title: Central leucine sensing in the control of energy homeostasis.
abstract: This article reviews recent studies identifying two key brain regions as two critical nodes in the neural network where central leucine sensing contributes to whole body energy homeostasis: the mediobasal hypothalamus and the dorsal vagal complex of the caudal brainstem. Activation of these leucine sensing sites engages multiple determinants of energy balance, including glucose homeostasis, food intake, and adiposity.
authors: Department of Medicine, Diabetes Research and Training Center, Bronx, NY 10461, USA. gary.schwartz@einstein.yu.edu
authors: Gary J
authors: GJ
authors: Schwartz
mesh_terms: D001933:Brain Stem / Q000378:metabolism*; D004734:Energy Metabolism; D006706:Homeostasis / Q000502:physiology; D007033:Hypothalamus, Middle / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D007930:Leucine
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