title: Antibody therapeutics targeting ion channels: are we there yet?
abstract: The combination of technological advances, genomic sequences and market success is catalyzing rapid development of antibody-based therapeutics. Cell surface receptors and ion channel proteins are well known drug targets, but the latter has seen less success. The availability of crystal structures, better understanding of gating biophysics and validation of physiological roles now form an excellent foundation to pursue antibody-based therapeutics targeting ion channels to treat a variety of diseases.
authors: Department of Neuroscience, High Throughput Biology Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
authors: Han
authors: H
authors: Sun
authors: Min
authors: M
authors: Li
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D007473:Ion Channels / Q000276:immunology* / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000379:methods*
chemical_list: D000906:Antibodies; D007473:Ion Channels
references: Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8328-33
references: 9653186
references: Methods Enzymol. 2012;503:269-92
references: 22230573
references: Anesthesiology. 2009 Apr;110(4):766-73
references: 19322942
references: J Biol Chem. 2004 May 14;279(20):20941-9
references: 15016832
references: Proc Natl Acad Sci U S A. 1986 Nov;83(21):8385-9
references: 2430287
references: Proc Natl Acad Sci U S A. 1982 Mar;79(5):1673-7
references: 6280195
references: Cancer Res. 2007 Aug 1;67(15):7343-9
references: 17671204
references: Ann Neurol. 1995 Nov;38(5):714-22
references: 7486862
references: Neuropharmacology. 2005 Dec;49(7):1077-87
references: 16051282
references: Nat Biotechnol. 2005 Oct;23(10):1289-93
references: 16170312
references: J Physiol. 1997 Jul 15;502 ( Pt 2):307-19
references: 9263912
references: J Biol Chem. 1988 Jan 15;263(2):613-6
references: 2447079
references: Nat Rev Immunol. 2006 May;6(5):343-57
references: 16622479
references: Brain Res. 1986 Mar 12;368(1):188-92
references: 2420414
references: Proc Natl Acad Sci U S A. 1985 Mar;82(6):1842-6
references: 2580299
references: Br J Pharmacol. 2008 Oct;155(4):567-73
references: 18604232
references: Ann Neurol. 2004 Sep;56(3):440-4
references: 15349875
references: J Biol Chem. 1987 Sep 5;262(25):11904-7
references: 2442152
references: J Membr Biol. 1992 Jan;125(1):1-11
references: 1311766
references: Sci Transl Med. 2011 May 25;3(84):84ra44
references: 21613623
references: Neurobiol Aging. 2011 Apr;32(4):698-706
references: 19446371
references: Circ Res. 1985 Sep;57(3):354-61
references: 2411443
references: Sci Transl Med. 2011 May 25;3(84):84ra43
references: 21613622
references: Trends Neurosci. 1989 Dec;12(12):496-502
references: 2480664
references: J Biol Chem. 2002 Nov 1;277(44):42157-63
references: 12196544
references: Nat Rev Immunol. 2010 May;10(5):345-52
references: 20414207
references: J Membr Biol. 1990 Jun;116(2):117-28
references: 2166163
references: FEBS Lett. 2002 Jan 16;510(3):189-95
references: 11801252
references: J Neurosci. 1995 Jan;15(1 Pt 1):274-83
references: 7823133
references: Neuropharmacology. 2008 Dec;55(7):1238-50
references: 18796308
references: J Gen Physiol. 1998 Apr;111(4):555-63
references: 9524138
references: Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2705-10
references: 18272482
references: J Pharmacol Exp Ther. 2006 Oct;319(1):192-8
references: 16844842
references: Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2653-9
references: 16861696
references: Nat Rev Immunol. 2010 May;10(5):301-16
references: 20414204
references: Mol Cancer. 2010 Jan 27;9:18
references: 20105281
references: Brain Res. 1984 Sep 17;310(1):168-73
references: 6089966
references: Brain. 2006 Jun;129(Pt 6):1570-84
references: 16613892
references: Nat Rev Cancer. 2012 Mar 22;12(4):278-87
references: 22437872
references: Am J Physiol Cell Physiol. 2006 Oct;291(4):C687-98
references: 16624990
references: J Neurosci Methods. 2005 Sep 30;147(2):88-98
references: 16111763
references: N Engl J Med. 2012 Jul 12;367(2):115-23
references: 22784115
references: Neurotherapeutics. 2007 Apr;4(2):305-14
references: 17395141
references: Circ Res. 2001 Jan 19;88(1):84-7
references: 11139478