title: New spiral γ-lactone enantiomers from the plant endophytic fungus Pestalotiopsis foedan.
abstract: (-)-(4S, 8S)-Foedanolide (1a) and (+)-(4R, 8R)-foedanolide (1b), a pair of new spiro-γ-lactone enantiomers, were isolated from the fermentation broth of the plant endophytic fungus Pestalotiopsis foedan by HPLC using a chiral column, achieving over 7% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the electronic circular dichroism (ECD) and optical rotation (OR). Compounds 1a and 1b showed moderate activities against HeLa, A-549, U-251, HepG2 and MCF-7 tumor cell lines.
authors: College of Pharmaceutical Science, Hebei University, Baoding 071002, Hebei, China. yxl19830915@163.com
authors: Xiao-Long
authors: XL
authors: Yang
authors: Zhuang-Zhuang
authors: ZZ
authors: Li
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010944:Plants / Q000382:microbiology*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D007783:Lactones