title: NAT2 sequence polymorphisms and acetylation profiles in Indians.
abstract: BACKGROUND
  NAT2, a broad-spectrum drug-metabolizing gene, is of high pharmacogenetic interest. Based on seven different mutations in the NAT2 gene, an individual can either be categorized as a slow or fast acetylator.
  
  
  METHODS
  In order to characterize acetylation profiles of Indians, where data are poorly available, we sequenced the 873 bp NAT2 coding region in 250 Indians, covering the whole of India including three tribes.
  
  
  RESULTS
  Altogether, 35 NAT2 alleles forming two acetylator phenotypes (distributed almost in equal proportion in India) were found; while the alleles determining slow acetylators were highly differentiated, the fast acetylator alleles were less in number but highly frequent.
  
  
  CONCLUSIONS
  Interestingly, distribution of two different acetylation phenotypes correlated well with historical dietary pattern in India. The neighbor-joining phylogenetic tree based on NAT2 gene polymorphisms in worldwide humans revealed genetic affinities among populations with similar acetylation phenotypes, which also placed Indians and Africans together in a single cluster.
authors: Evolutionary Genomics & Bioinformatics Laboratory, Division of Genomics & Bioinformatics, National Institute of Malaria Research, New Delhi, India.
authors: Naazneen
authors: N
authors: Khan
authors: Veena
authors: V
authors: Pande
authors: Aparup
authors: A
authors: Das
mesh_terms: D000107:Acetylation; D000483:Alleles; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D044383:Black People; D019143:Evolution, Molecular; D005247:Feeding Behavior; D006801:Humans; D007194:India; D020641:Polymorphism, Single Nucleotide
chemical_list: D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human