title: Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin'?
abstract: Neurons rely on their cytoskeleton to give them shape and stability, and on cytoskeletal dynamics for growth and synaptic plasticity. Because drug addiction is increasingly seen as the inappropriate learning of strongly reinforcing stimuli, the role of the cytoskeleton in shaping drug memories has been of increasing interest in recent years. Does the cytoskeleton have an active role in shaping these memories, and to what extent do alterations in the cytoskeleton reflect the acute actions of drug exposure, or homeostatic reactions to the chronic exposure to drugs of abuse? Here we will review recent advances in understanding the role of the cytoskeleton in the development of drug addiction, with a focus on actin filaments, as they have been studied in greater detail.
authors: Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, United States. adrian.rothenfluh@utsouthwestern.edu
authors: Adrian
authors: A
authors: Rothenfluh
authors: Christopher W
authors: CW
authors: Cowan
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000473:pathology; D003042:Cocaine / Q000494:pharmacology; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D003599:Cytoskeleton / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D013287:Illicit Drugs / Q000494:pharmacology*; D019966:Substance-Related Disorders / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
chemical_list: D003598:Cytoskeletal Proteins; D013287:Illicit Drugs; D000431:Ethanol; D003042:Cocaine