title: Hematopoietic progenitors express myelin basic protein and ensheath axons in Shiverer brain.
abstract: Oligodendroglia are cells of the central nervous system (CNS) that form myelin sheath, which insulates neuronal axons. Neuropathologies of the CNS include dysmyelination of axons in multiple sclerosis and CNS trauma. Cell replacement is a promising but largely untested therapy for dysmyelination. Shiverer mouse, a genetic mutant that does not synthesize full-length myelin basic protein (MBP), a critical prerequisite protein in CNS myelin sheath formation, provides an unequivocal model for determining the potential of stem cells to become oligodendroglia. We demonstrate that adult wild-type mouse bone marrow stem cells can express MBP and ensheath axons when transplanted into Shiverer brain.
authors: Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. JGoolsby@paragonbioservices.com
authors: James
authors: J
authors: Goolsby
authors: Tapas
authors: T
authors: Makar
authors: Suhayl
authors: S
authors: Dhib-Jalbut
authors: Christopher T
authors: CT
authors: Bever
authors: Bernard
authors: B
authors: Pessac
authors: David
authors: D
authors: Trisler
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002478:Cells, Cultured; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D008818:Mice, Neurologic Mutants; D004676:Myelin Basic Protein / Q000096:biosynthesis*; D009186:Myelin Sheath / Q000378:metabolism* / Q000473:pathology
chemical_list: D004676:Myelin Basic Protein