title: Prevalence and risk factors of nasopharyngeal carriage of Streptococcus pneumoniae in healthy children in Japan.
abstract: The findings of this study revealed a 22% prevalence of Streptococcus pneumoniae among healthy children in Japan; the prevalence tended to increase with age. We identified attendance at day-care facilities and the presence of older siblings as the major risk factors associated with pneumococcal carriage. A significant decrease in pneumococcal colonization was observed among children during the summer; however, a seasonal variation was independent of various factors. Our findings suggest that prior immunization with heptavalent pneumococcal conjugate vaccine within the current recommended schedule is required for children exposed to these risk factors.
authors: Department of Pediatrics, Hasuda Issinkai Hospital, Saitama 349-0123, Japan. m10d026u@oc.toho-u.ac.jp
authors: Masahiro
authors: M
authors: Ueno
authors: Yoshikazu
authors: Y
authors: Ishii
authors: Kazuhiro
authors: K
authors: Tateda
authors: Yoshiko
authors: Y
authors: Anahara
authors: Akiko
authors: A
authors: Ebata
authors: Masaei
authors: M
authors: Iida
authors: Seiko
authors: S
authors: Inamura
authors: Kahori
authors: K
authors: Takahata
authors: Yoko
authors: Y
authors: Suzuki
authors: Bin
authors: B
authors: Chang
authors: Akihito
authors: A
authors: Wada
authors: Minoru
authors: M
authors: Sugita
authors: Taichiro
authors: T
authors: Tanaka
authors: Yuji
authors: Y
authors: Nishiwaki
mesh_terms: D000367:Age Factors; D002353:Carrier State / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D002648:Child; D002656:Child Day Care Centers; D002675:Child, Preschool; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D009305:Nasopharynx / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology*; D015995:Prevalence; D012307:Risk Factors; D012621:Seasons; D035781:Siblings; D013296:Streptococcus pneumoniae / Q000276:immunology / Q000302:isolation & purification*; D011795:Surveys and Questionnaires; D014611:Vaccination
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines