title: Comparison of combined application treatment with one-visit  varnish treatments in an orthodontic population.
abstract: OBJECTIVE
  To evaluate the effect of chlorhexidine-thymol varnish alone, its combination with chlorhexidine-fluoride containing dentifrice and fluoride varnish on oral hygiene and caries prevention in orthodontic patients.
  
  
  METHODS
  Sixty patients, aged 12-18, with orthodontic fixed appliances were randomly assigned into three groups as follows: Group 1 (n=20): 1% chlorhexidine and 1% thymol varnish (CervitecPlus); Group 2 (n=20): CervitecPlus+ 0.2% chlorhexidine and 0.2% sodium fluoride (900 ppm fluoride) (CervitecGel)); and Group 3 (n=20): 0.1% fluoride varnish (Fluor Protector). Mutans streptococci (MS), lactobacilli (LB) levels, buffering capacity (BC), visible plaque index (VPI), and gingival bleeding index (GBI) scores were evaluated at four stages: T0, before orthodontic bonding; T₁, one week after orthodontic bonding; T₂, one week; and T₃, four weeks after the first application, respectively. Inter and intra group comparisons were made by the Kruskal-Wallis, Mann-Whitney U, Friedman and Wilcoxon Signed-Rank tests with Bonferroni step-down correction (P<0.017).
  
  
  RESULTS
  Significantly lower MS and LB levels were found in Group 2 than Group 1 (T₂) and 3 (T₂, T₃) (P<0.017). Groups 1-2 (T₂) showed significantly higher BC (P<0.017) and lower VPI and GBI (P<0.017) scores compared with Group 3. Decreased MS levels at T₂ (P<0.017) and T₃ (P>0.017) were found in Group1-2 compared with T0. Significantly lower LB levels were recorded in Group 2 at T₂ compared with T₀ (P<0.017) while no significant differences were seen in Group 1 and 3 (P>0.017).
  
  
  CONCLUSIONS
  Addition of CervitecPlus+CervitecGel combination to the standard oral hygiene regimen may be beneficial for orthodontic patients for maintaining oral health by reducing bacterial colonisation and gingivitis.
authors: Karadeniz Technical University Faculty of Dentistry, Department of Pediatric Dentistry, Trabzon-Turkey. dtozgul@gmail.com
authors: Ozgul
authors: O
authors: Baygin
authors: Tamer
authors: T
authors: Tuzuner
authors: Mehmet-Birol
authors: MB
authors: Ozel
authors: Ozge
authors: O
authors: Bostanoglu
mesh_terms: D000293:Adolescent; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002648:Child; D002710:Chlorhexidine / Q000627:therapeutic use*; D003731:Dental Caries / Q000517:prevention & control*; D004338:Drug Combinations; D005459:Fluorides / Q000627:therapeutic use*; D005460:Fluorides, Topical / Q000627:therapeutic use*; D006801:Humans; D009819:Office Visits; D009971:Orthodontics, Corrective; D011446:Prospective Studies; D016037:Single-Blind Method; D013943:Thymol / Q000627:therapeutic use*; D014100:Toothpastes
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D005460:Fluorides, Topical; D014100:Toothpastes; C079161:chlorhexidine, thymol drug combination; D013943:Thymol; D005459:Fluorides; D002710:Chlorhexidine
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