title: Comparison of an accelerated weighted fluorescence Monte Carlo simulation method with reference methods in multi-layered turbid media.
abstract: Monte Carlo (MC) simulations are frequently used to simulate the radial distribution of remitted fluorescence light from tissue surfaces upon pencil beam excitation to gather information about influences of different tissue parameters. Here, the "weighted direct emission method" (WDEM) is proposed, which uses a weighted MC simulation approach for both excitation and fluorescence photons, and is compared to four other methods in terms of accuracy and speed, and using a broad range of tissue-relevant optical parameters. The WDEM is 5.2× faster on average than a fixed weight MC approach while still preserving its accuracy. Additional gain of speed can be achieved by implementing it on graphics processing units.
authors: Laser-Forschungslabor, LIFE Center, Klinikum der Universität München, München 81377, Germany. georg.hennig@med.lmu.de
authors: Georg
authors: G
authors: Hennig
authors: Herbert
authors: H
authors: Stepp
authors: Ronald
authors: R
authors: Sroka
authors: Wolfgang
authors: W
authors: Beyer