title: In vivo imaging of the rodent eye with swept source/Fourier domain OCT.
abstract: Swept source/Fourier domain OCT is demonstrated for in vivo imaging of the rodent eye. Using commercial swept laser technology, we developed a prototype OCT imaging system for small animal ocular imaging operating in the 1050 nm wavelength range at an axial scan rate of 100 kHz with ~6 µm axial resolution. The high imaging speed enables volumetric imaging with high axial scan densities, measuring high flow velocities in vessels, and repeated volumetric imaging over time. The 1050 nm wavelength light provides increased penetration into tissue compared to standard commercial OCT systems at 850 nm. The long imaging range enables multiple operating modes for imaging the retina, posterior eye, as well as anterior eye and full eye length. A registration algorithm using orthogonally scanned OCT volumetric data sets which can correct motion on a per A-scan basis is applied to compensate motion and merge motion corrected volumetric data for enhanced OCT image quality. Ultrahigh speed swept source OCT is a promising technique for imaging the rodent eye, proving comprehensive information on the cornea, anterior segment, lens, vitreous, posterior segment, retina and choroid.
authors: Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA,  USA.
authors: Jonathan J
authors: JJ
authors: Liu
authors: Ireneusz
authors: I
authors: Grulkowski
authors: Martin F
authors: MF
authors: Kraus
authors: Benjamin
authors: B
authors: Potsaid
authors: Chen D
authors: CD
authors: Lu
authors: Bernhard
authors: B
authors: Baumann
authors: Jay S
authors: JS
authors: Duker
authors: Joachim
authors: J
authors: Hornegger
authors: James G
authors: JG
authors: Fujimoto
keywords: (170.3880) Medical and biological imaging; (170.4470) Ophthalmology; (170.4500) Optical coherence tomography