title: Increased serum resistin levels in patients with coronary slow-flow phenomenon.
abstract: BACKGROUND
  Slow coronary flow (SCF) is an angiographic finding characterized by delayed opacification of the epicardial coronary arteries without obstructive coronary disease. Resistin, an adipocytokine, plays a major role besides low-grade inflammation in atherosclerotic vascular processes and may be of importance in other coronary pathologies such as SCF.
  
  
  METHODS
  The present study was cross-sectional and observational, consisting of 70 individuals who underwent coronary angiography and had angiographically normal coronary arteries of varying coronary flow rates. The study included 50 patients with isolated SCF and 20 control participants with normal coronary flow (NCF).
  
  
  RESULTS
  There were no statistically significant differences between the SCF and NCF groups with respect to age, gender, presence of hypertension or diabetes mellitus, and smoking habit, except for increased creatinine levels (p = 0.014). The serum resistin level was significantly higher in the SCF group than in the NCF group (8.4 ± 7.2 vs. 5.4 ± 2.6 ng/ml, p = 0.014). Ln-transformed resistin levels correlated positively with left anterior descending (LAD) coronary artery TIMI frame count (TFC) (r = 0.408, p < 0.001) as well as with glucose (r = 0.340, p = 0.004), creatinine (r = 0.248, p = 0.044), and C-reactive protein (CRP; r = 0.283, p = 0.023) levels, and negatively with LAD coronary flow velocity (r = - 0.314, p = 0.009). When multivariate analyses were performed, in linear regression analysis, ln-resistin was associated with a longer TFC [beta (standardized regression coefficient): 0.404, p = 0.001] and lower coronary flow velocity (beta: - 0.280, p = 0.035); in logistic regression analysis, ln-resistin was an independent predictor of the presence of SCF (OR: 6.692, 65 %CI: 1.117-40.1, p = 0.037).
  
  
  CONCLUSIONS
  We demonstrated, for the first time, a significant increase in serum resistin levels in patients with SCF compared to subjects with NCF. We believe that further studies are needed to clarify the role of resistin in patients with SCF.
authors: Department of Cardiology, Rize Education and Research Hospital, 53020, Rize, Turkey.
authors: A
authors: A
authors: Canga
authors: M
authors: M
authors: Cetin
authors: S A
authors: SA
authors: Kocaman
authors: M E
authors: ME
authors: Durakoğlugil
authors: A
authors: A
authors: Kırbaş
authors: T
authors: T
authors: Erdoğan
authors: A
authors: A
authors: Temiz
authors: A
authors: A
authors: Yılmaz
authors: Y
authors: Y
authors: Ciçek
mesh_terms: D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054318:No-Reflow Phenomenon / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D015203:Reproducibility of Results; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014421:Turkey / Q000453:epidemiology; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D052243:Resistin
references: Eur Heart J. 2001 Oct;22(20):1924-30
references: 11601836
references: Am J Cardiol. 2001 Mar 15;87(6):777-9, A8
references: 11249903
references: Jpn Heart J. 2003 Nov;44(6):907-19
references: 14711186
references: Atherosclerosis. 2007 Jul;193(1):121-8
references: 16814296
references: Circ J. 2003 Dec;67(12):1022-8
references: 14639018
references: Int J Cardiol. 2004 Oct;97(1):35-41
references: 15336804
references: Circulation. 2003 Aug 12;108(6):736-40
references: 12874180
references: Circulation. 2001 Nov 13;104(20):2401-6
references: 11705815
references: Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2997-3002
references: 16905596
references: Circulation. 2005 Feb 22;111(7):932-9
references: 15710760
references: Turk Kardiyol Dern Ars. 2010 Jul;38(5):327-33
references: 21200102
references: Int J Cardiol. 2005 Jul 20;102(3):419-23
references: 16004886
references: Am Heart J. 1972 Jul;84(1):66-71
references: 5080284
references: Circulation. 1986 Nov;74(5):964-72
references: 3769180
references: Angiology. 2001 Aug;52(8):507-14
references: 11512688
references: Circulation. 1996 Mar 1;93(5):879-88
references: 8598078
references: J Clin Endocrinol Metab. 2004 Feb;89(2):765-9
references: 14764794
references: Adv Ther. 2008 Jan;25(1):37-44
references: 18264683
references: Clin Cardiol. 2005 Mar;28(3):145-8
references: 15813623
references: Int J Cardiol. 2006 Apr 4;108(2):224-30
references: 16002164
references: Coron Artery Dis. 2003 Apr;14(2):155-61
references: 12655279
references: Biochem Biophys Res Commun. 2004 Feb 6;314(2):415-9
references: 14733921
references: Endocrinology. 2003 Jun;144(6):2195-200
references: 12746274
references: Int J Cardiol. 2009 Oct 2;137(2):137-44
references: 18762343
references: Atherosclerosis. 2008 Mar;197(1):257-63
references: 17537444
references: Cathet Cardiovasc Diagn. 1996 Apr;37(4):375-81
references: 8721694
references: Med Hypotheses. 2006;66(3):504-8
references: 16288834
references: Atherosclerosis. 2005 Oct;182(2):241-8
references: 16159596
references: Circulation. 2004 Nov 23;110(21):3335-40
references: 15545519