title: Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents.
abstract: A number of linezolid-like oxazolidino-sulfonamides (7a-y and 8a-b) were designed and synthesized with a view to develop antimicrobial agents with improved properties. Most of the synthesized compounds showed good to moderate activity against a panel of standard Gram-positive and Gram-negative bacteria and fungal strains. The compounds 7i and 7v exhibited significant activity, with a MIC value of 2.0-6.0 μg/mL against a panel of Gram-positive and Gram-negative bacteria. These compounds also showed activity against Candida albicans, with a MIC value of 4.0 μg/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented.
authors: Division of Organic Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.res.in
authors: Ahmed
authors: A
authors: Kamal
authors: P
authors: P
authors: Swapna
authors: Rajesh V C R N C
authors: RV
authors: Shetti
authors: Anver Basha
authors: AB
authors: Shaik
authors: M P
authors: MP
authors: Narasimha Rao
authors: Soma
authors: S
authors: Gupta
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010080:Oxazoles / Q000737:chemistry; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010080:Oxazoles; D013449:Sulfonamides; C064210:oxazolidine