title: Early development of metabolic syndrome in patients subjected to lung transplantation.
abstract: Cardiovascular disease is a common cause of morbidity and mortality after solid organ transplantation, due to a combination of pre-existing cardiovascular risk factors and immunosuppressive drug toxicity. The prevalence of new-onset hypertension, dyslipidemia, diabetes mellitus, and metabolic syndrome was assessed after lung transplantation in a cohort of 67 patients (mean age: 48 ± 14 yr). The prevalence of hypertension increased from 19.4% to 70.1% at the three-yr follow-up visit (p < 0.01). The concomitant prevalence of diabetes and dyslipidemia raised from 13.4% to 31.3%, and from 6.0% to 40.3%, respectively (p < 0.01 for both), and body mass index increased from 22.4 ± 3.7 to 26.1 ± 3.9 kg/m(2) (p < 0.01). The prevalence of metabolic syndrome increased from 3.0% to 23.9% after the first year, to remain stable thereafter, associated with a strict control of cardiovascular risk factors. A large number of lung transplant recipients develop new-onset hypertension, diabetes, dyslipidemia after transplantation, and in more than one-fifth metabolic syndrome can be diagnosed after the first year. The increased cardiovascular risk of these patients should be taken into account during follow-up, to better define a proper and timely cardiovascular prevention. Adequate control of cardiovascular risk factors, preventing further metabolic syndrome development, is recommended and feasible in lung transplant recipients.
authors: Clinica Medica II, Department of Internal Medicine, Fondazione Policlinico IRCCS San Matteo, University of Pavia, Pavia, Italy.
authors: Gabriele
authors: G
authors: Savioli
authors: Sara
authors: S
authors: Surbone
authors: Ilaria
authors: I
authors: Giovi
authors: Francesco
authors: F
authors: Salinaro
authors: Paola
authors: P
authors: Preti
authors: Federica
authors: F
authors: Meloni
authors: Tiberio
authors: T
authors: Oggionni
authors: Stefano
authors: S
authors: Perlini
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology; D050171:Dyslipidemias / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology; D007558:Italy / Q000453:epidemiology; D008171:Lung Diseases / Q000150:complications* / Q000601:surgery; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology; D008875:Middle Aged; D011183:Postoperative Complications; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors