title: Genetic variation and cognitive dysfunction one year after cardiac surgery.
abstract: Various studies have implicated a potential association between candidate gene polymorphisms and postoperative cognitive dysfunction, yet corroborative studies are lacking. We investigated the variants in genes encoding platelet glycoprotein-IIIa and apolipoprotein-E and their relationship with postoperative cognitive dysfunction one year after cardiac surgery. A total of 155 patients were studied; neuropsychological testing demonstrated cognitive dysfunction in 31 (20%) patients at one-year follow-up. No differences were detected with respect to baseline characteristics, pre-operative variables and surgical data between the patients with and without cognitive dysfunction. The Pl(A2) -allele of the platelet glycoprotein-IIIa gene was present in 13 (42%) and 25 (20%) patients with and without cognitive dysfunction, respectively, p = 0.012. The apolipoprotein E-ε4 allele was present in 9 (29%) and 24 (19%) patients with and without cognitive dysfunction, respectively, p = 0.24. Both the Pl(A2) and apolipoprotein-ε4 alleles were present together in 6 (19%) and 5 (4%) patients with and without cognitive dysfunction, respectively, p = 0.003. Validation of these findings is required in age-adjusted non-surgical controls.
authors: University of Toronto, Toronto, Canada.
authors: A
authors: A
authors: Stewart
authors: R
authors: R
authors: Katznelson
authors: N
authors: N
authors: Kraeva
authors: J
authors: J
authors: Carroll
authors: T
authors: T
authors: Pickworth
authors: V
authors: V
authors: Rao
authors: G
authors: G
authors: Djaiani
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D039661:Integrin beta3