title: Pharmacokinetic characteristics of capsaicin-loaded nanoemulsions fabricated with alginate and chitosan.
abstract: Nanotechnologies are being employed to enhance the stability and oral bioavailability of lipophilic substances, such as capsaicin. This study aimed to examine the pharmacokinetic properties of the formulated capsaicin-loaded nanoemulsions. A pharmacokinetic study was carried out using double-layer nanoemulsions fabricated with alginate and chitosan polymers and triple-layer nanoemulsions fabricated with chitosan/alginate polymers. Capsaicin nanoemulsions and capsaicin control (oleoresin capsicum) were administered to the rat at a dose of 10 mg/kg. A statistically significant difference was found in the area under the curve from time zero to time infinity (AUCinf) among formulations (p < 0.01). In comparison to the control group, the relative bioavailability of formulated nanoemulsions was up to 131.7. The AUCinf increased in a nano-size-dependent manner; as nano size decreased, AUCinf increased. IN comparison to the double-layer nanoemulsions, the triple-layer nanoemulsion showed a significantly increased volume of distribution, resulting in the increased clearance and decreased AUCinf. It was concluded that the formulated nanoemulsions could significantly enhance the bioavailabilty of capsaicin.
authors: College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University , 52 Ewhayeodae-gil Seodaemun-gu, Seoul 120-750, Korea.
authors: Ah Young
authors: AY
authors: Choi
authors: Chong-Tai
authors: CT
authors: Kim
authors: Hee Yoon
authors: HY
authors: Park
authors: Han Oll
authors: HO
authors: Kim
authors: Na Ra
authors: NR
authors: Lee
authors: Kyung Eun
authors: KE
authors: Lee
authors: Hye Sun
authors: HS
authors: Gwak
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D001682:Biological Availability; D002211:Capsaicin / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D048271:Chitosan / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry / Q000493:pharmacokinetics*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008297:Male; D049329:Nanostructures; D036103:Nanotechnology; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000464:Alginates; D004655:Emulsions; D006603:Hexuronic Acids; D011108:Polymers; D020723:Glucuronic Acid; D048271:Chitosan; D002211:Capsaicin