title: Ectopic antenna induction by overexpression of CG17836/Xrp1 encoding an AT-hook DNA binding motif protein in Drosophila.
abstract: Drosophila imaginal discs are an excellent model system for studies of developmental plasticity. In imaginal discs, most cells adhere strictly to their specific identity, but some cells undergo transdetermination, a process wherein the determined identity switches to another disc-specific identity. In this study, we performed gain-of-function screening and identified a gene, CG17836/Xrp1, that induces ectopic antennae in the eye field upon overexpression at the early eye disc stage. An essential factor in the distalization process, Distalles, and its upstream regulators Wingless, Hedgehog, and Decapentaplegic, are ectopically induced by CG17836/Xrp1 overexpression in eye discs, and this provides molecular evidence of the formation of ectopic antennae. Further, forced expression of CG17836/Xrp1 induced severe cell-proliferation defects. These findings suggest that CG17836/Xrp1 is involved in the regulation of cell proliferation in eye discs and affects disc identity specification.
authors: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
authors: Noriko
authors: N
authors: Tsurui-Nishimura
authors: Thanh Quang
authors: TQ
authors: Nguyen
authors: Tomonori
authors: T
authors: Katsuyama
authors: Tatsurou
authors: T
authors: Minami
authors: Hirofumi
authors: H
authors: Furuhashi
authors: Yoshiteru
authors: Y
authors: Oshima
authors: Shoichiro
authors: S
authors: Kurata
mesh_terms: D000818:Animals; D057506:Arthropod Antennae / Q000254:growth & development / Q000378:metabolism*; D049109:Cell Proliferation; D054338:Cell Transdifferentiation; D054910:Compound Eye, Arthropod / Q000254:growth & development / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D060227:Imaginal Discs / Q000254:growth & development / Q000378:metabolism*; D009024:Morphogenesis / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D051155:Wnt1 Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors; D051155:Wnt1 Protein; C582780:Xrp1 protein, Drosophila; C117261:distal-less protein, insect; C064196:dpp protein, Drosophila; C074622:wg protein, Drosophila; C077245:hh protein, Drosophila