title: Different Mid-Term Prognostic Predictors of Major Adverse Events in Diabetic and Nondiabetic Peripheral Artery Disease Presenting With Critical Limb Ischemia.
abstract: We compared midterm prognostic predictors of peripheral artery disease (PAD) with or without diabetes mellitus (DM) presenting with critical lower limb ischemia (CLI). A total of 172 patients with PAD (109 DM; 63 non-DM) were enrolled. The major adverse events (MAEs) were death or amputation. The diabetic group had a higher MAE rate (39% vs 22%, P = .042) with a mean follow-up duration of 30 ± 19 months. In a multivariate binary logistic regression analysis, revascularization (odds ratio = 0.289, P = .006) and higher serum cholesterol (odds ratio=0.988, P = .027) predicted a lower MAE rate in the DM group. In contrast, the presence of severe chronic kidney disease (stage 4 or 5, odds ratio = 5.238, P = .025) was a positive predictor of MAEs in the nondiabetic group. In conclusion, the prognostic predictors of MAE in diabetic and nondiabetic patients with PAD and CLI were different.
authors: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan Department of Medicine, Cardiovascular Research Center and Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan Department of Medicine, Chung Shan Medical University, Taichung, Taiwan Department of Medicine, China Medical University, Taichung, Taiwan.
authors: Kae-Woei
authors: KW
authors: Liang
authors: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
authors: Hsun-Nan
authors: HN
authors: Kuo
authors: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan Department of Medicine, Cardiovascular Research Center and Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan.
authors: Wen-Lieng
authors: WL
authors: Lee
authors: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan Department of Medicine, Cardiovascular Research Center and Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan.
authors: Tsun-Jui
authors: TJ
authors: Liu
authors: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan Department of Medicine, Chung Shan Medical University, Taichung, Taiwan Department of Medicine, China Medical University, Taichung, Taiwan Department of Life Science, Tung-Hai University, Taichung, Taiwan.
authors: Wei-Wen
authors: WW
authors: Lin
authors: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan Department of Medicine, Cardiovascular Research Center and Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan.
authors: Chen-Rong
authors: CR
authors: Tsao
authors: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan Department of Medicine, Cardiovascular Research Center and Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan.
authors: Chih-Tai
authors: CT
authors: Ting
authors: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan Department of Medicine, Cardiovascular Research Center and Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan Department of Medicine, Chung Shan Medical University, Taichung, Taiwan Department of Medicine, China Medical University, Taichung, Taiwan wky@vghtc.gov.tw.
authors: Kuo-Yang
authors: KY
authors: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D016009:Chi-Square Distribution; D016638:Critical Illness; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D057510:Endovascular Procedures / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D023821:Limb Salvage; D016015:Logistic Models; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects* / Q000401:mortality
keywords: chronic kidney disease; critical limb ischemia; diabetes mellitus; peripheral artery disease