title: Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA.
abstract: We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.
authors: Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, USA.
authors: Wenyu
authors: W
authors: Zhang
authors: David I
authors: DI
authors: Bryson
authors: Jason B
authors: JB
authors: Crumpton
authors: Jessica
authors: J
authors: Wynn
authors: Webster L
authors: WL
authors: Santos
mesh_terms: D000595:Amino Acid Sequence; D001897:Boronic Acids / Q000737:chemistry*; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D012367:RNA, Viral / Q000378:metabolism*
chemical_list: D001897:Boronic Acids; D019151:Peptide Library; D010455:Peptides; D012367:RNA, Viral