title: Hydroxyl radical induced degradation of ibuprofen.
abstract: Pulse radiolysis experiments were used to characterize the intermediates formed from ibuprofen during electron beam irradiation in a solution of 0.1mmoldm(-3). For end product characterization (60)Co γ-irradiation was used and the samples were evaluated either by taking their UV-vis spectra or by HPLC with UV or MS detection. The reactions of OH resulted in hydroxycyclohexadienyl type radical intermediates. The intermediates produced in further reactions hydroxylated the derivatives of ibuprofen as final products. The hydrated electron attacked the carboxyl group. Ibuprofen degradation is more efficient under oxidative conditions than under reductive conditions. The ecotoxicity of the solution was monitored by Daphnia magna standard microbiotest and Vibrio fischeri luminescent bacteria test. The toxic effect of the aerated ibuprofen solution first increased upon irradiation indicating a higher toxicity of the first degradation products, then decreased with increasing absorbed dose.
authors: Institute of Chemistry, Research Group of Environmental Chemistry, University of Szeged, Szeged, Hungary. erzsebet.illes@chem.u-szeged.hu
authors: Erzsébet
authors: E
authors: Illés
authors: Erzsébet
authors: E
authors: Takács
authors: András
authors: A
authors: Dombi
authors: Krisztina
authors: K
authors: Gajda-Schrantz
authors: Gergely
authors: G
authors: Rácz
authors: Katalin
authors: K
authors: Gonter
authors: László
authors: L
authors: Wojnárovits
mesh_terms: D048908:Aliivibrio fischeri / Q000187:drug effects; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003621:Daphnia / Q000187:drug effects; D054750:Ecotoxicology / Q000379:methods; D005720:Gamma Rays; D017665:Hydroxyl Radical / Q000737:chemistry*; D006900:Hydroxylation; D007052:Ibuprofen / Q000737:chemistry* / Q000528:radiation effects / Q000633:toxicity; D049449:Luminescence; D013058:Mass Spectrometry; D011675:Pulse Radiolysis; D012996:Solutions / Q000633:toxicity; D013056:Spectrophotometry, Ultraviolet; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000633:toxicity
chemical_list: D012996:Solutions; D014874:Water Pollutants, Chemical; D017665:Hydroxyl Radical; D007052:Ibuprofen