title: The intriguing options of multispecific antibody formats for treatment of cancer.
abstract: The advent of various technologies for the generation of bi- and multispecific recombinant antibody-based molecules brought with it a multitude of formats for selecting target combinations. Some of the format options are outlined from a technical point of view. We focus on the achievements and prospects of the underlying technologies for generating bi- and multispecific antibodies to i) target immune effector cells and/or cytokines to tumors, ii) engage death receptors on tumor cells simultaneously, iii) improve antiangiogenic intervention by blocking complementary pathways of angiogenesis and iv) achieve more efficient targeting of human epidermal growth factor-related and other receptor tyrosine kinase-related pathways. Many of the outlined approaches, in addition to potential improvement of therapeutic efficacy in comparison to single agent intervention, also offer the potential to counteract therapy resistance.
authors: Roche Pharma Research and Early Development (pRED), Roche Diagnostics GmbH, Nonnenwald 2, D-82372 Penzberg, Germany. ulrich.weidle@roche.com
authors: Ulrich H
authors: UH
authors: Weidle
authors: Georg
authors: G
authors: Tiefenthaler
authors: Elisabeth H
authors: EH
authors: Weiss
authors: Guy
authors: G
authors: Georges
authors: Ulrich
authors: U
authors: Brinkmann
mesh_terms: D000818:Animals; D018033:Antibodies, Bispecific / Q000494:pharmacology / Q000627:therapeutic use*; D000920:Antibody-Dependent Cell Cytotoxicity; D000951:Antigens, Neoplasm / Q000276:immunology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018106:CD28 Antigens / Q000276:immunology; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000276:immunology; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D017434:Protein Structure, Tertiary; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology
chemical_list: D018033:Antibodies, Bispecific; D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D018106:CD28 Antigens