title: Sensitive voltammetric determination of paracetamol by poly (4-vinylpyridine)/multiwalled carbon nanotubes modified glassy carbon electrode.
abstract: A novel glassy carbon electrode (GCE) modified with a composite film of poly (4-vinylpyridine) (P4VP) and multiwalled carbon nanotubes (P4VP/MWCNT GCE) was used for the voltammetric determination of paracetamol (PCT). This novel electrode displayed a combined effect of P4VP and MWCNT on the electro-oxidation of PCT in a solution of phosphate buffer at pH 7. Hence, conducting properties of P4VP along with the remarkable physical properties of MWCNTs might have combined effects in enhancing the kinetics of PCT oxidation. The P4VP/MWCNT GCE has also demonstrated excellent electrochemical activity toward PCT oxidation compared to that with bare GCE and MWCNT GCE. The anodic peak currents of PCT on the P4VP/MWCNT GCE were about 300 fold higher than that of the non-modified electrodes. By applying differential pulse voltammetry technique under optimized experimental conditions, a good linear ratio of oxidation peak currents and concentrations of PCT over the range of 0.02-450 μM with a limit of detection of 1.69 nM were achieved. This novel electrode was stable for more than 60 days and reproducible responses were obtained at 99% of the initial current of PCT without any influence of physiologically common interferences such as ascorbic acid and uric acid. The application of this electrode to determine PCT in tablets and urine samples was proposed.
authors: Pusat Pengajian Sains Kimia, Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia.
authors: Hanieh
authors: H
authors: Ghadimi
authors: Ramin M A
authors: RM
authors: Tehrani
authors: Abdussalam Salhin Mohamed
authors: AS
authors: Ali
authors: Norita
authors: N
authors: Mohamed
authors: Sulaiman
authors: S
authors: Ab Ghani
mesh_terms: D000082:Acetaminophen / Q000032:analysis* / Q000652:urine; D001205:Ascorbic Acid / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D055664:Electrochemical Techniques; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D011145:Polyvinyls / Q000737:chemistry*; D014527:Uric Acid / Q000737:chemistry
chemical_list: D037742:Nanotubes, Carbon; D011145:Polyvinyls; C019535:poly(4-vinylpyridine); D014527:Uric Acid; D000082:Acetaminophen; D002244:Carbon; D001205:Ascorbic Acid