title: Sulfation of Aegle marmelos gum: synthesis, physico-chemical and functional characterization.
abstract: The present investigation was aimed at optimizing the conditions for preparing sulfated derivative of gum obtained from partially ripe fruits of Aegle marmelos. Elemental analysis, FTIR-ATR and NMR studies confirmed successful sulfation. The ratio of chlorosulfonic acid to pyridine exerted maximum influence on the degree of substitution followed by reaction temperature and reaction time. The sulfated derivative showed higher swelling in both acidic and alkaline pH as compared to unmodified gum. It also possessed higher negative zeta potential, higher viscosity, work of shear, firmness, consistency, cohesiveness and index of viscosity as compared to both unmodified gum as well as sodium alginate. Sulfated derivative was superior to unmodified gum and sodium alginate in terms of antimicrobial and anticoagulant activity. The sulfated sample appears to be a potential substitute over the unmodified gum sample and sodium alginate for modulating physicochemical properties of food and drug release dosage forms.
authors: Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India.
authors: Manish
authors: M
authors: Jindal
authors: Vikas
authors: V
authors: Rana
authors: Vineet
authors: V
authors: Kumar
authors: Ram S
authors: RS
authors: Singh
authors: John F
authors: JF
authors: Kennedy
authors: Ashok K
authors: AK
authors: Tiwary
mesh_terms: D045471:Aegle / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D055598:Chemical Phenomena; D060326:Chemistry Techniques, Synthetic; D005502:Food; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D012212:Rheology; D013431:Sulfates / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D011134:Polysaccharides; D013431:Sulfates