title: Association of gray matter atrophy with age, β-amyloid, and cognition in aging.
abstract: Both cognitive aging and β-amyloid (Aβ) deposition, a pathological hallmark of Alzheimer's disease, are associated with structural and cognitive changes in cognitively normal older people. To examine independent effects of age and Aβ deposition on cognition and brain structure in aging, 83 cognitively normal older adults underwent structural magnetic resonance imaging scans and neuropsychological tests and were classified as negative (PIB-) or positive (PIB+) for Aβ deposition using the radiotracer Pittsburgh compound B (PIB). Weighted composite discriminant scores represented subjects' cognition. Older adults showed age-related gray matter (GM) atrophy across the whole brain regardless of Aβ deposition. Amyloid burden within PIB+ subjects, however, was associated with GM atrophy in the frontal, parietal, and temporal cortices. Associations between cognition and volume in PIB- subjects were primarily seen throughout frontal regions and the striatum, while, in PIB+ subjects, these associations were seen in orbital-frontal and hippocampal regions. Furthermore, in PIB- subjects, cognition was related to putaminal volume, but not to hippocampus, while, in PIB+ subjects, cognition was related to hippocampal volume, but not to putamen. These findings highlight differential age and Aβ effects on brain structure, indicating effects of age and Aβ that operate somewhat independently to affect frontostriatal and medial temporal brain systems.
authors: Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA and.
authors: Hwamee
authors: H
authors: Oh
authors: Cindee
authors: C
authors: Madison
authors: Sylvia
authors: S
authors: Villeneuve
authors: Candace
authors: C
authors: Markley
authors: William J
authors: WJ
authors: Jagust
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology* / Q000523:psychology; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology* / Q000523:psychology; D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4 / Q000235:genetics; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D003071:Cognition; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D009929:Organ Size; D058225:Plaque, Amyloid / Q000473:pathology*; D025341:Principal Component Analysis; D012044:Regression Analysis
chemical_list: D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4
keywords: Pittsburgh compound B-positron emission tomography; aging; amyloid; cognition; structure
references: AJNR Am J Neuroradiol. 2003 Oct;24(9):1849-56
references: 14561615
references: Neurobiol Aging. 2012 Dec;33(12):2746-55
references: 22429886
references: Psychiatry Res. 1993 Jun;50(2):121-39
references: 8378488
references: J Int Neuropsychol Soc. 2000 Jan;6(1):52-61
references: 10761367
references: Cereb Cortex. 2007 Jun;17(6):1274-82
references: 16857855
references: Brain. 2009 May;132(Pt 5):1355-65
references: 19339253
references: Arch Neurol. 2009 Dec;66(12):1476-81
references: 20008651
references: Neuroimage. 2012 Jan 16;59(2):1152-60
references: 21884802
references: J Cereb Blood Flow Metab. 2005 Nov;25(11):1528-47
references: 15944649
references: Neuroimage. 2006 Feb 1;29(3):984-94
references: 16176876
references: Brain. 2011 Mar;134(Pt 3):798-807
references: 21310725
references: Neuroimage. 2002 Apr;15(4):870-8
references: 11906227
references: Ann Neurol. 2006 Jul;60(1):145-7
references: 16802294
references: Cereb Cortex. 1997 Apr-May;7(3):268-82
references: 9143446
references: Curr Opin Neurobiol. 2000 Apr;10(2):224-31
references: 10753795
references: J Neurosci. 2011 Dec 7;31(49):17941-54
references: 22159109
references: Neuroimage. 2011 Feb 1;54(3):1887-95
references: 20965254
references: Cereb Cortex. 2002 May;12(5):494-505
references: 11950767
references: Brain. 2008 Mar;131(Pt 3):665-80
references: 18263627
references: J Med Chem. 2003 Jun 19;46(13):2740-54
references: 12801237
references: Neurology. 2010 Jan 12;74(2):121-7
references: 20065247
references: Neuropsychologia. 2003;41(14):1929-41
references: 14572526
references: Ann Neurol. 2010 Mar;67(3):317-24
references: 20373343
references: Neurobiol Aging. 2005 Apr;26(4):491-510
references: 15653178
references: Brain. 2009 May;132(Pt 5):1310-23
references: 19042931
references: Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18760-5
references: 18003904
references: J Cereb Blood Flow Metab. 1996 Sep;16(5):834-40
references: 8784228
references: Neuron. 2004 Sep 30;44(1):195-208
references: 15450170
references: Lancet. 1989 Sep 16;2(8664):672-3
references: 2570916
references: Neuroimage. 2001 Jul;14(1 Pt 1):21-36
references: 11525331
references: Brain Pathol. 1991 Apr;1(3):213-6
references: 1669710
references: Brain. 1991 Oct;114 ( Pt 5):2283-301
references: 1933245
references: Brain. 2010 Nov;133(11):3349-58
references: 20739349
references: Neurology. 2007 May 8;68(19):1603-6
references: 17485647
references: Alzheimer Dis Assoc Disord. 2004 Oct-Dec;18(4):190-5
references: 15592129
references: Neuropsychologia. 2010 Dec;48(14):4020-30
references: 20946907
references: Cereb Cortex. 2009 Sep;19(9):2001-12
references: 19150922
references: Cereb Cortex. 2010 Sep;20(9):2069-79
references: 20051356
references: Ann Neurol. 2011 Jun;69(6):1032-42
references: 21437929
references: Cereb Cortex. 2004 Jul;14(7):721-30
references: 15054051
references: Annu Rev Neurosci. 1986;9:357-81
references: 3085570
references: Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2018-22
references: 19164761
references: Brain. 2011 Apr;134(Pt 4):1077-88
references: 21429865
references: Cereb Cortex. 2009 Mar;19(3):497-510
references: 18632739
references: Neurology. 2004 Jul 27;63(2):246-53
references: 15277616