title: [Follow-up examination for high risk infants with auditory neuropathy spectrum disorder].
abstract: OBJECTIVE
  The goal was to know more about the characteristic of auditory neuropathy spectrum disorder (ANSD) for high risk infants.
  
  
  METHODS
  The newborn hearing screening was performed with automatic auditory brainstem response (AABR) and transient evoked otoacoustic emission(TEOAE) for the infants in the NICUs from August 2007 to January 2011. After subsequent rescreening, children with AABR test referred were perform hearing test set including high frequency (1000 Hz) tympanometry, ABR, DPOAE and/or Cochlear Microphonics (CMs) in 3 months old. Only infants demonstrated severely abnormal ABRs along with preserved DPOAEs and/or CMs were scheduled for re-examination in 6-8 months old and Behavior audiometry in 8-12 months old.
  
  
  RESULTS
  Eighteen infants (14 cases were bilateral and 4 cases were unilateral) considered as suffering from AN in 3 months old. All of them showed ABR thresholds > or = 80 dB nHL or absent at maximum test intensity. Follow-up examination revealed 9 cases (18 ears) with restoration of ABR to normal or a lower ABR thresholds and a resolution of ANSI) in 11 out of 18 infants retested in 6-8 months old. CMs were present in all ears but DPOAE were not present in 4 ears with middle ear pathology in 3 months test. Behavioral hearing of 10 cases ranged from mild (n = 2), moderate(n = 4) to severe and profound loss (n = 4).
  
  
  CONCLUSIONS
  ANSD in high risk neonates could show the temporary character. It was too difficult to forecast the prognosis, they would be to follow up to at least 3 years old for newborn ANSD.
authors: Department of Otorhinolaryngology, Wuhan Children's Hospital, Wuhan, 430012, China. w82828114@163.com
authors: Youhua
authors: Y
authors: Wei
authors: Zhinan
authors: Z
authors: Wang
authors: Zhongqiang
authors: Z
authors: Xu
authors: Ping
authors: P
authors: Chen
authors: Jun
authors: J
authors: Li
mesh_terms: D002675:Child, Preschool; D016057:Evoked Potentials, Auditory, Brain Stem; D005500:Follow-Up Studies; D006313:Hearing Loss, Central / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D000160:Vestibulocochlear Nerve Diseases / Q000175:diagnosis / Q000503:physiopathology