title: Major depression and PTSD in pregnant smokers enrolled in nicotine gum treatment trial.
abstract: OBJECTIVE
  Pregnant women face considerable barriers to smoking cessation. The purpose of this study was to determine the prevalence of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) and response to smoking cessation treatment in pregnant smokers participating in a randomized, placebo-controlled trial of nicotine gum.
  
  
  METHODS
  Participants were 194 low-income, ethnically diverse pregnant smokers.
  
  
  RESULTS
  Utilizing a structured interview, 45% and 18% of the subjects met criteria for a lifetime diagnosis of MDD and PTSD, respectively. There was no difference in response to treatment, based on the presence of either of these psychiatric disorders.
  
  
  CONCLUSIONS
  Cumulatively, these findings provide evidence of the high degree of unmet mental health needs in pregnant smokers.
  
  
  CONCLUSIONS
  Pregnant women with a history of MDD and PTSD appear to be as likely to benefit from smoking cessation treatment as those without such a history.
authors: Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA. edornel@harthosp.org
authors: Ellen
authors: E
authors: Dornelas
authors: Cheryl
authors: C
authors: Oncken
authors: John
authors: J
authors: Greene
authors: Heather Z
authors: HZ
authors: Sankey
authors: Henry R
authors: HR
authors: Kranzler
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000150:complications*; D005260:Female; D006630:Hispanic or Latino / Q000523:psychology; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D015995:Prevalence; D012907:Smoking / Q000188:drug therapy*; D013313:Stress Disorders, Post-Traumatic / Q000150:complications*; D061485:Tobacco Use Cessation Devices
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