title: Immunohistochemical expression of Skp2 protein in oral nevi and melanoma.
abstract: OBJECTIVE
  The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oral nevi and 11 primary oral melanomas.
  
  
  METHODS
  Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was assessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide.
  
  
  RESULTS
  Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of this protein.
  
  
  CONCLUSIONS
  These results indicate that Skp2 protein may play a role in the development and progression of oral melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral benign and malignant melanocytic lesions.
authors: Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. augustodelima33@hotmail.com
authors: Bruno-Augusto
authors: BA
authors: Benevenuto-de-Andrade
authors: Jorge-Esquiche
authors: JE
authors: León
authors: Román
authors: R
authors: Carlos
authors: Wilson
authors: W
authors: Delgado-Azañero
authors: Adalberto
authors: A
authors: Mosqueda-Taylor
authors: Oslei
authors: O
authors: Paes-de-Almeida
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000378:metabolism*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000378:metabolism*; D009506:Nevus / Q000737:chemistry / Q000378:metabolism*; D044786:S-Phase Kinase-Associated Proteins / Q000032:analysis / Q000096:biosynthesis*; D055815:Young Adult
chemical_list: D044786:S-Phase Kinase-Associated Proteins
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