title: Synthesis of spiro[dihydropyridine-oxindoles] via three-component reaction of arylamine, isatin and cyclopentane-1,3-dione.
abstract: A fast and convenient protocol for the synthesis of novel spiro[dihydropyridine-oxindole] derivatives in satisfactory yields was developed by the three-component reactions of arylamine, isatin and cyclopentane-1,3-dione in acetic acid at room temperature. On the other hand the condensation of isatin with two equivalents of cyclopentane-1,3-dione gave 3,3-bis(2-hydroxy-5-oxo-cyclopent-1-enyl)oxindole in high yields. The reaction mechanism and substrate scope of this novel reaction is briefly discussed.
authors: College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors: Yan
authors: Y
authors: Sun
authors: Jing
authors: J
authors: Sun
authors: Chao-Guo
authors: CG
authors: Yan
keywords: arylamine; cyclopentanedione; isatin; multicomponent reaction; spiro compound
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