title: Applying ecological and evolutionary theory to cancer: a long and winding road.
abstract: Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenesis, evasion of the immune system, metastasis, and resistance to therapies). Historically, little attention has been placed on applications of evolutionary biology to understanding and controlling neoplastic progression and to prevent therapeutic failures. This is now beginning to change, and there is a growing international interest in the interface between cancer and evolutionary biology. The objective of this introduction is first to describe the basic ideas and concepts linking evolutionary biology to cancer. We then present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays. Finally, we discuss several of the most promising challenges and future prospects in this interdisciplinary research direction in the war against cancer.
authors: MIVEGEC (UMR CNRS/IRD/UM1) 5290 Montpellier Cedex 5, France ; CREEC Montpellier Cedex 5, France.
authors: Frédéric
authors: F
authors: Thomas
authors: Daniel
authors: D
authors: Fisher
authors: Philippe
authors: P
authors: Fort
authors: Jean-Pierre
authors: JP
authors: Marie
authors: Simon
authors: S
authors: Daoust
authors: Benjamin
authors: B
authors: Roche
authors: Christoph
authors: C
authors: Grunau
authors: Céline
authors: C
authors: Cosseau
authors: Guillaume
authors: G
authors: Mitta
authors: Stephen
authors: S
authors: Baghdiguian
authors: François
authors: F
authors: Rousset
authors: Patrice
authors: P
authors: Lassus
authors: Eric
authors: E
authors: Assenat
authors: Damien
authors: D
authors: Grégoire
authors: Dorothée
authors: D
authors: Missé
authors: Alexander
authors: A
authors: Lorz
authors: Frédérique
authors: F
authors: Billy
authors: William
authors: W
authors: Vainchenker
authors: François
authors: F
authors: Delhommeau
authors: Serge
authors: S
authors: Koscielny
authors: Raphael
authors: R
authors: Itzykson
authors: Ruoping
authors: R
authors: Tang
authors: Fanny
authors: F
authors: Fava
authors: Annabelle
authors: A
authors: Ballesta
authors: Thomas
authors: T
authors: Lepoutre
authors: Liliana
authors: L
authors: Krasinska
authors: Vjekoslav
authors: V
authors: Dulic
authors: Peggy
authors: P
authors: Raynaud
authors: Philippe
authors: P
authors: Blache
authors: Corinne
authors: C
authors: Quittau-Prevostel
authors: Emmanuel
authors: E
authors: Vignal
authors: Hélène
authors: H
authors: Trauchessec
authors: Benoit
authors: B
authors: Perthame
authors: Jean
authors: J
authors: Clairambault
authors: Vitali
authors: V
authors: Volpert
authors: Eric
authors: E
authors: Solary
authors: Urszula
authors: U
authors: Hibner
authors: Michael E
authors: ME
authors: Hochberg
keywords: cancer, disease biology; evolutionary medicine; evolutionary theory
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