title: Relationship between plasma analytes and SPARE-AD defined brain atrophy patterns in ADNI.
abstract: Different inflammatory and metabolic pathways have been associated with Alzheimeŕs disease (AD). However, only recently multi-analyte panels to study a large number of molecules in well characterized cohorts have been made available. These panels could help identify molecules that point to the affected pathways. We studied the relationship between a panel of plasma biomarkers (Human DiscoveryMAP) and presence of AD-like brain atrophy patterns defined by a previously published index (SPARE-AD) at baseline in subjects of the ADNI cohort. 818 subjects had MRI-derived SPARE-AD scores, of these subjects 69% had plasma biomarkers and 51% had CSF tau and Aβ measurements. Significant analyte-SPARE-AD and analytes correlations were studied in adjusted models. Plasma cortisol and chromogranin A showed a significant association that did not remain significant in the CSF signature adjusted model. Plasma macrophage inhibitory protein-1α and insulin-like growth factor binding protein 2 showed a significant association with brain atrophy in the adjusted model. Cortisol levels showed an inverse association with tests measuring processing speed. Our results indicate that stress and insulin responses and cytokines associated with recruitment of inflammatory cells in MCI-AD are associated with its characteristic AD-like brain atrophy pattern and correlate with clinical changes or CSF biomarkers.
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
authors: Jon B
authors: JB
authors: Toledo
authors: Xiao
authors: X
authors: Da
authors: Priyanka
authors: P
authors: Bhatt
authors: David A
authors: DA
authors: Wolk
authors: Steven E
authors: SE
authors: Arnold
authors: Leslie M
authors: LM
authors: Shaw
authors: John Q
authors: JQ
authors: Trojanowski
authors: Christos
authors: C
authors: Davatzikos
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000097:blood; D053379:Chromogranin A / Q000097:blood; D015331:Cohort Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000097:blood; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood; D008279:Magnetic Resonance Imaging; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D053379:Chromogranin A; D018971:Insulin-Like Growth Factor Binding Protein 2; D008263:Macrophage Migration-Inhibitory Factors; D016875:tau Proteins; D006854:Hydrocortisone