title: A single nucleotide polymorphism in inflammatory gene RNASEL predicts outcome after radiation therapy for localized prostate cancer.
abstract: OBJECTIVE
  To study associations between single nucleotide polymorphisms (SNP) in Ribonuclease L (RNASEL), a gene implicated in inflammation and prostate cancer risk, and outcomes after radiation therapy.
  
  
  METHODS
  We followed participants in the prospective US Health Professionals Follow-Up Study treated with radiation therapy for early-stage prostate cancer. Three SNPs were genotyped based on previously determined functional and biological significance. We used multivariable Cox proportional hazards models to assess per-allele associations with the primary outcome defined as time to a composite endpoint including development of lethal prostate cancer or biochemical recurrence.
  
  
  RESULTS
  We followed 434 patients treated with radiation therapy for a median of 9 years. On multivariate analysis, the rs12757998 variant allele was associated with significantly decreased risk of the composite endpoint [HR: 0.65; 95% confidence interval (CI), 0.45-0.94%; P = 0.02] driven by decreased biochemical recurrence (HR: 0.60; 95% CI, 0.40-0.89%; P = 0.01) and men treated with external beam (HR: 0.58; 95% CI, 0.36-0.93%; P = 0.02). In contrast, in 516 men from the same cohort treated with radical prostatectomy, we found no significant impact of this variant on outcome. Furthermore, the rs12757998 variant allele significantly modified the association between androgen deprivation therapy and outcomes after radiation therapy (p-interaction = 0.02).
  
  
  CONCLUSIONS
  We show an association between RNASEL SNP rs12757998 and outcome after radiation therapy for prostate cancer. This SNP is associated with increased circulating C-reactive protein and interleukin-6, suggesting a potential role for inflammation in the response to radiation. If validated, genetic predictors of outcome may help inform prostate cancer management.
authors: Harvard Radiation Oncology Program, Boston, Massachusetts, USA. jdschoenfeld@partners.org
authors: Jonathan D
authors: JD
authors: Schoenfeld
authors: Danielle N
authors: DN
authors: Margalit
authors: Julie L
authors: JL
authors: Kasperzyk
authors: Irene M
authors: IM
authors: Shui
authors: Jennifer R
authors: JR
authors: Rider
authors: Mara M
authors: MM
authors: Epstein
authors: Allison
authors: A
authors: Meisner
authors: Stacey A
authors: SA
authors: Kenfield
authors: Neil E
authors: NE
authors: Martin
authors: Paul L
authors: PL
authors: Nguyen
authors: Philip W
authors: PW
authors: Kantoff
authors: Edward L
authors: EL
authors: Giovannucci
authors: Meir J
authors: MJ
authors: Stampfer
authors: Lorelei A
authors: LA
authors: Mucci
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000008:administration & dosage; D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor / Q000235:genetics; D002097:C-Reactive Protein / Q000378:metabolism; D004722:Endoribonucleases / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000473:pathology; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D011467:Prostate / Q000601:surgery; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D015850:Interleukin-6; D002097:C-Reactive Protein; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease
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