title: Effect of tonifying liver and kidney-essence herbs on expression of Nogo-A and p75(NTR) in cerebral ischemic stroke rats model.
abstract: OBJECTIVE
  To observe the effect of tonifying liver and kidney-essence herbs on expression of a nerve regeneration inhibitor, Nogo for neuron A (Nogo-A), and its associated signaling molecule, low-affinity neurotrophin receptor p75 (p75(NTR)), in rats with cerebral ischemic stroke (CIS), with the aim of exploring the possible mechanism of tonifying liver and kidney-essence herbs in recovery following injury to the central nervous system.
  
  
  METHODS
  A cerebral ischemic stroke model in SD rats was established with the suture-occlusion method. Successful model rats were divided into placebo and herb groups at random; sham-operated and control groups were set up simultaneously. Each of these groups was divided into six subgroups at random. Expression of Nogo-A and p75(NTR) was evaluated with immunofluorescence microscopy at days 3, and weeks 1, 2, 3, 4 and 8 after administration.
  
  
  RESULTS
  Tonifying liver and kidney-essence herbs suppressed the expression of Nogo-A and p75(NTR) (P < 0.05 and P < 0.01, respectively).
  
  
  CONCLUSIONS
  Suppressing the expression of Nogo-A and p75(NTR) is possibly one of the mechanisms underlying the ability of tonifying liver and kidney-essence herbs to promote recovery of the injured central nervous system.
authors: Department of Encephalopathy, Shaanxi University of Traditional Medicine Hospital, Shaanxi 712000, China.
authors: Yongmei
authors: Y
authors: Yan
authors: Tianhao
authors: T
authors: Li
authors: Li
authors: L
authors: Liu
authors: Haizhe
authors: H
authors: Zhou
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D008297:Male; D009185:Myelin Proteins / Q000235:genetics* / Q000378:metabolism; D000070798:Nogo Proteins; D051381:Rats; D017207:Rats, Sprague-Dawley; D020800:Receptor, Nerve Growth Factor / Q000235:genetics* / Q000378:metabolism; D020521:Stroke / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human; D020800:Receptor, Nerve Growth Factor; C000603197:Rtn4 protein, rat