title: Antimicrobial activity of ceftaroline-avibactam tested against clinical isolates collected from U.S. Medical Centers in 2010-2011.
abstract: Ceftaroline-avibactam and comparator agents were tested by the broth microdilution method against 20,089 isolates consecutively collected in 2010 and 2011 from 75 U.S. medical centers. Ceftaroline-avibactam was active against Enterobacteriaceae (4,908 strains; MIC90, 0.25 μg/ml; highest MIC, 4 μg/ml), including meropenem-nonsusceptible Klebsiella spp. and ceftazidime-nonsusceptible Enterobacter cloacae strains (MIC90, 1 μg/ml for both). Ceftaroline-avibactam was also active against ceftriaxone-nonsusceptible Streptococcus pneumoniae (MIC(90), 0.25 μg/ml) and methicillin-resistant Staphylococcus aureus (MIC(90), 1 μg/ml).
authors: JMI Laboratories, North Liberty, Iowa, USA. helio-sader@jmilabs.com
authors: Helio S
authors: HS
authors: Sader
authors: Robert K
authors: RK
authors: Flamm
authors: Ronald N
authors: RN
authors: Jones
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D053961:Azabicyclo Compounds / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004338:Drug Combinations; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013296:Streptococcus pneumoniae / Q000187:drug effects; D000097583:Ceftaroline
chemical_list: D000890:Anti-Infective Agents; D053961:Azabicyclo Compounds; D002511:Cephalosporins; D004338:Drug Combinations; D000097583:Ceftaroline; C543519:avibactam
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