title: Resveratrol mitigates genotoxicity induced by iodine-131 in primary human lymphocytes.
abstract: The purpose of this study was to investigate the radioprotective effects of resveratrol as a natural product that protects against genotoxic actions of (131)I in cultured human lymphocytes. Whole-blood samples from human volunteers were treated with resveratrol at doses of 0.5, 1, 5, and 50 μg/mL for 1 h, after which the lymphocytes were incubated with (131)I (100 μCi/1.5 mL) for 2 h. The lymphocyte cultures were then mitogenically stimulated to enable evaluation of the number of micronuclei in cytokinesis-blocked binucleated cells. Incubation of lymphocytes with (131)I induced genotoxicity, which was reflected by an increase in micronuclei frequency. At the doses tested, resveratrol significantly reduced micronuclei frequency. Maximal protective effects occurred at a dose of 1 μg/mL, with total micronuclei values being reduced by 65 % compared to controls. In conclusion, our results indicate protective effects of resveratrol at low doses against genetic damage and adverse effects induced by (131)I administration.
authors: Department of Radiopharmacy, Faculty of Pharmacy and Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Monireh
authors: M
authors: Hedayati
authors: Nayereh
authors: N
authors: Shafaghati
authors: Seyed Jalal
authors: SJ
authors: Hosseinimehr
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D006801:Humans; D007457:Iodine Radioisotopes / Q000633:toxicity*; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D007457:Iodine Radioisotopes; D009153:Mutagens; D011837:Radiation-Protective Agents; D013267:Stilbenes; D000077185:Resveratrol