title: Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18.
abstract: CREB binding protein (CBP) is an acetyltransferase that plays an important role in many biological processes. Here, we show that Akt phosphorylates CBP at threonine 1871 and suppresses its acetyltransferase activity by impeding the binding of CBP to histone H3, which results in a decrease in lysine K18 acetylation and dysregulation of target genes. Our results demonstrate that Akt regulates acetyltransferase activity through CBP phosphorylation, which may contribute to tumorigenesis.
authors: College of Life Sciences, Hebei United University, Tangshan 063000, China. yan.liu68@yahoo.cn
authors: Yan
authors: Y
authors: Liu
authors: Zhao-bin
authors: ZB
authors: Xing
authors: Jing-hua
authors: JH
authors: Zhang
authors: Yue
authors: Y
authors: Fang
mesh_terms: D000107:Acetylation; D000818:Animals; D015153:Blotting, Western; D050882:CREB-Binding Protein / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D045744:Cell Line, Tumor; D020869:Gene Expression Profiling; D006367:HeLa Cells; D051548:Histone Acetyltransferases / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000235:genetics / Q000378:metabolism*; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D009154:Mutation; D009374:Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D013379:Substrate Specificity; D013912:Threonine / Q000235:genetics / Q000378:metabolism; D014183:Transplantation, Heterologous
chemical_list: D006657:Histones; D013912:Threonine; D050882:CREB-Binding Protein; D051548:Histone Acetyltransferases; D051057:Proto-Oncogene Proteins c-akt; D008239:Lysine