title: Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.
abstract: After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8+ effector cells. Long-lived memory CD8+ cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8+ effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8+ T cell immunity.
authors: Division of Biological Sciences, University of California San Diego, La Jolla, California, USA.
authors: J Adam
authors: JA
authors: Best
authors: David A
authors: DA
authors: Blair
authors: Jamie
authors: J
authors: Knell
authors: Edward
authors: E
authors: Yang
authors: Viveka
authors: V
authors: Mayya
authors: Andrew
authors: A
authors: Doedens
authors: Michael L
authors: ML
authors: Dustin
authors: Ananda W
authors: AW
authors: Goldrath
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D007156:Immunologic Memory / Q000235:genetics* / Q000276:immunology*; D007239:Infections / Q000235:genetics* / Q000276:immunology*; D008297:Male; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D011948:Receptors, Antigen, T-Cell
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