title: Paediatric normative data for urine NGAL/creatinine ratio.
abstract: OBJECTIVE
  The objective of this study was to establish age-dependent urine NGAL (neutrophil gelatinase-associated lipocalin)/creatinine ratio values in healthy children and adolescents.
  
  
  METHODS
  The study was performed using a random sample of 172 healthy children and adolescents (M-88, F-84), aged median 9.75 (0.2-17.9) years. Urine NGAL concentration was measured using a commercially available ELISA kit (R&D Systems, USA).
  
  
  RESULTS
  Median concentrations of urine NGAL/creatinine in particular age groups were analysed using anova. The differences between the youngest group of children under the age of 6 years and the rest of examined population were statistically significant. There were no differences in urine NGAL/creatinine between other age groups. Statistically significant negative correlation between urine NGAL/creatinine and age of subjects was found (r = -0.29, p < 0.05).
  
  
  CONCLUSIONS
  In the study, normative values of urine NGAL/creatinine for subjects aged 0.2-17.9 years have been established. These data may help clinicians and researchers to improve the interpretation of urine NGAL/creatinine ratio in children and adolescents. However, further studies using numerous data should be conducted to add reference values for urine NGAL partitioned by age and gender.
authors: Department of Pediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland. arszuminska@gmail.com
authors: Agnieszka
authors: A
authors: Rybi-Szumińska
authors: Anna
authors: A
authors: Wasilewska
authors: Miecyslaw
authors: M
authors: Litwin
authors: Zbigniew
authors: Z
authors: Kułaga
authors: Michal
authors: M
authors: Szumiński
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D007223:Infant; D000071068:Lipocalin-2; D054834:Lipocalins / Q000032:analysis*; D008297:Male; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D012016:Reference Values
chemical_list: D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine