title: Tubulointerstitial nephritis and primary biliary cirrhosis with a T cell-dominant profile of infiltrating cells and granulomas in both organs.
abstract: A 46-year-old woman was admitted to our hospital for an evaluation of progressive renal insufficiency and elevated liver enzymes. A renal biopsy revealed chronic granulomatous interstitial nephritis. Her laboratory findings indicated primary biliary cirrhosis (PBC), which was confirmed with a liver biopsy. CD4(+) T cells and CD8(+) T cells with granuloma formation were the predominant cells infiltrating into the interstitium of the kidneys and liver. The etiology of tubulointerstitial nephritis in the present patient was not clear; however, it might have shared the same pathogenesis as PBC due to the relatively close onset, the similar profiles of infiltrating cells and the presence of granulomas.
authors: Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Japan.
authors: Takamasa
authors: T
authors: Iwakura
authors: Yoshihide
authors: Y
authors: Fujigaki
authors: Takashi
authors: T
authors: Matsuyama
authors: Tomoyuki
authors: T
authors: Fujikura
authors: Naro
authors: N
authors: Ohashi
authors: Hideo
authors: H
authors: Yasuda
authors: Akihiko
authors: A
authors: Kato
authors: Satoshi
authors: S
authors: Baba
mesh_terms: D005260:Female; D006099:Granuloma / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000276:immunology*; D008107:Liver Diseases / Q000150:complications*; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications* / Q000276:immunology*; D013601:T-Lymphocytes