title: MiR-155 at the heart of oncogenic pathways.
abstract: MicroRNAs are increasingly being recognized as oncogenes and tumor suppressors in cancer. MicroRNA-155 (miR-155) is an established oncomiR in breast cancer and regulates several pro-oncogenic pathways. In light of this, Chiang's group has discovered a novel pathway regulated by miR-155. MiR-155 directly targets the VHL tumor suppressor and, by doing so, promotes the activity of HIF transcription factors and angiogenesis. This pathway appears to be particularly relevant in triple-negative breast cancer.
authors: 1] Department of Cancer Biology, The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH, USA [2] VA Research Service, Department of Veterans Affairs, Cincinnati, OH, USA.
authors: M F
authors: MF
authors: Czyzyk-Krzeska
authors: Department of Cancer Biology, The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors: X
authors: X
authors: Zhang
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D064726:Triple Negative Breast Neoplasms / Q000098:blood supply* / Q000235:genetics*; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics*
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs; D051794:Von Hippel-Lindau Tumor Suppressor Protein; C497446:VHL protein, human