title: Left atrial size is independently associated with cognitive function.
abstract: Left atrial (LA) diameter is easily attainable from echocardiograph and sensitive to underlying cardiovascular disease severity, although its association with neurocognitive outcomes is not well understood. Fifty older adults (64.50 ± 9.41 years), recruited from outpatient cardiology clinics and local papers who underwent magnetic resonance imaging, were administered the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and completed psychosocial self-report measures. LA diameter was quantified using echocardiogram. Hierarchical regression analyses revealed that greater LA size was independently associated with reduced performance on the following RBANS composites: language, delayed memory, and total index (p < 0.05 for all). Hierarchical regression analysis demonstrated no significant association between LA diameter and whole brain volume (p > 0.05). The current study suggests that greater LA size is associated with cognitive dysfunction in older adults and prospective studies are needed to validate these findings and elucidate underlying mechanisms.
authors: Department of Psychology, Kent State University, Kent, OH 44242, USA. Malosco@kent.edu
authors: Michael L
authors: ML
authors: Alosco
authors: John
authors: J
authors: Gunstad
authors: Beth A
authors: BA
authors: Jerskey
authors: Uraina S
authors: US
authors: Clark
authors: Jason J
authors: JJ
authors: Hassenstab
authors: Xiaomeng
authors: X
authors: Xu
authors: Athena
authors: A
authors: Poppas
authors: Ronald A
authors: RA
authors: Cohen
authors: Lawrence H
authors: LH
authors: Sweet
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D002318:Cardiovascular Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000523:psychology*; D003072:Cognition Disorders / Q000150:complications / Q000473:pathology*; D003863:Depression / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D004452:Echocardiography; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D009483:Neuropsychological Tests; D012044:Regression Analysis
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