title: [Possible clinical potential in reverting muscular block with sugammadex in anaesthesia and surgery].
abstract: Neuromuscular blockers (NMBs) provide good conditions for endotracheal intubation and surgery. NMBs have been associated with higher morbidity and mortality, mainly due to post-operative residual neuromuscular block. This may become history with the advent of sugammadex - an antidote to the NMB rocuronium - which within 1-3 minutes neutralizes the effects of rocuronium. High-dose rocuronium is now an alternative to suxamethonium in acute or short procedures and in a situation, where ventilation/intubating cannot be performed, sugammadex can reverse the rocuronium blockade within minutes.
authors: Anæstesiologisk Afdeling, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark. emilieberthelsen@hotmail.com
authors: Emilie
authors: E
authors: Øberg
authors: Casper
authors: C
authors: Claudius
mesh_terms: D000732:Androstanols / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology; D000758:Anesthesia / Q000379:methods; D000762:Anesthesia Recovery Period; D006801:Humans; D007442:Intubation, Intratracheal; D009388:Neostigmine / Q000494:pharmacology; D019148:Neuromuscular Blockade / Q000379:methods; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology; D000077123:Rocuronium; D000077122:Sugammadex; D013997:Time Factors; D047408:gamma-Cyclodextrins / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D009388:Neostigmine; D000077123:Rocuronium