title: [Prolonged exposure to crystalline silica Min-U-Sil-5 influences apoptosis or extracellular matrix genes expression in human bronchial epithelial cells].
abstract: Crystalline silica (Min-U-Sil-5) induces oxidative stress in human bronchial epithelial cells (BEAS-2B), through the intracellular accumulation of ROS that cause oxidative damage leading to the degradation of extracellular matrix (ECM) proteins and to the loss of cell adhesion molecules inducing apoptosis and genotoxic damage. This paper briefly summarizes some of the recent findings from our laboratories with emphasis on the molecular events by which the cronic and cumulative exposure to crystalline silica can induce cellular damage that promotes changes in extracellular matrix and in apoptosis gene expression.
authors: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Medicina del Lavoro Malattie Respiratorie e Tossicologia Professionali e Ambiental Piazzale G. Menghini 3, Università degli Studi di Perugia, 06132 S. Andrea delle Fratte, Perugia, Italia. angela.gambelunghe@unipg.it
authors: A
authors: A
authors: Gambelunghe
authors: C
authors: C
authors: Antognelli
authors: N
authors: N
authors: Murgia
authors: M
authors: M
authors: dell'Omo
authors: V N
authors: VN
authors: Talesa
authors: G
authors: G
authors: Muzi
mesh_terms: D017209:Apoptosis; D001980:Bronchi / Q000166:cytology*; D002478:Cells, Cultured; D004847:Epithelial Cells; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D012822:Silicon Dioxide; D013997:Time Factors
chemical_list: D016326:Extracellular Matrix Proteins; D012822:Silicon Dioxide