title: Evaluation of endocervical canal in women with minimal cervical cytological abnormalities.
abstract: OBJECTIVE
  This study aimed to examine the endocervical canal curettage (ECC) results of patients with atypical squamous cells of undetermined significance (ASC-US) or low-grade intraepithelial lesion (LSIL) and secondarily to explore the features of patients who are at greatest risk for endocervical involvement.
  
  
  METHODS
  This is a retrospective analysis of 846 women who underwent ECC with ASC-US or LSIL on cervical cytology between January 2003 and April 2011. Records of demographic data and colposcopic impression were evaluated. Histopathological results of biopsies and ECC were classified into 2 categories as less than cervical intraepithelial lesion 2 (CIN 2) and CIN 2+ lesions for comparison. Multivariate analysis was performed using binary logistic regression analysis to identify predictors of ECC results.
  
  
  RESULTS
  CIN 1 lesions were detected in 8.9% of patients, and the rates of CIN 2 or 3 and invasive/microinvasive cancers in ECC were 3.8% and 0.7%, respectively. Cervical intraepithelial lesion 2 or worse lesions were detected in 1.6% (7/419) of the patients with normal colposcopic findings. There was no statistically significant difference in the rate of CIN 2+ lesion in endocervical canal between the patients with or without satisfactory colposcopic examination (4.4% vs 4.1% p = .69). A total of 1.7% of the patients who did not have cervical biopsy and also 1.1% of the patients who had less than CIN 2 biopsy results were diagnosed with CIN 2+ lesion by ECC despite the satisfactory colposcopy. Only a positive biopsy result for dysplasia was found to be an independent factor for the detection of a dysplastic lesion in endocervical canal (odds ratio = 0.06; 95% CI = 0.01-0.35; p = .02).
  
  
  CONCLUSIONS
  Endocervical canal curettage had minimal diagnostic utility for the detection of CIN 2 or worse lesions in women with ASC-US or LSIL smear result and normal colposcopic findings. In addition to this, the presence or absence of CIN 2+ lesions diagnosed by means of endocervical curettage was independent of a satisfactory or unsatisfactory colposcopic examination.
authors: Obstetrics and Gynecology, Haseki Teaching and Research Hospital, Istanbul, Turkey. bpgoksedef@yahoo.com
authors: B Pinar Cilesiz
authors: BP
authors: Goksedef
authors: Ozgur
authors: O
authors: Akbayir
authors: Ceyhun
authors: C
authors: Numanoglu
authors: Aytul
authors: A
authors: Corbacioglu
authors: Hakan
authors: H
authors: Guraslan
authors: Lale Vuslat
authors: LV
authors: Bakir
authors: Onur
authors: O
authors: Kaya
authors: Gulden
authors: G
authors: Yanik
authors: Ahmet
authors: A
authors: Cetin
mesh_terms: D000328:Adult; D000368:Aged; D003475:Curettage; D003584:Cytological Techniques / Q000379:methods*; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D014481:United States; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology*