title: Organization and segregation of bacterial chromosomes.
abstract: The bacterial chromosome must be compacted more than 1,000-fold to fit into the compartment in which it resides. How it is condensed, organized and ultimately segregated has been a puzzle for over half a century. Recent advances in live-cell imaging and genome-scale analyses have led to new insights into these problems. We argue that the key feature of compaction is the orderly folding of DNA along adjacent segments and that this organization provides easy and efficient access for protein-DNA transactions and has a central role in driving segregation. Similar principles and common proteins are used in eukaryotes to condense and to resolve sister chromatids at metaphase.
authors: Harvard Medical School, Department of Microbiology and Immunobiology, HIM 1025, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
authors: Xindan
authors: X
authors: Wang
authors: Paula
authors: P
authors: Montero Llopis
authors: David Z
authors: DZ
authors: Rudner
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002842:Chromatids; D020090:Chromosome Segregation; D002876:Chromosomes, Bacterial / Q000737:chemistry* / Q000235:genetics*; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics* / Q000302:isolation & purification; D008677:Metaphase; D009690:Nucleic Acid Conformation; D011487:Protein Conformation
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial
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