title: Montmorillonite K-10 catalyzed green synthesis of 2,6-unsubstituted dihydropyridines as potential inhibitors of PDE4.
abstract: Montmorillonite K-10 mediated MCR of anilines, arylaldehydes and ethyl-3,3-diethoxypropionate in water afforded 2,6-unsubstituted dihydropyridines depending on the nature of anilines employed. A variety of dihydropyridines were prepared by using this green methodology in good yields and montmorillonite K-10 was found to be an inexpensive and reusable catalyst. The structure elaboration of a representative compound was carried out under Heck conditions. Some of the compounds synthesized showed significant inhibition of PDE4B when tested in vitro. Docking studies indicated that one of the ester moieties of these compounds played a key role in their interactions with the PDE4B protein.
authors: Custom Pharmaceutical Services, Dr. Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India.
authors: T Ram
authors: TR
authors: Reddy
authors: G Rajeshwar
authors: GR
authors: Reddy
authors: L Srinivasula
authors: LS
authors: Reddy
authors: Chandana Lakshmi T
authors: CL
authors: Meda
authors: Kishore V L
authors: KV
authors: Parsa
authors: K Shiva
authors: KS
authors: Kumar
authors: Y
authors: Y
authors: Lingappa
authors: Manojit
authors: M
authors: Pal
mesh_terms: D001546:Bentonite / Q000737:chemistry*; D002384:Catalysis; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism*; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D058988:Phosphodiesterase 4 Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004095:Dihydropyridines; D058988:Phosphodiesterase 4 Inhibitors; C503188:montmorillonite K-10; D001546:Bentonite; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517360:PDE4B protein, human