title: Nutrients related to GLP1 secretory responses.
abstract: The hormone glucagon-like peptide (GLP-1) is secreted from gut endocrine L cells in response to ingested nutrients. The activities of GLP-1 include stimulating insulin gene expression and biosynthesis, improving β-cell proliferation, exogenesis, and survival. Additionally, it prevents β-cell apoptosis induced by a variety of cytotoxic agents. In extrapancreatic tissues, GLP-1 suppresses hunger, delays gastric emptying, acts as an ileal brake, and increases glucose uptake. The pleiotropic actions of GLP-1, especially its glucose-lowering effect, gave rise to the suggestion that it is a novel approach to insulin resistance treatment. Hormones secreted from the gut including GLP-1, which are involved in the regulation of insulin sensitivity and secretions, have been found to be affected by nutrient intake. In recent years, there has been a growing interest in the effect nutrients may have on GLP-1 secretion; some frequently studied dietary constituents include monounsaturated fatty acids, fructooligosaccharides, and glutamine. This review focuses on the influence that the carbohydrate, fat, and protein components of a meal may have on the GLP-1 postprandial responses.
authors: Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Asieh
authors: A
authors: Mansour
authors: Saeed
authors: S
authors: Hosseini
authors: Bagher
authors: B
authors: Larijani
authors: Mohamad
authors: M
authors: Pajouhi
authors: Mohammad Reza
authors: MR
authors: Mohajeri-Tehrani
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D005746:Gastric Emptying; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism* / Q000502:physiology*; D005973:Glutamine / Q000008:administration & dosage; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D064306:Non-Nutritive Sweeteners / Q000008:administration & dosage; D019518:Postprandial Period
chemical_list: D004041:Dietary Fats; D004043:Dietary Fiber; D004044:Dietary Proteins; D007328:Insulin; D064306:Non-Nutritive Sweeteners; D005973:Glutamine; D052216:Glucagon-Like Peptide 1