title: Microwave assisted nano (ZnO-TiO2) catalyzed synthesis of some new 4,5,6,7-tetrahydro-6-((5-substituted-1,3,4-oxadiazol-2-yl)methyl)thieno[2,3-c]pyridine as antimicrobial agents.
abstract: Combined nano zinc oxide and titanium dioxide [nano (ZnO-TiO(2))] has been reported first time for the synthesis of novel series of 4,5,6,7-tetrahydro-6-((5-substituted-1,3,4-oxadiazol-2-yl)methyl)thieno[2,3-c]pyridine. All the synthesized compounds (7a-7m) are novel and were screened for their antimicrobial activity against four different strains like Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis and antifungal activity was determined against two strains Candida albicans and Aspergillus niger. SAR for the newly synthesised derivatives has been developed by comparing their MIC values with ampicillin, ciprofloxacin and miconazole for antibacterial and antifungal activities, respectively. Among the synthesized compounds, 2,6 dichlorophenyl analogue (7f), 4 fluorophenyl analogue (7k) and 2,6 dichlorophenyl analogue (7l) shows promising antibacterial as well as antifungal activity whereas thiophene substituted compound (7j) shows promising antibacterial activity.
authors: Dr. Rafiq Zakaria Campus, Y.B. Chavan College of Pharmacy, Aurangabad 431 001 (M.S.), India. jnsangshetti@rediffmail.com
authors: Jaiprakash N
authors: JN
authors: Sangshetti
authors: Priyanka P
authors: PP
authors: Dharmadhikari
authors: Rashmi S
authors: RS
authors: Chouthe
authors: Bibi
authors: B
authors: Fatema
authors: Vishal
authors: V
authors: Lad
authors: Vikram
authors: V
authors: Karande
authors: Sunil N
authors: SN
authors: Darandale
authors: Devanand B
authors: DB
authors: Shinde
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002384:Catalysis; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014025:Titanium / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: C583674:4,5,6,7-tetrahydro-6-((1,3,4-oxadiazol-2-yl)methyl)thieno(2,3-c)pyridine; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010069:Oxadiazoles; D011725:Pyridines; C009495:titanium dioxide; D014025:Titanium; D015034:Zinc Oxide