title: Continuous synthesis and use of N-heterocyclic carbene copper(I) complexes from insoluble Cu2O.
abstract: It is demonstrated that homogeneous N-heterocyclic carbene-copper(I)-chloride complexes can be prepared continuously by flowing NHC precursors through a packed bed of solid Cu(2)O suspended in molecular sieves. The method enables the synthesis of a wide range of complexes including those that are challenging to prepare using standard approaches. Our strategy enables both sustained output of complex production for long-term catalytic reactions (greater than 5 h) and for generation of gram quantities for storage (greater than 1 g of complex in ~16 min).
authors: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, USA.
authors: Suzanne M
authors: SM
authors: Opalka
authors: Jin Kyoon
authors: JK
authors: Park
authors: Ashley R
authors: AR
authors: Longstreet
authors: D Tyler
authors: DT
authors: McQuade
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007093:Imidazoles; C030011:carbene; D003300:Copper; D008697:Methane; C000520:cuprous oxide