title: Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease.
abstract: BACKGROUND
  Patients with inflammatory bowel disease (IBD) frequently appear iron deplete but whether this is a reflection of dietary iron intakes is not known.
  
  
  METHODS
  Dietary data were collected from 29 patients with inactive or mildly-active IBD and 28 healthy controls using a validated food frequency questionnaire that measured intakes of iron and its absorption modifiers. Non-haem iron availability was estimated using a recently developed algorithm. Subjects were classified for iron status based upon data from a concomitant and separately published study of iron absorption. Absorption was used to define iron status because haematological parameters are flawed in assessing iron status in inflammatory conditions such as IBD.
  
  
  RESULTS
  Dietary intakes of total iron, non-haem iron and vitamin C were significantly greater in IBD patients who were iron replete compared to those who were iron deplete (by 48%, 48% and 94% respectively; p≤0.05). The predicted percentage of available non-haem iron did not differ between these groups (19.7 ± 2.0% vs 19.3 ± 2.0% respectively; p=0.25). However, because of the difference in iron intake, the overall amount of absorbed iron did (2.4 ± 0.8 mg/d vs 1.7 ± 0.5 mg/d; p=0.013). No such differences were observed in the healthy control subjects.
  
  
  CONCLUSIONS
  In IBD, iron status is more closely related to the quality and quantity of dietary iron intake than in the general healthy population.
authors: MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK. jonathan.powell@mrc-hnr.cam.ac.uk.
authors: Jonathan J
authors: JJ
authors: Powell
authors: William B
authors: WB
authors: Cook
authors: Mark
authors: M
authors: Chatfield
authors: Carol
authors: C
authors: Hutchinson
authors: Dora Ia
authors: DIa
authors: Pereira
authors: Miranda Ce
authors: MC
authors: Lomer
references: Dig Dis Sci. 1994 Sep;39(9):1930-4
references: 8082499
references: Am J Clin Nutr. 1983 Mar;37(3):416-20
references: 6402915
references: Br J Nutr. 2012 Jun;107(12):1806-11
references: 22152498
references: Eur J Clin Nutr. 2000 Jul;54(7):592-9
references: 10918471
references: Am J Clin Nutr. 1995 Apr;61(4):800-4
references: 7702022
references: J Adolesc Health. 2005 Jul;37(1):75
references: 15963912
references: J Nutr. 2006 Jul;136(7):1910-4
references: 16772458
references: Inflamm Bowel Dis. 2007 Dec;13(12):1545-53
references: 17985376
references: Am J Clin Nutr. 2000 May;71(5):1147-60
references: 10799377
references: Br J Nutr. 2009 Dec;102(11):1678-85
references: 19709447
references: Nat Rev Gastroenterol Hepatol. 2010 Nov;7(11):599-610
references: 20924367
references: J Am Coll Nutr. 2008 Feb;27(1):158-67
references: 18460494
references: Gastroenterology. 1989 Mar;96(3):804-10
references: 2644154
references: J Nutr. 2002 Oct;132(10):3146-50
references: 12368409
references: Aliment Pharmacol Ther. 2005 Nov 1;22(9):831-8
references: 16225492
references: Br J Nutr. 1999 Apr;81(4):289-95
references: 10999016
references: Am J Clin Nutr. 1999 Feb;69(2):250-5
references: 9989688
references: Br J Nutr. 2004 Jan;91(1):141-8
references: 14748947
references: World Rev Nutr Diet. 1987;52:235-59
references: 3327233