title: Phase-sensitive swept-source optical coherence tomography imaging of the human retina with a vertical cavity surface-emitting laser light source.
abstract: Despite the challenges in achieving high phase stability, Doppler swept-source/Fourier-domain optical coherence tomography (OCT) has advantages of less fringe washout and faster imaging speeds compared to spectral/Fourier-domain detection. This Letter demonstrates swept-source OCT with a vertical cavity surface-emitting laser light source at 400 kHz sweep rate for phase-sensitive Doppler imaging, measuring pulsatile total retinal blood flow with high sensitivity and phase stability. A robust, simple, and computationally efficient phase stabilization approach for phase-sensitive swept-source imaging is also presented.
authors: Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors: WooJhon
authors: W
authors: Choi
authors: Benjamin
authors: B
authors: Potsaid
authors: Vijaysekhar
authors: V
authors: Jayaraman
authors: Bernhard
authors: B
authors: Baumann
authors: Ireneusz
authors: I
authors: Grulkowski
authors: Jonathan J
authors: JJ
authors: Liu
authors: Chen D
authors: CD
authors: Lu
authors: Alex E
authors: AE
authors: Cable
authors: David
authors: D
authors: Huang
authors: Jay S
authors: JS
authors: Duker
authors: James G
authors: JG
authors: Fujimoto
mesh_terms: D000465:Algorithms; D004867:Equipment Design; D005583:Fourier Analysis; D006801:Humans; D007834:Lasers; D008027:Light; D012039:Regional Blood Flow; D012160:Retina / Q000473:pathology*; D012171:Retinal Vessels / Q000473:pathology; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*
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