title: Long-term multicentre randomised controlled study of high frequency chest wall oscillation versus positive expiratory pressure mask in cystic fibrosis.
abstract: BACKGROUND
  Positive expiratory pressure (PEP) is the most commonly used method of airway clearance (AC) in Canada for patients with cystic fibrosis (CF) whereas, in some countries, high frequency chest wall oscillation (HFCWO) is the preferred form of AC. There have been no long-term studies comparing the efficacy of HFCWO and PEP in the CF population.
  
  
  OBJECTIVE
  To determine the long-term efficacy of HFCWO compared with PEP mask therapy in the treatment of CF as measured by the number of pulmonary exacerbations (PEs).
  
  
  METHODS
  A randomised controlled study was performed in 12 CF centres in Canada. After a 2-month washout period, subjects were randomised to perform either HFCWO or PEP mask therapy for 1 year.
  
  
  RESULTS
  107 subjects were enrolled in the study; 51 were randomised to PEP and 56 to HFCWO. There were 19 dropouts within the study period, of which 16 occurred prior to or at the time of randomisation. There were significant differences between the groups in the mean number of PEs (1.14 for PEP vs 2.0 for HFCWO) and time to first PE (220 days for PEP vs 115 days for HFCWO, p=0.02). There was no significant difference in lung function, health-related quality of life scores or patient satisfaction scores between the two groups. PEP mask therapy required a shorter treatment time.
  
  
  CONCLUSIONS
  The results of this study favour PEP and do not support the use of HFCWO as the primary form of AC in patients with CF.
  
  
  BACKGROUND
  NCT00817180.
authors: Division of Paediatric Respirology and Department of Physiotherapy, Cystic Fibrosis Clinic, BC Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada. mmcilwaine@cw.bc.ca
authors: Maggie Patricia
authors: MP
authors: McIlwaine
authors: Nancy
authors: N
authors: Alarie
authors: George F
authors: GF
authors: Davidson
authors: Larry C
authors: LC
authors: Lands
authors: Felix
authors: F
authors: Ratjen
authors: Ruth
authors: R
authors: Milner
authors: Blythe
authors: B
authors: Owen
authors: Jennifer L
authors: JL
authors: Agnew
mesh_terms: D000293:Adolescent; D000328:Adult; D035641:Chest Wall Oscillation / Q000379:methods*; D002648:Child; D003550:Cystic Fibrosis / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D017214:Laryngeal Masks; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration / Q000295:instrumentation*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Cystic Fibrosis; Health Economist