title: Evolution of equine influenza virus in vaccinated horses.
abstract: Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naïve horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
authors: Medical Research Council-University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
authors: Pablo R
authors: PR
authors: Murcia
authors: Gregory J
authors: GJ
authors: Baillie
authors: J Conrad
authors: JC
authors: Stack
authors: Carley
authors: C
authors: Jervis
authors: Debra
authors: D
authors: Elton
authors: Jennifer A
authors: JA
authors: Mumford
authors: Janet
authors: J
authors: Daly
authors: Paul
authors: P
authors: Kellam
authors: Bryan T
authors: BT
authors: Grenfell
authors: Edward C
authors: EC
authors: Holmes
authors: James L N
authors: JL
authors: Wood
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D014644:Genetic Variation; D006734:Horse Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D006736:Horses; D053123:Influenza A Virus, H3N8 Subtype / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D012367:RNA, Viral / Q000235:genetics*; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral
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