title: Predicting prostate biopsy outcome using a PCA3-based nomogram in a Polish cohort.
abstract: BACKGROUND
  Prostate Cancer Gene-3 (PCA3) is highly prostate cancer (PCa)-specific and its application holds promise in identifying men with PCa.
  
  
  OBJECTIVE
  To determine whether the PCA3 score can be used relative to PCa clinical variables to predict biopsy outcome.
  
  
  METHODS
  PCA3 scores were assessed in a group of 80 patients using the Progensa assay (Gen-Probe, San Diego, CA, USA). The logistic regression algorithm was used to combine PCA3 results with the established biopsy risk factors including: age, prostate-specific antigen (PSA), digital rectal examination (DRE) and prostate volume (Pvol).
  
  
  RESULTS
  In univariate analyses, the Progensa PCA3 score outperformed all biopsy risk predictors. A logistic regression algorithm using: age, PCA3, PSA, DRE and Pvol increased the area under the Receiver Operating Characteristic (ROC) curve from 0.72 for PCA3-alone to 0.85.
  
  
  CONCLUSIONS
  Combining PCA3 results with PCa risk factors provides significant improvements over the use of PCA3- or PSA-alone in predicting the probability of a positive prostate biopsy.
authors: 267 Experimental Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands. J.Schalken@uro.umcn.nl
authors: Maciej
authors: M
authors: Salagierski
authors: Peter
authors: P
authors: Mulders
authors: Jack A
authors: JA
authors: Schalken
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000951:Antigens, Neoplasm / Q000652:urine*; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D049451:Nomograms; D011044:Poland; D017430:Prostate-Specific Antigen / Q000652:urine; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000652:urine; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C479341:prostate cancer antigen 3, human; D017430:Prostate-Specific Antigen