title: Synthesis of optically pure 2-trifluoromethyl lactic acid by asymmetric hydroformylation.
abstract: By utilizing Rh catalysts ligated by the P-chirogenic ligands QuinoxP* and DuanPhos, 3,3,3-trifluoroprop-1-en-2-yl acetate could be hydroformylated and subsequently oxidized to yield enantiomerically pure 2-trifluoromethyllactic acid.
authors: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors: Xiao
authors: X
authors: Wang
authors: Stephen L
authors: SL
authors: Buchwald
mesh_terms: D000085:Acetates / Q000737:chemistry*; D019344:Lactic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D055620:Optical Phenomena; D013237:Stereoisomerism
chemical_list: D000085:Acetates; C557357:alpha-(trifluoromethyl)lactic acid; D019344:Lactic Acid