title: Ertapenem use and antimicrobial resistance to group 2 carbapenems in Gram-negative infections: a systematic review.
abstract: The authors sought to evaluate the impact of ertapenem use on the resistance of Gram-negative bacteria (in general and in specific species) to group 2 carbapenems. PubMed and Scopus databases were systematically searched. Eight studies were included; all reported on Pseudomonas aeruginosa and four reported on Enterobacteriaceae. Five studies did not show any difference in group 2 carbapenem resistance for P. aeruginosa, while three reported a significant decline after ertapenem introduction. Three studies did not show any difference in group 2 carbapenem resistance between the compared periods for Enterobacteriaceae and one study did not present a statistical analysis. In conclusion, the currently available data suggest that ertapenem use does not affect the resistance of Gram-negative bacteria to group 2 carbapenems.
authors: Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece. m.falagas@aibs.gr
authors: Matthew E
authors: ME
authors: Falagas
authors: Giannoula S
authors: GS
authors: Tansarli
authors: Anastasios
authors: A
authors: Kapaskelis
authors: Konstantinos Z
authors: KZ
authors: Vardakas
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015780:Carbapenems / Q000494:pharmacology / Q000627:therapeutic use; D000077727:Ertapenem; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000502:physiology; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology; D018440:beta-Lactam Resistance / Q000187:drug effects* / Q000502:physiology; D047090:beta-Lactams / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D047090:beta-Lactams; D000077727:Ertapenem