title: Perinatal programming of metabolic diseases: role of insulin in the development of hypothalamic neurocircuits.
abstract: It is increasingly accepted that the metabolic future of an individual can be programmed as early as at developmental stages. For instance, offspring of diabetic mothers have a greater risk of becoming obese and diabetic later in life. Animal studies have demonstrated that hyperinsulinemia and/or hyperglycemia during perinatal life permanently impair the organization and long-term function of hypothalamic networks that control appetite and glucose homeostasis. This review summarizes the main findings regarding the key regulatory roles of perinatal insulin and glucose levels on hypothalamic development and on long-term programming of metabolic diseases reported in different rodent models.
authors: Department of Mouse Genetics and Metabolism, University Hospital Cologne and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Köln 50674, Germany.
authors: Sophie M
authors: SM
authors: Steculorum
authors: Merly C
authors: MC
authors: Vogt
authors: Jens C
authors: JC
authors: Brüning
mesh_terms: D000818:Animals; D004734:Energy Metabolism; D005260:Female; D007031:Hypothalamus / Q000196:embryology* / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D008659:Metabolic Diseases / Q000378:metabolism*; D023421:Models, Animal; D009415:Nerve Net / Q000196:embryology* / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D007328:Insulin