title: Lifetime exposure to low doses of lead in rats: effect on selected parameters of carbohydrate metabolism.
abstract: The aim of the study was to assess the effects of exposure to low doses of lead dissolved in drinking water (average daily dose of 2.2 mg kg(-1) day(-1)) on selected carbohydrate metabolism parameters in 20 wistar rats. Animals were divided into two groups - control (C) (group drinking clear water) and experimental group (Pb; group exposed to low doses of lead acetate in a concentration of 100 μmol l(-1) of drinking water). In this study, we studied the biochemical parameters (glucose, haemoglobin (Hb), glycated haemoglobin (HbA1c), lactate dehydrogenase (LDH) and amylase (AMS)) in rat blood. Glucose and Hb concentration and AMS activity decreased, LDH activity increased but HbA1c concentration levels did not change in rats exposed to lead. Our results well documented that lifetime exposure to lead affected carbohydrate metabolism of rats. Some parameters like concentration of Hb as well as activities of AMS and LDH are useful markers of intoxication of rats with lead. For the evaluation of results (e.g. AMS), not only the data at the end of the experiment should be taken into account but also the entire duration of trials (i.e. more time steps) that makes results more objective should be considered.
authors: Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia jaroslava.novakova@upjs.sk.
authors: Jaroslava
authors: J
authors: Nováková
authors: Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia.
authors: Agnesa
authors: A
authors: Lukačínová
authors: Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia.
authors: Eva
authors: E
authors: Lovásová
authors: Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia.
authors: Iveta
authors: I
authors: Cimboláková
authors: Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia.
authors: Oliver
authors: O
authors: Rácz
authors: Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia.
authors: František
authors: F
authors: Ništiar
mesh_terms: D000681:Amylases / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D004305:Dose-Response Relationship, Drug; D060766:Drinking Water / Q000737:chemistry; D006442:Glycated Hemoglobin / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007854:Lead / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000681:Amylases; D001786:Blood Glucose; D060766:Drinking Water; D006442:Glycated Hemoglobin; D006454:Hemoglobins; D007770:L-Lactate Dehydrogenase; D007854:Lead
keywords: Lead; amylase; carbohydrate metabolism; glucose; haemoglobin; lactate dehydrogenase; lifetime exposure; low dose; rat