title: [Treatment of hemorrhagic dengue in the pediatric population: a systematic review].
abstract: Electronic database Medline, Embase, Cochrane Library and Lilacs were used to retrieve the clinical trials that will evaluate the various therapeutical options available for management of hemorrhagic dengue. Eight clinical studies were included. Supportive care and symptomatic treatment through hydration and aggressive fluid management, if hypotension develops in the course of disease, are the most important aids to improve survival. Treatment with corticosteroids such as methylprednisolone, hydrocortisone, carbazochorome sodium sulfonate (AC-17) and recombinant activated factor VII did not reduce mortality in children with hemorrhagic dengue. At present, no vaccine or effective antiviral treatment is available for the prevention or treatment of hemorrhagic dengue.
authors: Universidad del Rosario, Bogotá, Colombia. amgutier@urosario.edu.co
authors: Angela María
authors: AM
authors: Gutiérrez-Alvarez
authors: Nicolas
authors: N
authors: Medina Silva
authors: María Catalina
authors: MC
authors: Vargas Bazurto
authors: Sindy
authors: S
authors: Montoya Osorio
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000323:Adrenochrome / Q000031:analogs & derivatives / Q000627:therapeutic use; D058633:Antipyretics / Q000627:therapeutic use; D002648:Child; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D003102:Colloids / Q000627:therapeutic use; D003105:Colombia; D003131:Combined Modality Therapy; D000077324:Crystalloid Solutions; D019468:Disease Management; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D015942:Factor VIIa / Q000627:therapeutic use; D005440:Fluid Therapy; D006470:Hemorrhage / Q000188:drug therapy / Q000209:etiology; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D007552:Isotonic Solutions / Q000627:therapeutic use; D010102:Oxygen Inhalation Therapy; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D011994:Recombinant Proteins / Q000627:therapeutic use; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy; D019595:Severe Dengue / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D012769:Shock / Q000209:etiology / Q000628:therapy
chemical_list: D000305:Adrenal Cortex Hormones; D058633:Antipyretics; D003102:Colloids; D000077324:Crystalloid Solutions; D006490:Hemostatics; D007552:Isotonic Solutions; D011994:Recombinant Proteins; D000323:Adrenochrome; C073338:carbazochrome; C103587:recombinant FVIIa; D015942:Factor VIIa