title: Application of 'omics technologies to biomarker discovery in inflammatory lung diseases.
abstract: Inflammatory lung diseases are highly complex in respect of pathogenesis and relationships between inflammation, clinical disease and response to treatment. Sophisticated large-scale analytical methods to quantify gene expression (transcriptomics), proteins (proteomics), lipids (lipidomics) and metabolites (metabolomics) in the lungs, blood and urine are now available to identify biomarkers that define disease in terms of combined clinical, physiological and patho-biological abnormalities. The aspiration is that these approaches will improve diagnosis, i.e. define pathological phenotypes, and facilitate the monitoring of disease and therapy, and also, unravel underlying molecular pathways. Biomarker studies can either select predefined biomarker(s) measured by specific methods or apply an "unbiased" approach involving detection platforms that are indiscriminate in focus. This article reviews the technologies presently available to study biomarkers of lung disease within the 'omics field. The contributions of the individual 'omics analytical platforms to the field of respiratory diseases are summarised, with the goal of providing background on their respective abilities to contribute to systems medicine-based studies of lung disease.
authors: Division of Physiological Chemistry II, Karolinska Institutet, Stockholm.
authors: Craig E
authors: CE
authors: Wheelock
authors: Victoria M
authors: VM
authors: Goss
authors: David
authors: D
authors: Balgoma
authors: Ben
authors: B
authors: Nicholas
authors: Joost
authors: J
authors: Brandsma
authors: Paul J
authors: PJ
authors: Skipp
authors: Stuart
authors: S
authors: Snowden
authors: Dominic
authors: D
authors: Burg
authors: Arnaldo
authors: A
authors: D'Amico
authors: Ildiko
authors: I
authors: Horvath
authors: Amphun
authors: A
authors: Chaiboonchoe
authors: Hassan
authors: H
authors: Ahmed
authors: Stéphane
authors: S
authors: Ballereau
authors: Christos
authors: C
authors: Rossios
authors: Kian Fan
authors: KF
authors: Chung
authors: Paolo
authors: P
authors: Montuschi
authors: Stephen J
authors: SJ
authors: Fowler
authors: Ian M
authors: IM
authors: Adcock
authors: Anthony D
authors: AD
authors: Postle
authors: Sven-Erik
authors: SE
authors: Dahlén
authors: Anthony
authors: A
authors: Rowe
authors: Peter J
authors: PJ
authors: Sterk
authors: Charles
authors: C
authors: Auffray
authors: Ratko
authors: R
authors: Djukanovic
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D001944:Breath Tests / Q000379:methods; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002853:Chromatography, Liquid; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D007249:Inflammation; D050356:Lipid Metabolism; D008171:Lung Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D013058:Mass Spectrometry / Q000379:methods; D055432:Metabolomics / Q000379:methods; D010641:Phenotype; D011014:Pneumonia / Q000235:genetics / Q000378:metabolism; D040901:Proteomics / Q000379:methods; D013183:Sputum / Q000737:chemistry
chemical_list: D015415:Biomarkers