title: Does resting echocardiography predict a positive response to subsequent low-dose dobutamine stress echocardiography in patients with ischaemic cardiomyopathy?
abstract: OBJECTIVE
  dobutamine stress echocardiography (DSE) in patients with ischaemic cardiomyopathy. We explored the accuracy of resting echocardiographic and tissue Doppler parameters to predict a positive response by low-dose
  
  
  RESULTS
  We enrolled 100 consecutive patients with prior myocardial infarction, and a left ventricular ejection fraction (LVEF) < 35%. They underwent resting echocardiographic assessment of LVEF, wall motion score index (WMSI), mitral E and A peak velocities, E/A ratio, E peak deceleration time, isovolumetric relaxation time (IVRT), early mitral annular diastolic velocity (e'), and E/e' ratio. Subsequently, they underwent low-dose DSE for assessment of myocardial viability. The presence of viability was defined by improvement of the regional wall motion score by > or =1 grade in > or = 5 myocardial segments, with > or = 20% reduction in WMSI compared with baseline evaluation. Thirty-six patients had a negative response to DSE (group 1); 64 had a positive response (group II). Resting LVEF was higher, and resting WMSI lower in group II versus group I; E peak deceleration time and IVRT shorter in group I (P < 0.05 for all). Multivariable regression analysis identified LVEF, WMSI, and IVRT as the independent predictors of a positive response to DSE. A cutoff value of LVEF of > 25% predicted viability with a sensitivity of 85.9%, specificity 80.6%; WMSI of < or = 2.6 had a sensitivity of 85.7%, specificity 61.1%; IVRT of > 60 msec had a sensitivity of 93.7%, specificity 47.2%.
  
  
  CONCLUSIONS
  Resting LVEF > 25%, WMSI < 2.6, and IVRT > 60 msec predicted viability with a high sensitivity; however, with the exception of LVEF, specificity was quite low.
authors: Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors: Zainab
authors: Z
authors: Abdel-Salam
authors: Wail
authors: W
authors: Nammas
mesh_terms: D000368:Aged; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002316:Cardiotonic Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004280:Dobutamine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D015150:Echocardiography, Doppler / Q000379:methods*; D025401:Echocardiography, Stress / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D013318:Stroke Volume / Q000502:physiology*
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine