title: Nanowire-based electrode for acute in vivo neural recordings in the brain.
abstract: We present an electrode, based on structurally controlled nanowires, as a first step towards developing a useful nanostructured device for neurophysiological measurements in vivo. The sensing part of the electrode is made of a metal film deposited on top of an array of epitaxially grown gallium phosphide nanowires. We achieved the first functional testing of the nanowire-based electrode by performing acute in vivo recordings in the rat cerebral cortex and withstanding multiple brain implantations. Due to the controllable geometry of the nanowires, this type of electrode can be used as a model system for further analysis of the functional properties of nanostructured neuronal interfaces in vivo.
authors: Division of Solid State Physics and The Nanometer Structure Consortium, Lund University, Lund, Sweden.
authors: Dmitry B
authors: DB
authors: Suyatin
authors: Lars
authors: L
authors: Wallman
authors: Jonas
authors: J
authors: Thelin
authors: Christelle N
authors: CN
authors: Prinz
authors: Henrik
authors: H
authors: Jörntell
authors: Lars
authors: L
authors: Samuelson
authors: Lars
authors: L
authors: Montelius
authors: Jens
authors: J
authors: Schouenborg
mesh_terms: D000200:Action Potentials; D000818:Animals; D001921:Brain / Q000502:physiology; D046690:Deep Brain Stimulation; D017097:Electric Impedance; D004566:Electrodes; D005260:Female; D005708:Gallium / Q000737:chemistry; D020007:Implants, Experimental; D053770:Nanowires / Q000648:ultrastructure; D010720:Phosphines / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000502:physiology*
chemical_list: D010720:Phosphines; C485338:gallium phosphide; D005708:Gallium