title: Evolutionary history and spatiotemporal dynamics of dengue virus type 1 in Asia.
abstract: Previous studies showed that DENV-1 transmitted from monkeys to humans approximately 125 years ago. However, there is no comprehensive analysis about phylogeography and population dynamics of Asian DENV-1. Here, we adopt a Bayesian phylogeographic approach to investigate the evolutionary history and phylogeography of Asian DENV-1 using envelope (E) protein gene sequences of 450 viruses isolated from 1954 to 2010 throughout 18 Asian countries and regions. Bayesian phylogeographic analyses indicate that the high rates of viral migration possibly follows long-distance travel for humans in Southeast Asia. Our study highlights that Southeast Asian countries have acted as the main viral sources of the dengue epidemics in East Asia. The results reveal that the time to the most recent common ancestor (TMRCA) of Asian DENV-1 is 1906 (95% HPD, years 1897-1915). We show that the spatial dissemination of virus is the major source of DENV-1 outbreaks in the different localities and leads to subsequent establishment and expansion of the virus in these areas.
authors: Department of Immunology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China. sunyan198112@yahoo.com.cn
authors: Yan
authors: Y
authors: Sun
authors: Shengli
authors: S
authors: Meng
mesh_terms: D001208:Asia / Q000453:epidemiology; D001499:Bayes Theorem; D003715:Dengue / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D003716:Dengue Virus / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D058974:Phylogeography; D014759:Viral Envelope Proteins / Q000235:genetics
chemical_list: D014759:Viral Envelope Proteins; C072281:E protein TH Sman, Dengue virus