title: Immunotherapeutic strategies to target prognostic and predictive markers of cancer.
abstract: Throughout the last century medical advances in cancer treatment in the fields of surgery, radiation therapy and chemotherapy have greatly impacted patients' survival rates. Nevertheless, cancer remains a significant cause of mortality, with an estimated 7.6 million deaths worldwide in 2008, reflecting the inability of existing therapies to effectively cure disease. The emergence of vaccines and their successes in preventing the spread of infectious diseases has demonstrated the unique specificity and therapeutic potential of the immune system. This potential has driven the development of novel cancer immunotherapeutics. This review focuses on the current status of the use of immunologic effectors to target known biomarkers in cancer.
authors: Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA.
authors: Michael S
authors: MS
authors: Magee
authors: Adam E
authors: AE
authors: Snook
authors: Glen P
authors: GP
authors: Marszalowicz
authors: Scott A
authors: SA
authors: Waldman
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D007167:Immunotherapy; D000922:Immunotoxins / Q000627:therapeutic use; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D019496:Cancer Vaccines; D000922:Immunotoxins
references: Nat Rev Immunol. 2012 Mar 22;12(4):269-81
references: 22437939
references: Semin Cancer Biol. 1999 Apr;9(2):67-81
references: 10202129
references: Gastroenterology. 1994 Dec;107(6):1653-61
references: 7958675
references: Proc Natl Acad Sci U S A. 1980 Sep;77(9):5419-23
references: 6968912
references: JAMA. 2009 Feb 18;301(7):745-52
references: 19224751
references: Science. 2011 Mar 25;331(6024):1565-70
references: 21436444
references: Dis Colon Rectum. 1998 Mar;41(3):310-5
references: 9514425
references: Clin Pharmacol Ther. 2007 Oct;82(4):441-7
references: 17687268
references: Nat Med. 2000 Apr;6(4):443-6
references: 10742152
references: Biochem Biophys Res Commun. 2000 Jun 24;273(1):225-30
references: 10873591
references: J Immunol. 2011 Jan 15;186(2):685-96
references: 21149604
references: Mol Cancer Ther. 2010 Oct;9(10):2689-99
references: 20937594
references: Oncologist. 2009 Nov;14(11):1131-8
references: 19897538
references: J Clin Oncol. 2005 Apr 1;23(10):2346-57
references: 15800326
references: Hum Pathol. 2005 Feb;36(2):170-9
references: 15754294
references: J Natl Cancer Inst. 1995 Jul 5;87(13):982-90
references: 7629885
references: Pharmacol Rev. 2000 Sep;52(3):375-414
references: 10977868
references: Clin Cancer Res. 1999 Sep;5(9):2330-7
references: 10499601
references: Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14827-32
references: 8962140
references: J Clin Invest. 1938 Jul;17(4):473-8
references: 16694594
references: N Engl J Med. 2004 Jun 3;350(23):2335-42
references: 15175435
references: J Clin Oncol. 2011 Mar 1;29(7):917-24
references: 21282551
references: N Engl J Med. 2010 Aug 19;363(8):711-23
references: 20525992
references: J Immunother. 2006 May-Jun;29(3):233-40
references: 16699366
references: Mol Ther. 2010 Feb;18(2):413-20
references: 19773745
references: Mol Ther. 2011 Mar;19(3):620-6
references: 21157437
references: Sci Transl Med. 2011 Aug 10;3(95):95ra73
references: 21832238
references: Cancer Epidemiol Biomarkers Prev. 1998 Jun;7(6):505-14
references: 9641495
references: J Clin Oncol. 2005 Feb 10;23(5):1011-27
references: 15585754
references: Dev Biol. 1999 Aug 15;212(2):307-22
references: 10433823
references: Curr Gene Ther. 2010 Apr;10(2):77-90
references: 20222863
references: Clin Cancer Res. 2002 Sep;8(9):2782-7
references: 12231517
references: N Engl J Med. 2012 Jun 28;366(26):2443-54
references: 22658127
references: Clin Cancer Res. 2007 Feb 15;13(4):1098-106
references: 17317817
references: Clin Cancer Res. 2000 Jan;6(1):34-41
references: 10656429
references: Cytometry A. 2004 Feb;57(2):86-93
references: 14750129
references: Clin Pharmacol Ther. 2007 Dec;82(6):734-9
references: 17898707
references: Int J Oncol. 2004 Apr;24(4):909-17
references: 15010829
references: Cancer Res. 2006 Apr 15;66(8):3992-5
references: 16618717
references: Int J Mol Med. 2002 Sep;10(3):307-10
references: 12165805
references: J Control Release. 2001 Jul 6;74(1-3):295-302
references: 11489509
references: Mol Ther. 2011 Apr;19(4):751-9
references: 21285960
references: Mol Ther. 2010 Apr;18(4):843-51
references: 20179677
references: Kidney Int. 2004 Jan;65(1):40-53
references: 14675035
references: N Engl J Med. 2008 Mar 13;358(11):1129-36
references: 18337603
references: J Immunol. 2006 Dec 15;177(12):8822-34
references: 17142785
references: Cancer Gene Ther. 2012 Dec;19(12):818-21
references: 23059871
references: Clin Cancer Res. 2012 Mar 15;18(6):1672-83
references: 22291136
references: Cell. 2000 Oct 13;103(2):211-25
references: 11057895
references: Cancer Res. 1993 Jan 15;53(2):340-7
references: 8417828
references: Blood. 2009 Jul 16;114(3):535-46
references: 19451549
references: Clin Cancer Res. 2011 Jul 15;17(14):4719-30
references: 21610146
references: Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3360-5
references: 19211796
references: Adv Cancer Res. 2000;78:31-101
references: 10547668
references: Clin Cancer Res. 2001 May;7(5):1181-91
references: 11350882
references: Bull Cancer. 2010 Dec;97(12):1441-52
references: 21220223
references: J Clin Oncol. 2010 Mar 1;28(7):1099-105
references: 20100959
references: Blood. 2012 Apr 26;119(17):3940-50
references: 22308288
references: Cancer Invest. 2007 Feb;25(1):67-77
references: 17364560
references: Target Oncol. 2010 Dec;5(4):257-67
references: 20842461
references: J Natl Cancer Inst. 2012 Apr 18;104(8):599-613
references: 22395641
references: N Engl J Med. 2008 May 8;358(19):2066-7
references: 18463385
references: Science. 1970 Jul 3;169(3940):68-70
references: 4986716
references: Mol Immunol. 2012 Jul;51(3-4):263-72
references: 22503210
references: Blood. 2012 Jun 14;119(24):5678-87
references: 22538857
references: Bosn J Basic Med Sci. 2009 Oct;9 Suppl 1:17-20
references: 19912113
references: J Immunother. 2008 Jun;31(5):500-5
references: 18463534
references: J Clin Oncol. 2001 Oct 1;19(19):3951-9
references: 11579116
references: Expert Opin Pharmacother. 2006 Aug;7(11):1469-74
references: 16859430
references: J Clin Oncol. 2001 Jul 1;19(13):3267-79
references: 11432895
references: J Clin Oncol. 2002 Feb 1;20(3):719-26
references: 11821453
references: Blood. 2011 Dec 1;118(23):6050-6
references: 21984804
references: N Engl J Med. 1987 Oct 8;317(15):909-16
references: 2442609
references: Oncoimmunology. 2012 Jul 1;1(4):407-408
references: 22754758
references: J Immunother. 1998 Jan;21(1):27-31
references: 9456433
references: J Natl Cancer Inst. 1988 Dec 21;80(20):1605-11
references: 3193478
references: J Immunother. 2010 Oct;33(8):780-8
references: 20842059
references: Int J Cancer. 1998 Feb 9;75(4):517-24
references: 9466650
references: Sci Transl Med. 2012 Mar 28;4(127):127ps8
references: 22461638
references: J Natl Cancer Inst. 2008 Jul 2;100(13):950-61
references: 18577748
references: J Clin Oncol. 2005 Feb 1;23(4):720-31
references: 15613691
references: J Transl Med. 2012 May 28;10:108
references: 22640522
references: Blood. 2012 Mar 22;119(12):2709-20
references: 22160384
references: N Engl J Med. 1971 Nov 18;285(21):1182-6
references: 4938153
references: Nat Rev Immunol. 2010 Aug;10(8):580-93
references: 20651745
references: Clin Cancer Res. 2011 Jul 1;17(13):4550-7
references: 21498393
references: Tissue Antigens. 2009 Oct;74(4):277-89
references: 19775368
references: Colorectal Dis. 2007 Jul;9(6):527-31
references: 17573747
references: J Clin Oncol. 2000 Dec 1;18(23):3964-73
references: 11099326
references: Clin Cancer Res. 2000 Jun;6(6):2219-28
references: 10873071
references: J Urol. 1987 Jun;137(6):1091-103
references: 3295298
references: Nat Med. 2001 May;7(5):548-52
references: 11329054
references: N Engl J Med. 2012 Nov 8;367(19):1783-91
references: 23020162
references: N Engl J Med. 2011 May 19;364(20):1897-908
references: 21526923
references: Nat Rev Cancer. 2012 Mar 22;12(4):252-64
references: 22437870
references: J Clin Oncol. 1998 Aug;16(8):2632-40
references: 9704713
references: Blood. 2011 Apr 21;117(16):4304-14
references: 21304103
references: Science. 2011 Jul 8;333(6039):143-4
references: 21737712
references: N Engl J Med. 2010 Jul 29;363(5):411-22
references: 20818862
references: J Cancer. 2011;2:378-82
references: 21750689
references: Expert Rev Mol Diagn. 2005 Sep;5(5):701-13
references: 16149873
references: Ann Intern Med. 1999 Dec 7;131(11):805-12
references: 10610624
references: Blood. 2009 Jun 18;113(25):6392-402
references: 19377047
references: Biomark Med. 2011 Jun;5(3):307-18
references: 21657840
references: Cancer Res. 2011 Sep 1;71(17):5697-706
references: 21742772
references: J Clin Invest. 2011 Dec;121(12):4746-57
references: 22056381
references: J Exp Med. 1965 Sep 1;122(3):467-81
references: 4953873
references: J Clin Oncol. 2008 Nov 10;26(32):5233-9
references: 18809613
references: J Clin Oncol. 2006 May 1;24(13):e20-2
references: 16648493
references: Blood. 2010 Nov 18;116(20):4099-102
references: 20668228
references: Adv Cancer Res. 2006;95:1-30
references: 16860654
references: Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6106-15
references: 17062687
references: J Clin Oncol. 2010 Apr 20;28(12):2085-93
references: 20308665
references: Eur Urol. 2010 Jul;58(1):75-83
references: 20359812
references: Cancer Sci. 2009 Nov;100(11):2014-21
references: 19719775
references: Nature. 1965 Nov 20;208(5012):795-6
references: 4223737
references: Cancer Res. 1993 Sep 1;53(17):3930-4
references: 8358720
references: Nat Rev Clin Oncol. 2011 Aug 02;8(10):577-85
references: 21808266
references: J Exp Med. 1995 Jan 1;181(1):399-404
references: 7528775
references: J Transl Med. 2012 Aug 03;10:157
references: 22863016
references: Gene Ther. 2013 May;20(5):575-80
references: 22972494
references: Nat Med. 2003 Jun;9(6):653-60
references: 12778163