title: Neuronal migration defect of the developing cerebellar vermis in substrains of C57BL/6 mice: cytoarchitecture and prevalence of molecular layer heterotopia.
abstract: Abnormal development of the cerebellum is often associated with disorders of movement, postural control, and motor learning. Rodent models are widely used to study normal and abnormal cerebellar development and have revealed the roles of many important genetic and environmental factors. In the present report we describe the prevalence and cytoarchitecture of molecular-layer heterotopia, a malformation of neuronal migration, in the cerebellar vermis of C57BL/6 mice and closely-related strains. In particular, we found a diverse number of cell-types affected by these malformations including Purkinje cells, granule cells, inhibitory interneurons (GABAergic and glycinergic), and glia. Heterotopia were not observed in a sample of wild-derived mice, outbred mice, or inbred mice not closely related to C57BL/6 mice. These data are relevant to the use of C57BL/6 mice as models in the study of brain and behavior relationships and provide greater understanding of human cerebellar dysplasia.
authors: Department of Neuroscience and Histology, New York College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, N.Y., USA.
authors: Zareema
authors: Z
authors: Mangaru
authors: Elsaid
authors: E
authors: Salem
authors: Matthew
authors: M
authors: Sherman
authors: Sarah E
authors: SE
authors: Van Dine
authors: Ankur
authors: A
authors: Bhambri
authors: Joshua C
authors: JC
authors: Brumberg
authors: Eric K
authors: EK
authors: Richfield
authors: Lisa A
authors: LA
authors: Gabel
authors: Raddy L
authors: RL
authors: Ramos
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000002:abnormalities* / Q000254:growth & development; D054081:Malformations of Cortical Development, Group II / Q000453:epidemiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D015995:Prevalence