title: Epidemic of lung cancer in patients with HIV infection.
abstract: The survival of patients with HIV infection has improved dramatically over the past 20 years, largely owing to a significant reduction in opportunistic infections and AIDs-defining malignancies, such as lymphoma and Kaposi sarcoma. However, with improved survival, patients with HIV are experiencing morbidity and mortality from other (non-AIDs-defining) complications, such as solid organ malignancies. Of these, the leading cause of mortality in the HIV-infected population is lung cancer, accounting for nearly 30% of all cancer deaths and 10% of all non-HIV-related deaths. Importantly, the average age of onset of lung cancer in the HIV-infected population is 25 to 30 years earlier than that in the general population and at lower exposure to cigarette smoke. This article provides an overview of the epidemiology of lung cancer in the HIV-infected population and discusses some of the important risk factors and pathways that may enhance the risk of lung cancer in this population.
authors: Division of Respiratory Medicine, Department of Medicine, University of British Columbia, BC, Canada.
authors: Tiffany A
authors: TA
authors: Winstone
authors: Division of Respiratory Medicine, Department of Medicine, University of British Columbia, BC, Canada; UBC James Hogg Research Center, St. Paul's Hospital, Vancouver, BC, Canada.
authors: S F Paul
authors: SFP
authors: Man
authors: Division of AIDS, Department of Medicine, University of British Columbia, BC, Canada; Institute for Heart + Lung Health, and British Columbia Centre for Excellence in HIV/AIDs, St. Paul's Hospital, Vancouver, BC, Canada.
authors: Mark
authors: M
authors: Hull
authors: Division of AIDS, Department of Medicine, University of British Columbia, BC, Canada; Institute for Heart + Lung Health, and British Columbia Centre for Excellence in HIV/AIDs, St. Paul's Hospital, Vancouver, BC, Canada.
authors: Julio S
authors: JS
authors: Montaner
authors: Division of Respiratory Medicine, Department of Medicine, University of British Columbia, BC, Canada; UBC James Hogg Research Center, St. Paul's Hospital, Vancouver, BC, Canada. Electronic address: don.sin@hli.ubc.ca.
authors: Don D
authors: DD
authors: Sin
mesh_terms: D058872:Epidemics; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
references: N Engl J Med. 2011 Aug 4;365(5):395-409
references: 21714641
references: Chest. 2012 May;141(5):1147-1152
references: 22553261
references: Ann Intern Med. 2005 Feb 15;142(4):233-9
references: 15710956
references: Am J Epidemiol. 2001 Sep 15;154(6):544-56
references: 11549560
references: J Int Assoc Physicians AIDS Care (Chic). 2010 Jul-Aug;9(4):214-7
references: 20798400
references: AIDS. 2000 Mar 31;14(5):553-9
references: 10780718
references: J Clin Oncol. 2006 Mar 20;24(9):1383-8
references: 16549832
references: Cancer. 2000 Feb 1;88(3):563-9
references: 10649248
references: Chest. 1992 Dec;102(6):1704-8
references: 1446476
references: Int J Cancer. 2008 Jul 1;123(1):187-94
references: 18435450
references: JAMA. 2001 Apr 4;285(13):1736-45
references: 11277828
references: J Natl Cancer Inst. 2011 May 4;103(9):753-62
references: 21483021
references: Int J STD AIDS. 1999 Dec;10(12):795-802
references: 10639060
references: Clin Infect Dis. 2007 Jul 1;45(1):103-10
references: 17554710
references: J Acquir Immune Defic Syndr. 2009 Dec;52(5):611-22
references: 19770804
references: JAMA. 2012 Jun 13;307(22):2418-29
references: 22610500
references: N Engl J Med. 2009 Apr 30;360(18):1815-26
references: 19339714
references: AIDS. 2012 May 15;26(8):1017-25
references: 22382152
references: Am J Epidemiol. 2007 May 15;165(10):1143-53
references: 17344204
references: Lung Cancer. 1996 Nov;15(3):325-39
references: 8959678
references: Lung Cancer. 2009 Sep;65(3):345-50
references: 19135758
references: Clin Infect Dis. 2005 Feb 1;40(3):490-1
references: 15668878
references: Br J Surg. 1997 Aug;84(8):1068-71
references: 9278642
references: J Clin Oncol. 2009 Feb 20;27(6):884-90
references: 19114688
references: Chest. 1993 Feb;103(2):410-3
references: 8432128
references: J Clin Oncol. 2010 Mar 20;28(9):1514-9
references: 20177022
references: Clin Lung Cancer. 2010 Nov 1;11(6):396-404
references: 21062730
references: Lancet. 2007 Jul 7;370(9581):59-67
references: 17617273
references: AIDS. 2006 Aug 1;20(12):1645-54
references: 16868446
references: AIDS. 2008 Feb 19;22(4):489-96
references: 18301061
references: J Acquir Immune Defic Syndr. 2010 Nov;55(3):375-9
references: 20736841
references: Br J Cancer. 2009 Mar 10;100(5):840-7
references: 19223894
references: Am J Pathol. 2009 May;174(5):1931-9
references: 19349353
references: Cell Mol Life Sci. 2000 May;57(5):851-8
references: 10892349
references: J Acquir Immune Defic Syndr. 2005 Jul 1;39(3):293-9
references: 15980688
references: J Acquir Immune Defic Syndr. 2006 Sep;43(1):47-55
references: 16936558
references: Br J Cancer. 2012 Jan 31;106(3):447-52
references: 22240797
references: Chest. 1998 Jan;113(1):154-61
references: 9440583
references: Lancet Oncol. 2009 Dec;10(12):1152-9
references: 19818686
references: Expert Rev Anticancer Ther. 2008 Apr;8(4):605-15
references: 18402527
references: J Acquir Immune Defic Syndr. 2010 Dec;55(4):510-5
references: 20838223
references: J Clin Epidemiol. 2001 Dec;54 Suppl 1:S29-34
references: 11750207
references: JAMA. 2000 Jun 28;283(24):3244-54
references: 10866874
references: Ann Intern Med. 2010 Oct 5;153(7):452-60
references: 20921544
references: Ann Intern Med. 2008 May 20;148(10):728-36
references: 18490686
references: Med Oncol. 2004;21(2):109-15
references: 15299182
references: JAMA. 1998 May 20;279(19):1554-9
references: 9605900
references: Immunol Invest. 1997 Apr;26(3):351-70
references: 9129988
references: AIDS. 2007 Jan 11;21(2):207-13
references: 17197812
references: AIDS. 2003 Feb 14;17(3):371-5
references: 12556691
references: Cancer. 2012 Jan 1;118(1):164-72
references: 21713759
references: J Thorac Oncol. 2007 Apr;2(4):268-72
references: 17409796
references: J Clin Oncol. 2003 Sep 15;21(18):3447-53
references: 12972519
references: J Natl Cancer Inst. 2005 Mar 16;97(6):425-32
references: 15770006
references: AIDS. 2009 Nov 13;23(17):2337-45
references: 19741479
references: Clin Infect Dis. 2008 Nov 15;47(10):1345-53
references: 18834317
references: BMC Cancer. 2011 Jun 25;11:272
references: 21702995
references: J Acquir Immune Defic Syndr. 2009 Oct 1;52(2):203-8
references: 19617846
references: Br J Cancer. 2003 Aug 4;89(3):457-9
references: 12888811