title: [Effect of intragastric creatine glycine ethylic ether fumarate administration in a rat model of occlusive ischemia].
abstract: The aim of the study was to investigate neuroprotective effect of creatine glycine ethylic ether fumarate (creamide). The methods involved intragastric administration of creamide in doses of 30 and 50 mg/kg twice a day for 10 days. Focal 30 minutes cerebral ischemia model by endovascular suture occlusion of the middle cerebral artery in a rat with subsequent reperfusion period for 48 hours was produced. Assessment of creamide stability in gastric juice was performed. Ischemic lesion volume accompanying focal ischemia was visualized and determined. Similar infarction patterns had been found with histological methods. Garcia scale was used for clinical study of neurological deficit in rats. Our data suggest a significant neuroprotective effect of creamide in dosage 50 mg/kg administered twice a day which decreased brain lesion volume produced by ischemic and reperfusion injury.
authors: N V
authors: NV
authors: Kratirova
authors: O S
authors: OS
authors: Veselkina
authors: M E
authors: ME
authors: Kolpakova
authors: S G
authors: SG
authors: Chefu
authors: D E
authors: DE
authors: Korzhevskiĭ
authors: A S
authors: AS
authors: Daĭneko
authors: M S
authors: MS
authors: Prosvirina
authors: A V
authors: AV
authors: Piskun
authors: T D
authors: TD
authors: Vlasov
mesh_terms: D000818:Animals; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000503:physiopathology; D004195:Disease Models, Animal; D005650:Fumarates / Q000008:administration & dosage* / Q000138:chemical synthesis; D008297:Male; D020768:Middle Cerebral Artery / Q000601:surgery; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000138:chemical synthesis; D051381:Rats; D015427:Reperfusion Injury / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D005650:Fumarates; D018696:Neuroprotective Agents; C579481:creatine glycine ethylic ether fumarate