title: Increased gastric cancer risk with PTEN IVS4 polymorphism in a Turkish population.
abstract: We aimed to investigate the association of the phosphatase and tensin homolog (PTEN) IVS4 polymorphism with a gastric cancer (GC) risk in the Turkish population. A hospital-based case-control study was conducted in 93 patients with GC, and 113 healthy controls. The PTEN IVS4 (rs no: 3830675) polymorphism was determined by using polymerase chain reaction-restriction fragment length polymorphism analysis. The PTEN IVS4 (-/-) genotype exhibited a significantly elevated risk for GC compared to controls (p<0.005; odds ratio: 1.6, 95% confidence interval: 1.19-2.14). Analyses on clinicopathological parameters showed that PTEN IVS4 genotypes were not associated with any of the variables of patients with GC (p>0.05). In conclusion, the PTEN IVS4 polymorphism might contribute to the development of GC in a Turkish population. Further studies, including comparison of the PTEN IVS4 polymorphism with plasma and tissue expressions of PTEN in larger study size groups will provide a further assessment of the PTEN IVS4 polymorphism in GC patients.
authors: NPO Organization to Support Peritoneal Dissemination Treatment, Kishiwada City, Osaka, Japan. drecanbay@gmail.com
authors: Emel
authors: E
authors: Canbay
authors: Ozlem T
authors: OT
authors: Kahraman
authors: Dursun
authors: D
authors: Bugra
authors: Burcu
authors: B
authors: Caykara
authors: M Fatih
authors: MF
authors: Seyhan
authors: Turker
authors: T
authors: Bulut
authors: Sumer
authors: S
authors: Yamaner
authors: Oguz
authors: O
authors: Ozturk
mesh_terms: D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics*; D014421:Turkey
chemical_list: D017931:DNA Primers; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human