title: Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity.
abstract: Microbial transformation of ursolic acid (UA, 3β-hydroxy-urs-12-en-28-oic acid, 1) by filamentous fungus Syncephalastrum racemosum CGMCC 3.2500 was conducted. Five metabolites 3β, 7β, 21β-trihydroxy-urs-12-en-28-oic acid (2); 3β, 21β-dihydroxy-urs-11-en-28-oic acid-13-lactone (3); 1β, 3β, 21β-trihydroxy-urs-12-en-28-oic acid (4); 3β, 7β, 21β-trihydroxy-urs-1-en-28-oic acid-13-lactone (5); and 21-oxo-1β, 3β-dihydroxy-urs-12-en-28-oic acid (6) were afforded. Elucidation of the structures of these metabolites was primarily based on 1D and 2D NMR and HR-MS data. Metabolite 2 was a new compound. In addition, the anti-HCV activity of compounds 1-6 was evaluated.
authors: Institute of Medical Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
authors: Shao-Bin
authors: SB
authors: Fu
authors: Jun-Shan
authors: JS
authors: Yang
authors: Jin-Long
authors: JL
authors: Cui
authors: Di-An
authors: DA
authors: Sun
mesh_terms: D001688:Biological Products / Q000378:metabolism* / Q000494:pharmacology; D001711:Biotransformation; D016174:Hepacivirus / Q000187:drug effects; D015394:Molecular Structure; D009090:Mucorales / Q000378:metabolism*; D014315:Triterpenes / Q000378:metabolism* / Q000494:pharmacology; D000097245:Ursolic Acid
chemical_list: D001688:Biological Products; D014315:Triterpenes; D000097245:Ursolic Acid