title: T helper 17 cells in airway diseases: from laboratory bench to bedside.
abstract: T helper 17 (Th17) cytokines are now widely believed to be critical for the regulation of various chronic immune diseases. Investigations have revealed a significant role for IL-17 cytokines in regulating inflammation and modulating lung and airway structural cells in asthma and COPD. In this review, our current understanding of the role of Th17-associated cytokines in airway diseases is summarized. Therapeutic approaches targeting IL-17 during asthma and COPD are also discussed.
authors: Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors: Rabih
authors: R
authors: Halwani
authors: Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors: Saleh
authors: S
authors: Al-Muhsen
authors: Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia; Meakins-Christie Laboratories, Faculty of Medicine, McGill University, Montreal, QC, Canada. Electronic address: qutayba.hamid@mcgill.ca.
authors: Qutayba
authors: Q
authors: Hamid
mesh_terms: D001249:Asthma / Q000503:physiopathology; D006801:Humans; D020381:Interleukin-17 / Q000502:physiology; D008171:Lung Diseases / Q000503:physiopathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology; D058504:Th17 Cells / Q000502:physiology*; D057170:Translational Research, Biomedical
chemical_list: D020381:Interleukin-17