title: [Genetic markers of individual susceptibility and oxidative stress in subjects exposed to low dose of benzene. Preliminary data].
abstract: In the present study we used AOPPs and AGE as early markers of oxidative stress in refinery oil workers. In addition we evaluated whether a genetically determined reduction in the ability to detoxify electrophilic compounds, such as that expected among individuals with glutathione S-transferase (GST) null genotypes might influence the levels of AOPPs thus increasing toxicity. The study was performed on 25 oil refinery workers and in 18 age-matched control subjects. We found a statistically significant increase of AOPPs in exposed workers with respect to controls while AGE levels were not different. Finally serum level of AOPPs and AGE were not correlated with the different GTS genotypes.
authors: Dipartimento di Medicina Sociale del Territorio, Università degli Studi di Messina, AOU Policlinico G. Martino, Via C. Valeria, 98125 Messina, Italy. gspatari@unime.it
authors: G
authors: G
authors: Spatari
authors: C
authors: C
authors: Abbate
authors: C
authors: C
authors: Giorgianni
authors: M
authors: M
authors: Carrieri
authors: D
authors: D
authors: Sapienza
authors: S
authors: S
authors: Saitta
authors: M
authors: M
authors: Barbaro
mesh_terms: D001554:Benzene / Q000008:administration & dosage / Q000009:adverse effects*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016273:Occupational Exposure; D018384:Oxidative Stress / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D001554:Benzene