title: Activation of γ-aminobutyrate production by chloroplastic H(2)O(2) is associated with the oxidative stress response.
abstract: We isolated an Arabidopsis knockout line lacking glutamate decarboxylase 1 (GAD1), one that produced γ-aminobutyrate (GABA), as an oxidative stress-insensitive mutant, and found that chloroplastic H(2)O(2) enhances GAD1 expression and GABA levels. This suggests a possible relationship between GABA metabolism and the chloroplastic H(2)O(2)-mediated stress response.
authors: Department of Advanced Bioscience, Faculty of Agriculture, Kinki University, Nakamachi, Nara, Japan.
authors: Takanori
authors: T
authors: Maruta
authors: Megumi
authors: M
authors: Ojiri
authors: Masahiro
authors: M
authors: Noshi
authors: Masahiro
authors: M
authors: Tamoi
authors: Takahiro
authors: T
authors: Ishikawa
authors: Shigeru
authors: S
authors: Shigeoka
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism; D060387:Ascorbate Peroxidases / Q000172:deficiency / Q000235:genetics; D002736:Chloroplasts / Q000235:genetics* / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D005968:Glutamate Decarboxylase / Q000172:deficiency / Q000235:genetics*; D006861:Hydrogen Peroxide / Q000378:metabolism*; D018384:Oxidative Stress; D030821:Plants, Genetically Modified; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D060431:Thylakoid Membrane Proteins / Q000235:genetics; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
chemical_list: D029681:Arabidopsis Proteins; D017382:Reactive Oxygen Species; D060431:Thylakoid Membrane Proteins; D005680:gamma-Aminobutyric Acid; D006861:Hydrogen Peroxide; C555298:APXT protein, Arabidopsis; D060387:Ascorbate Peroxidases; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1; C401141:glutamate decarboxylase 2