title: Iron oxide magnetic nanoparticles with versatile surface functions based on dopamine anchors.
abstract: The synthesis of multifunctional magnetic nanoparticles (MF-MPs) is one of the most active research areas in advanced materials as their multifunctional surfaces allow conjugation of biological and chemical molecules, thus making it possible to achieve target-specific diagnostic in parallel to therapeutics. We report here a simple strategy to integrate in a one-step reaction several reactive sites onto the particles. The preparation of MF-MPs is based on their simultaneous modification with differently functionalized dopamine derivatives using simple solution chemistry. The formed MF-MPs show comparable magnetic properties to those of naked nanoparticles with almost unaltered particle size of around 25 nm. The different termini, amine, azide and maleimide functions, enable further functionalization of MF-MPs by the grafting-on approach. Michael addition, Cu(i) catalyzed « click » chemistry and amidation reactions are performed on the MF-MPs integrating subsequently 6-(ferrocenyl)-hexanethiol, horseradish peroxidase (HRP) and mannose.
authors: Institut de Recherche Interdisciplinaire (IRI, USR 3078 CNRS), Université Lille 1, Parc de Haute Borne, 50 Avenue de Halley, BP 70478, 59658 Villeneuve d'Ascq, France.
authors: Mykola
authors: M
authors: Mazur
authors: Alexandre
authors: A
authors: Barras
authors: Victor
authors: V
authors: Kuncser
authors: Andrei
authors: A
authors: Galatanu
authors: Vladimir
authors: V
authors: Zaitzev
authors: Kostiantyn V
authors: KV
authors: Turcheniuk
authors: Patrice
authors: P
authors: Woisel
authors: Joel
authors: J
authors: Lyskawa
authors: William
authors: W
authors: Laure
authors: Aloysius
authors: A
authors: Siriwardena
authors: Rabah
authors: R
authors: Boukherroub
authors: Sabine
authors: S
authors: Szunerits
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001386:Azides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D004298:Dopamine / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D006860:Hydrogen Bonding; D008280:Magnetics / Q000295:instrumentation / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008301:Maleimides / Q000737:chemistry / Q000494:pharmacology; D010316:Particle Size; D013499:Surface Properties
chemical_list: D000480:Alkynes; D001386:Azides; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D008301:Maleimides; C000499:ferric oxide; C043592:maleimide; D004298:Dopamine