title: The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design.
abstract: OBJECTIVE
  Recognition of the complex, multidimensional relationship between excess adiposity and cancer control outcomes has motivated the scientific community to seek new research models and paradigms.
  
  
  METHODS
  The National Cancer Institute developed an innovative concept to establish a center grant mechanism in nutrition, energetics, and physical activity, referred to as the Transdisciplinary Research on Energetics and Cancer (TREC) Initiative. This paper gives an overview of the 2011-2016 TREC Collaborative Network and the 15 research projects being conducted at the centers.
  
  
  RESULTS
  Four academic institutions were awarded TREC center grants in 2011: Harvard University, University of California San Diego, University of Pennsylvania, and Washington University in St. Louis. The Fred Hutchinson Cancer Research Center is the Coordination Center. The TREC research portfolio includes three animal studies, three cohort studies, four randomized clinical trials, one cross-sectional study, and two modeling studies. Disciplines represented by TREC investigators include basic science, endocrinology, epidemiology, biostatistics, behavior, medicine, nutrition, physical activity, genetics, engineering, health economics, and computer science. Approximately 41,000 participants will be involved in these studies, including children, healthy adults, and breast and prostate cancer survivors. Outcomes include biomarkers of cancer risk, changes in weight and physical activity, persistent adverse treatment effects (e.g., lymphedema, urinary and sexual function), and breast and prostate cancer mortality.
  
  
  CONCLUSIONS
  The NIH Science of Team Science group will evaluate the value added by this collaborative science. However, the most important outcome will be whether this transdisciplinary initiative improves the health of Americans at risk of cancer as well as cancer survivors.
authors: University of California, San Diego, La Jolla, CA, USA.
authors: Ruth E
authors: RE
authors: Patterson
authors: Graham A
authors: GA
authors: Colditz
authors: Frank B
authors: FB
authors: Hu
authors: Kathryn H
authors: KH
authors: Schmitz
authors: Rexford S
authors: RS
authors: Ahima
authors: Ross C
authors: RC
authors: Brownson
authors: Kenneth R
authors: KR
authors: Carson
authors: Jorge E
authors: JE
authors: Chavarro
authors: Lewis A
authors: LA
authors: Chodosh
authors: Sarah
authors: S
authors: Gehlert
authors: Jeff
authors: J
authors: Gill
authors: Karen
authors: K
authors: Glanz
authors: Debra
authors: D
authors: Haire-Joshu
authors: Karen Louise
authors: KL
authors: Herbst
authors: Christine M
authors: CM
authors: Hoehner
authors: Peter S
authors: PS
authors: Hovmand
authors: Melinda L
authors: ML
authors: Irwin
authors: Linda A
authors: LA
authors: Jacobs
authors: Aimee S
authors: AS
authors: James
authors: Lee W
authors: LW
authors: Jones
authors: Jacqueline
authors: J
authors: Kerr
authors: Adam S
authors: AS
authors: Kibel
authors: Irena B
authors: IB
authors: King
authors: Jennifer A
authors: JA
authors: Ligibel
authors: Jeffrey A
authors: JA
authors: Meyerhardt
authors: Loki
authors: L
authors: Natarajan
authors: Marian L
authors: ML
authors: Neuhouser
authors: Jerrold M
authors: JM
authors: Olefsky
authors: Enola K
authors: EK
authors: Proctor
authors: Susan
authors: S
authors: Redline
authors: Cheryl L
authors: CL
authors: Rock
authors: Bernard
authors: B
authors: Rosner
authors: David B
authors: DB
authors: Sarwer
authors: J Sanford
authors: JS
authors: Schwartz
authors: Dorothy D
authors: DD
authors: Sears
authors: Howard D
authors: HD
authors: Sesso
authors: Meir J
authors: MJ
authors: Stampfer
authors: S V
authors: SV
authors: Subramanian
authors: Elsie M
authors: EM
authors: Taveras
authors: Julia
authors: J
authors: Tchou
authors: Beti
authors: B
authors: Thompson
authors: Andrea B
authors: AB
authors: Troxel
authors: Marianne
authors: M
authors: Wessling-Resnick
authors: Kathleen Y
authors: KY
authors: Wolin
authors: Mark D
authors: MD
authors: Thornquist
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D035843:Biomedical Research; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D003299:Cooperative Behavior; D004734:Energy Metabolism; D015340:Epidemiologic Research Design; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D033183:Interdisciplinary Communication; D008297:Male; D008875:Middle Aged; D054547:National Cancer Institute (U.S.); D009316:National Institutes of Health (U.S.); D009369:Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D011379:Prognosis; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult
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