title: The effects of extremely low-frequency magnetic fields on melatonin and cortisol, two marker rhythms of the circadian system.
abstract: In the past 30 years the concern that daily exposure to extremely low-frequency magnetic fields (ELF-EMF) (1 to 300 Hz) might be harmful to human health (cancer, neurobehavioral disturbances, etc) has been the object of debate, and has become a public health concern. This has resulted in the classification of ELF-EMF into category 2B, ie, agents that are "possibly carcinogenic to humans" by the International Agency for Research on Cancer. Since melatonin, a neurohormone secreted by the pineal gland, has been shown to possess oncostatic properties, a "melatonin hypothesis" has been raised, stating that exposure to EMF might decrease melatonin production and therefore might promote the development of breast cancer in humans. Data from the literature reviewed here are contradictory. In addition, we have demonstrated a lack of effect of ELF-EMF on melatonin secretion in humans exposed to EMF (up to 20 years' exposure) which rebuts the melatonin hypothesis. Currently, the debate concerns the effects of ELF-EMF on the risk of childhood leukemia in children chronically exposed to more than 0.4 μT. Further research is thus needed to obtain more definite answers regarding the potential deleterious effects of ELF-EMF.
authors: Chronobiology Unit, Foundation A. de Rothschild, Paris, France. yvan.touitou@chronobiology.fr
authors: Yvan
authors: Y
authors: Touitou
authors: Brahim
authors: B
authors: Selmaoui
mesh_terms: D002940:Circadian Rhythm / Q000528:radiation effects*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008550:Melatonin / Q000097:blood*
chemical_list: D008550:Melatonin; D006854:Hydrocortisone
keywords: cancer; chronodisruption; circadian rhythm; cortisol; environment; magnetic field; marker rhythm; melatonin; neurobehavioral disturbances; rhythm desynchronization
references: Cancer Res. 1981 Nov;41(11 Pt 1):4432-6
references: 6796259
references: J Pineal Res. 2001 Aug;31(1):85-8
references: 11485010
references: Bioelectromagnetics. 2001 Jan;22(1):1-6
references: 11122488
references: J Dairy Sci. 1998 Mar;81(3):722-7
references: 9565875
references: Bioelectromagnetics. 2010 Apr;31(3):237-45
references: 19882681
references: Am J Epidemiol. 2001 Oct 1;154(7):591-600
references: 11581092
references: Life Sci. 1989;45(15):1319-32
references: 2677573
references: Am J Epidemiol. 1999 May 1;149(9):831-42
references: 10221320
references: Bioelectromagnetics. 1995;Suppl 3:119-22
references: 8787562
references: Life Sci. 2003 Nov 14;73(26):3339-49
references: 14572876
references: J Dairy Sci. 1996 Sep;79(9):1549-54
references: 8899520
references: Neurosci Lett. 1998 Nov 13;256(3):171-3
references: 9855367
references: Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1529-35
references: 12736182
references: Carcinogenesis. 2001 Jul;22(7):1043-8
references: 11408347
references: N Engl J Med. 1997 Jul 3;337(1):1-7
references: 9203424
references: Life Sci. 1995;57(14):1351-8
references: 7564882
references: Aviat Space Environ Med. 1988 Dec;59(12):1139-45
references: 3071325
references: Neurosci Lett. 2008 Jun 13;438(1):76-9
references: 18472329
references: Bioelectromagnetics. 1998;19(3):172-80
references: 9554695
references: Bioelectromagnetics. 1995;16(6):377-80
references: 8789068
references: Physiol Behav. 2002 Aug;76(4-5):589-95
references: 12126997
references: Int Arch Occup Environ Health. 2002 Mar;75(3):171-8
references: 11954984
references: Cancer Res. 1967 Jul;27(7):1306-11
references: 4952523
references: J Radiat Res. 2005 Sep;46(3):313-8
references: 16210787
references: Biol Reprod. 1993 Oct;49(4):857-64
references: 8218652
references: Cancer Res. 2002 Mar 1;62(5):1356-63
references: 11888905
references: Life Sci. 1988;42(22):2203-6
references: 3374254
references: Bioelectromagnetics. 2004 Apr;25(3):167-75
references: 15042625
references: Am J Epidemiol. 1988 Jul;128(1):21-38
references: 3164167
references: Bioelectromagnetics. 1981;2(2):105-21
references: 6794577
references: Comp Biochem Physiol C Toxicol Pharmacol. 2009 Sep;150(3):372-6
references: 19524062
references: Am J Epidemiol. 1999 Jul 1;150(1):27-36
references: 10400550
references: Chronobiol Int. 2002 Jan;19(1):141-55
references: 11962672
references: Bioelectromagnetics. 1996;17(4):263-73
references: 8891185
references: Adv Drug Deliv Rev. 2010 Jul 31;62(9-10):928-45
references: 20615440
references: Bioelectromagnetics. 2001 Feb;22(2):122-8
references: 11180258
references: Behav Neural Biol. 1981 Jun;32(2):201-13
references: 7283911
references: Neurosci Lett. 1994 Jan 17;166(1):59-62
references: 8190359
references: Life Sci. 1999;64(24):2291-7
references: 10374919
references: Arch Med Res. 2012 Apr;43(3):183-9
references: 22560984
references: Am J Physiol. 1995 May;268(5 Pt 2):R1111-6
references: 7771569
references: Bioelectromagnetics. 2006 Dec;27(8):667-73
references: 16988988
references: Bioelectromagnetics. 2006 Jul;27(5):423-6
references: 16622861
references: J Toxicol Environ Health. 1996 Jun 7;48(2):169-85
references: 8642624
references: Neurology. 1996 Dec;47(6):1477-81
references: 8960730
references: Carcinogenesis. 1996 May;17(5):903-10
references: 8640936
references: J Pineal Res. 1996 Sep;21(2):91-100
references: 8912234
references: Bioelectromagnetics. 1997;18(2):166-71
references: 9084867
references: Bioelectromagnetics. 2001 Apr;22(3):178-84
references: 11255213
references: Acta Endocrinol (Copenh). 1992 Mar;126(3):201-5
references: 1574947
references: Bioelectromagnetics. 1998;19(5):318-29
references: 9669546
references: J Clin Endocrinol Metab. 2003 Dec;88(12):5668-73
references: 14671151
references: Bioelectromagnetics. 1985;6(4):381-9
references: 3836679
references: Environ Res. 2002 Jul;89(3):201-9
references: 12176004
references: Bioelectromagnetics. 2007 Sep;28(6):471-6
references: 17492762
references: Surg Neurol. 1996 Jan;45(1):62-6
references: 9190701
references: Br J Cancer. 2000 Sep;83(5):692-8
references: 10944614
references: J Sleep Res. 1999 Mar;8(1):77-81
references: 10188140
references: Biochim Biophys Acta. 1992 Oct 6;1137(1):59-64
references: 1382609
references: J Occup Environ Med. 1996 Nov;38(11):1108-10
references: 8941900
references: Bioelectromagnetics. 1994;15(5):427-37
references: 7802710
references: Scand J Work Environ Health. 1998 Jun;24(3):183-9
references: 9710370
references: J Pineal Res. 1993 Mar;14(2):89-97
references: 8320637
references: Oncology. 1994 May-Jun;51(3):288-95
references: 8196914
references: Cancer Causes Control. 2006 May;17(4):547-52
references: 16596309
references: Biochem Biophys Res Commun. 1997 May 29;234(3):707-11
references: 9175780
references: J Pineal Res. 2001 Oct;31(3):234-41
references: 11589758
references: Bioelectromagnetics. 1981;2(4):371-80
references: 7326058
references: Pathophysiology. 2009 Aug;16(2-3):149-56
references: 19278839
references: Bioelectromagnetics. 1994;15(5):489-92
references: 7802715
references: Bioelectromagnetics. 2001 Feb;22(2):138-43
references: 11180260
references: Science. 1980 Dec 12;210(4475):1267-9
references: 7434030
references: J Occup Environ Med. 2000 Feb;42(2):136-42
references: 10693073
references: Physiol Chem Phys. 1979;11(5):395-403
references: 542502
references: Life Sci. 1997;61(5):473-86
references: 9247317
references: Int J Radiat Biol. 2002 Nov;78(11):1029-36
references: 12456290
references: Bioelectromagnetics. 2002 Apr;23(3):245-8
references: 11891755
references: Cancer Res. 1963 Oct;23:1545-8
references: 14072694
references: Neurosci Lett. 1994 Feb 28;168(1-2):205-8
references: 8028776
references: J Pineal Res. 1990;9(4):259-69
references: 2096195
references: J Mammary Gland Biol Neoplasia. 2011 Sep;16(3):235-45
references: 21773809
references: J Pineal Res. 1998 Sep;25(2):116-27
references: 9755033
references: Am J Epidemiol. 1979 Mar;109(3):273-84
references: 453167
references: Bioelectromagnetics. 2008 Apr;29(3):169-76
references: 18027843
references: Int J Occup Environ Health. 1996 Jan;2(1):37-47
references: 9933863
references: J Biol Rhythms. 1998 Feb;13(1):52-9
references: 9486843
references: Acta Anat (Basel). 1992;143(4):289-93
references: 1323903
references: Environ Res. 1994 Apr;65(1):149-60
references: 8162882
references: J Pineal Res. 2001 Sep;31(2):109-13
references: 11555165
references: Int J Radiat Biol. 2003 Jun;79(6):431-5
references: 12963545
references: IARC Monogr Eval Carcinog Risks Hum. 2002;80:1-395
references: 12071196
references: Environ Health Perspect. 1996 Mar;104 Suppl 1:135-40
references: 8722117
references: Brain Res Bull. 2010 Jan 15;81(1):92-9
references: 19883742
references: Life Sci. 1998;62(14):1271-80
references: 9570342
references: Int J Epidemiol. 1982 Dec;11(4):345-55
references: 7152787
references: Bioelectromagnetics. 1995;Suppl 3:111-8
references: 8787561
references: Exp Gerontol. 1999 Sep;34(6):733-40
references: 10579634
references: Br J Ind Med. 1989 Oct;46(10):729-37
references: 2818960
references: J Magn Reson Imaging. 1994 Jan-Feb;4(1):7-11
references: 8148559
references: Life Sci. 1996;58(18):1539-49
references: 8649183
references: Bioelectromagnetics. 1997;18(8):555-62
references: 9383244
references: Neuroimmunomodulation. 2001;9(2):65-77
references: 11549888
references: Radiat Res. 1998 Nov;150(5):557-67
references: 9806598
references: Emerg Health Threats J. 2012;5:
references: 22529876
references: J Pineal Res. 1991 Apr;10(3):109-16
references: 1715400
references: Br J Cancer. 1996 Oct;74(8):1248-52
references: 8883412
references: Bioelectromagnetics. 2001 Dec;22(8):581-8
references: 11748676
references: Environ Res. 2001 Feb;85(2):115-21
references: 11161661
references: J Occup Environ Med. 2007 Oct;49(10):1149-56
references: 18000420
references: Bioelectromagnetics. 1999;20(4):224-32
references: 10230936
references: Lancet. 1981 Feb 14;1(8216):383-4
references: 6110011
references: J Pineal Res. 1994 Apr;16(3):136-44
references: 7932036
references: J Pineal Res. 2000 Nov;29(4):228-33
references: 11068945
references: Pathol Biol (Paris). 1996 Jun;44(6):487-95
references: 8977906
references: J Endocrinol. 1983 Jan;96(1):53-64
references: 6822782
references: Bioelectromagnetics. 2004 May;25(4):308-12
references: 15114640
references: Biol Reprod. 1996 Aug;55(2):455-60
references: 8828855
references: Bioelectromagnetics. 1998;19(2):123-7
references: 9492170
references: J Anim Sci. 1995 Nov;73(11):3274-80
references: 8586584
references: Br J Cancer. 2010 Sep 28;103(7):1128-35
references: 20877339
references: Am J Physiol. 1996 May;270(5 Pt 1):E816-21
references: 8967470
references: J Pineal Res. 2000 Jan;28(1):1-8
references: 10626595
references: Bioelectromagnetics. 1997;18(2):190-2
references: 9084872
references: Am J Epidemiol. 2001 Oct 1;154(7):601-9
references: 11581093
references: Bioelectromagnetics. 2004 Oct;25(7):508-15
references: 15376244
references: Bioelectromagnetics. 1988;9(1):95-104
references: 3345217
references: Bioelectromagnetics. 2003 Jan;24(1):12-20
references: 12483661
references: Bioelectromagnetics. 1986;7(2):239-42
references: 3741497
references: Biol Psychiatry. 1984 Aug;19(8):1215-28
references: 6498244
references: Neuro Endocrinol Lett. 2005 Apr;26(2):136-42
references: 15855885
references: Invest Radiol. 1991 Dec;26(12):1095-100
references: 1765445
references: Environ Res. 1991 Aug;55(2):188-98
references: 1651225
references: Ann Epidemiol. 2006 Aug;16(8):622-31
references: 16458540
references: Bioelectromagnetics. 2010 Feb;31(2):89-101
references: 19650076
references: Reprod Toxicol. 2001 Jan-Feb;15(1):49-59
references: 11137378
references: Bioelectromagnetics. 1995;16(2):119-23
references: 7612027
references: Bioelectromagnetics. 1993;14(2):97-106
references: 8494560
references: J Endocrinol. 1982 May;93(2):201-10
references: 7086322
references: J Pineal Res. 2000 Mar;28(2):97-104
references: 10709971
references: Environ Health Perspect. 1999 Nov;107(11):901-4
references: 10544158
references: Bioelectromagnetics. 2003 Feb;24(2):118-24
references: 12524678
references: Eur J Endocrinol. 1994 May;130(5):472-7
references: 8180675
references: Bull Acad Natl Med. 2011 Oct;195(7):1527-46; discussion 1547-9
references: 22812159
references: Curr Genomics. 2009 Apr;10(2):86-92
references: 19794880
references: J Cancer Res Clin Oncol. 1995;121(3):181-8
references: 7713990