title: Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives.
abstract: Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.
authors: Institut des Biomole´cules Max Mousseron, UMR 5247, CNRS, Universite´s Montpellier I et II, UFR des Sciences Pharmaceutiques et Biologiques, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France. ludovic.maillard@univ-montp1.fr
authors: Ludovic T
authors: LT
authors: Maillard
authors: Sébastien
authors: S
authors: Bertout
authors: Ophélie
authors: O
authors: Quinonéro
authors: Gülşen
authors: G
authors: Akalin
authors: Gülhan
authors: G
authors: Turan-Zitouni
authors: Pierre
authors: P
authors: Fulcrand
authors: Fatih
authors: F
authors: Demirci
authors: Jean
authors: J
authors: Martinez
authors: Nicolas
authors: N
authors: Masurier
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D025141:Drug Resistance, Fungal / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D041681:NIH 3T3 Cells; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000935:Antifungal Agents; D013844:Thiazoles