title: Sugammadex rescue following prolonged rocuronium neuromuscular blockade with 'recurarisation' in a patient with severe renal failure.
abstract: We describe our experience of a 71-year-old patient with severe renal failure, who exhibited an unusually prolonged rocuronium-induced neuromuscular blockade (>4 h) and apparent recurarisation, following emergency rapid sequence induction (RSI). At the end of operation, 45 min post induction, train-of-four (TOF) testing had been 4/4 prior to wake up. No respiratory effort was seen 150 min postinduction, despite further neostigmine/glycopyrrolate and repeat TOF 4/4. The patient was resedated and transferred to the intensive care unit (ICU). At 180 min postinduction, fade was evident on TOF, suggestive of rocuronium reblockade. At 285 min, the patient was extubated safely following sugammadex administration and discharged uneventfully from the ICU. An important lesson to recognise is the potential for extremely prolonged neuromuscular blockade following rocuronium in patients with severe renal failure, particularly when using the higher doses (1.2 mg/kg) required for RSI, and that TOF in such cases may not be reliable in detecting residual blockade.
authors: Department of Anaesthesia and Intensive Care Medicine, Freeman Hospital, Newcastle upon Tyne, UK. Stevelobaz@doctors.org.uk
authors: Steven
authors: S
authors: Lobaz
authors: Mario
authors: M
authors: Sammut
authors: Anand
authors: A
authors: Damodaran
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000378:metabolism; D000368:Aged; D000732:Androstanols / Q000009:adverse effects* / Q000493:pharmacokinetics; D055191:Delayed Emergence from Anesthesia / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000378:metabolism; D000077123:Rocuronium; D000077122:Sugammadex; D014517:Ureteral Obstruction / Q000150:complications; D047408:gamma-Cyclodextrins / Q000627:therapeutic use*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium
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