title: Protective Effects of Capparis zeylanica Linn. Leaf Extract on Gastric Lesions in Experimental Animals.
abstract: The aim of the study was to study the anti-ulcer activity of the methanolic extract of the leaves of Capparis zeylanica Linn on experimental animal models. The methanol extract of Capparis zeylanica Linn. leaves was investigated for anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats. HCl-Ethanol induced ulcer in mice and indomethacin induced ulcer in rats at 200 mg/kg body weight p.o. A significant (p<0.01, p<0.001) anti-ulcer activity was observed in all the models. Pylorus ligation showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 88.5% ulcer inhibition in HCl-ethanol induced ulcer and 83.78% inhibition in indomethacin induced ulcer.
authors: Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Palakkad, India.
authors: Karanayil R
authors: KR
authors: Sini
authors: Barij N
authors: BN
authors: Sinha
authors: Aiyolu
authors: A
authors: Rajasekaran
keywords: Aspirin; Gastric ulcer; Indomethacin; Mice; Plant extract; Rats