title: Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B.
abstract: The AIM2 (absent in melanoma 2) protein promotes host defenses against invading viruses and pathogenic bacteria through corresponding adapter molecules leading to the initiation of innate immune responses. We investigated the expression of AIM2 in peripheral blood mononuclear cells (PBMCs) from patients with acute hepatitis B (AHB) and chronic hepatitis B (CHB) during different clinical phases, and analyzed the correlation between AIM2 and clinical profiles in these groups. This study indicated that there is higher expression of AIM2, IL-1β, and IL-18 in AHB compared with expression in CHB. The expression of AIM2 mRNA was significantly negatively correlated with serum hepatitis B virus (HBV) load, HBeAg, and significantly positively correlated with IL-1β and IL-18 in AHB patients and CHB patients with immune clearance, which suggests that AIM2 expression is correlated with the immune clearance of HBV in the host. We summarized that there is a higher immune status in AHB, and a lower immune response in CHB. This suggests that the down-regulation of AIM2 may be associated with the chronic development of HB.
authors: Department of Genetics and Molecular Biology, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors: Dian-Lei
authors: DL
authors: Wu
authors: Guang-Hua
authors: GH
authors: Xu
authors: She-Min
authors: SM
authors: Lu
authors: Bo-Lin
authors: BL
authors: Ma
authors: Nai-Zhou
authors: NZ
authors: Miao
authors: Xiao-Bin
authors: XB
authors: Liu
authors: Yan-ping
authors: YP
authors: Cheng
authors: Ji-Hong
authors: JH
authors: Feng
authors: Zhi-Gang
authors: ZG
authors: Liu
authors: Feng-Ding
authors: Na-Liu
authors: Wei-qin
authors: WQ
authors: Li
authors: Ying-Ren
authors: YR
authors: Zhao
mesh_terms: D000208:Acute Disease; D000328:Adult; D015153:Blotting, Western; D004279:DNA, Viral / Q000097:blood / Q000276:immunology; D004268:DNA-Binding Proteins; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015870:Gene Expression / Q000276:immunology; D006509:Hepatitis B / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006513:Hepatitis B e Antigens / Q000097:blood / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D020382:Interleukin-18 / Q000097:blood / Q000276:immunology; D053583:Interleukin-1beta / Q000097:blood / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055815:Young Adult
chemical_list: C410167:AIM2 protein, human; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D006513:Hepatitis B e Antigens; D020382:Interleukin-18; D053583:Interleukin-1beta; D009687:Nuclear Proteins