title: Genome of the Chinese tree shrew.
abstract: Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as models for a variety of human disorders: depression, myopia, hepatitis B and C virus infections, and hepatocellular carcinoma, to name a few. Here we present a publicly available annotated genome sequence for the Chinese tree shrew. Phylogenomic analysis of the tree shrew and other mammalians highly support its close affinity to primates. By characterizing key factors and signalling pathways in nervous and immune systems, we demonstrate that tree shrews possess both shared common and unique features, and provide a genetic basis for the use of this animal as a potential model for biomedical research.
authors: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China.
authors: Yu
authors: Y
authors: Fan
authors: Zhi-Yong
authors: ZY
authors: Huang
authors: Chang-Chang
authors: CC
authors: Cao
authors: Ce-Shi
authors: CS
authors: Chen
authors: Yuan-Xin
authors: YX
authors: Chen
authors: Ding-Ding
authors: DD
authors: Fan
authors: Jing
authors: J
authors: He
authors: Hao-Long
authors: HL
authors: Hou
authors: Li
authors: L
authors: Hu
authors: Xin-Tian
authors: XT
authors: Hu
authors: Xuan-Ting
authors: XT
authors: Jiang
authors: Ren
authors: R
authors: Lai
authors: Yong-Shan
authors: YS
authors: Lang
authors: Bin
authors: B
authors: Liang
authors: Sheng-Guang
authors: SG
authors: Liao
authors: Dan
authors: D
authors: Mu
authors: Yuan-Ye
authors: YY
authors: Ma
authors: Yu-Yu
authors: YY
authors: Niu
authors: Xiao-Qing
authors: XQ
authors: Sun
authors: Jin-Quan
authors: JQ
authors: Xia
authors: Jin
authors: J
authors: Xiao
authors: Zhi-Qiang
authors: ZQ
authors: Xiong
authors: Lin
authors: L
authors: Xu
authors: Lan
authors: L
authors: Yang
authors: Yun
authors: Y
authors: Zhang
authors: Wei
authors: W
authors: Zhao
authors: Xu-Dong
authors: XD
authors: Zhao
authors: Yong-Tang
authors: YT
authors: Zheng
authors: Ju-Min
authors: JM
authors: Zhou
authors: Ya-Bing
authors: YB
authors: Zhu
authors: Guo-Jie
authors: GJ
authors: Zhang
authors: Jun
authors: J
authors: Wang
authors: Yong-Gang
authors: YG
authors: Yao
mesh_terms: D000818:Animals; D002681:China; D014644:Genetic Variation; D016678:Genome / Q000235:genetics*; D016174:Hepacivirus / Q000502:physiology; D006526:Hepatitis C / Q000235:genetics / Q000821:virology; D006801:Humans; D007107:Immune System / Q000378:metabolism; D008658:Inactivation, Metabolic / Q000235:genetics; D051379:Mice; D009420:Nervous System / Q000378:metabolism; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014417:Tupaia / Q000235:genetics* / Q000276:immunology
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