title: N-Heterocyclic carbene-palladium(II)-1-methylimidazole complex catalyzed Suzuki-Miyaura coupling of benzylic chlorides with arylboronic acids or potassium phenyltrifluoroborate in neat water.
abstract: An easily available N-heterocyclic carbene-palladium(II)-1-methylimidazole complex showed efficient catalytic activity in the Suzuki-Miyaura coupling of benzylic chlorides with arylboronic acids or potassium phenyltrifluoroborate in neat water under mild conditions, providing an alternative method for the synthesis of diarylmethane derivatives, which widely exist in molecules with pharmaceutical activities and are also frequently found as subunits in supramolecules. Under the optimal conditions, all reactions performed well to give the desired products in moderate to almost quantitative yields in an environmentally benign medium within 12 h, extending their applications toward potentially industrial processes.
authors: College of Chemistry and Materials Engineering, Wenzhou University, Chashan University Town, Wenzhou, Zhejiang Province 325035, People's Republic of China.
authors: Yun
authors: Y
authors: Zhang
authors: Meng-Ting
authors: MT
authors: Feng
authors: Jian-Mei
authors: JM
authors: Lu
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry*; D001881:Borates / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D001593:Benzyl Compounds; D001881:Borates; D001897:Boronic Acids; D006571:Heterocyclic Compounds; D007093:Imidazoles; D009942:Organometallic Compounds; D014867:Water; C030011:carbene; D010165:Palladium; C021292:benzyl chloride; D008697:Methane; C018100:1-methylimidazole