title: Synergistic effects of taurine and L-arginine on attenuating insulin resistance hypertension.
abstract: To elucidate the synergistic effects of taurine and L-arginine on hypertension, 25% fructose were administered to male Wistar rats for 3 months to establish insulin resistance hypertensive models. Rats with the systolic blood pressure (SBP) higher than 150 mmHg were considered as model rats. Forty-two model rats were randomly divided into six groups and administered with 3% taurine, 2.7% taurine + 0.3% L-arginine, 2.1% taurine +  0.9% L-arginine, 1.5% taurine + 1.5% L-arginine and 3% L-arginine in drinking water respectively. The results showed that coadministration of taurine (1.5%) and L-arginine (1.5%) could bring the levels of SBP, blood glucose, and insulin down to normal levels after 4 weeks. The thickness of blood vessels increased significantly in model group, which could be reversed by taurine and L-arginine. Serum NO, cGMP, and ET levels could return to normal levels. These data indicated that both taurine and L-arginine could ameliorate vascular remodeling and showed obvious antihypertensive effects, and taurine (1.5%) and L-arginine (1.5%) in the drinking water showed a better result in the cure of hypertension.
authors: College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, People's Republic of China.
authors: Ying
authors: Y
authors: Feng
authors: Jitao
authors: J
authors: Li
authors: Jiancheng
authors: J
authors: Yang
authors: Qunhui
authors: Q
authors: Yang
authors: Qiufeng
authors: Q
authors: Lv
authors: Yongchao
authors: Y
authors: Gao
authors: Jianmin
authors: J
authors: Hu
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001120:Arginine / Q000494:pharmacology / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D006152:Cyclic GMP / Q000097:blood; D004357:Drug Synergism; D016232:Endothelins / Q000097:blood; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013599:Systole / Q000187:drug effects; D013654:Taurine / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D001786:Blood Glucose; D016232:Endothelins; D007328:Insulin; D013654:Taurine; D009569:Nitric Oxide; D001120:Arginine; D006152:Cyclic GMP