title: Myeloperoxidase and risk of recurrence of atrial fibrillation after catheter ablation.
abstract: BACKGROUND
  Myeloperoxidase (MPO) has been associated with the development of atrial fibrillation (AF), but its impact on the recurrence of AF after catheter ablation has not been explored. This study investigated the effect of plasma MPO on recurrence after catheter ablation of paroxysmal AF.
  
  
  RESULTS
  Two hundred eighty-eight consecutive patients with paroxysmal AF and who underwent circumferential pulmonary vein isolation were prospectively enrolled. After a mean ± SD follow-up of 516 ± 204 (91-910) days, the recurrence rates were 16.9%, 25.7%, 29.7%, and 38.0% from the lowest MPO quartile to the highest MPO quartile, respectively (P = 0.023). After adjustment for age, sex, left atrial diameter, high-sensitivity C-reactive protein, and pulmonary vein isolation, there was an increased risk of recurrence in the subjects with the highest MPO quartile compared with those with the lowest quartile (hazard ratio, 3.18; 95% confidence interval, 2.12-5.23; P = 0.024). As a continuous variable, MPO was also an independent predictor of recurrence (hazard ratio, 2.12; 95% confidence interval, 1.71-3.27; P = 0.032).
  
  
  CONCLUSIONS
  Patients with high MPO levels were at an increased risk of AF recurrence after catheter ablation.
authors: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors: Shuai-bing
authors: SB
authors: Li
authors: Fan
authors: F
authors: Yang
authors: Li
authors: L
authors: Jing
authors: Juan
authors: J
authors: Ma
authors: Ya-dan
authors: YD
authors: Jia
authors: Shao-ying
authors: SY
authors: Dong
authors: Wei-feng
authors: WF
authors: Zheng
authors: Luo-sha
authors: LS
authors: Zhao
mesh_terms: D001281:Atrial Fibrillation / Q000201:enzymology* / Q000453:epidemiology / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects* / Q000379:methods; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*; D011183:Postoperative Complications; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors
chemical_list: D009195:Peroxidase