title: Clinical determinants of health-related quality of life in Mexican patients with Parkinson's disease.
abstract: OBJECTIVE
  Parkinson's disease (PD) is the second most common chronic neurodegenerative disorder. PD is clinically characterized by a constellation of motor and nonmotor symptoms that may have a direct effect on daily activities as well as in the quality of life of the patient. Identifying the symptoms more closely associated with a poor quality of life is central on improving the medical care of the patient. We undertook this study to identify and describe the clinical and demographic factors that predict health-related quality of life among Mexican patients with PD.
  
  
  METHODS
  One hundred seventy-seven patients with Parkinson's disease were included. Patients were evaluated using the following clinimetric instruments: motor subscale of the Unified Parkinson's disease rating scale, Hoehn and Yahr stage, Non-motor Symptoms Questionnaire, Parkinson's disease Questionnaire (PDQ-39) and the Mini Mental Status Examination.
  
  
  RESULTS
  Multivariate analysis showed that the main factors associated with a poor quality of life were motor impairment (β = 0.27, p <0.001) and the number of nonmotor symptoms (β = 2.17, p <0.001). The main nonmotor domains impacting on the quality of life were depression/anxiety (β = 6.36, p <0.001), cardiovascular (β = 5.39, p = 0.001), memory (β = 4.64, p <0.001) and miscellaneous (β = 3.15, p = 0.001).
  
  
  CONCLUSIONS
  Both motor and mainly nonmotor symptoms are negatively associated with health-related quality of life in patients with PD and should be appropriately attended in order to improve patient care.
authors: Movement Disorders Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico. mrodriguez@innn.edu.mx
authors: Mayela
authors: M
authors: Rodríguez-Violante
authors: Amin
authors: A
authors: Cervantes-Arriaga
authors: Teresa
authors: T
authors: Corona
authors: Daniel
authors: D
authors: Martínez-Ramírez
authors: Hugo
authors: H
authors: Morales-Briceño
authors: Pablo
authors: P
authors: Martínez-Martín
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires