title: Incorporating endorectal MR elastography into multi-parametric MRI for prostate cancer imaging: Initial feasibility in volunteers.
abstract: OBJECTIVE
  To investigate the tolerability and technical feasibility of performing endorectal MR elastography (eMRE) in human volunteers within the representative age group commonly affected by prostate cancer.
  
  
  METHODS
  Endorectal MRE was conducted on seven volunteers in a 1.5 Tesla (T) MR imager using a rigid endorectal coil. Another five volunteers were imaged on a 3T MR imager using an inflatable balloon type endorectal coil. Tolerability was accessed for vibration amplitudes of ±1-50 μm and for frequencies of 100-300 Hz.
  
  
  RESULTS
  All 12 volunteers tolerated the displacements necessary to successfully perform eMRE. Shear waves with frequencies up to 300 Hz could propagate across the entire prostate using both coil designs.
  
  
  CONCLUSIONS
  The results of this study motivate further investigation of eMRE in prostate cancer patients to help determine if there is an added value of integrating eMRE into existing multi-parametric prostate MRI exams.
authors: Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
authors: Arvin
authors: A
authors: Arani
authors: Michael
authors: M
authors: Da Rosa
authors: Elizabeth
authors: E
authors: Ramsay
authors: Don B
authors: DB
authors: Plewes
authors: Masoom A
authors: MA
authors: Haider
authors: Rajiv
authors: R
authors: Chopra
mesh_terms: D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012007:Rectum; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: MR elastography; cancer; endorectal; prostate imaging; prostate stiffness; tissue stiffness