title: Comparison of the effect of combination therapy with an angiotensin II receptor blocker and either a low-dose diuretic or calcium channel blocker on cardiac hypertrophy in patients with hypertension.
abstract: Left ventricular hypertrophy (LVH) regression is an important issue in hypertensive patients. Patients with LVH who had received the angiotensin receptor blocker (ARB) treatment for 8 weeks and had not reached the target blood pressure level were enrolled in the study. Patients were assigned to either losartan (50 mg)/hydrochlorothiazide (HCTZ, 12.5 mg) group or ARB + CCB group (usual dose of ARB and calcium channel blocker, CCB). After 48 weeks, LV mass index was found to be reduced significantly in the losartan/HCTZ group but not in the ARB + CCB group. These results suggest that combination therapy of an ARB and diuretic has greater potential to cause regression compared with an ARB and CCB.
authors: Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine , Toon City, Ehime , Japan.
authors: Takafumi
authors: T
authors: Okura
authors: Ken-ichi
authors: K
authors: Miyoshi
authors: Jun
authors: J
authors: Irita
authors: Daijiro
authors: D
authors: Enomoto
authors: Masanori
authors: M
authors: Jotoku
authors: Tomoaki
authors: T
authors: Nagao
authors: Kouki
authors: K
authors: Watanabe
authors: Hiroshi
authors: H
authors: Matsuoka
authors: Toshiaki
authors: T
authors: Ashihara
authors: Jitsuo
authors: J
authors: Higaki
mesh_terms: D000368:Aged; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use*; D001794:Blood Pressure; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000379:methods; D004452:Echocardiography; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000627:therapeutic use*; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D057911:Angiotensin Receptor Antagonists; D002121:Calcium Channel Blockers; D004232:Diuretics; D006852:Hydrochlorothiazide; D019808:Losartan