title: In vivo functional brain mapping in a conditional mouse model of human tauopathy (tauP301L) reveals reduced neural activity in memory formation structures.
abstract: BACKGROUND
  Tauopathies are characterized by intracellular deposition of the microtubule-associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally expresses mutant human tau protein in various forebrain areas under the Tet-off expression system. Mice develop neurofibrillary tangles, with significant neuronal loss and cognitive deficits by 6 months of age. Previous behavioral and biochemical work has linked the expression and aggregates of mutant tau to functional impairments. The present work used manganese-enhanced magnetic resonance imaging (MEMRI) to investigate basal levels of brain activity in the rTg4510 and control mice.
  
  
  RESULTS
  Our results show an unmistakable curtailment of neural activity in the amygdala and hippocampus, two regions known for their role in memory formation, but not the cortex, cerebellum, striatum and hypothalamus in tau expressing mice.
  
  
  CONCLUSIONS
  Behavioral impairments associated with changes in activity in these areas may correspond to age progressive mutant tau(P301L)-induced neurodegeneration.
authors: Department of Psychiatry, University of Florida McKnight Brain Institute, Gainesville, Florida 32610, USA.
authors: Pablo D
authors: PD
authors: Perez
authors: Gabrielle
authors: G
authors: Hall
authors: Tetsuya
authors: T
authors: Kimura
authors: Yan
authors: Y
authors: Ren
authors: Rachel M
authors: RM
authors: Bailey
authors: Jada
authors: J
authors: Lewis
authors: Marcelo
authors: M
authors: Febo
authors: Naruhiko
authors: N
authors: Sahara
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008568:Memory / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D024801:Tauopathies / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D016875:tau Proteins
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