title: Damage to ventral and dorsal language pathways in acute aphasia.
abstract: Converging evidence from neuroimaging studies and computational modelling suggests an organization of language in a dual dorsal-ventral brain network: a dorsal stream connects temporoparietal with frontal premotor regions through the superior longitudinal and arcuate fasciculus and integrates sensorimotor processing, e.g. in repetition of speech. A ventral stream connects temporal and prefrontal regions via the extreme capsule and mediates meaning, e.g. in auditory comprehension. The aim of our study was to test, in a large sample of 100 aphasic stroke patients, how well acute impairments of repetition and comprehension correlate with lesions of either the dorsal or ventral stream. We combined voxelwise lesion-behaviour mapping with the dorsal and ventral white matter fibre tracts determined by probabilistic fibre tracking in our previous study in healthy subjects. We found that repetition impairments were mainly associated with lesions located in the posterior temporoparietal region with a statistical lesion maximum in the periventricular white matter in projection of the dorsal superior longitudinal and arcuate fasciculus. In contrast, lesions associated with comprehension deficits were found more ventral-anterior in the temporoprefrontal region with a statistical lesion maximum between the insular cortex and the putamen in projection of the ventral extreme capsule. Individual lesion overlap with the dorsal fibre tract showed a significant negative correlation with repetition performance, whereas lesion overlap with the ventral fibre tract revealed a significant negative correlation with comprehension performance. To summarize, our results from patients with acute stroke lesions support the claim that language is organized along two segregated dorsal-ventral streams. Particularly, this is the first lesion study demonstrating that task performance on auditory comprehension measures requires an interaction between temporal and prefrontal brain regions via the ventral extreme capsule pathway.
authors: Department of Neurology, University Medical Centre Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany. dorothee.kuemmerer@uniklinik-freiburg.de
authors: Dorothee
authors: D
authors: Kümmerer
authors: Gesa
authors: G
authors: Hartwigsen
authors: Philipp
authors: P
authors: Kellmeyer
authors: Volkmar
authors: V
authors: Glauche
authors: Irina
authors: I
authors: Mader
authors: Stefan
authors: S
authors: Klöppel
authors: Julia
authors: J
authors: Suchan
authors: Hans-Otto
authors: HO
authors: Karnath
authors: Cornelius
authors: C
authors: Weiller
authors: Dorothee
authors: D
authors: Saur
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001037:Aphasia / Q000473:pathology* / Q000503:physiopathology; D001307:Auditory Perception / Q000502:physiology; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000473:pathology* / Q000502:physiology; D009434:Neural Pathways / Q000473:pathology / Q000502:physiology; D017397:Prefrontal Cortex / Q000473:pathology* / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D013702:Temporal Lobe / Q000473:pathology* / Q000502:physiology; D055815:Young Adult
references: Neuron. 2011 Oct 20;72(2):385-96
references: 22017995
references: J Cogn Neurosci. 2007 Jul;19(7):1081-8
references: 17583985
references: Neuroimage. 2010 Feb 15;49(4):3187-97
references: 19913624
references: J Neurosci. 2010 Aug 18;30(33):11057-61
references: 20720112
references: Stroke. 2005 May;36(5):986-91
references: 15817891
references: Stroke. 1991 Sep;22(9):1117-23
references: 1926254
references: Nature. 1996 Nov 14;384(6605):159-61
references: 8906789
references: Nat Rev Neurosci. 2007 May;8(5):393-402
references: 17431404
references: J Neurosci. 2007 Oct 24;27(43):11573-86
references: 17959800
references: Nat Rev Neurosci. 2012 Jan 05;13(2):135-45
references: 22218206
references: Brain. 2006 Jun;129(Pt 6):1371-84
references: 16638796
references: Brain Lang. 1977 Oct;4(4):479-91
references: 922463
references: Neuroimage. 2006 May 1;30(4):1414-32
references: 16413796
references: Brain. 2005 Dec;128(Pt 12):2858-71
references: 16234297
references: Nat Neurosci. 2003 May;6(5):448-50
references: 12704393
references: J Comp Neurol. 1988 Jul 1;273(1):52-66
references: 2463275
references: Nat Neurosci. 2009 Jun;12(6):718-24
references: 19471271
references: Arch Neurol. 1990 Oct;47(10):1085-91
references: 2222240
references: Ann Neurol. 1995 Jun;37(6):723-32
references: 7778845
references: Cereb Cortex. 2011 May;21(5):1066-75
references: 20851853
references: Science. 2004 Apr 16;304(5669):438-41
references: 15031438
references: Brain. 2005 Apr;128(Pt 4):797-810
references: 15705610
references: Brain Lang. 2011 Jul;118(1-2):29-39
references: 21429571
references: Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14792-7
references: 9405692
references: Brain. 2009 Dec;132(Pt 12):3411-27
references: 19942676
references: Brain. 1993 Dec;116 ( Pt 6):1509-25
references: 8293284
references: Brain Struct Funct. 2009 Feb;213(3):343-58
references: 19104833
references: Trends Neurosci. 2005 Dec;28(12):636-43
references: 16216346
references: Nervenarzt. 1992 Aug;63(8):473-9
references: 1381813
references: Brain. 2011 Mar;134(Pt 3):903-12
references: 21156661
references: Brain. 2007 Mar;130(Pt 3):630-53
references: 17293361
references: Adv Neurol. 1984;42:291-303
references: 6209953
references: Phys Life Rev. 2009 Sep;6(3):121-43
references: 20161054
references: Neuroimage. 2005 Feb 1;24(3):656-66
references: 15652301
references: Stroke. 2010 Feb;41(2):325-30
references: 20044520
references: Neuroimage. 2008 Oct 15;43(1):81-9
references: 18644243
references: Brain. 2006 Jul;129(Pt 7):1844-58
references: 16702192
references: J Neurosci. 2008 Nov 5;28(45):11435-44
references: 18987180
references: Neuroimage. 2008 Feb 1;39(3):1429-43
references: 18035557
references: Brain. 2009 Dec;132(Pt 12):3401-10
references: 19892765
references: Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):18035-40
references: 19004769
references: Cereb Cortex. 2007 Apr;17(4):816-25
references: 16707738
references: Cognition. 2004 May-Jun;92(1-2):145-77
references: 15037129
references: Stroke. 2006 Nov;37(11):2713-9
references: 17023671
references: Aphasiology. 2012;26(3-4):338-354
references: 24976669
references: Brain. 2002 May;125(Pt 5):1094-104
references: 11960898
references: Cereb Cortex. 2004 Oct;14(10):1164-72
references: 15142954
references: Br Med Bull. 2003;65:95-119
references: 12697619
references: J Cogn Neurosci. 2001 May 15;13(4):419-29
references: 11388916
references: Neuroimage. 2012 Feb 15;59(4):3514-21
references: 22100771
references: J Cogn Neurosci. 2003 Jul 1;15(5):673-82
references: 12965041