title: Salivary cortisol determination in patients from the Basque Country with recurrent aphthous stomatitis. A pilot study.
abstract: OBJECTIVE
  Stress and anxiety are controversial factors involved in the complex pathogenesis of Recurrent Aphthous Stomatitis (RAS). The determination of salivary cortisol is a useful, simple and safe test to detect states of high stress or anxiety. The aim of this study is to check for changes in salivary cortisol levels in patients with RAS during periods of active disease.
  
  
  METHODS
  A measurement of cortisol employing Enzyme-Linked Immuno Sorbent Assay (ELISA) was carried out in samples of unstimulated saliva from 20 patients with active lesions of RAS and 10 healthy individuals used as controls.
  
  
  RESULTS
  Increased levels of salivary cortisol were detected in 3 cases, all of them within the group of patients with RAS. In none of the control group patients the level of salivary cortisol was increased. The mean level of salivary cortisol was 0.64 mg / dl (range 0.2 to 1.62) for patients with RAS and 0.57 mg / dl (range 0.25 to 1.09) for controls.
  
  
  CONCLUSIONS
  Salivary cortisol levels are not statistically higher in patients with active lesions of RAS.
authors: Oral Medicine Unit, Faculty of Medicine and Dentistry, UFI 11/25, University of Basque Country / EHU. aeguiadelvalle@yahoo.es
authors: Asier
authors: A
authors: Eguia-del Valle
authors: Rafael
authors: R
authors: Martínez-Conde-Llamosas
authors: José
authors: J
authors: López-Vicente
authors: Agurne
authors: A
authors: Uribarri-Etxebarria
authors: José-Manuel
authors: JM
authors: Aguirre-Urizar
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012008:Recurrence; D012463:Saliva / Q000737:chemistry*; D013281:Stomatitis, Aphthous / Q000378:metabolism*; D055815:Young Adult
chemical_list: D006854:Hydrocortisone
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