title: Comparison of original and generic clopidogrel 600 mg loading dose in the patients who planned undergoing coronary angiography.
abstract: OBJECTIVE
  To compare the efficacy and safety of original (Plavix) and generic (Apolets) clopidogrel 600 mg loading in patients planning to undergo coronary angiography.
  
  
  METHODS
  This is an experimental design, parallel, randomized-controlled study. Coronary artery disease patients planned for cardiac catheterization were recruited Patients were randomized to receive either original or generic clopidogrel 600 mg loading dose. Platelet aggregation induced by 5 micromol/L and 20 micromol/L adenosine diphosphate (ADP) was measured by light transmission aggregometry (LTA) at baseline and 6 hours after clopidogrel 600 mg administration.
  
  
  RESULTS
  Forty-nine patients were enrolled, 24 patients received original clopidogrel, and 25 patients received generic clopidogrel. After six hours of loading, there was significantly reduction in platelet aggregation induced by adenosine 5 micromol/L from 41.08 +/- 3.04% to 19.50 +/- 1.68% (p < 0.001) in original group compared to 36.76 +/- 2.66% to 21.32 +/- 2.60% (p < 0.001) in generic group. When induced by 20 micromol/L, the platelet aggregation was reduced from 58.50 +/- 2.09% to 32.25 +/- 2.30% (p < 0.001) in original group and from 61.12 +/- 2.54% to 30.04 +/- 3.14% (p < 0.001) in generic group. There was no significant difference between original and generic clopidogrel in reducing platelet aggregation induced by both adenosine 5 and 20 micromol/L. Groin hematoma was found in one case (4.2%) in the original clopidogrel group.
  
  
  CONCLUSIONS
  Generic clopidogrel (Apolets) 600 mg loading dose is as effective as original clopidogrel (Plavix) in term of platelet aggregation inhibition.
authors: Cardiac Center and Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. s_srimahachota@yahoo.co.th
authors: Suphot
authors: S
authors: Srimahachota
authors: Ponlapat
authors: P
authors: Rojnuckarin
authors: Wasan
authors: W
authors: Udayachalerm
authors: Wacin
authors: W
authors: Buddhari
authors: Jarkarpun
authors: J
authors: Chaipromprasit
authors: Vorarit
authors: V
authors: Lertsuwunseri
authors: Benjaporn
authors: B
authors: Akkawat
authors: Somboon
authors: S
authors: Jirapattrathamrong
mesh_terms: D000244:Adenosine Diphosphate / Q000008:administration & dosage; D000077144:Clopidogrel; D017023:Coronary Angiography; D016568:Drugs, Generic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D010979:Platelet Function Tests / Q000295:instrumentation; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D016568:Drugs, Generic; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D000077144:Clopidogrel; D013988:Ticlopidine