title: [Cytogenetic effects in peripheral blood lymphocytes in the offspring of Chernobyl nuclear power plant accident liquidators under the influence of mitomycin C in vitro and folic acid in vivo].
abstract: The data on cytogenetic examination concerning the offspring of the Chernobyl accident liquidators (cleanup personnel) have been obtained. It has been established that spontaneous chromosomal aberrations level before folic acid administration was 1,8 times higher than that value after its employment (4,45 to 2,42 %, p < 0,01). In lymphocyte cultures treated with mitomycin C accompanied by folic acid it was 4,5 times higher before their administration (23,95 to 5,36 %, p < 0,001). The data obtained confirm a possibility of stabilization of genetic apparatus in offspring of the Chernobyl disaster liquidators after folic acid administration.
authors: V I
authors: VI
authors: Kovaleva
authors: N V
authors: NV
authors: Bagatskaia
mesh_terms: D000293:Adolescent; D002478:Cells, Cultured; D047852:Chernobyl Nuclear Accident; D002648:Child; D002869:Chromosome Aberrations / Q000187:drug effects; D002908:Chronic Disease; D020732:Cytogenetic Analysis; D005260:Female; D005492:Folic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000235:genetics / Q000517:prevention & control; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000473:pathology*; D008297:Male; D008889:Military Personnel; D016685:Mitomycin / Q000494:pharmacology; D009440:Neurasthenia / Q000235:genetics / Q000517:prevention & control; D016273:Occupational Exposure; D018812:Paternal Exposure
chemical_list: D016685:Mitomycin; D005492:Folic Acid