title: Bile Acid Receptors and Liver Cancer.
abstract: Liver cancer, particularly hepatocellular carcinoma (HCC), is the third leading cause of cancer death in the world. Bile acids (BAs) are liver-produced amphipathic molecules that are required to facilitate the absorption of cholesterol, fat-soluble vitamins, and lipids in the intestine. However, BAs are also known to act as potential carcinogens and deregulation of BA homeostasis has been linked to HCC formation. Two key BA receptors, farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5), were recently identified, which provides great insights into BAs' normal physiological functions as well as their carcinogenic effects. In this review, we focus on the potential links among BAs, two BA receptors, and HCC. FXR and TGR5 not only play key roles in regulating BA homeostasis but also are essential in suppressing BAs' carcinogenic effects on liver cancer.
authors: Division of Cellular and Molecular Diabetes, Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA.
authors: Xichun
authors: X
authors: Wang
authors: Xianghui
authors: X
authors: Fu
authors: Carl
authors: C
authors: Van Ness
authors: Zhipeng
authors: Z
authors: Meng
authors: Xiaoxiao
authors: X
authors: Ma
authors: Wendong
authors: W
authors: Huang
keywords: Bile acids; FXR; Inflammation; Liver cancer; Metabolism; TGR5