title: Interim estimates of influenza vaccine effectiveness in 2012/13 from Canada's sentinel surveillance network, January 2013.
abstract: The 2012/13 influenza season in Canada has been characterised to date by early and moderately severe activity, dominated (90%) by the A(H3N2) subtype. Vaccine effectiveness (VE) was assessed in January 2013 by Canada's sentinel surveillance network using a test-negative case-control design. Interim adjusted-VE against medically attended laboratory-confirmed influenza A(H3N2) infection was 45% (95% CI: 13-66). Influenza A(H3N2) viruses in Canada are similar to the vaccine, based on haemagglutination inhibition; however, antigenic site mutations are described in the haemagglutinin gene.
authors: British Columbia Centre for Disease Control, Vancouver, Canada. danuta.skowronski@bccdc.ca
authors: D M
authors: DM
authors: Skowronski
authors: N Z
authors: NZ
authors: Janjua
authors: G
authors: G
authors: De Serres
authors: J A
authors: JA
authors: Dickinson
authors: A-L
authors: AL
authors: Winter
authors: S M
authors: SM
authors: Mahmud
authors: S
authors: S
authors: Sabaiduc
authors: J B
authors: JB
authors: Gubbay
authors: H
authors: H
authors: Charest
authors: M
authors: M
authors: Petric
authors: K
authors: K
authors: Fonseca
authors: P
authors: P
authors: Van Caeseele
authors: T L
authors: TL
authors: Kwindt
authors: M
authors: M
authors: Krajden
authors: A
authors: A
authors: Eshaghi
authors: Y
authors: Y
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000956:Antigens, Viral / Q000032:analysis; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009305:Nasopharynx / Q000821:virology; D009666:Nose / Q000821:virology; D010821:Physicians, Family; D016133:Polymerase Chain Reaction; D018571:Sentinel Surveillance; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome
chemical_list: D000956:Antigens, Viral; D007252:Influenza Vaccines