title: Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense.
abstract: Intestinal mononuclear phagocytes have collectively emerged as key players in the maintenance of gut homeostasis, the development of gut inflammation and its resolution. Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria-resident CD103(+) dendritic cells and CX3CR1(+) macrophages. In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD).
authors: Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
authors: Julia
authors: J
authors: Farache
authors: Ehud
authors: E
authors: Zigmond
authors: Guy
authors: G
authors: Shakhar
authors: Steffen
authors: S
authors: Jung
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D000073883:CX3C Chemokine Receptor 1; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000473:pathology; D039001:Integrin alpha Chains / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D019707:Receptors, Chemokine / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D039001:Integrin alpha Chains; D019707:Receptors, Chemokine; C091367:alpha E integrins