title: Recurrent adult choroid plexus carcinoma treated with high-dose chemotherapy and syngeneic stem cell (bone marrow) transplant.
abstract: Choroid plexus carcinomas (CPCs) are rare epithelial central nervous system tumors. CPC occurs mainly in infants and young children, comprising ≈ 1 to 4% of all pediatric brain neoplasms. There is very limited information available regarding tumor biology and CPC treatment due to its rarity. There have been various case reports and meta-analyses of reported cases with CPC. Surgical resection is often challenging but remains a well-established treatment option. Chemotherapy is often reserved for recurrent or refractory cases, but the goal of treatment is usually palliative. We present a case of recurrent, adult CPC with disseminated leptomeningeal involvement treated with salvage chemotherapy including high-dose ifosfamide, carboplatin, and etoposide; once a remission was achieved, this response was consolidated with a syngeneic stem cell (bone marrow) transplant after a preparative regimen of high-dose chemotherapy with carboplatin, etoposide, and thiotepa. Although the patient tolerated the transplant well and remained disease-free for 12 months, she subsequently succumbed to relapsed disease 18 months posttransplant. We believe that this is the first report of using syngeneic stem cell transplant in CPC to consolidate a remission achieved by salvage chemotherapy.
authors: Department of Medicine, Hematology/Oncology, Georgia Health Sciences University, Augusta, Georgia, United States.
authors: Thomas A
authors: TA
authors: Samuel
authors: Department of Medicine, Georgia Health Sciences University, Augusta, Georgia, United States.
authors: Jigarkumar
authors: J
authors: Parikh
authors: Department of Pathology, Georgia Health Sciences University, Augusta, Georgia, United States.
authors: Suash
authors: S
authors: Sharma
authors: Department of Neurosurgery, Georgia Health Sciences University, Augusta, Georgia, United States.
authors: Cole A
authors: CA
authors: Giller
authors: Department of Medicine, Georgia Health Sciences University, Augusta, Georgia, United States.
authors: Kristen
authors: K
authors: Sterling
authors: Department of Medicine, Georgia Health Sciences University, Augusta, Georgia, United States.
authors: Suraj
authors: S
authors: Kapoor
authors: Department of Medicine, Georgia Health Sciences University, Augusta, Georgia, United States.
authors: Christen
authors: C
authors: Pirkle
authors: Department of Medicine, Georgia Health Sciences University, Augusta, Georgia, United States.
authors: Anand
authors: A
authors: Jillella
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation / Q000379:methods*; D002277:Carcinoma / Q000628:therapy*; D002528:Cerebellar Neoplasms / Q000473:pathology; D002530:Cerebellopontine Angle / Q000473:pathology; D059248:Chemoradiotherapy; D016545:Choroid Plexus Neoplasms / Q000628:therapy*; D018572:Disease-Free Survival; D017809:Fatal Outcome; D005260:Female; D034381:Hearing Loss / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009464:Neuroma, Acoustic / Q000473:pathology; D010166:Palliative Care; D012640:Seizures / Q000209:etiology; D033581:Stem Cell Transplantation / Q000379:methods*; D014185:Transplantation, Isogeneic / Q000379:methods*; D014427:Twins; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents