title: A novel structural tree for wrap-proteins, a subclass of (α+β)-proteins.
abstract: In this paper, a novel structural subclass of (α+β)-proteins is presented. A characteristic feature of these proteins and domains is that they consist of strongly twisted and coiled β-sheets wrapped around one or two α-helices, so they are referred to here as wrap-proteins. It is shown that overall folds of the wrap-proteins can be obtained by stepwise addition of α-helices and/or β-strands to the strongly twisted and coiled β-hairpin taken as the starting structure in modeling. As a result of modeling, a structural tree for the wrap-proteins was constructed that includes 201 folds of which 49 occur in known nonhomologous proteins.
authors: a Institute of Protein Research, Russian Academy of Sciences , Pushchino , Moscow Region , 142290 , Russian Federation .
authors: Eugenia A
authors: EA
authors: Boshkova
authors: Alexey B
authors: AB
authors: Gordeev
authors: Alexander V
authors: AV
authors: Efimov
mesh_terms: D030562:Databases, Protein; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D011506:Proteins