title: Management of pediatric spinal cord astrocytomas: outcomes with adjuvant radiation.
abstract: OBJECTIVE
  Pediatric intramedullary spinal cord tumors are exceedingly rare; in the United States, 100 to 200 cases are recognized annually, of these, most are astrocytomas. The purpose of this study is to report the outcomes in pediatric patients with spinal cord astrocytomas treated at a tertiary care center.
  
  
  METHODS
  An institutional review board-approved retrospective single-institution study was performed for pediatric patients with spinal cord astrocytomas treated at our hospital from 1990 to 2010. The patients were evaluated on the extent of resection, progression-free survival (PFS), and development of radiation-related toxicities. Kaplan-Meier curves and multivariate regression model methods were used for analysis.
  
  
  RESULTS
  Twenty-nine patients were included in the study, 24 with grade 1 or 2 (low-grade) tumors and 5 with grade 3 or 4 (high-grade) tumors. The median follow-up time was 55 months (range, 1-215 months) for patients with low-grade tumors and 17 months (range, 10-52 months) for those with high-grade tumors. Thirteen patients in the cohort received chemotherapy. All patients underwent at least 1 surgical resection. Twelve patients received radiation therapy to a median radiation dose of 47.5 Gy (range, 28.6-54.0 Gy). Fifteen patients with low-grade tumors and 1 patient with a high-grade tumor exhibited stable disease at the last follow-up visit. Acute toxicities of radiation therapy were low grade, whereas long-term sequelae were infrequent and manageable when they arose. All patients with low-grade tumors were alive at the last follow-up visit, compared with 1 patient with a high-grade tumor.
  
  
  CONCLUSIONS
  Primary pediatric spinal cord astrocytomas vary widely in presentation and clinical course. Histopathologic grade remains a major prognostic factor. Patients with low-grade tumors tend to have excellent disease control and long-term survival compared to those with high-grade tumors. This experience suggests that radiation therapy may enhance tumor control with an acceptably low risk of long-term sequelae in this sensitive patient population.
authors: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Hospital, Baltimore, Maryland, USA.
authors: Zachary D
authors: ZD
authors: Guss
authors: Shalini
authors: S
authors: Moningi
authors: George I
authors: GI
authors: Jallo
authors: Kenneth J
authors: KJ
authors: Cohen
authors: Moody D
authors: MD
authors: Wharam
authors: Stephanie A
authors: SA
authors: Terezakis
mesh_terms: D000293:Adolescent; D001254:Astrocytoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D015142:Baltimore; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D011832:Radiation Injuries / Q000150:complications / Q000473:pathology; D011879:Radiotherapy Dosage; D012044:Regression Analysis; D012189:Retrospective Studies; D013120:Spinal Cord Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D062606:Tertiary Care Centers; D016896:Treatment Outcome; D055815:Young Adult