title: Paraoxonase 1 and arylesterase levels in children with familial Mediterranean fever.
abstract: BACKGROUND
  The pathogenesis of Familial Mediterranean Fever (FMF) is not clearly elucidated. It emerges as a result of triggering of the several environmental factors at the people who are genetically vulnerable.
  
  
  OBJECTIVE
  To evaluate the anti-oxidant enzymes at the remission period of familial mediterranean fever (FMF).
  
  
  METHODS
  Study group is consisted of 80 patients between the age of 2 and 16 years old who are routinely followed up. The control group is consisted of 80 healthy children whose physical examination is normal, and whose demographic findings are similar to the study group. Paraoxonase 1 (PON1) and arylesterase (ARE) levels are measured at both study and control group.
  
  
  RESULTS
  The difference between the levels of ARE and PON1 are statistically significant between the FMF and control group (p = 0.007, p = 0.001). According to the weight scoring, ARE and PON1 levels of light cases are higher versus the levels of moderate cases (p < 0.01).
  
  
  CONCLUSIONS
  Endogenous anti-oxidants Paraoxonase 1 and arylesterase levels are important in evaluating the inflammation at the remission period of FMF.
authors: Ataturk University, Faculty of Medicine, Department of Pediatric Nephrology, Erzurum, Turkey.
authors: C
authors: C
authors: Kosan
authors: A
authors: A
authors: Cayir
authors: M I
authors: MI
authors: Turan
authors: S
authors: S
authors: Ustebay
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D010505:Familial Mediterranean Fever / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D012720:Severity of Illness Index
chemical_list: D000975:Antioxidants; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human