title: [p53 expression in the gastric mucosa of patients infected with Helicobacter pylori].
abstract: BACKGROUND
  Helicobacter pylori (Hp) is recognized as a type 1 carcinogen for gastric cancer associated with pre-neoplastic lesions (atrophy and intestinal metaplasia [IM]). Its relation with p53, which intervenes in the cell cycle, has had contradictory results.
  
  
  OBJECTIVE
  To analyze p53 expression in gastric mucosa and its relation with Hp infection.
  
  
  METHODS
  A 3-month prospective, observational, cross-sectional study was conducted. Patients that had no evidence of acute or clinically significant gastric pathology had biopsies taken according to the Sydney system at the Hospital Juárez de México and the histopathologic studies were done at the Hospital Español de México.
  
  
  RESULTS
  Hp prevalence was 32.7% in 104 patients. There were no cases of atrophy or dysplasia. A total of 91% of the infected patients were positive for p53. Of the non-infected patients, 14% were positive for p53 and 60% of them had IM. Of the IM patients, 75% presented with positive p53. Of the patients without IM, 31 presented with positive p53, and Hp was positive in 85% of them. There was association between Hp and p53 and between p53 and IM (P<.0001 and P<.0006, respectively).
  
  
  CONCLUSIONS
  Significant association was shown between Hp and p53 expression, even in patients with pre-neoplastic lesions that no longer presented with Hp. Given that the identification of pre-neoplastic lesions is important for the prevention of cancer, immunohistochemistry could benefit routine biopsy carried out during endoscopy for the detection of Hp, by identifying patients with expression of the important oncogene regulator, p53.
authors: Servicio de Endoscopia Gastrointestinal, Hospital General Regional No. 1 «Dr. Carlos MacGregor Sánchez Navarro», IMSS, México DF, México. gerar3d@yahoo.com
authors: G A
authors: GA
authors: Morales-Fuentes
authors: A
authors: A
authors: Zarate-Osorno
authors: E E
authors: EE
authors: Quiñónez-Urrego
authors: M
authors: M
authors: Antonio-Manrique
authors: C L
authors: CL
authors: Martínez-García
authors: P
authors: P
authors: Figueroa-Barojas
authors: Y
authors: Y
authors: Zamorano-Orozco
authors: S E
authors: SE
authors: Leal-Osuna
authors: C
authors: C
authors: Martínez-Camacho
authors: L A
authors: LA
authors: Mejía-Cuán
authors: C A
authors: CA
authors: Rivera-Nava
authors: X
authors: X
authors: Sánchez-Chávez
authors: M A
authors: MA
authors: Ramírez-Ramírez
mesh_terms: D000328:Adult; D001706:Biopsy; D003430:Cross-Sectional Studies; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D015870:Gene Expression / Q000235:genetics / Q000502:physiology*; D016158:Genes, p53 / Q000235:genetics / Q000502:physiology*; D016481:Helicobacter Infections / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D016159:Tumor Suppressor Protein p53