title: Central nervous system drug evaluation using positron emission tomography.
abstract: In conventional pharmacological research in the field of mental disorders, pharmacological effect and dose have been estimated by ethological approach and in vitro data of affinity to the site of action. In addition, the frequency of administration has been estimated from drug kinetics in blood. However, there is a problem regarding an objective index of drug effects in the living body. Furthermore, the possibility that the concentration of drug in blood does not necessarily reflect the drug kinetics in target organs has been pointed out. Positron emission tomography (PET) techniques have made progress for more than 20 years, and made it possible to measure the distribution and kinetics of small molecule components in living brain. In this article, we focused on rational drug dosing using receptor occupancy and proof-of-concept of drugs in the drug development process using PET.
authors: Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan. ; Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan.
authors: Mizuho
authors: M
authors: Sekine
authors: Jun
authors: J
authors: Maeda
authors: Hitoshi
authors: H
authors: Shimada
authors: Tsuyoshi
authors: T
authors: Nogami
authors: Ryosuke
authors: R
authors: Arakawa
authors: Harumasa
authors: H
authors: Takano
authors: Makoto
authors: M
authors: Higuchi
authors: Hiroshi
authors: H
authors: Ito
authors: Yoshiro
authors: Y
authors: Okubo
authors: Tetsuya
authors: T
authors: Suhara
keywords: Dopamine D receptor; Norepinephrine transporter; Occupancy; Positron emission tomography; Serotonin transporter; micro-PET