title: Correlation between vertical transmission of hepatitis B virus and the expression of HBsAg in ovarian follicles and placenta.
abstract: BACKGROUND
  The aim of this study was to investigate the correlation between the expression of hepatitis B surface antigen (HBsAg) in human ovary and placenta and the vertical transmission of hepatitis B virus (HBV).
  Ovarian and placental tissue specimens of pregnant women infected with HBV were collected during cesarean section and immunostained for HBsAg. The sera of the corresponding newborns were tested for HBV markers and HBV DNA. HBsAg was detected in 15 out of 33 (45%) placental tissues and was further detected in capillary endothelial cells in 4 specimens (26%), of which 3 (75%) corresponding infants were infected with HBV in utero. Out of the 33 ovarian tissues, 7 (21%) were positive for HBsAg, of which 2 (28%) showed HBsAg in ovarian follicles and the 2 corresponding infants (100%) had intrauterine HBV infection.
  
  
  CONCLUSIONS
  HBsAg expression in cells of the ovarian follicle or placental capillary endothelium signal a higher risk for intrauterine HBV infection.
authors: Department of Obstetrics and Gynecology, Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu Province, China. yuminmin324@126.com
authors: Minmin
authors: M
authors: Yu
authors: Qian
authors: Q
authors: Jiang
authors: Xiaojun
authors: X
authors: Gu
authors: Lili
authors: L
authors: Ju
authors: Ying
authors: Y
authors: Ji
authors: Kaihua
authors: K
authors: Wu
authors: Hongxiu
authors: H
authors: Jiang
mesh_terms: D002585:Cesarean Section; D042783:Endothelial Cells / Q000378:metabolism / Q000821:virology; D005260:Female; D006509:Hepatitis B / Q000378:metabolism* / Q000635:transmission* / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000378:metabolism*; D006515:Hepatitis B virus / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D006080:Ovarian Follicle / Q000378:metabolism / Q000821:virology; D010920:Placenta / Q000378:metabolism / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious
chemical_list: D006514:Hepatitis B Surface Antigens
references: World J Gastroenterol. 2005 Sep 28;11(36):5718-20
references: 16237773
references: World J Gastroenterol. 2005 Sep 21;11(35):5565-7
references: 16222757
references: J Virol. 2007 Jul;81(13):7200-7
references: 17442714
references: J Med Virol. 1985 May;16(1):61-6
references: 3840197
references: J Hepatol. 1987 Feb;4(1):37-44
references: 3571932
references: Zhonghua Fu Chan Ke Za Zhi. 2000 Nov;35(11):654-6
references: 11218891
references: World J Gastroenterol. 2004 Feb 1;10(3):437-8
references: 14760774
references: Hum Pathol. 1984 May;15(5):481-4
references: 6373562
references: Nat Genet. 2012 Oct;44(10):1117-21
references: 22922871
references: Mol Reprod Dev. 2005 Jan;70(1):30-6
references: 15515054
references: Arch Gynecol Obstet. 2011 Feb;283(2):317-21
references: 20107823
references: J Int Med Res. 2010 Jan-Feb;38(1):214-9
references: 20233532
references: Ann Hepatol. 2002 Oct-Dec;1(4):192-5
references: 15280806
references: Clin Liver Dis. 2004 May;8(2):403-18
references: 15481347
references: Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Feb;22(1):51-3
references: 18414701
references: Clin Exp Rheumatol. 2008 Jan-Feb;26(1 Suppl 48):S33-8
references: 18570752
references: World J Gastroenterol. 2007 Jul 14;13(26):3625-30
references: 17659715
references: Nephron. 1993;63(1):58-64
references: 8446253
references: Pathol Biol (Paris). 2002 Nov;50(9):568-75
references: 12490422
references: Am J Obstet Gynecol. 2006 Feb;194(2):387-92
references: 16458634
references: World J Gastroenterol. 2004 Nov 1;10(21):3215-7
references: 15457579
references: Zhonghua Liu Xing Bing Xue Za Zhi. 2003 May;24(5):362-5
references: 12820927