title: Inter-individual differences in response to dietary intervention: integrating omics platforms towards personalised dietary recommendations.
abstract: Technologic advances now make it possible to collect large amounts of genetic, epigenetic, metabolomic and gut microbiome data. These data have the potential to transform approaches towards nutrition counselling by allowing us to recognise and embrace the metabolic, physiologic and genetic differences among individuals. The ultimate goal is to be able to integrate these multi-dimensional data so as to characterise the health status and disease risk of an individual and to provide personalised recommendations to maximise health. To this end, accurate and predictive systems-based measures of health are needed that incorporate molecular signatures of genes, transcripts, proteins, metabolites and microbes. Although we are making progress within each of these omics arenas, we have yet to integrate effectively multiple sources of biologic data so as to provide comprehensive phenotypic profiles. Observational studies have provided some insights into associative interactions between genetic or phenotypic variation and diet and their impact on health; however, very few human experimental studies have addressed these relationships. Dietary interventions that test prescribed diets in well-characterised study populations and that monitor system-wide responses (ideally using several omics platforms) are needed to make correlation-causation connections and to characterise phenotypes under controlled conditions. Given the growth in our knowledge, there is the potential to develop personalised dietary recommendations. However, developing these recommendations assumes that an improved understanding of the phenotypic complexities of individuals and their responses to the complexities of their diets will lead to a sustainable, effective approach to promote health and prevent disease - therein lies our challenge.
authors: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. jlampe@fhcrc.org
authors: Johanna W
authors: JW
authors: Lampe
authors: Sandi L
authors: SL
authors: Navarro
authors: Meredith A J
authors: MA
authors: Hullar
authors: Ali
authors: A
authors: Shojaie
mesh_terms: D004032:Diet; D005247:Feeding Behavior; D020022:Genetic Predisposition to Disease; D006801:Humans; D007206:Individuality; D055432:Metabolomics / Q000379:methods*
references: BMC Bioinformatics. 2009 Aug 11;10:246
references: 19671149
references: PLoS Genet. 2012;8(7):e1002805
references: 22829776
references: Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9309-14
references: 15184677
references: J Proteome Res. 2009 Nov;8(11):5060-8
references: 19754154
references: Cell Host Microbe. 2011 Oct 20;10(4):324-35
references: 22018233
references: J Nutr. 2012 Jul;142(7):1259-65
references: 22649263
references: Nutr J. 2011 Jan 27;10:11
references: 21272319
references: Science. 2006 Jun 2;312(5778):1355-9
references: 16741115
references: Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):1987-8
references: 15598751
references: Stat Appl Genet Mol Biol. 2010;9:Article22
references: 20597848
references: BMC Bioinformatics. 2011 Nov 25;12:459
references: 22118224
references: Eur J Nutr. 2006 Sep;45(6):335-41
references: 16763747
references: Nat Genet. 2008 Dec;40(12):1426-35
references: 19011631
references: Br J Nutr. 2011 May;105(10):1492-502
references: 21272402
references: Am J Clin Nutr. 1998 Jan;67(1):136-42
references: 9440388
references: J Proteome Res. 2007 Nov;6(11):4469-77
references: 17929959
references: Cancer Res. 2002 Aug 1;62(15):4427-33
references: 12154050
references: PLoS Genet. 2012;8(3):e1002491
references: 22423221
references: Nat Rev Microbiol. 2012 Jul 16;10(8):538-50
references: 22796884
references: J Nutr. 2012 Jun;142(6):1009-18
references: 22513989
references: Cancer Res. 2011 Dec 15;71(24):7376-86
references: 21990318
references: J Nutr. 2007 Nov;137(11):2391-8
references: 17951475
references: J Nutr Biochem. 2007 Jun;18(6):380-90
references: 16963248
references: Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10205-10
references: 15199185
references: Lancet. 2003 Feb 8;361(9356):512-9
references: 12583961
references: PLoS One. 2011;6(7):e21417
references: 21789170
references: Nat Genet. 2011 Jun;43(6):565-9
references: 21572414
references: Nat Genet. 2008 May;40(5):638-45
references: 18372903
references: PLoS One. 2011;6(5):e20447
references: 21647227
references: BMC Bioinformatics. 2009 Jan 26;10:34
references: 19171069
references: Nature. 2010 Mar 4;464(7285):59-65
references: 20203603
references: PLoS Comput Biol. 2012;8(7):e1002606
references: 22807668
references: Biostatistics. 2012 Sep;13(4):748-61
references: 22699861
references: Nature. 2006 Dec 21;444(7122):1022-3
references: 17183309
references: Nutr Metab (Lond). 2011 Dec 17;8:90
references: 22177085
references: Genome Res. 2012 Oct;22(10):1974-84
references: 22665442
references: J Biol Chem. 2005 Jul 8;280(27):25590-5
references: 15866872
references: Nat Genet. 2012 Dec;44(12):1355-9
references: 23104006
references: Metabolomics. 2009;5(2):209-218
references: 20442800
references: Public Health Genomics. 2012;15(3-4):139-45
references: 22488456
references: Am J Clin Nutr. 2007 Dec;86(6):1687-93
references: 18065587
references: Cancer Epidemiol Biomarkers Prev. 2011 Jun;20(6):1107-11
references: 21527577
references: Mol Cell Biol. 1999 Mar;19(3):1720-30
references: 10022859
references: Curr Opin Lipidol. 2006 Apr;17(2):157-61
references: 16531752
references: J Proteome Res. 2010 Nov 5;9(11):5859-67
references: 20853910
references: Br J Nutr. 2007 Apr;97(4):758-63
references: 17349089
references: Am J Clin Nutr. 2011 May;93(5):1062-72
references: 21389180
references: J Agric Food Chem. 2012 Nov 14;60(45):11331-42
references: 23072624
references: J Nutr. 2012 Feb;142(2):369-74
references: 22190020
references: Breast Cancer Res. 2008;10(4):R65
references: 18662380
references: Nature. 2012 Oct 4;490(7418):55-60
references: 23023125
references: J Nutr. 2011 Dec;141(12):2126-32
references: 22013201
references: Br J Nutr. 2006 Feb;95(2):372-8
references: 16469156
references: J Nutr. 2005 Jul;135(7):1613-6
references: 15987837
references: PLoS Genet. 2008 Nov;4(11):e1000282
references: 19043545
references: Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2974-8
references: 19900941
references: Gastroenterology. 2010 Dec;139(6):1844-1854.e1
references: 20816835
references: Nat Genet. 2008 Dec;40(12):1399-401
references: 18978792
references: J Cell Physiol. 2012 Sep;227(9):3169-77
references: 22261928
references: J Nutr. 2009 Sep;139(9):1685-91
references: 19640972
references: Annu Rev Nutr. 2012 Aug 21;32:183-202
references: 22540256
references: J Proteome Res. 2006 Oct;5(10):2780-8
references: 17022649
references: Nature. 2011 May 12;473(7346):174-80
references: 21508958
references: J Proteome Res. 2011 Nov 4;10(11):5047-58
references: 21905751
references: Br J Nutr. 2008 Jan;99(1):110-20
references: 17761020
references: Mol Cell Proteomics. 2012 Jun;11(6):M111.014910
references: 22240506
references: Appl Environ Microbiol. 2007 Feb;73(4):1073-8
references: 17189447
references: J Proteome Res. 2012 Feb 3;11(2):643-55
references: 21999107
references: Nutrients. 2012 Feb;4(2):112-31
references: 22413065
references: J Nutr Biochem. 2005 Apr;16(4):236-44
references: 15808328
references: Am J Clin Nutr. 2010 Aug;92(2):436-43
references: 20573794
references: Br J Nutr. 2001 Sep;86(3):341-8
references: 11570986
references: Drug Metab Dispos. 2011 Sep;39(9):1650-7
references: 21666065
references: J Agric Food Chem. 2006 Sep 6;54(18):6929-38
references: 16939360
references: Cell Metab. 2011 May 4;13(5):517-26
references: 21531334
references: Curr Opin Biotechnol. 2013 Apr;24(2):220-5
references: 23040410