title: Serum Level of Vascular Endothelial Growth Factor in Patients with Different Clinical SubtypeS of Oral Lichen Planus.
abstract: BACKGROUND
  Oral lichen planus is a chronic inflammatory disease with a poorly understood etiology. The role of angiogenesis in the development of different chronic inflammatory diseases is of great concern. Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis. We aimed to evaluate the serum level of VEGF in patients with oral lichen planus compared with normal individuals and consider its clinical significance.
  
  
  METHODS
  In this case-control study, 36 serum samples from patients diagnosed with oral lichen planus admitted to the Oral Medicine Department of the School of Dentistry at Shiraz University of Medical Sciences (14 men, 22 women, mean [±SD] age: 38.8 [±6.07] years) and 23 serum samples from healthy individuals (9 men, 14 women, mean [±SD] age: 38.7 [±4.9] years) were collected. VEGF concentration was measured using the ELISA method. The Mann-Whitney test was used for statistical analysis.
  
  
  RESULTS
  The serum VEGF level was significantly higher in patients with oral lichen planus compared with the healthy controls (112.97 [±63.2] vs. 66.21 [±56.2] ngr/ml, P<0.001). A similar difference was also observed between the two types of oral lichen planus, being more pronounced in the erosive form (P<0.001).
  
  
  CONCLUSIONS
  Serum VEGF can be used as a useful and suitable marker to scrutinize the disease activity.
authors: Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran;
authors: Maryam
authors: M
authors: Mardani
authors: Jannan
authors: J
authors: Ghabanchi
authors: Mohammad Javad
authors: MJ
authors: Fattahi
authors: Azadeh Andisheh
authors: AA
authors: Tadbir
keywords: Oral lichen planus; Serum; Vascular endothelial growth factor
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