title: Acute diabetes insipidus mediated by vasopressinase after placental abruption.
abstract: BACKGROUND
  Postpartum, diabetes insipidus (DI) can be part of Sheehan's syndrome or lymphocytic hypophysitis in combination with anterior pituitary hormone deficiencies. In contrast, acute onset of isolated DI in the postpartum period is unusual.
  
  
  METHODS
  This patient presented at 33 weeks gestation with placental abruption, prompting a cesarean delivery of twins. Immediately after delivery, she developed severe DI. The DI could be controlled with the vasopressinase-resistant 1-deamino-8-D-arginine vasopressin (DDAVP), but not with arginine vasopressin (AVP), and it resolved within a few weeks.
  
  
  OBJECTIVE
  The aim of this study was to demonstrate that the postpartum DI in this patient was caused by the release of placental vasopressinase into the maternal bloodstream.
  
  
  RESULTS
  Cells were transiently transfected with the AVP receptor 2 (AVPR2) and treated with either AVP or DDAVP in the presence of the patient's serum collected postpartum or 10 weeks after delivery. The response to the different treatments was evaluated by measuring the activity of a cAMP-responsive firefly luciferase reporter construct. The in vitro studies demonstrate that the patient's postpartum serum disrupts activation of the AVPR2 by AVP, but not by the vasopressinase-resistant DDAVP.
  
  
  CONCLUSIONS
  Placental abruption can rarely be associated with acute postpartum DI caused by release of placental vasopressinase into the bloodstream. This clinical entity must be considered in patients with placental abruption and when evaluating patients presenting with DI after delivery.
authors: Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Tarry 15, 303 East Chicago Avenue, Chicago, Illinois 60611, USA.
authors: Amisha
authors: A
authors: Wallia
authors: Aigerim
authors: A
authors: Bizhanova
authors: Wenyu
authors: W
authors: Huang
authors: Susan L
authors: SL
authors: Goldsmith
authors: Dana R
authors: DR
authors: Gossett
authors: Peter
authors: P
authors: Kopp
mesh_terms: D000037:Abruptio Placentae / Q000097:blood* / Q000503:physiopathology; D000208:Acute Disease; D000328:Adult; D050034:Antidiuretic Agents / Q000008:administration & dosage*; D001127:Arginine Vasopressin / Q000008:administration & dosage; D002585:Cesarean Section; D010122:Cystinyl Aminopeptidase / Q000097:blood*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage*; D003919:Diabetes Insipidus / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D004351:Drug Resistance; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D049590:Postpartum Period / Q000097:blood / Q000187:drug effects; D011247:Pregnancy
chemical_list: D050034:Antidiuretic Agents; D001127:Arginine Vasopressin; D010122:Cystinyl Aminopeptidase; D003894:Deamino Arginine Vasopressin