title: OCT4 and the acquisition of oocyte developmental competence during folliculogenesis.
abstract: The role that the transcription factor OCT4 plays during oocyte growth is yet unknown. In this review, we summarise the data on its potential role in the acquisition of oocyte developmental competence in the mouse. These studies describe the presence in MII oocytes and 2-cell embryos of an OCT4 transcriptional network that might be part of the molecular signature of maternal origin on which the inner cell mass and the embryonic stem cell-associated pluripotency is assembled and shaped. The Oct4-gene regulatory network thus provides a connection between eggs, early preimplantation embryos and embryonic stem cells.
authors: Dipartimento di Scienze Biomediche, Biotecnologiche e Traslazionali, Universitá degli Studi di Parma, Via Volturno 39, Parma, Italy. maurizio.zuccotti@unipr.it
authors: Maurizio
authors: M
authors: Zuccotti
authors: Valeria
authors: V
authors: Merico
authors: Martina
authors: M
authors: Belli
authors: Francesca
authors: F
authors: Mulas
authors: Lucia
authors: L
authors: Sacchi
authors: Blaz
authors: B
authors: Zupan
authors: Carlo Alberto
authors: CA
authors: Redi
authors: Alessandro
authors: A
authors: Prigione
authors: James
authors: J
authors: Adjaye
authors: Riccardo
authors: R
authors: Bellazzi
authors: Silvia
authors: S
authors: Garagna
mesh_terms: D000818:Animals; D001757:Blastomeres / Q000166:cytology / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D051379:Mice; D008957:Models, Genetic; D050814:Octamer Transcription Factor-3 / Q000235:genetics* / Q000378:metabolism; D009865:Oocytes / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D009866:Oogenesis / Q000235:genetics*
chemical_list: D050814:Octamer Transcription Factor-3