title: [Fat distribution and its relationship with genetic polymorphism in patients with nonalcoholic liver disease].
abstract: The article presents the results of research which demonstrated that the features of fat distribution in patients with non-alcoholic fatty liver disease (NAFLD), which depended on the sex and the activity of alanine transaminase. It is shown that carriers G allele rs6666089ADIPOR1 had significantly higher levels of visceral, subcutaneous adipose tissue and their relation and% liver fat in the compared with carriers A allele. The findings suggest that the development of more severe hepatic steatosis in carriers of GG genotype of rs6666089 ADIPOR1, confirming participation in the formation of ectopic fat NAFLD.
authors: GI L.T. Malaya Therapy Institute of the NAMS Ukraine, Kharkov, Ukraine.
authors: O
authors: O
authors: Kolesnikova
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood / Q000235:genetics; D001835:Body Weight / Q000235:genetics; D016022:Case-Control Studies; D005234:Fatty Liver / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D006720:Homozygote; D006801:Humans; D050152:Intra-Abdominal Fat / Q000502:physiology*; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D020641:Polymorphism, Single Nucleotide; D054419:Receptors, Adiponectin / Q000235:genetics*; D050151:Subcutaneous Fat / Q000502:physiology*; D050507:Subcutaneous Fat, Abdominal / Q000502:physiology*
chemical_list: C475418:ADIPOR1 protein, human; D054419:Receptors, Adiponectin; D000410:Alanine Transaminase