title: A case of alveolar soft part sarcoma of the pleura.
abstract: Alveolar soft part sarcoma (ASPS) is a rare malignant soft-tissue neoplasm of unknown histogenesis. The two main sites of occurrence are the lower extremities in adults and the head and neck in children. We report the first case of pleural ASPS occurring in a 58-yr-old man who presented with progressive dyspnea. A computed tomographic scan of the thorax revealed a large enhancing pleural mass with pleural effusion in the left hemithorax. Wide excision of the pleural mass was performed. Histologically, the tumor consisted of organoid nests of large polygonal cells, the cytoplasm of which had eosinophilic and D-PAS positive granules. Immunohistochemical staining showed that the tumor cell nuclei were positive for transcription factor 3 (TFE3). The pleural ASPS with multiple bone metastases recurred 1 yr after surgery and the patient died of acute pulmonary embolism 1.5 yr after diagnosis.
authors: Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea.
authors: Hyeong Uk
authors: HU
authors: Ju
authors: Kwang Won
authors: KW
authors: Seo
authors: Yangjin
authors: Y
authors: Jegal
authors: Jong-Joon
authors: JJ
authors: Ahn
authors: Young Jik
authors: YJ
authors: Lee
authors: Young Min
authors: YM
authors: Kim
authors: Chulho
authors: C
authors: Oak
authors: Seung Won
authors: SW
authors: Ra
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary; D004417:Dyspnea / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D010994:Pleura / Q000503:physiopathology; D049268:Positron-Emission Tomography; D011655:Pulmonary Embolism / Q000175:diagnosis; D018234:Sarcoma, Alveolar Soft Part / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed; D058127:Transcription Factor 3 / Q000378:metabolism
chemical_list: D058127:Transcription Factor 3
keywords: Alveolar Soft Part Sarcoma; Pleura
references: Am J Surg Pathol. 2003 Jun;27(6):750-61
references: 12766578
references: Ann Pathol. 1996;16(1):49-52
references: 8652002
references: Rev Mal Respir. 2009 Mar;26(3):329-32
references: 19367208
references: J Clin Pathol. 2006 Nov;59(11):1127-32
references: 17071801
references: Ultrastruct Pathol. 1993 May-Aug;17(3-4):279-86
references: 8266593
references: Cancer. 1989 Jan 1;63(1):1-13
references: 2642727
references: Oncogene. 2001 Jan 4;20(1):48-57
references: 11244503
references: Arch Pathol Lab Med. 2007 Mar;131(3):488-91
references: 17516754
references: Cancer. 1964 Jul;17:821-30
references: 14179547
references: Cancer. 1952 Jan;5(1):100-11
references: 14886902
references: Eur J Cancer. 2003 Jul;39(11):1511-6
references: 12855256
references: J Korean Med Sci. 2007 Apr;22(2):369-72
references: 17449953
references: Acta Pathol Jpn. 1991 Oct;41(10):771-7
references: 1812692
references: Hum Pathol. 1982 Jun;13(6):569-79
references: 7076238