title: Transient improvement of poststroke apathy with zolpidem: a single-case, placebo-controlled double-blind study.
abstract: We report the case of a 44-year-old patient with severe and disabling apathy nearly 2 years after a right hemisphere haemorrhagic stroke. The effect of a single dose of zolpidem was tested over a 2-week period, in alternation with either no treatment or a placebo in a double-blind randomised trial. Zolpidem was associated with a dramatic improvement in apathy, as assessed with the Apathy Inventory and the Behavioral Dysexecutive Syndrome Inventory. No adverse effect occurred during the trial.
authors: Department of PM&R,  Pole St Helier, Rennes,  France.
authors: Katell
authors: K
authors: Autret
authors: Annabelle
authors: A
authors: Arnould
authors: Sarah
authors: S
authors: Mathieu
authors: Philippe
authors: P
authors: Azouvi
mesh_terms: D000328:Adult; D057565:Apathy; D004311:Double-Blind Method; D058785:GABA-A Receptor Agonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011725:Pyridines / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy / Q000523:psychology*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D000077334:Zolpidem
chemical_list: D058785:GABA-A Receptor Agonists; D011725:Pyridines; D000077334:Zolpidem
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