title: IL-17A in human respiratory diseases: innate or adaptive immunity? Clinical implications.
abstract: Since the discovery of IL-17 in 1995 as a T-cell cytokine, inducing IL-6 and IL-8 production by fibroblasts, and the report of a separate T-cell lineage producing IL-17(A), called Th17 cells, in 2005, the role of IL-17 has been studied in several inflammatory diseases. By inducing IL-8 production and subsequent neutrophil attraction towards the site of inflammation, IL-17A can link adaptive and innate immune responses. More specifically, its role in respiratory diseases has intensively been investigated. We here review its role in human respiratory diseases and try to unravel the question whether IL-17A only provides a link between the adaptive and innate respiratory immunity or whether this cytokine might also be locally produced by innate immune cells. We furthermore briefly discuss the possibility to reduce local IL-17A production as a treatment option for respiratory diseases.
authors: Pediatrics Division, University Hospitals Leuven, 3000 Leuven, Belgium.
authors: Dominique M A
authors: DM
authors: Bullens
authors: Ann
authors: A
authors: Decraene
authors: Sven
authors: S
authors: Seys
authors: Lieven J
authors: LJ
authors: Dupont
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D035843:Biomedical Research; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy; D020381:Interleukin-17 / Q000276:immunology*; D016209:Interleukin-8 / Q000276:immunology; D058990:Molecular Targeted Therapy; D018375:Neutrophil Activation; D012140:Respiratory Tract Diseases / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D016209:Interleukin-8
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