title: Potential role of curcumin and taurine combination therapy on human myeloid leukemic cells propagated in vitro.
abstract: Curcumin and taurine are natural products that have been used in this study evaluating their therapeutic effect on myeloid leukemic cells propagated in vitro. Sixty patients with myeloid leukemia and 30 healthy volunteers were enrolled in the study. All patient groups were admitted to the Medical Oncology Department of the National Cancer Institute, Cairo University. There were statistically significant differences between treated leukemic cells compared to normal mononuclear leukocytes in cell density, interferon-γ and immunophenotypic profile, mainly CD4+, CD8 + and CD25+. This work highlights the possibility of using curcumin and taurine as a potential useful therapy in the management of patients suffering from chronic and acute myeloid leukemias.
authors: Cancer Biology Department, NCI, Cairo University , Egypt.
authors: Motawa E
authors: ME
authors: El-Houseini
authors: Mohammed Osman
authors: MO
authors: Refaei
authors: Ahmed Ibrahim
authors: AI
authors: Amin
authors: Mahmoud A
authors: MA
authors: Abol-Ftouh
mesh_terms: D000328:Adult; D015704:CD4 Antigens / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007371:Interferon-gamma / Q000096:biosynthesis; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D007951:Leukemia, Myeloid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013654:Taurine / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens; D004338:Drug Combinations; D053645:Interleukin-2 Receptor alpha Subunit; D013654:Taurine; D007371:Interferon-gamma; D003474:Curcumin