title: Serum Cholesterol and Ceruloplasmin Levels in Second Trimester can Predict Development of Pre-eclampsia.
abstract: BACKGROUND
  Pre-eclampsia is one of the leading causes of high rates of maternal and perinatal mortality and morbidity. Pathophysiology of pre-eclampsia is still obscure. Currently, there are no screening tests for pre-eclampsia that are reliable, valid, and economical. Parameters of oxidative stress could be early markers of endothelial dysfunction that predates clinical pre-eclampsia.
  
  
  OBJECTIVE
  This study was to study ceruloplasmin in nulliparous women as marker of oxidative stress and lipid profile to evaluate their value in prediction of pre-eclampsia.
  
  
  METHODS
  Prospective observational study. 306 nulliparous women had their serum lipid profile and ceruloplasmin levels measured at 14-16 weeks period of gestation as sample 1 and at 18-20 weeks as sample 2. All cases were followed up till the end of pregnancy for development of pre-eclampsia.
  
  
  RESULTS
  There was no statistically significant difference between the normals and pre-eclampsia cases at 14-16 week for all the oxidative stress parameters (P > 0.05), but at 18-20 week, there was statistically significant difference between the normals and pre-eclampsia cases in cholesterol and ceruloplasmin parameters (P < 0.05).
  
  
  CONCLUSIONS
  Cholesterol and ceruloplasmin levels in second trimester (18-20 weeks) can predict the development of pre-eclampsia.
authors: Department of Obstetrics and Gynaecology, Armed Forces Medical Services, India.
authors: Madhusudan
authors: M
authors: Dey
authors: Devendra
authors: D
authors: Arora
authors: Nagarja
authors: N
authors: Narayan
authors: Reema
authors: R
authors: Kumar
keywords: Ceruloplasmin; Cholesterol; Lipid profile; Oxidative stress; Pre-eclampsia
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