title: Development and validation of a pressure-type automated quantitative sensory testing system for point-of-care pain assessment.
abstract: Quantitative sensory testing (QST) can provide useful information about the underlying mechanisms involved in chronic pain. However, currently available devices typically employed suffer from operator-dependent effects, or are too cumbersome for routine clinical care. This paper presents the design and initial validation of a novel automated pressure-pain type QST platform, termed the multi-modal automated sensory testing (MAST) system. The MAST configuration presented consists of wireless, hand-held thumbnail pressure stimulators (with circular 10 mm² rubber tips) and graphical touch screen interface devices to manage the QST process and obtain patient feedback. Validation testing of the custom-designed force sensor showed a 1 % error for low forces increasing to 2 % error for larger loads up to 100 N (full-scale). Validation of the controller using three ramp rates (64, 248, and 496 kPa/s) and six pressures (32, 62, 124, 273, 620, and 1116 kPa) showed an overall mean error of 1.7 % for applied stimuli. Clinical evaluation revealed decreased pressure pain thresholds in chronic pain patients (98.07 ± SE 16.34 kPa) compared to pain free, healthy control subjects (259.88 ± SE 33.54 kPa, p = 0.001). The MAST system is portable and produces accurate, repeatable stimulation profiles indicating potential for point-of-care applications.
authors: Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan Medical School, Ann Arbor, MI 48106, USA.
authors: Steven E
authors: SE
authors: Harte
authors: Mainak
authors: M
authors: Mitra
authors: Eric A
authors: EA
authors: Ichesco
authors: Megan E
authors: ME
authors: Halvorson
authors: Daniel J
authors: DJ
authors: Clauw
authors: Albert J
authors: AJ
authors: Shih
authors: Grant H
authors: GH
authors: Kruger
mesh_terms: D000328:Adult; D059350:Chronic Pain / Q000175:diagnosis*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008875:Middle Aged; D010147:Pain Measurement / Q000295:instrumentation* / Q000379:methods; D017288:Pain Threshold / Q000502:physiology; D010353:Patient Education as Topic / Q000379:methods; D019095:Point-of-Care Systems
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