title: [Hyperthyroidism].
abstract: Thyrotoxicosis is mainly caused by autonomous adenomas of the thyroid gland and by Graves' disease. A less frequent cause for thyrotoxicosis is Hashimoto's thyroiditis. Thyrotoxicosis in autonomous adenomas and Graves' disease is caused by an increased thyroid hormone production whereas hyperthyroidism in Hashimoto's thyroiditis results from destruction of the thyroid gland. Drug therapy depends on the cause of the disease. Autonomous adenomas and Graves' disease are treated with methimazole and potentially with β-blockers. Regarding thyroid ablative therapy, radioiodine is mostly preferred compared to thyroidectomy. Drug therapy of Hashimoto's thyroiditis is purely symptomatic using β-blockers and rarely corticosteroids. Hyperthyroidism in pregnancy is a major issue and pregnant women in the first trimester are treated with propylthiouracil (PTU) whereas women in the second and third trimesters are treated with methimazole. The aim is to maintain the serum fT4 levels within the upper normal range.
authors: Funktionsbereich Endokrinologie, Klinik für Endokrinologie und Diabetologie, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland. matthias.schott@med.uni-duesseldorf.de
authors: M
authors: M
authors: Schott
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis* / Q000628:therapy*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008713:Methimazole / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000628:therapy; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D011878:Radiotherapy / Q000379:methods*
chemical_list: D000319:Adrenergic beta-Antagonists; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D008713:Methimazole
references: Clin Endocrinol (Oxf). 2009 Oct;71(4):566-73
references: 19170704
references: Clin Invest Med. 2005 Jun;28(3):127-31
references: 16021986
references: J Clin Endocrinol Metab. 2010 May;95(5):2123-31
references: 20237164
references: Clin Endocrinol (Oxf). 2006 Oct;65(4):433-8
references: 16984234
references: Eur J Endocrinol. 2008 Jan;158(1):69-75
references: 18166819
references: J Clin Endocrinol Metab. 2002 Feb;87(2):489-99
references: 11836274
references: J Clin Endocrinol Metab. 2001 Jun;86(6):2494-8
references: 11397845
references: Horm Metab Res. 2004 Feb;36(2):92-6
references: 15002058
references: J Clin Endocrinol Metab. 2010 Nov;95(11):E337-41
references: 20668039
references: Thyroid. 2005 Sep;15(9):1047-54
references: 16187913
references: Clin Endocrinol (Oxf). 2008 Nov;69(5):812-8
references: 18410546
references: World J Surg. 2012 Aug;36(8):1943-6
references: 22547016
references: J Clin Endocrinol Metab. 2012 Jul;97(7):E1080-7
references: 22492869
references: Autoimmun Rev. 2010 Aug;9(10):695-700
references: 20594972
references: J Clin Endocrinol Metab. 2010 Jul;95(7):3260-7
references: 20427502
references: J Clin Endocrinol Metab. 2006 Sep;91(9):3464-70
references: 16835285
references: Med Klin (Munich). 2009 May 15;104(5):343-8
references: 19444414
references: Endocrinology. 2010 Jul;151(7):3454-9
references: 20427476
references: J Clin Endocrinol Metab. 2012 Apr;97(4):1347-54
references: 22259066
references: J Clin Endocrinol Metab. 2012 Feb;97(2):499-506
references: 22130792