title: A three-component reaction of C,N-cyclic N'-acyl azomethine imines, isocyanides, and azide compounds: effective synthesis of 1,5-disubstituted tetrazoles with tetrahydroisoquinoline skeletons.
abstract: A multicomponent reaction of isocyanides and C,N-cyclic N'-acyl azomethine imines in the presence of TMSCl and NaN3 leads to tetrazole derivatives. These reactions proceeded cleanly to afford the corresponding 1,5-disubstituted tetrazoles containing a tetrahydroisoquinoline skeleton in high to excellent yields.
authors: Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. soeta@se.kanazawa-u.ac.jp
authors: Takahiro
authors: T
authors: Soeta
authors: Kaname
authors: K
authors: Tamura
authors: Shuhei
authors: S
authors: Fujinami
authors: Yutaka
authors: Y
authors: Ukaji
mesh_terms: D001386:Azides / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D044005:Tetrahydroisoquinolines / Q000737:chemistry*; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D001386:Azides; D001391:Azo Compounds; D003486:Cyanides; D007097:Imines; D044005:Tetrahydroisoquinolines; D013777:Tetrazoles; D013882:Thiosemicarbazones; C512188:azomethine