title: Sex differences in the neural bases of social appraisals.
abstract: Behavioral research has demonstrated an advantage for females compared with males in social information processing. However, little is known about sex-related differences in brain activation during understanding of self and others. In the current functional magnetic resonance imaging study, this was assessed in late adolescents (aged 18-19) and young adults (aged 23-25) when making appraisals of self and other as well as reflected self-appraisals. Across all groups and for all appraisal conditions, activation was observed in the medial prefrontal cortex, medial posterior parietal cortex, left and right dorsolateral prefrontal cortex and left posterior parietal cortex. Males activated the medial posterior parietal cortex and bilateral temporoparietal junction more than females. The precuneus showed stronger activation in males compared with females specifically during appraisals of others. No differences between late adolescents and young adults were found. These results indicate that sex differences exist in the neural bases of social understanding.
authors: Department of Educational Neuroscience, Faculty of Psychology and Education & LEARN! Institute, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands. k.veroude@vu.nl.
authors: Kim
authors: K
authors: Veroude
authors: Jelle
authors: J
authors: Jolles
authors: Gerda
authors: G
authors: Croiset
authors: Lydia
authors: L
authors: Krabbendam
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011930:Reaction Time; D012649:Self Concept; D012727:Sex Characteristics; D012938:Social Perception; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: age; brain; males; other; self
references: Nat Rev Neurosci. 2012 Sep;13(9):636-50
references: 22903221
references: Am Psychol. 2000 May;55(5):469-80
references: 10842426
references: Trends Cogn Sci. 2002 Jun 1;6(6):248-254
references: 12039606
references: Neuron. 2010 Sep 9;67(5):728-34
references: 20826305
references: J Cogn Neurosci. 2010 Jul;22(7):1623-35
references: 19580380
references: Trends Cogn Sci. 2007 Apr;11(4):153-7
references: 17300981
references: Nature. 2006 Jan 26;439(7075):466-9
references: 16421576
references: Hum Brain Mapp. 2009 Mar;30(3):829-58
references: 18381770
references: Neuropsychologia. 2012 Jun;50(7):1211-21
references: 22245006
references: Front Psychol. 2011 Jan 26;2:3
references: 21713131
references: J Autism Dev Disord. 2004 Apr;34(2):163-75
references: 15162935
references: Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9
references: 15148381
references: Philos Trans R Soc Lond B Biol Sci. 2003 Mar 29;358(1431):459-73
references: 12689373
references: J Cogn Neurosci. 2002 Jul 1;14(5):785-94
references: 12167262
references: Dev Neuropsychol. 2010;35(5):555-69
references: 20721775
references: Brain. 2002 Aug;125(Pt 8):1808-14
references: 12135971
references: Neuron. 2010 Sep 9;67(5):749-60
references: 20826307
references: Neuroimage. 2003 Aug;19(4):1835-42
references: 12948738
references: Child Dev. 2009 Jul-Aug;80(4):1016-38
references: 19630891
references: Psychoneuroendocrinology. 2010 Jan;35(1):67-82
references: 19914001
references: Conscious Cogn. 2011 Mar;20(1):52-63
references: 20932778
references: Hum Brain Mapp. 2012 Jan;33(1):154-64
references: 21391261
references: Biol Psychiatry. 2004 Jun 1;55(11):1047-55
references: 15158422
references: Brain Res. 2006 Mar 24;1079(1):86-97
references: 16490183
references: J Res Adolesc. 2011 Mar 1;21(1):21-33
references: 21475613
references: Soc Cogn Affect Neurosci. 2006 Jun;1(1):18-25
references: 18985097
references: Ann N Y Acad Sci. 2004 Jun;1021:77-85
references: 15251877
references: J Cogn Neurosci. 2004 Jul-Aug;16(6):988-99
references: 15298786
references: J Clin Exp Neuropsychol. 2006 Aug;28(6):998-1009
references: 16822738
references: Neuroimage. 2005 Dec;28(4):797-814
references: 16290016
references: Soc Cogn Affect Neurosci. 2007 Jun;2(2):130-9
references: 17710201
references: BMC Neurosci. 2009 Feb 04;10:9
references: 19193204
references: Curr Opin Neurobiol. 2006 Apr;16(2):235-9
references: 16546372
references: Trends Cogn Sci. 2005 Feb;9(2):69-74
references: 15668099
references: J Clin Exp Neuropsychol. 2012;34(3):227-34
references: 22149348
references: J Cogn Neurosci. 2007 Aug;19(8):1323-37
references: 17651006
references: Neuroimage. 2008 Aug 1;42(1):393-403
references: 18514546
references: Neuroimage. 2005 Apr 1;25(2):616-24
references: 15784441
references: Soc Cogn Affect Neurosci. 2012 Jan;7(1):53-63
references: 21467048
references: Annu Rev Psychol. 2007;58:259-89
references: 17002553
references: Annu Rev Psychol. 2001;52:83-110
references: 11148300
references: Trends Cogn Sci. 2003 Dec;7(12):527-33
references: 14643368
references: Psychol Assess. 2006 Dec;18(4):424-32
references: 17154763