title: IK induced by coxsackievirus B3 infection transiently downregulates expression of MHC class II through increasing cAMP.
abstract: Major histocompatibility complex (MHC) class II expression is critical for the presentation of antigens in the immune response to viral infection. Consequently, some viruses regulate the MHC class II-mediated presentation of viral antigens as a mechanism of immune escape. In this study, we found that Coxsackievirus B3 (CVB3) infection transiently increased IK expression, which reduced the expression of MHC class II (I-A/I-E) on splenic B cells. Interestingly, CVB3-induced IK elevated cAMP, a downstream molecule of the G protein-coupled receptors, which inhibited MHC class II presentation on B cells. Transgenic mice expressing truncated IK showed lower expression of MHC class II on B cells than did wild-type mice after CVB3 infection. Taken together, these results imply that IK plays a role in downregulating MHC class II expression on B cells during CVB3 infection through the induction of cAMP.
authors: Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.
authors: Hye-Lim
authors: HL
authors: Park
authors: Yeon-Jung
authors: YJ
authors: Kim
authors: Ha-Na
authors: HN
authors: Na
authors: Mi-Young
authors: MY
authors: Park
authors: Joo-Young
authors: JY
authors: Kim
authors: Cheol-Won
authors: CW
authors: Yun
authors: Jae-Hwan
authors: JH
authors: Nam
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003384:Coxsackievirus Infections / Q000276:immunology; D000242:Cyclic AMP / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology; D004195:Disease Models, Animal; D015536:Down-Regulation; D029822:Enterovirus B, Human / Q000276:immunology* / Q000472:pathogenicity; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis* / Q000276:immunology; D057131:Immune Evasion; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic
chemical_list: D016207:Cytokines; D000949:Histocompatibility Antigens Class II; C484250:Ik protein, mouse; D000242:Cyclic AMP