title: Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review.
abstract: Trichosanthin (TCS) as a midterm abortifacient medicine has been used clinically in traditional Chinese medicine for centuries. Additionally, TCS manifests a host of pharmacological properties, for instance, anti-HIV and anti-tumor activities. TCS has been reported to inhibit cell growth of a diversity of cancers, including cervical cancer, choriocarcinoma, and leukemia/lymphoma, etc. This article purported to review the various anti-tumor activities of TCS and the mechanism of apoptosis it induced in these tumor cells. These research progresses provide an insight into cancer research and treatment as well as disclose new pharmacological properties of the ancient but popular Chinese medicine.
authors: School of Medicine, Shenzhen University, Shenzhen, China. shaou@szu.edu.cn
authors: Ou
authors: O
authors: Sha
authors: Junfei
authors: J
authors: Niu
authors: Tzi-Bun
authors: TB
authors: Ng
authors: Eric Yu-Pang
authors: EY
authors: Cho
authors: Xiaoyuan
authors: X
authors: Fu
authors: Wenqi
authors: W
authors: Jiang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D008516:Medicine, Chinese Traditional; D029778:Trichosanthes / Q000737:chemistry; D015978:Trichosanthin / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D015978:Trichosanthin
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