title: [Hepatic encephalopathy and colon pathology in liver cirrhosis].
abstract: to define a role of structural and functional changes of a colon, expression indicators of epithelial cells of mucous coat of colon that produce serotonin and hromogranin-A at in encephalopathy development at liver cirrhoses. We have examined 146 patients with liver cirrhosis of various classes using the clinical, endoscopic, morphologic and immunohistochemical methods. It is established that with increase of a class of a cirrhosis frequency of revealing of a hepatic encephalopathy, structural changes, degree dysbacteriosis of a colon. Progressing of a hepatic encephalopathy at liver cirrhoses associates with development destructive and atrophic changes of a mucous membrane of a colon and a dysbacteriosis. The increase in the morphometric rates of epithelial cells of mucous coat of colon that produce serotonin and hromogranin-A at liver cirrhoses plays a part in development of a manifesting of a hepatic encephalopathy.
authors: M V
authors: MV
authors: Safonova
authors: I V
authors: IV
authors: Kozlova
authors: V V
authors: VV
authors: Ovsiannikova
authors: I M
authors: IM
authors: Kvetnoĭ
mesh_terms: D053379:Chromogranin A / Q000378:metabolism*; D003106:Colon / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D003108:Colonic Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006501:Hepatic Encephalopathy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000378:metabolism*
chemical_list: D053379:Chromogranin A; D012701:Serotonin