title: New preparation of TMPZnCl·LiCl by Zn insertion into TMPCl. Application to the functionalization of dibromodiazines.
abstract: A practical zinc insertion starting from cheap commercial zinc powder and TMPCl (1-chloro-2,2,6,6-tetramethylpiperidine) allows a fast and efficient synthesis of the zinc base TMPZnCl·LiCl under mild conditions in high yields. This base is kinetically highly active and was used for the regio- and chemoselective functionalization of dibromodiazines (pyridazines and pyrazines).
authors: Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany.
authors: Andreas
authors: A
authors: Unsinn
authors: Mark J
authors: MJ
authors: Ford
authors: Paul
authors: P
authors: Knochel
mesh_terms: D020650:Combinatorial Chemistry Techniques; D006843:Hydrocarbons, Chlorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010880:Piperidines / Q000737:chemistry*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: C581650:1-chloro-2,2,6,6-tetramethylpiperidine; D006843:Hydrocarbons, Chlorinated; D009942:Organometallic Compounds; D010880:Piperidines; D011724:Pyridazines; D008094:Lithium; D015032:Zinc