title: Benefits of a clinical data warehouse with data mining tools to collect data for a radiotherapy trial.
abstract: BACKGROUND
  Collecting trial data in a medical environment is at present mostly performed manually and therefore time-consuming, prone to errors and often incomplete with the complex data considered. Faster and more accurate methods are needed to improve the data quality and to shorten data collection times where information is often scattered over multiple data sources. The purpose of this study is to investigate the possible benefit of modern data warehouse technology in the radiation oncology field.
  
  
  METHODS
  In this study, a Computer Aided Theragnostics (CAT) data warehouse combined with automated tools for feature extraction was benchmarked against the regular manual data-collection processes. Two sets of clinical parameters were compiled for non-small cell lung cancer (NSCLC) and rectal cancer, using 27 patients per disease. Data collection times and inconsistencies were compared between the manual and the automated extraction method.
  
  
  RESULTS
  The average time per case to collect the NSCLC data manually was 10.4 ± 2.1 min and 4.3 ± 1.1 min when using the automated method (p<0.001). For rectal cancer, these times were 13.5 ± 4.1 and 6.8 ± 2.4 min, respectively (p<0.001). In 3.2% of the data collected for NSCLC and 5.3% for rectal cancer, there was a discrepancy between the manual and automated method.
  
  
  CONCLUSIONS
  Aggregating multiple data sources in a data warehouse combined with tools for extraction of relevant parameters is beneficial for data collection times and offers the ability to improve data quality. The initial investments in digitizing the data are expected to be compensated due to the flexibility of the data analysis. Furthermore, successive investigations can easily select trial candidates and extract new parameters from the existing databases.
authors: Department of Radiation Oncology (MAASTRO Clinic), Maastricht University Medical Centre (MUMC+), The Netherlands. erik.roelofs@maastro.nl
authors: Erik
authors: E
authors: Roelofs
authors: Lucas
authors: L
authors: Persoon
authors: Sebastiaan
authors: S
authors: Nijsten
authors: Wolfgang
authors: W
authors: Wiessler
authors: André
authors: A
authors: Dekker
authors: Philippe
authors: P
authors: Lambin
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D003625:Data Collection; D057225:Data Mining; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D012004:Rectal Neoplasms / Q000532:radiotherapy*
keywords: Clinical trials; Data quality; Data warehouse; Efficiency
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