title: Preexisting interstitial lung disease is inversely correlated to tumor epidermal growth factor receptor mutation in patients with lung adenocarcinoma.
abstract: BACKGROUND
  Interstitial lung disease (ILD), especially idiopathic pulmonary fibrosis, has been shown to be associated with lung carcinogenesis. However, an association between epidermal growth factor receptor (EGFR) mutation status and preexisting ILD in patients with lung adenocarcinoma is unknown.
  
  
  METHODS
  Between January 2008 and April 2012, we analyzed 602 patients with lung adenocarcinoma. EGFR mutation status was analyzed using the peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp method, and preexisting ILD was diagnosed based on clinical features, chest high-resolution computed tomography (HRCT) findings, and histological findings.
  
  
  RESULTS
  There were 555 patients with pulmonary adenocarcinoma with tumor EGFR mutation data available for analysis. Of them, 31 patients (6%) had preexisting ILD, and EGFR mutations were detected in 246 of the 555 patients (46%). In the comparison between patients with EGFR mutations and those with wild-type EGFR, there was a significant inverse association between occurrence of tumors with EGFR mutations and ILD (1/246 vs. 30/309, P<0.001). Based on the multivariate analysis of age, gender, smoking status, Eastern Cooperative Oncology Group Performance Status, stage, and ILD, EGFR mutations were found to be independently associated with females (OR, 1.58; 95% CI, 1.01-2.46; P=0.048), never-smokers (OR, 3.31; 95% CI, 2.12-5.20; P<0.001), and the absence of ILD (OR, 17.41; 95% CI, 3.54-315.34; P<0.001).
  
  
  CONCLUSIONS
  This study showed that patients with pulmonary adenocarcinoma and ILD had a lower probability of carrying tumor EGFR mutations.
authors: Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan. daichi@kcho.jp
authors: Daichi
authors: D
authors: Fujimoto
authors: Keisuke
authors: K
authors: Tomii
authors: Takehiro
authors: T
authors: Otoshi
authors: Takahisa
authors: T
authors: Kawamura
authors: Koji
authors: K
authors: Tamai
authors: Junpei
authors: J
authors: Takeshita
authors: Kosuke
authors: K
authors: Tanaka
authors: Takeshi
authors: T
authors: Matsumoto
authors: Kazuya
authors: K
authors: Monden
authors: Kazuma
authors: K
authors: Nagata
authors: Kyoko
authors: K
authors: Otsuka
authors: Atsushi
authors: A
authors: Nakagawa
authors: Akito
authors: A
authors: Hata
authors: Ryo
authors: R
authors: Tachikawa
authors: Kojiro
authors: K
authors: Otsuka
authors: Hiroshi
authors: H
authors: Hamakawa
authors: Nobuyuki
authors: N
authors: Katakami
authors: Yutaka
authors: Y
authors: Takahashi
authors: Yukihiro
authors: Y
authors: Imai
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D014057:Tomography, X-Ray Computed
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors