title: Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia.
authors: S E M
authors: SE
authors: Herman
authors: P M
authors: PM
authors: Barr
authors: E M
authors: EM
authors: McAuley
authors: D
authors: D
authors: Liu
authors: A
authors: A
authors: Wiestner
authors: J W
authors: JW
authors: Friedberg
mesh_terms: D000631:Aminopyridines; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000378:metabolism*; D009025:Morpholines; D010078:Oxazines / Q000494:pharmacology* / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use; D011743:Pyrimidines; D011947:Receptors, Antigen, B-Cell / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000631:Aminopyridines; D000970:Antineoplastic Agents; D009025:Morpholines; D010078:Oxazines; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D011743:Pyrimidines; D011947:Receptors, Antigen, B-Cell; C523665:fostamatinib
references: N Engl J Med. 2005 Feb 24;352(8):804-15
references: 15728813
references: Blood. 2011 Jan 13;117(2):563-74
references: 20940416
references: Blood. 2010 Dec 2;116(23):4894-905
references: 20716772
references: J Exp Med. 2004 Aug 16;200(4):519-25
references: 15314077
references: Leukemia. 2009 Apr;23(4):686-97
references: 19092849
references: Hematology Am Soc Hematol Educ Program. 2012;2012:88-96
references: 23233565
references: Blood. 2010 Jun 3;115(22):4497-506
references: 20335218
references: Blood. 2004 Nov 1;104(9):2879-85
references: 15217826
references: Blood. 2009 Jul 30;114(5):1029-37
references: 19491390
references: J Immunol. 1996 Jan 1;156(1):100-7
references: 8598449
references: Blood. 2010 Sep 23;116(12):2078-88
references: 20522708
references: Blood. 2011 Jun 9;117(23):6287-96
references: 21422473
references: Blood. 2005 Mar 1;105(5):2036-41
references: 15514014
references: Leukemia. 2012 Jul;26(7):1576-83
references: 22362000
references: Blood. 2010 Apr 1;115(13):2578-85
references: 19965662