title: Gastrin-induced proliferation involves MEK partner 1 (MP1).
abstract: The peptide hormone gastrin is an important factor for the maintenance and homeostasis of the gastric mucosa. We show that gastrin stimulates proliferation in a dose-dependent manner in the human gastric adenocarcinoma cell line AGS-GR. Furthermore, we demonstrate that the MAPK scaffold protein MEK partner 1 (MP1) is important for gastrin-induced phosphorylation of ERK1 and ERK2 and that MP1 promotes gastrin-induced proliferation of AGS-GR cells. Our results suggest a role of MP1 in gastrin-induced cellular responses involved in proliferation and homeostasis of the gastric mucosa.
authors: Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Postbox 8909, 7491, Trondheim, Norway. tonje.strommen@ntnu.no
authors: Tonje S
authors: TS
authors: Steigedal
authors: Wenche S
authors: WS
authors: Prestvik
authors: Linn-Karina M
authors: LK
authors: Selvik
authors: Christina S
authors: CS
authors: Fjeldbo
authors: Torunn
authors: T
authors: Bruland
authors: Astrid
authors: A
authors: Lægreid
authors: Liv
authors: L
authors: Thommesen
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005755:Gastrins / Q000008:administration & dosage*; D006706:Homeostasis; D006801:Humans; D048369:MAP Kinase Kinase 1 / Q000378:metabolism; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D005755:Gastrins; C485425:LAMTOR3 protein, human; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D048369:MAP Kinase Kinase 1