title: Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management.
abstract: Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators.
authors: Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226-3548, US. Julie.Peterson@bcw.edu
authors: Julie A
authors: JA
authors: Peterson
authors: Janice G
authors: JG
authors: McFarland
authors: Brian R
authors: BR
authors: Curtis
authors: Richard H
authors: RH
authors: Aster
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018743:Perinatal Care / Q000379:methods; D017713:Platelet Transfusion / Q000379:methods; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy
chemical_list: D016824:Antigens, Human Platelet; D015415:Biomarkers
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