title: Copy number variations in IL22 gene are associated with Psoriasis vulgaris.
abstract: Psoriasis vulgaris (PsV) is a frequent, chronically relapsing, immune-mediated systemic disease with characteristic skin changes. IL22 is a cytokine of IL10 family, with significant proliferative effect on different cell lines. Copy number variations (CNV) have been discovered to have phenotypic consequences and are associated with various types of diseases. In the work presented here we analyzed the copy number variations in IL22 gene of exon1 and exon5. Our results showed that the IL22 gene exon1 was significantly associated with psoriasis severity (P<0.0001). However, the association between IL22 gene exon5 copy numbers and psoriasis was not detected.
authors: Department of Physiology, University of Tartu, Tartu, Estonia. ele.prans@ut.ee
authors: Ele
authors: E
authors: Prans
authors: Külli
authors: K
authors: Kingo
authors: Tanel
authors: T
authors: Traks
authors: Helgi
authors: H
authors: Silm
authors: Eero
authors: E
authors: Vasar
authors: Sulev
authors: S
authors: Kõks
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D056915:DNA Copy Number Variations; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D000097043:Interleukin-22