title: [Expression of thrombomodulin in malignant pleural mesothelioma].
abstract: The malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a role in the anti-coagulant process. We analyzed TM expression in biopsies of MM patients and in normal mesothelial tissue. The role of DNA methylation-associated gene silencing in TM expression was investigated. A correlation between low TM expression and high level of TM promoter methylation was found in MM biopsies. Low expression of TM was restored in MM cells by their treatment with 5-aza-2'-deoxycytidine while the epigenetic agent did not affect TM expression in Met-5A cells. Methylation of the TM promoter is responsible for silencing of TM expression in MM tissue.
authors: Dipartimento di Patologia Molecolare e Terapie Innovative, Clinica Medicina del Lavoro, Universith Politecnica delle Marche, via Tronto 10/A 60020 Torrette, Ancona. m.amati@univpm.it
authors: M
authors: M
authors: Amati
authors: I
authors: I
authors: Nocchi
authors: M
authors: M
authors: Tomasetti
authors: L
authors: L
authors: Santarelli
authors: F
authors: F
authors: Saccucci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000235:genetics*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000235:genetics*; D018180:Thrombomodulin / Q000235:genetics*
chemical_list: D018180:Thrombomodulin