title: Compromised NK cell-mediated antibody-dependent cellular cytotoxicity in chronic SIV/SHIV infection.
abstract: Increasing evidence indicates that antibody-dependent cellular cytotoxicity (ADCC) contributes to the control of HIV/SIV infection. However, little is known about the ADCC function of natural killer (NK) cells in non-human primate model. Here we demonstrated that ADCC function of NK cells was significantly compromised in chronic SIV/SHIV infection, correlating closely with the expression of FcγRIIIa receptor (CD16) on NK cells. CD32, another class of IgG Fc receptors, was identified on NK cells with higher expression in the infected macaques and the blockade of CD32 impacted the ability of NK cells to respond to antibody-coated target cells. The inhibition of matrix metalloproteases (MMPs), a group of enzymes normally involved in tissue/receptor remodeling, could restore NK cell-mediated ADCC with increased CD16 expression on macaque NK cells. These data offer a clearer understanding of NK cell-mediated ADCC in rhesus macaques, which will allow us to evaluate the ADCC repertoire arising from preclinical vaccination studies in non-human primates and inform us in the future design of effective HIV vaccination strategies.
authors: Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
authors: Xuan
authors: X
authors: He
authors: Dan
authors: D
authors: Li
authors: Zhenwu
authors: Z
authors: Luo
authors: Hua
authors: H
authors: Liang
authors: Hong
authors: H
authors: Peng
authors: Yangyang
authors: Y
authors: Zhao
authors: Nidan
authors: N
authors: Wang
authors: Donghua
authors: D
authors: Liu
authors: Chuan
authors: C
authors: Qin
authors: Qiang
authors: Q
authors: Wei
authors: Huimin
authors: H
authors: Yan
authors: Yiming
authors: Y
authors: Shao
mesh_terms: D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects / Q000276:immunology*; D045744:Cell Line, Tumor; D002908:Chronic Disease; D005786:Gene Expression Regulation / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008253:Macaca mulatta; D061965:Matrix Metalloproteinase Inhibitors / Q000494:pharmacology; D020782:Matrix Metalloproteinases / Q000378:metabolism; D051379:Mice; D017452:Receptors, IgG / Q000378:metabolism; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000502:physiology*
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D017452:Receptors, IgG; D020782:Matrix Metalloproteinases