title: Super, red palm and palm oleins improve the blood pressure, heart size, aortic media thickness and lipid profile in spontaneously hypertensive rats.
abstract: BACKGROUND
  Oleic acid has been shown to lower high blood pressure and provide cardiovascular protection. Curiosity arises as to whether super olein (SO), red palm olein (RPO) and palm olein (PO), which have high oleic acid content, are able to prevent the development of hypertension.
  
  
  RESULTS
  Four-week-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were fed 15% SO, RPO or PO supplemented diet for 15 weeks. After 15 weeks of treatment, the systolic blood pressure (SBP) of SHR treated with SO, RPO and PO were 158.4±5.0 mmHg (p<0.001), 178.9±2.7 mmHg (p<0.001) and 167.7±2.1 mmHg (p<0.001), respectively, compared with SHR controls (220.9±1.5 mmHg). Bradycardia was observed with SO and PO. In contrast, the SBP and heart rate of treated WKY rats were not different from those of WKY controls. The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter. No such differences, however, were observed between the treated and untreated WKY rats. Oil Red O enface staining of thoracic-abdominal aorta did not show any lipid deposition in all treated rats. The SO and RPO significantly raised serum alkaline phosphatase levels in the SHR while body weight and renal biochemical indices were unaltered in both strains. Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.
  
  
  CONCLUSIONS
  The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO. The SO and RPO are antiatherogenic in nature by improving blood lipid profiles in SHR.
authors: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors: Chee-Meng
authors: CM
authors: Boon
authors: Mei-Han
authors: MH
authors: Ng
authors: Yuen-May
authors: YM
authors: Choo
authors: Shiueh-Lian
authors: SL
authors: Mok
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000473:pathology*; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism; D006321:Heart / Q000033:anatomy & histology* / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007677:Kidney Function Tests; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D009929:Organ Size; D000073878:Palm Oil; D010938:Plant Oils / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR; D013599:Systole / Q000187:drug effects; D017540:Tunica Media
chemical_list: D002316:Cardiotonic Agents; D005227:Fatty Acids; D008055:Lipids; D009829:Oleic Acids; D010938:Plant Oils; D000073878:Palm Oil