title: Hepatitis B reactivation related to everolimus.
abstract: Reactivation of hepatitis B virus (HBV) during chemotherapy is a well known complication in patients with chronic hepatitis B and cancer. The clinical manifestations range from subclinical elevation of liver enzymes to severe, potentially fatal fulminant hepatitis. Reactivation can occur in a patient with previous inactive HBV infection; either an inactive carrier or a patient with resolved hepatitis. Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved in renal cell carcinoma, neuroendocrine tumours and breast cancer. mTOR inhibitors are a new generation of drugs for targeted treatment; therefore, little about their side effects is known. Here, we report a patient with renal cell carcinoma who experienced a flare of hepatitis B infection during treatment with everolimus. Clinicians should be aware of HBV reactivation in patients who are undergoing treatment with everolimus, and screening for hepatitis B infection and prophylactic antiviral treatment should be considered.
authors: Sema Sezgin Göksu, Şerife Bilal, Hasan Şenol Coşkun, Faculty of Medicine, Department of Medical Oncology, Akdeniz Univercity, 07058 Antalya, Turkey.
authors: Sema
authors: S
authors: Sezgin Göksu
authors: Serife
authors: S
authors: Bilal
authors: Hasan Şenol
authors: HŞ
authors: Coşkun
keywords: Everolimus; Hepatitis B; Immunosuppressive treatment; Mammalian target of rapamycin inhibitors; Renal cell carcinoma; Virus reactivation
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