title: [Synergistic exposure to noise and styrene and cochlear functionality in a sample of exposed workers: preliminary results].
abstract: This study is aimed at testing the cochlear functionality using otoacoustic emissions, analyzing the synergistic effects of simultaneous exposure to noise and organic solvents EBTx on workers of a glass-reinforced plastic products factory. Exposure to organic solvents was assessed using ambiental measurements and evaluation of the salivary concentration. Biological monitoring was performed evaluating the urinary concentration of the styrene metabolites. Statistical analysis shows that otoacoustic tests can discriminate between different exposure groups. Significant differences were found between controls and subjects exposed to high styrene and low noise levels, showing the ototoxic effect (at sub-clinical level) of the styrene exposure.
authors: INAIL ex-ISPESL, Dipartimento Igiene del Lavoro, Monteporzio Catone, Roma, Italy. renata.sisto@ispesl.it
authors: R
authors: R
authors: Sisto
authors: L
authors: L
authors: Cerini
authors: P
authors: P
authors: Garofani
authors: M P
authors: MP
authors: Gatto
authors: M
authors: M
authors: Gherardi
authors: A
authors: A
authors: Gordiani
authors: E
authors: E
authors: Paci
authors: E
authors: E
authors: Sanjust
authors: B
authors: B
authors: Papaleo
authors: G
authors: G
authors: Tranfo
mesh_terms: D000328:Adult; D003051:Cochlea / Q000187:drug effects* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009623:Noise, Occupational / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D020058:Styrene / Q000009:adverse effects*
chemical_list: D020058:Styrene