title: Aging-related episodic memory decline: are emotions the key?
abstract: Episodic memory refers to the recollection of personal experiences that contain information on what has happened and also where and when these events took place. Episodic memory function is extremely sensitive to cerebral aging and neurodegerative diseases. We examined episodic memory performance with a novel test in young (N = 17, age: 21-45), middle-aged (N = 16, age: 48-62) and aged but otherwise healthy participants (N = 8, age: 71-83) along with measurements of trait and state anxiety. As expected we found significantly impaired episodic memory performance in the aged group as compared to the young group. The aged group also showed impaired working memory performance as well as significantly decreased levels of trait anxiety. No significant correlation between the total episodic memory and trait or state anxiety scores was found. The present results show an age-dependent episodic memory decline along with lower trait anxiety in the aged group. Yet, it still remains to be determined whether this difference in anxiety is related to the impaired episodic memory performance in the aged group.
authors: Neurobiologie des Processus Adaptatifs, UMR 7102, Université Pierre et Marie Curie, Paris 6 Paris, France ; CNRS, UMR 7102 Paris, France ; Institut de la longévité, AP-HP Hôpital Charles Foix, Ivry-sur-Seine Paris, France.
authors: Kiyoka
authors: K
authors: Kinugawa
authors: Sophie
authors: S
authors: Schumm
authors: Monica
authors: M
authors: Pollina
authors: Marion
authors: M
authors: Depre
authors: Carolin
authors: C
authors: Jungbluth
authors: Mohamed
authors: M
authors: Doulazmi
authors: Claude
authors: C
authors: Sebban
authors: Armin
authors: A
authors: Zlomuzica
authors: Reinhard
authors: R
authors: Pietrowsky
authors: Bettina
authors: B
authors: Pause
authors: Jean
authors: J
authors: Mariani
authors: Ekrem
authors: E
authors: Dere
keywords: aging; anxiety; depression; episodic memory; working memory
references: J Neuropsychiatry Clin Neurosci. 1991 Winter;3(1):78-80
references: 7580179
references: Neurologist. 2007 May;13(3):105-17
references: 17495754
references: Neuropsychologia. 2004;42(10):1313-35
references: 15193940
references: Curr Top Behav Neurosci. 2012;10:51-66
references: 21910076
references: Neurosci Biobehav Rev. 2010 Jun;34(7):1080-91
references: 19896974
references: Hippocampus. 1998;8(3):198-204
references: 9662134
references: Neuropsychologia. 2011 Mar;49(4):663-73
references: 21262244
references: Neuropsychologia. 2010 Dec;48(14):4020-30
references: 20946907
references: Memory. 2009 Feb;17(2):208-19
references: 18608972
references: Trends Neurosci. 1998 Jul;21(7):294-9
references: 9683321
references: J Neurosci. 2006 Jan 18;26(3):916-25
references: 16421311
references: J Neurosci. 2000 Aug 15;20(16):6173-80
references: 10934267
references: Annu Rev Neurosci. 2004;27:1-28
references: 15217324
references: Neuroimage. 2002 Jun;16(2):317-30
references: 12030819
references: Memory. 2009 Feb;17(2):220-32
references: 18654927
references: Hippocampus. 2008;18(10):996-1007
references: 18548579
references: Ann N Y Acad Sci. 2003 Apr;985:273-93
references: 12724165
references: Psychol Med. 2000 May;30(3):679-91
references: 10883722
references: Psychol Aging. 2002 Jun;17(2):299-320
references: 12061414
references: Anim Cogn. 2011 Jan;14(1):95-102
references: 20661614
references: Lancet Neurol. 2007 Aug;6(8):734-46
references: 17616482
references: Psychol Aging. 2005 Mar;20(1):3-18
references: 15769210
references: Psychol Bull. 1997 May;121(3):331-54
references: 9136640
references: Arch Clin Neuropsychol. 2009 Feb;24(1):105-12
references: 19395360
references: Br J Nurs. 2008 Feb 14-27;17(3):138-45
references: 18414252
references: Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13508-14
references: 8942964
references: Annu Rev Psychol. 2002;53:1-25
references: 11752477
references: Neurobiol Learn Mem. 2005 Nov;84(3):214-21
references: 16102980
references: J Neurosci Methods. 2010 May 30;189(1):88-96
references: 20346975
references: Psychol Med. 2004 Jan;34(1):83-91
references: 14971629
references: Crit Rev Neurobiol. 2000;14(3-4):165-97
references: 12645957
references: Memory. 2004 Mar;12(2):237-47
references: 15250188
references: Neuron. 2002 Aug 15;35(4):625-41
references: 12194864
references: Trends Cogn Sci. 2012 May;16(5):292-305
references: 22542563
references: Nature. 1998 Sep 17;395(6699):272-4
references: 9751053
references: Curr Biol. 2007 Oct 23;17(20):R868-74
references: 17956742
references: Acta Psychiatr Scand. 2007 Jun;115(6):458-65
references: 17498157
references: Exp Aging Res. 2005 Oct-Dec;31(4):355-91
references: 16147458
references: Psychon Bull Rev. 2011 Dec;18(6):1113-8
references: 21912997
references: CNS Drugs. 2006;20(6):477-505
references: 16734499
references: Neurobiol Learn Mem. 2006 Mar;85(2):173-82
references: 16290193
references: Psychol Aging. 2002 Dec;17(4):677-89
references: 12507363
references: Neuropsychologia. 2011 Mar;49(4):718-33
references: 20933525
references: BMJ. 1988 Oct 8;297(6653):897-9
references: 3140969
references: Exp Aging Res. 2011 Jan;37(1):108-28
references: 21240821
references: Nat Neurosci. 2008 Jul;11(7):834-42
references: 18552840
references: Psychol Sci. 2009 Jan;20(1):74-84
references: 19152542
references: Brain Res Brain Res Protoc. 2005 Dec;16(1-3):10-9
references: 16185914
references: Learn Mem. 2012 Mar 12;19(4):146-50
references: 22411421
references: Cereb Cortex. 2006 Jul;16(7):907-15
references: 16162855
references: Behav Brain Res. 2010 Dec 31;215(2):162-71
references: 20227444
references: Stress. 2012 May;15(3):272-80
references: 22066715
references: Nature. 1996 Apr 25;380(6576):715-7
references: 8614466