title: Omega-3 fatty acid-derived resolvins and protectins in inflammation resolution and leukocyte functions: targeting novel lipid mediator pathways in mitigation of acute kidney injury.
abstract: Inflammation, in conjunction with leukocytes, plays a key role in most acute kidney injury (AKI). Non-resolving renal inflammation leads to chronic fibrosis and renal failure. Resolvin D series (RvDs) and E series (RvEs), protectins, and maresins (MaRs) are endogenous omega-3 fatty acid-derived lipid mediators (LMs) that potently promote inflammation resolution by shortening neutrophil life span and promoting macrophage (Mf) non-phelogistic phagocytosis of apoptotic cells and the subsequent exit of Mfs from inflammatory tissue. 14S,21R-dihydroxy docosahexaenoic acid (14S,21R-diHDHA), a Mf-produced autacrine, reprograms Mfs to rescue vascular endothelia. RvD1, RvE1, or 14S,21R-diHDHA also switches Mfs to the phenotype that produces pro-resolving interleukin-10. RvDs or protectin/neuroprotectin D1 (PD1/NPD1) inhibits neutrophil infiltration into injured kidneys, blocks toll-like receptor -mediated inflammatory activation of Mfs and mitigates renal functions. RvDs also repress renal interstitial fibrosis, and PD1 promotes renoprotective heme-oxygenase-1 expression. These findings provide novel approaches for targeting inflammation resolution and LMs or modulation of LM-associated pathways for developing better clinical treatments for AKI.
authors: Neuroscience Center of Excellence, Health Science Center, Louisiana State University New Orleans, LA, USA.
authors: Song
authors: S
authors: Hong
authors: Yan
authors: Y
authors: Lu
keywords: 14S,21R-diHDHA; fibrosis; inflammation-resolution; kidney-injury; leukocytes; maresins; protectins/neuroprotectins; resolvins
references: Am J Pathol. 2011 Sep;179(3):1243-56
references: 21762674
references: Am J Pathol. 2011 Oct;179(4):1780-91
references: 21839062
references: J Biol Chem. 2000 Sep 8;275(36):27566-75
references: 10869343
references: Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8491-6
references: 15152078
references: Nature. 2007 Jun 14;447(7146):869-74
references: 17568749
references: Kidney Int. 2004 Apr;65(4):1145-54
references: 15086453
references: J Exp Med. 2005 Mar 7;201(5):713-22
references: 15753205
references: Eur J Immunol. 2011 Feb;41(2):366-79
references: 21268007
references: Am J Kidney Dis. 2002 Aug;40(2):275-9
references: 12148099
references: Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14983-8
references: 22927428
references: J Biol Chem. 1997 Mar 14;272(11):6972-8
references: 9054386
references: J Immunol. 2008 Mar 1;180(5):3512-9
references: 18292578
references: Am J Physiol Cell Physiol. 2003 Apr;284(4):C888-96
references: 12456400
references: Br J Pharmacol. 2009 Oct;158(4):947-59
references: 19785661
references: J Biol Chem. 2006 Aug 11;281(32):22847-54
references: 16757471
references: J Leukoc Biol. 2007 Jan;81(1):28-37
references: 16943388
references: Chem Rev. 2011 Oct 12;111(10):5922-43
references: 21766791
references: ScientificWorldJournal. 2010 Jul 07;10:1370-85
references: 20623097
references: Semin Nephrol. 2010 May;30(3):302-17
references: 20620674
references: J Exp Med. 1994 Jul 1;180(1):253-60
references: 8006586
references: J Clin Invest. 2005 Oct;115(10):2774-83
references: 16151530
references: Kidney Int. 2012 Jun;81(12):1199-211
references: 22297670
references: Brain Pathol. 2005 Apr;15(2):159-66
references: 15912889
references: J Am Soc Nephrol. 1992 Dec;3(6):1312-20
references: 1477327
references: J Immunol. 2006 Feb 1;176(3):1848-59
references: 16424216
references: Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3613-20
references: 19443724
references: Nature. 2009 Oct 29;461(7268):1287-91
references: 19865173
references: J Am Soc Nephrol. 2003 Feb;14(2):389-96
references: 12538739
references: J Am Coll Nutr. 2002 Dec;21(6):495-505
references: 12480795
references: J Exp Med. 2000 Oct 16;192(8):1197-204
references: 11034610
references: J Immunol. 2003 Jun 15;170(12):6266-72
references: 12794159
references: J Exp Med. 2009 Jan 16;206(1):15-23
references: 19103881
references: J Clin Invest. 2011 Nov;121(11):4210-21
references: 22045571
references: Biochem Biophys Res Commun. 2005 Jun 24;332(1):11-6
references: 15896292
references: Kidney Int. 1995 Aug;48(2):439-48
references: 7564111
references: Lipids. 1999 Apr;34(4):317-24
references: 10443964
references: J Lipid Res. 2010 May;51(5):923-32
references: 19965612
references: Prostaglandins Leukot Essent Fatty Acids. 2011 Jan-Feb;84(1-2):43-50
references: 20869861
references: Mol Neurobiol. 2011 Oct;44(2):216-22
references: 21918832
references: Proc Natl Acad Sci U S A. 2005 May 24;102(21):7671-6
references: 15890784
references: Prostaglandins Leukot Essent Fatty Acids. 2010 Jan;82(1):27-34
references: 19931440
references: Am J Physiol Renal Physiol. 2005 Jul;289(1):F31-42
references: 15713913
references: Clin Exp Nephrol. 2012 Oct;16(5):672-8
references: 22926697
references: Stem Cells Dev. 2012 May 1;21(7):1187-99
references: 21846180
references: Zhongguo Dang Dai Er Ke Za Zhi. 2006 Jun;8(3):225-30
references: 16787597
references: J Immunol. 2005 Apr 1;174(7):4345-55
references: 15778399
references: J Immunol. 2009 Mar 1;182(5):3223-32
references: 19234220
references: J Immunol. 2003 Sep 15;171(6):3210-5
references: 12960350
references: Nephrol Dial Transplant. 2008 Mar;23(3):842-52
references: 17984109
references: Trends Immunol. 2007 Apr;28(4):176-83
references: 17337246
references: J Biol Chem. 2007 Mar 30;282(13):9323-9334
references: 17244615
references: Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):127-9
references: 23022417
references: Kidney Int. 2007 Aug;72(3):234-6
references: 17653230
references: J Exp Med. 2002 Oct 21;196(8):1025-37
references: 12391014
references: Exp Eye Res. 2010 Jun;90(6):718-25
references: 20230819
references: Clin J Am Soc Nephrol. 2008 Sep;3(5):1526-33
references: 18701615
references: J Biol Chem. 2003 Apr 25;278(17):14677-87
references: 12590139
references: J Cell Biochem. 2010 Oct 1;111(2):266-73
references: 20506249
references: J Immunol. 2000 Feb 15;164(4):1663-7
references: 10657608
references: Front Immunol. 2012 Jan 31;3:4
references: 22566890
references: Immunol Res. 2010 Jul;47(1-3):78-85
references: 20082154
references: J Immunol. 2006 Nov 1;177(9):5902-11
references: 17056514
references: FASEB J. 2011 May;25(5):1441-8
references: 21532053
references: J Immunol. 2007 Mar 15;178(6):3912-7
references: 17339491
references: J Biol Chem. 2010 Jan 29;285(5):3451-61
references: 19906641
references: J Investig Med. 2004 Jul;52(5):310-4
references: 15551653
references: J Biol Chem. 2003 Mar 28;278(13):10879-84
references: 12500974
references: J Biol Chem. 2003 Oct 31;278(44):43807-17
references: 12923200
references: J Am Soc Nephrol. 2011 Feb;22(2):317-26
references: 21289217
references: Biochem Biophys Res Commun. 1984 Dec 14;125(2):741-7
references: 6240268
references: FASEB J. 2011 Sep;25(9):2967-79
references: 21628447
references: J Am Soc Nephrol. 2002 Jun;13(6):1657-62
references: 12039996
references: Exp Neurol. 2012 Jul;236(1):122-30
references: 22542947
references: Lancet. 2012 Aug 25;380(9843):756-66
references: 22617274
references: J Biol Chem. 2011 Feb 11;286(6):4443-53
references: 21112969
references: Semin Nephrol. 2010 May;30(3):234-54
references: 20620669
references: J Biol Chem. 2005 Dec 30;280(52):43079-86
references: 16216871