title: Aortic valve reconstruction with autologous pericardium for dialysis patients.
abstract: OBJECTIVE
  This study aimed to report on original aortic valve reconstruction for patients on dialysis.
  
  
  METHODS
  Aortic valve reconstruction has been performed on 404 cases from April 2007 through September 2011. Among them, 54 cases on haemodialysis were retrospectively studied. Forty-seven patients had aortic stenosis, 5 had aortic regurgitation (AR), and 2 had infective endocarditis. Mean age was 70.2 ± 8.5 years. There were 35 males and 19 females. There were 27 primary aortic valve reconstructions, 11 with CABG, 6 with ascending aortic replacement, 5 with mitral valve repair and 4 with maze. First, in the procedure, harvested pericardium was treated with 0.6% glutaraldehyde solution. After resecting the cusps, we measured the distance between commissures with original sizing instrument. Then, the pericardium was trimmed with the original template. Three cusps were sutured to each annulus.
  
  
  RESULTS
  Peak pressure gradient averaged to 66.0 ± 28.2 mmHg preoperatively, and decreased to 23.4 ± 10.7, 13.8 ± 5.5 and 13.3 ± 2.3 mmHg, 1 week, 1 year, and 3 years after the operation, respectively. No calcification was detected with echocardiographic follow-up. Recurrence of AR was not recorded with the mean follow-up of 847 days except for 1 case reoperated on for infective endocarditis 2.5 years after the operation. Three hospital deaths were recorded due to non-cardiac causes. Other patients were in good condition. There was no thromboembolic event.
  
  
  CONCLUSIONS
  Medium-term results are excellent. Since warfarin for dialysis patients becomes problematic, a postoperative warfarin-free status is desirable. Aortic valve reconstruction can provide patients with a better quality of life without warfarin.
authors: Department of Cardiovascular Surgery, Toho University Ohashi Medical Center, Meguro, Tokyo, Japan.
authors: Isamu
authors: I
authors: Kawase
authors: Shigeyuki
authors: S
authors: Ozaki
authors: Hiromasa
authors: H
authors: Yamashita
authors: Shin
authors: S
authors: Uchida
authors: Yukinari
authors: Y
authors: Nozawa
authors: Takayoshi
authors: T
authors: Matsuyama
authors: Mikio
authors: M
authors: Takatoh
authors: So
authors: S
authors: Hagiwara
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D058385:Cardiac Valve Annuloplasty / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D005260:Female; D005404:Fixatives; D005976:Glutaral; D006801:Humans; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000637:transplantation*; D012008:Recurrence; D006435:Renal Dialysis / Q000009:adverse effects / Q000401:mortality; D012086:Reoperation; D012189:Retrospective Studies; D013997:Time Factors; D016707:Tissue Fixation / Q000379:methods; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014859:Warfarin / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D005404:Fixatives; D014859:Warfarin; D005976:Glutaral
keywords: Aortic valve reconstruction; Autologous pericardium; Dialysis