title: [The role of gastric pH and tissue hypoxia in formation of gastroduodenal zone mucose changes in heartsurgical patients].
abstract: The estimation of gastric contents pH and gastroduodenal zone mucous membrane condition based on the fibrogastroduodenoscopy data of40 patients who were examined and received proton pump inhibitors in the postoperative period after heart surgical intervention. It was estimated, that acidic peptic aggression and tissue hypoxia are important factors for occurrence of destructive gastroduodenal membrane changes in heart surgery patients. The differences of antisecretory activity of proton pump inhibitors are revealed, so it was useful to use analogous pH-test using in the intensive care unit. The preferences of original omeprazole for intravenous use with it antisecretory effect were marked in comparison with generic omeprazole: the stability of gastric contents pH more than 4,0 was in 100%, more than 6,0 was in 86% of the time for original drug and in 84% and in 27% for generic drug respectively. It is also demonstrated, that cardiotonic drugs using and prosthesis of cardiac valves are additional risk factors of gastroduodenal membrane destruction, independent of acidic aggression.
authors: E A
authors: EA
authors: Sorokina
authors: A A
authors: AA
authors: Fokin
authors: V A
authors: VA
authors: Akhmedov
authors: V V
authors: VV
authors: Safechuk
authors: S A
authors: SA
authors: Kopeĭkin
authors: T V
authors: TV
authors: Trubina
mesh_terms: D000368:Aged; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D007362:Intensive Care Units; D007413:Intestinal Mucosa / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*; D011182:Postoperative Care / Q000379:methods; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D009853:Omeprazole