title: Pomegranate seed extract attenuates chemotherapy-induced liver damage in an experimental model of rabbits.
abstract: The aim of this study was to determine whether antioxidant pomegranate seed extract (PSE) has a preventive effect on cisplatin-induced hepatotoxicity. Rabbits were divided into 3 groups (n=6):1—Control group (0.9 % saline. i.p) 2—Cisplatin group (a single dose of cisplatin (5 mg/kg, i.p) 3— A single dose of cisplatin (5 mg/kg, i.p) + PSE (250 mg/kg/day, i.p) for 6 consecutive days before and 6 consecutive days after a single intraperitoneal dose of 5 mg/kg body weight cisplatin. Liver function enzymes and malondialdehyde (MDA) levels were found significantly higher in cisplatin group compared to control. Liver catalase (CAT) and glutathione peroxidase (GSH-PX) activities decreased with cisplatin treatment but glutathione (GSH) level was increased. In cisplatin + PSE group, liver function enzyme activities and tissue MDA levels were found lower than cisplatin group. PSE ameliorated cisplatin-induced pathological changes. As a result it was demonstrated that PSE has protective effects against cisplatin hepatotoxicity in rabbit.
authors: Faculty of Engineering, Department of Environmental Engineering, Tunceli University, Tunceli, Turkey. nurancyildirim@gmail.com
authors: N C
authors: NC
authors: Yildirim
authors: F M
authors: FM
authors: Kandemir
authors: S
authors: S
authors: Ceribasi
authors: M
authors: M
authors: Ozkaraca
authors: F
authors: F
authors: Benzer
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000975:Antioxidants / Q000302:isolation & purification / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002945:Cisplatin / Q000009:adverse effects*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D029561:Lythraceae / Q000737:chemistry*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D011817:Rabbits; D012639:Seeds / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D010936:Plant Extracts; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D002945:Cisplatin