title: Pretreatment body mass index as an independent prognostic factor in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy: findings from a randomised trial.
abstract: OBJECTIVE
  To investigate the relationship between the pretreatment body mass index (BMI) and the clinical outcomes in patients with locoregionally advanced nasopharyngeal carcinoma treated with combination of chemotherapy and radiotherapy.
  
  
  METHODS
  From August 2002 to April 2005, 400 patients with stage III or stage IVa nasopharyngeal carcinoma were recruited for a randomised clinical trial of induction chemotherapy combined with radiotherapy or concurrent chemoradiotherapy. The patients were divided into four groups of underweight (BMI<18.5kg/m(2)), normal weight (BMI 18.5-22.9kg/m(2)), overweight (BMI 23.0-27.4kg/m(2)) or obese (BMI≥27.5kg/m(2)) according to the World Health Organization classifications for Asian populations. The differences in the long-term survival, of these four BMI groups were analysed.
  
  
  RESULTS
  The 5-year failure-free survival rates for the underweight, normal weight, overweight and obese groups were 44%, 61%, 68% and 73%, respectively (p=0.014), and the 5-year overall survival rates were 51%, 68%, 80% and 72% (p=0.001), respectively. BMI was a strongly favoured prognostic factor of overall survival and failure-free survival in a Cox regression model.
  
  
  CONCLUSIONS
  Pretreatment body mass index was a simple, reliable independent prognostic factor for patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy.
authors: State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, PR China; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, PR China.
authors: Pei-Yu
authors: PY
authors: Huang
authors: Cheng-Tao
authors: CT
authors: Wang
authors: Ka-Jia
authors: KJ
authors: Cao
authors: Xiang
authors: X
authors: Guo
authors: Ling
authors: L
authors: Guo
authors: Hao-Yuan
authors: HY
authors: Mo
authors: Bi-Xiu
authors: BX
authors: Wen
authors: Yi-Shan
authors: YS
authors: Wu
authors: Hai-Qiang
authors: HQ
authors: Mai
authors: Ming-Huang
authors: MH
authors: Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D059248:Chemoradiotherapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007970:Leukopenia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D052016:Mucositis / Q000209:etiology; D015999:Multivariate Analysis; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D009305:Nasopharynx / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D050177:Overweight; D011379:Prognosis; D016016:Proportional Hazards Models; D016032:Randomized Controlled Trials as Topic; D055815:Young Adult