title: Bioactive Lipidic Extracts from Octopus (Paraoctopus limaculatus): Antimutagenicity and Antiproliferative Studies.
abstract: Fractions from an organic extract from fresh octopus (Paraoctopus limaculatus) were studied for biological activities such as antimutagenic and antiproliferative properties using Salmonella tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. A chloroform extract obtained from octopus tentacles was sequentially fractionated using thin layer chromatography (TLC), and each fraction was tested for antimutagenic and antiproliferative activities. Organic extract reduced the number of revertants caused by aflatoxin B(1) showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. Based on the results obtained, the isolated fractions obtained from octopus contain compounds with chemoprotective properties that reduce the mutagenicity of AFB(1) and proliferation of cancer cell lines.
authors: Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Apartado Postal 1658, 83000 Hermosillo, SON, Mexico.
authors: Carolina
authors: C
authors: Moreno-Félix
authors: Griselda
authors: G
authors: Wilson-Sánchez
authors: Susana-Gabriela
authors: SG
authors: Cruz-Ramírez
authors: Carlos
authors: C
authors: Velázquez-Contreras
authors: Maribel
authors: M
authors: Plascencia-Jatomea
authors: Ana
authors: A
authors: Acosta
authors: Lorena
authors: L
authors: Machi-Lara
authors: María-Lourdes
authors: ML
authors: Aldana-Madrid
authors: Josafat-Marina
authors: JM
authors: Ezquerra-Brauer
authors: Fernando
authors: F
authors: Rocha-Alonzo
authors: Armando
authors: A
authors: Burgos-Hernández
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