title: TNF-β +252 A>G polymorphism and susceptibility to cancer.
abstract: OBJECTIVE
  Tumor necrosis factor-β (TNF-β) plays important roles in mediating cancer development. Many studies have argued possible associations of TNF-β +252 A>G polymorphism with different cancers. However, association between this most frequently studied polymorphism and susceptibility to cancer still remains controversial and ambiguous. The aim of this study is to determine the relationship of TNF-β +252 A>G polymorphism with cancer through meta-analysis.
  
  
  METHODS
  Electronic searches of several databases were conducted for all publications on the associations between this variant and cancer through October 2011. Odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were used to access the strength of this association in random-effect model.
  
  
  RESULTS
  Thirty-three studies with 14,435 cancer patients and 10,583 healthy controls were included. In this meta-analysis, we detected statistically significant connections between this polymorphism and cancer risks [GG + GA vs. AA: OR = 1.24, 95 % CI = 1.02-1.51; GG vs. AA: OR = 1.43, 95 % CI = 1.05-1.95; G vs. A: OR = 1.28, 95 % CI = 1.28 (1.09-1.50)] in the overall ethnic population. Meanwhile, we detected significant associations in Asian population (GG + GA vs. AA), other population (GG vs. GA + AA), and Caucasian population (GG vs. AA, G vs. A) with the OR values being 1.21 (1.04-1.40), 1.64 (1.35-1.99), 1.65 (1.02, 2.65), and 1.39 (1.09-1.75), respectively.
  
  
  CONCLUSIONS
  TNF-β +252 A>G polymorphism is positively associated with susceptibility to cancer. However, this study also suggests that more studies should be conducted to further confirm the associations between this variant and specific types of cancers.
authors: Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, 23 Youzheng St., Nangang District, Harbin 150001, People's Republic of China.
authors: Lin
authors: L
authors: Yang
authors: Rennan
authors: R
authors: Feng
authors: Guiyou
authors: G
authors: Liu
authors: Mingzhi
authors: M
authors: Liao
authors: Liangcai
authors: L
authors: Zhang
authors: Wenbo
authors: W
authors: Wang
mesh_terms: D000483:Alleles; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: D008233:Lymphotoxin-alpha
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