title: Pulmonary hypertension associated with diffuse deposition of pentosidine in pulmonary arterioles.
abstract: Diabetes induces advanced glycation end products (AGEs) that per se are not only a major cause of oxidative stress but also reduce the plasticity of connective tissue by pathological collagen cross-linking. We describe a case of severe pulmonary hypertension manifesting as a major diabetic complication. Impaired pulmonary arteriolar plasticity attributed to pentosidine, together with increased circulation volume by hyperosmotic pressure and reduction in myocardial compliance by multiple patchy fibrosis, may contribute to the clinical manifestation of severe pulmonary hypertension.
authors: Division of Molecular Pathology, Ehime University Graduate School of Medicine, Shitsukawa 454, Toon City, Ehime 791-0295, Japan.
authors: Komoda
authors: K
authors: Munenori
authors: Riko
authors: R
authors: Kitazawa
authors: Kenji
authors: K
authors: Makita
authors: Keisuke
authors: K
authors: Yoshida
authors: Miyuki
authors: M
authors: Takeji
authors: Yoshiko
authors: Y
authors: Soga
authors: Mie
authors: M
authors: Kurata
authors: Ryuma
authors: R
authors: Haraguchi
authors: Sohei
authors: S
authors: Kitazawa
mesh_terms: D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism*; D008239:Lysine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D001120:Arginine; C062187:pentosidine; D008239:Lysine