title: One-pot, exchange-free, room-temperature synthesis of sub-10 nm aqueous, noninteracting, and stable zwitterated iron oxide nanoparticles.
abstract: Stable aqueous dispersions of superparamagnetic iron oxide nanoparticles were synthesized in one step in the presence of a zwitterionic siloxane as the stabilizing/capping/solubilizing ligand. The hydrodynamic diameter of the particles was tuned by controlling the concentration of zwitterion siloxane, which ultimately yielded monodisperse nanoparticles small enough for renal filtration (<6 nm diameter). The zwitterated nanoparticles were readily dispersed and stable in aqueous media in the pH range 6-9 but exhibited lower magnetization values than nonzwitterated materials due to amorphous content and spin canting, typical for particles of such size. Turbidimetry and light scattering studies revealed no interaction between the particles and proteins, suggesting the materials will circulate well in vivo.
authors: Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, Florida 32306, USA.
authors: Zaki G
authors: ZG
authors: Estephan
authors: Hanaa H
authors: HH
authors: Hariri
authors: Joseph B
authors: JB
authors: Schlenoff
mesh_terms: D005290:Ferric Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D014867:Water; C000499:ferric oxide