title: Atopic dermatitis-like presentation of graft-versus-host disease: a novel form of chronic cutaneous graft-versus-host disease.
abstract: BACKGROUND
  Graft-versus-host disease (GVHD) is a systemic disease, and skin is often one of the target organs. An atopic dermatitis (AD)-like presentation has never to our knowledge been reported.
  
  
  OBJECTIVE
  We sought to describe an AD-like presentation of cutaneous GVHD.
  
  
  METHODS
  Data on 11 patients with an AD-like presentation of GVHD were collected. The clinical and laboratory findings were retrospectively studied.
  
  
  RESULTS
  All 11 patients developed skin lesions after hematopoietic stem-cell transplantation. The skin lesions occurred between 2 to 12 months after transplantation. Eight patients received their transplant from a first-degree family member; 3 received their transplant from an unrelated donor. The skin lesions were pruritic and suggestive of AD, whereas the histology showed features of AD and GVHD. The lesions responded to topical and systemic anti-inflammatory and immunosuppressive therapy and phototherapy.
  
  
  CONCLUSIONS
  The number of patients is small and the study is retrospective.
  
  
  CONCLUSIONS
  AD-like GVHD might represent a novel form of chronic cutaneous GVHD and responds well to treatment.
authors: Department of Dermatology, Peking University People's Hospital, Beijing, China.
authors: Jin
authors: J
authors: Wei
authors: Yu
authors: Y
authors: Zhang
authors: Hongjun
authors: H
authors: Xu
authors: Jiang
authors: J
authors: Jin
authors: Jianzhong
authors: J
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine