title: Serum and saliva levels of ischemia-modified albumin in patients with acute myocardial infarction.
abstract: OBJECTIVE
  Ischemia-modified albumin (IMA) is a novel marker for diagnosis of myocardial ischemia and it is considered as a serum marker. The aim of the study was to evaluate salivary IMA levels in patients with acute myocardial infarction (AMI) and to determine the relation between serum and salivary IMA levels.
  
  
  METHODS
  A total of 60 patients with AMI and 40 control subjects who are age and sex matched with AMI group were included in our study. The diagnosis of AMI was based on the WHO classification criteria. All patients underwent the clinical assessment, consisting of electrocardiography, and serum cardiac markers. Serum and salivary IMA levels were measured at the first and second days of AMI by using a colorimetric method.
  
  
  RESULTS
  Serum IMA levels were significantly higher in the first and second day of AMI patients, however, salivary IMA levels were significantly higher in the first day of AMI patients compared to the control (P < 0.05). There was a positive correlation between salivary IMA levels and serum IMA levels both in the first and second day of AMI patients (r = 0.298, P < 0.05; r = 0.319, P < 0.05, respectively).
  
  
  CONCLUSIONS
  We concluded that salivary IMA levels at the first day of AMI could be used as an alternative marker to serum IMA levels for diagnosis of AMI.
authors: Department of Biochemistry, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey. aysuntoker@gmail.com
authors: Aysun
authors: A
authors: Toker
authors: Alpay
authors: A
authors: Aribas
authors: F Hümeyra
authors: FH
authors: Yerlikaya
authors: Erkan
authors: E
authors: Tasyurek
authors: Kürşat
authors: K
authors: Akbuğa
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry*; D012709:Serum Albumin / Q000032:analysis*; D000075462:Serum Albumin, Human; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
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