title: Spreading of AbaR-type genomic islands in multidrug resistance Acinetobacter baumannii strains belonging to different clonal complexes.
abstract: In order to determine the occurrence of AbaR-type genomic island in multidrug resistant Acinetobacter baumannii (MDRAb) strains circulating in Argentina, Uruguay, and Chile, we studied 51 MDRAb isolates recovered from several hospitals over 30 years. AbaR-type genomic resistance islands were found in 36 MDRAb isolates since 1986 till now. MLST technique allowed us to identify the presence of four different Clonal Complexes (109, 104, 119, 113) among the positive AbaR-type island positive strains. This is the first description of AbaR-type islands in the CC104 and CC113 that are the most widespread Clonal Complexes in Argentina. In addition, PCR mapping exposed different arrays to those previously described, evidencing the plasticity of this island. Our results evidence a widespread distribution of the AbaR-type genomic islands along the time in the MDRAb population, including the epidemic global clone 1 (GC1) as well as different clonal complexes to those already described in the literature.
authors: Laboratorio de Investigaciones en Mecanismos de Resistencia a Antibióticos, Instituto de Microbiología y Parasitología Médica IMPaM, UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 Piso 12, 1121, Buenos Aires, Argentina. ramirez.mariasoledad@gmail.com
authors: María Soledad
authors: MS
authors: Ramírez
authors: Elisabet
authors: E
authors: Vilacoba
authors: María Silvina
authors: MS
authors: Stietz
authors: Andrea Karina
authors: AK
authors: Merkier
authors: Paola
authors: P
authors: Jeric
authors: Adriana S
authors: AS
authors: Limansky
authors: Carolina
authors: C
authors: Márquez
authors: Helia
authors: H
authors: Bello
authors: Mariana
authors: M
authors: Catalano
authors: Daniela
authors: D
authors: Centrón
mesh_terms: D040981:Acinetobacter baumannii / Q000145:classification* / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001118:Argentina; D002677:Chile; D016000:Cluster Analysis; D003428:Cross Infection / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D022761:Gene Transfer, Horizontal; D044404:Genomic Islands; D005838:Genotype; D006761:Hospitals; D006801:Humans; D058885:Multilocus Sequence Typing; D014583:Uruguay
chemical_list: D000900:Anti-Bacterial Agents
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