title: Probing heterogeneity of cortical bone with ultrasound axial transmission.
abstract: In clinical examination of long cortical bones based on ultrasound axial transmission, the parameter currently used as indicator of bone fragility is the velocity of the first arriving signal (VFAS). VFAS is inherently related to the material properties of the bone site. However, experimental uncertainties may hide the true sensitivity of VFAS to elastic characteristics of bone. Measurements are performed with a multi-element compact array placed in contact with the bone. Therefore, VFAS measurements may be biased by variability imposed by geometrical irregularities of the sample below the probe and/or by probe misalignment. In this paper, we test the assumption that despite experimental errors, VFAS variations resulting from material properties can be measured. The methodology was to compare VFAS and velocities of compression bulk waves (VBWs) on carefully matched sites around the circumference of a test sample (bovine femur). VBW was mapped on bone cross-sections using a through-transmission technique. VBW and VFAS were highly correlated [R² = 0.80, root mean square error = 23 m·s⁻¹, p < 10⁻⁵] and the slope of the linear regression was close to 1 except in a part of the circumference with a pronounced curvature. In measurements performed with the same protocol as for clinical measurements, regions with different material properties (reflected by VBW) could be identified. This work demonstrates that within-specimen variations of material properties can be assessed with a technique available for in vivo measurements.
authors: Laboratoire d’Imagerie Parametrique, UMR 7623, Universite Pierre et Marie Curie-Paris VI, Paris, France. jfoiret@gmail.com
authors: Josquin
authors: J
authors: Foiret
authors: Quentin
authors: Q
authors: Grimal
authors: Maryline
authors: M
authors: Talmant
authors: Roberto
authors: R
authors: Longo
authors: Pascal
authors: P
authors: Laugier
mesh_terms: D000465:Algorithms; D000818:Animals; D002417:Cattle; D005269:Femur / Q000737:chemistry* / Q000000981:diagnostic imaging*; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D012815:Signal Processing, Computer-Assisted; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*