title: A randomized, open-label clinical trial using optical coherence tomography to compare two sirolimus-eluting stents, one with a biodegradable polymer and the other with a permanent polymer.
abstract: Intimal hyperplasia appears to differ after implanting a drug-eluting stent (DES) with a biodegradable or a permanent polymer. The aim of the present study was to compare biodegradable with permanent polymer DES, since the available data are limited. One hundred patients with de novo coronary artery stenosis were included in this study. The patients were classified into 2 groups: DES with a biodegradable polymer (n=50) and DES with a permanent polymer (n=50). Optical coherence tomography (OCT) examination was performed before and after stent implantation. A follow‑up OCT, performed 1 year after stent implantation, compared the morphologies of intimal hyperplasia in the 2 groups. The frequencies of uncovered stent struts (2.27 vs. 1.87%, P=0.145) and stent strut malapposition (1.9 vs. 2.02%, P=0.655) upon the first-year follow-up were not significantly different. Average neointimal thickness was lower in the biodegradable compared with the permanent polymer group (106.12±80.65 vs. 181.20±146.96 µm, P<0.001). The frequencies of neointimal thickness <100 µm were significantly higher in the biodegradable compared with the permanent polymer group (62.1 vs. 35.9%, P<0.001). The average intimal thickness was also lower in the biodegradable compared with the permanent polymer group (57.7±24.6 vs. 67.6±22.4 µm, P<0.001). In conclusion, biodegradable polymer DES resulted in significantly lower intimal hyperplasia and had well-proportioned intimal coverage compared with permanent polymer DES.
authors: Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors: Feng
authors: F
authors: Tian
authors: Yundai
authors: Y
authors: Chen
authors: Changfu
authors: C
authors: Liu
authors: Qinhua
authors: Q
authors: Jin
authors: Lian
authors: L
authors: Chen
authors: Zhijun
authors: Z
authors: Sun
authors: Hongbin
authors: H
authors: Liu
authors: Jun
authors: J
authors: Guo
authors: Luyue
authors: L
authors: Gai
mesh_terms: D000368:Aged; D063566:Biodegradable Plastics / Q000627:therapeutic use*; D023921:Coronary Stenosis / Q000473:pathology / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011108:Polymers / Q000627:therapeutic use*; D020123:Sirolimus / Q000008:administration & dosage*; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology
chemical_list: D063566:Biodegradable Plastics; D011108:Polymers; D020123:Sirolimus