title: In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass.
abstract: In order to enhance the corrosion resistance of the Ca65Mg15Zn20 bulk metallic glass, which has too fast a degradation rate for biomedical applications, we fabricated the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass because of the unique properties of high-entropy alloys. Our results showed that the mechanical properties and corrosion behavior were enhanced. The in vitro tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass could stimulate the proliferation and differentiation of cultured osteoblasts. The in vivo animal tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass did not show any obvious degradation after 4 weeks of implantation, and they can promote osteogenesis and new bone formation after 2 weeks of implantation. The improved mechanical properties and corrosion behavior can be attributed to the different chemical composition as well as the formation of a unique high-entropy atomic structure with a maximum degree of disorder.
authors: State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors: H F
authors: HF
authors: Li
authors: X H
authors: XH
authors: Xie
authors: K
authors: K
authors: Zhao
authors: Y B
authors: YB
authors: Wang
authors: Y F
authors: YF
authors: Zheng
authors: W H
authors: WH
authors: Wang
authors: L
authors: L
authors: Qin
mesh_terms: D000497:Alloys / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002152:Calorimetry, Differential Scanning; D002460:Cell Line; D003343:Corrosion; D055664:Electrochemical Techniques; D019277:Entropy; D005269:Femur / Q000000981:diagnostic imaging / Q000187:drug effects; D005898:Glass / Q000737:chemistry*; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D021621:Imaging, Three-Dimensional; D007477:Ions / Q000032:analysis; D008422:Materials Testing; D055595:Mechanical Phenomena / Q000187:drug effects; D008670:Metals / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013052:Spectrometry, X-Ray Emission; D014961:X-Ray Diffraction; D055114:X-Ray Microtomography
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; C588234:Ca20Mg20Zn20Sr20Yb20 alloy; D007477:Ions; D008670:Metals; D006859:Hydrogen
keywords: Biodegradable metals; Bone; Bulk metallic glasses; Ca(20)Mg(20)Zn(20)Sr(20)Yb(20) alloy; High-entropy alloys