title: Effect of the oral vasopressin receptor antagonist tolvaptan on congestive cardiac failure in a child with restrictive cardiomyopathy.
abstract: Tolvaptan, an oral vasopressin receptor antagonist, was administered to a 6-year-old boy with advanced congestive cardiac failure due to restrictive cardiomyopathy. Slow up-titration of the tolvaptan improved the loop diuretic-resistant congestive cardiac failure without hypernatraemia, deterioration of vital signs, and significant complications. Tolvaptan could be useful and safe for children with severe congestive cardiac failure. It is necessary to accumulate clinical data on tolvaptan administration in children in order to determine the optimal method of administration.
authors: 1 Department of Adult Congenital Heart Disease, Chiba Cardiovascular Center, Ichihara, Chiba, Japan.
authors: Yoko
authors: Y
authors: Horibata
authors: 1 Department of Adult Congenital Heart Disease, Chiba Cardiovascular Center, Ichihara, Chiba, Japan.
authors: Tomoaki
authors: T
authors: Murakami
authors: 2 Department of Cardiology, Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan.
authors: Koichiro
authors: K
authors: Niwa
mesh_terms: D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines / Q000627:therapeutic use*; D002313:Cardiomyopathy, Restrictive / Q000150:complications / Q000188:drug therapy*; D002648:Child; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D000077602:Tolvaptan; D016896:Treatment Outcome
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines; D000077602:Tolvaptan