title: Current management strategies for verrucous hyperkeratosis and verrucous carcinoma.
abstract: Proliferative verrucous leukoplakia, a lesion of unknown origin with no strictly defined diagnostic criteria, is worthy of great clinical concern and scrutiny. Treatment options vary, with no consensus regarding the most efficient and effective strategy. Further complicating the unusual biology and behavior of this lesion is its usual multifocal presentation and progression, with lifelong vigilance required after treatment. Verrucous carcinoma is a progressive lesion with high recurrence and 5-year survival rates. Surgery remains the preferred treatment. Further investigation into the combination of surgery and antiviral agents may bring additional improvement in patient care.
authors: Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Hospital, 600 North Wolfe Street, Sheikh Zayed Tower, Baltimore, MD 21287, USA.
authors: James J
authors: JJ
authors: Sciubba
authors: Joseph I
authors: JI
authors: Helman
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D018289:Carcinoma, Verrucous / Q000601:surgery*; D018450:Disease Progression; D006801:Humans; D007972:Leukoplakia, Oral / Q000601:surgery*; D009062:Mouth Neoplasms / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D015996:Survival Rate
chemical_list: D000998:Antiviral Agents