title: Impact of menstrual and reproductive factors on breast cancer risk in Tunisia: a case-control study.
abstract: This report examined the relationship between menstrual and reproductive factors and breast cancer risk. The case-control study was conducted on 400 women with histological confirmed breast cancer operated during the 2006-2009 period at Farhat Hached University Hospital, Sousse, Tunisia, and 400 cancer-free controls, aged 25-75 years. The menstrual and reproductive history was assessed using a structured questionnaire. Odds ratios (ORs), 95 % confidence intervals (CI) and a full confounding assessment, included in this analysis, were derived using logistic regression. A positive family history of breast cancer was associated with a significantly increased risk of breast cancer (OR = 5.15, 95 % CI 1.48-17.94). Significant risk reduction was found with later age at menarche (P = 0.02). There was an insignificant increase in risk with later age at menopause (≥ 51 years; OR = 1.87), later age at first live birth (≥ 26 years; OR = 1.76) and nulliparous women compared to parous women (OR = 2.35). An insignificant decrease in risk was observed with increasing parity number (≥ 3 delivery; OR = 0.86). A significantly reduced risk of breast cancer was found for those women whose lifetime duration of breastfeeding was 73-108 months and for those who breastfed for ≥ 109 months (P = 0.00). Our findings suggest that age at menarche and breastfeeding history have great effects on breast cancer risk among Tunisian women.
authors: Department of Medical Oncology, CHU Farhat Hached, 4000 Sousse, Tunisia. awatefmsolly@gmail.com
authors: Awatef
authors: A
authors: Msolly
authors: Olfa
authors: O
authors: Gharbi
authors: Slim
authors: S
authors: Ben Ahmed
mesh_terms: D000328:Adult; D000368:Aged; D001942:Breast Feeding; D001943:Breast Neoplasms / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008572:Menarche; D008593:Menopause; D008875:Middle Aged; D010298:Parity; D011247:Pregnancy; D012307:Risk Factors; D014416:Tunisia / Q000453:epidemiology
references: Am J Epidemiol. 2000 Apr 1;151(7):715-22
references: 10752799
references: Am J Epidemiol. 2000 Dec 15;152(12):1129-35
references: 11130618
references: Am J Epidemiol. 2004 Apr 1;159(7):671-82
references: 15033645
references: Med Oncol. 2004;21(1):31-40
references: 15034211
references: JAMA. 2002 Jul 17;288(3):321-33
references: 12117397
references: Am J Epidemiol. 2008 Dec 15;168(12):1425-32
references: 18974083
references: Int J Cancer. 2003 Nov 20;107(4):647-51
references: 14520705
references: Ann Oncol. 1992 Sep;3(8):625-9
references: 1450044
references: Br J Cancer. 1997;75(5):752-6
references: 9043036
references: Stat Med. 1987 Jul-Aug;6(5):613-27
references: 3659671
references: Epidemiol Rev. 1993;15(1):36-47
references: 8405211
references: Epidemiol Rev. 1993;15(1):48-65
references: 8405212
references: Eur J Cancer Prev. 2007 Apr;16(2):116-23
references: 17297387
references: Cancer Epidemiol Biomarkers Prev. 2004 Aug;13(8):1296-301
references: 15298949
references: East Mediterr Health J. 2007 Nov-Dec;13(6):1265-73
references: 18341177
references: Cancer Causes Control. 2010 Jan;21(1):135-45
references: 19816778
references: Breast Cancer Res Treat. 2007 May;102(3):365-74
references: 17033925
references: Lancet. 1996 Jun 22;347(9017):1713-27
references: 8656904
references: Br J Cancer. 2001 Jun 1;84(11):1472-6
references: 11384096
references: Cancer. 1988 Oct 15;62(8):1625-31
references: 3167776
references: IARC Monogr Eval Carcinog Risks Hum. 2007;91:1-528
references: 18756632
references: Jpn J Cancer Res. 1995 Oct;86(10):910-5
references: 7493908
references: Am J Epidemiol. 1999 Jul 15;150(2):174-82
references: 10412962
references: Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3170-8
references: 18990759
references: Lancet. 1997 Oct 11;350(9084):1047-59
references: 10213546
references: Int J Cancer. 2000 Jul 15;87(2):295-300
references: 10861490
references: Int J Cancer Suppl. 1990;5:5-21
references: 2258266
references: Int J Cancer. 1999 Jan 18;80(2):231-6
references: 9935204
references: Nature. 1995 Dec 21-28;378(6559):789-92
references: 8524414
references: Am J Epidemiol. 1982 Jul;116(1):114-22
references: 7102647
references: Sante Publique. 2002 Sep;14(3):231-41
references: 12564048
references: Cancer. 1993 May 15;71(10):3185-8
references: 8490850
references: Prev Med. 2000 May;30(5):363-70
references: 10845745
references: Br J Cancer. 2002 Mar 4;86(5):723-7
references: 11875733
references: Science. 1994 Oct 7;266(5182):66-71
references: 7545954
references: Cancer Sci. 2005 Jan;96(1):57-62
references: 15649257
references: Int J Epidemiol. 1999 Jun;28(3):396-402
references: 10405840