title: Peptide immunization elicits polyomavirus-specific MHC class ib-restricted CD8 T cells in MHC class ia allogeneic mice.
abstract: Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2(b) haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immunization with a peptide corresponding to a virus capsid-derived peptide presented by Q9 also elicits MHC class Ib-restricted MPyV-specific CD8 T cells in mice of H-2(s) and H-2(g7) strains. These findings support the concept that immunization with a single MHC class Ib-restricted peptide can expand CD8 T cells in MHC class Ia allogeneic hosts.
authors: Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
authors: Amelia R
authors: AR
authors: Hofstetter
authors: Brian D
authors: BD
authors: Evavold
authors: Aron E
authors: AE
authors: Lukacher
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D036022:Capsid Proteins / Q000276:immunology*; D005260:Female; D005838:Genotype; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D051379:Mice; D011120:Polyomavirus / Q000276:immunology*; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D036022:Capsid Proteins; D006183:H-2 Antigens; D022223:Vaccines, Subunit
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