title: Nanostructured scaffolds for bone tissue engineering.
abstract: It has been demonstrated that nanostructured materials, compared with conventional materials, may promote greater amounts of specific protein interactions, thereby more efficiently stimulating new bone formation. It has also been indicated that, when features or ingredients of scaffolds are nanoscaled, a variety of interactions can be stimulated at the cellular level. Some of those interactions induce favorable cellular functions while others may leads to toxicity. This review presents the mechanism of interactions between nanoscaled materials and cells and focuses on the current research status of nanostructured scaffolds for bone tissue engineering. Firstly, the main requirements for bone tissue engineering scaffolds were discussed. Then, the mechanism by which nanoscaled materials promote new bone formation was explained, following which the current research status of main types of nanostructured scaffolds for bone tissue engineering was reviewed and discussed.
authors: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China. x.m.li@hotmail.com
authors: Xiaoming
authors: X
authors: Li
authors: Lu
authors: L
authors: Wang
authors: Yubo
authors: Y
authors: Fan
authors: Qingling
authors: Q
authors: Feng
authors: Fu-Zhai
authors: FZ
authors: Cui
authors: Fumio
authors: F
authors: Watari
mesh_terms: D000818:Animals; D001846:Bone Development; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes