title: Natural Killer T cell obsession with self-antigens.
abstract: Natural Killer T (NKT) cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical Major Histocompatibility Complex molecule CD1d. Two categories of NKT cells, type I and type II, have been described based on T-cell receptor expression and antigenic specificity. In both cases, increasing evidence suggest that recognition of self-antigens by these cells plays an important role not only in their development but also in their regulation of a broad range of immune responses. Here we review recent advances in our understanding of how and when NKT cell autoreactivity manifests itself, how the NKT T cell receptor engages self-antigens and the nature of these self-antigens.
authors: Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA. gapinl@njhealth.org
authors: Laurent
authors: L
authors: Gapin
authors: Dale I
authors: DI
authors: Godfrey
authors: Jamie
authors: J
authors: Rossjohn
mesh_terms: D001324:Autoantigens / Q000276:immunology*; D006801:Humans; D055611:Natural Killer T-Cells / Q000276:immunology*
chemical_list: D001324:Autoantigens
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