title: Asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media.
abstract: Organocatalyzed asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media has been developed. The reactions proceeded efficiently in the presence of the MacMillan catalyst to give the desired products in good to excellent yields with moderate diastereoselectivities and excellent enantioselectivities.
authors: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
authors: Ying
authors: Y
authors: Zhang
authors: Shun-Yi
authors: SY
authors: Wang
authors: Xiao-Ping
authors: XP
authors: Xu
authors: Ran
authors: R
authors: Jiang
authors: Shun-Jun
authors: SJ
authors: Ji
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D048289:Imidazolidines / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000447:Aldehydes; D048289:Imidazolidines; D007211:Indoles; D014867:Water