title: Voriconazole suppresses the growth of Leishmania species in vitro.
abstract: The digenetic protozoan Leishmania is dependent on ergosterol synthesis for growth and viability. We compared the in vitro activity of ergosterol synthesis inhibitor voriconazole with fluconazole and ketoconazole against cutaneous and visceral Leishmania species. We found the IC50 of voriconazole was comparable to ketoconazole and both were superior to fluconazole. Both ketoconazole and voriconazole were active against insect and mammalian stage parasites. This is the first report of the in vitro activity of voriconazole against leishmanial species.
authors: Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA.
authors: Manjusha M
authors: MM
authors: Kulkarni
authors: Niveditha
authors: N
authors: Reddy
authors: Tulasi
authors: T
authors: Gude
authors: Bradford S
authors: BS
authors: McGwire
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007654:Ketoconazole / Q000494:pharmacology; D007891:Leishmania / Q000145:classification / Q000187:drug effects* / Q000254:growth & development*; D021261:Parasitic Sensitivity Tests; D011743:Pyrimidines / Q000494:pharmacology*; D013045:Species Specificity; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000981:Antiprotozoal Agents; D011743:Pyrimidines; D014230:Triazoles; D015725:Fluconazole; D065819:Voriconazole; D007654:Ketoconazole
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