title: Increased peritoneal dialysis exit site infections using topical antiseptic polyhexamethylene biguanide compared to mupirocin: results of a safety interim analysis of an open-label prospective randomized study.
abstract: Prophylactic mupirocin for peritoneal catheter exit sites reduces exit site infection (ESI) risk but engenders antibiotic resistance. We present early interim safety analysis of an open-label randomized study comparing polyhexamethylene biguanide (PHMB) and mupirocin. A total of 106 patients randomized to 53 in each group were followed up for a mean of 12.68 months per patient. On safety analysis, the PHMB group had a significantly greater ESI rate than the mupirocin group (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.09 to 0.80), leading to discontinuation of the trial.
authors: Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, United Kingdom.
authors: Andrew
authors: A
authors: Findlay
authors: Charelle
authors: C
authors: Serrano
authors: Sally
authors: S
authors: Punzalan
authors: Stanley L
authors: SL
authors: Fan
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001645:Biguanides / Q000627:therapeutic use*; D002408:Catheters, Indwelling / Q000009:adverse effects / Q000382:microbiology; D057239:Early Termination of Clinical Trials; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016712:Mupirocin / Q000627:therapeutic use*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D013203:Staphylococcal Infections / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D016019:Survival Analysis
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D001645:Biguanides; C031233:polihexanide; D016712:Mupirocin
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