title: Diagnostic ability of spectral-domain versus time-domain optical coherence tomography in preperimetric glaucoma.
abstract: OBJECTIVE
  To evaluate and compare the diagnostic abilities of the speckle noise-reduced spectral-domain optical coherence tomography (SD-OCT; Spectralis OCT) and time-domain optical coherence tomography (TD-OCT; Stratus OCT) to detect localized retinal nerve fiber layer (RNFL) defects in patients with preperimetric open-angle glaucoma.
  
  
  METHODS
  Thirty-five eyes of 35 preperimetric glaucoma patients with localized RNFL defects and 72 normal control eyes were scanned using SD-OCT and TD-OCT. Areas under the receiver-operating characteristic curves (AUROCs), and the sensitivity and specificity for detecting localized RNFL defects based on the internal normative database of each device were calculated and compared.
  
  
  RESULTS
  The AUROC for the best parameter from SD-OCT (inferotemporal sector, AUROC=0.940) was significantly higher than that of TD-OCT (7 o'clock sector, AUROC=0.881; P=0.009). The sensitivity of the SD-OCT parameters ranged from 18.9% to 83.8% and that of the TD-OCT parameters ranged from 5.4% to 54.1%, with the criterion of abnormal at the 5% level. The highest sensitivity of the SD-OCT was found with the temporal-superior-nasal-inferior-temporal thickness graph abnormal at the 5% level, which had a specificity of 90.3%. On the basis of temporal-superior-nasal-inferior-temporal thickness graphs, SD-OCT was more sensitive (P=0.001) for detection of preperimetric RNFL defects than TD-OCT at a comparable specificity (P=0.227).
  
  
  CONCLUSIONS
  Speckle noise-reduced SD-OCT is better able to detect preperimetric localized RNFL defect(s) than TD-OCT.
authors: *Department of Ophthalmology, Seoul National University College of Medicine †Department of Ophthalmology, Seoul National University Hospital ∥Department of Ophthalmology, Seoul National University Boramae Hospital, Seoul ‡Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea §Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla, CA.
authors: Jin Wook
authors: JW
authors: Jeoung
authors: Tae-Woo
authors: TW
authors: Kim
authors: Robert N
authors: RN
authors: Weinreb
authors: Seok Hwan
authors: SH
authors: Kim
authors: Ki Ho
authors: KH
authors: Park
authors: Dong Myung
authors: DM
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012680:Sensitivity and Specificity; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods; D014065:Tonometry, Ocular; D058609:Visual Field Tests; D014794:Visual Fields; D055815:Young Adult