title: Level of nitric oxide and antioxidant vitamins in sickle cell anaemia patients.
abstract: Sickle cell anaemia (SCA) is characterized with sever anaemia and vasoocclussive episodes. Nitric Oxide (NO) a potential vasodilator, synthesized from various cells including endothelial cell. However SCA is associated with endothelial dysfunction, a measure cognitive factor for pulmonary hypertension (PH) and vasoocclussive crisis. The present study was attempted to evaluate level of serum NO and plasma antioxidant vitamins A, E and C in homozygous (n = 30) and heterozygous (n = 30) sickle cell patients and compared with age and sex matched healthy controls (n = 30). We found, significantly (P < 0.0001) elevated level of serum NO and significantly (P < 0.0001) depleted antioxidant vitamins in homozygous and heterozygous sickle cell patients compared to healthy controls. Our study reveals that oxidative stress may be a responsible factor for the reduced bioavailability of NO which can impair the vasodilation in sickle cell patients.
authors: Department of Biochemistry, ACPM Medical College, Dhule (Maharashtra), India. pshundekar@gmail.com
authors: Prakash S
authors: PS
authors: Hundekar
authors: Aadinath N
authors: AN
authors: Suryakar
authors: Aarti C
authors: AC
authors: Karnik
authors: Raghvendra V
authors: RV
authors: Katkam
authors: Nitin G
authors: NG
authors: Joshi
authors: Rahul A
authors: RA
authors: Ghone
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood*; D000975:Antioxidants / Q000032:analysis; D001205:Ascorbic Acid / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*; D014815:Vitamins / Q000097:blood*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D014815:Vitamins; D014801:Vitamin A; D014810:Vitamin E; D009569:Nitric Oxide; D001205:Ascorbic Acid