title: A Gd-doped Mg-Al-LDH/Au nanocomposite for CT/MR bimodal imagings and simultaneous drug delivery.
abstract: The early diagnosis and simultaneous drug delivery monitored by non-invasive visualization are highly challenging but clinical-relevant for the diagnostics and therapy monitoring of serious diseases such as cancers. Herein, a Gd-doped layered double hydroxide (LDH)/Au nanocomposite has been developed as both a drug carrier and a diagnostic agent. The obtained nanocomposite shows high non-anionic anti-cancer drug DOX loading capacity and an interesting pH-responsive release profile of loaded DOX. The nanocomposite was found to be able to efficiently transport DOX into the cancer cell, release the DOX in the acidic cytoplasm and then cause death of cancer cells. Meanwhile, the nanocomposite demonstrates better in vitro CT and T(1)-weighted MR imaging capabilities than the commercial MRI and CT contrast agents and favorable in vivo CT and T(1)-weighted MR imaging performance. After being modified with heparin, the nanocomposite also demonstrates effective CT and MR imagings of tumors by intravenous administration in tumor-bearing mice. Furthermore, the nanocomposite shows negligible cytotoxicity and no detectable tissue damage on mice after injection of high dosage of nanocomposite. In conclusion, the synthetic nanocomposite is expected to be a potential theranostic agent for bimodal imagings of cancers and anti-cancer drug delivery as well.
authors: State Key Laboratory of High performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai 200050, PR China.
authors: Lijun
authors: L
authors: Wang
authors: Huaiyong
authors: H
authors: Xing
authors: Shengjian
authors: S
authors: Zhang
authors: Qingguo
authors: Q
authors: Ren
authors: Limin
authors: L
authors: Pan
authors: Kun
authors: K
authors: Zhang
authors: Wenbo
authors: W
authors: Bu
authors: Xiangpeng
authors: X
authors: Zheng
authors: Liangping
authors: L
authors: Zhou
authors: Weijun
authors: W
authors: Peng
authors: Yanqing
authors: Y
authors: Hua
authors: Jianlin
authors: J
authors: Shi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D003287:Contrast Media; D016503:Drug Delivery Systems; D005682:Gadolinium; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides / Q000737:chemistry; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D006878:Hydroxides; D006046:Gold; D005682:Gadolinium