title: A rapid and sensitive method for the detection of aromatic amines in cosmetics.
abstract: Aromatic amines (AAs) are common chemical pollutants and banned ingredients in cosmetics. In this study, a rapid, simple and stable method for the detection of nine AAs in cosmetics was established based on the optimization of cation exchange solid-phase extraction and liquid chromatography tandem mass spectrometry. The method displayed good linearity within a range of 2-1,000 µg/kg, with limits of quantitation at the level of µg/kg for cosmetic samples. The recoveries obtained for all analyzed amines ranged between 83.6 and 97.8%, and the repeatability (r) and reproducibility (R) values indicated that all nine AAs showed good precision (r ≤ 4.5% and R ≤ 7.7%). The method was applied for the detection of 36 cosmetic samples. It was found that the primary pollutants of AAs were 3, 3'-dichlorobenzidine and 4-aminoazobenzene. The total amine concentration in cosmetic samples ranged from 880 to 5,200 µg/kg. The proposed method is applicable for the analysis of most cosmetic samples.
authors: 1Hangzhou Institute of Calibration and Testing for Quality and Technical Supervision, Hangzhou 310004, P. R. China.
authors: Xiao
authors: X
authors: Hailong
authors: Qian
authors: Q
authors: Fen
authors: Xu
authors: X
authors: Ying
authors: Pan
authors: P
authors: Jianhong
authors: Tu
authors: T
authors: Haiyun
authors: Wang
authors: W
authors: Hongqing
authors: Lin
authors: L
authors: Saijun
authors: Han
authors: H
authors: Jichun
mesh_terms: D000588:Amines / Q000032:analysis*; D001555:Benzene Derivatives / Q000032:analysis*; D003358:Cosmetics / Q000737:chemistry*; D016014:Linear Models; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000588:Amines; D001555:Benzene Derivatives; D003358:Cosmetics