title: The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments.
abstract: Neuropsychiatric symptoms (NPS) affect the quality of life of patients with dementia and increase the burden on caregivers. We aimed to evaluate how small vessel disease (SVD) such as lacunae or white matter hyperintensities (WMH), and amyloid burden affect NPS. We recruited 127 patients with subcortical vascular cognitive impairment who were assessed with brain magnetic resonance imaging, Pittsburgh compound-B (PiB) positron emission tomography and the neuropsychiatric inventory (NPI). To explore the association between lacunae, WMH, or PiB retention ratio and NPS, we performed multivariate regression analysis after controlling for possible confounders. Each additional lacuna, especially in the frontal region, was associated with higher odds of depression, apathy, aberrant motor behavior, nighttime behavior, appetite changes, and higher score of total NPI; larger WMH volume, especially in the frontal region, was associated with higher odds of apathy and higher score of total NPI. Furthermore, for the effects of lacunae or WMH on total NPI score we set Clinical Dementia Rating Sum of Boxes as the mediator. Greater PiB retention ratio was associated with higher odds of delusions and irritability. The SVD and amyloid pathologies did not show interactive effects on NPS. Our findings suggested that SVD and amyloid burden independently affected specific NPS.
authors: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Hee Jin
authors: HJ
authors: Kim
authors: Sue J
authors: SJ
authors: Kang
authors: Changsoo
authors: C
authors: Kim
authors: Geon Ha
authors: GH
authors: Kim
authors: Seun
authors: S
authors: Jeon
authors: Jong Min
authors: JM
authors: Lee
authors: Seung Jun
authors: SJ
authors: Oh
authors: Jae Seung
authors: JS
authors: Kim
authors: Yearn Seong
authors: YS
authors: Choe
authors: Kyung Han
authors: KH
authors: Lee
authors: Young
authors: Y
authors: Noh
authors: Hanna
authors: H
authors: Cho
authors: Cindy W
authors: CW
authors: Yoon
authors: Juhee
authors: J
authors: Chin
authors: Jeffrey L
authors: JL
authors: Cummings
authors: Jae Hong
authors: JH
authors: Lee
authors: Duk L
authors: DL
authors: Na
authors: Sang Won
authors: SW
authors: Seo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D055806:Microvessels / Q000473:pathology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009483:Neuropsychological Tests; D058225:Plaque, Amyloid / Q000175:diagnosis* / Q000523:psychology*; D011446:Prospective Studies