title: Acute cerebral microbleeds in refractory status epilepticus.
abstract: Cerebral microbleeds (CMBs) are commonly found in patients with stroke and cerebral amyloid angiopathy. However, there have been no reports of CMBs or their acute appearance in patients with status epilepticus. Herein we describe two patients with refractory status epilepticus of uncertain origin. Both patients were previously healthy, and their initial imaging showed no underlying CMBs. One patient's follow-up susceptibility-weighted imaging 29 days after initial imaging showed 63 new CMBs. The other patient's follow-up susceptibility-weighted imaging 41 days after initial imaging showed 14 new CMBs. Multimodal neuromonitoring revealed increase in lactate-pyruvate ratio, decrease in partial brain tissue oxygen tension, increase in pressure reactivity index, and fluctuations of blood pressure and cerebral perfusion pressure. This report demonstrates that multiple new CMBs may develop in patients with refractory status epilepticus (SE).
authors: Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
authors: Sang-Beom
authors: SB
authors: Jeon
authors: Gunjan
authors: G
authors: Parikh
authors: H Alex
authors: HA
authors: Choi
authors: Kiwon
authors: K
authors: Lee
authors: Jong Hwan
authors: JH
authors: Lee
authors: J Michael
authors: JM
authors: Schmidt
authors: Neeraj
authors: N
authors: Badjatia
authors: Stephan A
authors: SA
authors: Mayer
authors: Jan
authors: J
authors: Claassen
mesh_terms: D000328:Adult; D002543:Cerebral Hemorrhage / Q000209:etiology*; D059345:Cerebral Small Vessel Diseases / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013226:Status Epilepticus / Q000150:complications*