title: The human gut microbiome and body metabolism: implications for obesity and diabetes.
abstract: BACKGROUND
  Obesity, metabolic syndrome, and type 2 diabetes are major public health challenges. Recently, interest has surged regarding the possible role of the intestinal microbiota as potential novel contributors to the increased prevalence of these 3 disorders.
  
  
  BACKGROUND
  Recent advances in microbial DNA sequencing technologies have resulted in the widespread application of whole-genome sequencing technologies for metagenomic DNA analysis of complex ecosystems such as the human gut. Current evidence suggests that the gut microbiota affect nutrient acquisition, energy harvest, and a myriad of host metabolic pathways.
  
  
  CONCLUSIONS
  Advances in the Human Microbiome Project and human metagenomics research will lead the way toward a greater understanding of the importance and role of the gut microbiome in metabolic disorders such as obesity, metabolic syndrome, and diabetes.
authors: Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
authors: Sridevi
authors: S
authors: Devaraj
authors: Peera
authors: P
authors: Hemarajata
authors: James
authors: J
authors: Versalovic
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism; D003920:Diabetes Mellitus / Q000378:metabolism / Q000382:microbiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D054892:Metagenome; D009765:Obesity / Q000382:microbiology*
chemical_list: D000596:Amino Acids
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