title: Clinical and endoscopic features of angiosarcoma of the colon: two case reports and a review of the literature.
abstract: BACKGROUND
  Angiosarcoma of the gastrointestinal tract is an extremely rare tumor. We present two cases of angiosarcoma of the colon. One patient developed syncope and anemia and the other had rectal bleeding.
  
  
  CONCLUSIONS
  Endoscopic findings of the colon were different; the first case demonstrated a reddened colonic fold without an obvious mass and the other had an ulcerated friable mass. Both of the tumors had positive immunohistochemical stains for CD31 and CD34 (one was also positive for CD117). Surgery was not performed in either case. Treatment included chemotherapy with imatinib for the first patient and paclitaxel for the second. Prognosis for this tumor is generally poor; in our cases, one patient was still alive after 5 months of follow-up and the other died within 2 months of diagnosis. After presenting our cases, we reviewed the current literature on angiosarcoma of the colon.
authors: Saint Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA.
authors: Muhammed
authors: M
authors: Sherid
authors: Humberto
authors: H
authors: Sifuentes
authors: Jeff
authors: J
authors: Brasky
authors: Dhiren A
authors: DA
authors: Shah
authors: Eli D
authors: ED
authors: Ehrenpreis
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001549:Benzamides / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D016145:Endoscopy, Digestive System; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy; D006394:Hemangiosarcoma / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D000068877:Imatinib Mesylate; D017239:Paclitaxel / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D012196:Review Literature as Topic; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D017239:Paclitaxel
references: Acta Gastroenterol Belg. 1999 Apr-Jun;62(2):248-51
references: 10427792
references: J Clin Gastroenterol. 1989 Feb;11(1):77-81
references: 2921494
references: J Surg Educ. 2007 Jan-Feb;64(1):54-6
references: 17320808
references: Oncologist. 2012;17(2):260-6
references: 22285963
references: Clin Nucl Med. 1987 Nov;12(11):845-7
references: 3427855
references: Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):628-33
references: 21045382
references: J Clin Oncol. 2009 Sep 20;27(27):e116-7
references: 19667271
references: Colorectal Dis. 2008 Oct;10(8):847-8
references: 18294267
references: Dis Colon Rectum. 1987 Sep;30(9):707-11
references: 3622180
references: Int J Colorectal Dis. 2005 Jul;20(4):385-7
references: 15959792
references: J Cutan Pathol. 2011 Dec;38(12):961-6
references: 22050093
references: Indian J Gastroenterol. 1995 Jan;14(1):31-2
references: 7860121
references: Ann Pathol. 1991;11(1):25-30
references: 2036131
references: Neoplasia. 2012 Feb;14(2):131-40
references: 22431921
references: Dis Colon Rectum. 1994 Dec;37(12):1277-80
references: 7995158
references: J Clin Ultrasound. 2008 Feb;36(2):110-2
references: 17636504
references: J Surg Oncol. 1996 Mar;61(3):170-6
references: 8637202
references: Am J Surg Pathol. 2004 Mar;28(3):298-307
references: 15104292
references: Virchows Arch A Pathol Anat Histopathol. 1993;423(4):309-14
references: 8236827
references: Hiroshima J Med Sci. 2011 Dec;60(4):91-6
references: 22389954
references: Ann Surg. 1949 Apr;129(4):538-42
references: 17859337
references: Dis Colon Rectum. 1990 Apr;33(4):330-3
references: 2182313
references: Cancer. 1988 Jul 1;62(1):210-6
references: 3383117
references: Am J Clin Pathol. 1992 Mar;97(3):416-20
references: 1543166
references: Acta Chir Belg. 2004 Aug;104(4):465-7
references: 15469166
references: Rev Esp Enferm Dig. 2010 Apr;102(4):288-9
references: 20486756
references: Gastrointest Endosc. 2006 Feb;63(2):330; discussion 330
references: 16427950
references: Tumori. 2005 Mar-Apr;91(2):210-2
references: 15948556
references: Tidsskr Nor Laegeforen. 1991 Oct 20;111(25):3068-9
references: 1948921
references: Cancer. 1991 May 1;67(9):2275-9
references: 2013033
references: Dis Colon Rectum. 2004 Dec;47(12):2202-7
references: 15657674
references: Zentralbl Allg Pathol. 1959 May 30;99(7-8):352-7
references: 13676674
references: Arch Pathol Lab Med. 2001 Jul;125(7):968-70
references: 11419990