title: From pancreatic islet formation to beta-cell regeneration.
abstract: Diabetes mellitus represents a major healthcare burden and, due to the increasing prevalence of type I diabetes and the complications arising from current treatments, other alternative therapies must be found. Type I diabetes arises as a result of a cell-mediated autoimmune destruction of insulin producing pancreatic β-cells. Thus, a cell replacement therapy would be appropriate, using either in vitro or in vivo cell differentiation/reprogramming from different cell sources. Increasing our understanding of the molecular mechanisms controlling endocrine cell specification during pancreas morphogenesis and gaining further insight into the complex transcriptional network and signaling pathways governing β-cell development should facilitate efforts to achieve this ultimate goal, that is to regenerate insulin-producing β-cells. This review will therefore describe briefly the genetic program underlying mouse pancreas development and present new insights regarding β-cell regeneration.
authors: Université de Nice-Sophia Antipolis, FR-06108 Nice, France; Inserm U1091, IBV, Diabetes Genetics Team, FR-06108 Nice, France; JDRF, 26 Broadway, NY-10004, USA.
authors: Nouha
authors: N
authors: Ben-Othman
authors: Université de Nice-Sophia Antipolis, FR-06108 Nice, France; Inserm U1091, IBV, Diabetes Genetics Team, FR-06108 Nice, France; JDRF, 26 Broadway, NY-10004, USA.
authors: Monica
authors: M
authors: Courtney
authors: Université de Nice-Sophia Antipolis, FR-06108 Nice, France; Inserm U1091, IBV, Diabetes Genetics Team, FR-06108 Nice, France; JDRF, 26 Broadway, NY-10004, USA.
authors: Andhira
authors: A
authors: Vieira
authors: Université de Nice-Sophia Antipolis, FR-06108 Nice, France; Inserm U1091, IBV, Diabetes Genetics Team, FR-06108 Nice, France; JDRF, 26 Broadway, NY-10004, USA.
authors: Anja
authors: A
authors: Pfeifer
authors: Université de Nice-Sophia Antipolis, FR-06108 Nice, France; Inserm U1091, IBV, Diabetes Genetics Team, FR-06108 Nice, France; JDRF, 26 Broadway, NY-10004, USA.
authors: Noémie
authors: N
authors: Druelle
authors: Université de Nice-Sophia Antipolis, FR-06108 Nice, France; Inserm U1091, IBV, Diabetes Genetics Team, FR-06108 Nice, France; JDRF, 26 Broadway, NY-10004, USA.
authors: Elisabet
authors: E
authors: Gjernes
authors: Université de Nice-Sophia Antipolis, FR-06108 Nice, France; Inserm U1091, IBV, Diabetes Genetics Team, FR-06108 Nice, France; JDRF, 26 Broadway, NY-10004, USA.
authors: Biljana
authors: B
authors: Faurite
authors: Université de Nice-Sophia Antipolis, FR-06108 Nice, France; Inserm U1091, IBV, Diabetes Genetics Team, FR-06108 Nice, France; JDRF, 26 Broadway, NY-10004, USA.
authors: Fabio
authors: F
authors: Avolio
authors: Université de Nice-Sophia Antipolis, FR-06108 Nice, France; Inserm U1091, IBV, Diabetes Genetics Team, FR-06108 Nice, France; JDRF, 26 Broadway, NY-10004, USA. Electronic address: collombat@unice.fr.
authors: Patrick
authors: P
authors: Collombat
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology*; D007515:Islets of Langerhans / Q000166:cytology* / Q000502:physiology; D051379:Mice; D012038:Regeneration / Q000502:physiology*