title: Expression pattern implicates a potential role for luman recruitment factor in the process of implantation in uteri and development of preimplantation embryos in mice.
abstract: Luman/CREB3 recruitment factor (LRF or CREBRF) was identified as a regulator of Luman (or CREB3) that is involved in the unfolded protein response during endoplasmic reticulum stress. Luman is implicated in a multitude of functions ranging from viral infection and immunity to cancer. The biological function of LRF, however, is unknown. In this paper, we report that uteri of pregnant mice and embryos displayed enhanced LRF expression at all stages, and the expressed LRF was found to be localized specifically at implantation sites. On the other hand, uteri of mice induced for delayed implantation or pseudopregnant mice showed low levels of LRF expression, suggesting that LRF mediates uterine receptivity during implantation. Further, expression of LRF was found to be modulated by steroid hormones such as progesterone and estradiol. This study thereby identifies a potential role for LRF in the process of implantation in uteri and development of preimplantation embryos in mice.
authors: Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, PR China.
authors: Yanzhou
authors: Y
authors: Yang
authors: Yaping
authors: Y
authors: Jin
authors: Amanda C
authors: AC
authors: Martyn
authors: Pengfei
authors: P
authors: Lin
authors: Yujie
authors: Y
authors: Song
authors: Fenglei
authors: F
authors: Chen
authors: Linyong
authors: L
authors: Hu
authors: Chenchen
authors: C
authors: Cui
authors: Xiao
authors: X
authors: Li
authors: Qian
authors: Q
authors: Li
authors: Ray
authors: R
authors: Lu
authors: Aihua
authors: A
authors: Wang
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D003656:Decidua / Q000378:metabolism; D010064:Embryo Implantation / Q000502:physiology*; D004958:Estradiol / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D015398:Signal Transduction; D013256:Steroids / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism*; D014599:Uterus / Q000502:physiology*
chemical_list: C116472:Creb3 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D013256:Steroids; D014157:Transcription Factors; C117093:Zbtb7a protein, mouse; D011374:Progesterone; D004958:Estradiol
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