title: Role of NHE1 in Nociception.
abstract: Intracellular pH is a fundamental parameter to cell function that requires tight homeostasis. In the absence of any regulation, excessive acidification of the cytosol would have the tendency to produce cellular damage. Mammalian Na(+)/H(+) exchangers (NHEs) are electroneutral Na(+)-dependent proteins that exchange extracellular Na(+) for intracellular H(+). To date, there are 9 identified NHE isoforms where NHE1 is the most ubiquitous member, known as the housekeeping exchanger. NHE1 seems to have a protective role in the ischemia-reperfusion injury and other inflammatory diseases. In nociception, NHE1 is found in neurons along nociceptive pathways, and its pharmacological inhibition increases nociceptive behavior in acute pain models at peripheral and central levels. Electrophysiological studies also show that NHE modulates electrical activity of primary nociceptive terminals. However, its role in neuropathic pain still remains controversial. In humans, NHE1 may be responsible for inflammatory bowel diseases since its expression is reduced in Crohn's disease and ulcerative colitis. The purpose of this work is to provide a review of the evidence about participation of NHE1 in the nociceptive processing.
authors: Centro de Investigación y Posgrado y División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, 86040 Villahermosa, TAB, Mexico ; Hospital Regional de Alta Especialidad "Dr. Juan Graham Casasús", 86126 Villahermosa, TAB, Mexico.
authors: Jorge Elías
authors: JE
authors: Torres-López
authors: Crystell Guadalupe
authors: CG
authors: Guzmán-Priego
authors: Héctor Isaac
authors: HI
authors: Rocha-González
authors: Vinicio
authors: V
authors: Granados-Soto