title: Perspectives on natural product epigenetic modulators in chemical biology and medicine.
abstract: Epigenetic processes are complex regulatory transcriptional pathways that underpin fundamental physiology and are implicated in the aetiology of many diseases. Small molecule modulators of key epigenetic targets will be central in the study of these intricate networks as well as providing highly useful start points for drug discovery efforts. In this review we will give our perspective on the current status of natural product epigenetic modulators, highlighting the limitations, challenges and opportunities for currently identified molecules, as well as potential strategies for novel compound discovery moving forward.
authors: Department of Chemistry, Imperial College London, London SW7 2AZ, UK.
authors: Fanny L
authors: FL
authors: Cherblanc
authors: Robert W M
authors: RW
authors: Davidson
authors: Paolo
authors: P
authors: Di Fruscia
authors: Nitipol
authors: N
authors: Srimongkolpithak
authors: Matthew J
authors: MJ
authors: Fuchter
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D055808:Drug Discovery; D057890:Epigenomics; D015394:Molecular Structure
chemical_list: D001688:Biological Products