title: Thrombotic thrombocytopenic purpura (TTP) leading to pseudotumour's autoimmune pancreatitis (AIP): a case report.
abstract: BACKGROUND
  Autoimmune pancreatitis is an idiopathic inflammatory disease that produces pancreatic masses and ductal strictures. This benign disease can be associated with extrapancreatic manifestations including cholangitis, sialadenitis, inflammatory bowel disease or retroperitoneal fibrosis, mediastinal adenopathy, interstitial nephritis mainly due to immunoglobulin G4 (Ig G4), and occasional association with other auto-immune diseases.
  
  
  METHODS
  We report a 57-year-old woman who developed thrombotic thrombocytopenic purpura (TTP) and pseudo-tumour's seronegative autoimmune pancreatitis (AIP) type 1. The patient was initially treated with pulse corticosteroids and plasmapheresis; afterwards two cures of i.v. Vincristin with inadequate response and subsequently with four weekly pulses dose of i.v. Rituximab, leading to full remission.
  
  
  CONCLUSIONS
  This case represents the first report of TTP associated to pseudo-tumour's seronegative AIP type 1 successfully treat by Rituximab.
authors: Centre for Food and Taste Sciences (CSGA), UMR 6265 CNRS (National Centre for Scientific Research), UMR 1324 INRA, University of Burgundy, 9 E Boulevard Jeanne d'Arc, 21000 Dijon, France. cfoguem@yahoo.fr
authors: Clovis
authors: C
authors: Foguem
authors: Arnaud
authors: A
authors: Boruchowicz
authors: Philippe
authors: P
authors: Cuingnet
authors: Xavier
authors: X
authors: Kyndt
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010195:Pancreatitis / Q000188:drug therapy / Q000209:etiology*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications*; D000069283:Rituximab
chemical_list: D000893:Anti-Inflammatory Agents; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab