title: Cell-death-associated molecular patterns as determinants of cancer immunogenicity.
abstract: CONCLUSIONS
  Accumulating evidence indicates that the success of some anticancer treatments (select chemotherapies or radiotherapy or trastuzumab) could be related to the stimulation of an anticancer immune response through the induction of an immunogenic tumor cell death (ICD).
  
  
  BACKGROUND
  Preclinical data revealed that dying tumor cells can emit a series of danger signals (so-called "cell-death-associated molecular patterns" (CDAMP)) that will dictate the recruitment and activation of specific inflammatory phagocytes. Hence, tumor cells succumbing to ICD are characterized by specific metabolic and molecular changes that will trigger a hierarchy of polarizing cytokine-producing cells, culminating in the recruitment and reactivation of antitumor interferon-γ-producing effector T cells which contribute to the success of cytotoxic treatments.
  
  
  RESULTS
  In this review, we summarize the molecular and cellular bases of this ICD, underscoring the crucial role of high mobility group box 1 protein (HMGB1) and adenosine tri-phosphate, both of which are released from dying tumor cells during ICD and are implicated in the chemotherapy-elicited anticancer immune response.
  
  
  CONCLUSIONS
  We discuss here how such CDAMP could serve as predictive biomarkers that could discriminate immunogenic from nonimmunogenic anti-cancer compounds, and, in case of deficiency, could be compensated by surrogate products to ameliorate the success rate of conventional anticancer treatment modalities.
authors: 1 Institut National de la Santé et de la Recherche Médicale , Villejuif, France .
authors: Sylvain
authors: S
authors: Ladoire
authors: Dalil
authors: D
authors: Hannani
authors: Marie
authors: M
authors: Vetizou
authors: Clara
authors: C
authors: Locher
authors: Laetitia
authors: L
authors: Aymeric
authors: Lionel
authors: L
authors: Apetoh
authors: Oliver
authors: O
authors: Kepp
authors: Guido
authors: G
authors: Kroemer
authors: François
authors: F
authors: Ghiringhelli
authors: Laurence
authors: L
authors: Zitvogel
mesh_terms: D000818:Animals; D016923:Cell Death / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D024243:HMGB1 Protein / Q000276:immunology; D006801:Humans; D009369:Neoplasms / Q000276:immunology*
chemical_list: D016207:Cytokines; D024243:HMGB1 Protein