title: Th22, but not Th17 might be a good index to predict the tissue involvement of systemic lupus erythematosus.
abstract: OBJECTIVE
  T-helper (Th) cells abnormalities are considered to be associated with the pathogenesis of Systemic lupus erythematosus (SLE). Recently, The Th22 cells have been identified and implicated in the pathogenesis of autoimmune diseases such as Rheumatoid arthritis (RA), although therir role in Systemic lupus erythematosus (SLE) remains unclear. The present study intends to investigate their roles in SLE.
  
  
  METHODS
  Clinical data were collected in 65 SLE patients and 30 healthy controls. The patients were divided into active and inactive groups. CD4(+)IFN-γ(-)IL-17(-)IL-22(+)Tcells (Th22 cells),CD4(+) IFN-γ(-)IL-22(-)IL-17(+)T cells (Th17 cells),and CD4(+) IFN-γ(+) (Th1 cells) were assayed by flow cytometry. Serum interleukin-22 (IL-22) and IL-17 levels were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The main observation focused on increased Th22 cells in patients with sole lupus skin disease and decreased Th22 cells in patients with sole lupus nephritis. Likewise, concentrations of serum IL-22 were increased in patients with sole lupus skin disease, and decreased in patients with sole lupus nephritis. Additionally, there was a positive correlation between the percentage of Th22 cells and IL-22 production. The percentage of Th17 cells or concentration of serum IL-17 correlated positively with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).
  
  
  CONCLUSIONS
  Th22 seems to be a more significant index to predict the tissue involvement of SLE than Th17, although Th17 may play a role in the activity of SLE.
authors: Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310009, People's Republic of China.
authors: Xu-yan
authors: XY
authors: Yang
authors: Hui-ying
authors: HY
authors: Wang
authors: Xiao-ying
authors: XY
authors: Zhao
authors: Li-juan
authors: LJ
authors: Wang
authors: Qing-hua
authors: QH
authors: Lv
authors: Qing-qing
authors: QQ
authors: Wang
mesh_terms: D000328:Adult; D015704:CD4 Antigens / Q000378:metabolism; D002469:Cell Separation; D003872:Dermatitis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D020381:Interleukin-17 / Q000097:blood / Q000276:immunology; D007378:Interleukins / Q000097:blood / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology*; D008181:Lupus Nephritis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D011379:Prognosis; D012720:Severity of Illness Index; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D055815:Young Adult; D000097043:Interleukin-22
chemical_list: D015704:CD4 Antigens; D007371:Interferon-gamma; D020381:Interleukin-17; D007378:Interleukins; D000097043:Interleukin-22