title: Impaired timing and frequency discrimination in high-functioning autism spectrum disorders.
abstract: Individuals with autism spectrum disorders (ASD) frequently demonstrate preserved or enhanced frequency perception but impaired timing perception. The present study investigated the processing of spectral and temporal information in 12 adolescents with ASD and 15 age-matched controls. Participants completed two psychoacoustic tasks: one determined frequency difference limens, and the other determined gap detection thresholds. Results showed impaired frequency discrimination at the highest standard frequency in the ASD group but no overall difference between groups. However, when groups were defined by auditory hyper-sensitivity, a group difference arose. For the gap detection task, the ASD group demonstrated elevated thresholds. This supports previous research demonstrating a deficit in ASD in temporal perception and suggests a connection between hyper-sensitivity and frequency discrimination abilities.
authors: Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, 62-132 Center for Health Sciences Box 951624, Los Angeles, CA, 90095-1624, USA, bhatara@gmail.com.
authors: Anjali
authors: A
authors: Bhatara
authors: Talin
authors: T
authors: Babikian
authors: Elizabeth
authors: E
authors: Laugeson
authors: Raffi
authors: R
authors: Tachdjian
authors: Yvonne S
authors: YS
authors: Sininger
mesh_terms: D000293:Adolescent; D001307:Auditory Perception; D002659:Child Development Disorders, Pervasive / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D011571:Psychoacoustics; D013998:Time Perception
references: J Autism Dev Disord. 2004 Jun;34(3):279-84
references: 15264496
references: Am J Occup Ther. 1997 Jul-Aug;51(7):530-7
references: 9242859
references: Neuropsychologia. 1985;23(4):527-34
references: 2412182
references: Neurosci Lett. 2003 Mar 6;338(3):197-200
references: 12581830
references: J Autism Dev Disord. 2007 May;37(5):894-910
references: 17016677
references: J Am Acad Audiol. 2003 Nov;14(9):453-70
references: 14708835
references: Eur J Neurosci. 2005 Sep;22(6):1521-8
references: 16190905
references: Dev Sci. 2009 Jul;12(4):557-67
references: 19635083
references: Atten Percept Psychophys. 2012 Feb;74(2):430-45
references: 22076681
references: Brain. 2008 Sep;131(Pt 9):2479-88
references: 18669482
references: J Child Psychol Psychiatry. 1991 Nov;32(7):1107-22
references: 1787139
references: Neuroreport. 2003 Nov 14;14(16):2047-51
references: 14600495
references: J Acoust Soc Am. 2006 Dec;120(6):3929-45
references: 17225420
references: Cerebellum. 2005;4(4):279-89
references: 16321884
references: Am J Psychiatry. 2003 Nov;160(11):2057-60
references: 14594758
references: Brain Lang. 1982 Nov;17(2):287-300
references: 7159837
references: Am J Psychiatry. 2004 Nov;161(11):2117-20
references: 15514415
references: Brain Res Dev Brain Res. 2003 Sep 10;144(2):201-9
references: 12935917
references: Brain. 2012 Mar;135(Pt 3):949-60
references: 22350062
references: Br J Psychol. 2004 Aug;95(Pt 3):269-82
references: 15296535
references: Neuropsychologia. 2011 Feb;49(3):546-55
references: 21192958
references: J Autism Dev Disord. 2008 Jan;38(1):138-42
references: 17440802
references: Neuropsychologia. 2010 Jul;48(9):2465-75
references: 20433857
references: Neuroreport. 2005 Mar 15;16(4):329-32
references: 15729132
references: Autism. 2007 Mar;11(2):123-34
references: 17353213
references: Ear Hear. 2008 Apr;29(2):228-38
references: 18595187
references: Eur J Neurosci. 2001 Feb;13(3):628-32
references: 11168571
references: Trends Neurosci. 2006 Jul;29(7):382-390
references: 16806512
references: J Comp Physiol Psychol. 1963 Oct;56:899-902
references: 14050184
references: J Rehabil Res Dev. 2005 Nov-Dec;42(6):839-52
references: 16680621
references: J Child Psychol Psychiatry. 2006 Jun;47(6):591-601
references: 16712636
references: J Acoust Soc Am. 1988 Aug;84(2):566-72
references: 3170948
references: J Autism Dev Disord. 1985 Sep;15(3):285-302
references: 4030662
references: Dev Med Child Neurol. 2011 Nov;53(11):986-93
references: 21752020
references: J Autism Dev Disord. 2008 Aug;38(7):1230-40
references: 18064550
references: J Autism Dev Disord. 1989 Jun;19(2):255-69
references: 2745391
references: J Autism Dev Disord. 2006 Jul;36(5):665-75
references: 16639532
references: J Acoust Soc Am. 1995 Nov;98(5 Pt 1):2532-41
references: 7593935
references: Dev Sci. 2007 Nov;10(6):786-93
references: 17973796
references: J Autism Dev Disord. 2010 May;40(5):640-6
references: 19924521
references: Trends Cogn Sci. 2002 Jan 1;6(1):37-46
references: 11849614
references: J Child Psychol Psychiatry. 2003 May;44(4):543-51
references: 12751846
references: J Autism Dev Disord. 2009 May;39(5):742-50
references: 19148738
references: Am J Occup Ther. 2007 Mar-Apr;61(2):190-200
references: 17436841
references: Philos Trans R Soc Lond B Biol Sci. 2003 Feb 28;358(1430):375-86
references: 12639334
references: Lancet. 1977 Oct 8;2(8041):767
references: 71577
references: J Autism Dev Disord. 2003 Apr;33(2):163-7; discussion 169
references: 12757355
references: Acta Neurobiol Exp (Wars). 2004;64(3):295-301
references: 15283473
references: J Acoust Soc Am. 1994 Feb;95(2):980-91
references: 8132912
references: PLoS One. 2012;7(9):e44084
references: 22984462
references: Clin Neurophysiol. 2003 Sep;114(9):1671-80
references: 12948796
references: Cereb Cortex. 2009 Oct;19(10):2290-7
references: 19136454
references: Dev Sci. 2005 Jan;8(1):F1-F12
references: 15647058
references: J Acoust Soc Am. 1984 Apr;75(4):1195-200
references: 6725769
references: Brain Res Brain Res Rev. 2003 Dec;43(3):231-46
references: 14629926
references: Child Neuropsychol. 2004 Dec;10(4):223-47
references: 15621847
references: Psychon Bull Rev. 1995 Dec;2(4):460-93
references: 24203785
references: Curr Opin Neurobiol. 2003 Apr;13(2):250-5
references: 12744981
references: Brain Res. 2005 Dec 20;1066(1-2):147-57
references: 16325159
references: Dev Med Child Neurol. 2012 Jan;54(1):23-9
references: 22142282
references: Lancet. 1993 Oct 9;342(8876):923-4
references: 8105178
references: Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5567-72
references: 12702776
references: Laterality. 2012;17(2):129-49
references: 22385138
references: Dev Sci. 2008 Jan;11(1):109-21
references: 18171373
references: Br J Dev Psychol. 2005 Nov;23(4):543-58
references: 21214596
references: Front Integr Neurosci. 2011 Jan 05;4:129
references: 21258617
references: Neuropsychologia. 2009 Nov;47(13):2850-8
references: 19545576
references: Psychophysiology. 2004 May;41(3):341-9
references: 15102118
references: Am J Ment Retard. 2007 Jul;112(4):233-45
references: 17559291
references: J Autism Dev Disord. 2011 Jun;41(6):705-14
references: 20827502
references: Q J Exp Psychol (Hove). 2012;65(11):2093-107
references: 22800511
references: Child Dev. 1986 Dec;57(6):1440-53
references: 3802970
references: J Autism Dev Disord. 2007 Mar;37(3):481-90
references: 16897381
references: Nat Neurosci. 1998 Sep;1(5):422-7
references: 10196534
references: J Acoust Soc Am. 2009 Oct;126(4):1926-40
references: 19813805
references: J Autism Dev Disord. 1993 Mar;23(1):15-35
references: 8463195
references: Cogn Neuropsychol. 2008 Sep;25(6):771-82
references: 18720290
references: Pro Fono. 2008 Oct-Dec;20(4):279-84
references: 19142473
references: Brain. 2012 Mar;135(Pt 3):656-77
references: 21921020
references: Ear Hear. 2012 May-Jun;33(3):411-20
references: 22237163
references: Annu Rev Neurosci. 2004;27:307-40
references: 15217335
references: Cortex. 1979 Mar;15(1):73-81
references: 446048
references: Neuroreport. 1998 Jan 26;9(2):337-40
references: 9507979
references: Science. 1996 Jan 5;271(5245):77-81
references: 8539603
references: J Acoust Soc Am. 1983 Aug;74(2):467-73
references: 6619424
references: J Autism Dev Disord. 1987 Dec;17(4):585-94
references: 3680158
references: Autism. 2008 Mar;12(2):203-19
references: 18308768
references: J Acoust Soc Am. 1998 Oct;104(4):2467-76
references: 10491708
references: J Cogn Neurosci. 2003 Feb 15;15(2):226-35
references: 12676060
references: J Exp Child Psychol. 1989 Oct;48(2):270-92
references: 2794857
references: Clin Neurophysiol. 1999 Nov;110(11):1927-34
references: 10576489
references: Neurosci Lett. 2005 Sep 30;386(2):82-7
references: 16046066
references: J Acoust Soc Am. 1989 Nov;86(5):1747-55
references: 2808923
references: Science. 1996 Jan 5;271(5245):81-4
references: 8539604
references: Neuroreport. 2001 Nov 16;12(16):3603-7
references: 11733720
references: J Neurosci. 2010 Apr 7;30(14):4922-6
references: 20371812
references: Brain Dev. 2003 Apr;25(3):166-72
references: 12689694
references: J Acoust Soc Am. 1983 Oct;74(4):1190-9
references: 6643841
references: Neuropsychologia. 1971 Mar;9(1):97-113
references: 5146491
references: Biol Psychiatry. 1995 Aug 1;38(3):150-65
references: 7578658
references: Can J Psychol. 1972 Jun;26(2):111-6
references: 5035120
references: J Child Psychol Psychiatry. 2004 Sep;45(6):1107-14
references: 15257667
references: Ear Hear. 2006 Jun;27(3):299-312
references: 16672798
references: Trends Cogn Sci. 1997 May;1(2):56-61
references: 21223864
references: J Acoust Soc Am. 1981 Feb;69(2):568-74
references: 7462479
references: Nat Neurosci. 2001 Jun;4(6):633-7
references: 11369945
references: J Speech Lang Hear Res. 1999 Dec;42(6):1295-310
references: 10599613
references: Cereb Cortex. 2001 Oct;11(10):946-53
references: 11549617
references: Psychophysiology. 2002 Sep;39(5):577-84
references: 12236323
references: PLoS One. 2012;7(5):e37961
references: 22666425
references: Electroencephalogr Clin Neurophysiol. 1985 Dec;61(6):491-501
references: 2415323
references: Neuron. 2002 Nov 14;36(4):767-76
references: 12441063
references: J Autism Dev Disord. 2003 Dec;33(6):631-42
references: 14714932
references: J Neurosci. 2009 Jan 7;29(1):61-9
references: 19129385
references: Ann N Y Acad Sci. 2001 Jun;930:117-32
references: 11458823
references: J Int Neuropsychol Soc. 2000 Nov;6(7):752-9
references: 11105465
references: Philos Trans R Soc Lond B Biol Sci. 2008 Mar 12;363(1493):1087-104
references: 17890188
references: Neuropsychologia. 2012 Jun;50(7):1235-51
references: 22349444
references: J Child Psychol Psychiatry. 2005 May;46(5):514-23
references: 15845131
references: J Speech Hear Res. 1975 Dec;18(4):686-706
references: 1207100
references: Curr Opin Neurobiol. 2007 Feb;17(1):103-11
references: 17275283
references: Psychol Bull. 1984 Mar;95(2):258-81
references: 6544434
references: Autism. 2006 Sep;10(5):480-94
references: 16940314
references: Clin Neurophysiol. 2008 Aug;119(8):1720-1731
references: 18558508
references: Int J Psychophysiol. 2003 Dec;51(1):17-25
references: 14629919
references: Nat Rev Neurosci. 2005 Oct;6(10):755-65
references: 16163383
references: J Autism Dev Disord. 2006 Apr;36(3):343-50
references: 16552625
references: J Acoust Soc Am. 1969 Dec;46(6):1468-72
references: 5361516
references: J Acoust Soc Am. 1974 Mar;55(3):653-9
references: 4819867
references: Hear Res. 2004 Dec;198(1-2):87-92
references: 15617227
references: J Autism Dev Disord. 2009 Jul;39(7):1087-91
references: 19283461
references: J Autism Dev Disord. 1999 Oct;29(5):349-57
references: 10587881
references: J Acoust Soc Am. 2000 Sep;108(3 Pt 1):1252-63
references: 11008825
references: Neuropsychologia. 2008 Jan 31;46(2):632-9
references: 17959204
references: Neuropsychologia. 1977;15(6):833-5
references: 600378
references: Biol Psychol. 2007 Apr;75(1):109-14
references: 17257732
references: Appl Psychophysiol Biofeedback. 2013 Mar;38(1):17-28
references: 22903518
references: J Acoust Soc Am. 1992 May;91(5):2881-93
references: 1629481
references: J Autism Dev Disord. 2003 Feb;33(1):3-13
references: 12708575
references: J Acoust Soc Am. 2001 Oct;110(4):2183-90
references: 11681394