title: Polyomavirus-associated nephritis in 2 horses.
abstract: Polyomaviruses produce latent and asymptomatic infections in many species, but productive and lytic infections are rare. In immunocompromised humans, polyomaviruses can cause tubulointerstitial nephritis, demyelination, or meningoencephalitis in the central nervous system and interstitial pneumonia. This report describes 2 Standardbred horses with tubular necrosis and tubulointerstitial nephritis associated with productive equine polyomavirus infection that resembles BK polyomavirus nephropathy in immunocompromised humans.
authors: North Carolina State University, College of Veterinary Medicine, Department of Population Health and Pathobiology, 1060 William Moore Rd, Raleigh, NC 27607, USA. keith_linder@ncsu.edu
authors: S H
authors: SH
authors: Jennings
authors: A G
authors: AG
authors: Wise
authors: V
authors: V
authors: Nickeleit
authors: R K
authors: RK
authors: Maes
authors: R E
authors: RE
authors: Cianciolo
authors: F
authors: F
authors: Del Piero
authors: J M
authors: JM
authors: Law
authors: Y
authors: Y
authors: Kim
authors: A C
authors: AC
authors: McCalla
authors: B A
authors: BA
authors: Breuhaus
authors: M C
authors: MC
authors: Roberts
authors: K E
authors: KE
authors: Linder
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D036022:Capsid Proteins / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D006734:Horse Diseases / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D006736:Horses; D016867:Immunocompromised Host / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood; D007150:Immunohistochemistry / Q000662:veterinary; D007673:Kidney Cortex Necrosis / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D008297:Male; D009395:Nephritis, Interstitial / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D011120:Polyomavirus / Q000235:genetics*; D027601:Polyomavirus Infections / Q000473:pathology / Q000662:veterinary*
chemical_list: D036022:Capsid Proteins; D017931:DNA Primers; D007074:Immunoglobulin G; C062481:VP1 protein, polyomavirus
keywords: horse; kidney; myocarditis; nephritis; polyomavirus