title: Is Overweight a Risk of Early Atherosclerosis in Childhood?
abstract: We measured brachial artery flow-mediated dilatation (FMD) and common carotid intima-media thickness (cIMT) in overweight (n = 67) and normal weight children (n = 115, controls). Age at examination ranged from 72 to 182 months (mean 123 ± 27). Compared to controls, the overweight children had increased weight, waist and hip circumference, systolic and diastolic blood pressures (allP< .001), right and left mean cIMT (mm; 0.58 [0.42-0.68] vs 0.44 [0.3-0.64],P< .001 and 0.56 [0.32-0.70] vs 0.44 [0.3-0.60],P< .001), respectively, and decreased FMD (%; 6.25 [3.33-19.05] vs 7.69 [3.45-16],P< .001). The cIMT and FMD were closely related to the serum insulin concentrations. Age, waist circumferences, and serum triglycerides were independent predictive risk factors for increased cIMT, and fasting glucose and BMI were independent predictive variables for decreased FMD. Overweight children are also potentially at risk of early atherosclerosis as much as obese children.
authors: Department of Cardiology, Faculty of Medicine, Namık Kemal University Medical School, Turkey.
authors: Seref
authors: S
authors: Alpsoy
authors: Department of Cardiology, Faculty of Medicine, Namık Kemal University Medical School, Turkey.
authors: Aydın
authors: A
authors: Akyuz
authors: Department of Cardiology, Faculty of Medicine, Namık Kemal University Medical School, Turkey.
authors: Dursun Cayan
authors: DC
authors: Akkoyun
authors: Department of Pediatrics, Faculty of Medicine, Namık Kemal University Medical School, Turkey.
authors: Burcin
authors: B
authors: Nalbantoglu
authors: Department of Biostatistics, Faculty of Medicine, Namık Kemal University Medical School, Turkey.
authors: Birol
authors: B
authors: Topcu
authors: Department of Biochemistry, Faculty of Medicine, Namık Kemal University Medical School, Turkey.
authors: Feti
authors: F
authors: Tulubas
authors: Department of Pediatrics, Faculty of Medicine, Namık Kemal University Medical School, Turkey.
authors: Muhammet
authors: M
authors: Demirkol
authors: Department of Pediatrics, Faculty of Medicine, Namık Kemal University Medical School, Turkey.
authors: Mustafa Metin
authors: MM
authors: Donma
mesh_terms: D000293:Adolescent; D000367:Age Factors; D050197:Atherosclerosis / Q000453:epidemiology* / Q000209:etiology*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D063766:Pediatric Obesity / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D018570:Risk Assessment; D012307:Risk Factors
keywords: carotid intima-media thickness; childhood; flow-mediated dilatation; overweight; peripheral arterial disease