title: MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas.
abstract: MicroRNAs (miRNAs) are single-stranded, 18- to 23-nt RNA molecules that function as regulators of gene expression. Previous studies have shown that microRNAs play important roles in human cancers, including gliomas. Here, we found that expression levels of miR-181b were decreased in gliomas, and we identified IGF-1R as a novel direct target of miR-181b. MiR-181b overexpression inhibited cell proliferation, migration, invasion, and tumorigenesis by targeting IGF-1R and its downstream signaling pathways, PI3K/AKT and MAPK/ERK1/2. Overexpression of IGF-1R rescued the inhibitory effects of miR-181b. In clinical specimens, IGF-1R was overexpressed, and its protein levels were inversely correlated with miR-181b expression. Taken together, our results indicate that miR-181b functions in gliomas to suppress growth by targeting the IGF-1R oncogene and that miR-181b may serve as a novel therapeutic target for gliomas.
authors: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors: Zhu-Mei
authors: ZM
authors: Shi
authors: Xie-Feng
authors: XF
authors: Wang
authors: Xu
authors: X
authors: Qian
authors: Tao
authors: T
authors: Tao
authors: Lin
authors: L
authors: Wang
authors: Qiu-Dan
authors: QD
authors: Chen
authors: Xi-Rui
authors: XR
authors: Wang
authors: Lei
authors: L
authors: Cao
authors: Ying-Yi
authors: YY
authors: Wang
authors: Jun-Xia
authors: JX
authors: Zhang
authors: Tao
authors: T
authors: Jiang
authors: Chun-Sheng
authors: CS
authors: Kang
authors: Bing-Hua
authors: BH
authors: Jiang
authors: Ning
authors: N
authors: Liu
authors: Yong-Ping
authors: YP
authors: You
mesh_terms: D020533:Angiogenesis Inhibitors / Q000378:metabolism; D000818:Animals; D002465:Cell Movement; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D016147:Genes, Tumor Suppressor; D005910:Glioma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020533:Angiogenesis Inhibitors; C540193:MIrn181 microRNA, human; D035683:MicroRNAs; D017526:Receptor, IGF Type 1