title: Is liver transplantation using organs donated after cardiac death cost-effective or does it decrease waitlist death by increasing recipient death?
abstract: OBJECTIVE
  The aim of this study was to evaluate the cost-effectiveness in liver transplantation (LT) of utilizing organs donated after cardiac death (DCD) compared with organs donated after brain death (DBD).
  
  
  METHODS
  A Markov-based decision analytic model was created to compare two LT waitlist strategies distinguished by organ type: (i) DBD organs only, and (ii) DBD and DCD organs. The model simulated outcomes for patients over 10 years with annual cycles through one of four health states: survival; ischaemic cholangiopathy; retransplantation, and death. Baseline values and ranges were determined from an extensive literature review. Sensitivity analyses tested model strength and parameter variability.
  
  
  RESULTS
  Overall survival is decreased, and biliary complications and retransplantation are increased in recipients of DCD livers. Recipients of DBD livers gained 5.6 quality-adjusted life years (QALYs) at a cost of US$69 000/QALY, whereas recipients on the DBD + DCD LT waitlist gained 6.0 QALYs at a cost of US$61 000/QALY. The DBD + DCD organ strategy was superior to the DBD organ-only strategy.
  
  
  CONCLUSIONS
  The extension of life and quality of life provided by DCD LT to patients on the waiting list who might otherwise not receive a liver transplant makes the continued use of DCD livers cost-effective.
authors: Departments of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232-4753, USA.
authors: Leigh Anne
authors: LA
authors: Dageforde
authors: Irene D
authors: ID
authors: Feurer
authors: C Wright
authors: CW
authors: Pinson
authors: Derek E
authors: DE
authors: Moore
mesh_terms: D001926:Brain Death; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D006085:Graft Survival; D017048:Health Care Costs; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000191:economics* / Q000401:mortality*; D008390:Markov Chains; D009010:Monte Carlo Method; D011183:Postoperative Complications / Q000191:economics* / Q000401:mortality* / Q000601:surgery; D015397:Program Evaluation; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012086:Reoperation / Q000191:economics / Q000401:mortality; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D009927:Tissue and Organ Procurement / Q000191:economics*; D016896:Treatment Outcome; D014850:Waiting Lists / Q000401:mortality*
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