title: NSCLC subtype prediction using cytologic fluid specimens from needle aspiration biopsies.
abstract: This study evaluated the diagnostic usefulness of tumor marker concentrations in cytologic fluids (CF) for subtyping non-small cell lung cancer (NSCLC) and assessed the relationship between fluorine-18-fluorodeoxyglucose ((18)F-FDG) uptake with serum and CF tumor marker levels. This prospective study included 88 patients diagnosed with adenocarcinoma or squamous cell carcinoma (SCC). Cytokeratin-19 fragment (CYFRA 21-1), carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) concentrations in the CF samples were correlated with serum tumor marker concentrations, (18)F-FDG uptake, and NSCLC subtype. Fifty-eight patients were diagnosed with adenocarcinoma. Multivariate analysis revealed higher CF and serum SCCA levels; smoking status predicted SCC from adenocarcinoma. CF SCCA showed the highest accuracy (83%) in distinguishing between SCC and adenocarcinoma. CF samples obtained during routine needle aspiration biopsy procedure contain tumor marker levels sufficient to distinguish between SCC and adenocarcinoma; CF SCCA had the highest diagnostic accuracy.
authors: Division of Nuclear Medicine, Yonsei University College of Medicine, Seoul, South Korea.
authors: Arthur
authors: A
authors: Cho
authors: Jin
authors: J
authors: Hur
authors: Yoo Jin
authors: YJ
authors: Hong
authors: Hye-Jeong
authors: HJ
authors: Lee
authors: Young Jin
authors: YJ
authors: Kim
authors: Hee Yeong
authors: HY
authors: Kim
authors: Ji Won
authors: JW
authors: Lee
authors: Hyo Sup
authors: HS
authors: Shim
authors: Byoung Wook
authors: BW
authors: Choi
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000032:analysis*; D001707:Biopsy, Needle; D001826:Body Fluids / Q000737:chemistry*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D003581:Cytodiagnosis; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D053539:Keratin-19 / Q000032:analysis; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D049268:Positron-Emission Tomography; D012372:ROC Curve; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; D019275:Radiopharmaceuticals; C102012:antigen CYFRA21.1; D019788:Fluorodeoxyglucose F18