title: Supramolecular nanostructures formed by anticancer drug assembly.
abstract: We report here a supramolecular strategy to directly assemble the small molecular hydrophobic anticancer drug camptothecin (CPT) into discrete, stable, well-defined nanostructures with a high and quantitative drug loading. Depending on the number of CPTs in the molecular design, the resulting nanostructures can be either nanofibers or nanotubes, and have a fixed CPT loading content ranging from 23% to 38%. We found that formation of nanostructures provides protection for both the CPT drug and the biodegradable linker from the external environment and thus offers a mechanism for controlled release of CPT. Under tumor-relevant conditions, these drug nanostructures can release the bioactive form of CPT and show in vitro efficacy against a number of cancer cell lines. This strategy can be extended to construct nanostructures of other types of anticancer drugs and thus presents new opportunities for the development of self-delivering drugs for cancer therapeutics.
authors: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors: Andrew G
authors: AG
authors: Cheetham
authors: Pengcheng
authors: P
authors: Zhang
authors: Yi-an
authors: YA
authors: Lin
authors: Lye Lin
authors: LL
authors: Lock
authors: Honggang
authors: H
authors: Cui
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D002166:Camptothecin / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures
chemical_list: D000970:Antineoplastic Agents; D002166:Camptothecin
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