title: Platelet activating factor in heart failure: potential role in disease progression and novel target for therapy.
abstract: Heart failure (HF) is a complex syndrome with cardiac, renal, neurohormonal and sympathetic nervous system's manifestations, the pathogenesis of which among others is connected to inflammation. PAF has local and systemic effects pertaining to HF progression since it causes a negative inotropic effect, it induces arrhythmias, it induces apoptosis and it is involved in inflammation and atherosclerosis. In the present review the role of PAF in HF will be thoroughly presented along with the relevant data on PAF enzymes and the potential role of PAF metabolic circuit as a novel pharmacological target.
authors: Department of Nutrition, General Hospital Korgialenio-Benakio, Athanasaki 1, Athens, Greece. viviandeto@yahoo.gr
authors: Paraskevi
authors: P
authors: Detopoulou
authors: Tzortzis
authors: T
authors: Nomikos
authors: Elizabeth
authors: E
authors: Fragopoulou
authors: Christina
authors: C
authors: Chrysohoou
authors: Smaragdi
authors: S
authors: Antonopoulou
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use; D018450:Disease Progression; D015195:Drug Design; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D017202:Myocardial Ischemia / Q000503:physiopathology; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D002316:Cardiotonic Agents; D010972:Platelet Activating Factor
references: Nat Rev Cardiol. 2011 Jan;8(1):30-41
references: 21060326
references: Fed Proc. 1981 Jun;40(8):2285-90
references: 7016598
references: Agents Actions Suppl. 1992;38 ( Pt 3):209-16
references: 1334351
references: Exp Biol Med (Maywood). 2011 Apr 1;236(4):390-401
references: 21378031
references: Jpn Circ J. 1996 Mar;60(3):137-41
references: 8741238
references: Clin Sci (Lond). 1988 Apr;74(4):393-6
references: 3356112
references: Int J Cardiol. 2010 Aug 6;143(1):86-93
references: 19237210
references: Arteriosclerosis. 1990 Mar-Apr;10(2):246-55
references: 2317158
references: Exp Toxicol Pathol. 1995 Dec;47(6):463-70
references: 8871085
references: J Clin Invest. 1984 Oct;74(4):1193-203
references: 6480824
references: J Immunol. 1988 Dec 1;141(11):3945-50
references: 3141509
references: J Lipid Mediat. 1992 Sep;5(3):313-9
references: 1467464
references: J Clin Invest. 1981 Mar;67(3):903-6
references: 7204562
references: Circ Heart Fail. 2009 Sep;2(5):429-36
references: 19808373
references: J Cardiovasc Electrophysiol. 1996 Feb;7(2):120-33
references: 8853022
references: Angiology. 2013 Oct;64(7):522-8
references: 23000600
references: Br J Pharmacol. 1987 Apr;90(4):771-83
references: 3034369
references: Physiol Rev. 2000 Oct;80(4):1669-99
references: 11015622
references: Biochem Biophys Res Commun. 1983 Jun 15;113(2):666-71
references: 6870880
references: Biochim Biophys Acta. 1995 Feb 9;1254(3):231-49
references: 7857964
references: Curr Opin Pharmacol. 2004 Apr;4(2):171-6
references: 15063362
references: J Am Coll Cardiol. 2008 Apr 29;51(17):1632-41
references: 18436114
references: Biochim Biophys Acta. 1997 Sep 4;1348(1-2):111-6
references: 9370322
references: Crit Rev Clin Lab Sci. 2003 Dec;40(6):643-72
references: 14708958
references: Am J Pathol. 1993 Feb;142(2):471-80
references: 8434642
references: Biol Trace Elem Res. 1995 Oct;50(1):43-55
references: 8546883
references: Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2775-84
references: 18441203
references: Anat Embryol (Berl). 1997 Jul;196(1):1-11
references: 9242884
references: Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;87(1):41-6
references: 2885139
references: Can J Cardiol. 2003 Mar 15;19(3):267-74
references: 12677282
references: Am J Physiol. 1989 Apr;256(4 Pt 2):H1236-46
references: 2539755
references: J Biol Chem. 1979 Oct 10;254(19):9355-8
references: 489536
references: Res Commun Chem Pathol Pharmacol. 1990 Feb;67(2):201-18
references: 2333409
references: J Clin Invest. 1995 May;95(5):2297-303
references: 7537762
references: Biomed Biochim Acta. 1988;47(10-11):S219-23
references: 3248107
references: Nutr Metab Cardiovasc Dis. 2006 Apr;16(3):174-85
references: 16580585
references: Atherosclerosis. 1989 Aug;78(2-3):151-8
references: 2783199
references: Cytokine. 2011 Dec;56(3):593-9
references: 21924921
references: Immunopharmacology. 1984 Dec;8(3-4):137-42
references: 6083990
references: Int J Cardiol. 2013 Sep 20;168(1):132-8
references: 23103135
references: Int J Tissue React. 1986;8(6):497-504
references: 3025124
references: Biochim Biophys Acta. 1994 Jun 2;1212(3):353-60
references: 8199206
references: Biomarkers. 2011 Nov;16(7):587-9
references: 21942556
references: Microvasc Res. 2007 Jan;73(1):29-34
references: 17027041
references: Circulation. 2001 May 22;103(20):2495-500
references: 11369691
references: Biochem Biophys Res Commun. 1988 Nov 15;156(3):1293-301
references: 2847729
references: Mol Cell Biochem. 1990 Mar 5;93(1):69-76
references: 2329995
references: Clin Chim Acta. 2004 Jun;344(1-2):163-71
references: 15149885
references: Am Heart J. 2010 Oct;160(4):655-61
references: 20934559
references: J Biol Chem. 2007 Mar 2;282(9):6532-9
references: 17182612
references: Clin Biochem. 2009 Jan;42(1-2):44-9
references: 18955040
references: J Clin Invest. 1991 Dec;88(6):2106-16
references: 1661298
references: Proc Natl Acad Sci U S A. 1990 Apr;87(8):3215-9
references: 2158106
references: J Med Food. 2006 Fall;9(3):356-62
references: 17004898
references: Cardiology. 2012;122(1):23-35
references: 22699305
references: Int J Surg. 2009 Dec;7(6):490-8
references: 19540944
references: Am J Physiol. 1994 Mar;266(3 Pt 1):E403-9
references: 8166260
references: Eur Heart J. 2006 Oct;27(19):2346-52
references: 16952920
references: Int J Cardiol. 1999 Apr 30;69(1):77-82
references: 10362376
references: J Cardiovasc Pharmacol. 1987 Feb;9(2):181-6
references: 2435996
references: Circulation. 2008 Sep 9;118(11):1172-82
references: 18765397
references: Pharmacol Toxicol. 1995 Jun;76(6):343-7
references: 7479573
references: Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1411-6
references: 17431184
references: J Appl Genet. 2010;51(3):353-68
references: 20720311
references: Cardiovasc Res. 2003 Nov 1;60(2):242-9
references: 14613853
references: Trends Cardiovasc Med. 2001 Apr-May;11(3-4):103-12
references: 11685998
references: Biochem Pharmacol. 1992 Jul 22;44(2):223-9
references: 1322663
references: Lipids. 1991 Dec;26(12):1218-22
references: 1819708
references: Angiology. 2011 Apr;62(3):209-18
references: 20805097
references: Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2024-30
references: 12003807
references: Life Sci. 1988;42(6):623-33
references: 3339951
references: Prostaglandins. 1988 Jun;35(6):939-44
references: 2903520
references: J Biol Chem. 2008 Apr 25;283(17):11097-106
references: 18285344
references: Atherosclerosis. 2009 Apr;203(2):593-8
references: 18789441
references: Br J Pharmacol. 1986 Dec;89(4):749-57
references: 3814909
references: Circ Res. 1984 Feb;54(2):117-24
references: 6692502
references: Semin Thromb Hemost. 2012 Jul;38(5):506-14
references: 22399308
references: Cell Physiol Biochem. 2011;27(3-4):363-72
references: 21471725
references: Angiology. 1994 Jan;45(1):25-36
references: 8285381
references: J Pharmacol Exp Ther. 1988 Apr;245(1):124-8
references: 3361438
references: Experientia. 1984 Jul 15;40(7):697-9
references: 6086382
references: Br J Pharmacol. 1986 Jul;88(3):595-605
references: 3091131
references: Acta Pharmacol Sin. 2011 Oct;32(10):1253-8
references: 21970837
references: Lancet. 2010 May 1;375(9725):1536-44
references: 20435228
references: Cardiovasc Drugs Ther. 2009 Feb;23(1):73-83
references: 18949548
references: Int J Cardiol. 2007 Apr 25;117(2):282-4
references: 16899309
references: Heart Vessels. 2012 Nov;27(6):576-84
references: 21947607
references: Presse Med. 1986 Sep 25;15(31):1516-9
references: 2947091
references: Eur Heart J. 2012 Jul;33(14):1787-847
references: 22611136
references: Naunyn Schmiedebergs Arch Pharmacol. 1987 Oct;336(4):459-63
references: 3431598
references: Prostaglandins Leukot Med. 1987 Jun;28(1):103-9
references: 3112804
references: PLoS One. 2011;6(8):e23425
references: 21909350