title: Normocalcemic primary hyperparathyroidism.
abstract: Primary hyperparathyroidism, a common endocrine disorder, is traditionally defined by hypercalcemia and elevated levels of parathyroid hormone (PTH). A newer presentation of primary hyperparathyroidism has been described over the past decade, in which PTH is elevated but serum calcium is consistently normal, in the absence of secondary causes of hyperparathyroidism, such as renal disease or vitamin D deficiency. Recognition of this phenotype of primary hyperparathyroidism, normocalcemic primary hyperparathyroidism, supports a biphasic chronological time course in some individuals in which PTH levels are first elevated but serum calcium is normal, followed by the development of frank hypercalcemia. This review focuses on the available literature regarding this newly described phenotype of primary hyperparathyroidism.
authors: Division of Endocrinology, Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
authors: Natalie E
authors: NE
authors: Cusano
authors: Shonni J
authors: SJ
authors: Silverberg
authors: John P
authors: JP
authors: Bilezikian
mesh_terms: D002118:Calcium / Q000097:blood; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000097:blood; D010641:Phenotype; D014808:Vitamin D Deficiency / Q000150:complications
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium
references: World J Surg. 2012 Apr;36(4):761-6
references: 22286968
references: J Clin Invest. 1973 Jan;52(1):134-42
references: 4682379
references: J Clin Endocrinol Metab. 1989 Mar;68(3):654-60
references: 2918061
references: JAMA. 1969 Nov 17;210(7):1243-5
references: 5394647
references: Am J Kidney Dis. 2003 Oct;42(4 Suppl 3):S1-201
references: 14520607
references: Ann Intern Med. 1993 Mar 1;118(5):337-43
references: 8430979
references: Am J Med. 2004 Dec 1;117(11):861-3
references: 15589491
references: Surgery. 1997 Mar;121(3):287-94
references: 9092129
references: Lancet. 1972 Mar 4;1(7749):503-7
references: 4110019
references: J Clin Endocrinol Metab. 2008 Sep;93(9):3462-70
references: 18544625
references: J Clin Endocrinol Metab. 2006 May;91(5):1748-53
references: 16492695
references: Kidney Int Suppl. 2009 Aug;(113):S1-130
references: 19644521
references: Endocrine. 2012 Oct;42(2):419-22
references: 22327928
references: Arq Bras Endocrinol Metabol. 2010 Mar;54(2):106-9
references: 20485897
references: Surgery. 2004 Dec;136(6):1242-6
references: 15657582
references: J Endocrinol Invest. 2008 Oct;31(10):845-50
references: 19092286
references: Am J Kidney Dis. 1997 Apr;29(4):496-502
references: 9100037
references: J Bone Miner Res. 1999 Apr;14(4):652-7
references: 10234588
references: J Clin Endocrinol Metab. 2007 Aug;92(8):3001-5
references: 17536001
references: J Clin Endocrinol Metab. 2009 Feb;94(2):335-9
references: 19193908
references: J Clin Endocrinol Metab. 2003 Oct;88(10):4641-8
references: 14557434
references: Endocrine. 2012 Dec;42(3):764-6
references: 22573047
references: J Clin Endocrinol Metab. 2012 May;97(5):1501-7
references: 22399521
references: J Clin Endocrinol Metab. 2003 Nov;88(11):5348-52
references: 14602772
references: N Engl J Med. 1986 Jun 5;314(23):1481-5
references: 3754618
references: J Clin Endocrinol Metab. 1988 Dec;67(6):1294-8
references: 3192682
references: J Osteoporos. 2012;2012:128352
references: 22545220
references: Am J Med. 1969 Sep;47(3):384-91
references: 5808655
references: N Engl J Med. 1999 Oct 21;341(17):1249-55
references: 10528034