title: Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(II) complexes of heterosubstituted cyclens.
abstract: The Cu(II) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N).
authors: Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, D-14195 Berlin, Germany.
authors: Jan
authors: J
authors: Hormann
authors: Chrischani
authors: C
authors: Perera
authors: Naina
authors: N
authors: Deibel
authors: Dieter
authors: D
authors: Lentz
authors: Biprajit
authors: B
authors: Sarkar
authors: Nora
authors: N
authors: Kulak
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D000080027:Cyclams; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D053837:DNA Cleavage; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism
chemical_list: D056831:Coordination Complexes; D000080027:Cyclams; D006571:Heterocyclic Compounds; D003300:Copper; D004247:DNA; C038072:cyclen