title: Selective dissociation between core and extended regions of the face processing network in congenital prosopagnosia.
abstract: There is growing consensus that accurate and efficient face recognition is mediated by a neural circuit composed of a posterior "core" and an anterior "extended" set of regions. Here, we characterize the distributed face network in human individuals with congenital prosopagnosia (CP)-a lifelong impairment in face processing-relative to that of matched controls. Using functional magnetic resonance imaging, we first uncover largely normal activation patterns in the posterior core face patches in CP. We also document normal activity of the amygdala (emotion processing) as well as normal or even enhanced functional connectivity between the amygdala and the core regions. Critically, in the same individuals, activation of the anterior temporal cortex (identity processing) is reduced and connectivity between this region and the posterior core regions is disrupted. The dissociation between the neural profiles of the anterior temporal lobe and amygdala was evident both during a task-related face scan and during a resting state scan, in the absence of visual stimulation. Taken together, these findings elucidate selective disruptions in neural circuitry in CP and offer an explanation for the known differential difficulty in identity versus emotional expression recognition in many individuals with CP.
authors: Department of Psychology, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
authors: Galia
authors: G
authors: Avidan
authors: Michal
authors: M
authors: Tanzer
authors: Fadila
authors: F
authors: Hadj-Bouziane
authors: Ning
authors: N
authors: Liu
authors: Leslie G
authors: LG
authors: Ungerleider
authors: Marlene
authors: M
authors: Behrmann
mesh_terms: D000328:Adult; D000679:Amygdala / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005145:Face; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D020238:Prosopagnosia / Q000151:congenital* / Q000503:physiopathology; D012146:Rest / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013702:Temporal Lobe / Q000503:physiopathology; D055815:Young Adult
keywords: face processing; functional connectivity; neurodevelopmental disorders; prosopagnosia; ventral visual cortex
references: Cereb Cortex. 2012 Jul;22(7):1564-76
references: 21893680
references: Neuropsychologia. 2011 Jul;49(9):2541-52
references: 21601583
references: Cereb Cortex. 2010 Apr;20(4):813-25
references: 19620621
references: Exp Brain Res. 2007 Jan;176(2):356-73
references: 16917773
references: Brain Cogn. 2006 Jul;61(2):139-58
references: 16466839
references: Curr Biol. 2011 Oct 11;21(19):1654-60
references: 21962712
references: Cortex. 2014 Jul;56:111-20
references: 23099263
references: J Cogn Neurosci. 2007 Nov;19(11):1790-802
references: 17958482
references: Brain. 1992 Feb;115 Pt 1:15-36
references: 1559150
references: Front Hum Neurosci. 2011 Jun 01;5:55
references: 21687793
references: Exp Brain Res. 2011 Feb;208(4):491-505
references: 21113581
references: Neuropsychologia. 2007 Jan 7;45(1):32-41
references: 16797608
references: J Cogn Neurosci. 2005 Jan;17(1):73-83
references: 15701240
references: Science. 2010 Nov 5;330(6005):845-51
references: 21051642
references: Neuroreport. 1999 Mar 17;10(4):823-7
references: 10208555
references: J Cogn Neurosci. 2011 Jul;23(7):1723-40
references: 20617881
references: Neuroimage. 2006 May 1;30(4):1313-24
references: 16413791
references: Trends Cogn Sci. 2005 Apr;9(4):180-7
references: 15808500
references: Neuron. 2003 Mar 27;37(6):1027-41
references: 12670430
references: Front Hum Neurosci. 2010 Sep 24;4:176
references: 21151362
references: Nat Neurosci. 2006 Sep;9(9):1177-85
references: 16892057
references: Nat Neurosci. 2008 Aug;11(8):877-9
references: 18622399
references: Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5591-6
references: 18375769
references: Brain. 2003 Nov;126(Pt 11):2381-95
references: 12876150
references: Neuropsychologia. 2010 May;48(6):1828-41
references: 20227431
references: Cereb Cortex. 2010 Sep;20(9):2027-42
references: 20051364
references: Trends Cogn Sci. 2000 Jun;4(6):223-233
references: 10827445
references: J Cogn Neurosci. 2003 Apr 1;15(3):419-31
references: 12729493
references: J Cogn Neurosci. 2000 May;12(3):495-504
references: 10931774
references: J Neuropsychol. 2008 Mar;2(1):141-64
references: 19334309
references: Cogn Neuropsychol. 2007 Jun;24(4):419-30
references: 18416499
references: J Cogn Neurosci. 1997 Fall;9(5):605-10
references: 23965119
references: Cortex. 2007 Aug;43(6):718-33
references: 17710824
references: J Neurosci. 1997 Jun 1;17(11):4302-11
references: 9151747
references: Behav Brain Res. 2009 Mar 2;198(1):179-85
references: 19041896
references: Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9998-10003
references: 21628569
references: Psychol Methods. 2001 Dec;6(4):371-86
references: 11778678
references: Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20600-5
references: 18077383
references: Cereb Cortex. 2007 Oct;17(10):2354-63
references: 17218483
references: Neuroimage. 2008 Apr 1;40(2):415-419
references: 18063389
references: Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1995-2000
references: 19179278
references: J Neurosci. 2011 Jul 13;31(28):10323-30
references: 21753009
references: J Cogn Neurosci. 2007 Jan;19(1):132-46
references: 17214570
references: Hum Brain Mapp. 2002 Jul;16(3):176-82
references: 12112771
references: Neurosci Lett. 2009 Apr 17;454(1):1-5
references: 19429043
references: Cortex. 2008 Sep;44(8):996-1009
references: 18597749
references: J Cogn Neurosci. 2005 Jul;17(7):1150-67
references: 16102242
references: Cereb Cortex. 2007 Oct;17(10):2400-6
references: 17190969
references: Curr Biol. 2009 Jul 14;19(13):1146-50
references: 19481456
references: Neuropsychologia. 2011 Sep;49(11):3145-50
references: 21802435
references: J Cogn Neurosci. 2005 Jul;17(7):1130-49
references: 16102241
references: Nat Neurosci. 2009 Jan;12(1):29-31
references: 19029889
references: Neurocase. 2001;7(1):15-27
references: 11239073
references: Neurology. 2003 Jul 22;61(2):220-5
references: 12874402
references: Perception. 2003;32(7):827-38
references: 12974568
references: Psychol Methods. 2008 Sep;13(3):272-7
references: 18778155