title: Severe sepsis caused by a linezolid-resistant Enterococcus faecium in a 10-year-old girl after multiple trauma.
abstract: While infections caused by Enterococcus faecium resistant to vancomycin (VRE) are increasing, linezolid-resistant strains are still rare. We present the case of a 10-year-old girl with severe sepsis caused by a linezolid-resistant E. faecium (Van-B VRE) after multiple trauma and right-sided hemipelvectomy. The off-label use of a targeted antimicrobial therapy with daptomycin (350 mg/day; approximately 8 mg/kg) for 17 days resulted in rapid normalization of infection parameters and improved clinical status. No side effects were observed and the patient was successfully discharged from the intensive care unit.
authors: Department of Trauma and Orthopedic Surgery, University Witten/Herdecke, Cologne-Merheim Medical Center (CMMC), Ostmerheimerstr. 200, D-51109 Cologne, Germany. manuelmutschler@web.de
authors: M
authors: M
authors: Mutschler
authors: S
authors: S
authors: Trojan
authors: J M
authors: JM
authors: Defosse
authors: A
authors: A
authors: Helmers
authors: C
authors: C
authors: Probst
authors: B
authors: B
authors: Bouillon
authors: F
authors: F
authors: Wappler
authors: S G
authors: SG
authors: Sakka
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D024881:Drug Resistance, Bacterial; D016984:Enterococcus faecium / Q000187:drug effects*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000209:etiology / Q000382:microbiology*; D006801:Humans; D000069349:Linezolid; D009104:Multiple Trauma / Q000150:complications*; D023303:Oxazolidinones / Q000494:pharmacology*; D018805:Sepsis / Q000209:etiology / Q000382:microbiology*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid