title: Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study--TROFI trial.
abstract: OBJECTIVE
  Primary percutaneous coronary intervention (PPCI) with thrombectomy (TB) seems to reduce the thrombus burden, resulting in a larger flow area as measured with optical frequency domain imaging (OFDI).
  
  
  RESULTS
  In a multi-centre study, 141 patients with ST elevation myocardial infarction <12 h from onset were randomized to either PPCI with TB using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70), having operators blinded for the OFDI results. The primary endpoint was minimum flow area (MinFA) post-procedure assessed by OFDI, defined as: [stent area + incomplete stent apposition (ISA) area] - (intraluminal defect + tissue prolapse area). Sample size was based on the expected difference of 0.72 mm(2) in MinFA. Baseline demographics, pre-procedural quantitative coronary angiography (QCA), and procedural characteristics were well matched between the two groups. On OFDI, the stent area (TB: 7.62 ± 2.23 mm(2), non-TB: 7.05 ± 2.12 mm(2), P = 0.14) and MinFA (TB: 7.08 ± 2.14 mm(2) vs. non-TB: 6.51 ± 1.99 mm(2), Δ0.57 mm(2), P = 0.12) were not different. In addition, the amount of protrusion, intraluminal defect, and ISA area were similar in the both groups.
  
  
  CONCLUSIONS
  PPCI with TB was associated with a similar flow area as well as stent area to PPCI without TB.
authors: Thorax Center Ba-583, Erasmus Medical Center, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors: Yoshinobu
authors: Y
authors: Onuma
authors: Leif
authors: L
authors: Thuesen
authors: Robert-Jan
authors: RJ
authors: van Geuns
authors: Martin
authors: M
authors: van der Ent
authors: Steffen
authors: S
authors: Desch
authors: Jean
authors: J
authors: Fajadet
authors: Evald
authors: E
authors: Christiansen
authors: Peter
authors: P
authors: Smits
authors: Niels Ramsing
authors: NR
authors: Holm
authors: Evelyn
authors: E
authors: Regar
authors: Nicolas
authors: N
authors: van Mieghem
authors: Vladimir
authors: V
authors: Borovicanin
authors: Dragica
authors: D
authors: Paunovic
authors: Kazuhisa
authors: K
authors: Senshu
authors: Gerrit-Anne
authors: GA
authors: van Es
authors: Takashi
authors: T
authors: Muramatsu
authors: Il-Soo
authors: IS
authors: Lee
authors: Gerhard
authors: G
authors: Schuler
authors: Felix
authors: F
authors: Zijlstra
authors: Hector M
authors: HM
authors: Garcia-Garcia
authors: Patrick W
authors: PW
authors: Serruys
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D057791:Cardiac Imaging Techniques / Q000379:methods; D003326:Coronary Circulation / Q000502:physiology; D003328:Coronary Thrombosis / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011446:Prospective Studies; D017131:Thrombectomy / Q000379:methods*; D016896:Treatment Outcome