title: Does Serum Bilirubin level on admission predict TIMI flow grade and in-hospital MACE in patients with STEMI undergoing primary PCI.
abstract: We evaluated the association of total bilirubin with post-percutaneous coronary intervention (PCI) coronary blood flow and in-hospital major adverse cardiac events (MACEs) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI. A total of 536 consecutive patients with STEMI (male 79%, mean age = 59.9 ± 12.6 years) admitted within 6 hours from symptom onset were enrolled. Patients were divided into 2 groups based on the thrombolysis in myocardial infarction (MI) flow grade. In-stent thrombosis, nonfatal MI, and in-hospital mortality were significantly higher in no-reflow group (P = .007, P = .002, and P < .001, respectively). On multivariate regression, the total bilirubin levels remained independent predictors of no-reflow (odds ratio [OR] 1.586, 95% confidence interval [CI] 1.02-2.47; P = .042) and in-hospital MACE (OR 1.399, 95% CI 1.053-1.857; P = .020). Serum bilirubin levels were independently associated with no-reflow and in-hospital MACE in patients with STEMI undergoing primary PCI.
authors: 1Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey.
authors: Turgay
authors: T
authors: Celik
authors: Mehmet G
authors: MG
authors: Kaya
authors: Mahmut
authors: M
authors: Akpek
authors: Mikail
authors: M
authors: Yarlioglues
authors: Bahadir
authors: B
authors: Sarli
authors: Ramazan
authors: R
authors: Topsakal
authors: Charles Michael
authors: CM
authors: Gibson
mesh_terms: D001663:Bilirubin / Q000097:blood*; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000209:etiology; D003955:Diagnostic Tests, Routine; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D062645:Percutaneous Coronary Intervention; D011183:Postoperative Complications; D016896:Treatment Outcome
chemical_list: D001663:Bilirubin
keywords: ST-segment elevation myocardial infarction; bilirubin; no-reflow; primary percutaneous coronary intervention