title: Local CD4+, CD8+ and CD56+ T-lymphocite Reaction on Primary Lung Cancer.
abstract: OBJECTIVE
  The primary goal of this study was to determine the difference of abundance of CD4+, CD8+ and CD56+ bronchoalveolar fluid's lymphocytes and their subpopulations between cancerous lung and healthy lung from the same patient.
  
  
  METHODS
  Mini-bronchoalveolar lavage was taken from 55 patients from lung with cancer and healthy lung. After laboratory processing and addition of CD4, CD8, CD27, CD28 and CD56 antibody, the material was analyzed by flow cytometer. Results from lung with cancer were compared to the ones from the healthy lung. The examined patients were the test and the control group at the same time.
  
  
  RESULTS
  CD27+28+ forms of CD4+ and CD8+ lymphocytes are more activated in the cancerous lung compared to healthy lung, while the CD27-28- forms are less activated in diseased lung. CD4+ forms of CD56+ lymphocytes are more activated in cancerous lung compared to the health lung, while the CD8+ forms are less activated in diseased lung.
  
  
  CONCLUSIONS
  Immature helper and cytotoxic T lymphocyte response, as well as regulatory NK and NKT cell response are more activated in cancerous lung compared to the health lung of the same patient.
authors: Policlinic for Pulmonary Diseases, Health Medical Centre Tuzla, Bosnia and Herzegovina ; Medical Faculty, University in Tuzla, Bosnia and Herzegovina.
authors: Edin
authors: E
authors: Jusufovic
authors: Besim
authors: B
authors: Prnjavorac
authors: Ermina
authors: E
authors: Iljazovic
authors: Mitja
authors: M
authors: Kosnik
authors: Dragan
authors: D
authors: Keser
authors: Peter
authors: P
authors: Korosec
authors: Jugoslav
authors: J
authors: Stahov
authors: Edin
authors: E
authors: Zukic
authors: Rifat
authors: R
authors: Sejdinovic
authors: Ekrem
authors: E
authors: Ajanovic
keywords: Bronchoalveolar lavage; CD4+ lymphocytes; CD56+ lymphocytes; CD8+ lymphocytes; Lung cancer.