title: Hemorrhagic stroke in young healthy male following use of sports supplement Jack3d.
abstract: A 26-year-old male was presented to a military treatment facility in Afghanistan shortly after taking a weight-lifting supplement called Jack3d with a severe headache and was subsequently found to have suffered a Dejerine-Roussy variant right thalamic hemorrhagic stroke. Jack3d active ingredients include geranamine, schizandrol A, caffeine, beta-alanine, creatine monohydrate, and L-arginine alpha-ketoglutarate. A literature search revealed case reports suggesting some of the constituent ingredients may predispose to stroke and hemorrhage and also revealed a substantial paucity of data existed regarding schizandrol A, a herb used in traditional eastern medicine. The product has no readily apparent disclaimer or warning regarding the risks or lack of data regarding the components. Jack3d is sold as a nutritional supplement and is therefore not subject to same FDA regulation and scrutiny that a pharmaceutical receives. The potential adverse effect was reported to the FDA via MedWatch in accordance with the recently passed Dietary Supplement and Nonprescription Drug Consumer Protection Act.
authors: Naval Undersea Medical Institute, Box 159 NAVSUBASE NLON, Groton, CT 06349, USA.
authors: Colin
authors: C
authors: Young
authors: Olamide
authors: O
authors: Oladipo
authors: Samuel
authors: S
authors: Frasier
authors: Robert
authors: R
authors: Putko
authors: Stacy
authors: S
authors: Chronister
authors: Mary
authors: M
authors: Marovich
mesh_terms: D000328:Adult; D000588:Amines / Q000009:adverse effects / Q000032:analysis; D019587:Dietary Supplements / Q000009:adverse effects*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008889:Military Personnel; D059409:Stroke, Lacunar / Q000139:chemically induced* / Q000175:diagnosis; D013566:Sympathomimetics / Q000009:adverse effects / Q000032:analysis; D013786:Thalamic Diseases / Q000139:chemically induced; D014057:Tomography, X-Ray Computed
chemical_list: C571979:1,3-dimethylamylamine; D000588:Amines; D013566:Sympathomimetics