title: Genomics and proteomics approaches for biomarker discovery in sporadic colorectal cancer with metastasis.
abstract: Sporadic colorectal cancer (sCRC) is one of the most frequent types of cancer in Europe. Despite understanding of its tumorigenesis, the metastatic process is not yet clear. In this article, we review the most significant genetic and proteomic advances that have been made in regards to research of the sCRC metastatic process, and the new biomarkers that are able to predict disease prognosis or response to treatments, in order to define personalized medicine.
authors: Servicio General de Citometría, Departamento de Medicina and Centro de Investigación del Cáncer, Salamanca, Spain.
authors: María
authors: M
authors: González-González
authors: Jacinto Garcia
authors: JG
authors: Garcia
authors: José Antonio Alcazar
authors: JA
authors: Montero
authors: Luis Miguel González
authors: LM
authors: Fernandez
authors: Oscar
authors: O
authors: Bengoechea
authors: Oscar Blanco
authors: OB
authors: Muñez
authors: Alberto
authors: A
authors: Orfao
authors: J M
authors: JM
authors: Sayagues
authors: Manuel
authors: M
authors: Fuentes
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D002869:Chromosome Aberrations; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D020411:Oligonucleotide Array Sequence Analysis; D010449:Peptide Mapping; D011379:Prognosis; D040081:Protein Array Analysis; D020543:Proteome / Q000235:genetics / Q000378:metabolism*; D040901:Proteomics
chemical_list: D014408:Biomarkers, Tumor; D020543:Proteome