title: TCTP/HRF pathway and angiogenesis: a feasible intercourse in chronic lymphocytic leukemia.
abstract: This prospective study was planned to determine the intercourse between translationally controlled tumor protein (TCTP)/histamine releasing factor (HRF)/histamine pathway and angiogenesis in chronic lymphocytic leukemia (CLL). A total of 153 CLL patients were included. Serum histamine levels were higher in CLL patients. A positive correlation was found between microvessel density (MVD)-mast cell (MC) count; MVD-TCTP/HRF and MC count-TCTP/HRF. Microvessel density, MC and ZAP 70 were significantly higher in TCTP/HRF-positive group. Time to first treatment was shorter in patients with increased MVD and TCTP/HRF. Further data is essential to ascertain the role of TCTP/HRF pathway in tumor angiogenesis and CLL prognosis.
authors: Department of Hematology, Gazi University, Ankara, Turkey.
authors: Münci
authors: M
authors: Yağcı
authors: Zeynep Arzu
authors: ZA
authors: Yegin
authors: Nalan
authors: N
authors: Akyürek
authors: Handan
authors: H
authors: Kayhan
authors: Zübeyde Nur
authors: ZN
authors: Ozkurt
authors: Gülsan Türköz
authors: GT
authors: Sucak
authors: Rauf
authors: R
authors: Haznedar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism / Q000502:physiology*; D016022:Case-Control Studies; D018450:Disease Progression; D005240:Feasibility Studies; D005260:Female; D006632:Histamine / Q000097:blood / Q000378:metabolism; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000378:metabolism*; D011379:Prognosis; D015398:Signal Transduction / Q000502:physiology; D000090324:Tumor Protein, Translationally-Controlled 1
chemical_list: D014408:Biomarkers, Tumor; C000715647:TPT1 protein, human; D000090324:Tumor Protein, Translationally-Controlled 1; D006632:Histamine