title: Clinical outcome of pelvic exenteration in patients with advanced or recurrent uterine cervical cancer.
abstract: BACKGROUND
  Pelvic exenteration has attained an important role in the treatment of advanced or recurrent cervical cancer for obtaining a complete cure or longer disease-free survival. The purpose of this study was to evaluate patients undergoing pelvic exenteration and to determine the clinical features associated with outcome and survival.
  
  
  METHODS
  We retrospectively analyzed the records of 12 patients who underwent pelvic exenteration for uterine cervical cancer between July 2002 and August 2011.
  
  
  RESULTS
  Two patients had primary stage IVA cervical adenocarcinoma and 10 patients had recurrent cervical cancer. Eight patients underwent anterior pelvic exenteration, 3 patients underwent total pelvic exenteration, and 1 patient underwent posterior pelvic exenteration. With a median duration of follow-up of 22 months (range 3-116 months), 5 patients were alive without recurrence. Of 5 patients with no evidence of disease, 4 were recurrent or residual tumor, all of whom had common factors, such as a tumor size ≤ 30 mm, negative surgical margins, complete resection, and no lymph node involvement. The 5-year overall survival rate for 12 patients was 42.2 %. Ileus was the most common complication (42 %) and post-operative intestinal anastomosis leaks developed in 3 patients, but no ureteral anastomosis leaks occurred.
  
  
  CONCLUSIONS
  Pelvic exenteration is a feasible surgical procedure in advanced and/or recurrent cervical cancer patients with no associated post-operative mortality, and the only therapeutic option for complete cure or long-term survival; however, post-operative complications frequently occur.
authors: Department of Obstetrics and Gynecology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
authors: Sota
authors: S
authors: Tanaka
authors: Satoru
authors: S
authors: Nagase
authors: Michiko
authors: M
authors: Kaiho-Sakuma
authors: Tomoyuki
authors: T
authors: Nagai
authors: Hiroki
authors: H
authors: Kurosawa
authors: Masafumi
authors: M
authors: Toyoshima
authors: Hideki
authors: H
authors: Tokunaga
authors: Takeo
authors: T
authors: Otsuki
authors: Hiroki
authors: H
authors: Utsunomiya
authors: Tadao
authors: T
authors: Takano
authors: Hitoshi
authors: H
authors: Niikura
authors: Kiyoshi
authors: K
authors: Ito
authors: Nobuo
authors: N
authors: Yaegashi
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D010385:Pelvic Exenteration; D011183:Postoperative Complications / Q000473:pathology; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*
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