title: Association of single nucleotide polymorphisms on chromosome 9p21.3 with cardiovascular death in kidney transplant recipients.
abstract: BACKGROUND
  Recipient death is a leading cause for renal allograft loss. Cardiovascular mortality is the most important cause of death among this patient group. Single nucleotide polymorphisms (SNPs) in a noncoding region close to the CDKN2a/b senescence genes have been associated with higher cardiovascular morbidity and mortality in nontransplant populations.
  
  
  METHODS
  We selected 2064 renal transplant recipients: 688 with a known cardiovascular cause of death and 1376 matched controls. DNA specimens were genotyped for the three SNPs with known risk allele (rs10757274, rs2383206, and rs10757278) and one SNP without risk allele (rs518394). Genotyping results were analyzed according to the frequency of risk alleles in the two groups.
  
  
  RESULTS
  The risk allele for three SNPs was detected significantly more often in patients with a known cardiovascular cause of death than in matched controls (all P<0.05). Diabetes and time on dialysis were modifiers of this effect with the presence of high-risk alleles having a stronger impact in diabetic patients and those with longer dialysis time. There was no difference between groups for the investigated SNP without risk allele.
  
  
  CONCLUSIONS
  Our results support data from large cohort studies in normal nontransplant populations, which suggested a higher risk for cardiovascular events in individuals carrying certain SNPs in senescence-associated genes. Notably, this finding was obtained in a population known to be at increased risk of cardiovascular death.
authors: Department of Pediatric Nephrology, Children's Hospital, Hannover Medical School, Hannover, Germany.
authors: Anette
authors: A
authors: Melk
authors: Carolin
authors: C
authors: Schildhorn
authors: Meike
authors: M
authors: Hömme
authors: Miriam
authors: M
authors: Knoch
authors: Bernhard M W
authors: BM
authors: Schmidt
authors: Jürgen
authors: J
authors: Serth
authors: Sabine
authors: S
authors: Scherer
authors: Bernd
authors: B
authors: Döhler
authors: Gerhard
authors: G
authors: Opelz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000401:mortality*; D016022:Case-Control Studies; D002423:Cause of Death; D016009:Chi-Square Distribution; D002899:Chromosomes, Human, Pair 9; D003920:Diabetes Mellitus / Q000401:mortality; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D006435:Renal Dialysis / Q000401:mortality; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult