title: The role of hepatocyte-specific contrast agents in hepatobiliary magnetic resonance imaging.
abstract: Hepatocyte-specific contrast agents have been made available in the last 15 years for magnetic resonance imaging of the liver. These agents are differentially taken up by functioning hepatocytes and excreted in the biliary system. They can help distinguish focal liver lesions of hepatocellular origin from lesions of nonhepatocellular origin, and can also be used in the evaluation of the biliary tree. The purpose of this review is to summarize the different types of hepatocyte-specific contrast agents presently available, their use in the characterization of focal liver lesions, their role in the evaluation of biliary pathology, and their potential future applications.
authors: Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, UK.
authors: Chistopher
authors: C
authors: Burke
authors: Lee
authors: L
authors: Alexander Grant
authors: Vicky
authors: V
authors: Goh
authors: Nyree
authors: N
authors: Griffin
mesh_terms: D001650:Bile Duct Neoplasms / Q000175:diagnosis*; D001652:Bile Ducts / Q000473:pathology; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives; D019786:Gadolinium DTPA; D022781:Hepatocytes; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008536:Meglumine / Q000031:analogs & derivatives; D009942:Organometallic Compounds; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C073590:gadolinium ethoxybenzyl DTPA; C064572:gadobenic acid; D011732:Pyridoxal Phosphate; D008536:Meglumine; D004492:Edetic Acid; D019786:Gadolinium DTPA; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid