title: Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007).
abstract: The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma (OSA) and to examine factors for their impact on metastasis-free interval (MFI) and survival time (ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic index (MI) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty-nine dogs (58%) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST. Grade also influenced MFI and ST, with 5/21 (24%) dogs with grade II/III tumours metastasis-free at one year versus 16/22 (72%) dogs with grade I tumours (P = 0.002); and 5/21 (24%) dogs with grade II/III tumours alive versus 17/22 (77%) dogs with grade I tumours (P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST.
authors: College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
authors: V J
authors: VJ
authors: Coyle
authors: College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
authors: K M
authors: KM
authors: Rassnick
authors: College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
authors: L B
authors: LB
authors: Borst
authors: Davis School of Veterinary Medicine, University of California, Davis, CA, USA.
authors: C O
authors: CO
authors: Rodriguez
authors: College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors: N C
authors: NC
authors: Northrup
authors: College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
authors: T M
authors: TM
authors: Fan
authors: College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
authors: L D
authors: LD
authors: Garrett
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D008940:Mitotic Index; D060787:Neoplasm Grading; D012516:Osteosarcoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents
keywords: chemotherapy; grade; jaw; mitotic index; oral tumour