title: Association between age and high-risk human papilloma virus in Mexican oral cancer patients.
abstract: OBJECTIVE
  Studies reporting low prevalence of HPV in OSCC with declining age at presentation are increasing. The aim of this study was to determine the prevalence of HPV in a group of OSCC cases and controls in a Mexican population.
  
  
  METHODS
  The matched case-control study included 80 OSCC cases and 320 controls. HPV/DNA presence was evaluated through PCR amplification using three sets of consensus primers for the L1 gene. A conditional logistic regression analysis was carried out for the matched OSCC cases and controls. Interactions between risk factors and OCSS were tested in the construction process of the models.
  
  
  RESULTS
  HPV prevalence was 5% in OSCC cases and 2.5% in controls. HPV-detected types were 16, 18 and 56. According to conditional logistics regression model, an association was detected between HR-HPV and OSCC. All HR-HPV-positive OSCC cases corresponded to young patients (<45 years), non-smokers and non-alcohol drinkers.
  
  
  CONCLUSIONS
  The HR-HPV can be a contributing factor to oral carcinogenesis, especially in younger individuals without known risk factors such as tobacco and alcohol.
authors: Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico City, Mexico.
authors: I
authors: I
authors: González-Ramírez
authors: M E
authors: ME
authors: Irigoyen-Camacho
authors: V
authors: V
authors: Ramírez-Amador
authors: M
authors: M
authors: Lizano-Soberón
authors: A
authors: A
authors: Carrillo-García
authors: A
authors: A
authors: García-Carrancá
authors: Y
authors: Y
authors: Sánchez-Pérez
authors: R
authors: R
authors: Méndez-Martínez
authors: M
authors: M
authors: Granados-García
authors: Lm
authors: L
authors: Ruíz-Godoy
authors: Cm
authors: C
authors: García-Cuellar
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000821:virology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology* / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications*; D015995:Prevalence; D012307:Risk Factors
keywords: human papillomavirus; oral squamous cell carcinoma; young patients