title: [High-resolution THz spectra of six biological and pharmaceutical materials].
abstract: The temperature dependent vibrational spectra of,three biological and pharmaceutical sets, genistein and biochanin A, clenbuterol hydrochloride and salbutamol, as well as ginseng R2 and R3, in the range of 0.2-4.5 THz (6.6-150.0 cm(-)) are presented over the temperature range from 295 to 77 K Although there are only some minor difference in their molecular structures, the spectra of two samples in every group are quite differences in both absorption band positions and their relative intensities, and display strong linewidth narrowing and frequency blue-shift with cooling. Au 77 K, 13 highly resolved spectral features for biochanin A were obtained and the sensitivity of the experiment allows detection of amounts as small as 1.9 x 10(-5) mol of ginseng R3. Such high-resolution THz fingerprint spectra provide a rapid, nondestructive and reliable method for the identification of these pharmaceutical settings molecules.
authors: School of Science, Minzu University of China, Beijing 100081, China. ypyang_cun@126.com
authors: Yu-Ping
authors: YP
authors: Yang
authors: Rui-Lin
authors: RL
authors: Dong
authors: Zhen-Wei
authors: ZW
authors: Zhang
mesh_terms: D000420:Albuterol / Q000737:chemistry*; D002976:Clenbuterol / Q000737:chemistry*; D019833:Genistein / Q000737:chemistry*; D036145:Ginsenosides / Q000737:chemistry*; D013057:Spectrum Analysis; D055053:Terahertz Radiation
chemical_list: D036145:Ginsenosides; C048026:ginsenoside Rb2; C044463:ginsenoside Rb3; D019833:Genistein; D000420:Albuterol; C004541:biochanin A; D002976:Clenbuterol