title: Osmotic regulation of seamless tube growth.
abstract: Most organs are composed of tubes of differing cellular architectures, including intracellular 'seamless' tubes. Two studies examining the morphogenesis of the seamless tubes formed by the excretory canal cell in Caenorhabditis elegans reveal a previously unappreciated role for osmoregulation of tubulogenesis: hyperosmotic shock recruits canalicular vesicles to the lumenal membrane to promote seamless tube growth.
authors: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.
authors: Jodi
authors: J
authors: Schottenfeld-Roames
authors: Amin S
authors: AS
authors: Ghabrial
mesh_terms: D000818:Animals; D020346:Aquaporins / Q000378:metabolism*; D017173:Caenorhabditis elegans / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D042583:Lymphangiogenesis; D042601:Lymphatic Vessels / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D014882:Water-Electrolyte Balance; D000098551:Prospero-Related Homeobox 1 Protein
chemical_list: D020346:Aquaporins; D029742:Caenorhabditis elegans Proteins; D003598:Cytoskeletal Proteins; C488174:ERM-1 protein, C elegans; D018398:Homeodomain Proteins; D025521:Tumor Suppressor Proteins; C108330:aquaporin 8; D000098551:Prospero-Related Homeobox 1 Protein
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