title: Synthesis and biological evaluation of phosphonate analogues of nevirapine.
abstract: A series of nevirapine-based analogues containing the phosphonate functionality were prepared and evaluated in vitro against HIV RT. The effect of the phosphonate was evaluated against the wild type and Y181C HIV replication. An in vivo PK study was performed on a select analogue.
authors: Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA. Jay.Parrish@gilead.com
authors: Jay
authors: J
authors: Parrish
authors: Leah
authors: L
authors: Tong
authors: Michael
authors: M
authors: Wang
authors: Xiaowu
authors: X
authors: Chen
authors: Eric B
authors: EB
authors: Lansdon
authors: Carina
authors: C
authors: Cannizzaro
authors: Xubin
authors: X
authors: Zheng
authors: Manoj C
authors: MC
authors: Desai
authors: Lianhong
authors: L
authors: Xu
mesh_terms: D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D019829:Nevirapine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine