title: The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis.
abstract: OBJECTIVE
  The variable number of tandem repeats (VNTR) in the last exon of the carboxyl-ester lipase (CEL) gene has been reported to associate with alcohol-induced chronic pancreatitis (ACP) in a Japanese study. Here, we have investigated the association between the number of CEL VNTR repeats and ACP or idiopathic chronic pancreatitis (ICP) in a cohort of German patients.
  
  
  METHODS
  Patients diagnosed with ACP (n = 203) or ICP (n = 64) were genotyped using a screening method consisting of PCR followed by DNA fragment analysis. The allele frequencies of different CEL VNTR lengths were compared to the frequencies in healthy controls (n = 390).
  
  
  RESULTS
  We observed no statistical significant associations between CEL VNTR allele frequencies and ACP or ICP.
  
  
  CONCLUSIONS
  This study did not find evidence that supported an association between the common length variations of the CEL VNTR and chronic pancreatitis.
authors: KG Jebsen Center for Diabetes Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
authors: Anja
authors: A
authors: Ragvin
authors: Karianne
authors: K
authors: Fjeld
authors: F Ulrich
authors: FU
authors: Weiss
authors: Janniche
authors: J
authors: Torsvik
authors: Ali
authors: A
authors: Aghdassi
authors: Julia
authors: J
authors: Mayerle
authors: Peter
authors: P
authors: Simon
authors: Pål R
authors: PR
authors: Njølstad
authors: Markus M
authors: MM
authors: Lerch
authors: Stefan
authors: S
authors: Johansson
authors: Anders
authors: A
authors: Molven
mesh_terms: D000437:Alcoholism / Q000150:complications* / Q000235:genetics; D015331:Cohort Studies; D005787:Gene Frequency; D005858:Germany; D006801:Humans; D008049:Lipase / Q000235:genetics*; D050500:Pancreatitis, Chronic / Q000235:genetics*; D012307:Risk Factors
chemical_list: C054621:CEL protein, human; D008049:Lipase