title: Multiple sclerosis: individualized disease susceptibility and therapy response.
abstract: Multiple sclerosis (MS) is a heterogeneous disease in which diverse genetic, pathological and clinical backgrounds lead to variable therapy response. Accordingly, MS care should be tailored to address disease traits unique to each person. At the core of personalized management is the emergence of new knowledge, enabling optimized treatment and disease-modifying therapies. This overview analyzes the promise of genetic and nongenetic biomarkers in advancing decision-making algorithms to assist diagnosis or in predicting the disease course and therapy response in any given MS patient.
authors: Institute of Microbiology & Immunology, School of Medicine, University of Belgrade, Belgrade, Serbia. pravica@med.bg.ac.rs
authors: Vera
authors: V
authors: Pravica
authors: Milos
authors: M
authors: Markovic
authors: Maja
authors: M
authors: Cupic
authors: Emina
authors: E
authors: Savic
authors: Dusan
authors: D
authors: Popadic
authors: Jelena
authors: J
authors: Drulovic
authors: Marija
authors: M
authors: Mostarica-Stojkovic
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D004198:Disease Susceptibility; D006680:HLA Antigens / Q000378:metabolism; D006801:Humans; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D020641:Polymorphism, Single Nucleotide; D057285:Precision Medicine; D011379:Prognosis
chemical_list: D015415:Biomarkers; D006680:HLA Antigens