title: A general preparation of (Z)-1-fluorostilbene derivatives for the design of conformationally restricted peptidomimetics.
abstract: The preparation of (Z)-1-fluoro-2-bromostyrenes provides a general route for the formation of (Z)-1-fluorostilbene derivatives as configurationally stable spacial linkers for the design of conformationally restricted peptidomimetics. Palladium-catalyzed aryl Suzuki and Stille cross-coupling reactions have been surveyed to proceed with complete retention of fluoroalkene geometry, and permit the direct incorporation of a variety of aryl and heteroaromatic substituents.
authors: Department of Chemistry, Indiana University, Bloomington, Indiana 47405, U. S. A.
authors: David R
authors: DR
authors: Williams
authors: Micheal
authors: M
authors: Fultz
authors: Thomas E
authors: TE
authors: Christos
authors: Jeffery S
authors: JS
authors: Carter
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