title: [Neuro-skeletal biology and its importance for clinical osteology].
abstract: Bone remodeling is determined by function of two basic cell forms--bone resorbing osteoclasts and bone formation activating osteoblasts. Both cells are under control of a variety of endogenic and environmental factors, which ensure balance between bone resorption and bone formation. This article reviews the neuro-hormonal factors with osteoanabolic (central isoform of serotonin, melatonin, cannabinoids, beta 1 adrenergic system, oxytocin, ACTH and TSH) or osteocatabolic effects (neuropeptide Y, neuromedin U, beta2 adrenergic system). The dual effects of the beta-adrenergic system, serotonin and leptin are also discussed. The goal of studies focused on neuro-skeletal interaction is to synthesize new molecules, which can modify osteo-anabolic or osteo-catabolic pathways.
authors: Endokrinologický ústav, Praha. izofkova@endo.cz
authors: I
authors: I
authors: Zofková
mesh_terms: D016723:Bone Remodeling / Q000502:physiology*; D002186:Cannabinoids / Q000378:metabolism; D006801:Humans; D009478:Neuropeptide Y / Q000502:physiology; D010006:Osteoblasts / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D059166:Osteology; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology; D012701:Serotonin / Q000502:physiology
chemical_list: D002186:Cannabinoids; D009478:Neuropeptide Y; D018343:Receptors, Adrenergic, beta-2; D012701:Serotonin