title: Development of 'leaky' liposome triggered by radiation applicable to a drug reservoir and a simple radiation dosimeter.
abstract: Radiation effects on permeability of liposomes with different lipid compositions and the content ratios were investigated using X-rays. Liposomes constituted from an unsaturated phosphatidylcholine (PC), a saturated PC, and cholesterol were selected. As a result, we found that a PC with bis-allylic hydrogen, particularly dilinoleoyl PC (DLOPC), is essential for the radiation sensitivity in permeability, and it can be controlled by changing DLOPC content and dose rate. These characteristics are contributive to a novel pharmaceutical and a new-conceptual radiation dosimeter.
authors: Nuclear Science and Engineering Directorate, Radiation Effect Analysis Group, Japan Atomic Energy Agency, 2-4 Shirakatashirane, Tokai-mura, Naka-gun, Ibaraki, Japan. akamatsu.ken@jaea.go.jp
authors: Ken
authors: K
authors: Akamatsu
mesh_terms: D016503:Drug Delivery Systems; D008081:Liposomes / Q000737:chemistry / Q000528:radiation effects*; D015394:Molecular Structure; D010539:Permeability / Q000528:radiation effects; D010713:Phosphatidylcholines / Q000737:chemistry / Q000528:radiation effects; D011874:Radiometry / Q000295:instrumentation*
chemical_list: D008081:Liposomes; D010713:Phosphatidylcholines; C002448:1,2-linoleoylphosphatidylcholine