title: Modelling tumour oxygenation, reoxygenation and implications on treatment outcome.
abstract: Oxygenation is an important component of the tumour microenvironment, having a significant impact on the progression and management of cancer. Theoretical determination of tissue oxygenation through simulations of the oxygen transport process is a powerful tool to characterise the spatial distribution of oxygen on the microscopic scale and its dynamics and to study its impact on the response to radiation. Accurate modelling of tumour oxygenation must take into account important aspects that are specific to tumours, making the quantitative characterisation of oxygenation rather difficult. This paper aims to discuss the important aspects of modelling tumour oxygenation, reoxygenation, and implications for treatment.
authors: Medical Radiation Physics, Stockholm University and Karolinska Institutet, 171 76 Stockholm, Sweden. iuliana.livia.dasu@ki.se
authors: Iuliana
authors: I
authors: Toma-Dasu
authors: Alexandru
authors: A
authors: Dasu
mesh_terms: D000465:Algorithms; D001692:Biological Transport; D015687:Cell Hypoxia; D003198:Computer Simulation; D018450:Disease Progression; D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D016896:Treatment Outcome
chemical_list: D010100:Oxygen
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