title: Comparison of carbohydrate and lipid oxidation during continuous and intermittent exercise in patients with chronic heart failure.
abstract: Skeletal muscle substrate oxidation was compared during moderate-intensity continuous exercise (MICE) and high-intensity intermittent exercise (HIIE) in patients with heart failure and reduced ejection fraction (HFREF). Eighteen patients (aged 60 ± 9 years; LVEF, 26 ± 7%) randomly performed MICE (22 minutes at 60% of peak power) and HIIE (30 seconds at 100% of peak power interspersed by 30 seconds' rest for 16 minutes). Carbohydrate and lipid oxidation calculated using the Frayn equation were 4.8- and 1.42-fold higher during MICE and 5- and 1.22-fold higher during HIIE (P < 0.0001). HIIE and MICE can similarly and favourably increase carbohydrate and lipid oxidation in patients with HFREF.
authors: Cardiovascular Rehabilitation and Prevention Centre (ÉPIC), Montreal Heart Institute and Université de Montréal, Montreal, Québec, Canad. mathieu.gayda@icm-mhi.org
authors: Mathieu
authors: M
authors: Gayda
authors: Eve
authors: E
authors: Normandin
authors: Philippe
authors: P
authors: Meyer
authors: Martin
authors: M
authors: Juneau
authors: Anil
authors: A
authors: Nigam
mesh_terms: D000368:Aged; D050260:Carbohydrate Metabolism / Q000502:physiology*; D002908:Chronic Disease; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006333:Heart Failure / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000502:physiology*