title: Accuracy of volume measurement using 3D ultrasound and development of CT-3D US image fusion algorithm for prostate cancer radiotherapy.
abstract: OBJECTIVE
  To evaluate the accuracy of measuring volumes using three-dimensional ultrasound (3D US), and to verify the feasibility of the replacement of CT-MR fusion images with CT-3D US in radiotherapy treatment planning.
  
  
  METHODS
  Phantoms, consisting of water, contrast agent, and agarose, were manufactured. The volume was measured using 3D US, CT, and MR devices. A CT-3D US and MR-3D US image fusion software was developed using the Insight Toolkit library in order to acquire three-dimensional fusion images. The quality of the image fusion was evaluated using metric value and fusion images.
  
  
  RESULTS
  Volume measurement, using 3D US, shows a 2.8 ± 1.5% error, 4.4 ± 3.0% error for CT, and 3.1 ± 2.0% error for MR. The results imply that volume measurement using the 3D US devices has a similar accuracy level to that of CT and MR. Three-dimensional image fusion of CT-3D US and MR-3D US was successfully performed using phantom images. Moreover, MR-3D US image fusion was performed using human bladder images.
  
  
  CONCLUSIONS
  3D US could be used in the volume measurement of human bladders and prostates. CT-3D US image fusion could be used in monitoring the target position in each fraction of external beam radiation therapy. Moreover, the feasibility of replacing the CT-MR image fusion to the CT-3D US in radiotherapy treatment planning was verified.
authors: Department of Medical Sciences, Ewha Womans University, Seoul, Korea.
authors: Jihye
authors: J
authors: Baek
authors: Jangyoung
authors: J
authors: Huh
authors: Myungsoo
authors: M
authors: Kim
authors: So
authors: S
authors: Hyun An
authors: Yoonjin
authors: Y
authors: Oh
authors: DongYoung
authors: D
authors: Kim
authors: Kwangzoo
authors: K
authors: Chung
authors: Sungho
authors: S
authors: Cho
authors: Rena
authors: R
authors: Lee
mesh_terms: D000465:Algorithms; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D009929:Organ Size; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D047368:Tumor Burden; D014463:Ultrasonography / Q000379:methods*