title: Lewy body pathology in a patient with a homozygous parkin deletion.
abstract: BACKGROUND
  We report neuropathologic findings in a patient with homozygous deletions of exons 2 to 4 of parkin.
  
  
  RESULTS
  Although the absence of Lewy bodies has been considered a neuropathologic characteristic of parkin mutation, here we report a pathologic finding with the presence of Lewy bodies.
  
  
  METHODS
  The patient was a 72-year-old woman with onset of the disease at age 61. Her autopsy revealed marked decrease in melanized neurons in the substantia nigra and the locus coeruleus. Lewy bodies were found in the substantia nigra, the locus coeruleus, the dorsal motor nucleus of the vagus, the basal nucleus of Meynert, the amygdaloid nucleus, and the sympathetic nerve bundles in the myocardium.
  
  
  CONCLUSIONS
  Only 3 previous case reports described Lewy body formation in patients carrying parkin mutations. The distribution of Lewy bodies in our patient appeared to be reminiscent of sporadic Parkinson's disease.
authors: Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan. saomiya@med.kitasato-u.ac.jp
authors: Saori
authors: S
authors: Miyakawa
authors: Mieko
authors: M
authors: Ogino
authors: Sayaka
authors: S
authors: Funabe
authors: Akiko
authors: A
authors: Uchino
authors: Yasushi
authors: Y
authors: Shimo
authors: Nobutaka
authors: N
authors: Hattori
authors: Masaaki
authors: M
authors: Ichinoe
authors: Tetuo
authors: T
authors: Mikami
authors: Makoto
authors: M
authors: Saegusa
authors: Kazutoshi
authors: K
authors: Nishiyama
authors: Hideo
authors: H
authors: Mori
authors: Yoshikuni
authors: Y
authors: Mizuno
authors: Shigeo
authors: S
authors: Murayama
authors: Hideki
authors: H
authors: Mochizuki
mesh_terms: D000368:Aged; D005091:Exons / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D006720:Homozygote; D006801:Humans; D016631:Lewy Bodies / Q000235:genetics / Q000473:pathology*; D020961:Lewy Body Disease / Q000235:genetics* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009474:Neurons / Q000473:pathology; D013378:Substantia Nigra / Q000473:pathology; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D051844:alpha-Synuclein; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein