title: Early life programming and metabolic syndrome.
abstract: Metabolic syndrome (MS) has reached epidemic proportions worldwide among children. Early life "programming" is now thought to be important in the etiology of obesity, type 2 diabetes, cardiovascular disease and MS. Nutritional imbalance and exposures to endocrine disruptor chemicals during development can increase risk for MS later in life. Epigenetic marks may be reprogrammed in response to both stochastic and environmental stimuli, such as changes in diet and the in utero environment, therefore, determination of targets for early life effects on epigenetic gene regulation provides insight into the molecular mechanisms involved in the epigenetic transgenerational inheritance of a variety of adult onset disease phenotypes. The perinatal period is a crucial time of growth, development and physiological changes in mother and child, which provides a window of opportunity for early intervention that may induce beneficial physiological alternations.
authors: Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China. wangxiumin1019@yahoo.com.cn
authors: Xiu-Min
authors: XM
authors: Wang
mesh_terms: D002648:Child; D047109:Fetal Development / Q000235:genetics / Q000502:physiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000209:etiology* / Q000235:genetics
references: Reprod Domest Anim. 2012 Aug;47 Suppl 4:338-47
references: 22827390
references: Nutrition. 2010 May;26(5):491-501
references: 20097539
references: Diabetes. 2012 Nov;61(11):2833-41
references: 22751689
references: World J Diabetes. 2011 Sep 15;2(9):133-6
references: 21954417
references: J Intern Med. 2007 May;261(5):412-7
references: 17444880
references: Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5449-54
references: 21385945
references: Genome Biol. 2012 Oct 03;13(10):R91
references: 23034163
references: J Environ Public Health. 2012;2012:713696
references: 22991565
references: Metab Syndr Relat Disord. 2013 Apr;11(2):71-80
references: 23249214
references: Diabetes. 2011 May;60(5):1528-34
references: 21471513
references: Environ Health. 2012 Jun 27;11:42
references: 22715989
references: Eur J Clin Nutr. 2012 Feb;66(2):231-6
references: 21970943
references: Diabetologia. 2011 Oct;54(10):2606-14
references: 21779870
references: Mol Cell Endocrinol. 2009 May 25;304(1-2):90-6
references: 19433253
references: World J Diabetes. 2011 Sep 15;2(9):137-48
references: 21954418
references: Prog Biophys Mol Biol. 2011 Jul;106(1):272-80
references: 21219925