title: Thiourea-catalyzed aminolysis of N-acyl homoserine lactones.
abstract: Thiourea catalysts accelerate aminolysis of N-acyl homoserine lactones (AHLs), molecules integral to bacterial quorum sensing. The catalysts afford rate enhancement of up to 10 times the control in CD(3)CN. Mild catalysis in other polar aprotic solvents is still observed, while the activity is attenuated in polar protic solvents.
authors: Department of Chemistry, University of North Carolina at Chapel Hill, Campus Box 3290, Caudill and Kenan Laboratories, Chapel Hill, NC 27599-3290, USA.
authors: Michael A
authors: MA
authors: Bertucci
authors: Stephen J
authors: SJ
authors: Lee
authors: Michel R
authors: MR
authors: Gagné
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D054742:Acyl-Butyrolactones / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D006090:Gram-Negative Bacteria / Q000502:physiology; D053038:Quorum Sensing; D012997:Solvents / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000097:Acetonitriles; D054742:Acyl-Butyrolactones; D000588:Amines; D012997:Solvents; D013890:Thiourea