title: In vitro fertilization outcome in women with unoperated bilateral endometriomas.
abstract: OBJECTIVE
  To evaluate IVF outcome in women with unoperated bilateral endometriomas.
  
  
  METHODS
  Multicenter retrospective cohort study.
  
  
  METHODS
  Two infertility units.
  
  
  METHODS
  Thirty-nine women with bilateral endometriomas matched with 78 unexposed control subjects.
  
  
  METHODS
  Analysis of data from patients who underwent in vitro fertilization (IVF)-intracytoplasmic sperm injection.
  
  
  METHODS
  Ovarian responsiveness and oocyte quality.
  
  
  RESULTS
  Responsiveness to ovarian hyperstimulation was significantly reduced in women with bilateral endometriomas. The total numbers of developing follicles in case and control subjects were 9.6 ± 3.3 and 14.1 ± 6.8, respectively. The numbers of oocytes retrieved were 7.1 ± 3.2 and 9.8 ± 5.5, respectively. Conversely, oocyte retrieval was not hampered by the presence of the ovarian endometriomas. The rates (interquartile range) of oocytes retrieved per total number of developing follicles in case and control subjects were 77% (57%-88%) and 71% (63%-79%), respectively. Moreover, the quality of the retrieved oocytes did not differ. The fertilization rates (IQR) were 67% (56%-100%) and 70% (57%-100%), respectively. The rates (IQR) of top quality embryos per oocyte used were 33% (25%-50%) and 33% (20%-43%), respectively. The implantation rates were 22% and 23%, respectively. The clinical pregnancy rate and the delivery rate also did not differ.
  
  
  CONCLUSIONS
  Although the presence of bilateral endometriomas at the time of IVF affects responsiveness to hyperstimulation, the quality of the oocytes retrieved and the chances of pregnancy are not affected.
authors: Department of Obstetrics and Gynecology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. laurabenaglia@hotmail.it
authors: Laura
authors: L
authors: Benaglia
authors: Alfonso
authors: A
authors: Bermejo
authors: Edgardo
authors: E
authors: Somigliana
authors: Sonia
authors: S
authors: Faulisi
authors: Guido
authors: G
authors: Ragni
authors: Luigi
authors: L
authors: Fedele
authors: Juan A
authors: JA
authors: Garcia-Velasco
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004715:Endometriosis / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000639:trends*; D006801:Humans; D054315:Oocyte Retrieval / Q000379:methods / Q000639:trends; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends*; D012189:Retrospective Studies