title: Antimicrobial metallopeptides with broad nuclease and ribonuclease activity.
abstract: Metallopeptides containing both the complex Cu(2+)-glycyl-glycyl-histidine (Cu-GGH) and the sequence WRWYCR were shown to possess antimicrobial activity against a variety of pathogenic bacteria, as well as bind to and cleave a variety of nucleic acids, suggesting potential mechanisms for antimicrobial activity that involve binding and/or irreversible cleavage of bacterial nucleic acids.
authors: Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA. cowan@chemistry.ohio-state.edu
authors: Jeff C
authors: JC
authors: Joyner
authors: W F
authors: WF
authors: Hodnick
authors: Ada S
authors: AS
authors: Cowan
authors: Deepika
authors: D
authors: Tamuly
authors: Rachel
authors: R
authors: Boyd
authors: J A
authors: JA
authors: Cowan
mesh_terms: D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D012313:RNA / Q000378:metabolism; D012260:Ribonucleases / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D009842:Oligopeptides; D010455:Peptides; D012313:RNA; C037026:diglycyl-histidine; D003300:Copper; D004247:DNA; D003851:Deoxyribonucleases; D012260:Ribonucleases
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