title: The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner.
abstract: Early B-cell factor 1 (Ebf1) is a transcription factor whose inactivation in all cells results in high bone mass because of an increase in bone formation. This observation suggests Ebf1 may be an inhibitor of osteoblast differentiation. To test this contention, we analyzed Ebf1 pattern of expression and function in osteoblasts ex vivo and in vivo through osteoblast-specific inactivation in the mouse. We show here that in vivo deletion of Ebf1 in osteoblast progenitors does not affect osteoblast differentiation or bone formation accrual post-natally. These observations indicate that the phenotype described in Ebf1(-/)(-) mice is not osteoblast-autonomous.
authors: Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
authors: Tiffany
authors: T
authors: Zee
authors: Sören
authors: S
authors: Boller
authors: Ildiko
authors: I
authors: Györy
authors: Munevver P
authors: MP
authors: Makinistoglu
authors: Jan P
authors: JP
authors: Tuckermann
authors: Rudolf
authors: R
authors: Grosschedl
authors: Gerard
authors: G
authors: Karsenty
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism*; D002454:Cell Differentiation; D004622:Embryo, Mammalian; D017353:Gene Deletion; D018507:Gene Expression Regulation, Developmental; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D010012:Osteogenesis / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism
chemical_list: C489921:Ebf1 protein, mouse; D015534:Trans-Activators
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