title: Comparative risk of cardiac catheterisations performed on low birth weight neonates.
abstract: To determine whether cardiac catheterisation procedures for low birth weight neonatesr < or = 2.5 kg carries a greater risk of complications compared with neonates > 2.5 kg, we conducted a single-centre retrospective case–control study. From 01/03 to 01/09, 46 consecutive neonates < 2.5 kg at the time of cardiac catheterisation were identified. For each low birth weight case, three control patients > or = 2.5 kg were randomly selected from our heart centre database during the same time period. Data included demographic characteristics, type of intervention, fluoroscopy time, contrast volume, pre- and post-blood urea nitrogen to creatinine ratio, physician performing procedure, procedural risk category, and all major and minor complications. The overall incidence of complications was higher in neonates < or = 2.5 kg compared with neonates > 2.5 kg (34.8% versus 17.6%, p = 50.023) because of a greater proportion of minor complications (34.8% versus 16.9%, p = 50.021). When specific minor complications were stratified, there was a greater incidence of hypotension requiring intravenous fluids in neonates < or = 2.5 kg (6.5% versus 0%, p50.015). After controlling for physician performing procedure and risk category, neonates < or = 2.5 kg remained at a higher risk for any complication (adjusted odds ratio = 3.2, 95% confidence interval 1.4–7.2, p = 0.005). The percentage of neonates having at least one major complication was not higher in the < or = 2.5-kg group (2.2% versus 2.2%). No procedural deaths occurred in either group.
authors: Department of Pediatrics, Graduate Medical Education Office, Children's Mercy Hospital, Kansas City, Missouri 64108, USA. mmobley@cmh.edu
authors: Meghan M
authors: MM
authors: Mobley
authors: Richard E
authors: RE
authors: Stroup
authors: Stephen F
authors: SF
authors: Kaine
mesh_terms: D054087:Atrial Septum / Q000601:surgery; D063126:Balloon Valvuloplasty / Q000009:adverse effects / Q000706:statistics & numerical data*; D001806:Blood Urea Nitrogen; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D003287:Contrast Media; D003404:Creatinine / Q000097:blood; D005260:Female; D005440:Fluid Therapy / Q000706:statistics & numerical data; D005471:Fluoroscopy / Q000706:statistics & numerical data; D006801:Humans; D007022:Hypotension / Q000453:epidemiology* / Q000628:therapy; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D061646:Operative Time; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D003287:Contrast Media; D003404:Creatinine