title: Lipoxygenase: an emerging target for stroke therapy.
abstract: Neuroprotection as approach to stroke therapy has recently seen a revival of sorts, fueled in part by the continuing necessity to improve acute stroke care, and in part by the identification of novel drug targets. 12/15- Lipoxygenase (12/15-LOX), one of the key enzymes of the arachidonic acid cascade, contributes to both neuronal cell death and vascular injury. Inhibition of 12/15-LOX may thus provide multifactorial protection against ischemic injury. Targeting 12/15-LOX and related eicosanoid pathways is the subject of this brief review.
authors: Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, 149 13th St., R. 2401, Charlestown, MA 02129, USA. klaus_vanleyen@hms.harvard.edu
authors: Klaus
authors: K
authors: van Leyen
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008084:Lipoxygenase / Q000378:metabolism*; D008954:Models, Biological; D020521:Stroke / Q000188:drug therapy* / Q000201:enzymology* / Q000473:pathology
chemical_list: D004791:Enzyme Inhibitors; D016718:Arachidonic Acid; D008084:Lipoxygenase
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