title: B lymphocyte cytokine profile in a monozygotic twin pair discordant for nephrotic syndrome.
abstract: Nephrotic syndrome (NS) is the most common glomerular disorder of childhood and a leading cause of pediatric renal failure; however the etiology of NS remains largely unknown. Recent reports demonstrating that an anti-CD20 antibody can induce remission of NS strongly suggest a potentially novel role for B cells in NS pathogenesis. In this report, the authors investigated B cell cytokine profiles following in vitro stimulation in a monozygotic twin pair discordant for NS. The results revealed that clear differences in the cytokine profiles of B cells exist between the patient and the unaffected twin. This is the first report of altered B lymphocyte responses among a monozygotic twin pair that is discordant for NS. Future studies are needed to identify cytokine differences that track with NS relapse and/or NS response to therapy.
authors: Department of Cell Biology and Neuroscience, Rutgers University, B314 Nelson Hall, Piscataway, NJ, 08854, USA.
authors: Anibal
authors: A
authors: Valentin-Acevedo
authors: Lori Ruth
authors: LR
authors: Covey
authors: Sevgi
authors: S
authors: Gurkan
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002675:Child, Preschool; D018920:Coculture Techniques; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000276:immunology / Q000378:metabolism*; D014430:Twins, Monozygotic
chemical_list: D016207:Cytokines
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