title: Successful treatment of Miescher's cheilitis in Melkersson-Rosenthal syndrome with betamethasone injections and doxycycline.
abstract: We report a case of a 19-year-old girl who presented with 5-year history of swelling of upper lip and fissured tongue treated with dapsone then oral steroids without any improvement. Clinical examination found peripheral facial nerve paralysis and Labial mucosa biopsy showed non-necrotizing giganto-epithelioid granuloma. Diagnosis of Melkersson-Rosenthal syndrome was retaind because of association of cheilitis, lingua plicata and facial paralysis. Given the failure of dapsone and oral steroid we suggested an association of betamethasone injection and doxycycline. Gradual and permanent reduction of the upper lip volume was observed. One year follow up objectified no reactivation of cheilitis.
authors: Department of Dermatology Venerology Ibn Rusd UHC, Casablanca, Morocco.
authors: Lamia
authors: L
authors: Oudrhiri
authors: Soumiya
authors: S
authors: Chiheb
authors: Farida
authors: F
authors: Marnissi
authors: Soumaya
authors: S
authors: Zamiati
authors: Hakima
authors: H
authors: Benchikhi
mesh_terms: D001623:Betamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D003622:Dapsone / Q000627:therapeutic use; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D015552:Injections, Intralesional; D008556:Melkersson-Rosenthal Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D003622:Dapsone; D001623:Betamethasone; D004318:Doxycycline
keywords: Melkersson-Rosenthal syndrome; Miescher's cheilitis granulomatosa; treatment
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