title: Clinical implications of microRNAs in human glioblastoma.
abstract: Glioblastoma (GBM) is one of the most common and dismal brain tumors in adults. Further elucidation of the molecular pathogenesis of GBM is mandatory to improve the overall survival of patients. A novel small non-coding RNA molecule, microRNA (miRNA), appears to represent one of the most attractive target molecules contributing to the pathogenesis of various types of tumors. Recent global analyses have revealed that several miRNAs are clinically implicated in GBM, with some reports indicating the association of miRNA dysregulation with acquired temozolomide (TMZ) resistance. More recent studies have revealed that miRNAs could play a role in cancer stem cell (CSC) properties, contributing to treatment resistance. In addition, greater impact might be expected from miRNA-targeted therapies based on tumor-derived exosomes that contain numerous functional miRNAs, which could be transferred between tumor cells and surrounding structures. Tumor-derived miRNAs are now considered to be a novel molecular mechanism promoting the progression of GBM. Establishment of miRNA-targeted therapies based on miRNA dysregulation of CSCs could provide effective therapeutic strategies for TMZ-resistant GBM. Recent progress has revealed that miRNAs are not only putative biological markers for diagnosis, but also one of the most promising targets for GBM treatment. Here in, we summarize the translational aspects of miRNAs in the diagnosis and treatment of GBM.
authors: Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University Fukuoka, Japan.
authors: Masahiro
authors: M
authors: Mizoguchi
authors: Yanlei
authors: Y
authors: Guan
authors: Koji
authors: K
authors: Yoshimoto
authors: Nobuhiro
authors: N
authors: Hata
authors: Toshiyuki
authors: T
authors: Amano
authors: Akira
authors: A
authors: Nakamizo
authors: Tomio
authors: T
authors: Sasaki
keywords: exosome; glioblastoma; microRNA; temozolomide
references: Nature. 2006 Dec 7;444(7120):756-60
references: 17051156
references: Cancer J. 2012 Jan-Feb;18(1):40-4
references: 22290256
references: PLoS One. 2012;7(3):e33844
references: 22479456
references: Brain Tumor Pathol. 2011 Jul;28(3):209-14
references: 21618027
references: Cancer Res. 2011 May 1;71(9):3387-99
references: 21385897
references: Brain Pathol. 2010 May;20(3):539-50
references: 19775293
references: Cancer Res. 2009 Oct 1;69(19):7569-76
references: 19773441
references: Cancer Res. 2008 Nov 15;68(22):9125-30
references: 19010882
references: Genome Biol. 2009;10(6):R64
references: 19531210
references: Cancer Cell. 2010 Jan 19;17(1):98-110
references: 20129251
references: Int J Cancer. 2009 Sep 15;125(6):1407-13
references: 19536818
references: Biochem Biophys Res Commun. 2005 Sep 9;334(4):1351-8
references: 16039986
references: Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004
references: 14973191
references: Cancer Discov. 2012 Aug;2(8):736-49
references: 22750848
references: PLoS One. 2011 Mar 31;6(3):e17438
references: 21483847
references: Mod Pathol. 2010 Oct;23(10):1404-17
references: 20711171
references: BMC Genomics. 2009 Aug 28;10:407
references: 19715577
references: J Mol Neurosci. 2012 Jun;47(2):346-56
references: 22528454
references: DNA Repair (Amst). 2010 Nov 10;9(11):1170-5
references: 20869334
references: Nat Biotechnol. 2011 Apr;29(4):341-5
references: 21423189
references: Neuro Oncol. 2012 Sep;14(9):1153-62
references: 22844109
references: PLoS One. 2010 Jul 01;5(7):e11397
references: 20617180
references: Cancer Res. 2007 Dec 1;67(23):11111-6
references: 18056433
references: J Cell Mol Med. 2011 Aug;15(8):1636-44
references: 21435175
references: Brain Res. 2010 Sep 17;1352:255-64
references: 20633539
references: J Neurosci. 2009 Dec 2;29(48):15161-8
references: 19955368
references: BMC Med. 2008 Jun 24;6:14
references: 18577219
references: Radiother Oncol. 2011 Oct;101(1):171-6
references: 21676478
references: PLoS One. 2011 Feb 16;6(2):e14681
references: 21358821
references: Cancer Res. 2010 Aug 1;70(15):6303-12
references: 20647323
references: Lancet Oncol. 2009 May;10(5):459-66
references: 19269895
references: Radiat Oncol. 2011 Mar 31;6:29
references: 21453501
references: PLoS One. 2012;7(6):e38096
references: 22723849
references: Glia. 2011 Aug;59(8):1190-9
references: 21446051
references: Cell Cycle. 2010 Mar 15;9(6):1031-6
references: 20190569
references: Cancer Lett. 2010 Oct 28;296(2):241-8
references: 20444541
references: Nat Cell Biol. 2007 Jun;9(6):654-9
references: 17486113
references: Nature. 2005 Jun 9;435(7043):834-8
references: 15944708
references: Cell. 2009 Jan 23;136(2):215-33
references: 19167326
references: Cancer Res. 2008 May 15;68(10):3566-72
references: 18483236
references: Cancer Cell. 2012 Mar 20;21(3):283-96
references: 22439924
references: Nat Rev Genet. 2008 Feb;9(2):102-14
references: 18197166
references: Cancer Res. 2007 Mar 15;67(6):2456-68
references: 17363563
references: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9
references: 12434020
references: Nature. 2004 Sep 16;431(7006):350-5
references: 15372042
references: Nature. 2001 Nov 1;414(6859):105-11
references: 11689955
references: PLoS One. 2012;7(10):e47449
references: 23077620
references: Front Genet. 2012 Jul 02;3:120
references: 22783274
references: JAMA. 2007 May 2;297(17):1901-8
references: 17473300
references: Clin Cancer Res. 2010 Aug 15;16(16):4289-97
references: 20601442
references: Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2183-8
references: 20080666
references: Cancer Cell. 2006 Mar;9(3):157-73
references: 16530701
references: J Oncol. 2012;2012:732874
references: 22848219
references: Cancer Res. 2005 Jul 15;65(14):6029-33
references: 16024602
references: Oncogene. 2013 Feb 28;32(9):1155-63
references: 22580610
references: Cell. 2004 Jan 23;116(2):281-97
references: 14744438
references: Cancer Res. 2010 Nov 1;70(21):8259-63
references: 20841486
references: Nature. 2010 Sep 2;467(7311):86-90
references: 20693987
references: Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7
references: 21037258
references: Cancer Res. 2008 Oct 1;68(19):8164-72
references: 18829576
references: Oncol Rep. 2010 Apr;23(4):997-1003
references: 20204284
references: N Engl J Med. 2005 Mar 10;352(10):987-96
references: 15758009
references: Cancer J. 2012 Jan-Feb;18(1):89-99
references: 22290262