title: Interstitial collagen catabolism.
abstract: Interstitial collagen mechanical and biological properties are altered by proteases that catalyze the hydrolysis of the collagen triple-helical structure. Collagenolysis is critical in development and homeostasis but also contributes to numerous pathologies. Mammalian collagenolytic enzymes include matrix metalloproteinases, cathepsin K, and neutrophil elastase, and a variety of invertebrates and pathogens possess collagenolytic enzymes. Components of the mechanism of action for the collagenolytic enzyme MMP-1 have been defined experimentally, and insights into other collagenolytic mechanisms have been provided. Ancillary biomolecules may modulate the action of collagenolytic enzymes.
authors: Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL 34987, USA. gfields@tpims.org
authors: Gregg B
authors: GB
authors: Fields
mesh_terms: D000818:Animals; D001168:Arthritis / Q000378:metabolism; D001665:Binding Sites; D002384:Catalysis; D056657:Cathepsin K / Q000378:metabolism*; D003094:Collagen / Q000737:chemistry / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D019272:Leukocyte Elastase / Q000378:metabolism*; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D008660:Metabolism; D008968:Molecular Conformation; D009369:Neoplasms / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D012694:Serine / Q000737:chemistry; D013379:Substrate Specificity
chemical_list: D012694:Serine; D003094:Collagen; D019272:Leukocyte Elastase; D056657:Cathepsin K; D020782:Matrix Metalloproteinases; D020781:Matrix Metalloproteinase 1