title: Outcome of pure mucocele-like lesions diagnosed on breast core biopsy.
abstract: OBJECTIVE
  Current guidelines recommend that mucocele-like lesions (MLL) of the breast diagnosed on needle core biopsy (NCB) should be categorized as a lesion of uncertain malignant potential (B3). However, data on the outcome of MLL diagnosed on NCB remains limited due to the rarity of this lesion. The aim of this study was to assess the outcome of pure MLL without atypia diagnosed on NCB using a large series of cases and a review of the literature to provide evidence that can guide management.
  
  
  RESULTS
  Patients who underwent diagnostic excision biopsy after a core biopsy diagnosis of MLL without atypia were identified from several centres. Two of 54 patients (4%) with MLL without atypia on core biopsy had ductal carcinoma in situ in the subsequent excision specimen. This is similar to the rate in previous studies of 4% (four of 106). If there is atypia in the core biopsy, previous studies found that the frequency of malignancy is much higher at 21% (seven of 33).
  
  
  CONCLUSIONS
  Our results provide evidence that pure MLL without atypia diagnosed on NCB is usually associated with a benign outcome.
authors: Department of Histopathology, Nottingham University, Nottingham, UK. emadrakha@yahoo.com
authors: Emad A
authors: EA
authors: Rakha
authors: Abeer M
authors: AM
authors: Shaaban
authors: Syeda Asma
authors: SA
authors: Haider
authors: Jacquie
authors: J
authors: Jenkins
authors: Sindhu
authors: S
authors: Menon
authors: Christopher
authors: C
authors: Johnson
authors: Rin
authors: R
authors: Yamaguchi
authors: Alison
authors: A
authors: Murphy
authors: Joyce
authors: J
authors: Liston
authors: Eleanor
authors: E
authors: Cornford
authors: Lisa
authors: L
authors: Hamilton
authors: Jonathan
authors: J
authors: James
authors: Ian O
authors: IO
authors: Ellis
authors: Andrew H S
authors: AH
authors: Lee
mesh_terms: D000328:Adult; D000368:Aged; D062005:Biopsy, Large-Core Needle; D047688:Breast Cyst / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009078:Mucocele / Q000175:diagnosis / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult