title: An epidemiological analysis of the incidence of osteoporosis and osteoporosis-related fractures among the Saudi Arabian population.
abstract: OBJECTIVE
  Osteoporosis is common in Saudi Arabia and the burden of management in an aging population will increase in coming decades. There is still no national policy nor consensus on screening for this silent disease. The objective of this analysis was to determine from the published data the prevalence of osteopenia and osteoporosis in Saudi Arabians, the prevalence of secondary osteoporosis, and the prevalence of osteoporosis-related fractures (ORF). We also sought to determine the best age to begin and best modality for screening.
  
  
  METHODS
  Data Sources were MEDLINE (1966 to May 2011), EMBASE (1991 to May 2011), the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews (1952 to May 2011), and the Science Citation Index (1966 to May 2011), published data from the Saudi Medical Journal (1985-2011) and Annals of Saudi Medicine (1985-2011). We selected English-language articles with at least 100 Saudi individuals. Two authors independently reviewed articles and abstracted data.
  
  
  RESULTS
  The authors identified 36 potentially relevant articles, of which 24 met the inclusion criteria. Of 5160 healthy women 50 to 79 years of age (mean, SD: 56.8 [2.7]), 36.6% (6.6%) were osteopenic and 34.0% (8.5%) were osteoporotic. In three studies on males (n=822), the prevalence of osteopenia was 46.3% and osteoporosis 30.7%. Males had a significantly higher frequency of osteopenia in comparison to females (P= < .001 95% CI < -0.0333), The mean age of the patients with secondary osteoporosis was 37.4 (13.5, 18-57) years, with the osteoporosis in 46.4% and osteopenia in 34.1%. In 5 studies of ORF, the incidence of vertebral fractures was between 20%-24%.
  
  
  CONCLUSIONS
  The currently available literature on Saudi Arabian population suggests that the ideal age for screening for low bone mass among the Saudi population should be earlier (55 years) than the >=65 years in Western countries. Both quatitative ultrasound and dual-energy x-ray absorptiometry could be used for screening. The relatively small number of studies on Saudi Arabians and the different machines used for diagnosis limited the authors ability make conclusions with surety.
authors: PO Box 40071 King Fahd University Hospital Al-Khobar 31952 Saudi Arabia. drsadat@hotmail.com
authors: Mir
authors: M
authors: Sadat-Ali
authors: Ibrahim M
authors: IM
authors: Al-Habdan
authors: Haifa A
authors: HA
authors: Al-Turki
authors: Mohammed Quamar
authors: MQ
authors: Azam
mesh_terms: D015994:Incidence; D008403:Mass Screening; D010024:Osteoporosis / Q000453:epidemiology*; D058866:Osteoporotic Fractures / Q000453:epidemiology*; D018570:Risk Assessment / Q000379:methods*; D012529:Saudi Arabia / Q000453:epidemiology
references: Arch Intern Med. 2004 Jul 26;164(14):1525-30
references: 15277283
references: N Engl J Med. 2001 Feb 1;344(5):333-40
references: 11172164
references: Singapore Med J. 2010 Dec;51(12):948-51
references: 21221500
references: J Rheumatol. 2011 Aug;38(8):1671-9
references: 21632675
references: Saudi Med J. 2005 Oct;26(10):1588-90
references: 16228061
references: Lancet. 1996 Dec 7;348(9041):1535-41
references: 8950879
references: Eur Spine J. 2008 Jul;17(7):944-7
references: 18427842
references: Osteoporos Int. 2005 Jan;16(1):43-55
references: 15167986
references: Postgrad Med J. 2007 Aug;83(982):509-17
references: 17675543
references: JAMA. 2001 Dec 12;286(22):2815-22
references: 11735756
references: Saudi Med J. 2006 Nov;27(11):1729-33
references: 17106551
references: Calcif Tissue Int. 1995 Jun;56(6):536-8
references: 7648482
references: N Engl J Med. 2001 May 10;344(19):1434-41
references: 11346808
references: JAMA. 1999 Aug 18;282(7):637-45
references: 10517716
references: World Health Organ Tech Rep Ser. 1994;843:1-129
references: 7941614
references: J Clin Densitom. 2004 Spring;7(1):37-44
references: 14742886
references: Osteoporos Int. 2008 Apr;19(4):399-428
references: 18266020
references: J Bone Miner Res. 1995 Feb;10(2):175-7
references: 7754796
references: West Afr J Med. 2009 May;28(3):169-72
references: 20306733
references: Osteoporos Int. 2003 May;14(3):251-8
references: 12730788
references: Ann Saudi Med. 2009 May-Jun;29(3):215-8
references: 19448373
references: Saudi Med J. 2004 Oct;25(10):1423-7
references: 15494815
references: J Public Health Med. 2001 Mar;23(1):11-7
references: 11315687
references: Saudi Med J. 1999 Apr;20(4):283-6
references: 27614484
references: JAMA. 2009 Oct 14;302(14):1573-9
references: 19826027
references: East Mediterr Health J. 2009 Nov-Dec;15(6):1420-5
references: 20218133
references: J Bone Joint Surg Am. 2000 Aug;82(8):1063-70
references: 10954094
references: J Clin Endocrinol Metab. 2002 Aug;87(8):3609-17
references: 12161484
references: Osteoporos Int. 2001;12(4):311-8
references: 11420781
references: Osteoporos Int. 2004 Mar;15(3):196-203
references: 14735300
references: JAMA. 1999 Oct 13;282(14):1344-52
references: 10527181
references: Ann Intern Med. 2002 Sep 17;137(6):526-8
references: 12230355
references: Saudi Med J. 2007 May;28(5):774-7
references: 17457450
references: J Clin Endocrinol Metab. 1999 Oct;84(10):3431-4
references: 10522975
references: West Afr J Med. 2007 Apr-Jun;26(2):134-7
references: 17939316
references: Indian J Cancer. 2009 Oct-Dec;46(4):331-4
references: 19749464
references: Am J Hematol. 2011 Jun;86(6):506-7
references: 21509795
references: Osteoporos Int. 2006;17(9):1293-302
references: 16810454
references: West Afr J Med. 2008 Oct;27(4):218-23
references: 19469399
references: Calcif Tissue Int. 2007 Dec;81(6):455-8
references: 18066484
references: Saudi Med J. 2009 Nov;30(11):1426-31
references: 19882055
references: Saudi Med J. 2004 Nov;25(11):1623-5
references: 15573189
references: Ann Saudi Med. 2006 Nov-Dec;26(6):450-4
references: 17143021
references: J Bone Miner Res. 1997 Nov;12(11):1761-8
references: 9383679
references: Ann Saudi Med. 1993 May;13(3):272-4
references: 17590676
references: Med J Aust. 2004 Mar 1;180(S5):S18-22
references: 14984358
references: Asian Spine J. 2011 Jun;5(2):107-10
references: 21629485
references: J Clin Densitom. 2006 Oct-Dec;9(4):388-92
references: 17097522
references: Saudi Med J. 2003 Sep;24(9):953-6
references: 12973476
references: Ann Saudi Med. 1996 Jul;16(4):414-6
references: 17372484
references: J Clin Densitom. 2006 Jan-Mar;9(1):15-21
references: 16731427