title: Antiproteinuric effect of angiotensin receptor blockers in normotensive patients with proteinuria: a meta-analysis of randomized controlled trials.
abstract: BACKGROUND
  The objective of this article is to evaluate the antiproteinuric effect of angiotensin receptor blockers (ARBs) in normotensive patients with proteinuria.
  
  
  METHODS
  We reviewed randomized controlled trials assessing ARBs treatment in patients with normotension and proteinuria. Data concerning the study design, patient characteristics, and outcomes were extracted. Ratio of means was calculated by using the generalized inverse variance method.
  
  
  RESULTS
  Eight trials involving 866 patients were included in this study. Compared with a control group, ARBs group was associated with a significant reduction in urinary protein excretion (ratio of means 0.53, 95% CI 0.44-0.64). Subgroup analysis shows that ARBs therapy resulted in a significant decrease in urinary protein excretion in diabetic patients with microalbuminuria or nondiabetic nephropathy with overt proteinuria (ratio of means 0.57, 95% CI 0.47-0.69 and 0.46, 95% CI 0.26-0.83, respectively), in a Western population or an Asian population (ratio of means 0.61, 95% CI 0.54-0.69 and 0.49, 95% CI 0.37-0.64, respectively), and in patients followed up for one to three months or three to 12 months (ratio of means 0.62, 95% CI 0.54-0.70 and 0.49, 95% CI 0.38-0.63, respectively).
  
  
  CONCLUSIONS
  The data suggest that ARBs may have beneficial effects in preventing the progression of proteinuria in normotensive patients with renal disease.
authors: Sun Yat-sen University, China.
authors: Deng-feng
authors: DF
authors: Geng
authors: Wei-feng
authors: WF
authors: Sun
authors: Li
authors: L
authors: Yang
authors: Ge
authors: G
authors: En
authors: Jing-feng
authors: JF
authors: Wang
mesh_terms: D000328:Adult; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D003404:Creatinine
keywords: Angiotensin receptor blockers; microalbuminuria; normotension; proteinuria; type 2 diabetes mellitus