title: One-year strabismus outcomes in the Infant Aphakia Treatment Study.
abstract: OBJECTIVE
  To evaluate the characteristics of strabismus in infants who underwent cataract surgery with and without intraocular lens (IOL) implantation.
  
  
  METHODS
  Secondary outcome analysis in a prospective, randomized clinical trial.
  
  
  METHODS
  The Infant Aphakia Treatment Study is a randomized, multicenter (n = 12), clinical trial comparing treatment of aphakia with a primary IOL or contact lens in 114 infants with a unilateral congenital cataract.
  
  
  METHODS
  Infants underwent cataract surgery with or without placement of an IOL.
  
  
  METHODS
  The proportion of patients in whom strabismus developed during the first 12 months of follow-up was calculated using the life-table method and was compared across treatment groups and age strata using a log-rank test.
  
  
  RESULTS
  Strabismus developed within the first 12 months of follow-up in 38 pseudophakic infants (life-table estimate, 66.7%) and 42 infants (life-table estimate, 74.5%) treated with contact lenses (P = 0.59). The younger cohort (<49 days) at the time of surgery demonstrated less strabismus (29 of 50; life-table estimate, 58.0%) than the older cohort (≥ 49 days; 51 of 64; life-table estimate, 80.0%; P<0.01).
  
  
  CONCLUSIONS
  Intraocular lens placement does not prevent the early development of strabismus after congenital cataract surgery. However, strabismus was less likely to develop in infants whose cataract was removed at an earlier age.
  
  
  BACKGROUND
  The author(s) have no proprietary or commercial interest in any materials discussed in this article.
authors: Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota 55455, USA. bothu003@umn.edu
authors: Erick D
authors: ED
authors: Bothun
authors: Julia
authors: J
authors: Cleveland
authors: Michael J
authors: MJ
authors: Lynn
authors: Stephen P
authors: SP
authors: Christiansen
authors: Deborah K
authors: DK
authors: Vanderveen
authors: Dan E
authors: DE
authors: Neely
authors: Stacey J
authors: SJ
authors: Kruger
authors: Scott R
authors: SR
authors: Lambert
mesh_terms: D001036:Aphakia, Postcataract / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D002386:Cataract / Q000151:congenital*; D002387:Cataract Extraction; D003261:Contact Lenses; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D015993:Life Tables; D008297:Male; D011446:Prospective Studies; D019591:Pseudophakia / Q000209:etiology / Q000503:physiopathology*; D012030:Refractive Errors / Q000503:physiopathology; D042262:Retinoscopy; D013285:Strabismus / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology