title: Prognostic significance of USP22 as an oncogene in papillary thyroid carcinoma.
abstract: Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, has been associated with metastasis, therapy resistance, and cell cycle progression. The purpose of this study was to investigate the expression level of USP22 in papillary thyroid carcinoma (PTC) samples and to evaluate its clinical significance in PTC patients. USP22 expression was examined in 30 fresh PTC tissues and paired adjacent noncancerous tissues by real-time quantitative RT-PCR. Immunohistochemistry for USP22 was performed on additional 156 PTC tissues. The clinical significance of USP22 expression was analyzed. We found that the expression levels of USP22 mRNA and protein in PTC tissues were both significantly higher than those in noncancerous tissues. Clinicopathological analysis showed that USP22 expression was significantly correlated with tumor size (p=0.036), extracapsular invasion (p=0.012), multifocality (p=0.014), lymph node metastasis (p=0.022), distant metastasis (p=0.005), and TNM stage (p=0.002). The Kaplan-Meier survival curves revealed that USP22 expression was associated with poor prognosis in PTC patients. USP22 expression was an independent prognostic marker of overall patient survival in a multivariate analysis. Our findings suggest that USP22 is an independent predictor of poor prognosis of PTC patients.
authors: Department of Vascular and Endocrine Surgery, Xijing Hospital, The Fourth Military Medical University, No. 127, Changle West Rd., Xi'an, 710032, Shanxi Province, China.
authors: Hui
authors: H
authors: Wang
authors: Yong-Ping
authors: YP
authors: Li
authors: Jiang-Hao
authors: JH
authors: Chen
authors: Shi-Fang
authors: SF
authors: Yuan
authors: Ling
authors: L
authors: Wang
authors: Ju-Liang
authors: JL
authors: Zhang
authors: Qing
authors: Q
authors: Yao
authors: Nan-Lin
authors: NL
authors: Li
authors: Jie-Fang
authors: JF
authors: Bian
authors: Jing
authors: J
authors: Fan
authors: Jun
authors: J
authors: Yi
authors: Rui
authors: R
authors: Ling
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009857:Oncogenes; D011379:Prognosis; D015996:Survival Rate; D013869:Thiolester Hydrolases / Q000235:genetics* / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D043222:Ubiquitin Thiolesterase
chemical_list: D014408:Biomarkers, Tumor; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; C527170:Usp22 protein, human