title: Semiautomatic and rapid quantification of heartbeat parameters in Drosophila using optical coherence tomography imaging.
abstract: We report a semiautomatic algorithm that is specialized for rapid analysis of beat-to-beat contraction-relaxation parameters of the heart in Drosophila. The presented algorithm adapts the general graph theoretical image segmentation algorithm and a histogram-based thresholding algorithm, which can measure many cardiac parameters, including heart rate, heart period, diastolic and systolic intervals, and end-diastolic and end-systolic areas. Additionally, dynamic cardiac functions, such as arrhythmia index and percent fractional shortening, can be automatically calculated for all the recorded heartbeats over significant periods of time.
authors: National Taiwan Normal University, Institute of Electro-Optical Science and Technology, Tingchow Road, Sec. 4, 88, Taipei 116, Taiwan.
authors: Shou-Yuan
authors: SY
authors: Guo
authors: Fang-Tsu
authors: FT
authors: Liao
authors: Ming-Tsan
authors: MT
authors: Su
authors: Cheng-Yi
authors: CY
authors: Chang
authors: Hong-Ren
authors: HR
authors: Su
authors: Jyun-Cin
authors: JC
authors: Huang
authors: Wen-Chuan
authors: WC
authors: Kuo
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D003971:Diastole; D004331:Drosophila melanogaster / Q000502:physiology*; D006339:Heart Rate; D008297:Male; D023421:Models, Animal; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D055620:Optical Phenomena; D013599:Systole; D041623:Tomography, Optical Coherence / Q000706:statistics & numerical data*