title: Sinapyl alcohol derivatives from the lipo-soluble part of Dichrocephala benthamii C. B. Clarke.
abstract: Four new sinapyl alcohol derivatives dichrocephols A-D (compounds 1-4) were isolated from the lipo-soluble part of the whole herb of Dichrocephala benthamii C. B. Clarke, together with the known compound syringenin isovalerate (5). Their structures were elucidated on the basis of spectroscopic analysis. Their absolute configurations were established by the method of alkaline hydrohysis. Compounds 1-3 showed moderate cytotoxity against HeLa cells, with IC₅₀ values of 14.8 μM, 51.6 μM and 81.6 μM, respectively. This is the first time that sinapyl alcohol derivatives were isolated from the genus Dichrocephala.
authors: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
authors: Xinhui
authors: X
authors: Tian
authors: Gang
authors: G
authors: Ding
authors: Chaozhong
authors: C
authors: Peng
authors: Yanbao
authors: Y
authors: Hu
authors: Li
authors: L
authors: Li
authors: Hong
authors: H
authors: Chen
authors: Zhongmei
authors: Z
authors: Zou
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012995:Solubility
chemical_list: D008055:Lipids; D010666:Phenylpropionates; C496130:sinapyl alcohol