title: Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease.
abstract: Five Pt(II) complexes were tested for their ability to interfere in Cu(II) or Zn(II) coordination to the Aβ peptide. Two of them induce modifications of the Cu(II) sphere but not the associated Cu(Aβ) ROS production. In contrast, they do completely preclude Zn induced Aβ aggregation.
authors: PHARMA-DEV, UMR 152 IRD-UPS, Université Paul Sabatier, 118 route de Narbonne, 31400 Toulouse, France. fabrice.collin@univ-tlse3.fr
authors: Fabrice
authors: F
authors: Collin
authors: Isabelle
authors: I
authors: Sasaki
authors: Hélène
authors: H
authors: Eury
authors: Peter
authors: P
authors: Faller
authors: Christelle
authors: C
authors: Hureau
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D052160:Benzothiazoles; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D003300:Copper / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008969:Molecular Sequence Data; D010984:Platinum / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013844:Thiazoles / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D052160:Benzothiazoles; D056831:Coordination Complexes; D013844:Thiazoles; C009462:thioflavin T; D010984:Platinum; D003300:Copper; D015032:Zinc