title: Molecular classification of hepatocellular adenomas.
abstract: Hepatocellular adenomas (HCAs) are benign tumors developed in normal liver most frequently in women before menopause. HCAs lead to diagnostic pitfalls and several difficulties to assess the risk of malignant transformation in these young patients. Recent advances in basic knowledge have revealed a molecular classification related to risk factors, pathological features, and risk of transformation in hepatocellular carcinoma. Three major molecular pathways have been identified altered in specific HCA subgroups that are defined by either (1) inactivation of hepatocyte nuclear factor 1A (HNF1A) transcription factor, (2) activation of the WNT/β-catenin by CTNNB1 mutations, or (3) activation of the IL6/STAT3 pathway by somatic mutation of IL6ST, GNAS, or STAT3. Here, we will review the different molecular classes of HCA.
authors: Inserm UMR-674, Génomique Fonctionnelle des Tumeurs Solides, IUH, 75010 Paris, France ; Labex Immuno-Oncology, Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, 75005 Paris, France.
authors: Jean Charles
authors: JC
authors: Nault
authors: Jessica
authors: J
authors: Zucman Rossi
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