title: Cellular immune responses in multiple sclerosis patients treated with interferon-beta.
abstract: We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders.
authors: Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors: M F
authors: MF
authors: Bustamante
authors: J
authors: J
authors: Rio
authors: Z
authors: Z
authors: Castro
authors: A
authors: A
authors: Sánchez
authors: X
authors: X
authors: Montalban
authors: M
authors: M
authors: Comabella
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016207:Cytokines / Q000032:analysis; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000276:immunology / Q000627:therapeutic use*; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D016207:Cytokines; D016899:Interferon-beta
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