title: Woringer-Kolopp disease mimicking foot dermatitis.
abstract: Woringer-Kolopp disease, also known as localized pagetoid reticulosis, is a rare cutaneous lymphoproliferative disorder classified as a solitary variant of mycosis fungoides (MF). Despite the indolent and benign nature of the disease, misdiagnosis and inappropriate treatment may result in years of debilitating symptoms and even loss of function. We present the case of a patient with long-standing Woringer-Kolopp disease that mimicked foot dermatitis. Histopathologic examination demonstrated epidermotropic infiltration of atypical lymphocytes that were CD3+ CD4- CD8-. The patient was successfully treated with topical keratolytics and bexarotene gel 1% with minimal residual lesions after 8 years of follow-up. We discuss the characteristics of this rare disease in contrast with localized MF as well as more aggressive forms of epidermotropic T-cell lymphoma.
authors: Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors: Yongxue
authors: Y
authors: Yao
authors: Lawrence A
authors: LA
authors: Mark
mesh_terms: D000368:Aged; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D000077610:Bexarotene; D017252:CD3 Complex / Q000378:metabolism; D003879:Dermatologic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005533:Foot Dermatoses / Q000175:diagnosis*; D006801:Humans; D008297:Male; D056267:Pagetoid Reticulosis / Q000188:drug therapy / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D013601:T-Lymphocytes / Q000378:metabolism; D013764:Tetrahydronaphthalenes / Q000627:therapeutic use; D014508:Urea / Q000627:therapeutic use
chemical_list: D016588:Anticarcinogenic Agents; D017252:CD3 Complex; D003879:Dermatologic Agents; D013764:Tetrahydronaphthalenes; D014508:Urea; D000077610:Bexarotene