title: Management of colorectal cancer in patients with inflammatory bowel disease.
abstract: BACKGROUND
  This study evaluated the clinicopathological features and survival rates of patients with inflammatory bowel disease who developed colorectal cancer (CRC).
  
  
  METHODS
  A retrospective review was performed on a prospectively maintained institutional database (1981-2011) to identify patients with inflammatory bowel disease who developed CRC. Clinicopathological parameters, management and outcomes were analysed.
  
  
  RESULTS
  A total of 2,843 patients with inflammatory bowel disease were identified. One thousand six hundred and forty-two had ulcerative colitis (UC) and 1,201 had Crohn's disease (CD). Following exclusion criteria, there were 29 patients with biopsy-proven colorectal carcinoma, 22 of whom had UC and 7 had CD. Twenty-six patients had a preoperative diagnosis of malignancy/dysplasia; 16 of these were diagnosed at surveillance endoscopy. Nodal/distant metastasis was identified at presentation in 47 and 71 % of the UC and CD group, respectively. Operative morbidity for UC and CD was 33 and 17 %, respectively. Despite the less favourable operative outcomes following surgery management of UC-related CRC, overall 5-year survival was significantly better in the UC group compared to the CD group (41 vs. 29 %; p = 0.04) reflecting the difference in stage at presentation between the two groups.
  
  
  CONCLUSIONS
  Patients who undergo surgery for UC-related CRC have less favourable short-term outcomes but present at a less advanced stage and have a more favourable long-term prognosis than similar patients with CRC and CD.
authors: Center for Colorectal Disease, St. Vincent's University Hospital, Dublin, Ireland, dara_kav@hotmail.com.
authors: D O
authors: DO
authors: Kavanagh
authors: M C
authors: MC
authors: Carter
authors: D
authors: D
authors: Keegan
authors: G
authors: G
authors: Doherty
authors: M J
authors: MJ
authors: Smith
authors: J M P
authors: JM
authors: Hyland
authors: H
authors: H
authors: Mulcahy
authors: K
authors: K
authors: Sheahan
authors: P R
authors: PR
authors: O' Connell
authors: D P
authors: DP
authors: O' Donoghue
authors: D C
authors: DC
authors: Winter
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003093:Colitis, Ulcerative / Q000150:complications*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome