title: Pd-catalyzed asymmetric allylic alkylations of 3-substituted indoles using chiral P/olefin ligands.
abstract: A palladium-catalyzed asymmetric allylic alkylation of 3-substituted indoles using P/olefin ligands was successfully achieved to afford a variety of indolenines containing a quaternary carbon stereocenter in high yields with up to 87% ee. Significantly, this reaction provides a concise access to a stereoisomer of the natural product Angelicastigmin.
authors: Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors: Yilin
authors: Y
authors: Liu
authors: Haifeng
authors: H
authors: Du
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D007211:Indoles; D010165:Palladium