title: Ceramicines from Chisocheton ceramicus as lipid-droplets accumulation inhibitors.
abstract: In our search for lipid-droplets accumulation (LDA) inhibitors, some ceramicines, a series of limonoids isolated from the barks of Chisocheton ceramicus, were discovered to be active as anti-LDA. Preliminary structure-activity relationships (SAR) of ceramicines as LDA inhibitors based on ceramicines A-L (1-12) and ceramicine B derivatives were described.
authors: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
authors: Chin Piow
authors: CP
authors: Wong
authors: Jun
authors: J
authors: Deguchi
authors: Alfarius Eko
authors: AE
authors: Nugroho
authors: Toshio
authors: T
authors: Kaneda
authors: A Hamid A
authors: AH
authors: Hadi
authors: Hiroshi
authors: H
authors: Morita
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D036701:Limonins / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D050356:Lipid Metabolism / Q000187:drug effects; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D036701:Limonins