title: Palladium(II) complexes as biologically potent metallo-drugs: synthesis, spectral characterization, DNA interaction studies and antibacterial activity.
abstract: Four novel mononuclear Pd(II) complexes have been synthesized with the biologically active Schiff base ligands (L1-L4) derived from 3-amino-2-methyl-4(3H)-quinazolinone. The structure of the complexes has been proposed by elemental analysis, molar conductance, IR, (1)H NMR, mass, UV-Vis spectrometric and thermal studies. The investigation of interaction of the complexes with calf thymus DNA (CT-DNA) has been performed with absorption and fluorescence spectroscopic studies. The nuclease activity was done using pUC19 supercoiled DNA by gel-electrophoresis. All the ligands and their Pd(II) complexes have also been screened for their antibacterial activity by discolor diffusion technique.
authors: Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560 012, Karnataka, India. shivachemist@gmail.com
authors: Kollur Shiva
authors: KS
authors: Prasad
authors: Linganna Shiva
authors: LS
authors: Kumar
authors: Shivamallu
authors: S
authors: Chandan
authors: R M
authors: RM
authors: Naveen Kumar
authors: Hosakere D
authors: HD
authors: Revanasiddappa
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002417:Cattle; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004270:DNA, Circular / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010165:Palladium / Q000737:chemistry* / Q000494:pharmacology*; D010957:Plasmids / Q000187:drug effects; D052999:Quinazolinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D004270:DNA, Circular; D052999:Quinazolinones; D012545:Schiff Bases; C067712:2-methyl-4(3H)-quinazolinone; D010165:Palladium; D004247:DNA; C427203:calf thymus DNA