title: The role of serum cholinesterase activity and S100B protein in the evaluation of organophosphate poisoning.
abstract: The aim of this study was to investigate the role of serum cholinesterase (SChE) activity and S100B protein in the evaluation of patients with acute organophosphate (OP) poisoning. Patients with acute OP poisoning admitted to the emergency department were included in this cross-sectional study. Twenty healthy volunteers served as controls. The SChE activity and serum S100B were determined on admission. Patients were divided into two groups (low severity and high severity). Thirty-six patients diagnosed with acute OP poisoning were enrolled. Serum S100B concentrations were higher in patients than in the control group (p < 0.05). In the high-severity group, the SChE levels were lower and the S100Bs levels were higher than in the low-severity group. The SChE level was not different between survivors and nonsurvivors. S100B levels were higher in nonsurvivors than in survivors. According to receiver-operating characteristic curve analysis, the optimal cutoff value of serum S100B level to predict mortality was 236.5 pg/mL, with 71.4% sensitivity and 89.7% specificity. Our data suggest that initial SChE level is related to the clinical severity but not with mortality. S100B may be a useful marker in the assessment of clinical severity and prediction of mortality in acute OP poisoning.
authors: 1Department of Emergency Medicine, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors: T
authors: T
authors: Yardan
authors: A
authors: A
authors: Baydin
authors: E
authors: E
authors: Acar
authors: F
authors: F
authors: Ulger
authors: D
authors: D
authors: Aygun
authors: A
authors: A
authors: Duzgun
authors: R
authors: R
authors: Nar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002802:Cholinesterases / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D002802:Cholinesterases
keywords: Organophosphate poisoning; S100B protein; serum cholinesterase