title: A preliminary study of the effects of ulinastatin on early postoperative cognition function in patients undergoing abdominal surgery.
abstract: OBJECTIVE
  Ulinastatin, a urinary trypsin inhibitor, is widely used to treat acute systemic inflammatory disorders. However, its effects on early postoperative cognitive function have not been fully elucidated. The objective of this study was to investigate the effect of ulinastatin on serum IL-6, TNF-α, CRP and S100β protein concentration and early postoperative cognitive function in patients after abdominal surgery.
  
  
  METHODS
  Eighty ASAI-II patients older than 65 years, scheduled for elective abdominal surgery were randomly divided into 2 groups (n=40 each): ulinastatin and control. After induction of anesthesia, the ulinastatin group received 10,000units/kg of ulinastatin intravenously before surgical incision and 5000units/kg on post-op days 1-3. Cognitive function was assessed preoperatively and on post-op day 7 using a battery of nine neuropsychological tests. Serum IL-6, TNF-α, CRP and S100β protein levels were determined preoperatively, at the end of surgery and on post-op days 1-3.
  
  
  RESULTS
  There were significant decrements in each neuropsychological test, except for the Digit Span Backward Test between groups. Based on neuropsychological testing, the ulinastatin group had a lower incidence of postoperative cognitive dysfunction (POCD) than the control group (2.5% versus 27.5%, p<0.05). In the control group, serum S100β protein and IL-6 concentrations increased at the end of surgery and on post-op days 1 and 2. The ulinastatin group had lower serum S100β protein and IL-6 concentrations than those in the control group (p<0.05).
  
  
  CONCLUSIONS
  Ulinastatin may be effective in reducing the incidence of early postoperative cognitive dysfunction.
authors: Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
authors: Xu
authors: X
authors: Lili
authors: Hu
authors: H
authors: Zhiyong
authors: Shen
authors: S
authors: Jianjun
mesh_terms: D034841:Abdominal Cavity / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D003072:Cognition Disorders / Q000378:metabolism / Q000523:psychology*; D004311:Double-Blind Method; D005260:Female; D006023:Glycoproteins / Q000627:therapeutic use*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood; D011183:Postoperative Complications / Q000378:metabolism / Q000523:psychology*; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use*; D013514:Surgical Procedures, Operative; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D006023:Glycoproteins; D015850:Interleukin-6; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D015842:Serine Proteinase Inhibitors; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; C028665:urinastatin