title: Novel cyclopentenone derivatives produced by a rare actinobacterial strain Actinoalloteichus nanshanensis sp. nov. NEAU 119.
abstract: Four novel cyclopentenone derivatives (1-4), characterising a cyclopentenone ring conjugated with a 1,8-dioxadecalin, were isolated from rare actinobacterial strain Actinoalloteichus nanshanensis sp. nov. NEAU 119. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. Bioassays indicated that compounds 1-4 showed low cytotoxicities against human leukaemia cell line K562 and human renal carcinoma cell line ACHN. To the best of our knowledge, this is the first example of isolation of C11 cyclopentenones from actinomycetes.
authors: a School of Life Science, Life Science and Biotechnology Research Center, Northeast Agricultural University , Harbin , 150030 , People's Republic of China.
authors: Xiang-Jing
authors: XJ
authors: Wang
authors: Ji
authors: J
authors: Zhang
authors: Ji-Dong
authors: JD
authors: Wang
authors: Ping-Ting
authors: PT
authors: Qian
authors: Chong-Xi
authors: CX
authors: Liu
authors: Wen-Sheng
authors: WS
authors: Xiang
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D003517:Cyclopentanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D012232:Rhizoctonia / Q000187:drug effects; D013045:Species Specificity; D013057:Spectrum Analysis; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D003517:Cyclopentanes; C013905:cyclopentenone