title: Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation.
abstract: The easy vinyl sulfone derivatization of ferrocene allows the preparation of some effective, versatile and valuable ferrocenylation reagents. The applicability of such compounds in conjugation and bioconjugation of amine and/or thiol containing molecules and biomolecules through Michael-type addition under mild conditions that preserve the biological function of the latter is described. The feasibility of the methodology is demonstrated by the preparation of a variety of conjugates and bioconjugates (ferrocenyl terminated dendrimers and ferrocene-sugar, ferrocene-cyclodextrin, ferrocene-peptide and ferrocene-protein conjugates).
authors: Departamento de Q. Orgánica, Facultad de Ciencia, Instituto de Biotecnologia, Universidad de Granada, Granada, 18071 Spain.
authors: Alicia
authors: A
authors: Megia-Fernandez
authors: Fernando
authors: F
authors: Hernandez-Mateo
authors: Francisco
authors: F
authors: Santoyo-Gonzalez
mesh_terms: D000818:Animals; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry; D002417:Cattle; D004396:Coloring Agents / Q000138:chemical synthesis / Q000737:chemistry*; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry; D055664:Electrochemical Techniques; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D007202:Indicators and Reagents; D000075163:Metallocenes; D008958:Models, Molecular; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000138:chemical synthesis / Q000737:chemistry; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D004396:Coloring Agents; D003505:Cyclodextrins; D050091:Dendrimers; D005296:Ferrous Compounds; D007202:Indicators and Reagents; D000075163:Metallocenes; D010455:Peptides; D013450:Sulfones; D012710:Serum Albumin, Bovine; C009873:divinyl sulfone; C004998:ferrocene