title: Pregnancy following ovarian induction in a patient with premature ovarian failure and undetectable serum anti-Müllerian hormone.
abstract: We report the first case, to the best of our knowledge, of successful conception following ovarian induction in a patient with premature ovarian failure and undetectable serum anti-Müllerian hormone. A 34-year-old woman was referred because of ovarian amenorrhea. After endogenous gonadotrophins were normalized by hormone-replacement therapy and gonadotrophin-releasing hormone agonist, ovarian induction was performed using exogenous gonadotrophins. On ovarian induction day 8, one follicle had reached a mean diameter of 19.6 mm, the serum estradiol level had increased to 516 pg/mL, and human chorionic gonadotrophin (HCG) was injected. On HCG injection day 7, ultrasonography was unable to detect the follicle, and serum progesterone levels had increased to 6.1 ng/mL. One month after HCG injection, ultrasonography detected an intrauterine fetus with beating heart. Even with serum anti-Müllerian hormone levels below the threshold of detection, there is a chance for patients with premature ovarian failure.
authors: Department of Obstetrics and Gynecology, Kinki University Faculty of Medicine, Osaka, Japan. i-tsuji@med.kindai.ac.jp
authors: Isao
authors: I
authors: Tsuji
authors: Kazumi
authors: K
authors: Ami
authors: Nahoko
authors: N
authors: Fujinami
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood; D010064:Embryo Implantation; D015914:Estrogen Replacement Therapy; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D016729:Leuprolide / Q000627:therapeutic use; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D012720:Severity of Illness Index
chemical_list: D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins; D054304:Anti-Mullerian Hormone; D016729:Leuprolide