title: A new antibacterial denitroaristolochic acid from the tubers of Stephania succifera.
abstract: A new denitroaristolochic acid, demethylaristofolin C (1), together with six known alkaloids, crebanine N-oxide (2), (-)-sukhodianine-β-N-oxide (3), palmatine (4), corydalmine (5), dehydrocorydalmine (6), and corynoxidine (7), was isolated from the tubers of Stephania succifera. The structure of demethylaristofolin C was elucidated by spectroscopic techniques (UV, IR, 1D, and 2D NMR) and HR-ESI-MS analyses. These compounds exhibited antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.
authors: National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou 57110 , China.
authors: De-Lan
authors: DL
authors: Yang
authors: Wen-Li
authors: WL
authors: Mei
authors: Yan-Bo
authors: YB
authors: Zeng
authors: Zhi-Kai
authors: ZK
authors: Guo
authors: Dai-Jing
authors: DJ
authors: Wei
authors: Shou-Bai
authors: SB
authors: Liu
authors: Qing-Huang
authors: QH
authors: Wang
authors: Hao-Fu
authors: HF
authors: Dai
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001599:Berberine / Q000031:analogs & derivatives; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035281:Plant Tubers / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D031607:Stephania / Q000737:chemistry*
chemical_list: C582387:7,8-dimethoxy-3,4-methylenedioxy-phenanthrene-1-carboxylic acid; D000470:Alkaloids; D000900:Anti-Bacterial Agents; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; D001599:Berberine; C050760:crebanine N-oxide; C007233:dehydrocorydalmine; C058198:corydalmine; C005413:palmatine