title: The interrelationship between non-motor symptoms in Atypical Parkinsonism.
abstract: BACKGROUND
  Atypical Parkinsonism is less common and has more severe symptoms than Parkinson's disease (PD). Little is known about the non-motor symptom (NMS) characteristics of multiple systemic atrophy (MSA) or progressive supranuclear palsy (PSP). We report the interrelationship of NMS in MSA, PSP, and PD.
  
  
  METHODS
  We studied 117 cases of PD and 57 of Atypical Parkinsonism. Out of the 57 patients, 31 had multiple systemic atrophy parkinsonian subtype (MSA-P), 14 had multiple systemic atrophy cerebellar dysfunction subtype (MSA-C), and 12 had PSP. We assessed the condition of the patients using the United Parkinson's Disease Rating Scale part III (UPDRS-III), the modified Hoehn & Yahr scale (H&Y), the non-motor symptom scale (NMSS), and the Parkinson's Disease Questionnaire (PDQ-39).
  
  
  RESULTS
  In Atypical Parkinsonism, the NMSS scores significantly correlated with PDQ-39 scores, but not with UPDRS-III. In the MSA-P group, the mood/cognitive domain significantly correlated with both the urinary and sleep/fatigue domains. In the MSA-C group, the sleep/fatigue domain correlated with the mood/cognition and cardiovascular domains. Finally, in the PSP and PD groups, the attention/memory domain significantly correlated with the sleep/fatigue and mood/cognition domains.
  
  
  CONCLUSIONS
  These results suggest that, with respect to cognitive function, dysautonomia and sleep/fatigue are detrimental factors in MSA and PSP, respectively.
authors: Department of Neurology, Korea University College of Medicine, Seoul, Republic of Korea.
authors: Chan-Nyoung
authors: CN
authors: Lee
authors: Minjik
authors: M
authors: Kim
authors: Hye Mi
authors: HM
authors: Lee
authors: Ji-Wan
authors: JW
authors: Jang
authors: Seon-Min
authors: SM
authors: Lee
authors: Do-Young
authors: DY
authors: Kwon
authors: Kun-Woo
authors: KW
authors: Park
authors: Seong-Beom
authors: SB
authors: Koh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D010300:Parkinson Disease / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology