title: [Non-alcoholic steatohepatitis and cirrhosis in young adult patients with hypothalamic-pituitary dysfunction].
abstract: BACKGROUND
  In rare cases, hypothalamic-pituitary dysfunction can be associated with an extraordinarily active non-alcoholic steatohepatitis (NASH) and subsequent liver cirrhosis.
  
  
  METHODS
  The two young adult patients described in this report presented with NASH together with advanced liver fibrosis and cirrhosis 5 and 19 years, respectively after resection of a craniopharyngeoma.
  
  
  CONCLUSIONS
  In young patients and children with active steatohepatitis, an association with hypothalamic-pituitary dysfunction should be excluded. Especially hypothalamic-pituitary-related NASH tends to develop rapidly into liver cirrhosis.
authors: Institut für Pathologie, Universität Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.
authors: D
authors: D
authors: Goltz
authors: K
authors: K
authors: Schötta
authors: H
authors: H
authors: Zhou
authors: H-P
authors: HP
authors: Fischer
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D065626:Non-alcoholic Fatty Liver Disease; D010911:Pituitary Neoplasms / Q000601:surgery; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011183:Postoperative Complications / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult
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