title: Association between plasminogen activator inhibitor-1 -675 4G/5G polymorphism and sepsis: a meta-analysis.
abstract: BACKGROUND
  Several studies have evaluated the association between plasminogen activator inhibitor-1 (PAI-1) -675 4G/5G polymorphism and sepsis in different populations. However, the available results are conflicting.
  
  
  METHODS
  A search of Pubmed and EMBASE databases was performed to identify relevant studies for inclusion in the meta-analysis. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were determined using a random-effects model.
  
  
  RESULTS
  Twelve case-control studies and three cohort studies were included. Overall, a significant association between 4G/5G polymorphism and sepsis risk was observed for 4G/4G vs. 4G/5G +5G/5G (OR = 1.30, 95% CI 1.08-1.56, P = 0.006). In addition, there was a significant association between PAI-1 4G/5G polymorphism and sepsis-related mortality (OR = 1.72, 95% CI 1.27-2.33, P = 0.0005). In subgroup analyses, increased sepsis risk and mortality risk were found in Caucasians and in patients with sepsis.
  
  
  CONCLUSIONS
  This meta-analysis suggested that the PAI-1 -675 4G/5G polymorphism was a risk factor for sepsis and sepsis mortality.
authors: Department of Respiratory Medicine, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
authors: Li
authors: L
authors: Li
authors: Wei
authors: W
authors: Nie
authors: Hongfeng
authors: H
authors: Zhou
authors: Weifeng
authors: W
authors: Yuan
authors: Weifeng
authors: W
authors: Li
authors: Wenjie
authors: W
authors: Huang
mesh_terms: D056726:Genetic Association Studies; D006801:Humans; D016017:Odds Ratio; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D018805:Sepsis / Q000235:genetics* / Q000401:mortality
chemical_list: D017395:Plasminogen Activator Inhibitor 1
references: Crit Care Med. 2007 May;35(5):1244-50
references: 17414736
references: Crit Care. 2009;13(2):210
references: 19439056
references: Thromb Res. 2006;118(2):205-12
references: 16009400
references: Chest. 1992 Mar;101(3):816-23
references: 1531791
references: Circulation. 2003 May 20;107(19):2422-7
references: 12719278
references: Clin Infect Dis. 2005 Nov 15;41 Suppl 7:S453-8
references: 16237647
references: Crit Care Med. 2012 May;40(5):1618-26
references: 22511139
references: PLoS One. 2012;7(7):e42062
references: 22844542
references: BMC Infect Dis. 2007 Sep 18;7:108
references: 17877801
references: Thromb Haemost. 1996 Jun;75(6):902-7
references: 8822584
references: Stat Med. 2005 May 15;24(9):1291-306
references: 15568190
references: J Infect Dev Ctries. 2012 Jul 23;6(7):555-62
references: 22842942
references: J Infect Dis. 1996 May;173(5):1148-56
references: 8627066
references: Crit Care Med. 2003 Dec;31(12):2788-93
references: 14668616
references: Br J Haematol. 2004 Apr;125(1):12-23
references: 15015963
references: Maturitas. 2004 Apr 15;47(4):305-14
references: 15063484
references: Cytokine. 2012 Dec;60(3):849-55
references: 23017230
references: Thromb Res. 2012 Mar;129(3):290-5
references: 22061311
references: Genet Med. 2005 Jan;7(1):13-20
references: 15654223
references: Zhonghua Yi Xue Za Zhi. 2005 Sep 7;85(34):2404-7
references: 16321247
references: Crit Care Med. 2009 Jan;37(1):192-201, e1-3
references: 19050632
references: Clin Sci (Lond). 1995 May;88(5):587-94
references: 7614818
references: Lancet. 1999 Aug 14;354(9178):556-60
references: 10470700
references: Eur J Pediatr. 2005 Aug;164(8):486-90
references: 15843979
references: Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1851-5
references: 7892190
references: Int J Hematol. 2006 Dec;84(5):398-405
references: 17189219
references: Lancet. 2001 Apr 7;357(9262):1096-7
references: 11297964
references: BMJ. 1997 Sep 13;315(7109):629-34
references: 9310563
references: Mediterr J Hematol Infect Dis. 2010 Aug 13;2(3):e2010024
references: 21415977
references: Crit Care. 2010;14(2):R79
references: 20429897
references: Lancet. 1999 Aug 14;354(9178):561-3
references: 10470701
references: Intensive Care Med. 2006 Nov;32(11):1706-12
references: 16957907
references: J Biol Chem. 1993 May 25;268(15):10739-45
references: 8388372
references: Intensive Care Med. 2007 Aug;33(8):1354-62
references: 17541549
references: Thromb Haemost. 1999 Aug;82(2):165-74
references: 10605701
references: Thromb Res. 2010 Apr;125(4):367-9
references: 19410276
references: Clin Appl Thromb Hemost. 2006 Jan;12(1):47-54
references: 16444434