title: [Acute renal failure and severe malaria in Congolese children living in Kinshasa, Democratic Republic of Congo].
abstract: BACKGROUND
  Data on acute renal failure in complicated malaria in children in the Democratic Republic of Congo are sparse. The objective of this study was to document the profile of acute renal failure in severe malaria in admitted patients in pediatric hospitals from Kinshasa.
  
  
  METHODS
  A prospective cohort study was conducted from January 2008 to December 2008 in children admitted in emergency units of five hospitals in Kinshasa for severe malaria.
  
  
  RESULTS
  In our series, 378 children with severe malaria were included. There were 226 boys and 152 girls (sex ratio 1.49). One hundred and ninety four (194) of these patients were under 5 years old. Acute renal failure was observed in 89 children (23.6%) and 87 of them had blackwater fever (BWF). This form of severe malaria was predominant in children older than 5 years. Quinine was the commonest antimalarial drug involved in the genesis of BWF. Dialysis was indicated in 23 children (24.0%) and was effective (acute peritoneal dialysis) in 21 patients. The death rate in children with ARF was 12.6% (n=87). Recovery of renal function was obtained by conservative treatment in the remained group.
  
  
  CONCLUSIONS
  This study confirmed the emergence of BWF in seemed protected autochthon children older than 5 years. BWF remained the leading cause of acute renal failure in complicated malaria among Congolese children in Kinshasa.
authors: Unité de Néphrologie Pédiatrique, Département de Pédiatrie, Cliniques Universitaires de Kinshasa, Faculté de Médecine, Université de Kinshasa, BP 123 Kinshasa XI, République démocratique du Congo.
authors: Thomas Sengua
authors: TS
authors: Kunuanunua
authors: Célestin Ndosimao
authors: CN
authors: Nsibu
authors: Jean-Lambert
authors: JL
authors: Gini-Ehungu
authors: Joseph Mabiala
authors: JM
authors: Bodi
authors: Pépé Mfutu
authors: PM
authors: Ekulu
authors: Hypolite
authors: H
authors: Situakibanza
authors: Nazaire Mangani
authors: NM
authors: Nseka
authors: Kumbundu
authors: K
authors: Magoga
authors: Michel Ntetani
authors: MN
authors: Aloni
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000453:epidemiology*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015023:Democratic Republic of the Congo / Q000453:epidemiology; D004636:Emergency Service, Hospital; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008288:Malaria / Q000150:complications / Q000453:epidemiology*; D008297:Male; D011446:Prospective Studies