title: Gene-environment correlation in the development of adolescent substance abuse: selection effects of child personality and mediation via contextual risk factors.
abstract: We used a longitudinal twin design to examine selection effects of personality traits at age 11 on high-risk environmental contexts at age 14 and the extent to which these contexts mediated risk for substance abuse at age 17. Socialization at age 11 (willingness to follow rules and endorse conventional values) predicted exposure to contextual risk at age 14. Contextual risk partially mediated the effect of socialization on substance abuse, though socialization also had a direct effect. In contrast, boldness at age 11 (social engagement and assurance, thrill seeking, and stress resilience) also predicted substance abuse directly but was unrelated to contextual risk. There was substantial overlap in the genetic and shared environmental influences on socialization and contextual risk, and genetic risk in socialization contributed to substance abuse indirectly via increased exposure to contextual risk. This suggests that active gene-environment correlations related to individual differences in socialization contributed to an early, high-risk developmental trajectory for adolescent substance abuse. In contrast, boldness appeared to index an independent and direct genetic risk factor for adolescent substance abuse.
authors: Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI 48109, USA. brianhic@umich.edu
authors: Brian M
authors: BM
authors: Hicks
authors: Wendy
authors: W
authors: Johnson
authors: C Emily
authors: CE
authors: Durbin
authors: Daniel M
authors: DM
authors: Blonigen
authors: William G
authors: WG
authors: Iacono
authors: Matt
authors: M
authors: McGue
mesh_terms: D000293:Adolescent; D002648:Child; D004200:Diseases in Twins / Q000209:etiology* / Q000235:genetics / Q000523:psychology; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D008297:Male; D012307:Risk Factors; D012931:Social Environment; D012951:Socialization; D019966:Substance-Related Disorders / Q000209:etiology* / Q000235:genetics / Q000523:psychology; D014427:Twins / Q000235:genetics* / Q000523:psychology
references: Psychol Bull. 1992 Jul;112(1):64-105
references: 1529040
references: Behav Genet. 2006 Jul;36(4):591-602
references: 16557361
references: J Abnorm Psychol. 2004 Aug;113(3):440-50
references: 15311989
references: Drug Alcohol Depend. 1998 Jan 1;49(2):115-21
references: 9543648
references: Annu Rev Psychol. 2005;56:235-62
references: 15709935
references: J Pers Soc Psychol. 2004 May;86(5):744-59
references: 15161398
references: Twin Res Hum Genet. 2008 Jun;11(3):257-65
references: 18498204
references: Dev Psychopathol. 2014 Feb;26(1):141-57
references: 24280373
references: J Abnorm Psychol. 1996 Aug;105(3):299-312
references: 8772001
references: J Abnorm Psychol. 2011 Feb;120(1):253-8
references: 20973594
references: Psychol Rev. 1993 Oct;100(4):674-701
references: 8255953
references: J Clin Child Psychol. 2001 Sep;30(3):316-26
references: 11501249
references: Dev Psychopathol. 1998 Summer;10(3):469-93
references: 9741678
references: J Am Acad Child Adolesc Psychiatry. 1987 Sep;26(5):649-53
references: 3667494
references: Child Dev. 1983 Apr;54(2):424-35
references: 6683622
references: J Abnorm Psychol. 2006 Feb;115(1):85-95
references: 16492099
references: Arch Gen Psychiatry. 2003 May;60(5):505-13
references: 12742872
references: Annu Rev Clin Psychol. 2008;4:325-48
references: 18370620
references: J Pers. 2000 Feb;68(1):29-50
references: 10820680
references: Psychol Addict Behav. 2011 Sep;25(3):390-404
references: 21823762
references: Child Dev. 2005 Sep-Oct;76(5):1055-71
references: 16150002
references: J Child Psychol Psychiatry. 2005 Mar;46(3):235-45
references: 15755300
references: J Pers Soc Psychol. 1986 Dec;51(6):1173-82
references: 3806354
references: Arch Gen Psychiatry. 2009 Jun;66(6):640-8
references: 19487629
references: Am Psychol. 1990 May;45(5):612-30
references: 2350080
references: Annu Rev Clin Psychol. 2005;1:493-523
references: 17716097
references: Dev Psychopathol. 1999 Fall;11(4):869-900
references: 10624730
references: J Stud Alcohol Drugs. 2009 Jul;70(4):489-98
references: 19515288
references: Am Psychol. 1986 Jul;41(7):783-93
references: 3527004
references: J Abnorm Psychol. 1999 Feb;108(1):106-19
references: 10066997
references: J Child Psychol Psychiatry. 2006 Feb;47(2):151-9
references: 16423146
references: Twin Res Hum Genet. 2009 Oct;12(5):489-501
references: 19803776
references: Dev Psychopathol. 2009 Summer;21(3):913-38
references: 19583890
references: Am Psychol. 1989 Feb;44(2):329-35
references: 2653143
references: Twin Res. 2002 Dec;5(6):554-71
references: 12573187
references: J Consult Clin Psychol. 2002 Dec;70(6):1224-39
references: 12472299
references: J Pers Soc Psychol. 2009 Aug;97(2):351-62
references: 19634980
references: Psychol Med. 2000 Nov;30(6):1303-13
references: 11097071
references: Psychol Bull. 2000 Jan;126(1):3-25
references: 10668348
references: J Abnorm Child Psychol. 2014;42(5):845-59
references: 24337735
references: Psychol Bull. 2006 Jan;132(1):1-25
references: 16435954
references: Alcohol Clin Exp Res. 2010 May;34(5):819-33
references: 20184563
references: Psychol Rev. 2006 Jan;113(1):101-31
references: 16478303
references: Addiction. 2004 Dec;99(12):1548-59
references: 15585046
references: Twin Res Hum Genet. 2007 Feb;10(1):45-53
references: 17539364
references: J Pers Soc Psychol. 2001 Oct;81(4):670-83
references: 11642353
references: J Pers. 2008 Apr;76(2):229-66
references: 18331280
references: J Child Psychol Psychiatry. 2003 Nov;44(8):1092-115
references: 14626453