title: Expression patterns and adaptive functional diversity of vertebrate myoglobins.
abstract: Recent years have witnessed a new round of research on one of the most studied proteins - myoglobin (Mb), the oxygen (O2) carrier of skeletal and heart muscle. Two major discoveries have stimulated research in this field: 1) that Mb has additional protecting functions, such as the regulation of in vivo levels of the signaling molecule nitric oxide (NO) by scavenging and generating NO during normoxia and hypoxia, respectively; and 2) that Mb in vertebrates (particularly fish) is expressed as tissue-specific isoforms in other tissues than heart and skeletal muscle, such as vessel endothelium, liver and brain, as found in cyprinid fish. Furthermore, Mb has also been found to protect against oxidative stress after hypoxia and reoxygenation and to undergo allosteric, O2-linked S-nitrosation, as in rainbow trout. Overall, the emerging evidence, particularly from fish species, indicates that Mb fulfills a broader array of physiological functions in a wider range of different tissues than hitherto appreciated. This new knowledge helps to better understand how variations in Mb structure and function may correlate with differences in animals' lifestyles and hypoxia-tolerance. This review integrates old and new results on Mb expression patterns and functional properties amongst vertebrates and discusses how these may relate to adaptive variations in different species. This article is part of a special issue entitled: Oxygen Binding and Sensing Proteins.
authors: Department of Bioscience, Aarhus University, Denmark. signe.helbo@biology.au.dk
authors: Signe
authors: S
authors: Helbo
authors: Roy E
authors: RE
authors: Weber
authors: Angela
authors: A
authors: Fago
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D006321:Heart / Q000502:physiology*; D006801:Humans; D009211:Myoglobin / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D014714:Vertebrates / Q000378:metabolism*
chemical_list: D009211:Myoglobin; D009569:Nitric Oxide; D010100:Oxygen
keywords: CO; Cys; Facilitated diffusion; H(2)O(2); Hb; Hydrogen peroxide; Hypoxia; Mb; NO; NOS; Nitrite reductase; O(2); Oxygen affinity; P(50); PO(2); ROS; S-nitrosothiol; SNO; carbon monoxide; cysteine; hemoglobin; hydrogen peroxide; myoglobin; nitric oxide; nitric oxide synthase; oxygen; oxygen tension; reactive oxygen species; the O(2) tension at 50% saturation