title: Cytokine profiles in children with primary Epstein-Barr virus infection.
abstract: Primary Epstein-Barr virus (EBV) infection causes infectious mononucleosis and hemophagocytic lymphohistiocytosis (HLH) in children, where EBV infects B and CD8(+) T cells, respectively. We measured pro-inflammatory and anti-inflammatory cytokines in both diseases. Significantly higher concentrations of various mediators, including interferon-γ, neopterin, interleukin (IL)-6, IL-10, IL-18, and heme oxygenase-1, were observed in EBV-HLH. Because of their similarity to the profile of familial HLH, this profile was likely a consequence of HLH, but not ectopic infection. TNF-α levels were elevated in both diseases. Elevation of those mediators may contribute to the disease pathogenesis of EBV-HLH by activating and inhibiting host immune responses.
authors: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. taizo@staff.kanazawa-u.ac.jp
authors: Taizo
authors: T
authors: Wada
authors: Masahiro
authors: M
authors: Muraoka
authors: Tadafumi
authors: T
authors: Yokoyama
authors: Tomoko
authors: T
authors: Toma
authors: Hirokazu
authors: H
authors: Kanegane
authors: Akihiro
authors: A
authors: Yachie
mesh_terms: D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D020031:Epstein-Barr Virus Infections / Q000097:blood* / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D016207:Cytokines