title: Spinal meningeal oligodendrogliomatosis in two boxer dogs.
abstract: Two Boxer dogs developed progressive ataxia in association with a neoplastic infiltration of the spinal leptomeninges. In the first dog, the leptomeningeal neoplasm encompassed the entire cord and the ventral aspect of the brainstem and extended bilaterally into the piriform lobes. In the second, the neoplasm surrounded the C1-C3 segments of the spinal cord and the brainstem without involvement of the brain or spinal cord parenchyma. In both dogs, the neoplastic cells had variably distinct cell borders, clear to eosinophilic cytoplasm, and a round to ovoid hyperchromatic nucleus. Neoplastic cells were immunopositive for Olig2 and doublecortin in both dogs and for vimentin in one dog but were immunonegative for glial fibrillary acidic protein, S-100, CD34, E-cadherin, cytokeratin, CD3, and CD20. The morphological and immunohistochemical features of the neoplastic cells were consistent with an oligodendrocyte lineage. This hitherto poorly recognized neoplasm in dogs is analogous to human leptomeningeal oligodendrogliomatosis.
authors: Department of Veterinary Population Medicine, Minnesota Veterinary Diagnostic Laboratory, University of Minnesota, 1333 Gortner Ave, St. Paul, MN 55108, USA. rckovi@umn.edu
authors: R C
authors: RC
authors: Kovi
authors: A
authors: A
authors: Wünschmann
authors: A G
authors: AG
authors: Armién
authors: K
authors: K
authors: Hall
authors: T
authors: T
authors: Carlson
authors: J
authors: J
authors: Shivers
authors: M J
authors: MJ
authors: Oglesbee
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D000089622:Doublecortin Domain Proteins; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology / Q000662:veterinary*; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D009837:Oligodendroglioma / Q000473:pathology / Q000662:veterinary*
chemical_list: D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides
keywords: dog diseases; immunohistochemistry; leptomeninges; neoplasms; oligodendrogliomatosis; spinal cord