title: Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.
abstract: Olfactory receptors are G protein-coupled receptors that mediate olfactory chemosensation and serve as chemosensors in other tissues. We find that Olfr78, an olfactory receptor expressed in the kidney, responds to short chain fatty acids (SCFAs). Olfr78 is expressed in the renal juxtaglomerular apparatus, where it mediates renin secretion in response to SCFAs. In addition, both Olfr78 and G protein-coupled receptor 41 (Gpr41), another SCFA receptor, are expressed in smooth muscle cells of small resistance vessels. Propionate, a SCFA shown to induce vasodilation ex vivo, produces an acute hypotensive response in wild-type mice. This effect is differentially modulated by disruption of Olfr78 and Gpr41 expression. SCFAs are end products of fermentation by the gut microbiota and are absorbed into the circulation. Antibiotic treatment reduces the biomass of the gut microbiota and elevates blood pressure in Olfr78 knockout mice. We conclude that SCFAs produced by the gut microbiota modulate blood pressure via Olfr78 and Gpr41.
authors: Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jpluznick@jhmi.edu
authors: Jennifer L
authors: JL
authors: Pluznick
authors: Ryan J
authors: RJ
authors: Protzko
authors: Haykanush
authors: H
authors: Gevorgyan
authors: Zita
authors: Z
authors: Peterlin
authors: Arnold
authors: A
authors: Sipos
authors: Jinah
authors: J
authors: Han
authors: Isabelle
authors: I
authors: Brunet
authors: La-Xiang
authors: LX
authors: Wan
authors: Federico
authors: F
authors: Rey
authors: Tong
authors: T
authors: Wang
authors: Stuart J
authors: SJ
authors: Firestein
authors: Masashi
authors: M
authors: Yanagisawa
authors: Jeffrey I
authors: JI
authors: Gordon
authors: Anne
authors: A
authors: Eichmann
authors: Janos
authors: J
authors: Peti-Peterdi
authors: Michael J
authors: MJ
authors: Caplan
mesh_terms: D000818:Animals; D018533:Biomass; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D006973:Hypertension / Q000235:genetics / Q000378:metabolism / Q000382:microbiology; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D007668:Kidney / Q000378:metabolism*; D054892:Metagenome / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011422:Propionates / Q000378:metabolism / Q000494:pharmacology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D018035:Receptors, Odorant / Q000235:genetics / Q000378:metabolism*; D012083:Renin / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
chemical_list: C506482:Gpcr41 protein, mouse; C000603341:Olfr78 protein, mouse; D011422:Propionates; D043562:Receptors, G-Protein-Coupled; D018035:Receptors, Odorant; D012083:Renin; C029658:propionic acid
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