title: Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18(AV-45) positron emission tomography.
abstract: OBJECTIVE
  To examine the association between regional brain uptake of a novel amyloid positron emission tomography (PET) tracer florbetapir F 18 ([(18)F]-AV-45) and cognitive performance in a pilot study.
  
  
  METHODS
  Cross-sectional comparison of [(18)F]-AV-45 in AD patients versus controls.
  
  
  METHODS
  Three specialty memory clinics.
  
  
  METHODS
  Eleven participants with probable Alzheimer disease (AD) by NINDS/ADRDA criteria and 15 healthy comparison (HC) participants.
  
  
  METHODS
  Participants underwent PET imaging following a 370 MBq (10 mCi) intravenous administration of [(18)F]-AV-45. Regional/cerebellar standardized uptake value ratios (SUVRs) were calculated. Cognition was assessed using Mini-Mental State Examination, Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Wechsler Logical Memory IA (immediate recall) test (LMIA), and verbal category fluency.
  
  
  RESULTS
  Greater [(18)F]-AV-45 SUVR was associated with poorer performance on all cognitive tests. In the HC group, occipital, parietal, precuneus, temporal, and cortical average SUVR was associated with greater ADAS-Cog, and greater anterior cingulate SUVR was associated with lower LMIA. Two HC participants had [(18)F]-AV-45 cortical/cerebellar SUVR greater than 1.5, one of whom had deficits in episodic recall and on follow-up met criteria for amnestic mild cognitive impairment.
  
  
  CONCLUSIONS
  [(18)F]-AV-45 SUVR in several brain regions was associated with worse global cognitive performance particularly in HC, suggesting its potential as a marker of preclinical AD.
authors: Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA. prosenb9@jhmi.edu
authors: Paul B
authors: PB
authors: Rosenberg
authors: D F
authors: DF
authors: Wong
authors: S L
authors: SL
authors: Edell
authors: J S
authors: JS
authors: Ross
authors: A D
authors: AD
authors: Joshi
authors: J R
authors: JR
authors: Brašić
authors: Y
authors: Y
authors: Zhou
authors: V
authors: V
authors: Raymont
authors: A
authors: A
authors: Kumar
authors: H T
authors: HT
authors: Ravert
authors: R F
authors: RF
authors: Dannals
authors: M J
authors: MJ
authors: Pontecorvo
authors: D M
authors: DM
authors: Skovronsky
authors: C G
authors: CG
authors: Lyketsos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D016022:Case-Control Studies; D003071:Cognition; D003072:Cognition Disorders / Q000150:complications / Q000378:metabolism* / Q000523:psychology*; D005026:Ethylene Glycols; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010865:Pilot Projects; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D000682:Amyloid; D000814:Aniline Compounds; D015415:Biomarkers; D005026:Ethylene Glycols; D005462:Fluorine Radioisotopes; C545186:florbetapir
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