title: The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults.
abstract: We explored the associations of the CD4/CD8 ratio with markers of immunoactivation, immunosenescence and T-cell subsets, in 37 vertically HIV-infected children and adolescents. CD4/CD8 ratio inversion was associated with higher frequencies of activated, senescent and activated/exhausted CD4+ and CD8+ T-cells, and a skewed T-cell phenotype from naive toward effector memory which persisted after the multivariate analysis. Thus, the CD4/CD8 ratio may identify patients with higher immunoactivation despite ART.
authors: Laboratorio de InmunoBiología Molecular y Servicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Talía
authors: T
authors: Sainz
authors: Sergio
authors: S
authors: Serrano-Villar
authors: Laura
authors: L
authors: Díaz
authors: María Isabel
authors: MI
authors: González Tomé
authors: María Dolores
authors: MD
authors: Gurbindo
authors: María Isabel
authors: MI
authors: de José
authors: María José
authors: MJ
authors: Mellado
authors: José T
authors: JT
authors: Ramos
authors: Javier
authors: J
authors: Zamora
authors: Santiago
authors: S
authors: Moreno
authors: María Angeles
authors: MA
authors: Muñoz-Fernández
mesh_terms: D000293:Adolescent; D000375:Aging / Q000276:immunology; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D015415:Biomarkers; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016922:Cellular Senescence / Q000276:immunology*; D002648:Child; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000635:transmission; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008213:Lymphocyte Activation / Q000276:immunology*; D012044:Regression Analysis; D019562:Viral Load / Q000276:immunology; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D015415:Biomarkers