title: Cerebral oxygenation and haemodynamic effects induced by nimodipine in healthy subjects.
abstract: The cerebrovascular effects of nimodipine are still poorly understood even in the healthy condition; in particular, its effects on tissue oxygenation have never been investigated. The aim of the present study was to investigate changes in cerebral oxygenation and blood volume upon oral administration of nimodipine (90 mg) in the healthy condition. In eight subjects, changes in cerebral tissue oxygenation and blood volume were determined simultaneously with changes in blood velocity of the middle cerebral artery (VMCA) by using, respectively, near infrared spectroscopy (NIRS) and transcranial Doppler ultrasonography (TCD). The subjects also underwent noninvasive assessment of arterial blood pressure (ABP) and end-tidal CO2. TCD and NIRS CO2 reactivity indices were al-so extracted. Nimodipine signiﬁcantly reduced ABP (11±13%) and increased heart rate, as well as NIRS oxygenation(6.0±4.8%) and blood volume indices (9.4±10.1%), while V(MCA) was not signiﬁcantly decreased (2.0±3.5%). Nimodipine slightly but signiﬁcantly reduced the V(MCA) response to changes in pCO2 whereas the CO2 reactivity of NIRS parameters was improved. The observed changes in cerebral tissue oxygenation and blood volume indicate nimodipine-induced cerebrovascular dilation and increased perfusion, while the effect on V(MCA)possibly results from dilation of the insonated artery. The present results cast doubt on the putative nimodipine-induced impairment of CO2 reactivity.
authors: Neurovascular Laboratory, C. Mondino National Institute of Neurology, IRCCS, Pavia, Italy. daniela.canova@unito.it
authors: Daniela
authors: D
authors: Canova
authors: Silvestro
authors: S
authors: Roatta
authors: Giuseppe
authors: G
authors: Micieli
authors: Daniele
authors: D
authors: Bosone
mesh_terms: D000328:Adult; D062186:Arterial Pressure / Q000187:drug effects / Q000502:physiology; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006985:Hyperventilation; D007558:Italy; D008297:Male; D009553:Nimodipine / Q000008:administration & dosage / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects* / Q000502:physiology; D019265:Spectroscopy, Near-Infrared; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D002121:Calcium Channel Blockers; D009553:Nimodipine
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