tomography (PET) radiotracers, but most devices have focused only on the synthesis step of the procedure, typically neglecting the other important steps such as [(18)F]fluoride pre-concentration and radiotracer purification that could equally benefit from miniaturisation. Here, we demonstrate the development of microfluidic modules for the purification of PET radiotracers, particularly 2-[(18)F]fluoro-2-deoxy-d-glucose ([(18)F]FDG), via the use of on-chip solid-phase extraction (SPE). In these initial tests, the SPE modules were able to yield [(18)F]FDG with up to 90% radiochemical purity, and methods are proposed for further increasing this value.
authors: Department of Chemistry, The University of Hull, Cottingham Road, Hull HU6 7RX, UK.
authors: Mark D
authors: MD
authors: Tarn
authors: Giancarlo
authors: G
authors: Pascali
authors: Francesco
authors: F
authors: De Leonardis
authors: Paul
authors: P
authors: Watts
authors: Piero A
authors: PA
authors: Salvadori
authors: Nicole
authors: N
authors: Pamme
mesh_terms: D019788:Fluorodeoxyglucose F18 / Q000737:chemistry / Q000302:isolation & purification*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000302:isolation & purification*; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18