title: Pilot study on efficacy of reduced cathartic bowel preparation with polyethylene glycol and bisacodyl.
abstract: OBJECTIVE
  To evaluate the efficacy of reduced cathartic bowel preparation with 2 L polyethylene glycol (PEG)-4000 electrolyte solution and 10 mg bisacodyl enteric-coated tablets for computed tomographic colonography (CTC).
  
  
  METHODS
  Sixty subjects who gave informed consent were randomly assigned to study group A, study group B or the control group. On the day prior to CTC, subjects in study group A were given 20 mL 40% wt/vol barium sulfate suspension before 3 mealtimes, 60 mL 60% diatrizoate meglumine diluted in 250 mL water after supper, and 10 mg bisacodyl enteric-coated tablets 1 h before oral administration of 2 L PEG-4000 electrolyte solution. Subjects in study group B were treated identically to those in study group A, with the exception of bisacodyl which was given 1 h after oral PEG-4000. Subjects in the control group were managed using the same strategy as the subjects in study group A, but without administration of bisacodyl. Residual stool and fluid scores, the attenuation value of residual fluid, and discomfort during bowel preparation in the three groups were analyzed statistically.
  
  
  RESULTS
  The mean scores for residual stool and fluid in study group A were lower than those in study group B, but the differences were not statistically significant. Subjects in study group A showed greater stool and fluid cleansing ability than the subjects in study group B. The mean scores for residual stool and fluid in study groups A and B were lower than those in the control group, and were significantly different. There was no significant difference in the mean attenuation value of residual fluid between study group A, study group B and the control group. The total discomfort index during bowel preparation was 46, 45 and 45 in the three groups, respectively, with no significant difference.
  
  
  CONCLUSIONS
  Administration of 10 mg bisacodyl enteric-coated tablets prior to or after oral administration of 2 L PEG-4000 electrolyte solution enhances stool and fluid cleansing ability, and has no impact on the attenuation value of residual fluid or the discomfort index. The former is an excellent alternative for CTC colorectum cleansing.
authors: Department of Radiology, the Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, Guangdong Province, China.
authors: Zhi-Yuan
authors: ZY
authors: Chen
authors: He-Song
authors: HS
authors: Shen
authors: Ming-Yue
authors: MY
authors: Luo
authors: Chai-Jie
authors: CJ
authors: Duan
authors: Wen-Li
authors: WL
authors: Cai
authors: Hong-Bing
authors: HB
authors: Lu
authors: Guo-Peng
authors: GP
authors: Zhang
authors: Yang
authors: Y
authors: Liu
authors: Jerome Z
authors: JZ
authors: Liang
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001726:Bisacodyl / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002681:China; D023881:Colonography, Computed Tomographic; D003672:Defecation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D010865:Pilot Projects; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013608:Tablets, Enteric-Coated; D007507:Therapeutic Irrigation / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002400:Cathartics; D013608:Tablets, Enteric-Coated; D001726:Bisacodyl; D011092:Polyethylene Glycols
keywords: Bisacodyl; Colorectal cancer; Computed tomographic colonography; Polyethylene glycol; Screening
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