title: Reactive oxygen species in vascular formation and development.
abstract: Reactive oxygen species (ROS) are derived from the metabolism of oxygen and are traditionally viewed as toxic byproducts that cause damage to biomolecules. It is now becoming widely acknowledged that ROS are key modulators in a variety of biological processes and pathological states. ROS mediate key signaling transduction pathways by reversible oxidation of certain signaling components and are involved in the signaling of growth factors, G-protein-coupled receptors, Notch, and Wnt and its downstream cascades including MAPK, JAK-STAT, NF-κB, and PI3K/AKT. Vascular formation and development is one of the most important events during embryogenesis and is vital for postnasal tissue repair. In this paper, we will discuss how ROS regulate different steps in vascular development, including smooth muscle cell differentiation, angiogenesis, endothelial progenitor cells recruitment, and vascular cell migration.
authors: Department of Cardiology, Zhejiang University, Hangzhou, Zhejiang, China.
authors: Yijiang
authors: Y
authors: Zhou
authors: Hui
authors: H
authors: Yan
authors: Meiqun
authors: M
authors: Guo
authors: Jianhua
authors: J
authors: Zhu
authors: Qingzhong
authors: Q
authors: Xiao
authors: Li
authors: L
authors: Zhang
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism; D019255:NADPH Oxidases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D051793:Hypoxia-Inducible Factor 1; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases
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