title: Hepatitis C virus in pregnancy.
abstract: Despite recent advances in the pathogenesis, treatment, and public health response to hepatitis C virus (HCV), HCV as it specifically relates to pregnancy has been a neglected condition. HCV-monoinfected pregnant women have a 2-8% risk of viral transmission to their infant, but the mechanism and timing of mother to child transmission (MTCT) are not fully understood, nor is the natural history of the illness in pregnant women and their offspring. Recognition of HCV-infected pregnant women is relevant because of the long-term health implications for the mother, potential adverse effects of infection on pregnancy outcomes, and the possibility of transmission to their infants. Certain risk factors for MTCT of HCV appear similar to those for human immunodeficiency virus (HIV); however, unlike HIV, effective methods for prevention of HCV vertical transmission have not been developed. It is possible that a better understanding of HCV MTCT and pathogenesis in pregnancy will guide development of useful prevention strategies, particularly as we enter an era where interferon-free drug cocktails may emerge as viable treatment options for HCV.
authors: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wexner Medical Center, The Ohio State University College of Medicine, Columbus, OH 43210, USA. mona.prasad@osumc.edu
authors: Mona R
authors: MR
authors: Prasad
authors: Jonathan R
authors: JR
authors: Honegger
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D006526:Hepatitis C / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008403:Mass Screening; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D011256:Pregnancy Outcome; D012307:Risk Factors
chemical_list: D000998:Antiviral Agents
references: J Hepatol. 2000 Feb;32(2):293-9
references: 10707870
references: Can J Public Health. 2011 Mar-Apr;102(2):98-102
references: 21608379
references: Hepatology. 2002 Nov;36(5 Suppl 1):S21-9
references: 12407573
references: Pediatrics. 1998 Aug;102(2 Pt 1):355-9
references: 9685438
references: J Gen Intern Med. 2002 Feb;17(2):134-43
references: 11841529
references: J Infect Dis. 2005 Dec 1;192(11):1872-9
references: 16267757
references: Clin Infect Dis. 1997 Nov;25(5):1121-4
references: 9402369
references: MMWR Morb Mortal Wkly Rep. 2012 May 18;61(19):358
references: 22592276
references: Acta Obstet Gynecol Scand. 2000 Jul;79(7):543-7
references: 10929952
references: J Pediatr. 1998 Jan;132(1):167-9
references: 9470023
references: J Infect Dis. 2011 Jan 15;203(2):196-206
references: 21288819
references: J Med Virol. 2008 Jan;80(1):65-71
references: 18041020
references: Science. 2004 Aug 6;305(5685):872-4
references: 15297676
references: N Engl J Med. 2001 Jul 5;345(1):41-52
references: 11439948
references: BMJ. 1998 Aug 15;317(7156):437-41
references: 9703524
references: J Med Virol. 2006 Jul;78(7):911-4
references: 16721858
references: BMJ. 1997 Aug 9;315(7104):333-7
references: 9270453
references: Am J Public Health. 2005 Oct;95(10):1739-40
references: 16186452
references: Int J Epidemiol. 1998 Feb;27(1):108-17
references: 9563703
references: Reprod Toxicol. 2012 Jun;33(3):265-8
references: 22200624
references: Clin Infect Dis. 2005 Jul 15;41(2):177-86
references: 15983913
references: Br J Obstet Gynaecol. 1999 May;106(5):498-500
references: 10430202
references: Clin Infect Dis. 2007 Apr 15;44(8):1123-31
references: 17366462
references: Hepatology. 2011 Jun;53(6):1830-8
references: 21413051
references: Nature. 2009 Sep 17;461(7262):399-401
references: 19684573
references: J Hepatol. 1998 Aug;29(2):191-7
references: 9722199
references: Virology. 2009 Jul 20;390(1):64-70
references: 19481774
references: Obstet Gynecol. 2007 Oct;110(4):941-56
references: 17906043
references: Rev Saude Publica. 2011 Oct;45(5):974-6
references: 21829975
references: World J Gastroenterol. 2006 Aug 7;12(29):4757-60
references: 16937453
references: MMWR Morb Mortal Wkly Rep. 2011 Oct 28;60(42):1457-8
references: 22031220
references: J Hepatol. 2008 Nov;49(5):831-44
references: 18814931
references: J Viral Hepat. 2012 Jul;19(7):449-64
references: 22676357
references: Acta Obstet Gynecol Scand. 2002 Feb;81(2):99-103
references: 11942897
references: Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):369-78
references: 16831303
references: Gastroenterol Clin Biol. 2006 May;30(5):786-9
references: 16801905
references: N Engl J Med. 1992 Dec 31;327(27):1899-905
references: 1280771
references: J Womens Health (Larchmt). 2012 Jan;21(1):66-72
references: 22011209
references: J Infect Dis. 2005 Jul 15;192(2):258-65
references: 15962220
references: Acta Obstet Gynecol Scand. 1998 Oct;77(9):889-92
references: 9808375
references: Gastroenterology. 2010 Feb;138(2):513-21, 521.e1-6
references: 19861128
references: Pediatr Infect Dis J. 2011 Jul;30(7):618-20
references: 21394051
references: Am J Obstet Gynecol. 2005 Apr;192(4):1153-61
references: 15846195
references: Obstet Gynecol Surv. 2006 Oct;61(10):666-72
references: 16978426
references: BJOG. 2001 Apr;108(4):371-7
references: 11305543
references: MMWR Recomm Rep. 1998 Oct 16;47(RR-19):1-39
references: 9790221
references: J Viral Hepat. 1997;4(6):395-409
references: 9430360
references: Hepatology. 2011 Oct;54(4):1433-44
references: 21898493
references: J Med Virol. 2002 Jun;67(2):137-42
references: 11992574
references: J Med Virol. 2009 May;81(5):836-43
references: 19319981
references: Scand J Infect Dis. 1998;30(2):111-3
references: 9730293
references: Hepatology. 2009 Apr;49(4):1335-74
references: 19330875
references: Scand J Infect Dis. 1996;28(4):353-6
references: 8893397
references: J Pediatr. 2013 Jan;162(1):148-54
references: 22883419
references: Viruses. 2012 Dec 06;4(12):3531-50
references: 23223189
references: Hepatology. 2010 Mar;51(3):729-33
references: 20186842
references: Birth Defects Res A Clin Mol Teratol. 2010 Jul;88(7):551-9
references: 20564430
references: Liver Int. 2011 Sep;31(8):1163-70
references: 21745298
references: Pediatr Res. 2002 Jun;51(6):746-9
references: 12032271
references: J Med Virol. 2012 Oct;84(10):1586-92
references: 22930506
references: Hepatology. 2001 Aug;34(2):223-9
references: 11481604
references: MMWR Recomm Rep. 2012 Aug 17;61(RR-4):1-32
references: 22895429
references: Blood. 2000 Sep 15;96(6):2045-8
references: 10979945
references: J Pediatr. 2012 Nov;161(5):915-21
references: 22765955
references: Arch Dis Child Fetal Neonatal Ed. 2005 Mar;90(2):F156-60
references: 15724041
references: J Hepatol. 2005 Sep;43(3):394-402
references: 16023248
references: J Clin Invest. 2009 Jul;119(7):1745-54
references: 19587449
references: Nature. 2009 Oct 8;461(7265):798-801
references: 19759533
references: Obstet Gynecol. 2008 Aug;112(2 Pt 1):304-10
references: 18669727
references: J Pediatr. 1995 Apr;126(4):589-91
references: 7535353
references: Pediatr Infect Dis J. 1995 Mar;14(3):195-9
references: 7761184
references: J Infect Dis. 2005 Dec 1;192(11):1880-9
references: 16267758
references: J Viral Hepat. 2011 Apr;18(4):229-36
references: 21392169
references: Obstet Gynecol. 1992 Oct;80(4):609-13
references: 1407881
references: N Engl J Med. 1994 Mar 17;330(11):744-50
references: 8107740
references: BJOG. 2000 Dec;107(12):1503-6
references: 11192107
references: J Med Virol. 2003 Sep;71(1):56-61
references: 12858409
references: J Hepatol. 1999 Sep;31(3):416-20
references: 10488698
references: Ann Intern Med. 2006 May 16;144(10):705-14
references: 16702586
references: Gut. 2000 Aug;47(2):277-80
references: 10896922
references: Am J Obstet Gynecol. 1993 Sep;169(3):583-7
references: 7690523
references: Lancet. 1995 Feb 4;345(8945):289-91
references: 7530793
references: J Infect Dis. 2011 Mar 15;203(6):854-61
references: 21257736
references: J Infect Dis. 2002 Mar 1;185(5):567-72
references: 11865412
references: Hepatology. 2000 Mar;31(3):751-5
references: 10706568
references: J Viral Hepat. 2011 Jul;18(7):e394-8
references: 21692952
references: Br J Obstet Gynaecol. 1996 Apr;103(4):325-9
references: 8605128
references: Am J Obstet Gynecol. 2008 Jul;199(1):38.e1-9
references: 18486089
references: Lancet Infect Dis. 2005 Sep;5(9):558-67
references: 16122679
references: Lancet. 2000 Sep 9;356(9233):904-7
references: 11036896
references: Acta Obstet Gynecol Scand. 2003 Mar;82(3):229-34
references: 12694118
references: Am J Obstet Gynecol. 2004 Sep;191(3):998-1003
references: 15467579
references: J Med Virol. 2003 Oct;71(2):205-11
references: 12938194
references: Hepatology. 2002 Nov;36(5 Suppl 1):S106-13
references: 12407583
references: J Infect Dis. 2003 Feb 1;187(3):345-51
references: 12552417
references: Aust N Z J Obstet Gynaecol. 2003 Aug;43(4):290-3
references: 14714713
references: Int J Immunopathol Pharmacol. 2007 Oct-Dec;20(4):827-31
references: 18179755
references: PLoS One. 2010 Aug 30;5(8):e12232
references: 20814429
references: Am J Gastroenterol. 2001 Sep;96(9):2751-4
references: 11569706
references: Hepatology. 2001 May;33(5):1341-2
references: 11343269
references: J Clin Virol. 2007 Feb;38(2):91-5
references: 17210267
references: Ann Intern Med. 2013 Jan 15;158(2):109-13
references: 23437438
references: Cochrane Database Syst Rev. 2006 Oct 18;(4):CD005546
references: 17054264