title: Xerosis is associated with atopic dermatitis, hand eczema and contact sensitization independent of filaggrin gene mutations.
abstract: Atopic dermatitis, hand eczema and contact sensitization are prevalent disorders, and may, in many cases, be secondary to skin barrier abnormality. The aim of this study was to investigate the association between self-reported generalized xerosis, atopic dermatitis, hand eczema and contact sensitization, taking filaggrin gene mutations into account. Questionnaire data were collected from a cross-sectional study performed in a general population in Copenhagen. A total of 3,460 18-69-year-olds were patch-tested and 3,335 were genotyped for the 2282del4 and R501X mutations in the filaggrin gene. Atopic dermatitis and hand eczema were significantly associated with generalized xerosis, whereas contact sensitization (not nickel) showed only a borderline significant association. These results suggest that generalized xerosis may increase the risk of common skin disorders.
authors: National Allergy Research Centre, Copenhagen University Hospital Gentofte, Hellerup, Denmark. jacob.p.thyssen@regionh.dk
authors: Jacob P
authors: JP
authors: Thyssen
authors: Jeanne D
authors: JD
authors: Johansen
authors: Claus
authors: C
authors: Zachariae
authors: Torkil
authors: T
authors: Menné
authors: Allan
authors: A
authors: Linneberg
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D004252:DNA Mutational Analysis; D003718:Denmark / Q000453:epidemiology; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D003877:Dermatitis, Contact / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D004485:Eczema / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D005260:Female; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease; D006229:Hand Dermatoses / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016017:Odds Ratio; D010328:Patch Tests; D010641:Phenotype; D011237:Predictive Value of Tests; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D012867:Skin / Q000473:pathology*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins