title: Effects of exogenous interleukin-7 on CD8(+) T-cell survival and function in human T-cell lymphotropic virus type 1 infection.
abstract: Interleukin-7 (IL-7) mediates T-cell homeostasis through its effects on T-cell development, survival and function. In human T-cell lymphotropic virus type 1 (HTLV-1) infection, which is causally implicated in adult T-cell leukemia (ATL), the efficiency with which CD8(+) cytotoxic T-lymphocytes (CTLs) clear HTLV-1-infected cells mediates viral control and may be related to disease progression. We report here that CD127 expression in CD8(+) T-cells is independently related to disease status, and that exogenous IL-7 enhances CD8(+) T-cell survival and clearance of HTLV-1 infected cells in vitro. We conclude that CD127 down-regulation may be associated with disease status in HTLV-1 infection, and propose that exogenous IL-7 may be useful immunotherapy or cytokine adjuvant for an anti-ATL therapeutic vaccine.
authors: Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan.
authors: Yohann
authors: Y
authors: White
authors: Makoto
authors: M
authors: Yoshimitsu
authors: Tomohiro
authors: T
authors: Kozako
authors: Kakushi
authors: K
authors: Matsushita
authors: Chihaya
authors: C
authors: Koriyama
authors: Kimiharu
authors: K
authors: Uozumi
authors: Shinsuke
authors: S
authors: Suzuki
authors: Hiroki
authors: H
authors: Kofune
authors: Naomichi
authors: N
authors: Arima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000276:immunology*; D006801:Humans; D015851:Interleukin-7 / Q000494:pharmacology*; D053699:Interleukin-7 Receptor alpha Subunit / Q000378:metabolism; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D015851:Interleukin-7; D053699:Interleukin-7 Receptor alpha Subunit