title: SUVmax of 18FDG PET/CT as a predictor of high-risk endometrial cancer patients.
abstract: OBJECTIVE
  To evaluate SUVmax in the assessment of endometrial cancer preoperatively with particular focus on myometrial invasion (MI), cervical invasion (CI), FIGO stage, risk-stratification and lymph node metastases (LNM).
  
  
  METHODS
  A total of 268 women with endometrial cancer or atypical endometrial hyperplasia underwent FDG PET/CT imaging before surgical treatment. SUVmax of the primary tumour was compared with histological prognostic factors.
  
  
  RESULTS
  SUVmax was significantly higher in patients with high FIGO stages (p<0.0001), deep MI (p=0.002), CI (p=0.04), LNM (p=0.04) and high risk tumours (p=0.003). Linear regression found that SUVmax was dependent of MI (p=0.001, 95% CI 2.863-11.098), CI (p=0.001, 95% CI 2.896-11.499), risk (p=0.004, 95% CI 0.077-0.397), LNM (p=0.04, 95% CI 0.011-0.482) and FIGO stage (p<0.0001, 95% CI 0.158-0.473).
  
  
  CONCLUSIONS
  Preoperative PET/CT scanning and SUVmax measurements of the primary tumour may provide additional clinical and prognostic information about MI, CI, LNM and high risk disease in patients with endometrial cancer and allow for individualization of patient care. However, the sensitivity and specificity of the SUVmax in staging endometrial cancer is not high enough to reliably replace surgical staging.
authors: Department of Gynaecology and Obstetrics, Rigshospitalet, Copenhagen University Hospital, Denmark. sleisby@dadlnet.dk
authors: Sofie Leisby
authors: SL
authors: Antonsen
authors: Annika
authors: A
authors: Loft
authors: Rune
authors: R
authors: Fisker
authors: Anne Lerberg
authors: AL
authors: Nielsen
authors: Erik Søgaard
authors: ES
authors: Andersen
authors: Estrid
authors: E
authors: Høgdall
authors: Ann
authors: A
authors: Tabor
authors: Kirsten
authors: K
authors: Jochumsen
authors: Carsten L
authors: CL
authors: Fagö-Olsen
authors: Jon
authors: J
authors: Asmussen
authors: Anne Kiil
authors: AK
authors: Berthelsen
authors: Ib Jarle
authors: IJ
authors: Christensen
authors: Claus
authors: C
authors: Høgdall
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002296:Carcinosarcoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007044:Hysterectomy; D016014:Linear Models; D008197:Lymph Node Excision; D008875:Middle Aged; D064847:Multimodal Imaging; D010052:Ovariectomy; D010388:Pelvis; D049268:Positron-Emission Tomography; D011300:Preoperative Care / Q000379:methods*; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D019275:Radiopharmaceuticals; D018570:Risk Assessment; D058994:Salpingectomy; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18