title: Pharmaco-miR: linking microRNAs and drug effects.
abstract: MicroRNAs (miRNAs) are short regulatory RNAs that down-regulate gene expression. They are essential for cell homeostasis and active in many disease states. A major discovery is the ability of miRNAs to determine the efficacy of drugs, which has given rise to the field of 'miRNA pharmacogenomics' through 'Pharmaco-miRs'. miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. These interactions can be described as triplet sets consisting of a miRNA, a target gene and a drug associated with the gene. We have developed a web server which links miRNA expression and drug function by combining data on miRNA targeting and protein-drug interactions. miRNA targeting information derive from both experimental data and computational predictions, and protein-drug interactions are annotated by the Pharmacogenomics Knowledge base (PharmGKB). Pharmaco-miR's input consists of miRNAs, genes and/or drug names and the output consists of miRNA pharmacogenomic sets or a list of unique associated miRNAs, genes and drugs. We have furthermore built a database, named Pharmaco-miR Verified Sets (VerSe), which contains miRNA pharmacogenomic data manually curated from the literature, can be searched and downloaded via Pharmaco-miR and informs on trends and generalities published in the field. Overall, we present examples of how Pharmaco-miR provides possible explanations for previously published observations, including how the cisplatin and 5-fluorouracil resistance induced by miR-148a may be caused by miR-148a targeting of the gene KIT. The information is available at www.Pharmaco-miR.org.
authors: Jakob Lewin
authors: JL
authors: Rukov
authors: Roni
authors: R
authors: Wilentzik
authors: Ishai
authors: I
authors: Jaffe
authors: Jeppe
authors: J
authors: Vinther
authors: Noam
authors: N
authors: Shomron
mesh_terms: D030541:Databases, Genetic; D015536:Down-Regulation; D035683:MicroRNAs / Q000235:genetics*; D010597:Pharmacogenetics
chemical_list: D035683:MicroRNAs
keywords: Pharmaco-miR; database; miRNA pharmacogenomic set; microRNAs; pharmacogenomics; web server
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