title: Rocuronium-sugammadex decreases the severity of post-electroconvulsive therapy agitation.
abstract: A 51-year-old male patient with a diagnosis of refractory major depressive disorder and unresponsive to antidepressants underwent 8 sessions of electroconvulsive therapy (ECT) every 48 hours. Succinylcholine was used for muscle relaxation until the sixth ECT session, and midazolam was administered for severe emergence agitation that recurred after each session. In the sixth ECT session, rocuronium, 0.4 mg/kg, was used for muscle relaxation and sugammadex, 2 mg/kg, for reversal of muscle paralysis. Subsequently, a clear decrease in post-ECT agitation was observed. We suggest that this combination might be a safe and effective alternative to succinylcholine for post-ECT agitation.
authors: Department of Anesthesiology, Ankara Numune Training and Research Hospital, Ankara, Turkey. aysunposta@yahoo.com
authors: Aysun
authors: A
authors: Postaci
authors: Civan
authors: C
authors: Tiryaki
authors: Ozlem
authors: O
authors: Sacan
authors: Dilsen
authors: D
authors: Ornek
authors: Merve
authors: M
authors: Kalyoncu
authors: Bayazit
authors: B
authors: Dikmen
mesh_terms: D000732:Androstanols / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000150:complications / Q000628:therapy; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D004569:Electroencephalography; D006801:Humans; D006993:Hypnotics and Sedatives; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008874:Midazolam / Q000627:therapeutic use; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000209:etiology*; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000627:therapeutic use*
chemical_list: D000732:Androstanols; D006993:Hypnotics and Sedatives; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D019344:Lactic Acid; D000077122:Sugammadex; D008874:Midazolam; D000077123:Rocuronium