title: The relationship between psychological factors, inflammation, and nutrition in patients with chronic renal failure undergoing hemodialysis.
abstract: OBJECTIVE
  Hemodialysis has an adverse impact on the immunological, nutritional, and emotional status of patients. The biochemical markers of inflammation and nutrition were studied as well as the relationship of these factors to emotional symptoms.
  
  
  METHODS
  One hundred and ninety-five patients undergoing hemodialysis were enrolled. The mean age was 58.5 years. Emotional symptoms were assessed using the Mini International Neuropsychiatric Interview, Hospital Anxiety and Depression Scale, Chalder Fatigue Scale, and Short-form Health-related Quality of Life. Venus blood was collected for laboratory assessment of serum hemoglobin, albumin, ferritin, C-reactive protein, interleukin (IL) 1beta), IL-6, and tumor necrosis factor alpha.
  
  
  RESULTS
  Among the 195 subjects (92 men and 103 women), 47 (24.1%) fulfilled the criteria for a major depressive disorder (MDD). The IL-6 level in patients with a MDD was significantly higher than in the patients without a MDD. Significant correlation was observed among the following factors: IL-6, fatigue, and quality of life for both physical and mental components. The albumin levels showed a significant correlation with the IL-6 and depression scores.
  
  
  CONCLUSIONS
  These results show that the serum levels of albumin and IL-6 might be laboratory markers associated with the expression of emotional symptoms in patients undergoing hemodialysis. Prospective studies are needed to determine the causal relationships among these variables.
authors: Chang Gung Memorial Hospital at Keelung, Taiwan.
authors: Liang-Jen
authors: LJ
authors: Wang
authors: Mai-Szu
authors: MS
authors: Wu
authors: Heng-Jung
authors: HJ
authors: Hsu
authors: I-Wen
authors: IW
authors: Wu
authors: Chiao-Yin
authors: CY
authors: Sun
authors: Chia-Chi
authors: CC
authors: Chou
authors: Chin-Chan
authors: CC
authors: Lee
authors: Chi-Ren
authors: CR
authors: Tsai
authors: Yi-Chieh
authors: YC
authors: Tsai
authors: Chih-Ken
authors: CK
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D002097:C-Reactive Protein; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D003863:Depression / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D003865:Major Depressive Disorder / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D004644:Emotions; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000523:psychology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000523:psychology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D006435:Renal Dialysis / Q000523:psychology*
chemical_list: D016207:Cytokines; D002097:C-Reactive Protein