title: Association between cerebral metabolism and Rey-Osterrieth Complex Figure Test performance in Alzheimer's disease.
abstract: The copy condition of the Rey-Osterrieth Complex Figure (ROCF) is sensitive to Alzheimer's disease (AD) pathology, but its neural correlates remain unclear. We used fluorodeoxyglucose positron emission tomography (FDG-PET) to elucidate this association in 77 patients with probable AD. We observed a correlation between ROCF and metabolic rate of bilateral temporal-parietal cortex and occipital lobe, and right frontal lobe. Global and local elements of the ROCF correlated with metabolic rate of these same regions. The copy approach correlated with right lateral temporal cortex. The ROCF appears reflective of posterior temporal-parietal cortex functioning, highlighting the role of visuospatial processing in constructional abilities in AD.
authors: Brain, Behavior & Aging Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA. rjmelrose@ucla.edu
authors: Rebecca J
authors: RJ
authors: Melrose
authors: Dylan
authors: D
authors: Harwood
authors: Theresa
authors: T
authors: Khoo
authors: Mark
authors: M
authors: Mandelkern
authors: David L
authors: DL
authors: Sultzer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001931:Brain Mapping; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011877:Radionuclide Imaging
references: J Psychiatr Res. 1975 Nov;12(3):189-98
references: 1202204
references: Int J Geriatr Psychiatry. 2002 Jul;17(7):641-8
references: 12112162
references: Dement Geriatr Cogn Disord. 2008;26(4):306-13
references: 18841015
references: J Psychiatr Res. 2010 May;44(7):462-9
references: 19875130
references: J Clin Exp Neuropsychol. 2002 Feb;24(1):1-17
references: 11935419
references: J Clin Exp Neuropsychol. 1995 Aug;17(4):566-79
references: 7593476
references: Neuropsychologia. 2002;40(8):1173-86
references: 11931921
references: J Clin Exp Neuropsychol. 2006 Aug;28(6):884-97
references: 16822730
references: Neuropsychiatry Neuropsychol Behav Neurol. 2002 Sep;15(3):198-206
references: 12218713
references: Arch Phys Med Rehabil. 2000 Jan;81(1):89-94
references: 10638882
references: Behav Neurol. 2000;12(4):191-200
references: 11568431
references: Alzheimers Dement. 2011 May;7(3):263-9
references: 21514250
references: J Geriatr Psychiatry Neurol. 2011 Mar;24(1):23-32
references: 21164171
references: Nature. 1996 Aug 15;382(6592):626-8
references: 8757132
references: J Nucl Med. 1986 Feb;27(2):235-8
references: 3712040
references: J Alzheimers Dis. 2010;19(2):517-27
references: 20110598
references: Neuropsychologia. 1989;27(9):1165-78
references: 2812299
references: Cortex. 2009 Mar;45(3):386-93
references: 19111291
references: Neuroimage. 2002 Apr;15(4):870-8
references: 11906227
references: J Neurol. 2005 Mar;252(3):283-90
references: 16189724
references: Brain Res Cogn Brain Res. 2003 May;16(3):338-47
references: 12706214
references: Clin Neurophysiol. 2005 Feb;116(2):364-75
references: 15661114
references: Neuroimage. 2002 Jan;15(1):273-89
references: 11771995
references: Brain Cogn. 2008 Jun;67(1):88-93
references: 18215449
references: Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1621-5
references: 2000370
references: Arch Clin Neuropsychol. 2003 Aug;18(6):655-72
references: 14591439
references: Neuropsychologia. 2011 Dec;49(14):3931-45
references: 22019776
references: J Clin Neuropsychol. 1982 May;4(1):51-8
references: 7096586
references: Neuropsychology. 2000 Jul;14(3):415-26
references: 10928745
references: Brain Dev. 2005 Dec;27(8):564-9
references: 16310591
references: J Clin Exp Neuropsychol. 2004 Nov;26(8):1103-12
references: 15590463
references: Neurobiol Aging. 2012 Jan;33(1):53-60
references: 20359778
references: Neurobiol Aging. 2009 Feb;30(2):186-97
references: 17651869
references: Biol Psychiatry. 1999 Apr 1;45(7):905-16
references: 10202579
references: J Int Neuropsychol Soc. 1999 Sep;5(6):502-9
references: 10561930
references: Arch Neurol. 2003 Jul;60(7):949-56
references: 12873851
references: Neurology. 1984 Jul;34(7):939-44
references: 6610841
references: Neuroimage. 2004 Oct;23(2):698-707
references: 15488419
references: Neuropsychologia. 2000;38(10):1356-61
references: 10869578
references: Eur J Neurosci. 1999 Mar;11(3):1011-36
references: 10103094
references: Psychiatry Clin Neurosci. 2002 Feb;56(1):25-9
references: 11929568
references: Alzheimer Dis Assoc Disord. 1998 Sep;12(3):163-6
references: 9772018
references: Cortex. 2009 Mar;45(3):394-406
references: 18715555
references: J Clin Exp Neuropsychol. 2000 Oct;22(5):613-21
references: 11094396
references: J Gerontol. 1991 Mar;46(2):P58-66
references: 1997577
references: J Int Neuropsychol Soc. 2006 May;12(3):383-90
references: 16903130
references: J Geriatr Psychiatry Neurol. 2011 Sep;24(3):127-34
references: 21856969
references: Neurobiol Aging. 2006 May;27(5):681-90
references: 15908048
references: Dement Geriatr Cogn Disord. 2005;19(5-6):390-6
references: 15802915
references: Behav Neurol. 2008;20(1-2):55-60
references: 19491474
references: J Int Neuropsychol Soc. 2008 Nov;14(6):1034-45
references: 18954483