title: Monocyte signal transduction receptors in active and latent tuberculosis.
abstract: The mechanisms that promote either resistance or susceptibility to TB disease remain insufficiently understood. Our aim was to compare the expression of cell signaling transduction receptors, CD14, TLR2, CD206, and β2 integrin LFA-1 on monocytes from patients with active TB or nonmycobacterial lung disease and healthy individuals with M.tb latency and uninfected controls to explain the background of the differences between clinical and subclinical forms of M.tb infection. A simultaneous increase in the expression of the membrane bound mCD14 receptor and LFA-1 integrin in patients with active TB may be considered a prodrome of breaking immune control by M.tb bacilli in subjects with the latent TB and absence of clinical symptoms.
authors: Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.
authors: Magdalena
authors: M
authors: Druszczynska
authors: Marcin
authors: M
authors: Wlodarczyk
authors: Beata
authors: B
authors: Janiszewska-Drobinska
authors: Grzegorz
authors: G
authors: Kielnierowski
authors: Joanna
authors: J
authors: Zawadzka
authors: Magdalena
authors: M
authors: Kowalewicz-Kulbat
authors: Marek
authors: M
authors: Fol
authors: Piotr
authors: P
authors: Szpakowski
authors: Karolina
authors: K
authors: Rudnicka
authors: Magdalena
authors: M
authors: Chmiela
authors: Wieslawa
authors: W
authors: Rudnicka
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D018821:CD18 Antigens / Q000378:metabolism; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000276:immunology*; D037181:Lectins, C-Type / Q000378:metabolism; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism*; D008297:Male; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology* / Q000382:microbiology; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000378:metabolism; D017452:Receptors, IgG / Q000378:metabolism*; D015398:Signal Transduction; D051195:Toll-Like Receptor 2 / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018821:CD18 Antigens; D037181:Lectins, C-Type; D016169:Lymphocyte Function-Associated Antigen-1; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D017452:Receptors, IgG; D051195:Toll-Like Receptor 2
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