title: Effects of curcumin on the gastric emptying of albino rats.
abstract: Curcumin (diferuloylmethane), a polyphenol, is an active principle of the perennial herb Curcuma longa commonly known as turmeric. Turmeric (CURCUMA LONGA L.) is a medicinal plant extensively used in Ayurveda, Unani, and Siddha medicine as a home remedy for various diseases including biliary diseases, cough, hepatic diseases, wound healing. However studies on the effect of curcumin on the gastric emptying are nearly nonexistent. It is hypothesized that curcumin may have an effect on gastric emptying. For this reason the present study was aimed to study the effect of curcumin on gastric emptying. Rats were divided into 5 groups (Group I - Group V), based on the time interval between administration of curcumin/vehicular fluid to administration of barium sulphate (Group I - 1 hr, Group II - 8 hrs, Group III - 16 hrs, Group IV - 24 hrs, Group V - 48 hrs). Each group was further divided into two subgroups, Group A (control) and Group B (experimental), containing 6 rats each. Rats in experimental group were administered curcumin intragastrically, in the dose of 1 gm/kg body weight, suspended in normal saline (0.9% NaCl). The controls were given vehicular fluid intragastrically, in volume equal to the experimental animals. It was observed that there was a decrease in the gastric emptying in all the experimental groups.
authors: Department of Physiology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun - 248 140. purwar_200l@yahoo.co.uk
authors: Brijesh
authors: B
authors: Purwar
authors: Abha
authors: A
authors: Shrivastava
authors: Neetu
authors: N
authors: Arora
authors: Anil
authors: A
authors: Kumar
authors: Yogesh
authors: Y
authors: Saxena
mesh_terms: D000818:Animals; D003474:Curcumin / Q000494:pharmacology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003474:Curcumin