title: Influence of bariatric surgery on the use and pharmacokinetics of some major drug classes.
abstract: The purpose of this review is to evaluate the influence of bariatric surgery on the use and pharmacokinetics of some frequently used drugs. A PubMed literature search was conducted. Literature was included on influence of bariatric surgery on pharmacoepidemiology and pharmacokinetics. Drug classes to be searched for were antidepressants, antidiabetics, statins, antihypertensive agents, corticosteroids, oral contraceptives, and thyroid drugs. A reduction in the use of medication by patients after bariatric surgery has been reported for various drug classes. Very few studies have been published on the influence of bariatric surgery on the pharmacokinetics of drugs. After bariatric surgery, theoretically, reduced drug absorption may occur. Correct dosing and choosing the right dosage form for drugs used by patients after bariatric surgery are necessary for optimal pharmacotherapy. Therefore, more clinical studies are needed on the influence of bariatric surgery on the pharmacokinetics of major drugs.
authors: Department of Clinical Pharmacy and Clinical Pharmacology, Medisch Centrum Leeuwarden, Leeuwarden, The Netherlands. j.p.yska@znb.nl
authors: Jan Peter
authors: JP
authors: Yska
authors: Susanne
authors: S
authors: van der Linde
authors: Véronique V
authors: VV
authors: Tapper
authors: Jan A
authors: JA
authors: Apers
authors: Marloes
authors: M
authors: Emous
authors: Erik R
authors: ER
authors: Totté
authors: Bob
authors: B
authors: Wilffert
authors: Eric N
authors: EN
authors: van Roon
mesh_terms: D000928:Antidepressive Agents / Q000493:pharmacokinetics*; D000959:Antihypertensive Agents / Q000493:pharmacokinetics*; D013956:Antithyroid Agents / Q000493:pharmacokinetics*; D050110:Bariatric Surgery / Q000009:adverse effects*; D003276:Contraceptives, Oral / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000493:pharmacokinetics*; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics*; D008297:Male; D009767:Obesity, Morbid / Q000378:metabolism / Q000601:surgery*; D017410:Practice Guidelines as Topic
chemical_list: D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D013956:Antithyroid Agents; D003276:Contraceptives, Oral; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007004:Hypoglycemic Agents