title: New pyran-2-ones from alkalophilic actinomycete, Nocardiopsis alkaliphila sp. Nov. YIM-80379.
abstract: Two new pyran-2-ones, nocardiopyrones A and B (1 and 2, resp.), along with four known compounds, pyridinols 3-5, and 1-acetyl-β-carboline (6) were isolated from the alkalophilic actinomycete Nocardiopsis alkaliphila sp. nov. YIM-80379. Their structures were established on the basis of spectroscopic analysis, CD spectra, and the quantum-chemical ECD calculation. Pyridinols 3-5 were isolated from a natural source for the first time. Compounds 1 and 2 showed weak antibacterial activities against Pseudomonas aeruginosa, Enterobacter aerogenes, and Escherichia coli with MIC values of 20-48 μM. Compound 2 showed weak antimicrobial activities against Candida albicans and Staphylococcus aureus with MIC values of 24 and 48 μM, respectively.
authors: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
authors: Zhiying
authors: Z
authors: Wang
authors: Peng
authors: P
authors: Fu
authors: Peipei
authors: P
authors: Liu
authors: Pei
authors: P
authors: Wang
authors: Jiabo
authors: J
authors: Hou
authors: Wenjun
authors: W
authors: Li
authors: Weiming
authors: W
authors: Zhu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy; D002942:Circular Dichroism; D021902:Enterobacter aerogenes / Q000187:drug effects; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000737:chemistry*; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011753:Pyrones