title: Vascular networks due to dynamically arrested crystalline ordering of elongated cells.
abstract: Recent experimental and theoretical studies suggest that crystallization and glass-like solidification are useful analogies for understanding cell ordering in confluent biological tissues. It remains unexplored how cellular ordering contributes to pattern formation during morphogenesis. With a computational model we show that a system of elongated, cohering biological cells can get dynamically arrested in a network pattern. Our model provides an explanation for the formation of cellular networks in culture systems that exclude intercellular interaction via chemotaxis or mechanical traction.
authors: Centrum Wiskunde & Informatica, Amsterdam, The Netherlands. M.M.Palm@cwi.nl
authors: Margriet M
authors: MM
authors: Palm
authors: Roeland M H
authors: RM
authors: Merks
mesh_terms: D000818:Animals; D003198:Computer Simulation; D042783:Endothelial Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D055806:Microvessels / Q000033:anatomy & histology* / Q000502:physiology*; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D009024:Morphogenesis / Q000502:physiology*