title: Assessment of protective effects of pheniramine maleate on reperfusion injury in lung after distant organ ischemia: a rat model.
abstract: OBJECTIVE
  The aim of this study is to investigate the protective effects of methylprednisolone (MP) and pheniramine maleate (PM) on reperfusion injury of lungs developing after ischemia of the left lower extremity of rats.
  
  
  METHODS
  A total of 28 randomly selected male rats were divided into 4 groups, each consisting of 7 rats. Group 1 was the control group. Group 2 was the sham group (ischemia/reperfusion [I/R]). Rats in group 3 were subjected to I/R and given PM (Ph group) and rats in group 4 were subjected to I/R and given MP (Pn group).
  
  
  RESULTS
  Malondialdehyde levels were significantly lower in Ph group than in I/R group (P < .05). Superoxide dismutase and glutathione peroxidase enzyme activities were found to be significantly higher in Ph group than in the I/R group (P < .05). Histological examination demonstrated that PM had protective effects against I/R injury.
  
  
  CONCLUSIONS
  The PM has a protective effect against I/R injury in rat lung.
authors: Department of Cardiovascular Surgery, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey. gokalporhan@yahoo.com
authors: Orhan
authors: O
authors: Gokalp
authors: Ismail
authors: I
authors: Yurekli
authors: Muge
authors: M
authors: Kiray
authors: Alper
authors: A
authors: Bagriyanik
authors: Ufuk
authors: U
authors: Yetkin
authors: Banu Sarer
authors: BS
authors: Yurekli
authors: Serkan
authors: S
authors: Gur
authors: Murat
authors: M
authors: Aksun
authors: Ismail Safa
authors: IS
authors: Satoglu
authors: Gamze
authors: G
authors: Gokalp
authors: Ali
authors: A
authors: Gurbuz
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D019610:Cytoprotection; D004195:Disease Models, Animal; D005979:Glutathione Peroxidase / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007511:Ischemia / Q000150:complications / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects; D035002:Lower Extremity / Q000098:blood supply*; D008168:Lung / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D055370:Lung Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008775:Methylprednisolone / Q000494:pharmacology; D010632:Pheniramine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D006634:Histamine H1 Antagonists; D010632:Pheniramine; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D008775:Methylprednisolone