title: Sonodynamic therapy inhibits angiogenesis and tumor growth in a xenograft mouse model.
abstract: Studies of sonodynamic therapy (SDT) have mainly focused on its direct cytotoxic effect on tumor cells. Its effects on the tumor microenvironment, especially angiogenesis, remain unknown. In this study, we found that SDT significantly inhibited endothelial cell proliferation, migration, invasion, and tube formation. Furthermore, in a tumor xenograft mouse model, SDT was found to remarkably suppress tumor growth, intratumoral vascularity, and expression of vascular endothelial growth factor in tumor cells. An ultrastructural study showed damage and disruption of tumor microvasculature after STD. Our results indicate that SDT inhibits neovascularization in tumor, which is partially responsible for the anti-tumor effect of SDT.
authors: Laboratory of Sono- and Photo-theranostic Technologies, Harbin Institute of Technology, Harbin 150080, China.
authors: Zhongxiuzi
authors: Z
authors: Gao
authors: Jinhua
authors: J
authors: Zheng
authors: Bin
authors: B
authors: Yang
authors: Zhu
authors: Z
authors: Wang
authors: Haixia
authors: H
authors: Fan
authors: Yanhong
authors: Y
authors: Lv
authors: Haixia
authors: H
authors: Li
authors: Limin
authors: L
authors: Jia
authors: Wenwu
authors: W
authors: Cao
mesh_terms: D000622:Aminolevulinic Acid / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects / Q000528:radiation effects; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D055806:Microvessels / Q000473:pathology / Q000528:radiation effects; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology / Q000532:radiotherapy*; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology / Q000627:therapeutic use; D013010:Sonication; D013016:Sound; D047368:Tumor Burden / Q000187:drug effects / Q000528:radiation effects; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D011838:Radiation-Sensitizing Agents; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000622:Aminolevulinic Acid