title: Malignant biliary obstruction significantly increases serum lipid levels: a novel biochemical tumor marker?
abstract: OBJECTIVE
  We aimed to investigate the alterations in serum lipid levels due to biliary obstruction associated with benign and malignant cases. Also, we aimed to examine the possibility of the theory that extremely high serum lipid levels can predict the malignant biliary obstruction in the differantial diagnosis.
  
  
  METHODS
  Three hundred twenty two patients who were performed endoscopic retrograde cholangiopancreatography with the intrahepatic and extrahepatic cholestasis were reviewed in the period from September 2007 to October 2010.
  
  
  RESULTS
  In the malignant obstruction group, meaningfully higher total cholesterol (p<0,001), low-density lipoprotein (p>0.05) and triglycerides (p<0.05) were observed but high-density lipoprotein (p<0.05) levels were lower. The receiver operating characteristic analysis showed that total cholesterol (246.74 mg/dL or less, sensitivity: 84.3%, specificity: 83.3%, area under the curve: 0.705 (0.620-0.790) (p<0.001)) and high-density lipoprotein cholesterol (area under the curve: 0.577 (0.444-0.710)) were predictors of malignant biliary obstruction.
  
  
  CONCLUSIONS
  Serum lipid profile may be used as an applicant marker to identify malignant reasons of the obstructive jaundice.
authors: Gastroenterology Department, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
authors: Yusuf
authors: Y
authors: Yazgan
authors: Kemal
authors: K
authors: Oncu
authors: Mustafa
authors: M
authors: Kaplan
authors: Alpaslan
authors: A
authors: Tanoglu
authors: Irfan
authors: I
authors: Kucuk
authors: Mustafa
authors: M
authors: Dιnc
authors: Levent
authors: L
authors: Demιrturk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002779:Cholestasis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D002784:Cholesterol / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014280:Triglycerides / Q000097:blood; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol