title: Primary progressive aphasia with parkinsonism.
abstract: A 65-year-old man presented with word-finding difficulty and gait disturbance. His speech was nonfluent with word retrieval impairment and difficulties with sentence repetition. Other cognitive domains were intact initially. He developed asymmetrical bradykinesia, rigidity and a rest tremor. Over the following 8 years, his speech production impairment slowly deteriorated with the development of a motor speech disorder, anomia, impaired repetition of single words as well as sentences, and impaired comprehension of initially sentences then single words. His parkinsonian syndrome also deteriorated with limited response to levodopa. Serial brain MRI revealed progressive asymmetric perisylvian atrophy. He died after a disease duration of 12 years. The clinical syndrome is discussed by an expert, the pathology is described, and important clinical points from the case are highlighted.
authors: Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK.
authors: Karen M
authors: KM
authors: Doherty
authors: Jonathan D
authors: JD
authors: Rohrer
authors: Andrew J
authors: AJ
authors: Lees
authors: Janice L
authors: JL
authors: Holton
authors: Jason
authors: J
authors: Warren
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism; D018888:Aphasia, Primary Progressive / Q000209:etiology*; D001921:Brain / Q000473:pathology; D020233:Gait Disorders, Neurologic / Q000209:etiology; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D020734:Parkinsonian Disorders / Q000150:complications* / Q000473:pathology; D014956:Writing; D051844:alpha-Synuclein / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D051844:alpha-Synuclein; D016875:tau Proteins
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