title: Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women.
abstract: OBJECTIVE
  This study evaluated associations of various anthropometric measures of adiposity with a panel of inflammatory and oxidative stress markers in a relatively lean population of Chinese women.
  
  
  METHODS
  This analysis included 1,005 Chinese women aged 40-70 years. Plasma concentrations of inflammatory and oxidative stress markers were measured. Anthropometric measurements were taken by trained interviewers.
  
  
  RESULTS
  Body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) were all positively and linearly associated with the inflammatory markers, CRP, TNF-α, soluble TNF-receptor 1 (sTNF-R1), and IL-6. A significant positive association of these measures of adiposity with the oxidative stress marker F<formula>_2</formula>-IsoP-M, a metabolite of F<formula>_2</formula>-IsoPs, but with not F<formula>_2</formula>-IsoPs was found. Differences in biomarkers between extreme quartiles of anthropometric measurements varied widely, ranging from 9.7% for sTNF-R1 to 162.0% for CRP. For each specific biomarker, various anthropometric measurements exhibited similar ability to explain variations in the biomarker, with the biggest partial r<formula>^{2}</formula> (11%) observed for CRP.
  
  
  CONCLUSIONS
  This study suggests that both general adiposity (measured by BMI) and central adiposity (measured by WC and WHtR) are positively and similarly associated with various markers of inflammation and oxidative stress in relatively lean Chinese women. The metabolite F<formula>_2</formula>-IsoP-M of F<formula>_2</formula>-IsoPs may be a better marker of in vivo oxidative stress than its parent compounds.
authors: Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors: Sheng-Hui
authors: SH
authors: Wu
authors: Xiao-Ou
authors: XO
authors: Shu
authors: Wong-Ho
authors: WH
authors: Chow
authors: Yong-Bing
authors: YB
authors: Xiang
authors: Xianglan
authors: X
authors: Zhang
authors: Qiuyin
authors: Q
authors: Cai
authors: Hong-Lan
authors: HL
authors: Li
authors: Ginger
authors: G
authors: Milne
authors: Wanqing
authors: W
authors: Wen
authors: Bu-Tian
authors: BT
authors: Ji
authors: Nathaniel
authors: N
authors: Rothman
authors: Yu-Tang
authors: YT
authors: Gao
authors: Wei
authors: W
authors: Zheng
authors: Gong
authors: G
authors: Yang
mesh_terms: D050154:Adiposity; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers