title: CD154: the atherosclerotic risk factor in rheumatoid arthritis?
abstract: Atherosclerosis, now regarded as a chronic inflammatory disease of the arterial wall, and its clinical manifestations have increasingly been associated with rheumatoid arthritis (RA), supporting the notion that autoimmune diseases and vascular disorders share common etiological features. Indeed, evidence pertaining to this matter indicates that inflammation and its multiple components are the driving force behind the pathogenesis of these disorders. Interestingly, CD154 and its receptors have emerged as major players in the development of RA and atherosclerosis, which raises the possibility that this axis may represent an important biological link between both complications. Indeed, CD154 signaling elicits critical inflammatory responses that are common to the pathogenesis of both diseases. Here, we provide an overview of the traditional and disease-related interrelations between RA and vascular abnormalities, while focusing on CD154 as a potential mediator in the development of atherosclerotic events in RA patients.
authors: Ghada S
authors: GS
authors: Hassan
authors: Daniel
authors: D
authors: Yacoub
authors: Nada
authors: N
authors: Alaaeddine
authors: Amal
authors: A
authors: Nadiri
authors: Yahye
authors: Y
authors: Merhi
authors: Walid
authors: W
authors: Mourad
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology*; D050197:Atherosclerosis / Q000276:immunology*; D023201:CD40 Ligand / Q000276:immunology*; D006801:Humans; D012307:Risk Factors
chemical_list: D023201:CD40 Ligand