title: Risk factors for seropositivity to Kaposi sarcoma-associated herpesvirus among children in Uganda.
abstract: BACKGROUND
  Determinants of Kaposi sarcoma-associated herpesvirus (KSHV) seropositivity among children living in sub-Saharan African populations where infection is endemic are not well understood. Local environmental factors, including other infectious agents, may be key.
  
  
  METHODS
  Within the context of a well-characterized birth cohort, we examined associations between various factors and antibodies against KSHV, measured in stored plasma samples from 1823 mother-child pairs in Entebbe, Uganda.
  
  
  RESULTS
  Seroprevalence increased with increasing age of the child (P = 0.0003) and was higher among those with KSHV seropositive mothers than in those without (12% vs 9%; odds ratio: 1.4, 95% confidence interval: 1.1 to 2.0). It was also higher among children with HIV infection (29% vs 10%; odds ratio: 3.1, 95% confidence interval: 1.2 to 8.3) or malaria parasitemia (30% vs 10%; odds ratio: 4.1, 95% confidence interval: 2.4 to 7.0) than in children without. These associations were not explained by socioeconomic status.
  
  
  CONCLUSIONS
  The finding that KSHV serostatus is associated with malaria parasitemia in children is novel. In a country endemic for KSHV, malaria may be a cofactor for KSHV infection or reactivation among children.
authors: Medical Research Council, Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda. katie.wakeham@mrcuganda.org
authors: Katie
authors: K
authors: Wakeham
authors: Emily L
authors: EL
authors: Webb
authors: Ismail
authors: I
authors: Sebina
authors: Angela
authors: A
authors: Nalwoga
authors: Lawrence
authors: L
authors: Muhangi
authors: Wendell
authors: W
authors: Miley
authors: W Thomas
authors: WT
authors: Johnston
authors: Juliet
authors: J
authors: Ndibazza
authors: Denise
authors: D
authors: Whitby
authors: Robert
authors: R
authors: Newton
authors: Alison M
authors: AM
authors: Elliott
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D002675:Child, Preschool; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D007223:Infant; D008288:Malaria / Q000150:complications / Q000453:epidemiology; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D016036:Seroepidemiologic Studies; D014454:Uganda / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral
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