title: Transient receptor potential (TRP) cation channels in diabetes.
abstract: Transient Receptor Potential (TRP) proteins constitute a family of cation channels with very diverse permeation and gating properties. Likewise they have a very diverse role in mammalian physiology ranging from sensory nerve endings, the cardiac muscle to immune cells. Increasing evidence has implicated TRP channels in the pathology of diabetes, both on the level of insulin release from the pancreatic ß cells and in secondary conditions such as diabetic neuropathy, nephropathy and vasculopathy. In this review we summarize these recent findings, which all together indicate that TRP channels are interesting drug targets for the treatment of patients suffering from diabetes.
authors: KU Leuven, Department of Molecular and Cellular Medicine, Laboratory of Ion Channel Research, Campus Gasthuisberg, Herestraat 49, bus 802, B-3000 Leuven, Belgium. rudi.vennekens@med.kuleuven.be
authors: Barbara
authors: B
authors: Colsoul
authors: Bernd
authors: B
authors: Nilius
authors: Rudi
authors: R
authors: Vennekens
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D058990:Molecular Targeted Therapy; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D007328:Insulin; D050051:Transient Receptor Potential Channels