title: Insecticides biomarker responses on a freshwater fish Corydoras paleatus (Pisces: Callichthyidae).
abstract: This study was undertaken to investigate the effects of sublethal concentration of three different classes of insecticides (carbamate, organophosphate, and pyrethroid compounds) on the freshwater fish Corydoras paleatus. For this purpose, fish were exposed for 96 hours to commercial pesticides. Different biomarkers were analyzed as levels of lipid peroxidation (LPO), piscine micronucleus test, and enzymatic activities of catalase (CAT), glutathione S-transferase (GST), and acetylcholinesterase (AChE). The brain AChE was inhibited with carbaryl and methyl parathion, but no inhibition was observed with deltamethrin. The insecticides did not cause oxidative stress or genotoxic effects at the tested concentrations. Further studies are needed to elucidate the biotransformation of Corydoras paleatus insecticides and a possible resistance mechanism.
authors: Pharmacology Department, Federal University of Paraná, Curitiba-PR, Brazil.
authors: Izonete Cristina
authors: IC
authors: Guiloski
authors: Stéfani Cibele
authors: SC
authors: Rossi
authors: Cesar Aparecido
authors: CA
authors: da Silva
authors: Helena Cristina Silva
authors: HC
authors: de Assis
mesh_terms: D000110:Acetylcholinesterase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000032:analysis* / Q000378:metabolism; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D002397:Catfishes / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage / Q000187:drug effects; D004784:Environmental Monitoring; D029941:Fish Proteins / Q000235:genetics / Q000378:metabolism*; D005618:Fresh Water / Q000032:analysis; D007306:Insecticides / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D029941:Fish Proteins; D007306:Insecticides; D014874:Water Pollutants, Chemical; D002374:Catalase; D000110:Acetylcholinesterase