title: Choroidal thickness outside the laser irradiation area after photodynamic therapy in polypoidal choroidal vasculopathy.
abstract: OBJECTIVE
  To evaluate changes in choroidal thickness adjacent to the area of laser application after photodynamic therapy (PDT) in patients with polypoidal choroidal vasculopathy (PCV) using enhanced depth imaging spectral-domain optical coherence tomography.
  
  
  METHODS
  Masked observers measured the choroidal thickness at the subfovea and superior, inferior and temporal areas adjacent to the area of laser application before, 2 days, 1 week and 1 and 3 months after treatment.
  
  
  RESULTS
  Thirty-seven patients with PCV treated with PDT with verteporfin were included. The mean subfoveal choroidal thickness decreased significantly (P < 0.001) from 256 ± 115 μm at baseline to 207 ± 111 μm at 3 months; the mean outside choroidal thickness including the superior, inferior and temporal areas decreased significantly (P < 0.001) from 240 ± 92 μm at baseline to 209 ± 86 μm at 3 months.
  
  
  CONCLUSIONS
  PDT affected not only the subfoveal choroid, but also the choroid outside the area of laser application in PCV.
authors: Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors: Yukinori
authors: Y
authors: Sugano
authors: Tomohiro
authors: T
authors: Iida
authors: Ichiro
authors: I
authors: Maruko
authors: Akira
authors: A
authors: Ojima
authors: Tetsuju
authors: T
authors: Sekiryu
mesh_terms: D000368:Aged; D002829:Choroid / Q000098:blood supply / Q000473:pathology*; D015862:Choroid Diseases / Q000473:pathology / Q000628:therapy*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011166:Porphyrins / Q000627:therapeutic use*; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D000077362:Verteporfin; D014792:Visual Acuity
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin