title: Further insecticidal activities of essential oils from Lippia sidoides and Croton species against Aedes aegypti L.
abstract: This study assessed new insecticidal activities of essential oils from Lippia sidoides and Croton species (Croton zehntneri, Croton nepetaefolius, Croton argyrophylloides, and Croton sonderianus) against Aedes aegypti mosquito. In addition, the acute toxicity upon mice was determined. All essential oils showed inhibition of egg hatching, with IC50 values ranging from 66.4 to 143.2 μg mL(-1), larvicidal activity with LC50 ranging from 25.5 to 94.6 μg mL(-1), and pupicidal action with PC50 ranging from 276.8 to over 500 μg mL(-1). Only L. sidoides, C. zehntneri, and C. argyrophylloides essential oils were able to inhibit the oviposition of female gravid mosquitoes with OD50 values of 35.3, 45.3, and 45.8 μg mL(-1), respectively. Oral acute toxicity in mice showed that C. sonderianus and C. argyrophylloides oils are nontoxic (LD50 > 6,000 mg.kg(-1)) while C. nepetaefolius, C. zehntneri, and L. sidoides oils are moderately toxic (LD50 3,840; 3,464, and 2,624 mg.kg(-1), respectively). The results indicate that these oils are promising sources of bioactive compounds, showing low or no toxicity to mammals.
authors: Department of Biochemistry and Molecular Biology, Campus Pici, Federal University of Ceara, 60455-760, Fortaleza, Ceara, Brazil.
authors: Glauber Pacelli Gomes
authors: GP
authors: de Lima
authors: Terezinha Maria
authors: TM
authors: de Souza
authors: Gabrielle
authors: G
authors: de Paula Freire
authors: Davi Felipe
authors: DF
authors: Farias
authors: Arcelina Pacheco
authors: AP
authors: Cunha
authors: Nágila Maria Pontes Silva
authors: NM
authors: Ricardo
authors: Selene Maia
authors: SM
authors: de Morais
authors: Ana Fontenele Urano
authors: AF
authors: Carvalho
mesh_terms: D000330:Aedes / Q000033:anatomy & histology / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D029802:Croton / Q000737:chemistry*; D005260:Female; D007306:Insecticides / Q000494:pharmacology* / Q000633:toxicity; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D032411:Lippia / Q000737:chemistry*; D051379:Mice; D009822:Oils, Volatile / Q000494:pharmacology* / Q000633:toxicity; D010058:Oviposition / Q000187:drug effects; D010063:Ovum / Q000187:drug effects / Q000254:growth & development; D010938:Plant Oils / Q000494:pharmacology / Q000633:toxicity; D013045:Species Specificity
chemical_list: D007306:Insecticides; D009822:Oils, Volatile; D010938:Plant Oils