title: Toward the next-generation nanomedicines: design of multifunctional multiblock polyurethanes for effective cancer treatment.
abstract: Specific accumulation of therapeutics at tumor sites to improve in vivo biodistribution and therapeutic efficacy of anticancer drugs is a major challenge for cancer therapy. Herein, we demonstrate a new generation of intelligent nanosystem integrating multiple functionalities in a single carrier based on multifunctional multiblock polyurethane (MMPU). The smart nanocarriers equipped with stealth, active targeting, and internalizable properties can ferry paclitaxel selectively into tumor tissue, rapidly enter cancer cells, and controllably release their payload in response to an intracellular acidic environment, thus resulting in an improved biodistribution and excellent antitumor activity in vivo. Our work provides a facile and versatile approach for the design and fabrication of smart intracellular targeted nanovehicles for effective cancer treatment, and opens a new era in the development of biodegradable polyurethanes for next-generation nanodelivery systems.
authors: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
authors: Mingming
authors: M
authors: Ding
authors: Nijia
authors: N
authors: Song
authors: Xueling
authors: X
authors: He
authors: Jiehua
authors: J
authors: Li
authors: Lijuan
authors: L
authors: Zhou
authors: Hong
authors: H
authors: Tan
authors: Qiang
authors: Q
authors: Fu
authors: Qun
authors: Q
authors: Gu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001672:Biocompatible Materials / Q000737:chemistry; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008823:Micelles; D015394:Molecular Structure; D050997:Nanomedicine / Q000639:trends; D053758:Nanoparticles / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D008823:Micelles; D011140:Polyurethanes