title: Moderate oxidative stress and high antioxidative activity are associated with steatosis in Japanese males.
abstract: OBJECTIVE
  Steatosis is an increasingly common problem worldwide, accompanying increasing obesity. Recently, it has been suggested that oxidative stress plays an important role in development of fatty liver disease. We carried out an epidemiological study to clarify the role of oxidative stress and antioxidative activity in steatosis.
  
  
  METHODS
  This study was conducted with 184 male workers who had received their annual health checkup. Steatosis was confirmed using ultrasonography. Oxidative stress and antioxidative activity were assessed using the dROM test and the BAP test, respectively.
  
  
  RESULTS
  Steatosis was confirmed in 59 subjects (29.7%) by ultrasonography. There was no significant difference between cases and controls in BAP levels (2229.0 μmol/L vs. 2194.3μmol/L, p = 0.83). The steatosis group showed significantly lower dROM levels than the control group (332.7 U. CARR vs. 316.8 U. CARR, p < 0.05). In addition, we carried out logistic regression analysis to assess the combination between dROM levels and BAP levels. Subjects with high dROM levels and high BAP levels had 74% lower risk for steatosis than subjects with low dROM levels and high BAP levels.
  
  
  CONCLUSIONS
  Our results suggested that moderate oxidative stress and high antioxidative activity was associated with decreased steatosis risk in Japanese males.
authors: Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. imatoh@cis.fukuoka-u.ac.jp
authors: Takuya
authors: T
authors: Imatoh
authors: Seiichirou
authors: S
authors: Kamimura
authors: Shinichi
authors: S
authors: Tanihara
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D044466:Asian People; D002097:C-Reactive Protein / Q000378:metabolism; D005234:Fatty Liver / Q000097:blood / Q000473:pathology*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D002097:C-Reactive Protein
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