title: Effector memory and late memory T cells accumulate in the blood of CMV-carrying individuals but not in their cerebrospinal fluid.
abstract: Cytomegalovirus (CMV)-carrying individuals have significantly higher levels of effector memory and late memory T lymphocytes in their blood than non-carriers. To date, it is well recognized that the central nervous system is subjected to active immunosurveillance, as evidenced by the presence of central memory T cells in cerebrospinal fluid (CSF) of healthy individuals. In order to investigate whether levels of effector memory and late memory T cells were also increased in the CSF of CMV-carrying individuals, we characterized CD4⁺ and CD8⁺ T-cell subsets in CSF and blood of both groups. Effector memory and late memory T cells were only rarely seen in CSF, which was similar in CMV carriers and non-carriers. In conclusion, there was no demonstrable difference in the numbers of CSF effector memory and late memory T cells between CMV seronegative and CMV seropositive individuals.
authors: Department of Medical Oncology, Erasmus University Medical Centre/Daniel Den Hoed Cancer Centre, Groene Hilledijk 301, 3075EA, Rotterdam, The Netherlands.
authors: Adriaan H C
authors: AH
authors: de Jongste
authors: Marieke T
authors: MT
authors: de Graaf
authors: Patricia D M
authors: PD
authors: van den Broek
authors: Jaco
authors: J
authors: Kraan
authors: Peter A E
authors: PA
authors: Sillevis Smitt
authors: Jan W
authors: JW
authors: Gratama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002490:Central Nervous System / Q000276:immunology / Q000821:virology*; D002555:Cerebrospinal Fluid / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D003587:Cytomegalovirus / Q000378:metabolism* / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000821:virology; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D017493:Leukocyte Common Antigens / Q000097:blood / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged
chemical_list: D017493:Leukocyte Common Antigens