title: Iron(II)-catalyzed intramolecular aminohydroxylation of olefins with functionalized hydroxylamines.
abstract: A diastereoselective aminohydroxylation of olefins with a functionalized hydroxylamine is catalyzed by new iron(II) complexes. This efficient intramolecular process readily affords synthetically useful amino alcohols with excellent selectivity (dr up to > 20:1). Asymmetric catalysis with chiral iron(II) complexes and preliminary mechanistic studies reveal an iron nitrenoid is a possible intermediate that can undergo either aminohydroxylation or aziridination, and the selectivity can be controlled by careful selection of counteranion/ligand combinations.
authors: Department of Chemistry, Georgia State University, 100 Piedmont Avenue SE, Atlanta, Georgia 30303, United States.
authors: Guan-Sai
authors: GS
authors: Liu
authors: Yong-Qiang
authors: YQ
authors: Zhang
authors: Yong-An
authors: YA
authors: Yuan
authors: Hao
authors: H
authors: Xu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry*; D019811:Hydroxylamine / Q000138:chemical synthesis* / Q000737:chemistry*; D006900:Hydroxylation; D015394:Molecular Structure
chemical_list: D000475:Alkenes; D005296:Ferrous Compounds; D019811:Hydroxylamine