title: The effects of cigarette smoking on learning and memory performance among people living with HIV/AIDS.
abstract: The purpose of this study was to examine the effects of smoking (past and current) on multiple domains of cognitive functioning in a sample of people living with HIV/AIDS (PLWHA). We hypothesized that among PLWHA, current smokers would demonstrate poorer cognitive functioning when compared to non-smokers, specifically in the cognitive domains of auditory-verbal learning and memory, visuospatial memory, overall cognitive efficiency, executive skills, processing speed, and working memory. Results suggest that in patients being treated for HIV infection, current smoking is negatively associated with learning, memory, and global cognitive functioning. There was also some evidence that cognitive deficits in learning associated with smoking were more pronounced among men compared to women. However, the cause of these effects is not at all clear. In multivariate models, the differences associated with smoking were non-significant when adjusting for education and hepatitis C virus infection. Therefore, smoking may simply reflect a general tendency to more widespread deficits and comorbidities rather than directly impacting cognitive function. Future studies should attempt to examine a priori cognitive factors which contribute to smoking debut and other associated risk factors in order to understand why smoking may be a marker for other risk factors and may ultimately influence neurocognitive functioning critical to daily activities and adherence.
authors: a Behavioral and Social Sciences , Brown University , Providence , RI , USA.
authors: Vaughn E
authors: VE
authors: Bryant
authors: Christopher W
authors: CW
authors: Kahler
authors: Kathryn N
authors: KN
authors: Devlin
authors: Peter M
authors: PM
authors: Monti
authors: Ronald A
authors: RA
authors: Cohen
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000523:psychology; D000328:Adult; D003071:Cognition / Q000187:drug effects*; D005260:Female; D015658:HIV Infections / Q000523:psychology*; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008875:Middle Aged; D009483:Neuropsychological Tests; D012307:Risk Factors; D012494:Sampling Studies; D012907:Smoking / Q000009:adverse effects* / Q000523:psychology*; D014706:Verbal Learning / Q000187:drug effects
references: Am J Clin Nutr. 2008 Apr;87(4):801-9
references: 18400700
references: Am J Public Health. 2003 Jun;93(6):994-8
references: 12773367
references: J Biol Chem. 2012 Jan 27;287(5):3079-86
references: 22084248
references: Psychol Addict Behav. 2012 Dec;26(4):838-49
references: 22642858
references: World J Gastroenterol. 2011 Aug 7;17(29):3369-74
references: 21876628
references: J Abnorm Psychol. 2002 Nov;111(4):670-5
references: 12428781
references: Arch Intern Med. 2008 Jun 9;168(11):1165-73
references: 18541824
references: J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):451-8
references: 9170420
references: Free Radic Biol Med. 1998 Jul 1;25(1):79-86
references: 9655525
references: AIDS Care. 2011 Oct;23(10):1187-207
references: 21939401
references: Chest. 2003 Jun;123(6):1977-82
references: 12796177
references: J Am Coll Cardiol. 2004 May 19;43(10):1731-7
references: 15145091
references: Monaldi Arch Chest Dis. 2001 Dec;56(6):545-54
references: 11980288
references: AIDS Educ Prev. 2009 Jun;21(3 Suppl):65-80
references: 19537955
references: AIDS Educ Prev. 2009 Jun;21(3 Suppl):54-64
references: 19537954
references: J Gen Intern Med. 2005 Dec;20(12):1142-5
references: 16423106
references: Neurology. 2010 Sep 7;75(10):864-73
references: 20702792
references: Sex Transm Infect. 2007 Feb;83(1):41-6
references: 16923740
references: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):374-83
references: 8948377
references: Drug Alcohol Depend. 2012 Apr 1;122(1-2):105-11
references: 21992872
references: Clin Infect Dis. 2000 Sep;31(3):808-12
references: 11017836
references: Neuroepidemiology. 2006;26(2):83-92
references: 16352911
references: J Int Neuropsychol Soc. 2012 Jan;18(1):68-78
references: 22132928
references: Ann Epidemiol. 1996 Sep;6(5):420-30
references: 8915473
references: AIDS. 2011 Mar 13;25(5):561-75
references: 21160410
references: Clin Infect Dis. 2008 Aug 15;47(4):542-53
references: 18627268
references: J Med Virol. 2009 Jul;81(7):1184-8
references: 19475611
references: Nicotine Tob Res. 2004 Feb;6(1):71-7
references: 14982690
references: AIDS Patient Care STDS. 2001 Dec;15(12):615-24
references: 11788076
references: Alcohol. 2007 Nov;41(7):489-501
references: 17923369
references: Ann Behav Med. 2011 Dec;42(3):352-60
references: 21818528