title: ABO blood groups and pancreatic cancer risk and survival: results from the PANcreatic Disease ReseArch (PANDoRA) consortium.
abstract: There is strong epidemiologic evidence indicating that common genetic variability             could be implicated in pancreatic cancer risk and, to date, various loci have             been proposed. In particular, there is increasing evidence of the involvement             of ABO gene variability and pancreatic cancer risk. In a large multicentric study             of 1,028 pancreatic ductal adenocarcinoma cases and 2,257 controls in the context             of the PANcreatic Disease ReseArch (PANDoRA) consortium, we investigated the suggested             association with increased risk for carriers of single nucleotide polymorphisms             (SNPs) determining the A or B allele in comparison with the O allele, which encodes             for a non-functional enzyme. Since glycosyltransferase activity, encoded by ABO,             is higher for the A1 variant compared with the A2 variant, we investigated the             hypothesis that A1 carriers were at an increased risk of pancreatic cancer. In             our analysis, carriers of the A1 were indeed at greater risk of developing the             disease. In addition, we investigated the possible influence that genetic variability             at the ABO locus may have in pancreatic cancer survival, but we observed no effect             in our population.
authors: Genomic Epidemiology Group, German Cancer Research Center (DKFZ),                     Heidelberg, Germany.
authors: Cosmeri
authors: C
authors: Rizzato
authors: Daniele
authors: D
authors: Campa
authors: Raffaele
authors: R
authors: Pezzilli
authors: Pavel
authors: P
authors: Soucek
authors: William
authors: W
authors: Greenhalf
authors: Gabriele
authors: G
authors: Capurso
authors: Renata
authors: R
authors: Talar-Wojnarowska
authors: Anette
authors: A
authors: Heller
authors: Krzysztof
authors: K
authors: Jamroziak
authors: Kay-Tee
authors: KT
authors: Khaw
authors: Tim J
authors: TJ
authors: Key
authors: Franco
authors: F
authors: Bambi
authors: Stefano
authors: S
authors: Landi
authors: Beatrice
authors: B
authors: Mohelnikova-Duchonova
authors: Ludmila
authors: L
authors: Vodickova
authors: Markus W
authors: MW
authors: Büchler
authors: Peter
authors: P
authors: Bugert
authors: Pavel
authors: P
authors: Vodicka
authors: John P
authors: JP
authors: Neoptolemos
authors: Jens
authors: J
authors: Werner
authors: Jörg D
authors: JD
authors: Hoheisel
authors: Andrea S
authors: AS
authors: Bauer
authors: Nathalia
authors: N
authors: Giese
authors: Federico
authors: F
authors: Canzian
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000483:Alleles; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D016695:Glycosyltransferases / Q000235:genetics; D006801:Humans; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D000017:ABO Blood-Group System; D016695:Glycosyltransferases