title: A Ni-free ZrCuFeAlAg bulk metallic glass with potential for biomedical applications.
abstract: The mechanical properties and biocompatibility of an Ni-free Zr-based bulk metallic glass (BMG) Zr60.14Cu22.31Fe4.85Al9.7Ag3 were investigated in detail to evaluate its potential as a biomaterial. The BMG was found to have a low Young's modulus of 82±1.9GPa, a high strength of 1720±28MPa and a high fracture toughness of 94±19MPam(1/2), as well as good fatigue strength over 400MPa. The corrosion behavior of the alloy was investigated in simulated body fluid (SBF) by electrochemical measurements, which indicates that the Zr-based BMG has a better corrosion resistance than pure Zr and Ti6Al4V. X-ray photoelectron spectroscopy analysis revealed that the passive film formed on the BMG surface is enriched in Al- and Zr-oxides, which could account for the good corrosion resistance of the BMG. On the other hand, metal ion release of the BMG in SBF was determined by inductively coupled plasma mass spectrometry after the BMG was immersed in SBF at 37°C for 30days, showing a ppb (ngml(-1)) level of metal ion release. The in vitro test via cell culture indicates that the BMG exhibits a cytotoxicity of Grade 0-1, which is as good as Ti6Al4V alloy. Cell adhesion morphological analysis shows that the cells were flattened and well spread out on the surfaces of the BMG, showing that the BMG had good biocompatibility. The combination of good mechanical properties and biocompatibility demonstrates that the Ni-free Zr-based BMG studied in this work is a good candidate for a new type of load-bearing biomedical material.
authors: School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.
authors: Yan
authors: Y
authors: Liu
authors: Yi-Mei
authors: YM
authors: Wang
authors: Hui-Fang
authors: HF
authors: Pang
authors: Qiu
authors: Q
authors: Zhao
authors: Lin
authors: L
authors: Liu
mesh_terms: D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry* / Q000633:toxicity*; D001826:Body Fluids / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects*; D003343:Corrosion; D055119:Elastic Modulus; D005898:Glass / Q000032:analysis / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008670:Metals / Q000032:analysis / Q000737:chemistry* / Q000633:toxicity*; D009532:Nickel / Q000032:analysis / Q000737:chemistry / Q000633:toxicity*; D012516:Osteosarcoma / Q000473:pathology / Q000503:physiopathology; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008670:Metals; D009532:Nickel