title: Negative regulation of TBK1-mediated antiviral immunity.
abstract: TANK-binding kinase 1 (TBK1) plays pivotal roles in antiviral innate immunity. TBK1 mediates the activation of interferon regulatory factor (IRF) 3, leading to the induction of type I IFNs (IFN-α/β) following viral infections. TBK1 must be tightly regulated to effectively control viral infections and maintain immune homeostasis. TBK1 activity can be regulated in a variety of ways, such as phosphorylation, ubiquitination, kinase activity modulation and prevention of functional TBK1-containing complexes formation. Furthermore, multiple viruses have evolved elaborate strategies to circumvent IFN responses by targeting TBK1. Here we provide an overview of TBK1 in antiviral immunity and recent developments on the regulation of TBK1 activity.
authors: Department of Immunology, Shandong University School of Medicine, Jinan, Shandong 250012, China. wzhao@sdu.edu.cn
authors: Wei
authors: W
authors: Zhao
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology*; D006706:Homeostasis / Q000235:genetics / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate / Q000235:genetics; D050838:Interferon Regulatory Factor-3 / Q000235:genetics* / Q000276:immunology; D007370:Interferon Type I / Q000235:genetics* / Q000276:immunology; D051379:Mice; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000821:virology; D014780:Viruses / Q000276:immunology*
chemical_list: C494232:IRF3 protein, human; D050838:Interferon Regulatory Factor-3; D007370:Interferon Type I; D017346:Protein Serine-Threonine Kinases; C403191:TBK1 protein, human
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