title: mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
abstract: Oligodendrocyte development is controlled by numerous extracellular signals that regulate a series of transcription factors that promote the differentiation of oligodendrocyte progenitor cells to myelinating cells in the central nervous system. A major element of this regulatory system that has only recently been studied is the intracellular signalling from surface receptors to transcription factors to down-regulate inhibitors and up-regulate inducers of oligodendrocyte differentiation and myelination. The current review focuses on one such pathway: the mTOR (mammalian target of rapamycin) pathway, which integrates signals in many cell systems and induces cell responses including cell proliferation and cell differentiation. This review describes the known functions of mTOR as they relate to oligodendrocyte development, and its recently discovered impact on oligodendrocyte differentiation and myelination. A potential model for its role in oligodendrocyte development is proposed.
authors: Department of Neurology and Neuroscience, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA.
authors: Teresa L
authors: TL
authors: Wood
authors: Kathryn K
authors: KK
authors: Bercury
authors: Stacey E
authors: SE
authors: Cifelli
authors: Lauren E
authors: LE
authors: Mursch
authors: Jungsoo
authors: J
authors: Min
authors: Jinxiang
authors: J
authors: Dai
authors: Wendy B
authors: WB
authors: Macklin
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009420:Nervous System / Q000166:cytology* / Q000254:growth & development; D009836:Oligodendroglia / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases