title: Non-surgical periodontal therapy decreases serum elastase levels in aggressive but not in chronic periodontitis.
abstract: OBJECTIVE
  Assessment of the effect of non-surgical periodontal therapy (SRP) on serum inflammatory parameters in patients with untreated aggressive (AgP) and chronic (ChP) periodontitis.
  
  
  METHODS
  Overall, 31 ChP and 29 AgP were examined clinically prior to and 12 weeks after SRP (subgingival scaling of all pockets within 2 days) with systemic antibiotics for patients positive for Aggregatibacter actinomycetemcomitans (14 AgP, 9 ChP). Blood was sampled prior to, one day, 6, and 12 weeks after the first SRP visit. Serum elastase, C-reactive protein (CRP), lipopolysaccharide-binding protein (LBP), interleukin (IL) 6, 8, and leukocyte counts were assessed.
  
  
  RESULTS
  At baseline, serum elastase, CRP, and LBP were significantly (p < 0.01) higher in AgP than ChP. Serum elastase, CRP, LBP, and IL-6 were significantly (p < 0.001) elevated one day after scaling in both groups. Both groups showed significant clinical improvement (p < 0.001). A significant difference was observed regarding change of serum elastase 12 weeks after SRP between AgP and ChP (p = 0.015). Multiple regression analysis revealed AgP, African origin, and bleeding on probing to be associated with more pronounced elastase reduction. CRP reduction was associated with African origin, systemic antibiotics, and baseline probing pocket depth.
  
  
  CONCLUSIONS
  SRP results in serum elastase reduction in AgP but not in ChP.
authors: Department of Periodontology, Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt/Main, Frankfurt, Germany. eickholz@med.uni-frankfurt.de
authors: Peter
authors: P
authors: Eickholz
authors: Yasemin
authors: Y
authors: Siegelin
authors: Susanne
authors: S
authors: Scharf
authors: Beate
authors: B
authors: Schacher
authors: Gerhard M
authors: GM
authors: Oremek
authors: Hildegund
authors: H
authors: Sauer-Eppel
authors: Ralf
authors: R
authors: Schubert
authors: Martin
authors: M
authors: Wohlfeil
mesh_terms: D000209:Acute-Phase Proteins; D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood / Q000201:enzymology* / Q000628:therapy*; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D044466:Asian People; D044383:Black People; D002097:C-Reactive Protein / Q000032:analysis; D002352:Carrier Proteins / Q000097:blood; D055113:Chronic Periodontitis / Q000097:blood / Q000201:enzymology* / Q000628:therapy*; D012534:Dental Scaling; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007958:Leukocyte Count; D019272:Leukocyte Elastase / Q000097:blood*; D016014:Linear Models; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D010512:Periodontal Index; D018709:Statistics, Nonparametric; D044465:White People; D055815:Young Adult; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein; D002352:Carrier Proteins; D015850:Interleukin-6; D016209:Interleukin-8; D019272:Leukocyte Elastase; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein