title: Association study of CRP gene in systemic sclerosis in European Caucasian population.
abstract: Opsonization and apoptotic cell elements are critical in systemic lupus erythematosus (SLE) and could act through the activation of the innate immunity. C-reactive protein (CRP) belongs to opsonins, and polymorphisms of CRP gene have been shown to be associated with SLE susceptibility. Accumulating evidences show that SLE and systemic sclerosis (SSc) share some genetic susceptibility factors. To determine whether polymorphisms of CRP confer susceptibility to SSc, four SNPs (rs1130864, rs1205, rs1800947 and rs1341665), chosen using Hapmap linkage disequilibrium data and published data, were genotyped in a cohort of 651 SSc patients (569 with antinuclear antibodies, 258 with anti-centromere and 153 with anti-topoisomerase I) and 442 controls. All individuals were of French Caucasian origin. The four polymorphisms were in Hardy-Weinberg equilibrium in the control population. Allelic and genotypic frequencies for these four polymorphisms were found to be similar in SSc patients and controls. Moreover, subphenotype analyses in particular for subgroups having antinuclear antibodies did not detect any difference between SSc patients and controls. These results obtained through a large cohort of European Caucasian SSc patients do not support the implication of CRP gene in the pathogenesis of SSc.
authors: Rhumatologie A, APHP, Hôpital Cochin, Université Paris Descartes, 27 Rue du faubourg St Jacques, 75014, Paris, France, julienwipff@gmail.com.
authors: Julien
authors: J
authors: Wipff
authors: Philippe
authors: P
authors: Dieudé
authors: Jérôme
authors: J
authors: Avouac
authors: Eric
authors: E
authors: Hachulla
authors: Jean-Luc
authors: JL
authors: Cracowski
authors: Elisabeth
authors: E
authors: Diot
authors: Luc
authors: L
authors: Mouthon
authors: Jean
authors: J
authors: Sibilia
authors: Kiet
authors: K
authors: Tiev
authors: Olivier
authors: O
authors: Meyer
authors: André
authors: A
authors: Kahan
authors: Catherine
authors: C
authors: Boileau
authors: Yannick
authors: Y
authors: Allanore
mesh_terms: D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D002097:C-Reactive Protein / Q000235:genetics*; D016022:Case-Control Studies; D004264:DNA Topoisomerases, Type I / Q000276:immunology; D005060:Europe; D005260:Female; D005602:France; D020022:Genetic Predisposition to Disease / Q000208:ethnology* / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012595:Scleroderma, Systemic / Q000097:blood / Q000208:ethnology* / Q000235:genetics*; D044465:White People / Q000208:ethnology / Q000235:genetics*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000974:Antibodies, Antinuclear; C538950:anticentromere antibody; D002097:C-Reactive Protein; D004264:DNA Topoisomerases, Type I
references: Presse Med. 2008 Mar;37(3 Pt 2):444-59
references: 18242045
references: J Rheumatol. 1988 Feb;15(2):202-5
references: 3361530
references: Arthritis Rheum. 2009 Jan;60(1):225-33
references: 19116937
references: Hum Mol Genet. 2008 Apr 15;17(8):1147-55
references: 18182444
references: Arthritis Res Ther. 2003;5(2):80-93
references: 12718748
references: Rheumatology (Oxford). 2010 Feb;49(2):203-10
references: 19923204
references: Joint Bone Spine. 2010 Oct;77(5):384-9
references: 20627790
references: Arthritis Rheum. 2009 Aug;60(8):2472-9
references: 19644887
references: J Rheumatol. 2009 May;36(5):976-83
references: 19273457
references: J Am Coll Cardiol. 2007 Sep 18;50(12):1115-22
references: 17868801
references: Nat Immunol. 2004 Oct;5(10):981-6
references: 15454921
references: J Clin Immunol. 2005 Nov;25(6):582-91
references: 16380821
references: Clin Exp Rheumatol. 2007 Nov-Dec;25(6 Suppl 47):159-62
references: 18021523
references: Hum Mol Genet. 2004 Jan 1;13(1):137-47
references: 14645206
references: Autoimmun Rev. 2010 May;9(7):473-6
references: 20144911