title: Confirmatory factor analysis of the Neuropsychological Assessment Battery of the LADIS study: a longitudinal analysis.
abstract: Age-related white matter changes have been associated with cognitive functioning, even though their role is not fully understood. This work aimed to test a 3-factor model of the neuropsychological assessment battery and evaluate how the model fit the data longitudinally. Confirmatory factor analysis (CFA) was used to investigate the dimensions of a structured set of neuropsychological tests administered to a multicenter, international sample of independent older adults (LADIS study). Six hundred and thirty-eight older adults completed baseline neuropsychological, clinical, functional and motor assessments, which were repeated each year for a 3-year follow-up. CFA provided support for a 3-factor model. These factors involve the dimensions of executive functions, memory functions, and speed and motor control abilities. Performance decreased in most neuropsychological measures. Results showed that executive functioning, memory and speed of motor abilities are valid latent variables of neuropsychological performance among older adults, and that this structure is relatively consistent longitudinally, even though performance decreases with time.
authors: Instituto Universitário de Lisboa (ISCTE-IUL), CIS-IUL, Lisbon, Portugal. carla.moleiro@iscte.pt
authors: Carla
authors: C
authors: Moleiro
authors: Sofia
authors: S
authors: Madureira
authors: Ana
authors: A
authors: Verdelho
authors: José M
authors: JM
authors: Ferro
authors: Anna
authors: A
authors: Poggesi
authors: Hugues
authors: H
authors: Chabriat
authors: Timo
authors: T
authors: Erkinjuntti
authors: Franz
authors: F
authors: Fazekas
authors: Michael
authors: M
authors: Hennerici
authors: John
authors: J
authors: O'Brien
authors: Leonardo
authors: L
authors: Pantoni
authors: Emilia
authors: E
authors: Salvadori
authors: Philip
authors: P
authors: Scheltens
authors: Marieke C
authors: MC
authors: Visser
authors: Lars-Olof
authors: LO
authors: Wahlund
authors: Gunhild
authors: G
authors: Waldemar
authors: Anders
authors: A
authors: Wallin
authors: Domenico
authors: D
authors: Inzitari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000523:psychology*; D056344:Executive Function; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008568:Memory; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009483:Neuropsychological Tests; D011597:Psychomotor Performance