title: The rational use of animals in drug development: contribution of the innovative medicines initiative.
abstract: Animal models are still widely used to assess the efficacy or safety of new pharmaceutical products. Since their limitations in predicting actions of drugs in humans are becoming more and more apparent, there is an urgent need to revisit the use of animals in pharmaceutical research. Herein, we review how the Innovative Medicines Initiative (IMI), the largest public-private partnership in the life sciences, is reducing, refining and replacing the use of animals in the context of its global mission, namely, to boost research and the development of new medicines across the European Union.
authors: Innovative Medicines Initiative, Brussels, Belgium.
authors: Gunn
authors: G
authors: Magda
authors: Elisabetta
authors: E
authors: Vaudano
authors: Michel
authors: M
authors: Goldman
mesh_terms: D032761:Animal Experimentation; D023401:Animal Use Alternatives; D000818:Animals; D004353:Drug Evaluation, Preclinical; D006801:Humans; D055818:Public-Private Sector Partnerships; D035703:Therapies, Investigational