title: Epigenetic mechanisms of drug addiction.
abstract: Epigenetic regulation can mediate long-lasting changes in gene expression, which makes it an attractive mechanism for the stable behavioral abnormalities that characterize drug addiction. Recent research has unveiled numerous types of epigenetic modifications within the brain's reward circuitry in animal models of drug addiction. In this review, we summarize the latest advances in the field, focusing on histone modifications, DNA methylation, and noncoding RNAs. We also highlight several areas for future research. Unraveling the highly complex epigenetic mechanisms of addiction is adding to our understanding of this syndrome and has the potential to trigger novel approaches for better diagnosis and therapy.
authors: Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1065, New York, NY 10029, United States.
authors: Jian
authors: J
authors: Feng
authors: Eric J
authors: EJ
authors: Nestler
mesh_terms: D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D015870:Gene Expression / Q000502:physiology*; D006657:Histones; D006801:Humans; D022661:RNA, Untranslated; D019966:Substance-Related Disorders / Q000235:genetics* / Q000378:metabolism*
chemical_list: D006657:Histones; D022661:RNA, Untranslated
references: Nat Rev Genet. 2009 May;10(5):295-304
references: 19308066
references: Science. 2009 May 15;324(5929):929-30
references: 19372393
references: Science. 2001 Aug 10;293(5532):1074-80
references: 11498575
references: Nature. 2010 Jul 8;466(7303):197-202
references: 20613834
references: Cell. 2011 Apr 29;145(3):423-34
references: 21496894
references: Nat Rev Neurosci. 2012 Jul 20;13(8):528-41
references: 22814587
references: Nat Rev Genet. 2009 Oct;10(10):669-80
references: 19736561
references: Neuron. 2005 Oct 20;48(2):303-14
references: 16242410
references: Neuropsychopharmacology. 2011 May;36(6):1149-64
references: 21307844
references: Nat Rev Neurosci. 2011 Oct 12;12(11):623-37
references: 21989194
references: Mol Cell Biol. 2012 Feb;32(3):619-32
references: 22144581
references: Nat Protoc. 2011 Sep 29;6(10):1656-68
references: 21959244
references: Genes Dev. 2011 Dec 1;25(23):2436-52
references: 22156206
references: Nat Neurosci. 2010 Sep;13(9):1128-36
references: 20711186
references: Science. 2010 Jan 8;327(5962):213-6
references: 20056891
references: J Neurochem. 2011 Feb;116(3):459-66
references: 21128942
references: Science. 2011 Sep 2;333(6047):1303-7
references: 21817016
references: Nat Neurosci. 2013 Apr;16(4):434-40
references: 23475113
references: Neuron. 2012 Jan 12;73(1):108-20
references: 22243750
references: BMC Neurosci. 2008 Apr 28;9:42
references: 18442397
references: Neuropsychopharmacology. 2009 Mar;34(4):867-73
references: 18650805
references: RNA. 2011 Aug;17(8):1529-43
references: 21708909
references: Nat Neurosci. 2010 Sep;13(9):1137-43
references: 20729844
references: Neuropsychopharmacology. 2013 Jan;38(1):94-110
references: 22910457
references: Science. 2003 Oct 31;302(5646):890-3
references: 14593184
references: Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3035-40
references: 21300862
references: Front Genet. 2012 Jun 22;3:106
references: 22737160
references: J Neurosci Res. 2005 Mar 15;79(6):734-46
references: 15672446
references: J Neurosci. 2012 Jul 25;32(30):10267-72
references: 22836260
references: Nat Protoc. 2011 Apr;6(4):468-81
references: 21412275
references: Nat Neurosci. 2011 Oct 30;14(12):1607-16
references: 22037496
references: Cell. 2011 Jan 7;144(1):16-26
references: 21215366
references: Science. 2003 Oct 31;302(5646):885-9
references: 14593183
references: Mol Cell Neurosci. 2009 Dec;42(4):350-62
references: 19703567
references: Nature. 2012 Sep 6;489(7414):57-74
references: 22955616
references: Science. 2009 May 15;324(5929):930-5
references: 19372391
references: Nat Rev Genet. 2009 Jan;10(1):57-63
references: 19015660
references: Neuropsychopharmacology. 2013 Jan;38(1):23-38
references: 22781841
references: Annu Rev Biochem. 2012;81:145-66
references: 22663078
references: Cell. 1999 Nov 24;99(5):451-4
references: 10589672
references: Neuron. 2007 Nov 8;56(3):517-29
references: 17988634
references: Neuropsychopharmacology. 2010 Nov;35(12):2450-61
references: 20720536
references: Nat Rev Neurosci. 2001 Feb;2(2):119-28
references: 11252991
references: Nat Genet. 2003 Mar;33 Suppl:245-54
references: 12610534
references: Nat Neurosci. 2010 Sep;13(9):1120-7
references: 20711185
references: J Neurosci. 2012 Nov 28;32(48):17454-64
references: 23197736
references: Neuron. 2009 May 14;62(3):335-48
references: 19447090
references: J Exp Med. 2010 Aug 30;207(9):1843-51
references: 20643829
references: Nat Struct Mol Biol. 2012 Nov;19(11):1068-75
references: 23132386
references: Sci Transl Med. 2011 Nov 2;3(107):107ra109
references: 22049069
references: Neuron. 2008 Dec 26;60(6):961-74
references: 19109904
references: Nature. 2005 Jun 16;435(7044):903-10
references: 15959507
references: J Neurosci. 2008 Jul 16;28(29):7344-9
references: 18632938
references: Cell. 2008 Jun 27;133(7):1145-8
references: 18585349
references: Science. 2011 Sep 2;333(6047):1300-3
references: 21778364
references: Nat Neurosci. 2013 Jan;16(1):42-7
references: 23242310
references: Neuropsychopharmacology. 2009 Jun;34(7):1710-20
references: 19158668
references: Annu Rev Biochem. 2005;74:481-514
references: 15952895