title: Polymorphism and solvates of flecainide base.
abstract: Flecainide base is pharmaceutically active substance used for production of flecainide acetate which is known in market as Tambacor, Almarytm, Apocard, Ecrinal or Flecaine. It is determined that flecainide base forms four polymorphic forms abbreviated as Ib, IIb, IIIb and IVb. Flecainide base form Ib is thermodynamically stable form at laboratory temperature while form IIIb is stable at higher temperatures. Flecainide form Ib absorbs water in its structure between layers and forms non-stoichiometric hydrate. Flecainide base binds with organic solvents and form monosolvates. Flecainide base form Ib crystallizes in orthorhombic crystals with lattice parameters a = 27.88 Å, b = 13.78 Å, c = 9.98 Å and two independent molecules in unit cell (Z' = 2; Z = 8). Molecule arrangement in flecainide base form Ib structure is not dense and it forms a channel-type structure, where molecules of water and alcohols are placed.
authors: Department of Chemistry, University of Latvia , Riga , Latvia and.
authors: K
authors: K
authors: Veldre
authors: Z
authors: Z
authors: Eglīte
authors: A
authors: A
authors: Actiņš
authors: A
authors: A
authors: Zvirgzdiņš
authors: L
authors: L
authors: Rozenberga
authors: E
authors: E
authors: Tamanis
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000737:chemistry*; D003460:Crystallization; D005424:Flecainide / Q000737:chemistry*; D013816:Thermodynamics; D061567:Voltage-Gated Sodium Channel Blockers / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D000889:Anti-Arrhythmia Agents; D061567:Voltage-Gated Sodium Channel Blockers; D014867:Water; D005424:Flecainide