title: Starch metabolism in Arabidopsis.
abstract: Starch is the major non-structural carbohydrate in plants. It serves as an important store of carbon that fuels plant metabolism and growth when they are unable to photosynthesise. This storage can be in leaves and other green tissues, where it is degraded during the night, or in heterotrophic tissues such as roots, seeds and tubers, where it is stored over longer time periods. Arabidopsis accumulates starch in many of its tissues, but mostly in its leaves during the day. It has proven to be a powerful genetic system for discovering how starch is synthesised and degraded, and new proteins and processes have been discovered. Such work has major significance for our starch crops, whose yield and quality could be improved by the application of this knowledge. Research into Arabidopsis starch metabolism has begun to reveal how its daily turnover is integrated into the rest of metabolism and adapted to the environmental conditions. Furthermore, Arabidopsis mutant lines deficient in starch metabolism have been employed as tools to study other biological processes ranging from sugar sensing to gravitropism and flowering time control. This review gives a detailed account of the use of Arabidopsis to study starch metabolism. It describes the major discoveries made and presents an overview of our understanding today, together with some as-yet unresolved questions.
authors: Institute of Agricultural Sciences, Department of Biology, ETH Zurich, Universitätstrasse 2, Zurich, Switzerland.
authors: Sebastian
authors: S
authors: Streb
authors: Samuel C
authors: SC
authors: Zeeman
references: Plant Physiol. 2008 Sep;148(1):65-76
references: 18614708
references: Biopolymers. 2009 Mar;91(3):179-93
references: 18985674
references: Plant Physiol Biochem. 2012 Sep;58:89-97
references: 22789914
references: Plant J. 2003 Apr;34(2):173-85
references: 12694593
references: Plant Physiol. 1991 Apr;95(4):1181-8
references: 16668109
references: Plant Cell. 1993 Nov;5(11):1555-1566
references: 12271046
references: BMC Plant Biol. 2008 Sep 23;8:96
references: 18811962
references: Cell. 1983 Nov;35(1):225-33
references: 6313224
references: Plant Cell. 1998 Mar;10(3):413-26
references: 9501114
references: Plant Physiol. 2001 Sep;127(1):252-61
references: 11553753
references: J Biol Chem. 1996 Feb 9;271(6):2902-8
references: 8621678
references: Plant Cell. 2004 Dec;16(12):3304-25
references: 15548738
references: Plant Physiol. 2001 Apr;125(4):1723-31
references: 11299353
references: Plant Physiol. 1991 Mar;95(3):890-5
references: 16668068
references: Plant Physiol. 2000 May;123(1):319-26
references: 10806248
references: Plant Physiol. 1979 Nov;64(5):749-53
references: 16661047
references: Proc Natl Acad Sci U S A. 2010 May 18;107(20):9458-63
references: 20439704
references: Plant Physiol. 1993 Apr;101(4):1201-1207
references: 12231774
references: Nature. 2007 Aug 23;448(7156):938-42
references: 17671505
references: Plant Physiol. 2006 Jul;141(3):879-86
references: 16698896
references: J Biol Chem. 2006 Apr 28;281(17):12050-9
references: 16495218
references: Biochem J. 2006 Jul 1;397(1):139-48
references: 16551270
references: Annu Rev Plant Physiol Plant Mol Biol. 1996 Jun;47:509-540
references: 15012299
references: Plant J. 2006 Oct;48(2):274-85
references: 17018036
references: Adv Space Res. 1999;24(6):755-62
references: 11542619
references: Plant Physiol. 2003 May;132(1):365-71
references: 12746541
references: Plant Physiol. 2010 Feb;152(2):711-22
references: 20018599
references: Genetics. 2008 Apr;178(4):2373-87
references: 18245855
references: Plant Mol Biol. 2003 Apr;51(6):949-58
references: 12777053
references: Curr Opin Plant Biol. 2010 Jun;13(3):321-9
references: 20171927
references: Plant Physiol. 2002 Jun;129(2):516-29
references: 12068097
references: Cell. 1990 Jan 12;60(1):115-22
references: 2153053
references: New Phytol. 2011 Apr;190(1):101-112
references: 21175634
references: Science. 2000 Dec 15;290(5499):2110-3
references: 11118138
references: Plant Physiol. 2003 Oct;133(2):838-49
references: 12972664
references: Plant Cell. 1998 Mar;10(3):399-412
references: 9501113
references: New Phytol. 2007;174(4):752-761
references: 17504459
references: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):765-70
references: 11149942
references: J Ultrastruct Res. 1979 Nov;69(2):249-61
references: 90736
references: Plant Physiol. 1999 Jan;119(1):267-76
references: 9880369
references: Biochem J. 1996 Dec 1;320 ( Pt 2):493-8
references: 8973558
references: Plant Cell. 2008 Dec;20(12):3448-66
references: 19074683
references: Plant Physiol. 2010 Sep;154(1):55-66
references: 20605913
references: Curr Opin Plant Biol. 2012 Jun;15(3):282-92
references: 22541711
references: Plant J. 2010 Mar;61(6):1067-91
references: 20409279
references: Annu Rev Pharmacol Toxicol. 2000;40:617-47
references: 10836149
references: J Biol Chem. 2003 Nov 7;278(45):44439-47
references: 12941966
references: Plant Physiol. 2002 Dec;130(4):1645-56
references: 12481048
references: Curr Opin Biotechnol. 2011 Apr;22(2):271-80
references: 21185717
references: BMC Plant Biol. 2008 Sep 30;8:98
references: 18826586
references: Plant Physiol. 1985 Sep;79(1):11-7
references: 16664354
references: Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9908-13
references: 19470473
references: FASEB J. 1988 Dec;2(15):3097-103
references: 2973423
references: Plant Cell. 2009 Aug;21(8):2443-57
references: 19666739
references: Biochim Biophys Acta. 1996 Dec 6;1291(3):221-7
references: 8980636
references: Plant Physiol. 2011 Apr;155(4):1723-34
references: 21115809
references: Plant Mol Biol. 2002 Feb 1;48(3):287-97
references: 11855730
references: Plant Physiol. 1999 Jan;119(1):255-66
references: 9880368
references: Mol Cell Biol. 1995 Dec;15(12):6632-40
references: 8524228
references: Plant Physiol. 2007 Sep;145(1):17-28
references: 17631522
references: Arch Biochem Biophys. 2002 Oct 1;406(1):21-32
references: 12234486
references: Arch Biochem Biophys. 1997 Jun 1;342(1):92-8
references: 9185617
references: Biochem Biophys Res Commun. 1961 Nov 1;6:85-8
references: 14490887
references: Plant Physiol. 1995 Nov;109(3):743-50
references: 8552713
references: Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1785-90
references: 15665090
references: Plant J. 2002 Jun;30(5):581-91
references: 12047632
references: Plant J. 2001 Apr;26(1):89-100
references: 11359613
references: Plant Cell Environ. 2007 Sep;30(9):1126-49
references: 17661751
references: FEBS Lett. 2003 Apr 24;541(1-3):137-44
references: 12706834
references: FEBS Lett. 2005 Jan 31;579(3):827-31
references: 15670855
references: Plant Physiol. 1987 Feb;83(2):399-407
references: 16665257
references: Annu Rev Plant Biol. 2003;54:207-33
references: 14502990
references: Plant Cell. 2008 Apr;20(4):1040-58
references: 18390594
references: Trends Plant Sci. 2010 Apr;15(4):236-40
references: 20149714
references: Plant Physiol. 2000 Feb;122(2):453-62
references: 10677438
references: Plant J. 2004 Mar;37(6):853-63
references: 14996213
references: Plant J. 2005 Dec;44(5):730-43
references: 16297066
references: FEBS Lett. 2006 Sep 4;580(20):4872-6
references: 16914145
references: Biosci Biotechnol Biochem. 2007 Sep;71(9):2308-12
references: 17827690
references: Eur J Biochem. 2001 Dec;268(23):6140-5
references: 11733008
references: Int J Plant Sci. 1999;160(3):521-7
references: 11542271
references: J Exp Bot. 2003 Jan;54(382):451-6
references: 12508055
references: Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11118-23
references: 16046541
references: Plant J. 2012 Apr;70(2):231-42
references: 22098298
references: Am J Bot. 2007 Apr;94(4):590-8
references: 21636428
references: Plant J. 1997 Apr;11(4):841-51
references: 9161039
references: Plant Physiol. 2005 Jan;137(1):43-56
references: 15618430
references: Plant J. 2005 Aug;43(3):398-412
references: 16045475
references: Plant Physiol. 1988 Nov;88(3):838-44
references: 16666394
references: Protoplasma. 1996;194:81-90
references: 11540605
references: Plant Cell. 2005 Mar;17(3):760-75
references: 15722468
references: Plant Physiol. 1983 Aug;72(4):1139-41
references: 16663136
references: Plant Cell. 2004 Mar;16(3):694-708
references: 14973170
references: Nat Biotechnol. 2000 May;18(5):551-4
references: 10802625
references: Cell. 1996 Aug 9;86(3):349-52
references: 8756717
references: Plant Physiol. 2010 Feb;152(2):685-97
references: 20018601
references: Plant J. 1998 Aug;15(3):357-65
references: 9750347
references: Plant Cell. 2003 Jan;15(1):133-49
references: 12509527
references: Plant Physiol. 1988 Apr;86(4):1131-5
references: 16666044
references: Plant J. 2005 Aug;43(4):568-85
references: 16098110
references: J Exp Bot. 2012 Feb;63(4):1593-608
references: 22291134
references: J Biol Chem. 1993 Jan 15;268(2):1391-6
references: 7678257
references: Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2215-20
references: 14766984
references: Plant J. 2008 Jul;55(2):323-34
references: 18419779
references: Plant Cell Environ. 2009 Jul;32(7):859-74
references: 19236606
references: Planta. 1998 Sep;206(1):131-7
references: 9715535
references: Plant Physiol. 2006 Jul;141(3):840-50
references: 16698902
references: Plant Cell Physiol. 2005 Aug;46(8):1366-76
references: 15951568
references: Planta. 2006 Dec;225(1):75-87
references: 16953433
references: Plant J. 2005 May;42(4):567-85
references: 15860015
references: BMC Plant Biol. 2008 Nov 27;8:120
references: 19038037
references: Plant Physiol. 2008 Apr;146(4):1878-91
references: 18263778
references: Plant Physiol. 2008 Apr;146(4):1892-908
references: 18281416
references: Int J Biol Macromol. 2000 Jun 13;27(3):211-8
references: 10828367
references: Crit Rev Biotechnol. 2009;29(3):214-24
references: 19708823
references: Biochem Soc Trans. 2007 Feb;35(Pt 1):28-32
references: 17212583
references: J Integr Plant Biol. 2010 Mar;52(3):273-88
references: 20377688
references: Plant Physiol. 2009 Dec;151(4):1769-72
references: 19776162
references: Plant Physiol. 2012 Feb;158(2):905-16
references: 22135430
references: Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10348-53
references: 19506259
references: Plant Physiol. 1990 Nov;94(3):1033-9
references: 16667793
references: Plant Cell. 2009 Jan;21(1):334-46
references: 19141707
references: Plant Physiol. 2011 May;156(1):61-77
references: 21436381
references: J Biol Chem. 1993 Jan 15;268(2):1081-6
references: 8380404
references: Annu Rev Plant Biol. 2005;56:187-220
references: 15862094
references: Arch Biochem Biophys. 2010 Mar 1;495(1):82-92
references: 20045390
references: Plant Cell. 2001 Aug;13(8):1907-18
references: 11487701
references: Plant J. 2004 Sep;39(6):933-46
references: 15341635
references: Antioxid Redox Signal. 2008 Jul;10(7):1235-74
references: 18377232
references: Plant Physiol. 1980 Jul;66(1):187-93
references: 16661385
references: Biomacromolecules. 2006 Aug;7(8):2310-20
references: 16903676
references: Plant Physiol. 2001 Mar;125(3):1396-405
references: 11244119
references: Plant Physiol. 2005 Jun;138(2):663-74
references: 15908598
references: J Biol Chem. 1998 Sep 25;273(39):25045-52
references: 9737961
references: Plant Physiol. 2006 Mar;140(3):1070-84
references: 16443699
references: Plant Physiol. 2011 Jun;156(2):803-15
references: 21474437
references: Plant J. 1999 Dec;20(5):519-27
references: 10652124
references: Trends Plant Sci. 2005 Mar;10(3):130-7
references: 15749471
references: Plant Physiol. 2010 Oct;154(2):643-55
references: 20699404
references: Plant Physiol. 1988 Dec;88(4):1175-81
references: 16666440
references: Plant Cell. 2005 Dec;17(12):3257-81
references: 16299223
references: Plant Cell Environ. 2007 Apr;30(4):388-98
references: 17324226
references: Plant Physiol. 2006 Nov;142(3):878-89
references: 16980562
references: Genome. 2003 Jun;46(3):496-506
references: 12834068
references: Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10659-63
references: 12960388
references: Plant Physiol. 2005 Jun;138(2):837-46
references: 15894744
references: Plant Physiol. 2001 Jun;126(2):883-9
references: 11402215
references: Plant J. 1999 Dec;20(5):581-90
references: 10652130
references: Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9732-7
references: 16772378
references: Plant Physiol. 2005 Jan;137(1):242-52
references: 15618411
references: Plant Physiol. 2004 Aug;135(4):2068-77
references: 15286293
references: Science. 2004 Jan 2;303(5654):87-9
references: 14704427
references: Plant Physiol. 2005 Aug;138(4):2280-91
references: 16055686
references: Proteomics. 2006 Mar;6(6):1886-96
references: 16470656
references: Plant Cell Physiol. 2005 Jun;46(6):858-69
references: 15821023
references: Funct Plant Biol. 2007 Jun;34(6):526-549
references: 32689382
references: Arabidopsis Book. 2010;8:e0133
references: 22303259
references: Arabidopsis Book. 2002;1:e0043
references: 22303208
references: Plant Physiol. 2009 Jun;150(2):962-76
references: 19395406
references: Plant Cell. 1995 Apr;7(4):417-29
references: 7773016
references: Mol Plant. 2009 Nov;2(6):1233-46
references: 19946617
references: Plant Physiol. 2009 Nov;151(3):1582-95
references: 19759345
references: Plant J. 2002 Dec;32(5):685-99
references: 12472685
references: Biochem J. 1999 May 15;340 ( Pt 1):183-91
references: 10229673
references: Planta. 1999 Apr;208(2):283-93
references: 10333591
references: Plant Physiol. 2003 May;132(1):137-45
references: 12746519
references: Crit Rev Biochem Mol Biol. 2000;35(3):141-96
references: 10907795
references: J Exp Bot. 2011 Aug;62(13):4547-59
references: 21624979
references: J Exp Bot. 2011 Jan;62(2):545-55
references: 20876336
references: Plant J. 2004 Sep;39(6):847-62
references: 15341628
references: Plant J. 2008 Oct;56(1):51-63
references: 18564385
references: Plant Cell. 2006 Oct;18(10):2694-709
references: 17028209
references: Plant J. 2007 Feb;49(3):492-504
references: 17217470
references: Plant Physiol. 2004 Jun;135(2):849-58
references: 15173560
references: Plant Cell. 2003 Mar;15(3):666-80
references: 12615940
references: Plant J. 2006 May;46(4):668-84
references: 16640603
references: BMC Genomics. 2010 Feb 05;11:93
references: 20137087
references: Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13124-9
references: 19470642
references: Mol Gen Genet. 2000 Jul;263(6):978-86
references: 10954083
references: Physiol Plant. 1996 Jun;97(2):237-44
references: 11539189
references: Genome Biol. 2006;7(8):R76
references: 16916443
references: Plant Physiol. 2009 Mar;149(3):1541-59
references: 19168640
references: Plant J. 2005 Mar;41(6):815-30
references: 15743447
references: Plant Physiol. 1984 Jul;75(3):554-60
references: 16663665
references: Biochem Genet. 1974 Feb;11(2):83-96
references: 4824506
references: J Biol Chem. 1993 Sep 5;268(25):19084-91
references: 8360192
references: Plant Cell. 1995 Oct;7(10):1703-1712
references: 12242359
references: Planta. 2008 Aug;228(3):411-25
references: 18481082
references: J Exp Bot. 2007;58(14):3949-60
references: 18024995
references: J Cell Biol. 2007 Jul 30;178(3):477-88
references: 17646401
references: Plant J. 2003 Aug;35(4):490-500
references: 12904211
references: Plant Physiol. 2005 May;138(1):184-95
references: 15849301
references: Proc Natl Acad Sci U S A. 2002 May 14;99(10):7166-71
references: 12011472
references: Plant J. 2005 Feb;41(4):595-605
references: 15686522
references: Plant Physiol. 1997 Jan;113(1):201-8
references: 9008395
references: J Biol Chem. 2005 Mar 4;280(9):8143-9
references: 15598655
references: J Biol Chem. 2003 Aug 1;278(31):28508-15
references: 12748181
references: Biochem J. 2007 Jan 1;401(1):13-28
references: 17150041
references: Planta. 2004 Jan;218(3):466-73
references: 14593480
references: Biopolymers. 1999 Oct 5;50(4):381-90
references: 10423547
references: Plant Cell. 2005 Aug;17(8):2255-70
references: 16006578
references: J Biol Chem. 1972 Jun 25;247(12):3822-8
references: 4624446
references: Plant Cell Physiol. 2010 May;51(5):776-94
references: 20305271
references: Plant Physiol. 2001 Dec;127(4):1798-807
references: 11743123
references: Plant Physiol. 2004 Sep;136(1):2687-99
references: 15347792
references: J Biol Chem. 2007 Aug 3;282(31):22481-91
references: 17562699
references: Plant Cell Physiol. 2009 Apr;50(4):904-8
references: 19282372
references: Plant Cell. 1998 Oct;10(10):1699-712
references: 9761796
references: J Agric Food Chem. 2008 Aug 27;56(16):7215-22
references: 18656938
references: J Exp Bot. 2011 Mar;62(6):1775-801
references: 21220783
references: Plant Physiol. 2005 Feb;137(2):756-61
references: 15665241
references: Plant Cell Physiol. 2012 Feb;53(2):433-44
references: 22210900
references: Plant Physiol. 1999 Aug;120(4):993-1004
references: 10444082
references: Plant Cell. 2008 Jul;20(7):1833-49
references: 18621947
references: Science. 1992 Oct 9;258(5080):287-92
references: 17835129
references: Plant Cell. 2011 Apr;23(4):1391-403
references: 21487098
references: J Biol Chem. 1998 Aug 28;273(35):22232-40
references: 9712837
references: Plant Cell. 2000 May;12(5):787-802
references: 10810150
references: J Biol Chem. 2006 Apr 28;281(17):11815-8
references: 16513634
references: Plant Cell Environ. 2006 Mar;29(3):353-66
references: 17080591
references: Nat Biotechnol. 1998 May;16(5):473-7
references: 9592398
references: Plant Cell. 2009 Sep;21(9):2844-58
references: 19767453
references: Plant Physiol. 2003 Nov;133(3):1111-21
references: 14526120
references: Plant Physiol. 2004 Oct;136(2):3333-40
references: 15448195
references: Plant J. 2009 Jan;57(1):1-13
references: 18764922
references: Plant Cell. 1996 Aug;8(8):1353-1366
references: 12239416
references: Biochem Biophys Res Commun. 1998 Jun 18;247(2):493-7
references: 9642157
references: Plant Physiol. 2000 Apr;122(4):989-97
references: 10759494
references: Plant Physiol. 2010 Jul;153(3):956-69
references: 20448101
references: J Biol Chem. 2005 Mar 18;280(11):9773-9
references: 15637061
references: Plant Physiol. 2011 Apr;155(4):1566-77
references: 21378102
references: Planta. 1991 Aug;185(1):17-26
references: 24186274
references: Int J Biol Macromol. 2007 Apr 10;40(5):449-60
references: 17188347
references: Annu Rev Plant Biol. 2010;61:209-34
references: 20192737
references: Plant J. 1995 Jan;7(1):3-15
references: 7894509
references: Plant Physiol. 2008 Nov;148(3):1309-23
references: 18815382
references: Plant J. 2002 Jul;31(1):97-112
references: 12100486
references: Plant Cell. 2011 Nov;23(11):4096-111
references: 22100529
references: New Phytol. 2010 Aug;187(3):791-804
references: 20546137
references: Plant Physiol. 2008 Apr;146(4):1834-61
references: 18305208
references: Plant J. 2010 Mar;61(6):1001-13
references: 20409274
references: Plant Physiol. 1988 Jan;86(1):260-5
references: 16665877
references: Plant Cell. 2004 Aug;16(8):2151-63
references: 15269330
references: Plant Physiol. 1985 Aug;78(4):753-7
references: 16664319