title: Two cases of hepatitis B in patients with moderate to severe psoriasis with ustekinumab.
abstract: BACKGROUND
  Patients with psoriasis who are treated with systemic and biologic therapies may have an increased risk of infections, including hepatitis B virus (HBV). Cytokines that modulate CD4+ T cell subsets, including interleukin (IL)-12 and IL-23, have been suggested to play a role in the pathogenesis of HBV infection.
  
  
  OBJECTIVE
  To report the first known cases of acute HBV infection in 2 ustekinumab-treated patients with psoriasis from a phase 3 (PHOENIX 1) and a phase 4 (TRANSIT) study.
  
  
  RESULTS
  Both ustekinumab-treated patients generated an immune response toward HBV and experienced typical courses of infection, without progression to chronic HBV infection.
  
  
  CONCLUSIONS
  Continued monitoring of liver-related adverse events in clinical trials, registries, and spontaneous reporting from the postmarketing setting will further contribute to understanding the role of ustekinumab in viral hepatitis.
authors: Loyola University Chicago Stritch School of Medicine, Chicago, IL, USA.
authors: Daniel
authors: D
authors: Opel
authors: Afrodite
authors: A
authors: Economidi
authors: Daphne
authors: D
authors: Chan
authors: Yasmine
authors: Y
authors: Wasfi
authors: Sameer
authors: S
authors: Mistry
authors: Theognosia
authors: T
authors: Vergou
authors: Christina
authors: C
authors: Antoniou
authors: Howard
authors: H
authors: Sofen
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects* / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D001774:Blood Chemical Analysis; D017326:Clinical Trials, Phase III as Topic; D017327:Clinical Trials, Phase IV as Topic; D004279:DNA, Viral / Q000097:blood; D006509:Hepatitis B / Q000209:etiology*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D011565:Psoriasis / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D012306:Risk; D012867:Skin / Q000473:pathology; D000069549:Ustekinumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000069549:Ustekinumab