title: Perinatal outcomes in oocyte donor pregnancies.
abstract: OBJECTIVE
  To assess the obstetric outcomes of pregnancy following intracytoplasmic sperm injection (ICSI) using donor oocytes.
  
  
  METHODS
  Twenty-six deliveries from oocyte donor ICSI (d-ICSI) were compared to the next two consecutive deliveries from homologous ICSI (h-ICSI group) (n = 52) and with the two consecutive deliveries from women older than 40 years (Advanced Maternal Age: AMA) (n = 52). We evaluated the occurrence of gestational hypertension (GH), preeclampsia (PE), fetal growth restriction (IUGR), gestational diabetes mellitus (GDM), preterm premature rupture of membranes (pPROM), preterm birth, placental anomalies, mode of delivery, hemorrhage, gestational age at birth and birth weight.
  
  
  RESULTS
  d-ICSI had significantly more PE (d-ICSI 19.2%, h-ICSI 0%, AMA 0%, p < 0.001); higher rates of IUGR than AMA pregnancies (d-ICSI 19.2%, AMA 3.8%, p < 0.025). Placental accretism was found only in the d-ICSI group (15.4%, p < 0.043). No postpartum bleeding was observed.
  
  
  CONCLUSIONS
  This is the first study that compares the obstetric outcomes of donor pregnancies to the outcomes of h-ICSI and AMA. Obstetricians who deal with pregnancies from oocyte donation need to be aware of the more severe obstetric outcomes, especially placenta accreta and preeclampsia. All women who conceive through oocyte donation should be counseled as early as the pre-conception period and referred to specific centers for high-risk pregnancies.
authors: Department of Clinical Sciences, Università Politecnica Marche, Ancona, Italy. a.l.tranquilli@univpm.it
authors: Andrea L
authors: AL
authors: Tranquilli
authors: Valentina
authors: V
authors: Biondini
authors: Solmas
authors: S
authors: Talebi Chahvar
authors: Alessandra
authors: A
authors: Corradetti
authors: Daniela
authors: D
authors: Tranquilli
authors: Stefano
authors: S
authors: Giannubilo
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D018587:Oocyte Donation / Q000706:statistics & numerical data*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data