title: [Local fibrinolysis in treatment of non-traumatic intracerebral hematomas and ventricular hemorrhages].
abstract: Local fibrinolysis and aspiration in treatment of spontaneous intracerebral hematomas (SIH) and ventricular hemorrhages (VH) have become a wide spread technique in dedicated cerebrovascular centers. Forty four patients treated in Burdenko NSI in 2007-2011 were evaluated. Local fibrinolysis for SIH were perfomed in 30 pt., for isolated VH in 14. Puroplazan, a prourokinaze based derivative (mean dose - 50 000 ME) were used in 36 cases, Actilyse (tPA) (2.0 g mean) in 8 cases. Status at discharge was improved in 66.7% of patients with SIH and 57.1% of patients with isolated VH. Mortality comprised to 10 and 28.6% correspondingly. Local hematoma aspiration and fibrinolysis is an effective minimally-invasive method of primary and secondary non-traumatic SIH and VH evacuation. Dose of fibrinolytic agent should be selected individually and depends on hematoma volume. Applied dose clinically-wise should be decreased along with reducing of hematoma size and number of injections to minimize recurrent hemorrhage risk.
authors: Iu V
authors: IuV
authors: Pilipenko
authors: Sh Sh
authors: ShSh
authors: Éliava
authors: O D
authors: OD
authors: Shekhtman
authors: A S
authors: AS
authors: Kheĭreddin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005342:Fibrinolysis; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D046648:Hematoma, Subdural, Intracranial / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D014568:Urokinase-Type Plasminogen Activator; C067551:saruplase