title: Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity.
abstract: METHODS
  In this report, layered microporous titanate nanowire scaffolds (TiNWs) were constructed via a hydrothermal route and then decorated with anatase nanocrystals (ANs@TiNWs) by immersion in TiCl(4) solution. The diameter and specific surface area of the ANs@TiNWs was measured. The TiNWs and ANs@TiNWs were then compared for their ability to adsorb protein and adhere to MG63 cells.
  
  
  RESULTS
  The diameter and specific surface area of the ANs@TiNWs were significantly larger than for TiNWs, and the ANs@TiNWs had an enhanced protein-adsorbing effect. It was found that the MG63 cells were less able to adhere to the flat titanium substrate than the TiNWs and ANs@TiNWs, and that this cell-repellant ability was greater with ANs@TiNWs. Other MG63 cell functions, proliferation in particular, were also inhibited by ANs@TiNWs.
  
  
  CONCLUSIONS
  ANs@TiNWs show a high protein adsorption and cell-repellant capacity which would be useful in drug delivery.
authors: Center of Oral Implantology, Southern Medical University, Guangzhou, People's Republic of China.
authors: Xianglong
authors: X
authors: Ding
authors: Xiaoqin
authors: X
authors: Yang
authors: Lei
authors: L
authors: Zhou
authors: Haibin
authors: H
authors: Lu
authors: Shaobing
authors: S
authors: Li
authors: Yan
authors: Y
authors: Gao
authors: Chunhua
authors: C
authors: Lai
authors: Ying
authors: Y
authors: Jiang
mesh_terms: D000327:Adsorption; D000704:Analysis of Variance; D002448:Cell Adhesion / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D016503:Drug Delivery Systems; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D053770:Nanowires / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011506:Proteins / Q000378:metabolism; D013499:Surface Properties; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D011506:Proteins; C009495:titanium dioxide; D014025:Titanium
keywords: antiadhesion; drug delivery; nanotopography; protein adsorption