title: The degradation mechanism of toxic atractyloside in herbal medicines by decoction.
abstract: Atractyloside (ATR) is found in many Asteraceae plants that are commonly used as medicinal herbs in China and other eastern Asian countries. ATR binds specifically to the adenine nucleotide translocator in the inner mitochondrial membrane and competitively inhibits ADP and ATP transport. The toxicity of ATR in medical herbs can be reduced by hydrothermal processing, but the mechanisms of ATR degradation are not well understood. In this study, GC-MS coupled with SPE and TMS derivatisation was used to detect ATR levels in traditional Chinese medicinal herbs. Our results suggest that ATR molecules were disrupted by decomposition, hydrolysis and saponification after heating with water (decoction) for a long period of time. Hydrothermal processing could decompose the endogenous toxic compounds and also facilitate the detoxification of raw materials used in the Chinese medicine industry.
authors: Department of Biotechnology, Ming-Chuan University, Guishan, Taoyuan 333, Taiwan. loknath@mail.mcu.edu.tw
authors: Liang-Yu
authors: LY
authors: Chen
authors: Anren
authors: A
authors: Hu
authors: Chih-Jui
authors: CJ
authors: Chang
mesh_terms: D001278:Atractyloside / Q000737:chemistry* / Q000633:toxicity*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000633:toxicity*; D006868:Hydrolysis / Q000187:drug effects; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000737:chemistry*; D012015:Reference Standards; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D014867:Water; D001278:Atractyloside
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