title: Role of antiviral therapy in the management of hepatocellular carcinoma.
abstract: Globally, hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection leads to liver fibrosis and cirrhosis, which in turn causes resultant hepatocellular carcinoma (HCC). Frequently, HCC recurs very soon even after a potentially curative treatment such as surgical interference or locoregional ablative therapies. Chronic HBV/HCV infection is often responsible for this recurrence, through secondary carcinogenesis. Antiviral therapy after a curative treatment of HCC plays an important role in preventing or delaying recurrence and improves survival in patients with HBV/HCV infection-related HCC. This article reviews the worldwide epidemiology of HBV/HCV infection, the association of viral infection with HCC, the mechanism of hepatitis virus-related hepatocarcinogenesis, and the paramount importance of antiviral therapy in the management of HCC.
authors: Department of Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China. yongsongguan@yahoo.com
authors: Yong-Song
authors: YS
authors: Guan
authors: Qing
authors: Q
authors: He
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D017209:Apoptosis; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000453:epidemiology / Q000601:surgery / Q000821:virology; D002353:Carrier State / Q000453:epidemiology; D002472:Cell Transformation, Viral; D003131:Combined Modality Therapy; D000529:Complementary Therapies; D004359:Drug Therapy, Combination; D015967:Gene Expression Regulation, Viral; D016174:Hepacivirus / Q000235:genetics / Q000472:pathogenicity; D006498:Hepatectomy; D006515:Hepatitis B virus / Q000235:genetics / Q000472:pathogenicity; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D054884:Host-Pathogen Interactions; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000601:surgery / Q000821:virology; D055502:Secondary Prevention; D014412:Tumor Virus Infections / Q000150:complications / Q000188:drug therapy*; D016662:Virus Integration
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents