title: Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer.
abstract: BACKGROUND
  Fascin-1 (FSCN1) plays an important role in cancer development and is associated with invasion and metastasis. Therefore, we explored the expression and localization of FSCN1 in epithelial ovarian cancer (EOC).
  
  
  METHODS
  Expression analysis was performed by immunohistochemistry of paraffin-embedded tumor samples from 89 patients with EOC. Staining intensity and the percentage of positively stained tumor cells were used to calculate an immunoreactive score of 0-12 (IRS). These results were correlated to clinical and pathological characteristics as well as to patient survival.
  
  
  RESULTS
  Negative (IRS=0), weak (IRS=0-2) and strong (IRS>2) expression of FSCN1 in EOC was found in 5 (5.6%), 30 (33.7%) and 54 (60.7%) tumor samples, respectively. There was a strong correlation of residual postoperative tumor of >1 cm with higher immunoexpression of FSCN1 (p=0.04). Lower FSCN1 expression was associated with significantly poorer overall survival (p=0.02).
  
  
  CONCLUSIONS
  FSCN1 is frequently expressed in primary EOC. Its prognostic impact and function remains inconclusive and should be further examined in larger trials.
authors: Department of Obstetrics and Gynecology, J.W. Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. hanker@med.uni-frankfurt.de
authors: Lars C
authors: LC
authors: Hanker
authors: Thomas
authors: T
authors: Karn
authors: Uwe
authors: U
authors: Holtrich
authors: Monika
authors: M
authors: Graeser
authors: Sven
authors: S
authors: Becker
authors: Joscha
authors: J
authors: Reinhard
authors: Eugen
authors: E
authors: Ruckhäberle
authors: Heidrun
authors: H
authors: Gevensleben
authors: Achim
authors: A
authors: Rody
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002352:Carrier Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008840:Microfilament Proteins / Q000032:analysis*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D014408:Biomarkers, Tumor; D002352:Carrier Proteins; C502658:FSCN1 protein, human; D008840:Microfilament Proteins