title: Next-generation medicine: combining BCR-ABL and Hedgehog-targeted therapies.
abstract: Disease relapse remains a major cause of death in patients with BCR-ABL-positive leukemia despite advances in treatment with kinase inhibitors. Significant efforts are underway to target pathways that maintain leukemia stem cells. Targeting these pathways holds promise for definitive leukemia eradication or improvement of the effectiveness of currently available therapies.
authors: Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland 97239, Oregon, USA.
authors: Kim-Hien T
authors: KH
authors: Dao
authors: Jeffrey W
authors: JW
authors: Tyner
mesh_terms: D000813:Anilides / Q000008:administration & dosage*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D011724:Pyridazines / Q000008:administration & dosage*; D011725:Pyridines / Q000008:administration & dosage*
chemical_list: D000813:Anilides; C538724:HhAntag691; D007093:Imidazoles; D011724:Pyridazines; D011725:Pyridines; C545373:ponatinib
references: Int J Hematol. 2011 Aug;94(2):109-117
references: 21800073
references: Cancer Cell. 2008 Sep 9;14(3):238-49
references: 18772113
references: Cell Stem Cell. 2009 Jun 5;4(6):548-58
references: 19497283
references: Cancer Sci. 2010 Jul;101(7):1577-81
references: 20491777
references: Cell Stem Cell. 2009 Jun 5;4(6):559-67
references: 19497284
references: Hematology Am Soc Hematol Educ Program. 2009;:461-76
references: 20008232
references: Cancer Lett. 2013 Sep 10;338(1):15-22
references: 22906415
references: Leuk Lymphoma. 2013 Feb;54(2):342-52
references: 22762548
references: Clin Cancer Res. 2013 Mar 15;19(6):1422-32
references: 23319824
references: J Exp Clin Cancer Res. 2011 Jan 16;30:8
references: 21235817
references: Exp Cell Res. 2012 Oct 1;318(16):1959-72
references: 22659135
references: Nature. 2009 Apr 9;458(7239):776-9
references: 19169242