title: [Adoption of a biomarker in clinical practice: from bench to bedside].
abstract: Although numerous diagnostic and/or prognostic biomarkers are proposed in the literature, only a limited number of them are finally used in daily practice. The necessary steps to prove their clinical interest include: 1) an exhaustive clinical and statistical evaluation demonstrating not only the added value of the marker with regard to the existing validated tools but also the modification of the clinical practice induced by the knowledge of the result of the biomarker; 2) an evaluation of the pre-analytical, and analytical performances of its measure necessary to the reliability of the results; 3) an evaluation of its biological variation. These steps are a major prerequisite to an effective, reliable and optimal clinical interpretation of the biomarker, and should be validated for each routine biomarker.
authors: Laboratoire de biochimie, Hôpital Bichat-Claude Bernard, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France. monique.dehoux@bch.aphp.fr
authors: Monique
authors: M
authors: Dehoux
authors: Camille
authors: C
authors: Chenevier-Gobeaux
authors: Patrick
authors: P
authors: Ray
authors: Yann-Erick
authors: YE
authors: Claessens
authors: Guillaume
authors: G
authors: Lefevre
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D035843:Biomedical Research; D055317:Evidence-Based Practice; D006801:Humans; D019095:Point-of-Care Systems; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D015415:Biomarkers
keywords: biomarkers; evaluation; quality