title: Improving radiotherapy quality assurance in clinical trials: assessment of target volume delineation of the pre-accrual benchmark case.
abstract: As the complexity of radiotherapy (RT) trials increases, issues surrounding target volume delineation will become more important. Some form of outlining assessment prior to trial entry is increasingly being mandated in UK RT trials. This document produced by the Outlining and Imaging Subgroup (OISG) of the National Cancer Research Institute will address methods to reduce interobserver variation in clinical trials and how to conduct an assessment of outlining through a pre-accrual benchmark case. We review currently available methods of describing the variation and identify areas where further work is needed. The OISG would encourage ongoing discussion with chief investigators in order to provide advice on individual aspects of benchmark case assessment for current and future trials.
authors: Department of Clinical Oncology, Singleton Hospital, Swansea, UK. sarah.gwynne@wales.nhs.uk
authors: S
authors: S
authors: Gwynne
authors: E
authors: E
authors: Spezi
authors: D
authors: D
authors: Sebag-Montefiore
authors: S
authors: S
authors: Mukherjee
authors: E
authors: E
authors: Miles
authors: J
authors: J
authors: Conibear
authors: J
authors: J
authors: Staffurth
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards*; D019983:Guideline Adherence; D006801:Humans; D011785:Quality Assurance, Health Care / Q000592:standards*; D058996:Quality Improvement / Q000592:standards*; D011878:Radiotherapy / Q000592:standards*; D061089:Radiotherapy, Image-Guided / Q000592:standards*; D006113:United Kingdom; D054928:Validation Studies as Topic
references: Int J Radiat Oncol Biol Phys. 1999 Jul 1;44(4):931-5
references: 10386652
references: Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):809-16
references: 21277694
references: Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):481-9
references: 20400244
references: Radiat Oncol. 2011 Sep 19;6:118
references: 21929770
references: Clin Oncol (R Coll Radiol). 2010 Sep;22(7):515-25
references: 20554168
references: Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):990-3
references: 19345515
references: Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1923-9
references: 21514071
references: Int J Radiat Oncol Biol Phys. 2001 Apr 1;49(5):1399-408
references: 11286848
references: Radiother Oncol. 2008 Jan;86(1):43-7
references: 18054103
references: Radiother Oncol. 2002 Jan;62(1):37-49
references: 11830311
references: Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1166-70
references: 19836158
references: Br J Radiol. 2010 Jan;83(985):44-51
references: 19620177
references: Strahlenther Onkol. 2003 Jan;179(1):21-30
references: 12540981
references: IEEE Trans Med Imaging. 2004 Jul;23(7):903-21
references: 15250643
references: Radiother Oncol. 2012 Jan;102(1):14-21
references: 21903287
references: Clin Oncol (R Coll Radiol). 2005 Sep;17(6):456-64
references: 16149290
references: Radiother Oncol. 2003 Nov;69(2):189-94
references: 14643957
references: Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):361-8
references: 19394158
references: Radiother Oncol. 2009 Dec;93(3):447-53
references: 19765847
references: Radiother Oncol. 1999 Dec;53(3):247-55
references: 10660205
references: Crit Rev Oncol Hematol. 2009 Apr;70(1):24-38
references: 18768328
references: Strahlenther Onkol. 2012 Feb;188(2):160-7
references: 22281878
references: Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):41-8
references: 17707265
references: Radiother Oncol. 1998 Apr;47(1):37-44
references: 9632290
references: J Clin Oncol. 2010 Jun 20;28(18):2996-3001
references: 20479390
references: Radiother Oncol. 2010 May;95(2):218-24
references: 20378192
references: Br J Radiol. 2009 Jul;82(979):585-94
references: 19332518
references: Int J Radiat Oncol Biol Phys. 2009 Jun 1;74(2):377-82
references: 18947941
references: Semin Radiat Oncol. 2004 Jan;14(1):52-64
references: 14752733
references: Radiother Oncol. 2000 Jul;56(1):73-83
references: 10869758
references: Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):334-9
references: 16168828
references: Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):369-78
references: 19515511
references: Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):379-85
references: 19467804
references: Radiother Oncol. 2010 Dec;97(3):572-8
references: 20708285