title: Inclusion of hemoglobin level in prognostic score provides better prognostic stratification in patients with acute promyelocytic leukemia (APL).
abstract: The clinical outcomes of acute promyelocytic leukemia (APL) have improved greatly, but treatment failure still occurs. Identification of patients with poor prognosis is fundamental, and we propose a new clinical prognostic system (CBC-score) consisting of WBC, platelet count, and hemoglobin level. Between 1995 and 2009, 156 patients with APL from seven institutes in Korea were retrospectively reviewed. In the new CBC-score system, each of the following (WBC ≥ 10 × 109/L, platelet <40 × 109/L, hemoglobin <8.0 g/dL) was considered as a risk factor; the sum of each was designated as the CBC-score. With a median follow-up of 8.4 years, the complete remission (CR) rate was 81.4 % (127/156), while 24 (15.4 %) were considered as treatment failures due to early death (ED). The 5-year overall survival (OS), leukemia-free survival, and cumulative incidence of relapse were 73.8, 82.8, and 13.5 %, respectively. Compared to the individual CBC parameters, combined prognostic systems such as PETHEMA or CBC-score provided better prognostic stratification. Compared to PETHEMA stratification, the proposed prognostic CBC-score system showed better stratification of APL patients in terms of CR rates (p = 0.004), OS (p = 0.004), and ED (p = 0.008). This retrospective study suggests that the proposed CBC-score may provide better prognostic stratification of APL patients.
authors: Division of Hematology-Oncology, Department of Medicine, Samsung Meidical Center, Sungkyunkwan University School of Medicine, 50, Irwon-dong, Gangnam-gu, Seoul, 135-710, Korea.
authors: Silvia
authors: S
authors: Park
authors: Su Jin
authors: SJ
authors: Lee
authors: Kihyun
authors: K
authors: Kim
authors: Jun Ho
authors: JH
authors: Jang
authors: Dong Hwan
authors: DH
authors: Kim
authors: Kyu Hyung
authors: KH
authors: Lee
authors: Je Hwan
authors: JH
authors: Lee
authors: Jung Hee
authors: JH
authors: Lee
authors: Dae Young
authors: DY
authors: Kim
authors: Dae-Young
authors: DY
authors: Jang
authors: Hawk
authors: H
authors: Kim
authors: Jae Hoo
authors: JH
authors: Park
authors: Hun Mo
authors: HM
authors: Ryoo
authors: Sung Hwa
authors: SH
authors: Bae
authors: Min Kyung
authors: MK
authors: Kim
authors: Myung Soo
authors: MS
authors: Hyun
authors: Young Don
authors: YD
authors: Joo
authors: Won Sik
authors: WS
authors: Lee
authors: Sang Min
authors: SM
authors: Lee
authors: Chul Won
authors: CW
authors: Jung
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood* / Q000401:mortality* / Q000628:therapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D006454:Hemoglobins
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