title: Calcium channels and short-term synaptic plasticity.
abstract: Voltage-gated Ca(2+) channels in presynaptic nerve terminals initiate neurotransmitter release in response to depolarization by action potentials from the nerve axon. The strength of synaptic transmission is dependent on the third to fourth power of Ca(2+) entry, placing the Ca(2+) channels in a unique position for regulation of synaptic strength. Short-term synaptic plasticity regulates the strength of neurotransmission through facilitation and depression on the millisecond time scale and plays a key role in encoding information in the nervous system. Ca(V)2.1 channels are the major source of Ca(2+) entry for neurotransmission in the central nervous system. They are tightly regulated by Ca(2+), calmodulin, and related Ca(2+) sensor proteins, which cause facilitation and inactivation of channel activity. Emerging evidence reviewed here points to this mode of regulation of Ca(V)2.1 channels as a major contributor to short-term synaptic plasticity of neurotransmission and its diversity among synapses.
authors: Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.
authors: William A
authors: WA
authors: Catterall
authors: Karina
authors: K
authors: Leal
authors: Evanthia
authors: E
authors: Nanou
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020864:Calcium Channels, N-Type / Q000235:genetics / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D013569:Synapses / Q000235:genetics*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D002118:Calcium; D020864:Calcium Channels, N-Type; D002147:Calmodulin; D009419:Nerve Tissue Proteins
references: Nature. 1999 May 13;399(6732):155-9
references: 10335845
references: Trends Neurosci. 2003 Aug;26(8):413-22
references: 12900172
references: Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2813-8
references: 12601155
references: J Physiol. 2007 Nov 1;584(Pt 3):835-51
references: 17823210
references: Neuron. 2000 Jun;26(3):683-94
references: 10896163
references: Structure. 2008 Oct 8;16(10):1455-67
references: 18940602
references: Nature. 2004 Jun 10;429(6992):675-80
references: 15170217
references: Trends Neurosci. 2002 Apr;25(4):206-12
references: 11998689
references: Nature. 1996 Nov 14;384(6605):170-2
references: 8906792
references: J Physiol. 1954 Jun 28;124(3):574-85
references: 13175200
references: J Neurosci. 2001 Nov 15;21(22):8715-21
references: 11698583
references: J Biol Chem. 2011 Dec 9;286(49):41917-41923
references: 21965686
references: Annu Rev Biochem. 1994;63:823-67
references: 7979255
references: J Neurosci. 1983 Jan;3(1):42-52
references: 6130132
references: Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7363-8
references: 8692999
references: Biophys J. 1981 Mar;33(3):323-51
references: 6261850
references: Neuron. 2006 Sep 21;51(6):755-71
references: 16982421
references: Nat Neurosci. 2012 Jun 10;15(7):988-97
references: 22683683
references: J Neurophysiol. 2001 Jun;85(6):2324-34
references: 11387379
references: J Physiol. 2005 Oct 1;568(Pt 1):199-209
references: 16037093
references: J Biol Chem. 2012 Jan 2;287(1):504-513
references: 22074920
references: Neuron. 1994 Apr;12(4):909-20
references: 7909234
references: Neuron. 2000 Mar;25(3):533-5
references: 10774722
references: Biochem J. 2001 Jan 1;353(Pt 1):1-12
references: 11115393
references: Cell. 1994 Nov 18;79(4):717-27
references: 7954835
references: J Neurosci. 2000 Feb 15;20(4):1374-85
references: 10662828
references: Nature. 1996 Feb 1;379(6564):451-4
references: 8559250
references: Neuron. 1999 Aug;23(4):821-32
references: 10482247
references: Neuron. 1993 Dec;11(6):1007-11
references: 8274272
references: Biochem Biophys Res Commun. 2002 Jan 18;290(2):615-23
references: 11785943
references: J Physiol. 1972 Dec;227(3):691-708
references: 4405553
references: Neuron. 2012 Jul 12;75(1):11-25
references: 22794257
references: Rev Physiol Biochem Pharmacol. 1999;139:33-87
references: 10453692
references: Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16059-64
references: 14673106
references: Trends Pharmacol Sci. 2008 Jul;29(7):333-9
references: 18514334
references: J Neurosci. 2004 Nov 17;24(46):10379-83
references: 15548652
references: Nat Neurosci. 2000 Dec;3(12):1256-65
references: 11100146
references: Neuron. 1994 Dec;13(6):1303-13
references: 7993624
references: Neuron. 1996 Oct;17(4):781-8
references: 8893034
references: Annu Rev Cell Dev Biol. 2000;16:521-55
references: 11031246
references: J Neurosci. 2005 Jul 27;25(30):7071-80
references: 16049184
references: Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1654-9
references: 20080692
references: Nat Neurosci. 2012 Jun 10;15(7):998-1006
references: 22683682
references: J Physiol. 1963 Dec;169:641-62
references: 14082124
references: Cereb Cortex. 2006 Mar;16(3):386-93
references: 15917483
references: J Physiol. 2008 Nov 15;586(22):5503-20
references: 18832426
references: J Neurosci. 1997 Sep 1;17(17):6647-56
references: 9254677
references: Neuron. 2005 May 19;46(4):633-45
references: 15944131
references: Nature. 2004 Oct 14;431(7010):796-803
references: 15483601
references: J Neurosci. 1998 Oct 15;18(20):8214-27
references: 9763467
references: Neuron. 2003 Apr 10;38(1):79-88
references: 12691666
references: J Physiol. 1998 Nov 1;512 ( Pt 3):723-9
references: 9769416
references: J Neurosci. 1997 Nov 1;17(21):8137-46
references: 9334389
references: Annu Rev Physiol. 2002;64:355-405
references: 11826273
references: Nature. 2004 Jun 10;429(6992):671-5
references: 15141227
references: Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12942-6
references: 7809151
references: J Physiol. 1967 Nov;193(2):419-32
references: 6065887
references: Cell. 2011 Oct 28;147(3):666-77
references: 22036572
references: Nat Neurosci. 2002 Mar;5(3):210-7
references: 11865310
references: Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):347-55
references: 10212483
references: Science. 2002 Mar 22;295(5563):2276-9
references: 11910115
references: Trends Pharmacol Sci. 2007 May;28(5):220-8
references: 17403543
references: J Physiol. 1998 Nov 15;513 ( Pt 1):149-55
references: 9782166
references: Trends Neurosci. 1995 Feb;18(2):89-98
references: 7537420
references: Nat Neurosci. 2003 Oct;6(10):1031-8
references: 12947410
references: Sci STKE. 2005 Dec 20;2005(315):re15
references: 16369047
references: Structure. 2005 Dec;13(12):1881-6
references: 16338416
references: Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):542-7
references: 18178620
references: J Neurosci. 2000 Sep 15;20(18):6830-8
references: 10995827
references: J Cell Biol. 1981 Mar;88(3):564-80
references: 6260814
references: Channels (Austin). 2007 Jul-Aug;1(4):225-7
references: 18708749
references: J Biol Chem. 1995 Feb 3;270(5):1971-4
references: 7836421
references: Annu Rev Neurosci. 2004;27:509-47
references: 15217342
references: Nat Struct Mol Biol. 2005 Dec;12(12):1108-15
references: 16299511
references: J Cell Biol. 2007 Jul 30;178(3):489-502
references: 17664337
references: Neuron. 2008 Jan 24;57(2):210-6
references: 18215619
references: Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17069-74
references: 23027954
references: Pharmacol Rev. 2006 Dec;58(4):837-62
references: 17132857
references: J Physiol. 2001 Aug 1;534(Pt 3):861-71
references: 11483715
references: J Neurosci. 2007 Feb 28;27(9):2261-71
references: 17329423
references: J Physiol. 1973 Jan;228(1):241-57
references: 4346703
references: Nature. 1993 Mar 25;362(6418):318-24
references: 8455717
references: J Biol Chem. 2000 Jan 14;275(2):1247-60
references: 10625670
references: Neuron. 2011 Jan 27;69(2):304-16
references: 21262468
references: J Neurophysiol. 2007 Jan;97(1):948-50
references: 17079345
references: Nature. 2001 May 24;411(6836):484-9
references: 11373682
references: Neuron. 2007 Feb 15;53(4):563-75
references: 17296557
references: Nature. 2012 May 13;486(7401):122-5
references: 22678293
references: Trends Neurosci. 1997 Apr;20(4):170-7
references: 9106358
references: Neuron. 2003 Mar 6;37(5):801-11
references: 12628170
references: Nat Neurosci. 2007 Jun;10(6):691-701
references: 17496890
references: Neuron. 1997 Mar;18(3):463-72
references: 9115739
references: Neuron. 1998 Apr;20(4):797-807
references: 9581770
references: Neuron. 2008 Sep 25;59(6):882-901
references: 18817729
references: J Physiol. 1970 May;207(3):789-801
references: 5499746
references: Cell. 2011 Jan 21;144(2):282-95
references: 21241895
references: Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E452-60
references: 22308469
references: J Neurosci. 2005 Jul 27;25(30):7062-70
references: 16049183
references: J Physiol. 1968 Mar;195(2):481-92
references: 4296699