title: Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo.
abstract: Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer) while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Daniel J
authors: DJ
authors: Coles
authors: Barbara E
authors: BE
authors: Rolfe
authors: Nathan R B
authors: NR
authors: Boase
authors: Rakesh N
authors: RN
authors: Veedu
authors: Kristofer J
authors: KJ
authors: Thurecht
mesh_terms: D000818:Animals; D052158:Aptamers, Peptide / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008546:Melanoma, Experimental / Q000473:pathology*; D008689:Methacrylates / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D057054:Molecular Imaging / Q000379:methods; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D012235:Rhodamines; D012878:Skin Neoplasms / Q000473:pathology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D052158:Aptamers, Peptide; D005456:Fluorescent Dyes; D008689:Methacrylates; D012235:Rhodamines; C524499:polyethylene glycol methacrylate; D011092:Polyethylene Glycols; C029773:rhodamine B