title: Insulin-like growth factor-1 and progression of motor symptoms in early, drug-naïve Parkinson's disease.
abstract: Much pre-clinical evidence show that insulin-like growth factor 1 (IGF-1) provides protection against loss of dopaminergic neurons. Recently, IGF-1 has been proposed as a possible biomarker for early diagnosis of Parkinson's disease (PD). We aimed to assess the relationship between serum IGF-1 levels and progression of motor symptoms in a cohort of drug-naïve PD patients. Serum IGF-1 was measured at baseline in 37 early, drug-naive PD patients; subsequently, patients were evaluated "on drug" by means of UPDRS-III, UPDRS dopa-resistant score and dopaminergic score at 12, 18 and 24 month follow-up. Repeated measures ANOVA was used both to evaluate progression of motor scores within time and differences between serum IGF-1 quartiles, age at onset and motor phenotype. Patients at the highest IGF-1 quartile were found to have significantly higher UPDRS-III (p < 0.001) and dopaminergic score (p < 0.001), as compared to patients at other quartiles. Mean serum IGF-1 level was moderately increased in PD as compared to healthy controls (p < 0.011). IGF-1 levels are related to those symptoms predominantly responsive to dopaminergic treatment. This is the first study to demonstrate a relationship between serum IGF-1 and progression of motor symptoms in the early stage of disease.
authors: Department of Neurological Sciences, Federico II University, Naples, Italy.
authors: Marina
authors: M
authors: Picillo
authors: Roberto
authors: R
authors: Erro
authors: Gabriella
authors: G
authors: Santangelo
authors: Rosario
authors: R
authors: Pivonello
authors: Katia
authors: K
authors: Longo
authors: Claudia
authors: C
authors: Pivonello
authors: Carmine
authors: C
authors: Vitale
authors: Marianna
authors: M
authors: Amboni
authors: Marcello
authors: M
authors: Moccia
authors: Annamaria
authors: A
authors: Colao
authors: Paolo
authors: P
authors: Barone
authors: Maria Teresa
authors: MT
authors: Pellecchia
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I
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