title: The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles.
abstract: The direct measurement of mitochondrial [Ca(2+)] with highly specific probes demonstrated that major swings in organellar [Ca(2+)] parallel the changes occurring in the cytosol and regulate processes as diverse as aerobic metabolism and cell death by necrosis and apoptosis. Despite great biological relevance, insight was limited by the complete lack of molecular understanding. The situation has changed, and new perspectives have emerged following the very recent identification of the mitochondrial Ca(2+) uniporter, the channel allowing rapid Ca(2+) accumulation across the inner mitochondrial membrane.
authors: Department of Biomedical Sciences, University of Padua and the Institute of Neuroscience, Consiglio Nazionale delle Ricerche, 35131 Padua, Italy.
authors: Maria
authors: M
authors: Patron
authors: Anna
authors: A
authors: Raffaello
authors: Veronica
authors: V
authors: Granatiero
authors: Anna
authors: A
authors: Tosatto
authors: Giulia
authors: G
authors: Merli
authors: Diego
authors: D
authors: De Stefani
authors: Lauren
authors: L
authors: Wright
authors: Giorgia
authors: G
authors: Pallafacchina
authors: Anna
authors: A
authors: Terrin
authors: Cristina
authors: C
authors: Mammucari
authors: Rosario
authors: R
authors: Rizzuto
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism*; D009336:Necrosis
chemical_list: D015220:Calcium Channels; C034703:mitochondrial calcium uniporter; D002118:Calcium
references: Nature. 1995 Oct 5;377(6548):438-41
references: 7566122
references: Nat Rev Mol Cell Biol. 2012 Sep;13(9):566-78
references: 22850819
references: J Biol Chem. 2011 Sep 16;286(37):32533-41
references: 21775425
references: Science. 1993 Oct 29;262(5134):744-7
references: 8235595
references: Science. 2003 Apr 4;300(5616):135-9
references: 12624178
references: J Physiol. 2000 Nov 15;529 Pt 1:23-36
references: 11080248
references: J Mol Cell Cardiol. 2009 Jun;46(6):775-80
references: 19303419
references: Nature. 2008 Dec 4;456(7222):605-10
references: 19052620
references: Nature. 2004 Jan 22;427(6972):360-4
references: 14737170
references: J Biol Chem. 1962 Aug;237:2670-7
references: 13925019
references: Biochemistry. 1984 Apr 10;23(8):1645-51
references: 6202317
references: Physiol Rev. 2005 Apr;85(2):757-810
references: 15788710
references: Cell. 2008 Jul 11;134(1):112-23
references: 18614015
references: Nature. 1998 Apr 30;392(6679):933-6
references: 9582075
references: Biochem J. 1987 Sep 1;246(2):271-7
references: 3689311
references: Nature. 1976 Nov 11;264(5582):185-6
references: 995204
references: Neuroscience. 2006 Sep 29;142(1):97-105
references: 16860487
references: Cell Calcium. 2008 Mar;43(3):296-306
references: 17764739
references: Trends Cell Biol. 2009 Feb;19(2):81-8
references: 19144519
references: Nature. 1983 Nov 3-9;306(5938):67-9
references: 6605482
references: Biochem Biophys Res Commun. 1963 Mar 25;10:444-8
references: 13929376
references: Trends Parasitol. 2012 Jan;28(1):31-7
references: 22088944
references: Nature. 2010 Sep 16;467(7313):291-6
references: 20693986
references: Nature. 2009 May 28;459(7246):596-600
references: 19387438
references: J Cell Biol. 2001 Dec 10;155(6):1003-15
references: 11739410
references: Novartis Found Symp. 2001;239:52-64; discussion 64-7, 150-9
references: 11529316
references: J Cardiovasc Pharmacol. 1993 Apr;21(4):595-9
references: 7681905
references: Nat Cell Biol. 2000 Feb;2(2):57-61
references: 10655583
references: Proc Natl Acad Sci U S A. 2000 May 23;97(11):5723-8
references: 10823933
references: Nature. 1992 Jul 23;358(6384):325-7
references: 1322496
references: FEBS Lett. 1979 Aug 15;104(2):347-51
references: 477997
references: Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17404-9
references: 15585581
references: Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3197-202
references: 11248055
references: Cell Calcium. 2011 Sep;50(3):222-33
references: 21601280
references: Nature. 2011 Jun 19;476(7360):336-40
references: 21685888
references: J Physiol. 1883 Aug;4(2-3):222-5
references: 16991350
references: Circulation. 2009 May 12;119(18):2435-43
references: 19398664
references: Mol Cell. 2010 Jul 9;39(1):121-32
references: 20603080
references: Science. 1998 Jun 12;280(5370):1763-6
references: 9624056
references: Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):436-41
references: 20018762
references: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9893-8
references: 8790427
references: Physiol Rev. 1999 Oct;79(4):1127-55
references: 10508231
references: J Biol Chem. 2003 Apr 25;278(17):15153-61
references: 12586823
references: J Gen Physiol. 1967 Aug;50(7):1849-64
references: 6050970
references: Science. 2009 Oct 2;326(5949):144-7
references: 19797662
references: Physiol Rev. 2004 Jan;84(1):277-359
references: 14715917
references: EMBO J. 1999 Sep 15;18(18):4999-5008
references: 10487752
references: J Physiol. 1998 May 15;509 ( Pt 1):59-65
references: 9547381
references: Hum Mol Genet. 2008 Jan 15;17(2):201-14
references: 17925330
references: J Biol Chem. 1985 Mar 25;260(6):3440-50
references: 3838314
references: J Biol Chem. 2000 May 19;275(20):15305-13
references: 10809765
references: Cell. 2010 Jul 23;142(2):270-83
references: 20655468
references: Cell. 1995 Aug 11;82(3):415-24
references: 7634331
references: Biochim Biophys Acta. 1970 Apr 7;205(1):18-26
references: 4245343
references: Nat Cell Biol. 2008 Nov;10(11):1235-7; author reply 1237-40
references: 18978830
references: Semin Cell Biol. 1990 Aug;1(4):311-21
references: 2103516
references: Physiol Rev. 2006 Jan;86(1):369-408
references: 16371601
references: Mol Cell. 2004 Oct 8;16(1):59-68
references: 15469822
references: Physiol Rev. 1994 Jul;74(3):595-636
references: 8036248
references: Proc Natl Acad Sci U S A. 1961 Nov 15;47:1744-50
references: 13885269
references: Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2135-40
references: 10051607
references: Nature. 1982 Jan 7;295(5844):68-71
references: 6799829
references: EMBO J. 2002 Dec 16;21(24):6744-54
references: 12485995
references: EMBO J. 2001 Jun 1;20(11):2690-701
references: 11387204
references: J Physiol. 2008 Jul 1;586(13):3267-85
references: 18467367
references: J Bioenerg Biomembr. 1994 Oct;26(5):495-508
references: 7896765
references: J Cell Biol. 1997 May 5;137(3):633-48
references: 9151670
references: Biochemistry. 1969 Jun;8(6):2481-6
references: 4240515
references: Nat Rev Mol Cell Biol. 2003 Jul;4(7):552-65
references: 12838338
references: Physiol Rev. 1990 Apr;70(2):391-425
references: 2157230
references: Nature. 1967 Jan 14;213(5072):137-9
references: 4291593
references: Nat Cell Biol. 2007 Apr;9(4):445-452
references: 17351641
references: Nature. 2011 Jun 19;476(7360):341-5
references: 21685886
references: J Mol Cell Cardiol. 1974 Aug;6(4):361-71
references: 4855051
references: J Cell Biol. 2000 Mar 6;148(5):857-62
references: 10704437
references: J Cell Biol. 2002 Nov 25;159(4):613-24
references: 12438411
references: Science. 1999 Nov 26;286(5445):1700-5
references: 10576729
references: EMBO J. 1998 Sep 15;17(18):5298-308
references: 9736609
references: J Biol Chem. 2001 Jun 15;276(24):21482-8
references: 11297554
references: Biochem J. 1985 Jul 1;229(1):161-6
references: 3929768
references: Biofactors. 1998;8(3-4):225-8
references: 9914823
references: J Neurosci. 1999 Aug 1;19(15):6372-84
references: 10414966
references: EMBO J. 1999 Jan 4;18(1):96-108
references: 9878054
references: J Biol Chem. 1980 Oct 10;255(19):9009-12
references: 7410406
references: Mol Cell. 2010 Apr 23;38(2):280-90
references: 20417605
references: J Biol Chem. 2011 Jun 17;286(24):21324-9
references: 21524998
references: Nat Rev Mol Cell Biol. 2003 Jul;4(7):579-86
references: 12838340
references: Nat Med. 1999 Aug;5(8):951-4
references: 10426322