title: Advantages of isolated application of fibrin glue over suture in preservation of second-grade spleen lesion.
abstract: OBJECTIVE
  The aim of this procedure was to assess the safety and efficiency of glue application in the treatment of lienal second-degree lesions, compared with traditional suture method of treatment.
  
  
  BACKGROUND
  The spleen is the most frequently injured intra-abdominal structure regardless of injury mechanisms. Fibrin glue is a useful bio-adhesive for safe and efficient treatment of diffuse parenchymatous spleen haemorrhages.
  
  
  METHODS
  Seventy dogs under intravenous anaesthesia were subdued to spleen incision in length of 5 cm and depth of 2 cm. Forty animals from the experimental group were treated with fibrin glue preservation, and 30 animals from the control group were treated with suture. Removed spleens were histologically analyzed. No animal was sacrificed.
  
  
  RESULTS
  The application of fibrin glue allowed reparation to be accomplished in all cases. The effectiveness of primary repair was registered in 95 %, with only 5 % of cases requiring an application of fibrin omentoplasty. Secondary bleeding was registered only in 1 (2.5 %) case. Preservation with suture is primarily effective only in 40 %, requires additional repair in 23 %, and even 37 % of cases are not feasible. This method is characterized by mortality of 21 %, secondary haemorrhage (32 %), appearance of focal necrosis (42 %) and abscess (11 %).
  
  
  CONCLUSIONS
  Application of FG is a method of choice in cases of second-degree transcapsular spleen lesions and it has a considerable advantage over suture (Tab. 4, Fig. 6, Ref. 24).
authors: Medical FAculty of Nis, Serbia. milan.m.jovanovic@gmail.com
authors: M
authors: M
authors: Jovanovic
authors: N
authors: N
authors: Djordjevic
authors: P
authors: P
authors: Djordjevic
authors: Z
authors: Z
authors: Damnjanovic
authors: I
authors: I
authors: Smiljkovic
authors: M
authors: M
authors: Radojkovic
mesh_terms: D000818:Animals; D004285:Dogs; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D013154:Spleen / Q000601:surgery*; D013537:Sutures; D014014:Tissue Adhesives / Q000008:administration & dosage*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives