title: Hypohidrosis and hyperthermia during topiramate treatment in children.
abstract: Topiramate is one of the newer generation antiepileptic drugs with a beneficial clinical effect on various seizure types. In this study, we present the clinical findings of hypohidrosis and hyperthermia with topiramate in pediatric patients. The data were collected retrospectively on 173 patients diagnosed as epilepsy on topiramate treatment, and hypohidrosis-related symptoms induced by topiramate were found in 22 patients. Their mean age was 64.45 +/- 56.63 months. The mean duration of topiramate treatment was 7.09 +/- 2.46 months, and the mean dose was 5.37 +/- 1.75 mg/kg/day. All of the patients complained of hypohidrosis and hyperthermia. Six (27.2%) of them had facial flushing, 4 (18.1%) had heat sensation and only 1 (4.5%) had lethargy. Hypohidrosis-related symptoms resolved after discontinuation of the medication. In conclusion, children treated with topiramate should be cautioned regarding these potential adverse effects and advised to avoid its use during the hot summer season.
authors: Department of Pediatric Neurology, Cukurova University Faculty of Medicine, Adana, Turkey. fincecik@yahoo.com
authors: Faruk
authors: F
authors: Incecik
authors: M Ozlem
authors: MO
authors: Hergüner
authors: Sakir
authors: S
authors: Altunbaşak
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000453:epidemiology; D005500:Follow-Up Studies; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007007:Hypohidrosis / Q000139:chemically induced* / Q000453:epidemiology; D015994:Incidence; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures / Q000188:drug therapy*; D000077236:Topiramate; D014421:Turkey / Q000453:epidemiology
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose