title: Synthesis of oligo(lactose)-based thiols and their self-assembly onto gold surfaces.
abstract: The ability to produce monomolecular coatings with well-defined structural and functional properties is of key importance in biosensing, drug delivery, and many recently developed applications of nanotechnology. Organic chemistry has proven to be a powerful tool to achieve this in many research areas. Herein, we present the synthesis of three oligo(lactosides) glycosylated in a (1→3) manner, and which are further functionalized with amide-linked short alkanethiol spacers. The oligosaccharides (di-, tetra-, and hexasaccharide) originate from the inexpensive and readily available lactose disaccharide. These thiolated derivatives were immobilized onto gold surfaces, and the thus formed self-assembled monolayers (SAMs) on planar gold were characterized by wettability, ellipsometry and infrared reflection-absorption spectroscopy. Further, the ability of these SAMs to stabilize gold nanoparticles in saline solutions was also demonstrated, indicating that the oligosaccharides may be used as stabilizing agents in gold nanoparticle-based assays.
authors: Division of Chemistry, IFM, Linköping University, Linköping, Sweden. timfy@ifm.liu.se
authors: Timmy
authors: T
authors: Fyrner
authors: Thomas
authors: T
authors: Ederth
authors: Daniel
authors: D
authors: Aili
authors: Bo
authors: B
authors: Liedberg
authors: Peter
authors: P
authors: Konradsson
mesh_terms: D006046:Gold / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis*; D013499:Surface Properties; D017155:Wettability
chemical_list: D009844:Oligosaccharides; D013438:Sulfhydryl Compounds; D006046:Gold; D007785:Lactose