title: CD133 is a predictor of poor survival in head and neck squamous cell carcinomas.
abstract: BACKGROUND
  The pentaspan protein CD133 (Prominin-1) is a predictive marker and part of the signature of tumour-initiating cells (TICs) for various cancer entities.
  
  
  METHODS
  The correlation of CD133 expression with clinical parameters was assessed in primary samples of head and neck squamous cell carcinomas (n=98) and normal mucosas (n=24).
  
  
  RESULTS
  A gradual and inversely proportional correlation between CD133 expression in primary tumours and decreased overall survival was observed, along with a positive correlation with the presence of lymph node metastases.
  
  
  CONCLUSIONS
  CD133 has the potential of being a novel clinically relevant prognostic marker for head and neck malignancies, which is possibly involved in regulation of tumourigenicity.
authors: Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig Maximilians University of Munich, Munich, Germany. martin.canis@med.uni-goettingen.de
authors: Martin
authors: M
authors: Canis
authors: Axel
authors: A
authors: Lechner
authors: Brigitte
authors: B
authors: Mack
authors: Pamela
authors: P
authors: Zengel
authors: Rüdiger Paul
authors: RP
authors: Laubender
authors: Udo
authors: U
authors: Koehler
authors: Vigo
authors: V
authors: Heissmeyer
authors: Olivier
authors: O
authors: Gires
mesh_terms: D000071916:AC133 Antigen; D015703:Antigens, CD / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism*; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides