title: Synthesis of 1H-1,2,3-triazoles and study of their antifungal and cytotoxicity activities.
abstract: We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr, Candida tropicalis, Candida dubliniensis, Tricophyton rubrum, Microporum canis and Aspergillus niger. All of the 1,2,3-triazoles were prepared from 1,3-dipolar cyclizations between aryl azides and alkynes catalyzed by Cu(I), and several of the compounds exhibited antifungal activity with low cytotoxicity. The results demonstrated the potential and importance of developing new 1,2,3-triazoles compounds with antifungal activity.
authors: Universidade Federal Fluminense, Departamento de Quimica Organi ca, Intituto de Quimica, de Valonguinho, 24020, Niteroi, RJ, Brazil. gqofernando@vm.uff.br.
authors: Iara F
authors: IF
authors: da Silva
authors: Prisicila R C
authors: PR
authors: Martins
authors: Emanuelly G
authors: EG
authors: da Silva
authors: Sabrina B
authors: SB
authors: Ferreira
authors: Vitor F
authors: VF
authors: Ferreira
authors: Karen Regina C
authors: KR
authors: da Costa
authors: Marne C
authors: MC
authors: de Vasconcellos
authors: Emerson S
authors: ES
authors: Lima
authors: Fernando de C
authors: Fde C
authors: da Silva
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D001234:Aspergillus niger / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D014230:Triazoles