title: Investigation of potential injectable polymeric biomaterials for bone regeneration.
abstract: This article reviews the potential injectable polymeric biomaterial scaffolds currently being investigated for application in bone tissue regeneration. Two types of injectable biomaterial scaffolds are focused in this review, including injectable microspheres and injectable gels. The injectable microspheres section covers several polymeric materials, including poly(L-lactide-co-glycolide)-PLGA, poly(propylene fumarate), and chitosan. The injectable gel section covers alginate gels, hyaluronan hydrogels, poly(ethylene-glycol)-PEG hydrogels, and PEG-PLGA copolymer hydrogels. This review focuses on the effect of cellular behavior in vitro and in vivo in terms of material properties of polymers, such as biodegradation, biocompatibility, porosity, microsphere size, and cross-linking nature. Injectable polymeric biomaterials offer a major advantage for orthopedic applications by allowing the ability to use noninvasive or minimally invasive treatment methods. Therefore, combining injectable polymeric biomaterial scaffolds with cells have a significant potential to treat orthopedic bone defects, including spine fusion, and craniofacial and periodontal defects.
authors: Department of Orthopaedic Surgery, The University of Toledo, College of Medicine, Toledo, Ohio 43614, USA.
authors: Michael B
authors: MB
authors: Dreifke
authors: Nabil A
authors: NA
authors: Ebraheim
authors: Ambalangodage C
authors: AC
authors: Jayasuriya
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D001861:Bone Regeneration; D005782:Gels / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007267:Injections; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D011108:Polymers
references: J Mech Behav Biomed Mater. 2011 Oct;4(7):1219-27
references: 21783130
references: Tissue Eng Part A. 2009 Aug;15(8):2299-307
references: 19292677
references: J Tissue Eng Regen Med. 2012 Aug;6(8):614-21
references: 21916016
references: Macromol Biosci. 2006 Aug 7;6(8):623-33
references: 16881042
references: J Biomed Mater Res A. 2012 Dec;100(12):3392-9
references: 22767519
references: Biomacromolecules. 2010 May 10;11(5):1160-8
references: 20345129
references: Tissue Eng. 2006 Jul;12(7):1753-61
references: 16889506
references: Clin Orthop Relat Res. 1995 Apr;(313):115-9
references: 7641468
references: Biomaterials. 2012 Jun;33(19):4801-9
references: 22463934
references: J Orthop Res. 2008 Apr;26(4):539-46
references: 17960653
references: J Am Chem Soc. 2009 Jul 1;131(25):8781-3
references: 19499915
references: J Biomed Mater Res A. 2010 Jun 15;93(4):1280-8
references: 19827109
references: Adv Mat Res. 2011;383-390:4065-4069
references: 25477727
references: J Biomed Mater Res B Appl Biomater. 2008 Feb;84(2):493-502
references: 17635038
references: J Biomed Mater Res A. 2009 Sep 1;90(3):863-73
references: 18615467
references: J Biomed Mater Res. 2002 May;60(2):241-51
references: 11857430
references: J Biomed Mater Res A. 2010 Feb;92(2):451-62
references: 19191316
references: Bone. 1993 May-Jun;14(3):575-80
references: 8363908
references: Biomed Mater. 2012 Jun;7(3):035002
references: 22358865
references: Tissue Eng Part A. 2008 Apr;14(4):539-47
references: 18352826
references: Injury. 2005 Apr;36(4):489-94
references: 15755429
references: J Biomed Mater Res A. 2006 Apr;77(1):103-11
references: 16392139
references: Biomaterials. 2011 Oct;32(30):7503-13
references: 21757229
references: Cell Tissue Res. 2010 Sep;341(3):359-70
references: 20680346
references: J Tissue Eng Regen Med. 2008 Jan;2(1):43-9
references: 18361482
references: Biomaterials. 2010 Sep;31(25):6502-10
references: 20570346
references: Biomacromolecules. 2011 Apr 11;12(4):1290-7
references: 21361277
references: Tissue Eng Part A. 2009 Sep;15(9):2571-9
references: 19309240
references: Ann Biomed Eng. 2010 Mar;38(3):632-9
references: 20049636
references: Bone. 2009 Jul;45(1):42-51
references: 18708174
references: J Biomater Sci Polym Ed. 1997;8(11):893-904
references: 9342654
references: Anat Rec. 2001 Aug 1;263(4):342-9
references: 11500810
references: J Biomed Mater Res A. 2009 Dec 15;91(4):1111-8
references: 19107794
references: Mol Ther. 2007 Jun;15(6):1189-94
references: 17406344
references: Acta Biomater. 2011 Nov;7(11):3829-40
references: 21742067
references: J Phys Chem B. 2009 Dec 31;113(52):16518-25
references: 19947637
references: Macromol Rapid Commun. 2010 Jul 1;31(13):1175-80
references: 21590872
references: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3305-10
references: 20133731
references: Biomacromolecules. 2002 May-Jun;3(3):511-6
references: 12005522
references: Tissue Eng Part A. 2010 Nov;16(11):3457-66
references: 20666585
references: Haematol Blood Transfus. 1980;25:19-29
references: 7021339
references: Carbohydr Res. 2005 Oct 31;340(15):2403-10
references: 16109386
references: Pharm Res. 2009 Feb;26(2):422-30
references: 18979188
references: Endocr Dev. 2009;16:32-48
references: 19494659
references: Biomaterials. 2010 Dec;31(34):9092-105
references: 20800893
references: Tissue Eng Part A. 2011 Nov;17(21-22):2713-22
references: 21682547
references: Drug Dev Ind Pharm. 2008 May;34(5):492-8
references: 18473231
references: Biomaterials. 2010 Jun;31(16):4457-66
references: 20202682
references: Hosp Med. 2003 Apr;64(4):205-9
references: 12731131
references: Open Orthop J. 2008 Apr 25;2:66-78
references: 19506701
references: Curr Top Med Chem. 2008;8(4):354-64
references: 18393897
references: J Biomed Mater Res. 2002 Aug;61(2):169-79
references: 12061329
references: Biomaterials. 2005 Oct;26(30):5983-90
references: 15894370
references: J Biomed Mater Res. 2000 May;50(2):171-7
references: 10679681
references: Plast Reconstr Surg. 2010 May;125(5):1383-1392
references: 20440158
references: J Tissue Eng Regen Med. 2010 Oct;4(7):532-42
references: 20872740
references: J Biomed Mater Res. 2000 May;50(2):101-9
references: 10679672
references: J Biomed Mater Res A. 2010 Mar 1;92(3):1131-8
references: 19322877
references: Int J Nanomedicine. 2006;1(4):541-5
references: 17722285
references: Tissue Eng Part A. 2008 Jul;14(7):1173-82
references: 18593356
references: J Biomed Mater Res A. 2007 Nov;83(2):323-31
references: 17437304
references: J Biomed Mater Res A. 2009 Apr;89(1):248-54
references: 18464255
references: J Biomed Mater Res A. 2009 Dec 15;91(4):975-84
references: 19097152
references: Biomaterials. 2004 Aug;25(18):3973-81
references: 15046887
references: Biomed Mater. 2009 Oct;4(5):055006
references: 19779252
references: Tissue Eng Part A. 2009 Mar;15(3):587-94
references: 18925831
references: J Control Release. 2011 Jun 10;152(2):232-40
references: 21315118
references: J Biomed Sci Eng. 2011 May 17;4(5):383-390
references: 25289115
references: J Drug Target. 2010 May;18(4):321-31
references: 20199172
references: J Biomed Mater Res A. 2010 Jun 1;93(3):941-53
references: 19708075
references: Semin Cell Dev Biol. 2001 Apr;12(2):79-87
references: 11292373
references: Biomaterials. 2005 Jun;26(16):3215-25
references: 15603816
references: J Control Release. 2007 May 14;119(1):94-101
references: 17331613
references: Biomaterials. 2011 Aug;32(22):5241-51
references: 21507479
references: J Tissue Eng Regen Med. 2011 Nov;5(10):806-14
references: 22002924
references: Orthop Clin North Am. 2010 Jan;41(1):75-84; table of contents
references: 19931055
references: Biomaterials. 2005 Oct;26(29):5872-8
references: 15949553
references: J Mater Sci Mater Med. 2005 Jun;16(6):515-9
references: 15928866
references: J Biomed Mater Res A. 2008 Jun 15;85(4):1114-9
references: 17941027
references: J Tissue Eng Regen Med. 2008 Aug;2(6):378-80
references: 18615778
references: J Biomed Mater Res A. 2008 Jun 1;85(3):747-56
references: 17896763
references: Eur J Pharm Biopharm. 2008 Jan;68(1):67-73
references: 17888640
references: J Biomed Mater Res A. 2004 Aug 1;70(2):283-92
references: 15227673
references: J Tissue Eng Regen Med. 2010 Jul;4(5):340-8
references: 20033925
references: Biotechnol Adv. 2008 Jan-Feb;26(1):1-21
references: 17884325
references: J Biomed Mater Res A. 2005 Sep 15;74(4):533-44
references: 16041795
references: J Orthop Sci. 2006 Oct;11(5):497-504
references: 17013739
references: J Biomed Mater Res. 2001 Aug;56(2):228-33
references: 11340593
references: Int J Pediatr Otorhinolaryngol. 2008 Nov;72(11):1627-32
references: 18786734
references: Biomaterials. 2007 Apr;28(10):1830-7
references: 17208295
references: J Biomed Mater Res A. 2012 Jan;100(1):171-9
references: 22009709
references: J Control Release. 2005 Aug 18;106(1-2):62-75
references: 15922472
references: Int J Mol Sci. 2009 Jul 03;10(7):2972-85
references: 19742179
references: Eur J Pharm Sci. 2010 Jan 31;39(1-3):59-67
references: 19895885