title: Adult-onset asthma associated with periocular xanthogranuloma: new diagnostic and therapeutic approaches in a very rare systemic disease.
abstract: OBJECTIVE
  To report some novel findings concerning the systemic manifestations and treatment of adult-onset asthma and periocular xanthogranuloma, a rare type of non-Langerhans histiocytosis that can lead to important visual dysfunction.
  
  
  METHODS
  A retrospective case series of 2 patients was evaluated for orbital and systemic manifestations using fluorodeoxyglucose positron emission tomography/CT and/or orbital MRI. Histological specimens were reviewed in all patients. Oral prednisone was initiated at 1 mg/kg daily and gradually tapered to a minimum effective dose. Efficacy was assessed on the basis of an objective observation of decreased swelling.
  
  
  RESULTS
  One patient displayed original uptake foci involving intrathoracic lymphadenopathies, the trajectory of the paraumbilical vein and perirectal fat. Low-dose prednisone was able to induce a durable response in the authors' patients.
  
  
  CONCLUSIONS
  Fluorodeoxyglucose positron emission tomography/CT may be useful for the diagnostic workup and follow-up assessment of patients with adult-onset asthma and periocular xanthogranuloma. Oral corticosteroids can be used successfully as first-line treatment in such patients.
authors: Service de Médecine Interne, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Bobigny, France.
authors: Jonathan
authors: J
authors: London
authors: Michael
authors: M
authors: Soussan
authors: Thomas
authors: T
authors: Gille
authors: Isabelle
authors: I
authors: Badelon
authors: Ursula
authors: U
authors: Warzocha
authors: Olivier
authors: O
authors: Galatoire
authors: Antoine
authors: A
authors: Martin
authors: Robin
authors: R
authors: Dhote
authors: Sébastien
authors: S
authors: Abad
mesh_terms: D000368:Aged; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000188:drug therapy; D019788:Fluorodeoxyglucose F18; D005938:Glucocorticoids / Q000627:therapeutic use; D006099:Granuloma / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000175:diagnosis* / Q000188:drug therapy; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000627:therapeutic use; D019275:Radiopharmaceuticals; D035583:Rare Diseases; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014973:Xanthomatosis / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D005938:Glucocorticoids; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D011239:Prednisolone