title: Photothermal signal distribution analysis (PhoSDA).
abstract: Photothermal correlation spectroscopy (PhoCS) is a powerful counterpart to fluorescence correlation spectroscopy (FCS). Using PhoCS it is possible to probe the dynamics of non-fluorescent and non-bleaching ultra-stable metal-nanoparticles in solution and biological specimen, where they can be used as tracers and markers. This paper complements the absorption correlation method by a histogram analysis framework, the photothermal signal distribution analysis (PhoSDA). It is hereby possible to extract individual absorbent tracer concentrations, size dispersions, heterogeneous populations and focal geometry parameters which are otherwise inaccessible by correlation analysis.
authors: Universität Leipzig, Leipzig, Germany.
authors: Markus
authors: M
authors: Selmke
authors: Marco
authors: M
authors: Braun
authors: Romy
authors: R
authors: Schachoff
authors: Frank
authors: F
authors: Cichos
mesh_terms: D000042:Absorption; D053768:Metal Nanoparticles / Q000737:chemistry; D008962:Models, Theoretical; D013050:Spectrometry, Fluorescence; D013696:Temperature