title: On the reliability of quantitation of biological effect in drug-interceptor-DNA systems.
abstract: Relative insensitivity of theoretical estimation of biological effect in drug-interceptor-DNA systems is found with respect to variation of parameters of quasiphysiological conditions. The "inertness" of the biological response, in part, justifies the use of parameters of intermolecular interaction, derived from independent physicochemical experiments, in estimation of relative biological effect in the theory of interceptor/protector action.
authors: Department of Physics, Sevastopol National Technical University, 33 Universitetskaya Str., Sevastopol 99053, Ukraine. tolybas@rambler.ru
authors: Anatoly S
authors: AS
authors: Buchelnikov
authors: Vladyslav P
authors: VP
authors: Evstigneev
authors: Leticia E
authors: LE
authors: Rodríguez Oropeza
authors: Maxim P
authors: MP
authors: Evstigneev
mesh_terms: D001667:Binding, Competitive; D004247:DNA / Q000378:metabolism*; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D015203:Reproducibility of Results
chemical_list: D004364:Pharmaceutical Preparations; D004247:DNA
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