title: Polymorphous low-grade adenocarcinoma of the head and neck.
abstract: Polymorphous low-grade adenocarcinomas are rare tumors that can arise from many areas of the head and neck. We reviewed the pertinent literature pertaining to the incidence, diagnostic evaluation, and treatment strategies for this malignancy. Histopathologic diagnosis always involves careful analysis of tissue and especially characteristic immunohistochemical staining patterns. Common differential diagnoses include adenoid cystic carcinoma, pleomorphic adenoma, and other benign or malignant salivary gland neoplasms. Although the ideal treatment is debated, surgical resection at times combined with adjuvant radiation therapy is preferred by many physicians. Further research will be needed to delineate optimal management.
authors: Departments of *Radiation Oncology †Otolaryngology, University of Florida College of Medicine, Gainesville, FL.
authors: Vivek
authors: V
authors: Verma
authors: William M
authors: WM
authors: Mendenhall
authors: John W
authors: JW
authors: Werning
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008949:Adenoma, Pleomorphic / Q000175:diagnosis* / Q000473:pathology; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D060787:Neoplasm Grading; D018714:Radiotherapy, Adjuvant; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome