title: A functional [NiFe]hydrogenase mimic that catalyzes electron and hydride transfer from H2.
abstract: Chemists have long sought to mimic enzymatic hydrogen activation with structurally simpler compounds. Here, we report a functional [NiFe]-based model of [NiFe]hydrogenase enzymes. This complex heterolytically activates hydrogen to form a hydride complex that is capable of reducing substrates by either hydride ion or electron transfer. Structural investigations were performed by a range of techniques, including x-ray diffraction and neutron scattering, resulting in crystal structures and the finding that the hydrido ligand is predominantly associated with the Fe center. The ligand's hydridic character is manifested in its reactivity with strong acid to liberate H(2).
authors: World Premier International Research Center Initiative-International Institute for Carbon-Neutral Energy Research, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan. ogotcm@mail.cstm.kyushu-u.ac.jp
authors: Seiji
authors: S
authors: Ogo
authors: Koji
authors: K
authors: Ichikawa
authors: Takahiro
authors: T
authors: Kishima
authors: Takahiro
authors: T
authors: Matsumoto
authors: Hidetaka
authors: H
authors: Nakai
authors: Katsuhiro
authors: K
authors: Kusaka
authors: Takashi
authors: T
authors: Ohhara
mesh_terms: D002384:Catalysis; D004583:Electrons; D006859:Hydrogen / Q000737:chemistry*; D006864:Hydrogenase / Q000737:chemistry* / Q000378:metabolism; D007501:Iron / Q000737:chemistry*; D008024:Ligands; D008956:Models, Chemical; D018716:Molecular Mimicry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D008024:Ligands; D009942:Organometallic Compounds; D009532:Nickel; D006859:Hydrogen; D007501:Iron; C043296:nickel-iron hydrogenase; D006864:Hydrogenase