title: BDNF-TrkB signaling and neuroprotection in schizophrenia.
abstract: Neurotrophins such as brain-derived neurotropic factor (BDNF), play critical role in neuronal survival, synaptic plasticity and cognitive functions. BDNF is known to mediate its action through various intracellular signaling pathways triggered by activation of tyrosine kinase receptor B (TrkB). Evidence from clinical as well pre-clinical studies indicate alterations in BDNF signaling in schizophrenia. Moreover, several antipsychotic drugs have time-dependent effects on BDNF levels in both schizophrenia subjects and animal models of schizophrenia. Given the emerging interest in neuroplasticity in schizophrenia understanding the neuroprotective and cell survival roles of BDNF signaling will enhance our knowledge of its diverse effects, which may lead to more effective treatments for schizophrenia. This article will present an overview of recent findings on the role of BDNF signaling in the pathophysiology and treatment of schizophrenia, with a special focus on its neuroprotective effects.
authors: Department of Psychiatry and Health Behavior, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA.
authors: Chirayu D
authors: CD
authors: Pandya
authors: Ammar
authors: A
authors: Kutiyanawalla
authors: Anilkumar
authors: A
authors: Pillai
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D019208:Brain-Derived Neurotrophic Factor / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D019175:DNA Methylation / Q000502:physiology; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D051381:Rats; D020813:Receptor, trkB / Q000235:genetics / Q000378:metabolism*; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D020813:Receptor, trkB
references: Biol Psychiatry. 2000 Oct 1;48(7):641-50
references: 11032975
references: Neurobiol Dis. 2010 Sep;39(3):327-33
references: 20451611
references: Novartis Found Symp. 2008;289:119-29; discussion 129-35, 193-5
references: 18497099
references: World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):256-61
references: 20218790
references: Am J Psychiatry. 2004 Jan;161(1):109-15
references: 14702258
references: World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):251-5
references: 20218789
references: Nature. 1989 Sep 21;341(6239):197-205
references: 2550825
references: Science. 1990 Mar 23;247(4949 Pt 1):1446-51
references: 2321006
references: Neurosci Lett. 2011 Mar 24;491(3):207-10
references: 21256922
references: Neurosci Lett. 2008 Jul 11;439(2):157-9
references: 18514407
references: J Neurosci Res. 2003 Jan 1;71(1):127-31
references: 12478621
references: Int Clin Psychopharmacol. 2010 Jul;25(4):241-5
references: 20568658
references: Neuron. 2006 Oct 5;52(1):139-53
references: 17015232
references: Nat Genet. 2004 Feb;36(2):131-7
references: 14745448
references: Schizophr Res. 2010 Jun;119(1-3):47-51
references: 20096541
references: J Cell Physiol. 2007 Nov;213(2):384-90
references: 17708532
references: J Psychiatr Res. 2007 Jan-Feb;41(1-2):31-5
references: 16546213
references: Mol Psychiatry. 2002;7(6):579-93
references: 12140781
references: Biol Psychiatry. 2005 Sep 15;58(6):446-50
references: 16026766
references: Am J Hum Genet. 2008 Mar;82(3):696-711
references: 18319075
references: Biol Psychiatry. 2008 Mar 1;63(5):449-57
references: 17825267
references: J Neurosci. 2005 Jan 12;25(2):372-83
references: 15647480
references: Prog Neurobiol. 2001 Jan;63(1):71-124
references: 11040419
references: Histol Histopathol. 2010 Feb;25(2):237-58
references: 20017110
references: Neurosignals. 2008;16(2-3):183-93
references: 18253057
references: Neurosci Lett. 2004 Feb 12;356(2):135-9
references: 14746882
references: Schizophr Res. 2008 Apr;101(1-3):58-66
references: 18289832
references: Curr Opin Drug Discov Devel. 2006 Sep;9(5):580-6
references: 17002218
references: Neuropsychopharmacology. 2012 Jan;37(2):531-42
references: 22048458
references: Nat Med. 2006 Jul;12(7):824-8
references: 16767099
references: Neurosci Lett. 2006 Jul 10;402(1-2):25-9
references: 16713676
references: Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):383-6
references: 16583435
references: Neuropharmacology. 2010 Feb;58(2):330-6
references: 19887077
references: Mol Psychiatry. 2003 Jun;8(6):592-610
references: 12851636
references: Schizophr Res. 2006 Sep;86(1-3):321-2
references: 16829047
references: Mol Psychiatry. 2011 Sep;16(9):960-72
references: 20733577
references: Int J Neuropsychopharmacol. 2010 May;13(4):535-9
references: 19941699
references: Cell Mol Life Sci. 2006 Jul;63(13):1523-37
references: 16699811
references: Mol Cell Neurosci. 1997;9(5-6):397-408
references: 9361277
references: Mol Psychiatry. 2005 Jul;10(7):637-50
references: 15940304
references: Biochim Biophys Acta. 2009 Sep;1790(9):869-77
references: 19559755
references: Arq Bras Cardiol. 2002 Aug;79(2):139-42
references: 12219187
references: Schizophr Res. 2007 Aug;94(1-3):1-11
references: 17524622
references: Mol Psychiatry. 2002;7(5):447-8
references: 12082559
references: J Biol Chem. 1999 Aug 6;274(32):22569-80
references: 10428835
references: Nat Rev Neurosci. 2005 Jun;6(6):463-75
references: 15891777
references: Stroke. 2000 Sep;31(9):2212-7
references: 10978054
references: Mol Psychiatry. 2005 Feb;10(2):208-12
references: 15630410
references: Neuron. 2000 Nov;28(2):325-34
references: 11144342
references: Am J Hum Genet. 2002 Sep;71(3):651-5
references: 12161822
references: Biol Psychiatry. 2004 Nov 1;56(9):698-700
references: 15522255
references: Mol Psychiatry. 2000 May;5(3):293-300
references: 10889532
references: J Psychiatr Res. 2012 Mar;46(3):279-84
references: 22209534
references: J Clin Psychopharmacol. 2011 Jun;31(3):334-6
references: 21508862
references: Curr Opin Neurol. 1996 Apr;9(2):122-5
references: 8782980
references: Am J Med Genet B Neuropsychiatr Genet. 2006 Mar 5;141B(2):135-8
references: 16389585
references: J Neurosci Res. 2003 Jun 1;72(5):622-8
references: 12749027
references: Cell. 2000 Oct 13;103(2):211-25
references: 11057895
references: Mol Psychiatry. 2009 Jul;14(7):681-95
references: 19153574
references: Curr Opin Neurobiol. 2000 Feb;10(1):138-45
references: 10679428
references: Prog Neuropsychopharmacol Biol Psychiatry. 2003 Aug;27(5):801-7
references: 12921913
references: Brain Res. 2011 Oct 12;1417:146-50
references: 21917241
references: Schizophr Bull. 2013 Jan;39(1):130-40
references: 21795612
references: Science. 2003 Oct 31;302(5646):890-3
references: 14593184
references: Neuron. 1990 Oct;5(4):501-9
references: 1688327
references: Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jul;28(4):709-13
references: 15276697
references: Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1508-12
references: 19720106
references: J Psychiatr Res. 2009 Jan;43(3):274-81
references: 18656896
references: J Neurochem. 2008 Nov;107(4):941-51
references: 18786174
references: Eur Neuropsychopharmacol. 2005 May;15(3):311-7
references: 15820421
references: Int Clin Psychopharmacol. 2007 Jan;22(1):21-7
references: 17159456
references: J Pharmacol Exp Ther. 2007 Mar;320(3):961-8
references: 16966470
references: Neurosci Lett. 2007 Jun 8;420(1):45-8
references: 17442489
references: Science. 2006 Oct 6;314(5796):140-3
references: 17023662
references: Schizophr Res. 2001 Oct 1;52(1-2):79-86
references: 11595394
references: J Neurochem. 2005 Aug;94(3):713-22
references: 16000165
references: J Neurosci. 2004 May 5;24(18):4401-11
references: 15128854
references: J Neurosci. 2008 Oct 15;28(42):10576-86
references: 18923034
references: J Affect Disord. 2010 Jul;124(1-2):164-9
references: 19913919
references: Biol Psychiatry. 2009 Sep 15;66(6):549-53
references: 19368899
references: Eur Neuropsychopharmacol. 2005 May;15(3):319-29
references: 15820422
references: J Affect Disord. 2011 Oct;133(3):646-54
references: 21612826
references: J Neurosci Res. 2000 Jun 15;60(6):783-94
references: 10861791
references: Psychopharmacol Bull. 2003 Spring;37(2):79-101
references: 14566217
references: Eur J Neurosci. 2001 Jul;14(1):135-44
references: 11488957
references: Neuropsychopharmacology. 2008 Jul;33(8):1942-51
references: 17805306
references: Neuropsychobiology. 2010;61(1):19-26
references: 19923862
references: Neurobiol Dis. 2004 Jul;16(2):440-53
references: 15193300
references: Cell Death Differ. 2005 Oct;12(10):1329-43
references: 15905876
references: J Psychiatr Res. 2012 Jan;46(1):1-11
references: 22030467
references: Mol Psychiatry. 2002;7(2):136-7
references: 11840305
references: Schizophr Res. 2006 May;84(1):1-14
references: 16581231
references: Neuropsychopharmacology. 2008 Aug;33(9):2200-5
references: 17987059
references: Neurosci Lett. 2005 Jul 1-8;382(1-2):27-32
references: 15911116
references: J Psychiatry Neurosci. 2011 May;36(3):195-203
references: 21223646
references: Annu Rev Neurosci. 2001;24:677-736
references: 11520916
references: Development. 1995 Aug;121(8):2461-70
references: 7671810
references: Trends Neurosci. 1994 Nov;17(11):486-90
references: 7531891
references: Nat Rev Neurosci. 2005 Apr;6(4):312-24
references: 15803162
references: Brain Res Rev. 2007 Dec;56(2):427-42
references: 17980435
references: Annu Rev Neurosci. 1996;19:289-317
references: 8833445
references: J Neurosci. 2012 Mar 21;32(12):4092-101
references: 22442074
references: PLoS One. 2011;6(10):e26153
references: 22039440
references: Neurosci Lett. 2002 Mar 15;321(1-2):65-8
references: 11872258
references: Neurobiol Learn Mem. 2007 Nov;88(4):409-15
references: 17765576
references: Schizophr Res. 2007 Mar;91(1-3):1-5
references: 17306505
references: Cell. 2003 Jan 24;112(2):257-69
references: 12553913
references: Genes Dev. 2002 Jan 1;16(1):6-21
references: 11782440
references: Hum Genet. 2012 Jul;131(7):1187-95
references: 22362486
references: Psychiatry Res. 2002 Jul 31;110(3):249-57
references: 12127475
references: Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1072-7
references: 17459549
references: Psychopharmacology (Berl). 2009 Dec;207(3):375-80
references: 19787338
references: Psychopharmacology (Berl). 2005 Jul;180(2):191-205
references: 15864560
references: Curr Opin Psychiatry. 2011 Mar;24(2):122-7
references: 21248641
references: Schizophr Res. 2006 Feb 15;82(1):95-106
references: 16442781
references: Neuropsychopharmacology. 2003 Feb;28(2):397-401
references: 12589394
references: Ann Neurol. 2002 Jan;51(1):133-6
references: 11782995
references: Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):254-9
references: 9874805