title: D18S880 microsatellite polymorphism of carnosinase gene and diabetic nephropathy: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to determine whether the CNDP1 (carnosinase gene) D18S880 microsatellite polymorphism confers susceptibility to diabetic nephropathy (DN).
  
  
  METHODS
  The authors conducted meta-analysis on association between the CNDP1 D18S880 microsatellite polymorphism and DN susceptibility, using fixed and random effects models.
  
  
  RESULTS
  A total of nine comparative studies were included in this meta-analysis, which included 4546 DN, 7994 diabetes mellitus (DM), and 1826 healthy (Heal) subjects. Overall, the analysis revealed that the D18S880 microsatellite polymorphism was significantly associated with DN for the five trinucleotide repeat (5L) allele and five leucines repeat (5L-5L) homozygous in the comparisons of DN versus DM (5L: odds ratio [OR] 0.90, 95% confidence interval [CI] 0.84-0.97, p=0.008; 5L-5L: OR 0.88, 95% CI 0.81-0.97, p=0.006) and DN versus non-DN (DM+Heal) (5L: OR 0.92, 95% CI 0.86-0.98, p=0.009; 5L-5L: OR 0.89, 95% CI 0.82-0.96, p=0.004). The protective effects of the D18S880 polymorphism were similar to those observed in the subgroups of the type 2 DM and the Caucasian population. However, significant association was not found in the type 1 DM population.
  
  
  CONCLUSIONS
  This meta-analysis confirms that the carnosinase D18S880 microsatellite polymorphism is associated with DN susceptibility, especially in the type 2 DM and the Caucasian population.
authors: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, People's Republic of China.
authors: Ji-Min
authors: JM
authors: Zhu
authors: Bin
authors: B
authors: Wang
authors: Jing
authors: J
authors: Li
authors: Gui-Mei
authors: GM
authors: Chen
authors: Yin-Guang
authors: YG
authors: Fan
authors: Chen-Chen
authors: CC
authors: Feng
authors: Hai-Feng
authors: HF
authors: Pan
authors: Dong-Qing
authors: DQ
authors: Ye
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000235:genetics*; D004150:Dipeptidases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
chemical_list: C522928:CNDP1 protein, human; D004150:Dipeptidases