title: A single dose of amoxicillin and dexamethasone for prevention of postoperative complications in third molar surgery: a randomized, double-blind, placebo controlled clinical trial.
abstract: BACKGROUND
  The aim of this study was to assess the efficacy of a single prophylactic dose of amoxicillin and/or dexamethasone in preventing postoperative complications (PC) after a surgical removal of a single mandibular third molar (M3).
  
  
  METHODS
  This study is a randomized, placebo controlled clinical trial. Four groups were included: Group 1 (G1) included a prophylactic dose of 2 g of amoxicillin and 8 mg of dexamethasone; Group 2 (G2) included a prophylactic dose of 2 g of amoxicillin and 8 mg of placebo; Group 3 (G3) included a prophylactic dose of 8 mg of dexamethasone and 2 g of placebo and; Group 4 (G4) placebo.
  
  
  RESULTS
  Fifty patients were included. It was observed one case of alveolar infection (2%) and two of alveolar osteitis (4%) resulting in three PC (6%). No statistical differences were observed between therapeutic groups for development of PC, trismus, pain and edema. The use of antibiotics showed an absolute risk reduction (ARR) for PC development of 3.52% and the number needed to treat (NNT) was 29.
  
  
  CONCLUSIONS
  Prophylactic antibiotics and corticoid in a single dose regimen did not bring any benefit on M3 surgeries.
authors: School of Dentistry, Health Bioscience Postgraduate Program, Tissue Aspects for Health Prognosis and Intervention Laboratory (LAPROG), Oeste de Santa Catarina University (UNOESC), Brazil.
authors: Marcelo Carlos
authors: MC
authors: Bortoluzzi
authors: Diogo Lenzi
authors: DL
authors: Capella
authors: Tharzon
authors: T
authors: Barbieri
authors: Micheli
authors: M
authors: Pagliarini
authors: Talita
authors: T
authors: Cavalieri
authors: Rafael
authors: R
authors: Manfro
keywords: Amoxicillin; Antibiotic prophylaxis; Dexamethasone; Third molar surgery
references: Int J Oral Maxillofac Surg. 2008 Mar;37(3):260-3
references: 18296027
references: J Oral Maxillofac Surg. 2008 Nov;66(11):2213-8
references: 18940482
references: J Oral Maxillofac Surg. 2005 Jul;63(7):1021-5
references: 16003632
references: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Dec;104(6):757-62
references: 17764988
references: Med Oral Patol Oral Cir Bucal. 2006 Mar 01;11(2):E188-205
references: 16505802
references: J Oral Maxillofac Surg. 2007 Nov;65(11):2218-26
references: 17954317
references: Int J Oral Maxillofac Surg. 2007 Apr;36(4):321-7
references: 17229548
references: Br J Oral Maxillofac Surg. 2008 Mar;46(2):133-5
references: 17188409
references: Med Oral Patol Oral Cir Bucal. 2010 Jul 01;15(4):e633-8
references: 20173715
references: J Oral Maxillofac Surg. 2008 May;66(5):893-9
references: 18423277
references: Oral Maxillofac Surg. 2011 Dec;15(4):217-23
references: 21845387
references: Oral Maxillofac Surg Clin North Am. 2011 Nov;23(4):541-6, vi
references: 21982606
references: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Jul;100(1):e11-8
references: 15953905
references: J Oral Maxillofac Surg. 2007 Oct;65(10):1909-21
references: 17884515
references: Aust Dent J. 2010 Dec;55(4):462-7
references: 21174921
references: J Oral Maxillofac Surg. 2007 Oct;65(10):1977-83
references: 17884525
references: Mymensingh Med J. 2006 Jul;15(2):142-5
references: 16878093
references: Br J Oral Maxillofac Surg. 2004 Dec;42(6):555-8
references: 15544888
references: J Contemp Dent Pract. 2011 Jul 01;12(4):239-44
references: 22186857
references: J Oral Maxillofac Surg. 2009 Feb;67(2):286-91
references: 19138601
references: J Oral Maxillofac Surg. 2008 Nov;66(11):2276-83
references: 18940492
references: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Oct;90(4):406-15
references: 11027375
references: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Aug;102(2):e4-11
references: 16876044
references: J Oral Maxillofac Surg. 2007 Sep;65(9):1700-6
references: 17719386
references: J Oral Maxillofac Surg. 2009 Jul;67(7):1467-72
references: 19531419
references: J Oral Maxillofac Surg. 2011 Nov;69(11):e333-9
references: 21802822
references: Oral Maxillofac Surg Clin North Am. 2007 Feb;19(1):117-28, vii
references: 18088870
references: Int J Oral Maxillofac Surg. 2010 Feb;39(2):107-14
references: 20117915
references: J Craniofac Surg. 2011 Mar;22(2):551-3
references: 21403575
references: J Oral Maxillofac Surg. 2007 Sep;65(9):1685-92
references: 17719384