title: ManR, a transcriptional regulator of the β-mannan utilization system, controls the cellulose utilization system in Aspergillus oryzae.
abstract: ManR, a DNA-binding protein possessing the Zn(II)(2)Cys(6) binuclear cluster domain, acts as a positive regulator of mannanolytic enzyme genes in Aspergillus oryzae. In this study, we found that ManR controlled the expression not only of mannanolytic enzyme genes but also of cellulolytic enzyme genes in A. oryzae, based on DNA microarray analysis of a manR-disruptant and a manR-overexpressing strain. A new model for the regulation of cellulase and hemicellulase genes mediated by ManR and XlnR in A. oryzae is proposed.
authors: Noda Institute for Scientific Research, Noda, Chiba, Japan. maogawa@mail.kikkoman.co.jp
authors: Masahiro
authors: M
authors: Ogawa
authors: Tetsuo
authors: T
authors: Kobayashi
authors: Yasuji
authors: Y
authors: Koyama
mesh_terms: D001236:Aspergillus oryzae / Q000235:genetics* / Q000378:metabolism; D002480:Cellulase / Q000235:genetics / Q000378:metabolism; D002482:Cellulose / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D006026:Glycoside Hydrolases / Q000235:genetics / Q000378:metabolism; D008351:Mannans / Q000378:metabolism*; D046228:Microarray Analysis; D011401:Promoter Regions, Genetic; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D005656:Fungal Proteins; D008351:Mannans; D015534:Trans-Activators; D002482:Cellulose; D006026:Glycoside Hydrolases; C023305:hemicellulase; D002480:Cellulase