title: Streamlined catalytic asymmetric synthesis of atorvastatin.
abstract: An efficient enantioselective synthetic route to atorvastatin was developed based on a direct catalytic asymmetric aldol reaction. The expensive chiral ligand used in the initial aldol reaction was readily recovered (91 %) and reused. Implementation of an oxy-Michael reaction for the construction of the syn-1,3-diol unit eliminated several redundant steps, allowing for rapid access to the common intermediate in six steps.
authors: Institute of Microbial Chemistry, Tokyo (BIKAKEN), 3-14-23 Kamiosaki, Tokyo 141-0021, Japan.
authors: Yuji
authors: Y
authors: Kawato
authors: Sandeep
authors: S
authors: Chaudhary
authors: Naoya
authors: N
authors: Kumagai
authors: Masakatsu
authors: M
authors: Shibasaki
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000069059:Atorvastatin; D002384:Catalysis; D006538:Heptanoic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D011758:Pyrroles; C116609:3-hydroxybutanal; D000069059:Atorvastatin