title: MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation.
abstract: A recent work of Iliopoulos et al published in Cell highlighted a circuit orchestrated by microRNAs (miRNAs) that results in liver tumorigenesis and inflammation. This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4α transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation. These promising data support the use of miRNA mimics or inhibitors as potent therapeutic approaches in liver cancer.
authors: Institut Cochin, INSERM, U1016, 75014 Paris, France. angelique.gougelet@inserm.fr
authors: Angélique
authors: A
authors: Gougelet
authors: Sabine
authors: S
authors: Colnot
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D025461:Feedback, Physiological; D015972:Gene Expression Regulation, Neoplastic; D006505:Hepatitis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051557:Hepatocyte Nuclear Factor 4 / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D035683:MicroRNAs / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D051557:Hepatocyte Nuclear Factor 4; D035683:MicroRNAs; D050796:STAT3 Transcription Factor
keywords: Hepatocellular oncogenesis; Hepatocyte nuclear factor-4α; Interleukin-6; MicroRNA; Signal transducer and activator of transcription 3
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