title: Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma.
abstract: We present the case of a 62-year-old Japanese woman with relapsed adult T-cell leukemia/lymphoma (ATLL) who was treated with humanized anti-CCR4 monoclonal antibody (KW-0761). Although this antibody was highly effective against refractory ATLL, 6 months after the final KW-0761 infusion, the patient complained of hypoxia due to diffuse panbronchiolitis. Physicians should remain vigilant to the possibility of such previously unreported late-onset adverse effects associated with KW-0761 therapy.
authors: Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan. kojikato@intmed1.med.kyushu-u.ac.jp
authors: Koji
authors: K
authors: Kato
authors: Toshihiro
authors: T
authors: Miyamoto
authors: Akihiko
authors: A
authors: Numata
authors: Takashi
authors: T
authors: Nakaike
authors: Hideyo
authors: H
authors: Oka
authors: Ayano
authors: A
authors: Yurino
authors: Takuro
authors: T
authors: Kuriyama
authors: Yasuo
authors: Y
authors: Mori
authors: Satoshi
authors: S
authors: Yamasaki
authors: Tsuyoshi
authors: T
authors: Muta
authors: Katsuto
authors: K
authors: Takenaka
authors: Hiromi
authors: H
authors: Iwasaki
authors: Takanori
authors: T
authors: Teshima
authors: Koichi
authors: K
authors: Akashi
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage* / Q000009:adverse effects*; D001988:Bronchiolitis / Q000139:chemically induced*; D005260:Female; D006192:Haemophilus Infections / Q000139:chemically induced*; D006801:Humans; D000860:Hypoxia; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D054398:Receptors, CCR4; D013997:Time Factors
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C515354:CCR4 protein, human; D054398:Receptors, CCR4; C549035:mogamulizumab
references: Lancet. 1986 May 3;1(8488):1031-2
references: 2871307
references: J Clin Oncol. 2012 Mar 10;30(8):837-42
references: 22312108
references: J Clin Oncol. 2010 Mar 20;28(9):1591-8
references: 20177026
references: Blood. 1977 Sep;50(3):481-92
references: 301762
references: Eur Respir J. 2006 Oct;28(4):862-71
references: 17012632
references: J Infect Dis. 1992 Oct;166(4):943-4
references: 1527436
references: J Clin Oncol. 2009 Jan 20;27(3):453-9
references: 19064971
references: Lancet. 1989 Feb 25;1(8635):441
references: 2563817
references: Chest. 2001 Aug;120(2):602-7
references: 11502665
references: J Clin Oncol. 2007 Dec 1;25(34):5458-64
references: 17968021
references: Curr Opin Pulm Med. 1998 Mar;4(2):98-102
references: 9612672
references: Lancet. 1985 Aug 24;2(8452):407-10
references: 2863442
references: Acad Radiol. 2012 Aug;19(8):952-7
references: 22578413
references: Am J Hematol. 1989 Feb;30(2):86-90
references: 2643859
references: Nature. 1990 Nov 15;348(6298):245-8
references: 2146511
references: Cancer Res. 2006 Jun 1;66(11):5716-22
references: 16740709