title: StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion.
abstract: OBJECTIVE
  This is a case- control study to determine whether G1733A polymorphism of androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA).
  
  
  METHODS
  A total of 85 women with at least two recurrent spontaneous abortion before 20th week of gestation composed the study group. Subjects were genotyped by the polymerase chain reaction restriction fragment length polymorphism method.
  
  
  RESULTS
  The observed frequencies of GG, GA and AA genotypes of the G1733A polymorphism were 5.89 %, 82.35 % and 11.76 %, respectively, for the patient group and 71.76 %, 23.51 % and 4.71 %, respectively, for the control group. Allele frequencies of the G1733A polymorphism among patients and controls were 0.47 and 0.84, respectively, for the dominant allele (G) (wild type) and 0.53 and 0.16, respectively, for the A allele (mutant type).
  
  
  CONCLUSIONS
  These results indicated that the androgen receptor G1733A polymorphism is strongly associated with increased risk for RSA.
authors: Medical Genetics Department, Research and Clinical Centre for Infertility, Yazd Shahid Sadoughi Medical Sciences University and Health Services, Yazd, Iran. N479g@yahoo.co.uk
authors: Tahere
authors: T
authors: Jahaninejad
authors: Nasrin
authors: N
authors: Ghasemi
authors: Seyyed Mehdi
authors: SM
authors: Kalantar
authors: Mohammad Hasan
authors: MH
authors: Sheikhha
authors: Hossein
authors: H
authors: Pashaiefar
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics* / Q000473:pathology; D000328:Adult; D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011944:Receptors, Androgen / Q000235:genetics*
chemical_list: D011944:Receptors, Androgen; C028868:AGGCCT-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific