title: Ozonolysis efficiency and safety evaluation of aflatoxin B1 in peanuts.
abstract: Ozonolysis efficiency of aflatoxin-contaminated peanuts (ACPs) was investigated, and the safety of ACPs untreated/treated by ozone was evaluated after 28-day intragastrically administration in male and female Wistar rats. 89.40% of aflatoxin B1 (AFB1) in peanuts was decomposed by ozone with a concentration of 50mg/L, flow rate of 5L/min for 60h. After 60h, the ozonolysis efficiency of AFB1 was not further improved. In the subchronic toxicity experiment, all rats did not have unusual changes in behavior, and no signs of intoxication were observed except for several dead rats due to inappropriate gavage or anesthesia. The results of subchronic toxicity indicated that rats fed on ACPs alone had significantly decreased in body weight gain and feed conversion efficiency. Most serum biochemical indexes of rats had apparently changed compared with those in the negative control, and gender difference significantly affected most indexes of subchronic toxicity except for the ratios of organ to body weight and histopathological observation. Rats fed on ACPs treated by ozone showed significant beneficial health effects. All the results suggested that the deleterious effects of AFB1 could be highly reduced by ozone, and ozone itself did not show any toxic effects on animals in this processing.
authors: College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, PR China. dej110@163.com
authors: Enjie
authors: E
authors: Diao
authors: Hanxue
authors: H
authors: Hou
authors: Bin
authors: B
authors: Chen
authors: Changpo
authors: C
authors: Shan
authors: Haizhou
authors: H
authors: Dong
mesh_terms: D016604:Aflatoxin B1 / Q000737:chemistry* / Q000633:toxicity*; D000818:Animals; D010367:Arachis / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010126:Ozone / Q000737:chemistry*; D051381:Rats; D059550:Toxicity Tests, Subchronic
chemical_list: D010126:Ozone; D016604:Aflatoxin B1