title: Ilex paraguariensis (yerba mate) improves endocrine and metabolic disorders in obese rats primed by early weaning.
abstract: OBJECTIVE
  We showed that early weaned rats developed obesity, hyperleptinemia, leptin and insulin resistance at adulthood. Here, we studied the potential beneficial effects of Ilex paraguariensis aqueous solution upon body composition, glycemia, lipid and hormonal profiles, leptin signaling and NPY content.
  
  
  METHODS
  To induce early weaning, lactating rats' teats were blocked with a bandage to interrupt lactation during the last 3 days (EW group), while control offspring had free access to milk throughout lactation (C group). In postnatal day (PN) 150, EW offspring were subdivided into: EW and EW+ mate groups treated, respectively, with water or yerba mate aqueous solution (1 g/kg BW/day, gavage) during 30 days. C offspring received water for gavage. In PN180, offspring were killed.
  
  
  RESULTS
  EW+ mate group presented lower body weight (-10 %), adipose mass (retroperitoneal:-40 % and epididymal:-44 %), total body fat (-43 %), subcutaneous fat (-46 %), visceral adipocyte area (-21 %), triglyceridemia (-31 %) and hypothalamic NPY content (-37 %) compared to EW group. However, hyperglycemia and lower HDL-c levels observed in EW group were not reverted with mate treatment. Although the hyperleptinemia, lower hypothalamic JAK2 and pSTAT3 content of EW group were not corrected by mate treatment, the hyperphagia and higher hypothalamic SOCS-3 content were normalized in EW+ mate group, indicating that the central leptin resistance could be restored.
  
  
  CONCLUSIONS
  Thus, the therapy with yerba mate solution was capable to reverse abdominal obesity, leptin resistance and hypertriglyceridemia, suggesting an important role of this bioactive component in the management of obesity in this programming model.
authors: Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, 20551-030, Brazil.
authors: Natália da S
authors: Nda S
authors: Lima
authors: Juliana G
authors: JG
authors: Franco
authors: Nayara
authors: N
authors: Peixoto-Silva
authors: Lígia A
authors: LA
authors: Maia
authors: Andrea
authors: A
authors: Kaezer
authors: Israel
authors: I
authors: Felzenszwalb
authors: Elaine
authors: E
authors: de Oliveira
authors: Egberto G
authors: EG
authors: de Moura
authors: Patricia Cristina
authors: PC
authors: Lisboa
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy; D005260:Female; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D030019:Ilex paraguariensis / Q000737:chemistry*; D007333:Insulin Resistance; D053614:Janus Kinase 2 / Q000378:metabolism; D007774:Lactation; D020738:Leptin / Q000097:blood / Q000502:physiology*; D009478:Neuropeptide Y / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D050796:STAT3 Transcription Factor / Q000378:metabolism; D050151:Subcutaneous Fat / Q000187:drug effects / Q000378:metabolism; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism; D014886:Weaning
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D020738:Leptin; D009478:Neuropeptide Y; D010936:Plant Extracts; D050796:STAT3 Transcription Factor; C491410:Socs3 protein, rat; C494088:Stat3 protein, rat; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; C507927:Jak2 protein, rat; D053614:Janus Kinase 2
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