title: Direct detection pays off for electron cryo-microscopy.
abstract: Improved electron detectors and image-processing techniques will allow the structures of macromolecules to be determined from tens of thousands of single-particle cryo-EM images, rather than the hundreds of thousands needed previously.
authors: is at the  Department of Biochemistry and the Howard Hughes Medical Institute, Brandeis University ,  Waltham ,  Untied States niko@brandeis.edu.
authors: Nikolaus
authors: N
authors: Grigorieff
mesh_terms: D020285:Cryoelectron Microscopy / Q000379:methods*; D007091:Image Processing, Computer-Assisted
keywords: Bayesian; Direct electron detectors; Electron microscopy; Image processing; S. cerevisiae; T. thermophilus; ribosome