title: Non-small cell lung cancer evaluated with quantitative contrast-enhanced CT and PET-CT: net enhancement and standardized uptake values are related to tumour size and histology.
abstract: BACKGROUND
  Personalized cancer therapy remains a challenge. In this context, we attempted to identify correlations between tumour angiogenesis, tumour metabolism and tumour cell type. To this aim, we used single=phase multidetector computed tomography (MDCT) and hybrid positron emission tomography-computed tomography (PET/CT) to determine whether net enhancement and standardized uptake value (SUVmax) were correlated with tumour size and cytology in patients affected by non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Our study included 38 patients (30 men, 8 women, mean age 70) with a NSCLC measuring between 3 cm and 7 cm, using a 16-slice multidetector CT (Brilliance Philips) and with PET-CT (Biograph 16 Siemens Medical Solutions). The following lesion parameters were evaluated: maximum diameter, medium density before contrast injection (CTpre), medium density after contrast injection (CTpost average), density in the most enhanced part of the lesion after contrast (CTpost max), net enhancement, SUVmax, age, and cytology. Correlation coefficient and p-value were computed for each pair of variables. In addition, correlations were computed for each pair of variables, and for all combinations of tumour types. We focused on subsets of data with more than 10 observations, and with correlation r>0.500 and p<0.05.
  
  
  RESULTS
  A weak correlation (r=0.32; p=0.048) was found between SUVmax and tumour size; the correlation was stronger for masses larger than 31 mm (r=0.4515; p=0.0268). No other correlations were found among the variables examined.
  
  
  CONCLUSIONS
  Our data may have prognostic significance, and could lead to more appropriate surgical treatment and better treatment outcome.
authors: Department of Medicine and Health Sciences, Università del Molise, Contrada Tappino, Campobasso, Italy. lucabrunese@libero.it
authors: Luca
authors: L
authors: Brunese
authors: Barbara
authors: B
authors: Greco
authors: Francesca Rosa
authors: FR
authors: Setola
authors: Francesco
authors: F
authors: Lassandro
authors: Mario Rosario
authors: MR
authors: Guarracino
authors: Marialiusa
authors: M
authors: De Rimini
authors: Sergio
authors: S
authors: Piccolo
authors: Nicolina
authors: N
authors: De Rosa
authors: Roberto
authors: R
authors: Muto
authors: Andrea
authors: A
authors: Bianco
authors: Pietro
authors: P
authors: Muto
authors: Roberto
authors: R
authors: Grassi
authors: Antonio
authors: A
authors: Rotondo
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D003287:Contrast Media; D019788:Fluorodeoxyglucose F18
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