title: Hierarchical polymer brush nanoarrays: a versatile way to prepare multiscale patterns of proteins.
abstract: This paper presents a versatile way to prepare multiscale and gradient patterns of proteins. The protein patterns are fabricated by conjugating proteins covalently on patterns of polymer brush that are prepared by techniques combining colloidal lithography with photolithography, and two-step colloidal lithography. Taking advantages of this technique, the parameters of protein patterns, such as height, diameters, periods, and distances between two dots, can be arbitrarily tuned. In addition, the protein patterns with varies of architectures, such as microdiscs, microstripes, microrings, microtriangles, microgrids, etc., consisting of protein nanodots, are prepared and the sample size is up to 4 cm(2). The as-prepared patterns of fibronectin can promote the cell adhesion and cell location.
authors: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
authors: Yunfeng
authors: Y
authors: Li
authors: Junhu
authors: J
authors: Zhang
authors: Wendong
authors: W
authors: Liu
authors: Daowei
authors: D
authors: Li
authors: Liping
authors: L
authors: Fang
authors: Hongchen
authors: H
authors: Sun
authors: Bai
authors: B
authors: Yang
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002460:Cell Line; D005353:Fibronectins / Q000737:chemistry; D051379:Mice; D018625:Microscopy, Atomic Force; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D005353:Fibronectins; D011108:Polymers; D011506:Proteins; D011102:Polyhydroxyethyl Methacrylate