title: Fabrication of a new electrochemical sensor based on a new nano-molecularly imprinted polymer for highly selective and sensitive determination of tramadol in human urine samples.
abstract: A new nano-molecularly imprinted polymer bead was synthesized and applied to the fabrication of a chemically modified carbon paste electrode. Nano-molecularly imprinted polymer with molecular recognition capacity was made-up by using SiO2@Fe3O4 as the core and the supporting material. The electrode was applied to the simple, rapid, highly selective and sensitive determination of tramadol using square wave voltammetry. The molecularly imprinted polymer and multi-walled carbon nanotubes modified carbon paste electrode was prepared by incorporating the synthesized nano-MIP and multi-walled carbon nanotubes in carbon paste electrode. The limit of detection and the linear range were found to be 0.004 and 0.01 to 20 μmol L(-1) of tramadol, respectively. The effects of potentially interfering substances on the determination of this compound were investigated. And it was found that the electrode is highly selective. The proposed chemically modified carbon paste electrode was used for the determination of tramadol in infected and healthy human urine and pharmaceutical samples.
authors: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran. afkhami@basu.ac.ir
authors: Abbas
authors: A
authors: Afkhami
authors: Hamed
authors: H
authors: Ghaedi
authors: Tayyebeh
authors: T
authors: Madrakian
authors: Mazaher
authors: M
authors: Ahmadi
authors: Hedye
authors: H
authors: Mahmood-Kashani
mesh_terms: D000701:Analgesics, Opioid / Q000032:analysis* / Q000652:urine; D055664:Electrochemical Techniques / Q000191:economics / Q000295:instrumentation*; D004566:Electrodes; D006801:Humans; D057230:Limit of Detection; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D054802:Molecular Imprinting; D037742:Nanotubes, Carbon / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013997:Time Factors; D014147:Tramadol / Q000032:analysis* / Q000652:urine
chemical_list: D000701:Analgesics, Opioid; D058185:Magnetite Nanoparticles; D037742:Nanotubes, Carbon; D004364:Pharmaceutical Preparations; D011108:Polymers; D014147:Tramadol; D012822:Silicon Dioxide