title: Microbiology: EHEC downregulates virulence in response to intestinal fucose.
abstract: Recent work has revealed that enterohaemorrhagic Escherichia coli encodes a two-component system, termed FusKR, which responds to fucose and represses expression of virulence genes. Furthermore, a representative member of the microbiota appears to cleave fucose from host glycans, indicating that the microbiota and EHEC may act in concert to suppress virulence gene expression.
authors: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
authors: Kristie M
authors: KM
authors: Keeney
authors: B Brett
authors: BB
authors: Finlay
mesh_terms: D041963:Bacteroidetes / Q000378:metabolism*; D015536:Down-Regulation; D054324:Enterohemorrhagic Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D005643:Fucose / Q000378:metabolism*; D005798:Genes, Bacterial; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D010750:Phosphoproteins / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D014774:Virulence
chemical_list: D029968:Escherichia coli Proteins; C457340:LEE protein, E coli; D010750:Phosphoproteins; D005643:Fucose; C577921:FusK protein, E coli; D011494:Protein Kinases