title: A comparative study of axon-surrounding cells in the two nasal nerve tracts from mouse olfactory epithelium and vomeronasal organ.
abstract: The olfactory and vomeronasal systems are the two nasal chemical detectors in mammals. While glial cells in the olfactory nerve tracts have been well-investigated, little is known about cells in the vomeronasal nerve tracts. In the present study, we compared the expression patterns of marker proteins in the cells comprising the two nasal nerve tracts in mice. Neural crest-derived cells surrounded the olfactory nerve axons in the lamina propria of the olfactory epithelium. These cells expressed glial fibrillary acidic protein (GFAP) and p75 glycoprotein, which are markers of olfactory ensheathing cells. Neural crest-derived cells also surrounded the vomeronasal nerve axons in the lamina propria of the vomeronasal epithelium. These nerve axon-surrounding cells, however, did not express GFAP or p75. Rather, the vomeronasal nerve axons expressed GFAP and p75. These results suggest that axon-surrounding cells functionally differ between the olfactory and vomeronasal nerve tracts.
authors: Department of Pharmaceutical Pharmacology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama 790-8578, Ehime, Japan. mnakajim@cc.matsuyama-u.ac.jp
authors: Mitsunari
authors: M
authors: Nakajima
authors: Momoko
authors: M
authors: Tsuruta
authors: Hisamichi
authors: H
authors: Mori
authors: Chisa
authors: C
authors: Nishikawa
authors: Satoshi
authors: S
authors: Okuyama
authors: Yoshiko
authors: Y
authors: Furukawa
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000502:physiology*; D004622:Embryo, Mammalian; D019922:GAP-43 Protein / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D009831:Olfactory Mucosa / Q000166:cytology*; D009833:Olfactory Pathways / Q000502:physiology*; D011506:Proteins / Q000235:genetics; D022661:RNA, Untranslated; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism; D011984:Sensory Receptor Cells / Q000166:cytology* / Q000378:metabolism; D019147:Vomeronasal Organ / Q000166:cytology*; D051155:Wnt1 Protein / Q000235:genetics; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: D019922:GAP-43 Protein; D005904:Glial Fibrillary Acidic Protein; C110853:Gt(ROSA)26Sor non-coding RNA, mouse; D011506:Proteins; D022661:RNA, Untranslated; D020800:Receptor, Nerve Growth Factor; D051155:Wnt1 Protein; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; D001616:beta-Galactosidase