title: Somatic mutation patterns and compound response in cancers.
abstract: The use of various cancer cell lines can recapitulate known tumor-associated mutations and genetically define cancer subsets. This approach also enables comparative surveys of associations between cancer mutations and drug responses. Here, we analyzed the effects of ~40,000 compounds on cancer cell lines that showed diverse mutation-dependent sensitivity profiles. Over 1,000 compounds exhibited unique sensitivity on cell lines with specific mutational genotypes, and these compounds were clustered into six different classes of mutation-oriented sensitivity. The present analysis provides new insights into the relationship between somatic mutations and selectivity response of chemicals, and these results should have applications related to predicting and optimizing therapeutic windows for anti-cancer agents.
authors: Department of Biological Sciences, Sookmyung Women's University, Seoul 140-742, Korea.
authors: Ningning
authors: N
authors: He
authors: Nayoung
authors: N
authors: Kim
authors: Sukjoon
authors: S
authors: Yoon
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D016000:Cluster Analysis; D016208:Databases, Factual; D020869:Gene Expression Profiling; D005838:Genotype; D006801:Humans; D009154:Mutation / Q000187:drug effects*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D054852:Small Molecule Libraries / Q000494:pharmacology; D012984:Software
chemical_list: D000970:Antineoplastic Agents; D054852:Small Molecule Libraries