title: Lactose substituted zinc phthalocyanine: a near infrared fluorescence imaging probe for liver cancer targeting.
abstract: A near infrared fluorescence probe, lactose substituted zinc phthalocyanine, [2,9(10),16(17),23(24)-tetrakis((1-(β-d-lactose-2-yl)-1H-1,2,3-triazol-4-yl)methoxyl)phthalocyaninato] zinc(II), was synthesized via click reaction. Structural characterization and optical experiment demonstrated its excellent biocompatibility and fluorescence imaging ability. Near infrared fluorescence imaging in vivo for liver cancer, lung cancer and melanoma cancer with tumor bearing nude mice as models demonstrated that lactose substituted zinc phthalocyanine has specifically targeting ability to liver cancer while no targeting to lung cancer or melanoma, which implied its potential in liver cancer diagnosis as a near infrared optical probe.
authors: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.
authors: Feng
authors: F
authors: Lv
authors: Xujun
authors: X
authors: He
authors: Li
authors: L
authors: Wu
authors: Tianjun
authors: T
authors: Liu
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004355:Drug Stability; D005456:Fluorescent Dyes / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000633:toxicity; D054833:Isoindoles; D007785:Lactose / Q000737:chemistry*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging; D051379:Mice; D008819:Mice, Nude; D009942:Organometallic Compounds / Q000737:chemistry* / Q000633:toxicity; D011859:Radiography; D012995:Solubility; D019265:Spectroscopy, Near-Infrared; D014018:Tissue Distribution; D014183:Transplantation, Heterologous; D017967:Zinc Compounds
chemical_list: D005456:Fluorescent Dyes; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D007785:Lactose