title: Identification of cell surface antigen expression in canine hepatocellular carcinoma cell lines.
abstract: The characteristics of surface antigens in canine hepatocellular carcinoma (cHCC) have not been clarified. The objective of this study was to investigate surface antigens, which are considered as stem/progenitor or cancer cell markers, in cHCC cell lines. Expression of various antigens including CD29, CD34, CD44, CD90, CD133 and Dlk-1 was assessed in four cHCC cell lines by flow cytometry. CD44, CD133 and Dlk-1 expression was detectable in all cell lines, and three cell lines expressed CD29. These results indicate that CD29, CD44, CD133 and Dlk-1 have potential as suitable markers in cHCC identification, suggesting that these findings will contribute to the establishment of an early diagnostic tool for the identification of hepatocellular maturation processes.
authors: Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuoku, Sagamihara, Kanagawa 252-5201, Japan.
authors: Ayumi
authors: A
authors: Fujimoto
authors: Sakurako
authors: S
authors: Neo
authors: Chinatsu
authors: C
authors: Ishizuka
authors: Takashi
authors: T
authors: Kato
authors: Kazuhito
authors: K
authors: Segawa
authors: Shinpei
authors: S
authors: Kawarai
authors: Kikumi
authors: K
authors: Ogihara
authors: Masaharu
authors: M
authors: Hisasue
authors: Ryo
authors: R
authors: Tsuchiya
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D004283:Dog Diseases / Q000235:genetics / Q000378:metabolism*; D004285:Dogs; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D000954:Antigens, Surface