title: Physiological basis for emotional modulation of memory circuits by the amygdala.
abstract: Classical experiments have demonstrated that the amygdala facilitates synaptic plasticity in other brain structures (e.g. hippocampus, basal ganglia) believed to constitute the storage sites for various types of memory. Here, we summarize new developments in our understanding of how the amygdala facilitates the formation of emotional memories. Recent insights into this question have come from studies relying on simultaneous recording of neurons in multiple brain regions during learning. This approach has revealed that in emotionally arousing conditions, whether positively or negatively valenced, the amygdala allows incoming information to be processed more efficiently in distributed cerebral networks. This review also highlights the need to understand how different brain regions act in parallel to efficiently achieve one goal.
authors: Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. rony.paz@weizmann.ac.il
authors: Rony
authors: R
authors: Paz
authors: Denis
authors: D
authors: Pare
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology
references: Prog Neurobiol. 2004 Oct;74(2):101-10
references: 15518955
references: Biol Psychiatry. 2011 Jun 15;69(12):1133-9
references: 20889144
references: Learn Mem. 2008 Jul 08;15(7):524-31
references: 18612069
references: Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):341-6
references: 17182737
references: Annu Rev Psychol. 2005;56:207-34
references: 15709934
references: J Comp Neurol. 1984 Dec 20;230(4):465-96
references: 6520247
references: Neuropharmacology. 2010 Jun;58(7):951-61
references: 20096294
references: J Neurophysiol. 2001 Jul;86(1):164-72
references: 11431498
references: Trends Neurosci. 1998 Jul;21(7):294-9
references: 9683321
references: Neuroimage. 2012 Oct 15;63(1):591-9
references: 22750720
references: Annu Rev Neurosci. 2004;27:1-28
references: 15217324
references: Curr Opin Neurobiol. 2001 Dec;11(6):752-6
references: 11741029
references: Nat Rev Neurosci. 2010 Nov;11(11):773-83
references: 20959860
references: Neuron. 2012 Jul 12;75(1):133-42
references: 22794267
references: Neurobiol Learn Mem. 1997 Jul;68(1):42-50
references: 9195588
references: Nat Neurosci. 2009 Jun;12(6):801-7
references: 19430471
references: Behav Brain Funct. 2010 Apr 23;6:24
references: 20416052
references: J Neurophysiol. 2010 Sep;104(3):1673-80
references: 20554836
references: Trends Cogn Sci. 2010 May;14(5):195-200
references: 20227327
references: Exp Brain Res. 2010 Jan;200(3-4):307-17
references: 19904530
references: J Comp Neurol. 2006 Apr 20;495(6):722-34
references: 16506192
references: Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):8016-21
references: 8755595
references: Trends Neurosci. 2004 May;27(5):250-6
references: 15111006
references: Nat Neurosci. 2006 Oct;9(10):1321-9
references: 16964249
references: J Neurosci. 2007 Aug 29;27(35):9369-79
references: 17728450
references: J Comp Neurol. 1994 Apr 8;342(2):232-48
references: 7911130
references: Annu Rev Neurosci. 2002;25:563-93
references: 12052921
references: Physiol Rev. 2010 Apr;90(2):419-63
references: 20393190
references: J Comp Neurol. 2013 Aug 1;521(11):2538-50
references: 23296922
references: J Neurosci. 2009 Oct 14;29(41):12831-8
references: 19828796
references: Annu Rev Neurosci. 2011;34:259-88
references: 21456960
references: Nat Rev Neurosci. 2001 Jan;2(1):51-61
references: 11253359
references: Nature. 2012 Nov 22;491(7425):547-53
references: 23172213
references: Annu Rev Neurosci. 2012;35:227-47
references: 22443508
references: Rev Neurosci. 1994 Jul-Sep;5(3):227-50
references: 7889215
references: Behav Neurosci. 1997 Jun;111(3):543-51
references: 9189269
references: Neurobiol Learn Mem. 1998 Mar;69(2):163-203
references: 9619995
references: J Neurophysiol. 2004 May;91(5):2079-89
references: 15069098
references: Prog Neurobiol. 1998 Jun;55(3):257-332
references: 9643556
references: Cell. 2011 Oct 28;147(3):509-24
references: 22036561
references: Nat Neurosci. 2005 Apr;8(4):512-8
references: 15735643
references: Neuropsychology. 1997 Jan;11(1):104-13
references: 9055274
references: J Comp Neurol. 1990 Aug 1;298(1):40-9
references: 1698828
references: J Neurosci. 2012 Jun 20;32(25):8589-97
references: 22723700
references: Neuron. 2010 Jun 24;66(6):949-62
references: 20620879
references: Behav Neurosci. 2011 Dec;125(6):797-824
references: 22122145
references: J Neurosci. 2007 Jun 13;27(24):6542-51
references: 17567815
references: Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8477-81
references: 8078906
references: Curr Opin Neurobiol. 2012 Aug;22(4):717-23
references: 22424846
references: J Neurosci. 1992 Nov;12(11):4224-33
references: 1359031
references: J Neurophysiol. 2009 May;101(5):2507-15
references: 19244352