title: Cerebellar contributions to visuomotor adaptation and motor sequence learning: an ALE meta-analysis.
abstract: Cerebellar contributions to motor learning are well-documented. For example, under some conditions, patients with cerebellar damage are impaired at visuomotor adaptation and at acquiring new action sequences. Moreover, cerebellar activation has been observed in functional MRI (fMRI) investigations of various motor learning tasks. The early phases of motor learning are cognitively demanding, relying on processes such as working memory, which have been linked to the cerebellum as well. Here, we investigated cerebellar contributions to motor learning using activation likelihood estimation (ALE) meta-analysis. This allowed us to determine, across studies and tasks, whether or not the location of cerebellar activation is constant across differing motor learning tasks, and whether or not cerebellar activation in early learning overlaps with that observed for working memory. We found that different regions of the anterior cerebellum are engaged for implicit and explicit sequence learning and visuomotor adaptation, providing additional evidence for the modularity of cerebellar function. Furthermore, we found that lobule VI of the cerebellum, which has been implicated in working memory, is activated during the early stages of explicit motor sequence learning. This provides evidence for a potential role for the cerebellum in the cognitive processing associated with motor learning. However, though lobule VI was activated across both early explicit sequence learning and working memory studies, there was no spatial overlap between these two regions. Together, our results support the idea of modularity in the formation of internal representations of new motor tasks in the cerebellum, and highlight the cognitive processing relied upon during the early phases of motor skill learning.
authors: Department of Neurology, University of Colorado Denver School of Medicine Aurora, CO, USA.
authors: Jessica A
authors: JA
authors: Bernard
authors: Rachael D
authors: RD
authors: Seidler
keywords: cerebellum; meta-analysis; sequence learning; visuomotor adaptation; working memory
references: Neuroimage. 2008 Oct 1;42(4):1678-85
references: 18586110
references: Neuroimage. 2005 Aug 15;27(2):377-86
references: 15893942
references: J Cogn Neurosci. 2004 Jan-Feb;16(1):127-38
references: 15006042
references: Brain. 1997 Jan;120 ( Pt 1):123-40
references: 9055803
references: J Neurophysiol. 2011 Jun;105(6):3042-53
references: 21471398
references: PLoS One. 2010 Apr 22;5(4):e10298
references: 20421978
references: Neuroimage. 2011 Jun 1;56(3):1758-72
references: 21376126
references: J Neurophysiol. 2009 Jun;101(6):3116-25
references: 19357338
references: J Neurophysiol. 2012 Jan;107(1):134-47
references: 21975446
references: Epilepsia. 2009 Nov;50(11):2456-65
references: 19490045
references: Exp Brain Res. 2006 Nov;175(3):544-55
references: 16794848
references: Curr Opin Neurobiol. 2005 Apr;15(2):161-7
references: 15831397
references: Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12566-71
references: 16107540
references: J Cogn Neurosci. 2001 Feb 15;13(2):217-31
references: 11244547
references: Neuroimage. 2007 Mar;35(1):368-77
references: 17239618
references: Psychosom Med. 2006 Nov-Dec;68(6):947-55
references: 17079703
references: Nature. 2000 Jan 13;403(6766):192-5
references: 10646603
references: Brain Res Cogn Brain Res. 2002 Aug;14(2):277-93
references: 12067701
references: Cereb Cortex. 2011 Aug;21(8):1901-9
references: 21239392
references: J Cogn Neurosci. 2010 Sep;22(9):1917-30
references: 19803691
references: Brain Res Cogn Brain Res. 2004 Nov;21(3):377-87
references: 15511653
references: Mem Cognit. 2005 Mar;33(2):213-20
references: 16028576
references: Cereb Cortex. 2011 Aug;21(8):1761-70
references: 21139077
references: Neuroimage. 2010 Apr 15;50(3):1303-12
references: 20079855
references: Hum Brain Mapp. 2014 Feb;35(2):593-615
references: 23125108
references: Nat Neurosci. 2005 May;8(5):594-6
references: 15821730
references: Neuroimage. 2005 Jan 15;24(2):332-8
references: 15627576
references: Sleep. 2005 Apr;28(4):433-46
references: 16171288
references: Exp Brain Res. 2002 Oct;146(3):369-78
references: 12232693
references: Scand J Psychol. 2001 Jul;42(3):217-24
references: 11501736
references: Neurobiol Learn Mem. 2001 Nov;76(3):342-57
references: 11726241
references: Behav Neurol. 2010;23(1-2):51-63
references: 20714061
references: Brain. 1996 Jun;119 ( Pt 3):1023-9
references: 8673479
references: Psychiatry Res. 2005 Oct 30;140(1):73-83
references: 16139997
references: Neuroimage. 2004 Jan;21(1):340-51
references: 14741672
references: Neuroimage. 2007 Jul 1;36(3):943-54
references: 17468013
references: Neuroimage. 2003 Feb;18(2):247-56
references: 12595179
references: Brain Res. 2008 Mar 27;1201:114-21
references: 18294618
references: Neuroimage. 2005 Jan 15;24(2):462-72
references: 15627588
references: Neural Netw. 1996 Nov;9(8):1265-1279
references: 12662535
references: Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5461-6
references: 12704240
references: MAGMA. 2005 May;18(2):96-102
references: 15711850
references: Hum Brain Mapp. 2005 Mar;24(3):216-28
references: 15543553
references: Neuroimage. 2012 Jan 16;59(2):1560-70
references: 21907811
references: Brain. 1998 Apr;121 ( Pt 4):561-79
references: 9577385
references: J Cogn Neurosci. 2010 Apr;22(4):655-69
references: 19320550
references: J Neurophysiol. 2010 Jun;103(6):3330-6
references: 20393055
references: Hum Brain Mapp. 2011 May;32(5):771-83
references: 20533560
references: J Neurophysiol. 2009 Nov;102(5):2744-54
references: 19726728
references: Brain Res Cogn Brain Res. 2005 Mar;22(3):373-83
references: 15722208
references: Science. 1997 Aug 8;277(5327):821-5
references: 9242612
references: Neuropsychologia. 2000;38(4):426-40
references: 10683393
references: Brain Res. 2007 Dec 14;1185:136-51
references: 17996854
references: Psychiatry Res. 2004 Nov 15;132(1):19-32
references: 15546700
references: J Cogn Neurosci. 2011 Jan;23(1):11-25
references: 20146609
references: Neuroimage. 2006 Jan 1;29(1):1-14
references: 16095920
references: J Neurophysiol. 2005 Jul;94(1):512-8
references: 15716371
references: Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1017-22
references: 11805340
references: Neuroimage. 2009 May 15;46(1):39-46
references: 19457380
references: J Affect Disord. 2007 Aug;101(1-3):175-85
references: 17197035
references: Neuroimage. 2006 Aug 15;32(2):714-27
references: 16798015
references: Neuroimage. 1999 Sep;10(3 Pt 1):327-38
references: 10458945
references: J Neurophysiol. 2002 Oct;88(4):2035-46
references: 12364526
references: Neuroimage. 2002 Jul;16(3 Pt 1):765-80
references: 12169260
references: Neuroimage. 2009 Jan 15;44(2):489-501
references: 18835452
references: Neuroimage. 2000 Nov;12(5):495-503
references: 11034857
references: J Neurophysiol. 2011 Nov;106(5):2322-45
references: 21795627
references: Neuroimage. 2007 Feb 1;34(3):1253-69
references: 17175179
references: J Mot Behav. 1993 Sep;25(3):203-16
references: 12581990
references: Nat Rev Neurosci. 2006 Jul;7(7):511-22
references: 16791141
references: Brain Res. 2000 Dec 15;886(1-2):237-245
references: 11119699
references: Neurobiol Aging. 2003 Nov;24(7):1013-9
references: 12928061
references: Sleep. 2005 Jan;28(1):55-67
references: 15700721
references: Neuroimage. 2010 Jan 1;49(1):694-702
references: 19732838
references: Behav Neurol. 2010;23(1-2):65-79
references: 20714062
references: Hum Brain Mapp. 2007 Nov;28(11):1194-205
references: 17266101
references: Neuropsychologia. 2007 Nov 5;45(14):3203-14
references: 17689571
references: Neuroreport. 2000 Feb 28;11(3):609-15
references: 10718323
references: J Psychiatr Res. 2008 May;42(6):469-76
references: 17559877
references: J Neurosci. 2011 Jul 27;31(30):10882-90
references: 21795540
references: Hum Brain Mapp. 2009 Sep;30(9):2907-26
references: 19172646
references: Neuroimage. 2007 Apr 15;35(3):1264-77
references: 17346989
references: Science. 1966 Aug 5;153(3736):652-4
references: 5939936
references: Br J Psychiatry. 2004 Sep;185:205-14
references: 15339824
references: Exp Brain Res. 2012 Sep;221(4):467-77
references: 22836520
references: Neuroimage. 1999 Sep;10(3 Pt 1):233-60
references: 10458940
references: Am J Psychiatry. 2003 May;160(5):919-23
references: 12727696
references: Exp Brain Res. 2011 Sep;214(1):73-81
references: 21809082
references: Nat Rev Neurosci. 2008 Apr;9(4):304-13
references: 18319727
references: Neuropsychologia. 2005;43(9):1227-37
references: 15949507
references: Biol Psychiatry. 2004 Sep 1;56(5):323-32
references: 15336514
references: J Neurosci. 1994 Jun;14(6):3775-90
references: 8207487
references: Brain Res Cogn Brain Res. 2004 Jul;20(2):120-31
references: 15183385
references: Front Hum Neurosci. 2012 Oct 19;6:289
references: 23125826
references: J Neurosci. 2009 Jan 7;29(1):169-78
references: 19129395
references: J Cogn Neurosci. 2004 May;16(4):621-36
references: 15165352
references: Neuroimage. 2003 Aug;19(4):1510-20
references: 12948707
references: Neuron. 2003 Mar 27;37(6):1013-25
references: 12670429
references: Nat Neurosci. 2000 Nov;3 Suppl:1212-7
references: 11127840
references: Neuroimage. 2008 Jan 1;39(1):492-9
references: 17936643
references: J Neurophysiol. 2004 Feb;91(2):924-33
references: 14523069
references: Front Neuroanat. 2012 Aug 10;6:31
references: 22907994
references: Neuroimage. 2012 Feb 1;59(3):2923-31
references: 21985908
references: Hum Brain Mapp. 2005 May;25(1):155-64
references: 15846811
references: Brain. 1998 Nov;121 ( Pt 11):2159-73
references: 9827775
references: Exerc Sport Sci Rev. 2010 Jan;38(1):3-9
references: 20016293
references: J Neurosci. 2011 Sep 28;31(39):13739-45
references: 21957237
references: Neuroimage. 2006 Oct 15;33(1):127-38
references: 16904911
references: IEEE Trans Med Imaging. 1998 Jun;17(3):463-8
references: 9735909
references: Brain. 2003 Jan;126(Pt 1):71-94
references: 12477698
references: Hum Brain Mapp. 2010 Jan;31(1):115-25
references: 19603410
references: Neuron. 2008 Apr 24;58(2):261-72
references: 18439410
references: Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8108-13
references: 18523017