title: The effect of vitamin E-bonded polysulfone membrane dialyzer on a new oxidative lipid marker.
abstract: The use of vitamin E-bonded cellulose membrane dialyzers has been reported to cause a decrease in oxidative lipid marker levels (Nakai et al., Ther Apher Dial 14:505-540, 1; Nakai et al., J Jpn Soc Dial Ther 45:1-47, 2; Mashiba et al., Arterioscler Thromb Vasc Biol 21:1801-1808, 3). However, few studies have identified this effect with vitamin E-bonded polysulfone membranes, and no studies report the same effect on alpha (1) antitrypsin-LDL complex, a new oxidative lipid marker. This prompted us to examine the influence of use of VPS-HA vitamin E-bonded polysulfone high-flux membrane dialyzers on this new oxidative lipid marker. The subjects were 17 patients who had been dialyzed with VPS-HA for 12 months. The subjects' baseline characteristics were as follows. Their average age was 65.6 ± 13.1 years, comprising 8 males and 9 females; hemodialysis vintage was 83.8 ± 85.4 months. Eight had chronic glomerular nephropathy and five had diabetic nephropathy. The primary outcome was defined as alpha (1) antitrypsin-LDL complex level after 12 months, as a post-study using VPS-HA. Secondary outcomes included triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol levels. The data were analyzed pre-study and after 3, 6, 9 and 12 months for alpha (1) antitrypsin-LDL complex, and pre-study and post-study for the other indicators. Twelve months after switching to VPS-HA, alpha (1) antitrypsin-LDL complex, total cholesterol and LDL cholesterol had significantly decreased. Triglycerides and HDL cholesterol had not significantly changed. Hemodialysis therapy with VPS-HA was shown to decrease alpha (1) antitrypsin-LDL complex, an index of oxidative stress, and also to decrease some lipid markers.
authors: Department of Kidney Disease, Kawashima Hospital, Tokushima, Japan. ykitamur@kyotolan.hosp.go.jp
authors: Yuki
authors: Y
authors: Kitamura
authors: Kumi
authors: K
authors: Kamimura
authors: Noriko
authors: N
authors: Yoshioka
authors: Yoko
authors: Y
authors: Hosotani
authors: Kenji
authors: K
authors: Tsuchida
authors: Masahide
authors: M
authors: Koremoto
authors: Jun
authors: J
authors: Minakuchi
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D018384:Oxidative Stress; D006435:Renal Dialysis / Q000295:instrumentation*; D018709:Statistics, Nonparametric; D014810:Vitamin E / Q000494:pharmacology*; D000515:alpha 1-Antitrypsin / Q000097:blood
chemical_list: D015415:Biomarkers; D008055:Lipids; D008567:Membranes, Artificial; D000515:alpha 1-Antitrypsin; D014810:Vitamin E
references: J Nephrol. 2006 Jan-Feb;19(1):57-64
references: 16523427
references: Artif Organs. 2012 Oct;36(10):901-10
references: 22845774
references: Atherosclerosis. 2009 Jun;204(2):526-31
references: 19007930
references: J Am Soc Nephrol. 1997 Sep;8(9):1431-6
references: 9294835
references: Kidney Int. 2001 May;59(5):1943-50
references: 11318967
references: Ther Apher Dial. 2010 Dec;14(6):505-40
references: 21118359
references: Nephrol Dial Transplant. 2005 Dec;20(12):2775-82
references: 16221689
references: Arterioscler Thromb Vasc Biol. 2001 Nov;21(11):1801-8
references: 11701469
references: J Lipid Res. 1970 Nov;11(6):583-95
references: 4100998