title: Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation.
abstract: Misregulated innate immune signaling and cell death form the basis of much human disease pathogenesis. Inhibitor of apoptosis (IAP) protein family members are frequently overexpressed in cancer and contribute to tumor cell survival, chemo-resistance, disease progression, and poor prognosis. Although best known for their ability to regulate caspases, IAPs also influence ubiquitin (Ub)-dependent pathways that modulate innate immune signaling via activation of nuclear factor κB (NF-κB). Recent research into IAP biology has unearthed unexpected roles for this group of proteins. In addition, the advances in our understanding of the molecular mechanisms that IAPs use to regulate cell death and innate immune responses have provided new insights into disease states and suggested novel intervention strategies. Here we review the functions assigned to those IAP proteins that act at the intersection of cell death regulation and inflammatory signaling.
authors: The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. J.Silke@latrobe.edu.au
authors: John
authors: J
authors: Silke
authors: Pascal
authors: P
authors: Meier
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D001665:Binding Sites; D002470:Cell Survival; D007113:Immunity, Innate; D007249:Inflammation / Q000378:metabolism*; D051034:Inhibitor of Apoptosis Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D048069:Tumor Necrosis Factors / Q000378:metabolism
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D048069:Tumor Necrosis Factors
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