title: Effect of decreased implant healing time on bone (re)modeling adjacent to plateaued implants under functional loading in a dog model.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effect of early functional loading to plateaued implants on bone formation and implant stability in a dog model.
  
  
  METHODS
  Early loading (EL), nonloading control, and delayed loading (DL) groups were compared using six beagle dogs under functional loading. The Periotest® values were measured dynamically for 6 weeks. Peri-implant bone architecture was evaluated qualitatively by microcomputed tomography (μCT) and analyzed quantitatively by mineral apposition rates (MAR), bone-to-implant contact (BIC), and bone volumes (BV/TV) after the euthanasia at 3 and 6 weeks after loading.
  
  
  RESULTS
  The EL implants showed poor stability at 1 week, but greater stability at 2 and 4 weeks after loading compared to DL implants. There was no significant difference between MAR of EL and unloaded implants at both time intervals. The EL implants displayed a significantly higher MAR when compared to DL implants at 3-5 weeks. A significantly higher BIC for the DL group was observed when compared to the EL group at 3 weeks following loading, however at 6 weeks; no significant difference between these groups was observed. The EL group gained a higher BIC than the no-treatment control group at 6 weeks.
  
  
  CONCLUSIONS
  For plateaued implant, the decreased healing time (1 week) displays a positive effect on peri-implant bone (re)modeling under functional loading during the early phase.
  
  
  CONCLUSIONS
  The early application of functional loading on plateaued implants can be used clinically to shorten the course of treatment and improve esthetics.
authors: Ministry Education Key Laboratory for Oral Biomedical Engineering, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People's Republic of China.
authors: Jing
authors: J
authors: Dai
authors: Ning
authors: N
authors: Cheng
authors: Richard J
authors: RJ
authors: Miron
authors: Bin
authors: B
authors: Shi
authors: Xiangrong
authors: X
authors: Cheng
authors: Yufeng
authors: Y
authors: Zhang
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D004285:Dogs; D005260:Female; D057893:Immediate Dental Implant Loading / Q000379:methods*; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D023421:Models, Animal; D014945:Wound Healing; D055114:X-Ray Microtomography
references: Biomacromolecules. 2010 May 10;11(5):1254-60
references: 20361762
references: Eur J Oral Sci. 2007 Feb;115(1):21-9
references: 17305713
references: Clin Implant Dent Relat Res. 2010 Sep;12(3):202-8
references: 19438947
references: Quintessenz. 1991 Aug;42(8):1255-63
references: 1817274
references: Int J Prosthodont. 2004 Sep-Oct;17(5):544-64
references: 15543911
references: Int J Prosthodont. 2004 Sep-Oct;17(5):536-43
references: 15543910
references: Int J Oral Maxillofac Implants. 1991 Spring;6(1):55-61
references: 1843494
references: Clin Oral Implants Res. 2003 Jun;14(3):312-21
references: 12755781
references: Clin Oral Implants Res. 2008 Aug;19(8):733-9
references: 18492084
references: Tissue Eng Part B Rev. 2010 Apr;16(2):209-17
references: 19857045
references: J Prosthet Dent. 2005 Sep;94(3):242-58
references: 16126077
references: Int J Oral Maxillofac Implants. 1990 Winter;5(4):390-400
references: 2094658
references: J Oral Implantol. 2004;30(5):318-24
references: 15587023
references: Int J Periodontics Restorative Dent. 1997 Apr;17(2):162-9
references: 9497710
references: Clin Oral Implants Res. 2003 Jun;14(3):251-62
references: 12755774
references: Int J Periodontics Restorative Dent. 1999 Aug;19(4):343-53
references: 10709501
references: J Dent Res. 2004 Jul;83(7):529-33
references: 15218041
references: Clin Oral Implants Res. 2009 Mar;20(3):232-9
references: 19397634
references: Biomaterials. 2002 Apr;23(8):1809-17
references: 11950051
references: J Biomed Mater Res B Appl Biomater. 2009 Feb;88(2):387-93
references: 18395823
references: Int J Oral Maxillofac Surg. 2010 Jul;39(7):690-8
references: 20418064
references: J Clin Periodontol. 2007 Jul;34(7):618-24
references: 17555413
references: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Apr;107(4):513-8
references: 19095473
references: Clin Oral Implants Res. 2005 Aug;16(4):402-7
references: 16117763
references: Int J Oral Maxillofac Implants. 2004;19 Suppl:109-13
references: 15635951
references: Acta Orthop Scand. 1981;52(2):155-70
references: 7246093
references: Eur J Oral Sci. 2006 Jun;114(3):232-42
references: 16776773
references: Biomaterials. 2008 Feb;29(4):461-74
references: 17983650
references: Clin Implant Dent Relat Res. 2005;7(2):95-104
references: 15996356
references: J Dent Educ. 1988 Dec;52(12):804-9
references: 3057027
references: Clin Oral Implants Res. 2011 Mar;22(3):330-7
references: 20868456
references: Clin Implant Dent Relat Res. 2009 Dec;11(4):338-47
references: 19438966
references: Int J Oral Maxillofac Implants. 2003 Sep-Oct;18(5):729-38
references: 14579962
references: Clin Implant Dent Relat Res. 2004;6(2):90-100
references: 15669709
references: Comput Methods Biomech Biomed Engin. 2009 Aug;12(4):459-68
references: 19199168
references: J Dent Res. 2003 Aug;82(8):585-91
references: 12885840
references: Clin Oral Implants Res. 1995 Mar;6(1):31-9
references: 7669865
references: J Clin Periodontol. 2007 Apr;34(4):359-66
references: 17378890