title: Primary sclerosing cholangitis, Crohn's disease and HLA-B27 in black South African women.
abstract: Crohn's disease is rare in South African black people and primary sclerosing cholangitis (PSC) is also rare in black patients with IBD, from South Africa. The presence of HLA-B27 is generally associated with seronegative spondylo-arthropathies and correlates with the occurrence of ankylosing spondylitis, recurrent mouth ulcers and uveitis, in patients with IBD. We describe two women with the combination of Crohn's disease, PSC and HLA-B27 from our cohort of the last 5 years of three black patients with Crohn's disease. Crohn's disease, PSC and HLA-B27 respectively, occur rarely in black South Africans and their concurrent presence in two black women suggests a pathogenetic link of HLA-B27 between Crohn's disease and PSC in this population. Female gender might be an additional determinant in this setting.
authors: Department of General Surgery, Universitas Academic Hospital, University of the Free State, Bloemfontein, South Africa. ttbchl@googlemail.com
authors: O C
authors: OC
authors: Buchel
authors: F J
authors: FJ
authors: Bosch
authors: J
authors: J
authors: Janse van Rensburg
authors: E
authors: E
authors: Bezuidenhout
authors: C S
authors: CS
authors: de Vries
authors: J H
authors: JH
authors: van Zyl
authors: B D
authors: BD
authors: Middlecote
authors: H
authors: H
authors: de K Grundling
authors: J
authors: J
authors: Fevery
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001379:Azathioprine / Q000008:administration & dosage; D001416:Back Pain / Q000209:etiology; D044383:Black People; D002756:Cholagogues and Choleretics / Q000008:administration & dosage*; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics / Q000503:physiopathology; D003113:Colonoscopy / Q000379:methods; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics / Q000503:physiopathology; D003967:Diarrhea / Q000209:etiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D012720:Severity of Illness Index; D013019:South Africa / Q000453:epidemiology; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D002756:Cholagogues and Choleretics; D015796:HLA-B27 Antigen; D007166:Immunosuppressive Agents; D014580:Ursodeoxycholic Acid; D015122:Mercaptopurine; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D001379:Azathioprine; D008727:Methotrexate