title: Hijacking of Basic Research: The Case of Synthetic Cannabinoids.
abstract: Gathering and communicating knowledge are important aspects of the scientific endeavor. Yet presentation of data in public forums such as scientific meetings and publications makes it available not only to scientists, but also to others who may have different ideas about how to use research findings. A recent example of this type of hijacking is the introduction of synthetic cannabinoids that are sprayed on herbal products and subsequently smoked for their marijuana-like intoxicating properties. Originally developed for the legitimate research purpose of furthering understanding of the cannabinoid system, these synthetic cannabinoids are being abused worldwide, creating issues for regulatory and law enforcement agencies that are struggling to keep up with the growing number of compounds of various structural motifs. Basic and clinical scientists need to provide advice now to facilitate decision-making about the health threats posed by this emerging problem.
authors: Senior behavioral pharmacologist in RTI International's Discovery and Analytical Sciences unit.
authors: Jenny L
authors: JL
authors: Wiley
authors: Julie A
authors: JA
authors: Marusich
authors: John W
authors: JW
authors: Huffman
authors: Robert L
authors: RL
authors: Balster
authors: Brian F
authors: BF
authors: Thomas
references: Mol Pharmacol. 1991 Nov;40(5):656-65
references: 1944237
references: J Pharmacol Exp Ther. 1998 May;285(2):553-60
references: 9580597
references: J Mass Spectrom. 2010 Oct;45(10):1186-94
references: 20857386
references: Arch Gen Psychiatry. 2001 Apr;58(4):322-8
references: 11296091
references: Drug Alcohol Depend. 2011 Sep 1;117(2-3):152-7
references: 21316162
references: Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3
references: 16005223
references: J Pharmacol Exp Ther. 1959 Nov;127:241-50
references: 13809587
references: J Anal Toxicol. 2012 Jun;36(5):293-302
references: 22582264
references: Toxicol Lett. 2010 Sep 1;197(3):157-62
references: 20566335
references: J Pharmacol Exp Ther. 1998 Jun;285(3):995-1004
references: 9618400
references: Drug Alcohol Depend. 1995 Nov;40(1):81-6
references: 8746928
references: Forensic Sci Int. 2010 May 20;198(1-3):31-8
references: 20117892
references: J Med Chem. 1995 Aug 4;38(16):3094-105
references: 7636873
references: J Pharmacol Exp Ther. 1995 Oct;275(1):1-6
references: 7562536
references: J Pharmacol Exp Ther. 1992 Dec;263(3):1118-26
references: 1335057
references: Fundam Appl Toxicol. 1993 Jul;21(1):59-65
references: 8365586
references: Eur J Pharmacol. 2009 Aug 1;615(1-3):102-7
references: 19470387
references: Forensic Sci Int. 2009 Oct 30;191(1-3):58-63
references: 19589652
references: J Med Chem. 1992 Jan;35(1):124-35
references: 1732519
references: Drug Alcohol Depend. 2000 Aug 1;60(2):133-40
references: 10940540
references: J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 1;878(27):2659-63
references: 20378423
references: Mol Pharmacol. 1988 Nov;34(5):605-13
references: 2848184
references: Dtsch Arztebl Int. 2009 Jul;106(27):464-7
references: 19652769
references: Br J Pharmacol. 2010 Jun;160(3):585-93
references: 20100276
references: J Emerg Med. 2011 Mar;40(3):296-9
references: 21167669
references: Schizophr Res. 2010 May;118(1-3):309-10
references: 20056392
references: J Mass Spectrom. 2009 May;44(5):832-7
references: 19189348
references: Curr Med Chem. 2010;17(14):1393-410
references: 20166925
references: Pharmacol Biochem Behav. 1991 Nov;40(3):471-8
references: 1666911
references: J Pharmacol Exp Ther. 1990 Nov;255(2):511-22
references: 2243340
references: J Pharmacol Exp Ther. 1996 Sep;278(3):989-99
references: 8819477
references: Curr Pharm Des. 2000 Sep;6(13):1323-37
references: 10903395