title: Evaluating amyloid Beta (aβ) 1-40 degradation by capillary electrophoresis.
abstract: Here, we describe a capillary electrophoresis method for evaluating proteolysis of the amyloid beta peptide (Aβ) 1-40. This method is suitable for kinetic studies, demands little specialized equipment, and consumes only small quantities of a commercially available substrate whose physiological accumulation is thought to underlie the development of Alzheimer's disease.
authors: Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN, USA.
authors: Benjamin J
authors: BJ
authors: Alper
authors: Walter K
authors: WK
authors: Schmidt
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods / Q000592:standards; D005069:Evaluation Studies as Topic; D006801:Humans; D007339:Insulysin / Q000737:chemistry; D007700:Kinetics; D010446:Peptide Fragments / Q000737:chemistry*; D059748:Proteolysis; D012015:Reference Standards
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D007339:Insulysin