title: Is rosmarinic acid underestimated as an experimental cardiovascular drug?
abstract: OBJECTIVE
  The rationale of the present review is to analize the activity of Rosmarinus officinalis in the the cardiovascular system
  
  
  METHODS
  A MEDLINE database search (from January 1970 to December 2011) using only rosmarinic acid as searched term.
  
  
  RESULTS
  The references search revealed 509 references about rosmarinic acid in 40 years (the first reference is from 1970). There is a powerful prevalence of antioxidant and cancer studies. Other diseases are few cited, as inflammation, brain (Alzheimer and Parkinson disease) and, memory; allergy; diabetes; atherosclerosis, and; hypertension. It is necessary to consider the complete absence of studies on coronary artery disease, myocardial ischemia, heart failure or ischemia/reperfusion injury.
  
  
  CONCLUSIONS
  Rosmarinic acid is underestimated as an experimental cardiovascular drug and deserves more attention.
authors: Postgraduate Program in Medical Surgical Clinic, Department of Surgery and Anatomy, Ribeirão Preto Faculty of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
authors: Luciana Garros
authors: LG
authors: Ferreira
authors: Andrea Carla
authors: AC
authors: Celotto
authors: Verena Kise
authors: VK
authors: Capellini
authors: Agnes Afrodite Sumarelli
authors: AA
authors: Albuquerque
authors: Tales Rubens de
authors: TR
authors: Nadai
authors: Marco Tulio Menezes de
authors: MT
authors: Carvalho
authors: Paulo Roberto Barbosa
authors: PR
authors: Evora
mesh_terms: D002317:Cardiovascular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D002934:Cinnamates / Q000494:pharmacology / Q000627:therapeutic use*; D053630:Depsides / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D000097123:Rosmarinic Acid
chemical_list: D002317:Cardiovascular Agents; D002934:Cinnamates; D053630:Depsides; D000097123:Rosmarinic Acid