title: Effects of acute sodium fluoride exposure on kidney function, water homeostasis, and renal handling of calcium and inorganic phosphate.
abstract: Fluoride compounds are abundant and widely distributed in the environment at a variety of concentrations. Further, fluoride induces toxic effects in target organs such as the liver and kidney. In this study, we performed an early analysis of renal function using a clearance technique in Wistar rats acutely exposed to fluoride at a plasma concentration of 0.625 μg/ml. Our results revealed that fluoride, at a concentration close to the concentration present in the serum after environmental exposure, induced a significant tubular dysfunction, resulting in diluted urine, impaired protein reabsorption, and increased calcium and phosphate urinary excretion. Our work demonstrates that even acute exposures to low concentrations of NaF may induce renal damage and confirms that, after exposure, the kidney participates directly in the calcium and phosphate deficiencies observed in fluoride-exposed populations.
authors: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional CINVESTAV-IPN, Av. IPN No. 2508 Col, San Pedro Zacatenco, Mexico City, CP 07360, Mexico.
authors: Mitzi Paola
authors: MP
authors: Santoyo-Sanchez
authors: Maria
authors: M
authors: del Carmen Silva-Lucero
authors: Laura
authors: L
authors: Arreola-Mendoza
authors: Olivier Christophe
authors: OC
authors: Barbier
mesh_terms: D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects; D001834:Body Water / Q000187:drug effects*; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008657:Metabolic Clearance Rate; D010710:Phosphates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D010710:Phosphates; D012969:Sodium Fluoride; D002118:Calcium