title: Comparison study of ferrofluid and powder iron oxide nanoparticle permeability across the blood-brain barrier.
abstract: In the present study, the permeability of 11 different iron oxide nanoparticle (IONP) samples (eight fluids and three powders) was determined using an in vitro blood-brain barrier model. Importantly, the results showed that the ferrofluid formulations were statistically more permeable than the IONP powder formulations at the blood-brain barrier, suggesting a role for the presently studied in situ synthesized ferrofluid formulations using poly(vinyl) alcohol, bovine serum albumin, collagen, glutamic acid, graphene, and their combinations as materials which can cross the blood-brain barrier to deliver drugs or have other neurological therapeutic efficacy. Conversely, the results showed the least permeability across the blood-brain barrier for the IONP with collagen formulation, suggesting a role as a magnetic resonance imaging contrast agent but limiting IONP passage across the blood-brain barrier. Further analysis of the data yielded several trends of note, with little correlation between permeability and fluid zeta potential, but a larger correlation between permeability and fluid particle size (with the smaller particle sizes having larger permeability). Such results lay the foundation for simple modification of iron oxide nanoparticle formulations to either promote or inhibit passage across the blood-brain barrier, and deserve further investigation for a wide range of applications.
authors: School of Engineering, Brown University, Providence, RI, USA.
authors: Dan
authors: D
authors: Hoff
authors: Lubna
authors: L
authors: Sheikh
authors: Soumya
authors: S
authors: Bhattacharya
authors: Suprabha
authors: S
authors: Nayar
authors: Thomas J
authors: TJ
authors: Webster
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability; D002470:Cell Survival / Q000187:drug effects; D003911:Dextrans / Q000008:administration & dosage / Q000737:chemistry; D042783:Endothelial Cells / Q000378:metabolism; D005290:Ferric Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D016650:Fluorescein-5-isothiocyanate / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D059346:Magnets / Q000737:chemistry*; D051379:Mice; D008954:Models, Biological; D010316:Particle Size; D011142:Polyvinyl Alcohol / Q000008:administration & dosage / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D003911:Dextrans; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C015219:fluorescein isothiocyanate dextran; C000499:ferric oxide; D012710:Serum Albumin, Bovine; D011142:Polyvinyl Alcohol; D016650:Fluorescein-5-isothiocyanate
keywords: blood-brain barrier; ferrofluids; iron oxide nanoparticles; permeability