title: A case of insulinoma detected by (68)Ga-DOTANOC PET/CT and missed by (18)F-dihydroxyphenylalanine PET/CT.
abstract: A 65-year-old woman with suspected insulinoma on the basis of clinical, biochemical, and conventional imaging data underwent F-dihydroxyphenylalanine (DOPA) PET/CT and Ga-DOTANOC PET/CT. F-DOPA PET/CT did not show any focal uptake in the pancreas, whereas Ga-DOTANOC PET/CT showed a focal area of intense uptake in the pancreatic tail. The patient underwent surgery and an insulinoma of about 20 mm in diameter was detected in the pancreatic tail. F-DOPA PET may fail in localizing insulin secreting tumors in adults; in these cases, the use of Ga-somatostatin analogs may lead to the correct diagnosis.
authors: Institute of Nuclear Medicine, Department of Bioimaging and Radiological Sciences, Catholic University of the Sacred Heart, Rome, Italy. giorgiomednuc@libero.it
authors: Giorgio
authors: G
authors: Treglia
authors: Frediano
authors: F
authors: Inzani
authors: Nicoletta
authors: N
authors: Campanini
authors: Guido
authors: G
authors: Rindi
authors: Salvatore
authors: S
authors: Agnes
authors: Alessandro
authors: A
authors: Giordano
authors: Vittoria
authors: V
authors: Rufini
mesh_terms: D000368:Aged; D004295:Dihydroxyphenylalanine; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D007340:Insulinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D064847:Multimodal Imaging; D009942:Organometallic Compounds; D011859:Radiography; D011877:Radionuclide Imaging; D051598:Whole Body Imaging
chemical_list: C504894:68Ga-DOTANOC; D005462:Fluorine Radioisotopes; D009942:Organometallic Compounds; D004295:Dihydroxyphenylalanine