title: Association of exposure to phenols and idiopathic male infertility.
abstract: Widespread human exposure to phenols has been documented recently, and some phenols which are potential endocrine disruptors have demonstrated adverse effects on male reproduction in animal and in vitro studies. However, implications about exposure to phenols and male infertility are scarce in humans. Case-control study of 877 idiopathic infertile men and 713 fertile controls was conducted. Urinary levels of bisphenol A, benzophenone-3, pentachlorophenol, triclosan, 4-tert-octylphenol (4-t-OP), 4-n-octylphenol (4-n-OP) and 4-n-nonylphenol (4-n-NP) and semen parameters were measured. After multivariate adjustment, we found 4-t-OP, 4-n-OP and 4-n-NP exposure was associated with idiopathic male infertility (p-value for trend: <0.0001, 0.014 and 0.001, respectively). Aside from these associations, 4-t-OP and 4-n-NP exposure was also associated with idiopathic male infertility with abnormal semen parameters. Moreover, we observed significant associations between sum alkylphenols (APs) exposure and idiopathic male infertility. There were no relationships between exposure to other phenols and idiopathic male infertility in the present study. Our study provides the first evidence that exposure to APs (4-t-OP, 4-n-OP and 4-n-NP) is associated with idiopathic male infertility.
authors: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China.
authors: Minjian
authors: M
authors: Chen
authors: Rong
authors: R
authors: Tang
authors: Guangbo
authors: G
authors: Fu
authors: Bin
authors: B
authors: Xu
authors: Pengfei
authors: P
authors: Zhu
authors: Shanlei
authors: S
authors: Qiao
authors: Xiaojiao
authors: X
authors: Chen
authors: Bo
authors: B
authors: Xu
authors: Yufeng
authors: Y
authors: Qin
authors: Chuncheng
authors: C
authors: Lu
authors: Bo
authors: B
authors: Hang
authors: Yankai
authors: Y
authors: Xia
authors: Xinru
authors: X
authors: Wang
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000652:urine; D001577:Benzophenones / Q000652:urine; D016022:Case-Control Studies; D005298:Fertility; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced* / Q000652:urine*; D008297:Male; D016017:Odds Ratio; D010416:Pentachlorophenol / Q000652:urine; D010636:Phenols / Q000009:adverse effects* / Q000652:urine; D012661:Semen / Q000187:drug effects; D014260:Triclosan / Q000652:urine; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D001577:Benzophenones; D010416:Pentachlorophenol; D010636:Phenols; D014260:Triclosan; C080417:4-octylphenol; C005290:oxybenzone; C041594:4-nonylphenol; C105260:4-tert-octylphenol; C006780:bisphenol A; D000098826:Bisphenol A Compounds