title: Hypothermia induced by adenosine 5'-monophosphate attenuates early stage injury in an acute gouty arthritis rat model.
abstract: To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hypothermia induced by 5'-AMP could be effectively inhibit the inflammation on acute gouty arthritis in rats. AMP-induced hypothermia has protective effects on our acute gouty arthritis, which was demonstrated by the following criteria: (1) a significant reduction in the ankle swelling (p < 0.001); (2) a significant decrease in the occurrence of leukocyte infiltration and mild hemorrhage; (3) a significant reduction in the presence of serum Interleukin-1β (IL-1β, p < 0.001) and metalloproteinase-9 (MMP-9, p < 0.001); and (4) a significant inhibition in the Nuclear Factor -κappaB (NF-κB) activity (p < 0.001). AMP-induced hypothermia could inhibit acute inflammation reaction and protect the synovial tissue against acute injury in a rat acute gouty arthritis model.
authors: Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX 77030, USA.
authors: Zhimin
authors: Z
authors: Miao
authors: Weiting
authors: W
authors: Guo
authors: Shulai
authors: S
authors: Lu
authors: Wenshan
authors: W
authors: Lv
authors: Changgui
authors: C
authors: Li
authors: Yangang
authors: Y
authors: Wang
authors: Shihua
authors: S
authors: Zhao
authors: Shengli
authors: S
authors: Yan
authors: Zhenyin
authors: Z
authors: Tao
authors: Yunlong
authors: Y
authors: Wang
mesh_terms: D000818:Animals; D000843:Ankle Joint / Q000378:metabolism / Q000473:pathology; D015210:Arthritis, Gouty / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D004195:Disease Models, Animal; D033461:Hyperuricemia / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D007036:Hypothermia, Induced / Q000379:methods*; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D016328:NF-kappa B / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology; D014527:Uric Acid
chemical_list: D053583:Interleukin-1beta; D016328:NF-kappa B; D014527:Uric Acid; D020780:Matrix Metalloproteinase 9