title: Alzheimer disease: Aβ-independent processes-rethinking preclinical AD.
abstract: The amyloid cascade hypothesis, which posits that amyloid-β accumulation is the key event in Alzheimer disease neurodegeneration, has dominated the field for 20 years. Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-β, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies.
authors: INSERM, U1077, CHU Avenue de la Côte de Nacre, CS 30001, 14033 Caen Cedex 9, Caen, France. chetelat@cyceron.fr
authors: Gaël
authors: G
authors: Chételat
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000686:Amyloidosis / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D001930:Brain Injuries / Q000209:etiology / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D006801:Humans
chemical_list: D016229:Amyloid beta-Peptides
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