title: Reduced serum beta-trace protein is associated with metabolic syndrome.
abstract: OBJECTIVE
  β-trace protein (BTP), also known as lipocalin-type prostaglandin D2 synthase, has shown to regulate glucose and lipid metabolism in vivo. We sought to study the relationship of serum BTP with diabetes and metabolic syndrome (MetS).
  
  
  METHODS
  Data on 3136 participants aged ≥20 years of the National Health and Nutrition Examination Survey III were examined. Logistic regression was used to assess the association of BTP with diabetes and MetS.
  
  
  RESULTS
  Reduced levels of BTP were associated with diabetes and MetS in age, sex, and race/ethnicity adjusted models. After further multivariable adjustment, BTP levels in quartile 1 remained significantly associated with MetS (odds ratio 2.04 [95% CI 1.14-3.70], Ptrend = 0.003) when compared with quartile 4. Among the five components of MetS, BTP was associated with hypertriglyceridemia (Ptrend < 0.001) but not diabetes (Ptrend = 0.099).
  
  
  CONCLUSIONS
  MetS is associated with a reduced serum level of BTP.
authors: Division of Clinical Pharmacology and Therapeutics, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors: Ching-Lung
authors: CL
authors: Cheung
authors: Tommy T
authors: TT
authors: Cheung
authors: Karen S L
authors: KS
authors: Lam
authors: Bernard M Y
authors: BM
authors: Cheung
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D050356:Lipid Metabolism; D054834:Lipocalins / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D009749:Nutrition Surveys; D012044:Regression Analysis; D014481:United States
chemical_list: D015415:Biomarkers; D054834:Lipocalins; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase; D005947:Glucose