title: The Peru Cervical Cancer Prevention Study (PERCAPS): the technology to make screening accessible.
abstract: OBJECTIVE
  This study utilized a combination of HPV self-sampling, iFTA elute specimen cards, and long distance transport for centralized processing of specimens to determine the feasibility of large-scale screening in remote and transient populations.
  
  
  METHODS
  This study was performed in two locations in Peru (Manchay and Iquitos). The "Just For Me" cervico-vaginal brush and iFTA elute cards were used for the collection and transport of specimens. Samples were shipped via FedEx to China and tested for 14 types of high-risk HPV using PCR based MALDI-TOF. HPV positive women were treated with cryotherapy after VIA triage, and followed-up with colposcopy, biopsy, ECC, and repeat HPV testing at 6 months.
  
  
  RESULTS
  Six hundred and forty three women registered, and 632 returned a sample over a 10 day period. Within 2 weeks, specimens were shipped, samples tested, and results received by study staff. Sixty-eight women (10.8%) tested positive, and these results were delivered over 4 days. Fifty-nine HPV positive women (87%) returned for evaluation and treatment, and 2 had large lesions not suitable for cryotherapy. At 6 months, 42 women (74%) returned for follow-up, and 3 had CIN 2 (all positive samples from the endocervical canal). Ninety eight percent of participants reported that they would participate in this type of program again.
  
  
  CONCLUSIONS
  Utilizing HPV self-sampling, solid media specimen cards for long distance transport, and centralized high throughput processing, we achieved rapid delivery of results, high satisfaction levels, and low loss to follow-up for cervical cancer screening in remote and transient populations.
authors: The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA. kimlynnlev@gmail.com
authors: Kimberly L
authors: KL
authors: Levinson
authors: Carolina
authors: C
authors: Abuelo
authors: Jorge
authors: J
authors: Salmeron
authors: Eunice
authors: E
authors: Chyung
authors: Jing
authors: J
authors: Zou
authors: Suzanne E
authors: SE
authors: Belinson
authors: Guixiang
authors: G
authors: Wang
authors: Carlos Santos
authors: CS
authors: Ortiz
authors: Carlos Santiago
authors: CS
authors: Vallejos
authors: Jerome L
authors: JL
authors: Belinson
mesh_terms: D000328:Adult; D017679:Cryotherapy; D055088:Early Detection of Cancer / Q000295:instrumentation / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006297:Health Services Accessibility / Q000458:organization & administration*; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D059012:Lost to Follow-Up; D008403:Mass Screening / Q000295:instrumentation / Q000379:methods* / Q000458:organization & administration; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D010568:Peru; D019035:Rural Health Services / Q000458:organization & administration; D013048:Specimen Handling / Q000295:instrumentation / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control* / Q000821:virology; D014626:Vaginal Smears / Q000295:instrumentation / Q000379:methods*
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