title: Acquired and Heritable Thrombophilia in Indian Patients With Pediatric Deep Venous Thrombosis (DVT).
abstract: Deep venous thrombosis (DVT) in children is more often associated with underlying pathological conditions than with hereditary thrombophilia. The present study is a retrospective analysis of thrombophilia in 285 pediatric patients with venous thrombosis at different sites. Four common thrombophilia markers, that is protein C, protein S, antithrombin III, and factor V Leiden (FVL) mutation, were analyzed. Thrombosis in hepatic and portal veins was more common in pediatric patients (73%) when compared to other sites (27%). Overall, hereditary thrombophilia accounted for 15.5% of the patients with venous thrombosis. The FVL mutation, which was the major causative factor in Budd-Chiari syndrome and portal vein thrombosis cases in the adult group, was not a major contributing factor in pediatric group, that is, 1.8% of the patients. In conclusion, the risk factors for venous thrombosis vary in different age groups.
authors: National Institute of Immunohaematology (ICMR), KEM Hospital, Mumbai, India.
authors: Navin
authors: N
authors: Pai
authors: National Institute of Immunohaematology (ICMR), KEM Hospital, Mumbai, India.
authors: Kanjaksha
authors: K
authors: Ghosh
authors: National Institute of Immunohaematology (ICMR), KEM Hospital, Mumbai, India shrimatishetty@yahoo.com.
authors: Shrimati
authors: S
authors: Shetty
mesh_terms: D000293:Adolescent; D000990:Antithrombin III / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D006502:Budd-Chiari Syndrome / Q000097:blood / Q000209:etiology / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D009154:Mutation; D011486:Protein C / Q000378:metabolism*; D017293:Protein S / Q000378:metabolism*; D019851:Thrombophilia / Q000097:blood / Q000150:complications / Q000235:genetics
chemical_list: D015415:Biomarkers; D011486:Protein C; D017293:Protein S; C095381:factor V Leiden; D000990:Antithrombin III; D005165:Factor V
keywords: Budd–Chiari syndrome; deep venous thrombosis; infection; portal venous thrombosis; thrombophilia