title: How molecular testing can help (and hurt) in the workup of gliomas.
abstract: Advances in genetics research have greatly expanded our ability to accurately diagnose gliomas and provide more useful prognostic information. Herein specific examples are used to show how high-yield targets such as EGFR, 1p/19q, IDH1/2, MGMT, and BRAF can expand the power of the surgical neuropathologist. To avoid errors, however, the significance and controversies associated with each test must be thoroughly understood.
authors: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors: Kenneth
authors: K
authors: Clark
authors: Zoya
authors: Z
authors: Voronovich
authors: Craig
authors: C
authors: Horbinski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D005910:Glioma / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008967:Molecular Biology / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor