title: microRNAs in parasites and parasite infection.
abstract: miRNAs, a subclass of small regulatory RNAs, are present from ancient unicellular protozoans to parasitic helminths and parasitic arthropods. The miRNA-silencing mechanism appears, however, to be absent in a number of protozoan parasites. Protozoan miRNAs and components of their silencing machinery possess features different from other eukaryotes, providing some clues on the evolution of the RNA-induced silencing machinery. miRNA functions possibly associate with neoblast biology, development, physiology, infection and immunity of parasites. Parasite infection can alter host miRNA expression that can favor both parasite clearance and infection. miRNA pathways are, thus, a potential target for the therapeutic control of parasitic diseases.
authors: State Key Laboratory of Veterinary Etiological Biology; Key Laboratory of Veterinary Parasitology of Gansu Province; Lanzhou Veterinary Research Institute; CAAS; Lanzhou; Gansu, China; Key Lab of New Animal Drug Project, Gansu Province; Key Lab of Veterinary Pharmaceutical Development, Ministry of Agriculture; Lanzhou Institute of Husbandry and Pharmaceutical Sciences; CAAS; Lanzhou; Gansu, China; School of Biology; University of Nottingham; Nottingham, UK.
authors: Yadong
authors: Y
authors: Zheng
authors: Xuepeng
authors: X
authors: Cai
authors: Janette E
authors: JE
authors: Bradley
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D010271:Parasites / Q000235:genetics* / Q000378:metabolism; D010272:Parasitic Diseases / Q000188:drug therapy / Q000235:genetics* / Q000469:parasitology*; D034622:RNA Interference; D018510:RNA, Helminth / Q000235:genetics / Q000378:metabolism; D016053:RNA, Protozoan / Q000235:genetics / Q000378:metabolism; D020537:RNA, Small Nucleolar / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000977:Antiparasitic Agents; D035683:MicroRNAs; D018510:RNA, Helminth; D016053:RNA, Protozoan; D020537:RNA, Small Nucleolar
keywords: helminth; miRNA; neoblast; protozoan; snoRNA
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