title: Dyspnoea and the ovaries: a rare presentation of Krukenberg tumour.
abstract: Krukenberg tumour is a metastatic signet-ring adenocarcinoma of the ovary, usually with a gastrointestinal primary detected metachronously or synchronously. We present here a case of a 48 year-old woman who presented with a prolonged history of dyspnoea on exertion. Workup had revealed a pelvic mass. Thoracocentesis of her pleural effusion, with cytology, and pathology reports from her total abdominal hysterectomy with bilateral salpingo-oophorectomy revealed a carcinoma with signet-ring cells. Immunostains were positive for CDX2, CK7 and CK20, which was highly suggestive of a gastric primary. Colonoscopy was negative, and an oesophagogastroduodenoscopy revealed a few small crater ulcers, the biopsy of which was negative for cancer. A right-sided pleurodesis was performed for the unremitting malignant effusion, and a PleurX catheter was placed in her left pleural space. She was discharged home with a very poor prognosis.
authors: Department of Medicine, University of Louisville, Kentucky, USA.
authors: Wasiq Faraz
authors: WF
authors: Rawasia
authors: Udit
authors: U
authors: Chaddha
authors: Karim
authors: K
authors: El-Kersh
authors: Rafael L
authors: RL
authors: Perez
mesh_terms: D004417:Dyspnea / Q000209:etiology*; D005260:Female; D006801:Humans; D007725:Krukenberg Tumor / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D010053:Ovary / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
references: An Med Interna. 1996 Nov;13(11):564-5
references: 9019222
references: Prim Care Update Ob Gyns. 1998 Jul 1;5(4):157-158
references: 10838292
references: Jpn J Clin Oncol. 2005 Apr;35(4):221-3
references: 15845573
references: Cancer. 1986 Feb 15;57(4):751-60
references: 3002584
references: N Y State J Med. 1972 Mar 15;72(6):727-30
references: 4501545
references: Gynecol Obstet Invest. 1999;48(1):61-5
references: 10394095
references: Eur J Surg Oncol. 2009 Jan;35(1):92-7
references: 18632244
references: Int J Gynecol Pathol. 2004 Jan;23(1):45-51
references: 14668550
references: Gan To Kagaku Ryoho. 2010 Nov;37(12):2591-3
references: 21224649
references: Gynecol Oncol. 2001 Jul;82(1):105-9
references: 11426970
references: Rev Med Univ Navarra. 2007 Jul-Sep;51(3):19-22
references: 18183782
references: Gynecol Oncol. 2005 Aug;98(2):235-41
references: 15982725
references: Am J Surg Pathol. 2006 Mar;30(3):277-99
references: 16538048
references: Nihon Shokakibyo Gakkai Zasshi. 2009 Apr;106(4):529-35
references: 19346721
references: Gynecol Oncol. 2004 Apr;93(1):248-51
references: 15047245
references: Obstet Gynecol. 1960 Mar;15:351-60
references: 13845875
references: Dig Surg. 2000;17(4):418-9
references: 11053957
references: Hum Pathol. 2002 Nov;33(11):1078-85
references: 12454811
references: Br J Cancer. 1995 Jan;71(1):92-6
references: 7819057
references: J Chir (Paris). 1996;133(9-10):427-31
references: 9296016
references: Arch Pathol Lab Med. 2006 Nov;130(11):1725-30
references: 17076540
references: J Comput Assist Tomogr. 1996 May-Jun;20(3):393-8
references: 8626898
references: Gynecol Obstet Invest. 2002;54(4):221-7
references: 12592066
references: Ann Pathol. 2000 May;20(3):202-6
references: 10891713
references: Surg Today. 2003;33(5):387-91
references: 12734738