title: Sleep status and low-density lipoprotein particle size in a general Japanese female population: the MIMA study.
abstract: OBJECTIVE
  This study investigated the relationship between sleep adequacy and small dense low-density lipoprotein (sdLDL) in a Japanese population.
  
  
  METHODS
  Clinical data, including atherosclerotic risk factors, in addition to the mean LDL particle size (LDL-PS) measured by gel electrophoresis, were evaluated in 136 community-dwelling female subjects (40-80 years old). The sleep status was self-reported and the subjects were divided into those who had inadequate sleep (≤ 6 or ≥ 9 h of sleep) and had adequate sleep (7-8 h).
  
  
  RESULTS
  The mean LDL-PS was significantly smaller in subjects with inadequate sleep [n = 68, 26.4 ± 0.4 (SD) nm] than in those with adequate sleep (n = 68, 26.6 ± 0.4 nm, p < 0.05). This difference remained significant and independent after adjusting for confounders (β = 0.15-0.19, p < 0.05).
  
  
  CONCLUSIONS
  Sleep adequacy was associated with the presence of sdLDL, while the influence of the sleep status on LDL-PS was minor in this population. Further research on the associations among sleep, sdLDL and cardiovascular disease prevention is warranted.
authors: Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors: Kazuhiko
authors: K
authors: Kotani
authors: Kokoro
authors: K
authors: Tsuzaki
authors: Shinji
authors: S
authors: Fujiwara
authors: Naoki
authors: N
authors: Sakane
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000737:chemistry*; D005260:Female; D015438:Health Behavior; D006304:Health Status; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D010316:Particle Size; D012307:Risk Factors; D057566:Self Report; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000097:blood* / Q000378:metabolism
chemical_list: D008078:Cholesterol, LDL
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