title: [Instrumental therapy of drug-resistant hypertension].
abstract: It is well known that hypertension is an independent cardiovascular risk factor. Treatment of hypertension frequently includes administration of three or more drugs. Resistant hypertension is defined when blood pressure remains above target value despite full doses (the patient's maximum tolerated dose) of antihypertensive medication consisting of at least three different classes of drugs including a diuretic. Pharmacological treatment of hypertension is often unsuccessful despite the increasing number of drug combinations. Uncontrolled hypertension, however, increases the cardiovascular risk. Instrumental treatment of resistant hypertension is currently testing two major fields. One is the stimulation of baroreceptors in the carotid sinus and the other is radiofrequency ablation of sympathetic nerve fibers around renal arteries to reduce blood pressure in drug resistant hypertension.
authors: Pest Megyei Flór Ferenc Kórház, Kardiometabolikus Centrum V. Belgyógyászat, Lipidológiai Osztály és Nefrológiai Részleg.
authors: Gábor
authors: G
authors: Simonyi
authors: J Róbert
authors: JR
authors: Bedros
authors: Mihály
authors: M
authors: Medvegy
mesh_terms: D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D002346:Carotid Sinus / Q000503:physiopathology; D017115:Catheter Ablation; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D011311:Pressoreceptors / Q000503:physiopathology; D012077:Renal Artery / Q000294:innervation*; D013562:Sympathectomy
chemical_list: D000959:Antihypertensive Agents