title: Downregulation of phosphatidylethanolamine binding protein 1 associates with clinical risk factors in gastrointestinal stromal tumors, but not with activation of the RAF-1-MEK-ETV1 pathway.
abstract: Aim of this study was to investigate phosphatidylethanolamine binding protein 1 (PEBP1) in GIST and its relations with MEK1/2 activation and ETV1 by immunohistochemistry. Loss of PEBP1 was found in 22/161 (13.7%) GIST, was associated with clinical risk factors and with a trend towards shorter disease free survival, but not with pMEK1/2 and ETV1 expression. So downregulation of PEBP1 does not activate the Ras-Raf-1-MEK1/2-ERK1/2 pathway by phosphorylation of MEK1/2 and does not influence ETV1 expression in GIST. Loss of PEBP1 associates with clinical risk factors, but since no significant influence on survival was found, further studies are required.
authors: Department of Surgery, Medical University of Vienna, Austria.
authors: Sebastian F
authors: SF
authors: Schoppmann
authors: Andrea
authors: A
authors: Beer
authors: Nadine
authors: N
authors: Nirtl
authors: Ahmed
authors: A
authors: Ba-Ssalamah
authors: Thomas
authors: T
authors: Brodowicz
authors: Berthold
authors: B
authors: Streubel
authors: Peter
authors: P
authors: Birner
mesh_terms: D000368:Aged; D004268:DNA-Binding Proteins / Q000378:metabolism; D018572:Disease-Free Survival; D015536:Down-Regulation; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000201:enzymology* / Q000401:mortality; D046152:Gastrointestinal Stromal Tumors / Q000201:enzymology* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism; D020935:MAP Kinase Signaling System; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D049488:Phosphatidylethanolamine Binding Protein / Q000235:genetics* / Q000378:metabolism; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism; D012307:Risk Factors; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; C095239:ETV1 protein, human; C511482:PEBP1 protein, human; D049488:Phosphatidylethanolamine Binding Protein; D014157:Transcription Factors; D019908:Proto-Oncogene Proteins c-raf; D020930:MAP Kinase Kinase Kinases