title: Clinical experience in invasive fungal infections.
abstract: Lung infections caused by invasive filamentous fungi are very rare conditions in AIDS, but must be considered in patients with profound immune suppression especially in the presence of additional risk factors, such as hematologic malignancies, corticosteroid therapy, neutropenia, and chemotherapy. The authors report a case of dual lung infection caused by Aspergillus and Mucor, which occurred in a 34-year-old AIDS patient who was treated with chemotherapy for oral plasmablastic lymphoma. The case presented clinically with low grade fever and pulmonary cavitation, which suggested tuberculosis. After extensive investigation the diagnosis of mucormycosis was established and the patient was treated sequentially with liposomal amphotericin B and posaconazole. Despite a reduction in the size of the pulmonary cavitation, improvement of the lung interstitial infiltrates and clinical recovery, the patient was submitted to cardiothoracic surgery given the aggressive behavior of this invasive fungus. Histology of the surgical specimen showed numerous hyphae with a morphologic pattern compatible with Aspergillus as well as hyphae that were suggestive of Mucor.
authors: Infectious Diseases Department, Hospital Prof. Dr. Fernando Fonseca, Amadora-Sintra, Portugal. patriciacorreiapacheco@gmail.com
authors: Patrícia
authors: P
authors: Pacheco
authors: Ana Sofia
authors: AS
authors: Ventura
authors: Teresa
authors: T
authors: Branco
authors: Lucília
authors: L
authors: Gonçalves
authors: Célia
authors: C
authors: Carvalho
mesh_terms: D000328:Adult; D001230:Aspergillus; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000601:surgery / Q000821:virology; D006801:Humans; D009089:Mucor; D009091:Mucormycosis / Q000175:diagnosis* / Q000382:microbiology / Q000601:surgery; D055732:Pulmonary Aspergillosis / Q000175:diagnosis* / Q000382:microbiology / Q000601:surgery
references: Clin Microbiol Infect. 2009 Oct;15 Suppl 5:77-81
references: 19754763
references: J Clin Microbiol. 2009 Jun;47(6):1650-6
references: 19386856
references: Clin Microbiol Infect. 2009 Oct;15 Suppl 5:71-6
references: 19754762
references: Ann Thorac Surg. 1994 Apr;57(4):1044-50
references: 8166512
references: Clin Microbiol Infect. 2009 Oct;15 Suppl 5:66-70
references: 19754761
references: Chest. 1983 Mar;83(3):585
references: 6825501
references: Infect Dis Clin North Am. 1989 Mar;3(1):19-41
references: 2647832
references: Infect Dis Clin North Am. 2002 Dec;16(4):895-914, vi
references: 12512186
references: Clin Microbiol Infect. 2009 Oct;15 Suppl 5:60-5
references: 19754760