title: Treadmill exercise and wheel exercise enhance expressions of neutrophic factors in the hippocampus of lipopolysaccharide-injected rats.
abstract: Brain inflammation plays a pivotal role in the pathogenesis of chronic neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. We investigated the effects of treadmill exercise and wheel exercise on spatial learning ability in relation with long-term potentiation (LTP) using lipopolysaccharide-induced brain inflammation in the rats. Brain inflammation was induced by an injection of LPS into the cerebral ventricle. We found that brain inflammation impaired spatial learning ability and suppressed the induction of LTP in the hippocampus, as well as weakening expressions of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (Trk-B) with the phosphorylated cyclic AMP response element binding protein (p-CREB). Both treadmill exercise and wheel exercise significantly improved spatial learning ability deteriorated by brain inflammation. These effects can be ascribed to the long-lasting effect of exercise on LTP through enhancement of the expressions regarding BDNF, TrkB, and p-CREB. Treadmill exercise and wheel exercise exerted similar effects on these factors. We infer that exercise may alleviate brain inflammation-induced learning impairment.
authors: Department of Physiology, College of Medicine, Kyung Hee University, Dongdaemoon-gu, Seoul 130-701, Republic of Korea.
authors: Sung-Eun
authors: SE
authors: Kim
authors: Il-Gyu
authors: IG
authors: Ko
authors: Mal-Soon
authors: MS
authors: Shin
authors: Chang-Ju
authors: CJ
authors: Kim
authors: Byung-Kwan
authors: BK
authors: Jin
authors: Hoon-Pyo
authors: HP
authors: Hong
authors: Yong-Seok
authors: YS
authors: Jee
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism; D007276:Injections, Intraventricular; D007858:Learning; D008070:Lipopolysaccharides / Q000494:pharmacology*; D017774:Long-Term Potentiation; D008297:Male; D018782:Maze Learning; D019599:Mossy Fibers, Hippocampal / Q000502:physiology; D009414:Nerve Growth Factors / Q000378:metabolism*; D010766:Phosphorylation; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D020813:Receptor, trkB / Q000378:metabolism
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D017362:Cyclic AMP Response Element-Binding Protein; D008070:Lipopolysaccharides; D009414:Nerve Growth Factors; D020813:Receptor, trkB