title: Molecular epidemiology of human metapneumovirus from 2005 to 2011 in Fukui, Japan.
abstract: To investigate the molecular epidemiology of human metapneumovirus (HMPV) infections in acute respiratory infections (ARI), we performed genetic analysis of the F gene in HMPV from patients with ARI in Fukui Prefecture from August 2005 to July 2011. HMPV was detected in 53 of 741 nasopharyngeal swabs (7.2%). Phylogenetic analysis helped us assign 31 strains to subgroup A2, 1 strain to subgroup B1, and 21 strains to subgroup B2. The prevalence of HMPV was peaked between January and June. A high degree of nucleotide identity was seen among subgroup A2 strains (95.6-100%) and subgroup B2 strains (97.5-100%). In addition, no positively selected sites (substitutions) were found in the F gene in these HMPV strains. The results suggest that the prevalent HMPV strains in Fukui were associated with various ARI in Japan during the investigation period.
authors: Fukui Prefectural Institute of Public Health and Environmental Science, Fukui 910-8551, Japan.
authors: Masako
authors: M
authors: Nakamura
authors: Eiko
authors: E
authors: Hirano
authors: Fubito
authors: F
authors: Ishiguro
authors: Katsumi
authors: K
authors: Mizuta
authors: Masahiro
authors: M
authors: Noda
authors: Ryota
authors: R
authors: Tanaka
authors: Hiroyuki
authors: H
authors: Tsukagoshi
authors: Hirokazu
authors: H
authors: Kimura
mesh_terms: D000208:Acute Disease; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D029121:Metapneumovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D008875:Middle Aged; D017720:Molecular Epidemiology; D009305:Nasopharynx / Q000821:virology*; D018184:Paramyxoviridae Infections / Q000453:epidemiology* / Q000821:virology; D010802:Phylogeny; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000821:virology; D012621:Seasons; D014764:Viral Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D014764:Viral Proteins