title: Beyond the frontiers of neuronal types.
abstract: Cortical neurons and, particularly, inhibitory interneurons display a large diversity of morphological, synaptic, electrophysiological, and molecular properties, as well as diverse embryonic origins. Various authors have proposed alternative classification schemes that rely on the concomitant observation of several multimodal features. However, a broad variability is generally observed even among cells that are grouped into a same class. Furthermore, the attribution of specific neurons to a single defined class is often difficult, because individual properties vary in a highly graded fashion, suggestive of continua of features between types. Going beyond the description of representative traits of distinct classes, we focus here on the analysis of atypical cells. We introduce a novel paradigm for neuronal type classification, assuming explicitly the existence of a structured continuum of diversity. Our approach, grounded on the theory of fuzzy sets, identifies a small optimal number of model archetypes. At the same time, it quantifies the degree of similarity between these archetypes and each considered neuron. This allows highlighting archetypal cells, which bear a clear similarity to a single model archetype, and edge cells, which manifest a convergence of traits from multiple archetypes.
authors: Department of Nonlinear Dynamics, Max Planck Institute for Dynamics and Self-Organization (MPIDS) Göttingen, Germany ; Bernstein Center for Computational Neuroscience Göttingen, Germany.
authors: Demian
authors: D
authors: Battaglia
authors: Anastassios
authors: A
authors: Karagiannis
authors: Thierry
authors: T
authors: Gallopin
authors: Harold W
authors: HW
authors: Gutch
authors: Bruno
authors: B
authors: Cauli
mesh_terms: D000818:Animals; D016208:Databases, Factual; D017143:Fuzzy Logic; D008297:Male; D009474:Neurons / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology*
keywords: atypical cells; barrel cortex; fuzzy sets; interneuron diversity; neuronal diversity; petilla terminology; unsupervised clustering
references: J Physiol. 1948 Mar 15;107(2):165-81
references: 16991796
references: Cereb Cortex. 2009 Jul;19 Suppl 1:i32-41
references: 19386634
references: Nature. 2010 Nov 11;468(7321):232-43
references: 21068832
references: Cereb Cortex. 2013 Feb;23(2):423-41
references: 22357664
references: J Neurosci. 2012 May 9;32(19):6511-6
references: 22573673
references: Front Neural Circuits. 2012 Jun 29;6:36
references: 22754499
references: J Neurophysiol. 2009 Feb;101(2):641-54
references: 19052106
references: Cold Spring Harb Perspect Biol. 2010 May;2(5):a001875
references: 20452960
references: Cereb Cortex. 2009 Apr;19(4):938-50
references: 18787231
references: Front Neural Circuits. 2012 Jul 09;6:44
references: 22787442
references: Nat Neurosci. 2004 Dec;7(12):1345-52
references: 15558066
references: J Neurosci. 2011 Jul 6;31(27):9836-47
references: 21734275
references: Brain Behav Evol. 1975;12(1-2):75-96
references: 1104078
references: J Neurosci. 2009 Jul 22;29(29):9380-9
references: 19625528
references: J Neurophysiol. 1985 Oct;54(4):782-806
references: 2999347
references: Front Neurosci. 2008 Dec 15;2(2):155-67
references: 19225588
references: J Neurophysiol. 1993 Jul;70(1):387-96
references: 8395585
references: Nat Rev Neurosci. 2006 Sep;7(9):687-96
references: 16883309
references: Cereb Cortex. 2004 Dec;14(12):1310-27
references: 15192011
references: Nat Rev Neurosci. 2006 Jul;7(7):563-74
references: 16791145
references: J Neurophysiol. 2008 Oct;100(4):2348-60
references: 18632882
references: Cereb Cortex. 2007 Jan;17(1):81-91
references: 16467567
references: Cereb Cortex. 2011 Aug;21(8):1803-17
references: 21220766
references: Neuron. 2005 Nov 23;48(4):591-604
references: 16301176
references: J Neurophysiol. 2005 Nov;94(5):3009-22
references: 15987765
references: Front Neural Circuits. 2010 May 14;4:12
references: 20617186
references: Proc Natl Acad Sci U S A. 2000 May 23;97(11):6144-9
references: 10823957
references: Front Neural Circuits. 2012 Sep 24;6:65
references: 23015780
references: J Neurosci. 2004 Oct 13;24(41):8940-9
references: 15483113
references: Nat Rev Neurosci. 2004 May;5(5):347-60
references: 15100718
references: Cereb Cortex. 2009 Jul;19(7):1597-615
references: 19015370
references: J Comp Neurol. 1990 Jun 22;296(4):598-613
references: 2358553
references: Front Neuroenergetics. 2010 Jun 23;2:9
references: 20616884
references: Front Neural Circuits. 2012 Aug 10;6:50
references: 22907992
references: Nat Rev Neurosci. 2004 Oct;5(10):793-807
references: 15378039
references: Science. 2000 Jan 14;287(5451):273-8
references: 10634775
references: Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14831-6
references: 17785408
references: Cereb Cortex. 2004 Jun;14(6):690-701
references: 15054049
references: Cereb Cortex. 2006 Oct;16(10):1440-52
references: 16339088
references: Brain Res. 1994 Jun 27;649(1-2):159-73
references: 7525007
references: Nat Neurosci. 2009 Nov;12(11):1424-30
references: 19838180
references: Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3257-62
references: 10077671
references: Trends Neurosci. 1990 Mar;13(3):99-104
references: 1691879
references: Nature. 2009 Oct 29;461(7268):1278-81
references: 19865171
references: Nat Neurosci. 2011 Jan;14(1):100-7
references: 21076426
references: Curr Top Dev Biol. 2009;87:81-118
references: 19427517
references: Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5419-24
references: 21383177
references: J Neurosci. 1996 Apr 15;16(8):2701-15
references: 8786446
references: J Neurosci. 1997 May 15;17(10):3894-906
references: 9133407
references: Science. 2006 Jul 28;313(5786):504-7
references: 16873662
references: J Neurosci. 2009 Mar 18;29(11):3642-59
references: 19295167
references: J Neurosci. 2010 Feb 10;30(6):2165-76
references: 20147544
references: Science. 2003 Mar 21;299(5614):1902-5
references: 12649485
references: Science. 2008 Jul 4;321(5885):53-7
references: 18599766
references: J Neurophysiol. 2005 Nov;94(5):3357-67
references: 16000529
references: J Neurosci. 2006 May 10;26(19):5069-82
references: 16687498
references: J Neurosci. 2010 Dec 15;30(50):16796-808
references: 21159951
references: J Neurophysiol. 2006 Aug;96(2):834-45
references: 16707715
references: Cereb Cortex. 1998 Apr-May;8(3):193-203
references: 9617914
references: J Neurosci. 2000 Jan 15;20(2):763-70
references: 10632605
references: J Physiol. 1997 May 1;500 ( Pt 3):715-38
references: 9161987
references: Cereb Cortex. 2010 Oct;20(10):2333-47
references: 20083553
references: J Neurosci. 2007 Jul 18;27(29):7786-98
references: 17634372
references: Science. 1988 Jun 24;240(4860):1802
references: 17842436
references: J Physiol. 2005 Jan 1;562(Pt 1):9-26
references: 15539390
references: Cereb Cortex. 2010 Dec;20(12):2971-84
references: 20457693
references: Cereb Cortex. 2005 Aug;15(8):1250-60
references: 15616132
references: Neuron. 1998 May;20(5):983-93
references: 9620702
references: J Neurophysiol. 1969 May;32(3):452-84
references: 4977839
references: J Cereb Blood Flow Metab. 2010 Feb;30(2):311-22
references: 19794398
references: Curr Opin Neurobiol. 2011 Feb;21(1):160-8
references: 21074988
references: Front Neural Circuits. 2012 Feb 20;6:4
references: 22363265
references: Front Neurosci. 2010 Dec 08;4:201
references: 21151823
references: Nat Rev Neurosci. 2008 Jul;9(7):557-68
references: 18568015
references: J Neurosci. 2009 May 27;29(21):7040-52
references: 19474331
references: Front Neural Circuits. 2012 Aug 17;6:52
references: 22912602
references: Nature. 2009 Jun 4;459(7247):698-702
references: 19396159