title: Epigenetic mechanisms in migraine: a promising avenue?
abstract: Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will focus on evidence that epigenetic mechanisms play an important role in disease etiology. Epigenetics comprise both DNA methylation and post-translational modifications of the tails of histone proteins, affecting chromatin structure and gene expression. Besides playing a role in establishing cellular and developmental stage-specific regulation of gene expression, epigenetic processes are also important for programming lasting cellular responses to environmental signals. Epigenetic mechanisms may explain how non-genetic endogenous and exogenous factors such as female sex hormones, stress hormones and inflammation trigger may modulate attack frequency. Developing drugs that specifically target epigenetic mechanisms may open up exciting new avenues for the prophylactic treatment of migraine.
authors: Department of Human Genetics, Leiden University Medical Centre, Einthovenweg 20, Leiden 2333 ZC, The Netherlands.
authors: Else
authors: E
authors: Eising
authors: Nicole
authors: N
authors: A Datson
authors: Arn M J M
authors: AM
authors: van den Maagdenberg
authors: Michel D
authors: MD
authors: Ferrari
mesh_terms: D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D008881:Migraine Disorders / Q000209:etiology* / Q000503:physiopathology*
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