title: From one-photon to two-photon probes: "caged" compounds, actuators, and photoswitches.
abstract: Molecular systems that can be remotely controlled by light are gaining increasing importance in cell biology, physiology, and neurosciences because of the spatial and temporal precision that is achievable with laser microscopy. Two-photon excitation has significant advantages deep in biological tissues, but raises problems in the design of "smart" probes compatible with cell physiology. This Review discusses the chemical challenges in generating suitable two-photon probes.
authors: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS, Univ. Paris Descartes, 45 rue des Sts-Pères, 75270 Paris, France.
authors: Guillaume
authors: G
authors: Bort
authors: Thibault
authors: T
authors: Gallavardin
authors: David
authors: D
authors: Ogden
authors: Peter I
authors: PI
authors: Dalko
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D002468:Cell Physiological Phenomena; D002614:Chelating Agents / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000737:chemistry*; D009578:Nitrobenzenes / Q000737:chemistry; D055668:Photochemical Processes; D010777:Photochemistry; D017785:Photons; D015398:Signal Transduction
chemical_list: D002614:Chelating Agents; D047028:Macrocyclic Compounds; D009578:Nitrobenzenes