title: Rapid preparation of molecularly imprinted polymer by frontal polymerization.
abstract: Frontal polymerization was successfully applied, for the first time, to obtain molecularly imprinted polymers (MIPs). The method provides a solvent-free polymerization mode, and the reaction can be completed in 30 min. By this approach, MIPs were synthesized using a mixture of levofloxacin (template), methacrylic acid, and divinylbenzene. The effect of template concentration and the amount of comonomer on the imprinting effect of the resulting MIPs was investigated. The textural and morphological parameters of the MIP particles were also characterized by mercury intrusion porosimetry, nitrogen adsorption isotherms, and scanning electron microscopy, providing evidence concerning median pore diameter, pore volumes, and pore size distributions. The levofloxacin-imprinted polymer formed in frontal polymerization mode showed high selectivity, with an imprinting factor of 5.78. The results suggest that frontal polymerization provides an alternative means to prepare MIPs that are difficult to synthesize and may open up new perspectives in the field of MIPs.
authors: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China.
authors: Dan-Dan
authors: DD
authors: Zhong
authors: Xin
authors: X
authors: Liu
authors: Qian-Qian
authors: QQ
authors: Pang
authors: Yan-Ping
authors: YP
authors: Huang
authors: Zhao-Sheng
authors: ZS
authors: Liu
mesh_terms: D000327:Adsorption; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D064704:Levofloxacin; D054802:Molecular Imprinting; D015242:Ofloxacin / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D016062:Porosity; D013818:Thermogravimetry
chemical_list: D011108:Polymers; D064704:Levofloxacin; D015242:Ofloxacin