title: Improved stability and controlled release of ω3/ω6 polyunsaturated fatty acids by spring dextrin encapsulation.
abstract: Food grade biopolymers, such as dextrin, have been suggested as a technological solution for the controlled delivery of health promoting substances. The main focus of this work is to improve the stability of poly-unsaturated fatty acids (PUFAs) and controlled release by encapsulating with helical spring dextrin (SD). The encapsulation was formed between SD with a DP¯ of 62 and α-linolenic acid (ALA) or linoleic acid (LA) at 60 °C and characterized by WXRD, DSC, TGA and SEM. Under conditions which simulated the human environment of the gastrointestinal system, 21.7% and 18.5% of SD-ALA and SD-LA were released, respectively. A molecular dynamics simulation indicated that the space of helix cavity for ALA-SD complex was larger than that for LA-SD complex. This research work supports the idea that these complexes not only can improve the stability of ALA and LA, but also can achieve the targeted delivery of functional lipids or other bioactive components to the small intestine.
authors: School of Food Science and Technology, Jiangnan University, 1800 Lihu AVE, Wuxi 214122, People's Republic of China.
authors: Jin
authors: J
authors: Xu
authors: Wenxiu
authors: W
authors: Zhao
authors: Yawei
authors: Y
authors: Ning
authors: Mohanad
authors: M
authors: Bashari
authors: Fengfeng
authors: F
authors: Wu
authors: Haiying
authors: H
authors: Chen
authors: Na
authors: N
authors: Yang
authors: Zhengyu
authors: Z
authors: Jin
authors: Baocai
authors: B
authors: Xu
authors: Lixia
authors: L
authors: Zhang
authors: Xueming
authors: X
authors: Xu
mesh_terms: D002214:Capsules; D003692:Delayed-Action Preparations; D003912:Dextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D015525:Fatty Acids, Omega-3 / Q000737:chemistry*; D043371:Fatty Acids, Omega-6 / Q000737:chemistry*; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D000516:alpha-Amylases / Q000378:metabolism
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D003912:Dextrins; D004337:Drug Carriers; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D000516:alpha-Amylases