title: Association of Morbus Ledderhose with Dupuytren's contracture.
abstract: BACKGROUND
  Fibromatous nodules in the sole of the foot are often called Ledderhose disease. It is a benign nodular formation in the plantar aponeurosis, typically at the distal medial border. A lump forms and it can be a few centimeters in diameter. It is frequently seen as an isolated disease, but a relationship to Dupuytren's has been noted in some patients.
  
  
  METHODS
  The study was a part of a large cohort study, the Reykjavík study. Men with Dupuytren's disease (n = 122) were invited to follow-up 18 years after the initial observation. An equal number of controls, matched for age and smoking habits, were also invited. A total of 92 Dupuytren's patients and 101 control subjects attended for follow-up and were examined for plantar nodules. Statistical evaluation was carried out using chi-square test and presented as odds ratio (OR) and 95% confidence interval (95% CI).
  
  
  RESULTS
  Ledderhose disease was identified in 14 of the 92 (15.2%) men with Dupuytren's disease, while it was only in 4 of the 101 (3.9%) matched controls (OR = 4.35, 95% CI, 1.3-16.7, P < 0.01). Men operated for Dupuytren's disease or with finger contractures were more likely to have plantar nodules than those with only nodules or strings in the palms (OR = 6.1, 95% CI, 1.8-27.1, P < 0.001). The plantar involvement was related to family history of Dupuytren's disease (OR = 3.1, 95% CI, 1.1-8.5, P = 0.02).
  
  
  CONCLUSIONS
  Men with manifestations of finger contractures or who need surgery for Dupuytren's disease are more likely to also develop plantar fibromas.
  
  
  METHODS
  Level III, retrospective comparative series.
authors: Reykjavik Primary Health Care, Glaesibaer, 104 Reykjavik, Iceland. kristgud@simmet.is
authors: Kristján G
authors: KG
authors: Gudmundsson
authors: Thorbjörn
authors: T
authors: Jónsson
authors: Reynir
authors: R
authors: Arngrímsson
mesh_terms: D017668:Age of Onset; D016022:Case-Control Studies; D004387:Dupuytren Contracture / Q000150:complications* / Q000235:genetics / Q000601:surgery; D005350:Fibroma / Q000150:complications*; D005500:Follow-Up Studies; D005534:Foot Diseases / Q000150:complications*; D006801:Humans; D007055:Iceland; D008297:Male
keywords: Dupuytren’s disease; Ledderhose disease; epidemiology; plantar fascia; plantar fibromatosis