title: Recurrence of infantile cortical hyperostosis:  a case report and review of the literature.
abstract: OBJECTIVE
  Also named Caffey disease, infantile cortical hyperostosis is a rare disease that usually affects children of a few weeks of age. The clinical picture is that of irritability, soft tissue swelling at various sites (mandible, clavicle, limbs) with local warmth, and pain on palpation. Radiographs demonstrate an important cortical thickening of the affected bony structures. There is generally spontaneous resolution of the inflammatory signs within the first few months or years of life, without future recurrence. We report the case of a recurrence in the adolescent period and conducted a thorough review of the literature to confirm this rare possibility.
  
  
  METHODS
  We report the case of a 12-year-old female patient, presenting symptoms of pain and swelling of both forearms and legs, similar to her initial clinical picture at 1 month of age when the diagnosis of Caffey disease was made. Genetic analysis confirmed the COL1A1 mutation, the classic mutation described in the familial form of this disease. Radiologic investigation revealed new periosteal bone formation of the right and left ulnae and the left fibula, suggesting a recurrence of cortical hyperostosis. A thorough review of the literature was conducted, using the Medline database between 1948 and 2011, to confirm this hypothesis.
  
  
  RESULTS
  The literature confirms the possibility but also the rarity of a recurrence of cortical hyperostosis in an adolescent who was diagnosed with Caffey disease in infancy. We have identified less than a dozen cases in the literature describing such a recurrence and in the majority there are no medical photographs or radiographs to support the clinical diagnosis. Our case is well documented both clinically and radiologically regarding the initial presentation and the recurrence in adolescence.
  
  
  CONCLUSIONS
  Although very rare and poorly recognized, the diagnosis of recurrent cortical hyperostosis must be evoked in a patient who suffered from Caffey disease in infancy, and presents similar clinical characteristics in the adolescent period.
  
  
  METHODS
  Level V--case report.
authors: Hôpital Sainte-Justine, Université de Montréal, Montréal, QC, Canada. navarre.pierre@gmail.com
authors: Pierre
authors: P
authors: Navarre
authors: Ivaylo
authors: I
authors: Pehlivanov
authors: Benoit
authors: B
authors: Morin
mesh_terms: D002648:Child; D024042:Collagen Type I / Q000235:genetics*; D000090602:Collagen Type I, alpha 1 Chain; D005260:Female; D006801:Humans; D006958:Hyperostosis, Cortical, Congenital / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D009154:Mutation; D012008:Recurrence
chemical_list: D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain