title: Symptomatic late-onset sialadenitis after radioiodine therapy in thyroid cancer.
abstract: OBJECTIVE
  The aim of this study was to document the subjective and objective findings of symptomatic late-onset sialadenitis after radioiodine therapy in patients with differentiated thyroid cancer.
  
  
  METHODS
  Subjective symptoms related to sialadenitis and Tc-99m pertechnetate salivary gland scintigram findings were assessed in 118 patients (26 males, 92 females) both before and during the late phase (mean 338 days) after the administration of radioiodine.
  
  
  RESULTS
  Twelve of the 118 patients (10.2 %) complained of symptomatic sialadenitis in the late phase without symptoms during the early phase (within 7 days of radioiodine administration). Significant associations were found between subjective symptoms and visual scintigram findings during the late phase (p = 0.023). Furthermore, uptake and excretion by both parotid glands were significantly affected by radioiodine therapy.
  
  
  CONCLUSIONS
  Symptomatic late-onset sialadenitis occurred at an incidence of 10.2 %, and salivary gland function was affected in both parotids in most patients.
authors: Department of Nuclear Medicine and Molecular Imaging, School of Medicine, Ajou University, Woncheon-dong, Yeongtong-gu, Suwon, Gyeonggi-do, 443-749, Korea. aysays77@naver.com
authors: Young-Sil
authors: YS
authors: An
authors: Joon-Kee
authors: JK
authors: Yoon
authors: Su Jin
authors: SJ
authors: Lee
authors: Hee-Sung
authors: HS
authors: Song
authors: Seok-Ho
authors: SH
authors: Yoon
authors: Kyung-Sook
authors: KS
authors: Jo
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000453:epidemiology*; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012793:Sialadenitis / Q000453:epidemiology*; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes