title: Access to organometallic arylcobaltcorrins through radical synthesis: 4-ethylphenylcobalamin, a potential "antivitamin B(12)".
abstract: Locked B(12): 4-Ethylphenylcobalamin, a novel organometallic arylcobalamin, has been synthesized in a radical reaction. This vitamin B(12) antimetabolite features a strong Co-C bond, and represents a "locked" form of vitamin B(12) . It may be used in animal studies to induce functional vitamin B(12) deficiency artificially to help clarify still controversial issues related to the pathophysiology of vitamin B(12) deficiency.
authors: Institute of Organic Chemistry and Centre of Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
authors: Markus
authors: M
authors: Ruetz
authors: Carmen
authors: C
authors: Gherasim
authors: Karl
authors: K
authors: Gruber
authors: Sergey
authors: S
authors: Fedosov
authors: Ruma
authors: R
authors: Banerjee
authors: Bernhard
authors: B
authors: Kräutler
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C000588543:4-ethylphenylcobalamin; D009942:Organometallic Compounds; C043960:aquacobalamin; D014805:Vitamin B 12
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