title: Recurrent abruptio placentae in a cynomolgus monkey (Macaca fascicularis).
abstract: BACKGROUND
  Abruptio placentae, defined as premature separation of a normally implanted placenta, is a life threatening pregnancy complication with unknown pathophysiology. A history of abruptio placentae is the major risk factor for this pregnancy complication in humans. We describe the first case of recurrent abruptio placentae in a Macaca fascicularis.
  
  
  METHODS
  A pregnant M. fascicularis at term gestation was presented with weakness and hypothermia. Cesarean section revealed retroplacental hemorrhage with partial placental separation from the uterus.
  
  
  RESULTS
  The weight of the female fetus was within the lower birth weight range for these species. The maternal side of placenta contained necrotic tissue, occupying approximately 60% of the maternal surface. The placental implantation bed demonstrated neutrophil infiltration. Perivascular collections of lymphocytes were noticed in the uterine smooth muscle.
  
  
  CONCLUSIONS
  This case report underlines the importance of neutrophil infiltration and uterine venous drainage in the cascade of events leading to abruptio placentae.
authors: Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN 38103-2896, USA. nschlabr@uthsc.edu
authors: N
authors: N
authors: Schlabritz-Loutsevitch
authors: G
authors: G
authors: Hubbard
authors: J
authors: J
authors: Zhang
authors: S
authors: S
authors: Gupta
authors: E
authors: E
authors: Dick
mesh_terms: D000037:Abruptio Placentae / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D002585:Cesarean Section; D005260:Female; D005313:Fetal Death / Q000209:etiology / Q000662:veterinary; D008252:Macaca fascicularis; D008992:Monkey Diseases; D020556:Neutrophil Infiltration; D011247:Pregnancy; D012008:Recurrence; D012307:Risk Factors
references: Am J Obstet Gynecol. 2007 Sep;197(3):319.e1-6
references: 17826437
references: Placenta. 2010 Jan;31(1):44-52
references: 19945160
references: Br J Obstet Gynaecol. 1997 Nov;104(11):1292-5
references: 9386031
references: Jpn J Med Sci Biol. 1978 Aug;31(4):365-9
references: 101705
references: Am J Obstet Gynecol. 1966 Jul 1;95(5):640-7
references: 5949477
references: BMC Genomics. 2011 Oct 16;12:509
references: 21999700
references: Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):762-70
references: 16150272
references: Pediatr Infect Dis J. 2006 Nov;25(11):1069-73
references: 17072133
references: Acta Obstet Gynecol Scand. 2011 Feb;90(2):140-9
references: 21241259
references: Postgrad Med. 1961 Nov;30:397-406
references: 13865438