title: Sensing bacteria, without bitterness?
abstract: In addition to their recognized roles in intra- and inter-species signaling, bacterial quorum-sensing molecules have been implicated in inter-kingdom signaling. A new study in Pseudomonas aeruginosa suggests that mammalian bitter taste receptors may recognize bacterial quorum sensing molecules, and widens the scope of such inter-kingdom communication. Intestinal cells also harbor these receptors, but whether they eavesdrop on bacterial conversations remains an open question.
authors: Veterinary Science and Microbiology, University of Arizona, Tucson, AZ USA. vkv@email.arizona.edu
authors: V K
authors: VK
authors: Viswanathan
mesh_terms: D054742:Acyl-Butyrolactones / Q000378:metabolism*; D000818:Animals; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D008954:Models, Biological; D011550:Pseudomonas aeruginosa / Q000378:metabolism* / Q000502:physiology*; D053038:Quorum Sensing; D043562:Receptors, G-Protein-Coupled / Q000819:agonists*; D000098706:Taste Receptors, Type 2
chemical_list: D054742:Acyl-Butyrolactones; D043562:Receptors, G-Protein-Coupled; D000098706:Taste Receptors, Type 2
keywords: Acyl homoserine lactone; T2R38; bitter; quorum sensing; taste receptor
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