title: No-carrier-added [18F]fluoroarenes from the radiofluorination of diaryl sulfoxides.
abstract: No-carrier-added [(18)F]fluoroarenes were synthesized through the radiofluorination of diaryl sulfoxides with [(18)F]fluoride ion. Diaryl sulfoxides bearing a para electron-withdrawing substituent readily gave the corresponding 4-[(18)F]fluoroarenes in high RCYs. This process broadens the scope for preparing novel (18)F-labeling synthons and PET radiotracers.
authors: Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, MD 20892-1003, USA.
authors: Joong-Hyun
authors: JH
authors: Chun
authors: Cheryl L
authors: CL
authors: Morse
authors: Frederick T
authors: FT
authors: Chin
authors: Victor W
authors: VW
authors: Pike
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry; D054879:Halogenation; D049268:Positron-Emission Tomography; D013454:Sulfoxides / Q000737:chemistry*
chemical_list: D005462:Fluorine Radioisotopes; D013454:Sulfoxides
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