title: Treatment-related changes in serum lipids and inflammation: clinical relevance remains unclear. Analyses from the Women's Interagency HIV study.
abstract: Among 127 HIV-infected women, the magnitude of high-density lipoprotein cholesterol (HDLc) increases after HAART initiation predicted the magnitude of concurrent decreases in inflammation biomarkers. After HAART initiation, changes in low-density lipoprotein cholesterol (LDLc) and inflammation were unrelated. In the same population, predicted risk of coronary heart disease, based upon levels of standard clinical risk factors, was similar before and after HAART. Thus, it remains unknown whether short-term treatment-related changes in standard risk factors may appreciably change risk of cardiovascular disease (CVD).
authors: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
authors: Christina M
authors: CM
authors: Parrinello
authors: Alan L
authors: AL
authors: Landay
authors: Howard N
authors: HN
authors: Hodis
authors: Stephen J
authors: SJ
authors: Gange
authors: Philip J
authors: PJ
authors: Norris
authors: Mary
authors: M
authors: Young
authors: Kathryn
authors: K
authors: Anastos
authors: Phyllis C
authors: PC
authors: Tien
authors: Xiaonan
authors: X
authors: Xue
authors: Jason
authors: J
authors: Lazar
authors: Lorie
authors: L
authors: Benning
authors: Russell P
authors: RP
authors: Tracy
authors: Robert C
authors: RC
authors: Kaplan
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D012307:Risk Factors; D016387:Women's Health
chemical_list: D008076:Cholesterol, HDL