title: Apoptosis-related Fas and FasL gene polymorphisms' associations with knee osteoarthritis.
abstract: To investigate the associations between Fas and FasL gene polymorphisms and susceptibility to knee osteoarthritis. Genomic DNA was obtained from 146 patients with knee osteoarthritis and 102 healthy controls. Genotype distributions and allelic frequencies of four polymorphisms of Fas (-670 G>A rs1800682, -1377 G>A rs2234767) and FasL (IVS2nt-124 A>G rs5030772, -844 T>C rs763110) genes were compared between the groups. Thereafter, this association was investigated between patients and controls of the same sex. There were significant differences between patients with knee osteoarthritis and controls regarding the genotype distributions and allelic frequencies of Fas-1377 G>A polymorphism (P = 0.0001 and P = 0.005, respectively). The Fas-1377 GG genotype and G allele were significantly more frequent in patients with knee osteoarthritis than in controls. Genotype distributions and allelic frequencies of Fas-670 G>A, FasL-844 T>C, and FasL IVS2nt-124 A>G polymorphisms did not differ between the groups (P > 0.05). However, there were no significant differences between patients and controls of the same sex (P > 0.05). These findings suggest that the Fas-1377 G>A polymorphism in the Fas gene related with apoptosis may contribute to susceptibility to knee osteoarthritis in the Turkish population. There is a need for further studies to evaluate the role of apoptosis in large cohorts.
authors: Department of Physical Medicine and Rehabilitation Medical Faculty, Mersin University, Liparis Plaza-1 sitesi, H-Blok, 7/15, Mezitli, Mersin, Turkey. mksezgin@gmail.com
authors: Melek
authors: M
authors: Sezgin
authors: İbrahim Ömer
authors: İÖ
authors: Barlas
authors: Seyfi
authors: S
authors: Yıldır
authors: Gözde
authors: G
authors: Türköz
authors: Handan Çamdeviren
authors: HÇ
authors: Ankaralı
authors: Günşah
authors: G
authors: Şahin
authors: Mehmet Emin
authors: ME
authors: Erdal
mesh_terms: D000368:Aged; D000483:Alleles; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014421:Turkey; D019014:fas Receptor / Q000235:genetics*
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D019014:fas Receptor
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