title: Childhood obesity and asthma control in the GALA II and SAGE II studies.
abstract: BACKGROUND
  Obesity is associated with increased asthma morbidity, lower drug responsiveness to inhaled corticosteroids, and worse asthma control. However, most prior investigations on obesity and asthma control have not focused on pediatric populations, considered environmental exposures, or included minority children.
  
  
  OBJECTIVE
  To examine the association between body mass index categories and asthma control among boys and girls; and whether these associations are modified by age and race/ethnicity.
  
  
  METHODS
  Children and adolescents ages 8-19 years (n = 2,174) with asthma were recruited from the Genes-environments and Admixture in Latino Americans (GALA II) Study and the Study of African Americans, Asthma, Genes, and Environments (SAGE II). Ordinal logistic regression was used to estimate odds ratios (OR) and their confidence intervals (95% CI) for worse asthma control.
  
  
  RESULTS
  In adjusted analyses, boys who were obese had a 33% greater chance of having worse asthma control than their normal-weight counterparts (OR, 1.33; 95% CI, 1.04-1.71). However, for girls this association varied with race and ethnicity (P interaction = 0.008). When compared with their normal-weight counterparts, obese African American girls (OR, 0.65; 95% CI, 0.41-1.05) were more likely to have better controlled asthma, whereas Mexican American girls had a 1.91 (95% CI, 1.12-3.28) greater odds of worse asthma control.
  
  
  CONCLUSIONS
  Worse asthma control is uniformly associated with increased body mass index in boys. Among girls, the direction of this association varied with race/ethnicity.
authors: Department of Health Sciences, Graduate Program in Public Health, Lehman College, City University of New York, Bronx, NY, USA. luisa.borrell@lehman.cuny.edu
authors: Luisa N
authors: LN
authors: Borrell
authors: Elizabeth A
authors: EA
authors: Nguyen
authors: Lindsey A
authors: LA
authors: Roth
authors: Sam S
authors: SS
authors: Oh
authors: Haig
authors: H
authors: Tcheurekdjian
authors: Saunak
authors: S
authors: Sen
authors: Adam
authors: A
authors: Davis
authors: Harold J
authors: HJ
authors: Farber
authors: Pedro C
authors: PC
authors: Avila
authors: Emerita
authors: E
authors: Brigino-Buenaventura
authors: Michael A
authors: MA
authors: Lenoir
authors: Fred
authors: F
authors: Lurmann
authors: Kelley
authors: K
authors: Meade
authors: Denise
authors: D
authors: Serebrisky
authors: William
authors: W
authors: Rodriguez-Cintron
authors: Rajesh
authors: R
authors: Kumar
authors: Jose R
authors: JR
authors: Rodriguez-Santana
authors: Shannon M
authors: SM
authors: Thyne
authors: Esteban G
authors: EG
authors: Burchard
mesh_terms: D000293:Adolescent; D001741:Black or African American; D000367:Age Factors; D001249:Asthma / Q000150:complications* / Q000208:ethnology; D015992:Body Mass Index; D002648:Child; D018450:Disease Progression; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D016015:Logistic Models; D008297:Male; D009765:Obesity / Q000150:complications* / Q000208:ethnology; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects / Q000706:statistics & numerical data
chemical_list: D014028:Tobacco Smoke Pollution
references: Mol Cell Endocrinol. 2006 Jul 25;254-255:13-21
references: 16759793
references: J Community Health. 2011 Feb;36(1):94-110
references: 20549318
references: Pediatrics. 2000 Dec;106(6):1436-41
references: 11099600
references: J Allergy Clin Immunol. 2010 Mar;125(3):584-92
references: 20226295
references: Chest. 2011 Sep;140(3):659-666
references: 21415135
references: Int J Obes (Lond). 2007 Apr;31(4):578-83
references: 17384659
references: Adv Data. 2000 Jun 8;(314):1-27
references: 11183293
references: Annu Rev Pathol. 2007;2:31-56
references: 18039092
references: J Allergy Clin Immunol. 2012 Jun;129(6):1478-83.e7
references: 22552109
references: Allergy. 2007 Oct;62(10):1205-13
references: 17845592
references: Respirology. 2012 Apr;17(3):412-21
references: 21992497
references: J Allergy Clin Immunol. 2011 Mar;127(3):741-9
references: 21377042
references: J Asthma. 2005 May;42(4):265-71
references: 16032935
references: J Clin Endocrinol Metab. 2004 Jun;89(6):2548-56
references: 15181022
references: Allergy Asthma Immunol Res. 2012 Mar;4(2):98-103
references: 22379605
references: Obes Rev. 2004 Nov;5(4):197-216
references: 15458395
references: Metab Syndr Relat Disord. 2012 Apr;10(2):143-51
references: 22283633
references: Metabolism. 2012 Sep;61(9):1261-9
references: 22444780
references: J Pediatr. 1998 Feb;132(2):204-10
references: 9506629
references: J Allergy Clin Immunol. 2011 Nov;128(5):964-9
references: 21820711
references: Am J Dis Child. 1991 Mar;145(3):259-63
references: 1750869
references: J Allergy Clin Immunol. 2010 Mar;125(3):769-70; author reply 770
references: 20226309
references: J Allergy Clin Immunol. 2008 Oct;122(4):754-759.e1
references: 19014767
references: Pediatrics. 2005 May;115(5):1254-60
references: 15867032
references: Nat Immunol. 2005 Jun;6(6):537-9
references: 15908930
references: J Asthma. 2010 Apr;47(3):263-8
references: 20210611
references: Am J Epidemiol. 2011 Jan 1;173(1):64-70
references: 21036953
references: Pediatrics. 2009 Mar;123 Suppl 3:S131-45
references: 19221156
references: Pediatr Pulmonol. 2009 May;44(5):472-9
references: 19360851
references: Am J Respir Crit Care Med. 2001 May;163(6):1344-9
references: 11371399
references: Respir Med. 2006 Apr;100(4):648-57
references: 16159709
references: C R Biol. 2006 Aug;329(8):570-7; discussion 653-5
references: 16860275
references: Clin Exp Allergy. 2007 Apr;37(4):476-84
references: 17430342
references: JAMA. 2012 Feb 1;307(5):483-90
references: 22253364
references: Am J Respir Crit Care Med. 2011 Jan 1;183(1):8-14
references: 20732985
references: Am J Respir Crit Care Med. 2011 Feb 15;183(4):441-8
references: 20851922
references: J Asthma. 2011 Mar;48(2):171-6
references: 21275851
references: Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120
references: 742764
references: Allergy. 1981 Nov;36(8):537-47
references: 7337200