title: Hand-holding for retrohoming in a molecular diversity dance.
abstract: In bacterial systems, adaptive protein sequence changes can be mediated by diversity-generating retroelements in a process known as retrohoming. An accessory variability determinant (Avd), together with a reverse transcriptase (RT), is critically involved in this process. In this issue of Structure, Alayyoubi and colleagues describe the structure of Avd as a basis for interactions with RT that promote retrohoming.
authors: Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA.
authors: Joachim
authors: J
authors: Jaeger
authors: Marlene
authors: M
authors: Belfort
mesh_terms: D001435:Bacteriophages / Q000201:enzymology*; D001884:Bordetella / Q000821:virology*; D012194:RNA-Directed DNA Polymerase / Q000737:chemistry*; D018626:Retroelements; D014764:Viral Proteins / Q000737:chemistry*
chemical_list: D018626:Retroelements; D014764:Viral Proteins; D012194:RNA-Directed DNA Polymerase
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