title: [Pleiotropic effects in local drug treatment for                     glaucoma].
abstract: In glaucoma treatment, beside the traditional reduction of intraocular                         pressure, additional therapeutic strategies have come into consideration.                         Therefore pleiotropic effects of medications, defined as positively acting                         effects independent of the main mechanism of action, represent a new                         research sub-field in medical therapy and play an increasingly important                         role in internal medicine. Using the example of local beta-blockers,                         alpha-2-agonists, carbonic anhydrase inhibitors and prostaglandin analogues,                         their pleiotropic spectra will be shown and discussed.
authors: Augenklinik am Wittenbergplatz, Kleiststraße 23–26, Berlin. glaukom.berlin@yahoo.de
authors: C
authors: C
authors: Erb
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage / Q000009:adverse effects; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D015237:Dinoprost / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D004338:Drug Combinations; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D019983:Guideline Adherence; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects* / Q000502:physiology; D009883:Ophthalmic Solutions; D009901:Optic Nerve Diseases / Q000517:prevention & control
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002257:Carbonic Anhydrase Inhibitors; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D015237:Dinoprost