title: Laparoscopic radical prostatectomy plus extended lymph nodes dissection for cases with non-extra node metastatic prostate cancer: 5-year experience in a single Chinese institution.
abstract: OBJECTIVE
  To investigate the functional and oncologic outcomes of patients with locally advanced or lymph node metastatic prostate cancer (PCa) treated by laparoscopic radical prostatectomy (LRP) in a single Chinese institution.
  
  
  METHODS
  From June 2004 to June 2011, a total of 152 cases including 105 locally advanced PCa and 47 lymph node metastatic PCa who were treated by LRP with extended lymph node dissection (ePLND) were enrolled in this study. Surgical records, urinary continence, complications, and oncologic outcomes were presented.
  
  
  RESULTS
  The mean operation time and bleeding were 240 min and 110 ml, respectively. After 12-87 months (median 48 m) of follow-up, 91.4 and 94.7 % of the patients were urinary continence at 6 and 12 m, respectively. Eighty biochemical recurrent diseases were observed. The 3- and 5-year biochemical progression-free survival rates were 59.2 and 47.3 %, respectively. Multivariate analysis showed that Gleason score (HR: 1.66, 95 % CI: 1.05-2.64, P = 0.031), pathological stage (HR: 1.64, 95 % CI: 1.2-2.23, P = 0.002), and surgical margin status (HR: 1.75, 95 % CI: 1.04-2.95, P = 0.035) were independent predictive factors for subsequent biochemical relapse. The 3- and 5-year overall and cancer-specific survival rates were 90.2, 86.0 and 95.8, 92.3 %, respectively. There were no significant differences in biochemical recurrence-free (42.6 vs. 49.5 %, P = 0.491), overall (83.4 vs. 87.3 % P = 0.503), and cancer-specific survival rates (92.3 vs. 94.9 %, P = 0.801) between lymph node-positive and -negative PCa.
  
  
  CONCLUSIONS
  With favorable functional and oncologic outcomes in this cohort of 152 patients, we concluded that LRP plus ePLND is feasible for patients with locally advanced non-extra node metastatic PCa.
authors: Department of Urology, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630 Guangdong, People's Republic of China.
authors: Ming-Kun
authors: MK
authors: Chen
authors: Yun
authors: Y
authors: Luo
authors: Hao
authors: H
authors: Zhang
authors: Jiang-Guang
authors: JG
authors: Qiu
authors: Xin-Qiao
authors: XQ
authors: Wen
authors: Jun
authors: J
authors: Pang
authors: Jie
authors: J
authors: Si-Tu
authors: Qi-Peng
authors: QP
authors: Sun
authors: Xin
authors: X
authors: Gao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D002681:China; D006801:Humans; D010535:Laparoscopy; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009367:Neoplasm Staging; D011468:Prostatectomy / Q000009:adverse effects; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D012008:Recurrence; D016019:Survival Analysis; D016896:Treatment Outcome