title: [Determination of bisphenol diglycidyl ether residues in canned foodstuffs by high performance liquid chromatography--tandem mass spectrometry].
abstract: An accurate quantitative determination and confirmative method for bisphenol diglycidyl ether residues, bisphenol A diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE), bisphenol A (2,3-dihydroxypropyl) glycidyl ether (BADGE H2O), bisphenol A bis (2,3-dihydroxypropyl) ether (BADGE x 2H2O), bisphenol A (3-chloro-2-hydroxy propyl) (2,3-dihydroxypropyl) ether (BADGE x H2O x HCl), bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether (BADGE x HCl), bisphenol A bis(3-chloro-2-hydroxypropyl) ether (BADGE x 2HCl), bisphenol F bis (2, 3-dihydroxypropyl) ether (BFDGE x 2H2O), bisphenol F bis (3-chloro-2-hydroxypropyl) ether (BFDGE x 2HCl) in canned foodstuffs by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) has been established. The sample was extracted with tert-butylmethyl ether and the extract was cleaned-up and concentrated on a Waters Oasis HLB column. The target compounds were analyzed by HPLC-MS/MS on a C18 column by the gradient elution with methanol and 5 mmol/L ammonium acetate containing 0.1% formic acid in a multiple reaction monitoring (MRM) scan mode. External matrix standard solutions were used for the quantitative determination and the calibration curves showed good linearity in the concentration range of 10.0 -2 000.0 microg/L for the nine target compounds. The limits of quantification of the nine compounds were 10.0 microg/kg (S/N > or = 10). The average recoveries of the nine compounds ranged from 79.6% to 100.9% at the spiked levels of 10.0, 100.0, 1 000.0 microg/kg with the relative standard deviations (RSDs) of 6.3%-12.1%. The method is sensitive, accurate, and suitable for the rapid determination of bisphenol diglycidyl ether residues in canned foodstuffs.
authors: Hubei Entry-Exit Inspection and Quarantine Bureau, Wuhan 430050, China. zhaoxy@hbciq.gov.cn
authors: Xiaoya
authors: X
authors: Zhao
authors: Xiaofang
authors: X
authors: Fu
authors: Peng
authors: P
authors: Wang
authors: Jing
authors: J
authors: Li
authors: Xiaozhong
authors: X
authors: Hu
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004852:Epoxy Compounds / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D057141:Food, Preserved / Q000032:analysis*; D008460:Meat / Q000032:analysis; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D001559:Benzhydryl Compounds; D004852:Epoxy Compounds; C423722:bisphenol F diglycidyl ether