title: Unbalanced neuronal circuits in addiction.
abstract: Through sequential waves of drug-induced neurochemical stimulation, addiction co-opts the brain's neuronal circuits that mediate reward, motivation to behavioral inflexibility and a severe disruption of self-control and compulsive drug intake. Brain imaging technologies have allowed neuroscientists to map out the neural landscape of addiction in the human brain and to understand how drugs modify it.
authors: National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, United States. nvokowl@nida.nih.gov
authors: Nora D
authors: ND
authors: Volkow
authors: Gen-Jack
authors: GJ
authors: Wang
authors: Dardo
authors: D
authors: Tomasi
authors: Ruben D
authors: RD
authors: Baler
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D002491:Central Nervous System Agents / Q000009:adverse effects; D006801:Humans; D009415:Nerve Net / Q000187:drug effects / Q000473:pathology*; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D019966:Substance-Related Disorders / Q000473:pathology*
chemical_list: D002491:Central Nervous System Agents