title: Intensity of the humoral response to cytomegalovirus is associated with the phenotypic and functional status of the immune system.
abstract: Cytomegalovirus (CMV) infection exerts an enormous effect on human immunity, as it is associated with an immune-impaired response, a variety of chronic diseases, and overall survival in elderly individuals. Levels of anti-CMV antibodies may be associated with the differentiation degree of T cell subsets. Titers are significantly higher in the elderly and positively correlated with specific CD4(+) T cell responses to CMV. In the elderly, antibody titers are associated with the degree of differentiation and the T cell receptor excision circle (TREC) content in CD4(+) T cells, with other features of the immune risk profile, and with a reduced ability to respond to immunization in vivo. Associations may be absent in young subjects because their anti-CMV antibody titers are lower than those of the elderly. However, comparing young and elderly individuals with similar antibody levels reveals differences in their highly differentiated and naïve T cells. These are more marked in individuals with high titers. In parallel with the increase in anti-CMV antibodies, the elderly experience a significant reduction in absolute counts of naïve CD4(+) T cells, which may be a strategy to compensate for the expansion of differentiated cells and to avoid an increase in total T cells. In summary, our results show that titers of anti-CMV antibodies, and not only CMV seropositivity, are related to differentiation status and immunocompetence in the elderly, making this as an important prognostic marker of the status of immune system function.
authors: Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors: R
authors: R
authors: Alonso Arias
authors: M A
authors: MA
authors: Moro-García
authors: A
authors: A
authors: Echeverría
authors: J J
authors: JJ
authors: Solano-Jaurrieta
authors: F M
authors: FM
authors: Suárez-García
authors: C
authors: C
authors: López-Larrea
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D002454:Cell Differentiation; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000914:Antibodies, Viral
references: J Am Geriatr Soc. 2006 Jul;54(7):1046-54
references: 16866674
references: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3195-9
references: 9096369
references: J Immunol. 2010 Mar 15;184(6):3242-9
references: 20173031
references: J Immunol. 2002 Jun 1;168(11):5893-9
references: 12023394
references: J Clin Invest. 1995 Apr;95(4):1741-6
references: 7706482
references: Curr Top Microbiol Immunol. 2008;325:297-313
references: 18637513
references: Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4215-20
references: 10737767
references: Exp Gerontol. 2007 Jun;42(6):563-70
references: 17337145
references: Am J Epidemiol. 2010 May 15;171(10):1144-52
references: 20400465
references: JAMA. 2009 Jan 28;301(4):380-2
references: 19176439
references: Exp Gerontol. 2002 Jan-Mar;37(2-3):445-53
references: 11772532
references: Arthritis Rheum. 2005 Oct;52(10):2996-3003
references: 16200579
references: Nat Immunol. 2009 Jan;10(1):29-37
references: 19043418
references: Age (Dordr). 2011 Dec;33(4):607-14
references: 21274637
references: Nature. 1998 Dec 17;396(6712):690-5
references: 9872319
references: Clin Infect Dis. 1998 May;26(5):1076-82
references: 9597229
references: Age (Dordr). 2011 Dec;33(4):591-605
references: 21210234
references: Virology. 2000 Jul 5;272(2):357-65
references: 10873779
references: Lancet. 1993 Feb 20;341(8843):494-5
references: 8094513
references: J Immunol. 2004 Jul 1;173(1):673-81
references: 15210831
references: PLoS One. 2011 Feb 17;6(2):e16103
references: 21379581
references: Nature. 1999 Oct 14;401(6754):708-12
references: 10537110
references: Mech Ageing Dev. 2000 Dec 20;121(1-3):187-201
references: 11164473
references: J Immunol. 2006 Dec 1;177(11):7802-10
references: 17114451
references: Clin Infect Dis. 2006 Nov 1;43(9):1143-51
references: 17029132
references: Nat Rev Immunol. 2008 Jul;8(7):512-22
references: 18469829
references: Age (Dordr). 2012 Apr;34(2):479-95
references: 21487706
references: Aging Cell. 2011 Oct;10(5):844-52
references: 21635686
references: Biogerontology. 2009 Feb;10(1):83-94
references: 18563620
references: J Mol Med (Berl). 2001 Nov;79(11):631-40
references: 11715066
references: J Immunol. 2006 Feb 15;176(4):2645-53
references: 16456027
references: Exp Gerontol. 2007 May;42(5):400-6
references: 17218073
references: Inflamm Res. 2008 Dec;57(12):558-63
references: 19109735
references: J Acquir Immune Defic Syndr. 2009 Aug 1;51(4):390-8
references: 19461524
references: Lancet. 2002 Nov 16;360(9345):1557-63
references: 12443594
references: Clin Immunol. 2008 Apr;127(1):107-18
references: 18222733
references: Int J Epidemiol. 2009 Jun;38(3):775-87
references: 19109247