title: Prediction of psychosis in clinical high-risk patients by the Schizotypal Personality Questionnaire. Results of the EPOS project.
abstract: OBJECTIVE
  Schizotypal features indicate proneness to psychosis in the general population. It is also possible that they increase transition to psychosis (TTP) among clinical high-risk patients (CHR). Our aim was to investigate whether schizotypal features predict TTP in CHR patients.
  
  
  METHODS
  In the EPOS (European Prediction of Psychosis Study) project, 245 young help-seeking CHR patients were prospectively followed for 18 months and their TTP was identified. At baseline, subjects were assessed with the Schizotypal Personality Questionnaire (SPQ). Associations between SPQ items and its subscales with the TTP were analysed in Cox regression analysis.
  
  
  RESULTS
  The SPQ subscales and items describing ideas of reference and lack of close interpersonal relationships were found to correlate significantly with TTP. The co-occurrence of these features doubled the risk of TTP.
  
  
  CONCLUSIONS
  Presence of ideas of reference and lack of close interpersonal relations increase the risk of full-blown psychosis among CHR patients. This co-occurrence makes the risk of psychosis very high.
authors: Department of Psychiatry, University of Turku, Turku, Finland; Psychiatric Clinic, Turku University Central Hospital, Turku, Finland; Turku Psychiatric Clinic, Turku Mental Health Centre, Turku, Finland. Electronic address: Raimo.K.R.Salokangas@tyks.fi.
authors: R K R
authors: RK
authors: Salokangas
authors: P
authors: P
authors: Dingemans
authors: M
authors: M
authors: Heinimaa
authors: T
authors: T
authors: Svirskis
authors: S
authors: S
authors: Luutonen
authors: J
authors: J
authors: Hietala
authors: S
authors: S
authors: Ruhrmann
authors: G
authors: G
authors: Juckel
authors: H
authors: H
authors: Graf von Reventlow
authors: D
authors: D
authors: Linszen
authors: M
authors: M
authors: Birchwood
authors: P
authors: P
authors: Patterson
authors: F
authors: F
authors: Schultze-Lutter
authors: J
authors: J
authors: Klosterkötter
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010551:Personality; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D011618:Psychotic Disorders / Q000175:diagnosis*; D012569:Schizotypal Personality Disorder / Q000175:diagnosis*; D011795:Surveys and Questionnaires
keywords: Clinical high-risk patients; Schizotypal features; Transition to psychosis