title: Augmenting pancreatic anastomosis during whipple operation with fibrin glue: a beneficial technical modification?
abstract: BACKGROUND
  Various techniques have been described to try and reduce the rate of anastomotic leak following pancreaticoduodenectomy, which remains a challenge for pancreatic surgeons worldwide. We outline a technique to reinforce the pancreatic anastomosis with a double layer of fibrin glue between suture lines.
  
  
  METHODS
  Our technique for pancreatic anastomosis is described in detail. A review of consecutive pancreaticoduodenectomies by a single surgeon (NAC) since introduction of fibrin glue anastomosis reinforcement was compared with a historical control cohort performed by the same surgeon.
  
  
  RESULTS
  Thirty-two consecutive pancreaticoduodenectomies were undertaken between March 2008 and March 2012 by a single surgeon, 30 patients had fibrin glue augmentation of the pancreatico-gastrostomy anastomosis. Median length of stay was 12 days. There were no pancreatic leaks or mortality since adopting fibrin glue for the pancreatic anastomosis; however; this single surgeon series is not large enough to provide statistical evidence of a difference since glue was adopted.
  
  
  CONCLUSIONS
  Our results since the incorporation of this step in pancreaticoduodenectomy are encouraging. Selective use of glue is worthy of consideration in difficult cases, although confirmation of a reduction in pancreatic leak rate is not yet established, and we advocate a multi-institution randomized controlled trial to explore this.
authors: Epworth Freemasons Hospital, Melbourne, Victoria, Australia.
authors: Paul J
authors: PJ
authors: Conaglen
authors: Neil A
authors: NA
authors: Collier
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D057868:Anastomotic Leak / Q000517:prevention & control*; D015718:Fibrin Tissue Adhesive; D006801:Humans; D010179:Pancreas / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000379:methods*; D012189:Retrospective Studies; D013270:Stomach / Q000601:surgery*; D014014:Tissue Adhesives; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives
keywords: anastomosis; fibrin tissue adhesive; pancreas; pancreatic fistula; pancreaticoduodenectomy; surgical