title: Nocapyrones H-J, 3,6-disubstituted α-pyrones from the marine actinomycete Nocardiopsis sp. KMF-001.
abstract: Three new 3,6-disubstituted α-pyrones, nocapyrones H-J (1-3), were isolated from the marine actinomycete Nocardiopsis sp. KMF-001. Their structures were assigned to be 3-alkylated 6-(1-methyl-1-propenyl)-2H-pyran-2-ones on the basis of UV, MS, NMR, and high resolution (HR)-FAB-MS analyses. Nocapyrone H (1) reduced the pro-inflammatory factor such as nitric oxide (NO), prostaglandin E(2) (PGE(2)) and interleukin-1β (IL-1β). Moreover, nocapyrone H showed 5.82% stronger inhibitory effect on NO production than chrysin at a concentration of 10 µM in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.
authors: Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung, Gangwon-do 210-340, Republic of Korea.
authors: Min Cheol
authors: MC
authors: Kim
authors: Oh-Wook
authors: OW
authors: Kwon
authors: Jin-Soo
authors: JS
authors: Park
authors: Sun Yeou
authors: SY
authors: Kim
authors: Hak Cheol
authors: HC
authors: Kwon
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D009615:Nocardia / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D011753:Pyrones; D009569:Nitric Oxide