title: The effects of QuikClot Combat Gauze and movement on hemorrhage control in a porcine model.
abstract: The purpose of this study was twofold: (1) to examine the effectiveness of QuikClot Combat Gauze (QCG) compared to a control group and (2) investigate the effect of movement on hemorrhage control when QCG is employed. This was a prospective, experimental design employing an established porcine model of uncontrolled hemorrhage. The minimum number of animals (n = 11 per group) was used to obtain a statistically valid result. There were no statistically significant differences between the groups (p > 0.05) indicating that the groups were equivalent on the following parameters: activating clotting time, the subject weights, core body temperatures, amount of 1 minute hemorrhage, arterial blood pressures, and the amount and percentage of total blood volume. There were significant differences in the amount of hemorrhage (p = 0.018) and the number of movements (p = 0.000) between the QCG and control. QCG is statistically and clinically superior at controlling hemorrhage compared to the standard pressure dressing control group. Furthermore, it produces a more robust clot that can withstand significant movement. In conclusion, QCG is an effective hemostatic agent for use in civilian and military trauma management.
authors: Veteran Anesthesia Services, PO Box 691286, San Antonio, TX 78269, USA.
authors: Brian
authors: B
authors: Gegel
authors: James
authors: J
authors: Burgert
authors: John
authors: J
authors: Gasko
authors: Christian
authors: C
authors: Campbell
authors: Mark
authors: M
authors: Martens
authors: Joseph
authors: J
authors: Keck
authors: Harmony
authors: H
authors: Reynolds
authors: Michael
authors: M
authors: Loughren
authors: Don
authors: D
authors: Johnson
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005263:Femoral Artery / Q000293:injuries; D005268:Femoral Vein / Q000293:injuries; D006470:Hemorrhage / Q000628:therapy*; D006490:Hemostatics / Q000008:administration & dosage*; D013552:Swine
chemical_list: D006490:Hemostatics