title: Characterization of ovine Nectin-4, a novel peste des petits ruminants virus receptor.
abstract: Small ruminants infected with peste des petits ruminants virus exhibit lesions typical of epithelial infection and necrosis. However, the only established host receptor for this virus is the immune cell marker signaling lymphocyte activation molecule (SLAM). We have confirmed that the ovine Nectin-4 protein, when overexpressed in epithelial cells, permits efficient replication of PPRV. Furthermore, this gene was predominantly expressed in epithelial tissues and encoded by multiple haplotypes in sheep breeds from around the world.
authors: The Pirbright Institute, Surrey, United Kingdom.
authors: Jamie
authors: J
authors: Birch
authors: Nicholas
authors: N
authors: Juleff
authors: Michael P
authors: MP
authors: Heaton
authors: Ted
authors: T
authors: Kalbfleisch
authors: James
authors: J
authors: Kijas
authors: Dalan
authors: D
authors: Bailey
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D004847:Epithelial Cells / Q000821:virology; D000075983:Nectins; D018107:Peste-des-petits-ruminants virus / Q000254:growth & development / Q000502:physiology*; D011991:Receptors, Virus / Q000378:metabolism*; D012756:Sheep; D053585:Virus Attachment
chemical_list: D015815:Cell Adhesion Molecules; D000075983:Nectins; D011991:Receptors, Virus
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