title: The antibiofilm effects of Byotrol™ G32.
abstract: OBJECTIVE
  The purpose of this study was to evaluate a commercial antimicrobial formulation, Byotrol™ G32, as a potential coating for impeding biofilm formation on medical devices such as urinary catheters.
  
  
  RESULTS
  The antimicrobial activity of Byotrol™ G32 and its individual constituents has been tested on planktonic and biofilm cultures of uropathogenic bacteria. The Byotrol™ G32 formulation was superior with MICs ranging from 3 μg ml(-1) to 15 μg ml(-1) for planktonic cultures and 3-20 μg ml(-1) for biofilms. Furthermore, Byotrol™ G32 was able to remove established biofilms and act as an antibiofilm surface coating.
  
  
  CONCLUSIONS
  Byotrol™ G32 displays impressive antimicrobial activity both in suspension and as a coating. Pretreating medical devices with Byotrol™ G32 may significantly impede biofilm formation and prolong the lifetime of the device.
  
  
  CONCLUSIONS
  Medical devices are indispensable in health care. They are, however, a predisposing factor in infection. This research has demonstrated that Byotrol™ G32 reduces bacterial growth and subsequent biofilm formation. Application of Byotrol™ G32 as a medical device coating could have a significant impact on the costs associated with device replacement and patient morbidity and mortality.
authors: School of Medicine, University of Manchester, Manchester, UK.
authors: N
authors: N
authors: Govindji
authors: P
authors: P
authors: Wills
authors: M
authors: M
authors: Upton
authors: N
authors: N
authors: Tirelli
authors: S
authors: S
authors: Yeates
authors: M
authors: M
authors: Webb
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D001645:Biguanides / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D062885:Urinary Catheters / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents; D001548:Benzalkonium Compounds; D001645:Biguanides; C586341:Byotrol G32; D000644:Quaternary Ammonium Compounds