title: Gene therapy for vein graft failure.
abstract: The main pathologenesis of vein graft restenosis is neointimal hyperplasia associated with vascular smooth muscle cell migration and proliferation. Gene therapy offers a novel treatment method for reducing or delaying early thrombosis, intimal hyperplasia, and late atherosclerosis. In this review, we will (1) describe sequential pathologies of vein graft disease; (2) summarize the applications of gene therapy in vein graft restenosis; and (3) discuss novel gene therapy for vein graft failure.
authors: Department of Cardiothoracic Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing, PR China.
authors: Xiao-Wen
authors: XW
authors: Wang
authors: Xing-Ji
authors: XJ
authors: Zhao
authors: Xiao-Yong
authors: XY
authors: Xiang
mesh_terms: D001026:Coronary Artery Bypass / Q000379:methods*; D023903:Coronary Restenosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D058426:Neointima / Q000150:complications / Q000517:prevention & control; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000517:prevention & control; D012501:Saphenous Vein / Q000473:pathology / Q000637:transplantation*; D013927:Thrombosis / Q000150:complications / Q000517:prevention & control