title: Transdermal delivery of human epidermal growth factor facilitated by a peptide chaperon.
abstract: Peptide chaperon TD1 was discovered to facilitate several proteins' transdermal delivery via topical co-administration. To design a practical, safe system for advanced transdermal peptide, a novel method was carried out. Human epidermal growth factor (hEGF) was selected as the model biological agent and a fusion protein: TD1-hEGF was designed. Study showed that TD1-hEGF not only had the similar bioactivity with native hEGF, but also possessed considerable higher transdermal ability than hEGF and a co-administration of TD1 and hEGF. These results provided convincing evidence for the advantages of TD1-hEGF in cosmetic and medical applications. Moreover, the fusion pattern between the cargoes and TD1 offered a new approach to facilitate other hydrophilic drugs' transdermal delivery for therapeutic application.
authors: School of Life Science, University of Science and Technology of China, Hefei 230026, PR China.
authors: Ren-Quan
authors: RQ
authors: Ruan
authors: Shan-Shan
authors: SS
authors: Wang
authors: Chang-Li
authors: CL
authors: Wang
authors: Li
authors: L
authors: Zhang
authors: Yun-Jiao
authors: YJ
authors: Zhang
authors: Wei
authors: W
authors: Zhou
authors: Wei-Ping
authors: WP
authors: Ding
authors: Pei-Pei
authors: PP
authors: Jin
authors: Peng-Fei
authors: PF
authors: Wei
authors: Na
authors: N
authors: Man
authors: Long-Ping
authors: LP
authors: Wen
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D041702:BALB 3T3 Cells; D049109:Cell Proliferation; D002478:Cells, Cultured; D016503:Drug Delivery Systems; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018832:Molecular Chaperones / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D009842:Oligopeptides / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
chemical_list: D018832:Molecular Chaperones; D009842:Oligopeptides; D004815:Epidermal Growth Factor