title: Diagnosis and treatment of invasive fungal infections focus on liposomal amphotericin B.
abstract: Invasive fungal infections (IFIs) are responsible for significant morbidity and mortality, especially in immunocompromised patients and in those requiring admission to an intensive care unit. The epidemiology of IFI is changing, and an increment in non-Aspergillus filamentous fungi and non-Candida                 albicans species has been observed. The present paper reviews the epidemiology and diagnosis of IFIs. Regarding the treatment of IFIs, it focuses primarily on the role of liposomal amphotericin B in this setting. The main recommendations put forth by expert societies and groups are discussed.
authors: Serviço de Hematologia e Transplante de Medula, Hospital Santa Maria, Clínica Universitária de Hematolgia, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal. jlacerda@fm.ul.pt
authors: João F
authors: JF
authors: Lacerda
authors: Carlos Meneses
authors: CM
authors: Oliveira
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B
references: Intensive Care Med. 2009 Jan;35(1):55-62
references: 18972101
references: Clin Infect Dis. 2009 Mar 1;48(5):503-35
references: 19191635
references: Antimicrob Agents Chemother. 1998 Sep;42(9):2391-8
references: 9736569
references: Clin Infect Dis. 2009 Apr 15;48(8):1042-51
references: 19281327
references: Antimicrob Agents Chemother. 2005 Dec;49(12):4867-75
references: 16304147
references: J Chemother. 2002 Dec;14(6):562-7
references: 12583546
references: J Clin Microbiol. 2005 Oct;43(10):5395-6
references: 16208029
references: Clin Infect Dis. 1998 Dec;27(6):1406-12
references: 9868651
references: Clin Infect Dis. 2005 Sep 1;41(5):654-9
references: 16080087
references: Cancer. 2007 Aug 15;110(4):830-4
references: 17607669
references: Clin Infect Dis. 2008 Mar 15;46(6):886-9
references: 18260748
references: Clin Infect Dis. 2008 Oct 15;47(8):1000-6
references: 18781879
references: Am J Med. 1989 Jun;86(6 Pt 1):668-72
references: 2658574
references: Am J Med. 1982 Jan;72(1):101-11
references: 7058815
references: Curr Opin Hematol. 2008 Nov;15(6):586-93
references: 18832929
references: Clin Microbiol Infect. 2008 May;14 Suppl 4:71-83
references: 18430132
references: Clin Microbiol Infect. 2008 May;14 Suppl 4:25-36
references: 18430127
references: Clin Infect Dis. 1999 May;28(5):1071-9
references: 10452637
references: N Engl J Med. 2002 Jan 24;346(4):225-34
references: 11807146
references: Drugs. 2009;69(3):361-92
references: 19275278
references: J Antimicrob Chemother. 2006 Apr;57(4):724-31
references: 16446374
references: Lancet. 2007 May 5;369(9572):1519-1527
references: 17482982
references: Clin Infect Dis. 2000 Apr;30(4):710-8
references: 10770733
references: Infection. 2000 Jul-Aug;28(4):223-6
references: 10961528
references: Clin Microbiol Rev. 2007 Jan;20(1):133-63
references: 17223626
references: Med Mycol. 1998 Dec;36(6):437-40
references: 10206757
references: Clin Infect Dis. 2003 Nov 1;37(9):1172-7
references: 14557960
references: N Engl J Med. 2002 Aug 8;347(6):408-15
references: 12167683
references: Clin Infect Dis. 2011 Feb 15;52(4):427-31
references: 21205990
references: Intensive Care Med. 2008 Feb;34(2):292-9
references: 17909746
references: Pediatr Infect Dis J. 1998 Feb;17(2):146-8
references: 9493812
references: AIDS. 1997 Oct;11(12):1463-71
references: 9342068
references: Bone Marrow Transplant. 2009 Apr;43(7):553-61
references: 19079316
references: J Clin Microbiol. 2004 Apr;42(4):1519-27
references: 15070998
references: N Engl J Med. 2004 Sep 30;351(14):1391-402
references: 15459300
references: Clin Infect Dis. 2007 Feb 1;44(3):402-9
references: 17205448
references: Clin Infect Dis. 2008 Feb 1;46(3):327-60
references: 18177225
references: Clin Infect Dis. 2007 May 15;44(10):1329-36
references: 17443470
references: Clin Infect Dis. 2007 Nov 1;45(9):1161-70
references: 17918077
references: Clin Infect Dis. 2010 Apr 15;50(8):1101-11
references: 20218876
references: Immunol Lett. 2007 Mar 15;109(1):76-82
references: 17321603
references: Bone Marrow Transplant. 2011 May;46(5):709-18
references: 20661235
references: Mycoses. 2011 Sep;54(5):e449-55
references: 21039936
references: Clin Infect Dis. 2008 Mar 15;46(6):890-6
references: 18260751
references: Clin Infect Dis. 2004 Mar 15;38(6):913-6
references: 14999640
references: Hum Immunol. 2007 Jan;68(1):41-50
references: 17207711
references: J Antimicrob Chemother. 2008 Apr;61(4):835-7
references: 18218642
references: N Engl J Med. 1999 Mar 11;340(10):764-71
references: 10072411
references: Intensive Care Med. 2009 Feb;35(2):206-14
references: 18972100
references: J Antimicrob Chemother. 1991 Oct;28 Suppl B:73-82
references: 1778894
references: Antimicrob Agents Chemother. 2005 Sep;49(9):3640-5
references: 16127033
references: Clin Infect Dis. 2007 Oct 1;45(7):e101-4
references: 17806041
references: Antimicrob Agents Chemother. 2008 Oct;52(10):3637-41
references: 18694949
references: J Antimicrob Chemother. 2011 Jan;66 Suppl 1:i25-35
references: 21177401
references: Ann Intern Med. 2002 Jul 16;137(2):105-9
references: 12118965
references: Haematologica. 2000 Oct;85(10):1068-71
references: 11025599
references: Clin Infect Dis. 2007 May 15;44(10):1289-97
references: 17443465
references: Antimicrob Agents Chemother. 2008 Apr;52(4):1573-6
references: 18227182
references: J Clin Microbiol. 1999 May;37(5):1510-7
references: 10203514
references: Lancet. 2004 May 29;363(9423):1764-7
references: 15172774
references: Clin Infect Dis. 2008 Mar 15;46(6):878-85
references: 18260755
references: Clin Infect Dis. 2005 Sep 1;41(5):634-53
references: 16080086
references: Br J Haematol. 1998 Oct;103(1):205-12
references: 9792309
references: Clin Infect Dis. 2000 Nov;31(5):1155-63
references: 11073745
references: Clin Infect Dis. 2010 Jul 15;51(2):225-32
references: 20536366
references: Drugs. 2008;68(14):1941-62
references: 18778118
references: Antimicrob Agents Chemother. 2005 Mar;49(3):945-51
references: 15728887
references: Blood. 2003 Aug 1;102(3):827-33
references: 12689933
references: Clin Infect Dis. 2004 Aug 1;39(3):309-17
references: 15306996
references: Clin Microbiol Infect. 2009 Oct;15 Suppl 5:87-92
references: 19754765
references: Infection. 2008 Aug;36(4):296-313
references: 18642109
references: Clin Infect Dis. 2006 Apr 1;42(7):e61-5
references: 16511748
references: Clin Infect Dis. 2010 Apr 15;50(8):1091-100
references: 20218877
references: Antimicrob Agents Chemother. 2002 Jul;46(7):2273-5
references: 12069988
references: Antimicrob Agents Chemother. 2007 Mar;51(3):1126-9
references: 17194821
references: Crit Care. 2009;13(5):R159
references: 19804626
references: Antimicrob Agents Chemother. 2002 Jun;46(6):1723-7
references: 12019081
references: Clin Infect Dis. 2008 Jun 15;46(12):1813-21
references: 18462102
references: Clin Microbiol Infect. 2008 May;14 Suppl 4:46-54
references: 18430129