title: Multiple myeloma and occupation: a pooled analysis by the International Multiple Myeloma Consortium.
abstract: OBJECTIVE
  We investigated occupational risk of multiple myeloma (MM) in a pooled analysis of five international case-control studies.
  
  
  METHODS
  We calculated the odds ratio and its 95% confidence interval for selected occupations with unconditional regression analysis in 1959 MM cases and 6192 controls, by pooling study-specific risks using random-effects meta-analysis. Exposure to organic solvents was assessed with a job-exposure matrix (JEM).
  
  
  RESULTS
  Gardeners and nursery workers combined, most likely exposed to pesticides, showed a 50% increase in risk (OR = 1.50, 95% CI 0.9-2.3), while other farming jobs did not. Metal processors (OR = 1.55, 95% CI 0.9-2.3), female cleaners (OR = 1.32, 95% CI 1.0-1.8), and high level exposure to organic solvents (OR = 1.38, 95% CI 0.96-1.8) also showed moderately increased risks.
  
  
  CONCLUSIONS
  Additional case-control studies of MM aetiology are warranted to further investigate the nature of the repeatedly reported increase in MM risk in several occupational groups.
authors: Family and Community Medicine Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
authors: Carla
authors: C
authors: Perrotta
authors: Silke
authors: S
authors: Kleefeld
authors: Anthony
authors: A
authors: Staines
authors: Prerna
authors: P
authors: Tewari
authors: Anneclaire J
authors: AJ
authors: De Roos
authors: Dalsu
authors: D
authors: Baris
authors: Brenda
authors: B
authors: Birmann
authors: Brian
authors: B
authors: Chiu
authors: Wendy
authors: W
authors: Cozen
authors: Nikolaus
authors: N
authors: Becker
authors: Lenka
authors: L
authors: Foretova
authors: Marc
authors: M
authors: Maynadié
authors: Alexandra
authors: A
authors: Nieters
authors: Silvia
authors: S
authors: de Sanjosé
authors: Lucia
authors: L
authors: Miligi
authors: Adele
authors: A
authors: Seniori Costantini
authors: Mark
authors: M
authors: Purdue
authors: John
authors: J
authors: Spinelli
authors: Pierluigi
authors: P
authors: Cocco
mesh_terms: D016022:Case-Control Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000453:epidemiology* / Q000209:etiology; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure / Q000706:statistics & numerical data; D009790:Occupations / Q000706:statistics & numerical data; D012307:Risk Factors; D014481:United States / Q000453:epidemiology