title: Catalytic enantioselective alkylation of aldehydes by using organozinc halide reagents.
abstract: Functionalized alkylzinc halides can be employed in the enantioselective addition to aldehydes by using a titanium(IV) catalyst derived from a H(8)-binaphthol derivative in the presence of [Ti(OiPr)(4)] and MgBr(2). A range of functionalities, including olefin, chlorine atoms, protected alcohols, amides, and cyano groups, are tolerated in the present reaction, providing the corresponding functionalized alcohols in high yields and enantioselectivities (see scheme).
authors: Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
authors: Yuichiro
authors: Y
authors: Kinoshita
authors: Shinichi
authors: S
authors: Kanehira
authors: Yasuki
authors: Y
authors: Hayashi
authors: Toshiro
authors: T
authors: Harada