title: Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives.
abstract: A series of indazolo[4,3-gh]isoquinolinones derivatives have been synthesized to decrease cardiotoxic side effects in comparison to Mitoxantrone. The antiproliferative effects of different side chains were investigated and tested on at least four different cell lines of cervix, ovarian, CNS, NSCLC (non-small-cell lung cancer) and colon carcinoma. In addition to antiproliferative activities, influence on cell cycle and intercalation behavior have been tested.
authors: Department of Drug and Natural Product Synthesis, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
authors: Manochehr
authors: M
authors: Shahabi
authors: Eva
authors: E
authors: Schirmer
authors: Karem
authors: K
authors: Shanab
authors: Theerachart
authors: T
authors: Leepasert
authors: Jana
authors: J
authors: Ruzicka
authors: Wolfgang
authors: W
authors: Holzer
authors: Helmut
authors: H
authors: Spreitzer
authors: Babette
authors: B
authors: Aicher
authors: Peter
authors: P
authors: Schmidt
authors: Lars
authors: L
authors: Blumenstein
authors: Gilbert
authors: G
authors: Müller
authors: Eckhard
authors: E
authors: Günther
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007191:Indazoles / Q000737:chemistry*; D008942:Mitoxantrone / Q000737:chemistry / Q000633:toxicity; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D059807:S Phase Cell Cycle Checkpoints / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007191:Indazoles; D015363:Quinolones; D004247:DNA; D008942:Mitoxantrone