title: Comparison of two techniques using hyaluronic acid to correct the tear trough deformity.
abstract: BACKGROUND
  Hyaluronic acid (HA) can be used to correct volume loss associated with periorbital aging.
  
  
  OBJECTIVE
  To report and compare the efficacy and safety of HA used to treat tear trough deformities with two different injection techniques.
  
  
  METHODS
  This is a retrospective, single-center study of 81 patients comparing the two injection techniques used for the treatment of tear trough deformities from 2003 to 2011. Hyaluronic acid was administered either in a single depot in the nasojugal groove and massaged into position or in multiple small aliquots along the inferior orbital rim and massaged into position. Patient satisfaction and the incidence of adverse reactions were evaluated.
  
  
  RESULTS
  Of the 194 patients treated during the study period, 81 (42%) were successfully contacted. The overall patient satisfaction with the correction was similar for both techniques. Two patients treated with a single depot of HA were later given hyaluronidase, but otherwise, there was no statistically significant difference in the incidence and severity of side effects.
  
  
  CONCLUSIONS
  We describe and compare an alternative technique for the correction of tear trough deformity using a single deposition of HA in the nasojugal groove with favorable outcomes.
authors: Department of Dermatology, University of California San Diego, CA, USA. shane.hamman@gmail.com
authors: M Shane
authors: MS
authors: Hamman
authors: Mitchel P
authors: MP
authors: Goldman
authors: Sabrina G
authors: SG
authors: Fabi
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D003357:Cosmetic Techniques; D003692:Delayed-Action Preparations; D005145:Face; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use; D007267:Injections; D007765:Lacrimal Apparatus / Q000002:abnormalities*; D007766:Lacrimal Apparatus Diseases / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009915:Orbit; D017060:Patient Satisfaction; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D003692:Delayed-Action Preparations; D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase