title: Semaphorins 3A and 7A: potential immune and neuroregenerative targets in multiple sclerosis.
abstract: Semaphorins have been classically defined as axonal signalling cues involved in central nervous system (CNS) development, but in adults these molecules are expressed in distinct tissues and exert various functions under several physiological and pathological contexts. Semaphorins capable of modulating the immune system are particularly relevant in autoimmune diseases, especially multiple sclerosis (MS), which is a demyelinating, neurodegenerative disease. In this article, we compile recent insights into the specific roles of semaphorin (sema)3A and sema7A to clarify the details of their possible participation in the inflammatory and neurodegenerative phases of MS.
authors: Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Ps. Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
authors: Herena
authors: H
authors: Eixarch
authors: Ana
authors: A
authors: Gutiérrez-Franco
authors: Xavier
authors: X
authors: Montalban
authors: Carmen
authors: C
authors: Espejo
mesh_terms: D000328:Adult; D000818:Animals; D001369:Axons; D004195:Disease Models, Animal; D006801:Humans; D056747:Immunomodulation; D009103:Multiple Sclerosis / Q000276:immunology* / Q000503:physiopathology; D040121:Semaphorin-3A / Q000276:immunology* / Q000378:metabolism; D039961:Semaphorins / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D040121:Semaphorin-3A; D039961:Semaphorins