title: Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism.
abstract: Obesity is a serious medical problem worldwide and disruption of metabolic/energy homeostasis plays a pivotal role in this global epidemic. In obese people, fatty liver (steatosis) develops, which increases the risk for diabetes, cardiovascular disease, and even, liver cancer. Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that functions as a key metabolic/energy sensor and mediates homeostatic responses to nutrient availability. Accumulating evidence indicates that SIRT1 is a master regulator of the transcriptional networks that control hepatic lipid metabolism. During energy-deprived conditions, SIRT1 deacetylates and alters the expression and activities of key transcriptional regulators involved in hepatic lipogenesis, fatty acid β-oxidation, and cholesterol/bile acid metabolism. This review will discuss the latest advances in this field, focusing on beneficial roles of SIRT1 in hepatic lipid metabolism including its potential as a therapeutic target for treatment of steatosis and other obesity-related metabolic diseases.
authors: Department of Molecular and Integrative Physiology, University of Illinois at Urbana, Urbana, Illinois, USA. jongsook@illinois.edu
authors: Jongsook Kim
authors: JK
authors: Kemper
authors: Sung-E
authors: SE
authors: Choi
authors: Dong Hyun
authors: DH
authors: Kim
mesh_terms: D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D056564:Sirtuin 1 / Q000235:genetics / Q000378:metabolism*
chemical_list: C447939:SIRT1 protein, human; D056564:Sirtuin 1
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