title: Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans.
abstract: Little is known about the associations of FADS1 genetic variants with circulating levels of PUFA and lipids in Asian populations who have a different dietary pattern and dyslipidemia prevalence compared with Western populations. In a population-based sample of 3,210 unrelated Han Chinese living in Beijing and Shanghai, we examined a FADS1 genetic variant, rs174550, in relation to blood PUFA and lipid levels. C-allele of rs174550 was significantly associated with levels of erythrocyte PUFAs in upstream and downstream pathways of delta-5 desaturase (D5D) (P ≤ 0.003). Moreover, rs174550 C-allele was associated with a lower HDL cholesterol level (P = 0.02) in total population and a higher triglyceride level (P = 0.0002) in Beijing residents. Interestingly, erythrocyte levels of 18:2n-6 and 18:3n-3 modified the effect of rs174550 on HDL cholesterol level: stronger associations between rs174550 C-allele and lower HDL cholesterol levels were exhibited when erythrocyte 18:2n-6 or 18:3n-3 level was low (P for interaction = 0.02 and 0.03, respectively). These data suggested that FADS1 genetic variant was associated with circulating PUFA and lipid levels and that its effect on HDL cholesterol might depend on PUFA status in the Han Chinese population.
authors: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors: Jingwen
authors: J
authors: Zhu
authors: Qi
authors: Q
authors: Sun
authors: Geng
authors: G
authors: Zong
authors: Yuan
authors: Y
authors: Si
authors: Chen
authors: C
authors: Liu
authors: Qibin
authors: Q
authors: Qi
authors: Xingwang
authors: X
authors: Ye
authors: Liang
authors: L
authors: Sun
authors: Hongguang
authors: H
authors: Sheng
authors: Huaixing
authors: H
authors: Li
authors: Xu
authors: X
authors: Lin
mesh_terms: D000368:Aged; D000483:Alleles; D002681:China; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D000090943:Delta-5 Fatty Acid Desaturase; D004912:Erythrocytes / Q000737:chemistry; D044943:Fatty Acid Desaturases / Q000235:genetics*; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged
chemical_list: D008076:Cholesterol, HDL; D000090943:Delta-5 Fatty Acid Desaturase; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human
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