title: Wnt signaling in normal and malignant hematopoiesis.
abstract: One of the most remarkable characteristics of stem cells is their ability to perpetuate themselves through self-renewal while concomitantly generating differentiated cells. In the hematopoietic system, stem cells balance these mechanisms to maintain steady-state hematopoiesis for the lifetime of the organism, and to effectively regenerate the system following injury. Defects in the proper control of self-renewal and differentiation can be potentially devastating and contribute to the development of malignancies. In this review, we trace the emerging role of Wnt signaling as a critical regulator of distinct aspects of self-renewal and differentiation, its contribution to the maintenance of homeostasis and regeneration, and how the pathway can be hijacked to promote leukemia development. A better understanding of these processes could pave the way to enhancing recovery after injury and to developing better therapeutic approaches for hematologic malignancies.
authors: Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
authors: William
authors: W
authors: Lento
authors: Kendra
authors: K
authors: Congdon
authors: Carlijn
authors: C
authors: Voermans
authors: Marcie
authors: M
authors: Kritzik
authors: Tannishtha
authors: T
authors: Reya
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D060449:Wnt Signaling Pathway; D014981:Xenopus
chemical_list: D051153:Wnt Proteins
references: Genes Dev. 2011 Sep 15;25(18):1928-42
references: 21890648
references: Blood. 2004 May 1;103(9):3535-43
references: 14739224
references: Clin Cancer Res. 2010 Oct 1;16(19):4695-701
references: 20688898
references: Immunity. 2000 Jul;13(1):15-24
references: 10933391
references: Am J Physiol Cell Physiol. 2010 Aug;299(2):C422-30
references: 20664068
references: Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3322-6
references: 16492759
references: Blood. 2009 May 28;113(22):5444-55
references: 19324903
references: Mol Cell Biol. 2004 Apr;24(7):2890-904
references: 15024077
references: Development. 2011 Mar;138(6):1017-31
references: 21343360
references: Blood. 2005 Mar 15;105(6):2487-94
references: 15572594
references: Blood. 2009 Jan 15;113(3):546-54
references: 18832654
references: Vasc Cell. 2011 Dec 14;3:28
references: 22168911
references: Oncogene. 2005 Aug 11;24(34):5396-400
references: 16007226
references: Cell. 1996 Aug 9;86(3):391-9
references: 8756721
references: J Exp Med. 1991 May 1;173(5):1133-42
references: 1827138
references: Stem Cells. 2008 May;26(5):1202-10
references: 18308947
references: Nat Immunol. 2006 Oct;7(10):1037-47
references: 16951686
references: Nature. 2007 Jun 21;447(7147):1007-11
references: 17581586
references: Genes Dev. 1991 May;5(5):880-94
references: 1827423
references: Nature. 2008 Oct 30;455(7217):1205-9
references: 18806775
references: Cell Stem Cell. 2011 Oct 4;9(4):345-56
references: 21982234
references: Stem Cells Dev. 2009 Jun;18(5):759-72
references: 18800919
references: Curr Opin Hematol. 2010 Jul;17(4):308-12
references: 20473159
references: Cell. 2009 Mar 20;136(6):1136-47
references: 19303855
references: Cancer Cell. 2003 Nov;4(5):349-60
references: 14667502
references: PLoS Biol. 2010 Jan 26;8(1):e1000296
references: 20126258
references: Nat Immunol. 2009 Sep;10(9):992-9
references: 19648923
references: Stem Cells. 2011 Jan;29(1):108-18
references: 20960517
references: Blood. 2007 Jun 15;109(12):5463-72
references: 17317856
references: Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16160-5
references: 20805504
references: Nature. 2008 May 22;453(7194):529-33
references: 18463637
references: Biochem Biophys Res Commun. 2011 Sep 16;413(1):98-104
references: 21875572
references: Nat Rev Immunol. 2005 Jan;5(1):21-30
references: 15630426
references: Cancer Cell. 2010 Jul 13;18(1):74-87
references: 20609354
references: N Engl J Med. 2004 Aug 12;351(7):657-67
references: 15306667
references: J Clin Invest. 2009 Dec;119(12):3519-29
references: 19959876
references: Nature. 2003 May 22;423(6938):409-14
references: 12717450
references: J Exp Med. 2007 Dec 24;204(13):3077-84
references: 18070933
references: Mol Cell Biol. 2008 Mar;28(5):1713-23
references: 18160717
references: Eur J Immunol. 2002 Apr;32(4):967-71
references: 11920562
references: Eur J Immunol. 2001 Jan;31(1):285-93
references: 11265645
references: Blood. 2004 Aug 1;104(3):675-86
references: 15090461
references: Immunity. 2005 Dec;23(6):599-609
references: 16356858
references: Development. 2008 Oct;135(20):3447-58
references: 18799543
references: Nature. 2010 Jun 10;465(7299):793-7
references: 20535209
references: J Cell Sci. 2006 Apr 1;119(Pt 7):1283-96
references: 16522681
references: Blood. 1998 Nov 1;92(9):3189-202
references: 9787155
references: Cancer Cell. 2007 Dec;12(6):528-41
references: 18068630
references: Science. 2010 Mar 26;327(5973):1650-3
references: 20339075
references: Trends Genet. 1999 Jan;15(1):1-3
references: 10087922
references: Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3925-9
references: 19237556
references: Nat Immunol. 2003 Dec;4(12):1177-82
references: 14608382
references: Int Immunol. 2003 Dec;15(12):1485-94
references: 14645157
references: Cancer Cell. 2010 Dec 14;18(6):606-18
references: 21156284
references: Stem Cells. 2008 Nov;26(11):2991-3001
references: 18757297
references: Blood. 1997 May 15;89(10):3624-35
references: 9160667
references: Cell Stem Cell. 2009 Mar 6;4(3):248-62
references: 19265664
references: Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19836-41
references: 19901330
references: Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15436-41
references: 17881570
references: J Immunol. 1998 Oct 15;161(8):3984-91
references: 9780167
references: Nat Immunol. 2001 Aug;2(8):691-7
references: 11477404
references: Nat Immunol. 2006 Oct;7(10):1048-56
references: 16951689
references: J Cell Biol. 2003 Sep 1;162(5):899-908
references: 12952940
references: Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11464-9
references: 10500199
references: Genes Dev. 1994 Nov 15;8(22):2691-703
references: 7958926
references: J Immunol. 2006 Aug 15;177(4):2294-303
references: 16887990
references: Nature. 2011 Jun 08;474(7350):220-4
references: 21654806
references: Nat Med. 2006 Jan;12(1):89-98
references: 16341242
references: J Immunol. 2008 Sep 15;181(6):3955-64
references: 18768850