title: Fetal brain MRI texture analysis identifies different microstructural patterns in adequate and small for gestational age fetuses at term.
abstract: OBJECTIVE
  We tested the hypothesis whether a texture analysis (TA) algorithm applied to MRI brain images identified different patterns in small for gestational age (SGA) fetuses as compared with adequate for gestational age (AGA).
  
  
  METHODS
  MRI was performed on 83 SGA and 70 AGA at 37 weeks' GA. Texture features were quantified in the frontal lobe, basal ganglia, mesencephalon, cerebellum and cingulum. A classification algorithm based on discriminative models was used to correlate texture features with clinical diagnosis.
  
  
  RESULTS
  Region of interest delineation in all areas was achieved in 61 SGA (12 vasodilated) and 52 AGA; this was the sample for TA feature extraction which allowed classifying SGA from AGA with accuracies ranging from 90.9 to 98.9% in SGA versus AGA comparison and from 93.6 to 100% in vasodilated SGA versus AGA comparison.
  
  
  CONCLUSIONS
  This study demonstrates that TA can detect brain differences in SGA fetuses. This supports the existence of brain microstructural changes in SGA fetuses.
authors: Maternal-Fetal Medicine Department, ICGON, Hospital Clínic, Universitat de Barcelona. msanz1@clinic.ub.es
authors: M
authors: M
authors: Sanz-Cortés
authors: F
authors: F
authors: Figueras
authors: E
authors: E
authors: Bonet-Carne
authors: N
authors: N
authors: Padilla
authors: V
authors: V
authors: Tenorio
authors: N
authors: N
authors: Bargalló
authors: I
authors: I
authors: Amat-Roldan
authors: Eduard
authors: E
authors: Gratacós
mesh_terms: D001921:Brain / Q000098:blood supply / Q000196:embryology* / Q000473:pathology; D055598:Chemical Phenomena; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology / Q000503:physiopathology*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008279:Magnetic Resonance Imaging; D008297:Male; D010927:Placental Insufficiency / Q000503:physiopathology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis / Q000379:methods*; D011446:Prospective Studies; D047929:Term Birth; D014664:Vasodilation