title: Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain Pseudomonas aurantiaca PB-St2.
abstract: Three new aromatic acids, named lahorenoic acids A (1), B (2), and C (3), have been isolated along with the known compounds phenazine-1-carboxylic acid (4), 2-hydroxyphenazine-1-carboxylic acid (5), 2-hydroxyphenazine (6), 2,8-dihydroxyphenazine (7), cyclo-Pro-Tyr (8), cyclo-Pro-Val (9), cyclo-Pro-Met (10), and WLIP (11) and characterized from the biocontrol strain Pseudomonas aurantiaca PB-St2. The structures of these compounds were deduced by 1D and 2D NMR spectroscopic and mass spectral data interpretation. Compounds 2, 4, and 7 showed moderate antibacterial activity against mycobacteria and other Gram-positive bacteria, while 4 was also found to exhibit cytotoxic and antifungal properties.
authors: Department of Biological Sciences, Forman Christian College University, Lahore, Pakistan. saminamehnaz@fccollege.edu.pk
authors: Samina
authors: S
authors: Mehnaz
authors: Rahman Shah Zaib
authors: RS
authors: Saleem
authors: Basit
authors: B
authors: Yameen
authors: Isabelle
authors: I
authors: Pianet
authors: Gregor
authors: G
authors: Schnakenburg
authors: Halina
authors: H
authors: Pietraszkiewicz
authors: Fred
authors: F
authors: Valeriote
authors: Michaele
authors: M
authors: Josten
authors: Hans-Georg
authors: HG
authors: Sahl
authors: Scott G
authors: SG
authors: Franzblau
authors: Harald
authors: H
authors: Gross
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D015394:Molecular Structure; D009159:Mycobacteriaceae / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011549:Pseudomonas / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D002264:Carboxylic Acids; D010619:Phenazines; C580645:lahorenoic acid A; C580646:lahorenoic acid B; C580647:lahorenoic acid C; C037165:1-phenazinecarboxylic acid