title: Correlation of aquaporin-1 water channel protein expression with tumor angiogenesis in human astrocytoma.
abstract: Aquaporin-1 (AQP1) is a water channel protein, widely expressed in epithelial and endothelial cells, known to be associated with invasion, angiogenesis, cell migration and formation of tumour oedema in several malignancies. We investigated the pattern of immunohistochemical expression of AQP1 in human astrocytomas and its role in tumour angiogenesis and infiltration. Immunohistochemical staining of AQP1 was performed in astrocytomas of grade II, III and IV. Intensity and pattern of expression were analysed. Non-neoplastic brain tissues served as control. There was a significant increase in the intensity of AQP1 expression from low-grade to high-grade astrocytomas (p<0.0001). Despite intense expression of AQP1 in astrocytoma grade IV, we observed strong regional differences. AQP1 up-regulation was predominantly located perivascularly, in areas of tumour infiltration, distant from the necrotic tumour core. AQP1 expression correlates with the grade of malignancy and is associated with angiogenesis, as well as with invasion of grade IV tumour in areas of tumour infiltration. Suppression of AQP1 expression could be a potential means of reducing invasion of glioma cells.
authors: Department of Neurosurgery, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany. nicolai.elhindy@uk-essen.de
authors: Nicolai
authors: N
authors: El Hindy
authors: Agnes
authors: A
authors: Bankfalvi
authors: Arne
authors: A
authors: Herring
authors: Michael
authors: M
authors: Adamzik
authors: Nicole
authors: N
authors: Lambertz
authors: Yuan
authors: Y
authors: Zhu
authors: Winfried
authors: W
authors: Siffert
authors: Ulrich
authors: U
authors: Sure
authors: I Erol
authors: IE
authors: Sandalcioglu
mesh_terms: D051398:Aquaporin 1 / Q000096:biosynthesis*; D001254:Astrocytoma / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D060787:Neoplasm Grading; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation
chemical_list: C496020:AQP1 protein, human; D014408:Biomarkers, Tumor; D051398:Aquaporin 1