title: Beta-cell regeneration in human pancreas: the lessons of pancreatic pathology.
abstract: Diabetes mellitus has been traditionally classified as Type 1 and Type 2 on the basis of several criteria that generally reflect either insulin deficiency or functional defects in insulin secretion. In this chapter, we propose a new classification diabetes based on age of onset, body mass index and biomarkers such as islet autoantibodies and DR HLA alleles. In the second part of this chapter, we briefly discuss some novel hypotheses on the possibility of beta-cell regeneration in diabetes in relation to the islet pathology of the disease.
authors: The Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Denver, Colorado, USA.
authors: Matthew
authors: M
authors: Maulis
authors: Roberto
authors: R
authors: Gianani
mesh_terms: D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000145:classification* / Q000473:pathology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000145:classification* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*
chemical_list: D000682:Amyloid; D015415:Biomarkers