title: Love and death: microglia, NLRP3 and the Alzheimer's brain.
abstract: Microglia were previously attributed to be vital brain guardians for neuronal survival and synaptic pruning during development as well as for the brain's fight against environmental pathogens. A new report in Nature by the Heneka, Latz and Golenbock groups, however, sheds new light on these distinct myeloid cells by revealing their deadly nature for mature neurons during neurodegeneration.
authors: Institute of Neuropathology, University of Freiburg, Freiburg, Germany.
authors: Tobias
authors: T
authors: Goldmann
authors: Tuan Leng
authors: TL
authors: Tay
authors: Marco
authors: M
authors: Prinz
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D020170:Caspase 1 / Q000378:metabolism; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism; D051379:Mice; D017628:Microglia / Q000166:cytology / Q000378:metabolism*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D053763:Presenilins / Q000235:genetics / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D002352:Carrier Proteins; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D053763:Presenilins; D020170:Caspase 1
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