title: [Stable life predection of Hangbaiju and Gongju by classic constant temperature accelerated test method].
abstract: OBJECTIVE
  To study the stability of chlorogenic acid, cynaroside and 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju and to predict their term of validity.
  
  
  METHODS
  Hangbaiju and Gongju were incubated in an environmental chamber at different temperatures and relative humidities. After the incubation, quantitative determination of chlorogenic acid, cynaroside, 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju were measured by HPLC. The effective period of the preparation was calculated according to Arrhinius index law. Quantitative determination of 3,5-O-discaffeoylquinc acid, cynaroside, chlorogenic acid in Hangju and Gongju were analyzed by HPLC.
  
  
  RESULTS
  The stable life of Hangbaiju has been determined as 2.25 years. The stable life of Gongju has been determined as 4.31 years.
  
  
  CONCLUSIONS
  The high temperature is not conducive to the stability of Hangbaiju and Gongju, which needs to be placed in a dark and cool place.
authors: Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China.
authors: Da-Peng
authors: DP
authors: Zhang
authors: Zhi-Ping
authors: ZP
authors: Xue
authors: Jie
authors: J
authors: Liu
authors: Wen-Yi
authors: WY
authors: Kang
mesh_terms: D002726:Chlorogenic Acid / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D031202:Chrysanthemum / Q000737:chemistry*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D013696:Temperature
chemical_list: D004365:Drugs, Chinese Herbal; D002726:Chlorogenic Acid