title: Cyclin D1 polymorphism in non-small cell lung cancer in a Portuguese population.
abstract: Cyclin D1 (CCND1) is a key regulatory protein of the cell cycle. The purpose of our study was to assess the role of CCND1 genetic variants influencing the genetic susceptibility of non-small cell lung cancer (NSCLC). We conducted a study of 1234 individuals, including 892 controls and 342 cases. Individuals carrying two G-alleles have a 2-fold increased risk for the development of NSCLC and the waiting time for onset of NSCLC in these patients was 2 years earlier in comparison with other individuals. Our results may be important in contributing to the knowledge of the mechanisms involved in lung carcinogenesis.
authors: Molecular Oncology GRP CI, Medical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal. raquelcatarino@yahoo.com
authors: R
authors: R
authors: Catarino
authors: A
authors: A
authors: Coelho
authors: A
authors: A
authors: Nogueira
authors: A
authors: A
authors: Araújo
authors: M
authors: M
authors: Gomes
authors: C
authors: C
authors: Lopes
authors: R
authors: R
authors: Medeiros
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D016022:Case-Control Studies; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011174:Portugal
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1