title: [The regeneratory potential of platelet in local brain inflammation under microgravity].
abstract: A hemorrhagic stroke model that provides the long-term presence of test materials in the focus has been constructed. A lesion is induced in the motor cerebral cortical region. The lesion location and locomotor dysfunction are reproducible. The presence of platelets in the focus reduces the extent and volume of hemorrhages, increases the number and diameter of newly formed vessels, and attracts a macrophage population not found in the control, which is identified from green granules and perivascular location. Motor function is restored more rapidly than in the control. The impact of microgravity is opposite to that of platelets. There are increases in blood congestion, hemorrhage area and postoperative mortality and a reduction in the population of macrophages with green granules. No motor function recovery was observed during a 7-day follow-up.
authors: S V
authors: SV
authors: Komissarova
authors: I P
authors: IP
authors: Dubrovin
authors: S A
authors: SA
authors: Turygin
authors: A A
authors: AA
authors: Pal'tsyn
authors: V M
authors: VM
authors: Baranov
authors: A A
authors: AA
authors: Kubatiev
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology* / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology*; D004660:Encephalitis / Q000473:pathology; D020300:Intracranial Hemorrhages / Q000473:pathology*; D008297:Male; D009068:Movement / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000502:physiology; D014893:Weightlessness