title: Daily vs every other day administration of G-CSF following autologous peripheral stem cell transplantation: a prospective randomized study.
abstract: The purpose of the study was to evaluate whether every other day administration of G-CSF was as safe and efficient as daily administration of G-CSF on neutrophil engraftment following autologous peripheral stem cell transplantation (APSCT). Duration of G-CSF administration, incidence of blood stream infections, duration of febrile neutropenia, duration of non-prophylactic antibiotic therapy, transfusion requirements, duration of hospitalization and G-CSF costs were also studied. Forty-seven patients with diagnosis of lymphoma and multiple myeloma undergoing APSCT were randomized to receive post-transplant daily or every other day G-CSF therapy both beginning on day +1. Both groups were comparable with regard to patient characteristics. There was no significant difference in time to neutrophil engraftment (p=0.31). The duration of G-CSF administration was significantly less in the every other day group (p<0.001). There were no detectable differences seen in the number of febrile days, duration of non-prophylactic antibiotics, the incidence of blood stream infections, transfusion requirements and the duration of hospitalization. There was a trend towards a faster platelet recovery in the every other day group, although the difference was not statistically significant (p=0.059). The number of doses of G-CSF used per transplant is significantly reduced, resulting in a significant reduction in drug costs.
authors: Anadolu Medical Center Hospital, Bone Marrow Transplantation Center, Cumhuriyet Mah. 2255 sk. No. 3, Gebze 41400, Kocaeli, Turkey.
authors: Hasan Atilla
authors: HA
authors: Ozkan
authors: Ufuk Guney
authors: UG
authors: Ozer
authors: Cengiz
authors: C
authors: Bal
authors: Zafer
authors: Z
authors: Gulbas
mesh_terms: D000328:Adult; D000368:Aged; D064592:Autografts; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000191:economics; D006801:Humans; D007239:Infections / Q000188:drug therapy / Q000191:economics / Q000209:etiology; D007902:Length of Stay / Q000191:economics; D008223:Lymphoma / Q000191:economics / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000191:economics / Q000628:therapy*; D011446:Prospective Studies; D033581:Stem Cell Transplantation; D013997:Time Factors
chemical_list: D016179:Granulocyte Colony-Stimulating Factor
keywords: Autologous peripheral stem cell transplantation; Every other day administration; Granulocyte-colony stimulating factor; Hematopoietic recovery