title: Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes.
abstract: It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data including serum sRAGE levels, and prospectively evaluated the association between these parameters and CVD events. The median follow-up period was 5.6 years and there were 25 new CVD events. The tertile analysis showed that the risk for CVD events was higher as serum sRAGE levels were increased (p for trend = 0.046). A multivariate Cox proportional hazards regression analysis revealed that serum sRAGE levels were independently associated with CVD (HR per 1SD = 1.59, 95% CI 1.04-2.45, p = 0.034), even after adjusting for conventional coronary risk factors. In summary, elevated sRAGE levels were associated with the increased risk of CVD in Japanese type 2 diabetic subjects.
authors: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Keiko
authors: K
authors: Fujisawa
authors: Naoto
authors: N
authors: Katakami
authors: Hideaki
authors: H
authors: Kaneto
authors: Toyoko
authors: T
authors: Naka
authors: Mitsuyoshi
authors: M
authors: Takahara
authors: Fumie
authors: F
authors: Sakamoto
authors: Yoko
authors: Y
authors: Irie
authors: Kazuyuki
authors: K
authors: Miyashita
authors: Fumiyo
authors: F
authors: Kubo
authors: Tetsuyuki
authors: T
authors: Yasuda
authors: Taka-Aki
authors: TA
authors: Matsuoka
authors: Iichiro
authors: I
authors: Shimomura
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000150:complications; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications; D048909:Diabetes Complications / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D012044:Regression Analysis; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic