title: Effects of long-term feeding of α-glucosylhesperidin on the mechanical properties of rabbit femoral arteries.
abstract: Many people are sensitive to cold, resulting in poor blood circulation. There is evidence that hesperidin results in increased peripheral circulation and skin temperature. A transglycosylated hesperidin, α-glucosylhesperidin, is more bioabsorbable than hesperidin. In the present study, biomechanical studies were performed on the effects of long-term feeding of α-glucosylhesperidin on the contractile response (diameter response) and stiffness of femoral arteries excised from rabbits. Animals in the normal (non-treated), low, and high groups were fed 0, 150 and 4500 mg/day, respectively, of α-glucosylhesperidin for about 24 weeks. The feeding of α-glucosylhesperidin did not change arterial stiffness nor mean blood flow rate in the femoral artery; however, it increased mean aortic blood pressure and decreased arterial diameter at 100 mmHg in the high group. The diameter responses developed by 10-5 M of norepinephrine were significantly lower in the high and low groups than in non-treated group. This result indicates that, due to the long-term feeding of α-glucosylhesperidin, arterial contraction induced by the neurotransmitter of sympathetic nerves decreases. It was estimated that blood flow in such muscular arteries as the femoral artery is maintained at normal by α-glucosylhesperidin even under the conditions of autonomic imbalance and cold intolerance.
authors: Department of Biomedical Engineering, Okayama University of Science, Okayama, Japan. tnaiki@bme.ous.ac.jp
authors: Takeru
authors: T
authors: Naiki
authors: Yuki
authors: Y
authors: Kurose
authors: Kozaburo
authors: K
authors: Hayashi
authors: Hiroko
authors: H
authors: Takumi
authors: Takashi
authors: T
authors: Kometani
mesh_terms: D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects*; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D005263:Femoral Artery / Q000502:physiology*; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D006569:Hesperidin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D059289:Vascular Stiffness / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D005960:Glucosides; D014662:Vasoconstrictor Agents; C487382:glucosyl hesperidin; D006569:Hesperidin; D009638:Norepinephrine