title: [Systemic sclerosis. Part 1: searching for genetic determinants].
abstract: Familial aggregation of systemic sclerosis observed in the 1970 of twenty century, the presence of karyotype instability and chromosomal mosaicism and positive associations of certain polymorphisms of genes located in specific regions of the human genome may indicate the important contribution of genetic factors in the development and progression of the disease. The purpose of this paper is to present data on genetic changes found in scleroderma. Despite the enormous progress of research it is not yet clear, which disturbances in a specific way determine onset and development of the disease and which are non-specific forms of molecular abnormalities also present in other diseases with similar clinical symptoms.
authors: Zakład Genetyki Klinicznej, Uniwersytet Medyczny w Białymstoku, ul. Waszyngtona 13, 15-276 Białystok. genetyka@umb.edu.pl
authors: Alina Teresa
authors: AT
authors: Midro
authors: Barbara
authors: B
authors: Panasiuk
authors: Justyna
authors: J
authors: Fryc
authors: Beata
authors: B
authors: Stasiewicz-Jarocka
authors: Stanisław
authors: S
authors: Sierakowski
mesh_terms: D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D006801:Humans; D009030:Mosaicism; D011110:Polymorphism, Genetic; D012595:Scleroderma, Systemic / Q000235:genetics*