title: A critical analysis on the impact of antiplatelet therapy in the patency of infrainguinal bypass grafts.
abstract: Antiplatelet therapy plays an important role in the management of atherosclerotic disease and numerous studies have shown their efficacy in the reduction of cardiovascular mortality and morbidity. Antiplatelets are given in patients subjected to lower limb bypass aiming not only to reduce cardiovascular mortality and morbidity but also improve graft patency. Various antiplatelet agents have been used for this purpose. The aim of this review article is to critically evaluate the existing evidence on the impact of antiplatelet therapy for maintaining infrainguinal graft patency and highlight the mechanisms involved along these lines.
authors: Vascular Surgery Department, Attikon University Hospital, Athens, Greece.
authors: George S
authors: GS
authors: Sfyroeras
authors: Vassileios
authors: V
authors: Saleptsis
authors: Christos
authors: C
authors: Argyriou
authors: Georgios A
authors: GA
authors: Antoniou
authors: Frans L
authors: FL
authors: Moll
authors: Athanasios D
authors: AD
authors: Giannoukas
mesh_terms: D001026:Coronary Artery Bypass / Q000379:methods*; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply / Q000601:surgery; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D014654:Vascular Patency / Q000187:drug effects*
chemical_list: D010975:Platelet Aggregation Inhibitors