title: Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer.
abstract: OBJECTIVE
  The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient.
  
  
  METHODS
  We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent assay and immunohistochemistry, respectively.
  
  
  RESULTS
  Shedding of soluble c-Met associates with total c-Met amount in pre-clinical models, and soluble c-Met correlates with both c-Met expression level and tumor size in human, high soluble c-Met predicts poorer outcome.
authors: Department of Radiology, Huashan Hospital of Fudan University, Shanghai, China.
authors: Le
authors: L
authors: Fu
authors: Wei
authors: W
authors: Guo
authors: Bingshan
authors: B
authors: Liu
authors: Linlin
authors: L
authors: Sun
authors: Zhenghong
authors: Z
authors: Bi
authors: Li
authors: L
authors: Zhu
authors: Xinyan
authors: X
authors: Wang
authors: Bin
authors: B
authors: Liu
authors: Qian
authors: Q
authors: Xie
authors: Ke
authors: K
authors: Li
mesh_terms: D000368:Aged; D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000235:genetics / Q000378:metabolism / Q000401:mortality; D045744:Cell Line, Tumor; D005260:Female; D015870:Gene Expression; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000235:genetics / Q000378:metabolism / Q000401:mortality; D008297:Male; D051379:Mice; D008875:Middle Aged; D009367:Neoplasm Staging; D009368:Neoplasm Transplantation; D010446:Peptide Fragments / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis; D017434:Protein Structure, Tertiary; D019859:Proto-Oncogene Proteins c-met / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D012995:Solubility; D016019:Survival Analysis; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D010446:Peptide Fragments; D019859:Proto-Oncogene Proteins c-met