title: Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions.
abstract: Non-enzymatic modification of aminophospholipids by lipid  peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes and to the pathogenesis of diabetic complications. Much evidence demonstrates the modification of aminophospholipids by glycation, glycoxidation and lipoxidation reactions. Therefore, a number of early and advanced Maillard reaction-lipid products have been detected and quantified in different biological membranes. These modifications may be accumulated during aging and diabetes, introducing changes in cell membrane physico-chemical and biological properties.
authors: Department of Experimental Medicine, Faculty of Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida E25198, Catalonia, Spain. reinald.pamplona@mex.udl.cat.
authors: Alba
authors: A
authors: Naudí
authors: Mariona
authors: M
authors: Jové
authors: Victòria
authors: V
authors: Ayala
authors: Rosanna
authors: R
authors: Cabré
authors: Manuel
authors: M
authors: Portero-Otín
authors: Reinald
authors: R
authors: Pamplona
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