title: Localised interventions in cellular processes.
abstract: The once linear view of cell regulatory processes is now changing as we begin to overlay spatial and temporal characteristics onto signalling pathways and dynamic membranous events. To better understand the properties of these spatially restricted processes we must refine our targeting of these events with acute localised manipulations. We review here the diverse application of a dimerisation system, which exploits immunosuppressor/immunophilin biology to provide a route to drug-inducible subdomain interventions. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012).
authors: Protein Phosphorylation Laboratory London Research Institute, London, UK. Nick.Peel@cancer.org.uk
authors: Nick
authors: N
authors: Peel
authors: Banafshé
authors: B
authors: Larijani
authors: Peter J
authors: PJ
authors: Parker
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002468:Cell Physiological Phenomena / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism*; D055503:Protein Multimerization; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
chemical_list: D047428:Protein Kinase Inhibitors; D011494:Protein Kinases