title: An acid catalyzed reversible ring-opening/ring-closure reaction involving a cyano-rhodamine spirolactam.
abstract: Cyanamide was introduced into the rhodamine spirolactam framework to produce a colorless and non-fluorescent compound RBCN. It shows a reversible ring-opening/ring-closure process in response to the solution pH, which exhibits an "ON/OFF" switching in its fluorescence. Different from other rhodamine-type dyes, the ring-open form of RBCN is stable in protic solvents under neutral, near neutral and basic conditions, showing a pink color and very strong fluorescence. We also demonstrated the potential of RBCN in live cell imaging.
authors: Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA.
authors: Honglin
authors: H
authors: Li
authors: Hong
authors: H
authors: Guan
authors: Xinrui
authors: X
authors: Duan
authors: Jun
authors: J
authors: Hu
authors: Guiren
authors: G
authors: Wang
authors: Qian
authors: Q
authors: Wang
mesh_terms: D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D012235:Rhodamines / Q000138:chemical synthesis / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000143:Acids; D007769:Lactams; D012235:Rhodamines; D013141:Spiro Compounds