title: Uniform ultrasmall graphene oxide nanosheets with low cytotoxicity and high cellular uptake.
abstract: Graphene oxide (GO) is an increasingly important nanomaterial, which exhibits great promise in the area of bionanotechnology and nanobiomedicine. In this study, we synthesized uniform ultrasmall graphene oxide nanosheets with high yield by a convenient way of modified Hummers' method. The uniform ultrasmall GO nanosheets, which exhibit fluorescence property and outstanding stability in a wide range of pH values, were less than 50 nm. Furthermore, because of the advantages of its lateral size, the uniform ultrasmall GO nanosheets showed excellent biocompatibility of lower cytotoxicity and higher cellular uptake amount compared to the random large GO nanosheets. Therefore, the as-prepared uniform ultrasmall GO nanosheets could be explored as the ideal nanocarriers for drug delivery and intracellular fluorescent nanoprobe.
authors: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
authors: Huan
authors: H
authors: Zhang
authors: Cheng
authors: C
authors: Peng
authors: Jianzhong
authors: J
authors: Yang
authors: Min
authors: M
authors: Lv
authors: Rui
authors: R
authors: Liu
authors: Dannong
authors: D
authors: He
authors: Chunhai
authors: C
authors: Fan
authors: Qing
authors: Q
authors: Huang
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D016503:Drug Delivery Systems / Q000295:instrumentation*; D006108:Graphite / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D006367:HeLa Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D010087:Oxides; D006108:Graphite