title: Finding the sources of missing heritability in a yeast cross.
abstract: For many traits, including susceptibility to common diseases in humans, causal loci uncovered by genetic-mapping studies explain only a minority of the heritable contribution to trait variation. Multiple explanations for this 'missing heritability' have been proposed. Here we use a large cross between two yeast strains to accurately estimate different sources of heritable variation for 46 quantitative traits, and to detect underlying loci with high statistical power. We find that the detected loci explain nearly the entire additive contribution to heritable variation for the traits studied. We also show that the contribution to heritability of gene-gene interactions varies among traits, from near zero to approximately 50 per cent. Detected two-locus interactions explain only a minority of this contribution. These results substantially advance our understanding of the missing heritability problem and have important implications for future studies of complex and quantitative traits.
authors: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA.
authors: Joshua S
authors: JS
authors: Bloom
authors: Ian M
authors: IM
authors: Ehrenreich
authors: Wesley T
authors: WT
authors: Loo
authors: Thúy-Lan Võ
authors: TL
authors: Lite
authors: Leonid
authors: L
authors: Kruglyak
mesh_terms: D003433:Crosses, Genetic; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000502:physiology
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