title: Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population.
abstract: We examined the relationship between PAH-DNA adduct levels in the placental tissue, measured by a highly sensitive (32)P-postlabeling assay, and the risk of fetal neural tube defects (NTDs). We further explored the interaction between PAH-DNA adducts and placental PAHs with respect to NTD risk. Placental tissues from 80 NTD-affected pregnancies and 50 uncomplicated normal pregnancies were included in this case-control study. Levels of PAH-DNA adducts were lower in the NTD group (8.12 per 10(8) nucleotides) compared to controls (9.92 per 10(8) nucleotides). PAH-DNA adduct concentrations below the median was associated with a 3-fold increased NTD risk. Women with a low PAH-DNA adduct level in concert with a high placental PAH level resulted in a 10-fold elevated risk of having an NTD-complicated pregnancy. A low level of placental PAH-DNA adducts was associated with an increased risk of NTDs; this risk increased dramatically when a low adduct level was coupled with a high placental PAH concentration.
authors: Department of Epidemiology and Health Statistics, School of Public Health, Peking University, Beijing 100191, China.
authors: Yue
authors: Y
authors: Yuan
authors: Lei
authors: L
authors: Jin
authors: Linlin
authors: L
authors: Wang
authors: Zhiwen
authors: Z
authors: Li
authors: Le
authors: L
authors: Zhang
authors: Huiping
authors: H
authors: Zhu
authors: Richard H
authors: RH
authors: Finnell
authors: Guodong
authors: G
authors: Zhou
authors: Aiguo
authors: A
authors: Ren
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D018736:DNA Adducts / Q000378:metabolism*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000032:analysis; D005260:Female; D006801:Humans; D009436:Neural Tube Defects / Q000453:epidemiology* / Q000378:metabolism; D010920:Placenta / Q000737:chemistry / Q000378:metabolism*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000378:metabolism*; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D018736:DNA Adducts; D004785:Environmental Pollutants; D011084:Polycyclic Aromatic Hydrocarbons; C095911:polycyclic aromatic hydrocarbons-DNA adduct