title: Caprolactam-silica network, a strong potentiator of the antimicrobial activity of kanamycin against gram-positive and gram-negative bacterial strains.
abstract: Here, we report the fabrication of a novel ε-caprolactam-silica (ε-SiO2) network and assessed its biocompatibility and ability to improve the antimicrobial activity of kanamycin. The results of the quantitative antimicrobial assay demonstrate that the obtained ε-SiO2 network has efficiently improved the kanamycin activity on Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 strains, with a significant decrease of the minimum inhibitory concentration. The ε-SiO2 network could be feasibly obtained and represents an alternative for the design of new antibiotic drug carriers or delivery systems to control bacterial infections.
authors: Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest 011061, Romania.
authors: Georgeta
authors: G
authors: Voicu
authors: Valentina
authors: V
authors: Grumezescu
authors: Ecaterina
authors: E
authors: Andronescu
authors: Alexandru Mihai
authors: AM
authors: Grumezescu
authors: Anton
authors: A
authors: Ficai
authors: Denisa
authors: D
authors: Ficai
authors: Cristina Daniela
authors: CD
authors: Ghitulica
authors: Irina
authors: I
authors: Gheorghe
authors: Mariana Carmen
authors: MC
authors: Chifiriuc
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D002209:Caprolactam / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D007612:Kanamycin / Q000008:administration & dosage* / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D012822:Silicon Dioxide / Q000008:administration & dosage* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D007612:Kanamycin; D002209:Caprolactam; D012822:Silicon Dioxide