title: Haematological parameters and recurrent aphthous stomatitis.
abstract: OBJECTIVE
  To find out the relationship between recurrent aphthous stomatitis (RAS) with deficiencies of haemoglobin, haematocrit, serum vitamin B12, serum Ferritin and red blood cells (RBC) Folate level.
  
  
  METHODS
  An analytical cross-sectional study.
  
  
  METHODS
  Department of Oral Health Sciences, Shaikh Zayed Federal Postgraduate Medical Complex, Lahore, from February to July 2008.
  
  
  METHODS
  Sixty consecutive subjects with active RAS were taken as the aphthous group; 60 age and gender matched subjects without RAS were as the Non-Aphthous group. Five milliliter blood was taken from both groups to evaluate the levels of serum B12, and RBC Folate through radio immuno assay and serum ferritin with enzyme linked immuno-sorbent assay tests. Complete blood count was carried out to determine the level of haemoglobin and haematocrit in both groups. Proportion of subjects with lower values was compared using 2 text of proportions with significance at p < 0.05.
  
  
  RESULTS
  Serum Ferritin (p = 0.001), haematocrit (p < 0.001), RBC Folate (p < 0.001) and serum B12 (p < 0.001) were significantly lower in the RAS group. Combined deficiency state (haemoglobin, serum Ferritin, haematocrit, RBC Folate and serum B12) was identified in 13% (n = 8) RAS patients.
  
  
  CONCLUSIONS
  Frequency of haematinic deficiencies was high in RAS patients. Serum B12 and RBC Folate were significantly low in aphthous group.
authors: Department of Oral Pathology, Dental Section, Bolan Medical College, Quetta. nabihasaeed@hotmail.com
authors: Nabiha Farasat
authors: NF
authors: Khan
authors: Mohammad
authors: M
authors: Saeed
authors: Saima
authors: S
authors: Chaudhary
authors: Nabiha Farasat
authors: NF
authors: Khan
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005293:Ferritins / Q000097:blood*; D005492:Folic Acid / Q000097:blood*; D005494:Folic Acid Deficiency / Q000150:complications; D006400:Hematocrit / Q000379:methods; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000097:blood* / Q000503:physiopathology; D014805:Vitamin B 12 / Q000097:blood*; D014806:Vitamin B 12 Deficiency / Q000150:complications; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D005293:Ferritins; D005492:Folic Acid; D014805:Vitamin B 12