title: Associations between body size and serum estradiol and sex hormone-binding globulin levels in premenopausal African American women.
abstract: BACKGROUND
  African American (AA) women have the highest rates of premenopausal breast cancer; however, it is unclear whether body size contributes to the hormonal patterns potentially associated with increased breast cancer risk in these women.
  
  
  OBJECTIVE
  To characterize the association between body size and serum levels of estradiol and sex hormone-binding globulin (SHBG) levels in a sample of premenopausal AA women.
  
  
  METHODS
  A total of 164 premenopausal AA women who were not pregnant or breastfeeding were recruited for this study. Serum samples were collected during the early follicular phase, and trained staff collected body size measurements. Multiple linear regression models were performed to assess potential associations.
  
  
  METHODS
  Serum estradiol and SHBG levels.
  
  
  RESULTS
  Many (81%) of the women enrolled were overweight or obese. Both waist-to-hip ratio (WHR) (β = 2.68, P = .008) and waist circumference (WC) (β = 2.02, P = .046) were positively associated with higher levels of estradiol. All measures of body was significantly and inversely associated with SHBG levels (all P < .05).
  
  
  CONCLUSIONS
  Premenopausal AA women with higher WHR or larger WC may have higher levels of estradiol and lower levels of SHBG. Thus, WHR or WC may be better indicators for assessing hormonal patterns implicated in breast cancer pathogenesis in these women.
authors: The Dorothy I. Height Center for Health Equity and Evaluation Research (CHEER), University of Houston and The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit #1440, Houston, Texas 77030, USA. rjpaxton@mdanderson.org
authors: Raheem J
authors: RJ
authors: Paxton
authors: Denae W
authors: DW
authors: King
authors: Celia
authors: C
authors: Garcia-Prieto
authors: Shahnjayla K
authors: SK
authors: Connors
authors: Mike
authors: M
authors: Hernandez
authors: Beverly J
authors: BJ
authors: Gor
authors: Lovell A
authors: LA
authors: Jones
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D050218:Body Fat Distribution / Q000706:statistics & numerical data; D049628:Body Size; D001943:Breast Neoplasms / Q000208:ethnology* / Q000378:metabolism; D004958:Estradiol / Q000097:blood*; D005260:Female; D005498:Follicular Phase / Q000208:ethnology / Q000378:metabolism; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology / Q000378:metabolism; D050177:Overweight / Q000208:ethnology / Q000378:metabolism; D017697:Premenopause / Q000208:ethnology* / Q000378:metabolism; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D049629:Waist-Hip Ratio / Q000706:statistics & numerical data
chemical_list: D012738:Sex Hormone-Binding Globulin; D004958:Estradiol