title: Pre-transplant levels of ficolin-3 are associated with kidney graft survival.
abstract: Ficolin-3 is an initiator of the lectin complement pathway. The complement system is a mediator of the pathophysiology of graft rejection in kidney transplantation, but the role of ficolin-3 in this process is unknown. Using a prospective study design, 527 kidney transplanted patients were included. 97 blood donors served as controls. Ficolin-3, C4 and C3 were measured in pre-transplant as well as in control serum samples. In controls, deposition of ficolin-3, C4, C3 and the terminal complement complex (TCC) was measured in an assay based on acetylated albumin as matrix. The ficolin-3 levels correlated with the serum levels of C4 and C3. The serum levels of ficolin-3 correlated with the deposition of ficolin-3, C4, C3 and TCC. Survival analyses showed that high pre-transplant serum levels of ficolin-3 were associated with decreased graft survival. These results suggest an important role of ficolin-3 in the pathophysiology of kidney graft rejection.
authors: Laboratory of Molecular Medicine, Department of Clinical Immunology, Sect 7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors: Jakob T
authors: JT
authors: Bay
authors: Estrid
authors: E
authors: Hein
authors: Søren S
authors: SS
authors: Sørensen
authors: Jesper Melchior
authors: JM
authors: Hansen
authors: Peter
authors: P
authors: Garred
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003165:Complement System Proteins / Q000276:immunology; D005260:Female; D006023:Glycoproteins / Q000097:blood / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D037102:Lectins / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: C109662:FCN3 protein, human; D006023:Glycoproteins; D037102:Lectins; D003165:Complement System Proteins