title: Skeletal muscle aging and the mitochondrion.
abstract: Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed, skeletal muscle mitochondrial decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population.
authors: Mayo Clinic, Division of Endocrinology, 200 First Street SW, Joseph 5-194, Rochester, MN 55905, USA.
authors: Matthew L
authors: ML
authors: Johnson
authors: Matthew M
authors: MM
authors: Robinson
authors: K Sreekumaran
authors: KS
authors: Nair
mesh_terms: D000375:Aging; D000818:Animals; D006801:Humans; D008931:Mitochondria, Muscle / Q000201:enzymology / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000378:metabolism / Q000503:physiopathology; D063154:Mitochondrial Dynamics; D024101:Mitochondrial Proteins / Q000378:metabolism; D008954:Models, Biological; D009124:Muscle Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D055550:Protein Stability; D055948:Sarcopenia / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D024101:Mitochondrial Proteins; D009124:Muscle Proteins
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