title: Phytochemical constituents of Mongolian traditional medicinal plants, Chamaerhodos erecta and C. altaica, and its constituents prevents the extracellular matrix degradation factors.
abstract: Activity-guided isolation of the n-butanol fraction of Chamaerhodos erecta and water soluble fraction of C. altaica resulted in the isolation of 39 compounds, including new compounds identified as 4,5-dihydroxybenzaldehyde-3-O-β-D-glucopyranoside (1) from C. erecta and quercetin-3-O-β-D-glucuronopyranosyl-4'-O-β-D-glucopyranoside (2) from C. altaica. A total of 37 other compounds were identified based on physico-chemical properties and spectroscopic data. Antioxidative activity was evaluated using a DPPH radical-scavenging method, hyaluronidase inhibitory activity, and advanced glycation end products production inhibitory activity of isolated compounds. Some flavonols (4, 6, 9-11, 14, 15), catechins (18, 19), an amino acid (20), a lignan glucoside (23), and tannins (29-39) exhibited potential a free radical scavenging activity while the new compound (1) showed weak activity. A catechin (18) and some of the tannins (32, 33, 35, 36, 38) had moderate hyaluronidase inhibitory activity. Some of flavonoids and tannins prevented advanced glycation end products production, and the IC₅₀ of compounds 3, 9, 14-16, 33, 34, 36, 38, and 39 were determined.
authors: Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.
authors: Erdenechimeg
authors: E
authors: Selenge
authors: Gendaram
authors: G
authors: Odontuya
authors: Toshihiro
authors: T
authors: Murata
authors: Kenroh
authors: K
authors: Sasaki
authors: Kyoko
authors: K
authors: Kobayashi
authors: Javzan
authors: J
authors: Batkhuu
authors: Fumihiko
authors: F
authors: Yoshizaki
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D005109:Extracellular Matrix / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D044948:Flavonols / Q000737:chemistry / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors; D056785:Medicine, Mongolian Traditional; D064209:Phytochemicals / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology; D027824:Rosaceae / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D044948:Flavonols; D005960:Glucosides; D017127:Glycation End Products, Advanced; D064209:Phytochemicals; D010936:Plant Extracts; D011794:Quercetin; D006821:Hyaluronoglucosaminidase
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