title: A new synthetic protocol for coumarin amino acid.
abstract: The hydrochloride of the racemic amino acid (2-(7-hydroxycoumarin-4-yl)ethyl)glycine, which can serve as a fluorescent probe in proteins, and two halogen derivatives of it, were synthesized by using a new synthetic protocol in five steps. It is less costly and relatively easy to prepare this kind of fluorescent amino acid with the new synthetic method. Furthermore, it can be applied to synthesize other derivatives of the coumarin amino acid with some specific properties.
authors: Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China ; Graduate University of the Chinese Academy of Sciences, Beijing 100864, China.
authors: Xinyi
authors: X
authors: Xu
authors: Xiaosong
authors: X
authors: Hu
authors: Jiangyun
authors: J
authors: Wang
keywords: Pechmann condensation; coumarin; fluorescent probe; halogen derivatives; non-natural amino acid
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