title: Harnessing CD4⁺ T cell responses in HIV vaccine development.
abstract: CD4(+) T cells can perform a panoply of tasks to shape an effective response against a pathogen. Limited attention has been paid to the potential importance of functional CD4(+) T cell responses in the context of the development of next-generation vaccines, including HIV vaccines. Many CD4(+) T cell functions are newly appreciated and only partially understood. A workshop was held as a forum to bring together a small group of experts to exchange ideas on the role of CD4(+) T cells in developing durable functional antibody responses, via follicular helper T cells, as well as on the roles of CD4(+) T cells in other aspects of protective immunity. Here we discuss whether CD4(+) T cell responses may represent a beneficial component of an efficacious HIV vaccine.
authors: US Military HIV Research Program, Henry M. Jackson Foundation, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA. hstreeck@hivresearch.org
authors: Hendrik
authors: H
authors: Streeck
authors: M Patricia
authors: MP
authors: D'Souza
authors: Dan R
authors: DR
authors: Littman
authors: Shane
authors: S
authors: Crotty
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D057134:Antibodies, Neutralizing / Q000096:biosynthesis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015483:HIV Antibodies / Q000096:biosynthesis; D006801:Humans; D054380:Receptors, CXCR5 / Q000032:analysis
chemical_list: D016915:AIDS Vaccines; D057134:Antibodies, Neutralizing; C095085:CXCR5 protein, human; D015483:HIV Antibodies; D054380:Receptors, CXCR5
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