title: Giant renal oncocytoma.
abstract: BACKGROUND
  Renal onkocytoma is a distinctive benign tumor derived from epithelial cells of the distal renal tubules. These tumors are often clinically asymptomatic, diagnosed accidentally and difficult to distinguish from renal cell carcinoma.
  
  
  METHODS
  We presented a giant renal onkocytoma in a man aged 64, without any signs or symptoms of the urogenital system disorder. The preoperative diagnosis described the tumor mass of the right kidney, size 16 x 14 cm, and indicated a malignant tumor of kidney. The patient underwent radical nephrectomy. The tumor was encapsulated at the intersection with the characteristic central hyaline scar. Microscopically, it was built of uniform polygonal cells with abundant eosinophilic cytoplasm. Immunohystochemiclly, tumor cells were immunoreactive to CK AE1/AE3 and CD 117, but showed negative immunoreactivity to CK 7, RCC marker and Vimentin.
  
  
  CONCLUSIONS
  Giant renal oncocytomas are rare tumors with benign clinical course. As a rule, they are discovered by accident. Clinical differentiation from malignant tumors of the kidney is not possible. They are treated surgically, mainly by radical nephrectomy. A definitive diagnosis is made only by histopathological examination of tumors using immunohistochemical marker panels.
authors: Department of Urology, Military Hospital Nis, Nis, Serbia. nesha.stojanovic@gmail.com
authors: Nebojsa
authors: N
authors: Stojanović
authors: Ivan
authors: I
authors: Ignjatovic
authors: Milos
authors: M
authors: Kostov
authors: Zaklina
authors: Z
authors: Mijović
authors: Sladjana
authors: S
authors: Zivković
authors: Branko
authors: B
authors: Kosević
mesh_terms: D018249:Adenoma, Oxyphilic / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged