title: Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study.
abstract: BACKGROUND
  Prevention of chronic kidney disease (CKD) is a major public health issue. Although several studies have been performed on the association between alcohol consumption and CKD or renal function, it remains controversial. Numerous genetic polymorphisms have been reported to be associated with CKD and kidney function. Mitochondrial DNA cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in Japanese. This polymorphism modifies the effects of alcohol consumption on blood pressure, risk of hypertension, serum triglyceride levels, risk of hyper-LDL cholesterolemia and serum uric acid levels. The objective of this study was to investigate whether Mt5178 C/A polymorphism modifies the effects of alcohol consumption on renal function in male Japanese health check-up examinees.
  
  
  METHODS
  A total of 394 male subjects aged 29-76 years were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effects of Mt5178 C/A polymorphism and habitual drinking on the risk of mildly decreased estimated glomerular filtration rate (eGFR) (<90 ml/min/1.73 m(2)) was conducted.
  
  
  RESULTS
  For Mt5178A genotypic men, habitual drinking may increase eGFR (P for trend = 0.003) or reduce the risk of mildly decreased eGFR (P for trend = 0.003). Daily drinkers had a significantly higher eGFR than non-drinkers (P = 0.005). The crude odds ratio for decreased eGFR was significantly lower in daily drinkers than in non-drinkers (odds ratio = 0.092, 95% confidence interval: 0.012-0.727, P = 0.024). On the other hand, for Mt5178C genotypic men, habitual drinking does not appear to affect eGFR.
  
  
  CONCLUSIONS
  The present results suggest a joint effect of Mt5178 C/A polymorphism and alcohol consumption on eGFR and the risk of mildly decreased eGFR in male Japanese subjects.
authors: Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Tokyo 142-8555, Japan. akokaze@med.showa-u.ac.jp
authors: Akatsuki
authors: A
authors: Kokaze
authors: Mamoru
authors: M
authors: Ishikawa
authors: Naomi
authors: N
authors: Matsunaga
authors: Kanae
authors: K
authors: Karita
authors: Masao
authors: M
authors: Yoshida
authors: Naoki
authors: N
authors: Shimada
authors: Tadahiro
authors: T
authors: Ohtsu
authors: Takako
authors: T
authors: Shirasawa
authors: Hirotaka
authors: H
authors: Ochiai
authors: Hiromi
authors: H
authors: Hoshino
authors: Yutaka
authors: Y
authors: Takashima
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000235:genetics*; D003430:Cross-Sectional Studies; D004272:DNA, Mitochondrial / Q000235:genetics*; D005919:Glomerular Filtration Rate / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018570:Risk Assessment
chemical_list: D004272:DNA, Mitochondrial
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