title: Serum human chorionic gonadotropin levels on the day before oocyte retrieval do not correlate with oocyte maturity.
abstract: OBJECTIVE
  To evaluate the correlation of preretrieval quantitative serum hCG level with oocyte maturity.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Military assisted reproductive technology (ART) program.
  
  
  METHODS
  Fresh autologous ART cycles.
  
  
  METHODS
  Serum hCG level the day before oocyte retrieval.
  
  
  METHODS
  Linear regression was used to correlate serum hCG levels and oocyte maturity rates. Normal oocyte maturity was defined as ≥75% and the Wilcoxon rank sum test was used to compare serum hCG levels in patients with normal and low oocyte maturity. Threshold analysis was performed to determine hCG levels that could predict oocyte maturity.
  
  
  RESULTS
  A total of 468 ART cycles were analyzed. Serum hCG level was not correlated with hCG dose; however, it was negatively correlated with body mass index (BMI). Serum hCG levels did not differ between patients with oocyte maturity of <75% and ≥75%. Serum hCG levels did not correlate with oocyte maturity rates. Receiver operator characteristic and less than efficiency curves failed to demonstrate thresholds at which hCG could predict oocyte maturity.
  
  
  CONCLUSIONS
  Serum hCG levels were not correlated with oocyte maturity. Although a positive hCG was reassuring that mature oocytes would be retrieved for most patients, the specific value was not helpful.
authors: Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1109, USA. gary.levy@nih.gov
authors: Gary
authors: G
authors: Levy
authors: Micah J
authors: MJ
authors: Hill
authors: Christina
authors: C
authors: Ramirez
authors: Torrie
authors: T
authors: Plowden
authors: Justin
authors: J
authors: Pilgrim
authors: Robin S
authors: RS
authors: Howard
authors: James H
authors: JH
authors: Segars
authors: John
authors: J
authors: Csokmay
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood* / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D054315:Oocyte Retrieval / Q000379:methods*; D009865:Oocytes / Q000254:growth & development* / Q000378:metabolism*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D015415:Biomarkers; D006063:Chorionic Gonadotropin
references: Fertil Steril. 2001 Apr;75(4):700-4
references: 11287022
references: Reprod Biol Endocrinol. 2011 Jun 21;9:82
references: 21693025
references: Fertil Steril. 2001 Aug;76(2):397-9
references: 11476796
references: J In Vitro Fert Embryo Transf. 1987 Jun;4(3):168-72
references: 3611925
references: Fertil Steril. 2012 Sep;98(3):671-4
references: 22769734
references: J Clin Endocrinol Metab. 1984 Jul;59(1):178-80
references: 6427270
references: Hum Reprod. 2002 Jun;17(6):1604-9
references: 12042285
references: Fertil Steril. 2009 Jan;91(1):110-4
references: 18249365
references: Hum Reprod. 2003 Nov;18(11):2294-7
references: 14585876
references: Yonsei Med J. 2012 Jan;53(1):181-5
references: 22187250
references: J Assist Reprod Genet. 2012 Aug;29(8):803-10
references: 22644633
references: Clin Exp Reprod Med. 2011 Dec;38(4):234-7
references: 22384448
references: Hum Reprod Update. 2009 Jan-Feb;15(1):5-12
references: 19091754
references: Fertil Steril. 1993 Sep;60(3):418-22
references: 8375519
references: Fertil Steril. 1991 Aug;56(2):225-9
references: 1712735
references: Reprod Biomed Online. 2012 Sep;25(3):284-91
references: 22796230