title: Nrf2 to pre-condition the brain against injury caused by products of hemolysis after ICH.
abstract: Brain damage caused by intracerebral hemorrhage (ICH) is mediated in part by the toxicity of extravascular blood deposited in brain parenchyma during the hematoma formation. In this paper we discuss the therapeutic benefits and potential mechanisms associated with the activation of transcription factor Nrf2 regarding its role in defending brain tissue against toxicity of blood, a component of secondary injury. We emphasize the pleiotropic capacity of Nrf2 as it recruits multiple pathways aiming at reducing deleterious effects of blood lysis products.
authors: University of Texas Medical School - Houston; Department of Neurology, Stroke Program.
authors: Xiurong
authors: X
authors: Zhao
authors: Jaroslaw
authors: J
authors: Aronowski
mesh_terms: D002543:Cerebral Hemorrhage / Q000188:drug therapy*; D006461:Hemolysis; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D018384:Oxidative Stress
chemical_list: D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human
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