title: [In vitro dissolution of forsythin in Forsythia suspensa powder of different particle diameter].
abstract: OBJECTIVE
  To examine the in vitro dissolution of forsythin in Forsythia suspensa powder of different particle diameter, in order to give guidance to the grinding process.
  
  
  METHODS
  HPLC was used to determine the in vitro dissolution quantity and dissolution velocity of forsythin coarse powder, fine powder and ultramicroscopic powder.
  
  
  RESULTS
  The dissolution curves of Forsythia suspensa coarse powder, fine powder and ultramicroscopic powder were basically inconformity to Weibull distribution. Specifically, T50 was 11.8, 10.5 and 6.8 min, respectively, and Q45 was 78.22%, 81.91% and 90.76%, respectively.
  
  
  CONCLUSIONS
  The superfine milling process can significantly increase the dissolution quantity and dissolution velocity of forsythin.
authors: Key Research Laboratory for Development of New Drugs, The Second Xiangya Hospital of Central South University, Changsha 410013, China. liuxingi128@126.com
authors: Xin-Yi
authors: XY
authors: Liu
authors: Shui-Han
authors: SH
authors: Zhang
authors: Jian-He
authors: JH
authors: Li
authors: Da-Xiong
authors: DX
authors: Xiang
authors: Li-Dan
authors: LD
authors: Yi
authors: Zu-Guang
authors: ZG
authors: Ye
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D031657:Forsythia / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D010316:Particle Size; D011208:Powders
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D005663:Furans; D011208:Powders; C423337:forsythenin