title: Total synthesis of cladoniamide G.
abstract: The total synthesis of cladoniamide G, a cytotoxic compound against MCF-7 breast cancer cells (10 μg/mL), was accomplished. Key steps in the sequence include oxidative dimerization of 3-acetoxy-5-chloroindole and a tandem process incorporating three steps: bimolecular carbonyl addition, lactam formation, and carbamate removal.
authors: Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
authors: Benjamin C
authors: BC
authors: Loosley
authors: Raymond J
authors: RJ
authors: Andersen
authors: Gregory R
authors: GR
authors: Dake
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms; D002219:Carbamates / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007769:Lactams / Q000138:chemical synthesis; D008011:Lichens / Q000382:microbiology; D061986:MCF-7 Cells; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013302:Streptomyces / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D002219:Carbamates; D026121:Indole Alkaloids; D007769:Lactams; C581998:cladoniamide G