title: A New extractive spectrophotometric method for determination of rizatriptan dosage forms using bromocresol green.
abstract: OBJECTIVE
  Rizatriptan is used effectively for the treatment of migraine headache. In this study, a simple, rapid and low cost spectrophotometric method based on the ion-pair complexation is proposed for the determination of rizatriptan in raw material and dosage forms.
  
  
  METHODS
  The ion-pair complexation using bromocresol green as reagent was performed in a buffer solution and the absorbance was measured by a spectrophotometer. The ion-pair formation conditions were optimized and the accuracy and precision of the method were calculated.
  
  
  CONCLUSIONS
  Best results were achieved by using 6 ml of the bromocresol green reagent in the presence of phosphate buffer (pH 3.0). The stoichiometry of the resulted complex was 1:1. The within-day and between-day precision values were lower than 2.9 and 1.8 percent for the calibration range of 0.5-50 and 10-100 μg/ml, respectively. The proposed method was successfully used for the determination of rizatriptan in dosage forms without any interference.
authors: Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran. souri@sina.tums.ac.ir.
authors: Effat
authors: E
authors: Souri
authors: Abbas
authors: A
authors: Kaboodari
authors: Noushin
authors: N
authors: Adib
authors: Massoud
authors: M
authors: Amanlou
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