title: Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy--relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project).
abstract: Exposure of the general population to polycyclic aromatic hydrocarbons (PAH) is ubiquitous. The aim of this study was to analyze biomarkers associated with the uptake of PAH in 428 non-smoking women from Łodz (Poland), Viterbo (Italy), Belgrade (Serbia) and from the Pančevo area, where the petrochemical complex was destroyed by the air raids in 1999. Urinary excretion of PAH metabolites was lowest in Italian women, intermediary for Serbian and highest in Polish women, who predominantly excreted hydroxy phenanthrenes as metabolites of phenanthrene. Bulky DNA adduct levels were highest in Italian and Polish women. Genotype or PAH ambient air levels could not explain the dissimilarities between the study groups with respect to biomarker patterns, which probably reflected differences in life style-associated factors.
authors: Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden. Robertn65@telia.com
authors: Robert
authors: R
authors: Nilsson
authors: Ruža
authors: R
authors: Antić
authors: Andrea
authors: A
authors: Berni
authors: Gustav
authors: G
authors: Dallner
authors: Gerhard
authors: G
authors: Dettbarn
authors: Jolanta
authors: J
authors: Gromadzinska
authors: Gordana
authors: G
authors: Joksić
authors: Cecilia
authors: C
authors: Lundin
authors: Fabrizio
authors: F
authors: Palitti
authors: Gabriela
authors: G
authors: Prochazka
authors: Konrad
authors: K
authors: Rydzynski
authors: Dan
authors: D
authors: Segerbäck
authors: Pavel
authors: P
authors: Souček
authors: Michael
authors: M
authors: Tekle
authors: Albrecht
authors: A
authors: Seidel
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D001798:Blood Proteins / Q000032:analysis / Q000235:genetics; D018736:DNA Adducts / Q000097:blood; D004249:DNA Damage; D004032:Diet; D004785:Environmental Pollutants / Q000493:pharmacokinetics / Q000633:toxicity / Q000652:urine*; D005260:Female; D005638:Fruit / Q000737:chemistry; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D007558:Italy; D008875:Middle Aged; D011044:Poland; D011084:Polycyclic Aromatic Hydrocarbons / Q000493:pharmacokinetics / Q000633:toxicity / Q000652:urine*; D055771:Serbia; D014675:Vegetables / Q000737:chemistry
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D018736:DNA Adducts; D004785:Environmental Pollutants; D011084:Polycyclic Aromatic Hydrocarbons