title: HIF proteins connect the RB-E2F factors to angiogenesis.
abstract: Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF. (1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulating angiogenesis during embryonic and tumor development.
authors: Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
authors: Walbert J
authors: WJ
authors: Bakker
authors: Bart G M W
authors: BG
authors: Weijts
authors: Bart
authors: B
authors: Westendorp
authors: Alain
authors: A
authors: de Bruin
mesh_terms: D000818:Animals; D001665:Binding Sites; D050684:E2F Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D050684:E2F Transcription Factors; D051793:Hypoxia-Inducible Factor 1; D012097:Repressor Proteins; D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor
keywords: E2F; HIF; RB; VEGF; angiogenesis; cancer; hypoxia