title: Clinical predictors of drug response in patients with obsessive-compulsive disorder.
abstract: OBJECTIVE
  The aim of this study was to evaluate which clinical variables might influence the antiobsessional responses to proserotonergic drugs in a sample of patients with obsessive-compulsive disorder (OCD).
  
  
  METHODS
  Two hundred forty-nine patients with DSM-IV OCD under-gone mean 13-month treatments with selective serotonin reuptake inhibitors. According to the treatment response, defined as a reductions of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score ≥35%, patients were divided into two groups.
  
  
  RESULTS
  One hundred fourteen patients responded to the treatment and the other one hundred thirty five patients did not. Responders had a significant long duration of medication in YUMC OCD clinic, short total duration of past treatment in other institutes, and higher frequency of drug naïve cases and lower baseline Y-BOCS scores.
  
  
  CONCLUSIONS
  The pre-treatment factors including total duration of past treatment, drug naïve or not, baseline OCD symptoms and the factor of duration of the treatment may influence drug treatment response in OCD patients.
authors: Department of Psychiatry, Severance Mental Health Hospital, Yonsei University, Gwangju, Korea.
authors: Chan-Hyung
authors: CH
authors: Kim
authors: Jae-Wook
authors: JW
authors: Jeong
authors: Eun Ju
authors: EJ
authors: Kim
authors: Yoon Shick
authors: YS
authors: Shin
authors: Ho Suk
authors: HS
authors: Suh
authors: Hong Shick
authors: HS
authors: Lee
authors: Min-Seong
authors: MS
authors: Koo
keywords: Clinical predictors; Drug response; Obsessive-compulsive disorder; Treatment duration