title: Evaluation of the clinical features of HCC following hepatectomy for different stages of HCC.
abstract: OBJECTIVE
  This study was to evaluate and compare the clinical and pathological characteristics and patient outcomes after hepatic resection for different stages of HCC according to the Barcelona Clinic Liver Cancer (BCLC) classification system.
  
  
  METHODS
  Three hundred and sixteen primary hepatectomies for HCC were divided into stage 0-c, according to BCLC classification. The clinicopathological variables of the patients in each group were compared statistically.
  
  
  RESULTS
  There were significant differences in the incidence of capsular invasion, α-fetoprotein, blood loss, blood transfusion and tumor related number among each of the stage 0-C, respectively (p<0.05). Disease-free survival was influenced by histopathological grade (p=0.000), tumor capsule (p=0.015), tumor related number (p=0.000) and BCLC (p=0.000). Overall survival was influenced by histopathological grade (p=0.000), tumor capsule (p=0.035), tumor related number (p=0.005), cirrhosis (p=0.000) and BCLC (p=0.000).
  
  
  CONCLUSIONS
  HCC in stage 0 and A were closely correlated with a better prognosis, which reflected the relatively benign pathobiological features of HCC at an early developmental stage. In comparison, HCC in stages B and C exhibited a tendency towards a more aggressive phenotype. Our findings suggest that stage B classification is optimal for estimating the biological behavior and clinical prognosis of patients undergoing partial hepatectomy for early stage HCC.
authors: The First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China.
authors: Chuang
authors: C
authors: Ma
authors: Minhui
authors: M
authors: Chi
authors: Hongying
authors: H
authors: Su
authors: Xinchun
authors: X
authors: Cheng
authors: Lihong
authors: L
authors: Chen
authors: Yuhua
authors: Y
authors: Kan
authors: Wei
authors: W
authors: Wei
authors: Xinhui
authors: X
authors: Huang
authors: Yuntong
authors: Y
authors: Li
authors: Ling
authors: L
authors: Li
authors: Kecan
authors: K
authors: Lin
authors: Yao
authors: Y
authors: Huang
authors: Yanbin
authors: Y
authors: Wu
authors: Xiongfei
authors: X
authors: Huang
authors: Aimin
authors: A
authors: Huang
authors: Jingfeng
authors: J
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001803:Blood Transfusion; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: C097353:AFP protein, human; D000509:alpha-Fetoproteins