title: Effects on bone union and prevention of tendon adhesion by new porous anti-adhesive poly L-lactide-co-ε-caprolactone membrane in a rabbit model.
abstract: To prevent adhesion between the tendon and the plate in hand surgery, a porous poly L-lactide-co-ε-caprolactone (P(LA/CL)) membrane was developed as a biologically absorbable anti-adhesion material. Our study aims to confirm the efficacy of this new P(LA/CL) membrane and its influences on the osteotomy site by performing a fundamental experiment assessing the possibility of clinical application.   We prepared a rabbit model of tendon-plate adhesion, and evaluated the efficacy of the P(LA/CL) membrane to pullout tendon strength, to be scored in terms of macroscopic, pathological results. Another rabbit model of osteotomy was prepared to confirm the P(LA/CL) membrane influences on bone union by radiological, mechanical and pathological evaluation. The result showed to be significantly lower adhesion in the P(LA/CL) membrane group than in the control group. Also there were no differences between the P(LA/CL) membrane group and control group in the results for bone union.
authors: Department of Orthopaedic Surgery, St. Marianna University School of Medicine, Kanagawa, Japan. satotaku@kg8.so-net.ne.jp
authors: Takuya
authors: T
authors: Sato
authors: Hiroyuki
authors: H
authors: Shimizu
authors: Moroe
authors: M
authors: Beppu
authors: Masayuki
authors: M
authors: Takagi
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002208:Caproates; D004195:Disease Models, Animal; D017102:Fracture Healing / Q000187:drug effects*; D050723:Fractures, Bone / Q000473:pathology / Q000601:surgery*; D007783:Lactones; D008422:Materials Testing; D008567:Membranes, Artificial; D019637:Orthopedic Procedures / Q000379:methods; D011817:Rabbits; D013708:Tendon Injuries / Q000473:pathology / Q000601:surgery*; D013710:Tendons / Q000473:pathology* / Q000601:surgery; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*
chemical_list: D001672:Biocompatible Materials; D002208:Caproates; D007783:Lactones; D008567:Membranes, Artificial; C121056:caprolactone