title: Multifunctional core-shell-corona-type polymeric micelles for anticancer drug-delivery and imaging.
abstract: We have developed core-shell-corona-type polymeric micelles that can integrate multiple functions in one system, including the capability of accommodating hydrophobic dyes into core and hydrophilic drug into the shell, as well as pH-triggered drug-release. The neutral and hydrophilic corona sterically stabilizes the multifunctional polymeric micelles in aqueous solution. The mineralization of calcium phosphate (CaP) on the PAA domain not only enhances the diagnostic efficacy of organic dyes, but also works as a diffusion barrier for the controlled release.
authors: World Premier International (WPI), Research Center for Materials, Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors: Bishnu Prasad
authors: BP
authors: Bastakoti
authors: Kevin C-W
authors: KC
authors: Wu
authors: Masamichi
authors: M
authors: Inoue
authors: Shin-ichi
authors: S
authors: Yusa
authors: Kenichi
authors: K
authors: Nakashima
authors: Yusuke
authors: Y
authors: Yamauchi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002130:Calcium Phosphates / Q000737:chemistry; D002945:Cisplatin / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D002130:Calcium Phosphates; D008823:Micelles; D011108:Polymers; D002945:Cisplatin