title: Salivary flow, testosterone, and femur bone mineral density in menopausal women with oral dryness feeling.
abstract: OBJECTIVE
  We compared salivary flow, serum and saliva testosterone, and femur bone mineral density (BMD) of menopausal women with or without xerostomia.
  
  
  METHODS
  A case/control study was performed on 60 selected menopausal women with or without xerostomia. BMD and testosterone concentration were measured by a dual-energy x-ray absorptiometry system and enzyme-linked immunosorbent assay method, respectively.
  
  
  RESULTS
  Multinomial logistic regression demonstrated that low saliva flow rate (odds ratio [OR] = 22.8, 95% confidence interval [CI]: 5.4, 96.8), low femur BMD (OR = 6.0, CI: 1.8, 20.0), high stimulated saliva testosterone (OR = 5.2, CI: 2.0, 18.9), high unstimulated saliva testosterone (OR = 3.8, 95% CI: 1.6, 12.3), and high serum testosterone (OR = 2.7, CI: 1.1, 7.2) were associated with an increased risk of xerostomia in menopausal women.
  
  
  CONCLUSIONS
  High serum and salivary testosterone and low femur BMD and saliva flow were associated with xerostomia. Of these factors, low salivary flow seems to be the most important element in the perception of dry mouth.
authors: Department of Oral Medicine, Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. aghahose@sina.tums.ac.ir
authors: Farzaneh
authors: F
authors: Agha-Hosseini
authors: Mahdieh-Sadat
authors: MS
authors: Moosavi
authors: Iraj
authors: I
authors: Mirzaii-Dizgah
mesh_terms: D015502:Absorptiometry, Photon; D015519:Bone Density / Q000502:physiology*; D016022:Case-Control Studies; D003679:Deglutition / Q000502:physiology; D004326:Drinking / Q000502:physiology; D005260:Female; D005272:Femur Neck / Q000033:anatomy & histology*; D006801:Humans; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D012636:Secretory Rate / Q000502:physiology; D013739:Testosterone / Q000032:analysis / Q000097:blood*; D013894:Thirst / Q000502:physiology; D014987:Xerostomia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D013739:Testosterone