title: Adhesive microbeads for the targeting delivery of anticaries agents of vegetable origin.
abstract: The formulation of quinic acid, a food constituent demonstrating potential anticaries and antigingivitis properties, was investigated in an adhesive microparticulate delivery system with the goal of improving its effect by prolonging its residence time at the site of action. Alginate and chitosan were selected as mucoadhesive polymers. The microspheres were prepared by coacervation. Different types of alginates, polymers blends and crosslinking agent concentrations were considered and evaluated. The best results in terms of encapsulation efficiency, in vitro active agent release profile and in vitro adhesive properties, both to oral mucosa and to teeth surface, were obtained with a blend of Alginate Protanal LF200S: Alginate Protanal LF120LS 1:1.5 w/w, 0.1M CaCl(2), and chitosan coating, prepared by a one-step complex coacervation method. This microparticulate delivery system showed prolonged release of quinic acid, and could be used as an active component in chewing gums or mouthwashes for both caries and gingivitis prevention.
authors: Department of Drug Sciences, School of Pharmacy, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy. bice.conti@unipv.it
authors: Bice
authors: B
authors: Conti
authors: Barbara
authors: B
authors: Colzani
authors: Adele
authors: A
authors: Papetti
authors: Dora
authors: D
authors: Mascherpa
authors: Rossella
authors: R
authors: Dorati
authors: Ida
authors: I
authors: Genta
authors: Carla
authors: C
authors: Pruzzo
authors: Caterina
authors: C
authors: Signoretto
authors: Edjia
authors: E
authors: Zaura
authors: Peter
authors: P
authors: Lingström
authors: Itzak
authors: I
authors: Ofek
authors: Mike
authors: M
authors: Wilson
authors: David A
authors: DA
authors: Spratt
authors: Gabriella
authors: G
authors: Gazzani
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002327:Cariostatic Agents / Q000737:chemistry* / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008863:Microspheres; D010936:Plant Extracts; D011801:Quinic Acid / Q000737:chemistry* / Q000494:pharmacology; D014675:Vegetables / Q000737:chemistry*
chemical_list: D000464:Alginates; D002327:Cariostatic Agents; D004337:Drug Carriers; D010936:Plant Extracts; D011801:Quinic Acid; D048271:Chitosan