title: Hemodynamic effects of 6% hydroxyethyl starch infusion in sevoflurane-anesthetized thoroughbred horses.
abstract: To determine hemodynamic effects of hydroxyethyl starch (HES) infusion during anesthesia in horses, incremental doses of 6% HES were administered to 6 healthy Thoroughbred horses. Anesthesia was induced with xylazine, guaifenesin and thiopental and maintained with sevoflurane at 2.8% of end-tidal concentration in all horses. The horses were positioned in right lateral recumbency and administered 3 intravenous dose of 6% HES (5 ml/kg) over 15 min with 15-min intervals in addition to constant infusion of lactated Ringer's solution at 10 ml/kg/hr. Hemodynamic parameters were measured before and every 15 min until 90 min after the administration of 6% HES. There was no significant change in heart rate and arterial blood pressures throughout the experiment. The HES administration produced significant increases in mean right atrial pressure, stroke volume, cardiac output (CO) and decrease in systemic vascular resistance (SVR) in a dose-dependent manner. There was no significant change in electrolytes (Na(+), K(+), Cl(-)) throughout the experiment, however, packed cell volume, hemoglobin concentration, and total protein and albumin concentrations decreased in a dose-dependent manner following the HES administration. In conclusion, the HES administration provides a dose-dependent increase in CO, but has no impact upon arterial blood pressures due to a simultaneous decrease in SVR.
authors: Racehorse Clinic, Ritto Training Center, Japan Racing Association (JRA), 1028 Misono, Ritto-shi, Shiga 520-3085, Japan. Minoru_Ota@jra.go.jp
authors: Minoru
authors: M
authors: Ohta
authors: Shinjiro
authors: S
authors: Kurimoto
authors: Hirotaka
authors: H
authors: Tokushige
authors: Taisuke
authors: T
authors: Kuroda
authors: Yuhiro
authors: Y
authors: Ishikawa
mesh_terms: D061605:Administration, Intravenous / Q000662:veterinary; D000758:Anesthesia / Q000379:methods / Q000662:veterinary*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000097:blood; D005260:Female; D006140:Guaifenesin; D006439:Hemodynamics / Q000187:drug effects*; D006736:Horses; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D013874:Thiopental; D014991:Xylazine
chemical_list: D004573:Electrolytes; D006895:Hydroxyethyl Starch Derivatives; D014991:Xylazine; D006140:Guaifenesin; D013874:Thiopental