title: Intermediate-term outcomes after combined heart-liver transplantation in children with a univentricular heart.
abstract: For patients with end-stage hepatic failure secondary to failing hemodynamics, combined heart-liver transplant (H-LT) remains the only option for long-term survival. We report a series of three pediatric patients who successfully underwent orthotopic H-LT for failed single-ventricle palliation. All three patients are currently living, now two, three, and five years post-transplant, and remain completely free of cardiac cellular allograft rejection despite reduced immunosuppression protocols. One patient, however, did develop acute antibody-mediated rejection in the immediate post-transplant period, suggesting that this protective effect may be less effective in attenuating humoral mechanisms of rejection.
authors: Department of Pediatrics, Division of Cardiology, Stanford University Medical Center, Palo Alto, CA 94304, USA. seth.hollander@stanford.edu
authors: Seth A
authors: SA
authors: Hollander
authors: Olaf
authors: O
authors: Reinhartz
authors: Katsuhide
authors: K
authors: Maeda
authors: Melissa
authors: M
authors: Hurwitz
authors: David
authors: D
authors: N Rosenthal
authors: Daniel
authors: D
authors: Bernstein
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000601:surgery*; D016027:Heart Transplantation / Q000379:methods; D006352:Heart Ventricles / Q000002:abnormalities* / Q000601:surgery*; D006801:Humans; D017093:Liver Failure / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods; D008297:Male; D013997:Time Factors; D016896:Treatment Outcome