title: Toward modeling of radio-frequency ablation lesions for image-guided left atrial fibrillation therapy: model formulation and preliminary evaluation.
abstract: In the context of image-guided left atrial fibrillation therapy, relatively very little work has been done to consider the changes that occur in the tissue during ablation in order to monitor therapy delivery. Here we describe a technique to predict the lesion progression and monitor the radio-frequency energy delivery via a thermal ablation model that uses heat transfer principles to estimate the tissue temperature distribution and resulting lesion. A preliminary evaluation of the model was conducted in ex vivo skeletal beef muscle tissue while emulating a clinically relevant tissue ablation protocol. The predicted temperature distribution within the tissue was assessed against that measured directly using fiberoptic temperature probes and showed agreement within 5°C between the model-predicted and experimentally measured tissue temperatures at prescribed locations. We believe this technique is capable of providing reasonably accurate representations of the tissue response to radio-frequency energy delivery.
authors: Biomedical Imaging Resource, Mayo Clinic, Rochester, MN, USA. linte.cristian@mayo.edu
authors: Cristian A
authors: CA
authors: Linte
authors: Jon J
authors: JJ
authors: Camp
authors: David R
authors: DR
authors: Holmes
authors: Maryam E
authors: ME
authors: Rettmann
authors: Douglas L
authors: DL
authors: Packer
authors: Richard A
authors: RA
authors: Robb
mesh_terms: D001281:Atrial Fibrillation / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D008955:Models, Cardiovascular; D010865:Pilot Projects; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome; D014584:User-Computer Interface
references: Circulation. 1994 Mar;89(3):1301-5
references: 8124819
references: J Appl Physiol (1985). 1998 Jul;85(1):5-34
references: 9714612
references: Int J Comput Assist Radiol Surg. 2012 Jan;7(1):13-25
references: 21671097
references: Comput Methods Programs Biomed. 2009 Aug;95(2):95-104
references: 19285747
references: Crit Rev Biomed Eng. 2010;38(1):1-20
references: 21175400
references: Circulation. 2000 Aug 8;102(6):698-705
references: 10931812
references: Europace. 2008 Aug;10(8):931-8
references: 18511437
references: Crit Rev Biomed Eng. 2010;38(1):53-63
references: 21175403
references: IEEE Trans Biomed Eng. 2010 Jun;57(6):1467-75
references: 20172807
references: Heart Rhythm. 2005 Apr;2(4):413-5
references: 15851346
references: Heart Rhythm. 2005 Sep;2(9):1020
references: 16171764
references: Crit Rev Biomed Eng. 2010;38(1):21-30
references: 21175401