title: Unsuccessful switch from insulin to sulfonylurea therapy in permanent neonatal diabetes mellitus due to an R201H mutation in the KCNJ11 gene: a case report.
abstract: Mutations in KCNJ11 are a common cause of permanent neonatal diabetes mellitus. Previously, all patients carrying an R201H mutation in the KCNJ11 gene showed successful switches from insulin to sulfonylurea. Here, we report an unsuccessful switch in an 18-year-old patient carrying the common R201H mutation in the KCNJ11 gene.
authors: Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, 26 Kangwondaehak-gil, Chuncheon-si, Gangwon-do 200-701, Republic of Korea.
authors: Jeong Won
authors: JW
authors: Heo
authors: Sang-Wook
authors: SW
authors: Kim
authors: Eun-Hee
authors: EH
authors: Cho
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D001120:Arginine; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D005905:Glyburide / Q000627:therapeutic use*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006639:Histidine; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D020125:Mutation, Missense / Q000235:genetics*; D024661:Potassium Channels, Inwardly Rectifying / Q000097:blood / Q000235:genetics*; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D017211:Treatment Failure; D000099161:Kcnj11 Channel
chemical_list: D001120:Arginine; D001786:Blood Glucose; D005905:Glyburide; D006442:Glycated Hemoglobin; D006639:Histidine; D007004:Hypoglycemic Agents; D007328:Insulin; D024661:Potassium Channels, Inwardly Rectifying; D013453:Sulfonylurea Compounds; D000099161:Kcnj11 Channel; C517652:hemoglobin A1c protein, human