title: Effects of intraduodenal injection of Lactobacillus brevis SBC8803 on autonomic neurotransmission and appetite in rodents.
abstract: Lactobacilli provide several health benefits to mammals, including humans. We previously observed that in rats, intraduodenal injection of Lactobacillus johnsonii La1 elevated efferent gastric vagal nerve activity (efferent-GVNA), while Lactobacillus paracasei ST11 suppressed efferent-GVNA, and thereby increased or decreased food intake. To determine the function of Lactobacillus brevis (SBC8803), its effect on food intake was examined by providing food containing heat-killed SBC8803 to mice. We observed that administration of SBC8803 elevated food intake. Because the afferent intestinal vagal nerve (IVN) is hypothesized to be involved in efferent-GVNA changes, we examined the effect of intraduodenal administration of heat-killed SBC8803 on efferent-GVNA and afferent-IVN activity (IVNA) in rats. In this study, we found that intraduodenal administration of heat-killed SBC8803 increased both efferent-GVNA and afferent-IVNA in rats. Moreover, IV administration of the serotonin 3 receptor antagonist granisetron eliminated the effects of SBC8803 on efferent-GVNA and afferent-IVNA. These findings suggest that heat-killed SBC8803 enhances appetite by elevating digestion and absorption abilities via changes in autonomic neurotransmission that might be mediated by the serotonin 3 receptor.
authors: ANBAS Corporation, 4-12-17 Toyosaki, Kita-ku, Osaka 531-0072, Japan. yhorii@anbas.co.jp
authors: Yuko
authors: Y
authors: Horii
authors: Yasukazu
authors: Y
authors: Nakakita
authors: Yoshiyuki
authors: Y
authors: Fujisaki
authors: Saori
authors: S
authors: Yamamoto
authors: Nanako
authors: N
authors: Itoh
authors: Koyomi
authors: K
authors: Miyazaki
authors: Hirotaka
authors: H
authors: Kaneda
authors: Katsutaka
authors: K
authors: Oishi
authors: Tatsuro
authors: T
authors: Shigyo
authors: Katsuya
authors: K
authors: Nagai
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001066:Appetite; D004386:Duodenum; D004435:Eating; D004525:Efferent Pathways / Q000187:drug effects / Q000502:physiology; D017829:Granisetron / Q000494:pharmacology; D007422:Intestines / Q000294:innervation; D052196:Levilactobacillus brevis; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology; D013270:Stomach / Q000294:innervation; D009435:Synaptic Transmission; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*
chemical_list: D017829:Granisetron; D012702:Serotonin Antagonists