title: Effect of surfactant and partial liquid ventilation treatment on gas exchange and lung mechanics in immature lambs: influence of gestational age.
abstract: OBJECTIVE
  Surfactant (SF) and partial liquid ventilation (PLV) improve gas exchange and lung mechanics in neonatal RDS. However, variations in the effects of SF and PLV with degree of lung immaturity have not been thoroughly explored.
  
  
  METHODS
  Experimental Neonatal Respiratory Physiology Research Unit, Cruces University Hospital.
  
  
  METHODS
  Prospective, randomized study using sealed envelopes.
  
  
  METHODS
  36 preterm lambs were exposed (at 125 or 133-days of gestational age) by laparotomy and intubated. Catheters were placed in the jugular vein and carotid artery.
  
  
  METHODS
  All the lambs were assigned to one of three subgroups given: 20 mL/Kg perfluorocarbon and managed with partial liquid ventilation (PLV), surfactant (Curosurf®, 200 mg/kg) or (3) no pulmonary treatment (Controls) for 3 h.
  
  
  RESULTS
  Cardiovascular parameters, blood gases and pulmonary mechanics were measured. In 125-day gestation lambs, SF treatment partially improved gas exchange and lung mechanics, while PLV produced significant rapid improvements in these parameters. In 133-day lambs, treatments with SF or PLV achieved similarly good responses. Neither surfactant nor PLV significantly affected the cardiovascular parameters.
  
  
  CONCLUSIONS
  SF therapy response was more effective in the older gestational age group whereas the effectiveness of PLV therapy was not gestational age dependent.
authors: Research Unit for Experimental Neonatal Respiratory Physiology, Cruces University Hospital, Barakaldo, Bizkaia, Spain. macarmen.reysantano@osakidetza.net
authors: Carmen
authors: C
authors: Rey-Santano
authors: Victoria
authors: V
authors: Mielgo
authors: Elena
authors: E
authors: Gastiasoro
authors: Adolfo
authors: A
authors: Valls-i-Soler
authors: Xabier
authors: X
authors: Murgia
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage / Q000494:pharmacology*; D005865:Gestational Age; D006439:Hemodynamics / Q000187:drug effects; D021061:Liquid Ventilation / Q000379:methods*; D008297:Male; D011247:Pregnancy; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000503:physiopathology / Q000628:therapy; D015656:Respiratory Mechanics / Q000187:drug effects*; D012756:Sheep; D016896:Treatment Outcome
chemical_list: D005466:Fluorocarbons; D011663:Pulmonary Surfactants