title: Probiotics and prebiotics: role in prevention of nosocomial sepsis in preterm infants.
abstract: Nosocomial sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. Prevention of sepsis especially in the preterm infants in the neonatal intensive care unit remains a major challenge. The gastrointestinal tract is an important source of potential pathogens causing nosocomial sepsis as the immature intestinal epithelium can permit translocation of bacteria and yeast. The intestinal tract and its microflora play an important role in the immunity. Altering the gut microflora has been extensively studied for immunomodulation in preterm infants. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Probiotics have been used for prevention and treatment of various medical conditions in children and adults. Studies on probiotics in premature infants have focused on normalizing intestinal flora, improvement in feeding intolerance, prevention of necrotizing enterocolitis and sepsis. In this paper, we discuss the intestinal bacterial colonization pattern; the rational for probiotics and prebiotic therapy with special focus on the prevention of nosocomial sepsis in preterm infants.
authors: Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary, AB, Canada T1N 1N4.
authors: Vrinda
authors: V
authors: Nair
authors: Amuchou S
authors: AS
authors: Soraisham
references: Lancet. 2006 Oct 7;368(9543):1271-83
references: 17027734
references: Clin Nutr. 2012 Feb;31(1):6-15
references: 21996513
references: J Pediatr Gastroenterol Nutr. 2004 Apr;38(4):389-91
references: 15085016
references: Pediatrics. 2012 Apr;129(4):e1085-93
references: 22451712
references: Clin Nutr. 2009 Jun;28(3):237-42
references: 19359074
references: Arch Dis Child Fetal Neonatal Ed. 1999 May;80(3):F167-73
references: 10212075
references: Pediatrics. 2010 Dec;126(6):1217-31
references: 21115585
references: BMB Rep. 2012 Aug;45(8):433-41
references: 22917027
references: Pediatrics. 2011 Aug;128(2):e348-57
references: 21768312
references: Pediatrics. 2010 May;125(5):921-30
references: 20403939
references: JAMA. 2004 Nov 17;292(19):2357-65
references: 15547163
references: Clin Infect Dis. 2006 Jun 15;42(12):1735-42
references: 16705580
references: N Engl J Med. 2011 Jan 20;364(3):255-64
references: 21247316
references: Eur J Clin Nutr. 2011 Apr;65(4):434-9
references: 21245887
references: Cochrane Database Syst Rev. 2011 Mar 16;(3):CD005496
references: 21412889
references: Clin Perinatol. 2004 Sep;31(3):489-500
references: 15325534
references: J Pediatr. 2005 Aug;147(2):192-6
references: 16126048
references: Arch Dis Child Fetal Neonatal Ed. 2002 May;86(3):F178-81
references: 11978748
references: Adv Pediatr. 1999;46:353-82
references: 10645469
references: Pak J Biol Sci. 2010 Mar 15;13(6):253-62
references: 20506712
references: J Perinatol. 2011 Jan;31(1):63-9
references: 20410904
references: J Med Microbiol. 1982 Nov;15(4):519-29
references: 6816935
references: J Pediatr Gastroenterol Nutr. 2009 Aug;49(2):258-61
references: 19561548
references: Pediatrics. 2002 Aug;110(2 Pt 1):285-91
references: 12165580
references: Pediatrics. 2005 Jan;115(1):1-4
references: 15629973
references: J Pediatr. 2010 Mar;156(3):393-6
references: 19914635
references: J Pediatr. 2010 Apr;156(4):679-81
references: 20303445
references: Biol Neonate. 2002 Aug;82(2):103-8
references: 12169832
references: Early Hum Dev. 2011 Mar;87 Suppl 1:S31-3
references: 21251768
references: Early Hum Dev. 2003 Nov;74(2):89-96
references: 14580749
references: J Pediatr Surg. 2012 Jan;47(1):241-8
references: 22244424
references: Curr Opin Pediatr. 2006 Apr;18(2):101-6
references: 16601486
references: J Nutr. 2000 Feb;130(2S Suppl):432S-436S
references: 10721921
references: Arch Dis Child Fetal Neonatal Ed. 2013 Jan;98(1):F5-9
references: 22556209
references: Int J Pediatr. 2011;2011:712150
references: 22164179
references: Arch Dis Child Fetal Neonatal Ed. 1997 Mar;76(2):F101-7
references: 9135288
references: Pediatrics. 2008 Oct;122(4):693-700
references: 18829790
references: Am J Clin Nutr. 2011 Jan;93(1):81-6
references: 20980486
references: Early Hum Dev. 2007 May;83(5):335-9
references: 16978805
references: Neonatology. 2010;98(2):156-63
references: 20234140
references: J Pediatr Gastroenterol Nutr. 2004 Apr;38(4):457-8
references: 15085028
references: Curr Opin Infect Dis. 2006 Jun;19(3):290-7
references: 16645492
references: Am J Health Syst Pharm. 2010 Mar 15;67(6):449-58
references: 20208051
references: J Nutr. 1995 Jun;125(6):1401-12
references: 7782892
references: J Perinatol. 2004 Jun;24(6):382-8
references: 15116140
references: Pediatrics. 2005 Jan;115(1):178-81
references: 15629999
references: Am J Clin Nutr. 2009 Jun;89(6):1828-35
references: 19369375
references: Am J Perinatol. 2012 Sep;29(8):579-86
references: 22566113
references: Lancet. 2003 May 31;361(9372):1869-71
references: 12788576
references: J Pediatr Gastroenterol Nutr. 2010 Jan;50(1):85-91
references: 19881390
references: J Pediatr Gastroenterol Nutr. 2007 Nov;45(5):569-76
references: 18030235
references: Arch Dis Child Fetal Neonatal Ed. 2012 May;97(3):F217-8
references: 22058179
references: J Pediatr Gastroenterol Nutr. 1999 Jan;28(1):19-25
references: 9890463
references: Lancet. 2007 May 12;369(9573):1614-20
references: 17499603
references: Early Hum Dev. 2007 Sep;83(9):575-9
references: 17229535
references: Acta Paediatr. 2010 Aug;99(8):1135-8
references: 20219023
references: J Trop Pediatr. 2009 Apr;55(2):128-31
references: 18842610
references: BMC Infect Dis. 2011 Aug 04;11:210
references: 21816056
references: Semin Perinatol. 2008 Apr;32(2):127-37
references: 18346537
references: Clin Microbiol Infect. 2011 Oct;17(10):1589-92
references: 21848974
references: J Matern Fetal Neonatal Med. 2011 Oct;24 Suppl 2:28-30
references: 21749301
references: Int J Infect Dis. 1999 Summer;3(4):197-202
references: 10575148
references: Mycoses. 2011 Sep;54(5):e643-6
references: 21672040
references: Acta Paediatr. 2006 Jul;95(7):843-8
references: 16801182
references: Arch Dis Child. 1993 Nov;69(5 Spec No):483-7
references: 8285750