title: Trabecular bone mineral density and bone geometry of the distal radius at completion of pubertal growth in childhood type 1 diabetes.
abstract: OBJECTIVE
  To identify disease-related risk factors for an altered bone mineral density (BMD) and geometry at young adulthood in patients with diabetes mellitus type 1 (DM1).
  
  
  METHODS
  Fifty-six DM1 patients (23 females, 33 males) with prepubertal onset of diabetes were studied after completion of skeletal growth. Bone parameters at the distal radius were investigated by peripheral quantitative computed tomography. Disease-related parameters, in particular average HbA1c during the 2 years around peak height velocity, were analyzed. Forty-seven healthy controls (32 females, 15 males) were studied.
  
  
  RESULTS
  Trabecular BMD was similar between DM1 patients and controls. The mean (±SD) cross-sectional bone area (CSA) was smaller in DM1 patients compared to controls (282.5 ± 45.4 vs. 326.7 ± 52.2 mm(2), p = 0.002 and males 391.0 ± 61.3 vs. 423.4 ± 81.9 mm(2), p = 0.1). In female DM1 patients, the CSA z-score correlated negatively with the body mass index z-score (r = -0.52, p = 0.01) and positively with the height z-score (r = 0.49, p = 0.02).
  
  
  CONCLUSIONS
  DM1 patients are at risk for smaller bone sizes at the distal radius at the end of pubertal growth, especially females with increased adiposity. Diabetes-specific parameters seem to have a low impact on forearm volumetric apparent mineral density.
authors: Department of Pediatrics, UZ Brussel, Brussels, Belgium.
authors: Inge
authors: I
authors: Roggen
authors: Inge
authors: I
authors: Gies
authors: Jesse
authors: J
authors: Vanbesien
authors: Olivia
authors: O
authors: Louis
authors: Jean
authors: J
authors: De Schepper
mesh_terms: D000293:Adolescent; D000328:Adult; D015519:Bone Density; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D009929:Organ Size; D011627:Puberty; D011884:Radius / Q000254:growth & development* / Q000473:pathology*; D012307:Risk Factors
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human