title: Asthma and lung structure on computed tomography: the Multi-Ethnic Study of Atherosclerosis Lung Study.
abstract: BACKGROUND
  The potential consequences of asthma in childhood and young adulthood on lung structure in older adults have not been studied in a large, population-based cohort.
  
  
  OBJECTIVE
  The authors hypothesized that a history of asthma onset in childhood (age 18 years or before) or young adulthood (age 19-45 years) was associated with altered lung structure on computed tomography in later life.
  
  
  METHODS
  The Multi-Ethnic Study of Atherosclerosis Lung Study recruited 3965 participants and assessed asthma history by using standardized questionnaires, guideline-based spirometry, and segmental airway dimensions and percentage of low attenuation area (%LAA) on computed tomographic scans.
  
  
  RESULTS
  Asthma with onset in childhood and young adulthood was associated with large decrements in FEV(1) among participants with a mean age of 66 years (-365 mL and -343 mL, respectively; P < .001). Asthma with onset in childhood and young adulthood was associated with increased mean airway wall thickness standardized to an internal perimeter of 10 mm (0.1 mm, P < .001 for both), predominantly from narrower segmental airway lumens (-0.39 mm and -0.34 mm, respectively; P < .001). Asthma with onset in childhood and young adulthood also was associated with a greater %LAA (1.69% and 4.30%, respectively; P < .001). Findings were similar among never smokers, except that differential %LAA in childhood-onset asthma were not seen in them.
  
  
  CONCLUSIONS
  Asthma with onset in childhood or young adulthood was associated with reduced lung function, narrower airways, and among asthmatic patients who smoked, greater %LAA in later life.
authors: Columbia University, New York, NY 10032, USA.
authors: Kathleen M
authors: KM
authors: Donohue
authors: Eric A
authors: EA
authors: Hoffman
authors: Heather
authors: H
authors: Baumhauer
authors: Junfeng
authors: J
authors: Guo
authors: Firas S
authors: FS
authors: Ahmed
authors: Gina S
authors: GS
authors: Lovasi
authors: David R
authors: DR
authors: Jacobs
authors: Paul
authors: P
authors: Enright
authors: R Graham
authors: RG
authors: Barr
mesh_terms: D000367:Age Factors; D000368:Aged; D001249:Asthma / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000473:pathology*; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000473:pathology*; D015331:Cohort Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests / Q000379:methods; D012907:Smoking / Q000473:pathology; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed / Q000379:methods
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