title: FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma.
abstract: BACKGROUND
  FK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma.
  
  
  OBJECTIVE
  To examine the role of FKBP5-trauma interactions in the partly stress-related psychosis phenotype.
  
  
  METHODS
  In 401 general population twins, four functional polymorphisms were examined in models of psychosis and cortisol, and followed up in models of psychosis in three samples at different familial liability (175 controls, 200 unaffected siblings and 195 patients with a psychotic disorder).
  
  
  RESULTS
  The most consistent finding was an interaction between childhood trauma and rs9296158/rs4713916 on psychotic symptoms and cortisol in the twin sample, combined with a directionally similar interaction in siblings (rs4713916) and patients (rs9296158), A-allele carriers at both polymorphisms being most vulnerable to trauma.
  
  
  CONCLUSIONS
  Trauma may increase the risk of psychosis through enduring changes in the cortisol feedback loop, similar to that for PTSD, suggesting comparable biological mechanisms for psychosis across diagnostic boundaries.
authors: Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors: Dina
authors: D
authors: Collip
authors: Inez
authors: I
authors: Myin-Germeys
authors: Marieke
authors: M
authors: Wichers
authors: Nele
authors: N
authors: Jacobs
authors: Catherine
authors: C
authors: Derom
authors: Evert
authors: E
authors: Thiery
authors: Tineke
authors: T
authors: Lataster
authors: Claudia
authors: C
authors: Simons
authors: Philippe
authors: P
authors: Delespaul
authors: Machteld
authors: M
authors: Marcelis
authors: Jim
authors: J
authors: van Os
authors: Ruud
authors: R
authors: van Winkel
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011618:Psychotic Disorders / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D012463:Saliva / Q000378:metabolism; D035781:Siblings / Q000523:psychology; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D014947:Wounds and Injuries / Q000150:complications / Q000523:psychology*; D000099159:Tacrolimus Binding Protein 5
chemical_list: D006854:Hydrocortisone; D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5