title: Postdural puncture headache in migraineurs and nonheadache subjects: a prospective study.
abstract: OBJECTIVE
  To prospectively assess 1) the incidence and duration of postdural puncture headache (PDPH) in migraineurs and healthy subjects; 2) the associated risk factors; and 3) the risk of getting a migraine attack shortly before or after lumbar puncture (LP).
  
  
  METHODS
  As part of an extensive biochemical migraine research program, we assessed the occurrence, duration, and characteristics of PDPH in 160 migraineurs and 53 age- and sex-matched healthy controls. In addition, we evaluated potential risk factors for PDPH as well as the risk of developing a migraine attack before or after LP.
  
  
  RESULTS
  In total, 64 of 199 subjects (32.2%) developed PDPH. Young age, low body mass index, severe headache immediately after LP, and sitting sampling position, but not being a migraineur, increased the risk of PDPH (all p < 0.05). Duration of PDPH was prolonged by history of depression, sitting sampling position, high perceived stress during the LP procedure, and multiple LP efforts (all p < 0.05). Migraine attacks were less likely to occur before or shortly after LP.
  
  
  CONCLUSIONS
  Migraineurs are not at increased risk of developing PDPH. PDPH duration is similar in migraineurs and age- and sex-matched controls. LP does not trigger migraine attacks, and the stress of an upcoming LP might even have a protective effect against onset of migraine attacks.
authors: Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
authors: W P J
authors: WP
authors: van Oosterhout
authors: A A
authors: AA
authors: van der Plas
authors: E W
authors: EW
authors: van Zwet
authors: R
authors: R
authors: Zielman
authors: M D
authors: MD
authors: Ferrari
authors: G M
authors: GM
authors: Terwindt
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008881:Migraine Disorders / Q000150:complications / Q000453:epidemiology*; D051299:Post-Dural Puncture Headache / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors
references: Can J Anaesth. 1990 May;37(4 Pt 2):Sliii-Slxiii
references: 2193720
references: Anesthesiology. 1986 Dec;65(6):696-8
references: 3789447
references: Anesth Analg. 1990 Apr;70(4):389-94
references: 2316881
references: Neurology. 1996 Jul;47(1):33-7
references: 8710120
references: Nervenarzt. 1978 Jan;49(1):47-9
references: 628482
references: J Proteome Res. 2009 Dec;8(12):5511-22
references: 19845411
references: Psychoneuroendocrinology. 2007 Jun;32(5):532-8
references: 17459597
references: Headache. 1972 Jul;12(2):73-8
references: 4262477
references: Anesthesiology. 1994 Dec;81(6):1376-83
references: 7992906
references: J Headache Pain. 2007 Jun;8(3):157-66
references: 17568991
references: Reg Anesth. 1989 May-Jun;14(3):101-6
references: 2486588
references: Cephalalgia. 2008 Jan;28(1):5-8
references: 17956576
references: Neurology. 2000 Oct 10;55(7):909-14
references: 11061243
references: Cephalalgia. 2004;24 Suppl 1:9-160
references: 14979299
references: J Neurol. 1998 Sep;245(9):589-92
references: 9758296
references: J Emerg Med. 2008 Aug;35(2):149-57
references: 17976786
references: Neurologist. 2009 Jan;15(1):17-20
references: 19131853
references: Anaesthesia. 1987 Feb;42(2):202-5
references: 3826597
references: Ann Chir Gynaecol. 1984;73(3):139-42
references: 6388481
references: Br J Anaesth. 2003 Nov;91(5):718-29
references: 14570796
references: Headache. 2002 Feb;42(2):159-60
references: 12005297
references: Eur J Pediatr. 2003 Mar;162(3):117-121
references: 12655411
references: Acta Anaesthesiol Scand. 1995 Jul;39(5):605-12
references: 7572008
references: Neurology. 1992 Oct;42(10):1884-7
references: 1407567
references: Anaesthesist. 1979 Jan;28(1):5-11
references: 760592
references: Ann Emerg Med. 1993 Dec;22(12):1863-70
references: 8239110
references: Surgery. 1955 Sep;38(3):463-9
references: 13246935
references: Br J Anaesth. 1991 Dec;67(6):690-3
references: 1837469
references: Pain Med. 2009 Nov;10(8):1469-75
references: 19863745
references: J Am Med Assoc. 1956 Jun 16;161(7):586-91
references: 13318967
references: J Neurol Neurosurg Psychiatry. 1996 Jun;60(6):681-3
references: 8648338
references: Headache. 2002 May;42(5):356-8
references: 12047336
references: Int Anesthesiol Clin. 1986 Winter;24(4):231-55
references: 3793253
references: J Am Med Assoc. 1951 Nov 17;147(12):1118-21
references: 14873634
references: Cephalalgia. 1989 Jun;9(2):99-106
references: 2743417
references: Lancet. 1981 Nov 21;2(8256):1133-5
references: 6118577
references: Pain. 1987 Sep;30(3):293-301
references: 3313201
references: Anesth Analg. 1990 May;70(5):517-22
references: 2331068
references: Anaesthesist. 1997 Oct;46(10):860-6
references: 9424969
references: Headache. 1995 Jan;35(1):25-8
references: 7532633