title: Profiles of circulating endothelial cells and serum cytokines during adjuvant chemoradiation in rectal cancer patients.
abstract: BACKGROUND
  This research aimed to demonstrate the correlation of circulating endothelial cells (CECs) count and serum cytokine levels with side effects and prognosis in rectal cancer patients receiving adjuvant chemoradiation.
  
  
  METHODS
  Eleven patients received proctectomy, chemoradiotherapy and follow-up for 4 years. Fifty-five blood samples were taken before radiation and during the course. The quantities of CECs were estimated by flow cytometry, and serological factors were measured by ELISA.
  
  
  RESULTS
  The CEC level in patients without tumor recurrence was significantly lower than in patients with tumor recurrence (p < 0.01). The IL-6 and TGF-β1 levels exhibited a similar profile (p < 0.01). For morbidity, the mean CEC level in patients with grade 3 diarrhea was significantly greater than patients with grades 1 (p < 0.001) and 2 diarrhea (p < 0.005).
  
  
  CONCLUSIONS
  Levels of CECs, serum IL-6, TGF-β1 and TNF-α during post-operative chemoradiation in rectal cancer patients might be candidate biomarkers for prognosis and morbidity (NCT00325871).
authors: Division of Gastroenterology, Mackay Memorial Hospital, Taipei, Taiwan.
authors: C-C
authors: CC
authors: Lin
authors: C-Y
authors: CY
authors: Liu
authors: M-J
authors: MJ
authors: Chen
authors: T-E
authors: TE
authors: Wang
authors: C-H
authors: CH
authors: Chu
authors: H-Y
authors: HY
authors: Wang
authors: S-C
authors: SC
authors: Shih
authors: M-L
authors: ML
authors: Hsu
authors: T-C
authors: TC
authors: Hsu
authors: Y-J
authors: YJ
authors: Chen
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology / Q000628:therapy; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D059186:Chemoradiotherapy, Adjuvant; D042783:Endothelial Cells / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000097:blood* / Q000473:pathology / Q000628:therapy; D053773:Transforming Growth Factor beta1 / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; C508600:IL6 protein, human; D015850:Interleukin-6; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
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