title: Risk-based indicators of Canadians' exposures to environmental carcinogens.
abstract: BACKGROUND
  Tools for estimating population exposures to environmental carcinogens are required to support evidence-based policies to reduce chronic exposures and associated cancers. Our objective was to develop indicators of population exposure to selected environmental carcinogens that can be easily updated over time, and allow comparisons and prioritization between different carcinogens and exposure pathways.
  
  
  METHODS
  We employed a risk assessment-based approach to produce screening-level estimates of lifetime excess cancer risk for selected substances listed as known carcinogens by the International Agency for Research on Cancer. Estimates of lifetime average daily intake were calculated using population characteristics combined with concentrations (circa 2006) in outdoor air, indoor air, dust, drinking water, and food and beverages from existing monitoring databases or comprehensive literature reviews. Intake estimates were then multiplied by cancer potency factors from Health Canada, the United States Environmental Protection Agency, and the California Office of Environmental Health Hazard Assessment to estimate lifetime excess cancer risks associated with each substance and exposure pathway. Lifetime excess cancer risks in excess of 1 per million people are identified as potential priorities for further attention.
  
  
  RESULTS
  Based on data representing average conditions circa 2006, a total of 18 carcinogen-exposure pathways had potential lifetime excess cancer risks greater than 1 per million, based on varying data quality. Carcinogens with moderate to high data quality and lifetime excess cancer risk greater than 1 per million included benzene, 1,3-butadiene and radon in outdoor air; benzene and radon in indoor air; and arsenic and hexavalent chromium in drinking water. Important data gaps were identified for asbestos, hexavalent chromium and diesel exhaust in outdoor and indoor air, while little data were available to assess risk for substances in dust, food and beverages.
  
  
  CONCLUSIONS
  The ability to track changes in potential population exposures to environmental carcinogens over time, as well as to compare between different substances and exposure pathways, is necessary to support comprehensive, evidence-based prevention policy. We used estimates of lifetime excess cancer risk as indicators that, although based on a number of simplifying assumptions, help to identify important data gaps and prioritize more detailed data collection and exposure assessment needs.
authors: Department of Geography, University of Victoria, Victoria, BC, Canada. elsetton@uvic.ca
authors: Eleanor
authors: E
authors: Setton
authors: Perry
authors: P
authors: Hystad
authors: Karla
authors: K
authors: Poplawski
authors: Roslyn
authors: R
authors: Cheasley
authors: Alejandro
authors: A
authors: Cervantes-Larios
authors: C Peter
authors: CP
authors: Keller
authors: Paul A
authors: PA
authors: Demers
mesh_terms: D002170:Canada / Q000453:epidemiology; D002274:Carcinogens, Environmental / Q000032:analysis*; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D008962:Models, Theoretical; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D018570:Risk Assessment
chemical_list: D002274:Carcinogens, Environmental
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