title: EGF +61A>G polymorphism and gastrointestinal cancer risk: a HuGE review and meta-analysis.
abstract: Emerging evidences from preclinical and clinical studies have shown that epidermal growth factor (EGF) has some effectiveness against endogenously arising carcinogenesis. Functional +61A>G polymorphism (rs4444903 A>G) in the promoter region of the EGF gene was observed to modulate EGF levels, thus affecting the susceptibility to gastrointestinal cancer; but individually published studies showed inconclusive results. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to derive a more precise estimation of the association between EGF +61A>G polymorphism and gastrointestinal cancer risk. A literature search of Pubmed, Embase, Web of Science and Chinese BioMedical databases from inception through July 2012 was conducted. Twelve studies were assessed with a total of 2868 gastrointestinal cancer cases and 4278 healthy controls. When all the eligible studies were pooled into the meta-analysis, the results showed that the G allele and GG genotype of EGF +61A>G polymorphism might increase the risk of gastrointestinal cancer. In the stratified analysis by cancer types, the G allele and GG genotype of EGF +61A>G polymorphism showed displayed significant correlations with increased risk of esophageal cancer. We also found significant correlations between the G carrier (GG+AG) and GG genotype of EGF +61A>G polymorphism and colorectal cancer risk. However, EGF +61A>G polymorphism did not appear to have an influence on gastric cancer susceptibility. Results from the current meta-analysis indicate that EGF +61A>G polymorphism might increase the risk of esophageal and colorectal cancers. Nevertheless, further studies are needed to determine whether genetic associations between EGF +61A>G polymorphism and susceptibility to gastric cancer are significant.
authors: Department of Oncology, Cancer Treatment Center, General Hospital of Shenyang Military Region, Shenyang 110840, China.
authors: Ying
authors: Y
authors: Piao
authors: Zhaozhe
authors: Z
authors: Liu
authors: Zhenyu
authors: Z
authors: Ding
authors: Long
authors: L
authors: Xu
authors: Fang
authors: F
authors: Guo
authors: Qingqing
authors: Q
authors: Sun
authors: Xiaodong
authors: X
authors: Xie
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D030541:Databases, Genetic; D004815:Epidermal Growth Factor / Q000235:genetics* / Q000378:metabolism; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D004815:Epidermal Growth Factor