title: Effect of different degrees of hydrogenated fish oil on intestinal carcinogenesis in Min/+ mice.
abstract: Intake of trans fatty acids from hydrogenated fish oils has been related to increased risk of coronary heart diseases. The possible effect on colorectal carcinogenesis is unclear.
  
  
  METHODS
  Multiple intestinal neoplasia (Min/+) mice were fed one of four experimental diets: either raw fish oil (FO), low (LHFO)-, high (HHFO)- or fully-hydrogenated fish oil (FFHO), from 0 to 9 weeks of age. The number and size of intestinal tumors were recorded.
  
  
  RESULTS
  There was no difference between the intervention groups in the numbers of developed intestinal tumors. The tumor size was statistically significantly lower in HHFO vs. the FO-group in male Min/+ mice. The HHFO and FHFO groups had lower weight gain than did the FO group (p=0.008 and p=0.04, respectively), but gender differences, due to effect of dietary intervention on weight gain, were found in Min/+ mice.
  
  
  CONCLUSIONS
  When compared with raw fish oil, different degrees of hydrogenation of the fish oil had no effect on intestinal carcinogenesis in Min/+ mice.
authors: Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway.  molinmarianne@gmail.com.
authors: Marianne
authors: M
authors: Molin
authors: Paula
authors: P
authors: Berstad
authors: Jurate Saltyte
authors: JS
authors: Benth
authors: Jan
authors: J
authors: Alexander
authors: Jan Erik
authors: JE
authors: Paulsen
authors: Kari
authors: K
authors: Almendingen
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000209:etiology; D000818:Animals; D002471:Cell Transformation, Neoplastic; D004032:Diet / Q000009:adverse effects*; D004041:Dietary Fats / Q000633:toxicity*; D004195:Disease Models, Animal; D005260:Female; D005395:Fish Oils / Q000737:chemistry / Q000633:toxicity*; D006865:Hydrogenation; D007414:Intestinal Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D004041:Dietary Fats; D005395:Fish Oils