title: Estimation of dietary intake of bis(2-ethylhexyl)phthalate (DEHP) by consumption of food in the German population.
abstract: In the study presented here, we evaluated the exposure of the German population aged 14-80 years to bis(2-ethylhexyl)phthalate (DEHP) from consumption of food by means of deterministic and probabilistic estimations. The study was performed on the basis of an extensive review of literature from around the world reporting measured data on DEHP in food, as well as official German food control data. Only data from individual measurements were considered and used for fitting of distributions. A wide range of concentrations in non-representative samples are reported in the literature. On the basis of the available DEHP concentration data, 37 food categories were characterized which covered all major food classes. Food consumption data were taken from the diet history interviews of the German National Nutrition Survey II (Nationale Verzehrsstudie II) which was performed in 2005/2006 in a representative study population of 15,371 and is the most recent data source of this kind in Germany. Average DEHP intake was estimated deterministically using data on measured concentrations in food (medians and means) and food consumption (means). A total dietary exposure to DEHP of 3.6 (median based) and 9.3μg/kg of BW per day (based on mean values) was estimated deterministically. In addition, distributions of both concentrations and consumption figures were fitted using the @RISK best fit tool for further probabilistic estimations. This approach resulted in estimates within the same range: the estimated median DEHP intake in the whole population (both non-consumers and consumers of the foods considered) was 10.2, the arithmetic mean 14.0 and the 95th percentile 28.6μg/kg of BW per day. The respective estimates for consumers only were 12.4, 18.7 and 36.5μg/kg of BW per day. These results demonstrate that the probabilistic approach is able to estimate broader ranges of exposure even when using data representing an average intake. Moreover, it reflects the uncertainties of the estimation due to insufficient analytical data on concentrations of DEHP in food.
authors: Federal Institute for Risk Assessment (Bundesinstitut für Risikobewertung), Max-Dohrn-Str. 8-10, D-10589 Berlin, Germany. gerhard.heinemeyer@bfr.bund.de
authors: Gerhard
authors: G
authors: Heinemeyer
authors: Christine
authors: C
authors: Sommerfeld
authors: Andrea
authors: A
authors: Springer
authors: Astrid
authors: A
authors: Heiland
authors: Oliver
authors: O
authors: Lindtner
authors: Matthias
authors: M
authors: Greiner
authors: Thorsten
authors: T
authors: Heuer
authors: Carolin
authors: C
authors: Krems
authors: André
authors: A
authors: Conrad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004032:Diet; D004051:Diethylhexyl Phthalate / Q000032:analysis*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000032:analysis*; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009010:Monte Carlo Method; D009749:Nutrition Surveys; D010968:Plasticizers / Q000032:analysis*; D018570:Risk Assessment; D035501:Uncertainty; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D010968:Plasticizers; D004051:Diethylhexyl Phthalate