title: Deciphering the 8q24.21 association for glioma.
abstract: We have previously identified tagSNPs at 8q24.21 influencing glioma risk. We have sought to fine-map the location of the functional basis of this association using data from four genome-wide association studies, comprising a total of 4147 glioma cases and 7435 controls. To improve marker density across the 700 kb region, we imputed genotypes using 1000 Genomes Project data and high-coverage sequencing data generated on 253 individuals. Analysis revealed an imputed low-frequency SNP rs55705857 (P = 2.24 × 10(-38)) which was sufficient to fully capture the 8q24.21 association. Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)). Validation of the non-GBM association was shown in three additional datasets (625 non-GBM cases, 2412 controls; P = 1.41 × 10(-28)). In the pooled analysis, the odds ratio for low-grade glioma associated with rs55705857 was 4.3 (P = 2.31 × 10(-94)). rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26 raising the possibility of direct functionality. These data provide additional insights into the aetiological basis of glioma development.
authors: Division of Genetics and Epidemiology, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
authors: Victor
authors: V
authors: Enciso-Mora
authors: Fay J
authors: FJ
authors: Hosking
authors: Ben
authors: B
authors: Kinnersley
authors: Yufei
authors: Y
authors: Wang
authors: Sanjay
authors: S
authors: Shete
authors: Diana
authors: D
authors: Zelenika
authors: Peter
authors: P
authors: Broderick
authors: Ahmed
authors: A
authors: Idbaih
authors: Jean-Yves
authors: JY
authors: Delattre
authors: Khe
authors: K
authors: Hoang-Xuan
authors: Yannick
authors: Y
authors: Marie
authors: Anna Luisa
authors: AL
authors: Di Stefano
authors: Marianne
authors: M
authors: Labussière
authors: Sara
authors: S
authors: Dobbins
authors: Blandine
authors: B
authors: Boisselier
authors: Pietro
authors: P
authors: Ciccarino
authors: Marta
authors: M
authors: Rossetto
authors: Georgina
authors: G
authors: Armstrong
authors: Yanhong
authors: Y
authors: Liu
authors: Konstantinos
authors: K
authors: Gousias
authors: Johannes
authors: J
authors: Schramm
authors: Ching
authors: C
authors: Lau
authors: Sarah J
authors: SJ
authors: Hepworth
authors: Konstantin
authors: K
authors: Strauch
authors: Martina
authors: M
authors: Müller-Nurasyid
authors: Stefan
authors: S
authors: Schreiber
authors: Andre
authors: A
authors: Franke
authors: Susanne
authors: S
authors: Moebus
authors: Lewin
authors: L
authors: Eisele
authors: Asta
authors: A
authors: Forsti
authors: Kari
authors: K
authors: Hemminki
authors: Ian P
authors: IP
authors: Tomlinson
authors: Anthony
authors: A
authors: Swerdlow
authors: Mark
authors: M
authors: Lathrop
authors: Matthias
authors: M
authors: Simon
authors: Melissa
authors: M
authors: Bondy
authors: Marc
authors: M
authors: Sanson
authors: Richard S
authors: RS
authors: Houlston
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D056726:Genetic Association Studies; D005838:Genotype; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D060787:Neoplasm Grading; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
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