title: Incidence and clinical characteristics of inflammatory bowel disease in a developed region of Guangdong Province, China: a prospective population-based study.
abstract: OBJECTIVE
  The incidence of inflammatory bowel disease (IBD) is increasing in China with urbanization and socioeconomic development. There is however a lack of prospective, population-based epidemiology study on IBD in China. The aim of the study is to define the incidence and clinical characteristics of IBD in a developed region of Guangdong Province in China.
  
  
  METHODS
  A prospective, population-based incidence study was conducted from July 2011 to June 2012 in Zhongshan, Guangdong, China. All newly diagnosed IBD cases in Zhongshan were included.
  
  
  RESULTS
  In total, 48 new cases of IBD (17 Crohn's disease [CD]; 31 ulcerative colitis [UC]) were identified over a 1-year period from July 2011. Age-standardized incidence rates for IBD, UC, and CD were 3.14, 2.05, and 1.09 per 100,000 persons, respectively. The median age of UC was 38, and that of CD was 25. Terminal ileum involvement only (L1), isolated colonic disease (L2), and ileocolonic disease (L3) were reported in 24%, 6%, and 71% of patients with CD, respectively. Twenty-four percent of patients had coexisting upper gastrointestinal disease (L4). Inflammatory (B1), stricturing (B2), and penetrating (B3) behavior were seen in 65%, 24%, and 12% of CD patients, respectively. Fifty-nine percent of CD and 26% of UC patients had extra-intestinal manifestations.
  
  
  CONCLUSIONS
  This is the first prospective, population-based IBD epidemiological study in a developed region of China. The incidence of IBD is similar to that in Japan and Hong Kong but lower than that in South Korea and Western countries.
authors: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: Zhirong
authors: Z
authors: Zeng
authors: Zhenhua
authors: Z
authors: Zhu
authors: Yuyu
authors: Y
authors: Yang
authors: Weishan
authors: W
authors: Ruan
authors: Xiabiao
authors: X
authors: Peng
authors: Yuhuan
authors: Y
authors: Su
authors: Lin
authors: L
authors: Peng
authors: Jinquan
authors: J
authors: Chen
authors: Quan
authors: Q
authors: Yin
authors: Chao
authors: C
authors: Zhao
authors: Haihua
authors: H
authors: Zhou
authors: Shuai
authors: S
authors: Yuan
authors: Yuantao
authors: Y
authors: Hao
authors: Jiaming
authors: J
authors: Qian
authors: Siew Chien
authors: SC
authors: Ng
authors: Minhu
authors: M
authors: Chen
authors: Pinjin
authors: P
authors: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012923:Social Class; D013997:Time Factors; D014505:Urban Population / Q000706:statistics & numerical data*; D014506:Urban Renewal; D055815:Young Adult