title: Extents of white matter lesions and increased intraventricular extension of intracerebral hemorrhage.
abstract: OBJECTIVE
  To determine whether the extent of white matter lesions on a CT scan of acute intracerebral hemorrhage patients is associated with the prevalence and severity of intraventricular extension of hemorrhage.
  
  
  METHODS
  A post hoc analysis of Acute Brain Bleeding Analysis-IntraCerebral Hemorrhage cohort, a nationwide prospective cohort of acute intracerebral hemorrhage patients (total number of cohort subjects, 1,604).
  
  
  METHODS
  Spontaneous intracerebral hemorrhage patients (n = 1,262).
  
  
  METHODS
  None.
  
  
  METHODS
  The authors analyzed CT scan images taken within 48 hours after stroke onset. Extent of white matter lesions, volume of intracerebral hemorrhage, presence of intraventricular extension of hemorrhage, and intraventricular extension of hemorrhage score (approximation of intraventricular extension of hemorrhage volume) were measured using CT scans, and demographic, laboratory, clinical, and mortality data were also gathered through review of medical records and retrieval from the governmental statistical archive.
  
  
  RESULTS
  The frequency of intraventricular extension of hemorrhage in our population was 27.2% (343 subjects). The proportion of extensive white matter lesions in intraventricular extension of hemorrhage subjects (33.8%) was higher than that of non-intraventricular extension of hemorrhage cases (16.3%; p < 0.01). Multivariable analysis showed that mild (odds ratio, 1.48; 95% confidence interval 1.05- 0.09; p < 0.01) and extensive (odds ratio, 2.73; 95% confidence interval 1.88-3.98; p < 0.01) white matter lesions were significantly associated with the presence of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage patients. The estimated mean of the intraventricular extension of hemorrhage score from the extensive white matter lesions group (9.09 ± 0.76) was significantly higher than that of the no white matter lesions group (6.72 ± 0.78; p < 0.01 from analyses of covariances) after adjustment for relevant covariates.
  
  
  CONCLUSIONS
  We documented that the severity of white matter lesions is related to the occurrence and amount of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage cases.
authors: Department of Neurology and Stroke Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.
authors: Beom Joon
authors: BJ
authors: Kim
authors: Seung-Hoon
authors: SH
authors: Lee
authors: Wi-Sun
authors: WS
authors: Ryu
authors: Chi Kyung
authors: CK
authors: Kim
authors: Jong-Won
authors: JW
authors: Chung
authors: Dohoung
authors: D
authors: Kim
authors: Hong-Kyun
authors: HK
authors: Park
authors: Byung-Woo
authors: BW
authors: Yoon
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology*; D014695:Cerebral Ventriculography / Q000379:methods; D015331:Cohort Studies; D016001:Confidence Intervals; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D020521:Stroke / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*