title: Study of fungal isolates in patients with chronic diarrhea at a tertiary care hospital in north India.
abstract: OBJECTIVE
  The aim of this study was to evaluate the rate of isolation and antifungal susceptibility profile of various opportunistic yeasts in faeces of patients with chronic diarrhea.
  
  
  METHODS
  The study included 120 patients who received the consultation and treatment for the complaints of chronic diarrhea for a period of more than 15 days.
  
  
  METHODS
  The microscopy of samples of stool was followed by the culture on Sabourauds-dextrose agar. Isolate were tried for their sensitivity to fluconazole, flucytosine, amphotericin B and voriconazole.
  
  
  RESULTS
  The significant growth of fungal organism was seen in 32 (26.7%) stool specimen. These fungal isolates include five (15.6%) of C. albicans, 14 (43.8%) of C. tropicalis, five (15.6%) of C. krusei, two (6.3%) of C. famata, two (6.3%) of C. parapsilosis isolates and one isolate each of C. lusitaniae, C. guilliermondii, Stephanoascus ciferri and Trichosporon asahii (3.1% each). Most of the yeast isolates (65.6%) were found to be sensitive to all four antifungal agents i.e., fluconazole, flucytosine, amphotericin B and voriconazole. The highest resistance was seen against fluconazole in 10 (31.3%) isolates followed by flucytosine in eight (25%) isolates. No resistance to voriconazole was observed in any of the isolates. The resistance to the antifungal agents was higher among the other species of Candida compared to C. albicans.
  
  
  CONCLUSIONS
  The study could establish the relation between the opportunistic yeasts and chronic diarrhea and gives information on the antifungal sensitivity profile of the isolated yeasts.
authors: Department of Laboratory, Indian Spinal Injuries Centre, Sector-C, Vasant Kunj, 110070 New Delhi, India. drmicro123@gmail.com
authors: P
authors: P
authors: Banerjee
authors: R
authors: R
authors: Kaur
authors: B
authors: B
authors: Uppal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology; D002175:Candida / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology; D026141:Drug Resistance, Multiple, Fungal; D005243:Feces / Q000382:microbiology; D005260:Female; D005658:Fungi / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000453:epidemiology* / Q000382:microbiology; D011446:Prospective Studies; D013045:Species Specificity; D062606:Tertiary Care Centers / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents