title: Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.
abstract: Epithelial-mesenchymal transition (EMT) and the reverse process, mesenchymal-epithelial transition (MET), are essential during development and in the regulation of stem cell pluripotency, yet these processes are also activated in pathological contexts, such as in fibrosis and cancer progression. In EMT and MET, diverse signaling pathways cooperate in the initiation and progression of the EMT and MET programs, through regulation at transcriptional, post-transcriptional, translational, and post-translational levels. MicroRNAs recently emerged as potent regulators of EMT and MET, with their abilities to target multiple components involved in epithelial integrity or mesenchymal traits. By affecting EMT and MET processes, microRNAs are involved in the regulation of stem cell pluripotency and the control of tumor progression.
authors: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, United States.
authors: Samy
authors: S
authors: Lamouille
authors: Deepa
authors: D
authors: Subramanyam
authors: Robert
authors: R
authors: Blelloch
authors: Rik
authors: R
authors: Derynck
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000473:pathology; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors