title: Synthesis of fully substituted pyrimidines.
abstract: A novel approach to the synthesis of fully substituted pyrimidine derivatives armed with an oxy-functionalized acetate chain at the ring is described. The manifold uses amidines as the nitrogen source and activated skipped diynes as the electrophilic reactive partners in a coupled domino strategy. In the first domino reaction, two consecutive aza-Michael additions assemble the six-membered ring heterocycle, while in the second domino process, a [H]-shift and a [3,3]-sigmatropic rearrangement lead to the aromatization of the product.
authors: Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Astrofísico Francisco Sánchez 3, 38206, La Laguna, Tenerife, Spain. dtejedor@ipna.csic.es
authors: David
authors: D
authors: Tejedor
authors: Sara
authors: S
authors: López-Tosco
authors: Fernando
authors: F
authors: García-Tellado
mesh_terms: D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011743:Pyrimidines