title: Immunological aspects of Candida and Aspergillus systemic fungal infections.
abstract: Patients with allogeneic stem cell transplantation (SCT) have a high risk of invasive fungal infections (IFIs) even after neutrophil regeneration. Immunological aspects might play a very important role in the IFI development in these patients. Some data are available supporting the identification of high-risk patients with IFI for example patients receiving stem cells from TLR4 haplotype S4 positive donors. Key defense mechanisms against IFI include the activation of neutrophils, the phagocytosis of germinating conidia by dendritic cells, and the fight of the cells of the innate immunity such as monocytes and natural killer cells against germlings and hyphae. Furthermore, immunosuppressive drugs interact with immune effector cells influencing the specific fungal immune defense and antimycotic drugs might interact with immune response. Based on the current knowledge on immunological mechanism in Aspergillus fumigatus, the first approaches of an immunotherapy using human T cells are in development. This might be an option for the future of aspergillosis patients having a poor prognosis with conventional treatment.
authors: Medical Writer, Goldammerweg 4, 91301 Forchheim, Germany.
authors: Christoph
authors: C
authors: Mueller-Loebnitz
authors: Helmut
authors: H
authors: Ostermann
authors: Anke
authors: A
authors: Franzke
authors: Juergen
authors: J
authors: Loeffler
authors: Lutz
authors: L
authors: Uharek
authors: Max
authors: M
authors: Topp
authors: Hermann
authors: H
authors: Einsele
references: Blood. 2006 Mar 15;107(6):2562-9
references: 16322466
references: Blood. 2009 Sep 24;114(13):2619-22
references: 19541821
references: Ann Oncol. 2009 Sep;20(9):1560-1564
references: 19451183
references: Infect Immun. 1983 Dec;42(3):1109-15
references: 6642661
references: J Immunol. 2010 Jan 15;184(2):912-21
references: 20008295
references: J Infect Dis. 1994 Oct;170(4):894-9
references: 7930733
references: J Infect Dis. 2006 May 15;193(10):1408-18
references: 16619189
references: Transpl Immunol. 2005 Aug;14(3-4):203-6
references: 15982564
references: Eukaryot Cell. 2007 Dec;6(12):2290-302
references: 17921349
references: Clin Exp Immunol. 2005 Feb;139(2):257-67
references: 15654824
references: Eur J Haematol. 2008 May;80(5):436-43
references: 18194476
references: Clin Infect Dis. 2008 Jun 15;46(12):1813-21
references: 18462102
references: J Immunol. 1997 Jan 1;158(1):322-9
references: 8977206
references: Nat Rev Immunol. 2006 Mar;6(3):173-82
references: 16498448
references: Nature. 2009 Aug 27;460(7259):1117-21
references: 19713928
references: J Immunol. 2002 Dec 1;169(11):6298-308
references: 12444136
references: Ann N Y Acad Sci. 2005 Dec;1062:95-103
references: 16461792
references: J Clin Invest. 2007 Dec;117(12):3664-72
references: 17992260
references: Clin Infect Dis. 2008 Nov 1;47(9):1176-84
references: 18808352
references: J Immunol. 2009 Apr 1;182(7):4306-12
references: 19299730
references: J Infect Dis. 2001 Feb 1;183(3):518-20
references: 11133388
references: Antimicrob Agents Chemother. 1998 Sep;42(9):2299-303
references: 9736553
references: J Infect Dis. 2008 Mar 15;197(6):924-31
references: 18279049
references: Clin Immunol. 2001 Mar;98(3):327-36
references: 11237556
references: Am J Respir Crit Care Med. 2004 Sep 15;170(6):621-5
references: 15229094
references: J Hosp Infect. 2008 Mar;68(3):270-1
references: 18226417
references: J Clin Oncol. 2009 Aug 10;27(23):3849-54
references: 19597026
references: Bone Marrow Transplant. 2005 Dec;36(12):1089-95
references: 16247433
references: Cell Microbiol. 2008 Mar;10(3):807-20
references: 18034864
references: Infect Immun. 2003 Jun;71(6):3034-42
references: 12761080
references: Blood. 2005 Dec 15;106(13):4397-406
references: 16123217
references: J Immunol. 2002 Feb 1;168(3):1362-71
references: 11801677
references: Intensive Care Med. 2007 Apr;33(4):606-18
references: 17323051
references: J Clin Invest. 1996 May 15;97(10):2324-31
references: 8636413
references: Cell Microbiol. 2006 Nov;8(11):1687-96
references: 16939535
references: Microbes Infect. 2002 Nov;4(13):1281-90
references: 12443892
references: N Engl J Med. 2008 Oct 23;359(17):1766-77
references: 18946062
references: Clin Infect Dis. 2006 Sep 1;43(5):577-84
references: 16886149
references: J Med Microbiol. 2009 Jan;58(Pt 1):49-58
references: 19074652
references: J Leukoc Biol. 2001 Dec;70(6):868-72
references: 11739548
references: J Clin Invest. 1998 May 1;101(9):1835-42
references: 9576746
references: N Engl J Med. 2009 Oct 29;361(18):1727-35
references: 19864672