title: Revascularization: a treatment for permanent teeth with necrotic pulp and incomplete root development.
abstract: BACKGROUND
  Endodontic treatment of immature permanent teeth with necrotic pulp, with or without apical pathosis, poses several clinical challenges. There is a risk of inducing a dentin wall fracture or extending gutta-percha into the periapical tissue during compaction of the root canal filling. Although the use of calcium hydroxide apexification techniques or the placement of mineral trioxide aggregate as an apical stop has the potential to minimize apical extrusion of filling material, they do little in adding strength to the dentin walls. It is a well-established fact that in reimplanted avulsed immature teeth, revascularization of the pulp followed by continued root development can occur under ideal circumstances. At one time it was believed that revascularization was not possible in immature permanent teeth that were infected.
  
  
  METHODS
  An in-depth search of the literature was undertaken to review articles concerned with regenerative procedures and revascularization and to glean recommendations regarding the indications, preferred medications, and methods of treatment currently practiced.
  
  
  RESULTS
  Disinfection of the root canal and stimulation of residual stem cells can induce formation of new hard tissue on the existing dentin wall and continued root development.
  
  
  CONCLUSIONS
  Although the outcome of revascularization procedures remains somewhat unpredictable and the clinical management of these teeth is challenging, when successful, they are an improvement to treatment protocols that leave the roots short and the walls of the root canal thin and prone to fracture. They also leave the door open to other methods of treatment in addition to extraction, when they fail to achieve the desired result.
authors: Endodontics and Dental Traumatology Department, Graduate School of Dentistry, Rambam Health Care Campus, Haifa, Israel. dr.wigler@gmail.com
authors: Ronald
authors: R
authors: Wigler
authors: Arieh Y
authors: AY
authors: Kaufman
authors: Shaul
authors: S
authors: Lin
authors: Nelly
authors: N
authors: Steinbock
authors: Hagai
authors: H
authors: Hazan-Molina
authors: Calvin D
authors: CD
authors: Torneck
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D056624:Apexification; D017610:Calcium Compounds / Q000627:therapeutic use; D019551:Dental Disinfectants / Q000627:therapeutic use; D003782:Dental Pulp / Q000098:blood supply*; D003790:Dental Pulp Necrosis / Q000188:drug therapy / Q000628:therapy*; D003804:Dentin / Q000502:physiology; D019229:Dentition, Permanent; D004338:Drug Combinations; D006801:Humans; D018919:Neovascularization, Physiologic; D010087:Oxides / Q000627:therapeutic use; D012388:Root Canal Irrigants / Q000627:therapeutic use; D017640:Silicates / Q000627:therapeutic use; D019227:Tooth Apex / Q000098:blood supply / Q000254:growth & development*
chemical_list: D017607:Aluminum Compounds; D000900:Anti-Bacterial Agents; D017610:Calcium Compounds; D019551:Dental Disinfectants; D004338:Drug Combinations; D010087:Oxides; D012388:Root Canal Irrigants; D017640:Silicates; C086631:mineral trioxide aggregate