title: Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats.
abstract: Pterostilbene, found in grapes and berries, exhibits pleiotropic effects, including anti-inflammatory, antioxidant, and anti-proliferative activities. This study was conducted to investigate the effect of pterostilbene on liver fibrosis and the potential underlying mechanism for such effect. Sprague-Dawley rats were intraperitoneally given dimethyl n-nitrosamine (DMN) (10mg/kg) 3 days per week for 4 weeks. Pterostilbene (10 or 20mg/kg) was administered by oral gavage daily. Liver function, morphology, histochemistry, and fibrotic parameters were examined. Pterostilbene supplementation alleviated the DMN-induced changes in the serum levels of alanine transaminase and aspartate transaminase (p<0.05). Fibrotic status and the activation of hepatic stellate cells were improved upon pterostilbene supplementation as evidenced by histopathological examination as well as the expression of α-smooth muscle actin (α-SMA), transforming growth factor-β1 (TGF-β1), and matrix metalloproteinase 2 (MMP2). These data demonstrated that pterostilbene exhibited hepatoprotective effects on experimental fibrosis, potentially by inhibiting the TGF-β1/Smad signaling.
authors: Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan, ROC.
authors: Ming-Fen
authors: MF
authors: Lee
authors: Min-Lung
authors: ML
authors: Liu
authors: An-Chin
authors: AC
authors: Cheng
authors: Mei-Ling
authors: ML
authors: Tsai
authors: Chi-Tang
authors: CT
authors: Ho
authors: Wen-Shiung
authors: WS
authors: Liou
authors: Min-Hsiung
authors: MH
authors: Pan
mesh_terms: D000818:Animals; D004128:Dimethylnitrosamine / Q000009:adverse effects*; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics / Q000517:prevention & control*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013267:Stilbenes / Q000008:administration & dosage*; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism
chemical_list: D013267:Stilbenes; D053773:Transforming Growth Factor beta1; C107773:pterostilbene; D020778:Matrix Metalloproteinase 2; D004128:Dimethylnitrosamine