title: Adenovirus DNA replication.
abstract: Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents. On the other hand, adenoviruses are notorious pathogens in people with compromised immune functions. This article will briefly summarize the basic replication strategy of adenoviruses and the key proteins involved and will deal with the new developments since 2006. In addition, we will cover the development of antivirals that interfere with human adenovirus (HAdV) replication and the impact of HAdV on human disease.
authors: Department of Molecular Cell Biology, Leiden University Medical Centre, 2333 ZC Leiden, The Netherlands. r.c.hoeben@lumc.nl
authors: Rob C
authors: RC
authors: Hoeben
authors: Taco G
authors: TG
authors: Uil
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000502:physiology*; D000258:Adenovirus Infections, Human / Q000503:physiopathology*; D000998:Antiviral Agents / Q000494:pharmacology*; D019951:DNA Polymerase beta / Q000378:metabolism; D004261:DNA Replication / Q000187:drug effects* / Q000235:genetics / Q000502:physiology*; D004279:DNA, Viral / Q000096:biosynthesis*; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D010750:Phosphoproteins / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D010750:Phosphoproteins; D011498:Protein Precursors; D014764:Viral Proteins; C085476:pTP protein, adenovirus; D019951:DNA Polymerase beta
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