title: [IL-6 expression in lung of rats subjected to brain ischemia].
abstract: OBJECTIVE
  To study the expression changes of interleukin-6 (IL-6) in the lung of rats with brain ischemia.
  
  
  METHODS
  Adult SD rats were divided into sham operation group and brain ischemia lung injury (BILI) group randomly. Focal cerebral ischemia inflammatory lung injury model was developed with intraluminal thread technique. RT-PCR was applied to detect the IL-6 expression level of lung at 24 h after brain ischemia. The IL-6 protein in lung at 48 h after brain ischemia was detected with Western blot. Immunohistochemistry method was used to demonstrate the IL-6 protein location in lung at 72 h after brain ischemia.
  
  
  RESULTS
  Increased immunostaining, protein level and mRNA expression for IL-6 were found in lung at investigated time point after brain ischemia.
  
  
  CONCLUSIONS
  IL-6, as a crucial preinflammatory factor, could be related to airway inflammation in rats induced by brain ischemia.
authors: Department of Respiration, Affiliated Kunhua Hospital of Kunming Science and Technology University, Kunming 650032, China.
authors: Yan
authors: Y
authors: Tan
authors: Shu-Yi
authors: SY
authors: Jiang
authors: Qi-Qin
authors: QQ
authors: Dan
authors: Yi-Lan
authors: YL
authors: Xia
authors: Jin-Tao
authors: JT
authors: Li
authors: Yun-Hui
authors: YH
authors: Zhang
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000378:metabolism*; D005260:Female; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D055370:Lung Injury / Q000209:etiology / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015850:Interleukin-6; D012333:RNA, Messenger