title: Molecular dynamics of the interaction of anionic surfactants with liposomes.
abstract: The time dependent molecular interactions of sodium dodecyl sulfate (SDS) with dipalmitoylphosphatidylcholine (DPPC) liposomes were studied using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy. In particular, the ATR spectra provided information on the dynamic amount of SDS incorporated and DPPC expelled in the DPPC structure along with structural information on the molecular nature of the SDS/DPPC assemblies. It was found that the uptake of SDS was always mirrored by the ejection of DPPC molecules from the liposomes and that the incorporation of SDS followed two routes; SDS intercalated into the DPPC liposomes and SDS was bound electrostatically to the charged surface of the DPPC liposome.
authors: Laboratory for Surface Science and Technology, Department of Chemistry, University of Maine, Orono, ME 04469, United States.
authors: Changfeng
authors: C
authors: Chen
authors: Cuihong
authors: C
authors: Jiang
authors: Carl P
authors: CP
authors: Tripp
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry* / Q000378:metabolism; D008081:Liposomes; D056004:Molecular Dynamics Simulation; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry* / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry* / Q000378:metabolism
chemical_list: D008081:Liposomes; D013501:Surface-Active Agents; D015060:1,2-Dipalmitoylphosphatidylcholine; D012967:Sodium Dodecyl Sulfate