title: DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation.
abstract: Emphasis has been placed in this article dedicated to DNA damage on recent aspects of the formation and measurement of oxidatively generated damage in cellular DNA in order to provide a comprehensive and updated survey. This includes single pyrimidine and purine base lesions, intrastrand cross-links, purine 5',8-cyclonucleosides, DNA-protein adducts and interstrand cross-links formed by the reactions of either the nucleobases or the 2-deoxyribose moiety with the hydroxyl radical, one-electron oxidants, singlet oxygen, and hypochlorous acid. In addition, recent information concerning the mechanisms of formation, individual measurement, and repair-rate assessment of bipyrimidine photoproducts in isolated cells and human skin upon exposure to UVB radiation, UVA photons, or solar simulated light is critically reviewed.
authors: Direction des Sciences de la Matière, Institut Nanosciences et Cryogénie, CEA/Grenoble, 38054 Grenoble, France. jean.cadet@cea.fr
authors: Jean
authors: J
authors: Cadet
authors: J Richard
authors: JR
authors: Wagner
mesh_terms: D002851:Chromatography, High Pressure Liquid; D018736:DNA Adducts / Q000737:chemistry; D004249:DNA Damage; D013058:Mass Spectrometry; D009711:Nucleotides / Q000737:chemistry; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D018736:DNA Adducts; D009711:Nucleotides; D017382:Reactive Oxygen Species
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