title: The role of adipose tissue in insulin resistance in women of African ancestry.
abstract: Women of African ancestry, particularly those living in industrialized countries, experience a disproportionately higher prevalence of type 2 diabetes (T2D) compared to their white counterparts. Similarly, obesity and insulin resistance, which are major risk factors for T2D, are greater in black compared to white women. The exact mechanisms underlying these phenomena are not known. This paper will focus on the role of adipose tissue biology. Firstly, the characteristic body fat distribution of women of African ancestry will be discussed, followed by the depot-specific associations with insulin resistance. Factors involved in adipose tissue biology and their relation to insulin sensitivity will then be explored, including the role of sex hormones, glucocorticoid metabolism, lipolysis and adipogenesis, and their consequent effects on adipose tissue hypoxia, oxidative stress, and inflammation. Finally the role of ectopic fat deposition will be discussed. The paper proposes directions for future research, in particular highlighting the need for longitudinal and/or intervention studies to better understand the mechanisms underlying the high prevalence of insulin resistance and T2D in women of African ancestry.
authors: UCT/MRC Research Unit for Exercise Science and Sports Medicine, South African Medical Research Council, Parow, Cape Town 7505, South Africa. julia.goedecke@uct.ac.za
authors: Julia H
authors: JH
authors: Goedecke
authors: Naomi S
authors: NS
authors: Levitt
authors: Juliet
authors: J
authors: Evans
authors: Nicole
authors: N
authors: Ellman
authors: David John
authors: DJ
authors: Hume
authors: Liske
authors: L
authors: Kotze
authors: Mehreen
authors: M
authors: Tootla
authors: Hendriena
authors: H
authors: Victor
authors: Dheshnie
authors: D
authors: Keswell
mesh_terms: D050156:Adipogenesis; D000273:Adipose Tissue / Q000378:metabolism / Q000503:physiopathology*; D000349:Africa / Q000208:ethnology; D044383:Black People; D050218:Body Fat Distribution; D015992:Body Mass Index; D015687:Cell Hypoxia; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance / Q000502:physiology*; D008066:Lipolysis; D009765:Obesity; D018384:Oxidative Stress
chemical_list: D005938:Glucocorticoids; D012739:Gonadal Steroid Hormones
references: Int J Endocrinol. 2012;2012:983814
references: 22675355
references: J Cell Physiol. 2008 Oct;217(1):1-12
references: 18543263
references: Mol Cell Biol. 2009 Aug;29(16):4467-83
references: 19546236
references: Obesity (Silver Spring). 2009 Feb;17(2):276-82
references: 19039315
references: Obesity (Silver Spring). 2011 Nov;19(11):2248-53
references: 21617639
references: Obes Res. 2001 Jan;9(1):10-6
references: 11346662
references: PLoS One. 2010 Feb 05;5(2):e9065
references: 20140090
references: Diabetes. 1996 Jun;45(6):742-8
references: 8635647
references: Clin Endocrinol (Oxf). 2006 Jul;65(1):81-7
references: 16817824
references: Metabolism. 2008 Aug;57(8):1071-7
references: 18640384
references: Diabetologia. 2008 Dec;51(12):2303-8
references: 18825363
references: Obes Res. 2002 May;10(5):336-44
references: 12006632
references: Obesity (Silver Spring). 2008 Dec;16(12):2696-701
references: 18927552
references: Diabetes. 2000 Aug;49(8):1374-80
references: 10923640
references: S Afr Med J. 2007 Aug;97(8 Pt 2):683-90
references: 17952225
references: Arterioscler Thromb Vasc Biol. 2007 Sep;27(9):2043-9
references: 17626902
references: Horm Metab Res. 2002 Nov-Dec;34(11-12):758-63
references: 12660895
references: Horm Metab Res. 2005 Nov;37(11):695-701
references: 16308839
references: J Intern Med. 1999 Aug;246(2):133-8
references: 10447781
references: Obes Res. 2002 Apr;10(4):266-9
references: 11943835
references: PLoS One. 2007 Jun 27;2(6):e569
references: 17593968
references: Clin Chim Acta. 2005 Apr;354(1-2):101-9
references: 15748605
references: Endocrinology. 2004 Jun;145(6):2707-12
references: 15044372
references: Science. 2001 Dec 7;294(5549):2166-70
references: 11739957
references: Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E999-E1003
references: 19622783
references: J Lipid Res. 2010 May;51(5):1193-200
references: 19965580
references: Diabetologia. 2012 Nov;55(11):3029-37
references: 22898765
references: Obes Surg. 2006 Oct;16(10):1342-50
references: 17059745
references: Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1823-8
references: 17311894
references: Blood. 2005 Jan 15;105(2):659-69
references: 15374877
references: J Clin Endocrinol Metab. 2011 Dec;96(12):E2029-33
references: 21956425
references: Metabolism. 2002 Nov;51(11):1514-8
references: 12404207
references: Biochem Biophys Res Commun. 2011 Jan 7;404(1):382-7
references: 21130749
references: J Clin Endocrinol Metab. 2001 Mar;86(3):1418-21
references: 11238541
references: Metabolism. 1991 Sep;40(9):990-6
references: 1895966
references: Lancet. 2001 Mar 10;357(9258):783-91
references: 11253984
references: Circulation. 2003 May 20;107(19):2422-7
references: 12719278
references: Obesity (Silver Spring). 2008 Sep;16(9):1983-91
references: 19186324
references: Int J Obes Relat Metab Disord. 2000 Nov;24 Suppl 4:S23-7
references: 11126235
references: Metabolism. 2004 Jan;53(1):1-3
references: 14681833
references: Nat Rev Mol Cell Biol. 2004 May;5(5):343-54
references: 15122348
references: Circulation. 2000 Jul 4;102(1):42-7
references: 10880413
references: Hepatology. 2004 Dec;40(6):1387-95
references: 15565570
references: Int J Obes Relat Metab Disord. 2000 Feb;24(2):226-31
references: 10702775
references: PLoS One. 2012;7(9):e43336
references: 22962583
references: Metabolism. 2003 Jun;52(6):735-8
references: 12800100
references: J Clin Endocrinol Metab. 1998 Nov;83(11):4084-91
references: 9814496
references: Am J Physiol. 1999 Sep;277(3):E551-60
references: 10484369
references: J Clin Endocrinol Metab. 2010 Sep;95(9):4441-8
references: 20591983
references: J Clin Endocrinol Metab. 2002 Jul;87(7):3330-6
references: 12107245
references: J Clin Endocrinol Metab. 2010 Aug;95(8):4052-5
references: 20466783
references: Obesity (Silver Spring). 2010 Nov;18(11):2191-8
references: 20339361
references: Diabetes Obes Metab. 2006 Sep;8(5):538-54
references: 16918589
references: Obesity (Silver Spring). 2011 Jan;19(1):43-8
references: 20559297
references: Obes Res. 2000 Mar;8(2):171-8
references: 10757203
references: Int J Obes (Lond). 2013 Apr;37(4):620-2
references: 22641063
references: Metabolism. 1996 Sep;45(9):1119-24
references: 8781299
references: Am J Physiol Regul Integr Comp Physiol. 2000 Sep;279(3):R944-50
references: 10956252
references: Obesity (Silver Spring). 2009 Aug;17(8):1506-12
references: 19300428
references: Diabetologia. 2006 Mar;49(3):588-97
references: 16463047
references: Diabetes. 2012 Jun;61(6):1399-403
references: 22492525
references: J Clin Endocrinol Metab. 2012 Nov;97(11):4051-60
references: 22879633
references: J Hepatol. 2012 May;56(5):1152-1158
references: 22245892
references: Obesity (Silver Spring). 2008 Dec;16(12):2561-5
references: 19279653
references: Am J Clin Nutr. 2005 Dec;82(6):1210-7
references: 16332653
references: J Clin Endocrinol Metab. 2008 Jul;93(7):2610-5
references: 18349063
references: J Clin Endocrinol Metab. 2006 Oct;91(10):4099-106
references: 16868062
references: Hepatology. 2009 Mar;49(3):791-801
references: 19105205
references: Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1849-55
references: 17035391
references: J Clin Pathol. 1979 May;32(5):471-4
references: 469004
references: Diabetes Care. 2009 May;32(5):860-5
references: 19196884
references: Diabet Med. 2007 Sep;24(9):934-45
references: 17725706
references: Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1191-6
references: 12006347
references: Int J Obes (Lond). 2011 Sep;35(9):1154-64
references: 21326205
references: Diabetes. 2009 Mar;58(3):718-25
references: 19074987
references: Obes Res. 2004 Jun;12(6):990-8
references: 15229339
references: Obesity (Silver Spring). 2010 May;18(5):879-83
references: 20186138
references: Obesity (Silver Spring). 2012 May;20(5):972-7
references: 22173574
references: Metabolism. 2010 Sep;59(9):1341-50
references: 20096899
references: Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E724-8
references: 16705059
references: Clin Endocrinol (Oxf). 2011 Jan;74(1):51-9
references: 20874774
references: J Clin Endocrinol Metab. 2003 Apr;88(4):1516-22
references: 12679432
references: Diabetologia. 2007 Aug;50(8):1707-15
references: 17549449
references: Int J Obes (Lond). 2010 Jun;34(6):949-59
references: 20065965
references: Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1663-9
references: 17911339