title: New horizon on successful management for a woman with repeated implantation failure due to unresponsive thin endometrium: use of extended estrogen supplementation.
abstract: An adequate thickness and pattern of the pre-ovulatory endometrium is considered one of the essential requirements for a successful pregnancy. Although various methods for increasing endometrial thickness have been proposed, the real value of these interventions remains controversial. Here, we present a case of successful administration of extended estrogen supplementation before conventional controlled ovarian hyperstimulation in a woman who had experienced repeated implantation failure because of an unresponsive thin endometrium. After the estrogen supplement was administrated for an extended period, the in vitro fertilization/embryo transfer in this patient led to an uneventful twin pregnancy and delivery at term.
authors: Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan.
authors: Meng-Shun
authors: MS
authors: Shen
authors: Chia-Woei
authors: CW
authors: Wang
authors: Chi-Huang
authors: CH
authors: Chen
authors: Chii-Ruey
authors: CR
authors: Tzeng
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011247:Pregnancy; D059285:Pregnancy, Twin; D013480:Superovulation; D047929:Term Birth
chemical_list: D004967:Estrogens; D004958:Estradiol