title: Impact of severe sepsis on serum and urinary biomarkers of acute kidney injury in critically ill children: an observational study.
abstract: OBJECTIVE
  We hypothesized that sepsis could have an impact on the sensitivity of serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC) for acute kidney injury (AKI) diagnosis in critically ill children.
  
  
  METHODS
  Serum NGAL (sNGAL) and urinary NGAL (uNGAL) and CysC were measured daily in the first 48 h from pediatric intensive care unit admission in 11 consecutive critically ill children with severe sepsis; a single measurement was made in a population of 10 healthy controls undergoing minor ambulatory surgery to exclude possible biases in the laboratory methods.
  
  
  RESULTS
  uNGAL, serum CysC (sCysC), and urinary CysC (uCysC) levels were significantly increased in patients with septic AKI compared with septic patients without AKI, while sNGAL levels were not significantly different between septic patients with and without AKI. Median serum creatinine levels did not show significant differences between AKI and non-AKI patients.
  
  
  CONCLUSIONS
  uNGAL, sCysC and uCysC were not altered by sepsis and were good predictors of AKI. In a septic state, sNGAL alone did not discriminate patients with AKI from those without AKI.
authors: Pediatric Anesthesia and Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. matteo.dinardo@tin.it
authors: Matteo
authors: M
authors: Di Nardo
authors: Alessio
authors: A
authors: Ficarella
authors: Zaccaria
authors: Z
authors: Ricci
authors: Rosa
authors: R
authors: Luciano
authors: Francesca
authors: F
authors: Stoppa
authors: Sergio
authors: S
authors: Picardo
authors: Stefano
authors: S
authors: Picca
authors: Maurizio
authors: M
authors: Muraca
authors: Paola
authors: P
authors: Cogo
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000652:urine; D000209:Acute-Phase Proteins / Q000652:urine*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D055316:Cystatin C / Q000097:blood* / Q000652:urine*; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D007677:Kidney Function Tests; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood* / Q000652:urine*; D008297:Male; D011518:Proto-Oncogene Proteins / Q000097:blood* / Q000652:urine*; D018805:Sepsis / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000652:urine
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D055316:Cystatin C; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins