title: Medication use in breast cancer survivors compared to midlife women.
abstract: OBJECTIVE
  Many breast cancer survivors (BCS) take multiple medications for health problems associated with the treated cancer and other noncancer comorbidities. However, there is no published, large-scale descriptive evaluation of medication use in BCS compared to midlife women. The purpose of this study was (1) to compare the number and types of prescription medications and over-the-counter medications between BCS and midlife women without cancer and (2) to assess possible drug-drug interactions by evaluating the cytochrome P450 isoform properties of medications (inductors and inhibitors) in both groups.
  
  
  METHODS
  A cross-sectional, descriptive, comparative design was used. Baseline data from 98 BCS and 138 midlife women without cancer was analyzed from a behavioral intervention trial for menopausal symptoms.
  
  
  RESULTS
  BCS were taking significantly more prescription medications and a larger variety of different types of medication classifications (p < 0.05) after controlling for group differences (race, noncancer comorbid conditions, marital status, income, and smoking) in demographics. Twenty-four women were taking at least one medication considered to be a cytochrome P450 isoforms (CYP) inhibitor or inducer capable of clinical drug-drug interactions with no differences in CYP inhibitors or inducers found between groups.
  
  
  CONCLUSIONS
  BCS are taking a vast array of medications during survivorship. It is unclear if prescription medications are managed by a single healthcare provider or several providers. Clinical implications are to monitor for possible interactions among the various prescription medications, over-the-counter medications, and supplements. Implications for behavioral and biomedical research are that clinical studies need to carefully assess and account for multiple medication uses. RELEVANCE OF THE STUDY: The findings of this study are relevant to research and practice for both oncology and general practitioners. The importance of assessing medication information provides information about symptom management in individuals surviving cancer. In addition, the potential interaction of drugs impacts efficacy of various treatments and impacts compliance by patients.
authors: Indiana University School of Nursing, 1111 Middle Drive NU W401, Indianapolis, IN 46202, USA. Jlelam@iupui.edu
authors: Julie L
authors: JL
authors: Otte
authors: Todd C
authors: TC
authors: Skaar
authors: Jingwei
authors: J
authors: Wu
authors: Menggang
authors: M
authors: Yu
authors: Kristin
authors: K
authors: Ryker
authors: Debra S
authors: DS
authors: Burns
authors: Janet S
authors: JS
authors: Carpenter
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms; D015897:Comorbidity; D019587:Dietary Supplements; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000008:administration & dosage*; D010349:Patient Compliance; D055553:Prescription Drugs / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D017741:Survivors
chemical_list: D004366:Nonprescription Drugs; D055553:Prescription Drugs
references: Pharmacogenomics J. 2003;3(1):3-5
references: 12629575
references: J Cancer Surviv. 2008 Sep;2(3):138-48
references: 18792788
references: Cancer Nurs. 2012 May-Jun;35(3):195-202
references: 21946903
references: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references: 21296855
references: Clin Pharmacol Ther. 2011 Mar;89(3):379-86
references: 21248726
references: Psychooncology. 2011 Mar;20(3):321-5
references: 20878849
references: Pharmacogenetics. 2003 Jan;13(1):3-5
references: 12544507
references: Breast Cancer Res Treat. 2011 Jul;128(2):473-82
references: 21221774
references: Oncol Nurs Forum. 2008 Jan;35(1):57-63
references: 18192153
references: J Palliat Med. 2011 May;14(5):563-6
references: 21388255
references: Breast Cancer Res Treat. 2012 Jul;134(2):459-78
references: 22689091
references: J Clin Oncol. 2012 Mar 20;30(9):936-42
references: 22331951
references: Pharmacogenomics J. 2004;4(3):143-53
references: 15024382
references: J Pain Symptom Manage. 2010 Mar;39(3):535-47
references: 20083371
references: J Clin Oncol. 2008 Feb 1;26(4):665-73
references: 18235127
references: Orthop Nurs. 1999 Sep-Oct;18(5):11-8; quiz 19-20
references: 11052048