title: Maximizing the benefits of off-target kinase inhibitor activity.
abstract: Investigators report the identification of novel mutant-specific inhibition of EGF receptor (EGFR) T790M by bis-indole-based inhibitors of protein kinase C using a small-molecule cancer cell line-based screening platform. This study shows the power of high-throughput drug screening in cancer cell lines and provides new lead scaffolds for optimization against resistant EGFR mutants in lung cancer.
authors: Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232, USA.
authors: Monica
authors: M
authors: Red Brewer
authors: William
authors: W
authors: Pao
mesh_terms: D000818:Animals; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics*; D006801:Humans; D009154:Mutation; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*
chemical_list: D047428:Protein Kinase Inhibitors; D066246:ErbB Receptors