title: Radiolabeled nanogels for nuclear molecular imaging.
abstract: An efficient and simple synthesis approach to form stable (68) Ga-labeled nanogels is reported and their fundamental properties investigated. Nanogels are obtained by self-assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting nanogels exhibit a well-defined spherical shape with a diameter of 290 ± 50 nm. The radionuclide (68) Ga is chelated in high radiochemical yields in an aqueous medium at room temperature. The phagocytosis assay demonstrates a highly increased internalization of nanogels by activated macrophages. Access to these (68) Ga-nanogels will allow the investigation of general behavior and clearance pathways of nanogels in vivo by nuclear molecular imaging.
authors: Interactive Materials Research-DWI an der RWTH Aachen e.V. and Institute Technical and Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstr. 50, 52074 Aachen, Germany.
authors: Smriti
authors: S
authors: Singh
authors: Bahar
authors: B
authors: Bingöl
authors: Agnieszka
authors: A
authors: Morgenroth
authors: Felix M
authors: FM
authors: Mottaghy
authors: Martin
authors: M
authors: Möller
authors: Jörn
authors: J
authors: Schmaljohann
mesh_terms: D005710:Gallium Radioisotopes / Q000737:chemistry; D006801:Humans; D007553:Isotope Labeling; D008264:Macrophages / Q000737:chemistry; D057054:Molecular Imaging / Q000295:instrumentation*; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011094:Polyethyleneimine / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D005710:Gallium Radioisotopes; D000080385:Nanogels; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine