title: Case report: Teriparatide treatment in a case of severe pregnancy -and lactation- associated osteoporosis.
abstract: OBJECTIVE
  Pregnancy- and lactation-associated osteoporosis (PLO) is an uncommon disease. The majority of cases are seen in the third trimester or early post-partum in primagravid women and the prominent clinical feature of PLO is severe and prolonged back pain and height loss. The prevalence and aetiology of this disorder are as yet unclear and there are no guidelines for its treatment.
  
  
  METHODS
  We report the outcomes of teriparatide (TRP) treatment in a woman suffering from severe PLO with 6 vertebral fragility fractures, severe back pain and very low BMD.
  
  
  RESULTS
  Thirteen months after the initiation of therapy, the patient was almost free of back pain. There was no new clinical vertebral fracture. Her laboratory tests were all normal. BMD increased by 24.4% at the lumbar spine, 9.9% and 4.6% at the left and the right total hip and 12.6% and 7.8% at the left and right femur neck, respectively.
  
  
  CONCLUSIONS
  TRP treatment simultaneously with weaning and calcium and vitamin D supplementation seems to considerably increase BMD, improve severe back pain and quality of life and prevent further occurrence of vertebral fractures, making TRP a helpful tool in restoring bone strength in PLO patients.
authors: Laboratory for the Research of the Musculoskeletal System Th. Garofalidis, KAT Hospital, Athens, Greece. kilampropoulou@gmail.com
authors: Kalliopi
authors: K
authors: Lampropoulou-Adamidou
authors: George
authors: G
authors: Trovas
authors: Ioannis P
authors: IP
authors: Stathopoulos
authors: Nikolaos A
authors: NA
authors: Papaioannou
mesh_terms: D000328:Adult; D001416:Back Pain / Q000188:drug therapy / Q000209:etiology; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002136:Calcium, Dietary / Q000627:therapeutic use; D002762:Cholecalciferol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007774:Lactation; D008159:Lumbar Vertebrae / Q000293:injuries; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy; D011644:Puerperal Disorders / Q000188:drug therapy*; D016103:Spinal Fractures / Q000209:etiology* / Q000517:prevention & control; D019379:Teriparatide / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D002136:Calcium, Dietary; D019379:Teriparatide; D002762:Cholecalciferol