title: [The effect of phospholipid hepatoprotectors on lipid peroxidation in liver and content of cytokines in the blood in experimental pathology caused by isoniazid].
abstract: The purpose--to investigate the influence of hepatoprotective agents of phospholipids'structure essentiale, eplir and its combinations with amber acid on rats liver functional state, lipoperoxidation and bioenergetics, also tumor necrosis factor-a and interleukin-10 blood content in experimental isoniazid intoxication. These agents demonstrated antioxidant action, decreased the common and indirect bilirubine, tumor necrosis factor-alpha blood content, aminotransferase and alkaline phosphatase activity, increased the interleukin-10 blood content. Isonoazid uncoupled the substrate oxidation with ADP phosphorylation and inhibited the respiratory activity of liver mitochondrions. Essentiale and eplir increased the coupling of oxidation with ATP synthesis, in combination with amber acid improved kinetic characteristics of liver mitochondrions.
authors: V V
authors: VV
authors: Udut
authors: A I
authors: AI
authors: Vengerovskiĭ
authors: V N
authors: VN
authors: Burkova
authors: O E
authors: OE
authors: Vaizova
authors: D A
authors: DA
authors: Korshunov
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000494:pharmacology; D001663:Bilirubin / Q000097:blood; D002338:Carotenoids / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D004338:Drug Combinations; D016753:Interleukin-10 / Q000097:blood*; D007538:Isoniazid / Q000009:adverse effects* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010743:Phospholipids / Q000494:pharmacology*; D051381:Rats; D000637:Transaminases / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D000975:Antioxidants; D000995:Antitubercular Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010743:Phospholipids; D014409:Tumor Necrosis Factor-alpha; C064845:eplir; C011246:essential 303 forte; D016753:Interleukin-10; D002338:Carotenoids; D000637:Transaminases; D000469:Alkaline Phosphatase; D001663:Bilirubin; D007538:Isoniazid