title: Core-shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery.
abstract: Core-shell structured multifunctional nanocarriers (NCs) of ZnO quantum dots-conjugated gold nanoparticles (Au NPs) as core and amphiphilic hyperbranched block copolymer as shell were synthesized for targeted anticancer drug delivery. The amphiphilic hyperbranched block copolymer contained poly(l-lactide) (PLA) inner arm and folate (FA)-conjugated a sulfated polysaccharide from Gynostemma pentaphyllum Makino (GPPS-FA) outer arm. The structure and properties of core-shell structured multifunctional nanocarriers were characterized and determined by UV-visible spectra, FT-IR spectra, X-ray diffraction (XRD), fluorescence spectroscopy and TEM analyses. The release results indicated that camptothecin (CPT) release from NCs at pH 7.4 was much greater than that at pH 5.3. The cytotoxicity studies showed that both the blank NCs and the CPT-loaded NCs provided high anticancer activity against Hela cells. Furthermore, nanocarriers gained specificity to target model cancer cells in this study due to the enhanced cell uptake mediated by FA moiety. The results indicated that the NCs not only had great potential as tumor-targeted drug delivery nanocarrier, but also had an assistant role in the treatment of cancer.
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou 730000, China. chentong2006@163.com
authors: Tong
authors: T
authors: Chen
authors: Tong
authors: T
authors: Zhao
authors: Dongfeng
authors: D
authors: Wei
authors: Yanxia
authors: Y
authors: Wei
authors: Yuanyuan
authors: Y
authors: Li
authors: Haixia
authors: H
authors: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D029774:Gynostemma / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry; D045663:Quantum Dots; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D011134:Polysaccharides; D019344:Lactic Acid; C033616:poly(lactide); D006046:Gold; D005492:Folic Acid; D015034:Zinc Oxide