title: [Evaluation in vitro of the cardiotoxic effects of 5-fluorouracil for the prevention of cardiovascular damage in health workers occupationally exposed].
abstract: The occupational exposure to antineoplastic drugs in health care workers determines a risk of absorption through inhalation of vapors or skin contact with drops. Even if many data confirm the cardiotoxicity of anthracyclines, is not clear the evidence of cytotoxicity of 5-Fluorouracil, thoug in a percent of patients receiving this chemotherapy, there is the presence of heart pain, aspecific ECG disorders and induction of coronary disease. This experimental study wants to analyze on the H9c2 cardiomyocyte cell model the effects of 5-Fluorouracil, commonly used in hospital realities of the South Italy, for the prevention of the possible cardiovascular damage in workers occupationally exposed.
authors: Seconda Università di Napoli, Dipartimento di Medicina Sperimentale, Via S. Maria di Costantinopoli 16, 80138 Napoli, Italy. monica.lamberti@unina2.it
authors: M
authors: M
authors: Lamberti
authors: M
authors: M
authors: Caraglia
authors: S
authors: S
authors: Zappavigna
authors: M
authors: M
authors: Marra
authors: C
authors: C
authors: Ritonnaro
authors: M A
authors: MA
authors: Coppola
authors: S
authors: S
authors: Naviglio
authors: S
authors: S
authors: Porto
authors: L
authors: L
authors: Marsella
authors: N
authors: N
authors: Sannolo
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D002478:Cells, Cultured; D005472:Fluorouracil / Q000633:toxicity*; D006282:Health Personnel; D009784:Occupational Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000517:prevention & control*; D051381:Rats
chemical_list: D005472:Fluorouracil