title: Differential contribution of hippocampal circuits to appetitive and consummatory behaviors during operant conditioning of behaving mice.
abstract: Operant conditioning is a type of associative learning involving different and complex sensorimotor and cognitive processes. Because the hippocampus has been related to some motor and cognitive functions involved in this type of learning (such as object recognition, spatial orientation, and associative learning tasks), we decided to study in behaving mice the putative changes in strength taking place at the hippocampal CA3-CA1 synapses during the acquisition and performance of an operant conditioning task. Mice were chronically implanted with stimulating electrodes in the Schaffer collaterals and with recording electrodes in the hippocampal CA1 area and trained to an operant task using a fixed-ratio (1:1) schedule. We recorded the field EPSPs (fEPSPs) evoked at the CA3-CA1 synapse during the performance of appetitive (going to the lever, lever press) and consummatory (going to the feeder, eating) behaviors. In addition, we recorded the local field potential activity of the CA1 area during similar behavioral displays. fEPSPs evoked at the CA3-CA1 synapse presented larger amplitudes for appetitive than for consummatory behaviors. This differential change in synaptic strength took place in relation to the learning process, depending mainly on the moment in which mice reached the selected criterion. Thus, selective changes in CA3-CA1 synaptic strength were dependent on both the behavior display and the learning stage. In addition, significant changes in theta band power peaks and their corresponding discrete frequencies were noticed during these behaviors across the sequence of events characterizing this type of associative learning but not during the acquisition process.
authors: Division of Neurosciences, Pablo de Olavide University, 41013 Seville, Spain.
authors: M Teresa
authors: MT
authors: Jurado-Parras
authors: Raudel
authors: R
authors: Sánchez-Campusano
authors: Nazareth P
authors: NP
authors: Castellanos
authors: Francisco
authors: F
authors: del-Pozo
authors: Agnès
authors: A
authors: Gruart
authors: José M
authors: JM
authors: Delgado-García
mesh_terms: D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology*; D003216:Conditioning, Operant / Q000502:physiology*; D003259:Consummatory Behavior / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology; D009415:Nerve Net / Q000502:physiology*
references: Learn Mem. 2007 January-February;14(1):36-46
references: 17272651
references: Brain Res. 1980 Sep 29;198(1):119-33
references: 7407578
references: Annu Rev Physiol. 2002;64:355-405
references: 11826273
references: Behav Biol. 1973 Apr;8(4):461-84
references: 4350255
references: Science. 2011 Jul 15;333(6040):353-7
references: 21764750
references: Brain Res. 2006 Aug 4;1103(1):159-63
references: 16814756
references: J Comp Neurol. 1973 Jan 15;147(2):145-61
references: 4118866
references: J Neurosci. 2007 Jun 20;27(25):6620-32
references: 17581949
references: Electroencephalogr Clin Neurophysiol. 1978 Sep;45(3):409-11
references: 79479
references: J Neurophysiol. 2008 Feb;99(2):888-99
references: 18046004
references: PLoS One. 2010 Jun 15;5(6):e11130
references: 20559565
references: Science. 1972 Jan 7;175(4017):87-9
references: 5008585
references: PLoS One. 2011 Feb 18;6(2):e14713
references: 21364751
references: Science. 2006 Aug 25;313(5790):1093-7
references: 16931756
references: Neuroscience. 2009 Nov 10;163(4):1031-8
references: 19632308
references: J Neurophysiol. 2010 Jul;104(1):346-65
references: 20410355
references: Neurobiol Learn Mem. 2007 Jan;87(1):9-20
references: 16839788
references: Brain Res. 1980 Sep 29;198(1):95-117
references: 7407597
references: Physiol Behav. 1975 Mar;14(3):391-4
references: 166399
references: Behav Brain Res. 2001 Dec 14;127(1-2):119-36
references: 11718888
references: Physiol Behav. 1972 Aug;9(2):155-9
references: 4654729
references: J Neurosci. 2000 Jun 1;20(11):4233-9
references: 10818159
references: Neuropharmacology. 2007 Jan;52(1):1-11
references: 16919682
references: Brain Res. 1981 Nov 30;225(2):235-47
references: 6272929
references: Nature. 1993 Jan 7;361(6407):31-9
references: 8421494
references: J Neurophysiol. 2012 Jan;107(1):65-77
references: 21975453
references: J Neurosci. 2002 Dec 15;22(24):10976-84
references: 12486193
references: J Neurophysiol. 2001 Nov;86(5):2571-82
references: 11698543
references: J Neurophysiol. 2000 Apr;83(4):2138-44
references: 10758123
references: Hippocampus. 2004;14(5):662-74
references: 15301442
references: Electroencephalogr Clin Neurophysiol. 1969 Apr;26(4):407-18
references: 4183562
references: Exp Neurol. 1976 Apr;51(1):78-109
references: 1261644
references: Neuropsychopharmacology. 2008 Jan;33(1):18-41
references: 17728696
references: Front Behav Neurosci. 2009 May 29;3:7
references: 19636387
references: Prog Neurobiol. 1995 Apr;45(6):523-83
references: 7624485
references: Behav Brain Res. 2008 Jun 26;190(1):152-5
references: 18378012
references: J Physiol. 2003 Jul 15;550(Pt 2):459-92
references: 12794181
references: Annu Rev Neurosci. 2008;31:69-89
references: 18284371
references: Behav Brain Res. 2001 Dec 14;127(1-2):13-23
references: 11718882
references: Nat Rev Neurosci. 2008 Jan;9(1):65-75
references: 18094707
references: Brain Res. 1988 Oct 4;461(2):290-302
references: 2846120
references: Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2652-7
references: 20133798
references: BMC Neurosci. 2005 May 13;6:36
references: 15892889
references: Neuroscience. 2006 Jul 7;140(3):779-90
references: 16581189
references: Neurosci Lett. 1991 Mar 11;124(1):39-43
references: 1677458
references: Neuroscience. 2006 Sep 1;141(3):1123-37
references: 16753261
references: Neurobiol Dis. 2004 Mar;15(2):188-95
references: 15006688
references: J Neurosci. 2006 Jan 25;26(4):1077-87
references: 16436593
references: Learn Mem. 2012 Feb 21;19(3):99-106
references: 22354947
references: Hippocampus. 2005;15(7):936-49
references: 16158423
references: J Neurosci. 2009 Aug 26;29(34):10750-63
references: 19710326
references: Prog Brain Res. 1972;36:41-58
references: 4566255