title: Uninodular combined hepatocellular and cholangiocarcinoma with multiple non-neoplastic hypervascular lesions appearing in the liver of a patient with HIV and HCV coinfection.
abstract: A 42-year-old man suffering from haemophilia A and coinfection of human immunodeficiency virus (HIV) and hepatitis C virus was referred to our institution because of multiple liver tumours. He had been receiving highly active antiretroviral therapy for HIV infection. Ultrasonography showed multiple hypoechoic space-occupying lesions in the liver. Contrast-enhanced dynamic computed tomography (CT) and magnetic resonance imaging revealed multiple ring-enhanced hypervascular lesions in the liver. An ultrasonography-guided biopsy was performed and histological evaluation indicated one of the lesions to be combined hepatocellular and cholangiocarcinoma and others to be non-neoplastic. The patient underwent partial hepatic resection and is currently alive without recurrence for 15 months. Multiple ring-enhanced lesions have been undetectable in postoperative follow-up CT examinations.
authors: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Koji
authors: K
authors: Uchino
authors: Ryosuke
authors: R
authors: Tateishi
authors: Hayato
authors: H
authors: Nakagawa
authors: Junichi
authors: J
authors: Shindoh
authors: Yasuhiko
authors: Y
authors: Sugawara
authors: Masaaki
authors: M
authors: Akahane
authors: Junji
authors: J
authors: Shibahara
authors: Haruhiko
authors: H
authors: Yoshida
authors: Kazuhiko
authors: K
authors: Koike
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging / Q000473:pathology; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D060085:Coinfection; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications* / Q000821:virology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D014463:Ultrasonography