title: Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model.
abstract: Exposure to ionizing radiation (IR) elicits a set of complex biological responses involving gene expression and protein turnover that ultimately manifest as dysregulation of metabolic processes representing the cellular phenotype. Although radiation biomarkers have been reported in urine and serum, they are not informative about IR mediated tissue or organ specific injury. In the present study we report IR induced metabolic changes in gastrointestinal (GI) tissue of CD2F1 mice using ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight mass spectrometry. Post-radiation GI injury is a critical determinant of survival after exposure to IR. Our results show a distinct dose and time dependent response to GI tissue injury.
authors: Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889-5603, USA.
authors: Sanchita P
authors: SP
authors: Ghosh
authors: Rajbir
authors: R
authors: Singh
authors: Kushal
authors: K
authors: Chakraborty
authors: Shilpa
authors: S
authors: Kulkarni
authors: Arushi
authors: A
authors: Uppal
authors: Yue
authors: Y
authors: Luo
authors: Prabhjit
authors: P
authors: Kaur
authors: Rupak
authors: R
authors: Pathak
authors: K Sree
authors: KS
authors: Kumar
authors: Martin
authors: M
authors: Hauer-Jensen
authors: Amrita K
authors: AK
authors: Cheema
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D016000:Cluster Analysis; D004195:Disease Models, Animal; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000528:radiation effects*; D050356:Lipid Metabolism / Q000528:radiation effects; D008297:Male; D053858:Metabolic Networks and Pathways; D055442:Metabolome; D055432:Metabolomics; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000378:metabolism; D013997:Time Factors; D014916:Whole-Body Irradiation / Q000009:adverse effects*
chemical_list: D015415:Biomarkers
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