title: Vasorelaxant prenylated flavonoids from the roots of Sophora flavescens.
abstract: Bioassay-guided fractionation of the methanol extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids responsible for the vasorelaxation activity in porcine coronary arteries. Among them, kushenol N and 5-methylsophoraflavanone B strongly induced the relaxation of porcine coronary arteries with respective ED(50) values of 8.6 and 12.4 µM. This activity and the results of a high-performance liquid chromatographic analysis suggest that kushenol N and 5-methylsophoraflavanone B could be active markers in the S. flavescens extract for vasorelaxation activity.
authors: College of Pharmacy, Hanyang University, Korea.
authors: Chul Young
authors: CY
authors: Kim
authors: Hyun Jung
authors: HJ
authors: Kim
authors: Kyeong-Man
authors: KM
authors: Kim
authors: Min-Ho
authors: MH
authors: Oak
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000494:pharmacology; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000432:Methanol; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D054876:Prenylation; D029909:Sophora / Q000737:chemistry*; D013552:Swine; D046509:Tissue Culture Techniques; D014661:Vasoconstriction; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000432:Methanol