title: Use of the PiCCO system in critically ill patients with septic shock and acute respiratory distress syndrome: a study protocol for a randomized controlled trial.
abstract: BACKGROUND
  Hemodynamic monitoring is very important in critically ill patients with shock or acute respiratory distress syndrome(ARDS). The PiCCO (Pulse index Contour Continuous Cardiac Output, Pulsion Medical Systems, Germany) system has been developed and used in critical care settings for several years. However, its impact on clinical outcomes remains unknown.
  
  
  METHODS
  The study is a randomized controlled multi-center trial. A total of 708 patients with ARDS, septic shock or both will be included from January 2012 to January 2014. Subjects will be randomized to receive PiCCO monitoring or not. Our primary end point is 30-day mortality, and secondary outcome measures include ICU length of stay, days on mechanical ventilation, days of vasoactive agent support, ICU-free survival days during a 30-day period, mechanical-ventilation-free survival days during a 30-day period, and maximum SOFA score during the first 7 days.
  
  
  CONCLUSIONS
  We investigate whether the use of PiCCO monitoring will improve patient outcomes in critically ill patients with ARDS or septic shock. This will provide additional data on hemodynamic monitoring and help clinicians to make decisions on the use of PiCCO.
  
  
  BACKGROUND
  http://www.clinicaltrials.gov NCT01526382.
authors: Department of Critical Care Medicine, Jinhua Municipal Central Hospital, 351 Mingyue Street, Jinhua City, Zhejiang, 3210002, PR China. zh_zhang1984@hotmail.com
authors: Zhongheng
authors: Z
authors: Zhang
authors: Xiao
authors: X
authors: Xu
authors: Min
authors: M
authors: Yao
authors: Huilan
authors: H
authors: Chen
authors: Hongying
authors: H
authors: Ni
authors: Haozhe
authors: H
authors: Fan
mesh_terms: D002302:Cardiac Output; D002681:China; D002985:Clinical Protocols; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness; D004867:Equipment Design; D006801:Humans; D007902:Length of Stay; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D063305:Organ Dysfunction Scores; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012107:Research Design; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D012772:Shock, Septic / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents
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