title: Expression and potential role of GATA factors in trophoblast development.
abstract: Despite exhaustive studies, molecular mechanisms governing blastocyst formation, implantation to the uterine endometrium and placentation have not been definitively characterized. GATA family proteins are a group of zinc finger transcription factors, for which gene ablations eventually result in embryonic death later in pregnancy. These findings suggested that GATA factors are not essential for early embryonic development. However, recent studies from our laboratory and others have revealed that GATA proteins are involved in the regulation of key genes expressed by the trophectoderm that underpin the transition from the morula to trophoblast, and trophectoderm maintenance. Consequently, it is important to consider the current understanding how GATA factors govern early trophectoderm development.
authors: Laboratory of Animal Breeding, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo 113-8657, Japan.
authors: Hanako
authors: H
authors: Bai
authors: Toshihiro
authors: T
authors: Sakurai
authors: James D
authors: JD
authors: Godkin
authors: Kazuhiko
authors: K
authors: Imakawa
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D047108:Embryonic Development / Q000235:genetics; D005260:Female; D050980:GATA Transcription Factors / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D011247:Pregnancy; D011270:Pregnancy, Animal; D014158:Transcription, Genetic; D014327:Trophoblasts / Q000502:physiology*
chemical_list: D050980:GATA Transcription Factors