title: Efficacy in reducing dentine hypersensitivity of a regimen using a toothpaste containing 8% arginine and calcium carbonate, a mouthwash containing 0.8% arginine, pyrophosphate and PVM/MA copolymer and a toothbrush compared to potassium and negative control regimens: an eight-week randomized clinical trial.
abstract: OBJECTIVE
  Evaluate the efficacy of three regimens integrating toothpaste, toothbrush and mouthwash in reducing dentine hypersensitivity.
  
  
  METHODS
  Eight-week single-centre, three-cell, double-blind, randomized study was conducted in the Dominican Republic. Subjects entered one of the three regimens: (1) toothpaste containing 8% arginine and 1450 ppm mono-fluorophosphate, in a calcium carbonate base, a soft-bristle toothbrush followed by a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride; (2) toothpaste containing 5% potassium nitrate and 1450 ppm sodium fluoride, a soft-bristle toothbrush, followed by a mouthwash containing 0.51% potassium chloride and 230 ppm sodium fluoride; and (3) toothpaste containing 1450 ppm mono-fluorophosphate, a soft-bristle toothbrush followed by a fluoride/arginine free mouthwash. Tactile and Air-Blast dentine hypersensitivity measurements were performed at baseline, two, four, and eight weeks. For treatment group comparisons, ANCOVA and post hoc Tukey's pair-wise (α=0.05) were used. Kaplan-Meier survival analysis was performed to evaluate Time to Treatment Improvement.
  
  
  RESULTS
  120 subjects were enrolled, 118 completed the study. The Tactile hypersensitivity mean scores showed statistically significant improvement at two, four and eight (p ≤ 0.001) weeks in the arginine regime; the potassium regime did not show significant (p ≥ 0.05) improvement. Air-Blast Hypersensitivity scores had a statistically significant decrease at two (p=0.006), four (p=0.006) and eight (p=0.002) weeks in arginine and potassium regimes (p ≤ 0.05). The most effective treatment proved to be arginine (p ≤ 0.05) compared to the potassium regime.
  
  
  CONCLUSIONS
  Arginine regimen provided the greatest reduction in Tactile and Air-Blast dentine hypersensitivity compared to potassium and negative control regimens; and provides faster dentine hypersensitivity relief than potassium regimen.
authors: University of Puerto Rico, School of Dental Medicine, San Juan, Puerto Rico, USA. Augusto.Elias@upr.edu
authors: Augusto R
authors: AR
authors: Elias Boneta
authors: Karol
authors: K
authors: Ramirez
authors: Joselyn
authors: J
authors: Naboa
authors: Luis R
authors: LR
authors: Mateo
authors: Bernal
authors: B
authors: Stewart
authors: Foti
authors: F
authors: Panagokos
authors: William
authors: W
authors: De Vizio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000388:Air; D000704:Analysis of Variance; D001120:Arginine / Q000737:chemistry / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000737:chemistry / Q000627:therapeutic use*; D057133:Dentin Desensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D011756:Diphosphates / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D008875:Middle Aged; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D010710:Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D011095:Polyethylenes / Q000627:therapeutic use*; D011188:Potassium / Q000627:therapeutic use; D011446:Prospective Studies; D012969:Sodium Fluoride / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D013997:Time Factors; D014099:Toothbrushing / Q000295:instrumentation; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*; D014110:Touch; D055815:Young Adult
chemical_list: D057133:Dentin Desensitizing Agents; D011756:Diphosphates; D004338:Drug Combinations; D008298:Maleates; D009067:Mouthwashes; D010710:Phosphates; D011095:Polyethylenes; D014100:Toothpastes; C585805:pro-argin; C012980:fluorophosphate; C107241:diphosphoric acid; D012969:Sodium Fluoride; C043105:poly(methyl vinyl ether-co-maleic anhydride); D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides; D011188:Potassium