title: Natto (fermented soybean) extract extends the adult lifespan of Caenorhabditis elegans.
abstract: We investigated the effects of a water extract of natto on the aging of the nematode Caenorhabditis elegans. The water extract significantly prolonged the adult lifespan of the wild-type worms and rendered them resistant to oxidative and thermal stress. In addition, treatment with natto extract significantly delayed the accumulation of lipofuscin, a characteristic of aging cells. Our findings suggest that components of natto have a beneficial anti-aging effect in vivo.
authors: Oyamatofu Co., Ltd., Shirone, Isehara, Kanagawa, Japan. sachie_i@tg7.co-net.ne.jp
authors: Sachie
authors: S
authors: Ibe
authors: Kaoru
authors: K
authors: Kumada
authors: Keiko
authors: K
authors: Yoshida
authors: Kazunori
authors: K
authors: Otobe
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000502:physiology; D045424:Complex Mixtures / Q000494:pharmacology*; D005285:Fermentation; D006358:Hot Temperature; D008062:Lipofuscin / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008136:Longevity / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D045730:Soy Foods / Q000032:analysis*; D014867:Water
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D045424:Complex Mixtures; D008062:Lipofuscin; D014867:Water