title: Interleukin-13 genetic variants, household carpet use and childhood asthma.
abstract: Interleukin (IL)-13 genetic polymorphisms have shown adverse effects on respiratory health. However, few studies have explored the interactive effects between IL-13 haplotypes and environmental exposures on childhood asthma. The aims of our study are to evaluate the effects of IL-13 genetic variants on asthma phenotypes, and explore the potential interaction between IL-13 and household environmental exposures among Taiwanese children. We investigated 3,577 children in the Taiwan Children Health Study from 14 Taiwanese communities. Data regarding children's exposure and disease status were obtained from parents using a structured questionnaire. Four SNPs were tagged accounting for 100% of the variations in IL-13. Multiple logistic regression models with false-discovery rate (FDR) adjustments were fitted to estimate the effects of IL-13 variants on asthma phenotypes. SNP rs1800925, SNP rs20541 and SNP rs848 were significantly associated with increased risks on childhood wheeze with FDR of 0.03, 0.04 and 0.04, respectively. Children carrying two copies of h1011 haplotype showed increased susceptibility to wheeze. Compared to those without carpet use and h1011 haplotype, children carrying h1011 haplotype and using carpet at home had significantly synergistic risks of wheeze (OR, 2.5; 95% CI, 1.4-4.4; p for interaction, 0.01) and late-onset asthma (OR, 4.7; 95% CI, 2.0-10.9; p for interaction, 0.02). In conclusions, IL-13 genetic variants showed significant adverse effects on asthma phenotypes among children. The results also suggested that asthma pathogenesis might be mediated by household carpet use.
authors: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors: Ching-Hui
authors: CH
authors: Tsai
authors: Kuan-Yen
authors: KY
authors: Tung
authors: Ming-Wei
authors: MW
authors: Su
authors: Bor-Luen
authors: BL
authors: Chiang
authors: Fook Tim
authors: FT
authors: Chew
authors: Nai-Wei
authors: NW
authors: Kuo
authors: Yungling Leo
authors: YL
authors: Lee
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D002648:Child; D004391:Dust / Q000276:immunology; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D005430:Floors and Floorcoverings; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics* / Q000276:immunology; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D012119:Respiration / Q000235:genetics*; D011795:Surveys and Questionnaires; D013624:Taiwan; D014028:Tobacco Smoke Pollution
chemical_list: D004391:Dust; D018793:Interleukin-13; D014028:Tobacco Smoke Pollution
references: Chest. 2010 Oct;138(4):956-64
references: 20299625
references: Am J Hum Genet. 2004 Jan;74(1):106-20
references: 14681826
references: J Allergy Clin Immunol. 2000 Mar;105(3):506-13
references: 10719301
references: Allergy Asthma Clin Immunol. 2010 Apr 20;6(1):6
references: 20403202
references: Pediatr Allergy Immunol. 1994;5(6 Suppl):7-12
references: 7728232
references: Nature. 1985 Dec 12-18;318(6046):577-9
references: 3840867
references: Int J Hyg Environ Health. 2011 Dec;215(1):19-25
references: 21835690
references: Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):1805-11
references: 8520740
references: Allergy. 2010 May;65(5):623-9
references: 19860789
references: Genes Immun. 1999 Sep;1(1):61-5
references: 11197307
references: Genet Epidemiol. 2002 Nov;23(4):335-48
references: 12432502
references: Pediatr Allergy Immunol. 2005 Mar;16(2):157-64
references: 15787874
references: Science. 1998 Dec 18;282(5397):2261-3
references: 9856950
references: Respir Med. 2009 Feb;103(2):284-8
references: 18815020
references: J Allergy Clin Immunol. 2003 Oct;112(4):735-9
references: 14564352
references: Science. 1998 Dec 18;282(5397):2258-61
references: 9856949
references: J Allergy Clin Immunol. 2007 Jul;120(1):84-90
references: 17561245
references: Science. 2002 Jun 21;296(5576):2225-9
references: 12029063
references: J Occup Environ Hyg. 2009 Sep;6(9):582-91
references: 19585331
references: Occup Environ Med. 2011 Oct;68(10):771-6
references: 21307151
references: J Allergy Clin Immunol. 2008 Jul;122(1):93-8, 98.e1-5
references: 18440625
references: Respir Res. 2008 Jan 10;9:2
references: 18186920
references: Eur J Immunogenet. 2003 Oct;30(5):355-9
references: 14641544
references: Eur Respir J. 2011 Jun;37(6):1371-7
references: 21109554
references: Allergy. 2002 Feb;57(2):137-42
references: 11929416
references: Curr Opin Pulm Med. 2003 Jan;9(1):21-7
references: 12476080
references: J Hum Genet. 2006;51(12):1055-1062
references: 17006604
references: Am J Respir Crit Care Med. 1995 Jun;151(6):1786-93
references: 7767521
references: Nat Rev Genet. 2006 Oct;7(10):781-91
references: 16983374
references: Respir Res. 2010 Jan 29;11:11
references: 20113468
references: J Immunol. 2006 Dec 15;177(12):8633-42
references: 17142763
references: Nat Genet. 2005 Nov;37(11):1217-23
references: 16244653
references: N Engl J Med. 2001 Feb 1;344(5):350-62
references: 11172168
references: Allergy. 2008 Jul;63(7):857-64
references: 18588551
references: Environ Health Perspect. 2001 Aug;109(8):815-9
references: 11564617
references: Am J Epidemiol. 1995 Dec 15;142(12):1255-64
references: 7503045
references: J Epidemiol Community Health. 1998 Jun;52(6):359-63
references: 9764256
references: Pediatr Allergy Immunol. 2009 Nov;20(7):614-23
references: 19674346
references: Hum Hered. 2003;55(4):179-90
references: 14566096
references: N Engl J Med. 1990 Aug 23;323(8):502-7
references: 2377175
references: J Clin Invest. 1999 Mar;103(6):779-88
references: 10079098
references: Ann Epidemiol. 2001 Jan;11(1):38-45
references: 11164118
references: J Pediatr. 2001 Aug;139(2):278-83
references: 11487757
references: Allergy. 2003 Jul;58(7):572-9
references: 12823113
references: J Allergy Clin Immunol. 2002 Jun;109(6):980-7
references: 12063528
references: Proc Am Thorac Soc. 2007 Jan;4(1):26-31
references: 17202288