title: Bioactive phenolics from Seriphidium stenocephalum.
abstract: Chromatographic separation of the ethyl acetate soluble part of the methanolic extract from Seriphidium stenocephalum yielded three new compounds: stenocepflavone (1), stenocepflavan (2), and stenocephol (3), together with cirsimaritin (4), 5,7,5'-trihydroxy-3',4',6-trimethoxyflavone (5), 5,6,7,5'-tetrahydroxy-4'-methoxyflavone (6), and axillaroside (7). All isolates were characterized with the help of spectroscopic data including 1D, 2D NMR, and high resolution mass spectrometry and/or in comparison with the related compounds in literature. All compounds were tested for in vitro enzyme inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and lipoxygenase. Compounds 1 and 4-7 exhibited significant activity against all the tested enzymes, whereas compounds 2 and 3 were found inactive.
authors: Department of Chemistry , Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, 63100 Bahawalpur, Pakistan.
authors: Nusrat
authors: N
authors: Shafiq
authors: Naheed
authors: N
authors: Riaz
authors: Shabir
authors: S
authors: Ahmed
authors: Muhammad
authors: M
authors: Ashraf
authors: Syeda Abida
authors: SA
authors: Ejaz
authors: Ishtiaq
authors: I
authors: Ahmed
authors: Muhammad
authors: M
authors: Saleem
authors: Muhammad Imran
authors: MI
authors: Touseef
authors: Rasool Bakhsh
authors: RB
authors: Tareen
authors: Abdul
authors: A
authors: Jabbar
mesh_terms: D000465:Algorithms; D019659:Asteraceae / Q000737:chemistry*; D002091:Butyrylcholinesterase / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D016859:Lipoxygenase Inhibitors; D010636:Phenols; C582457:stenocepflavan; C582458:stenocepflavone; C582459:stenocephol; D002091:Butyrylcholinesterase