title: Clinical applications of FDG-probe guided surgery.
abstract: BACKGROUND
  For a definitive diagnosis in many oncological, inflammatory and infectious diseases histological examination is required. Non-palpable lesions detected with PET/CT scanning that cannot be localized with conventional imaging methods can be localized and excised using FDG-probe guided surgery. We describe the application of FDG-probe guided surgery in 9 patients.
  
  
  METHODS
  The application of FDG-probe guided surgery used in 9 consecutive patients with oncological and infectious diseases is described. Four hours before surgery, 3.5 MBq/Kg body weight FDG was intravenously administered after which a FDG-PET-scan was performed to confirm the FDG-avid lesion(s). The lesions with highest activity were detected with the FDG-probe and the lesions were subsequently excised and sent for histopathological examination.
  
  
  RESULTS
  In all of the 9 cases the target lesion was successfully identified and subsequently removed. When multiple and/or macroscopically normal lymph nodes were found, the use of the FDG-probe allowed selection of the PET-avid lymph nodes for resection.
  
  
  CONCLUSIONS
  FDG-probe guided surgery is a relatively simple surgical technique to identify and excise FDG-accumulating suspicious lesions in oncological, inflammatory and infectious diseases.
authors: Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands. c.vos@vumc.nl
authors: C G
authors: CG
authors: Vos
authors: K J
authors: KJ
authors: Hartemink
authors: S
authors: S
authors: Muller
authors: J W A
authors: JW
authors: Oosterhuis
authors: S
authors: S
authors: Meijer
authors: M Petrousjka
authors: MP
authors: van den Tol
authors: E F I
authors: EF
authors: Comans
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000473:pathology; D025321:Surgery, Computer-Assisted
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18