title: Intra-articular injection of xanthan gum reduces pain and cartilage damage in a rat osteoarthritis model.
abstract: The objective of this study was to evaluate the alleviative effect of intra-articular (IA) injection of xanthan gum (XG) on pain and cartilage degradation in a model of monosodium iodoacetate (MIA)-induced knee osteoarthritis (OA). The rheological study and hyaluronidase (HAse) degradation analysis of XG injection were presented. The effect of pain relief was determined by measurements of paw withdrawal threshold and weight bearing by hind limbs. The protective effect on the cartilage was evaluated by gross morphological observation and histological evaluation of knee joints. The effect was investigated in two protocols: a therapeutic treatment protocol, and a prophylactic treatment protocol. Our results showed that HAse had no effect on the rheological properties of XG injection. Local XG administration in both protocols could reduce OA pain and alleviate the joint cartilage degradation induced by MIA. IA injection of XG might be an effective method for OA treatment in human.
authors: Key Laboratory of Chemical Biology of Natural Products (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors: Huarong
authors: H
authors: Shao
authors: Guanying
authors: G
authors: Han
authors: Peixue
authors: P
authors: Ling
authors: Xiqiang
authors: X
authors: Zhu
authors: Fengshan
authors: F
authors: Wang
authors: Lijuan
authors: L
authors: Zhao
authors: Fei
authors: F
authors: Liu
authors: Xia
authors: X
authors: Liu
authors: Guilan
authors: G
authors: Wang
authors: Yong
authors: Y
authors: Ying
authors: Tianmin
authors: T
authors: Zhang
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D007270:Injections, Intra-Articular; D019807:Iodoacetic Acid / Q000009:adverse effects; D008297:Male; D010003:Osteoarthritis / Q000139:chemically induced / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D010146:Pain / Q000150:complications* / Q000188:drug therapy*; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012212:Rheology
chemical_list: D011135:Polysaccharides, Bacterial; C002563:xanthan gum; D019807:Iodoacetic Acid