title: Null genotype of glutathione S-transferase T1 contributes to increased risk of gastric cancer in Asian population.
abstract: Numerous studies were published to investigate the relationship between the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric cancer in Asians, but the conclusions from those studies were conflicting. To get a more precise estimation on the possible association, we performed a meta-analysis of published data. A comprehensive literature was conducted and 27 case-control studies with 14,905 individuals were finally included, involving a total of 6,270 cases and 8,635 controls. The strength of the association between GSTT1 polymorphism and gastric cancer risk was estimated by calculating the pooled odds ratio with its 95 % confidence interval (95 % CI). A meta-analysis of total 27 studies showed that GSTT1 null genotype was obviously associated with increased risk of gastric cancer in Asians (random effect odds ratio (OR) =1.29, 95 % CI 1.16-1.44, P OR<0.001). A subgroup analysis of 14 studies with large sample size also showed an obvious association between GSTT1 null genotype and increased risk of gastric cancer in Asians (fixed effect OR=1.14, 95 % CI 1.06-1.23, P OR=0.001). In conclusion, the meta-analysis suggests that null genotype of GSTT1 contributes to increased risk of gastric cancer in Asian population.
authors: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors: Wanli
authors: W
authors: Zhang
authors: Jing
authors: J
authors: Huang
authors: Gang
authors: G
authors: Peng
authors: Qian
authors: Q
authors: Ding
authors: Jing
authors: J
authors: Chen
authors: Yawei
authors: Y
authors: Hua
authors: Jun
authors: J
authors: Xue
mesh_terms: D001208:Asia / Q000453:epidemiology; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology*
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase
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