title: Intrathecal activation as a typical immune response within the central nervous system in angiostrongyliasis.
abstract: Angiostrongylus cantonensis is a zoonotic pathogen that occasionally causes human angiostrongyliasis; its main clinical manifestation is eosinophilic meningitis. This report defines the concept of intrathecal activation of complement as evidence of intrathecal synthesis of major immunoglobulins during this disease. Details are presented of the activation of complement system components in cerebrospinal fluid, and their application to our understanding of this tropical disease, which is emerging in the Western hemisphere. Intrathecal synthesis of at least one of the major immunoglobulins and a wide spectrum of patterns may be observed. Although intrathecal synthesis of C3c is always present, C4 intrathecal synthesis does not occur in every patient. The diversity of intrathecal synthesis and activation of the different complement pathways enables their division into three variant groups (A, B, and C). Variant group A includes the classical and/or lectin pathway and involves two or more major immunoglobulins with C3 and C4 intrathecal synthesis. Variant group B involves C4 in cerebrospinal fluid that comes from blood in the intrathecal activation of the classical pathway. Variant group C includes the alternative pathway.
authors: Central Laboratory of Cerebrospinal Fluid, Faculty of Medical Sciences Dr. Miguel Enriquez, Havana Medical Sciences University, Havana, Cuba. barbara.padilla@infomed.sld.cu
authors: Barbara
authors: B
authors: Padilla-Docal
authors: Ivonne
authors: I
authors: Iglesias-González
authors: Raisa
authors: R
authors: Bu-Coifiu-Fanego
authors: Carmen Aleida
authors: CA
authors: Socarrás-Hernández
authors: Alberto Juan
authors: AJ
authors: Dorta-Contreras
mesh_terms: D017185:Angiostrongylus cantonensis / Q000302:isolation & purification / Q000472:pathogenicity; D000818:Animals; D002490:Central Nervous System / Q000276:immunology* / Q000469:parasitology*; D015932:Complement C3c / Q000134:cerebrospinal fluid / Q000276:immunology; D015935:Complement C4b / Q000134:cerebrospinal fluid / Q000276:immunology; D004802:Eosinophilia / Q000134:cerebrospinal fluid / Q000276:immunology / Q000469:parasitology; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid / Q000276:immunology; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000276:immunology / Q000469:parasitology; D010446:Peptide Fragments / Q000134:cerebrospinal fluid / Q000276:immunology; D017206:Strongylida Infections / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000469:parasitology
chemical_list: D007136:Immunoglobulins; D010446:Peptide Fragments; C033860:complement C4c; D015932:Complement C3c; D015935:Complement C4b
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