title: Is there an association between platelet count during the first trimester and preeclampsia or other obstetric complications later in pregnancy?
abstract: OBJECTIVE
  To examine whether an association exists between platelet (PLT) count in the first trimester of pregnancy and the risk for hypertensive disorders or other obstetric complications.
  
  
  METHODS
  The study population included all registered births with available PLT count from the first trimester of pregnancy during 2000-2010. Thrombocytopenia was defined as PLT count below 100,000/μL. A comparison was performed between women with and without thrombocytopenia. Multiple logistic regression models were used to control for confounders.
  
  
  RESULTS
  The study population included 33,890 deliveries; of these, 119 (0.35%) were with thrombocytopenia. Women with thrombocytopenia had significantly higher rates of preterm delivery (16.0% vs. 9.4%; p = 0.015). There was no significant difference between the groups regarding hypertensive disorders.
  
  
  CONCLUSIONS
  Hypertensive disorders cannot be predicted based on PLT count during the first trimester of pregnancy. Nevertheless, thrombocytopenia during the first trimester is a risk factor for preterm delivery.
authors: Department of Obstetrics & Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. tzort@bgu.ac.il
authors: Tamar
authors: T
authors: Tzur
authors: Eyal
authors: E
authors: Sheiner
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016015:Logistic Models; D010976:Platelet Count; D011225:Pre-Eclampsia / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D047928:Premature Birth / Q000097:blood / Q000209:etiology*; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications*; D055815:Young Adult