title: T-cell immunoglobulin- and mucin-domain-containing molecule 3 genetic variants and HIV+ non-Hodgkin lymphomas.
abstract: T cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3) has been established as a negative regulatory molecule and plays a critical role in inflammatory diseases such as rheumatoid arthritis, hepatitis B and C, and human immunodeficiency virus (HIV)-related inflammation. Recent studies have shown that chronic inflammation may greatly affect the pathogenesis of non-Hodgkin lymphomas (NHL). The aim of this study was to investigate whether polymorphisms in the TIM-3 gene were associated with susceptibility to non-NHL and HIV-related NHL. Three polymorphisms in TIM-3 gene (-1516G/T, -574G/T, and +4259T/G) were identified by polymerase chain reaction-restriction fragment length polymorphism in 434 NHL patients, 62 HIV-related NHL cases, and 512 healthy controls. Results showed that the prevalence of -574GT genotype and +4259TG genotype were significantly increased in the NHL cases than in controls (odds ratio (OR) = 2.72, 95% confidence interval (CI) = 1.50-4.92, p = 0.0006 and OR = 2.59, 95% CI = 1.49-4.49, p = 0.0005, respectively). The -1516G/T polymorphism did not reveal significant difference between patients and healthy controls. When analyzing the TIM-3 polymorphisms in HIV-related NHL patients, data showed that HIV+ NHL patients had higher prevalence of -574GT or +4259TG genotypes than those cases without HIV infection (OR = 3.48, 95% CI = 1.67-7.28, p = 0.0005 and OR = 2.92, 95% CI = 1.42-6.01, p = 0.0026, respectively). These results suggested polymorphisms in TIM-3 gene could be new risk factors for NHL as well as HIV-related NHL and suggested a possible role of the inflammatory factor in these diseases.
authors: Department of Internal Medicine, Emergency Center, Shanghai East Hospital, Tongji University, 150 Jimo Road, Shanghai 200120, China.
authors: Haihan
authors: H
authors: Song
authors: Shaolin
authors: S
authors: Ma
authors: Zhanshan
authors: Z
authors: Cha
authors: Lei
authors: L
authors: Chen
authors: Danian
authors: D
authors: Tong
authors: Lan
authors: L
authors: Ma
authors: Weiguo
authors: W
authors: Song
authors: Jianwen
authors: J
authors: Bai
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000209:etiology / Q000235:genetics*; D000072597:Hepatitis A Virus Cellular Receptor 2; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000235:genetics* / Q000276:immunology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D018417:Th1 Cells / Q000378:metabolism
chemical_list: C448908:HAVCR2 protein, human; D000072597:Hepatitis A Virus Cellular Receptor 2; D008565:Membrane Proteins
references: Br J Haematol. 1995 Jun;90(2):235-43
references: 7794745
references: J Biol Chem. 1997 May 23;272(21):13803-9
references: 9153236
references: J Immunol. 2005 Feb 1;174(3):1405-15
references: 15661898
references: Mol Biol Rep. 2012 Nov;39(11):9941-6
references: 22733499
references: Blood. 2012 May 3;119(18):4192-204
references: 22438246
references: Annu Rev Immunol. 2000;18:593-620
references: 10837070
references: J Clin Invest. 2012 Apr;122(4):1271-82
references: 22426209
references: Ann Hematol. 2005 Jan;84(1):1-12
references: 15480663
references: Cancer Immunol Immunother. 2010 Dec;59(12):1851-7
references: 20811886
references: Immunol Rev. 2009 May;229(1):259-70
references: 19426227
references: J Clin Pathol. 2007 Dec;60(12):1365-72
references: 18042692
references: Expert Opin Ther Targets. 2007 Aug;11(8):1005-9
references: 17665973
references: Blood. 2006 Jan 1;107(1):13-20
references: 16099881
references: Br J Haematol. 2008 Aug;142(4):583-94
references: 18503581
references: Cytokine. 2008 Oct;44(1):9-13
references: 18706830
references: J Exp Med. 2010 Mar 15;207(3):505-20
references: 20176801
references: Mol Biol Rep. 2010 Jan;37(1):395-8
references: 19768575
references: J Exp Med. 2008 Nov 24;205(12):2699-701
references: 19015312
references: Eur J Immunol. 2010 Sep;40(9):2493-505
references: 20623550
references: Am J Physiol Regul Integr Comp Physiol. 2002 Jul;283(1):R7-28
references: 12069927
references: Hum Immunol. 2004 Dec;65(12):1427-31
references: 15603868
references: DNA Cell Biol. 2012 Jul;31(7):1285-9
references: 22472081
references: Immunol Lett. 2004 Aug 15;95(1):91-5
references: 15325803
references: J Exp Med. 2008 Nov 24;205(12):2763-79
references: 19001139