title: Association of craniopharyngioma and pituitary adenoma.
abstract: Intracranial tumors of different histologic types infrequently affect patients with pituitary adenomas and no history of head irradiation. The association with craniopharyngioma is extremely rare. Aims of this paper are: (1) to provide a critical literature review of typical features of pituitary adenoma presenting in association with craniopharyngioma; (2) to describe the first documented (clinically, biochemically, histologically, and radiologically) case of aggressive, suprasellar papillary craniopharyngioma presenting with amenorrhea, progressive reduction of visual field, and severe headache in a 38-year-old woman, a decade after surgical cure for microprolactinoma associated with empty sella, during which she had carried two pregnancies; and (3) to discuss common etiopathogenetic mechanisms, in relation to the management of these lesions. Systematic literature search for English literature focusing on the association of craniopharyngioma and pituitary adenoma was performed using PubMed database. Additional relevant articles from references lists were also included. Clinical, laboratory, and radiological examinations performed in our patient for the two brain lesions at diagnosis and follow up were collected. Literature search retrieved nine articles. Typically, craniopharyngioma were of adamantinomatous type, occurred simultaneously to pituitary adenoma, presented with headache and visual loss, and affected men. No case of clearly documented metachronous lesion affecting a woman after pregnancy had been described before. Although very rare and with uncertain etiopathogenesis, second tumors (i.e., craniopharyngioma) should be considered in patients with a history of pituitary adenoma, presenting with suggestive signs and symptoms, even after a long disease-free period, in order to provide proper and prompt treatment.
authors: Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, Città della Salute e della Scienza Hospital, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy. federica.guaraldi@unito.it
authors: Federica
authors: F
authors: Guaraldi
authors: Nunzia
authors: N
authors: Prencipe
authors: Valentina
authors: V
authors: di Giacomo
authors: Massimo
authors: M
authors: Scanarini
authors: Valentina
authors: V
authors: Gasco
authors: Marina Paola
authors: MP
authors: Gardiman
authors: Alessandro M
authors: AM
authors: Berton
authors: Ezio
authors: E
authors: Ghigo
authors: Silvia
authors: S
authors: Grottoli
mesh_terms: D000236:Adenoma / Q000150:complications*; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis; D003397:Craniopharyngioma / Q000150:complications*; D005260:Female; D006261:Headache / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis; D010911:Pituitary Neoplasms / Q000150:complications*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis; D015175:Prolactinoma / Q000150:complications / Q000175:diagnosis
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