title: Cardiovascular risk factors in women who had hypertensive disorders late in pregnancy: a cohort study.
abstract: OBJECTIVE
  The purpose of this study was to determine cardiovascular risk factors in women with a history of hypertensive pregnancy disorders at term (HTP) 2.5 years after pregnancy.
  
  
  METHODS
  In a multicenter cohort study in The Netherlands from June 2008 through November 2010, cardiovascular risk factors were compared between women with a history of HTP (HTP cohort, n = 306) and women with a history of normotensive pregnancies at term (NTP cohort, n = 99). HTP women had participated in a randomized, longitudinal trial assessing the effectiveness of induction of labor in women with hypertensive pregnancy disorders at term. All women were assessed 2.5 years after pregnancy for blood pressure, anthropometrics, glucose, glycosylated hemoglobin, insulin, homeostatic model assessment score, total cholesterol, high-density lipoprotein cholesterol, triglycerides, high-sensitivity C-reactive protein, and microalbumin and metabolic syndrome.
  
  
  RESULTS
  After a mean follow-up period of 2.5 years, hypertension (HTP, 34%; NTP, 1%; P < .001) and metabolic syndrome (HTP, 25%; NTP, 5%; P < .001) were more prevalent in HTP women compared with NTP women. HTP women had significantly higher systolic and diastolic blood pressure, higher body mass index, and higher waist circumference. Glucose, glycosylated hemoglobin, insulin, homeostatic model assessment score, total cholesterol, triglycerides, and high-sensitivity C-reactive protein levels were significantly higher and high-density lipoprotein cholesterol was significantly lower in HTP women.
  
  
  CONCLUSIONS
  In women with a history of HTP, hypertension and metabolic syndrome are more common, and they have higher levels of biochemical cardiovascular risk factors 2.5 years after pregnancy.
authors: Department of Obstetrics and Gynecology at Vu University Medical Center, Amsterdam, The Netherlands. herwie@mchaaglanden.nl
authors: Wietske
authors: W
authors: Hermes
authors: Arie
authors: A
authors: Franx
authors: Maria G
authors: MG
authors: van Pampus
authors: Kitty W M
authors: KW
authors: Bloemenkamp
authors: Michiel L
authors: ML
authors: Bots
authors: Joris A
authors: JA
authors: van der Post
authors: Martina
authors: M
authors: Porath
authors: Gabrielle A E
authors: GA
authors: Ponjee
authors: Jouke T
authors: JT
authors: Tamsma
authors: Ben Willem J
authors: BW
authors: Mol
authors: Christianne J M
authors: CJ
authors: de Groot
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology; D046110:Hypertension, Pregnancy-Induced / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology; D009426:Netherlands / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
chemical_list: D008076:Cholesterol, HDL