title: Primary localized cutaneous nodular amyloidosis successfully treated with cyclophosphamide.
abstract: Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare subtype of localized cutaneous amyloidosis and can be associated with various connective tissue disorders. It can be difficult to treat and past therapies include surgical excision, dermabrasion, electrodessication and curettage, cryotherapy and laser therapy. We present a case of a middle-aged woman with PLCNA associated with CREST (calcinosis, Raynaud phenomenon, oesophageal motility disorders, sclerodactyly and telangiectasia) syndrome and Sjögren's syndrome responding to cyclophosphamide with no new amyloid deposits and resolution of skin ulceration after many years of resistance to drug therapy. It is important to monitor these patients for progression into systemic amyloidosis.
authors: Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia. philipleitong@gmail.com
authors: Philip L
authors: PL
authors: Tong
authors: William A
authors: WA
authors: Walker
authors: Ross J
authors: RJ
authors: Glancy
authors: Julian P
authors: JP
authors: Cooney
authors: Kurt
authors: K
authors: Gebauer
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide