title: Uncinate fasciculus fractional anisotropy correlates with typical use of reappraisal in women but not men.
abstract: Emotion regulation refers to strategies through which individuals influence their experience and expression of emotions. Two typical strategies are reappraisal, a cognitive strategy for reframing the context of an emotional experience, and suppression, a behavioral strategy for inhibiting emotional responses. Functional neuroimaging studies have revealed that regions of the prefrontal cortex modulate amygdala reactivity during both strategies, but relatively greater downregulation of the amygdala occurs during reappraisal. Moreover, these studies demonstrated that engagement of this modulatory circuitry varies as a function of gender. The uncinate fasciculus is a major structural pathway connecting regions of the anterior temporal lobe, including the amygdala to inferior frontal regions, especially the orbitofrontal cortex. The objective of the current study was to map variability in the structural integrity of the uncinate fasciculus onto individual differences in self-reported typical use of reappraisal and suppression. Diffusion tensor imaging was used in 194 young adults to derive regional fractional anisotropy values for the right and left uncinate fasciculus. All participants also completed the Emotion Regulation Questionnaire. In women but not men, self-reported typical reappraisal use was positively correlated with fractional anisotropy values in a region of the left uncinate fasciculus within the orbitofrontal cortex. In contrast, typical use of suppression was not significantly correlated with fractional anisotropy in any region of the uncinate fasciculus in either men or women. Our data suggest that in women typical reappraisal use is specifically related to the integrity of white matter pathways linking the amygdala and prefrontal cortex.
authors: Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Institute for Genome Sciences & Policy, Duke University.
authors: Lisette A
authors: LA
authors: Zuurbier
authors: Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Institute for Genome Sciences & Policy, Duke University.
authors: Yuliya S
authors: YS
authors: Nikolova
authors: Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Institute for Genome Sciences & Policy, Duke University.
authors: Fredrik
authors: 0000-0002-6355-660X
authors: F
authors: Åhs
authors: Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Institute for Genome Sciences & Policy, Duke University.
authors: Ahmad R
authors: AR
authors: Hariri
mesh_terms: D000328:Adult; D000679:Amygdala / Q000502:physiology; D016880:Anisotropy; D054022:Cerebrum / Q000502:physiology*; D056324:Diffusion Tensor Imaging / Q000295:instrumentation / Q000379:methods*; D004644:Emotions / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D012737:Sex Factors; D055815:Young Adult
references: Neuroimage. 2006 Feb 1;29(3):721-33
references: 16249100
references: J Pers Soc Psychol. 1998 Jan;74(1):224-37
references: 9457784
references: J Cogn Neurosci. 2007 May;19(5):776-98
references: 17488204
references: Biol Psychiatry. 2009 Oct 1;66(7):691-4
references: 19362707
references: Curr Opin Neurobiol. 2006 Dec;16(6):723-7
references: 17084617
references: Neuroreport. 2003 Dec 19;14(18):2469-73
references: 14663212
references: Hum Brain Mapp. 2007 May;28(5):409-23
references: 17133391
references: Neuroimage. 2002 Sep;17(1):77-94
references: 12482069
references: Annu Rev Clin Psychol. 2011;7:63-85
references: 21219189
references: Biol Psychiatry. 2008 Dec 15;64(12):1088-92
references: 18814861
references: Hum Brain Mapp. 2010 May;31(5):758-69
references: 19957268
references: J Neurosci. 2007 Aug 15;27(33):8877-84
references: 17699669
references: Neuropsychopharmacology. 2012 Mar;37(4):959-67
references: 22089322
references: J Cogn Neurosci. 2002 Nov 15;14(8):1215-29
references: 12495527
references: Soc Cogn Affect Neurosci. 2007 Dec;2(4):303-12
references: 18985136
references: Biol Psychiatry. 2005 Feb 1;57(3):210-9
references: 15691521
references: Trends Cogn Sci. 2007 Oct;11(10):413-8
references: 17928261
references: Schizophr Res. 2009 May;110(1-3):119-26
references: 19328656
references: Soc Cogn Affect Neurosci. 2009 Dec;4(4):328-39
references: 20019072
references: Neuroimage. 2008 Feb 1;39(3):949-55
references: 17988894
references: Annu Rev Clin Psychol. 2012;8:161-87
references: 22035243
references: Neuropsychologia. 2011 Apr;49(5):1067-1082
references: 21345342
references: J Neurosci. 2006 Apr 19;26(16):4415-25
references: 16624961
references: J Pers Soc Psychol. 1998 Mar;74(3):686-703
references: 9523412
references: Health Psychol. 2000 Nov;19(6):586-92
references: 11129362
references: Group Process Intergroup Relat. 2008 Apr;11(2):143-162
references: 29743808
references: Neuron. 2008 Sep 25;59(6):1037-50
references: 18817740
references: Biol Psychiatry. 2009 Mar 1;65(5):367-73
references: 18930182
references: Neuroimage. 2004 Oct;23(2):483-99
references: 15488398
references: Neuropsychiatr Dis Treat. 2007;3(5):669-74
references: 19300596
references: Acta Neurochir (Wien). 1992;115(3-4):143-8
references: 1605083
references: J Cogn Neurosci. 2002 Aug 15;14(6):913-21
references: 12191458
references: Biol Psychol. 2011 Mar;86(3):379-82
references: 21138751
references: Neuroimage. 2004;23 Suppl 1:S208-19
references: 15501092
references: Arch Gen Psychiatry. 1998 May;55(5):405-13
references: 9596043
references: Neuroscience. 2004;129(2):361-9
references: 15501593
references: Biol Psychiatry. 2003 Mar 15;53(6):502-10
references: 12644355
references: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8301-6
references: 10393989
references: Ann N Y Acad Sci. 2005 Dec;1064:37-49
references: 16394146
references: BMC Neurosci. 2012 Jan 04;13:4
references: 22217209
references: JAMA. 1996 Jul 24-31;276(4):293-9
references: 8656541
references: Science. 2000 Jul 28;289(5479):591-4
references: 10915615
references: Neuroimage. 2007 Feb 1;34(3):905-23
references: 17126037
references: Hum Brain Mapp. 2013 Feb;34(2):437-46
references: 22076860
references: J Pers Soc Psychol. 2003 Aug;85(2):348-62
references: 12916575
references: J Neurosci. 2009 Sep 16;29(37):11614-8
references: 19759308
references: J Pers Soc Psychol. 1992 Apr;62(4):676-87
references: 1583591
references: Biol Psychiatry. 2008 Mar 15;63(6):577-86
references: 17888411
references: Neuroimage. 2010 Oct 1;52(4):1289-301
references: 20570617
references: J Pers Soc Psychol. 1998 May;74(5):1310-6
references: 9599445
references: Brain. 1999 May;122 ( Pt 5):981-91
references: 10355680