title: Stimulation of perforant path fibers induces LTP concurrently in amygdala and hippocampus in awake freely behaving rats.
abstract: Long-term potentiation (LTP) which has long been considered a cellular model for learning and memory is defined as a lasting enhancement in synaptic transmission efficacy. This cellular mechanism has been demonstrated reliably in the hippocampus and the amygdala-two limbic structures implicated in learning and memory. Earlier studies reported on the ability of cortical stimulation of the entorhinal cortex to induce LTP simultaneously in the two sites. However, to retain a stable baseline of comparison with the majority of the LTP literature, it is important to investigate the ability of fiber stimulation such as perforant path activation to induce LTP concurrently in both structures. Therefore, in this paper we report on concurrent LTP in the basolateral amygdala (BLA) and the dentate gyrus (DG) subfield of the hippocampus induced by theta burst stimulation of perforant path fibers in freely behaving Sprague-Dawley rats. Our results indicate that while perforant path-evoked potentials in both sites exhibit similar triphasic waveforms, the latency and amplitude of BLA responses were significantly shorter and smaller than those of DG. In addition, we observed no significant differences in either the peak level or the duration of LTP between DG and BLA.
authors: Neuroscience Program, Trinity College, Hartford, CT 06106, USA. harry.blaise@trincoll.edu
authors: J Harry
authors: JH
authors: Blaise
authors: Rachel A
authors: RA
authors: Hartman
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D019580:Perforant Pathway / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014851:Wakefulness / Q000502:physiology*
references: Neuroscience. 1997 Mar;77(2):445-59
references: 9472403
references: Hippocampus. 1999;9(3):277-87
references: 10401642
references: Prog Neuropsychopharmacol Biol Psychiatry. 2003 Dec;27(8):1213-23
references: 14659476
references: Pharmacol Ther. 1995;68(2):297-42
references: 8719972
references: Neurobiol Learn Mem. 2006 Sep;86(2):123-32
references: 16458544
references: Neurobiol Learn Mem. 1996 Nov;66(3):253-7
references: 8946419
references: Annu Rev Neurosci. 2000;23:649-711
references: 10845078
references: Neural Plast. 2008;2008:381243
references: 18769556
references: J Neurosci. 1990 May;10(5):1472-8
references: 2332791
references: J Neurosci. 2002 Nov 15;22(22):9912-21
references: 12427848
references: J Neurosci. 1995 Nov;15(11):7548-64
references: 7472506
references: Annu Rev Neurosci. 2004;27:1-28
references: 15217324
references: Curr Opin Neurobiol. 2001 Dec;11(6):752-6
references: 11741029
references: Exp Neurol. 1992 Jun;116(3):330-8
references: 1350255
references: Nature. 1993 Jan 7;361(6407):31-9
references: 8421494
references: Neuroreport. 2001 Mar 5;12(3):635-40
references: 11234779
references: Science. 1999 Sep 17;285(5435):1870-4
references: 10489359
references: Brain Res. 1998 Oct 19;808(2):134-40
references: 9767150
references: Brain Res. 1994 Nov 21;664(1-2):207-10
references: 7895029
references: Hippocampus. 2004;14(6):677-83
references: 15318326
references: Behav Neural Biol. 1992 Jan;57(1):2-36
references: 1567331
references: Brain Res. 1994 Dec 15;666(2):232-8
references: 7882033
references: Curr Opin Neurobiol. 1996 Apr;6(2):237-42
references: 8725966
references: Neurosci Lett. 1995 Aug 25;196(3):177-80
references: 7501277
references: Neuroscience. 2003;120(4):1125-35
references: 12927217
references: Prog Neurobiol. 2003 Aug;70(5):409-20
references: 14511699
references: Neurosci Res. 1995 May;22(2):203-7
references: 7566701
references: Hippocampus. 2006;16(1):35-42
references: 16200643
references: Prog Neurobiol. 1998 Jun;55(3):257-332
references: 9643556
references: Neuron. 2004 Sep 16;43(6):897-905
references: 15363399
references: Brain Res. 2008 Feb 8;1193:25-33
references: 18178177
references: Trends Cogn Sci. 2000 Jun;4(6):215-222
references: 10827444
references: Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10924-9
references: 11517323
references: J Physiol. 1973 Jul;232(2):331-56
references: 4727084
references: Amino Acids. 2007;32(3):305-15
references: 17048126
references: J Neurophysiol. 1978 May;41(3):716-32
references: 207830
references: Nat Rev Neurosci. 2006 Jan;7(1):54-64
references: 16371950
references: Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10718-23
references: 16020527
references: Neurobiol Learn Mem. 2002 Nov;78(3):539-52
references: 12559833
references: Annu Rev Neurosci. 2001;24:897-931
references: 11520922
references: Eur J Neurosci. 2004 Apr;19(7):1887-94
references: 15078562
references: Neuroscientist. 2003 Dec;9(6):463-74
references: 14678579
references: Trends Neurosci. 2002 Sep;25(9):456
references: 12183206
references: Trends Neurosci. 1998 Jul;21(7):294-9
references: 9683321
references: Annu Rev Neurosci. 2000;23:155-84
references: 10845062
references: Br J Anaesth. 1989 Mar;62(3):301-10
references: 2539171
references: Eur J Pharmacol. 2000 Sep 29;405(1-3):397-406
references: 11033344
references: Hippocampus. 1997;7(6):643-55
references: 9443060