title: [Effect of stellate ganglion block on reconstruction of the left ventricle in spontaneously hypertensive rats].
abstract: OBJECTIVE
  To determine the effect of stellate ganglion block on reconstruction of the left ventricle in spontaneously hypertensive rats (SHRs).
  
  
  METHODS
  Thirty-two 10-week-old male SHRs were randomly assigned into 4 groups: a left stellate ganglion block group (group LS), a right stellate ganglion block group (group RS), a captopril group (group D) and a control group (group C). The arterial systolic blood pressure (SBP) was measured by ALC-NIBP measuring system. After 10 weeks, we observed the left ventricular mass index (LVMI), myocardial pathologic changes, and detected the endothelin (ET-1) and endothelial nitric oxide synthase (eNOS) level in the left ventricle by radioimmunoassay and the collagen protein level in the left ventricle by immunohistochemical method.
  
  
  RESULTS
  Compared with group LS and group C, the LVMI in group RS was lowered most notably (P<0.05) and pathological changes were improved obviously. The expression of eNOS in group RS was significantly increased and ET-1 significantly decreased (P<0.05) compared with that in group C and group LS. The expression of type I collagen fibers in group RS was significantly lower and type III collagen fibers significantly higher (P<0.05) when compared with that in group C and LS.
  
  
  CONCLUSIONS
  Right stellate ganglion block can not only decrease the arterial pressure but also reverse the reconstruction of the left ventricle.
authors: Department of Anesthesiology, Affiliated Hospital, Wannan Medical College, Wuhu Anhui 241001, China. chenyq263@163.com
authors: Yongquan
authors: Y
authors: Chen
authors: Guangxiang
authors: G
authors: Hu
authors: Qun
authors: Q
authors: Fu
authors: Xiaoju
authors: X
authors: Jin
mesh_terms: D000818:Animals; D001340:Autonomic Nerve Block; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D013233:Stellate Ganglion; D020257:Ventricular Remodeling / Q000502:physiology*