title: Ghrelins, obestatin, nesfatin-1 and leptin levels in pregnant women with and without hyperemesis gravidarum.
abstract: OBJECTIVE
  The goal of this study was to compare levels of acyl and des-acyl ghrelin, obestatin, nesfatin-1 and leptin in healthy gravidas to hyperemesis gravidarum (HG) patients.
  
  
  METHODS
  Twenty pregnant women with HG and twenty healthy pregnant women all of similar ages, BMI and all at similar pregnancy development comprised the study cohort. Fasting serum samples were obtained and measured for acyl and des-acyl ghrelin, leptin, obestatin and nesfatin-1.
  
  
  RESULTS
  Nesfatin-1 concentrations in the HG group were higher compared to the control group whereas; leptin concentrations during pregnancy were lower in the HG group as compared to the control group. The two groups did not differ with regard to acyl and des-acyl ghrelin and obestatin.
  
  
  CONCLUSIONS
  This pilot study suggests a possible role of leptin and nesfatin-1, which might be involved in the pathology of the disease.
authors: Department of Obstetrics and Gynecology, Firat University Hospital, 23119 Elazig, Turkey.
authors: Sami
authors: S
authors: Gungor
authors: Bilgin
authors: B
authors: Gurates
authors: Suleyman
authors: S
authors: Aydin
authors: Ibrahim
authors: I
authors: Sahin
authors: Salih Burçin
authors: SB
authors: Kavak
authors: Selahattin
authors: S
authors: Kumru
authors: Husnu
authors: H
authors: Celik
authors: Aziz
authors: A
authors: Aksoy
authors: Musa
authors: M
authors: Yilmaz
authors: Zekiye
authors: Z
authors: Catak
authors: Cihan
authors: C
authors: Citil
authors: Yakup
authors: Y
authors: Baykus
authors: Rulin
authors: R
authors: Deniz
authors: Fethi
authors: F
authors: Karakaya
authors: Nazan
authors: N
authors: Özdemir
mesh_terms: D000328:Adult; D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000097:blood*; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood* / Q000175:diagnosis; D020738:Leptin / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D011247:Pregnancy; D055815:Young Adult
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D054439:Ghrelin; D020738:Leptin; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; C505799:obestatin, human