title: Synthesis and anticancer activity evaluation of N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives containing (benz)azole moiety.
abstract: A new class of novel thiazole-(benz)azole derivatives was synthesized to investigate their anticancer activity. The structure of the compounds was confirmed by IR, (1)H-NMR, and MS spectral data and elemental analyses. Anticancer effect of the compounds was evaluated against A549 and C6 tumor cell lines. MTT, analysis of DNA synthesis, acridine orange/ethidium bromide staining method and analysis of caspase-3 activation assays were performed for anticancer activity investigations. Compounds 6f and 6g, which carry 5-chloro and 5-methylbenzimidazole groups showed significant anticancer activity. Potential of these compounds to direct tumor cells to apoptotic pathway, which is a precondition of anticancer action, was also observed.
authors: Department of Pharmaceutical Chemistry .
authors: Leyla
authors: L
authors: Yurttaş
authors: Yusuf
authors: Y
authors: Özkay
authors: Gülşen
authors: G
authors: Akalın-Çiftçi
authors: Şafak
authors: Ş
authors: Ulusoylar-Yıldırım
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001393:Azoles / Q000737:chemistry*; D001562:Benzimidazoles / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry; D001583:Benzoxazoles / Q000737:chemistry*; D053148:Caspase 3 / Q000378:metabolism; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004273:DNA, Neoplasm / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D006801:Humans; D015394:Molecular Structure; D051381:Rats
chemical_list: D000081:Acetamides; D000970:Antineoplastic Agents; D001393:Azoles; D001562:Benzimidazoles; D052160:Benzothiazoles; D001583:Benzoxazoles; D004273:DNA, Neoplasm; D053148:Caspase 3