title: Inhaled corticosteroid-induced hair depigmentation in a child.
abstract: An Afro-Caribbean girl showed localized hair depigmentation during treatment with inhaled fluticasone propionate. Although skin depigmentation is common after topical use of corticosteroids, hair depigmentation has never been reported with inhaled corticosteroids. The mechanisms underlying corticosteroid-induced skin depigmentation are not completely understood, but accepted hypotheses suggest a direct cytotoxic effect, changes in ground substance, vasoconstriction, mechanical effects of edema, or a dysregulation of melanogenesis.
authors: Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine de Toulouse, Toulouse, France.
authors: Charlotte
authors: C
authors: Bezzina
authors: Emmanuelle
authors: E
authors: Bondon-Guitton
authors: Jean-Louis
authors: JL
authors: Montastruc
mesh_terms: D000730:Androstadienes / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001249:Asthma / Q000150:complications / Q000188:drug therapy; D002675:Child, Preschool; D003231:Conjunctivitis / Q000150:complications / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D005260:Female; D000068298:Fluticasone; D006200:Hair Color / Q000187:drug effects*; D006201:Hair Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D039981:Pyroglyphidae; D012130:Respiratory Hypersensitivity / Q000150:complications / Q000188:drug therapy; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000188:drug therapy; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000730:Androstadienes; D018926:Anti-Allergic Agents; D000068298:Fluticasone