title: Plasma paraoxonase activity and oxidative stress and their relationship to disease severity in children with allergic rhinitis.
abstract: BACKGROUND
  Oxidative stress may play a role in the pathophysiology of several diseases including allergic rhinitis (AR). In children with AR an antioxidant enzyme paraoxonase (PON1) has not been previously investigated. The aim of this study was to investigate plasma PON1  activity and plasma total oxidant status (TOS), which are in the form of plasma reactive oxidants, and their association with severity of disease in house-mite-sensitive children with AR.
  
  
  METHODS
  This study included 66 children with persistent AR and 40 healthy controls  aged between 7 and 12 years old. Plasma PON1, TOS, and total serum immunoglobulin E (IgE) were measured. The nasal symptom scores and body mass index were evaluated at the time of blood collection.
  
  
  RESULTS
  Mean serum PON1 levels were significantly lower and, TOS levels  were higher in the patient group than in the control group (p ≤ 0.001 and p ≤ 0.002, respectively). A significant negative correlation was observed between serum levels of PON1 and nasal symptom scores. However, serum levels of TOS were correlated with nasal symptom scores positively.  There were no correlations between levels of total IgE and levels of PON1 and TOS levels.
  
  
  CONCLUSIONS
  Plasma PON1 and TOS levels may serve as predictors of disease severity in children with AR and both of them appear to be attractive candidates for modulating inflammation  in AR.
authors: Division of Pediatric Allergy, Bezmialem Vakif University, Istanbul, Turkey. minozkaya@yahoo.com
authors: Emin
authors: E
authors: Ozkaya
authors: Hasan
authors: H
authors: Akduman
authors: Ufuk
authors: U
authors: Erenberk
authors: Aysegul
authors: A
authors: Demir
authors: M Rusen
authors: MR
authors: Dundaroz
mesh_terms: D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D018450:Disease Progression; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress / Q000276:immunology*; D011379:Prognosis; D039981:Pyroglyphidae / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000097:blood / Q000175:diagnosis* / Q000276:immunology
chemical_list: D039741:Antigens, Dermatophagoides; D015415:Biomarkers; D016877:Oxidants; D007073:Immunoglobulin E; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human