title: Serum angiopoietin-related growth factor (AGF) levels are elevated in gestational diabetes mellitus and associated with insulin resistance.
abstract: OBJECTIVE
  Angiopoietin-related growth factor (AGF) is associated with angiogenesis but it can also affect glucose and energy metabolism. The aim of the study was to determine AGF levels in gestational diabetes mellitus (GDM).
  
  
  METHODS
  The study included 44 patients with GDM (GDM group) and 33 non-diabetic, healthy women in the third trimester of pregnancy (control group). We analyzed serum levels of AGF and other biochemical and anthropometric markers in all subjects.
  
  
  RESULTS
  The study revealed that serum AGF levels were significantly higher in patients with GDM (113.30 +/- 69.92 ng/ml) than in controls (52.30 +/- 35.59 ng/ml), (p-value<0.001). Fasting glucose (117.59 vs. 82.18), homeostasis model of assessment - insulin resistance (HOMA-IR), (2.91 vs. 1.75) diastolic (74.20 vs. 70.00) and mean (89.09 vs. 84.84) blood pressure were found to be significantly higher in the GDM group when compared to the control group (p-value<0.05). There was a significant positive association between AGF and HOMA-IR in the GDM group.
  
  
  CONCLUSIONS
  Although gestational diabetes mellitus can be a predictor of serum AGF level, further studies are needed to explain the physiologic roles of AGF in glucose metabolism.
authors: Cumhuriyet University School of Medicine, Department of Gynecology and Obstetrics, Turkey.
authors: Boztosun
authors: B
authors: Abdullah
authors: Köksal
authors: K
authors: Deveci
authors: Remzi
authors: R
authors: Atilgan
authors: Fatih
authors: F
authors: Kiliçli
authors: Melike Sinem
authors: MS
authors: Söylemez
mesh_terms: D000328:Adult; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D012307:Risk Factors; D016387:Women's Health; D055815:Young Adult
chemical_list: C477601:ANGPTL6 protein, human; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D015415:Biomarkers; D001786:Blood Glucose