title: hESC-derived pancreatic progenitors.
abstract: Successful derivation of pancreatic progenitors from human embryonic stem cells (hESCs) in vitro and further differentiation towards functional β cells in vivo may create the possibility of using hESC-derived pancreatic progenitors (PPs), instead of derived β cells, as an alternative transplantable source in β cell replacement therapy. Here we discuss present approaches, as well as future alternatives, in the fields of basic and clinic research on β cell differentiation, derivation and transplantation.
authors: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
authors: Lina
authors: L
authors: Sui
authors: Guang-Hui
authors: GH
authors: Liu
authors: Juan Carlos
authors: JC
authors: Izpisua Belmonte
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D051927:CD24 Antigen / Q000378:metabolism; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000166:cytology; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010179:Pancreas / Q000166:cytology*; D013925:Thromboplastin / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051927:CD24 Antigen; D009419:Nerve Tissue Proteins; D013925:Thromboplastin; C498695:NEUROG3 protein, human
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