title: Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b]pyridines as soluble guanylate cyclase stimulators.
abstract: Novel guanylate cyclase stimulators are disclosed. Design, synthesis, SAR, and pharmacological profile of the compounds are discussed.
authors: Bayer Pharma AG, Global Drug Discovery, Medicinal Chemistry Wuppertal, D-42096 Wuppertal, Germany. nils.griebenow@bayer.com
authors: Nils
authors: N
authors: Griebenow
authors: Hartmut
authors: H
authors: Schirok
authors: Joachim
authors: J
authors: Mittendorf
authors: Alexander
authors: A
authors: Straub
authors: Markus
authors: M
authors: Follmann
authors: Johannes-Peter
authors: JP
authors: Stasch
authors: Andreas
authors: A
authors: Knorr
authors: Karl-Heinz
authors: KH
authors: Schlemmer
authors: Gorden
authors: G
authors: Redlich
mesh_terms: D000818:Animals; D006162:Guanylate Cyclase / Q000737:chemistry / Q000378:metabolism*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship
chemical_list: D011720:Pyrazoles; D011725:Pyridines; D006162:Guanylate Cyclase