title: Idiopathic membranous nephropathy and IgG4: an interesting relationship.
abstract: Idiopathic membranous nephropathy (iMN) is a single-organ autoimmune disease characterized by subepithelial deposition of immune complexes containing IgG4 resulting in proteinuria, nephrotic syndrome, and, in some, end-stage renal disease. The pathogenesis involves a chronic IgG4 response against specific podocyte antigens which have now been at least partially defined in the neonatal, early childhood, and adult varieties. More has recently been learned about the genetic predisposition as well. This review discusses the pathophysiology of iMN in light of these discoveries and what is known about the genesis and potential clinical ramifications of an antigen specific IgG4 response.
authors: Edward J
authors: EJ
authors: Filippone
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D015433:Glomerulonephritis, Membranous / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007668:Kidney / Q000276:immunology*; D010641:Phenotype; D012307:Risk Factors; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D000941:Antigens; D007074:Immunoglobulin G
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