title: Association of a serotonin transporter gene polymorphism (5-HTTLPR) and stressful life events with postpartum depressive symptoms: a population-based study.
abstract: We conducted a cross-sectional study nested within a cohort study with 276 postpartum women to evaluate the role of a serotonin transporter gene polymorphism (5-HTTLPR) and the stressful life events (SLE) on the risk of postpartum depression (PPD) symptoms in a community sample. Participants were assessed between 45 and 90 days after delivery with the Edinburgh Postnatal Depression Scale (EPDS) and the Mini International Neuropsychiatric Interview (MINI). Data regarding socio-demographic variables, alcohol consumption, tobacco smoking and SLE occurring during pregnancy, were also collected. In the adjusted analysis, the women carrying the long (L) allele (LL) who experienced SLE showed higher prevalence ratios (PR) for PPD symptoms (EPDS ≥13) than those with two copies of the short (S) allele (SL) (PR = 9.91; 95% confidence interval: 1.70-57.87). In contrast, a trend of association was found between prior history of major depressive disorder (MDD) and the S allele carrier status (p = 0.07). No association was found between the formal diagnosis of current MDD and the 5-HTTLPR genotypes. In line with previous reports, we find in this sample that the L allele carrier status was associated with a heighten risk of depressive symptoms in postpartum when SLE were experienced during pregnancy.
authors: Postgraduate Program inHealth and Behavior, Universidade Católica de Pelotas, Pelotas, Brazil. ricardop@terra.com.br
authors: Ricardo Tavares
authors: RT
authors: Pinheiro
authors: Fábio Monteiro da Cunha
authors: FM
authors: Coelho
authors: Ricardo Azevedo da
authors: RA
authors: Silva
authors: Karen Amaral Tavares
authors: KA
authors: Pinheiro
authors: Jean Pierre
authors: JP
authors: Oses
authors: Luciana de Ávila
authors: Lde Á
authors: Quevedo
authors: Luciano Dias de Mattos
authors: LD
authors: Souza
authors: Karen
authors: K
authors: Jansen
authors: Josi Maria
authors: JM
authors: Zimmermann Peruzatto
authors: Gisele Gus
authors: GG
authors: Manfro
authors: Márcia
authors: M
authors: Giovenardi
authors: Silvana
authors: S
authors: Almeida
authors: Aldo Bolten
authors: AB
authors: Lucion
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000483:Alleles; D003430:Cross-Sectional Studies; D019052:Depression, Postpartum / Q000235:genetics* / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012907:Smoking; D013315:Stress, Psychological / Q000235:genetics* / Q000523:psychology
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins