title: A randomized trial of the topical effect of antifibrinolytic epsilon aminocaproic Acid on coronary artery bypass surgery without cardiopulmonary bypass.
abstract: We assessed the effect of the topical application of epsilon-aminocaproic antifibrinolytic acid (EACA) on the pericardium of patients submitted to coronary artery bypass graft (CABG) without the use of cardiopulmonary bypass (CPB). This is a prospective, randomized, and double-blind study. We evaluated 26 patients with chronic coronary heart disease indicated for CABG without CPB (EACA and placebo groups). The analysis of the postoperative hematological results showed no difference between groups in hemoglobin and hematocrit. There was no difference between the groups regarding the postoperative bleeding through the drains in the first 24 hours, 48 hours, and accumulated loss until removal of drains. The use of EACA in patients undergoing CABG without CPB presented no difference in the reduction of the amount of bleeding and the need for blood transfusions.
authors: Disciplina de Cardiologia, Santo André, São Paulo, Brazil.
authors: Danilo Bortolotto
authors: DB
authors: Gurian
authors: Disciplina de Cardiologia, Santo André, São Paulo, Brazil.
authors: Adriano
authors: A
authors: Meneghini
authors: Laboratório de Escrita Científica, Santo André, São Paulo, Brazil.
authors: Luiz Carlos de
authors: LC
authors: Abreu
authors: Disciplina de Cardiologia, Santo André, São Paulo, Brazil.
authors: Neif
authors: N
authors: Murad
authors: Disciplina de Cardiologia, Santo André, São Paulo, Brazil.
authors: Leandro Luongo de
authors: LL
authors: Matos
authors: Departamento de Cirurgia, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.
authors: Adilson Casemiro
authors: AC
authors: Pires
authors: Programa de Pós-Graduação em Fisioterapia, Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista, UNESP, Presidente Prudente, São Paulo, Brasil.
authors: Vitor E
authors: VE
authors: Valenti
authors: Departamento de Cirurgia, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil bredajr@gmail.com.
authors: João Roberto
authors: JR
authors: Breda
mesh_terms: D000287:Administration, Topical; D000368:Aged; D015119:Aminocaproic Acid / Q000008:administration & dosage*; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium; D011446:Prospective Studies
chemical_list: D000933:Antifibrinolytic Agents; D015119:Aminocaproic Acid
keywords: antifibrinolytics; bypass; bypass surgery; cardiopulmonary; coronary artery; coronary artery bypass