title: Cerebellar mutism.
abstract: Cerebellar mutism occurs in about 25% of children following posterior fossa tumor surgery. It is usually accompanied by other neurological and behavioral disturbances. Mutism is transient in nature lasting several days to months and is frequently followed by dysarthria. In addition, impairment of language and other neuropsychological functions can be found after long term follow up in the majority of patients. The pathophysiological background of mutism may be higher speech dysfunction mediated by crossed cerebello-cerebral diaschisis which is frequently found during the mute period. Foremost injury to the bilateral dentatothalamocortical tract appears to be critical for the development of cerebello-cerebral diaschisis and subsequent mutism. Direct cerebellar injury is the likely reason for persisting deficits after the mute period. Minimization of injury to the dentatothalamocortical tract during surgery may be promising in the prevention of mutism. While there is no established treatment of mutism, early speech and rehabilitation therapy is recommended.
authors: Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany. Electronic address: Michael.Kueper@uni-due.de.
authors: Michael
authors: M
authors: Küper
authors: Dagmar
authors: D
authors: Timmann
mesh_terms: D002531:Cerebellum / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D015192:Infratentorial Neoplasms / Q000150:complications / Q000601:surgery; D008297:Male; D009155:Mutism / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D011183:Postoperative Complications / Q000503:physiopathology
keywords: Dentatothalamocortical tract; Diaschisis; Dysarthria; Medulloblastoma; Posterior fossa syndrome