title: Unique influences of adolescent antecedents on adult borderline personality disorder features.
abstract: There is a dearth of prospective information regarding adolescent precursors of borderline personality disorder (BPD). This study aimed to determine the unique associations between early maladaptive family functioning, parental psychiatric diagnoses, proband early onset psychiatric diagnosis, and BPD symptoms in adulthood using an existing longitudinal study. Participants were randomly selected from 9 high schools in western Oregon. A total of 1,709 students (ages 14-18 years) completed 2 assessments during adolescence. All adolescents with a history of a depressive disorder (n = 360) or a history of nonmood disorders (n = 284) and a random sample of adolescents with no history of psychopathology (n = 457) were invited to participate in a 3rd and 4th evaluation when participants were on average 24 years old and 30 years old, respectively. Biological parents were interviewed at the 3rd assessment. The multivariate model with all early risk factors found that maternal-child discord (p < .05), maternal BPD (p < .05), paternal substance use disorder (SUD; p < .05), and proband depression (p < .05), SUD (p < .001), and suicidality (p < .05) were associated with later BPD symptoms. Maternal SUD and proband anxiety, conduct disorder/oppositional defiant disorder, and attention-deficit/hyperactivity disorder were also associated with proband BPD symptoms in univariate analyses, but were no longer significant when the other risk factors were included in the model. Multivariate assessment models are needed to identify unique risk factors for BPD. This will enhance the efficiency of screening efforts for early detection of risk.
authors: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. steppsd@upmc.edu
authors: Stephanie D
authors: SD
authors: Stepp
authors: Thomas M
authors: TM
authors: Olino
authors: Daniel N
authors: DN
authors: Klein
authors: John R
authors: JR
authors: Seeley
authors: Peter M
authors: PM
authors: Lewinsohn
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001883:Borderline Personality Disorder / Q000453:epidemiology* / Q000523:psychology; D002648:Child; D016241:Child of Impaired Parents; D002675:Child, Preschool; D006801:Humans; D007406:Interview, Psychological; D008137:Longitudinal Studies; D001523:Mental Disorders / Q000453:epidemiology*; D009034:Mother-Child Relations / Q000523:psychology*; D015999:Multivariate Analysis; D009922:Oregon / Q000453:epidemiology; D010290:Parents / Q000523:psychology*; D016012:Poisson Distribution; D012307:Risk Factors; D057566:Self Report; D059020:Suicidal Ideation; D055815:Young Adult
references: Arch Gen Psychiatry. 1987 Jun;44(6):540-8
references: 3579500
references: Harv Rev Psychiatry. 1997 Jan-Feb;4(5):272-8
references: 9385003
references: Am J Psychiatry. 1997 Aug;154(8):1101-6
references: 9247396
references: J Am Acad Child Adolesc Psychiatry. 2006 Aug;45(8):965-972
references: 16865039
references: Psychol Bull. 2009 May;135(3):495-510
references: 19379027
references: Psychol Med. 2008 Mar;38(3):353-63
references: 17803836
references: J Pers Disord. 2006 Feb;20(1):9-15
references: 16563075
references: J Pers Disord. 2005 Oct;19(5):466-86
references: 16274277
references: Am J Psychiatry. 1997 Nov;154(11):1593-8
references: 9356570
references: Bull Menninger Clin. 2003 Summer;67(3):187-211
references: 14621062
references: Arch Gen Psychiatry. 1982 Aug;39(8):879-83
references: 7103676
references: Arch Gen Psychiatry. 2006 May;63(5):579-87
references: 16651515
references: Dev Psychopathol. 2005 Fall;17(4):1007-30
references: 16613428
references: J Am Acad Child Adolesc Psychiatry. 1997 Dec;36(12):1752-9
references: 9401337
references: J Am Acad Child Psychiatry. 1982 Jul;21(4):392-7
references: 7119313
references: J Appl Behav Anal. 1979 Winter;12(4):691-700
references: 541311
references: Addict Behav. 2005 Oct;30(9):1709-24
references: 16095845
references: Arch Gen Psychiatry. 1994 Mar;51(3):215-24
references: 8122958
references: J Am Acad Child Adolesc Psychiatry. 2001 Jan;40(1):83-90
references: 11195569
references: J Pers Disord. 2000 Fall;14(3):208-17
references: 11019745
references: J Abnorm Psychol. 2003 Aug;112(3):353-63
references: 12943014
references: Arch Gen Psychiatry. 2001 Mar;58(3):231-6
references: 11231829
references: Arch Gen Psychiatry. 2011 Jul;68(7):753-62
references: 21727257
references: J Pers Disord. 2000 Fall;14(3):264-73
references: 11019749
references: J Abnorm Psychol. 1993 Feb;102(1):133-44
references: 8436689
references: Compr Psychiatry. 2007 Jan-Feb;48(1):70-8
references: 17145285
references: Am J Psychiatry. 1999 Oct;156(10):1529-35
references: 10518162
references: J Child Psychol Psychiatry. 2010 Feb;51(2):188-98
references: 19703095
references: Am J Psychiatry. 1991 Oct;148(10):1378-85
references: 1897620
references: J Consult Clin Psychol. 1993 Dec;61(6):1068-75
references: 8113485
references: J Abnorm Psychol. 1999 Aug;108(3):490-9
references: 10466273
references: Arch Gen Psychiatry. 1991 Aug;48(8):720-8
references: 1883255
references: J Abnorm Child Psychol. 2002 Oct;30(5):463-75
references: 12403150
references: Child Dev. 1965 Jun;36:413-24
references: 14300862
references: Dev Psychopathol. 2004 Winter;16(1):193-213
references: 15115071
references: Arch Gen Psychiatry. 2001 May;58(5):453-60
references: 11343524
references: Harv Rev Psychiatry. 2003 Jan-Feb;11(1):8-19
references: 12866737
references: J Abnorm Child Psychol. 2012 Jan;40(1):35-44
references: 21853377