title: Microalbuminuria is independently associated with arterial stiffness and vascular inflammation but not with carotid intima-media thickness in patients with newly diagnosed type 2 diabetes or essential hypertension.
abstract: The association between microalbuminuria (MAU) and the indices of macrovascular complication in patients with newly diagnosed type 2 diabetes (D) or essential hypertension (H) was evaluated. Total 446 patients were classified into four groups according to the urinary albumin-to-creatinine ratio: MAU-D (n = 104), normoalbuminuria (NAU)-D (n = 114), MAU-H (n = 116), and NAU-H (n = 112). The indices of macrovascular complication including arterial stiffness evaluated by pulse-wave-velocity (PWV), carotid intima-media thickness (IMT), and vascular inflammation marked by high-sensitivity C-reactive protein (hsCRP) were assessed. PWV, IMT, and hsCRP were higher in patients with MAU than in those with NAU in both diabetes and hypertension groups. In both MAU-D and MAU-H groups, PWV and hsCRP levels were positively correlated with MAU level (MAU-D: r = 0.47, 0.41, MAU-H: r = 0.36, 0.62, respectively, P < 0.05). Additionally, PWV and hsCRP were independent factors predicting MAU (diabetes group: OR 1.85, 1.54, hypertension group: OR 1.38, 1.51, respectively, P < 0.001), but not IMT. MAU is independently associated with arterial stiffness and vascular inflammation but not with IMT in patients with newly diagnosed type 2 diabetes or essential hypertension, which emphasizes the importance of proactive clinical investigations for atherosclerotic complications in patients with MAU, even in newly diagnosed diabetes or hypertension.
authors: Department of Internal Medicine, The Catholic University of Korea, Incheon, Korea.
authors: Dong Il
authors: DI
authors: Shin
authors: Ki-Bae
authors: KB
authors: Seung
authors: Hye Eun
authors: HE
authors: Yoon
authors: Byung-Hee
authors: BH
authors: Hwang
authors: Suk Min
authors: SM
authors: Seo
authors: Seok Joon
authors: SJ
authors: Shin
authors: Pum-Joon
authors: PJ
authors: Kim
authors: Kiyuk
authors: K
authors: Chang
authors: Sang Hong
authors: SH
authors: Baek
mesh_terms: D000419:Albuminuria; D019540:Area Under Curve; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology; D059168:Carotid Intima-Media Thickness; D003404:Creatinine / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D059289:Vascular Stiffness
chemical_list: D002097:C-Reactive Protein; D003404:Creatinine
keywords: Albuminuria; Carotid Intima-Media Thickness; Inflammation; Vascular Stiffness
references: Am J Hypertens. 2009 Oct;22(10):1041-7
references: 19629049
references: J Clin Hypertens (Greenwich). 2010 Jun;12(6):422-30
references: 20591087
references: Diabetes Care. 2011 Jun;34(6):1403-5
references: 21515840
references: Diabetes Care. 1997 Jul;20(7):1183-97
references: 9203460
references: Nephron Exp Nephrol. 2011;119 Suppl 1:e6-10
references: 21832857
references: J Intern Med. 2004 Jul;256(1):22-9
references: 15189362
references: J Atheroscler Thromb. 2011;18(9):744-52
references: 21597231
references: J Hypertens. 2011 Nov;29(11):2091-8
references: 21881520
references: Nephron. 1976;16(1):31-41
references: 1244564
references: Kidney Blood Press Res. 2010;33(2):111-8
references: 20431302
references: J Korean Med Sci. 2010 Jul;25(7):1045-52
references: 20592897
references: Circ J. 2010 Jan;74(1):24-33
references: 19920359
references: Kidney Int. 1999 Dec;56(6):2214-9
references: 10594797
references: Intern Med. 2012;51(6):537-43
references: 22449659
references: Am J Cardiol. 2008 Feb 1;101(3):401-6
references: 18237609
references: J Clin Endocrinol Metab. 2010 Nov;95(11):5122-8
references: 20719840
references: J Korean Med Sci. 2012 Jul;27(7):784-7
references: 22787375
references: J Am Coll Cardiol. 2008 Apr 22;51(16):1573-8
references: 18420100
references: JAMA. 2003 May 21;289(19):2560-72
references: 12748199
references: Diabet Med. 2005 Nov;22(11):1558-65
references: 16241922
references: J Hypertens. 2012 May;30(5):940-7
references: 22495135
references: Am J Hypertens. 2006 May;19(5):462-6
references: 16647614
references: Am J Hypertens. 2008 Apr;21(4):413-8
references: 18369360
references: Diabetes Metab J. 2011 Dec;35(6):571-7
references: 22247898
references: J Nephrol. 2007 Mar-Apr;20(2):204-11
references: 17514625
references: Am J Hypertens. 2004 Oct;17(10):986-93
references: 15485765
references: J Korean Med Sci. 2011 Sep;26(9):1185-90
references: 21935274
references: Atherosclerosis. 2011 Sep;218(1):13-8
references: 21763654
references: Int Angiol. 2002 Mar;21(1):70-7
references: 11941277