title: [Apolipoprotein E polymorphism and cerebral stroke].
abstract: Our study is the type case-control realized at the Hospital of Constantine, discusses the relationship between polymorphism of apolipoprotein E and stroke.
  
  
  METHODS
  The determination of the polymorphism of apolipoprotein E was carried out by PCR- digestion (polymerase chain reaction) using the enzyme of restriction HhaI. The study population consisted of 218 Algerian patients with stroke (divided into 63% ischemic and 37% hemorrhagic), and 509 control subjects.
  
  
  RESULTS
  Three isoforms of apolipoprotéin E have been identified. The allelic distribution of apo E in the general population showed a predominance of the allele ɛ3 (84.3%) followed distantly by allele ɛ4 (10.7%) and ɛ2 (5%) respectively. ɛ3/ɛ4 genotype was significantly more represented among subjects with ischemic stroke (29.5%) compared with control subjects (18.8%). The odds ratio is 1.72 compared to carriers of the genotype ɛ3/ɛ3 (CI is 95% and p <0.05).
  
  
  CONCLUSIONS
  The distribution of allelic frequencies of apolipoprotein E in the population of Constantine is similar to that of Southern Europe. Our results imply a role of the genotype of apolipoprotein E (ɛ4 allele) in the pathogenesis of stroke and are limited to the accidents of the ischemic type. The ɛ2 allele does not appear to be implied in occurred of this affection; however, large additional studies are necessary to confirm this result.
authors: Laboratoire de biologie et génétique moléculaire, Faculté de médecine, Université Mentouri, Constantine, Algérie. sabboumendjel@yahoo.fr
authors: Sabrina
authors: S
authors: Boumendjel
authors: Djamel
authors: D
authors: Khodja
authors: Abdelmajid
authors: A
authors: Hamri
authors: Chérifa
authors: C
authors: Benlatreche
authors: Noureddine
authors: N
authors: Abadi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000462:Algeria / Q000453:epidemiology; D001057:Apolipoproteins E / Q000235:genetics* / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000502:physiology; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*; D055815:Young Adult
chemical_list: D001057:Apolipoproteins E
keywords: apolipoprotein E; atherosclerosis; genetic polymorphism; stroke