title: Spectroscopic investigation on the inclusion complex formation between amisulpride and γ-cyclodextrin.
abstract: The purpose of this research was to investigate inclusion complex formation between poorly soluble drug amisulpride (AMI) and γ-cyclodextrin (γ-CD). The solubility of AMI was enhanced by formation of inclusion complex of AMI with nano-hydrophobic cavity of γ-CD. The stoichiometry of inclusion complex was studied by continuous variation Job's plot method and found 1:1. The binding constant was found 1166.65 M(-1) by Benesi-Hildebrand plot. The molecular docking of AMI and γ-CD was done to investigate complexation. The inclusion complex formation was further confirmed by (1)H NMR and FT-IR, DSC and XRD analysis. The solubility of AMI was increased 3.74 times after inclusion complex formation with γ-CD.
authors: Department of Pharmaceutical Sciences, S Bhagwan Singh PG Institute of Bio-medical Sciences and Research, Balawala, Dehradun 248161, Uttarakhand, India. rx.jnegi@gmail.com
authors: Jeetendra Singh
authors: JS
authors: Negi
authors: Shivpal
authors: S
authors: Singh
mesh_terms: D000077582:Amisulpride; D008958:Models, Molecular; D008968:Molecular Conformation; D013057:Spectrum Analysis; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000737:chemistry; D047408:gamma-Cyclodextrins / Q000737:chemistry*
chemical_list: D047408:gamma-Cyclodextrins; D013469:Sulpiride; D000077582:Amisulpride