title: Stereotactic radiosurgery for the treatment of brain metastases; results from a single institution experience.
abstract: BACKGROUND
  Stereotactic radiosurgery is frequently used for the treatment of brain metastases. This study provides a retrospective evaluation of patients with secondary lesions of the brain treated with stereotactic radiosurgery (SRS) at our institution.
  
  
  OBJECTIVE
  To provide outcome data from a single institutional experience with SRS and identify any significant prognostic factors in the cohort.
  
  
  METHODS
  Sixty-seven patients received first time SRS to 86 intracranial metastases between 2007 and 2010. Sixteen patients were excluded from this study due to the absence of post-treatment neuroimaging, resulting in 51 patients with 64 treated lesions. Of these patients, 37 (72.5%) received SRS electively, while 14 (27.5%) received salvage SRS after brain metastasis progression following whole brain radiotherapy.
  
  
  RESULTS
  Median survival for the entire group was 15 months from the date of radiosurgery. Patients without active extracranial disease had statistically significant survival time than those with active extracranial disease (P=0.03). 45 (70.3%) lesions achieved local tumour control in 34 patients (66.7%) with a mean follow-up period of 10.7 months (range 1.7-33.6 months, 95 % confidence interval 6.6-9.8 months).
  
  
  CONCLUSIONS
  The results reported in this study equate to those reported in other series consolidating SRS as an effective treatment option with few serious complications. Developments in systemic disease control will see further improvements in overall survival.
authors: UPMC Beacon Cancer Centre, UPMC Beacon Hospital, Sandyford, Dublin, 18, Ireland. burkedfb@gmail.com
authors: D
authors: D
authors: Burke
authors: C
authors: C
authors: Mascott
authors: L
authors: L
authors: Rock
authors: S
authors: S
authors: Callinan
authors: A
authors: A
authors: Mihai
authors: P
authors: P
authors: Thirion
authors: J G
authors: JG
authors: Armstrong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000601:surgery; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D012189:Retrospective Studies; D016879:Salvage Therapy
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