title: Early signs of autism in toddlers: a follow-up study in the Danish National Birth Cohort.
abstract: To identify possible early signs of autism spectrum disorder (ASD) within the Danish National Birth Cohort, we studied prospectively collected interviews from 76,441 mothers about their children's development and behaviour at 6 and 18 months. In Danish national registries, 720 children with ASD and 231 children with intellectual disability (ID) were identified. At 6 months, associations between early signs and ASD or ID were found only in few areas. At 18 months social, language, and motor skills were delayed, and suspicion of vision and hearing problems were increased for both groups. Signs distinguishing ASD from ID were unclear, and the positive predictive values regarding ASD were below 10 % for individual predictors and aggregated risk scores.
authors: Regional Centre for Child and Adolescent Psychiatry, Aarhus University Hospital, Harald Selmers Vej 66, 8240, Risskov, Denmark, sanne.lemcke@ps.rm.dk.
authors: Sanne
authors: S
authors: Lemcke
authors: Svend
authors: S
authors: Juul
authors: Erik T
authors: ET
authors: Parner
authors: Marlene B
authors: MB
authors: Lauritsen
authors: Poul
authors: P
authors: Thorsen
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003718:Denmark; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000523:psychology; D007804:Language Development; D008297:Male; D009048:Motor Skills
references: Autism. 2003 Jun;7(2):125-43
references: 12846383
references: J Pediatr Nurs. 2003 Dec;18(6):433-9
references: 15058541
references: J Child Psychol Psychiatry. 2010 Apr;51(4):432-58
references: 20085609
references: J Am Acad Child Adolesc Psychiatry. 2012 Mar;51(3):249-260.e25
references: 22365461
references: Am J Psychiatry. 2005 Jun;162(6):1133-41
references: 15930062
references: Dev Psychopathol. 2002 Spring;14(2):239-51
references: 12030690
references: J Dev Behav Pediatr. 2006 Apr;27(2 Suppl):S59-68
references: 16685187
references: Pediatrics. 2011 May;127(5):e1303-11
references: 21464190
references: Autism. 2013 Mar;17(2):133-46
references: 21610184
references: Pediatr Rev. 2012 Apr;33(4):172-4
references: 22474114
references: Scand J Public Health. 2011 Jul;39(7 Suppl):54-7
references: 21775352
references: J Am Acad Child Adolesc Psychiatry. 2010 Mar;49(3):256-66.e1-2
references: 20410715
references: J Autism Dev Disord. 2007 May;37(5):960-75
references: 17066310
references: Eur Child Adolesc Psychiatry. 2003 Jun;12(3):122-7
references: 12768459
references: J Autism Dev Disord. 2007 Feb;37(2):301-13
references: 17031450
references: Epidemiology. 2006 Jul;17(4):413-8
references: 16755269
references: Percept Mot Skills. 2008 Feb;106(1):259-69
references: 18459375
references: Eur Child Adolesc Psychiatry. 2006 Mar;15(2):71-8
references: 16477477
references: Pediatr Res. 2009 Jun;65(6):591-8
references: 19218885
references: J Autism Dev Disord. 2005 Jun;35(3):337-50
references: 16119475
references: Eur Child Adolesc Psychiatry. 1998 Sep;7(3):131-6
references: 9826299
references: J Autism Dev Disord. 2007 Jan;37(1):62-72
references: 17195921
references: Scand J Public Health. 2001 Dec;29(4):300-7
references: 11775787
references: Arch Gen Psychiatry. 2005 Aug;62(8):889-95
references: 16061766
references: J Autism Dev Disord. 2008 Apr;38(4):644-56
references: 17805956
references: J Child Psychol Psychiatry. 2006 Jun;47(6):629-38
references: 16712640
references: J Autism Dev Disord. 2007 Jan;37(1):12-24
references: 17211728
references: JAMA. 2003 Jan 1;289(1):49-55
references: 12503976
references: Scand J Public Health. 2011 Jul;39(7 Suppl):30-3
references: 21775347
references: J Autism Dev Disord. 2007 Jan;37(1):49-61
references: 17219058
references: Arch Pediatr Adolesc Med. 2008 Dec;162(12):1150-6
references: 19047542
references: Autism. 2009 Jul;13(4):357-74
references: 19535466
references: J Autism Dev Disord. 2010 Feb;40(2):139-48
references: 19728067
references: Dan Med Bull. 2006 Nov;53(4):441-9
references: 17150149
references: Nat Clin Pract Neurol. 2008 Mar;4(3):138-47
references: 18253102
references: Dev Psychopathol. 2008 Summer;20(3):775-803
references: 18606031
references: J Dev Behav Pediatr. 2006 Apr;27(2 Suppl):S79-87
references: 16685189