title: Imposex effects on the veined rapa whelk (Rapana venosa) in Bohai Bay, China.
abstract: Environmentally relevant concentrations of organotin compounds (OTs) may trigger sex changes in marine invertebrates and pose a threat to the marine ecosystem. In this study, we investigated organotin levels and the biological responses of wild veined rapa whelk (Rapana venosa) from Lüjuhe district (LJH), Dashentang district (DST), and Nanpaihe district (NPH) in Bohai Bay, China. We found that 11.11 and 22.95 % of the veined rapa whelks from DST and NPH exhibited imposex characteristics with a relative penis size index (RPSI) of 12.50 and 12.31, respectively. The RNA/DNA ratio was significantly lower in females from DST than those from LJH (p < 0.05), and a slight increase in DNA damage was observed in females and imposex individuals compared to males. Moreover, less genetic distance occurred between LJH and NPH (0.016) than between LJH and DST (0.028), although they belonged to the same regional population. OTs analysis showed that triphenyltin chloride concentrations (41.45 ng/g dried weight) were significantly higher than tributyltin concentrations (9.51 ng/g dried weight) in tissues (p < 0.05), but no significant differences were observed in sediments (p > 0.05). In conclusion, the occurrence of imposex individuals and biological responses of the wild veined rapa whelk from Bohai Bay suggest that the marine ecosystem might be at risk.
authors: State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy for Environment Sciences, Beijing, China.
authors: Li-hui
authors: LH
authors: An
authors: Yanqiang
authors: Y
authors: Zhang
authors: Shuang-shuang
authors: SS
authors: Song
authors: Yue
authors: Y
authors: Liu
authors: Zi-cheng
authors: ZC
authors: Li
authors: Hao
authors: H
authors: Chen
authors: Xing-ru
authors: XR
authors: Zhao
authors: Kun
authors: K
authors: Lei
authors: Junmin
authors: J
authors: Gao
authors: Bing-hui
authors: BH
authors: Zheng
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000187:drug effects; D002681:China; D004249:DNA Damage; D005260:Female; D049851:Gastropoda / Q000187:drug effects*; D008297:Male; D009947:Organotin Compounds / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects; D019849:Sex Determination Processes / Q000187:drug effects*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D009947:Organotin Compounds; D014874:Water Pollutants, Chemical
references: Nucleic Acids Res. 1995 Nov 11;23(21):4407-14
references: 7501463
references: Crit Rev Toxicol. 1996 Jan;26(1):1-117
references: 8833456
references: Environ Toxicol Chem. 2002 Mar;21(3):584-9
references: 11878471
references: Environ Sci Technol. 2006 Mar 1;40(5):1462-8
references: 16568757
references: Environ Pollut. 2005 Nov;138(2):307-15
references: 15951082
references: Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9339-44
references: 19470453
references: Aquat Toxicol. 2003 Dec 10;65(4):361-76
references: 14568352
references: Chemosphere. 2003 Jan;50(3):311-9
references: 12656250
references: Mar Pollut Bull. 2011 Apr;62(4):718-25
references: 21310441
references: Mar Environ Res. 2000 Jul-Dec;50(1-5):223-9
references: 11460694
references: Environ Sci Technol. 2005 Jul 1;39(13):4801-7
references: 16053077
references: Mar Pollut Bull. 2005 Apr;50(4):439-45
references: 15823306
references: Environ Int. 2007 Aug;33(6):817-22
references: 17499852
references: Mar Environ Res. 2007 Sep;64(3):384-98
references: 17459467
references: Ecotoxicol Environ Saf. 2008 Oct;71(2):473-82
references: 18358533
references: Mar Environ Res. 2001 Sep;52(3):213-29
references: 11570803
references: Mar Pollut Bull. 2005;51(8-12):811-6
references: 16054656
references: Arch Environ Contam Toxicol. 2004 Feb;46(2):208-15
references: 15106672
references: Environ Pollut. 2007 Mar;146(1):100-6
references: 16978749
references: Mar Pollut Bull. 2001 Jul;42(7):603-10
references: 11488241
references: Environ Toxicol Pharmacol. 2002 Jan;11(1):49-65
references: 21782586
references: Wei Sheng Yan Jiu. 2001 Jan;30(1):1-3
references: 11255750
references: Chemosphere. 2006 Nov;65(6):922-38
references: 16674992
references: Mutat Res. 1998 Mar 13;399(1):43-53
references: 9635488
references: Mutat Res. 2003 Aug 5;539(1-2):19-28
references: 12948811
references: Environ Health Perspect. 2006 Apr;114 Suppl 1:20-6
references: 16818242
references: Aquat Toxicol. 2001 Nov 1;55(1-2):61-73
references: 11551622
references: Environ Sci Technol. 2006 May 15;40(10):3142-7
references: 16749673
references: Water Res. 2002 Feb;36(4):905-18
references: 11848361
references: Environ Sci. 2006;13(2):77-87
references: 16788559
references: Mar Pollut Bull. 2002 Jun;44(6):534-43
references: 12146836
references: Aquat Toxicol. 2000 Aug 1;50(1-2):1-12
references: 10930646
references: Environ Int. 2007 Nov;33(8):1035-9
references: 17631965
references: Mar Environ Res. 2003 Mar;55(2):101-12
references: 12502033
references: Sci Total Environ. 2006 Aug 15;367(1):163-9
references: 16600332
references: Environ Health Perspect. 2006 Apr;114 Suppl 1:13-9
references: 16818241