title: GPR34 as a lysophosphatidylserine receptor.
abstract: GPR34, a P2Y receptor family member, was identified as a candidate lysophosphatidylserine (LysoPS) receptor in 2006. However, it was controversial whether LysoPS is a real ligand for GPR34. Kitamura et al. (GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position. J. Biochem. 2012;151:511-518), using several methods for detecting activation of G protein-coupled receptor (GPCR) and chemically synthesized LysoPS analogues, concluded that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position. Furthermore, three additional GPCRs belonging to the P2Y family were recently identified as GPCRs for LysoPS, supporting the idea that GPR34 is a LysoPS receptor.
authors: Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan.
authors: Kumiko
authors: K
authors: Makide
authors: Junken
authors: J
authors: Aoki
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D049312:Receptors, Lysophospholipid / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D008246:Lysophospholipids; D049312:Receptors, Lysophospholipid