title: Diagnostic value of circulating microRNAs for lung cancer: a meta-analysis.
abstract: BACKGROUND
  Lung cancer is a leading cause of cancer mortality, and it shows a high incidence worldwide. Circulating microRNAs have been proposed as diagnostic indicators of lung cancer, but inconsistent results in the literature have prevented their widespread use in diagnosis. The present meta-analysis aimed to systematically evaluate the diagnostic accuracy of circulating microRNAs for lung cancer.
  
  
  METHODS
  Several research databases were searched systematically for studies of the accuracy of circulating microRNAs as diagnostic indicators of lung cancer. Results from different studies were pooled using random-effects models. Summary receiver operating characteristic (SROC) curves were used to assess the overall performance of microRNA-based assays.
  
  
  RESULTS
  Thirteen publications were included in the meta-analysis. The following summary estimates were obtained for the performance of circulating microRNAs in lung cancer diagnosis: sensitivity, 0.85 (95% confidence intervals [CI]: 0.83-0.87); specificity, 0.84 (95% CI: 0.81-0.86); positive likelihood ratio, 5.23 (95% CI: 3.75-7.29); negative likelihood ratio, 0.20 (95% CI: 0.14-0.27); and diagnostic odds ratio, 31.77 (95% CI: 16.98-59.42). The SROC curve indicated a maximum joint sensitivity and specificity of 0.85, with an area under the curve of 0.92.
  
  
  CONCLUSIONS
  Circulating microRNAs show significant potential as diagnostic markers of lung cancer. The results of this meta-analysis justify larger, more rigorous studies to confirm such a diagnostic role.
authors: State Key Laboratory of Biotherapy of China, Division of Pulmonary Diseases, Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
authors: Yongchun
authors: Y
authors: Shen
authors: Tao
authors: T
authors: Wang
authors: Ting
authors: T
authors: Yang
authors: Qianjing
authors: Q
authors: Hu
authors: Chun
authors: C
authors: Wan
authors: Lei
authors: L
authors: Chen
authors: Fuqiang
authors: F
authors: Wen
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D035683:MicroRNAs / Q000097:blood*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D035683:MicroRNAs
references: J Clin Epidemiol. 2005 Sep;58(9):882-93
references: 16085191
references: Ann Intern Med. 2008 Dec 16;149(12):889-97
references: 19075208
references: BMC Med Res Methodol. 2006 Mar 06;6:9
references: 16519814
references: Radiology. 2011 Jan;258(1):243-53
references: 21045183
references: Clin Cancer Res. 2010 Jan 15;16(2):610-9
references: 20068099
references: Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3713-8
references: 21300873
references: CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300
references: 20610543
references: Stat Med. 2002 May 15;21(9):1237-56
references: 12111876
references: BMJ. 2004 Jul 17;329(7458):168-9
references: 15258077
references: EMBO Mol Med. 2011 Aug;3(8):495-503
references: 21744498
references: Zhongguo Fei Ai Za Zhi. 2010 Dec;13(12):1136-40
references: 21159250
references: Mol Med Rep. 2011 Mar-Apr;4(2):383-7
references: 21468581
references: Lung Cancer. 2011 Oct;74(1):41-7
references: 21388703
references: Expert Rev Mol Diagn. 2011 Nov;11(8):763-6
references: 22022936
references: Surg Oncol Clin N Am. 2011 Oct;20(4):619-35
references: 21986261
references: BMC Cancer. 2011 Aug 24;11:374
references: 21864403
references: Lab Invest. 2011 Apr;91(4):579-87
references: 21116241
references: J Natl Cancer Inst. 2010 May 5;102(9):605-13
references: 20413742
references: EMBO Mol Med. 2011 Aug;3(8):436-7
references: 21739607
references: Front Med. 2012 Jun;6(2):134-55
references: 22528868
references: Int J Cancer. 2012 Apr 1;130(7):1620-8
references: 21557218
references: Nat Rev Genet. 2012 Apr 18;13(5):358-69
references: 22510765
references: Chin J Cancer. 2011 Jun;30(6):407-14
references: 21627863
references: Int J Clin Exp Pathol. 2011 Aug 15;4(6):575-86
references: 21904633
references: J Clin Oncol. 2010 Oct 10;28(29):e573-4; author reply e575-6
references: 20697097
references: BMC Med Res Methodol. 2002 Jul 03;2:9
references: 12097142
references: Ann Thorac Surg. 2005 Jan;79(1):16-20
references: 15620907
references: PLoS One. 2012;7(2):e32307
references: 22389695
references: Int J Cancer. 2012 Mar 15;130(6):1378-86
references: 21544802
references: J Clin Epidemiol. 2003 Nov;56(11):1129-35
references: 14615004
references: Clin Chem. 2008 Oct;54(10):1696-704
references: 18719201
references: Cell Res. 2008 Oct;18(10):997-1006
references: 18766170
references: J Thorac Oncol. 2011 Mar;6(3):482-8
references: 21258252
references: JAMA. 2007 Mar 7;297(9):953-61
references: 17341709
references: J Clin Oncol. 2010 Apr 1;28(10):1721-6
references: 20194856
references: J Cancer Res Clin Oncol. 2012 Dec;138(12):2045-50
references: 22806310
references: J Cancer Res Clin Oncol. 2012 Oct;138(10):1659-66
references: 22638884
references: J Clin Epidemiol. 2009 Oct;62(10):1006-12
references: 19631508
references: Zhongguo Fei Ai Za Zhi. 2010 May;13(5):488-93
references: 20677647
references: Oncol Lett. 2011 Sep 1;2(5):991-994
references: 22866162