title: Pilot study on the feasibility of PET/CT lymphoscintigraphy with 89Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients.
abstract: With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs.
  
  
  METHODS
  In this study, the clinical feasibility of PET/CT lymphoscintigraphy using (89)Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of (89)Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using (99m)Tc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of (89)Zr-nanocolloidal albumin.
  
  
  RESULTS
  Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/CT was able to identify additional foci near the primary tumor.
  
  
  CONCLUSIONS
  This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using (89)Zr-nanocolloidal albumin is feasible.
authors: Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.
authors: Derrek A
authors: DA
authors: Heuveling
authors: Annelies
authors: A
authors: van Schie
authors: Danielle J
authors: DJ
authors: Vugts
authors: N Harry
authors: NH
authors: Hendrikse
authors: Maqsood
authors: M
authors: Yaqub
authors: Otto S
authors: OS
authors: Hoekstra
authors: K Hakki
authors: KH
authors: Karagozoglu
authors: C René
authors: CR
authors: Leemans
authors: Guus A M S
authors: GA
authors: van Dongen
authors: Remco
authors: R
authors: de Bree
mesh_terms: D005240:Feasibility Studies; D006801:Humans; D008207:Lymphatic Metastasis; D061305:Lymphoscintigraphy / Q000379:methods*; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D064847:Multimodal Imaging / Q000379:methods*; D049329:Nanostructures; D009367:Neoplasm Staging; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D011868:Radioisotopes; D013668:Technetium Tc 99m Aggregated Albumin / Q000737:chemistry; D014057:Tomography, X-Ray Computed; D015040:Zirconium
chemical_list: D011868:Radioisotopes; D013668:Technetium Tc 99m Aggregated Albumin; D015040:Zirconium