title: Effect of positive end-expiratory pressure after porcine unilateral left lung transplant.
abstract: OBJECTIVE
  To evaluate the effects of 2 different levels of positive end-expiratory pressure on pigs who had unilateral lung transplants.
  
  
  METHODS
  A left lung transplant was performed in 12 pigs. The animals were randomized into 2 groups based on positive end-expiratory pressure: group 1 (5 cm H(2)O) and group 2 (10 cm H(2)O). Hemodynamics, gas exchange, and respiratory mechanics were measured before and after surgery. Cytokines, oxidative stress, and histologic scores were assessed in the lung tissue of each pig.
  
  
  RESULTS
  Pigs in group 2 exhibited a significantly higher mean heart rate (P = .006), static compliance (P = .001), lower mean arterial pressure (P = .003), and airway resistance (P = .001) than did pigs in group 1. There were no postoperative differences between the groups in concentrations of thiobarbituric acid reactive substances, superoxide dismutase, and interleukin 8. At the end of the observation period, pigs in group 2 had higher levels of thiobarbituric acid reactive substances (P = .001) and interleukin 8 (P = .05), and pigs in group 1 had higher levels of superoxide dismutase (P = .05) than they did at baseline.
  
  
  CONCLUSIONS
  After unilateral lung transplant, higher positive end-expiratory pressure was associated with improved respiratory mechanics, a negative effect on hemodynamics, a stronger inflammatory response, and increased production of reactive oxygen species, but no effect on gas exchange.
authors: Hospital Ernesto Dornelles, Porto Alegre, Brazil.
authors: Gabriel Ribeiro
authors: GR
authors: Madke
authors: Luiz Alberto
authors: LA
authors: Forgiarini
authors: Gustavo
authors: G
authors: Grün
authors: Eduardo
authors: E
authors: Fontena
authors: Raoni Bins
authors: RB
authors: Pereira
authors: Mikael Marcelo
authors: MM
authors: de Moraes
authors: Rodrigo
authors: R
authors: Mariano
authors: Paulo Francisco Guerreiro
authors: PF
authors: Cardoso
authors: Elaine Aparecida
authors: EA
authors: Felix
authors: Cristiano Feijó
authors: CF
authors: Andrade
mesh_terms: D000818:Animals; D006439:Hemodynamics / Q000502:physiology*; D016209:Interleukin-8 / Q000378:metabolism; D008168:Lung / Q000378:metabolism / Q000473:pathology; D016040:Lung Transplantation / Q000473:pathology / Q000502:physiology*; D023421:Models, Animal; D011175:Positive-Pressure Respiration; D017382:Reactive Oxygen Species / Q000378:metabolism; D015656:Respiratory Mechanics / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013552:Swine; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D016209:Interleukin-8; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase