title: Evaluation of IL-2-withdrawal-induced apoptosis in human T lymphocytes.
abstract: Proper lymphocyte apoptosis is critical for the maintenance of immune system homeostasis, and evaluation of cell death is useful in a number of clinical and research settings. We describe here how to evaluate the integrity of the intrinsic pathway of lymphocyte apoptosis triggered by starvation for IL-2 or other survival cytokines.
authors: Pediatrics Department, Medical Institute Prof. Fernando Figueira-IMIP, Recife, PE, Brazil. oliveirajb@cc.nih.gov
authors: Joao Bosco
authors: JB
authors: Oliveira
mesh_terms: D017209:Apoptosis / Q000276:immunology*; D001681:Biological Assay; D018929:Cell Culture Techniques; D006801:Humans; D007376:Interleukin-2 / Q000172:deficiency*; D008213:Lymphocyte Activation; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*
chemical_list: D007376:Interleukin-2