title: The bis(indolyl)imidazole alkaloid nortopsentin a exhibits antiplasmodial activity.
abstract: A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This is the first report of nortopsentin A inhibiting parasite growth at the trophozoite stage at submicromolar 50% inhibitory concentrations (IC(50)).
authors: Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
authors: Stephenie
authors: S
authors: Alvarado
authors: Bracken F
authors: BF
authors: Roberts
authors: Amy E
authors: AE
authors: Wright
authors: Debopam
authors: D
authors: Chakrabarti
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D006801:Humans; D007093:Imidazoles / Q000302:isolation & purification / Q000494:pharmacology*; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011161:Porifera / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000302:isolation & purification / Q000494:pharmacology*; D053058:Trophozoites / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D007093:Imidazoles; D007211:Indoles; D054852:Small Molecule Libraries; C413129:topsentin A
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