title: [Post-infectious bronchiolitis obliterans].
abstract: Post-infectious bronchiolitis obliterans (BO) is characterized by inflammatory and fibrotic lesions of small airways following a pulmonary infection and leading to some degree of airway obstruction. It represents a rare cause of chronic obstructive pulmonary disease, and is probably underestimated, especially when the lesions affect small areas of the lungs. The clinical features differ between children and adults. In children, adenovirus is the most frequently involved infectious agent, especially the more virulent serotypes 3, 7 and 21. The clinical and radiological signs vary widely and the functional outcome depends on the extent of the lung injury. The diagnosis is based on the medical history, the CT-scan and functional data. The treatment is symptomatic. The most severe forms may result in chronic respiratory insufficiency. In adults, the frequency of obstructive injuries of the small airways in the context of lung infection is unclear. Parenchymal lesions are often present, resulting in BO with organizing pneumonia. These lesions alter the clinical presentation and the radiographic features of the initial infectious disease and often prove difficult to diagnose and manage. Several authors have published clinical cases describing presumed efficacy of systemic corticosteroids but the data are scarce.
authors: Service de pneumologie et allergologie pédiatriques, université Paris Descartes, hôpital Necker-Enfants-Malades, Assistance publique des Hôpitaux de Paris, 75015 Paris, France. j.deblic@nck.aphp.fr
authors: J
authors: J
authors: de Blic
authors: A
authors: A
authors: Deschildre
authors: T
authors: T
authors: Chinet
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D001989:Bronchiolitis Obliterans / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D018549:Cryptogenic Organizing Pneumonia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D008168:Lung / Q000473:pathology; D016040:Lung Transplantation; D010102:Oxygen Inhalation Therapy; D011013:Pneumonectomy / Q000379:methods; D011379:Prognosis; D001261:Pulmonary Atelectasis / Q000209:etiology / Q000601:surgery; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology; D012141:Respiratory Tract Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology / Q000821:virology; D012307:Risk Factors; D014611:Vaccination
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D001993:Bronchodilator Agents