title: Treatment strategies for pulmonary sequestration in childhood: resection, embolization, observation?
abstract: BACKGROUND
  The ideal treatment strategy for pulmonary sequestration whether resection or embolization in childhood is not clearly defined. Our institution has no clear policy, therefore both therapies are performed.
  
  
  OBJECTIVE
  The aim of this study was to assess local management strategies of children presenting with pulmonary sequestrations.
  
  
  METHODS
  This is a retrospective, single-institutional review. The main inclusion criterion was the established diagnosis of a pulmonary sequestration. Forty-eight patients were divided into three groups based on treatment received: conservative management (n = 5), surgery (n = 22) and embolization (n = 21).
  
  
  RESULTS
  The median age at treatment was 8.0 months (range 1.2- 166.0) in the surgical, 4.0 months (range 0.2 - 166.0) in the embolization and 8 months (range 0.3 - 197.0) in the conservatively managed groups, respectively. Age at treatment was similar in the surgical and embolization groups (P = 0.9). Recurrent chest infections were the most common clinical presentation in the surgical group, whilst cardiac failure was the most frequent symptom in the embolization group (P < 0.01; 95% CI: 0.3 to 0.9). There were six complications in the surgical group and one in the embolization group (P = 0.1). In one patient embolization was not possible. Outcomes in both groups were comparable with good results on follow-up.
  
  
  CONCLUSIONS
  Both surgery and endovascular embolization are effective and safe treatments for pulmonary sequestration. The presenting symptoms dictate therapy: surgery if there is infection and embolization if a shunt needs to be abolished. Our institutional policy remains unchanged.
authors: Pediatric and Congenital Cardiology, University Hospitals Leuven, Belgium.
authors: Stephen C
authors: SC
authors: Brown
authors: Mark
authors: M
authors: De Laat
authors: Marijka
authors: M
authors: Proesmans
authors: Kris
authors: K
authors: De Boeck
authors: Dirk
authors: D
authors: Van Raemdonck
authors: Jacoba
authors: J
authors: Louw
authors: Ruth
authors: R
authors: Heying
authors: Bjorn
authors: B
authors: Cools
authors: Benedicte
authors: B
authors: Eyskens
authors: Marc
authors: M
authors: Gewillig
mesh_terms: D001998:Bronchopulmonary Sequestration / Q000175:diagnosis / Q000628:therapy*; D002675:Child, Preschool; D004621:Embolization, Therapeutic / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011013:Pneumonectomy / Q000379:methods* / Q000592:standards; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome