title: Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort.
abstract: BACKGROUND
  Bisphenol A (BPA), a widely used endocrine-disrupting chemical, has been associated with increased body weight and fat deposition in rodents.
  
  
  OBJECTIVE
  We examined whether prenatal and postnatal urinary BPA concentrations were associated with body mass index (BMI), waist circumference, percent body fat, and obesity in 9-year-old children (n = 311) in the CHAMACOS longitudinal cohort study.
  
  
  METHODS
  BPA was measured in spot urine samples collected from mothers twice during pregnancy and from children at 5 and 9 years of age.
  
  
  RESULTS
  Prenatal urinary BPA concentrations were associated with decreased BMI at 9 years of age in girls but not boys. Among girls, being in the highest tertile of prenatal BPA concentrations was associated with decreased BMI z-score (β = -0.47, 95% CI: -0.87, -0.07) and percent body fat (β = -4.36, 95% CI: -8.37, -0.34) and decreased odds of overweight/obesity [odds ratio (OR) = 0.37, 95% CI: 0.16, 0.91] compared with girls in the lowest tertile. These findings were strongest in prepubertal girls. Urinary BPA concentrations at 5 years of age were not associated with any anthropometric parameters at 5 or 9 years, but BPA concentrations at 9 years were positively associated with BMI, waist circumference, fat mass, and overweight/obesity at 9 years in boys and girls.
  
  
  CONCLUSIONS
  Consistent with other cross-sectional studies, higher urinary BPA concentrations at 9 years of age were associated with increased adiposity at 9 years. However, increasing BPA concentrations in mothers during pregnancy were associated with decreased BMI, body fat, and overweight/obesity among their daughters at 9 years of age.
authors: Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, Berkeley, California 94704, USA. kharley@berkeley.edu
authors: Kim G
authors: KG
authors: Harley
authors: Raul
authors: R
authors: Aguilar Schall
authors: Jonathan
authors: J
authors: Chevrier
authors: Kristin
authors: K
authors: Tyler
authors: Helen
authors: H
authors: Aguirre
authors: Asa
authors: A
authors: Bradman
authors: Nina T
authors: NT
authors: Holland
authors: Robert H
authors: RH
authors: Lustig
authors: Antonia M
authors: AM
authors: Calafat
authors: Brenda
authors: B
authors: Eskenazi
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity; D000328:Adult; D001559:Benzhydryl Compounds / Q000633:toxicity / Q000652:urine*; D015992:Body Mass Index; D002140:California; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D052244:Endocrine Disruptors / Q000633:toxicity / Q000652:urine*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000139:chemically induced / Q000453:epidemiology*; D050177:Overweight / Q000453:epidemiology / Q000209:etiology; D010636:Phenols / Q000633:toxicity / Q000652:urine*; D011247:Pregnancy; D053719:Tandem Mass Spectrometry; D055105:Waist Circumference; D055815:Young Adult; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds