title: Current and evolving knowledge of prognostic factors for pediatric ependymomas.
abstract: Ependymomas are one of the most common pediatric malignant brain tumors. Prognosis, especially in young children, remains poor due to their inherent chemo- and radio-resistance and effective treatment remains one of the more difficult tasks in pediatric oncology: up to half of the patients may die from the disease. The only reproducible prognostic factor is the extent of surgery; neither histological grading nor other biomarkers can be used to reliably make treatment decisions in clinical practice. None of the studies identifying new biomarkers have been conducted prospectively, only few have been undertaken within the context of a clinical trial and most have been conducted with limited samples (often including adults and childhood samples). International collaboration is needed to improve ependymoma prognostication.
authors: Centre National de la Recherche Scientifique Unité Mixte de Recherche 8203 Vectorology & Anticancer Therapeutics, Gustave Roussy Cancer Institute, Paris-Sud University, Villejuif, France.
authors: Felipe
authors: F
authors: Andreiuolo
authors: Céline
authors: C
authors: Ferreira
authors: Stéphanie
authors: S
authors: Puget
authors: Jacques
authors: J
authors: Grill
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D018450:Disease Progression; D004806:Ependymoma / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000401:mortality; D020869:Gene Expression Profiling; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor