title: Oocyte in vitro maturation in normo-ovulatory women.
abstract: OBJECTIVE
  To review the scientific literature concerning the application of oocyte in vitro maturation (IVM) as a treatment for normo-ovulatory women.
  
  
  METHODS
  Critical evaluation and comparison of the most relevant clinical studies.
  
  
  METHODS
  Public IVF unit.
  
  
  METHODS
  Normo-ovulatory women.
  
  
  METHODS
  Oocyte IVM and cryopreservation.
  
  
  METHODS
  Maturation, fertilization, implantation, and pregnancy rates.
  
  
  RESULTS
  Maturation rates in vitro are suboptimal and influenced by several factors. IVM oocytes fertilize and undergo development in vitro with rates similar to in vivo matured control oocytes. In IVM cycles implantation and pregnancy rates are lower compared with controlled ovarian stimulation treatments, but accurate patient selection can improve IVM clinical outcome.
  
  
  CONCLUSIONS
  In normal responders, IVM does not reach success rates similar to conventional ovarian stimulation regimens. However, it represents a milder approach to assisted reproduction treatment and an alternative intervention for specific conditions.
authors: Biogenesi Reproductive Medicine Center, Istituti Clinici Zucchi, Monza, Italy.
authors: Rubens
authors: R
authors: Fadini
authors: Mario
authors: M
authors: Mignini Renzini
authors: Mariabeatrice
authors: M
authors: Dal Canto
authors: Amalia
authors: A
authors: Epis
authors: Marilena
authors: M
authors: Crippa
authors: Ilaria
authors: I
authors: Caliari
authors: Claudio
authors: C
authors: Brigante
authors: Giovanni
authors: G
authors: Coticchio
mesh_terms: D010064:Embryo Implantation; D005260:Female; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques / Q000379:methods*; D009865:Oocytes / Q000166:cytology*; D010060:Ovulation / Q000502:physiology*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate