title: [Effect of succinate-containing medications on hepatic structural changes in acute experimental cholecystitis].
abstract: Histological and electron microscopic changes in the hepatic structure were studied in animals with acute experimental cholecystitis. The administration of the succinate-containing drugs reamberin and mexidole decreased the magnitude of morphological changes in the liver tissue. Morphometric examination revealed that reamberin versus mexidole showed a high efficacy in reducing the area of hepatocytic necrosis.
authors: S V
authors: SV
authors: Iakubovskiĭ
authors: S L
authors: SL
authors: Anishchenko
authors: A A
authors: AA
authors: Emel'ianova
authors: L D
authors: LD
authors: Chaĭka
mesh_terms: D000818:Animals; D041881:Cholecystitis, Acute / Q000188:drug therapy / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009336:Necrosis / Q000188:drug therapy / Q000473:pathology; D013386:Succinates / Q000008:administration & dosage*; D019802:Succinic Acid / Q000008:administration & dosage*
chemical_list: C549374:Reamberin; D013386:Succinates; D008536:Meglumine; D019802:Succinic Acid