title: Relationships between maternal novel adipocytokines and bone biomarkers in complicated by gestational hypertensive disorders and normal pregnancies.
abstract: OBJECTIVE
  To investigate possible associations of the novel adipocytokines resistin, apelin and visfatin (implicated in the complex control of bone biology) with several biochemical determinants of bone turnover in maternal blood from normal pregnancies and pregnancies complicated by gestational hypertensive disorders (preeclampsia or pregnancy-induced hypertension).
  
  
  METHODS
  Circulating maternal concentrations of resistin, apelin and visfatin were correlated with circulating markers of bone formation [osteocalcin (OC), bone-specific alkaline phosphatase (BALP)] and resorption [osteoprotegerin (OPG), soluble receptor activator of nuclear factor-κB ligand (sRANKL) and cross-linked N-telopeptide of type I collagen (NTx)] in full-term pregnancies (20 normal and 20 complicated by gestational hypertensive disorders).
  
  
  RESULTS
  In normal pregnancies, no correlation was recorded between maternal concentrations of adipocytokines and the above bone biomarkers. In pregnancies with gestational hypertensive disorders, maternal apelin concentrations negatively correlated with NTx ones (r = -0.489, p = 0.034), while maternal visfatin concentrations positively correlated with OPG ones (r = 0.464, p = 0.039).
  
  
  CONCLUSIONS
  No associations were found between maternal concentrations of all three studied adipocytokines and respective concentrations of bone biomarkers in normal pregnancies. By contrast, in pregnancies with gestational hypertensive disorders, maternal concentrations of apelin and visfatin correlated with respective concentrations of indices of bone turnover. Further prospective studies are needed to clarify these relationships.
authors: Neonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece.
authors: Despina D
authors: DD
authors: Briana
authors: Maria
authors: M
authors: Boutsikou
authors: Theodora
authors: T
authors: Boutsikou
authors: Ariadne
authors: A
authors: Malamitsi-Puchner
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000073861:Apelin; D015415:Biomarkers / Q000097:blood; D001862:Bone Resorption; D016022:Case-Control Studies; D024042:Collagen Type I / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D015675:Osteocalcin / Q000097:blood; D010012:Osteogenesis; D053244:Osteoprotegerin / Q000097:blood; D010455:Peptides / Q000097:blood; D011247:Pregnancy; D053245:RANK Ligand / Q000097:blood; D052243:Resistin / Q000097:blood*; D055815:Young Adult
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D015415:Biomarkers; D024042:Collagen Type I; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D053244:Osteoprotegerin; D010455:Peptides; D053245:RANK Ligand; D052243:Resistin; C505688:TNFSF11 protein, human; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human; D000469:Alkaline Phosphatase