title: Clinical symptoms in adults with selective IgA deficiency: a case-control study.
abstract: Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency in Caucasians with a prevalence of 1/600 and is generally considered a mild disorder. In this study, the clinical status of 32 adults with SIgAD was investigated and compared to 63 age- and gender matched controls, randomly selected from a population database. The SIgAD individuals reported significantly more often contracting various upper and lower respiratory infections, with 8 (25.0 %) having been diagnosed with ≥1 pneumonia in the preceding two years, compared to one (1.6 %) control (p < 0.001). Furthermore, the SIgAD individuals were found to have increased proneness to infections and increased prevalence of allergic diseases and autoimmunity, with a total of 84.4 % being affected by any of these diseases, compared to 47.6 % of the controls (p < 0.01). This study challenges the common statement of SIgAD being a mild form of immunodeficiency. It also highlights the importance of using matched controls in PID clinical research to better detect clinically important manifestations.
authors: Department of Medicine, University of Iceland, Reykjavík, Iceland. gudmhj@landspitali.is
authors: G H
authors: GH
authors: Jorgensen
authors: A
authors: A
authors: Gardulf
authors: M I
authors: MI
authors: Sigurdsson
authors: S Th
authors: ST
authors: Sigurdardottir
authors: I
authors: I
authors: Thorsteinsdottir
authors: S
authors: S
authors: Gudmundsson
authors: L
authors: L
authors: Hammarström
authors: B R
authors: BR
authors: Ludviksson
mesh_terms: D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D007055:Iceland; D017098:IgA Deficiency / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012141:Respiratory Tract Infections / Q000453:epidemiology*; D012306:Risk; D011795:Surveys and Questionnaires
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