title: Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites.
abstract: Malaria is a disease that has a major impact in many developing nations, especially on the African continent. There is a need to develop new therapeutics and prophylactic treatments against it. A trisubstituted pyrrole was recently found to inhibit infection of mammalian hepatocytes by Plasmodium sporozoites, but the target of this agent is not known. In this study trisubstituted pyrrole derivatives with different substituents on a piperidinyl nitrogen were prepared. We determined if modifications of the piperidinyl nitrogen would accommodate a drug-biotin linking strategy for affinity purification of the trisubstituted pyrrole's target protein(s).
authors: Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, 115 S. Grand Ave., S311 PHAR, Iowa City, IA 52240, USA.
authors: Tyrell
authors: T
authors: Towle
authors: Isabell
authors: I
authors: Chang
authors: Isabel
authors: I
authors: Chang
authors: Robert J
authors: RJ
authors: Kerns
authors: Purnima
authors: P
authors: Bhanot
mesh_terms: D000818:Animals; D022781:Hepatocytes / Q000469:parasitology; D009584:Nitrogen / Q000737:chemistry; D010880:Piperidines / Q000737:chemistry; D010961:Plasmodium / Q000254:growth & development / Q000378:metabolism*; D015800:Protozoan Proteins / Q000737:chemistry* / Q000378:metabolism; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D034101:Sporozoites / Q000187:drug effects / Q000378:metabolism
chemical_list: D010880:Piperidines; D015800:Protozoan Proteins; D011758:Pyrroles; C032727:piperidine; D009584:Nitrogen
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