title: Preparation and characterization of glycol chitin as a new thermogelling polymer for biomedical applications.
abstract: In this study, a new thermo-sensitive polymer, glycol chitin, was synthesized by controlled N-acetylation of glycol chitosan and evaluated as a thermogelling system. The physico-chemical properties of glycol chitins with different degrees of acetylation (DA) were investigated in terms of degradation, cytotoxicity, rheological properties, and in vitro and in vivo gel formation. Aqueous solutions of glycol chitins were flowable freely at room temperature but quickly became a durable gel at body temperature. Thermo-reversible sol-gel transition properties were observed with fast gelation kinetics. Glycol chitins with higher DA showed faster degradation in the presence of lysozyme. They exhibited no significant biological toxicity against human cell lines. An anti-cancer drug, doxorubicin, could be incorporated into the hydrogel by a simple mixing process and released in a sustained pattern over 13 days. Our findings suggest that glycol chitins could be useful as a new thermogelling biomaterial for drug delivery and injectable tissue engineering.
authors: Department of Polymer Science and Engineering, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon 305-764, Republic of Korea.
authors: Zhengzheng
authors: Z
authors: Li
authors: Sungpil
authors: S
authors: Cho
authors: Ick Chan
authors: IC
authors: Kwon
authors: Margit M
authors: MM
authors: Janát-Amsbury
authors: Kang Moo
authors: KM
authors: Huh
mesh_terms: D000107:Acetylation; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D002686:Chitin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D005782:Gels; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D005782:Gels; D002686:Chitin; C031610:glycolchitin