title: Periodontal disease and risk of psoriasis among nurses in the United States.
abstract: OBJECTIVE
  Periodontal disease has been associated with systemic inflammation and may be a risk factor for autoimmune diseases. This study evaluated the association between periodontal disease and the risk of incident psoriasis in a large prospective cohort study.
  
  
  METHODS
  Self-reported history of periodontal bone loss, from 1998-2008, was evaluated as a risk factor for incident psoriasis among 60,457 women in the Nurses' Health Study. Secondary analyses examined associations between history of tooth loss and number of natural teeth and psoriasis risk. Cox proportional hazards models were used to assess multivariate estimates, adjusting for age, cigarette smoking, body mass index, alcohol intake and physical activity.
  
  
  RESULTS
  An increased multivariate risk of psoriasis was observed for those with mild periodontal bone loss (RR = 1.35, 95% CI = 1.03-1.75) and moderate-to-severe periodontal bone loss (RR = 1.49, 95% CI = 1.08-2.05), as compared to those without periodontal bone loss, after adjusting for age, cigarette smoking, body mass index, alcohol intake, physical activity and tooth loss. Number of natural teeth and tooth loss were not associated with risk of psoriasis in this study.
  
  
  CONCLUSIONS
  This study shows that a history of periodontal bone loss may increase risk of subsequent psoriasis. A limitation of this study is that it is based on self-reported measures.
authors: Department of Dermatology, Johns Hopkins Medical Center , Baltimore, MD , USA.
authors: Sarah
authors: S
authors: Nakib
authors: Jiali
authors: J
authors: Han
authors: Tricia
authors: T
authors: Li
authors: Kaumudi
authors: K
authors: Joshipura
authors: Abrar A
authors: AA
authors: Qureshi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D009740:Nursing Staff; D010510:Periodontal Diseases / Q000150:complications*; D015995:Prevalence; D011446:Prospective Studies; D011565:Psoriasis / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
references: J Periodontol. 1998 Feb;69(2):269-78
references: 9526927
references: Oral Microbiol Immunol. 2000 Aug;15(4):232-7
references: 11154408
references: Epidemiology. 1990 Nov;1(6):466-73
references: 2090285
references: Am J Epidemiol. 1986 May;123(5):894-900
references: 3962971
references: Acta Odontol Scand. 2010 May;68(3):165-70
references: 20141361
references: Br J Dermatol. 2009 Oct;161(4):778-84
references: 19566664
references: J Clin Periodontol. 2006 Jun;33(6):401-7
references: 16677328
references: J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):434-44
references: 15761421
references: J Dermatol Sci. 2008 Jun;50(3):197-207
references: 18308514
references: J Periodontol. 2007 Jul;78(7 Suppl):1429-38
references: 17608614
references: J Rheumatol. 2010 Sep;37(9):1800-4
references: 20595268
references: J Periodontol. 2008 Jun;79(6):993-8
references: 18533775
references: J Immunol. 2006 Dec 15;177(12):8296-300
references: 17142724
references: Arch Dermatol. 2001 Mar;137(3):280-4
references: 11255325
references: J Leukoc Biol. 2009 Aug;86(2):435-43
references: 19487306
references: J Am Acad Dermatol. 2006 Apr;54(4):685-704
references: 16546593
references: J Am Acad Dermatol. 2005 Jan;52(1):23-6
references: 15627076
references: J Rheumatol. 2007 Feb;34(2):374-9
references: 17183618
references: Autoimmun Rev. 2008 Jan;7(3):204-8
references: 18190879
references: J Periodontol. 2013 Apr;84(4):477-85
references: 22631882
references: Arch Dermatol. 2009 Apr;145(4):379-82
references: 19380659
references: J Dent Res. 2006 Aug;85(8):678-89
references: 16861283
references: J Public Health Dent. 2002 Spring;62(2):115-21
references: 11989206
references: J Periodontol. 2007 Jul;78(7 Suppl):1439-54
references: 17610398
references: Exp Dermatol. 2007 Oct;16(10):779-98
references: 17845210
references: Ann Epidemiol. 1992 May;2(3):231-9
references: 1342273
references: Dent Res J (Isfahan). 2010 Summer;7(2):45-50
references: 22013456
references: J Periodontol. 1992 Oct;63(10):854-7
references: 1403594
references: J Clin Periodontol. 2000 Nov;27(11):810-8
references: 11073323
references: Int J Dent Hyg. 2007 May;5(2):82-6
references: 17461959
references: J Am Acad Dermatol. 2008 Jul;59(1):113-21
references: 18436339
references: J Periodontol. 2005 Nov;76(11 Suppl):2106-15
references: 16277583
references: Arch Intern Med. 2007 Aug 13-27;167(15):1670-5
references: 17698691
references: Periodontol 2000. 2010 Jun;53:111-23
references: 20403108
references: Arch Dermatol. 1992 Jan;128(1):39-42
references: 1739285
references: Dermatol Ther. 2010 Mar-Apr;23(2):114-8
references: 20415817
references: Clin Exp Dermatol. 2001 Jun;26(4):314-20
references: 11422182
references: JAMA. 2006 Oct 11;296(14):1735-41
references: 17032986
references: Int J Dermatol. 2006 Dec;45(12):1420-2
references: 17184243
references: J Periodontol. 1999 Jan;70(1):13-29
references: 10052767
references: Periodontol 2000. 2007;43:41-55
references: 17214834
references: J Dent Res. 2005 Oct;84(10):881-90
references: 16183785
references: Br J Dermatol. 2000 Oct;143(4):815-20
references: 11069462
references: Arch Dermatol. 2010 Dec;146(12):1364-9
references: 20713772
references: J Public Health Dent. 2002 Spring;62(2):122-8
references: 11989207