title: Cellular organization of the transfer of genetic information.
abstract: Each step involved in the transfer of genetic information is spatially regulated in eukaryotic cells, as transcription, translation and mRNA degradation mostly occur in distinct functional compartments (e.g., nucleus, cytoplasm and P-bodies). At first glance in bacteria, these processes seem to take place in the same compartment - the cytoplasm - because of the conspicuous absence of membrane-enclosed organelles. However, it is becoming increasingly evident that mRNA-related processes are also spatially organized inside bacterial cells, and that this organization affects cellular function. The aims of this review are to summarize the current knowledge about this organization and to consider the mechanisms and forces shaping the cell interior. The field stands at an exciting point where new technologies are making long-standing questions amenable to experimentation.
authors: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
authors: Manuel
authors: M
authors: Campos
authors: Christine
authors: C
authors: Jacobs-Wagner
mesh_terms: D001419:Bacteria / Q000235:genetics* / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D003593:Cytoplasm / Q000378:metabolism; D015388:Organelles / Q000378:metabolism; D014176:Protein Biosynthesis; D020871:RNA Stability; D014158:Transcription, Genetic
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