title: Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model.
abstract: The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line "Tg(mpx:gfp)" to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
authors: Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan. yauhung@mail.tku.edu.tw
authors: Yau-Hung
authors: YH
authors: Chen
authors: Wei-Hua
authors: WH
authors: Wang
authors: Yun-Hsin
authors: YH
authors: Wang
authors: Zi-Yu
authors: ZY
authors: Lin
authors: Chi-Chung
authors: CC
authors: Wen
authors: Ching-Yuh
authors: CY
authors: Chern
mesh_terms: D058500:Animal Fins / Q000601:surgery; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000201:enzymology; D023421:Models, Animal; D020556:Neutrophil Infiltration / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects; D015027:Zebrafish / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D002599:Chalcone; D009195:Peroxidase
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