title: Self-assembly of anionic porphyrins and alkaline or alkaline earth metal ions mediated by cucurbit[7,8]uril.
abstract: Nanoscaled coordination polymers based on biologically prevalent ions have potential applications in drug delivery and biomedical imaging. Herein, coordination polymer nanoparticles of anionic porphyrins, including meso-tetra(4-carboxyphenyl)-porphyrin (H2 TCPP(4-)) and meso-tetra(4-sulfonatophenyl)-porphyrin (H2 TPPS(4-)), and alkaline or alkaline earth metal cations, such as K(+) and Ca(2+), were constructed in aqueous solution in the presence of cucurbit[7]uril (CB7) or cucurbit[8]uril (CB8). UV/Vis absorption and fluorescence spectroscopy, dynamic light scattering (DLS), scanning electron spectroscopy (SEM), and atomic force microscopy (AFM) were applied to explore the assembly and particle formation of porphyrin anions and metal cations mediated by CBn. The particle size depends on the kinds of CBn and metal cations and their concentrations. The uptake of H2 TPPS(4-) particles by tumor cells (A549 cells) was found to be more efficient than H2 TPPS(4-) at 37 °C, showing the application potential of such assembled particles in biology and medicine.
authors: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors: Wanhua
authors: W
authors: Lei
authors: Guoyu
authors: G
authors: Jiang
authors: Qianxiong
authors: Q
authors: Zhou
authors: Yuanjun
authors: Y
authors: Hou
authors: Baowen
authors: B
authors: Zhang
authors: Xuexin
authors: X
authors: Cheng
authors: Xuesong
authors: X
authors: Wang