title: [Expression of Bcl-2, PD-L1 and its clinical significance in colorectal cancer].
abstract: OBJECTIVE
  To study the expression of Bcl-2 and PD-L1 in colon cancer and its relationship with metastasis.
  
  
  METHODS
  Tumor samples were collected from 57 cases of colon cancer, and tumor adjacent normal mucous tissue were obtained as normal control. The expressions of Bcl-2 and PD-L1 were assayed by immunohistochemical staining, and its correlations with patients' clinical pathological indexes were analyzed.
  
  
  RESULTS
  The positive rate of Bcl-2 protein was 75.43% and 52.63% in colon cancer tissues and tumor adjacent colon mucous tissue respectively, with statistically significant difference (P<0.05). While the positive rate of PD-L1 was 45.61% and 15.79% in colon cancer tissues and tumor adjacent colon mucous tissue respectively, also with signficant difference (P<0.01). The positive rate of Bcl-2 was correlated with cellular differentiation, and the positive rate of PD-L1 protein was correlated with lymph node metastasis (P<0.05).
  
  
  CONCLUSIONS
  The expression of Bcl-2 may be associated with colon cancer pathologic differentiation, and the expression of PD-L1 may be associated with colon cancer metastasis.
authors: Department of Composite Medicine, Baotou Tumor Hospital, Baotou 014030, China.
authors: Mei-Yun
authors: MY
authors: Zhang
authors: Yong-Yan
authors: YY
authors: Yang
authors: Xin-Hua
authors: XH
authors: Wang
authors: Xiao-Feng
authors: XF
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060890:B7-H1 Antigen / Q000235:genetics / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*
chemical_list: D060890:B7-H1 Antigen; D014408:Biomarkers, Tumor; C423236:CD274 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2