title: Updating and curating metabolic pathways of TB.
abstract: The sequencing of complete genomes has accelerated biomedical research by providing information about the overall coding capacity of bacterial chromosomes. The original TB annotation resulted in putative functional assignment of ∼60% of the genes to specific metabolic functions, however, the other 40% of the encoded ORFs where annotated as conserved hypothetical proteins, hypothetical proteins or encoding proteins of unknown function. The TB research community is now at the beginning of the next phases of post-genomics; namely reannotation and functional characterization by targeted experimentation. Arguably, this is the most significant time for basic microbiology in recent history. To foster basic TB research, the Tuberculosis Community Annotation Project (TBCAP) jamboree exercise began the reannotation effort by providing additional information for previous annotations, and refining and substantiating the functional assignment of ORFs and genes within metabolic pathways. The overall goal of the TBCAP 2012 exercise was to gather and compile various data types and use this information with oversight from the scientific community to provide additional information to support the functional annotations of encoding genes. Another objective of this effort was to standardize the publicly accessible Mycobacterium tuberculosis reference sequence and its annotation. The greatest benefit of functional annotation information of genome sequence is that it fuels TB research for drug discovery, diagnostics, vaccine development and epidemiology.
authors: Colorado State University, Fort Collins, CO, USA. Richard.slayden@colostate.edu
authors: Richard A
authors: RA
authors: Slayden
authors: Mary
authors: M
authors: Jackson
authors: Jeremy
authors: J
authors: Zucker
authors: Melissa V
authors: MV
authors: Ramirez
authors: Clinton C
authors: CC
authors: Dawson
authors: Rebecca
authors: R
authors: Crew
authors: Nicole S
authors: NS
authors: Sampson
authors: Suzanne T
authors: ST
authors: Thomas
authors: Neema
authors: N
authors: Jamshidi
authors: Peter
authors: P
authors: Sisk
authors: Ron
authors: R
authors: Caspi
authors: Dean C
authors: DC
authors: Crick
authors: Michael R
authors: MR
authors: McNeil
authors: Martin S
authors: MS
authors: Pavelka
authors: Michael
authors: M
authors: Niederweis
authors: Axel
authors: A
authors: Siroy
authors: Valentina
authors: V
authors: Dona
authors: Johnjoe
authors: J
authors: McFadden
authors: Helena
authors: H
authors: Boshoff
authors: Jocelyne M
authors: JM
authors: Lew
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000502:physiology; D019295:Computational Biology / Q000379:methods; D005798:Genes, Bacterial; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000378:metabolism*; D016366:Open Reading Frames / Q000235:genetics; D014376:Tuberculosis / Q000378:metabolism*
chemical_list: D001425:Bacterial Outer Membrane Proteins
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