title: [Neurotoxic effects of cobalt: an open question].
abstract: Increased cobalt levels have been associated with neurological diseases (hand tremor, incoordination, cognitive decline, depression, vertigo, hearing loss and visual changes) in addition to "classic" and known cardiac diseases (arrhythmias and cardiomyopathies) and allergic or endocrine symptoms. Cobalt neurotoxicity is reported in isolated cases: old occupational or iatrogenic exposures and more recent releases of metallic ions by prosthesis. The studies of these cases have revealed a typical symptomatology of cobalt probably due to its ability to induce oxidative stress and mitochondrial alterations.
authors: Dipartimento di Medicina Sperimentale e Applicata, Sezione di Medicina del Lavoro e Igiene Industriale, Università degli Studi di Brescia, P.le Spedali. Civili 1. 25123 Brescia. catalani@med.unibs.it
authors: S
authors: S
authors: Catalani
authors: P
authors: P
authors: Apostoli
mesh_terms: D003035:Cobalt / Q000633:toxicity*; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D009784:Occupational Diseases / Q000139:chemically induced*
chemical_list: D003035:Cobalt