title: Transcranial magnetic stimulation-electroencephalography responses in recovered and symptomatic mild traumatic brain injury.
abstract: Mild traumatic brain injury (mTBI) may cause diffuse damage to the brain, especially to the frontal areas, that may lead to persistent symptoms. We studied participants with past mTBI by means of navigated transcranial magnetic stimulation (nTMS) combined with electroencephalography (EEG). Eleven symptomatic and 8 recovered participants with a history of single mTBI and 9 healthy controls participated. Average time from injury to testing was 5 years. The participants did not have abnormalities or signs of injury on brain magnetic resonance imaging, and they did not use any centrally acting medication. Left primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) were stimulated with nTMS and evoked potentials measured from the corresponding areas of both hemispheres. Delayed ipsilateral P30 and contralateral N45 peak latencies to left DLPFC nTMS were found in the symptomatic group, along with higher DLPFC N100 amplitudes compared with the control or recovered group. The recovered group had shorter P200 latencies in left DLPFC nTMS compared with the other groups. Both mTBI groups had higher motor thresholds compared with the control group. In left M1 nTMS, the mTBI groups showed less P30 amplitude increase, and the symptomatic group showed longer P60 interhemispheric latency difference with higher stimulation intensities. The results suggest altered brain reactivity and connectivity in mTBI. Some of the observed differences may be related to compensatory mechanisms of recovery. nTMS-EEG is a potentially useful tool for studying the effects of mTBI.
authors: Department of Psychology, Centre for Cognitive Neuroscience, University of Turku, Turku, Finland. jptall@utu.fi
authors: Jussi
authors: J
authors: Tallus
authors: Pantelis
authors: P
authors: Lioumis
authors: Heikki
authors: H
authors: Hämäläinen
authors: Seppo
authors: S
authors: Kähkönen
authors: Olli
authors: O
authors: Tenovuo
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000503:physiopathology*; D016002:Discriminant Analysis; D004569:Electroencephalography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D015600:Glasgow Coma Scale; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology; D020127:Recovery of Function; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult
references: J Neurophysiol. 2005 Jul;94(1):622-39
references: 15788519
references: J Neurotrauma. 2012 Jan 20;29(2):281-94
references: 21933013
references: Neuroimage. 2005 Feb 15;24(4):955-60
references: 15670672
references: Brain Res Rev. 2006 Aug 30;52(1):183-92
references: 16545462
references: JAMA. 2003 Nov 19;290(19):2549-55
references: 14625331
references: Brain Cogn. 2004 Dec;56(3):304-12
references: 15522768
references: J Neurotrauma. 2010 Jan;27(1):65-76
references: 19761385
references: J Neurol Neurosurg Psychiatry. 2003 Mar;74(3):326-32
references: 12588917
references: Neurology. 2010 Feb 23;74(8):643-50
references: 20089939
references: Neuroimage. 2011 Jan 1;54(1):90-102
references: 20682352
references: Med Biol Eng Comput. 1999 May;37(3):322-6
references: 10505382
references: J Neurophysiol. 1967 Jul;30(4):844-58
references: 6035693
references: Neurology. 2008 Mar 18;70(12):948-55
references: 18347317
references: J Neurotrauma. 2005 Mar;22(3):333-44
references: 15785229
references: J Neurosci Methods. 2008 Jul 30;172(2):270-6
references: 18533272
references: Eur J Neurosci. 2009 Sep;30(5):913-23
references: 19712104
references: J Neurotrauma. 2011 Mar;28(3):329-41
references: 21309680
references: Epilepsy Res. 2011 Sep;96(1-2):123-31
references: 21726980
references: Electroencephalogr Clin Neurophysiol. 1994 Aug;91(2):79-92
references: 7519144
references: Hum Brain Mapp. 2004 Mar;21(3):154-64
references: 14755835
references: J Neurotrauma. 2009 Dec;26(12):2365-82
references: 19715396
references: Cortex. 2009 Oct;45(9):1035-42
references: 19371866
references: Acta Neurol Scand. 2012 Sep;126(3):178-82
references: 22103909
references: AJNR Am J Neuroradiol. 2007 May;28(5):907-13
references: 17494667
references: Hum Brain Mapp. 2009 Apr;30(4):1387-96
references: 18537115
references: Brain Inj. 2009 Jul;23(7):675-85
references: 19557571
references: Acta Neurochir (Wien). 1998;140(5):467-72
references: 9728247
references: Neurophysiol Clin. 2010 Mar;40(1):7-17
references: 20230931
references: Neuropsychopharmacology. 2003 Apr;28(4):747-54
references: 12655321
references: Brain. 2012 Jul;135(Pt 7):2215-30
references: 22492560
references: Brain. 1997 May;120 ( Pt 5):839-53
references: 9183254
references: Exp Brain Res. 2009 Apr;194(4):517-26
references: 19241068
references: Radiology. 2009 Sep;252(3):816-24
references: 19567646
references: J Clin Neurophysiol. 2008 Dec;25(6):367-72
references: 18997630
references: Exp Brain Res. 2006 Nov;175(2):231-45
references: 16783559
references: Clin Neurophysiol. 2006 Aug;117(8):1699-707
references: 16797232
references: J Neurol Neurosurg Psychiatry. 2001 May;70(5):580-7
references: 11309450
references: J Neurotrauma. 2009 Dec;26(12):2185-93
references: 19604100
references: Eur J Neurosci. 2003 Sep;18(5):1206-12
references: 12956719
references: Neurosurgery. 2007 Aug;61(2):329-36; discussion 336-7
references: 17762745
references: Neuroimage. 2011 Apr 15;55(4):1716-27
references: 21255654
references: Brain. 2009 Mar;132(Pt 3):695-708
references: 19176544
references: Radiology. 2013 Apr;267(1):231-9
references: 23297328
references: Clin Neurophysiol. 2002 Feb;113(2):175-84
references: 11856623
references: AJNR Am J Neuroradiol. 2004 May;25(5):730-7
references: 15140711
references: Exp Brain Res. 2006 Nov;175(2):246-55
references: 16832683
references: Neuroimage. 2011 Jan;54 Suppl 1:S21-9
references: 20851190
references: Neurosci Lett. 2012 Feb 10;509(1):5-8
references: 22108503
references: Brain. 2000 Jul;123 ( Pt 7):1403-9
references: 10869052
references: Lancet. 1985 May 11;1(8437):1106-7
references: 2860322
references: J Neurophysiol. 2001 Oct;86(4):1983-90
references: 11600655