title: [Peculiarities of the circulating phagocytes functional activity in patients with different forms of drug-resistant pulmonary tuberculosis].
abstract: Functional activity of circulating phagocytes (macrophages--Ms and neutrophils--Ns) was studied in 30 patients with infiltrative (I) and 30 patients with fibro-cavernous (FC) pulmonary tuberculosis (PT). Difference of the functional activity of both types of cells depending on the PT form was revealed: more significant increase in the oxygen-depending activity in FCPT while bactericide potential estimated with a zymosane induced NST-test was more pronounced in IPT patients. These data correlate with the blood levels of neopterin and elastase, the markers of the M and N activity, respectively. Participation of intracellular ADA in realization of oxygen-depending processes was demonstrated. Results of the multivariant analysis of the whole complex of the studied phagocyte characteristics, reflect their different roles in ther pathological process a prevailing role of Ms in the firstly diagnosed acute tuberculosis process (IPT) and Ns in the chronic progressive process (FCT).
authors: O T
authors: OT
authors: Titarenko
authors: M E
authors: ME
authors: D'iakova
authors: D S
authors: DS
authors: Ésmedliaeva
authors: M V
authors: MV
authors: Pavlova
authors: A V
authors: AV
authors: El'kin
authors: N P
authors: NP
authors: Alekseeva
authors: B B
authors: BB
authors: Bondarenko
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006801:Humans; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology; D008297:Male; D019798:Neopterin / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism* / Q000473:pathology; D010196:Pancreatic Elastase / Q000378:metabolism; D018088:Tuberculosis, Multidrug-Resistant / Q000378:metabolism* / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000378:metabolism* / Q000473:pathology; D015054:Zymosan / Q000494:pharmacology
chemical_list: D015415:Biomarkers; D019798:Neopterin; D015054:Zymosan; D010196:Pancreatic Elastase