title: Does adjuvant long-acting gestagen therapy improve the outcome of hysteroscopic endometrial resection in women of low-resource settings with heavy menstrual bleeding?
abstract: OBJECTIVE
  To test for the hypothesis of the beneficial effect of long-acting gestagens as an adjuvant postoperative therapy on the outcome of hysteroscopic transcervical endometrial resection (TCRE) in women of low-resource settings and suffering from ovulatory heavy menstrual bleeding (menorrhagia).
  
  
  METHODS
  Randomized controlled trial (Canadian Task Force classification I).
  
  
  METHODS
  Low-resource tertiary care university hospital.
  
  
  METHODS
  Seventy-one premenopausal women with established ovulatory menorrhagia.
  
  
  METHODS
  After randomization, 37 patients were treated with TCRE plus gestagen and 34 patients with TCRE alone.
  
  
  RESULTS
  Variations in menstrual patterns and bleeding scores, as well as amenorrhea and repeat surgery rates with treatment, were determined 1 year after resection. In those who continued to menstruate at 6 months, treatment with TCRE plus gestagen was associated with a significant reduction in the number of days bleeding from 7.2 to 3.4 (p ≤ .0001), increased cycle length from 24 to 30 (p = .02), a 60% reduction in dysmenorrhea score from 62 to 25 (p ≤ .0001), and a 60% reduction in premenstrual syndrome score from 55 to 22 (p = .04). Amenorrhea rates at 12 months in the TCRE plus gestagen and TCRE alone groups were 40% versus 26% (p = .02), with combined amenorrhea and hypomenorrhea rates of 75% versus 64% (p = .02), respectively. At 12 months, repeat surgery rates were higher in the TCRE alone group (21% vs 3%, p < .05).
  
  
  CONCLUSIONS
  In a low-resource setting, the adjuvant postoperative long-acting gestagen therapy has proven to be superior in inducing amenorrhea after hysteroscopic TCRE.
authors: Department of OB/GYN, Mansoura University Hospital, Mansoura Faculty of Medicine, Mansoura, Egypt. tarekshokeir1@hotmail.com
authors: Tarek
authors: T
authors: Shokeir
authors: Mouhamed
authors: M
authors: Eid
authors: El-Said
authors: el-S
authors: Abdel-Hady
mesh_terms: D000328:Adult; D017024:Chemotherapy, Adjuvant; D003906:Developing Countries; D004412:Dysmenorrhea / Q000150:complications / Q000628:therapy; D004717:Endometrium / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015907:Hysteroscopy; D008595:Menorrhagia / Q000150:complications / Q000628:therapy*; D008875:Middle Aged; D017060:Patient Satisfaction; D011372:Progestins / Q000008:administration & dosage / Q000627:therapeutic use*; D012086:Reoperation; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D011372:Progestins