title: Property-based design in the optimisation of benzamide glucokinase activators: from hit to clinic.
authors: Cardiovascular and Gastrointestinal Innovative Medicines, AstraZeneca, Macclesfield, UK.
authors: Darren
authors: D
authors: McKerrecher
authors: Michael J
authors: MJ
authors: Waring
mesh_terms: D000818:Animals; D001549:Benzamides / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000201:enzymology; D015195:Drug Design; D004789:Enzyme Activation / Q000187:drug effects; D005941:Glucokinase / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D008958:Models, Molecular
chemical_list: D001549:Benzamides; D007004:Hypoglycemic Agents; D005941:Glucokinase