title: Early detection of acute mesenteric ischemia using diffusion-weighted 3.0-T magnetic resonance imaging in a porcine model.
abstract: OBJECTIVE
  The aim of this study was to investigate if 3.0-T diffusion-weighted magnetic resonance imaging (MRI) can be used for early detection of acute occlusive and nonocclusive mesenteric ischemia.
  
  
  METHODS
  In this study, approved by the official committee on animal affairs, proximal (occlusive) mesenteric ischemia and peripheral (nonocclusive) mesenteric ischemia were induced in 8 and 2, respectively, female domestic pigs. Proximal mesenteric ischemia was induced by intra-arterial injection of n-butyl-cyanoacrylate in the superior mesenteric artery or 1 of its main branches; peripheral mesenteric ischemia was induced by intra-arterial injection of microparticles. Before embolization and at 30-, 60-, and 90-minute intervals after embolization, diffusion-weighted imaging was performed, and apparent diffusion coefficient (ADC) maps were calculated on a clinical 3.0-T system. Immediately after the last MRI session, animals were killed to provide a pathological correlation for mesenteric ischemia.
  
  
  RESULTS
  Ischemic bowel parts appeared hyperintense on diffusion-weighted images and hypointense on the corresponding ADC maps. Mean diffusion-weighted imaging signal intensity increased and ADC decreased significantly within 30 minutes after embolization (P < 0.001) and remained unchanged until 90 minutes after injury, independent of the embolization method.
  
  
  CONCLUSIONS
  3.0-Tesla diffusion-weighted MRI may help detect acute mesenteric ischemia as early as 30 minutes after vessel occlusion.
authors: Department of Diagnostic and Interventional Radiology, University Hospital, RWTH Aachen University, Aachen, Germany. rbruhn@ukaachen.de
authors: Robin Sebastian
authors: RS
authors: Bruhn
authors: Martina Susanne
authors: MS
authors: Distelmaier
authors: Miriam
authors: M
authors: Hellmann-Sokolis
authors: Amjad
authors: A
authors: Naami
authors: Christiane Katharina
authors: CK
authors: Kuhl
authors: Christian
authors: C
authors: Hohl
mesh_terms: D000818:Animals; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004621:Embolization, Therapeutic; D005260:Female; D007511:Ischemia / Q000175:diagnosis* / Q000628:therapy; D065666:Mesenteric Ischemia; D011446:Prospective Studies; D013552:Swine; D014652:Vascular Diseases / Q000175:diagnosis* / Q000628:therapy