title: Effectiveness of preoperative plasmapheresis in a pregnancy complicated by hyperthyroidism and anti-thyroid drug-associated angioedema.
abstract: Hyperthyroidism is not a rare entity in pregnancy and 85% of these cases attributed to Graves' disease (GD). There is no therapeutic modality for GD considered as totally safe in pregnancy. Fetal and neonatal risks of maternal hyperthyroid disease are related to the hyperthyroidism itself and/or to the medical treatment of the disease. There are no data supporting an association between congenital anomalies in the fetus and propylthiouracil (PTU). Hepatotoxicity, cytopenias--especially agranulocytosis and quite rarely, angioedema, may be seen as side effects of PTU. In this case report, we examine an instance of Graves' hyperthyroidism diagnosed during pregnancy. In this case, a serious side effect during anti-thyroid drug usage was encountered, eventually resulting in surgery in the second trimester. This intervention was assisted by the use of plasmapheresis to obtain rapid normalization of serum thyroid hormone levels.
authors: Department of Internal Medicine, Division of Endocrinology and Metabolism, Trakya University, Edirne, Turkey.
authors: B Ekiz
authors: BE
authors: Bilir
authors: N Soysal
authors: NS
authors: Atile
authors: O
authors: O
authors: Kirkizlar
authors: Y
authors: Y
authors: Kömürcü
authors: S
authors: S
authors: Akpinar
authors: A
authors: A
authors: Sezer
authors: M
authors: M
authors: Demir
authors: S
authors: S
authors: Hekimoğlu
mesh_terms: D000799:Angioedema / Q000139:chemically induced / Q000628:therapy*; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006111:Graves Disease / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D010956:Plasmapheresis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D011300:Preoperative Care; D011441:Propylthiouracil / Q000009:adverse effects*; D013965:Thyroidectomy; D055815:Young Adult
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil