title: Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi's Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus.
abstract: As obligate intracellular pathogens, viruses depend on the host cell machinery to complete their life cycle. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus causally linked to the development of Kaposi's sarcoma and several other lymphoproliferative malignancies. KSHV entry into cells is tightly regulated by diverse viral and cellular factors. In particular, KSHV actively engages cellular integrins and ubiquitination pathways for successful infection. Emerging evidence suggests that KSHV hijacks both actin and microtubule cytoskeletons at different phases during entry into cells. Here, we review recent findings on the early events during primary infection of KSHV and its closely related primate homolog rhesus rhadinovirus with highlights on the regulation of cellular cytoskeletons and signaling pathways that are important for this phase of virus life cycle.
authors: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA90033, USA.
authors: Wei
authors: W
authors: Zhang
authors: Shou-Jiang
authors: SJ
authors: Gao
keywords: Kaposi’s Sarcoma-Associated Herpesvirus (KSHV); Rhesus Rhadinovirus (RRV); actin; cellular signaling; endocytosis; integrin; microtubule; ubiquitination; virus entry