title: [Functional changes in human peripheral neutrophils in workers with different exposure to noxious agents].
abstract: Free radicals have a role in interaction between occupational exposure to multiple agents and biological systems; peripheral neutrophils (PMNs) are a source of free radicals and other reactive oxygen species. PMN's activity was evaluated by chemiluminescence assays referring to different noxious agents exposure levels. Two office workers groups were recruited: first one was exposed to several agents, control group was composed by lower exposure workers. Intra and extracellular chemiluminescence evaluation was performed to obtain radical species information. Stimulated PMNs from exposed subjects respond to the stimuli less than unexposed, and can be suggested as chronic exposure markers to noxious agents.
authors: Dipartimento di Medicina Sperimentale - Sezione di Igiene, Medicina del Lavoro e Medicina Legale- Area di Medicina del Lavoro - Seconda Università degli Studi di Napoli, Italy. elpidio.garzillo@libero.it
authors: E M
authors: EM
authors: Garzillo
authors: D
authors: D
authors: Feola
authors: P
authors: P
authors: Pedata
authors: M
authors: M
authors: Lamberti
authors: N
authors: N
authors: Sannolo
authors: F
authors: F
authors: D'Ancicco
authors: N
authors: N
authors: Miraglia
mesh_terms: D015386:Hazardous Substances / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D016273:Occupational Exposure
chemical_list: D015386:Hazardous Substances