title: HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer.
abstract: Increasing evidence has placed eukaryotic translation initiation factor 4E (eIF4E) at the hub of tumor development and progression. Several studies have reported that eIF4E is over-expressed in cervical cancer; however, the mechanism remains elusive. The results of this study further confirm over-expression of eIF4E in cervical cancer tumors and cell lines, and we have discovered that the transcription of eIF4E is induced by protein E6 of the human papillomavirus (HPV). Moreover, regulation of eIF4E by E6 significantly influences cell proliferation, the cell cycle, migration, and apoptosis. Therefore, eIF4E emerges as a key player in tumor development and progression and a potential target for CC treatment and prevention.
authors: Cancer Institute of Guangdong Medical College, No 1 Xincheng Road, Dongguan, Guangdong Province 523808, PR China.
authors: Sen
authors: S
authors: Wang
authors: Tianyun
authors: T
authors: Pang
authors: Min
authors: M
authors: Gao
authors: Haixian
authors: H
authors: Kang
authors: Weibin
authors: W
authors: Ding
authors: Xiwen
authors: X
authors: Sun
authors: Yi
authors: Y
authors: Zhao
authors: Wei
authors: W
authors: Zhu
authors: Xudong
authors: X
authors: Tang
authors: Yunhong
authors: Y
authors: Yao
authors: Xinrong
authors: X
authors: Hu
mesh_terms: D017209:Apoptosis; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D002453:Cell Cycle; D002465:Cell Movement; D049109:Cell Proliferation; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology / Q000821:virology; D015194:Diffusion Chambers, Culture; D039561:Eukaryotic Initiation Factor-4E / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D010957:Plasmids; D034741:RNA, Small Interfering / Q000235:genetics; D012097:Repressor Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic; D014162:Transfection; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000821:virology
chemical_list: C068651:E6 protein, Human papillomavirus type 16; D039561:Eukaryotic Initiation Factor-4E; D009856:Oncogene Proteins, Viral; D034741:RNA, Small Interfering; D012097:Repressor Proteins