title: Evaluation of long-term outcome for patients with renal cell carcinoma after surgery: analysis of cancer deaths occurring more than 10 years after initial treatment.
abstract: OBJECTIVE
  We evaluated the outcome of renal cell carcinoma (RCC) after surgery in a long-term follow-up study to elucidate the specific biological behaviors of RCC, such as late recurrence and late cancer-specific death.
  
  
  METHODS
  We retrospectively reviewed the clinical and pathological features of 625 patients who were diagnosed as having renal cell carcinoma at our institution from 1975 to 2006. We analyzed the parameters and outcomes for the patients who had received radical or partial nephrectomy. Pathological staging was reviewed again by two pathologists.
  
  
  RESULTS
  The median age of the patients was 61 years (range 16-87). The median follow-up was 7.0 years (range 0.1-30.3). Of the 516 patients with localized or locally advanced RCC, 124 (24.0 %) had recurrence after surgery. Lung metastasis was observed most frequently. The 10-year cancer-specific survival rates were 92.4, 91.0, 64.1 and 11.8 % for stages I, II, III and IV, respectively. The late recurrence rates in patients with localized and locally advanced RCC 5 and 10 years after initial surgery were 8.5 and 3.7 %, respectively. Cancer death more than 10 years after initial treatment of the disease occurred in 16 patients. Of the 16 patients, 9 had localized disease at the time of the initial surgery. Specific findings that characterized them were not identified in these patients.
  
  
  CONCLUSIONS
  Late recurrence of RCC is not rare. Cancer-specific death more than 10 years after the initial treatment was observed in 16 patients with localized or advanced disease. No specific findings were identified to characterize these patients with late cancer death.
authors: Department of Urology, Sapporo Medical University School of Medicine, S1W16, Chuo-ku, Sapporo, 060-8543, Japan.
authors: Yuki
authors: Y
authors: Kyoda
authors: Ko
authors: K
authors: Kobayashi
authors: Megumi
authors: M
authors: Hirobe
authors: Tetsuya
authors: T
authors: Shindo
authors: Fumimasa
authors: F
authors: Fukuta
authors: Kohei
authors: K
authors: Hashimoto
authors: Toshiaki
authors: T
authors: Tanaka
authors: Akiko
authors: A
authors: Tonooka
authors: Hiroshi
authors: H
authors: Kitamura
authors: Satoshi
authors: S
authors: Takahashi
authors: Naoya
authors: N
authors: Masumori
authors: Tadashi
authors: T
authors: Hasegawa
authors: Taiji
authors: T
authors: Tsukamoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D009392:Nephrectomy; D011379:Prognosis; D016896:Treatment Outcome
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