title: The rs10947803 SNP of KCNK17 is associated with cerebral hemorrhage but not ischemic stroke in a Chinese population.
abstract: KCNK17 (potassium channel, subfamily K, member17) was first discovered to associate with the pathogenesis of ischemic stroke in the first genome-wide association study. The rs10947803 SNP in KCNK17 is significantly associated with ischemic stroke in Caucasian populations. The aim of the present study was to investigate the association with strokes in the Chinese population. A total of 1364 stroke patients and 1293 controls were examined using a case-control methodology. The rs10947803 SNP in KCNK17 was genotyped by a TaqMan real-time PCR assay. The rs10947803 SNP (A allele) of KCNK17 was significantly associated with cerebral hemorrhage (for AA+AC versus CC, unadjusted odds ratio [OR]=1.70; 95% confidence interval [CI], 1.08-2.69; P=0.020). After adjustment for age and sex, the association remained significant for AA+AC versus CC, OR=1.65; 95% CI, 1.04-2.62; P=0.033. In addition, the rs10947803 SNP in KCNK17 was not associated with ischemic stroke (for AA+AC versus CC, unadjusted OR=0.92; 95% CI, 0.81-1.05; P=0.212, after age- and sex-adjustment, OR=0.87; 95% CI, 0.72-1.05; P=0.143). The rs10947803 SNP (A allele) in KCNK17 increases the risk of cerebral hemorrhage but not ischemic stroke in the Chinese population.
authors: Department of Neurology, Xuanwu Hospital, Beijing, China.
authors: Qingfeng
authors: Q
authors: Ma
authors: Yongqin
authors: Y
authors: Wang
authors: Yue
authors: Y
authors: Shen
authors: Xin
authors: X
authors: Liu
authors: Xiaotong
authors: X
authors: Zhu
authors: Hongye
authors: H
authors: Zhang
authors: Lisheng
authors: L
authors: Liu
authors: Xuerui
authors: X
authors: Tan
authors: Lefeng
authors: L
authors: Wang
authors: Xingyu
authors: X
authors: Wang
mesh_terms: D000368:Aged; D044466:Asian People; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D024683:Potassium Channels, Tandem Pore Domain / Q000235:genetics*; D020521:Stroke / Q000209:etiology / Q000235:genetics*
chemical_list: C423407:KCNK17 protein, human; D024683:Potassium Channels, Tandem Pore Domain