title: Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer.
abstract: OBJECTIVE
  We aimed to improve diagnostic accuracy of (18)F-fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation.
  
  
  METHODS
  44 gastric cancer patients (M:F=30:14, age ± std=62.1 ± 14.5 y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT.
  
  
  RESULTS
  48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50%=24/48) was significantly improved by regional PET/CT (75%=36/48, p<0.005). Sensitivity of whole body PET/CT (24.6%=15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1%=22/61, p<0.01), whereas specificity of whole body PET/CT (99.3%=285/287) was not compromised by regional PET/CT (98.3%=282/287, p>0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p=0.0003).
  
  
  CONCLUSIONS
  Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.
authors: Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Republic of Korea. suji76@hanmail.net
authors: Soo Jin
authors: SJ
authors: Lee
authors: Won Woo
authors: WW
authors: Lee
authors: Hai-Jeon
authors: HJ
authors: Yoon
authors: Ho-Young
authors: HY
authors: Lee
authors: Kyoung Ho
authors: KH
authors: Lee
authors: Young Hoon
authors: YH
authors: Kim
authors: Do Joong
authors: DJ
authors: Park
authors: Hyung-Ho
authors: HH
authors: Kim
authors: Young
authors: Y
authors: So
authors: Sang Eun
authors: SE
authors: Kim
mesh_terms: D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000706:statistics & numerical data; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000401:mortality*; D049268:Positron-Emission Tomography / Q000706:statistics & numerical data*; D015995:Prevalence; D011379:Prognosis; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D056910:Republic of Korea / Q000453:epidemiology; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000401:mortality*; D016019:Survival Analysis; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*; D014867:Water
chemical_list: D019275:Radiopharmaceuticals; D014867:Water; D019788:Fluorodeoxyglucose F18