title: Multi-voxel pattern analysis of selective representation of visual working memory in ventral temporal and occipital regions.
abstract: While previous results from univariate analysis showed that the activity level of the parahippocampal gyrus (PHG) but not the fusiform gyrus (FG) reflects selective maintenance of the cued picture category, present results from multi-voxel pattern analysis (MVPA) showed that the spatial response patterns of both regions can be used to differentiate the selected picture category in working memory. The ventral temporal and occipital areas including the PHG and FG have been shown to be specialized in perceiving and processing different kinds of visual information, though their role in the representation of visual working memory remains unclear. To test whether the PHG and FG show spatial response patterns that reflect selective maintenance of task-relevant visual working memory in comparison with other posterior association regions, we reanalyzed data from a previous fMRI study of visual working memory with a cue inserted during the delay period of a delayed recognition task. Classification of FG and PHG activation patterns for the selected category (face or scene) during the cue phase was well above chance using classifiers trained with fMRI data from the cue or probe phase. Classification of activity in other temporal and occipital regions for the cued picture category during the cue phase was relatively less consistent even though classification of their activity during the probe recognition was comparable with the FG and PHG. In sum, these findings suggest that the FG and PHG carry information relevant to the cued visual category, and their spatial activation patterns during selective maintenance seem to match those during visual recognition.
authors: Department of Computer Science, State University of New York at Stony Brook, Stony Brook, NY 11794–2500, USA.
authors: Xufeng
authors: X
authors: Han
authors: Alexander C
authors: AC
authors: Berg
authors: Hwamee
authors: H
authors: Oh
authors: Dimitris
authors: D
authors: Samaras
authors: Hoi-Chung
authors: HC
authors: Leung
mesh_terms: D002540:Cerebral Cortex / Q000502:physiology; D003463:Cues; D005145:Face; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008570:Memory, Short-Term / Q000502:physiology*; D009778:Occipital Lobe / Q000502:physiology*; D020534:Parahippocampal Gyrus / Q000502:physiology; D046709:Pattern Recognition, Physiological / Q000502:physiology*; D010775:Photic Stimulation; D015203:Reproducibility of Results; D060388:Support Vector Machine; D013702:Temporal Lobe / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology
references: J Cogn Neurosci. 2000;12 Suppl 2:90-105
references: 11506650
references: J Cogn Neurosci. 2005 Mar;17(3):507-17
references: 15814009
references: J Cogn Neurosci. 2010 Feb;22(2):292-306
references: 19400681
references: Hum Brain Mapp. 2009 May;30(5):1637-51
references: 18661501
references: J Neurosci. 2009 Aug 26;29(34):10638-52
references: 19710316
references: Curr Opin Neurobiol. 2005 Apr;15(2):175-82
references: 15831399
references: Nature. 1998 Apr 9;392(6676):598-601
references: 9560155
references: J Neurosci. 2011 Sep 28;31(39):13771-85
references: 21957240
references: J Neurosci. 2008 Aug 27;28(35):8765-71
references: 18753378
references: J Neurosci. 1993 Apr;13(4):1460-78
references: 8463829
references: Neuroimage. 2010 Jan 15;49(2):1632-40
references: 19815081
references: J Neurosci. 2009 Dec 2;29(48):15258-65
references: 19955378
references: Nat Neurosci. 2005 May;8(5):686-91
references: 15852013
references: J Neurosci. 2011 Jan 26;31(4):1238-45
references: 21273408
references: J Neurosci. 2009 Aug 26;29(34):10573-81
references: 19710310
references: Science. 2005 Dec 23;310(5756):1963-6
references: 16373577
references: Neuroimage. 2011 May 15;56(2):476-96
references: 20488249
references: Nat Neurosci. 2005 May;8(5):679-85
references: 15852014
references: Trends Neurosci. 2000 Jun;23(6):247-51
references: 10838593
references: Curr Opin Neurobiol. 1997 Aug;7(4):554-61
references: 9287197
references: Curr Opin Neurobiol. 1994 Apr;4(2):157-65
references: 8038571
references: J Neurosci. 1997 Jun 1;17(11):4302-11
references: 9151747
references: Neuroimage. 2007 Aug 1;37(1):290-9
references: 17574442
references: Cortex. 2003 Sep-Dec;39(4-5):927-46
references: 14584560
references: Neuropsychologia. 2011 May;49(6):1569-77
references: 21420421
references: Science. 2001 Sep 28;293(5539):2425-30
references: 11577229
references: Neuroimage. 2006 Feb 15;29(4):1117-26
references: 16226895
references: J Cogn Neurosci. 2007 Nov;19(11):1836-44
references: 17958486
references: J Cogn Neurosci. 2003 Aug 15;15(6):771-84
references: 14511531
references: J Neurosci. 2012 Aug 22;32(34):11812-9
references: 22915122
references: Neuroscience. 2006 Apr 28;139(1):23-38
references: 16324795
references: J Neurosci. 2004 Apr 21;24(16):3917-25
references: 15102907
references: Neuroimage. 2005 Jul 1;26(3):733-43
references: 15955482
references: Neuropsychologia. 2011 Feb;49(3):277-98
references: 21095199
references: J Cogn Neurosci. 2012 Jan;24(1):61-79
references: 21955164
references: Nature. 2009 Apr 2;458(7238):632-5
references: 19225460
references: J Cogn Neurosci. 2004 Apr;16(3):363-73
references: 15072672
references: Neuropsychologia. 2012 Mar;50(4):470-8
references: 22108440
references: Nat Neurosci. 1999 Oct;2(10):913-9
references: 10491613