title: Dissolution profile of 24 levofloxacin (100 mg) tablets.
abstract: Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.
authors: Department of Practical Pharmacy, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
authors: Kayoko
authors: K
authors: Maezawa
authors: Ryo
authors: R
authors: Yajima
authors: Tomoko
authors: T
authors: Terajima
authors: Junko
authors: J
authors: Kizu
authors: Seiji
authors: S
authors: Hori
mesh_terms: D002626:Chemistry, Pharmaceutical; D016568:Drugs, Generic / Q000737:chemistry / Q000592:standards; D007564:Japan; D064704:Levofloxacin / Q000737:chemistry* / Q000592:standards; D012995:Solubility; D013607:Tablets / Q000737:chemistry / Q000592:standards
chemical_list: D016568:Drugs, Generic; D013607:Tablets; D064704:Levofloxacin