title: [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases].
abstract: OBJECTIVE
  Prostate cancer (PCa) has the highest incidence among male malignancies in Western industrialized countries and, as a most common malignant disease in urology, its incidence has been increasing in recent years in Chinese men. This study was to investigate the risk loci associated with PCa susceptibility in Han Chinese by analyzing single nucleotide polymorphisms (SNP).
  
  
  METHODS
  We collected peripheral blood samples from 1 667 PCa patients and 1 525 healthy men, and detected 40 loci associated with PCa susceptibility by analyzing SNPs using Sequenom technology.
  
  
  RESULTS
  Of the 40 known loci, 16 were confirmed to be significantly associated with PCa susceptibility (P < 0.05). The loci 1, 2 and 5 at 8q24, 10q11 and 22q13.2 also contributed to PCa susceptibility in different ethnic groups.
  
  
  CONCLUSIONS
  PCa susceptibility is obviously associated with the risk loci rs1465618, rs721048, rs12621278, rs7679673, rs12653946, rs339331, rs1512268, rs10086908, rs16901979, rs1447295, rs10993994, rs10896449, rs902774, rs9600079, rs11649743 and rs5759167 in Chinese Han population.
authors: Department of Urology, Suzhou City Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu 215001, China.
authors: Yong
authors: Y
authors: Cui
authors: Yi-Chao
authors: YC
authors: Shi
authors: Hua
authors: H
authors: Shen
authors: You-Zhang
authors: YZ
authors: Fan
authors: Wen-Zhou
authors: WZ
authors: Cao
authors: Jian-Jun
authors: JJ
authors: Xie
authors: Huai-Qing
authors: HQ
authors: Su
authors: Qiang
authors: Q
authors: Shao
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors