title: Effects of Canavalia lectins on acute inflammation in sensitized and non-sensitized rats.
abstract: The anti-inflammatory activity of Canavalia seed lectins (Canavalia gladiata [CGL], Canavalia maritima [ConM] and Canavalia brasiliensis [ConBr]) was evaluated by intravenous administration in rats. In non-sensitized rats, cellular edema elicited by carrageenan was reduced (45-51 %) by ConM and (44-59 %) by CGL. Osmotic edema elicited by dextran was reduced by ConM and CGL in 27 % and 29 %. ConM and CGL reduced the edema elicited by L-arginine in 53 % and that of prostaglandin E2 in 48 % and 36 %. Leukocyte migration elicited by carrageenan was reduced in 49 % by ConM and in 55 % by CGL (attenuated in 4× by glucose) and peritoneal TNF-α content in 82 %. In rats sensitized, ConM inhibited the paw edema and leukocyte migration elicited by ovalbumin in 34 % and 70 %. ConM and CGL are anti-inflammatory, mainly in cellular events mediated by prostaglandin E₂, nitric oxide and TNF-α in non-sensitized rats. However, only ConM is anti-inflammatory in sensitized rats. CGL effect involves the lectin domain.
authors: Institute of Biomedical Sciences, State University of Ceará, Av. Paranjana, 1700, 60740-000 Fortaleza, CE, Brazil.
authors: Nilson Vieira
authors: NV
authors: Pinto
authors: Benildo Sousa
authors: BS
authors: Cavada
authors: Lucas Ferreira
authors: LF
authors: Brito
authors: Ronniery Ilario
authors: RI
authors: Pereira
authors: Mayara Torquato Lima
authors: MT
authors: da Silva
authors: Rondinelle Ribeiro
authors: RR
authors: Castro
authors: Alana
authors: A
authors: de Freitas Pires
authors: Ana Maria Sampaio
authors: AM
authors: Assreuy
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001120:Arginine; D002351:Carrageenan; D002465:Cell Movement / Q000187:drug effects; D003911:Dextrans; D015232:Dinoprostone; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D010047:Ovalbumin; D037121:Plant Lectins / Q000627:therapeutic use*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D037121:Plant Lectins; D014409:Tumor Necrosis Factor-alpha; C039268:lectin, Canavalia; D002351:Carrageenan; D010047:Ovalbumin; D001120:Arginine; D015232:Dinoprostone
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