title: Star-shaped polymer consisting of a porphyrin core and poly(L-lysine) dendron arms: synthesis, drug delivery, and in vitro chemo/photodynamic therapy.
abstract: A novel star-shaped polymer, porphyrin-poly(L-lysine) dendrons (PP-PLLD), is synthesized by the click reaction between azido-modified porphyrin and propargyl focal point poly(L-lysine) dendrons. Its chemical structure is characterized by (1) H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography (GPC) is analyses etc. Due to its amphiphilic property, the obtained PP-PLLD has a low critical micelle concentration in an aqueous solution, and can load doxorubicin (DOX) with a loading amount of 64 μg mg(-1) . By in vitro toxicity assay, PP-PLLD has no dark cytotoxicity but has significant phototoxicity. Moreover, DOX-loaded PP-PLLD shows a higher cytotoxicity under the light condition than PP-PLLD or DOX alone, suggesting PP-PLLD has a potential application in combined photodynamic therapy and chemotherapy.
authors: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, PR China.
authors: Dong
authors: D
authors: Ma
authors: Zong-Hua
authors: ZH
authors: Liu
authors: Qian-Qian
authors: QQ
authors: Zheng
authors: Xiao-Yan
authors: XY
authors: Zhou
authors: Yi
authors: Y
authors: Zhang
authors: Yun-Feng
authors: YF
authors: Shi
authors: Jian-Tao
authors: JT
authors: Lin
authors: Wei
authors: W
authors: Xue
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D057930:Click Chemistry; D050091:Dendrimers / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000494:pharmacology; D004339:Drug Compounding; D006801:Humans; D008027:Light; D015394:Molecular Structure; D010778:Photochemotherapy; D011107:Polylysine / Q000737:chemistry*; D011166:Porphyrins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D050091:Dendrimers; D004337:Drug Carriers; D011166:Porphyrins; D011107:Polylysine; D004317:Doxorubicin