title: [Granulosa cell tumor of the ovary - analysis of 15 cases in a single institution].
abstract: The best treatment for recurrent granulosa cell tumor(GCT)is considered to be surgical resection, because the effects of chemotherapy or radiation on GCT are obscure. The common site of recurrence is the pelvic cavity, including the surface of the liver and intestine as tumor-dissemination-patterns. Between June 1988 and June 2011, we treated 15 patients with GCT at our hospital. The median follow-up time was 56(22-286)months. Ten patients were stage I, 3 were stage II, and 2 were stage III. No patients had residual lesions at the primary surgery area. Six patients have recurred, and the median disease free survival(DFS)was 85(15-128)months. Six patients had relapses in the pelvic cavity, 2 in the retroperitneal lymph nodes, and 1 in the upper abdomen. Two patients relapsed more than twice; however, the rapid detection of recurrence and surgical resection have kept all patients alive. Thirteen patients have no evidence of disease(NED), 2 are alive with disease(AWD), and no one has died of the disease(DOD). We suggest that maximal debulking surgery to achieve complete cytoreduction of recurrent GCT is the most important treatment for prolonging survival.
authors: Dept. of Obstetrics and Gynecology, Japanese Red Cross Nagoya Daiichi Hospital.
authors: Katsuhiko
authors: K
authors: Hiromura
authors: Mayuko
authors: M
authors: Ban
authors: Yoshiaki
authors: Y
authors: Maseki
authors: Sayako
authors: S
authors: Ikeda
authors: Kikyou
authors: K
authors: Onishi
authors: Akira
authors: A
authors: Yokoi
authors: Midori
authors: M
authors: Nakayama
authors: Akiko
authors: A
authors: Shinbo
authors: Mioko
authors: M
authors: Hando
authors: Ken
authors: K
authors: Miyazaki
authors: Kana
authors: K
authors: Kihira
authors: Tomoko
authors: T
authors: Ando
authors: Kimio
authors: K
authors: Mizuno
authors: Madoka
authors: M
authors: Furuhashi
authors: Masahiko
authors: M
authors: Fujino
authors: Masafumi
authors: M
authors: Ito
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D055815:Young Adult