title: Extracting respiratory signals from thoracic cone beam CT projections.
abstract: The patient respiratory signal associated with the cone beam CT (CBCT) projections is important for lung cancer radiotherapy. In contrast to monitoring an external surrogate of respiration, such a signal can be extracted directly from the CBCT projections. In this paper, we propose a novel local principal component analysis (LPCA) method to extract the respiratory signal by distinguishing the respiration motion-induced content change from the gantry rotation-induced content change in the CBCT projections. The LPCA method is evaluated by comparing with three state-of-the-art projection-based methods, namely the Amsterdam Shroud method, the intensity analysis method and the Fourier-transform-based phase analysis method. The clinical CBCT projection data of eight patients, acquired under various clinical scenarios, were used to investigate the performance of each method. We found that the proposed LPCA method has demonstrated the best overall performance for cases tested and thus is a promising technique for extracting a respiratory signal. We also identified the applicability of each existing method.
authors: Center for Advanced Radiotherapy Technologies and Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92037-0843, USA.
authors: Hao
authors: H
authors: Yan
authors: Xiaoyu
authors: X
authors: Wang
authors: Wotao
authors: W
authors: Yin
authors: Tinsu
authors: T
authors: Pan
authors: Moiz
authors: M
authors: Ahmad
authors: Xuanqin
authors: X
authors: Mou
authors: Laura
authors: L
authors: Cerviño
authors: Xun
authors: X
authors: Jia
authors: Steve B
authors: SB
authors: Jiang
mesh_terms: D054893:Cone-Beam Computed Tomography / Q000379:methods*; D056973:Four-Dimensional Computed Tomography; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D009068:Movement; D025341:Principal Component Analysis; D013902:Radiography, Thoracic / Q000379:methods*; D012119:Respiration; D012399:Rotation; D013997:Time Factors
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