title: Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives.
abstract: A series of s-triazolobenzothiazolylthioacetyl/propionyl amino acid derivatives were synthesized with the aim of evaluating their antifungal activity. Their chemical structures were confirmed by (1)H, (13)C NMR, IR, mass spectrometry and elemental analyses. The synthesized derivatives were screened for their antifungal activity against Aspergillus flavus and Candida albicans. Five compounds (3, 5, 7c, 8 and 17) were found to possess high activity comparable to fluconazole at 100 μg/mL against C. albicans.
authors: Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41511, Egypt. ahmedaelmagd@gmail.com
authors: A
authors: A
authors: Aboelmagd
authors: Ibrahim A I
authors: IA
authors: Ali
authors: Ezzeldin M S
authors: EM
authors: Salem
authors: M
authors: M
authors: Abdel-Razik
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects*; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000935:Antifungal Agents; D052160:Benzothiazoles; D014230:Triazoles