title: Secretory meningiomas: clinical, radiological and pathological findings in 70 consecutive cases at one institution.
abstract: Secretory meningioma (SM) is a rare, benign subtype of meningioma. Between January 2005 and December 2010, 70 SMs were operated on at the Department of Neurosurgery, Huashan Hospital, Fudan University. We retrospectively analyzed the clinical data, radiological and immunohistochemical findings, and patient outcome to discuss the specific features of SMs. Cranial base preference, hyper-signal in T2 weighted MR image, "xenon light" gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) enhancement were frequently observed in the 70 cases. Non-skull base SMs, which received more complete resection (p<0.01) and had better short-term and long-term outcome, were observed with more severe peritumoral brain edema (PTBE) (p<0.001). In follow-up, only 1 cranial base SM case showed tumor progression. 3 cases died after operation, all with cranial base SMs. As for the 10 cases given Simpson grade 3 or 4 resection who were available at follow-up, 3 died, 5 received gamma-knife therapy, and the other 2 cases received no treatment at all. Only one of the 2 residual SMs without postoperative radiation presented minor progression at a median of 48 months follow-up. In conclusion, cranial base preference, hyper-signal T2 weighted MR image and "xenon light" GD-DTPA enhancement are specific for SMs. Prognosis of SMs is related with operation completeness and surgical risks, rather than the extent of PTBE. Residual SM grows slowly and reacts well to gamma-knife therapy.
authors: Department of Neurosurgery, Fudan University Shanghai, China.
authors: Dai-Jun
authors: DJ
authors: Wang
authors: Qing
authors: Q
authors: Xie
authors: Ye
authors: Y
authors: Gong
authors: Yin
authors: Y
authors: Wang
authors: Hai-Xia
authors: HX
authors: Cheng
authors: Ying
authors: Y
authors: Mao
authors: Ping
authors: P
authors: Zhong
authors: Feng-Ping
authors: FP
authors: Huang
authors: Kang
authors: K
authors: Zheng
authors: Yong-Fei
authors: YF
authors: Wang
authors: Wei-Min
authors: WM
authors: Bao
authors: Bo-Jie
authors: BJ
authors: Yang
authors: Hong
authors: H
authors: Chen
authors: Li-Qian
authors: LQ
authors: Xie
authors: Ming-Zhe
authors: MZ
authors: Zheng
authors: Hai-Liang
authors: HL
authors: Tang
authors: Hong-Da
authors: HD
authors: Zhu
authors: Xian-Cheng
authors: XC
authors: Chen
authors: Liang-Fu
authors: LF
authors: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography / Q000379:methods*; D016634:Radiosurgery; D012189:Retrospective Studies
keywords: Location; prognosis; radiology; secretory meningiomas