title: [Generation of superoxide anion-radical in the liver monooxygenase system of preliminary radiation-exposed tumor-bearing rats].
abstract: Generation of superoxide anion-radical (O2*-) in reductase and oxygenase electron-transport chains in the liver monooxygenase system was investigated in tumor-bearing rats exposed to preliminary irradiation. Preliminary irradiation of rats (before transplantation of Guerin's carcinoma) resulted in the increased generation of superoxide anion-radical by components of the liver monooxygenase system in the logarithmic phase of oncogenesis. It is shown that the increased NADPH-cytochrome P-450 reductase activity is accompanied with the intensification of superoxide anion-radical generation in liver microsomal fraction of preliminary radiation-exposed rats. At the same time the cytochrome P-450 hydroxylase activity in the microsomal fraction of tumor-bearing rats subjected to preliminary irradiation was decreased.
authors: M M
authors: MM
authors: Marchenko
authors: O V
authors: OV
authors: Ketsa
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D002277:Carcinoma / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000528:radiation effects*; D015536:Down-Regulation; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects; D007279:Injections, Subcutaneous; D008099:Liver / Q000378:metabolism* / Q000528:radiation effects; D008862:Microsomes, Liver / Q000378:metabolism* / Q000528:radiation effects; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D009368:Neoplasm Transplantation; D011829:Radiation Dosage; D051381:Rats; D013481:Superoxides / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D013481:Superoxides; D006899:Mixed Function Oxygenases; D009251:NADPH-Ferrihemoprotein Reductase