title: Collagen membrane alleviates peritendinous adhesion in the rat Achilles tendon injury model.
abstract: BACKGROUND
  Tendon adhesion is one of the most common causes of disability following tendon surgery. Therefore, prevention of peritendinous adhesion after surgical repair of tendon is a major challenge. The aim of this study was to explore the possible application of a collagen membrane for the prevention or attenuation of peritendinous adhesions.
  
  
  METHODS
  Sprague-Dawley (SD) rat Achilles tendon was cut and sutured by a modified Kessler's technique with or without the collagen membrane wrapped. Macroscopic, morphological and biomechanical evaluations were applied to examine the recovery of the injured tendon at 4 and 8 weeks after surgery.
  
  
  RESULTS
  The surgery group wrapped by collagen membranes had a better outcome than the group with surgery repair only. In the collagen membrane-treated group, less adhesion appeared, stronger tensile strength was detected, and more tendon fibers and collagen I expression were observed morphologically.
  
  
  CONCLUSIONS
  Wrapping the tendon with a collagen membrane may be an efficient approach for tendon repair and preventing tendon adhesion after its ruptures.
authors: Department of Orthopedic Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
authors: Huan
authors: H
authors: Zhao
authors: Hong-geng
authors: HG
authors: Guan
authors: Jun
authors: J
authors: Gu
authors: Zong-ping
authors: ZP
authors: Luo
authors: Wen
authors: W
authors: Zhang
authors: Bing
authors: B
authors: Chen
authors: Qiao-li
authors: QL
authors: Gu
authors: Hui-lin
authors: HL
authors: Yang
authors: Qin
authors: Q
authors: Shi
mesh_terms: D000125:Achilles Tendon / Q000293:injuries*; D000818:Animals; D003094:Collagen; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013708:Tendon Injuries / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control*; D014945:Wound Healing
chemical_list: D003094:Collagen