title: High-throughput approaches to understanding gene function and mapping network architecture in bacteria.
abstract: Advances in sequencing technology have provided an unprecedented view of bacterial diversity, along with a daunting number of novel genes. Within this new reality lies the challenge of developing large-scale approaches to assign function to the new genes and place them in pathways. Here, we highlight recent advances on this front, focusing on how high-throughput gene-gene, gene-drug and drug-drug interactions can yield functional and mechanistic inferences in bacteria.
authors: Genome Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg 69117, Germany.
authors: Ana Rita
authors: AR
authors: Brochado
authors: Athanasios
authors: A
authors: Typas
mesh_terms: D001419:Bacteria / Q000187:drug effects / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005827:Genetics, Microbial / Q000379:methods / Q000639:trends; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D008967:Molecular Biology / Q000379:methods / Q000639:trends