title: The effect of pain after total knee arthroplasty on the contralateral, nonreplaced knee.
abstract: BACKGROUND
  Osteoarthritis is associated with a strong biomechanical component. Persistent pain in the index knee after total knee arthroplasty could lead to pain in the contralateral knee. The purpose of the present study was to examine whether a change in the natural history of pain in the contralateral knee was related to postoperative pain in the index knee.
  
  
  METHODS
  Seven hundred and seventy-two patients undergoing primary unilateral total knee arthroplasty with use of the Kinemax prosthesis for the treatment of osteoarthritis comprised the cohort (Kinemax Outcomes Study cohort). Patients were assessed preoperatively and were followed for twenty-four months after surgery with use of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). We collected separate WOMAC pain scores for the index knee and the contralateral knee. Our primary outcome measure was the WOMAC pain score (rescaled to 100, with 100 being the best score) for the contralateral knee at three, twelve, and twenty-four months. We examined whether within-subject changes in the WOMAC pain score for the contralateral knee were predicted by the WOMAC pain score for the index knee at three months with use of linear regression and multilevel models after adjustment for sex, age, country, body mass index, income, and mental well-being.
  
  
  RESULTS
  Improvement in terms of pain was observed in both the index and contralateral knees between baseline and three months. Subsequently, there was a modest deterioration of 3.5 units per year (standard deviation, 9.8 units per year) in the contralateral knee (p < 0.001), which was not predicted by pain in the index knee shortly after surgery (p > 0.6).
  
  
  CONCLUSIONS
  Pain in the index knee at three months after total knee arthroplasty did not appear to predict a symptomatic increase in pain in the contralateral knee over two years of follow-up in our cohort. The contralateral knee did not require any additional clinical surveillance over and above the patients' reports on their symptoms.
authors: School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol BS8 2PS, United Kingdom. hsmith22@doctors.org.uk
authors: H K
authors: HK
authors: Smith
authors: V
authors: V
authors: Wylde
authors: E A
authors: EA
authors: Lingard
authors: A
authors: A
authors: Blom
authors: C
authors: C
authors: Metcalfe
authors: Y
authors: Y
authors: Ben-Shlomo
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D015897:Comorbidity; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007720:Knee Prosthesis; D016014:Linear Models; D008297:Male; D020370:Osteoarthritis, Knee / Q000503:physiopathology* / Q000601:surgery*; D010147:Pain Measurement; D011446:Prospective Studies; D011788:Quality of Life; D016059:Range of Motion, Articular; D020127:Recovery of Function; D011795:Surveys and Questionnaires; D016896:Treatment Outcome