title: Toll-like receptors in neonatal sepsis.
abstract: Toll-like receptors are vital transmembrane receptors that initiate the innate immune response to many micro-organisms. The discovery of these receptors has improved our understanding of host-pathogen interactions, and these receptors play an important role in the pathogenesis of multiple neonatal conditions such as sepsis and brain injury. Toll-like receptors, especially TLRs 2 and 4, are associated with necrotizing enterocolitis, periventricular leukomalacia and sepsis.
  
  
  CONCLUSIONS
  Toll-like receptor modulation may potentially be used as immunomodulators in the management of neonatal sepsis.
authors: Department of Neonatology, National Maternity Hospital, Dublin, Ireland. fionaohare@physicians.ie
authors: Fiona M
authors: FM
authors: O'Hare
authors: R
authors: R
authors: William Watson
authors: Eleanor J
authors: EJ
authors: Molloy
mesh_terms: D000818:Animals; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007155:Immunologic Factors / Q000627:therapeutic use; D007231:Infant, Newborn; D009181:Mycoses / Q000276:immunology; D019936:Probiotics / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000382:microbiology*; D015398:Signal Transduction / Q000276:immunology; D051195:Toll-Like Receptor 2 / Q000276:immunology; D051197:Toll-Like Receptor 4 / Q000276:immunology; D051193:Toll-Like Receptors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*
chemical_list: D007155:Immunologic Factors; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors