title: Pathogenesis of accelerated fibrosis in HIV/HCV co-infection.
abstract: Human immunodeficiency virus (HIV) infection is a major cause of acceleration of hepatitis C virus-related liver disease, cirrhosis, and death. However, studies of liver disease pathogenesis in HIV/HCV coinfection have thus far been limited. Emerging data support multiple derangements attending HIV coinfection, including increases in profibrogenic cytokine expression and secretion, generation of enhanced oxidative stress, and increases in hepaotcyte apoptosis. These derangements may be further augmented in the presence of increased microbial translocation in the setting of HIV disease. New insight into the mechanisms of HIV/HCV pathogenesis causing accelerated liver fibrosis could lead to new therapeutic strategies designed to retard ths process.
authors: Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors: Wenyu
authors: W
authors: Lin
authors: Ethan M
authors: EM
authors: Weinberg
authors: Raymond T
authors: RT
authors: Chung
mesh_terms: D017209:Apoptosis; D018988:Bacterial Translocation; D060085:Coinfection / Q000473:pathology*; D016207:Cytokines / Q000378:metabolism; D015658:HIV Infections / Q000150:complications* / Q000473:pathology*; D006526:Hepatitis C / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology*; D018384:Oxidative Stress
chemical_list: D016207:Cytokines
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