title: Association study of integrins beta 1 and beta 2 gene polymorphism and papillary thyroid cancer.
abstract: BACKGROUND
  We investigated whether single nucleotide polymorphisms (SNPs) of integrin beta 1 (ITGB1) and integrin beta 2 (ITGB2) contribute to the development of papillary thyroid cancer (PTC).
  
  
  METHODS
  Two synonymous SNPs (rs2230396 and rs2298141) of ITGB1 and 1 synonymous SNP (rs2352326), 1 5' URT-region SNP (rs2070947), and 1 promoter SNP (rs2070946) of ITGB2 SNPs were genotyped using direct sequencing in 94 patients with PTC and 213 healthy controls. Genetic data were analyzed using SNPStats (http://bioinfo.iconcologia.net/SNPstats), Helix Tree (Golden Helix Inc, Bozeman, MT), and SNPAnalyzer (ISTECH Corp, Goyang City, Republic of Korea).
  
  
  RESULTS
  The promoter SNP (rs2070946) of ITGB2 was significantly associated with the development of PTC (dominant model, log-additive model). The G allele frequencies of the promoter SNP (rs2070946) of ITBG2 in patients with PTC (19.9%) were increased by about 2-fold compared with controls (10.2%).
  
  
  CONCLUSIONS
  Our results suggest that a promoter SNP (rs2070946) of ITGB2 might be associated with a risk of PTC.
authors: Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors: Young Gyu
authors: YG
authors: Eun
authors: Su Kang
authors: SK
authors: Kim
authors: Joo-Ho
authors: JH
authors: Chung
authors: Kee Hwan
authors: KH
authors: Kwon
mesh_terms: D018821:CD18 Antigens / Q000235:genetics*; D002291:Carcinoma, Papillary / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D019012:Integrin beta1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D056910:Republic of Korea; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: D018821:CD18 Antigens; D019012:Integrin beta1