title: Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives.
abstract: Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4-chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In addition, thioamide derivatives (6a-g) have higher growth inhibition than their carboxamide analogs.
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University , Kayisdagi, Istanbul , Turkey , and.
authors: Enise Ece
authors: EE
authors: Gurdal
authors: Irem
authors: I
authors: Durmaz
authors: Rengul
authors: R
authors: Cetin-Atalay
authors: Mine
authors: M
authors: Yarim
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001559:Benzhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013854:Thioamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001559:Benzhydryl Compounds; D010879:Piperazines; D013854:Thioamides