title: [Silica-coated ethosome as a novel oral delivery system for enhanced oral bioavailability of curcumin].
abstract: The aim of this study is to investigate the feasibility of silica-coated ethosome as a novel oral delivery system for the poorly water-soluble curcumin (as a model drug). The silica-coated ethosomes loading curcumin (CU-SE) were prepared by alcohol injection method with homogenization, followed by the precipitation of silica by sol-gel process. The physical and chemical features of CU-SEs, and curcumin release were determined in vitro. The pharmacodynamics and bioavailability measurements were sequentially performed. The mean diameter of CU-SE was (478.5 +/- 80.3) nm and the polydispersity index was 0.285 +/- 0.042, while the mean value of apparent drug entrapment efficiency was 80.77%. In vitro assays demonstrated that CU-SEs were significantly stable with improved release properties when compared with curcumin-loaded ethosomes (CU-ETs) without silica-coatings. The bioavailability of CU-SEs and CU-ETs was 11.86- and 5.25-fold higher, respectively, than that of curcumin suspensions (CU-SUs) in in vivo assays. The silica coatings significantly promoted the stability of ethosomes and CU-SEs exhibited 2.26-fold increase in bioavailablity relative to CU-ETs, indicating that the silica-coated ethosomes might be a potential approach for oral delivery of poorly water-soluble drugs especially the active ingredients of traditional Chinese medicine with improved bioavailability.
authors: College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China. chongli2009@gmail.com
authors: Chong
authors: C
authors: Li
authors: Li
authors: L
authors: Deng
authors: Yan
authors: Y
authors: Zhang
authors: Ting-Ting
authors: TT
authors: Su
authors: Yin
authors: Y
authors: Jiang
authors: Zhang-Bao
authors: ZB
authors: Chen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D004337:Drug Carriers; D000431:Ethanol / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008297:Male; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility
chemical_list: D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D008081:Liposomes; D000431:Ethanol; D012822:Silicon Dioxide; D003474:Curcumin