title: Two new koumine-type indole alkaloids from Gelsemium elegans Benth.
abstract: Two new indole alkaloids, 21-oxokoumine (1) and furanokoumine (2), were isolated from the roots of Gelsemium elegans Benth together with three known compounds. The structures of the two novel compounds were elucidated by spectroscopic methods, including NMR, HR-ESI-MS, UV, IR, CD and molecular modeling. Compound 1 is the first instance of a koumine-type alkaloid with a carbonyl at the C-21 position, while compound 2 possesses a tetrahydrofuran ring located on C-20 and C-21.
authors: Lab of Toxicology and Pharmacology, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
authors: Mingxue
authors: M
authors: Sun
authors: Xiaoli
authors: X
authors: Hou
authors: Huanhuan
authors: H
authors: Gao
authors: Junsheng
authors: J
authors: Guo
authors: Kai
authors: K
authors: Xiao
mesh_terms: D031450:Gelsemium / Q000737:chemistry*; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
chemical_list: D026121:Indole Alkaloids; C515085:koumine