title: Nanovaccines : nanocarriers for antigen delivery.
abstract: Vaccination has become one of the most important health interventions of our times, revolutionizing health care, and improving the quality of life and life expectancy of millions all over the world. In spite of this, vaccine research remains a vast field for innovation and improvement. Indeed, the shift towards the use of sub-unit antigens, much safer but less immunogenic, and the recognized need to facilitate the access to vaccines in the global framework is currently stimulating the search for safe and efficient adjuvants and delivery technologies. Within this context, nanocarriers have gained particular attention over the last years and appear as one of the most promising strategies for antigen delivery. A number of biomaterials and technologies can be used to design nanovaccines that fulfill the requirements of new vaccination approaches, such as single-dose and transmucosal immunization, critical for achieving a widespread coverage while reducing the overall costs in relation to traditional forms of vaccination. Here we present an overview of the current state of nanocarriers for antigen delivery, developed with the perspective of contributing to the global vaccination goal.
authors: NanoBioFar Group, Center for Research in Molecular Medicine and Chronic Diseases, Campus Vida, University of Santiago de Compostela USC, Avenida 15782 Barcelona s/n, Santiago de Compostela, Spain.
authors: Jose Vicente
authors: JV
authors: Gonzalez-Aramundiz
authors: Ana Sara
authors: AS
authors: Cordeiro
authors: Nœmi
authors: N
authors: Csaba
authors: Maria
authors: M
authors: de la Fuente
authors: María José
authors: MJ
authors: Alonso
mesh_terms: D000276:Adjuvants, Immunologic; D000281:Administration, Intranasal; D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006801:Humans; D009092:Mucous Membrane; D053769:Nanocapsules; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods / Q000639:trends; D014611:Vaccination / Q000379:methods / Q000639:trends; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D000276:Adjuvants, Immunologic; D000941:Antigens; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D053769:Nanocapsules; D014612:Vaccines