title: The case for lower extremity allotransplantation.
abstract: BACKGROUND
  Despite generally excellent success with vascularized composite allotransplantation at many body sites over the past two decades, vascularized composite allotransplantation as a treatment modality for lower extremity amputees has not yet been fully embraced.
  
  
  METHODS
  The authors summarize the anticipated benefits of lower limb allotransplantation, and reference the likely controversies relevant to this restorative therapeutic modality.
  
  
  RESULTS
  Based on evidence culled from both upper extremity and lower extremity transplant experience to date, the authors posit that allotransplantation for lower limb amputees may be a reasonable pursuit.
  
  
  CONCLUSIONS
  The authors advocate for the renewed consideration of lower extremity allotransplantation.
authors: Boston, Mass.; Toronto, Ontario, Canada; and Valencia, Spain From the Division of Plastic Surgery, Brigham and Women's Hospital; the Division of Plastic Surgery, Sick Kids Hospital; and Clinica Cavadas.
authors: Matthew J
authors: MJ
authors: Carty
authors: Ronald
authors: R
authors: Zuker
authors: Pedro
authors: P
authors: Cavadas
authors: Julian J
authors: JJ
authors: Pribaz
authors: Simon G
authors: SG
authors: Talbot
authors: Bohdan
authors: B
authors: Pomahac
mesh_terms: D000674:Amputees / Q000534:rehabilitation; D001132:Arm / Q000637:transplantation; D006084:Graft Rejection / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007866:Leg / Q000098:blood supply / Q000294:innervation / Q000637:transplantation*; D008297:Male; D008866:Microsurgery / Q000379:methods; D009119:Muscle Contraction / Q000502:physiology; D016059:Range of Motion, Articular / Q000502:physiology; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents