title: Cognitive function affects trainability for physical performance in exercise intervention among older adults with mild cognitive impairment.
abstract: BACKGROUND
  Although much evidence supports the hypothesis that cognitive function and physical function are interrelated, it is unclear whether cognitive decline with mild cognitive impairment influences trainability of physical performance in exercise intervention. The purpose of this study was to examine the association between cognitive function at baseline and change in physical performance after exercise intervention in older adults with mild cognitive impairment.
  
  
  METHODS
  Forty-four older adults diagnosed with mild cognitive impairment based on the Peterson criteria (mean age 74.8 years) consented to and completed a 6-month twice weekly exercise intervention. The Timed Up and Go (TUG) test was used as a measure of physical performance. The Mini-Mental State Examination (MMSE), Trail Making Test Part B, Geriatric Depression Scale, baseline muscle strength of knee extension, and attendance rate of intervention, were measured as factors for predicting trainability.
  
  
  RESULTS
  In the correlation analysis, the change in TUG showed modest correlations with attendance rate in the exercise program (r = -0.354, P = 0.027) and MMSE at baseline (r = -0.321, P = 0.034). A multiple regression analysis revealed that change in TUG was independently associated with attendance rate (β = -0.322, P = 0.026) and MMSE score (β = -0.295, P = 0.041), controlling for age and gender.
  
  
  CONCLUSIONS
  General cognitive function was associated with improvements in physical performance after exercise intervention in subjects with mild cognitive impairment. Further research is needed to examine the effects of exercise programs designed to address cognitive obstacles in older adults with mild cognitive impairment.
authors: Section for Health Promotion, Department for Research and Development to Support Independent Life of Elderly, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Aichi, Japan.
authors: Kazuki
authors: K
authors: Uemura
authors: Hiroyuki
authors: H
authors: Shimada
authors: Hyuma
authors: H
authors: Makizako
authors: Takehiko
authors: T
authors: Doi
authors: Daisuke
authors: D
authors: Yoshida
authors: Kota
authors: K
authors: Tsutsumimoto
authors: Yuya
authors: Y
authors: Anan
authors: Takao
authors: T
authors: Suzuki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition; D060825:Cognitive Dysfunction / Q000453:epidemiology*; D003863:Depression / Q000453:epidemiology; D004522:Educational Status; D005081:Exercise Therapy / Q000379:methods*; D015577:Geriatric Assessment; D006304:Health Status; D006801:Humans; D053580:Muscle Strength; D009483:Neuropsychological Tests; D010809:Physical Fitness
keywords: Timed Up and Go test; exercise; mobility; rehabilitation
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