title: Experimental research on the in vitro antitumor effects of Crataegus sanguinea.
abstract: Crataegus sanguinea is a wild plant, which has been widely grown in the north and south of the Tianshan mountains in Xinjiang. In order to explore their anti-cancer properties, edible wild plants from Xinjiang have been tested for their antitumor properties. We used Ames tests, mouse bone marrow polychromatic erythrocytes micronucleus tests, and tumor cells cultured in vitro to study the anti-mutagenic and anti-tumor effects of C. sanguinea extract. We have shown that C. sanguinea has anti-mutagenic effect, but no mutagenicity. Cell culture in vitro experiments show that there is no inhibition of growth or increase in cell death on normal mouse fibroblasts, but a stronger inhibition of cell growth and an increase in cell death of Hep-2 and MGC-803 tumor cells. The results of this study illustrate that C. sanguinea extract has both anti-mutagenic and anti-tumor effects.
authors: Department of Cardiology, Aviation General Hospital, An Ding Men Wai Bei Yuan Road 3, Beijing, 100012, China. sunjianling2000@yahoo.com.cn
authors: Jianling
authors: J
authors: Sun
authors: Guolan
authors: G
authors: Gao
authors: YuLian
authors: Y
authors: Gao
authors: LiJuan
authors: L
authors: Xiong
authors: Xiaoying
authors: X
authors: Li
authors: Jihong
authors: J
authors: Guo
authors: Yueming
authors: Y
authors: Zhang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D027825:Crataegus / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts