title: Neutrophil-lymphocyte ratio and the platelet-lymphocyte ratio predict the limb survival in critical limb ischemia.
abstract: BACKGROUND
  The objective of this study was to evaluate whether admission neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) might reflect amputation in patients with critical limb ischemia (CLI) who could not get surgical or radiological (percutaneous transluminal angioplasty) revascularization.
  
  
  METHODS
  A total of 104 patients with nonreconstructable CLI over a 5-year period were collected prospectively.
  
  
  RESULTS
  Admission NLR levels of ≥3.2 and a PLR of ≥160 were found to represent the optimal cutoff values to risk stratification of patients. If both levels were elevated, patients had a median overall limb survival of 22 months. For cases where both levels were less than the cutoff values, the median overall limb survival time was not reached but was greater than 60 months.
  
  
  CONCLUSIONS
  Admission NLR and PLR both merit further evaluation as prognostic indices in patients with CLI.
authors: Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey irfantasoglu@yahoo.com.
authors: İrfan
authors: İ
authors: Taşoğlu
authors: Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey.
authors: Doğan
authors: D
authors: Sert
authors: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Necmettin
authors: N
authors: Colak
authors: Department of Cardiovascular Surgery, Fatih Unıversty Medical Faculty, Ankara, Turkey.
authors: Alper
authors: A
authors: Uzun
authors: Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey.
authors: Murat
authors: M
authors: Songur
authors: Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey.
authors: Ata
authors: A
authors: Ecevit
mesh_terms: D000368:Aged; D001792:Blood Platelets; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000401:mortality*; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010976:Platelet Count; D015996:Survival Rate
keywords: atherosclerosis; thrombosis; vascular and endovascular surgery; vascular disease