title: Intestinal mucormycosis: a rare entity in pediatric oncology.
abstract: Mucormycosis is increasingly emerging as an important cause of invasive fungal infection in immunocompromised patients. Intestinal mucormycosis is extremely rare, difficult to diagnose, and has dismal prognosis. We report two children with acute lymphoblastic leukemia and intestinal mucormycosis. Despite surgery and appropriate antifungal therapy, only one survived. Literature review showed only 10 other childhood cancer cases with intestinal mucormycosis. All had abdominal pain preceding gut perforation. All except one had leukemia and majority were in induction phase of therapy. Only 5 of these 12 children survived. Other than appropriate antifungal therapy, early surgery and rising neutrophils aid in recovery.
authors: Department of Pediatrics, Pediatric Hematology Oncology & BMT Unit, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India.
authors: Nita
authors: N
authors: Radhakrishnan
authors: Satya Prakash
authors: SP
authors: Yadav
authors: Jaswinder
authors: J
authors: Oberoi
authors: Rajeev
authors: R
authors: Kulshreshta
authors: Sunita
authors: S
authors: Bhalla
authors: Anupam
authors: A
authors: Sachdeva
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D007422:Intestines / Q000187:drug effects / Q000382:microbiology* / Q000473:pathology; D008297:Male; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D011379:Prognosis
chemical_list: D000935:Antifungal Agents