title: TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease.
abstract: The rs75932628-T variant of the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has recently been identified as a rare risk factor for late-onset Alzheimer's disease (AD). In this study we examined the association between TREM2 exon 2 variants and early-onset AD in a sample of Caucasian subjects of French origin including 726 patients with age of onset ≤65 years and 783 controls. Only the rs75932628-T variant (predicted to cause an R47H substitution) conferred a significant risk for early-onset AD (OR, 4.07; 95% CI, 1.3 to 16.9; p = 0.009). These results confirm the association between this variant and AD and underline its involvement in early-onset cases.
authors: INSERM U1079, Faculté de Médecine, IRIB, Rouen, France.
authors: Cyril
authors: C
authors: Pottier
authors: David
authors: D
authors: Wallon
authors: Stephane
authors: S
authors: Rousseau
authors: Anne
authors: A
authors: Rovelet-Lecrux
authors: Anne-Claire
authors: AC
authors: Richard
authors: Adeline
authors: A
authors: Rollin-Sillaire
authors: Thierry
authors: T
authors: Frebourg
authors: Dominique
authors: D
authors: Campion
authors: Didier
authors: D
authors: Hannequin
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C498715:TREM2 protein, human