title: Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease.
abstract: The cytoplasmic lipid droplet (CLD) protein perilipin-2 (Plin2) is expressed in multiple nonadipose tissues, where it is thought to play a role in regulating their lipid storage properties. However, the extent to which Plin2 functions in nutrient utilization and metabolism, or how it influences the consequences of over-feeding, remains unclear. In this study, we demonstrate that the absence of Plin2 prevents high-fat diet(HFD)-induced obesity in male and female mice. This response is associated with increased formation of subcutaneous beige adipocyte cells with uncoupling protein 1 expression, and amelioration of inflammatory foci formation in white adipose tissue and steatosis in the liver. Experiments demonstrate that Plin2 loss results in reduced energy intake and increased physical activity in response to HFD feeding. Our study provides the first evidence that Plin2 contributes to HFD-induced obesity by modulating food intake, and that its absence prevents obesity-associated adipose tissue inflammatory foci and liver steatosis.
authors: Division of Basic Reproductive Sciences, University of Colorado School of Medicine, Aurora, CO, USA. jim.mcmanaman@ucdenver.edu
authors: James L
authors: JL
authors: McManaman
authors: Elise S
authors: ES
authors: Bales
authors: David J
authors: DJ
authors: Orlicky
authors: Matthew
authors: M
authors: Jackman
authors: Paul S
authors: PS
authors: MacLean
authors: Shannon
authors: S
authors: Cain
authors: Amanda E
authors: AE
authors: Crunk
authors: Ayla
authors: A
authors: Mansur
authors: Christine E
authors: CE
authors: Graham
authors: Thomas A
authors: TA
authors: Bowman
authors: Andrew S
authors: AS
authors: Greenberg
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D059305:Diet, High-Fat; D005234:Fatty Liver / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009765:Obesity / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000070780:Perilipin-2
chemical_list: D008565:Membrane Proteins; D000070780:Perilipin-2; C000602983:Plin2 protein, mouse
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