title: NMDA receptor antagonism with MK-801 impairs consolidation and reconsolidation of passive avoidance conditioning in adolescent rats: evidence for a state dependent reconsolidation effect.
abstract: The characteristics of memory consolidation, reconsolidation, and state dependency have received considerable attention for many years. Three experiments examined the effects of the NMDA antagonist MK-801 on these phenomena in adolescent rats using passive avoidance conditioning. Experiment 1 demonstrated that immediate post-training administration of MK-801 produced a consolidation impairment at postnatal day 37. Experiment 2 extended this result, showing that MK-801 administered immediately following memory reactivation disrupted reconsolidation. Experiment 3 employed a state dependent reconsolidation design, where saline or MK-801 was administered immediately following memory reactivation, and again 20 min prior to the retention test. Retention by the training/testing matched groups (saline/saline and MK-801/MK-801) was comparable and better than the mismatched groups (saline/MK-801 and MK-801/saline) providing evidence of state dependency. These results extend the consolidation/reconsolidation literature to adolescent animals and provide evidence that some deficits described as reconsolidation impairments may be more aptly considered state dependent retention deficits.
authors: The College of Saint Rose,Department of Psycholog, Albany, NY 12203-1490, USA. flintr@strose.edu
authors: Robert W
authors: RW
authors: Flint
authors: Lindsey J
authors: LJ
authors: Noble
authors: Adam R
authors: AR
authors: Ulmen
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012153:Retention, Psychology / Q000187:drug effects
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate