title: Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis).
abstract: Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores the possibility that sleep-disordered breathing (SDB) and associated oxidative stress contribute to the etiology of CMS. Nocturnal respiratory and [Formula: see text] patterns were measured using standard polysomnography techniques and compared between male high-altitude residents (aged 18-25) with preclinical CMS (excessive erythrocytosis (EE), n=20) and controls (n=19). Measures of oxidative stress and antioxidant status included isoprostanes (8-iso-PGF2alpha), superoxide dismutase and ascorbic acid. EE cases had a greater apnea-hypopnea index, a higher frequency of apneas (central and obstructive) and hypopneas during REM sleep, and lower nocturnal [Formula: see text] compared to controls. 8-iso-PGF2alpha was greater in EE than controls, negatively associated with nocturnal [Formula: see text] , and positively associated with hemoglobin concentration. Mild sleep-disordered breathing and oxidative stress are evident in preclinical CMS, suggesting that the resolution of nocturnal hypoxemia or antioxidant treatment may prevent disease progression.
authors: Altitude Research Center, Department of Emergency Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA. colleen.julian@ucdenver.edu
authors: Colleen Glyde
authors: CG
authors: Julian
authors: Enrique
authors: E
authors: Vargas
authors: Marcelino
authors: M
authors: Gonzales
authors: R Daniela
authors: RD
authors: Dávila
authors: Anne
authors: A
authors: Ladenburger
authors: Lindsay
authors: L
authors: Reardon
authors: Caroline
authors: C
authors: Schoo
authors: Robert W
authors: RW
authors: Powers
authors: Teofilo
authors: T
authors: Lee-Chiong
authors: Lorna G
authors: LG
authors: Moore
mesh_terms: D000293:Adolescent; D000328:Adult; D000532:Altitude Sickness / Q000150:complications* / Q000503:physiopathology; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D011086:Polycythemia / Q000209:etiology; D017286:Polysomnography; D012129:Respiratory Function Tests; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000503:physiopathology; D055815:Young Adult
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