title: Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects.
abstract: OBJECTIVE
  Fat-mass and obesity-associated (FTO) gene is known to be involved in the pathophysiology of obesity and a single-nucleotide polymorphism (SNP) rs9939609 of FTO gene is repeatedly confirmed to be associated with body mass index (BMI) and obesity. The aim of this study is to elucidate effects of FTO gene polymorphism on BMI in Japanese patients with schizophrenia and healthy subjects.
  
  
  METHODS
  Three hundred fifty one patients with schizophrenia and 342 age- and sex-matched healthy subjects participated in the study. Information on BMI and antipsychotic medication was also collected from patients and healthy subjects. Genotype of the FTO SNP rs9939609 was determined by TaqMan SNP Genotyping Assays.
  
  
  RESULTS
  There was no significant difference in BMI between patients and healthy subjects. No significant difference in BMI was observed among any medications. We observed no significant difference in rs9939609 allele frequencies between patients and healthy subjects. There was a significant difference in BMI between healthy subjects with risk (AA or TA) genotypes and those with TT genotype. We also observed a significant positive correlation between the number of risk allele (A allele) and BMI in healthy subjects.
  
  
  CONCLUSIONS
  Our study suggested that FTO rs9939609 polymorphism might have some impacts on the BMI in healthy subjects, but might not have same impacts on the BMI of patients with schizophrenia.
authors: Department of Psychiatry, Course of Integrated Brain Sciences, University of Tokushima School of Medicine, Tokushima, Japan.
authors: Shin-Ya
authors: SY
authors: Watanabe
authors: Jun-Ichi
authors: J
authors: Iga
authors: Shusuke
authors: S
authors: Numata
authors: Masahito
authors: M
authors: Nakataki
authors: Toshihito
authors: T
authors: Tanahashi
authors: Mitsuo
authors: M
authors: Itakura
authors: Tetsuro
authors: T
authors: Ohmori
keywords: Antipsychotics agents; Body mass index; Fat-mass and obesity-associated; Gene association studies; Schizophrenia