title: Drug discovery algorithm for cutaneous leishmaniasis.
abstract: Cutaneous leishmaniasis is clinically widespread but lacks treatments that are effective and well tolerated. Because all present drugs have been grandfathered into clinical use, there are no examples of a pre-clinical product evaluation scheme that lead to new candidates for formal development. To provide oral agents for development targeting cutaneous leishmaniasis, we have implemented a discovery scheme that incorporates in vitro and in vivo testing of efficacy, toxicity, and pharmacokinetics/metabolism. Particular emphasis is placed on in vivo testing, progression from higher-throughput models to those with most clinical relevance, and efficient use of resources.
authors: Division Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. max.grogl1@us.army.mil
authors: Max
authors: M
authors: Grogl
authors: Mark
authors: M
authors: Hickman
authors: William
authors: W
authors: Ellis
authors: Thomas
authors: T
authors: Hudson
authors: John S
authors: JS
authors: Lazo
authors: Elizabeth R
authors: ER
authors: Sharlow
authors: Jacob
authors: J
authors: Johnson
authors: Jonathan
authors: J
authors: Berman
authors: Richard J
authors: RJ
authors: Sciotti
mesh_terms: D000465:Algorithms; D000818:Animals; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*
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