title: GABAA receptors predict aversion-related brain responses: an fMRI-PET investigation in healthy humans.
abstract: The perception of aversive stimuli is essential for human survival and depends largely on environmental context. Although aversive brain processing has been shown to involve the sensorimotor cortex, the neural and biochemical mechanisms underlying the interaction between two independent aversive cues are unclear. Based on previous work indicating ventromedial prefrontal cortex (vmPFC) involvement in the mediation of context-dependent emotional effects, we hypothesized a central role for the vmPFC in modulating sensorimotor cortex activity using a GABAergic mechanism during an aversive-aversive stimulus interaction. This approach revealed differential activations within the aversion-related network (eg, sensorimotor cortex, midcingulate, and insula) for the aversive-aversive, when compared with the aversive-neutral, interaction. Individual differences in sensorimotor cortex signal changes during the aversive-aversive interaction were predicted by GABAA receptors in both vmPFC and sensorimotor cortex. Together, these results demonstrate the central role of GABA in mediating context-dependent effects in aversion-related processing.
authors: Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, Royal Ottawa Health Care Group, University of Ottawa, Ottawa, ON, Canada. david.hayes@theroyal.ca
authors: Dave J
authors: DJ
authors: Hayes
authors: Niall W
authors: NW
authors: Duncan
authors: Christine
authors: C
authors: Wiebking
authors: Karin
authors: K
authors: Pietruska
authors: Pengmin
authors: P
authors: Qin
authors: Stefan
authors: S
authors: Lang
authors: Jean
authors: J
authors: Gagnon
authors: Paul Gravel
authors: PG
authors: Bing
authors: Jeroen
authors: J
authors: Verhaeghe
authors: Alexey P
authors: AP
authors: Kostikov
authors: Ralf
authors: R
authors: Schirrmacher
authors: Andrew J
authors: AJ
authors: Reader
authors: Julien
authors: J
authors: Doyon
authors: Pierre
authors: P
authors: Rainville
authors: Georg
authors: G
authors: Northoff
mesh_terms: D000293:Adolescent; D000328:Adult; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D005544:Forecasting; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D011963:Receptors, GABA-A / Q000378:metabolism*; D055815:Young Adult
chemical_list: D011963:Receptors, GABA-A
references: J Neurosci. 2000 Oct 1;20(19):7438-45
references: 11007903
references: Psychosom Med. 2005 Nov-Dec;67(6):957-63
references: 16314601
references: J Neurosci. 2003 Sep 24;23(25):8800-7
references: 14507980
references: Learn Mem. 2010 Nov 01;17(11):591-9
references: 21041382
references: J Neurosci Res. 2005 Feb 1;79(3):383-91
references: 15619231
references: Biol Psychiatry. 2011 Mar 1;69(5):432-41
references: 21146155
references: Neuroimage. 2004;23 Suppl 1:S208-19
references: 15501092
references: Neuroimage. 2006 Jan 1;29(1):106-16
references: 16181793
references: J Neurosci Methods. 2009 Nov 15;184(2):224-34
references: 19686778
references: Hum Brain Mapp. 2011 Dec;32(12):2172-82
references: 21305662
references: Neuropsychologia. 2008 Jan 15;46(1):102-10
references: 17884110
references: J Psychopharmacol. 2011 Dec;25(12):1661-75
references: 21169393
references: Neuroimage. 2010 Jan 1;49(1):843-8
references: 19616105
references: Front Neurosci. 2011 May 20;5:71
references: 21637321
references: Hum Brain Mapp. 2014 Jan;35(1):173-84
references: 22996793
references: Trends Neurosci. 2010 Jun;33(6):277-84
references: 20226543
references: Nat Neurosci. 2012 Jul 01;15(8):1117-9
references: 22751038
references: Behav Brain Res. 2008 Mar 17;188(1):154-67
references: 18067977
references: Neuropharmacology. 2009;56 Suppl 1:122-32
references: 18675281
references: Nat Rev Drug Discov. 2011 Jul 29;10(9):685-97
references: 21799515
references: J Neurosci. 2007 Feb 28;27(9):2349-56
references: 17329432
references: Nat Neurosci. 2012 May;15(5):776-85
references: 22484571
references: Nat Neurosci. 2007 Dec;10(12):1515-7
references: 17982452
references: Arch Gen Psychiatry. 2008 Oct;65(10):1176-84
references: 18838634
references: Trends Cogn Sci. 2009 Nov;13(11):479-87
references: 19782634
references: Hum Brain Mapp. 2007 May;28(5):409-23
references: 17133391
references: Nature. 2010 Nov 11;468(7321):277-82
references: 21068837
references: Neuroimage. 2003 Mar;18(3):740-8
references: 12667851
references: Front Behav Neurosci. 2011 May 23;5:23
references: 21647395
references: Hum Brain Mapp. 2012 Feb;33(2):455-65
references: 21416560
references: Neurobiol Learn Mem. 2010 Nov;94(4):499-508
references: 20833253
references: Neuroimage. 2011 Feb 1;54(3):2237-49
references: 20932917
references: Neuroimage. 2003 Nov;20(3):1540-51
references: 14642466
references: Pharmacol Biochem Behav. 1988 Nov;31(3):523-31
references: 3251236
references: Pain. 2009 Mar;142(1-2):89-93
references: 19167811
references: Neuroimage. 2011 Aug 1;57(3):1221-33
references: 21609772
references: Nature. 1995 Jan 19;373(6511):249-52
references: 7816140
references: Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16188-93
references: 21911384
references: Front Psychol. 2012 Feb 07;3:27
references: 22347207
references: Behav Brain Res. 2010 Mar 5;207(2):249-64
references: 19913058
references: Front Psychol. 2012 May 11;3:145
references: 22593750
references: Front Integr Neurosci. 2011 Oct 03;5:49
references: 22102836
references: J Neurosci. 2011 Mar 30;31(13):4991-9
references: 21451037
references: Trends Cogn Sci. 2012 Mar;16(3):147-56
references: 22310704
references: Pain. 2010 Jun;149(3):453-462
references: 20417032
references: Cereb Cortex. 2013 Aug;23(8):1874-83
references: 22763169
references: Int J Psychophysiol. 2010 Mar;75(3):349-56
references: 20093150
references: Biol Psychiatry. 2011 Jun 1;69(11):1019-25
references: 21276963
references: Front Neurosci. 2011 Sep 09;5:102
references: 21927595
references: Neuropsychopharmacology. 2009 Mar;34(4):932-43
references: 18536699
references: Brain Res. 2006 Jan 12;1068(1):205-12
references: 16364261
references: BMC Neurosci. 2012 Jun 07;13:60
references: 22676259
references: Emotion. 2009 Apr;9(2):271-276
references: 19348539
references: Neuroimage. 2008 Apr 1;40(2):811-817
references: 18203622
references: Neuroimage. 2008 Jun;41(2):260-9
references: 18411060
references: Ann Neurol. 1991 Nov;30(5):663-72
references: 1662476
references: J Neurosci. 2011 Feb 2;31(5):1752-61
references: 21289185
references: Hum Brain Mapp. 2011 Jan;32(1):127-40
references: 21157879
references: J Neurophysiol. 2011 Nov;106(5):2642-52
references: 21880942
references: Exp Brain Res. 2000 Aug;133(4):552-6
references: 10985690
references: Behav Pharmacol. 2008 Sep;19(5-6):582-96
references: 18690113