title: Exosomes: looking back three decades and into the future.
abstract: Exosomes are extracellular membrane vesicles whose biogenesis by exocytosis of multivesicular endosomes was discovered in 1983. Since their discovery 30 years ago, it has become clear that exosomes contribute to many aspects of physiology and disease, including intercellular communication. We discuss the initial experiments that led to the discovery of exosomes and highlight some of the exciting current directions in the field.
authors: Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, USA.
authors: Clifford V
authors: CV
authors: Harding
authors: John E
authors: JE
authors: Heuser
authors: Philip D
authors: PD
authors: Stahl
mesh_terms: D016764:Cell Polarity / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology*; D008954:Models, Biological; D012440:Saccharomyces / Q000166:cytology*