title: Association of KIR genes and HLA-C alleles with HPV-related uterine cervical disease in Korean women.
abstract: This study investigated whether killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles, receptors and ligands of natural killer cells are associated with the development of human papillomavirus (HPV)-related cervical disease in Korean women. Blood samples from 132 women with HPV-related cervical disease and 159 women without HPV infection were collected for genotyping of KIR genes and HLA-C alleles. Although no relationship was found between KIR genes and HPV-related cervical disease, a significant relationship was found between HLA-C alleles as ligands of KIR and HPV-related cervical disease. Women with HPV-related cervical disease were found to be significantly more likely to carry HLA-C*0303, particularly those with HPV 16 or 18 infection, and less likely to carry HLA-C*01 compared to women without HPV infection. HLA-C*0303 was found to confer susceptibility to HPV-related cervical disease, whereas HLA-C*01 was found to confer a protective effect against HPV-related cervical disease.
authors: Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, South Korea.
authors: M J
authors: MJ
authors: Song
authors: C W
authors: CW
authors: Lee
authors: J H
authors: JH
authors: Kim
authors: S J
authors: SJ
authors: Lee
authors: C J
authors: CJ
authors: Kim
authors: S Y
authors: SY
authors: Hur
authors: T C
authors: TC
authors: Park
authors: T G
authors: TG
authors: Kim
authors: J S
authors: JS
authors: Park
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000235:genetics* / Q000276:immunology; D054340:Receptors, KIR / Q000235:genetics*; D056910:Republic of Korea; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000276:immunology / Q000821:virology; D055815:Young Adult
chemical_list: D015236:HLA-C Antigens; D054340:Receptors, KIR