title: Effects of ultra-early stage hyperbaric oxygenation on the hind limb bone mineral density in rats after complete spinal cord transection.
abstract: OBJECTIVE
  To study the effects of ultra-early stage hyperbaric oxygenation on the hind limb bone mineral density in rats after complete spinal cord transection.
  
  
  METHODS
  55 SD rats were randomly assigned into three groups: sham-operated group (Sham); complete spinal cord transection. (CSCT) group; and hyperbaric oxygenation (HBO2) group. Three hours after surgery, the HBO2 group started receiving hyperbaric oxygen therapy. Bone mineral density (BMD) of total femur, total tibia and their subregions in vitro was measured with dual-energy X-ray absorptiometry (DEXA).
  
  
  RESULTS
  After the six-week treatment, BMD of total femur, BMD in regions1-2 at the distal femur, BMD in regions 6-7 at the proximal femur and BMD in regions 1-2 at the proximal tibia in vitro were markedly decreased in CSCT group at six weeks post-operation compared with that in the sham-operated group (p < 0.05-0.01). Also, in the HBO2 group, BMD value of total femur in vitro was significantly higher than that in CSCT group (p < 0.05).
  
  
  CONCLUSIONS
  Ultra-early stage hyperbaric oxygenation alleviates the hind limb bone loss in femur bone in rats following complete spinal cord transection.
authors: Department of Rehabilitation, Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, PR China. liumin22626@126.com
authors: Min
authors: M
authors: Liu
authors: Xiyu
authors: X
authors: Wu
authors: Min
authors: M
authors: Tong
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D005269:Femur / Q000502:physiology*; D006614:Hindlimb; D006931:Hyperbaric Oxygenation / Q000379:methods*; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000150:complications* / Q000503:physiopathology; D013977:Tibia / Q000502:physiology*; D013997:Time Factors