title: Endotoxin adsorption by polymyxin B column or intraaortic balloon pumping use for severe septic cardiomyopathy.
abstract: Septic patients often have low cardiac output. Some of them present severe cardiac dysfunction such as septic cardiomyopathy. However, no well-known and effective treatment for septic cardiomyopathy exists. The effect of endotoxin adsorption by polymyxin B–immobilized fiber column–direct hemoperfusion (PMX-DHP) and intraaortic balloon pumping (IABP) for septic shock remains uncertain. We experienced 2 very contrastive case reports of severe septic cardiomyopathy. We experienced 2 cases of severe septic cardiomyopathy with refractory shock. Case 1 with colon perforation presented refractory shock 6 hours after PMX-DHP, and IABP immediately improved her hemodynamics. In contrast, IABP had no effect at all in case 2 with viral enteritis, but PMXDHP improved her blood pressure and stroke volume markedly. The probability of impaired coronary microcirculation and relative bradycardia is the least required conditions for IABP use in severe septic cardiomyopathy. Meanwhile, PMX-DHP could be a good option for septic cardiomyopathy because of its fewer complications.
authors: Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, Tokyo 113-8655, Japan. Nakamurak-eme@h.u-tokyo.ac.jp
authors: Kensuke
authors: K
authors: Nakamura
authors: Kent
authors: K
authors: Doi
authors: Ryota
authors: R
authors: Inokuchi
authors: Tatsuma
authors: T
authors: Fukuda
authors: Takahiro
authors: T
authors: Hiruma
authors: Takeshi
authors: T
authors: Ishii
authors: Susumu
authors: S
authors: Nakajima
authors: Eisei
authors: E
authors: Noiri
authors: Naoki
authors: N
authors: Yahagi
mesh_terms: D000368:Aged; D009202:Cardiomyopathies / Q000209:etiology / Q000628:therapy*; D003131:Combined Modality Therapy; D004731:Endotoxins; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D011112:Polymyxin B; D012772:Shock, Septic / Q000150:complications / Q000628:therapy*; D055815:Young Adult
chemical_list: D004731:Endotoxins; D011112:Polymyxin B