title: Highly sensitive ammonia sensor with organic vertical nanojunctions for noninvasive detection of hepatic injury.
abstract: We successfully demonstrate the first solid-state sensor to have reliable responses to breath ammonia of rat. For thioacetamide (TAA)-induced hepatopathy rats, we observe that the proposed sensor can detect liver that undergoes acute-moderate hepatopathy with a p-value less than 0.05. The proposed sensor is an organic diode with vertical nanojunctions produced by using low-cost colloidal lithography. Its simple structure and low production cost facilitates the development of point-of-care technology. We also anticipate that the study is a starting point for investigating sophisticated breath-ammonia-related disease models.
authors: Institute of Physics, National Chiao Tung University, Hsinchu, Taiwan.
authors: Ming-Zhi
authors: MZ
authors: Dai
authors: Yi-Lo
authors: YL
authors: Lin
authors: Hung-Cheng
authors: HC
authors: Lin
authors: Hsiao-Wen
authors: HW
authors: Zan
authors: Kai-Ting
authors: KT
authors: Chang
authors: Hsin-Fei
authors: HF
authors: Meng
authors: Jiunn-Wang
authors: JW
authors: Liao
authors: May-Jywan
authors: MJ
authors: Tsai
authors: Henrich
authors: H
authors: Cheng
mesh_terms: D000641:Ammonia / Q000737:chemistry*; D000818:Animals; D001944:Breath Tests / Q000379:methods; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D049329:Nanostructures; D051381:Rats; D017207:Rats, Sprague-Dawley; D013853:Thioacetamide / Q000633:toxicity
chemical_list: D013853:Thioacetamide; D000641:Ammonia