title: Replication of European rheumatoid arthritis loci in a Pakistani population.
abstract: OBJECTIVE
  Genetic studies have identified several rheumatoid arthritis (RA) susceptibility loci in European-derived populations. The same biological pathways may be involved in determining the RA risk in different population groups. We sought to replicate the association of 33 single-nucleotide polymorphisms (SNP) from 31 RA susceptibility loci confirmed among Europeans in a unique Pakistani population.
  
  
  METHODS
  We genotyped 33 SNP in a sample of 366 Pakistanis that comprised related and unrelated cases and controls. Genotyping was performed using TaqMan assays and the results were analyzed with family case-control software.
  
  
  RESULTS
  Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP.
  
  
  CONCLUSIONS
  Our observations suggest that a number of RA susceptibility loci and related pathways are shared across different populations.
authors: Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST), Islamabad, Pakistan.
authors: Syed Fazal
authors: SF
authors: Jalil
authors: Attya
authors: A
authors: Bhatti
authors: F Yesim
authors: FY
authors: Demirci
authors: Xingbin
authors: X
authors: Wang
authors: Iltaf
authors: I
authors: Ahmed
authors: Mushtaq
authors: M
authors: Ahmed
authors: M Michael
authors: MM
authors: Barmada
authors: Javaid M
authors: JM
authors: Malik
authors: Peter
authors: P
authors: John
authors: M Ilyas
authors: MI
authors: Kamboh
mesh_terms: D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics