title: Organocatalytic direct asymmetric crossed-aldol reactions of acetaldehyde in aqueous media.
abstract: A new type of diarylprolinol-based catalyst, which contains a dioctylamino group in the presence of a newly developed ionic liquid supported (ILS) benzoic acid as cocatalyst, is shown to be an effective catalytic system for the asymmetric direct crossed-aldol reaction of acetaldehyde in aqueous media using brine. For the reactions studied, the catalyst loading could be reduced to 5 mol %; high yields (up to 97%) and high enantioselectivities (up to 92% ee) were also achieved for a wide variety of aromatic aldehyde.
authors: Department of Chemistry, Texas A&M University-Commerce, Commerce, Texas 75429-3011, United States.
authors: Yupu
authors: Y
authors: Qiao
authors: Qiankun
authors: Q
authors: Chen
authors: Sirong
authors: S
authors: Lin
authors: Bukuo
authors: B
authors: Ni
authors: Allan D
authors: AD
authors: Headley