title: Expected years of life lost for six potentially preventable cancers in the United States.
abstract: OBJECTIVE
  This study aimed to quantify the reduced life expectancy for six types of potentially preventable cancer in the United States.
  
  
  METHODS
  A total of 1,579,310 patients diagnosed with cancers of the lung, colon and rectum, liver, breast, cervix, or prostate in 1992-2005 were identified from the Surveillance, Epidemiology, and End Results registries. The lifetime survival functions for the cancer cohort and age-/sex-matched reference population were generated using a semi-parametric extrapolation method with annual life tables. The average expected years of life lost (EYLL) for cancers were calculated by subtracting the estimated life expectancy of the cancer cohorts from that of the reference population.
  
  
  RESULTS
  Liver cancer and lung cancer had an average EYLL of over 13 years, while the EYLL for prostate cancer was below 2 years. When considering the annual incidence in 2012, lung cancer would cause the greatest subtotal of EYLL (3,116,000 years) followed by female breast cancer (1,420,000 years) and colorectal cancer (932,000 years).
  
  
  CONCLUSIONS
  The potential life years saved by successful prevention, in terms of EYLL since diagnosis, would be substantial for lung cancer, breast cancer, and colorectal cancer. This work will inform prioritization of strategies for cancer control to minimize the life expectancy loss.
authors: Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA. phliu@hcp.med.harvard.edu
authors: Pang-Hsiang
authors: PH
authors: Liu
authors: Jung-Der
authors: JD
authors: Wang
authors: Nancy L
authors: NL
authors: Keating
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality* / Q000517:prevention & control; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000401:mortality* / Q000517:prevention & control; D005260:Female; D006293:Health Promotion; D006801:Humans; D008017:Life Expectancy; D015993:Life Tables; D008113:Liver Neoplasms / Q000401:mortality* / Q000517:prevention & control; D008175:Lung Neoplasms / Q000401:mortality* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality* / Q000517:prevention & control; D011471:Prostatic Neoplasms / Q000401:mortality* / Q000517:prevention & control; D018426:SEER Program; D014481:United States / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000517:prevention & control; D055815:Young Adult