title: Polymorphism of antigen MPT64 in Mycobacterium tuberculosis strains.
abstract: We selected 180 clinical isolates of the Mycobacterium tuberculosis complex (MTBC) from patients in China and performed comparative sequence analysis of the mpt64 gene after amplification. From the results, we found that polymorphisms of the mpt64 gene in the MTBC may be the reason for changes in the antigen produced, which may in turn cause alterations of related functions, thereby allowing immune evasion.
authors: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control, Beijing, China.
authors: Yi
authors: Y
authors: Jiang
authors: Haican
authors: H
authors: Liu
authors: Haiyin
authors: H
authors: Wang
authors: Xiangfeng
authors: X
authors: Dou
authors: Xiuqin
authors: X
authors: Zhao
authors: Yun
authors: Y
authors: Bai
authors: Li
authors: L
authors: Wan
authors: Guilian
authors: G
authors: Li
authors: Wen
authors: W
authors: Zhang
authors: Chen
authors: C
authors: Chen
authors: Kanglin
authors: K
authors: Wan
mesh_terms: D000942:Antigens, Bacterial / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D001483:Base Sequence; D002681:China; D006801:Humans; D057131:Immune Evasion; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification; D021141:Nucleic Acid Amplification Techniques; D020641:Polymorphism, Single Nucleotide; D017434:Protein Structure, Tertiary; D017422:Sequence Analysis, DNA; D014376:Tuberculosis / Q000382:microbiology
chemical_list: D000942:Antigens, Bacterial; C510537:MPT64 protein, Mycobacterium tuberculosis
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