title: [Early molecular diagnosis of lung cancer: a method to rule out the disease].
abstract: Aim of this study was the determination of new markers for the diagnosis of lung cancer. 61 patients with non-small cell lung cancer (NSCLC) and 42 controls were enrolled. In the NSCLC patients the following markers were increased: H2O2 in exhaled breath condensate, pentane, hexane, nonenal, trans-2-heptanal, trans-2-nonenal in exhaled breath, while pentanal was decreased. Using multivariate statistical models, a sensitivity of 73.8% and a specificity of 76.8% were calculated. This study shows that with this non-invasive test followed by a most powerful test on positives (e.g. PET) it is possible to decrease the number of false positives.
authors: Laboratorio di Tossicologia Industriale, Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Università di Parma, Via Gramsci 14, 43126 Parma, Italy. massimo.corradi@unipr.it
authors: M
authors: M
authors: Corradi
authors: D
authors: D
authors: Poli
authors: R
authors: R
authors: Tillo
authors: M
authors: M
authors: Goldoni
authors: O
authors: O
authors: Acampa
authors: P
authors: P
authors: Mozzoni
authors: F
authors: F
authors: Sabbadini
authors: S
authors: S
authors: Pinelli
authors: P
authors: P
authors: Carbognani
authors: E
authors: E
authors: Internullo
authors: A
authors: A
authors: Casalini
authors: G
authors: G
authors: Gervasi
authors: A
authors: A
authors: Filetti
authors: A
authors: A
authors: Mutti
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques