title: Streptococcus mutans: a new Gram-positive paradigm?
abstract: Despite the enormous contributions of the bacterial paradigms Escherichia coli and Bacillus subtilis to basic and applied research, it is well known that no single organism can be a perfect representative of all other species. However, given that some bacteria are difficult, or virtually impossible, to cultivate in the laboratory, that some are recalcitrant to genetic and molecular manipulation, and that others can be extremely dangerous to manipulate, the use of model organisms will continue to play an important role in the development of basic research. In particular, model organisms are very useful for providing a better understanding of the biology of closely related species. Here, we discuss how the lifestyle, the availability of suitable in vitro and in vivo systems, and a thorough understanding of the genetics, biochemistry and physiology of the dental pathogen Streptococcus mutans have greatly advanced our understanding of important areas in the field of bacteriology such as interspecies biofilms, competence development and stress responses. In this article, we provide an argument that places S. mutans, an organism that evolved in close association with the human host, as a novel Gram-positive model organism.
authors: Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors: José A
authors: JA
authors: Lemos
authors: Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors: Robert G
authors: RG
authors: Quivey
authors: Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors: Hyun
authors: H
authors: Koo
authors: Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors: Jacqueline
authors: J
authors: Abranches
mesh_terms: D018441:Biofilms / Q000254:growth & development; D061269:DNA Transformation Competence; D006801:Humans; D013295:Streptococcus mutans / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology*; D013312:Stress, Physiological
references: J Bacteriol. 2004 Jul;186(13):4152-8
references: 15205416
references: Microbiology (Reading). 2012 Dec;158(Pt 12):2903-2916
references: 23082034
references: Mol Microbiol. 2007 Sep;65(6):1568-81
references: 17714452
references: Appl Environ Microbiol. 1992 Jul;58(7):2287-91
references: 1386211
references: J Dent Res. 1998 Mar;77(3):445-52
references: 9496917
references: J Dent Res. 2005 Nov;84(11):1016-20
references: 16246933
references: J Bacteriol. 2003 Oct;185(20):5967-75
references: 14526007
references: J Dent Res. 2012 Feb;91(2):133-41
references: 21743034
references: Appl Environ Microbiol. 1991 Apr;57(4):1134-8
references: 1829347
references: Front Biosci. 2002 Aug 01;7:d1798-814
references: 12133809
references: Oral Surg Oral Med Oral Pathol. 1978 Apr;45(4):549-59
references: 273846
references: J Clin Microbiol. 2011 Apr;49(4):1464-74
references: 21289150
references: Plasmid. 2001 Jan;45(1):31-6
references: 11319929
references: J Proteome Res. 2010 Dec 3;9(12):6605-14
references: 20858015
references: J Bacteriol. 2009 Jan;191(2):616-24
references: 18996989
references: Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6656-61
references: 19366667
references: J Dent Res. 1996 Aug;75(8):1572-7
references: 8906125
references: J Bacteriol. 2010 Mar;192(5):1444-54
references: 20023010
references: Appl Environ Microbiol. 2011 Sep;77(18):6357-67
references: 21803906
references: Microbiol Mol Biol Rev. 2007 Dec;71(4):653-70
references: 18063722
references: J Bacteriol. 2010 May;192(10):2546-56
references: 20233935
references: Methods Mol Biol. 2010;666:87-102
references: 20717780
references: Mol Microbiol. 2009 Nov;74(4):888-902
references: 19818020
references: Crit Rev Oral Biol Med. 2003;14(2):89-99
references: 12764072
references: Mol Microbiol. 2009 May;72(4):905-17
references: 19400789
references: Infect Immun. 1977 Dec;18(3):726-34
references: 591064
references: PLoS One. 2012;7(9):e45795
references: 23049864
references: PLoS One. 2012;7(10):e47722
references: 23091642
references: Annu Rev Biochem. 2001;70:755-75
references: 11395422
references: Mol Microbiol. 2010 Nov;78(3):589-606
references: 20969646
references: J Gen Microbiol. 1986 May;132(5):1205-14
references: 3095488
references: Can J Microbiol. 2011 Jan;57(1):1-20
references: 21217792
references: J Microbiol Methods. 2002 Apr;49(2):193-205
references: 11830305
references: Oral Microbiol Immunol. 2007 Apr;22(2):95-102
references: 17311632
references: Appl Environ Microbiol. 2008 Apr;74(7):2037-42
references: 18263742
references: Infect Immun. 2003 Dec;71(12):7188-92
references: 14638814
references: J Bacteriol. 2010 Jun;192(12):3024-32
references: 20233920
references: Microbiol Mol Biol Rev. 2009 Sep;73(3):407-50, Table of Contents
references: 19721085
references: Mol Microbiol. 2012 Oct;86(2):258-72
references: 22845615
references: PLoS One. 2011;6(8):e23479
references: 21858139
references: Infect Immun. 2006 Mar;74(3):1631-42
references: 16495534
references: Curr Issues Mol Biol. 2005 Jan;7(1):95-107
references: 15580782
references: Mol Microbiol. 2012 Jul;85(2):361-77
references: 22651851
references: J Dent Res. 1989 May;68(5):750-60
references: 2654229
references: Nat Struct Mol Biol. 2010 Oct;17(10):1188-94
references: 20818390
references: Mol Microbiol. 2011 Jul;81(2):305-14
references: 21635580
references: Proc Soc Exp Biol Med. 1965 Mar;118:766-70
references: 14264552
references: J Bacteriol. 2008 Jul;190(13):4632-40
references: 18441055
references: J Dent Res. 1987 Jun;66(6):1095-8
references: 2887601
references: J Bacteriol. 2009 Apr;191(7):2248-56
references: 19168608
references: Adv Dent Res. 1994 Jul;8(2):263-71
references: 7865085
references: Microbiology (Reading). 2008 Nov;154(Pt 11):3247-3255
references: 18957579
references: Microbiology (Reading). 2001 Oct;147(Pt 10):2841-2848
references: 11577162
references: Infect Immun. 2011 Jun;79(6):2277-84
references: 21422186
references: Trends Microbiol. 2005 Jan;13(1):3-6
references: 15639624
references: Infect Immun. 2004 Mar;72(3):1431-40
references: 14977948
references: Mol Microbiol. 2010 Mar;75(5):1145-58
references: 20487301
references: J Bacteriol. 2008 Apr;190(7):2340-9
references: 18223086
references: J Clin Microbiol. 2010 Nov;48(11):4121-8
references: 20826648
references: Future Microbiol. 2010 Mar;5(3):403-17
references: 20210551
references: Mol Microbiol. 2009 Apr;72(2):380-98
references: 19298370
references: Infect Immun. 1993 Sep;61(9):3811-7
references: 8359902
references: Annu Rev Microbiol. 2008;62:35-51
references: 18454629
references: Infect Immun. 2007 Mar;75(3):1537-9
references: 17220314
references: Methods Enzymol. 1999;310:279-96
references: 10547800
references: Infect Immun. 2005 Jun;73(6):3568-76
references: 15908386
references: Trends Microbiol. 2006 Aug;14(8):339-45
references: 16820295
references: J Am Dent Assoc. 1960 Jul;61:9-19
references: 13823312
references: Mol Microbiol. 2005 Jul;57(2):392-404
references: 15978073
references: Oral Microbiol Immunol. 2006 Apr;21(2):132-5
references: 16476024
references: Mol Oral Microbiol. 2012 Apr;27(2):57-69
references: 22394465
references: Mol Microbiol. 2007 Feb;63(3):872-80
references: 17302806
references: Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14434-9
references: 12397186
references: Mol Microbiol. 2008 Oct;70(1):197-208
references: 18699864
references: Microbiol Rev. 1986 Dec;50(4):353-80
references: 3540569
references: J Bacteriol. 2007 Mar;189(5):1582-8
references: 17172345
references: Mol Biol Evol. 2013 Apr;30(4):881-93
references: 23228887
references: Arch Oral Biol. 1998 Feb;43(2):103-10
references: 9602288
references: Crit Rev Oral Biol Med. 2001;12(4):301-14
references: 11603503
references: Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17466-71
references: 16293689
references: Nature. 1992 Oct 22;359(6397):744-6
references: 1331806
references: J Bacteriol. 2009 Apr;191(7):2153-62
references: 19168613
references: Infect Immun. 1986 Aug;53(2):331-8
references: 3015800
references: Caries Res. 1998;32(6):456-62
references: 9745120
references: Infect Immun. 1992 Jan;60(1):284-95
references: 1530843
references: Appl Environ Microbiol. 2003 Aug;69(8):4760-9
references: 12902269
references: Microbiology (Reading). 2011 Sep;157(Pt 9):2433-2444
references: 21565931
references: J Biol Chem. 2002 Nov 22;277(47):44809-16
references: 12237320
references: J Dent Res. 2011 Nov;90(11):1298-305
references: 21868693
references: J Am Dent Assoc. 1955 Mar;50(3):259-72
references: 13232956
references: Mol Microbiol. 2008 Jan;67(2):291-304
references: 18067544
references: Compend Contin Educ Dent. 2010 Mar;31(2):104-6, 108, 110 passim; quiz 124, 138
references: 20344897
references: Caries Res. 2011;45(1):69-86
references: 21346355
references: J Clin Microbiol. 2002 Mar;40(3):1001-9
references: 11880430
references: Caries Res. 2005 Nov-Dec;39(6):448-54
references: 16251788
references: Environ Microbiol. 2011 Dec;13(12):3077-87
references: 21906224
references: FEMS Microbiol Lett. 2000 Aug 1;189(1):89-92
references: 10913871
references: PLoS One. 2011 Jan 31;6(1):e16549
references: 21304986
references: PLoS Pathog. 2012;8(4):e1002623
references: 22496649
references: Mol Microbiol. 2006 Oct;62(1):187-200
references: 16987177