title: Novel microbial transformation of desacetylcinobufagin by Fusarium avenaceum AS 3.4594.
abstract: In this paper, the microbial transformation of desacetylcinobufagin (1) by Fusarium avenaceum AS 3.4594 was investigated, and four metabolites were isolated and characterized as 3-keton-desacetylcinobufagin (2), 3-epi-desacetylcinobufagin (3), bufadienolide A (4), and 15β,16α-dihydroxyl-17βH-bufalin (5), respectively. Among them, 4 and 5 are new compounds. The cytotoxicities of transformed products (2-5) against Hela cells were also investigated.
authors: The First Affiliated Hospital of Liaoning Medical University, Jinzhou 120001, China.
authors: Zhi-Tu
authors: ZT
authors: Zhu
authors: Sha
authors: S
authors: Den
authors: Yan
authors: Y
authors: Wang
authors: Yan-Yan
authors: YY
authors: Zhao
authors: Li
authors: L
authors: Wang
authors: Hui-Rang
authors: HR
authors: Chen
authors: Dan
authors: D
authors: Liu
mesh_terms: D001711:Biotransformation; D002018:Bufanolides / Q000737:chemistry / Q000302:isolation & purification*; D005670:Fusarium / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D002018:Bufanolides; C582494:desacetylcinobufagin