title: Neutrophil gelatinase-associated lipocalin as an early marker of contrast-induced nephropathy after coronary angiography.
abstract: We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) was an early predictive biomarker of contrast-induced nephropathy (CIN) in patients with chronic kidney disease (n = 100) undergoing coronary catheterization. Serum creatinine (SCr) levels were measured at baseline, 24 hours, and 48 hours post procedure. Serum NGAL was measured preprocedure, 4 hours, and 24 hours post procedure. The frequency of CIN was 11%. In patients with CIN, SCr achieved significance only at 48 hours (P = .006), whereas serum NGAL increased ≥25% from baseline at 24 hours in 7 of 11 patients with CIN (P = .04) but did not change in the other 4. However, serum NGAL also rose ≥25% in 12 of 89 non-CIN patients. This subgroup could have had "incipient CIN." Serum NGAL delta value at baseline, 24 hours was superior to SCr for early diagnosis of CIN. In conclusion, serum NGAL is an early predictive biomarker for CIN.
authors: 1Nephrology Unit, Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
authors: Sabah Mohamed
authors: SM
authors: Alharazy
authors: Norella
authors: N
authors: Kong
authors: Rashidi
authors: R
authors: Saidin
authors: Abdul Halim Abdul
authors: AH
authors: Gafor
authors: Oteh
authors: O
authors: Maskon
authors: Marlyn
authors: M
authors: Mohd
authors: Syed Zulkifli Syed
authors: SZ
authors: Zakaria
mesh_terms: D000209:Acute-Phase Proteins; D015415:Biomarkers / Q000097:blood*; D006328:Cardiac Catheterization; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000097:blood*; D012372:ROC Curve; D051436:Renal Insufficiency, Chronic / Q000150:complications*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D003287:Contrast Media; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine
keywords: chronic kidney disease; contrast-induced nephropathy; coronary catheterization; neutrophil gelatinase-associated lipocalin