title: Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization.
abstract: Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a lipid bilayer. Such instability can be overcome by embedding membrane proteins in detergent micelles formed from amphiphiles with carefully tuned properties. This study introduces a class of easy-to-synthesize amphiphiles, which are designated CGT (Chae's Glyco-Triton) detergents. Some of the agents are well suited for membrane protein solubilization and stabilization.
authors: Department of Bionano Engineering, Hanyang University, Ansan, 426-791, Korea. pchae@hanyang.ac.kr
authors: Pil Seok
authors: PS
authors: Chae
authors: Marc J
authors: MJ
authors: Wander
authors: Kyung Ho
authors: KH
authors: Cho
authors: Philip D
authors: PD
authors: Laible
authors: Samuel H
authors: SH
authors: Gellman
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D003902:Detergents / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry*; D008823:Micelles; D017830:Octoxynol / Q000737:chemistry*; D055550:Protein Stability; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D002241:Carbohydrates; D003902:Detergents; D008565:Membrane Proteins; D008823:Micelles; D013501:Surface-Active Agents; D017830:Octoxynol
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