title: Poor reproducibility of allergic rhinitis SNP associations.
abstract: Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese population (948 AR-cases, 580 controls) were analyzed using 49 AR-associated SNPs. The overall pattern of P-values indicated that very few of the investigated SNPs were associated with AR. Given published odds ratios (ORs) most SNPs showed high power to detect an association, but no correlations were found between the ORs of the two study populations or with published ORs. None of the association signals were in common to the two genome-wide association studies published in AR, indicating that the associations represent false positives or have much lower effect-sizes than reported.
authors: Division of ENT Diseases, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
authors: Daniel
authors: D
authors: Nilsson
authors: Anand Kumar
authors: AK
authors: Andiappan
authors: Christer
authors: C
authors: Halldén
authors: Chew Fook
authors: CF
authors: Tim
authors: Torbjörn
authors: T
authors: Säll
authors: De Yun
authors: de Y
authors: Wang
authors: Lars-Olaf
authors: LO
authors: Cardell
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D015203:Reproducibility of Results; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics* / Q000503:physiopathology; D012846:Singapore; D013548:Sweden
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