title: Detection of error related neuronal responses recorded by electrocorticography in humans during continuous movements.
abstract: BACKGROUND
  Brain-machine interfaces (BMIs) can translate the neuronal activity underlying a user's movement intention into movements of an artificial effector. In spite of continuous improvements, errors in movement decoding are still a major problem of current BMI systems. If the difference between the decoded and intended movements becomes noticeable, it may lead to an execution error. Outcome errors, where subjects fail to reach a certain movement goal, are also present during online BMI operation. Detecting such errors can be beneficial for BMI operation: (i) errors can be corrected online after being detected and (ii) adaptive BMI decoding algorithm can be updated to make fewer errors in the future.
  
  
  RESULTS
  Here, we show that error events can be detected from human electrocorticography (ECoG) during a continuous task with high precision, given a temporal tolerance of 300-400 milliseconds. We quantified the error detection accuracy and showed that, using only a small subset of 2×2 ECoG electrodes, 82% of detection information for outcome error and 74% of detection information for execution error available from all ECoG electrodes could be retained.
  
  
  CONCLUSIONS
  The error detection method presented here could be used to correct errors made during BMI operation or to adapt a BMI algorithm to make fewer errors in the future. Furthermore, our results indicate that smaller ECoG implant could be used for error detection. Reducing the size of an ECoG electrode implant used for BMI decoding and error detection could significantly reduce the medical risk of implantation.
authors: Bernstein Center Freiburg, University of Freiburg, Freiburg, Germany. Tomislav_Milekovic@brown.edu
authors: Tomislav
authors: T
authors: Milekovic
authors: Tonio
authors: T
authors: Ball
authors: Andreas
authors: A
authors: Schulze-Bonhage
authors: Ad
authors: A
authors: Aertsen
authors: Carsten
authors: C
authors: Mehring
mesh_terms: D000465:Algorithms; D062207:Brain-Computer Interfaces / Q000592:standards*; D002540:Cerebral Cortex / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D019736:Prostheses and Implants; D011597:Psychomotor Performance / Q000502:physiology
references: J Comput Neurosci. 2010 Aug;29(1-2):73-87
references: 19904595
references: J Neurosci. 2009 Nov 11;29(45):14363-70
references: 19906983
references: J Neural Eng. 2011 Apr;8(2):025027
references: 21436513
references: Biol Cybern. 2006 Sep;95(3):243-57
references: 16802156
references: Neurosci Biobehav Rev. 2009 Jan;33(1):48-60
references: 18789964
references: Front Comput Neurosci. 2010 Mar 19;4:4
references: 20428513
references: Clin Neurophysiol. 2008 Jan;119(1):116-33
references: 18037343
references: Front Neuroeng. 2009 Jul 14;2:11
references: 19636394
references: Brain. 1998 Dec;121 ( Pt 12):2301-15
references: 9874481
references: Int J Psychophysiol. 2003 May;48(2):141-6
references: 12763571
references: Electroencephalogr Clin Neurophysiol. 1991 Jun;78(6):447-55
references: 1712280
references: IEEE Trans Rehabil Eng. 2000 Jun;8(2):180-5
references: 10896180
references: Trends Neurosci. 2007 Jul;30(7):317-24
references: 17499860
references: Neuroimage. 2012 Jan 2;59(1):248-60
references: 21763434
references: Brain. 1998 Dec;121 ( Pt 12):2271-99
references: 9874480
references: BMC Neurosci. 2012 Feb 15;13:19
references: 22336293
references: IEEE Trans Neural Syst Rehabil Eng. 2003 Jun;11(2):127-31
references: 12899253
references: IEEE Trans Neural Syst Rehabil Eng. 2006 Jun;14(2):164-8
references: 16792284
references: AJNR Am J Neuroradiol. 2005 May;26(5):1078-83
references: 15891163
references: Brain Res. 2007 Jun 25;1155:70-80
references: 17498670
references: Med Biol Eng Comput. 2010 Mar;48(3):245-53
references: 19888613
references: IEEE Trans Biomed Eng. 2008 Mar;55(3):923-9
references: 18334383
references: Clin Neurophysiol. 2000 Dec;111(12):2138-44
references: 11090763
references: Nature. 2006 Jul 13;442(7099):164-71
references: 16838014
references: J Neurosci. 2003 May 15;23(10):4308-14
references: 12764119
references: Neuroscience. 2006;137(1):13-7
references: 16343779
references: J Neurosci Methods. 2008 Oct 30;175(1):148-53
references: 18761037
references: Clin Neurophysiol. 2001 Apr;112(4):565-82
references: 11275528
references: J Clin Neurophysiol. 2007 Apr;24(2):137-46
references: 17414969
references: Neural Comput. 2000 Dec;12(12):2797-804
references: 11112255
references: Comput Intell Neurosci. 2007;:84386
references: 18288260
references: Hum Brain Mapp. 2010 Aug;31(8):1217-32
references: 20120013
references: PLoS Biol. 2003 Nov;1(2):E42
references: 14624244
references: IEEE Rev Biomed Eng. 2011;4:140-54
references: 22273796
references: Nat Neurosci. 2004 May;7(5):549-54
references: 15107858
references: J Physiol Paris. 2003 Jul-Nov;97(4-6):613-28
references: 15242670
references: Neuroimage. 2008 Apr 1;40(2):767-775
references: 18234516
references: Prog Brain Res. 2006;159:275-95
references: 17071238
references: IEEE Trans Neural Syst Rehabil Eng. 2003 Jun;11(2):173-7
references: 12899266
references: Stroke. 2008 Dec;39(12):3351-9
references: 18927456
references: J Clin Neurophysiol. 2008 Jun;25(3):119-31
references: 18469727
references: J Neural Eng. 2009 Feb;6(1):016006
references: 19155551
references: IEEE Trans Biomed Eng. 2012 Apr;59(4):1125-34
references: 22271828
references: Neuropsychologia. 2004;42(10):1383-93
references: 15193946
references: Front Neuroeng. 2010 Mar 30;3:3
references: 20407639
references: Nature. 2008 Jun 19;453(7198):1098-101
references: 18509337
references: Front Neurosci. 2012 Nov 16;6:164
references: 23162425
references: Science. 2002 Jun 7;296(5574):1829-32
references: 12052948
references: Nat Neurosci. 2004 Nov;7(11):1259-65
references: 15494729
references: J Cogn Neurosci. 1997 Nov;9(6):788-98
references: 23964600
references: Anal Chem. 1972 Sep 1;44(11):1906-9
references: 22324618
references: Int J Psychophysiol. 2005 Nov-Dec;58(2-3):227-34
references: 16169106
references: J Neural Eng. 2004 Jun;1(2):63-71
references: 15876624
references: Clin EEG Neurosci. 2006 Oct;37(4):330-5
references: 17073172
references: Neuropsychologia. 2008 Jan 15;46(1):117-26
references: 17900633
references: J Neural Eng. 2008 Dec;5(4):455-76
references: 19015583
references: Front Neuroeng. 2010 Jun 24;3:9
references: 20631853
references: Nature. 2012 May 16;485(7398):372-5
references: 22596161
references: J Neural Eng. 2010 Jun;7(3):036007
references: 20460690
references: Exp Brain Res. 2008 Oct;190(4):401-11
references: 18629483
references: Curr Opin Neurobiol. 2010 Dec;20(6):741-5
references: 20952183
references: Annu Int Conf IEEE Eng Med Biol Soc. 2007;2007:2536-9
references: 18002511
references: J Neural Eng. 2008 Mar;5(1):75-84
references: 18310813
references: Psychophysiology. 2007 Jul;44(4):586-95
references: 17437555
references: J Neural Eng. 2007 Sep;4(3):336-47
references: 17873435
references: J Neurosci. 2005 Oct 26;25(43):9919-31
references: 16251440
references: J Neural Eng. 2009 Dec;6(6):066001
references: 19794237
references: Nature. 2002 Mar 14;416(6877):141-2
references: 11894084
references: J Neural Eng. 2012 Apr;9(2):026007
references: 22326993
references: IEEE Trans Biomed Eng. 2008 Oct;55(10):2452-62
references: 18838371
references: IEEE Trans Neural Syst Rehabil Eng. 2005 Sep;13(3):372-9
references: 16200760
references: Hum Brain Mapp. 2009 Jun;30(6):1758-71
references: 19343801
references: IEEE Trans Biomed Eng. 2009 Jan;56(1):54-64
references: 19224719
references: Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:586-9
references: 19964229
references: Acta Neurochir (Wien). 2009 Jan;151(1):37-50
references: 19129963
references: J Neural Eng. 2012 Aug;9(4):046003
references: 22713666