title: Dexamethasone effect on postoperative pain and tramadol requirement after thyroidectomy.
abstract: Tramadol is a central-acting analgesic associated with nausea and vomiting. Clinical studies have demonstrated that glucocorticoids have analgesic and antiemetic effects when administered perioperatively. The aim of this study is to test the hypothesis that coadministration of tramadol and dexamethasone decreases both postoperative pain and tramadol requirement by patient-controlled analgesia (PCA). Forty female patients undergoing thyroidectomy under general anesthesia were enrolled in a double-blind randomized controlled study and allocated to receive dexamethasone 4 mg i.v. (dexamethasone group, n = 20) or saline (control group, n = 20). At 0, 1, 2, 4 and 22 h of PCA, tramadol consumption and pain were evaluated. Although pain (numerical rating scale 0-10) was significantly lower in the dexamethasone group compared to the control group (2.9 ± 1.4 vs. 3.8 ± 1.2, p = 0.02) at the beginning of PCA, tramadol demand was not significantly different. Although the results herein show a possible beneficial effect of a preoperative single low dose of dexamethasone on postoperative pain, the hypothesis that this corticosteroid decreases tramadol requirement is not supported.
authors: Department of Anaesthesiology, Centro Hospitalar Tondela-Viseu, E.P.E, Viseu, Portugal.
authors: Ana
authors: A
authors: Barros
authors: Carolina P
authors: CP
authors: Vale
authors: Fátima C
authors: FC
authors: Oliveira
authors: Celso
authors: C
authors: Ventura
authors: Josép
authors: J
authors: Assunção
authors: Carlos Alberto
authors: CA
authors: Fontes Ribeiro
authors: Frederico C
authors: FC
authors: Pereira
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000932:Antiemetics / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control; D010149:Postoperative Pain / Q000188:drug therapy*; D013965:Thyroidectomy; D014147:Tramadol / Q000008:administration & dosage*; D014839:Vomiting / Q000517:prevention & control
chemical_list: D000701:Analgesics, Opioid; D000932:Antiemetics; D014147:Tramadol; D003907:Dexamethasone