title: Prognostic significance of matrix metalloproteinases 2 and 9 in endometrial cancer.
abstract: We investigated the prognostic significance of matrix metalloproteinases 2 (MMP 2) and 9 (MMP 9) in endometrial cancer (EC). The expression of MMP 2 and MMP 9 was analyzed immunohistochemically in 73 primary EC patients. In most cases, the gelatinases were predominantly localized to epithelial cell of tumor origin. In univariate analysis histological type, tumor grade, FIGO (1988) surgical stage and high stromal MMP 2 expression were identified as a significant determinant for EC recurrence, while epithelial MMP 2 expression and epithelial and stromal MMP 9 expression were not. Multivariate analysis revealed a subgroup of patient age > or = 63.6 years with endometrioid adenocarcinoma and papillary serous carcinoma, all FIGO (2009) stage I disease where strong staining of stromal MMP 2 increase risk of EC recurrence (p = 0.037).
authors: University of Zagreb, "Sestre Milosrdnice" University Hospital Centre, University Hospital for Tumors, Department of Gynecologic Oncology, Zagreb, Croatia.
authors: Mario
authors: M
authors: Puljiz
authors: Zeljko
authors: Z
authors: Puljiz
authors: Tiha
authors: T
authors: Vucemilo
authors: Snjezana
authors: S
authors: Ramić
authors: Fabijan
authors: F
authors: Knezević
authors: Branimir
authors: B
authors: Culo
authors: Ilija
authors: I
authors: Alvir
authors: Darko
authors: D
authors: Tomica
authors: Damir
authors: D
authors: Danolić
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9