title: Change of accent as an atypical onset of non fluent primary progressive aphasia.
abstract: Language disorders can be the first symptom of many neurodegenerative diseases, including Alzheimer's disease (AD) and primary progressive aphasia (PPA). The main variants of PPA are: the non-fluent/agrammatic variant, the semantic variant and the logopenic variant.Several additional variants of PPA, however, have been described and are considered as atypical presentations. We describe the case of a woman presenting a progressive isolated language disturbance, characterized by an early dysprosodia, phonological and semantic paraphasias, agrammatism, impairment in repetition, writing of non-words and sentence comprehension. This clinical picture pointed to an atypical presentation of the non-fluent variety. The frequent symptom overlap between the different variants of PPA, most likely reflecting differences in the topography of the pathological changes, needs to be considered in the definition of diagnostic criteria.
authors: Unit of Neurology, Italian National Research Center on Aging, Via della Montagnola, Ancona, Italy. paosusy@yahoo.it
authors: Susy
authors: S
authors: Paolini
authors: Lucia
authors: L
authors: Paciaroni
authors: Antonio
authors: A
authors: Manca
authors: Roberto
authors: R
authors: Rossi
authors: Daniela
authors: D
authors: Fornarelli
authors: Stefano F
authors: SF
authors: Cappa
authors: Angela M
authors: AM
authors: Abbatecola
authors: Osvaldo
authors: O
authors: Scarpino
mesh_terms: D000368:Aged; D032882:Comprehension; D005260:Female; D006801:Humans; D007802:Language; D007806:Language Disorders / Q000175:diagnosis* / Q000503:physiopathology; D009483:Neuropsychological Tests; D057178:Primary Progressive Nonfluent Aphasia / Q000175:diagnosis* / Q000503:physiopathology; D013060:Speech / Q000502:physiology*