title: The neutrophil in antineutrophil cytoplasmic autoantibody-associated vasculitis.
abstract: Necrotizing, small-vessel vasculitis develops in patients with circulating ANCAs. Neutrophils and monocytes harbor the two major ANCA antigens, PR3 and MPO. A whole body of in vitro experiments implicated ANCA-activated neutrophil effector functions in the pathogenesis of vasculitis, whereas the role of monocytes is less well-characterized. Mouse models for anti-MPO-induced vasculitis were developed to study ANCA-neutrophil interactions in complex in vivo situations. We not only discuss the significance of ANCA-neutrophil interactions for disease induction but also how a detailed understanding of these interactions helps to identify novel treatment targets for ANCA vasculitis.
authors: 1.Virchow Klinikum Campus and Experimental and Clinical Research Center, Max-Delbrück Center for Molecular Medicine and the Charité Medical Faculty, Lindenberger Weg 80, 13125 Berlin, Germany. kettritz@charite.de.
authors: Adrian
authors: A
authors: Schreiber
authors: Ralph
authors: R
authors: Kettritz
mesh_terms: D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D004195:Disease Models, Animal; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D018375:Neutrophil Activation; D009504:Neutrophils / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology* / Q000473:pathology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic
keywords: ANCA; animal model; crescentic glomerulonephritis; inflammation