title: Lichenic extracts and metabolites as UV filters.
abstract: Three lichen extracts and ten lichenic compounds have been screened for their photoprotective activities. The determination of their Sun Protection Factor (SPF) and Protection Factor-UVA (PF-UVA) values was done in vitro. Among them, a Lasallia pustulata extract and gyrophoric acid exhibited SPF values over 5, which is better than Homosalate (SPF≈4). Their photoprotective properties are only slightly modified after a 2-hours period of irradiation. Salazinic acid and L. pustulata presented characteristics of a UVA booster like the butyl-methoxydibenzoylmethane (Avobenzone) (PF-UVA≈2 vs. 2.8 for Avobenzone). Salazinic acid was a better anion superoxide scavenger than ascorbic acid and none of them exhibited a photosensitizing cytotoxicity by exposing them on HaCaT cells to UVA radiations (photo-irritancy factor PIF<5).
authors: PNSCM-UMR 6226; Faculté des Sciences Pharmaceutiques et Biologiques, Université Européenne de Bretagne, Université de Rennes 1, 2 Av. du Pr Léon Bernard, 35043 Rennes Cedex, France. francoise.le-devehat@univ-rennes1.fr
authors: Françoise
authors: F
authors: Lohézic-Le Dévéhat
authors: Béatrice
authors: B
authors: Legouin
authors: Céline
authors: C
authors: Couteau
authors: Joël
authors: J
authors: Boustie
authors: Laurence
authors: L
authors: Coiffard
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D001203:Ascomycota / Q000737:chemistry / Q000378:metabolism; D001565:Benzoates / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D001572:Benzofurans / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D005650:Fumarates / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D007783:Lactones / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D012459:Salicylates / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D059405:Sun Protection Factor / Q000379:methods*; D014466:Ultraviolet Rays; D020949:Usnea / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D001565:Benzoates; D001572:Benzofurans; D005650:Fumarates; D007783:Lactones; D012459:Salicylates; C116675:salazinic acid; C073339:usnic acid; C026307:fumarprotocetraric acid; C120727:gyrophoric acid