title: Psoriasis, a new challenge for laboratory medicine.
abstract: Psoriasis is an immune-mediated, chronic, inflammatory disease that affects the skin and joints. Because of its high incidence and of its clinical symptoms it has a very strong social impact. In a genetically predisposed individual, the maintenance of the skin barrier integrity is strongly compromised in response to either environmental or self-antigenic insults. A persistent dysregulation of the skin immune system causes the typical evolutive skin lesions of psoriasis and recurrence of the disease. The most efficient laboratory approach consists of a well-defined evaluation of immune response in order to help diagnosis, to monitor evolution, and to evaluate the effects of individualized therapeutic treatments.
authors: Clinical Pathology Unit, Department of Health Sciences, University Magna Graecia, Catanzaro, Italy. gulletta@unicz.it
authors: Elio
authors: E
authors: Gulletta
authors: Ugo
authors: U
authors: Bottoni
authors: Daniela P
authors: DP
authors: Foti
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis; D018450:Disease Progression; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D015236:HLA-C Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D020381:Interleukin-17 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D053759:Interleukin-23 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D016133:Polymerase Chain Reaction; D040081:Protein Array Analysis; D011565:Psoriasis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D012867:Skin / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D015236:HLA-C Antigens; C491620:HLA-C*06:02 antigen; D020381:Interleukin-17; D053759:Interleukin-23