title: Label-free chemiresistive biosensor for mercury (II) based on single-walled carbon nanotubes and structure-switching DNA.
abstract: Herein, we present a sensitive, selective, and facile label-free DNA functionalized single-walled carbon nanotube (SWNT)-based chemiresistive biosensor for the detection of Hg(2+). SWNTs were functionalized with Hg(2+) binding 15-bases long polyT oligonucleotide through covalent attachment using a bilinker molecule. The polyT was further hybridized with polyA to form a polyT-polyA duplex. When exposed to Hg(2+) the polyT-polyA duplex was dehybridized combined with switching of polyT structure, leading to change in resistance/conductance of the SWNT chemiresistor device. The device provided a significant response within 100 to 1000 nM of Hg(2+) concentration with a 6.72 × 10(-3) nM(-1) sensitivity.
authors: Department of Chemical and Environmental Engineering, University of California, Riverside, California 92521, USA ; College of Environmental Science and Engineering, Hunan University, Changsha 410082, China.
authors: Ji-Lai
authors: JL
authors: Gong
authors: Tapan
authors: T
authors: Sarkar
authors: Sushmee
authors: S
authors: Badhulika
authors: Ashok
authors: A
authors: Mulchandani
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