title: Maxillary growth in a congenital cleft palate canine model for surgical research.
abstract: We have recently presented the Old Spanish Pointer dog, with a 15-20% spontaneous congenital cleft palate rate, as a unique experimental model of this disease. This study aimed to describe the cleft palate of these dogs for surgical research purposes and to determine whether congenital cleft palate influences maxillofacial growth. Seven newborn Old Spanish Pointer dogs of both sexes, comprising a cleft palate group (n = 4) and a normal palate group (n = 3), were fed using the same technique. Macroscopic photographs and plaster casts from the palate, lateral radiographs and computer tomograms of the skull were taken sequentially over 41 weeks, starting at week 5. The cleft morphology, the size and the tissue characteristics in these dogs resembled the human cleft better than current available animal models. During growth, the cleft width varies. Most of the transverse and longitudinal measures of the palate were statistically lower in the cleft palate group. The cleft palate group showed hypoplasia of the naso-maxillary complex. This model of congenital cleft palate seems suitable for surgical research purposes. A reduced maxillofacial pre- and post-natal development is associated to the congenital cleft palate in the Old Spanish Pointer dog.
authors: Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Facultad de Odontología, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain.
authors: Irene
authors: I
authors: Paradas-Lara
authors: Departamento de Estomatología IV, Facultad de Odontología, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain.
authors: Inmaculada
authors: I
authors: Casado-Gómez
authors: Departamento de Estomatología IV, Facultad de Odontología, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain.
authors: Conchita
authors: C
authors: Martín
authors: Servicio Aragonés de Salud, Atención Primaria, Sector Zaragoza III, 50500 Tarazona, Spain.
authors: Elena
authors: E
authors: Martínez-Sanz
authors: Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Facultad de Odontología, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain.
authors: Yamila
authors: Y
authors: López-Gordillo
authors: Departamento de Medicina y Cirugía Experimentales, Hospital Universitario Clínico San Carlos, Profesor Martín Lago s/n, 28040 Madrid, Spain.
authors: Pablo
authors: P
authors: González
authors: Departamento de Medicina y Cirugía Experimentales, Hospital Universitario Clínico San Carlos, Profesor Martín Lago s/n, 28040 Madrid, Spain.
authors: Cruz
authors: C
authors: Rodríguez-Bobada
authors: Policlínica Veterinaria, Centro Militar de Veterinaria, Ministerio de la Defensa de España, Darío Gazapo 3, 28024 Madrid, Spain.
authors: Manuel
authors: M
authors: Chamorro
authors: Policlínica Veterinaria, Centro Militar de Veterinaria, Ministerio de la Defensa de España, Darío Gazapo 3, 28024 Madrid, Spain.
authors: Pablo
authors: P
authors: Arias
authors: Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Facultad de Odontología, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain.
authors: Estela
authors: E
authors: Maldonado
authors: Departamento de Estomatología III, Facultad de Odontología, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain.
authors: Ricardo
authors: R
authors: Ortega
authors: Servicio de Cirugía Plástica Infantil, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Beatriz
authors: B
authors: Berenguer
authors: Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Facultad de Odontología, Universidad Complutense de Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain. Electronic address: cmartinez@med.ucm.es.
authors: Concepción
authors: C
authors: Martínez-Álvarez
mesh_terms: D059925:Anatomic Landmarks / Q000254:growth & development / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D002508:Cephalometry / Q000379:methods; D002972:Cleft Palate / Q000503:physiopathology / Q000601:surgery*; D003724:Dental Arch / Q000254:growth & development / Q000473:pathology; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008334:Mandible / Q000473:pathology; D008437:Maxilla / Q000254:growth & development* / Q000473:pathology; D008445:Maxillofacial Development / Q000502:physiology; D003765:Models, Dental; D009295:Nasal Bone / Q000473:pathology; D009666:Nose / Q000002:abnormalities; D010159:Palate / Q000000981:diagnostic imaging / Q000254:growth & development / Q000473:pathology; D010781:Photography; D013997:Time Factors; D036542:Tomography, Spiral Computed / Q000379:methods
keywords: Congenital cleft palate; Dog; Maxillofacial growth; Surgical research