title: Comparison of galactomannan enzyme immunoassay performance levels when testing serum and plasma samples.
abstract: Diagnostic galactomannan (GM) enzyme immunoassay (EIA) testing is formally validated only for serum, though in practice, plasma is occasionally tested. It is assumed, but not confirmed, that results will be comparable to those for serum. GM EIA when testing plasma was evaluated, providing sensitivity (85.7%) and specificity (85.4%) comparable to those for serum. Plasma index values were higher than those for serum; if plasma GM EIA were used to define probable cases, four additional cases would have been diagnosed.
authors: Public Health Wales, Microbiology Cardiff, University Hospital of Wales (UHW), Cardiff, United Kingdom. lewis.white@wales.nhs.uk
authors: P Lewis
authors: PL
authors: White
authors: Tim
authors: T
authors: Jones
authors: Katie
authors: K
authors: Whittle
authors: Joanne
authors: J
authors: Watkins
authors: Rosemary A
authors: RA
authors: Barnes
mesh_terms: D000946:Antigens, Fungal / Q000097:blood*; D001228:Aspergillosis / Q000175:diagnosis*; D019411:Clinical Laboratory Techniques / Q000379:methods*; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D008351:Mannans / Q000097:blood*; D010949:Plasma / Q000737:chemistry*; D012680:Sensitivity and Specificity; D044967:Serum / Q000737:chemistry*
chemical_list: D000946:Antigens, Fungal; D008351:Mannans; C012990:galactomannan; D005690:Galactose
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