title: Association of dyslipidemia with renal outcomes in chronic kidney disease.
abstract: Dyslipidemia is highly prevalent in patients with chronic kidney disease (CKD) and the relationship between dyslipidemia with renal outcomes in patients with moderate to advanced CKD remains controversial. Hence, our objective is to determine whether dyslipidemia is independently associated with rapid renal progression and progression to renal replacement therapy (RRT) in CKD patients. The study analyzed the association between lipid profile, RRT, and rapid renal progression (estimated glomerular filtration rate [eGFR] slope <-6 ml/min/1.73 m(2)/yr) in 3303 patients with stages 3 to 5 CKD. During a median 2.8-year follow-up, 1080 (32.3%) participants commenced RRT and 841 (25.5%) had rapid renal progression. In the adjusted models, the lowest quintile (hazard ratios [HR], 1.23; 95% confidence interval [CI], 1.01 to 1.49) and the highest two quintiles of total cholesterol (HR, 1.25; 95% CI, 1.02 to 1.52 and HR, 1.35; 95% CI, 1.11 to 1.65 respectively) increased risks for RRT (vs. quintile 2). Besides, the highest quintile of total cholesterol was independently associated with rapid renal progression (odds ratio, 1.36; 95% CI, 1.01 to 1.83). Our study demonstrated that certain levels of dyslipidemia were independently associated with RRT and rapid renal progression in CKD stage 3-5. Assessment of lipid profile may help identify high risk groups with adverse renal outcomes.
authors: Division of Nephrology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Szu-Chia
authors: SC
authors: Chen
authors: Chi-Chih
authors: CC
authors: Hung
authors: Mei-Chuan
authors: MC
authors: Kuo
authors: Jia-Jung
authors: JJ
authors: Lee
authors: Yi-Wen
authors: YW
authors: Chiu
authors: Jer-Ming
authors: JM
authors: Chang
authors: Shang-Jyh
authors: SJ
authors: Hwang
authors: Hung-Chun
authors: HC
authors: Chen
mesh_terms: D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D018450:Disease Progression; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D017582:Renal Replacement Therapy / Q000706:statistics & numerical data; D012307:Risk Factors; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
references: Circulation. 2002 Dec 17;106(25):3143-421
references: 12485966
references: Lancet. 2007 Dec 1;370(9602):1829-39
references: 18061058
references: Am J Clin Nutr. 2005 Jun;81(6):1257-66
references: 15941874
references: J Am Soc Nephrol. 2006 Jul;17(7):2006-16
references: 16762986
references: Ren Fail. 2001 May-Jul;23(3-4):551-62
references: 11499569
references: Kidney Int. 2001 Jul;60(1):277-83
references: 11422762
references: Nephrol Dial Transplant. 2006 Nov;21(11):3106-14
references: 16720593
references: Hypertens Res. 2011 Sep;34(9):1052-8
references: 21753773
references: Am J Kidney Dis. 2002 Feb;39(2 Suppl 1):S1-266
references: 11904577
references: Kidney Int. 2002 May;61(5):1887-93
references: 11967041
references: Clin J Am Soc Nephrol. 2011 Dec;6(12):2750-8
references: 21980185
references: Kidney Int. 2000 Jul;58(1):293-301
references: 10886574
references: Am J Nephrol. 2004 Jan-Feb;24(1):46-53
references: 14707435
references: Atherosclerosis. 2002 Jan;160(1):141-6
references: 11755931
references: Clin J Am Soc Nephrol. 2010 Sep;5(9):1582-7
references: 20558558
references: Am J Nephrol. 2001 Nov-Dec;21(6):449-54
references: 11799261
references: Kidney Int. 1993 Jan;43(1):218-25
references: 8433562
references: Ann Intern Med. 1999 Mar 16;130(6):461-70
references: 10075613
references: Blood Purif. 2011;31(1-3):189-96
references: 21228589
references: JAMA. 2004 Jan 28;291(4):451-9
references: 14747502
references: Kidney Int. 2001 Jan;59(1):260-9
references: 11135079
references: Nephrol Dial Transplant. 2001;16 Suppl 1:40-4
references: 11369819
references: Lancet. 2011 Jun 25;377(9784):2181-92
references: 21663949
references: Kidney Int Suppl. 1999 Jul;71:S47-50
references: 10412736
references: J Am Soc Nephrol. 2010 Dec;21(12):2131-42
references: 20864686
references: Hemodial Int. 2006 Jan;10(1):1-7
references: 16441821
references: Am J Kidney Dis. 2008 Sep;52(3):412-24
references: 18676075
references: Kidney Blood Press Res. 2002;25(1):2-6
references: 11834870
references: J Am Soc Nephrol. 2003 Aug;14(8):2084-2091
references: 12874462
references: Am J Physiol Renal Physiol. 2006 Feb;290(2):F262-72
references: 16403839
references: Semin Dial. 2007 Nov-Dec;20(6):586-92
references: 17991209