title: Alginate-based microcapsules with a molecule recognition linker and photosensitizer for the combined cancer treatment.
abstract: A reactive template method was used to fabricate alginate-based hydrogel microcapsules. The uniform and well-dispersed hydrogel capsules have a high drug loading capacity. After they are coated by a folate-linked lipid mixture on the surface, the capsules possess higher cell uptake efficiency by the molecule recognition between folate and the folate-receptor overexpressed by the cancer cells. Moreover, in this bioconjugate, the lipid could remarkably reduce the release rate of hydrophilic doxorubicin from the hydrogel microcapsules and encapsulate the hydrophobic photosensitizer hypocrellin B. The biointerfaced capsules could be used as drug carriers for combined treatment against cancer cell proliferation in vitro; this was much more effective than chemotherapy or photodynamic therapy alone.
authors: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China.
authors: Cuiling
authors: C
authors: Du
authors: Jie
authors: J
authors: Zhao
authors: Jinbo
authors: J
authors: Fei
authors: Liang
authors: L
authors: Gao
authors: Wei
authors: W
authors: Cui
authors: Yang
authors: Y
authors: Yang
authors: Junbai
authors: J
authors: Li
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006367:HeLa Cells; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D010569:Perylene / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000633:toxicity; D011809:Quinones / Q000008:administration & dosage* / Q000633:toxicity
chemical_list: D000464:Alginates; D002214:Capsules; D004337:Drug Carriers; D006603:Hexuronic Acids; D017319:Photosensitizing Agents; D011809:Quinones; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010569:Perylene; D004317:Doxorubicin; D020723:Glucuronic Acid; C064522:hypocrellin B