title: Human T cell lymphotropic virus type 1 infection among U.S. thalassemia patients.
abstract: Thalassemia is an inherited genetic disorder requiring multiple transfusions to treat anemia caused by low hemoglobin levels. Thus, thalassemia patients are at risk for infection with blood-borne pathogens, including human T cell lymphotropic viruses (HTLV) that are transmitted by transfusion of cellular blood products. Here, we examined the prevalence of HTLV among 234 U.S. thalassemia patients using sera collected in 2008. Sera were tested for antibodies to HTLV-1/2 using enzyme immunoassay (EIA) and a confirmatory western blot (WB) that differentiates between HTLV-1 and HTLV-2. Demographic information and clinical information were collected at study enrollment, including HIV and hepatitis C virus (HCV) status. Three patients (1.3%) were WB positive; two were HTLV-1 and one could not be serotyped as HTLV-1/2. All three HTLV-positive persons were HIV-1 negative and one was HCV seropositive. The HTLV seroprevalence was higher than that of HIV-1 (0.85%) and lower than HCV (18.8%) in this population. All three patients (ages 26-46 years) were diagnosed with β-thalassemia shortly after birth and have since been receiving multiple transfusions annually. Two of the HTLV-positive patients confirmed receiving transfusions before HTLV blood screening was implemented in 1988. We identified a substantial HTLV-1 seroprevalence in U.S. thalassemia patients that is much greater than that seen in blood donors. Our findings highlight the importance of HTLV testing of patients with thalassemia and other diseases requiring multiple transfusions, especially in recipients of unscreened transfusions. In addition, appropriate counseling and follow-up of HTLV-infected patients are warranted.
authors: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. bis3@cdc.gov
authors: William M
authors: WM
authors: Switzer
authors: Anupama
authors: A
authors: Shankar
authors: Sean R
authors: SR
authors: Trimble
authors: Alexis A
authors: AA
authors: Thompson
authors: Patricia J
authors: PJ
authors: Giardina
authors: Alan R
authors: AR
authors: Cohen
authors: Thomas D
authors: TD
authors: Coates
authors: Elliott
authors: E
authors: Vichinsky
authors: Ellis J
authors: EJ
authors: Neufeld
authors: Jeanne M
authors: JM
authors: Boudreaux
authors: Walid
authors: W
authors: Heneine
mesh_terms: D000328:Adult; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood; D015490:HTLV-I Infections / Q000150:complications* / Q000453:epidemiology / Q000635:transmission; D015491:HTLV-II Infections / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D065227:Transfusion Reaction; D014481:United States / Q000453:epidemiology; D017085:alpha-Thalassemia / Q000150:complications; D017086:beta-Thalassemia / Q000150:complications*
chemical_list: D015481:HTLV-I Antibodies