title: [A case of hypomagnesemia linked to refractory hypokalemia and hypocalcemia with short bowel syndrome].
abstract: We report a case of a 59-year old Japanese woman with short bowel syndrome, whose hypokalemia and hypocalcemia were successfully treated with magnesium (Mg) supplementation. Two years previously, she underwent Mile's operation for advanced rectal cancer, which could have been the cause of subsequent extensive resection of the small intestine by strangulation. After serial resection, she gradually developed chronic diarrhea and anorexia. Three weeks before admission, she developed general fatigue and tetany, and was hospitalized at another hospital. On admission, her serum K and Ca were 2.5 mEq/L and 4.3 mg/dL, respectively, hence regular fluid therapy containing potassium (K) and calcium (Ca) was provided following admission. However, her hypokalemia and hypocalcemia persisted, and she also displayed renal dysfunction and thereafter was transferred to our department for further evaluation and treatment. Since the laboratory tests revealed severe hypomagnesemia (0.4 mg/dL), we started intravenous Mg supplementation together with fluid therapy containing K and Ca. After the combination therapy, her clinical symptoms and electrolyte disorders were remarkably improved within a week. As Mg is essential for PTH secretion in response to hypocalcemia and to inhibit the K channel activity that controls urinary K excretion, hypomagnesemia can cause hypocalcemia and hypokalemia, which is refractory to repletion therapy unless Mg is administered. Therefore, for patients who present with signs of Mg deficiency, early and accurate diagnosis of Mg deficiency should be made and corrected.
authors: Division of Nephrology and Dialysis, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, Japan.
authors: Yuki
authors: Y
authors: Sato
authors: Yuriko
authors: Y
authors: Yonekura
authors: Tatsuo
authors: T
authors: Tsukamoto
authors: Hiroko
authors: H
authors: Kakita
authors: Yuh
authors: Y
authors: Tateishi
authors: Toshiyuki
authors: T
authors: Komiya
authors: Satomi
authors: S
authors: Yonemoto
authors: Eri
authors: E
authors: Muso
mesh_terms: D005260:Female; D006801:Humans; D053565:Hypercalciuria / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D006996:Hypocalcemia / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D007008:Hypokalemia / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D009397:Nephrocalcinosis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D011188:Potassium / Q000097:blood; D015499:Renal Tubular Transport, Inborn Errors / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D012778:Short Bowel Syndrome / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D014883:Water-Electrolyte Imbalance / Q000503:physiopathology
chemical_list: D011188:Potassium