title: Triazole linked lower rim glycosyl appended 1,3-calix[4]arene conjugates: Synthesis, characterization, and their interaction with jacalin.
abstract: Triazole linked lower rim galactosyl and lactosyl appended calix[4]arene conjugates have been synthesized by 1,3 dipolar addition of glycosyl azide and calix[4]arene alkyne. All these conjugates were characterized by (1)H and (13)C NMR, IR and mass spectrometry. Interaction of amino acids with the galactosyl conjugate of calix[4]arene (5) was studied using absorption and (1)H NMR techniques. Absorption studies showed that Trp interacts with triazole ring of 5. This was further confirmed by (1)H NMR study which showed an upfield shift in the triazole proton of 5 upon titrating with Trp. The preliminary studies of interaction of these conjugates with Jacalin were demonstrated by fluorescence and circular dichroism (CD) spectroscopy techniques.
authors: Bioinorganic Laboratory, Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400 076, India.
authors: Jugun Prakash
authors: JP
authors: Chinta
authors: Chebrolu P
authors: CP
authors: Rao
mesh_terms: D006031:Glycosylation; D037121:Plant Lectins / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D037121:Plant Lectins; D014230:Triazoles; C043696:jacalin