title: Blockage of glucocorticoid receptors during memory acquisition, retrieval and reconsolidation prevents the expression of morphine-induced conditioned place preferences in mice.
abstract: Association between the reward caused by consuming drugs and the context in which they are consumed is essential in the formation of morphine-induced conditioned place preference (CPP). Glucocorticoid receptor (GRs) activation in different regions of the brain affects reward-based reinforcement and memory processing. A wide array of studies have demonstrated that blockage of GRs in some brain areas can have an effect on reward-related memory; however, to date there have been no systematic studies about the involvement of glucocorticoids (GCs) in morphine-related reward memory. Here, we used the GR antagonist RU38486 to investigate how GRs blockage affects the sensitization and CPP behavior during different phases of reward memory included acquisition, retrieval and reconsolidation. Interestingly, our results showed RU38486 has the ability to impair the acquisition, retrieval and reconsolidation of reward-based memory in CPP and sensitization behavior. But RU38486 by itself cannot induce CPP or conditioned place aversion (CPA) behavior. Our data provide a much more complete picture of the potential effects that glucocorticoids have on the reward memory of different phases and inhibit the sensitization behavior.
authors: Department of Neurosurgery, The Third Affiliated Hospital of Kunming Medical University (Yunnan Province Tumor Hospital), Kunming  650118, China.
authors: Yao-Dong
authors: YD
authors: Fan
authors: Hai-Chen
authors: HC
authors: Niu
authors: Tanzeel
authors: T
authors: Huma
authors: Ling
authors: L
authors: Li
authors: Gui-Mei
authors: GM
authors: Wang
authors: Li-Qi
authors: LQ
authors: Xu
authors: He
authors: H
authors: Ren
authors: Yuan-Ye
authors: YY
authors: Ma
authors: Hua-Lin
authors: HL
authors: Yu
mesh_terms: D000818:Animals; D008568:Memory / Q000187:drug effects; D051379:Mice; D015735:Mifepristone; D009020:Morphine / Q000494:pharmacology; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid; D012201:Reward
chemical_list: D011965:Receptors, Glucocorticoid; D015735:Mifepristone; D009020:Morphine
keywords: Addiction; Conditioned place preference; Glucocorticoid receptor; RU38486; Reconsolidation; Retrieval; Reward memory