title: TCF7L2 and diabetes: a tale of two tissues, and of two species.
abstract: Human genetics is revealing ever more variants that influence propensity to common diseases, but progress in translating these discoveries into the biological mechanisms responsible for predisposition continues to lag behind. A recent paper in Cell (Boj et al., 2012) using rodent models to examine how diabetes-associated variants near TCF7L2 perturb metabolic regulation provides surprising results.
authors: Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK. mark.mccarthy@drl.ox.ac.uk
authors: Mark I
authors: MI
authors: McCarthy
authors: Patrik
authors: P
authors: Rorsman
authors: Anna L
authors: AL
authors: Gloyn