title: Differential immunological responses induced by infection with female muscle larvae and newborn larvae of Trichinella pseudospiralis.
abstract: Trichinella pseudospiralis infection can modulate the immunological response of autoimmune and allergic diseases leading to the amelioration of these diseases. The present study was undertaken to compare immunity induced by adult worms and muscle larvae. Higher eosinophilia was observed from newborn larva (NBL) infection than from adult females while higher levels of IgE were observed in adult female infections over those induced by NBL. The IgG1 response to ES antigen was more prominent in infections with adult females. The IgG2 responses to larval crude antigen were prominent against NBL. The Th2 cytokine, IL-4 cytokine was elevated in adult female infection following re-stimulation with adult crude antigen and ES. Both infections induced strong IFN-γ responses. The present study demonstrates that adult female worms induced stronger Th2 responses (IgG1, IgE and IL-4 responses) than NBL. Further examination of the mechanisms involved in immune modulation may be helpful for identifying Trichinella-derived molecules responsible for regulating autoimmune and allergic diseases.
authors: Department of Parasitology, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu 501-1194, Japan. wu@gifu-u.ac.jp
authors: Z
authors: Z
authors: Wu
authors: I
authors: I
authors: Nagano
authors: K
authors: K
authors: Asano
authors: M Y
authors: MY
authors: Liu
authors: Y
authors: Y
authors: Takahashi
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism*; D004802:Eosinophilia / Q000276:immunology; D005260:Female; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007371:Interferon-gamma / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D007814:Larva; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000469:parasitology; D014234:Trichinella / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D016207:Cytokines; D007074:Immunoglobulin G; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma