title: [A 44-year-old woman with hereditary nonpolyposis colon carcinoma: screening examinations for non-colonic tumors].
abstract: A 44-year-old woman presented in March 2010 for surveillance esophagogastroduodenoscopy (EGD). In October 2004, rectal cancer had been diagnosed and treated by resection of the rectum with adjuvant chemotherapy. A diagnosis of hereditary nonpolyposis colon carcinoma (HNPCC) was established on the basis of the Amsterdam II criteria. Due to a lack of clear guidelines we decided to perform annual systematic surveillance examinations of the stomach and the most frequent tumor manifestations. Until 2009, extracolonic tumors were not observed in the patient. In March 2010, EGD showed a discrete erosive lesion in the gastric antrum, which was biopsied. Most notably, the histopathological examination revealed a poorly differentiated mucinous adenocarcinoma. Due to the poor differentiation, we decided against technically possible, endoscopic resection. The patient underwent subtotal gastrectomy and is still doing fine 28 months after surgery. This case prompted us to evaluate our surveillance approach in HNPCC patients and to review the literature.
authors: I. Medizinische Klinik, Zentrum für Innere Medizin, Universitätsklinikum Hamburg, Martinistr. 52, 20246, Hamburg, Deutschland. j.holzhueter@uke.de
authors: J
authors: J
authors: Holzhüter
authors: T
authors: T
authors: Rösch
authors: A
authors: A
authors: Block
authors: A W
authors: AW
authors: Lohse
authors: S
authors: S
authors: Lüth
mesh_terms: D000328:Adult; D003110:Colonic Neoplasms / Q000175:diagnosis*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000556:secondary*
references: Gut. 2010 May;59(5):666-89
references: 20427401
references: J Clin Pathol. 2012 Apr;65(4):352-6
references: 22287689
references: Gastroenterology. 2010 Feb;138(2):487-92
references: 19900449
references: JAMA. 2005 Apr 27;293(16):1979-85
references: 15855431
references: Lancet Oncol. 2009 Apr;10(4):400-8
references: 19341971
references: J Clin Oncol. 2006 Sep 10;24(26):4285-92
references: 16908935
references: Clin Genet. 2009 Jul;76(1):1-18
references: 19659756
references: J Clin Oncol. 2001 Oct 15;19(20):4074-80
references: 11600610
references: J Med Genet. 2007 Jun;44(6):353-62
references: 17327285
references: JAMA. 2006 Sep 27;296(12):1507-17
references: 17003399