title: [WNT-β-catenin signaling pathway and its relationship with cancer].
abstract: The Wnt-β-catenin signalling pathway plays a crucial role in the regulation, differentiation, proliferation and cellular death processes; consequently, alterations in this pathway are involved in numerous abnormalities of development, growth and homeostasis in animal organisms. Wnt proteins include a numerous family of secretion glycoproteins which join to Frizzled receptors and Low Density Lipoprotein Receptor-related Protein, in order to stabilize the critical β-catenin protein, and to initiate an intricate signaling cascade, which is related to multiple nucleocytoplasmatic processes. Alterations in the canonical Wnt-β-catenin signaling pathway have been associated with variations in a number of proteins participating in this route, or with activation / inactivation of oncogenes and tumor suppressor genes, which explain different processes of tumorigenesis, in addition to a number of malformations and human diseases. This review describes the relations between the Wnt-β-catenin signaling pathway with different neoplasic processes, as well as its application in the diagnosis and prognosis of cancer.
authors: División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
authors: Alejandra Berenice
authors: AB
authors: Ochoa-Hernández
authors: Clara Ibet
authors: CI
authors: Juárez-Vázquez
authors: Mónica Alejandra
authors: MA
authors: Rosales-Reynoso
authors: Patricio
authors: P
authors: Barros-Núñez
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D015316:Genetic Therapy; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D007938:Leukemia / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D058990:Molecular Targeted Therapy; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D051153:Wnt Proteins / Q000502:physiology; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000502:physiology
chemical_list: C495270:CTNNB1 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D051153:Wnt Proteins; D051176:beta Catenin