title: Potentially functional polymorphism in IL-23 receptor and risk of acute myeloid leukemia in a Chinese population.
abstract: The interleukin-23 (IL-23) and its receptor (IL-23R) mediate the direct antitumor activities in human hematologic malignancies including pediatric acute leukemia. Two potentially functional genetic variants (IL-23R rs1884444 T>G and rs6682925 T>C) have been found to contribute to solid cancer susceptibility. In this study, we conducted a case-control study including 545 acute myeloid leukemia (AML) patients and 1,146 cancer-free controls in a Chinese population to assess the association between these two SNPs and the risk of AML. We found that IL-23R rs1884444 TG/GG and rs6682925 TC/CC variant genotypes were associated with significantly increased risk of AML [rs1884444: adjusted odds ratio (OR) = 1.28, 95% confidence interval (CI) = 1.01-1.62; rs6682925: adjusted OR = 1.30, 95%CI = 1.01-1.67], compared to their corresponding wild-type homozygotes, respectively. These findings indicated that genetic variants in IL-23R may contribute to AML risk in our Chinese population.
authors: Department of Hematology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
authors: Xifeng
authors: X
authors: Qian
authors: Songyu
authors: S
authors: Cao
authors: Guohua
authors: G
authors: Yang
authors: Yun
authors: Y
authors: Pan
authors: Chenyu
authors: C
authors: Yin
authors: Xiang
authors: X
authors: Chen
authors: Ying
authors: Y
authors: Zhu
authors: Yun
authors: Y
authors: Zhuang
authors: Yunfeng
authors: Y
authors: Shen
authors: Zhibin
authors: Z
authors: Hu
mesh_terms: D000328:Adult; D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin
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