title: Different factors influence recanalisation rate after coiling in ruptured and unruptured intracranial aneurysms.
abstract: BACKGROUND
  Most studies evaluating long-term efficacy after coil embolisation of intracranial aneurysms have not differentiated between ruptured and unruptured aneurysms.
  
  
  OBJECTIVE
  The aim of this study was to analyse factors that influence recanalisation in ruptured and unruptured aneurysms.
  
  
  METHODS
  We performed a retrospective analysis of 182 (98 ruptured, 84 unruptured) aneurysms, treated with coil embolisation alone that received follow-up with digital substraction angiography (DSA).
  
  
  RESULTS
  At 6 months 26% of the aneurysms showed recanalisation. Multivariate variance analysis revealed that different factors influenced recanalisation in ruptured and unruptured aneurysms. In ruptured aneurysms patient age was a determinant, with younger patients recanalising more frequently than older ones (p = 0.016). Also, low initial packing density led to higher recanalisation rates (p = 0.015) than higher packing. In the unruptured aneurysm group these factors were not significant. Here, only a larger aneurysm volume led to higher recanalisation rates (p = 0.027).
  
  
  CONCLUSIONS
  Our data suggest that in ruptured aneurysms, high packing density is a key factor to prevent recanalisation, while in unruptured aneurysms, aneurysm volume is the main predictor for recanalisation.
authors: Acute Vascular Imaging Centre, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford OX3 9DU, UK. i.grunwald@gmx.net
authors: Iris Q
authors: IQ
authors: Grunwald
authors: Joyce S
authors: JS
authors: Balami
authors: Daniela
authors: D
authors: Weber
authors: Jessica
authors: J
authors: Mutter
authors: Anna L
authors: AL
authors: Kühn
authors: Christoph
authors: C
authors: Krick
authors: Wolfgang
authors: W
authors: Reith
authors: Panagiotis
authors: P
authors: Papanagiotou
authors: Kaveh
authors: K
authors: Shariat
mesh_terms: D017542:Aneurysm, Ruptured / Q000601:surgery*; D015901:Angiography, Digital Subtraction; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013525:Surgical Instruments; D016896:Treatment Outcome