title: Expression of apoptosis in placenta of experimental antiphospholipid syndrome mouse.
abstract: OBJECTIVE
  To study the histopathology and expression of apoptosis in placenta of pregnancy-complicated antiphospholipid syndrome (APS)-positive mouse models.
  
  
  METHODS
  ICR mice were immunized with IgG isotype of human anticardiolipin (aCL) and/or lupus anticoagulant (LA). The pathological and apoptotic expression was studied in the placenta of positive APS mice and compared with respective control samples.
  
  
  RESULTS
  Mice with passive immunization of human aCL and/or LA produced an increase in fetal resorption along with markedly induced thrombosis in the placenta associated with increased placental apoptosis. In addition, fewer mitotic cells, less trophoblast giant cell invasion, and more shrunken cells in the deciduas were seen.
  
  
  CONCLUSIONS
  Our study showed the pathogenic role of aCL and LA in pregnancy complications.
authors: Department of Bio-Medical Science, School of Basic Medical Sciences, Bharathidasan University, Tiruchirappalli, Tamil nadu, India.
authors: Shanmugam
authors: S
authors: Velayuthaprabhu
authors: Hidehiko
authors: H
authors: Matsubayashi
authors: Toshitaka
authors: T
authors: Sugi
authors: Masato
authors: M
authors: Nakamura
authors: Yasuyuki
authors: Y
authors: Ohnishi
authors: Tomoyuki
authors: T
authors: Ogura
authors: Govindaraju
authors: G
authors: Archunan
mesh_terms: D000818:Animals; D017153:Antibodies, Anticardiolipin / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000276:immunology* / Q000473:pathology; D017209:Apoptosis / Q000276:immunology; D005260:Female; D005327:Fetal Resorption / Q000276:immunology; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000008:administration & dosage / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D023421:Models, Animal; D010920:Placenta / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology* / Q000473:pathology; D013927:Thrombosis / Q000276:immunology
chemical_list: D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor