title: [Lessons from the novel renoprotective studies with antihypertensive drugs].
abstract: From the evaluated ONTARGET, ALTITUDE, ACCOMPLISH, ROADMAP, and ACCORD-BP studies a conclusion can be drawn that though microalbuminuria/proteinuria is a strong epidemiological biomarker, in interventional studies it is not necessarily a reliable surrogate endpoint as actual renal function may change in an opposite way. Namely, some therapeutic measures improving microalbuminuria/proteinuria may actually worsen renal function. In case of procedures such as blood pressure lowering or measure of RAS blockade an optimum point on a J-curve may exist.
authors: Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ I. Belgyógyászati Klinika, Hetényi Géza Endokrinológiai és Anyagcsere Osztály Pécs Ifjúság út 13. 7624. laszlo.bajnok@aok.pte.hu
authors: László
authors: L
authors: Bajnok
mesh_terms: D017311:Amlodipine / Q000494:pharmacology* / Q000627:therapeutic use; D057911:Angiotensin Receptor Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011507:Proteinuria / Q000517:prevention & control; D000092502:Renin Inhibitors
chemical_list: D017311:Amlodipine; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D020011:Protective Agents; D000092502:Renin Inhibitors