title: Pre-progression rates in Alzheimer's disease revisited.
abstract: BACKGROUND
  Pre-progression rates (PPR) in Alzheimer's disease (AD) have been reported to be associated with cognitive and functional decline.
  
  
  OBJECTIVE
  The objective was to reevaluate PPRs in a prospective cohort of AD patients.
  
  
  METHODS
  A prospective AD cohort was analyzed. Multiple regression was used to examine associations of PPRs with short term decline on different cognitive and functional scales (MMSE, instrumental and basic ADL, GDS, UPDRS III).
  
  
  RESULTS
  PPRs were only associated with first year instrumental ADL declines.
  
  
  CONCLUSIONS
  The predictive abilities of PPRs could partially be confirmed. These findings can help to adapt patient care shortly after diagnosis.
authors: Clinical Dementia Center, Department of Neurology, Georg-August-University, Robert-Koch-Strasse 40, Goettingen, Germany. cschmid2@gwdg.de
authors: Christian
authors: C
authors: Schmidt
authors: André
authors: A
authors: Karch
authors: Svetlana
authors: S
authors: Artjomova
authors: Martin
authors: M
authors: Hoeschel
authors: Inga
authors: I
authors: Zerr
mesh_terms: D000203:Activities of Daily Living / Q000145:classification* / Q000523:psychology; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule / Q000706:statistics & numerical data*; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011594:Psychometrics; D014057:Tomography, X-Ray Computed; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; C054369:MAPT protein, human; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); D016875:tau Proteins