title: Functional connectivity fMRI in mouse brain at 7T using isoflurane.
abstract: Although many resting state fMRI human studies have been published, the number of such rodent studies is considerably less. The reason for this is the severe technical challenge of high magnetic field small rodent imaging. Local magnetic field susceptibility changes at air tissue boundaries cause image distortion and signal losses. The current study reports measures of functional connectivity in mice using only isoflurane for the anesthetic. Because all anesthetic agents will alter cerebral blood flow and cerebral metabolism, the impact these changes have on neuronal connectivity has yet to be fully understood, however this work reports for the first time that reliable functional connectivity measures in mouse brain can be obtained with isoflurane.
authors: Center for Advanced Brain Imaging, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA. dguilfoyle@nki.rfmh.org
authors: David N
authors: DN
authors: Guilfoyle
authors: Scott V
authors: SV
authors: Gerum
authors: Jamie L
authors: JL
authors: Sanchez
authors: Andrea
authors: A
authors: Balla
authors: Henry
authors: H
authors: Sershen
authors: Daniel C
authors: DC
authors: Javitt
authors: Matthew J
authors: MJ
authors: Hoptman
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D059907:Functional Neuroimaging / Q000379:methods*; D007530:Isoflurane / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009415:Nerve Net / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane
references: Neurosci Lett. 2011 Jun 22;497(2):69-73
references: 21530613
references: Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3979-84
references: 22355129
references: J Neurosci Methods. 2008 Mar 30;169(1):249-54
references: 18190970
references: PLoS One. 2012;7(3):e32645
references: 22427858
references: Annu Rev Clin Psychol. 2012;8:49-76
references: 22224834
references: Curr Opin Neurol. 2008 Aug;21(4):424-30
references: 18607202
references: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
references: 11209064
references: J Affect Disord. 2012 Jun;139(1):56-65
references: 22425432
references: NMR Biomed. 2006 Feb;19(1):108-15
references: 16411168
references: Anesth Analg. 1991 Dec;73(6):753-7
references: 1952176
references: PLoS One. 2011 Jan 20;6(1):e16322
references: 21283729
references: Cereb Cortex. 2009 Oct;19(10):2209-29
references: 19221144
references: PLoS One. 2011 Apr 18;6(4):e18876
references: 21533116
references: PLoS One. 2010 Dec 20;5(12):e15710
references: 21187930
references: Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734-9
references: 20176931
references: Neuroimage. 2006 Feb 15;29(4):1359-67
references: 16260155
references: Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1942-7
references: 19171889
references: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
references: 15976020
references: Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53
references: 16945915
references: Magn Reson Med. 1995 Oct;34(4):537-41
references: 8524021
references: Comput Biomed Res. 1996 Jun;29(3):162-73
references: 8812068
references: Nature. 2007 May 3;447(7140):83-6
references: 17476267
references: Magn Reson Med. 1993 Jun;29(6):804-11
references: 8350724
references: Neuroimage. 2008 Jan 1;39(1):248-60
references: 17904868
references: Magn Reson Med. 1996 Oct;36(4):643-5
references: 8892220