title: Presence of diastolic dysfunction in patients with peripheral artery disease.
abstract: Peripheral artery disease (PAD) and heart failure (HF) share many risk factors; however, the prevalence and characteristics of HF in patients with PAD have not been fully examined. We investigated 120 consecutive patients with PAD, defined by an ankle-brachial index ≤ 0.9. In all, 36 (30%) patients had brain natriuretic peptide (BNP) levels ≥ 100 pg/mL (high BNP group), and 84 (70%) patients had BNP levels < 100 pg/mL (low BNP group). Univariate analysis showed that high BNP was associated with age, estimated glomerular filtration rate, hypertension, and transmitral E-wave/early diastolic mitral annular velocity (E/e') ratio. Multivariate logistic regression analysis established that a high BNP was strongly and independently associated with the highest quartile of E/e', highlighting these patients' diastolic dysfunction. The prevalence of high BNP levels in patients with PAD suggests that routine BNP measurements might be useful to detect HF.
authors: Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors: Saeko
authors: S
authors: Yamasaki
authors: Atsushi
authors: A
authors: Izawa
authors: Yuji
authors: Y
authors: Shiba
authors: Takeshi
authors: T
authors: Tomita
authors: Yusuke
authors: Y
authors: Miyashita
authors: Jun
authors: J
authors: Koyama
authors: Uichi
authors: U
authors: Ikeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D003971:Diastole; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D058729:Peripheral Arterial Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D020097:Natriuretic Peptide, Brain
keywords: ankle-brachial index; brain natriuretic peptide; diastolic heart failure; peripheral artery disease