title: A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus.
abstract: Simultaneous implementation of magnetic resonance imaging methods for Arterial Spin Labeling (ASL) and Blood Oxygenation Level Dependent (BOLD) imaging makes it possible to quantitatively measure the changes in cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO(2)) that occur in response to neural stimuli. To date, however, the range of neural stimuli amenable to quantitative analysis is limited to those that may be presented in a simple block or event related design such that measurements may be repeated and averaged to improve precision. Here we examined the feasibility of using the relationship between cerebral blood flow and the BOLD signal to improve dynamic estimates of blood flow fluctuations as well as to estimate metabolic-hemodynamic coupling under conditions where a stimulus pattern is unknown. We found that by combining the information contained in simultaneously acquired BOLD and ASL signals through a method we term BOLD Constrained Perfusion (BCP) estimation, we could significantly improve the precision of our estimates of the hemodynamic response to a visual stimulus and, under the conditions of a calibrated BOLD experiment, accurately determine the ratio of the oxygen metabolic response to the hemodynamic response. Importantly we were able to accomplish this without utilizing a priori knowledge of the temporal nature of the neural stimulus, suggesting that BOLD Constrained Perfusion estimation may make it feasible to quantitatively study the cerebral metabolic and hemodynamic responses to more natural stimuli that cannot be easily repeated or averaged.
authors: Department of Bioengineering and Medical Scientist Training Program, University of California San Diego, La Jolla, California, USA.
authors: Aaron B
authors: AB
authors: Simon
authors: Valerie E M
authors: VE
authors: Griffeth
authors: Eric C
authors: EC
authors: Wong
authors: Richard B
authors: RB
authors: Buxton
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000098:blood supply* / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D010101:Oxygen Consumption
references: J Cereb Blood Flow Metab. 2008 Jul;28(7):1377-87
references: 18382468
references: Neuroimage. 2005 Jan 1;24(1):207-15
references: 15588612
references: Magn Reson Med. 1998 Jun;39(6):912-9
references: 9621914
references: Pain. 2008 May;136(1-2):85-96
references: 17716820
references: Neuroimage. 2007 Aug 1;37(1):90-101
references: 17560126
references: Proc Natl Acad Sci U S A. 1986 Feb;83(4):1140-4
references: 3485282
references: Neuroimage. 2009 Feb 1;44(3):857-69
references: 18951982
references: Magn Reson Med. 1997 Jun;37(6):877-84
references: 9178239
references: Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1834-9
references: 9465103
references: Neuroimage. 2012 Apr 15;60(3):1759-70
references: 22209809
references: Neuroimage. 2010 Nov 1;53(2):383-91
references: 20624474
references: Hum Brain Mapp. 2005 Sep;26(1):15-29
references: 15852468
references: Magn Reson Med. 1992 Jan;23(1):37-45
references: 1734182
references: NMR Biomed. 1997 Jun-Aug;10(4-5):237-49
references: 9430354
references: Magn Reson Med. 1995 May;33(5):636-47
references: 7596267
references: IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
references: 11293691
references: Nat Rev Neurosci. 2004 May;5(5):347-60
references: 15100718
references: Neuroimage. 2008 Feb 15;39(4):1510-21
references: 18164629
references: Magn Reson Med. 1998 Jun;39(6):855-64
references: 9621908
references: J Neurosci. 1996 Jul 1;16(13):4207-21
references: 8753882
references: Neuroimage. 2008 Mar 1;40(1):237-47
references: 18191583
references: Neuroimage. 2011 Sep 1;58(1):198-212
references: 21669292
references: Magn Reson Med. 1991 Apr;18(2):257-68
references: 2046511
references: Neuroimage. 2012 Mar;60(1):279-89
references: 22155329
references: Science. 1999 Nov 19;286(5444):1555-8
references: 10567261
references: Neuroimage. 2009 Jul 1;46(3):559-68
references: 19303450
references: Magn Reson Med. 2000 Jul;44(1):162-7
references: 10893535
references: Magn Reson Med. 2000 Jul;44(1):92-100
references: 10893526
references: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
references: 15976020
references: Magn Reson Med. 1995 Oct;34(4):537-41
references: 8524021
references: Comput Biomed Res. 1996 Jun;29(3):162-73
references: 8812068
references: Front Neuroenergetics. 2010 Jun 17;2:8
references: 20616882
references: J Cereb Blood Flow Metab. 2004 Jul;24(7):764-70
references: 15241184
references: Neuroimage. 2006 Jul 1;31(3):1104-15
references: 16533609
references: Magn Reson Med. 2005 Aug;54(2):491-8
references: 16032686
references: J Cereb Blood Flow Metab. 2009 Nov;29(11):1856-66
references: 19654592
references: Proc Natl Acad Sci U S A. 1990 Dec;87(24):9868-72
references: 2124706
references: Magn Reson Med. 2005 Mar;53(3):735-8
references: 15723412
references: Neuroimage. 2000 Oct;12(4):466-77
references: 10988040
references: Neuroimage. 2011 Aug 1;57(3):809-16
references: 21586328
references: J Magn Reson Imaging. 2005 Dec;22(6):727-31
references: 16261572
references: Magn Reson Med. 1998 May;39(5):702-8
references: 9581600
references: Neuroimage. 2009 Nov 15;48(3):515-24
references: 19607928
references: Neuroimage. 2008 Aug 1;42(1):296-305
references: 18514545
references: Science. 2004 Mar 12;303(5664):1634-40
references: 15016991
references: NMR Biomed. 1997 Jun-Aug;10(4-5):165-70
references: 9430343
references: Front Neuroinform. 2010 Mar 19;4:5
references: 20428497
references: J Cereb Blood Flow Metab. 1999 Jun;19(6):679-89
references: 10366199
references: Magn Reson Imaging. 2008 Sep;26(7):863-9
references: 18479869