title: The effects of poor quality sleep on brain function and risk taking in adolescence.
abstract: Insufficient sleep and poor quality sleep are pervasive during adolescence and relate to impairments in cognitive control and increased risk taking. However, the neurobiology underlying the association between sleep and adolescent behavior remains elusive. In the current study, we examine how poor sleep quality relates to cognitive control and reward related brain function during risk taking. Forty-six adolescents participated in a functional magnetic imaging (fMRI) scan during which they completed a cognitive control and risk taking task. Behaviorally, adolescents who reported poorer sleep also exhibited greater risk-taking. This association was paralleled by less recruitment of the dorsolateral prefrontal cortex (DLPFC) during cognitive control, greater insula activation during reward processing, and reduced functional coupling between the DLPFC and affective regions including the insula and ventral striatum during reward processing. Collectively, these results suggest that poor sleep may exaggerate the normative imbalance between affective and cognitive control systems, leading to greater risk-taking in adolescents.
authors: Department of Psychology, University of Illinois, Urbana-Champaign, USA. ehtelzer@illinois.edu
authors: Eva H
authors: EH
authors: Telzer
authors: Andrew J
authors: AJ
authors: Fuligni
authors: Matthew D
authors: MD
authors: Lieberman
authors: Adriana
authors: A
authors: Galván
mesh_terms: D000293:Adolescent; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003657:Decision Making / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012201:Reward; D012309:Risk-Taking; D012890:Sleep
references: Neuroimage. 2008 Jun;41(2):286-301
references: 18407525
references: Sleep. 2007 May;30(5):603-9
references: 17552375
references: Neuropsychologia. 2007 Mar 25;45(6):1270-9
references: 17118409
references: Behav Brain Funct. 2009 Feb 19;5:9
references: 19228430
references: Prev Med. 2011 Oct;53(4-5):271-3
references: 21843548
references: J Neurosci. 2006 Jun 21;26(25):6885-92
references: 16793895
references: Trends Neurosci. 2009 Jan;32(1):56-67
references: 18986715
references: J Neurosci. 2011 Mar 9;31(10):3712-8
references: 21389226
references: J Adolesc. 1989 Sep;12(3):265-78
references: 2687339
references: Mol Psychiatry. 2012 May;17(5):511-9
references: 21483437
references: Addict Behav. 2012 Apr;37(4):507-12
references: 22285119
references: Neuroimage. 1997 Feb;5(2):83-96
references: 9345540
references: Nat Rev Neurosci. 2012 Sep;13(9):636-50
references: 22903221
references: J Sleep Res. 2011 Sep;20(3):395-403
references: 20946437
references: Behav Sleep Med. 2005;3(3):113-33
references: 15984914
references: Brain Cogn. 2010 Feb;72(1):124-33
references: 19695759
references: J Neurosci. 2011 Mar 23;31(12):4466-74
references: 21430147
references: Pediatr Clin North Am. 2011 Jun;58(3):637-47
references: 21600346
references: J Exp Psychol Appl. 2000 Sep;6(3):236-49
references: 11014055
references: Front Hum Neurosci. 2009 Jan 16;2:19
references: 19242558
references: Trends Cogn Sci. 2009 Aug;13(8):334-40
references: 19643659
references: Dev Psychobiol. 2010 Apr;52(3):216-24
references: 20213754
references: Neuron. 2002 Jan 17;33(2):301-11
references: 11804576
references: Neuroimage. 2011 Sep 15;58(2):595-604
references: 21745579
references: Psychiatry Res. 1989 May;28(2):193-213
references: 2748771
references: Neuropsychopharmacology. 2002 Mar;26(3):376-86
references: 11850152
references: Neuroreport. 1999 Dec 16;10(18):3745-8
references: 10716202
references: Biol Psychol. 2012 Dec;91(3):334-41
references: 22960270
references: J Adolesc Health. 2009 Oct;45(4):326-34
references: 19766936
references: Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9
references: 15148381
references: Neuropsychol Rev. 2011 Mar;21(1):5-21
references: 21225346
references: J Adolesc Health. 2002 Dec;31(6 Suppl):175-84
references: 12470913
references: Cereb Cortex. 2010 Jul;20(7):1613-29
references: 19875675
references: Front Behav Neurosci. 2011 Oct 24;5:70
references: 22028686
references: Behav Res Methods. 2007 Aug;39(3):384-9
references: 17958149
references: J Adolesc. 2003 Aug;26(4):475-9
references: 12887935
references: Neuroimage. 1997 Oct;6(3):218-29
references: 9344826
references: Dev Sci. 2007 Mar;10(2):F8-F14
references: 17286837
references: Dev Sci. 2011 Mar;14(2):F1-10
references: 21499511
references: J Exp Psychol Appl. 2002 Jun;8(2):75-84
references: 12075692
references: J Cogn Neurosci. 2013 Mar;25(3):374-87
references: 23163412
references: Front Neurosci. 2012 Jun 04;6:80
references: 22675289
references: Neuroimage. 2002 Oct;17(2):825-41
references: 12377157
references: J Child Psychol Psychiatry. 2012 Jun;53(6):660-7
references: 22188424
references: Pharmacol Biochem Behav. 2009 Sep;93(3):258-62
references: 19041886
references: Neuroimage. 2003 Oct;20(2):1052-63
references: 14568475
references: J Neurosci. 2006 Jul 5;26(27):7156-62
references: 16822972
references: Pediatrics. 2009 Apr;123(4):e701-7
references: 19336360
references: J Child Psychol Psychiatry. 2008 Sep;49(9):915-23
references: 18564072
references: Curr Biol. 2007 Oct 23;17(20):R877-8
references: 17956744