title: Results from a randomized trial of a web-based, tailored decision aid for women at high risk for breast cancer.
abstract: OBJECTIVE
  To assess the impact of Guide to Decide (GtD), a web-based, personally-tailored decision aid designed to inform women's decisions about prophylactic tamoxifen and raloxifene use.
  
  
  METHODS
  Postmenopausal women, age 46-74, with BCRAT 5-year risk ≥ 1.66% and no prior history of breast cancer were randomized to one of three study arms:intervention (n=690), Time 1 control (n=160), or 3-month control (n=162). Intervention participants viewed GtD prior to completing a post-test and 3 month follow-up assessment. Controls did not. We assessed the impact of GtD on women's decisional conflict levels and treatment decision behavior at post-test and at 3 months, respectively.
  
  
  RESULTS
  Intervention participants had significantly lower decisional conflict levels at post-test (p<0.001) and significantly higher odds of making a decision about whether or not to take prophylactic tamoxifen or raloxifene at 3-month follow-up (p<0.001) compared to control participants.
  
  
  CONCLUSIONS
  GtD lowered decisional conflict and helped women at high risk of breast cancer decide whether to take prophylactic tamoxifen or raloxifene to reduce their cancer risk.
  
  
  CONCLUSIONS
  Web-based, tailored decision aids should be used more routinely to facilitate informed medical decisions, reduce patients' decisional conflict, and empower patients to choose the treatment strategy that best reflects their own values.
authors: University of Washington, Department of Health Services, Seattle, WA, USA. banegasmp@mail.nih.gov
authors: Matthew P
authors: MP
authors: Banegas
authors: Jennifer B
authors: JB
authors: McClure
authors: William E
authors: WE
authors: Barlow
authors: Peter A
authors: PA
authors: Ubel
authors: Dylan M
authors: DM
authors: Smith
authors: Brian J
authors: BJ
authors: Zikmund-Fisher
authors: Sarah M
authors: SM
authors: Greene
authors: Angela
authors: A
authors: Fagerlin
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000517:prevention & control / Q000523:psychology*; D003220:Conflict, Psychological; D003661:Decision Support Techniques; D005260:Female; D006801:Humans; D020407:Internet; D008824:Michigan; D008875:Middle Aged; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use*; D012307:Risk Factors; D013629:Tamoxifen / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013629:Tamoxifen; D020849:Raloxifene Hydrochloride
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