title: An unusual breast lump: osseous metaplasia.
abstract: We present a rare case of osseous metaplasia in the breast with no other associated breast pathology. A 46-year-old HIV-positive lady presented to the breast clinic with new onset intermittent left-sided mastalgia. Clinical examination revealed an indeterminate mass in the left breast with palpable left axillary lymphadenopathy. Mammography and ultrasonography were suggestive of a possible malignancy, with the latter also detecting the presence of abnormal nodes in the axilla. An ultrasound-guided core biopsy of the breast lesion showed only hyalinised normal breast tissue on two occasions. Owing to the diagnostic uncertainty, the patient underwent a wire-guided excision biopsy of the breast lesion, with the final histology demonstrating bone matrix deposition with viable osteocytes within lacunae and associated osteoclasts with spindle cells, consistent with osseous metaplasia. A core biopsy of the axillary lymph nodes was normal. The patient was therefore reassured and discharged from the clinic.
authors: Department of General Surgery, Wycombe Hospital, Bucks NHS Trust, Bucks, UK. missmeerajoshi@gmail.com
authors: Meera
authors: M
authors: Joshi
authors: Dionysios D
authors: DD
authors: Remoundos
authors: Farid
authors: F
authors: Ahmed
authors: Giles
authors: G
authors: Cunnick
authors: Gabrielle
authors: G
authors: Rees
mesh_terms: D001365:Axilla; D062005:Biopsy, Large-Core Needle; D001941:Breast Diseases / Q000150:complications / Q000175:diagnosis*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008206:Lymphatic Diseases / Q000150:complications / Q000175:diagnosis*; D008327:Mammography; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000150:complications / Q000175:diagnosis*
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