title: Activity in inferior parietal and medial prefrontal cortex signals the accumulation of evidence in a probability learning task.
abstract: In an uncertain environment, probabilities are key to predicting future events and making adaptive choices. However, little is known about how humans learn such probabilities and where and how they are encoded in the brain, especially when they concern more than two outcomes. During functional magnetic resonance imaging (fMRI), young adults learned the probabilities of uncertain stimuli through repetitive sampling. Stimuli represented payoffs and participants had to predict their occurrence to maximize their earnings. Choices indicated loss and risk aversion but unbiased estimation of probabilities. BOLD response in medial prefrontal cortex and angular gyri increased linearly with the probability of the currently observed stimulus, untainted by its value. Connectivity analyses during rest and task revealed that these regions belonged to the default mode network. The activation of past outcomes in memory is evoked as a possible mechanism to explain the engagement of the default mode network in probability learning. A BOLD response relating to value was detected only at decision time, mainly in striatum. It is concluded that activity in inferior parietal and medial prefrontal cortex reflects the amount of evidence accumulated in favor of competing and uncertain outcomes.
authors: Computation and Neural Systems, California Institute of Technology, Pasadena, CA, USA. dacremon@hss.caltech.edu
authors: Mathieu
authors: M
authors: d'Acremont
authors: Eleonora
authors: E
authors: Fornari
authors: Peter
authors: P
authors: Bossaerts
mesh_terms: D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D007858:Learning; D008279:Magnetic Resonance Imaging; D010296:Parietal Lobe / Q000502:physiology*; D011336:Probability
references: Nat Rev Neurosci. 2008 Aug;9(8):613-25
references: 18641668
references: Nature. 2008 Nov 13;456(7219):245-9
references: 19005555
references: Neuropsychology. 1999 Oct;13(4):564-74
references: 10527065
references: Neuroimage. 2003 Aug;19(4):1612-26
references: 12948716
references: J Neurosci. 2005 Dec 7;25(49):11340-8
references: 16339029
references: J Neurosci. 2009 Sep 30;29(39):12315-20
references: 19793990
references: Cogn Affect Behav Neurosci. 2011 Sep;11(3):277-91
references: 21638193
references: J Neurosci. 2010 Jun 23;30(25):8445-56
references: 20573892
references: Eur J Neurosci. 2012 Apr;35(7):987-90
references: 22487029
references: Nat Neurosci. 2005 Nov;8(11):1603-10
references: 16234807
references: Neuroscientist. 2012 Jun;18(3):251-70
references: 21677128
references: Neuron. 2004 May 13;42(3):509-17
references: 15134646
references: Nat Rev Neurosci. 2008 Jun;9(6):467-79
references: 18464792
references: J Neurosci. 2009 Jan 28;29(4):1244-54
references: 19176832
references: Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10237-9
references: 12149485
references: Trends Cogn Sci. 2007 Jul;11(7):280-9
references: 17548232
references: Neuroimage. 2012 Jul 16;61(4):966-77
references: 22446489
references: J Exp Psychol. 1965 Mar;69:312-6
references: 14271338
references: Psychol Rev. 1993 Apr;100(2):183-203
references: 8483981
references: PLoS Comput Biol. 2011 Jan 20;7(1):e1001048
references: 21283774
references: Neuron. 2009 Jun 11;62(5):733-43
references: 19524531
references: J Neurophysiol. 2001 Oct;86(4):1916-36
references: 11600651
references: Nat Neurosci. 2010 Oct;13(10):1292-8
references: 20835253
references: Nat Rev Neurosci. 2010 Feb;11(2):127-38
references: 20068583
references: Neuron. 2008 Dec 26;60(6):1142-52
references: 19109917
references: Nat Neurosci. 2007 Dec;10(12):1625-33
references: 17982449
references: Am J Psychol. 1957 Jun;70(2):174-85
references: 13424757
references: Cogn Psychol. 1999 Feb;38(1):129-66
references: 10090801
references: Trends Cogn Sci. 2005 Sep;9(9):445-53
references: 16054861
references: Nature. 2007 Jun 28;447(7148):1075-80
references: 17546027
references: J Neurosci. 2008 Nov 19;28(47):12539-45
references: 19020046
references: J Neurosci. 2005 Nov 9;25(45):10420-36
references: 16280581
references: Brain. 1996 Dec;119 ( Pt 6):2073-83
references: 9010011
references: J Neurosci. 2005 Mar 30;25(13):3304-11
references: 15800185
references: Neuron. 2010 May 27;66(4):585-95
references: 20510862
references: Psychol Rev. 2004 Apr;111(2):333-67
references: 15065913
references: AMA Arch Neurol Psychiatry. 1958 May;79(5):475-97
references: 13519951
references: Nat Neurosci. 2011 Aug 26;14(9):1105-7
references: 21878926
references: Cogn Affect Behav Neurosci. 2008 Dec;8(4):363-74
references: 19033235
references: Trends Cogn Sci. 2009 Dec;13(12):517-23
references: 19836292
references: J Neurosci. 2009 Feb 18;29(7):2231-7
references: 19228976
references: J Neurophysiol. 2007 Feb;97(2):1621-32
references: 17122317
references: Neuron. 2009 Nov 12;64(3):431-9
references: 19914190
references: Curr Opin Neurobiol. 2008 Apr;18(2):185-96
references: 18708140
references: Neural Comput. 2008 Apr;20(4):873-922
references: 18085991
references: Cogn Affect Behav Neurosci. 2013 Mar;13(1):46-59
references: 23090717
references: J Exp Psychol. 1958 Jul;56(1):96
references: 13575703
references: Cogn Affect Behav Neurosci. 2007 Dec;7(4):367-79
references: 18189010
references: Brain Struct Funct. 2010 Jun;214(5-6):645-53
references: 20512378
references: Psychophysiology. 1977 Sep;14(5):456-67
references: 905483
references: Neural Netw. 2005 Apr;18(3):225-30
references: 15896570
references: Neuroimage. 2008 Feb 15;39(4):2047-57
references: 18060809
references: Nat Neurosci. 2001 Oct;4(10):1043-8
references: 11559855
references: Ann N Y Acad Sci. 2008 Mar;1124:1-38
references: 18400922
references: Neuron. 2001 Feb;29(2):537-45
references: 11239442
references: J Neurosci. 2006 Sep 13;26(37):9530-7
references: 16971537
references: Learn Mem. 1994 Jul-Aug;1(2):106-20
references: 10467589
references: Neuroimage. 2007 Nov 15;38(3):557-63
references: 17889562
references: Hippocampus. 2007;17(6):420-8
references: 17455334
references: Neuropsychologia. 2009 Sep;47(11):2222-38
references: 19041331
references: J Neurosci. 2007 Dec 26;27(52):14365-74
references: 18160644
references: Cereb Cortex. 2007 Nov;17(11):2669-74
references: 17259643
references: Neuroimage. 2003 Aug;19(4):1439-48
references: 12948701