title: The role of telomeres in stem cells and cancer.
abstract: Telomere shortening impairs proliferation of transformed cells but also leads to cancer initiation by inducing chromosomal instability. Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis.
authors: Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany.
authors: Cagatay
authors: C
authors: Günes
authors: K Lenhard
authors: KL
authors: Rudolph
mesh_terms: D000818:Animals; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D013234:Stem Cells / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism*