title: Sonography of the median nerve in CMT1A, CMT2A, CMTX, and HNPP.
abstract: BACKGROUND
  In this study we compare the ultrasound features in the median nerve in patients with different types of Charcot-Marie-Tooth (CMT) disease and hereditary neuropathies with liability to pressure palsies (HNPP) as a typical entrapment neuropathy.
  
  
  METHODS
  Median nerve ultrasound and conduction studies were performed in patients with CMT1A (n = 12), MFN2-associated CMT2A (n = 7), CMTX (n = 5), and HNPP (n = 5), and in controls (n = 28).
  
  
  RESULTS
  Median nerve cross-sectional area (CSA) was significantly increased in CMT1A, whereas, in axonal CMT2A, fascicle diameter (FD) was enlarged. CSA correlated with nerve conduction slowing in CMT1A and with axonal loss, as shown by motor and sensory nerve amplitudes in both CMT1A and CMT2A. A relatively low wrist-to-forearm-ratio (WFR <0.8) or a relatively high WFR (>1.8) appeared to be unlikely in MFN2 and Cx32 mutations of CMT2A and CMTX, respectively.
  
  
  CONCLUSIONS
  Differences in CSA, FD, and WFR of the median nerve can be helpful in defining subtypes of hereditary neuropathies.
authors: Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany. stefanie.schreiber@med.ovgu.de
authors: Stefanie
authors: S
authors: Schreiber
authors: Andreas
authors: A
authors: Oldag
authors: Cornelia
authors: C
authors: Kornblum
authors: Katja
authors: K
authors: Kollewe
authors: Siegfried
authors: S
authors: Kropf
authors: Ariel
authors: A
authors: Schoenfeld
authors: Helmut
authors: H
authors: Feistner
authors: Sibylle
authors: S
authors: Jakubiczka
authors: Wolfram S
authors: WS
authors: Kunz
authors: Cordula
authors: C
authors: Scherlach
authors: Claus
authors: C
authors: Tempelmann
authors: Christian
authors: C
authors: Mawrin
authors: Reinhard
authors: R
authors: Dengler
authors: Frank
authors: F
authors: Schreiber
authors: Michael
authors: M
authors: Goertler
authors: Stefan
authors: S
authors: Vielhaber
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002607:Charcot-Marie-Tooth Disease / Q000000981:diagnostic imaging* / Q000235:genetics; D017630:Connexins / Q000235:genetics; D004568:Electrodiagnosis; D055724:Electrophysiological Phenomena; D005260:Female; D005542:Forearm / Q000033:anatomy & histology / Q000294:innervation; D020558:GTP Phosphohydrolases / Q000235:genetics; D015417:Hereditary Sensory and Motor Neuropathy / Q000000981:diagnostic imaging* / Q000235:genetics; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D008475:Median Nerve / Q000000981:diagnostic imaging*; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics; D009185:Myelin Proteins / Q000235:genetics; D009431:Neural Conduction / Q000502:physiology; D010641:Phenotype; D014463:Ultrasonography; D014953:Wrist / Q000033:anatomy & histology / Q000294:innervation; D055815:Young Adult; D000097002:Gap Junction beta-1 Protein
chemical_list: D017630:Connexins; D020558:GTP Phosphohydrolases; D024101:Mitochondrial Proteins; D009185:Myelin Proteins; D000097002:Gap Junction beta-1 Protein; C073687:PMP22 protein, human; C470018:MFN2 protein, human