title: Tumor blood flow from arterial spin labeling perfusion MRI: a key parameter in distinguishing high-grade gliomas from primary cerebral lymphomas, and in predicting genetic biomarkers in high-grade gliomas.
abstract: OBJECTIVE
  To evaluate the usefulness of pseudo-continuous arterial spin labeling (pCASL) imaging in differentiating high-grade gliomas from lymphomas and in noninvasively predicting genetic biomarkers in high-grade gliomas.
  
  
  METHODS
  Twelve glioblastoma multiforme (GBM), 3 anaplastic astrocytoma (AA), 5 recurred GBM, and 9 lymphoma patients underwent conventional MR and pCASL imaging. On pCASL perfusion map, mean absolute tumor blood flow (mTBF) was calculated from five regions of interest (ROIs) within the enhancing portion of the tumor. Relative TBF (rTBF = mTBF/mBFgm × 100) was also calculated. mTBF and rTBF of high-grade gliomas and lymphomas were compared using unpaired Student's t-test and receiver operating characteristic (ROC) analysis. Additionally, the association of TBF and six immunohistochemically confirmed genetic biomarkers was analyzed by Pearson correlation analysis in the group of high-grade gliomas.
  
  
  RESULTS
  Both mTBF and rTBF of the high-grade gliomas were significantly higher than those of the lymphomas: 92.1 ± 34.7 versus 53.6 ± 30.5 mL/min/100 mg (P = 0.008) and 182.3 ± 69.5 versus 92.5 ± 44.9 (P = 0.002), respectively. Only epidermal growth factor receptor (EGFR) expression status showed a significant positive correlation with mTBF(P = 0.015) and rTBF(P = 0.007).
  
  
  CONCLUSIONS
  pCASL imaging may facilitate differentiation of high-grade gliomas from lymphomas and prediction of EGFR expression status in high-grade gliomas.
authors: Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
authors: Roh-Eul
authors: RE
authors: Yoo
authors: Seung Hong
authors: SH
authors: Choi
authors: Hye Rim
authors: HR
authors: Cho
authors: Tae Min
authors: TM
authors: Kim
authors: Se-Hoon
authors: SH
authors: Lee
authors: Chul-Kee
authors: CK
authors: Park
authors: Sung-Hye
authors: SH
authors: Park
authors: Il Han
authors: IH
authors: Kim
authors: Tae Jin
authors: TJ
authors: Yun
authors: Ji-Hoon
authors: JH
authors: Kim
authors: Chul-Ho
authors: CH
authors: Sohn
authors: Moon Hee
authors: MH
authors: Han
authors: Kee Hyun
authors: KH
authors: Chang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000098:blood supply / Q000175:diagnosis*; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000098:blood supply / Q000175:diagnosis*; D066246:ErbB Receptors / Q000378:metabolism; D005909:Glioblastoma / Q000098:blood supply / Q000175:diagnosis*; D005910:Glioma / Q000098:blood supply / Q000175:diagnosis*; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010477:Perfusion; D012372:ROC Curve; D012008:Recurrence; D012189:Retrospective Studies; D013113:Spin Labels
chemical_list: D014408:Biomarkers, Tumor; D013113:Spin Labels; D066246:ErbB Receptors
keywords: genetic biomarkers; high-grade gliomas; imaging biomarker; primary cerebral lymphomas; pseudo-continuous arterial spin labeling imaging