title: Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method.
abstract: Microwave-assisted Fmoc solid phase peptide synthesis (SPPS) was applied in combination with the isopeptide strategy to establish a new method for the rapid synthesis of difficult sequence-containing peptide. A model peptide (8Q(Ser)) was produced in one day using the method developed, in contrast with two weeks using the isopeptide method. Both methods produced the desired peptide in high yield and purity, while classical SPPS did not result in the desired product.
authors: The University of Queensland, School of Chemistry and Molecular Biosciences, Brisbane, QLD 4072, Australia.
authors: Waleed M
authors: WM
authors: Hussein
authors: Tzu-Yu
authors: TY
authors: Liu
authors: Istvan
authors: I
authors: Toth
authors: Mariusz
authors: M
authors: Skwarczynski
mesh_terms: D002851:Chromatography, High Pressure Liquid; D008872:Microwaves; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis*; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*
chemical_list: D010455:Peptides