title: A case-control association study between Obsessive-Compulsive Disorder (OCD) and the MCP-1 -2518G/A polymorphism in a Chinese sample.
abstract: OBJECTIVE
  To investigate the association between Obsessive-Compulsive Disorder (OCD) and a functional polymorphism of MCP-1 in the Chinese Han population.
  
  
  METHODS
  We genotyped and performed a case-control association analysis of the MCP-1 -2518G/A polymorphism in 200 OCD patients and 294 healthy control subjects.
  
  
  RESULTS
  There was no significant difference in MCP-1 -2518G/A genotypic and allelic frequencies between OCD cases and controls (x² = 1.123, df = 2, P = 0.57 by genotype; x² = 0.802, df = 1, P = 0.37 by allele).
  
  
  CONCLUSIONS
  Our results indicated that MCP-1 -2518G/A may not play a major role in the genetic predisposition of the Chinese Han population to OCD. However, further studies using a larger number of subjects are required to obtain a clear conclusion.
authors: Department of Pychology and Psychiatry, Medical College, Qingdao University, Qingdao, China.
authors: Xinhua
authors: X
authors: Zhang
authors: Yingying
authors: Y
authors: Yin
authors: Shiguo
authors: S
authors: Liu
authors: Xu
authors: X
authors: Ma
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods*; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2