title: Effects of three types of Japanese honey on full-thickness wound in mice.
abstract: Although many previous studies reported that honey promotes wound healing, no study has examined the effects of Japanese honey. The aim of this study was to investigate the effects of three types of Japanese honey, Acacia, Buckwheat flour, and Chinese milk vetch honey, on wound healing in comparison with hydrocolloid dressing. Circular full-thickness skin wounds were produced on male mice. Japanese honey or hydrocolloid dressing was applied daily to the mice for 14 days. The ratio of wound area for the hydrocolloid dressing group increased initially in the inflammatory and early proliferative phases and then decreased rapidly to heal with scarring. However, the ratios of wound area for the Japanese honey groups decreased in the inflammatory phase, increased in the proliferative phase, and decreased in the proliferative phase, and some wounds were not completely covered with new epithelium. These findings indicate that using Japanese honey alone has limited benefit, but since it reduces wound size in the inflammatory phase, it is possible to apply a combined treatment in which Japanese honey is applied only in the inflammatory phase, followed by hydrocolloid dressing from the proliferative phase, which would effectively contract the wound.
authors: Graduate Course of Nursing Science, Division of Health Sciences, Department of Clinical Nursing, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors: Yukari
authors: Y
authors: Nakajima
authors: Yuki
authors: Y
authors: Nakano
authors: Sono
authors: S
authors: Fuwano
authors: Natsumi
authors: N
authors: Hayashi
authors: Yukiho
authors: Y
authors: Hiratoko
authors: Ayaka
authors: A
authors: Kinoshita
authors: Megumi
authors: M
authors: Miyahara
authors: Tsuyoshi
authors: T
authors: Mochizuki
authors: Kasumi
authors: K
authors: Nishino
authors: Yusuke
authors: Y
authors: Tsuruhara
authors: Yoshika
authors: Y
authors: Yokokawa
authors: Terumi
authors: T
authors: Iuchi
authors: Yuka
authors: Y
authors: Kon
authors: Kanae
authors: K
authors: Mukai
authors: Yukie
authors: Y
authors: Kitayama
authors: Naoko
authors: N
authors: Murakado
authors: Mayumi
authors: M
authors: Okuwa
authors: Toshio
authors: T
authors: Nakatani
references: Am J Pathol. 2011 Jan;178(1):19-25
references: 21224038
references: Wounds. 2010 Nov;22(11):275-83
references: 25901517
references: J Antimicrob Chemother. 2006 Oct;58(4):773-7
references: 16963460
references: J Wound Care. 1999 Sep;8(8):415-8
references: 10808853
references: Wounds. 2012 Apr;24(4):110-9
references: 25876247
references: Evid Based Complement Alternat Med. 2011;2011:908743
references: 19141489
references: Front Physiol. 2011 Nov 29;2:89
references: 22164144
references: BMC Complement Altern Med. 2010 Sep 03;10:48
references: 20815896
references: J Pharm Pharmacol. 1983 Nov;35(11):748-9
references: 6139459
references: Wound Repair Regen. 2009 Jul-Aug;17(4):598-605
references: 19614925
references: Zentralbl Veterinarmed A. 1998 Apr;45(3):181-8
references: 9673575
references: Front Biosci. 2004 Jan 01;9:283-9
references: 14766366
references: Int J Low Extrem Wounds. 2006 Mar;5(1):40-54
references: 16543212
references: Evid Based Complement Alternat Med. 2012;2012:843025
references: 21941590
references: Afr Health Sci. 2007 Sep;7(3):159-65
references: 18052870
references: Khirurgiia (Sofiia). 1961;14:937-46
references: 14455704
references: Experientia. 1971 May 15;27(5):549-50
references: 5132594
references: Anat Sci Int. 2007 Sep;82(3):147-55
references: 17867341
references: Surg Clin North Am. 1997 Jun;77(3):509-28
references: 9194878
references: BMC Complement Altern Med. 2001;1:2
references: 11405898
references: Am J Clin Dermatol. 2001;2(1):13-9
references: 11702616
references: Evid Based Complement Alternat Med. 2012;2012:109636
references: 22919407
references: Am J Surg. 1983 Mar;145(3):374-6
references: 6837863
references: Phytother Res. 2010 Apr;24(4):583-6
references: 19813239