title: Deaths of tuberculosis patients in urban China: a retrospective cohort study.
abstract: BACKGROUND
  The case-fatality rate for tuberculosis (TB) remains high in China, whereas risk factors for deaths among TB cases are still unclear.
  
  
  METHODS
  This was a retrospective cohort study of all pulmonary TB patients registered in four districts of Shanghai from 2004 to 2008. Data were derived from the China National TB Surveillance System. A total of 4271 patients were followed up in communities. Data were analysed using Cox regression.
  
  
  RESULTS
  The percentage of all-cause deaths in the study population was 15% 2-6 years after the most recent TB diagnosis. TB was responsible for only 17% of all deaths; male sex was significantly associated with all-cause deaths. After adjustment for sex, age and treatment history, four factors were significantly and independently associated with increased risk of death: psychopathy, chronic bronchitis, cancer and the presence of multiple diseases. TB was responsible for 7.2 potential years of life lost (PYLL); PYLL was higher in females (8.2) than males (5.3).
  
  
  CONCLUSIONS
  TB remains a significant problem in urban China. Implementation of improved clinical management, prevention strategies and other public health programmes should target TB patients with chronic conditions, particularly those with multiple diseases.
authors: Department of Epidemiology, and Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China.
authors: W B
authors: WB
authors: Wang
authors: Q
authors: Q
authors: Zhao
authors: Z A
authors: ZA
authors: Yuan
authors: W L
authors: WL
authors: Jiang
authors: M L
authors: ML
authors: Liu
authors: B
authors: B
authors: Xu
mesh_terms: D000368:Aged; D029481:Bronchitis, Chronic / Q000401:mortality; D002423:Cause of Death; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000401:mortality; D015999:Multivariate Analysis; D009369:Neoplasms / Q000401:mortality; D016016:Proportional Hazards Models; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D014376:Tuberculosis / Q000401:mortality*; D014504:Urban Health / Q000706:statistics & numerical data*