title: The association of IL-6 and IL-6R gene polymorphisms with chronic periodontitis in a Chinese population.
abstract: OBJECTIVE
  The aim of our investigation is to reveal the association of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) gene polymorphisms with chronic periodontitis in Northwestern Chinese Han Population.
  
  
  METHODS
  A case-control study of 199 cases of chronic periodontitis patients and 216 healthy controls was performed. Genomic DNA was isolated from whole venous blood, and four single nucleotide polymorphisms (IL-6 -572 G/C and -1363 G/T, IL-6R -183 G/A and +48892 A/C) were analysed using polymerase chain reaction, followed by restriction fragment length polymorphism analysis and sequencing methods.
  
  
  RESULTS
  Our SNP analyses showed that the distribution of the IL-6 -572 G/C and IL-6R -183 G/A polymorphisms did not differ between patients and controls. The frequency of the IL-6 -1363 G/T genotype GG was significantly increased chronic periodontitis cases (P = 0.023, odds ratio (OR) = 2.825 adjusted for gender and age.) The IL-6R +48892 A/C polymorphisms genotype CC was found to be protective against chronic periodontitis (P = 0.004, OR = 0.318 adjusted for gender and age.). In addition, compared with the other haplotypes, haplotype A(+48892) A(-183) was significantly associated with chronic periodontitis, with an odds ratio of 0.720 (P = 0.0235).
  
  
  CONCLUSIONS
  Our results suggest that the IL-6 -1363 G/T and IL-6R +48892 A/C polymorphisms may contribute to genetic susceptibility to chronic periodontitis in Northwestern Chinese Han population.
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, Lanzhou University, Lanzhou City, Gansu Province, China; Institute of Hematology, Lanzhou General Hospital of PLA, Lanzhou, China.
authors: H-Y
authors: HY
authors: Zhang
authors: L
authors: L
authors: Feng
authors: H
authors: H
authors: Wu
authors: X-D
authors: XD
authors: Xie
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D019947:Receptors, Interleukin-6 / Q000235:genetics*
chemical_list: D015850:Interleukin-6; D019947:Receptors, Interleukin-6
keywords: chronic periodontitis; genetic polymorphism; interleukin-6; interleukin-6 receptor