title: Feasibility of tomotherapy to reduce cochlea radiation dose in patients with locally advanced nasopharyngeal cancer.
abstract: OBJECTIVE
  To evaluate the effectiveness of tomotherapy-based image-guided radiotherapy (IGRT) on the radiation dose to the cochlea in patients with nasopharyngeal cancer.
  
  
  METHODS
  A retrospective review of five patients undergoing concurrent chemoradiation with tomotherapy for locally advanced nasopharyngeal cancer was performed.
  
  
  RESULTS
  The mean dose to the right and left cochlea was 25 Gy and 35.3 Gy respectively, while the dose to the gross tumor ranged from 70 to 75 Gy. All patients had excellent clinical response to the treatment at a median follow-up of five months.
  
  
  CONCLUSIONS
  IGRT for head and neck cancer delivered by tomotherapy can significantly decrease the radiation dose to the cochlea without sacrificing target volume coverage.
authors: Radiation Oncology, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724-5081, USA. NamPhong.Nguyen@yahoo.com
authors: Nam P
authors: NP
authors: Nguyen
authors: Misty
authors: M
authors: Ceizyk
authors: Vincent
authors: V
authors: Vinh-Hung
authors: Thomas
authors: T
authors: Sroka
authors: Siyoung
authors: S
authors: Jang
authors: Rihan
authors: R
authors: Khan
authors: Angela
authors: A
authors: Locke
authors: Gabby
authors: G
authors: Albala
authors: Christina
authors: C
authors: Truong
authors: Juan
authors: J
authors: Godinez
authors: Richard
authors: R
authors: Vo
authors: Lexie
authors: L
authors: Smith-Raymond
mesh_terms: D000368:Aged; D002277:Carcinoma; D059248:Chemoradiotherapy; D003051:Cochlea / Q000528:radiation effects*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D011881:Radiotherapy, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D016896:Treatment Outcome