title: Synthesis and micellar mimic properties of bile acid trimers.
abstract: Two fan-shaped bile acid trimers have been synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) 'click chemistry', and their extraction experiments of cresol red sodium (CR) and pyrene were investigated in the polar and non-polar solvents, respectively. The transmission electron microscopy (TEM) results showed that the homogenous hollow capsules formed with the diameter size range of 40-70 nm in a solution of water and acetone. Thus the amphiphilicity of fan-shaped bile acid trimers might be used as the promising candidate in biological and drug delivery applications.
authors: Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors: Jinrong
authors: J
authors: Lu
authors: Chulong
authors: C
authors: Liu
authors: Jun
authors: J
authors: Hu
authors: Yong
authors: Y
authors: Ju
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D001647:Bile Acids and Salts / Q000138:chemical synthesis / Q000737:chemistry*; D057930:Click Chemistry; D006801:Humans; D008823:Micelles; D008968:Molecular Conformation
chemical_list: D000480:Alkynes; D001386:Azides; D001647:Bile Acids and Salts; D008823:Micelles