title: Causal effects of synthetic chemicals on mitochondrial deficits and diabetes pandemic.
abstract: It is generally accepted that mitochondrial deficits cause many common age-associated diseases including type 2 diabetes. However, it has not been understood what causes mitochondrial damages and how to interrupt the development of the diseases in patients. Recent epidemiologic studies demonstrated a positive correlation between serum concentrations of environmental pollutants and insulin resistance/diabetes. Emerging data strongly suggest that some synthetic pollutants disturb the signaling pathway critical for energy homeostasis and insulin action. The synthetic chemicals are possibly involved in pathogenesis of insulin resistance and diabetes as mitochondria-disturbing agents. In this review, we present a molecular scheme to address the contribution of environmental synthetic chemicals to this metabolic catastrophe. Efforts to identify synthetic chemicals with mitochondria-damaging activities may open a new era to develop effective therapeutic interventions against the worldwide-spreading metabolic disorder.
authors: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 130-701, Korea.
authors: Wook-Ha
authors: WH
authors: Park
authors: Young-Chul
authors: YC
authors: Kang
authors: Ying
authors: Y
authors: Piao
authors: Daniel Hyungseok
authors: DH
authors: Pak
authors: Youngmi Kim
authors: YK
authors: Pak
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced* / Q000453:epidemiology* / Q000473:pathology; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D058873:Pandemics; D018336:Receptors, Aryl Hydrocarbon / Q000502:physiology
chemical_list: D004785:Environmental Pollutants; D018336:Receptors, Aryl Hydrocarbon