title: A meta-analysis about the association between -1082G/A and -819C/T polymorphisms of IL-10 gene and risk of type 2 diabetes.
abstract: The present meta-analysis was conducted to investigate the association between the -1082G/A and -819C/T polymorphisms of the IL-10 gene and risk of type 2 diabetes mellitus (T2DM). Relevant articles were identified by searching PubMed, Embase, and Web of Science. Pooled odds ratios (ORs) were used to assess the strength of the association between target polymorphisms and the risk of T2DM. Significant associations between the -1082G/A polymorphism and T2DM were found for the allele contrast (OR=0.90, 95% CI: [0.83, 0.98], P=0.02), homozygote contrast (OR=0.82, 95% CI: [0.69, 0.97], P=0.02), and recessive genetic model (OR=0.85, 95% CI: [0.74, 0.96], P=0.01). However, no significant association was found for the dominant genetic model (OR=0.91, 95% CI: [0.80, 1.05], P=0.08). The association between -819C/T polymorphism and T2DM was significant for the allele contrast (OR=0.73, 95% CI: [0.64, 0.84], P<0.01); however, no significant associations were found for -819C/T in the homozygote contrast (OR=1.01, 95% CI: [0.38, 2.67], P=0.99), dominant genetic model (OR=0.94, 95% CI: [0.50, 1.77], P=0.86), and recessive genetic model (OR=0.92, 95% CI: [0.50, 1.68], P=0.78). No significant publication bias was detected. This meta-analysis suggests that allele A of -1082G/A and allele C of -819C/T in the IL-10 gene have potentially protective effects in terms of risk of T2DM.
authors: School of Public Health and Health Management, Chongqing Medical University, Chongqing, China.
authors: Fan
authors: F
authors: Zhang
authors: Yuan
authors: Y
authors: Yang
authors: Han
authors: H
authors: Lei
authors: Jingfu
authors: J
authors: Qiu
authors: Yang
authors: Y
authors: Wang
authors: Dayi
authors: D
authors: Hu
authors: Laura
authors: L
authors: Skrip
authors: Fangchun
authors: F
authors: Chen
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D016753:Interleukin-10