title: Japanese growth prediction model for prepubertal children with growth hormone deficiency.
abstract: BACKGROUND
  Individual responses to growth hormone (GH) treatment are variable, and efficacy should be judged in each individual patient.
  
  
  OBJECTIVE
  The aim of this study was to develop a prediction model for the growth response of GH treatment in Japanese prepubertal children with GH deficiency.
  
  
  METHODS
  Pediatric patients with GH deficiency were enrolled. Auxological measurements, markers of GH status, and markers of bone metabolism were measured at baseline and at 3 and 6 months after the start of GH treatment. Correlations with height velocity (HV) at 36 months of GH treatment were calculated. Prediction models were evaluated by multiple regression analysis.
  
  
  RESULTS
  The model, which combined the parameters of HV at 3 months, insulin-like growth factor-binding protein 3, standard deviation score, and pyridinoline at 3 months, best predicted HV at 36 months.
  
  
  CONCLUSIONS
  This model can accurately predict the first 3 years of growth response after 3 months of GH replacement therapy in prepubertal Japanese children.
authors: Osaka Health Science University, Fukushima-ku, Osaka, Japan. yoseino@okn.gr.jp
authors: Yoshiki
authors: Y
authors: Seino
authors: Sumie
authors: S
authors: Yamashita
authors: Yoji
authors: Y
authors: Morisaki
authors: Hiroyuki
authors: H
authors: Tanaka
authors: Kazuo
authors: K
authors: Chihara
authors: Toshiaki
authors: T
authors: Tanaka
mesh_terms: D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007564:Japan; D008297:Male; D008954:Models, Biological; D011627:Puberty; D012044:Regression Analysis
chemical_list: D019382:Human Growth Hormone