title: [Cerebral phaeohyphomycosis: description of a case and review of the literature].
abstract: Cerebral phaeohyphomycosis is a rare invasive fungal infection with very few cases referenced in the literature. There is no standardized treatment, and it is associated with poor outcomes. Cladophialophora bantiana, a fungus with special tropism for the central nervous system, is one of the causal agents of phaeohyphomycosis. The case presented here deals with a brain abscess by C. bantiana in an adult with Crohn's disease had beed being treated with immunosuppressive drugs. Despite the correct etiological diagnosis, surgical and pharmacological treatments, the patient died 32 days after surgery. A description of the case is followed by a review of all cerebral C. bantiana phaeohyphomycosis cases published in the last 10 years. Regardless of the use of advanced new imaging techniques in the diagnosis and treatment with new antifungal agents, cerebral phaeohyphomycosis by C. bantiana continues to have very poor prognosis. While new more successful therapeutic treatments appear, a combined surgical and pharmacological approach seems to be more appropriate for this severe mycosis.
authors: Servicio de Microbiología, Hospital Universitario y Politécnico La Fe, Valencia, España. Electronic address: frasquet_juaart@gva.es.
authors: Juan S
authors: JS
authors: Frasquet-Artés
authors: Servicio de Microbiología, Hospital Universitario y Politécnico La Fe, Valencia, España.
authors: Javier
authors: J
authors: Pemán
authors: Unidad de Enfermedades Infecciosas, Hospital Universitario y Politécnico La Fe, Valencia, España.
authors: Marino
authors: M
authors: Blanes
authors: Servicio de Microbiología, Hospital Universitario y Politécnico La Fe, Valencia, España.
authors: Miriam
authors: M
authors: Hernández-Porto
authors: Unidad de Microbiología, Departamento de Ciencias Médicas Básicas, Instituto de Investigación Sanitaria Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Tarragona, España.
authors: Josep
authors: J
authors: Cano
authors: Servicio de Anatomía Patológica, Hospital Universitario y Politécnico La Fe, Valencia, España.
authors: Enrique
authors: E
authors: Jiménez-Herrero
authors: Servicio de Microbiología, Hospital Universitario y Politécnico La Fe, Valencia, España.
authors: José Luis
authors: JL
authors: López-Hontangas
mesh_terms: D000368:Aged; D001922:Brain Abscess / Q000175:diagnosis / Q000382:microbiology*; D060425:Cerebral Phaeohyphomycosis / Q000175:diagnosis; D017809:Fatal Outcome; D006801:Humans; D008297:Male
keywords: Absceso cerebral; Cerebral abscess; Cladophialophora bantiana; Feohifomicosis; Phaeohyphomycosis