title: Hamster-adapted Sin Nombre virus causes disseminated infection and efficiently replicates in pulmonary endothelial cells without signs of disease.
abstract: To date, a laboratory animal model for the study of Sin Nombre virus (SNV) infection or associated disease has not been described. Unlike infection with Andes virus, which causes lethal hantavirus pulmonary syndrome (HPS)-like disease in hamsters, SNV infection is short-lived, with no viremia and little dissemination. Here we investigated the effect of passaging SNV in hamsters. We found that a host-adapted SNV achieves prolonged and disseminated infection in hamsters, including efficient replication in pulmonary endothelial cells, albeit without signs of disease.
authors: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA. safronetzd@niaid.nih.gov
authors: David
authors: D
authors: Safronetz
authors: Joseph
authors: J
authors: Prescott
authors: Elaine
authors: E
authors: Haddock
authors: Dana P
authors: DP
authors: Scott
authors: Heinz
authors: H
authors: Feldmann
authors: Hideki
authors: H
authors: Ebihara
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D058070:Asymptomatic Diseases; D006224:Cricetinae; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000821:virology*; D018804:Hantavirus Pulmonary Syndrome / Q000662:veterinary* / Q000821:virology; D029261:Sin Nombre virus / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity*; D014779:Virus Replication
references: Antiviral Res. 2012 Sep;95(3):282-92
references: 22705798
references: PLoS Pathog. 2011 Dec;7(12):e1002426
references: 22194683
references: Virus Res. 2011 Sep;160(1-2):108-19
references: 21672562
references: J Infect Dis. 2002 Nov 15;186(10):1390-5
references: 12404153
references: Am J Trop Med Hyg. 2008 Apr;78(4):669-74
references: 18385367
references: Antiviral Res. 2008 Apr;78(1):162-9
references: 18093668
references: Virology. 2004 Aug 15;326(1):130-9
references: 15262501
references: J Mol Diagn. 2012 Jan;14(1):22-9
references: 22166544
references: Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10578-83
references: 10973478
references: Virus Res. 2011 Dec;162(1-2):138-47
references: 21945215
references: J Gen Virol. 2007 Feb;88(Pt 2):493-505
references: 17251568
references: Virology. 2001 Oct 10;289(1):6-14
references: 11601912
references: J Virol. 2007 Jul;81(14):7449-62
references: 17475651
references: Arch Virol. 2012 Nov;157(11):2227-33
references: 22821183