title: Erosive and inflammatory joint changes in hereditary hemochromatosis arthropathy detected by low-field magnetic resonance imaging.
abstract: The aim of the article is to describe and characterize the hemochromatosis arthropathy of the hand by low-field MRI in symptomatic and asymptomatic patients. Forty-nine patients with hereditary hemochromatosis (37 with and twelve without arthropathy) were examined clinically and by low-field MRI of the hands. The examination showed heterogeneous degenerative and inflammatory joint changes such as erosions (in 84% of all symptomatic patients), synovitis (77%), bone marrow edema (38%), subchondral cysts (30%), tenosynovitis (30%), joint space narrowing (73%) and osteophytes (59%) including hook-shaped osteophytes at MCP joints (32%). Mild joint changes were also seen in a lower percentage of asymptomatic patients. This is the first larger study addressing the joint changes of the hand in hereditary hemochromatosis using low-field MRI. Our study emphasizes the inflammatory and destructive character of the arthropathy besides the well-known degenerative joint changes described in conventional X-ray. The impact of joint changes in asymptomatic patients deserves further investigation.
authors: Martin-Luther-University Hospital Halle (Saale), Halle, Saxony-Anhalt, Germany. katja.frenzen@medizin.uni-halle.de
authors: Katja
authors: K
authors: Frenzen
authors: Christoph
authors: C
authors: Schäfer
authors: Gernot
authors: G
authors: Keyßer
mesh_terms: D001845:Bone Cysts / Q000473:pathology*; D005260:Female; D050823:Hand Joints / Q000473:pathology*; D006432:Hemochromatosis / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013585:Synovitis / Q000473:pathology*; D013717:Tenosynovitis / Q000473:pathology*
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