title: New aspects of the physiology of the GH-IGF-1 axis.
abstract: Growth hormone (GH) secretion from the pituitary is regulated by a complex network of CNS and peripheral inputs. Circulating GH binds to its receptor and initiates a cascade of signaling events which involve the JAK2-STAT pathway, the PI3K/Akt pathway and the RAS/MAPK pathway, leading to the transcription of several genes, including insulin-like growth factor 1 (IGF-1), IGFBP3, ALS, and others. Recent findings indicate that nutrition plays an important role in GH secretion and action. Furthermore, data are emerging which suggest that the RAS-MAPK pathway as well as epigenetic regulation of transcription may be important in determining both circulating and locally produced IGF-1.
authors: Clinica Pediatrica, Università di Parma, Parma, Italia.
authors: Alessandra
authors: A
authors: Vottero
authors: Chiara
authors: C
authors: Guzzetti
authors: Sandro
authors: S
authors: Loche
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic / Q000502:physiology; D013006:Growth Hormone / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D009747:Nutritional Physiological Phenomena / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone