title: crcTRP: a translational research platform for colorectal cancer.
abstract: Colorectal cancer is a leading cause of cancer mortality in both developed and developing countries. Transforming basic research results into clinical practice is one of the key tasks of translational research, which will greatly improve the diagnosis and treatments of colorectal cancer. In this paper, a translational research platform for colorectal cancer, named crcTRP, is introduced. crcTRP serves the colorectal cancer translational research by providing various types of biomedical information related with colorectal cancer to the community. The information, including clinical data, epidemiology data, individual omics data, and public omics data, was collected through a multisource biomedical information collection solution and then integrated in a clinic-omics database, which was constructed with EAV-ER model for flexibility and efficiency. A preliminary exploration of conducting translational research on crcTRP was implemented and worked out a set of clinic-genomic relations, linking clinical data with genomic data. These relations have also been applied to crcTRP to make it more conductive for cancer translational research.
authors: Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, China.
authors: Ning
authors: N
authors: Deng
authors: Ling
authors: L
authors: Zheng
authors: Fang
authors: F
authors: Liu
authors: Li
authors: L
authors: Wang
authors: Huilong
authors: H
authors: Duan
mesh_terms: D000465:Algorithms; D035843:Biomedical Research; D002874:Chromosome Mapping / Q000379:methods; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D019295:Computational Biology / Q000379:methods*; D003627:Data Interpretation, Statistical; D023281:Genomics; D006801:Humans; D020407:Internet; D016347:Medical Records Systems, Computerized; D014057:Tomography, X-Ray Computed / Q000379:methods; D057170:Translational Research, Biomedical / Q000379:methods*