title: Impact of physical parameters on particle size and reaction yield when using the ionic gelation method to obtain cationic polymeric chitosan-tripolyphosphate nanoparticles.
abstract: Ionic gelation is the most frequently used method to obtain chitosan-tripolyphosphate nanoparticles due to its simplicity and because it does not generate waste solvents in the samples prepared. This paper presents a study of the physical factors involved in this method for obtaining nanoparticles in order to determine which of them significantly influences the particle size of polymeric nanoparticles made from low-molecular-weight chitosan, without any additional chemical treatment, with the aim of standardising and optimising the method conditions, in addition to establishing the reaction yield. The results indicate that stirring speed during ionic gelation reaction is decisive for the size of the nanoparticles obtained. Furthermore, it thus follows that the stirring speed during ionic gelation significantly affects reaction yield, and therefore, by manipulating this parameter a greater proportion of nanoparticles of a given size range can be obtained.
authors: Service of Development of Medicines (SDM), Faculty of Pharmacy, University of Barcelona, Avda. Joan XXIII, s/n 08028 Barcelona, Spain. afabregas@ub.edu
authors: A
authors: A
authors: Fàbregas
authors: M
authors: M
authors: Miñarro
authors: E
authors: E
authors: García-Montoya
authors: P
authors: P
authors: Pérez-Lozano
authors: C
authors: C
authors: Carrillo
authors: R
authors: R
authors: Sarrate
authors: N
authors: N
authors: Sánchez
authors: J R
authors: JR
authors: Ticó
authors: J M
authors: JM
authors: Suñé-Negre
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D005782:Gels; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011122:Polyphosphates / Q000737:chemistry*
chemical_list: D005782:Gels; D011122:Polyphosphates; D048271:Chitosan; C005692:triphosphoric acid