title: Association of age and CKD with prognosis of myocardial infarction.
abstract: OBJECTIVE
  CKD is a well known poor prognostic factor in myocardial infarction (MI). This study evaluated the prognostic significance of CKD, particularly in association with increasing age, in MI patients.
  
  
  METHODS
  This study was based on a retrospective cohort, the Korean Acute Myocardial Infarction Registry. Patients with a discharge diagnosis of MI were analyzed to investigate the association of CKD with mortality risk according to age. A total of 11,268 patients (mean age 63.0±12.6 years) were included and followed for 1 year.
  
  
  RESULTS
  In the full cohort, 26% of patients had CKD (n=2929). The prevalence of CKD was higher with advancing age. Eight hundred sixty-one patients (7.6%) died and the interaction for 1-year mortality between age strata and estimated GFR (eGFR) strata was significant (P<0.001). Within each age category, the absolute 1-year mortality was higher in patients with a low eGFR. However, the adjusted relative mortality risk for a low eGFR was lower with increasing age (adjusted hazard ratio [95% confidence interval] for 1-year mortality at eGFR <30 ml/min per 1.73 m(2): 4.84 [1.93-12.15], 4.53 [2.42-8.47], 3.51 [2.42-5.09], and 3.30 [2.41-4.52] for patients aged <55, 55-64, 65-74, and ≥75 years compared with those with eGFR ≥60 ml/min per 1.73 m(2), respectively).
  
  
  CONCLUSIONS
  For all age categories, the overall mortality was significantly higher as eGFR declined. The association of a lower eGFR with mortality was weaker with increasing age, indicating that the prognostic significance of CKD in MI patients is age dependent.
authors: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors: Joon Seok
authors: JS
authors: Choi
authors: Min Jee
authors: MJ
authors: Kim
authors: Yong Un
authors: YU
authors: Kang
authors: Chang Seong
authors: CS
authors: Kim
authors: Eun Hui
authors: EH
authors: Bae
authors: Seong Kwon
authors: SK
authors: Ma
authors: Young-Keun
authors: YK
authors: Ahn
authors: Myung Ho
authors: MH
authors: Jeong
authors: Young Jo
authors: YJ
authors: Kim
authors: Myeong Chan
authors: MC
authors: Cho
authors: Chong Jin
authors: CJ
authors: Kim
authors: Soo Wan
authors: SW
authors: Kim
mesh_terms: D000367:Age Factors; D000368:Aged; D016009:Chi-Square Distribution; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000196:embryology* / Q000401:mortality; D010351:Patient Discharge; D015995:Prevalence; D011379:Prognosis; D016016:Proportional Hazards Models; D012042:Registries; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors