title: Bovine lactoferrin reduces visceral fat and liver triglycerides in ICR mice.
abstract: Lactoferrin (LF) is a multi-functional glycoprotein found in milk. In a previous clinical trial, we showed that enteric-coated bovine LF (bLF) tablets could reduce visceral fat accumulation. We also showed that bLF had anti-adipogenic activity in vitro. However, the mechanisms responsible for these phenomena remain unclear. In this study, we established an animal model of visceral fat reduction via oral bLF administration. We used gastric intubation to ensure that LF was absorbed in the small intestine. bLF administration for 4 weeks significantly reduced mesenteric fat tissue (P < 0.05) and hepatic triglyceride levels (P < 0.01). Furthermore, these two outcomes were positively correlated (R = 0.581, P < 0.05). Overall, these findings suggest that bLF affects mesenteric adipocytes and fatty acid metabolism in the liver.
authors: Research and Development Headquarters, Lion Corporation, Kanagawa 256-0811, Japan. smorichi@lion.co.jp
authors: Satoru
authors: S
authors: Morishita
authors: Tomoji
authors: T
authors: Ono
authors: Chikako
authors: C
authors: Fujisaki
authors: Yasuharu
authors: Y
authors: Ishihara
authors: Michiaki
authors: M
authors: Murakoshi
authors: Hisanori
authors: H
authors: Kato
authors: Masashi
authors: M
authors: Hosokawa
authors: Kazuo
authors: K
authors: Miyashita
authors: Keikichi
authors: K
authors: Sugiyama
authors: Hoyoku
authors: H
authors: Nishino
mesh_terms: D000284:Administration, Oral; D000818:Animals; D007408:Intestinal Absorption; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D007781:Lactoferrin / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D014280:Triglycerides; D007781:Lactoferrin