title: Developmental evidence for serial homology of the vertebrate jaw and gill arch skeleton.
abstract: Gegenbaur's classical hypothesis of jaw-gill arch serial homology is widely cited, but remains unsupported by either palaeontological evidence (for example, a series of fossils reflecting the stepwise transformation of a gill arch into a jaw) or developmental genetic data (for example, shared molecular mechanisms underlying segment identity in the mandibular, hyoid and gill arch endoskeletons). Here we show that nested expression of Dlx genes--the 'Dlx code' that specifies upper and lower jaw identity in mammals and teleosts--is a primitive feature of the mandibular, hyoid and gill arches of jawed vertebrates. Using fate-mapping techniques, we demonstrate that the principal dorsal and ventral endoskeletal segments of the jaw, hyoid and gill arches of the skate Leucoraja erinacea derive from molecularly equivalent mesenchymal domains of combinatorial Dlx gene expression. Our data suggest that vertebrate jaw, hyoid and gill arch cartilages are serially homologous, and were primitively patterned dorsoventrally by a common Dlx blueprint.
authors: Department of Physiology, Development and Neuroscience, University of Cambridge, Anatomy Building, Downing Street, Cambridge CB2 3DY, UK. andrew.gillis@dal.ca
authors: J Andrew
authors: JA
authors: Gillis
authors: Melinda S
authors: MS
authors: Modrell
authors: Clare V H
authors: CV
authors: Baker
mesh_terms: D000818:Animals; D001499:Bayes Theorem; D019521:Body Patterning / Q000235:genetics; D001934:Branchial Region / Q000033:anatomy & histology* / Q000196:embryology / Q000378:metabolism; D018940:Elasmobranchii / Q000033:anatomy & histology / Q000196:embryology / Q000235:genetics; D004625:Embryo, Nonmammalian / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D005880:Gills / Q000033:anatomy & histology* / Q000196:embryology* / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D007568:Jaw / Q000033:anatomy & histology* / Q000196:embryology*; D008322:Mammals / Q000033:anatomy & histology / Q000196:embryology; D008648:Mesoderm / Q000196:embryology / Q000378:metabolism; D008954:Models, Biological; D010802:Phylogeny; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014714:Vertebrates / Q000033:anatomy & histology* / Q000196:embryology* / Q000235:genetics
chemical_list: C088334:Distal-less homeobox proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors
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