title: Seroepidemiology of varicella-zoster virus in Korea.
abstract: This study was designed to assess the immune status of the Korean population against varicella-zoster virus (VZV) through a seroepidemiologic study. Residual blood samples were collected from diagnostic laboratories throughout Korea. Samples were collected in October 2009 to March 2010 from persons 0-79 yr of age and were tested by ELISA (Enzygnost®; Dade Behring, Schwalbach, Germany). Total seroprevalence in subjects 1-79 yr of age was 89.6%. Seroprevalence increased as age increased from 67.3% in subjects 1-4 yr of age to 94.2% in subjects 10-14 yr of age and in subjects over 20 yr of age seroprevalence ranged from 98.0% to 100%. In children under 1 yr of age, passive immunity waned after birth with none of the subjects having antibodies from 7 months of age and over. Among subjects 1-79 yr of age, susceptible subjects to VZV were mainly under 20 yr of age. These results provide information in understanding the dynamics of varicella disease in Korea, which is important in building up strategies for disease control.
authors: Department of Pediatrics, Ewha Womans University, Seoul, Korea.
authors: Hyunju
authors: H
authors: Lee
authors: Hye Kyung
authors: HK
authors: Cho
authors: Kyung-Hyo
authors: KH
authors: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D002644:Chickenpox / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006562:Herpes Zoster / Q000453:epidemiology*; D014645:Herpesvirus 3, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral
keywords: Korean; Seroepidemiology; Seroprevalence; Varicella-Zoster Virus
references: N Engl J Med. 2007 Mar 15;356(11):1121-9
references: 17360990
references: MMWR Recomm Rep. 2007 Jun 22;56(RR-4):1-40
references: 17585291
references: J Clin Virol. 2006 Jun;36(2):111-8
references: 16616612
references: J Med Virol. 2003;70 Suppl 1:S111-8
references: 12627498
references: J Infect Dis. 2008 Apr 1;197(7):944-9
references: 18419532
references: J Infect Dis. 1995 Sep;172(3):706-12
references: 7658062
references: MMWR Morb Mortal Wkly Rep. 2004 May 14;53(18):389-92
references: 15138400
references: J Med Virol. 2010 Dec;82(12):2123-6
references: 20981803
references: BMC Public Health. 2008 Oct 27;8:372
references: 18954432
references: Lancet. 1974 Nov 30;2(7892):1288-90
references: 4139526
references: Lancet. 1952 Sep 20;2(6734):549-54
references: 12981903
references: Epidemiol Infect. 2003 Dec;131(3):1085-9
references: 14959774
references: J Korean Med Sci. 2011 Jun;26(6):711-9
references: 21655054
references: Ann Dermatol. 2011 Feb;23(1):39-43
references: 21738361
references: Wkly Epidemiol Rec. 1998 Aug 7;73(32):241-8
references: 9715106
references: J Clin Microbiol. 2006 Sep;44(9):3094-7
references: 16954232
references: Pediatrics. 2006 Jun;117(6):e1070-7
references: 16740809