title: Evaluating evolutionary models of stress-induced mutagenesis in bacteria.
abstract: Increased mutation rates under stress allow bacterial populations to adapt rapidly to stressors, including antibiotics. Here we evaluate existing models for the evolution of stress-induced mutagenesis and present a new model arguing that it evolves as a result of a complex interplay between direct selection for increased stress tolerance, second-order selection for increased evolvability and genetic drift. Further progress in our understanding of the evolutionary biology of stress and mutagenesis will require a more detailed understanding both of the patterns of stress encountered by bacteria in nature and of the mutations that are produced under stress.
authors: Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. craig.maclean@zoo.ox.ac.uk
authors: R Craig
authors: RC
authors: MacLean
authors: Clara
authors: C
authors: Torres-Barceló
authors: Richard
authors: R
authors: Moxon
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics; D001419:Bacteria / Q000235:genetics*; D019143:Evolution, Molecular; D040961:Genetic Drift; D008957:Models, Genetic; D016296:Mutagenesis; D059645:Mutation Rate; D010641:Phenotype; D012641:Selection, Genetic; D013312:Stress, Physiological
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