title: Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease.
abstract: BACKGROUND
  Although empiric exclusion from the diet of the 6 food groups most likely to trigger allergies achieves eosinophilic esophagitis (EoE) remission in children, data on its prolonged efficacy and effects on adults are lacking.
  
  
  OBJECTIVE
  We sought to evaluate the efficacy of a 6-food elimination diet in inducing and maintaining prolonged remission in patients with adult EoE.
  
  
  METHODS
  Sixty-seven consecutive patients with adult EoE were prospectively recruited and treated exclusively with a diet avoiding cereals, milk, eggs, fish/seafood, legumes/peanuts, and soy for 6 weeks. Subsequent challenge was undertaken by sequentially reintroducing all excluded single foods, followed by endoscopy and biopsies, which were developed every 6 weeks in case of response (eosinophil peak count reduction to <15/high-power field [hpf]). A food was considered a trigger for EoE and removed from the diet if pathologic eosinophilic infiltration (≥15 eosinophils/hpf) reappeared. Food-specific serum IgE measurements and skin prick tests were performed before initiating the diet.
  
  
  RESULTS
  Forty-nine (73.1%) patients exhibited significantly reduced eosinophil peak counts (<15 eosinophils/hpf) before sequential single-food reintroduction. A single offending food antigen was identified in 35.71% of patients, 2 food triggers were identified in 30.95%, and 3 or more food triggers were identified in 33.3%. Cow's milk was the most common food antigen (61.9%), followed by wheat (28.6%), eggs (26.2%), and legumes (23.8%). Prior allergy tests showed no concordance with food-reintroduction challenge results. All patients who continued to avoid the offending foods maintained histopathologic and clinical EoE remission for up to 3 years.
  
  
  CONCLUSIONS
  An empiric 6-food elimination diet effectively induced remission of active adult EoE, which was maintained for up to 3 years with individually tailored, limited exclusion diets.
authors: Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Ciudad Real, Spain. alucendo@vodafone.es
authors: Alfredo J
authors: AJ
authors: Lucendo
authors: Ángel
authors: Á
authors: Arias
authors: Jesús
authors: J
authors: González-Cervera
authors: José Luis
authors: JL
authors: Yagüe-Compadre
authors: Danila
authors: D
authors: Guagnozzi
authors: Teresa
authors: T
authors: Angueira
authors: Susana
authors: S
authors: Jiménez-Contreras
authors: Sonia
authors: S
authors: González-Castillo
authors: Benito
authors: B
authors: Rodríguez-Domíngez
authors: Livia C
authors: LC
authors: De Rezende
authors: José M
authors: JM
authors: Tenias
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens; D057765:Eosinophilic Esophagitis / Q000178:diet therapy* / Q000276:immunology / Q000473:pathology; D005260:Female; D005502:Food; D005512:Food Hypersensitivity / Q000150:complications* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012882:Skin Tests; D055815:Young Adult
chemical_list: D000485:Allergens; D007073:Immunoglobulin E