title: Scalable technology for the extraction of pharmaceutics: outcomes from a 3 year collaborative industry/academia research programme.
abstract: This paper reports on some of the key outcomes of a 3 year £1.5m Technology Strategy Board (TSB) funded research programme to develop a small footprint, versatile, counter-current chromatography purification technology and methodology which can be operated at a range of scales in both batch and continuous modes and that can be inserted into existing process plant and systems. Our consortium, integrates technology providers (Dynamic Extractions) and the scientific development team (Brunel) with end user needs (GSK & Pfizer), addressing major production challenges aimed at providing flexible, low capital platform technology driving substantial cost efficiency in both drug development and drug manufacturing processes. The aims of the Technology Strategy Board's high value manufacturing programme are described and how the academic/industry community were challenged to instigate step changes in the manufacturing of high value pharmaceuticals. This paper focusses on one of the themes of the TSB research programme, "Generate a Comprehensive Applications Portfolio". It outlines 15 applications from this portfolio that can be published in the public domain and gives four detailed case studies illustrating the range of application of the technology on the separation of (1) isomers, (2) polar compounds, (3) crude mixtures and (4) on the removal of impurities. Two of these case studies that were scaled up demonstrate between 10 and 20% lower solvent usage and were projected to have significant cost savings compared to conventional solid phase silica gel chromatography at procss scale demonstrating that the latest high performance countercurrent chromatography technology is a competitive platform technolgy for the pharmaceutical industry.
authors: Brunel Institute for Bioengineering, Brunel University, Uxbridge UB8 3PH, UK. ian.sutherland@brunel.ac.uk
authors: Ian
authors: I
authors: Sutherland
authors: Chris
authors: C
authors: Thickitt
authors: Nathalie
authors: N
authors: Douillet
authors: Keith
authors: K
authors: Freebairn
authors: David
authors: D
authors: Johns
authors: Clive
authors: C
authors: Mountain
authors: Philip
authors: P
authors: Wood
authors: Neil
authors: N
authors: Edwards
authors: David
authors: D
authors: Rooke
authors: Guy
authors: G
authors: Harris
authors: David
authors: D
authors: Keay
authors: Ben
authors: B
authors: Mathews
authors: Roland
authors: R
authors: Brown
authors: Ian
authors: I
authors: Garrard
authors: Peter
authors: P
authors: Hewitson
authors: Svetlana
authors: S
authors: Ignatova
mesh_terms: D003377:Countercurrent Distribution / Q000379:methods*; D004345:Drug Industry; D007536:Isomerism; D008956:Models, Chemical; D009930:Organic Chemicals / Q000302:isolation & purification; D004364:Pharmaceutical Preparations / Q000302:isolation & purification*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D009930:Organic Chemicals; D004364:Pharmaceutical Preparations