title: [Renal cell carcinoma molecular biology. Prognostic and therapeutic usefulness].
abstract: Renal cell adenocarcinoma requires different therapeutic pathways because it is one of the most therapy-resistant tumors, on the other hand it is biologically one of the most attractive tumors. Its pathological classification has a genetic base. There is an anomaly of the Von Hippel Lindau gene in 80% of adenocarcinomas, being this fact determinant to know the biological characteristics of tumor initiation and development, as well as the identification of factors susceptible to be used as therapeutic targets. Since 2005 a group of molecules have been used in the treatment of metastatic adenocarcinomas and, even though therapeutic results are significant but not clinically relevant yet, we are sure they are a key way for more efficient future developments. The present study tries to make a tour on the research of the biological anomalies in renal adenocarcinoma with special emphasis in the Von HippelLindau gene.
authors: Departamento de Urología, Clínica Universitaria de Navarra, España. jzudaire@unav.es
authors: Juan Javier
authors: JJ
authors: Zudaire Bergera
authors: Aníbal
authors: A
authors: Rincón Mayans
authors: Jorge
authors: J
authors: Rioja Zuazu
authors: Javier
authors: J
authors: Barba Abad
authors: Luis
authors: L
authors: Romero Vargas
authors: Rubén
authors: R
authors: Algarra Navarro
authors: Antonio
authors: A
authors: Tienza Fernández
authors: José Enrique
authors: JE
authors: Robles García
authors: David
authors: D
authors: Rosell Costa
authors: José María
authors: JM
authors: Berián Polo
authors: Juan Ignacio
authors: JI
authors: Pascual Piédrola
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor