title: Minimum dose of hCG to trigger final oocyte maturation and prevent OHSS in a long GnRHa protocol.
abstract: This paper was aimed to study the minimum dose of human chorionic gonadotropin (hCG) to effectively trigger maturation of oocytes and prevent ovarian hyperstimulation syndrome (OHSS) in a series of hyper-responders treated with a long gonadotropin releasing hormone agonist (GnRHa) protocol. Six women at high risk of developing severe OHSS in a long GnRHa protocol were enrolled into this study. Serum hormone levels on the day of and after hCG administration, antral follicle count, oocyte retrieval number and quality were determined. In total, 6 women aged between 29 and 36 years and at risk of developing severe OHSS, received 2000 U hCG. Five of them were treated with coasting for 1 day and the rest one for 4 days. The mean number of oocytes collected was 19 (range 14-27) and the fertilization rate per collected oocyte was 72.81%. Of the 6 women in the study, only one cancelled embryos transfer and all embryos were frozen, and then she delivered two health boys on term in the subsequent frozen-thawed embryo transfer (FET) cycle. Pregnancies and births were achieved in 3 patients out of 5 in vitro fertilization-embryo transfer (IVF-ET) cycles. No woman developed moderate or severe OHSS. Triggering with 2000 U hCG is feasible to prevent OHSS in unpredicted hyper-responders undergoing IVF in a long GnRHa protocol.
authors: Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors: Xin
authors: X
authors: Chen
authors: Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. chensl_92@yahoo.com.
authors: Shi-Ling
authors: SL
authors: Chen
authors: Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors: Yu-Xia
authors: YX
authors: He
authors: Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors: De-Sheng
authors: DS
authors: Ye
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D009865:Oocytes / Q000187:drug effects / Q000473:pathology; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology* / Q000517:prevention & control*; D010062:Ovulation Induction / Q000009:adverse effects* / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone
references: Hum Reprod. 2002 Feb;17(2):310-3
references: 11821269
references: Fertil Steril. 1990 Mar;53(3):502-9
references: 2106456
references: Fertil Steril. 2003 May;79(5):1051-9
references: 12738494
references: Fertil Steril. 2011 Jun 30;95(8):2742-4.e1
references: 21411081
references: Fertil Steril. 1987 Dec;48(6):958-63
references: 3119376
references: Reprod Biomed Online. 2007 Jun;14(6):682-5
references: 17579978
references: Fertil Steril. 2010 Jun;94(1):189-93
references: 19376515
references: J Clin Endocrinol Metab. 2007 Jan;92(1):314-21
references: 17032719
references: Fertil Steril. 2006 Mar;85(3):547-54
references: 16500317
references: Fertil Steril. 2004 Oct;82(4):841-6
references: 15482757
references: Cochrane Database Syst Rev. 2011 Feb 16;(2):CD001302
references: 21328249
references: Fertil Steril. 2008 Dec;90(6):2172-8
references: 18439601
references: Fertil Steril. 2010 Jul;94(2):389-400
references: 20416867