title: Antithymocyte globulin/antilymphocyte globulin plus kidney-nourishing Chinese medicinal: effect on severe aplastic anemia.
abstract: OBJECTIVE
  To explore the effect of antithymocyte globulin (ATG)/antilymphocyte globulin (ALG) plus kidney-nourishing Chinese medicinal (KNCM) on severe aplastic anemia (SAA).
  
  
  METHODS
  Twenty-five subjects of severe aplastic anemia were treated with ATG/ALD plus KNCM between 1992 and 2009, and the clinical data before and after treatment were collected and analyzed.
  
  
  RESULTS
  Of the 25 patients, 9 were nearly cured, 6 were improved, 5 were in remission, and 5 failed. The overall effective rate was 80.0%. The 3-year, 5-year, 10-year, 15-year survival rate were respectively 98.6%, 97.3%, 97.3%, 67.5%, and median survival time was 180 months. Compared to the conditions before administering the medication of ATG/ ALG plus KNCM, after 2 weeks, reticulocyte was first improved (P = 0.001); one month later, followed by palette (P = 0.037); two months later, by neutrophil cell in peripheral blood (P = 0.001); three months later, then by the hemoglobin (P = 0.012). By conducting 1-year follow-up, 1 case of complication--paroxysmal nocturnal hemoglobinuria (PNH) was identified and the patient still alive today.
  
  
  CONCLUSIONS
  ATG/ALG plus KNCM had better effect on SAA and could improve patients' survival rate.
authors: Department of Hematology, Xi Yuan Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors: Xudong
authors: X
authors: Tang
authors: Feng
authors: F
authors: Liu
authors: Liu
authors: L
authors: Li
authors: Chi
authors: C
authors: Liu
authors: Shanshan
authors: S
authors: Zhang
authors: Haiyan
authors: H
authors: Xiao
authors: Chunmei
authors: C
authors: Zheng
authors: Shu
authors: S
authors: Xu
authors: Rou
authors: R
authors: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000188:drug therapy* / Q000401:mortality; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D002648:Child; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000961:Antilymphocyte Serum; D004365:Drugs, Chinese Herbal