title: Novel one-pot green synthesis of indolizines biocatalysed by Candida antarctica Lipases.
abstract: Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as biocatalysts. As showed by HPLC/MS analysis, the yield in indolizines was higher in the presence of the biocatalyst than in absence of enzyme. Lipase A, from Candida antarctica, showed high catalytic activity and selectivity for the cycloaddition reactions. When the reactions were performed under ultrasound irradiation, the Candida antarctica lipase catalyzed reactions yielded pure indolozines, in good yields and in very short time.
authors: Department of Chemistry, Physics and Environment, Faculty of Science and Environment, Dunarea de Jos University of Galati, 111 Domneasca Street, Galati 800201, Romania. rodinica@ugal.ro
authors: Rodica Mihaela
authors: RM
authors: Dinica
authors: Bianca
authors: B
authors: Furdui
authors: Ioana Otilia
authors: IO
authors: Ghinea
authors: Gabriela
authors: G
authors: Bahrim
authors: Simon
authors: S
authors: Bonte
authors: Martine
authors: M
authors: Demeunynck
mesh_terms: D002175:Candida / Q000145:classification / Q000201:enzymology* / Q000235:genetics; D002384:Catalysis; D004800:Enzymes, Immobilized / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal / Q000502:physiology; D055772:Green Chemistry Technology / Q000379:methods*; D007212:Indolizines / Q000138:chemical synthesis*; D008049:Lipase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D004800:Enzymes, Immobilized; D007212:Indolizines; D008049:Lipase
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