title: Primary progressive multiple sclerosis: progress and challenges.
abstract: Primary progressive multiple sclerosis (MS) has long been recognised as presenting great difficulties to our management of what is increasingly a treatable neurological disease. Here we review some basic and clinical aspects of primary progressive MS, and describe how the disorder in fact offers powerful insights and opportunities for better understanding multiple sclerosis, and from a practical perspective an invaluable clinical substrate for studying and treating progressive disability in MS. Difficult hurdles remain, however, and these too are reviewed.
authors: University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK.
authors: Claire M
authors: CM
authors: Rice
authors: David
authors: D
authors: Cottrell
authors: Alastair
authors: A
authors: Wilkins
authors: Neil J
authors: NJ
authors: Scolding
mesh_terms: D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D004185:Disability Evaluation; D005544:Forecasting; D006801:Humans; D008279:Magnetic Resonance Imaging; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D009414:Nerve Growth Factors / Q000627:therapeutic use; D011237:Predictive Value of Tests; D011379:Prognosis; D033581:Stem Cell Transplantation
chemical_list: D009414:Nerve Growth Factors
keywords: Multiple Sclerosis