title: Sex- and endocrine-stage-differences in middle-aged rats in an animal model of OCD.
abstract: Various clinical studies suggest that many features of OCD are influenced by sex, age and fluctuations in hormonal levels. Animal models have confirmed these differences, and suggest they are mediated by the serotonergic system. We compared the perseveration behavior in a T-maze after the administration of the 5-HT1A agonist, 8-OH-DPAT (2.0 mg/kg) and the preventive action of subchronic fluoxetine (10 mg/kg, 3 times) in middle-aged (11-14 months) males and female rats in two endocrine states: irregular cycles (tested in diestrus) or persistent diestrus. After 8-OH-DPAT, females with persistent diestrus presented higher perseveration scores than males and females with irregular cycles. Fluoxetine produced an anticompulsive-like effect only in females with persistent diestrus. Females in persistent diestrus showed higher estradiol levels than those in irregular cycles or males. In all groups 8-OH-DPAT increased ambulation and fluoxetine did not modify this action. In males, the combined administration of fluoxetine and 8-OH-DPAT impaired motor coordination. Data are discussed on the basis of estradiol levels and sex differences.
authors: Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados, Mexico.
authors: Sandra
authors: S
authors: Olvera-Hernández
authors: Roberto
authors: R
authors: Chavira
authors: Alonso
authors: A
authors: Fernández-Guasti
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000633:toxicity; D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D004703:Endocrine System / Q000187:drug effects / Q000378:metabolism*; D004958:Estradiol / Q000097:blood; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D009771:Obsessive-Compulsive Disorder / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D045442:Rotarod Performance Test; D017366:Serotonin Receptor Agonists / Q000633:toxicity; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012727:Sex Characteristics
chemical_list: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D004958:Estradiol; D005473:Fluoxetine; D005640:Follicle Stimulating Hormone; D007986:Luteinizing Hormone; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors