title: Neural correlates of activities of daily living in frontotemporal dementia.
abstract: BACKGROUND
  Little research to date has investigated neural correlates of functional disability in frontotemporal dementia (FTD).
  
  
  METHODS
  Activities of daily living (ADL) were covaried against gray matter atrophy regions via Voxel-based morphometry in FTD (n = 52) and contrasted against a dementia control Alzheimer disease (AD) group (n = 20) and healthy age-matched controls (n = 18).
  
  
  RESULTS
  Both patient groups had similar ADL scores. However, FTD and AD differed on the gray matter atrophy areas associated with ADL scores. The FTD showed involvement of prefrontal and thalamus regions while AD showed widespread temporal, parietal, frontal, and caudate atrophy correlating with ADL dysfunction. Importantly, only the left superior frontal gyrus was implicated in ADL dysfunction for both FTD and AD.
  
  
  CONCLUSIONS
  Differences in underlying neural correlates of ADL impairment have important clinical implications as these differences should be taken into account when interventions are planned. Dementia subtypes might require specifically tailored interventions for functional disability.
authors: Neuroscience Research Australia, Sydney, Australia.
authors: E
authors: E
authors: Mioshi
authors: J R
authors: JR
authors: Hodges
authors: M
authors: M
authors: Hornberger
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000523:psychology; D001284:Atrophy; D001519:Behavior; D001921:Brain / Q000473:pathology; D003071:Cognition / Q000502:physiology; D056324:Diffusion Tensor Imaging; D004522:Educational Status; D005260:Female; D057180:Frontotemporal Dementia / Q000473:pathology* / Q000523:psychology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests