title: [Inhibitory effects of Rhodiola plants and their oligomeric proanthocyanidins on tyrosinase and Abeta42 aggregation].
abstract: Tyrosinase is a key enzyme related to skin pigmentation disorders of elderly people, while self-aggregation of the amyloid-beta peptide, Abeta42, has been considered as a key event in the pathogenesis of Alzheimer's disease (AD). The present study was undertaken to investigate the inhibitory effects of 20 samples from Rhodiola species on tyrosinase and Abeta42 aggregation, and to isolate their corresponding bioactive components. The results demonstrated that the oligomeric proanthocyanidins (OPCs) commonly found in Rhodiola species were the major bioactive components corresponding to their anti-tyrosinase and anti-Abeta42 aggregation bioactivities. Salidroside, a representative compound of Rhodiola plants, proved not to be active in the present studies.
authors: School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors: Bo-Fan
authors: BF
authors: Chen
authors: Yan-Fang
authors: YF
authors: Yang
authors: Ying-Tao
authors: YT
authors: Zhang
mesh_terms: D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D044945:Proanthocyanidins / Q000302:isolation & purification / Q000494:pharmacology*; D029771:Rhodiola / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D010446:Peptide Fragments; D010636:Phenols; D044945:Proanthocyanidins; C075222:amyloid beta-protein (1-42); D014442:Monophenol Monooxygenase; C009172:rhodioloside