title: Parental psychiatric disorders and autism spectrum disorders.
abstract: The present population-based, case-control study examines associations between specific parental psychiatric disorders and autism spectrum disorders (ASD) including childhood autism, Asperger's syndrome and pervasive developmental disorder (PDD-NOS). The cohort includes 4713 children born between 1987 and 2005 with diagnoses of childhood autism, Asperger's syndrome or PDD-NOS. Cases were ascertained from the Finnish Hospital Discharge Register, and each was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Controls were selected from the Finnish Medical Birth Register. Parents were identified through the Finnish Medical Birth Register and Finnish Central Population Register. Parental psychiatric diagnoses from inpatient care were collected from the Finnish Hospital Discharge Register. Conditional logistic regression models were used to assess whether parents' psychiatric disorders predicted ASD after controlling for parents' age, smoking during pregnancy and weight for gestational age. In summary, parental schizophrenia spectrum disorders and affective disorders were associated with the risk of ASD regardless of the subgroup. PDD-NOS was associated with all parental psychiatric disorders investigated. Further studies are needed to replicate these findings. These results may facilitate the investigation of shared genetic and familial factors between ASD and other psychiatric disorders.
authors: Department of Child Psychiatry, University of Turku and Turku University Hospital, Turku, Finland. ekjoki@utu.fi
authors: Elina
authors: E
authors: Jokiranta
authors: Alan S
authors: AS
authors: Brown
authors: Markus
authors: M
authors: Heinimaa
authors: Keely
authors: K
authors: Cheslack-Postava
authors: Auli
authors: A
authors: Suominen
authors: Andre
authors: A
authors: Sourander
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D016241:Child of Impaired Parents / Q000523:psychology*; D002675:Child, Preschool; D018672:Community Health Planning; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D010290:Parents / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
references: Trends Neurosci. 2009 Feb;32(2):69-72
references: 19135727
references: Acta Paediatr. 2010 Sep;99(9):1425-8
references: 20412100
references: Duodecim. 1989;105(18):1540-6
references: 2680445
references: J Am Acad Child Adolesc Psychiatry. 2012 May;51(5):477-486.e1
references: 22525954
references: J Am Acad Child Adolesc Psychiatry. 2009 Jan;48(1):10-8
references: 19218893
references: J Neural Transm (Vienna). 2004 Jul;111(7):891-902
references: 15206005
references: Alcohol Clin Exp Res. 1992 Jun;16(3):558-65
references: 1626656
references: J Child Psychol Psychiatry. 2005 Aug;46(8):837-49
references: 16033632
references: Arch Gen Psychiatry. 2004 Aug;61(8):836-43
references: 15289282
references: J Autism Dev Disord. 2001 Feb;31(1):19-28
references: 11439750
references: J Autism Dev Disord. 2009 Jun;39(6):856-64
references: 19191016
references: Am J Ment Retard. 2006 May;111(3):155-69
references: 16597183
references: Eur Arch Psychiatry Clin Neurosci. 2000;250(6):311-9
references: 11153966
references: Nature. 2008 Oct 16;455(7215):919-23
references: 18923514
references: Pediatr Res. 2009 Jun;65(6):591-8
references: 19218885
references: Am J Epidemiol. 2005 May 15;161(10):916-25; discussion 926-8
references: 15870155
references: J Child Psychol Psychiatry. 2005 Sep;46(9):963-71
references: 16108999
references: Autism Res. 2011 Apr;4(2):143-8
references: 21480539
references: J Autism Dev Disord. 2007 Feb;37(2):243-50
references: 16897383
references: J Autism Dev Disord. 1998 Oct;28(5):369-92
references: 9813774
references: BMJ. 2009 Jan 08;338:a2981
references: 19131382
references: Am J Psychiatry. 1999 Apr;156(4):557-63
references: 10200734
references: J Epidemiol Community Health. 2009 Jun;63(6):420-5
references: 19211588
references: Epidemiology. 2002 Jul;13(4):417-23
references: 12094096
references: J Pediatr. 2012 Nov;161(5):830-6
references: 22677565
references: J Am Acad Child Adolesc Psychiatry. 2008 Aug;47(8):921-9
references: 18645422
references: J Child Psychol Psychiatry. 1989 May;30(3):405-16
references: 2745591
references: Mol Psychiatry. 2011 Dec;16(12):1203-12
references: 21116277
references: Acta Psychiatr Scand. 2001 Jun;103(6):428-34
references: 11401656
references: J Epidemiol Community Health. 2003 Jun;57(6):433-9
references: 12775790
references: J Autism Dev Disord. 2005 Jun;35(3):351-60
references: 16119476
references: Hum Mol Genet. 2001 Jul 15;10(15):1611-7
references: 11468279
references: Arch Gen Psychiatry. 2011 Nov;68(11):1095-102
references: 21727249
references: Arch Gen Psychiatry. 2011 Nov;68(11):1104-12
references: 21727247
references: Soc Psychiatry Psychiatr Epidemiol. 1997 Jul;32(5):303-8
references: 9257522
references: Psychopathology. 2007;40(3):166-71
references: 17318009
references: Eur Child Adolesc Psychiatry. 1997 Dec;6(4):181-90
references: 9442996
references: Mol Psychiatry. 2004 Nov;9(11):1037-41
references: 15197400
references: Int J Epidemiol. 2010 Aug;39(4):1074-81
references: 20371506
references: J Child Psychol Psychiatry. 1977 Sep;18(4):297-321
references: 562353
references: Am J Psychiatry. 2010 Nov;167(11):1357-63
references: 20686188
references: Nature. 2010 Jul 15;466(7304):368-72
references: 20531469
references: Soc Psychiatry Psychiatr Epidemiol. 2001 Jun;36(6):294-8
references: 11583459
references: Dev Med Child Neurol. 2002 Oct;44(10):652-9
references: 12418789
references: Am J Hum Genet. 2004 Nov;75(5):862-72
references: 15386212
references: Br J Psychiatry. 2012 Apr;200(4):282-9
references: 22241931
references: Am J Public Health. 2001 Feb;91(2):284-6
references: 11211639
references: J Am Acad Child Adolesc Psychiatry. 2004 Sep;43(9):1134-45
references: 15322417
references: J Autism Dev Disord. 2011 Aug;41(8):1090-6
references: 21082229
references: J Autism Dev Disord. 2005 Apr;35(2):177-82
references: 15909404
references: Mol Psychiatry. 2008 Feb;13(2):187-96
references: 17579608
references: Dev Med Child Neurol. 2004 Oct;46(10):652-60
references: 15473168
references: Br J Psychiatry. 1999 Sep;175:239-45
references: 10645325
references: WHO Chron. 1968 Feb;22(2):43-7
references: 5643638
references: Psychol Med. 1998 Mar;28(2):385-95
references: 9572095
references: Ment Retard Dev Disabil Res Rev. 2007;13(4):321-9
references: 17979207
references: Pediatrics. 2008 May;121(5):e1357-62
references: 18450879
references: Neurotoxicology. 2009 Sep;30(5):822-31
references: 19822263
references: Genome Med. 2009 Oct 30;1(10):102
references: 19886976
references: Psychol Med. 1995 Jan;25(1):63-77
references: 7792363
references: Alcohol Clin Exp Res. 1995 Jun;19(3):660-5
references: 7573790