title: Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population.
abstract: Migraine, a very common headache disorder, is regarded as a polygenic disease and serotonergic pathways appear to play a major role in its pathogenesis. The present study was designed to explore the associations of polymorphisms of 5-hydroxytryptamine (serotonin) receptor 1A (5-HT1A) and 5-hydroxytryptamine receptor 1B (5-HT1B) genes in Turkish migraine patients. 5-HT1A C-1019G (rs6295) promoter and 5-HT1B G861C (rs6296) exon polymorphisms in 203 migraine patients and 202 healthy subjects were analyzed by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Allele and genotype frequencies were not significantly different between migraine patients and healthy subjects for both the 5-HT1A C-1019G promoter and 5-HT1B G861C exon polymorphisms. Our data do not support the hypothesis that 5-HT1A C-1019G and 5-HT1B G861C polymorphisms have effects on migraine.
authors: Gaziosmanpasa University, Medical Faculty, Department of Medical Biology, 60100, Tokat, Turkey.
authors: Omer
authors: O
authors: Ates
authors: Nevin
authors: N
authors: Karakus
authors: Saime
authors: S
authors: Sezer
authors: Nihan
authors: N
authors: Bozkurt
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
chemical_list: D044302:Receptor, Serotonin, 5-HT1B; D044282:Receptor, Serotonin, 5-HT1A