title: Gelatin-alginate gels and their enzymatic modifications: controlling the delivery of small molecules.
abstract: The release of molecules entrapped within biogels is dictated by diffusion laws. Innovative biogel architectures are conceived and tested to control small molecule delivery from gelatin gels. The ionic interactions modulate the release of small molecules. Alginate is then added to gelatin gels and further hydrolyzed; the influence of viscosity is discussed. Next, various mixed gels are compared, such as a gelatin-alginate IPN and the original architecture of an alginate gel entrapped in a gelatin gel with or without a polysaccharidase. The relative influence of ionic interactions and diffusional constraints on the delivery of small charged molecules is explored, and a solution for controlling diffusion is proposed for any situation.
authors: ERRMECe Lab., Université de Cergy-Pontoise, i-MAT, PRES UPGO, BP222-95000 Cergy Pontoise, France.
authors: Marie-Cécile
authors: MC
authors: Klak
authors: Elodie
authors: E
authors: Lefebvre
authors: Laure
authors: L
authors: Rémy
authors: Rémy
authors: R
authors: Agniel
authors: Julien
authors: J
authors: Picard
authors: Sébastien
authors: S
authors: Giraudier
authors: Véronique
authors: V
authors: Larreta-Garde
mesh_terms: D000464:Alginates / Q000378:metabolism*; D000818:Animals; D001979:Bromthymol Blue / Q000378:metabolism; D004396:Coloring Agents / Q000378:metabolism*; D004058:Diffusion; D016503:Drug Delivery Systems; D055119:Elastic Modulus; D004801:Eosine Yellowish-(YS) / Q000378:metabolism; D005780:Gelatin / Q000378:metabolism*; D005782:Gels / Q000378:metabolism*; D020723:Glucuronic Acid / Q000378:metabolism; D006603:Hexuronic Acids / Q000378:metabolism; D007477:Ions; D008751:Methylene Blue / Q000378:metabolism; D008863:Microspheres; D011133:Polysaccharide-Lyases / Q000378:metabolism*; D011134:Polysaccharides / Q000737:chemistry; D034421:Sus scrofa; D013997:Time Factors
chemical_list: D000464:Alginates; D004396:Coloring Agents; D005782:Gels; D006603:Hexuronic Acids; D007477:Ions; D011134:Polysaccharides; D020723:Glucuronic Acid; D005780:Gelatin; D011133:Polysaccharide-Lyases; C016158:poly(beta-D-mannuronate) lyase; D008751:Methylene Blue; D004801:Eosine Yellowish-(YS); D001979:Bromthymol Blue