title: Mitotic control of cancer stem cells.
abstract: Cancer stem cells are self-renewing, tumorigenic cells at the apex of tumor hierarchies, and postulated to be quiescent in many tumor types. This issue of Cancer Discovery highlights a study that links the presentation of kinetochores within mitosis to an essential requirement for BUB1B/BubR1, broadening our understanding of the cell-cycle machinery in cancer stem cells.
authors: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors: Monica
authors: M
authors: Venere
authors: Tyler E
authors: TE
authors: Miller
authors: Jeremy N
authors: JN
authors: Rich
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics*; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
chemical_list: C584277:BUB1 protein, human; C090464:Bub1 spindle checkpoint protein; D017346:Protein Serine-Threonine Kinases
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