title: Shigella strains are not clones of Escherichia coli but sister species in the genus Escherichia.
abstract: Shigella species and Escherichia coli are closely related organisms. Early phenotyping experiments and several recent molecular studies put Shigella within the species E. coli. However, the whole-genome-based, alignment-free and parameter-free CVTree approach shows convincingly that four established Shigella species, Shigella boydii, Shigella sonnei, Shigella felxneri and Shigella dysenteriae, are distinct from E. coli strains, and form sister species to E. coli within the genus Escherichia. In view of the overall success and high resolution power of the CVTree approach, this result should be taken seriously. We hope that the present report may promote further in-depth study of the Shigella-E. coli relationship.
authors: T-Life Research Center and Department of Physics, Fudan University, Shanghai 200433, China.
authors: Guanghong
authors: G
authors: Zuo
authors: Zhao
authors: Z
authors: Xu
authors: Bailin
authors: B
authors: Hao
mesh_terms: D004925:Escherichia / Q000145:classification* / Q000235:genetics; D004926:Escherichia coli / Q000145:classification / Q000235:genetics; D016680:Genome, Bacterial; D010802:Phylogeny; D012760:Shigella / Q000145:classification* / Q000235:genetics; D012761:Shigella boydii / Q000145:classification / Q000235:genetics; D012762:Shigella dysenteriae / Q000145:classification / Q000235:genetics; D012764:Shigella sonnei / Q000145:classification / Q000235:genetics
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