title: Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris.
abstract: A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using a combination of spectroscopic and chemical methods, including HRMS, extensive 1D and 2D NMR analysis, MS/MS fragmentation, and chemical degradation and Marfey's analysis of the resulting amino acid residues. The structure herein reported corrects that previously assigned to PM181104 (3). Kocurin displayed activity against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values in the submicromolar range.
authors: Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda del Conocimiento 3, Granada 18016, Spain. jesus.martin@medinaandalucia.es
authors: Jesús
authors: J
authors: Martín
authors: Thiciana
authors: T
authors: da S Sousa
authors: Gloria
authors: G
authors: Crespo
authors: Sara
authors: S
authors: Palomo
authors: Ignacio
authors: I
authors: González
authors: José R
authors: JR
authors: Tormo
authors: Mercedes
authors: M
authors: de la Cruz
authors: Matthew
authors: M
authors: Anderson
authors: Russell T
authors: RT
authors: Hill
authors: Francisca
authors: F
authors: Vicente
authors: Olga
authors: O
authors: Genilloud
authors: Fernando
authors: F
authors: Reyes
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D006868:Hydrolysis; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008835:Micrococcaceae / Q000737:chemistry / Q000378:metabolism*; D010126:Ozone; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D011487:Protein Conformation; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010455:Peptides; D010456:Peptides, Cyclic; D013844:Thiazoles; C583478:kocurin; D010126:Ozone
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