title: Adverse effects associated with high-dose acetylsalicylic acid and sodium salicylate treatment in broilers.
abstract: 1. Acetylsalicylic acid (ASA) and sodium salicylate (SS) are considered safe for poultry and often used in avian medicine. However, information on tolerance and specific side effects of these drugs in birds is lacking.   2. The aim of this study was to determine the effects of 14 d administration of high doses (200 or 400 mg/kg) of either ASA or SS on body weight gain, blood biochemistry, white and red blood cell counts and pathology in broilers. In addition, minimal plasma salicylate concentrations were determined on the 1st, 5th, 10th and 14th d of treatment.   3. The results showed that the dose of 400 mg/kg of either ASA or SS decreased weight gain and induced gizzard ulceration. Kidney to body weight ratio was increased in a dose-dependent manner, but serum concentrations of creatinine and uric acid were not affected. A time-dependent decrease in the minimal plasma salicylate concentration was evident.
authors: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wrocław, Poland. blazej.pozniak@up.wroc.pl
authors: B
authors: B
authors: Poźniak
authors: M
authors: M
authors: Switała
authors: K
authors: K
authors: Bobrek
authors: S
authors: S
authors: Graczyk
authors: S
authors: S
authors: Dzimira
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000097:blood; D001241:Aspirin / Q000008:administration & dosage* / Q000097:blood; D001774:Blood Chemical Analysis / Q000662:veterinary; D002645:Chickens / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000473:pathology; D006403:Hematologic Tests / Q000662:veterinary; D009929:Organ Size / Q000187:drug effects; D012980:Sodium Salicylate / Q000008:administration & dosage* / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D012980:Sodium Salicylate