title: Merkel cell carcinoma from 2008 to 2012: reaching a new level of understanding.
abstract: Merkel cell carcinoma (MCC) is a rare primary cutaneous carcinoma of the skin who has high aggressiveness, high risk of locoregional and distant spread, a mortality rate considerably higher than that of cutaneous melanoma and a poor survival. Its incidence has increased during the past twenty years. The studies published from 2008 to early 2012 have introduced interesting changes in the understanding of its epidemiology, pathogenesis and consequently in the diagnostic codes and the therapeutic approach. Early and detailed nodal diagnosis with posterior multidisciplinary decision is mandatory. Surgery and Radiotherapy play a fundamental role in the management of this tumor. Both are associated with improved locoregional control and disease free survival; but patients continue to have distant failure because, currently, there is no effective systemic treatment available. Consequently, there remain controversies about its appropriate management, and this review is an attempt to contribute to their clarification.
authors: Radiation Oncology Department, Capio Fundación Jiménez Díaz University Hospital, Avenida Reyes Católicos No. 2, 28040 Madrid, Spain. iprieto@fjd.es
authors: Isabel
authors: I
authors: Prieto Muñoz
authors: Jose
authors: J
authors: Pardo Masferrer
authors: Jesús
authors: J
authors: Olivera Vegas
authors: Maria Susana
authors: MS
authors: Medina Montalvo
authors: Raquel
authors: R
authors: Jover Díaz
authors: Ana Maria
authors: AM
authors: Pérez Casas
mesh_terms: D015266:Carcinoma, Merkel Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*