title: Bilateral pallidal stimulation in cervical dystonia: blinded evidence of benefit beyond 5 years.
abstract: The local injection of botulinum toxin is accepted as the first-line treatment of primary cervical dystonia. This approach provides adequate symptomatic relief for most patients, but up to one-third will have an unsatisfactory response. Deep brain stimulation of the globus pallidus internus has been increasingly used in dystonic syndromes that are refractory to best pharmacological approaches. Although cervical dystonia is the most common idiopathic focal dystonia, evidence for long-term responsiveness to pallidal stimulation is limited. The primary objective of this study was to prospectively collect outcome data from baseline to last clinical follow-up on patients with idiopathic cervical dystonia treated with bilateral pallidal stimulation. Blinded video assessment of examinations performed preoperatively and at last video assessment were performed. Ten patients had complete prospective clinical follow-up. Baseline total Toronto Western Spasmodic Torticollis Rating Scale score (±standard deviation) was 54.5 ± 12.4 (range, 35.0-70.3). Comparison of the blinded severity sub-score on baseline video and at last video assessment at a mean of 7.7 years postoperatively demonstrated a mean improvement of 47.6% (P = 0.002) and strong inter-observer correlation between blinded raters (Spearman r = 0.78, 95% confidence interval 0.49-0.92, P = 0.0001). All 10 patients had 5 years of open prospective follow-up, documenting a 47.4 ± 26.4% (P < 0.01) mean improvement with respect to baseline. This was maintained at a mean of 7.8 years at last follow-up after surgery (range, 4.9-10.7 years) with a 54.4 ± 27.4% mean improvement (P < 0.01). Deep brain stimulation of the globus pallidus is an effective and long-lasting second-line treatment of cervical dystonia, with benefit in some of our patients extending to >10 years. More data are needed to explain variations in individual responses and to guide individual programming parameters.
authors: Movement Disorders Unit, Department of Psychiatry and Neurology, University Hospital Centre of Grenoble, 38043 Grenoble Cedex 09, France.
authors: Richard A
authors: RA
authors: Walsh
authors: Christos
authors: C
authors: Sidiropoulos
authors: Andres M
authors: AM
authors: Lozano
authors: Mojgan
authors: M
authors: Hodaie
authors: Yu-Yan
authors: YY
authors: Poon
authors: Melanie
authors: M
authors: Fallis
authors: Elena
authors: E
authors: Moro
mesh_terms: D046690:Deep Brain Stimulation; D005260:Female; D005500:Follow-Up Studies; D005917:Globus Pallidus; D006801:Humans; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D014103:Torticollis / Q000628:therapy*; D016896:Treatment Outcome