title: A two-step drug repositioning method based on a protein-protein interaction network of genes shared by two diseases and the similarity of drugs.
abstract: The present study proposed a two-step drug repositioning method based on a protein-protein interaction (PPI) network of two diseases and the similarity of the drugs prescribed for one of the two. In the proposed method, first, lists of disease related genes were obtained from a meta-database called Genotator. Then genes shared by a pair of diseases were sought. At the first step of the method, if a drug having its target(s) in the PPI network, the drug was deemed a repositioning candidate. Because targets of many drugs are still unknown, the similarities between the prescribed drugs for a specific disease were used to infer repositioning candidates at the second step. As a first attempt, we applied the proposed method to four different types of diseases: hypertension, diabetes mellitus, Crohn disease, and autism. Some repositioning candidates were found both at the first and second steps.
authors: Department of Electrical Engineering, Faculty of Engineering, Kogakuin University, 1-24-2 Nishi-Shinjuku, Shinjuku, Tokyo 163-8677, Japan.
authors: Yutaka
authors: Y
authors: Fukuoka
authors: Daiki
authors: D
authors: Takei
authors: Hisamichi
authors: H
authors: Ogawa
keywords: Disease related genes; Drug interaction; Drug repositioning; Drug target; Protein-Protein interaction network; Side effect; Substructure
references: Postgrad Med J. 1988;64 Suppl 3:39-47; discussion 48-9
references: 3074296
references: Nat Protoc. 2009;4(1):44-57
references: 19131956
references: Science. 2009 Jun 12;324(5933):1394-5
references: 19520944
references: Genome Res. 2003 Nov;13(11):2498-504
references: 14597658
references: Nucleic Acids Res. 2011 Jan;39(Database issue):D561-8
references: 21045058
references: PLoS Comput Biol. 2012;8(5):e1002503
references: 22589709
references: BMC Med Genomics. 2010 Oct 29;3:50
references: 21034472
references: Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41
references: 21059682
references: Clin Pharmacol Ther. 2009 Nov;86(5):507-10
references: 19571805
references: PLoS One. 2011;6(12):e28025
references: 22205936