title: HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature.
abstract: Primary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic lymphoid cells are frequently infected with human herpes virus 8 (HHV8), also known as Kaposi sarcoma herpes virus (KSHV). We describe two HIV-negative patients who presented with primary effusion lymphoma of B-cell lineage involving the pleural cavity, but whose tumor cells lacked infection by HHV8. We review the English language literature of HHV8-negative PEL of B-cell lineage and compare these lymphomas to HHV8-associated PEL with regard to clinical and pathological characteristics, therapy, and outcome.
authors: Department of Internal Medicine, North Shore Medical Center, Salem, MA 01970, USA.
authors: Neeraj
authors: N
authors: Saini
authors: Ephraim P
authors: EP
authors: Hochberg
authors: Erica A
authors: EA
authors: Linden
authors: Smita
authors: S
authors: Jha
authors: Heinz K
authors: HK
authors: Grohs
authors: Aliyah R
authors: AR
authors: Sohani
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