title: Localized Ewing sarcoma of the tibia.
abstract: Ewing sarcoma (ES) is a high-grade malignant primary round cell tumour of bone in which there is commonly extension into extraosseous soft tissues at the time of diagnosis. This report details the clinical, radiological and pathological features of a case of ES of the tibia in which there was extensive osseous involvement but no infiltration beyond the periosteum into surrounding soft tissue. We also record the findings of one other ES case that exhibited similar behaviour. Both cases were male, involved the tibia and had the characteristic t (11;22) (q24;q12) translocation. No recurrence of tumour or metastasis has been seen in these two cases, both of which have had 6 years follow-up. Our findings indicate that there is heterogeneity in the behaviour of ES and show that localized ES is associated with a good prognosis.
authors: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford OX7HE, UK. nick.athanasou@ndorms.ox.ac.uk.
authors: Takeshi G
authors: TG
authors: Kashima
authors: Nimali G
authors: NG
authors: Gamage
authors: Uta
authors: U
authors: Dirksen
authors: Christopher Lmh
authors: CL
authors: Gibbons
authors: Simon J
authors: SJ
authors: Ostlere
authors: Nicholas A
authors: NA
authors: Athanasou
references: J Clin Oncol. 2010 Apr 20;28(12):1982-8
references: 20308673
references: J Pediatr Orthop B. 2013 May;22(3):222-7
references: 22094991
references: Med Pediatr Oncol. 1999 Mar;32(3):186-95
references: 10064186
references: Int J Radiat Oncol Biol Phys. 1993 Feb 15;25(3):431-8
references: 8436521
references: J Orthop Surg (Hong Kong). 2005 Apr;13(1):88-92
references: 15872409
references: Semin Diagn Pathol. 1996 Aug;13(3):242-9
references: 8875712
references: Hum Pathol. 2008 Jan;39(1):49-55
references: 17904616
references: Int J Radiat Oncol Biol Phys. 1991 Mar;20(3):389-95
references: 1995522
references: Cancer. 1989 Apr 15;63(8):1477-86
references: 2924256
references: J Clin Oncol. 1989 Feb;7(2):208-13
references: 2915236
references: Acta Orthop Belg. 2009 Dec;75(6):836-41
references: 20166369
references: Cancer. 1983 Mar 1;51(5):913-7
references: 6821856
references: Clin Sarcoma Res. 2012 Feb 08;2(1):7
references: 22587879
references: Skeletal Radiol. 2005 May;34(5):285-9
references: 15838704