title: Identifying the perfusion deficit in acute stroke with resting-state functional magnetic resonance imaging.
abstract: Temporal delay in blood oxygenation level-dependent (BOLD) signals may be sensitive to perfusion deficits in acute stroke. Resting-state functional magnetic resonance imaging (rsfMRI) was added to a standard stroke MRI protocol. We calculated the time delay between the BOLD signal at each voxel and the whole-brain signal using time-lagged correlation and compared the results to mean transit time derived using bolus tracking. In all 11 patients, areas exhibiting significant delay in BOLD signal corresponded to areas of hypoperfusion identified by contrast-based perfusion MRI. Time delay analysis of rsfMRI provides information comparable to that of conventional perfusion MRI without the need for contrast agents.
authors: Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors: Yating
authors: Y
authors: Lv
authors: Daniel S
authors: DS
authors: Margulies
authors: R
authors: R
authors: Cameron Craddock
authors: Xiangyu
authors: X
authors: Long
authors: Benjamin
authors: B
authors: Winter
authors: Daniel
authors: D
authors: Gierhake
authors: Matthias
authors: M
authors: Endres
authors: Kersten
authors: K
authors: Villringer
authors: Jochen
authors: J
authors: Fiebach
authors: Arno
authors: A
authors: Villringer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012146:Rest / Q000502:physiology*; D020521:Stroke / Q000175:diagnosis* / Q000503:physiopathology*