title: Respiratory syncytial virus: current progress in  vaccine development.
abstract: Respiratory syncytial virus (RSV) is the etiological agent for a serious lower respiratory tract disease responsible for close to 200,000 annual deaths worldwide.  The first infection is generally most severe, while re-infections usually associate with a milder disease. This observation and the finding that re-infection risks are inversely associated with neutralizing antibody titers suggest that immune responses generated toward a first RSV exposure can significantly reduce morbidity and mortality  throughout life. For more than half a century, researchers have endeavored to design a vaccine for RSV that can mimic or improve upon natural protective immunity without adverse events. The virus is herein described together with the hurdles that must be overcome to develop a vaccine and some current vaccine development approaches.
authors: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Rajeev.rudraraju@stjude.org
authors: Rajeev
authors: R
authors: Rudraraju
authors: Bart G
authors: BG
authors: Jones
authors: Robert
authors: R
authors: Sealy
authors: Sherri L
authors: SL
authors: Surman
authors: Julia L
authors: JL
authors: Hurwitz
mesh_terms: D000818:Animals; D006801:Humans; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000517:prevention & control*; D022261:Respiratory Syncytial Virus Vaccines / Q000276:immunology; D012136:Respiratory Syncytial Viruses / Q000276:immunology* / Q000502:physiology
chemical_list: D022261:Respiratory Syncytial Virus Vaccines
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