title: Early social experience is critical for the development of cognitive control and dopamine modulation of prefrontal cortex function.
abstract: Social experiences during youth are thought to be critical for proper social and cognitive development. Conversely, social insults during development can cause long-lasting behavioral impairments and increase the vulnerability for psychopathology later in life. To investigate the importance of social experience during the juvenile and early adolescent stage for the development of cognitive control capacities, rats were socially isolated from postnatal day 21 to 42 followed by re-socialization until they reached adulthood. Subsequently, two behavioral dimensions of impulsivity (impulsive action in the five-choice serial reaction time task (5-CSRTT) and impulsive choice in the delayed reward task) and decision making (in the rat gambling task) were assessed. In a separate group of animals, long-lasting cellular and synaptic changes in adult medial prefrontal cortex (PFC) pyramidal neurons were determined following social isolation. Juvenile and early adolescent social isolation resulted in impairments in impulsive action and decision making under novel or challenging circumstances. Moreover, socially isolated rats had a reduced response to enhancement of dopaminergic neurotransmission (using amphetamine or GBR12909) in the 5-CSRTT under challenging conditions. Impulsive choice was not affected by social isolation. These behavioral deficits were accompanied by a loss of sensitivity to dopamine of pyramidal neurons in the medial PFC. Our data show long-lasting deleterious effects of early social isolation on cognitive control and its neural substrates. Alterations in prefrontal cognitive control mechanisms may contribute to the enhanced risk for psychiatric disorders induced by aberrations in the early social environment.
authors: Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Utrecht, The Netherlands.
authors: Petra J J
authors: PJ
authors: Baarendse
authors: Danielle S
authors: DS
authors: Counotte
authors: Patricio
authors: P
authors: O'Donnell
authors: Louk J M J
authors: LJ
authors: Vanderschuren
mesh_terms: D000367:Age Factors; D000818:Animals; D003071:Cognition / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D007175:Impulsive Behavior / Q000378:metabolism / Q000523:psychology; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time / Q000502:physiology; D012931:Social Environment; D012934:Social Isolation / Q000523:psychology*
chemical_list: D004298:Dopamine
references: Neuroscience. 1989;29(1):45-56
references: 2710347
references: Nat Rev Neurosci. 2008 Apr;9(4):267-77
references: 18354399
references: Biol Psychiatry. 2006 Jul 1;60(1):66-73
references: 16125144
references: J Comp Neurol. 1988 Mar 1;269(1):58-72
references: 3361004
references: Prog Neurobiol. 2004 Sep;74(1):1-58
references: 15381316
references: Cognition. 1994 Apr-Jun;50(1-3):7-15
references: 8039375
references: Behav Brain Res. 1989 Jun 1;33(2):165-79
references: 2504222
references: Curr Opin Psychiatry. 2007 May;20(3):255-61
references: 17415079
references: Neuropsychopharmacology. 2012 Jun;37(7):1656-70
references: 22334120
references: Psychopharmacology (Berl). 2002 Nov;164(3):329-40
references: 12424557
references: Neuropsychopharmacology. 2012 Aug;37(9):2057-66
references: 22510726
references: Psychopharmacology (Berl). 1996 Nov;128(2):161-70
references: 8956377
references: Neuropsychopharmacology. 2009 Sep;34(10):2329-43
references: 19536111
references: Psychopharmacology (Berl). 2006 Jul;187(1):73-85
references: 16767417
references: Psychopharmacology (Berl). 2002 Oct;163(3-4):362-80
references: 12373437
references: Annu Rev Neurosci. 2009;32:267-87
references: 19555290
references: Neurosci Biobehav Rev. 2000 Jun;24(4):417-63
references: 10817843
references: Q Rev Biol. 2001 Jun;76(2):141-68
references: 11409050
references: J Neurosci. 2009 Aug 12;29(32):9955-60
references: 19675229
references: Science. 2012 Sep 14;337(6100):1357-60
references: 22984073
references: Synapse. 2008 Mar;62(3):185-92
references: 18081181
references: J Neurosci. 2008 Nov 26;28(48):12691-9
references: 19036962
references: Psychol Med. 2005 Feb;35(2):163-74
references: 15841674
references: Trends Pharmacol Sci. 2010 Oct;31(10):463-9
references: 20684996
references: Psychopharmacology (Berl). 2007 Apr;191(3):587-98
references: 16972104
references: Dev Psychobiol. 1981 Jul;14(4):327-32
references: 7250521
references: Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):3-18
references: 12732219
references: Neuropsychopharmacology. 2002 Jun;26(6):716-28
references: 12007742
references: Neurosci Biobehav Rev. 1997 May;21(3):309-26
references: 9168267
references: J Neurosci. 1992 Sep;12(9):3609-18
references: 1527600
references: Neurosci Biobehav Rev. 2010 Jan;34(1):50-72
references: 19615404
references: Trends Cogn Sci. 2009 Oct;13(10):447-54
references: 19726219
references: Nat Rev Neurosci. 2008 Dec;9(12):947-57
references: 19002191
references: Eur J Neurosci. 2009 Mar;29(5):997-1014
references: 19291226
references: Trends Pharmacol Sci. 2008 Apr;29(4):192-9
references: 18304658
references: Eur J Neurosci. 2010 Nov;32(9):1452-60
references: 20950357
references: Psychopharmacology (Berl). 2013 Feb;225(3):719-31
references: 22968659
references: Neurosci Biobehav Rev. 2008 Aug;32(6):1087-102
references: 18423591
references: Trends Cogn Sci. 2005 Mar;9(3):104-10
references: 15737818
references: J Neurosci. 2008 Mar 5;28(10):2375-82
references: 18322084
references: Neuron. 2000 Feb;25(2):269-78
references: 10719884
references: Cereb Cortex. 2005 Jan;15(1):49-57
references: 15217899
references: Annu Rev Neurosci. 2001;24:167-202
references: 11283309
references: Am J Psychiatry. 2001 Nov;158(11):1783-93
references: 11691682
references: Psychopharmacology (Berl). 2012 Jan;219(2):313-26
references: 22134476
references: Dev Psychobiol. 1999 Mar;34(2):129-38
references: 10086231
references: Cereb Cortex. 2007 May;17(5):1235-40
references: 16818475