title: The microbiome explored: recent insights and future challenges.
abstract: One of the most exciting scientific advances in recent years has been the realization that commensal microorganisms are not simple 'passengers' in our bodies, but instead have key roles in our physiology, including our immune responses and metabolism, as well as in disease. These insights have been obtained, in part, through the work of large-scale, consortium-driven metagenomic projects. Here, five experts in the field of microbiome research discuss the most surprising and exciting new findings, and outline the future steps that will be necessary to elucidate the numerous roles of the microbiota in human health and disease and to develop viable therapeutic strategies.
authors: Department of Medicine, New York University Langone Medical Center, New York, New York 10016, USA. Martin.Blaser@med.nyu.edu
authors: Martin
authors: M
authors: Blaser
authors: Peer
authors: P
authors: Bork
authors: Claire
authors: C
authors: Fraser
authors: Rob
authors: R
authors: Knight
authors: Jun
authors: J
authors: Wang
mesh_terms: D035843:Biomedical Research / Q000639:trends; D003141:Communicable Diseases; D006262:Health; D006801:Humans; D054892:Metagenome; D056186:Metagenomics / Q000379:methods; D013559:Symbiosis
references: Cell. 2012 Jun 22;149(7):1578-93
references: 22726443
references: Nature. 2012 Aug 30;488(7413):621-6
references: 22914093
references: Cell. 2012 Aug 3;150(3):470-80
references: 22863002
references: Nat Rev Microbiol. 2009 Dec;7(12):887-94
references: 19898491
references: Science. 2012 Apr 27;336(6080):489-93
references: 22442383
references: N Engl J Med. 2013 Jan 31;368(5):407-15
references: 23323867