title: Bacterial nitric oxide extends the lifespan of C. elegans.
abstract: Nitric oxide (NO) is an important signaling molecule in multicellular organisms. Most animals produce NO from L-arginine via a family of dedicated enzymes known as NO synthases (NOSes). A rare exception is the roundworm Caenorhabditis elegans, which lacks its own NOS. However, in its natural environment, C. elegans feeds on Bacilli that possess functional NOS. Here, we demonstrate that bacterially derived NO enhances C. elegans longevity and stress resistance via a defined group of genes that function under the dual control of HSF-1 and DAF-16 transcription factors. Our work provides an example of interspecies signaling by a small molecule and illustrates the lifelong value of commensal bacteria to their host.
authors: Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
authors: Ivan
authors: I
authors: Gusarov
authors: Laurent
authors: L
authors: Gautier
authors: Olga
authors: O
authors: Smolentseva
authors: Ilya
authors: I
authors: Shamovsky
authors: Svetlana
authors: S
authors: Eremina
authors: Alexander
authors: A
authors: Mironov
authors: Evgeny
authors: E
authors: Nudler
mesh_terms: D000818:Animals; D001412:Bacillus subtilis; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D004032:Diet; D051858:Forkhead Transcription Factors; D041981:Gastrointestinal Tract / Q000382:microbiology; D008136:Longevity; D009569:Nitric Oxide / Q000378:metabolism*; D013696:Temperature; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; C108831:daf-16 protein, C elegans; C474710:heat shock factor-1, C elegans; D009569:Nitric Oxide