title: Expression and distribution of sialic acid influenza virus receptors in wild birds.
abstract: Avian influenza (AI) viruses have been detected in more than 105 wild bird species from 12 different orders but species-related differences in susceptibility to AI viruses exist. Expression of α2,3-linked (avian-type) and α2,6-linked (human-type) sialic acid (SA) influenza virus receptors in tissues is considered one of the determinants of the host range and tissue tropism of influenza viruses. We investigated the expression of these SA receptors in 37 wild bird species from 11 different orders by lectin histochemistry. Two isoforms of Maackia amurensis (MAA) lectin, MAA1 and MAA2, were used to detect α2,3-linked SA, and Sambucus nigra lectin was used to detect α2,6-linked SA. All species evaluated expressed α2,3-linked and α2,6-linked SA receptors in endothelial cells and renal tubular epithelial cells. Both α2,3-linked and α-2,6-linked SA receptors were expressed in respiratory and intestinal tract tissues of aquatic and terrestrial wild bird species from different taxa, but differences in SA expression and in the predominant isoform of MAA lectin bound were observed. With a few possible exceptions, these observed differences were not generally predictive of reported species susceptibility to AI viruses based on published experimental and field data.
authors: Department of Pathology, University of Georgia, 501 DW Brooks Drive, Athens, GA 30602, USA.
authors: M
authors: M
authors: França
authors: D E
authors: DE
authors: Stallknecht
authors: E W
authors: EW
authors: Howerth
mesh_terms: D000818:Animals; D001717:Birds; D042783:Endothelial Cells / Q000378:metabolism / Q000821:virology; D004847:Epithelial Cells / Q000378:metabolism / Q000821:virology; D058507:Host Specificity; D009980:Influenza A virus / Q000502:physiology*; D005585:Influenza in Birds / Q000378:metabolism* / Q000821:virology; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000821:virology; D037102:Lectins / Q000378:metabolism*; D029901:Maackia / Q000378:metabolism; D009928:Organ Specificity; D020033:Protein Isoforms; D011956:Receptors, Cell Surface / Q000302:isolation & purification / Q000378:metabolism*; D011991:Receptors, Virus / Q000302:isolation & purification / Q000378:metabolism*; D012137:Respiratory System / Q000378:metabolism / Q000821:virology; D013045:Species Specificity
chemical_list: D037102:Lectins; D020033:Protein Isoforms; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; C092488:sialic acid receptor
references: Virology. 1997 Jun 23;233(1):224-34
references: 9201232
references: Virol J. 2010 Jan 12;7:5
references: 20067630
references: Emerg Infect Dis. 2008 Jan;14(1):136-42
references: 18258093
references: Avian Pathol. 2010 Oct;39(5):411-8
references: 20954019
references: Vet Pathol. 2003 Jan;40(1):14-24
references: 12627709
references: Science. 2006 Apr 21;312(5772):384-8
references: 16627734
references: Avian Pathol. 2009 Aug;38(4):263-6
references: 19937510
references: Nature. 1983 Jul 7-13;304(5921):76-8
references: 6191220
references: PLoS One. 2009 Oct 22;4(10):e7555
references: 19847294
references: Nature. 2006 Mar 23;440(7083):435-6
references: 16554799
references: Emerg Infect Dis. 2007 Nov;13(11):1720-4
references: 18217557
references: Emerg Infect Dis. 2006 Nov;12(11):1663-70
references: 17283615
references: Virology. 2005 Apr 10;334(2):276-83
references: 15780877
references: J Mol Genet Med. 2009 Jan 16;3(1):143-51
references: 19565022
references: Vector Borne Zoonotic Dis. 2004 Fall;4(3):177-89
references: 15631061
references: Virology. 2006 Mar 15;346(2):278-86
references: 16325879
references: Respir Res. 2007 Oct 25;8:73
references: 17961210
references: Avian Dis. 1995 Jan-Mar;39(1):74-84
references: 7794194
references: J Wildl Dis. 2010 Oct;46(4):1284-9
references: 20966281
references: PLoS One. 2011;6(9):e24155
references: 21909418
references: Avian Pathol. 2008 Aug;37(4):393-7
references: 18622855
references: Biol Pharm Bull. 2005 Mar;28(3):399-408
references: 15744059
references: J Wildl Dis. 2008 Apr;44(2):351-61
references: 18436667
references: Vet Res Commun. 1988;12(2-3):125-41
references: 3055662