title: Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.
abstract: Compounds 8a-d have been designed as bioisosters of tariquidar for imaging P-gp expression and density by PET. The results displayed that compounds 8b and 8d could be considered potential P-gp/BCRP ligands suitable as (11)C and (18)F radiotracers, respectively.
authors: Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'A. Moro', via Orabona, 4, 70125 Bari, Italy.
authors: Marialessandra
authors: M
authors: Contino
authors: Laura
authors: L
authors: Zinzi
authors: Maria Grazia
authors: MG
authors: Perrone
authors: Marcello
authors: M
authors: Leopoldo
authors: Francesco
authors: F
authors: Berardi
authors: Roberto
authors: R
authors: Perrone
authors: Nicola Antonio
authors: NA
authors: Colabufo
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis*; D002250:Carbon Radioisotopes / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D011804:Quinolines; D019275:Radiopharmaceuticals; D013844:Thiazoles; C402343:tariquidar