title: New titin (connectin) isoforms and their functional role in striated muscles of mammals: facts and suppositions.
abstract: This review summarizes results of our studies on titin isoform composition in vertebrate striated muscles under normal conditions, during hibernation, real and simulated microgravity, and under pathological conditions (stiff-person syndrome, post-apoplectic spasticity, dilated cardiomyopathy, cardiac hypertrophy). Experimental evidence for the existence in mammalian striated muscles of higher molecular weight isoforms of titin (NT-isoforms) in addition to the known N2A-, N2BA-, and N2B-titin isoforms was obtained. Comparative studies of changes in titin isoform composition and structure-functional properties of human and animal striated muscles during adaptive and pathological processes led to a conclusion about the key role of NT-isoforms of titin in maintenance of sarcomere structure and contractile function of these muscles.
authors: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. vikhlyantsev@iteb.ru
authors: I M
authors: IM
authors: Vikhlyantsev
authors: Z A
authors: ZA
authors: Podlubnaya
mesh_terms: D000818:Animals; D064211:Connectin; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D008322:Mammals / Q000235:genetics / Q000378:metabolism*; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000201:enzymology*; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D064211:Connectin; D007527:Isoenzymes; D009124:Muscle Proteins; C577285:TTN protein, human; D011494:Protein Kinases