title: Stanniocalcin1 (STC1) Inhibits Cell Proliferation and Invasion of Cervical Cancer Cells.
abstract: STC1 is a glycoprotein hormone involved in calcium/phosphate (Pi) homeostasis. There is mounting evidence that STC1 is tightly associated with the development of cancer. But the function of STC1 in cancer is not fully understood. Here, we found that STC1 is down-regulated in Clinical tissues of cervical cancer compared to the adjacent normal cervical tissues (15 cases). Subsequently, the expression of STC1 was knocked down by RNA interference in cervical cancer CaSki cells and the low expression promoted cell growth, migration and invasion. We also found that STC1 overexpression inhibited cell proliferation and invasion of cervical cancer cells. Moreover, STC1 overexpression sensitized CaSki cells to drugs. Further, we showed that NF-κB p65 protein directly bound to STC1 promoter and activated the expression of STC1 in cervical cancer cells. Thus, these results provided evidence that STC1 inhibited cell proliferation and invasion through NF-κB p65 activation in cervical cancer.
authors: Cancer Research Institute, Xiangya Medical School, Central South University, Changsha, China ; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, China ; Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, China ; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.
authors: Fengjie
authors: F
authors: Guo
authors: Yalin
authors: Y
authors: Li
authors: Jiajia
authors: J
authors: Wang
authors: Yandong
authors: Y
authors: Li
authors: Yuehui
authors: Y
authors: Li
authors: Guancheng
authors: G
authors: Li
mesh_terms: D000368:Aged; D000818:Animals; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D009367:Neoplasm Staging; D011401:Promoter Regions, Genetic; D014183:Transplantation, Heterologous; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology; D019892:eIF-2 Kinase / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D016328:NF-kappa B; C051795:teleocalcin; D019892:eIF-2 Kinase
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