title: Paracetamol and ketorolac pharmacokinetics and metabolism at delivery and during postpartum.
abstract: During pregnancy, changes in renal elimination, body composition and metabolic activity occur. Since these important alterations in physiology also affect drug disposition, pregnancy warrants a focused approach. Despite these differences, even commonly administered drugs have not undergone pharmacokinetic evaluation in pregnant women or at delivery. This is also true for analgesics routinely administered by anesthesiologists during pregnancy or at delivery, like intravenous (i.v.) paracetamol or ketorolac. We report on our observations on i.v. paracetamol and ketorolac disposition following cesarean delivery to illustrate the feasibility of such focused studies and the impact of pregnancy on drug disposition. The clinical relevance of these observations are subsequently discussed, and some future research directions are suggested.
authors: Department of Development and Regeneration, KU Leuven and University Hospitals Leuven, Leuven, Belgium. karel.allegaert@uzleuven.be
authors: K
authors: K
authors: Allegaert
authors: K
authors: K
authors: van Calsteren
authors: S
authors: S
authors: Hendrickx
authors: J
authors: J
authors: Kelchtermans
authors: A
authors: A
authors: Smits
authors: A
authors: A
authors: Kulo
authors: M
authors: M
authors: van de Velde
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001711:Biotransformation; D001835:Body Weight / Q000502:physiology; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D020911:Ketorolac Tromethamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D049590:Postpartum Period / Q000502:physiology*; D011247:Pregnancy
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D020911:Ketorolac Tromethamine