title: The effect of head orientation on subarachnoid cerebrospinal fluid distribution and its implications for neurophysiological modulation and recording techniques.
abstract: Gravitational forces may lead to local changes in subarachnoid cerebrospinal fluid (CSF) layer thickness, which has important implications for neurophysiological modulation and recording techniques. This study examines the effect of gravitational pull associated with different head positions on the distribution of subarachnoid CSF using structural magnetic resonance imaging. Images of seven subjects in three different positions (supine, left lateral and prone) were statistically compared. Results suggest that subarachnoid CSF volume decreases on the side of the head closest to the ground, due to downward brain movement with gravity. These findings warrant future research into currently unexplored gravitation-induced changes in regional subarachnoid CSF thickness.
authors: Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, University of Sheffield, Sheffield, UK. Janine.Bijsterbosch@ndcn.ox.ac.uk
authors: Janine D
authors: JD
authors: Bijsterbosch
authors: Kwang-Hyuk
authors: KH
authors: Lee
authors: Michael D
authors: MD
authors: Hunter
authors: Iain D
authors: ID
authors: Wilkinson
authors: Tom
authors: T
authors: Farrow
authors: Anthony T
authors: AT
authors: Barker
authors: Peter W R
authors: PW
authors: Woodruff
mesh_terms: D000328:Adult; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D005260:Female; D006257:Head / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009068:Movement / Q000502:physiology*; D009424:Nervous System Physiological Phenomena; D013346:Subarachnoid Space / Q000378:metabolism*