title: Abdominal adiposity is associated with fatty acid desaturase activity in boys: implications for C-reactive protein and insulin resistance.
abstract: Fatty acid composition, which is altered in patients with abdominal obesity, is influenced not only by dietary intake but also by the desaturating enzymes stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). We investigated desaturase activities and their associations with metabolic risk factors, C-reactive protein levels (CRP) and insulin resistance in Japanese children. There were 237 school children in this study; 115 were boys. The fatty acid composition of plasma phospholipids was analyzed, and the following desaturase activities were estimated: SCD (16:1n-7/16:0 and 18:1n-9/18:0), D6D (20:3n-6/18:2n-6) and D5D (20:4n-6/20:3n-6). D6D and D5D activities, but not SCD activity, were significantly associated with triglyceride levels, high-density lipoprotein cholesterol levels and insulin resistance in both sexes, and with CRP levels in boys. In addition, increased abdominal adiposity was significantly associated with increased D6D activity, and decreased D5D activity and insulin resistance in both sexes, and with increased CRP levels in boys. The n-6 polyunsaturated fatty acid desaturation pathway may be associated with metabolic risk factors, insulin resistance and increased inflammation in children with abdominal obesity, especially in boys.
authors: Department of Pediatrics and Child Health, Nihon University School of Medicine 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo173-8610, Japan.
authors: Emiko
authors: E
authors: Saito
authors: Tomoo
authors: T
authors: Okada
authors: Yuriko
authors: Y
authors: Abe
authors: Minako
authors: M
authors: Odaka
authors: Yuki
authors: Y
authors: Kuromori
authors: Fujihiko
authors: F
authors: Iwata
authors: Mitsuhiko
authors: M
authors: Hara
authors: Hideo
authors: H
authors: Mugishima
authors: Yohei
authors: Y
authors: Kitamura
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000293:Adolescent; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D050602:Linoleoyl-CoA Desaturase / Q000378:metabolism*; D008297:Male; D056128:Obesity, Abdominal / Q000201:enzymology* / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; D002097:C-Reactive Protein; D044943:Fatty Acid Desaturases; D050602:Linoleoyl-CoA Desaturase