title: Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples.
abstract: TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.
authors: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, USA. rong.jiang@duke.edu
authors: Rong
authors: R
authors: Jiang
authors: Beverly H
authors: BH
authors: Brummett
authors: Elizabeth R
authors: ER
authors: Hauser
authors: Michael A
authors: MA
authors: Babyak
authors: Ilene C
authors: IC
authors: Siegler
authors: Abanish
authors: A
authors: Singh
authors: Arne
authors: A
authors: Astrup
authors: Oluf
authors: O
authors: Pedersen
authors: Torben
authors: T
authors: Hansen
authors: Claus
authors: C
authors: Holst
authors: Thorkild I A
authors: TI
authors: Sørensen
authors: Redford B
authors: RB
authors: Williams
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D017028:Caregivers / Q000523:psychology; D003718:Denmark; D058068:Endophenotypes; D005190:Family / Q000523:psychology*; D005260:Female; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics*; D008875:Middle Aged; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D020641:Polymorphism, Single Nucleotide; D013315:Stress, Psychological / Q000097:blood* / Q000235:genetics* / Q000523:psychology; D014280:Triglycerides / Q000097:blood*; D014481:United States; D044465:White People
chemical_list: D026901:Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; C400783:TOMM40 protein, human; D014280:Triglycerides