title: An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease.
abstract: Previous genome-wide association studies (GWAS) have revealed seven single nucleotide polymorphisms (SNPs) that affect lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity or levels in American and European individuals. A total of 290 coronary heart disease (CHD) patients, 198 non-CHD patients and 331 unrelated healthy volunteers were recruited for the present case-control study of Han Chinese. Four SNPs (rs964184 of ZNF259, rs7528419 of CELSR2 and rs7756935 and rs1805017 of PLA2G7) were shown to be significantly associated with CHD. The rs964184-G allele of the ZNF259 gene was identified as a risk factor of CHD in females (odds ratio (OR) =1.49, 95% confidence interval (CI) =1.00-2.22, P=0.05). The rs7528419-G allele of the CELSR2 gene was protective against CHD in males (OR=0.48, 95% CI=0.25-0.93, P=0.04). The other two alleles (rs7756935-C and rs1805017-A) of the PLA2G7 gene acted as protective factors against CHD in females (rs7756935-C: OR=0.59, 95% CI=0.35-1.00, P=0.05; rs1805017-A: OR=0.51, 95% CI=0.28-0.93, P=0.03). Moreover, rs1805017 of the PLA2G7 gene was associated with the severity of CHD only in females (r(2)=0.02, P=0.04). We identified four Lp-PLA(2)-associated SNPs significantly associated with CHD in a Han Chinese population. Specifically, rs7528419 was protective factor against CHD in males, while the other two SNPs (rs7756935 and rs1805017 of the PLA2G7 gene) were protective factors against CHD in females and rs964184 of the ZNF259 gene was regarded as a risk factor for CHD in females.
authors: School of Medicine, The Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315211;
authors: Limin
authors: L
authors: Xu
authors: Jianqing
authors: J
authors: Zhou
authors: Stephanie
authors: S
authors: Huang
authors: Yi
authors: Y
authors: Huang
authors: Yanping
authors: Y
authors: LE
authors: Danjie
authors: D
authors: Jiang
authors: Feiming
authors: F
authors: Wang
authors: Xi
authors: X
authors: Yang
authors: Weifeng
authors: W
authors: Xu
authors: Xiaoyan
authors: X
authors: Huang
authors: Changzheng
authors: C
authors: Dong
authors: Lina
authors: L
authors: Zhang
authors: Meng
authors: M
authors: Ye
authors: Jiangfang
authors: J
authors: Lian
authors: Shiwei
authors: S
authors: Duan
keywords: CELSR2; PLA2G7; ZNF259; coronary heart disease; lipoprotein-associated phospholipase A; single nucleotide polymorphism
references: PLoS One. 2011;6(11):e27481
references: 22110658
references: Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):854-60
references: 15681296
references: Mol Biol Rep. 2012 Jul;39(7):7365-72
references: 22311046
references: PLoS Genet. 2010 Sep 09;6(9):e1001094
references: 20838585
references: Lancet. 2005 Oct 15-21;366(9494):1407-9
references: 16226619
references: Mol Biol Rep. 2011 Aug;38(6):4089-99
references: 21107710
references: Atherosclerosis. 2011 Dec;219(2):737-42
references: 21889769
references: J Mol Med (Berl). 2008 Nov;86(11):1233-41
references: 18649068
references: PLoS One. 2012;7(3):e31930
references: 22403620
references: Mol Ecol Resour. 2010 May;10(3):564-7
references: 21565059
references: Curr Protoc Hum Genet. 2009 Jan;Chapter 2:Unit 2.12
references: 19170031
references: Harefuah. 2011 Feb;150(2):136-40, 205
references: 22164942
references: J Clin Endocrinol Metab. 2006 Sep;91(9):3382-8
references: 16684835
references: J Adv Nurs. 2005 Aug;51(4):382-95
references: 16086807
references: Cerebrovasc Dis. 2012;33(2):150-8
references: 22178747
references: Nat Genet. 2008 Feb;40(2):161-9
references: 18193043
references: Circulation. 2010 Jun 1;121(21):2284-93
references: 20479152
references: Lancet. 2008 Feb 9;371(9611):483-91
references: 18262040
references: J Biol Chem. 2009 Jul 24;284(30):19826-34
references: 19491399
references: Am J Cardiol. 2008 Jun 16;101(12A):34F-40F
references: 18549870
references: Circ Cardiovasc Genet. 2010 Feb;3(1):47-52
references: 20160195
references: Circ Cardiovasc Genet. 2009 Feb;2(1):16-25
references: 20031563
references: Acta Med Croatica. 2010 Oct;64(4):237-45
references: 21688606
references: Ann Hum Genet. 1995 Jan;59(1):97-105
references: 7762987
references: Circulation. 1979 Mar;59(3):607-9
references: 761341
references: J Clin Endocrinol Metab. 2006 Sep;91(9):3521-7
references: 16787988
references: Pharmacogenet Genomics. 2012 Feb;22(2):95-104
references: 22143414
references: Am J Med. 1977 May;62(5):707-14
references: 193398
references: Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2264-76
references: 20864672
references: Control Clin Trials. 1990 Apr;11(2):116-28
references: 2161310
references: J Intern Med. 2011 Jan;269(1):94-106
references: 21054587
references: Int J Cardiol. 2013 Jun 5;166(1):8-14
references: 22503572
references: Atherosclerosis. 2012 May;222(1):158-66
references: 22417841
references: Eur Heart J. 2012 Jan;33(2):238-51
references: 22003152
references: PLoS One. 2011 Apr 05;6(4):e18208
references: 21490708
references: Atherosclerosis. 1996 Jul;124 Suppl:S11-20
references: 8831911
references: Hum Mol Genet. 2008 May 1;17(9):1318-28
references: 18204052
references: PLoS Genet. 2010 Apr 29;6(4):e1000928
references: 20442857
references: Circulation. 2004 Feb 24;109(7):837-42
references: 14757686
references: J Formos Med Assoc. 2007 Oct;106(10):799-807
references: 17964958
references: Lancet. 2010 May 1;375(9725):1536-44
references: 20435228
references: Ann Hum Genet. 2011 Sep;75(5):605-11
references: 21834908