title: Kasabach-Merritt phenomenon: a report of 11 cases from a single institution.
abstract: BACKGROUND
  Kasabach-Merritt phenomenon (KMP) is a rare condition and optimal treatments have not yet been established, especially for cases that are unresponsive to first-line therapy. We retrospectively reviewed 11 KMP cases treated over the past 13 years in our institute.
  
  
  METHODS
  With the exception of 1 case, steroids were administered as the first-line therapy. Eight cases required second-line or third-line therapy. The effective salvage therapies include interferon (n=1), radiotherapy (n=1), and chemotherapy (n=5). One case continues to depend upon chemotherapy. Three refractory cases were therapy dependent over 1 year of age, whereas 8 were treated effectively by 6 months of age.
  
  
  CONCLUSIONS
  Chemotherapy seems to be the most effective therapy for steroid-resistant KMP cases.
authors: Departments of *Hematology/Oncology †Radiology ‡Pathology §Division of Plastic Surgery, Saitama Children's Medical Center, Magome, Saitama, Japan.
authors: Naoko
authors: N
authors: Yasui
authors: Katsuyoshi
authors: K
authors: Koh
authors: Motohiro
authors: M
authors: Kato
authors: Myoung-ja
authors: MJ
authors: Park
authors: Daisuke
authors: D
authors: Tomizawa
authors: Koichi
authors: K
authors: Oshima
authors: Naoki
authors: N
authors: Uchisaka
authors: Yoshihiro
authors: Y
authors: Gocho
authors: Ayumu
authors: A
authors: Arakawa
authors: Masafumi
authors: M
authors: Seki
authors: Eiji
authors: E
authors: Oguma
authors: Hiroshi
authors: H
authors: Kishimoto
authors: Shoji
authors: S
authors: Watanabe
authors: Akira
authors: A
authors: Kikuchi
authors: Ryoji
authors: R
authors: Hanada
mesh_terms: D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D059885:Kasabach-Merritt Syndrome / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome