title: Hg(II)-mediated intramolecular cyclization reaction in aqueous media and its application as Hg(II) selective indicator.
abstract: The Hg(II)-specific intramolecular cyclization reaction of ethynyl phenols was carried out for the first time in semiaqueous media at ambient temperature. The reaction unit (ethynyl phenol) was coupled with a malononitrile derivative (signal unit), which afforded the chromogenic Hg(II) indicator 7. The reaction of the chromogenic Hg(II) indicator 7 was further optimized in DMSO/water (3:7, v/v) (10 mM PBS buffer, pH = 7.0). Compound 7 displays a color change from blue to pale yellow in the presence of Hg(II).
authors: Department of Chemistry, Inha University, 253 Yonghyundong, Namgu, Incheon 402-751, Republic of Korea.
authors: Ananta Kumar
authors: AK
authors: Atta
authors: Seul-Bi
authors: SB
authors: Kim
authors: Jungseok
authors: J
authors: Heo
authors: Dong-Gyu
authors: DG
authors: Cho
mesh_terms: D003124:Colorimetry; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006863:Hydrogen-Ion Concentration; D008628:Mercury / Q000032:analysis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D009570:Nitriles; D014867:Water; C000945:dicyanmethane; D008628:Mercury