title: Schizophyllum commune: a new organism in eye infection.
abstract: OBJECTIVE
  We report a case of mycotic keratitis caused by a rare fungus Schizophyllum commune.
  
  
  METHODS
  Clinical examination, slit-lamp examination, and microbiological evaluation of the corneal ulcer were done, and its treatment outcome was studied. The fungal etiology was established by conventional microbiological techniques, polymerase chain reaction and speciation by DNA sequencing.
  
  
  RESULTS
  Corneal scraping showed the presence of fungal filaments. The fungus was identified as S. commune based on DNA sequence analysis of the internal transcribed spacer region. The organism was susceptible to amphotericin B and voriconazole and demonstrated resistance to anidulafungin, itraconazole, and fluconazole. Therapeutic keratoplasty was performed but there was recurrence of the infection in the graft, which was controlled with topical voriconazole and intracameral amphotericin B. At the end of 3 months, the affected eye had developed phthisis bulbi.
  
  
  CONCLUSIONS
  The best of our knowledge, this is the first reported case of keratitis caused by the rare fungus S. commune. Management of these cases is difficult, and surgical procedures may be needed.
authors: Ocular Microbiology Services, Priyamvada Birla Aravind Eye Hospital, Kolkata, West Bengal, India. sumansaha13@gmail.com
authors: Suman
authors: S
authors: Saha
authors: Jayangshu
authors: J
authors: Sengupta
authors: Debdulal
authors: D
authors: Banerjee
authors: Archana
authors: A
authors: Khetan
authors: Santi Mohan
authors: SM
authors: Mandal
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D003315:Cornea / Q000382:microbiology / Q000473:pathology; D016039:Corneal Transplantation; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D008297:Male; D008969:Molecular Sequence Data; D009181:Mycoses / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D016133:Polymerase Chain Reaction; D011743:Pyrimidines / Q000008:administration & dosage; D012567:Schizophyllum / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole
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