title: Oral candidiasis in patients with renal transplants.
abstract: OBJECTIVE
  Oral candidiasis (OC) is a frequent oral lesion in renal transplant patients (RTPs). Despite the increased prevalence of OC in RTPs, no study has examined related risk factors. The aims of this study were to analyze the prevalence of and risk factors for OC in RTPs compared with age- and gender-matched healthy control group (HC) as well as determine the incidence of OC after transplantation.
  
  
  METHODS
  [corrected] We analyzed the prevalence and risk factors of OC in a group of 500 RTPs (307 men, 193 women, mean age 53.63 years) and 501 HC subjects (314 men, 187 women, mean age 52.25 years). Demographic and pharmacological data were recorded for all subjects. Incident cases of OC were ascertained retrospectively from outpatient clinical records only in the RTP group.
  
  
  RESULTS
  The prevalence of OC was 7.4% in RTPs compared with 4.19% in HC (P<0.03). The most frequent type of OC in the two groups was denture stomatitis. Statistical association was found between OC and age, mycophenolate mofetil dose and blood levels, dentures and tobacco. The multiple logistic regression model only chose for denture variable. According to the outpatient clinical records, 24 RTPs suffered OC during the first moth post-transplant. Severe lesions affecting the oral cavity and pharynx appeared in 79% of the OC cases.
  
  
  CONCLUSIONS
  This study shows a lower prevalence of OC in RTPs than previous reports. Denture stomatitis was the most frequent OC prevalence form described in RTPs. Severe candidiasis is more frequent in the immediate posttransplant period. The presence of denture is an important risk factor of OC. These results emphasise the importance of adequate pre- and post-transplant oral health and denture cleaning and adjustment is recommended for these subjects to prevent this infection.
authors: Department of Oral Medicine and Orofacial Surgery, Faculty of Odontology, Complutense University, Madrid, Spain. rmlopezp@odon.ucm.es
authors: Rosa-María
authors: RM
authors: López-Pintor
authors: Gonzalo
authors: G
authors: Hernández
authors: Lorenzo
authors: L
authors: de Arriba
authors: Amado
authors: A
authors: de Andrés
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002180:Candidiasis, Oral / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
references: J Oral Pathol. 1979 Feb;8(1):53-9
references: 108374
references: Diabet Med. 2006 May;23(5):455-9
references: 16681553
references: J Oral Pathol Med. 1997 Aug;26(7):297-304
references: 9250928
references: Oral Dis. 2010 Jan;16(1):89-95
references: 19656317
references: Am J Gastroenterol. 1994 Jul;89(7):1062-5
references: 8017366
references: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Apr;93(4):455-60
references: 12029285
references: J Am Acad Dermatol. 2010 Jan;62(1):96-101
references: 19926164
references: Aust Dent J. 2010 Jun;55 Suppl 1:48-54
references: 20553244
references: Swed Dent J. 2009;33(3):97-103
references: 19994559
references: Transplant Proc. 2009 Jul-Aug;41(6):2419-21
references: 19715938
references: Crit Rev Oncol Hematol. 2005 Oct;56(1):87-99
references: 15979889
references: Oral Dis. 2005 Sep;11(5):268-73
references: 16120112
references: J Am Acad Dermatol. 2003 Aug;49(2):187-92
references: 12894063
references: Drugs. 2007;67(3):369-91
references: 17335296
references: Transpl Int. 2005 Jun;18(6):643-50
references: 15910287
references: Oral Microbiol Immunol. 2009 Jun;24(3):249-54
references: 19416456
references: Exp Clin Transplant. 2005 Dec;3(2):385-9
references: 16417449
references: Drugs. 2008;68 Suppl 1:3-10
references: 18442296
references: Transpl Infect Dis. 1999 Dec;1(4):229-36
references: 11428994
references: Oral Surg Oral Med Oral Pathol. 1994 Dec;78(6):718-26
references: 7898908
references: Acta Odontol Scand. 1990 Feb;48(1):57-9
references: 2181811
references: Mycoses. 2011 Jul;54(4):337-44
references: 20492525
references: Diabetes Res Clin Pract. 2010 Oct;90(1):81-6
references: 20638146
references: Diabetes Res Clin Pract. 2009 Dec;86(3):239-46
references: 19800143
references: Dent Clin North Am. 2003 Oct;47(4):709-31, vii
references: 14664461
references: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Apr;95(4):383-9
references: 12686921
references: Oral Dis. 2006 May;12(3):309-14
references: 16700742
references: Transplant Proc. 2006 Jan-Feb;38(1):155-6
references: 16504690
references: Med Oral Patol Oral Cir Bucal. 2005 May-Jul;10(3):196-204
references: 15876960