title: Increase in interleukin-6 immediately after wheelchair basketball games in persons with spinal cord injury: preliminary report.
abstract: METHODS
  Case series.
  
  
  OBJECTIVE
  To investigate the effects of wheelchair basketball game on plasma interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and blood cell counts in persons with spinal cord injury (SCI).
  
  
  METHODS
  The 2009 Mei-shin League of Wheelchair Basketball Games held at Wakayama, Japan.
  
  
  METHODS
  Five wheelchair basketball players with SCI voluntarily participated in this study.
  
  
  METHODS
  Blood samples were taken approximately 1 h before the player warm-up for the game and immediately after the game.
  
  
  METHODS
  IL-6, TNF-α, CRP and blood cell count were measured.
  
  
  RESULTS
  Plasma IL-6 level and number of monocytes were significantly increased after the game, compared with pre-game measurements (P<0.05). No changes were observed in other measurements. There was a significant relationship between increased IL-6 levels and accumulated play duration.
  
  
  CONCLUSIONS
  The lack of change in TNF-α and CRP levels suggested that the exercise-induced rise in IL-6 was not related to exercise-induced inflammatory response. Furthermore, the associated increase in the number of monocytes did not correlate with exercise-induced IL-6 changes, negating monocytes as the source of IL-6.
authors: Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama city, Wakayama, Japan.
authors: T
authors: T
authors: Kinoshita
authors: T
authors: T
authors: Nakamura
authors: Y
authors: Y
authors: Umemoto
authors: D
authors: D
authors: Kojima
authors: T
authors: T
authors: Moriki
authors: T
authors: T
authors: Mitsui
authors: M
authors: M
authors: Goto
authors: Y
authors: Y
authors: Ishida
authors: F
authors: F
authors: Tajima
mesh_terms: D000328:Adult; D001490:Basketball / Q000502:physiology*; D002097:C-Reactive Protein / Q000032:analysis; D006233:Persons with Disabilities; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology; D013119:Spinal Cord Injuries / Q000097:blood* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014910:Wheelchairs
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein