title: Detection of plasmid-mediated quinolone resistance determinants and the emergence of multidrug resistance in clinical isolates of Shigella in SiXian area, China.
abstract: A total of 123 Shigella isolates were collected from SiXian area in Anhui, China. Screening was carried out by polymerase chain reaction (PCR) amplification of plasmid-mediated quinolone resistance (PMQR) determinants. Different β-blactamases genes, plasmid-borne bla(AmpC), 16S rRNA methylase genes, integrons, and mutations in quinolone resistance-determining regions were analysed by PCR for the PMQR-positive isolates.
authors: Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors: Yu-lin
authors: YL
authors: Zhu
authors: Hai-fei
authors: HF
authors: Yang
authors: Yan-yan
authors: YY
authors: Liu
authors: Li-fen
authors: LF
authors: Hu
authors: Jun
authors: J
authors: Cheng
authors: Ying
authors: Y
authors: Ye
authors: Jia-bin
authors: JB
authors: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D002681:China / Q000453:epidemiology; D002939:Ciprofloxacin / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D004405:Dysentery, Bacillary / Q000453:epidemiology / Q000382:microbiology; D005798:Genes, Bacterial; D020459:Genes, rRNA; D006801:Humans; D032023:Integrons; D009154:Mutation; D010957:Plasmids / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012760:Shigella / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012336:RNA, Ribosomal, 16S; D002939:Ciprofloxacin; C048795:AmpC beta-lactamases; D001618:beta-Lactamases; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase