title: 18F-Fluoride PET/CT allows detection of hyperostosis and osseous involvement in meningioma: initial experience.
abstract: OBJECTIVE
  The present study was conducted to assess the diagnostic performance of (18)F-fluoride PET/CT in evaluating hyperostosis and osseous involvement in patients with meningioma.
  
  
  METHODS
  Thirty-four patients with meningioma (mean age, 61 years) underwent (18)F-fluoride PET/CT before surgery. In 24 patients (71%), (18)F-FDG PET/CT was also given before surgery, and the results were compared. The images were reviewed by 2 board-certified nuclear medicine specialists who were unaware of any clinical information and a consensus was reached. Uptake patterns and measurements of tracers were compared with pathological findings from resected specimens, with hyperostosis and osseous involvement as the reference standard.
  
  
  RESULTS
  There were 27 grade I tumors (79%) and 7 grade II tumors (21%). The primary tumor focus was identified in each patient using both (18)`F-fluoride PET/CT and (18)F-FDG PET/CT, but there were no significant correlations in the degree of uptake between the 2 tracers. The SUV(max), SUV(max) corrected for lean body mass (SUL(max)), and tumor metabolic volume (TMV) for (18)F-fluoride and (18)F-FDG were greater in grade II tumors than in grade I tumors. Hyperostosis and osseous involvement was identified in 12 tumors (38%). The SUV(max), SUL(max), and TMV of tumors visualized with (18)F-fluoride PET/CT were greater in tumors with hyperostosis and osseous involvement than in those without (P = 0.005, P = 0.003, and P = 0.006, respectively). In contrast, the SUV(max), SUL(max), and TMV of tumors visualized with (18)F-FDG PET/CT were similar regardless of hyperostosis or osseous involvement.
  
  
  CONCLUSIONS
  (18)F-fluoride PET/CT may improve detection of hyperostosis and osseous involvement in patients with meningioma.
authors: Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan. utateish@yokohama-cu.ac.jp
authors: Ukihide
authors: U
authors: Tateishi
authors: Kensuke
authors: K
authors: Tateishi
authors: Kazuya
authors: K
authors: Shizukuishi
authors: Ayako
authors: A
authors: Shishikura
authors: Hidetoshi
authors: H
authors: Murata
authors: Tomio
authors: T
authors: Inoue
authors: Nobutaka
authors: N
authors: Kawahara
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D005260:Female; D005459:Fluorides; D005462:Fluorine Radioisotopes; D006801:Humans; D015576:Hyperostosis / Q000150:complications / Q000000981:diagnostic imaging*; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; D005459:Fluorides