title: Image-guided resection of malignant gliomas using ﬂuorescent nanoparticles.
abstract: Intraoperative fluorescence imaging especially near-infrared fluorescence (NIRF) imaging has the potential to revolutionize neurosurgery by providing high sensitivity and real-time image guidance to surgeons for defining gliomas margins. Fluorescence probes including targeted nanoprobes are expected to improve the specificity and selectivity for intraoperative fluorescence or NIRF tumor imaging. The main focus of this article is to provide a brief overview of intraoperative fluorescence imaging systems and probes including fluorescein sodium, 5-aminolevulinic acid, dye-containing nanoparticles, and targeted NIRF nanoprobes for their applications in image-guided resection of malignant gliomas. Moreover, photoacoustic imaging is a promising molecular imaging modality, and its potential applications for brain tumor imaging are also briefly discussed.
authors: Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Stanford, CA, USA.
authors: Xinhui
authors: X
authors: Su
authors: Kai
authors: K
authors: Cheng
authors: Charlie
authors: C
authors: Wang
authors: Lei
authors: L
authors: Xing
authors: Hua
authors: H
authors: Wu
authors: Zhen
authors: Z
authors: Cheng
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000601:surgery*; D002986:Clinical Trials as Topic; D005453:Fluorescence; D005910:Glioma / Q000601:surgery*; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D025321:Surgery, Computer-Assisted
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