title: Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara.
abstract: From an endophytic fungus, a close relative of Talaromyces sp., found in association with Cedrus deodara, four compounds including two new ones (2 and 4) were isolated and characterized. The structures of two compounds (1 and 4) were confirmed by X-ray crystallography. The compounds displayed a range of cytotoxicities against human cancer cell lines (HCT-116, A-549, HEP-1, THP-1, and PC-3). All the compounds were found to induce apoptosis in HL-60 cells, as evidenced by fluorescence and scanning electron microscopy studies. Also, the compounds caused significant microtubule inhibition in HL-60 cells.
authors: Natural Product Microbes, Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, India.
authors: Manjeet
authors: M
authors: Kumar
authors: Masroor
authors: M
authors: Qadri
authors: Parduman Raj
authors: PR
authors: Sharma
authors: Arvind
authors: A
authors: Kumar
authors: Samar S
authors: SS
authors: Andotra
authors: Tandeep
authors: T
authors: Kaur
authors: Kamini
authors: K
authors: Kapoor
authors: Vivek K
authors: VK
authors: Gupta
authors: Rajni
authors: R
authors: Kant
authors: Abid
authors: A
authors: Hamid
authors: Sarojini
authors: S
authors: Johri
authors: Subhash C
authors: SC
authors: Taneja
authors: Ram A
authors: RA
authors: Vishwakarma
authors: Syed
authors: S
authors: Riyaz-Ul-Hassan
authors: Bhahwal Ali
authors: BA
authors: Shah
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001203:Ascomycota / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028203:Cedrus / Q000382:microbiology*; D018360:Crystallography, X-Ray; D045325:HCT116 Cells; D018922:HL-60 Cells; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008968:Molecular Conformation; D015394:Molecular Structure; D050257:Tubulin Modulators / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C579827:(1S*,3R*,5R*)-3-methyl-2-oxa-bicyclo(3.3.1)nonan-7-one; C579826:(3S,4aR,7S)-7,8-dihydroxy-3-methyl-3,4,10,5,6,7-hexahydro-1H-isochromen-1-one; D019086:Bridged Bicyclo Compounds, Heterocyclic; D049934:Isocoumarins; D050257:Tubulin Modulators