title: [Successful treatment using recombinant thrombomodulin for disseminated intravascular coagulation associated with recurrent prosthetic valve endocarditis].
abstract: Prosthetic valve endocarditis(PVE)occasionally evokes sepsis and disseminated intravascular coagulation(DIC). A 46-year-old man developed relapsing active PVE with an annular abscess and suffered from exacerbating sepsis and DIC. Despite the administration of antibiotics, his DIC score increased. Anti-DIC treatment with recombinant thrombomodulin (rTM) was initiated, and his DIC was remarkably resolved. Accordingly, the abscess cavity was closed by using a homograft anterior mitral leaflet, and the aortic root was replaced with the homograft. He is doing well without an evidence of recurrent endocarditis 18 months after the operation. rTM is a new and promising drug for the treatment of DIC with infective endocarditis.
authors: Division of Cardiovascular Surgery, Tohoku University School of Medicine, Sendai, Japan.
authors: Shinya
authors: S
authors: Masuda
authors: Osamu
authors: O
authors: Adachi
authors: Koki
authors: K
authors: Ito
authors: Satoshi
authors: S
authors: Matsuo
authors: Yukihiro
authors: Y
authors: Hayatsu
authors: Yusuke
authors: Y
authors: Suzuki
authors: Takeshi
authors: T
authors: Saito
authors: Masatoshi
authors: M
authors: Akiyama
authors: Kiichiro
authors: K
authors: Kumagai
authors: Naotaka
authors: N
authors: Motoyoshi
authors: Shunsuke
authors: S
authors: Kawamoto
authors: Yoshikatsu
authors: Y
authors: Saiki
mesh_terms: D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology*; D004696:Endocarditis / Q000150:complications*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000150:complications*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence; D018180:Thrombomodulin / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D018180:Thrombomodulin