title: A unified model for ferritin iron loading by the catalytic center: implications for controlling "free iron" during oxidative stress.
abstract: IRONING OUT THE DIFFERENCES: A unified model shows that the catalytic centers of human H ferritin and archaeal P. furiosus ferritin load iron according to the same mechanism. This model could help our understanding of the processes of controlling the various subcellular concentrations of iron during inflammation.
authors: Chemistry & Biochemistry, Brigham Young University, C210 BNSN Building, Provo, UT 84602, USA. rwatt@chem.byu.edu
authors: Richard K
authors: RK
authors: Watt
mesh_terms: D019843:Archaeal Proteins / Q000737:chemistry / Q000378:metabolism*; D020134:Catalytic Domain; D005293:Ferritins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D008954:Models, Biological; D018384:Oxidative Stress; D020027:Pyrococcus furiosus / Q000737:chemistry / Q000378:metabolism*
chemical_list: D019843:Archaeal Proteins; D005293:Ferritins; D007501:Iron