title: MicroRNAs in platelet physiology and pathology.
abstract: MicroRNAs (miRNAs), highly conserved, short (approx. 22 nucleotides) non-coding RNAs, exhibit a fine-tune control over gene expression by complementary sequence binding and translational repression of protein coding mRNA transcripts. Recently, the role of miRNAs has been increasingly investigated in various physiological or pathophysiological events. Circulating platelets are crucial for coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. Anucleate platelets lack genomic DNA but inherit diverse array of functional coding or non-coding RNAs and translational machinery from their parent cells - megakaryocytes enabling activated platelets to synthesize proteins which suggests the possibility of post transcriptional gene regulation in platelets. Expression of functionally active miRNAs in platelets changes during platelet activation indicating a role in platelet biology. Here, we present a review on recently identified platelet miRNAs and their role in platelet physiology that is essential for maintaining haemostasis.
authors: Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. thum.thomas@mh-hannover.de
authors: S
authors: S
authors: Dangwal
authors: T
authors: T
authors: Thum
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000235:genetics*; D001792:Blood Platelets / Q000502:physiology*; D005786:Gene Expression Regulation / Q000235:genetics*; D006487:Hemostasis / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D035683:MicroRNAs / Q000502:physiology*; D015539:Platelet Activation / Q000235:genetics*
chemical_list: D035683:MicroRNAs