title: Assisted reproductive technologies and children's neurodevelopmental outcomes.
abstract: Initial reports suggested that children conceived with assisted reproductive technologies (ART) may be at increased risk for a spectrum of developmental disabilities. Evolving evidence suggests that some of the early risks may have been overstated when not taking plurality of birth or gestational age at delivery into consideration, as both are independent risk factors for neurodevelopmental disabilities arising from alterations in structure and function or limitations in activities. Continued research is needed to overcome lingering data gaps in light of the equivocal literature for many neurodevelopmental disabilities relative to ART, increasing utilization of services, and changes in the clinical management of infecund couples such as the adoption of natural cycles or in vitro maturation treatment options. Population-based cohorts with longitudinal assessment of the multifaceted nature of neurodevelopment across critical and sensitive windows is paramount for the development of empirically based guidance for clinical and population health.
authors: Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA. hedigerm@exchange.nih.gov
authors: Mary L
authors: ML
authors: Hediger
authors: Erin M
authors: EM
authors: Bell
authors: Charlotte M
authors: CM
authors: Druschel
authors: Germaine M
authors: GM
authors: Buck Louis
mesh_terms: D015984:Causality; D002658:Developmental Disabilities / Q000453:epidemiology*; D019317:Evidence-Based Medicine; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D009422:Nervous System Diseases / Q000453:epidemiology*; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D012307:Risk Factors
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