title: Toxicological evaluation of pure hydroxytyrosol.
abstract: Of all the phenolic constituents of olives and extra virgin olive oil, hydroxytyrosol is currently being actively exploited as a potential supplement or preservative to be employed in the nutraceutical, cosmeceutical, and food industry. In terms of safety profile, hydroxytyrosol has only been investigated as the predominant part of raw olive mill waste water extracts, due to the previous unavailability of appropriate quantities of the pure compound. We report the toxicological evaluation of hydroxytyrosol and, based on the results, propose a No Observed Adverse Effects Level (NOAEL) of 500mg/kg/d.
authors: Seprox Biotech, Madrid, Spain; Harlan Laboratories S.A., Barcelona, Spain.
authors: David
authors: D
authors: Auñon-Calles
authors: Lourdes
authors: L
authors: Canut
authors: Francesco
authors: F
authors: Visioli
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D008124:Locomotion / Q000187:drug effects; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests
chemical_list: C005975:3,4-dihydroxyphenylethanol; D010626:Phenylethyl Alcohol