title: A high intake of dietary fiber influences C-reactive protein and fibrinogen, but not glucose and lipid metabolism, in mildly hypercholesterolemic subjects.
abstract: OBJECTIVE
  The aim of the study was to investigate how a diet high in dietary fiber, with several fiber sources included, modulates glucose and lipid metabolism and the inflammatory response in humans.
  
  
  METHODS
  Subjects (n = 25) aged 58.6 (1.1) years (mean and SD) with a BMI of 26.6 (0.5) kg/m(2) and a total cholesterol (TC) of 5.8 (0.1) mmol/L (mean and SEM) were given a high fiber (HF) and low fiber (LF) diet, in a randomized controlled 5-week crossover intervention, separated by a 3-week washout. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products; one bread roll, one ready meal, and two beverages consumed daily. Equivalent food products, without added fibers, were provided in the LF diet.
  
  
  RESULTS
  Total dietary fiber intake was 48.0 g and 30.2 g per day for the HF and LF diet, respectively. Significant reduction in C-reactive protein (CRP) was observed between the diets (P = 0.017) and a significant reduction in fibrinogen within the HF diet (P = 0.044). There were no significant effects in other measured circulating cytokines or in glucose, insulin, and lipid levels.
  
  
  CONCLUSIONS
  Our study suggests that a 5-week high dietary fiber intake of oat bran, rye bran, and sugar beet fiber might reduce the low-grade inflammatory response measured as CRP which could, together with reduced fibrinogen, help to prevent the risk of cardiovascular disease.
authors: Biomedical Nutrition, Pure and Applied Biochemistry, Center for Applied Life Sciences, Lund University, P.O. Box 124, SE-22100, Lund, Sweden.
authors: Anna
authors: A
authors: Johansson-Persson
authors: Matilda
authors: M
authors: Ulmius
authors: Lieselotte
authors: L
authors: Cloetens
authors: Toni
authors: T
authors: Karhu
authors: Karl-Heinz
authors: KH
authors: Herzig
authors: Gunilla
authors: G
authors: Onning
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D018592:Cross-Over Studies; D004043:Dietary Fiber / Q000008:administration & dosage*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D064368:Healthy Volunteers; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy*; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D005340:Fibrinogen; D002097:C-Reactive Protein
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