title: Acute anterior uveitis following intravitreal injection of bevacizumab.
abstract: OBJECTIVE
  To report five cases of iritis after intravitreal injection of bevacizumab.
  
  
  METHODS
  The clinical charts of patients who received intravitreal injections of bevacizumab or ranibizumab from January 2009 to September 2011 by one physician were retrospectively reviewed.
  
  
  RESULTS
  A total of 1,097 injections of bevacizumab and 571 of ranibizumab were administered. Five patients developed acute anterior uveitis and presented with severe pain, photophobia, conjunctival injection, and anterior chamber reaction 2 to 24 hours after intravitreal injection of bevacizumab. All five patients were treated with topical corticosteroids with rapid resolution of the inflammation.
  
  
  CONCLUSIONS
  Although uncommon, acute iritis is a complication of intravitreal injection of bevacizumab.
authors: Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10461, USA. ophthoman@ymail.com
authors: Arash
authors: A
authors: Mozayan
authors: Samer
authors: S
authors: Farah
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects* / Q000627:therapeutic use; D000068258:Bevacizumab; D003231:Conjunctivitis / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D058447:Eye Pain / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D058449:Intravitreal Injections; D007500:Iritis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D020795:Photophobia / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D000069579:Ranibizumab; D012164:Retinal Diseases / Q000188:drug therapy; D012189:Retrospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D005938:Glucocorticoids; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab; D000069579:Ranibizumab