title: Validation of a screening battery to predict driving fitness in people with Parkinson's disease.
abstract: BACKGROUND
  We previously developed a short clinical battery, consisting of contrast sensitivity, Clinical Dementia Rating, the Unified Parkinson's Disease Rating Scale-motor section (UPDRS III), and disease duration, which correctly classified 90% of drivers with Parkinson's Disease (PD). The aim of this study was to validate that screening battery in a different sample of PD drivers.
  
  
  METHODS
  Sixty drivers with PD were enrolled to validate our original screening battery to predict driving fitness decisions (pass-fail) by a state agency where drivers underwent detailed visual, cognitive, and on-road testing.
  
  
  RESULTS
  Twenty-four participants (40%) failed the driving evaluation. The screening battery correctly classified 46 (77%) participants (sensitivity and negative predictive value = 96%; specificity and positive predictive value = 64%). Adding other clinical predictors (e.g., age of onset, Hoehn-Yahr stage instead of UPDRS III) failed to improve the specificity of the model when the sensitivity was kept constant at 96%. However, a driving simulator evaluation improved the specificity of the model to 94%.
  
  
  CONCLUSIONS
  The original clinical battery proved to be a valid screening tool that accurately identifies fit drivers with PD and select those who need more detailed testing at specialized centers.
authors: Department of Rehabilitation Sciences, KU Leuven, Heverlee, Belgium. hannes.devos@faber.kuleuven.be
authors: Hannes
authors: H
authors: Devos
authors: Wim
authors: W
authors: Vandenberghe
authors: Alice
authors: A
authors: Nieuwboer
authors: Mark
authors: M
authors: Tant
authors: Willy
authors: W
authors: De Weerdt
authors: Jeffrey D
authors: JD
authors: Dawson
authors: Ergun Y
authors: EY
authors: Uc
mesh_terms: D000368:Aged; D001334:Automobile Driving; D003198:Computer Simulation; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000175:diagnosis* / Q000523:psychology*; D011237:Predictive Value of Tests; D011597:Psychomotor Performance; D012189:Retrospective Studies