title: Outcomes of congenital diaphragmatic hernia in the modern era of management.
abstract: OBJECTIVE
  To identify clinical factors associated with pulmonary hypertension (PH) and mortality in patients with congenital diaphragmatic hernia (CDH).
  
  
  METHODS
  A prospective cohort of neonates with a diaphragm defect identified at 1 of 7 collaborating medical centers was studied. Echocardiograms were performed at 1 month and 3 months of age and analyzed at a central core by 2 cardiologists independently. Degree of PH and survival were tested for association with clinical variables using Fischer exact test, χ(2), and regression analysis.
  
  
  RESULTS
  Two hundred twenty patients met inclusion criteria. Worse PH measured at 1 month of life was associated with higher mortality. Other factors associated with mortality were need for extracorporeal membrane oxygenation, patients inborn at the treating center, and patients with a prenatal diagnosis of CDH. Interestingly, patients with right sided CDH did not have worse outcomes.
  
  
  CONCLUSIONS
  Severity of PH is associated with mortality in CDH. Other factors associated with mortality were birth weight, gestational age at birth, inborn status, and need for extracorporeal membrane oxygenation.
authors: Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA.
authors: Julia
authors: J
authors: Wynn
authors: Usha
authors: U
authors: Krishnan
authors: Gudrun
authors: G
authors: Aspelund
authors: Yuan
authors: Y
authors: Zhang
authors: Jimmy
authors: J
authors: Duong
authors: Charles J H
authors: CJ
authors: Stolar
authors: Eunice
authors: E
authors: Hahn
authors: John
authors: J
authors: Pietsch
authors: Dai
authors: D
authors: Chung
authors: Donald
authors: D
authors: Moore
authors: Eric
authors: E
authors: Austin
authors: George
authors: G
authors: Mychaliska
authors: Robert
authors: R
authors: Gajarski
authors: Yen-Lim
authors: YL
authors: Foong
authors: Erik
authors: E
authors: Michelfelder
authors: Douglas
authors: D
authors: Potolka
authors: Brian
authors: B
authors: Bucher
authors: Brad
authors: B
authors: Warner
authors: Mark
authors: M
authors: Grady
authors: Ken
authors: K
authors: Azarow
authors: Scott E
authors: SE
authors: Fletcher
authors: Shelby
authors: S
authors: Kutty
authors: Jeff
authors: J
authors: Delaney
authors: Timothy
authors: T
authors: Crombleholme
authors: Erika
authors: E
authors: Rosenzweig
authors: Wendy
authors: W
authors: Chung
authors: Marc S
authors: MS
authors: Arkovitz
mesh_terms: D005260:Female; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000401:mortality; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000401:mortality*; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
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