title: Circadian control of the immune system.
abstract: Circadian rhythms, which have long been known to play crucial roles in physiology, are emerging as important regulators of specific immune functions. Circadian oscillations of immune mediators coincide with the activity of the immune system, possibly allowing the host to anticipate and handle microbial threats more efficiently. These oscillations may also help to promote tissue recovery and the clearance of potentially harmful cellular elements from the circulation. This Review summarizes the current knowledge of circadian rhythms in the immune system and provides an outlook on potential future implications.
authors: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA. christoph.scheiermann@med.uni-muenchen.de
authors: Christoph
authors: C
authors: Scheiermann
authors: Yuya
authors: Y
authors: Kunisaki
authors: Paul S
authors: PS
authors: Frenette
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology; D000818:Animals; D001772:Blood Cell Count; D021081:Chronobiology Disorders / Q000276:immunology; D002940:Circadian Rhythm / Q000276:immunology*; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology; D004198:Disease Susceptibility; D055870:Drug Chronotherapy; D025461:Feedback, Physiological / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D006728:Hormones / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D056724:Immunity, Humoral / Q000502:physiology; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D008322:Mammals / Q000276:immunology / Q000502:physiology; D051379:Mice; D018448:Models, Immunological; D014158:Transcription, Genetic / Q000502:physiology
chemical_list: D056925:Circadian Rhythm Signaling Peptides and Proteins; D006728:Hormones
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