title: [Primary cilia of cells of cardiovascular apparatus].
abstract: The primary cilium is a mechanosensory, solitary, non-motile microtubule-based structure that in the quiescent phase of the cell cycle projects from the surface of the majority of human cells, including embryonal, stem and mesenchymal cells, fibroblasts, myoblasts, cardiomyocytes, vascular smooth muscle and endothelial cells. Primary cilia are in increased frequency also present on the surface of endothelial cells in atherosclerotic predilection sites, lipoid streaks and dots and atheromatous plaques. The primary cilium is formed from the mother centriole. Primary cilia are currently studied in mechanobiology of cardiovascular apparatus and their role in cell migration, cell cycle control and atherogenesis. The aim of this paper is to provide a review of the current knowledge on the primary cilia of cells of cardiovascular apparatus.
authors: Klinika onkologie a radioterapie Lekarske fakulty UK a FN Hradec Kralove. dvorakj@fnhk.cz
authors: J
authors: J
authors: Dvořák
authors: V
authors: V
authors: Sitorová
authors: D H
authors: DH
authors: Nikolov
authors: J
authors: J
authors: Mokrý
authors: I
authors: I
authors: Richter
authors: S
authors: S
authors: Filip
authors: A
authors: A
authors: Ryška
authors: J
authors: J
authors: Petera
mesh_terms: D002923:Cilia / Q000502:physiology* / Q000648:ultrastructure; D042783:Endothelial Cells / Q000502:physiology / Q000648:ultrastructure*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000502:physiology / Q000648:ultrastructure*; D032383:Myocytes, Cardiac / Q000502:physiology / Q000648:ultrastructure*