title: Trifluoroethanol solvent facilitates selective N-7 methylation of purines.
abstract: Purines protected at N-9 by p-methoxybenzyl are methylated or ethylated in 2,2,2-trifluoroethanol at N-7 by trimethyl- or triethyl-oxonium borofluorate, respectively. Subjecting the resulting cationic species to microwave irradiation releases an N(7)-methyl- or ethyl-purine. This one-pot procedure is an efficient regiospecific method applicable to diverse substrates.
authors: Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom.
authors: Honorine
authors: H
authors: Lebraud
authors: Celine
authors: C
authors: Cano
authors: Benoit
authors: B
authors: Carbain
authors: Ian R
authors: IR
authors: Hardcastle
authors: Ross W
authors: RW
authors: Harrington
authors: Roger J
authors: RJ
authors: Griffin
authors: Bernard T
authors: BT
authors: Golding
mesh_terms: D018360:Crystallography, X-Ray; D008745:Methylation; D008872:Microwaves; D008958:Models, Molecular; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D014270:Trifluoroethanol / Q000737:chemistry*
chemical_list: D011687:Purines; D012997:Solvents; D014270:Trifluoroethanol