title: Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells.
abstract: Three new pyrrole oligoglycosides, astebatheriosides A-C (1-3), and a new furan oligoglycoside, astebatherioside D (4), were isolated from the starfish Asterina batheri by various chromatographic methods. Their structures were elucidated by spectroscopic and chemical methods. Compounds 2, 3, and 4 moderately inhibited IL-12 p40 production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) with IC50 values of 36.4, 31.6, and 22.8μM, respectively.
authors: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam; College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors: Nguyen Phuong
authors: NP
authors: Thao
authors: Le Duc
authors: le D
authors: Dat
authors: Ninh Thi
authors: NT
authors: Ngoc
authors: Vu Anh
authors: VA
authors: Tu
authors: Tran Thi Hong
authors: TT
authors: Hanh
authors: Phan Thi Thanh
authors: PT
authors: Huong
authors: Nguyen Xuan
authors: NX
authors: Nhiem
authors: Bui Huu
authors: BH
authors: Tai
authors: Nguyen Xuan
authors: NX
authors: Cuong
authors: Nguyen Hoai
authors: NH
authors: Nam
authors: Pham Van
authors: PV
authors: Cuong
authors: Seo Young
authors: SY
authors: Yang
authors: Sohyun
authors: S
authors: Kim
authors: Doobyeong
authors: D
authors: Chae
authors: Young-Sang
authors: YS
authors: Koh
authors: Phan Van
authors: PV
authors: Kiem
authors: Chau Van
authors: CV
authors: Minh
authors: Young Ho
authors: YH
authors: Kim
mesh_terms: D000818:Animals; D047288:Asterina / Q000737:chemistry*; D001854:Bone Marrow Cells / Q000166:cytology; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D005663:Furans / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D053762:Interleukin-12 Subunit p40 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011758:Pyrroles / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D005663:Furans; D006027:Glycosides; D053762:Interleukin-12 Subunit p40; D015850:Interleukin-6; D008070:Lipopolysaccharides; D011758:Pyrroles; D014409:Tumor Necrosis Factor-alpha; C039281:furan