title: Improved total synthesis of incednam.
abstract: An alternative and improved total synthesis of incednam, the aglycon of the 24-membered macrolactam glycoside antibiotic incednine, was accomplished. The synthesis was realized via construction of the 24-membered macrocycle using intramolecular ring-closing olefin metathesis reaction as a key step.
authors: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
authors: Akira
authors: A
authors: Takada
authors: Kanjiro
authors: K
authors: Uda
authors: Takashi
authors: T
authors: Ohtani
authors: Shinya
authors: S
authors: Tsukamoto
authors: Daisuke
authors: D
authors: Takahashi
authors: Kazunobu
authors: K
authors: Toshima
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D004187:Disaccharides / Q000737:chemistry; D007769:Lactams / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; D000900:Anti-Bacterial Agents; D004187:Disaccharides; D007769:Lactams; D047028:Macrocyclic Compounds; C555192:incednam; C527896:incednine