title: Diagnostic performance of percutaneous lung biopsy using automated biopsy needles under CT-fluoroscopic guidance for ground-glass opacity lesions.
abstract: OBJECTIVE
  The goal of our study was to evaluate the diagnostic performance of percutaneous lung biopsy under CT-fluoroscopic guidance for ground-glass opacity (GGO) lesions.
  
  
  METHODS
  85 percutaneous needle lung biopsies were performed in 73 patients. Specimens were obtained by core biopsy utilising an automated cutting needle and were evaluated histologically. Final diagnosis was confirmed by independent surgical pathology, independent culture results or clinical follow-up.
  
  
  RESULTS
  Rates of adequate specimens obtained and of precise diagnosis by needle biopsy were 92.9% (79/85) and 90.6% (77/85) of evaluated lung lesions, respectively. Precise diagnosis was achieved in 87.1% (27/31) of lesions ≤10 mm in diameter, 90.0% (36/40) of lesions >10 mm to ≤20 mm and 100.0% (14/14) of lesions >20 mm. Precision in diagnosing GGO lesions according to the GGO component was 73.9% (17/23) for pure GGO lesions and 96.8% (60/62) for part-solid GGO lesions. Obtaining a precise diagnosis did not differ significantly according to the lesion size (p=0.3840), but differences were significant according to the GGO component (p=0.0047). Malignancy was accurately diagnosed in 35 of 36 malignant lesions for which surgery was later performed. The specific cell type determined from specimens obtained by needle biopsy was exactly the same as the final histological diagnosis obtained after surgery in 20 lesions.
  
  
  CONCLUSIONS
  Tissue-core lung biopsy under CT-fluoroscopic guidance for a GGO lesion provides a high degree of diagnostic accuracy but is less reliable for determining the specific cell type.
  
  
  CONCLUSIONS
  Percutaneous lung biopsy under CT-fluoroscopic guidance for GGO is useful in differentiating malignancy.
authors: Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. yamagami@koto.kpu-m.ac.jp
authors: T
authors: T
authors: Yamagami
authors: R
authors: R
authors: Yoshimatsu
authors: H
authors: H
authors: Miura
authors: K
authors: K
authors: Yamada
authors: A
authors: A
authors: Takahata
authors: T
authors: T
authors: Matsumoto
authors: T
authors: T
authors: Hasebe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000592:standards; D005260:Female; D005471:Fluoroscopy / Q000592:standards; D006801:Humans; D061705:Image-Guided Biopsy / Q000592:standards; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015641:Radiography, Interventional / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods
references: Radiology. 1980 Oct;137(1 Pt 1):31-5
references: 7422857
references: Radiology. 1994 Dec;193(3):789-93
references: 7972826
references: J Thorac Oncol. 2012 Jan;7(1):143-50
references: 22124475
references: Br J Radiol. 2008 Feb;81(962):107-12
references: 18070823
references: Ann Thorac Surg. 2000 Mar;69(3):893-7
references: 10750779
references: Radiology. 1988 May;167(2):457-61
references: 3357956
references: Br J Radiol. 2012 Mar;85(1011):208-13
references: 21828150
references: AJR Am J Roentgenol. 2008 Jan;190(1):234-9
references: 18094317
references: Radiology. 1996 Mar;198(3):715-20
references: 8628859
references: Acta Radiol. 2009 Dec;50(10):1126-33
references: 19922309
references: AJR Am J Roentgenol. 1997 Sep;169(3):661-6
references: 9275873
references: J Thorac Oncol. 2011 Apr;6(4):751-6
references: 21325976
references: Radiology. 1996 Sep;200(3):851-6
references: 8756943
references: Radiology. 1999 May;211(2):309-15
references: 10228508
references: Lancet. 1998 Apr 25;351(9111):1242-5
references: 9643744
references: Radiology. 1999 Jul;212(1):165-8
references: 10405737
references: Radiology. 1996 Dec;201(3):798-802
references: 8939234
references: Cardiovasc Intervent Radiol. 2000 Jul-Aug;23(4):266-72
references: 10960539
references: Chest. 2002 Apr;121(4):1159-64
references: 11948047
references: AJR Am J Roentgenol. 2000 Jul;175(1):239-43
references: 10882279
references: Chest. 2003 Jul;124(1):147-54
references: 12853517
references: AJR Am J Roentgenol. 1995 Jul;165(1):53-5
references: 7785631
references: Ann Thorac Surg. 2006 Feb;81(2):413-9
references: 16427823
references: AJR Am J Roentgenol. 1985 Apr;144(4):787-92
references: 3872039
references: Radiology. 1999 Jan;210(1):59-64
references: 9885587
references: J Cardiovasc Surg (Torino). 1997 Oct;38(5):539-42
references: 9358817
references: Ann Thorac Surg. 2002 Nov;74(5):1635-9
references: 12440622
references: Radiology. 1994 Jan;190(1):243-6
references: 8259413
references: Chest. 2002 May;121(5):1464-7
references: 12006429
references: Cancer. 1995 Jun 15;75(12):2844-52
references: 7773933
references: AJR Am J Roentgenol. 1999 Apr;172(4):1049-53
references: 10587145
references: Eur J Radiol. 2011 Aug;79(2):e85-9
references: 21515009
references: Korean J Radiol. 2006 Apr-Jun;7(2):80-6
references: 16799268
references: J Thorac Imaging. 2012 Jul;27(4):240-8
references: 22847591
references: AJR Am J Roentgenol. 2003 Mar;180(3):811-5
references: 12591702
references: Lancet. 1999 Jul 10;354(9173):99-105
references: 10408484
references: Radiology. 1996 Feb;198(2):371-5
references: 8596834
references: J Thorac Imaging. 2011 May;26(2):106-18
references: 21508733
references: Radiology. 1998 Jun;207(3):759-65
references: 9609901
references: Clin Radiol. 1996 Jul;51(7):503-6
references: 8689827
references: Radiology. 1988 Dec;169(3):593-601
references: 3055026
references: AJR Am J Roentgenol. 1997 Aug;169(2):355-67
references: 9242736
references: AJR Am J Roentgenol. 2009 Mar;192(3):629-34
references: 19234257
references: Radiology. 1996 Aug;200(2):327-31
references: 8685321
references: Proc Am Thorac Soc. 2011 Sep;8(5):381-5
references: 21926387
references: Radiology. 1991 Dec;181(3):778
references: 1947096
references: Radiology. 1996 Sep;200(3):695-7
references: 8756917
references: Ann Thorac Surg. 2012 Jul;94(1):212-5
references: 22560966
references: AJR Am J Roentgenol. 1998 Feb;170(2):329-31
references: 9456939
references: J Vasc Interv Radiol. 2001 Feb;12(2):215-9
references: 11265886