title: The development of a new desensitising mouthwash containing arginine, PVM/MA copolymer, pyrophosphates, and sodium fluoride--a hydraulic conductance study.
abstract: OBJECTIVE
  To investigate the ability of a novel mouthwash comprised of 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride in an alcohol-free base (Pro-Argin™ Mouthwash Technology) to reduce dentine permeability.
  
  
  METHODS
  Hydraulic conductance was used to assess the dentine permeability effects of the arginine mouthwash. Aqueous solutions containing arginine and PVM/MA copolymer were studied in the initial stage of the method development. The acid resistance was tested with a cola drink challenge. Finally, a blinded study was carried out to determine the occlusion of the arginine mouthwash in comparison to a negative control mouthwash.
  
  
  RESULTS
  Dentine discs treated with the arginine mouthwash showed an average fluid reduction of 42%, which was statistically, significantly better than the fluid reduction for the negative control mouthwash. In addition, experiments using simple solutions of arginine and PVM/MA copolymer, alone and in combination, demonstrated that the combination of the two was required to provide a relevant occlusion benefit. Finally, the occlusion provided by the arginine mouthwash was maintained after exposure to an acid challenge.
  
  
  CONCLUSIONS
  The exclusive combination of ingredients in the arginine mouthwash has been proven to be efficacious in decreasing dentine fluid flow as measured by hydraulic conductance. The new mouthwash works by occlusion, due to the unique combination of arginine, PVM/MA copolymer and pyrophosphates.
authors: Colgate-Palmolive Technology Center, 909 River Road, Piscataway, NJ 08855-1343, USA. sarita_mello@colpal.com
authors: Sarita V
authors: SV
authors: Mello
authors: Evangelia
authors: E
authors: Arvanitidou
authors: Mark
authors: M
authors: Vandeven
mesh_terms: D001120:Arginine / Q000138:chemical synthesis*; D002119:Calcium Carbonate / Q000138:chemical synthesis*; D057133:Dentin Desensitizing Agents / Q000138:chemical synthesis*; D011756:Diphosphates / Q000138:chemical synthesis; D004338:Drug Combinations; D004339:Drug Compounding; D005459:Fluorides / Q000138:chemical synthesis*; D006801:Humans; D057446:Hydrodynamics; D008298:Maleates / Q000138:chemical synthesis*; D009067:Mouthwashes / Q000138:chemical synthesis*; D010710:Phosphates / Q000138:chemical synthesis*; D011095:Polyethylenes / Q000138:chemical synthesis*; D012969:Sodium Fluoride / Q000138:chemical synthesis
chemical_list: D057133:Dentin Desensitizing Agents; D011756:Diphosphates; D004338:Drug Combinations; D008298:Maleates; D009067:Mouthwashes; D010710:Phosphates; D011095:Polyethylenes; C585805:pro-argin; C107241:diphosphoric acid; D012969:Sodium Fluoride; C043105:poly(methyl vinyl ether-co-maleic anhydride); D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides