title: [Bone metabolism, biochemical markers of bone resorption and formation processes and interleukine 6 cytokin level during coeliac disease].
abstract: BACKGROUND
  Celiac disease (CD) is characterized by a malabsorption syndrom. The bone anomalies are one of the principal complications of this disease. The osteoporosis frequency is high: 3.4% among patients having with CD versus 0.2% in the general population.
  
  
  OBJECTIVE
  To study the bone mineral density during the CD, to compare it to a control group and to determine the anomalies of biochemical markers of bone turn over and level of interleukin 6 cytokin (IL6) in these patients.
  
  
  METHODS
  All patients with CD have a measurement of bone mineral density by dual-energy x-ray absorptiometry (DXA), a biological exam with dosing calcemia, vitamin D, parathormone (PTH), the osteoblastic bone formation markers (serum osteocalcin, ALP phosphates alkaline), bone osteoclastic activity (C Télopeptide: CTX) and of the IL6.
  
  
  RESULTS
  42 patients were included, with a median age of 33.6 years. 52. 8% of the patients had a low level of D vitamine associated to a high level of PTH. An osteoporosis was noted in 21.5% of patients. No case of osteoporosis was detected in the control group. The mean level of the CTX, ostéocalcine and the IL6 was higher among patients having an osteoporosis or ostéopenia compared to patients with normal bone (p = 0,017). The factors associated with an bone loss (osteopenia or osteoporosis) were: an age > 30 years, a weight <50 kg, a level of ALP phosphates alkaline > 90 UI/ml, an hypo albuminemia < 40 g/l and a level of CTX higher than 1.2.
  
  
  CONCLUSIONS
  Our study confirms the impact of the CD on the bone mineral statute. The relative risk to have an osteopenia or an osteoporosis was 5 in our series. The measurement of the osseous mineral density would be indicated among patients having a CD.
authors: Service de Gastro entérologie A, Hôpital la Rabta, Tunis, Tunisie, Faculté de Médecine de Tunis, Université de Tunis El Manar.
authors: Monia
authors: M
authors: Fekih
authors: Hela
authors: H
authors: Sahli
authors: Nadia
authors: N
authors: Ben Mustapha
authors: Imen
authors: I
authors: Mestiri
authors: Moncef
authors: M
authors: Fekih
authors: Jalel
authors: J
authors: Boubaker
authors: Naziha
authors: N
authors: Kaabachi
authors: Mohamed
authors: M
authors: Sellami
authors: Lamia
authors: L
authors: Kallel
authors: Azza
authors: A
authors: Filali
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D002446:Celiac Disease / Q000378:metabolism*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D015850:Interleukin-6