title: Sesquiterpenes from the rhizomes of Curcuma heyneana.
abstract: Four new germacranes [heyneanones A-D (1-4)], three new guaianes [4,10-epizedoarondiol (5), 15-hydroxyprocurcumenol (6), 12-hydroxycurcumenol (7)], and two new spirolactones [curcumanolides C (8) and D (9)] were isolated from the rhizomes of Curcuma heyneana together with 13 known sesquiterpenes and two known labdane-type diterpenes. Among the isolated compounds, heyneanone A (1), heyneanone C (3), 4,10-epizedoarondiol (5), procurcumenol (16), aerugidiol (17), zerumin A (23), and (E)-15,16-bisnorlabda-8(17),11-dien-13-one (24) inhibited protein tyrosine phosphatase 1B (PTP1B) with IC(50) values of 42.5, 35.2, 35.1, 45.6, 35.7, 10.4, and 14.7 μM, respectively.
authors: Division of Natural Product Chemistry, Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan.
authors: Azis
authors: A
authors: Saifudin
authors: Ken
authors: K
authors: Tanaka
authors: Shigetoshi
authors: S
authors: Kadota
authors: Yasuhiro
authors: Y
authors: Tezuka
mesh_terms: D030024:Curcuma / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D012717:Sesquiterpenes; C438916:procurcumenol; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1