title: Indolent course of cutaneous gamma-delta T-cell lymphoma.
abstract: Cutaneous gamma-delta T-cell lymphoma (γδTCL) is a rare malignancy that typically displays an aggressive clinical course. We present an unusual case of a 57-year-old woman with a 3-year history of lower extremity nodules. Histopathologic, immunophenotypic and molecular genetic studies revealed a clonal, predominantly pannicular gamma-delta T-cell infiltrate, leading to a diagnosis of cutaneous γδTCL. The clinical course was characterized by rapid improvement within months of starting systemic corticosteroids, with relapse in ulcerations but no new lesions more than 3 years after onset of disease. Our case and seven previously reported patients with indolent and relatively localized cutaneous γδTCL provide evidence that not all cases of this entity carry a poor prognosis. This indolent subset adds complexity to treatment of cutaneous γδTCL.
authors: College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA.
authors: Dawnielle C
authors: DC
authors: Endly
authors: Roger H
authors: RH
authors: Weenig
authors: Margot S
authors: MS
authors: Peters
authors: David S
authors: DS
authors: Viswanatha
authors: Nneka I
authors: NI
authors: Comfere
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy* / Q000473:pathology*; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D000305:Adrenal Cortex Hormones; D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: connective tissue disease panniculitis; gamma-delta T-cell lymphoma; panniculitic lymphoma