title: AT2 Receptor-Interacting Proteins ATIPs in the Brain.
abstract: A complete renin-angiotensin system (RAS) is locally expressed in the brain and fulfills important functions. Angiotensin II, the major biologically active peptide of the RAS, acts via binding to two main receptor subtypes designated AT1 and AT2. The present paper focuses on AT2 receptors, which have been reported to have neuroprotective effects on stroke, degenerative diseases, and cognitive functions. Our group has identified a family of AT2 receptor interacting proteins (ATIPs) comprising three major members (ATIP1, ATIP3, and ATIP4) with different intracellular localization. Of interest, all ATIP members are expressed in brain tissues and carry a conserved domain able to interact with the AT2 receptor intracellular tail, suggesting a role in AT2-mediated brain functions. We summarize here current knowledge on the ATIP family of proteins, and we present new experimental evidence showing interaction defects between ATIP1 and two mutant forms of the AT2 receptor identified in cases of mental retardation. These studies point to a functional role of the AT2/ATIP1 axis in cognition.
authors: Inserm U1016, Paris 75014, France ; CNRS UMR 8104, Paris 75014, France ; Institut Cochin, Université Paris Descartes, 22 Rue Méchain, 75014 Paris, France.
authors: Sylvie
authors: S
authors: Rodrigues-Ferreira
authors: Erwann
authors: E
authors: le Rouzic
authors: Traci
authors: T
authors: Pawlowski
authors: Anand
authors: A
authors: Srivastava
authors: Florence
authors: F
authors: Margottin-Goguet
authors: Clara
authors: C
authors: Nahmias