title: The battle with the host over microbial size.
abstract: An eponymous feature of microbes is their small size, and size affects their pathogenesis. The recognition of microbes by host factors, for example, is often dependent on the density and number of molecular interactions occurring over a limited surface area. As a consequence, certain antimicrobial substances, such as complement, appear to target particles with a larger surface area more effectively. Although microbes may inhibit these antimicrobial activities by minimizing their effective size, the host uses defenses such as agglutination by immunoglobulin to counteract this microbial evasion strategy. Some successful pathogens in turn are able to prevent immune mediated clearance by expressing virulence factors that block agglutination. Thus, microbial size is one of the battlegrounds between microbial survival and host defense.
authors: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States. weiser@mail.med.upenn.edu
authors: Jeffrey N
authors: JN
authors: Weiser
mesh_terms: D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions; D057131:Immune Evasion; D007113:Immunity, Innate; D014774:Virulence; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D037521:Virulence Factors
references: Science. 2012 Jul 27;337(6093):477-81
references: 22722251
references: J Antimicrob Chemother. 1987 Dec;20(6):857-69
references: 3326873
references: J Exp Med. 1915 Oct 1;22(4):457-64
references: 19867929
references: Microbes Infect. 2011 May;13(5):426-37
references: 21182979
references: Immunology. 1983 Feb;48(2):351-9
references: 6337090
references: Clin Microbiol Rev. 2010 Oct;23(4):740-80
references: 20930072
references: Cell Host Microbe. 2011 Nov 17;10(5):486-96
references: 22100164
references: Infect Immun. 2012 Oct;80(10):3454-9
references: 22825449
references: Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Feb;259(1):104-17
references: 3923732
references: PLoS Pathog. 2010 Jun 17;6(6):e1000953
references: 20585559
references: APMIS. 1996 May;104(5):321-38
references: 8703438
references: Microb Pathog. 1993 Nov;15(5):377-88
references: 8015418
references: J Innate Immun. 2010;2(6):576-86
references: 20829609
references: Curr Opin Allergy Clin Immunol. 2003 Dec;3(6):451-9
references: 14612669
references: PLoS Pathog. 2010 Jun 17;6(6):e1000945
references: 20585557
references: Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1333-8
references: 14739341
references: J Exp Med. 1915 Oct 1;22(4):484-91
references: 19867932
references: Cell. 2010 May 28;141(5):822-33
references: 20510929
references: Nat Med. 2007 Aug;13(8):981-5
references: 17632528
references: Immunobiology. 1981;159(4-5):349-65
references: 7026419
references: J Exp Med. 1916 Jul 1;24(1):49-68
references: 19868028
references: Microbiology (Reading). 2005 Feb;151(Pt 2):373-383
references: 15699188
references: Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1679-84
references: 15668390
references: Curr Biol. 2011 May 10;21(9):R297-8
references: 21549944
references: Trends Immunol. 2009 Nov;30(11):513-21
references: 19699684
references: Nat Rev Microbiol. 2008 Feb;6(2):162-8
references: 18157153
references: J Immunol. 2012 Apr 1;188(7):3522-31
references: 22345666
references: Mol Microbiol. 2006 Jul;61(2):526-43
references: 16776657
references: Exp Cell Res. 1998 Jul 10;242(1):265-73
references: 9665824
references: Microbiol Mol Biol Rev. 2006 Sep;70(3):660-703
references: 16959965