title: A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies.
abstract: We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA "zigzag" channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.
authors: Tecnológico de Monterrey at Monterrey, Centro de Biotecnología-FEMSA, Ave. Eugenio Garza-Sada 2501, Monterrey, N.L., México.
authors: Lucía D
authors: LD
authors: Garza-García
authors: Leydi M
authors: LM
authors: Carrillo-Cocom
authors: Diana
authors: D
authors: Araiz-Hernández
authors: Pedro
authors: P
authors: Soto-Vázquez
authors: Julián
authors: J
authors: López-Meza
authors: Eduardo J
authors: EJ
authors: Tapia-Mejía
authors: Sergio
authors: S
authors: Camacho-León
authors: Erika
authors: E
authors: García-López
authors: Ciro A
authors: CA
authors: Rodríguez-González
authors: Mario M
authors: MM
authors: Alvarez
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D056656:Lab-On-A-Chip Devices; D019904:Polymethyl Methacrylate / Q000737:chemistry*
chemical_list: D000911:Antibodies, Monoclonal; D019904:Polymethyl Methacrylate