title: [Effects of SUMOylation on the subcellular localization and function of DAXX].
abstract: Death domain-associated protein (DAXX) as a multifunctional nuclear protein widely resides in nucleolus, nucleoplasm, chromatin, promyelocytic leukaemia nuclear bodies (PML-NBs) and cytoplasm. It plays significant roles in transcriptional regulation, apoptosis, cell cycle and other biological activities. Small ubiquitin-like modifier (SUMO) is required for SUMOylation which is a highly conserved post-translational modification in a wide variety of cellular processes. Numerous studies demonstrated that SUMOylation has a great effect on the subcellular localization and functional regulation of DAXX. This review will provide a summary for SUMOylation of DAXX.
authors: Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China.
authors: Ling
authors: L
authors: Li
authors: Juan
authors: J
authors: Wen
authors: Qin-Hui
authors: QH
authors: Tuo
authors: Duan-Fang
authors: DF
authors: Liao
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D056970:Co-Repressor Proteins; D005786:Gene Expression Regulation; D006801:Humans; D018832:Molecular Chaperones; D009687:Nuclear Proteins / Q000502:physiology*; D058207:Sumoylation
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D056970:Co-Repressor Proteins; C106985:DAXX protein, human; D018832:Molecular Chaperones; D009687:Nuclear Proteins