title: [Metabolic alteration in healthy men with first degree type 2 diabetic relatives].
abstract: BACKGROUND
  The recognition of prediabetic patients with the genetic risk of type 2 diabetes is very important as prediabetes is the last stage when manifestation of diabetes could be prevented by life style modification or drug intervention. This suggests the need for diagnostic processes to trace the risk of patients in time.
  
  
  OBJECTIVE
  The authors looked for metabolic differences between age and BMI in adjusted healthy men with or without first degree type 2 diabetic relatives.
  
  
  METHODS
  The study included 73 healthy men (21 with and 52 without) first-degree relatives with type 2 diabetes.
  
  
  RESULTS
  Total body and muscle tissue glucose utilization, glucose tolerance did not differ between the two groups, but free fatty acid levels were not suppressed by glucose load in subjects with diabetic relatives. In addition the body fat content, leptin and IL-6 levels were higher, while adiponectin and the free fatty acid/adiponectin ratio were significantly lover in healthy men with diabetic relatives. In this group HDL cholesterol, and the large buoyant LDL fraction were lower whereas the high density LDL - small molecular lipid fraction was higher than those measured in subjects without diabetic relatives.
  
  
  CONCLUSIONS
  These data suggest that deteriorations of insulin sensitivity and glucose tolerance is preceded by disturbances of fatty acid metabolism. The observed alteration in free fatty acid/adiponectin ratio, and/or the absence of free fatty acid suppression during glucose tolerance tests could be a screening tool for diabetes risk among men.
authors: DRC Gyógyszervizsgáló Központ Kft. Balatonfüred Ady Endre u. 12. 8230. jozsef.pauer@drc.hu
authors: József
authors: J
authors: Pauer
authors: Attila
authors: A
authors: Fék
authors: Barbara
authors: B
authors: Buday
authors: Botond
authors: B
authors: Literáti-Nagy
authors: Péter
authors: P
authors: Pach
authors: Márta
authors: M
authors: Vitai
authors: Eva
authors: E
authors: Péterfai
authors: László
authors: L
authors: Korányi
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2; D005190:Family; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D008078:Cholesterol, LDL; D005230:Fatty Acids, Nonesterified; D015850:Interleukin-6; D020738:Leptin