title: Differential loss of invariant natural killer T cells and FoxP3⁺ regulatory T cells in HIV-1 subtype A and subtype D infections.
abstract: HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3⁺ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.
authors: Makerere University Walter Reed Project, Kampala, Uganda.
authors: Britta
authors: B
authors: Flach
authors: Prossy
authors: P
authors: Naluyima
authors: Kim
authors: K
authors: Blom
authors: Veronica D
authors: VD
authors: Gonzalez
authors: Leigh Anne
authors: LA
authors: Eller
authors: Oliver
authors: O
authors: Laeyendecker
authors: Thomas C
authors: TC
authors: Quinn
authors: David
authors: D
authors: Serwadda
authors: Nelson K
authors: NK
authors: Sewankambo
authors: Maria J
authors: MJ
authors: Wawer
authors: Ronald H
authors: RH
authors: Gray
authors: Nelson L
authors: NL
authors: Michael
authors: Fred
authors: F
authors: Wabwire-Mangen
authors: Merlin L
authors: ML
authors: Robb
authors: Michael A
authors: MA
authors: Eller
authors: Johan K
authors: JK
authors: Sandberg
mesh_terms: D056704:Adaptive Immunity; D000293:Adolescent; D000328:Adult; D055610:Antigens, CD1d / Q000096:biosynthesis; D015704:CD4 Antigens / Q000378:metabolism; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D055611:Natural Killer T-Cells / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D055815:Young Adult
chemical_list: D055610:Antigens, CD1d; C526877:CD1D protein, human; D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D007376:Interleukin-2
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