title: Study on the clinical significance of Argonaute2 expression in colonic carcinoma by tissue microarray.
abstract: BACKGROUND
  To study the expression levels and clinical significance of Argonaute2 (EIF2C2) on colonic carcinomas and normal tissues.
  
  
  METHODS
  Colon tissue samples from 90 cases of colonic carcinomas and 90 normal subjects were accumulated and made into a tissue microarray containing 360 dots. Expression of Argonaute2 (EIF2C2) was detected by immunohistochemical staining of the tissue microarray.
  
  
  RESULTS
  There was significant difference in the expression levels of Argonaute2 (EIF2C2) between colonic carcinomas and normal tissues (P<0.01). However, the expression of Argonaute2 (EIF2C2) was not related to sex, age, position, differentiation, lymphatic metastasis and clinical stage of the tumor (P>0.05).
  
  
  CONCLUSIONS
  Abnormal expression of Argonaute2 (EIF2C2) may be correlated with colon tumorigenesis.
authors: Department of Gastroenterology, Tongji University Shanghai, China.
authors: Ying-Xin
authors: YX
authors: Wang
authors: Xiao-Yan
authors: XY
authors: Zhang
authors: Bao-Feng
authors: BF
authors: Zhang
authors: Chang-Qing
authors: CQ
authors: Yang
authors: Heng-Jun
authors: HJ
authors: Gao
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060565:Argonaute Proteins / Q000378:metabolism*; D003106:Colon / Q000378:metabolism / Q000473:pathology*; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D046888:Tissue Array Analysis / Q000379:methods*
chemical_list: C466422:AGO2 protein, human; D060565:Argonaute Proteins
keywords: Argonaute2; Tissue mircroarray; colonic carcinoma; immunohistochemstry