title: Monitoring target specific anticoagulants.
abstract: New, target specific, oral anticoagulants have been shown to be safe and effective in prevention and treatment of thromboembolism without laboratory monitoring. However, clinical use of the drugs dabigatran, rivaroxaban, and apixaban requires laboratory measurement of their anticoagulant effect in specific clinical situations. This paper reviews the data available on use of screening and specialized testing to measure the anticoagulant effect and drug levels in patients prescribed these medications. Their effect on other coagulation assays is also reviewed.
authors: Puget Sound Blood Center, University of Washington School of Medicine, Seattle, WA, USA. barbarak@psbc.org
authors: Barbara A
authors: BA
authors: Konkle
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001780:Blood Coagulation Tests / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*
chemical_list: D000925:Anticoagulants
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