title: Adhesins in human fungal pathogens: glue with plenty of stick.
abstract: Understanding the pathogenesis of an infectious disease is critical for developing new methods to prevent infection and diagnose or cure disease. Adherence of microorganisms to host tissue is a prerequisite for tissue invasion and infection. Fungal cell wall adhesins involved in adherence to host tissue or abiotic medical devices are critical for colonization leading to invasion and damage of host tissue. Here, with a main focus on pathogenic Candida species, we summarize recent progress made in the field of adhesins in human fungal pathogens and underscore the importance of these proteins in establishment of fungal diseases.
authors: Regional Center for Biomedical Research, Albacete Science and Technology Park, University of Castilla-La Mancha, Albacete, Spain.
authors: Piet W J
authors: PW
authors: de Groot
authors: Oliver
authors: O
authors: Bader
authors: Albert D
authors: AD
authors: de Boer
authors: Michael
authors: M
authors: Weig
authors: Neeraj
authors: N
authors: Chauhan
mesh_terms: D000595:Amino Acid Sequence; D002175:Candida / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D002177:Candidiasis / Q000382:microbiology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism; D002473:Cell Wall / Q000235:genetics / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D054884:Host-Pathogen Interactions; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D005810:Multigene Family; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
chemical_list: C109455:ALA1 protein, Candida albicans; D015815:Cell Adhesion Molecules; D005656:Fungal Proteins; C118102:HWP1 protein, Candida albicans; D008562:Membrane Glycoproteins
references: PLoS Pathog. 2006 Jul;2(7):e63
references: 16839200
references: Microbiol Res. 2011 Jul 20;166(5):430-6
references: 20869222
references: Eukaryot Cell. 2011 Oct;10(10):1317-30
references: 21841123
references: Microbiology (Reading). 2008 Apr;154(Pt 4):1193-1203
references: 18375812
references: Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22511-6
references: 21149680
references: Mol Microbiol. 2005 Feb;55(4):1259-71
references: 15686569
references: Genetics. 2012 Nov;192(3):775-818
references: 23135325
references: Eukaryot Cell. 2011 Aug;10(8):1071-81
references: 21622905
references: Infect Immun. 2002 Jul;70(7):3443-56
references: 12065484
references: Nature. 2009 Aug 27;460(7259):1117-21
references: 19713928
references: Science. 1999 Mar 5;283(5407):1535-8
references: 10066176
references: Eukaryot Cell. 2010 Mar;9(3):393-404
references: 20038605
references: Mycopathologia. 2009 Aug;168(2):73-7
references: 19347602
references: Yeast. 2004 Mar;21(4):285-302
references: 15042589
references: Med Mycol. 2008 Feb;46(1):1-15
references: 17852717
references: Eukaryot Cell. 2004 Apr;3(2):536-45
references: 15075282
references: PLoS One. 2011;6(10):e25909
references: 22028796
references: Annu Rev Microbiol. 2001;55:625-46
references: 11544369
references: Mol Microbiol. 2003 Apr;48(1):53-65
references: 12657044
references: FEMS Yeast Res. 2012 Jun;12(4):398-414
references: 22225518
references: J Oral Pathol Med. 2007 Sep;36(8):456-67
references: 17686003
references: PLoS Pathog. 2012;8(6):e1002765
references: 22737071
references: Eukaryot Cell. 2010 Sep;9(9):1403-15
references: 20656913
references: PLoS Biol. 2007 Mar;5(3):e64
references: 17311474
references: Infect Immun. 2004 Apr;72(4):2029-34
references: 15039323
references: Annu Rev Genet. 2009;43:1-24
references: 19640229
references: Fungal Genet Biol. 2012 Feb;49(2):173-9
references: 22230096
references: Microbiology (Reading). 2005 May;151(Pt 5):1619-1630
references: 15870470
references: Eukaryot Cell. 2008 Mar;7(3):483-92
references: 18178776
references: FEMS Yeast Res. 2006 Nov;6(7):979-86
references: 17042747
references: PLoS Pathog. 2012 Feb;8(2):e1002525
references: 22359502
references: Eukaryot Cell. 2006 Oct;5(10):1664-73
references: 16936142
references: PLoS Pathog. 2008 Nov;4(11):e1000217
references: 19023418
references: Biotechnol Lett. 2010 Nov;32(11):1571-85
references: 20640875
references: Mol Microbiol. 2002 Oct;46(2):479-92
references: 12406223
references: Microbiology (Reading). 2005 May;151(Pt 5):1631-1644
references: 15870471
references: Infect Immun. 1997 Dec;65(12):5289-94
references: 9393828
references: J Antimicrob Chemother. 2007 Aug;60(2):424-8
references: 17562683
references: Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16864-9
references: 23035251
references: Fungal Genet Biol. 2012 Apr;49(4):322-31
references: 22343036
references: Clin Microbiol Rev. 2007 Jan;20(1):133-63
references: 17223626
references: J Biol Chem. 2006 Jan 13;281(2):688-94
references: 16269404
references: Curr Opin Microbiol. 2005 Aug;8(4):378-84
references: 15996895
references: Microbiol Mol Biol Rev. 2006 Jun;70(2):317-43
references: 16760306
references: Trends Microbiol. 2001 Jul;9(7):327-35
references: 11435107
references: Infect Immun. 1998 Apr;66(4):1783-6
references: 9529114
references: Genome Res. 2003 Sep;13(9):2005-17
references: 12952872
references: Appl Microbiol Biotechnol. 2007 Jan;73(6):1363-76
references: 17024473
references: PLoS One. 2011 Mar 08;6(3):e17632
references: 21408122
references: J Med Microbiol. 2009 Jun;58(Pt 6):714-722
references: 19429746
references: Eukaryot Cell. 2011 Jan;10(1):98-109
references: 21097664
references: Eukaryot Cell. 2010 Mar;9(3):405-14
references: 19820118
references: Eukaryot Cell. 2007 Feb;6(2):119-33
references: 17189485
references: Microbiology (Reading). 2004 Jul;150(Pt 7):2415-2428
references: 15256583
references: Cell Microbiol. 2010 Mar;12(3):273-82
references: 19919567
references: Microbiology (Reading). 2005 Mar;151(Pt 3):673-681
references: 15758214
references: Science. 1999 Jul 23;285(5427):578-82
references: 10417386
references: ACS Nano. 2012 Sep 25;6(9):7703-11
references: 22924880
references: PLoS Pathog. 2009 Oct;5(10):e1000601
references: 19798425
references: Genome Res. 2009 Dec;19(12):2231-44
references: 19745113
references: Eukaryot Cell. 2012 Jun;11(6):795-805
references: 22505336
references: Eukaryot Cell. 2008 Nov;7(11):1951-64
references: 18806209
references: Eukaryot Cell. 2008 May;7(5):776-82
references: 18083824
references: J Infect Dis. 2010 Jun 1;201(11):1718-28
references: 20415594
references: Proteomics. 2009 Oct;9(20):4755-69
references: 19688728
references: PLoS One. 2012;7(4):e35750
references: 22563396
references: Cell Mol Life Sci. 2010 Mar;67(5):671-6
references: 19946728
references: Infect Immun. 1994 Oct;62(10):4380-8
references: 7927699
references: Microbiology (Reading). 2004 Oct;150(Pt 10):3129-44
references: 15470094
references: Mol Microbiol. 2011 Jun;80(6):1667-79
references: 21585565
references: Eukaryot Cell. 2004 Jun;3(3):776-84
references: 15189998
references: Curr Opin Infect Dis. 2010 Dec;23(6):560-6
references: 20717027
references: J Bacteriol. 1998 Dec;180(24):6503-10
references: 9851992
references: Eukaryot Cell. 2010 Oct;9(10):1622-34
references: 20709785
references: Microbiology (Reading). 2012 Dec;158(Pt 12):2975-2986
references: 22918893
references: J Dent Res. 2010 Jul;89(7):657-65
references: 20448246
references: Mol Microbiol. 2006 Apr;60(1):5-15
references: 16556216
references: Science. 2005 May 6;308(5723):866-70
references: 15774723
references: Acta Crystallogr D Biol Crystallogr. 2012 Mar;68(Pt 3):210-7
references: 22349222
references: J Biol Chem. 2004 Sep 24;279(39):40737-47
references: 15262971
references: Mol Microbiol. 2007 Oct;66(2):279-90
references: 17854405
references: Mycopathologia. 2011 Dec;172(6):415-27
references: 21769633
references: Mol Microbiol. 2003 Jan;47(1):89-102
references: 12492856
references: Trends Microbiol. 2012 Feb;20(2):59-65
references: 22099004
references: Med Mycol. 2007 Jun;45(4):321-46
references: 17510856
references: Biochem J. 2004 Sep 15;382(Pt 3):769-81
references: 15214846
references: Infect Immun. 2006 May;74(5):3039-41
references: 16622247
references: J Bacteriol. 1996 Sep;178(18):5353-60
references: 8808922
references: Cell Microbiol. 2002 Aug;4(8):461-9
references: 12174081
references: Microbiology (Reading). 2009 Jun;155(Pt 6):2004-2020
references: 19383685
references: Curr Biol. 2008 Jul 22;18(14):1017-24
references: 18635358
references: Nature. 2009 Jun 4;459(7247):657-62
references: 19465905
references: Mol Microbiol. 2005 Feb;55(4):1246-58
references: 15686568
references: J Immunol. 2001 Feb 15;166(4):2665-73
references: 11160330
references: PLoS One. 2012;7(3):e33362
references: 22428031
references: Infect Immun. 2010 Nov;78(11):4644-52
references: 20805332
references: Eukaryot Cell. 2009 Mar;8(3):373-87
references: 19151328
references: Eukaryot Cell. 2011 Feb;10(2):168-73
references: 21115738
references: BMC Microbiol. 2008 Jul 14;8:116
references: 18625069
references: Trends Microbiol. 2001 Apr;9(4):176-80
references: 11286882
references: Eukaryot Cell. 2003 Dec;2(6):1266-73
references: 14665461
references: Eukaryot Cell. 2007 Jun;6(6):931-9
references: 17416898
references: Eukaryot Cell. 2009 Dec;8(12):1909-13
references: 19837954
references: Infect Immun. 1999 Nov;67(11):6040-7
references: 10531265
references: Colloids Surf B Biointerfaces. 2007 Aug 1;58(2):250-5
references: 17481864
references: Genes Dev. 2003 Sep 15;17(18):2245-58
references: 12952896
references: J Infect Dis. 2001 Nov 1;184(9):1170-5
references: 11598840
references: Mol Microbiol. 2008 May;68(3):547-59
references: 18394144
references: Med Mycol. 2007 Aug;45(5):429-34
references: 17654269
references: J Biol Chem. 2004 Jul 16;279(29):30480-9
references: 15128742
references: Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20744-9
references: 21059927
references: Microbiol Res. 2010 Mar 31;165(3):250-8
references: 19616419
references: Nat Biotechnol. 2004 Oct;22(10):1302-6
references: 15361882
references: Genetics. 2000 Sep;156(1):31-44
references: 10978273
references: ACS Nano. 2012 Dec 21;6(12):10950-64
references: 23145462
references: Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15775-9
references: 21896717
references: FEMS Immunol Med Microbiol. 2012 Jun;65(1):121-4
references: 22321066
references: Med Mycol. 2001;39 Suppl 1:1-8
references: 11800263
references: FEMS Yeast Res. 2011 Nov;11(7):595-601
references: 21726406
references: Infect Immun. 2007 Jun;75(6):2922-8
references: 17371861
references: Glycobiology. 1999 Nov;9(11):1281-6
references: 10536044
references: BMC Genomics. 2011 Apr 15;12:192
references: 21496229