title: EEG microstates associated with salience and frontoparietal networks in frontotemporal dementia, schizophrenia and Alzheimer's disease.
abstract: OBJECTIVE
  There are relevant links between resting-state fMRI networks, EEG microstate classes and psychopathological alterations in mental disorders associated with frontal lobe dysfunction. We hypothesized that a certain microstate class, labeled C and correlated with the salience network, was impaired early in frontotemporal dementia (FTD), and that microstate class D, correlated with the frontoparietal network, was impaired in schizophrenia.
  
  
  METHODS
  We measured resting EEG microstate parameters in patients with mild FTD (n = 18), schizophrenia (n = 20), mild Alzheimer's disease (AD; n = 19) and age-matched controls (old n = 19, young n = 18) to investigate neuronal dynamics at the whole-brain level.
  
  
  RESULTS
  The duration of class C was significantly shorter in FTD than in controls and AD, and the duration of class D was significantly shorter in schizophrenia than in controls, FTD and AD. Transition analysis showed a reversed sequence of activation of classes C and D in FTD and schizophrenia patients compared with that in controls, with controls preferring transitions from C to D, and patients preferring D to C.
  
  
  CONCLUSIONS
  The duration and sequence of EEG microstates reflect specific aberrations of frontal lobe functions in FTD and schizophrenia.
  
  
  CONCLUSIONS
  This study highlights the importance of subsecond brain dynamics for understanding of psychiatric disorders.
authors: Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. keiichironishida219@gmail.com
authors: Keiichiro
authors: K
authors: Nishida
authors: Yosuke
authors: Y
authors: Morishima
authors: Masafumi
authors: M
authors: Yoshimura
authors: Toshiaki
authors: T
authors: Isotani
authors: Satoshi
authors: S
authors: Irisawa
authors: Kay
authors: K
authors: Jann
authors: Thomas
authors: T
authors: Dierks
authors: Werner
authors: W
authors: Strik
authors: Toshihiko
authors: T
authors: Kinoshita
authors: Thomas
authors: T
authors: Koenig
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D001931:Brain Mapping; D004569:Electroencephalography; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D057180:Frontotemporal Dementia / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D006212:Hallucinations / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D015899:Tomography, Emission-Computed, Single-Photon; D055815:Young Adult