title: Interaction of somatostatin receptor-2 and neuropeptide Y receptor-1 in mice dorsal root ganglion neurons on the pinch-nerve injury model.
abstract: The aim of this paper was to evaluate the interactions of Somatostatin receptor-2 (SST2) and Neuropeptide Y receptors-1 (Y1) by molecular, pharmacological and behavioral studies. Double-immunolabeling of SST2 and Y1 has shown the colocalization of these two receptors in the dorsal root ganglion (DRG) neurons. On the basis of the Pinch nerve injury model, the mechanical hyperalgesia and severely painful behavior (autotomy) were detected after the application of SST2 antibody (anti-SST2; 200μg/kg) on the pinch-injured nerve. The differential distribution of Y1 and up-regulation of PKC expression in DRGs were observed after anti-SST2 treatment. Our results indicated for the first time the interactions of SST2 and Y1 in DRGs, which have functional role in pain modulation and might give rise to explore possible novel therapeutic strategies against pain.
authors: School of Life Sciences and Technology, Harbin Institute of Technology, Harbin, China. xq_119@163.com
authors: Qiong
authors: Q
authors: Xiang
authors: Chang-Lin
authors: CL
authors: Wang
authors: Shuo
authors: S
authors: Song
authors: Rui
authors: R
authors: Jing
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000737:chemistry; D000818:Animals; D004195:Disease Models, Animal; D015195:Drug Design; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006930:Hyperalgesia / Q000378:metabolism* / Q000523:psychology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D010147:Pain Measurement; D017476:Receptors, Neuropeptide Y / Q000378:metabolism*; D017481:Receptors, Somatostatin / Q000378:metabolism*
chemical_list: D000700:Analgesics; D017476:Receptors, Neuropeptide Y; D017481:Receptors, Somatostatin; C097212:neuropeptide Y-Y1 receptor; C570769:somatostatin receptor 2, mouse