title: Comparison of the efficacy of ondansetron and granisetron to prevent postoperative nausea and vomiting after laparoscopic cholecystectomy:  a systematic review and meta-analysis.
abstract: OBJECTIVE
  Our purpose was to assess the prophylactic antiemetic effects of ondansetron versus granisetron for laparoscopic cholecystectomy.
  
  
  METHODS
  We searched Medline, Cochrane Central Register of Controlled Trials, PubMed, Embase, Science Citation Index Expanded, Foreign Medical Journal Full-Text Service, China National Knowledge Infrastructure Whole Article Database, Chinese Biomedical Database, and the Google Scholar. We calculated the risk ratio (RR) with 95% confidence interval (CI) for dichotomous data. The χ(2) test and I(2) value were used to assess heterogeneity.
  
  
  RESULTS
  The merged early incidence of postoperative nausea and vomiting (PONV) in ondansetron group (42.9%) was higher than granisetron group (34.3%) (RR = 1.25, 95% CI, 0.82-1.92, P=0.31, I(2) = 48%). The merged total incidence of PONV in ondansetron group (38.7%) was higher than granisetron group (34.2%) (RR = 1.13, 95% CI, 0.82-1.56, P = 0.46, I(2) = 39%), although these differences were not statistically significant.
  
  
  CONCLUSIONS
  Ondansetron is equivalent to granisetron for preventing early and total incidence of PONV after laparoscopic cholecystectomy.
authors: Department of Bile Duct Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Si-Jia
authors: SJ
authors: Wu
authors: Xian-Ze
authors: XZ
authors: Xiong
authors: Yi-Xin
authors: YX
authors: Lin
authors: Nan-Sheng
authors: NS
authors: Cheng
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D017829:Granisetron / Q000627:therapeutic use*; D020773:Headache Disorders / Q000139:chemically induced; D006801:Humans; D017294:Ondansetron / Q000627:therapeutic use*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D018401:Sample Size; D016896:Treatment Outcome
chemical_list: D000932:Antiemetics; D017829:Granisetron; D017294:Ondansetron