title: A novel plug-controlled colon-specific pulsatile capsule with tablet of curcumin-loaded SMEDDS.
abstract: This study developed and evaluated a colon-specific pulsatile capsule with tablet of self-microemulsifying drug delivery system (SMEDDS). This system is based on an impermeable capsule containing a rapid-disintegrating curcumin-loaded SMEDDS tablet inside it, and a highly methoxylated pectin (H-pectin)/lactose tablet plugged in the capsule mouth. The SMEDDS tablet enhanced the solubility of curcumin, a water-insoluble drug. An in vitro release study of the pulsatile capsule showed a typical pulsatile release profile with a specific lag time. The lag time, which determines the efficiency of colon-specific delivery, could be regulated by varying the H-pectin/lactose ratio. Pectinase and rat cecal contents added to the release medium significantly shortened the erosion time, which proved that the H-pectin plug is sensitive to enzyme degradation. These results show that the pulsatile capsule with SMEDDS tablet has potential for the colon-specific delivery of water-insoluble drugs.
authors: Chongqing Key Laboratory of Biochemistry & Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.
authors: Yuanrui
authors: Y
authors: Huang
authors: Rui
authors: R
authors: Tian
authors: Wenjing
authors: W
authors: Hu
authors: Yuntao
authors: Y
authors: Jia
authors: Jingqing
authors: J
authors: Zhang
authors: Huiming
authors: H
authors: Jiang
authors: Liangke
authors: L
authors: Zhang
mesh_terms: D000284:Administration, Oral; D000327:Adsorption; D000818:Animals; D001682:Biological Availability; D002214:Capsules; D003106:Colon / Q000378:metabolism*; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007785:Lactose / Q000737:chemistry; D008297:Male; D009928:Organ Specificity; D010368:Pectins / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013607:Tablets
chemical_list: D002214:Capsules; D013607:Tablets; D010368:Pectins; D003474:Curcumin; D007785:Lactose