title: Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus.
abstract: Bacterial interference creates an ecological competition between commensal and pathogenic bacteria. Through fermentation of milk with gut-friendly bacteria, yogurt is an excellent aid to balance the bacteriological ecosystem in the human intestine. Here, we demonstrate that fermentation of glycerol with Propionibacterium acnes (P. acnes), a skin commensal bacterium, can function as a skin probiotic for in vitro and in vivo growth suppression of USA300, the most prevalent community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). We also promote the notion that inappropriate use of antibiotics may eliminate the skin commensals, making it more difficult to fight pathogen infection. This study warrants further investigation to better understand the role of fermentation of skin commensals in infectious disease and the importance of the human skin microbiome in skin health.
authors: Division of Dermatology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
authors: Muya
authors: M
authors: Shu
authors: Yanhan
authors: Y
authors: Wang
authors: Jinghua
authors: J
authors: Yu
authors: Sherwin
authors: S
authors: Kuo
authors: Alvin
authors: A
authors: Coda
authors: Yong
authors: Y
authors: Jiang
authors: Richard L
authors: RL
authors: Gallo
authors: Chun-Ming
authors: CM
authors: Huang
mesh_terms: D000818:Animals; D005285:Fermentation; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D064307:Microbiota; D019936:Probiotics / Q000378:metabolism*; D011425:Propionibacterium acnes / Q000235:genetics / Q000378:metabolism*; D012867:Skin / Q000378:metabolism* / Q000382:microbiology*; D013207:Staphylococcal Skin Infections / Q000378:metabolism / Q000382:microbiology* / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000378:metabolism
chemical_list: D005990:Glycerol