title: Elevated intraocular pressure is associated with metabolic syndrome in postmenopausal women: the Korean National Health and Nutrition Examination Survey.
abstract: OBJECTIVE
  This study aimed to investigate the association between intraocular pressure and metabolic syndrome according to menopause status in nonglaucomatous Korean women.
  
  
  METHODS
  We examined the relationship between intraocular pressure and metabolic syndrome in 4,524 nonglaucomatous Korean women (2,866 premenopausal women and 1,658 postmenopausal women) who participated in the 2008 Korean National Health and Nutrition Examination Survey. Multivariate linear regression analysis was used to assess the relationship between metabolic syndrome and intraocular pressure after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, hypertension medication, and diabetes medication according to menopause status in women.
  
  
  RESULTS
  The prevalence of metabolic syndrome was 5.4% for premenopausal women and 28.0% for postmenopausal women. The mean intraocular pressure gradually increased in accordance with the increasing number of components for metabolic syndrome in postmenopausal women (P = 0.002), but not in premenopausal women (P = 0.387). In multivariate regression analysis, intraocular pressure was significantly associated with metabolic syndrome in postmenopausal women (P = 0.015) after adjusting for confounding variables, but not in premenopausal women (P = 0.940).
  
  
  CONCLUSIONS
  Intraocular pressure was associated with metabolic syndrome in postmenopausal women, but not in premenopausal women. These findings suggest that intraocular pressure changes may be linked to metabolic syndrome in postmenopausal women.
authors: Department of Family Medicine, CHA University College of Medicine, Seoul, Republic of Korea.
authors: Byoung-Jin
authors: BJ
authors: Park
authors: Jin-Oh
authors: JO
authors: Park
authors: Hee-Taik
authors: HT
authors: Kang
authors: Yong-Jae
authors: YJ
authors: Lee
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D016014:Linear Models; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D009749:Nutrition Surveys; D017698:Postmenopause; D017697:Premenopause; D056910:Republic of Korea
chemical_list: D001786:Blood Glucose