title: Computationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4).
abstract: A structure-based computational approach was used to rationally design peptide inhibitors that can target an E3 ligase (SCF(Fbx4) )-substrate (TRF1) interface and subsequent ubiquitylation. Characterization of the inhibitors demonstrates that our sequence-optimization protocol results in an increase in peptide-TRF1 affinity without compromising peptide-protein specificity.
authors: Department of Chemistry and Biochemistry, 596 UCB, University of Colorado, JSCBB 3415 Colorado Avenue, Boulder, CO 80309-0215, USA.
authors: Junglim
authors: J
authors: Lee
authors: Deanne W
authors: DW
authors: Sammond
authors: Zeno
authors: Z
authors: Fiorini
authors: Jonel P
authors: JP
authors: Saludes
authors: Michael G
authors: MG
authors: Resch
authors: Bing
authors: B
authors: Hao
authors: Wei
authors: W
authors: Wang
authors: Hang
authors: H
authors: Yin
authors: Xuedong
authors: X
authors: Liu
mesh_terms: D000595:Amino Acid Sequence; D015195:Drug Design; D044783:F-Box Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D010455:Peptides / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects*; D060066:Protein Interaction Maps / Q000187:drug effects; D035321:Telomeric Repeat Binding Protein 1 / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D054875:Ubiquitination / Q000187:drug effects
chemical_list: D044783:F-Box Proteins; C508146:FBXO4 protein, human; D010455:Peptides; D035321:Telomeric Repeat Binding Protein 1
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