title: Homologous involvement of striatum and prefrontal cortex in rodent and human water maze learning.
abstract: The multiple memory systems hypothesis posits that dorsal striatum and hippocampus are central nodes in independent memory systems, supporting response-based and place-based learning, respectively. Although our understanding of the function of hippocampus within this framework is relatively well established, the contribution of dorsal striatum is less clear. This in part seems to be due to the heterogeneous nature of dorsal striatum, which receives extensive topographically organized projections from higher cortical areas. Here we quantified neural activity in the intact brain while mice and humans acquired analogous versions of the Morris water maze. We found that dorsomedial striatum and medial prefrontal cortex support the initial acquisition of what is typically considered a hippocampus-dependent spatial learning task. We suggest that the circuit involving dorsomedial striatum and medial prefrontal cortex identified here plays a more task-independent role in early learning than currently thought. Furthermore, our results demonstrate that dorsomedial and dorsolateral striatum serve fundamentally different roles during place learning. The remarkably high degree of anatomical overlap in brain function between mouse and human observed in our study emphasizes the extent of convergence achievable with a well-matched multilevel approach.
authors: Laboratory of Movement Control and Neuroplasticity, KU Leuven, 3000 Leuven, Belgium.
authors: Daniel G
authors: DG
authors: Woolley
authors: Annelies
authors: A
authors: Laeremans
authors: Ilse
authors: I
authors: Gantois
authors: Dante
authors: D
authors: Mantini
authors: Ben
authors: B
authors: Vermaercke
authors: Hans P
authors: HP
authors: Op de Beeck
authors: Stephan P
authors: SP
authors: Swinnen
authors: Nicole
authors: N
authors: Wenderoth
authors: Lutgarde
authors: L
authors: Arckens
authors: Rudi
authors: R
authors: D'Hooge
mesh_terms: D000328:Adult; D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D018782:Maze Learning; D051379:Mice; D008810:Mice, Inbred C57BL; D017397:Prefrontal Cortex / Q000502:physiology*; D055815:Young Adult
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