title: Atom-economical chemoselective synthesis of 1,4-enynes from terminal alkenes and propargylic alcohols catalyzed by Cu(OTf)2.
abstract: A novel and efficient Cu(OTf)2-catalyzed sp(3)-sp(2) C-C bond formation reaction through the direct coupling of propargylic alcohols with terminal alkenes has been realized under mild conditions. The reaction is tolerant to air and is atom-economical, in accordance with the concept of modern green chemistry. The present protocol provides an attractive approach to a diverse range of 1,4-enynes in high to excellent yields.
authors: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry & Chemical Engineering of Guangxi Normal University, Guilin 541004, People's Republic of China.
authors: Guo-Bao
authors: GB
authors: Huang
authors: Xu
authors: X
authors: Wang
authors: Ying-Ming
authors: YM
authors: Pan
authors: Heng-Shan
authors: HS
authors: Wang
authors: Gui-Yang
authors: GY
authors: Yao
authors: Ye
authors: Y
authors: Zhang
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D008698:Mesylates; D020005:Propanols; C028255:propargyl alcohol; C012077:trifluoromethanesulfonic acid