title: General aspects and recent advances on bacterial protein toxins.
abstract: Bacterial pathogens produce protein toxins to influence host-pathogen interactions and tip the outcome of these encounters toward the benefit of the pathogen. Protein toxins modify host-specific targets through posttranslational modifications (PTMs) or noncovalent interactions that may inhibit or activate host cell physiology to benefit the pathogen. Recent advances have identified new PTMs and host targets for toxin action. Understanding the mechanisms of toxin action provides a basis to develop vaccines and therapies to combat bacterial pathogens and to develop new strategies to use toxin derivatives for the treatment of human disease.
authors: INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire, Microbial Toxins in Host-Pathogen Interactions, C3M, Université de Nice-Sophia-Antipolis, UFR Médecine, 06204 Nice, France. lemichez@unice.fr
authors: Emmanuel
authors: E
authors: Lemichez
authors: Joseph T
authors: JT
authors: Barbieri
mesh_terms: D000199:Actins / Q000187:drug effects; D001424:Bacterial Infections / Q000503:physiopathology; D001427:Bacterial Toxins / Q000145:classification / Q000494:pharmacology*; D020690:GTPase-Activating Proteins / Q000187:drug effects; D054884:Host-Pathogen Interactions / Q000502:physiology; D006801:Humans; D014176:Protein Biosynthesis / Q000187:drug effects; D011499:Protein Processing, Post-Translational / Q000502:physiology; D050600:SNARE Proteins / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D025801:Ubiquitin / Q000187:drug effects
chemical_list: D000199:Actins; D001427:Bacterial Toxins; D020690:GTPase-Activating Proteins; D050600:SNARE Proteins; D025801:Ubiquitin
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