title: Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease.
abstract: Breeding of genetically resistant chickens to Marek's disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNVs were found in four lines of chickens, and 28 were potentially involved in immune response and cell proliferation, etc. Importantly, two CNVs related with MD resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may lead to better strategies for genetic improvement of disease resistance in poultry.
authors: Department of Animal & Avian Sciences, University of Maryland, College Park, Maryland 20742, USA.
authors: Juan
authors: J
authors: Luo
authors: Ying
authors: Y
authors: Yu
authors: Apratim
authors: A
authors: Mitra
authors: Shuang
authors: S
authors: Chang
authors: Huanmin
authors: H
authors: Zhang
authors: George
authors: G
authors: Liu
authors: Ning
authors: N
authors: Yang
authors: Jiuzhou
authors: J
authors: Song
mesh_terms: D000818:Animals; D002645:Chickens / Q000235:genetics*; D056915:DNA Copy Number Variations; D060467:Disease Resistance / Q000235:genetics; D004198:Disease Susceptibility / Q000662:veterinary; D015870:Gene Expression; D016678:Genome; D008380:Marek Disease / Q000235:genetics* / Q000473:pathology; D040641:Quantitative Trait Loci
keywords: CNV; Marek’s disease; chicken; disease resistance
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