title: Effects of statins on lipid profile in chronic kidney disease patients: a meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  The available data on statin effects in chronic kidney disease (CKD) patients are still conflicting. We investigated the impact of short- and long-term statin therapy on lipid profiles in CKD patients requiring or not requiring dialysis.
  
  
  METHODS
  Data from Scopus, PubMed, Web of Science, and the Cochrane Library from 1966 to May 2012 were searched for studies that investigated this effect. We included all randomized controlled clinical trials that investigated the impact of statin therapy on lipids and lipoproteins.
  
  
  RESULTS
  The final analysis included 16 trials with 3594 subjects. In CKD patients, statin therapy significantly reduced total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) (p < 0.003 for all comparisons), and the effect insignificantly intensified with duration of statin therapy (56.3 vs 66.8, 22.5 vs 24.1, and 53 vs 56.1 mg/dl, respectively). Comparing statin therapy for ≤ 3 and >3 months in CKD patients on dialysis, the magnitude of TC and LDL-C decreased (26.3 vs 25.9, and 42.2 vs 29.8 mg/dl, respectively, p > 0.05 for both), while TG increased modestly (4.5 vs 13.4 mg/dl). Short-term statin therapy increased high density lipoprotein cholesterol by a mean 0.7 mg/dl (p = 0.04), and long-term therapy was associated with a mean reduction of 2.4 mg/dL.
  
  
  CONCLUSIONS
  Statin therapy significantly modifies the lipid profile in CKD patients not on dialysis therapy (with the trend to be more effective with longer therapy), and have less beneficial effect in patients on dialysis with the trend to be less effective with longer duration of therapy.
authors: BioMedical Department of Internal Medicine and Medical Specialties, University of Palermo, Italy.
authors: Dragana
authors: D
authors: Nikolic
authors: Shekoufeh
authors: S
authors: Nikfar
authors: Pooneh
authors: P
authors: Salari
authors: Manfredi
authors: M
authors: Rizzo
authors: Kausik K
authors: KK
authors: Ray
authors: Michael J
authors: MJ
authors: Pencina
authors: Dimitri P
authors: DP
authors: Mikhailidis
authors: Peter P
authors: PP
authors: Toth
authors: Stephen J
authors: SJ
authors: Nicholls
authors: Jacek
authors: J
authors: Rysz
authors: Mohammad
authors: M
authors: Abdollahi
authors: Maciej
authors: M
authors: Banach
mesh_terms: D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008297:Male; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000628:therapy*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids