title: Synthesis of pyrrolin-4-ones by Pt-catalyzed cycloisomerization in PEG under microwaves.
abstract: The unprecedented eco-friendly Pt-catalyzed 5-endo-dig cycloisomerization of readily available α-amino ynones is reported under microwave irradiation in PEG-3400 as reaction matrix. The corresponding pure pyrrolin-4-ones were obtained in excellent yields (80-98%) directly after a straightforward precipitation-filtration workup, thus avoiding any chromatographic purification. The catalytic system was recycled and the chiral purity of all the products was also investigated.
authors: Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM I-UM II, Université de Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5, France.
authors: Rosella
authors: R
authors: Spina
authors: Evelina
authors: E
authors: Colacino
authors: Bartolo
authors: B
authors: Gabriele
authors: Giuseppe
authors: G
authors: Salerno
authors: Jean
authors: J
authors: Martinez
authors: Frédéric
authors: F
authors: Lamaty
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D008872:Microwaves; D010984:Platinum / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D011758:Pyrroles; D011092:Polyethylene Glycols; D010984:Platinum