title: Interaction of insulin-like growth factor-binding protein 2 with α2-macroglobulin in the circulation.
abstract: Insulin-like growth factors (IGFs) play active role in mitogenic and metabolic processes. In the peripheral circulation, they are mostly bound to specific IGF-binding proteins (IGFBPs). Proteolysis of IGFBPs releases free, active IGFs. IGFBP-2 is the second most abundant of the six binding proteins and its concentration increases in catabolic states. The possible interaction between IGFBP-2 and other proteins in the circulation was investigated in this study. Our results showed that IGFBP-2 associates with α2-macroglobulin (α2M), a protease inhibitor. Formation of IGFBP-2/α2M complexes most likely contributes to the regulation of IGFBP-2 proteolysis and, thus, the activity of IGFs.
authors: Institute for the Application of Nuclear Energy, INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia. milos@inep.co.rs
authors: Miloš
authors: M
authors: Šunderić
authors: Goran
authors: G
authors: Miljuš
authors: Olgica
authors: O
authors: Nedić
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D000511:alpha-Macroglobulins / Q000378:metabolism*
chemical_list: D018971:Insulin-Like Growth Factor Binding Protein 2; D000511:alpha-Macroglobulins
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