title: Effects of infection by larvae of Angiostrongylus cantonensis (Nematoda, Metastrongylidae) on the lipid metabolism of the experimental intermediate host Biomphalaria glabrata (Mollusca: Gastropoda).
abstract: Experimental infection of Biomphalaria glabrata by Angiostrongylus cantonensis induces significant changes in the concentrations of triacylglycerol and cholesterol in the hemolymph and of neutral lipids in the digestive gonad-gland (DGG) complex of the host snail. In this study, snails were dissected after 1, 2, and 3 weeks of infection to collect the hemolymph and DGG and to measure the levels of cholesterol and triacylglycerol in the hemolymph and neutral lipid fractions in the tissues. The results show that infection by this nematode resulted in a significant decrease in the concentrations of both cholesterol and triacylglycerol in the hemolymph of B. glabrata during the parasite's initial ontogenic development period. This reduction indicates the possible use of these molecules by both parasite and host not only as energy substrates but also as structural factors required during development of the parasite's larval stages. In parallel, changes in the neutral lipid profile in the DGG and lipase activity of the infected snails were observed, indicating the importance of these molecules for successful infection.
authors: Departamento de Ciências Fisiológicas, Instituto de Biologia, Universidade Federal Rural do Rio de Janeiro (UFRuralRJ), Seropédica, Rio de Janeiro, Brazil.
authors: Vinícius Menezes
authors: VM
authors: Tunholi-Alves
authors: Victor Menezes
authors: VM
authors: Tunholi
authors: Patrícia
authors: P
authors: Gôlo
authors: Mariana
authors: M
authors: Lima
authors: Juberlan
authors: J
authors: Garcia
authors: Arnaldo Maldonado
authors: AM
authors: Júnior
authors: Emerson Guedes
authors: EG
authors: Pontes
authors: Vânia Rita Elias Pinheiro
authors: VR
authors: Bittencourt
authors: Jairo
authors: J
authors: Pinheiro
mesh_terms: D017185:Angiostrongylus cantonensis / Q000254:growth & development / Q000472:pathogenicity*; D000818:Animals; D001700:Biomphalaria / Q000378:metabolism* / Q000469:parasitology*; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism; D006458:Hemolymph / Q000737:chemistry / Q000378:metabolism; D006790:Host-Parasite Interactions; D007814:Larva / Q000254:growth & development / Q000472:pathogenicity; D050356:Lipid Metabolism; D014280:Triglycerides / Q000032:analysis / Q000378:metabolism
chemical_list: D014280:Triglycerides; D002784:Cholesterol
references: Exp Parasitol. 2012 Jun;131(2):143-7
references: 22429660
references: Mem Inst Oswaldo Cruz. 1989 Oct-Dec;84(4):563-5
references: 2487451
references: Anal Biochem. 1978 Jun 15;87(1):206-10
references: 98070
references: Int J Parasitol. 1989 May;19(3):353-4
references: 2759775
references: Lancet Infect Dis. 2008 Oct;8(10):621-30
references: 18922484
references: J Invertebr Pathol. 1985 Mar;45(2):152-7
references: 3981029
references: J Helminthol. 2011 Dec;85(4):395-400
references: 21106133
references: Bull Environ Contam Toxicol. 2002 Apr;68(4):606-11
references: 12069068
references: J Parasitol. 1975 Oct;61(5):906-9
references: 1185433
references: J Nematol. 2003 Jun;35(2):146-56
references: 19265989
references: Exp Parasitol. 2011 Jul;128(3):212-6
references: 21439956
references: Can J Biochem Physiol. 1959 Aug;37(8):911-7
references: 13671378
references: J Invertebr Pathol. 2011 Nov;108(3):220-3
references: 21925506
references: Lipids. 1994 Dec;29(12):869-75
references: 7854013
references: Acta Trop. 2010 Sep;115(3):194-9
references: 20083081
references: Parasitol Res. 2006 Sep;99(4):414-8
references: 16583202
references: Parasitol Res. 1998 May;84(5):369-73
references: 9610633
references: C R Acad Hebd Seances Acad Sci D. 1969 Jan 20;268(3):612-5
references: 4977787
references: J Biochem Mol Biol. 2003 Jul 31;36(4):417-20
references: 12895302
references: J Parasitol. 1970 Oct;56(5):1004-8
references: 5504522
references: Braz J Biol. 2010 Feb;70(1):129-34
references: 20231969