title: Recapitulation of previous genome-wide association studies with two distinct pathophysiological entities of gastric cancer in the Korean population.
abstract: Gastric cancer (GC) is the most common malignancy. The incidence rates remain remarkably high in East Asians. Although genome-wide association studies in the Han Chinese and Japanese populations have so far yielded susceptibility loci for GC, these findings need to be validated in an independent ethnic group. To identify the potential heterogeneity by histological classified subtypes (intestinal and diffuse), we examined the previously reported associations in the Korean population. PRKAA1 at 5p13.1 was found to be more strongly associated with intestinal type (odds ratio, OR=1.39, 95% CI (confidence interval) =1.22-1.58, P=3.77 × 10(-7)) than diffuse type. In addition, PSCA at 8q23.3 was significantly replicated in diffuse type (OR=1.49, 95% CI=1.32-1.67, P=2.43 × 10(-11)) but far less significant in intestinal type. In conclusion, these findings could bring additional insights into the etiologic heterogeneity in gastric carcinogenesis mechanisms.
authors: Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
authors: Joo-Yeon
authors: JY
authors: Hwang
authors: Duk-Hwan
authors: DH
authors: Kim
authors: Yong-Ick
authors: YI
authors: Ji
authors: Min
authors: M
authors: Jin Go
authors: Lyong
authors: L
authors: Heo
authors: Young
authors: Y
authors: Jin Kim
authors: Tae
authors: T
authors: Sung Sohn
authors: Jae
authors: J
authors: Hyung Noh
authors: Sung
authors: S
authors: Kim
authors: Yeon-Su
authors: YS
authors: Lee
authors: Sook-Young
authors: SY
authors: Kim
authors: Young-Woo
authors: YW
authors: Kim
authors: Keun
authors: K
authors: Won Ryu
authors: Il Ju
authors: IJ
authors: Choi
authors: Juyoung
authors: J
authors: Lee
authors: Bong-Jo
authors: BJ
authors: Kim
authors: Bok-Ghee
authors: BG
authors: Han
authors: Joobae
authors: J
authors: Park
authors: Jong-Young
authors: JY
authors: Lee
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D013274:Stomach Neoplasms / Q000235:genetics*