title: Dedifferentiated chondrosarcoma of the cervical spine: a case report.
abstract: Dedifferentiated chondrosarcoma (DDCS) is a rare and aggressive bone tumor with poor prognosis. Primary DDCS of the mobile spine is extremely rare, particularly in the cervical spine. We herein describe a first case of cervical DDCS in an 81-year-old male presenting with a slowly growing mass. Radiographs showed an expansion of the cortical contour of the C2 lamina and a soft tissue mass with punctate calcification. Magnetic resonance imaging demonstrated a lobulated lesion expanding over the entire lamina and pedicles of C2 with the tumor protuberant to the adjacent soft tissue. A complete tumor resection was performed. Histologically, the majority of the tumor was a low-grade chondrosarcoma component. However, atypical spindle cells that had proliferated in a fascicular pattern with a collagenous stroma, mimicking fibrosarcoma, were focally observed without a transitional zone, and these features confirmed that the tumor was DDCS.
authors: Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ymatsu@ortho.med.kyushu-u.ac.jp
authors: Yoshihiro
authors: Y
authors: Matsumoto
authors: Yusuke
authors: Y
authors: Takahashi
authors: Katsumi
authors: K
authors: Harimaya
authors: Takeshi
authors: T
authors: Nakagawa
authors: Kenichi
authors: K
authors: Kawaguchi
authors: Seiji
authors: S
authors: Okada
authors: Mitsumasa
authors: M
authors: Hayashida
authors: Toshio
authors: T
authors: Doi
authors: Akio
authors: A
authors: Sakamoto
authors: Tomoya
authors: T
authors: Matsunobu
authors: Yoshinao
authors: Y
authors: Oda
authors: Yukihide
authors: Y
authors: Iwamoto
mesh_terms: D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery; D002574:Cervical Vertebrae / Q000473:pathology* / Q000601:surgery; D002813:Chondrosarcoma / Q000473:pathology* / Q000601:surgery; D005354:Fibrosarcoma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D060787:Neoplasm Grading; D011379:Prognosis; D013122:Spinal Diseases / Q000473:pathology* / Q000601:surgery
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