title: Intravenous immunoglobulin-induced hemolytic anemia in a patient with juvenile dermatomyositis.
abstract: We report a case of hemolytic anemia in a female patient with juvenile dermatomyositis. Rapidly progressive hemolysis developed during prednisone and azathioprine combination therapy 4 days after completing intravenous immunoglobulin (IVIG) treatment. While the blood smear revealed spherocytes and polychromasia, direct and indirect antiglobulin tests were negative. In the following case report, we propose probable IVIG-induced hemolytic anemia and explore the pathomechanisms that may account for hemolysis.
authors: University of South Carolina School of medicine, Columbia, SC, USA. mclemenz@gmail.com
authors: Melanie R
authors: MR
authors: Clemenz
authors: Joseph Wilson
authors: JW
authors: McGowan Iv
authors: Marshall J
authors: MJ
authors: Shuler
authors: Annette W
authors: AW
authors: Lynn
mesh_terms: D000743:Anemia, Hemolytic / Q000139:chemically induced*; D001706:Biopsy; D002648:Child; D003882:Dermatomyositis / Q000150:complications* / Q000188:drug therapy; D004906:Erythrocyte Count; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects* / Q000627:therapeutic use; D059352:Musculoskeletal Pain / Q000150:complications; D012867:Skin / Q000473:pathology
chemical_list: D006242:Haptoglobins; D006454:Hemoglobins; D016756:Immunoglobulins, Intravenous