title: Effect of αlipoic acid and silymarin on bladder outlet obstruction.
abstract: The aim of the present study was to determine whether the treatment of obstructed rat bladders with αlipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction (BOO). A total of 32 adult Sprague Dawley rats were divided into four groups (n=8 per group): sham (placebo surgery) animals with no treatment (group 1); control animals with surgically induced BOO (group 2); obstructed rats treated with ALA (group 3); and obstructed rats treated with silymarin (group 4). Histological evaluation, bladder weights, collagen structure, TdT-mediated biotin nick end-labeling (TUNEL), inducible nitric oxide sentase (iNOS) mRNA levels, malondialdehyde (MDA) levels and tumor necrosis factor (TNF) levels were investigated. The ALA-treated group had similar bladder weights, collagen levels and TUNEL positivity and decreased iNOS levels compared with the control group, while the silymarin group exhibited further differences. Serum MDA and TNF-α levels were both decreased in the ALA and silymarin groups. ALA treatment reduced the increased oxidative stress and bladder inflammation caused by BOO and may contribute to the protection of bladder function.
authors: Department of Urology, Faculty of Medicine, Osmangazi University; Eskişehir,  Turkey.
authors: Abidin
authors: A
authors: Yildirim
authors: Barbaros
authors: B
authors: Başeskioğlu
authors: Halide E
authors: HE
authors: Temel
authors: Nilüfer
authors: N
authors: Erkasap
authors: Aydin
authors: A
authors: Yenilmez
authors: Sema
authors: S
authors: Uslu
authors: Caner
authors: C
authors: Ozer
authors: Mete
authors: M
authors: Ozkurt
authors: Turgut
authors: T
authors: Dönmez
keywords: bladder outlet obstruction; rat; silymarin; urinary bladder; αlipoic acid
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