title: PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors.
abstract: BACKGROUND
  Genetic factors are important in the development of posttraumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder remain largely unresolved. The present study investigated the association between ADCYAP1R1 rs2267735 genotype and PTSD symptoms in a highly traumatized sample of Chinese adults.
  
  
  METHODS
  Participants included 326 victims who experienced 2008 Wenchuan earthquake and lost their children during the disaster. PTSD symptoms were assessed with the PTSD Checklist (PCL). The ADCYAP1R1 rs2267735 SNP was genotyped with the Sequenom iPlex chemistries and the MassARRAY system.
  
  
  RESULTS
  The results indicated that although the rs2267735 'CC' genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's emotional numbing symptoms in women.
  
  
  CONCLUSIONS
  A relatively small sample exposed to specific traumatic events was used, and PTSD was assessed using a self-reported instrument.
  
  
  CONCLUSIONS
  The findings suggest that the PACAP-PAC1 receptor pathway may play an important role in female human responses to traumatic stress, and carry implications for better understanding and treating of posttraumatic psychopathology.
authors: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. wangli1@psych.ac.cn
authors: Li
authors: L
authors: Wang
authors: Chengqi
authors: C
authors: Cao
authors: Richu
authors: R
authors: Wang
authors: Yulan
authors: Y
authors: Qing
authors: Jianxin
authors: J
authors: Zhang
authors: Xiang Yang
authors: XY
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001601:Bereavement; D002681:China; D004190:Disasters; D055866:Earthquakes; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010290:Parents / Q000523:psychology*; D020641:Polymorphism, Single Nucleotide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I / Q000235:genetics*; D012720:Severity of Illness Index; D012737:Sex Factors; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics* / Q000523:psychology*; D017741:Survivors / Q000523:psychology* / Q000706:statistics & numerical data
chemical_list: D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
keywords: Association study; PAC1 receptor; PTSD; Single-nucleotide polymorphism