title: To be or not to be a proliferation marker?
abstract: Whether it is nobler in the mind to suffer the slings and arrows of outrageous proliferation, or to take arms against stroma, and favor metastasis… This pastiche of Hamlet's famous monologue illustrates recent reports on the paradoxical functions of well-established proliferation markers such as c-Myc or cyclin A2 that have revealed their ambiguous roles in the control of proliferation and metastasis. On the one hand, overexpression of c-Myc, while stimulating local proliferation, inhibits invasiveness of cancer cells, whereas on the other, downregulation of cyclin A2 leads to increased motility of transformed cells.
authors: 1] Institut de Génétique Moléculaire de Montpellier, CNRS, Montpellier, France [2] Université Montpellier 2, Montpellier, France [3] Université Montpellier 1, Montpellier, France.
authors: J M
authors: JM
authors: Blanchard
mesh_terms: D000818:Animals; D056751:Cyclin A2 / Q000502:physiology*; D006801:Humans; D039482:Integrin alpha5 / Q000378:metabolism*; D039661:Integrin beta3 / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D014158:Transcription, Genetic; D020742:rhoA GTP-Binding Protein / Q000378:metabolism*
chemical_list: D056751:Cyclin A2; D039482:Integrin alpha5; D039661:Integrin beta3; D016271:Proto-Oncogene Proteins c-myc; D020742:rhoA GTP-Binding Protein