title: Intercellular synchronization of coupled smooth muscle cells via Ca2+ propagation.
abstract: The propagation of Ca2+ wave through gap junction in smooth muscle cell is studied as a function of electrical coupling parameter (g) modulated by Ca2+ level in the cell. The range of activation time of Ca2+ propagation with amplitude is found to increase as increase in electrical coupling parameter g, which is identified by increase in critical time of activation, T(F) as a function of g. Then identical Ca2+ oscillators are allowed to interact via electrical and diffusive coupling of Ca2+ ions diffused through gap junctions, and rate of intercellular synchronization among them is studied. The phase diagrams in (T(F) - g) and (T(F) - epsilon) parameter spaces separate oscillation death and damped oscillations regimes which correspond to deactivated and activated regimes of Ca2+ level. The effect of on T(F) is significantly very slow, however it enhances the rate of synchronization among the coupled oscillators. The increase in g comparatively slows down the rate of synchronization of the coupled oscillators as shown in the phase diagram in (epsilon - g) parameter space which separates desynchronized and synchronized regimes.
authors: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
authors: Md Zubbair
authors: MZ
authors: Malik
authors: Shahnawaz
authors: S
authors: Ali
authors: Md Jahoor
authors: MJ
authors: Alam
authors: Gurumayum Reenaroy
authors: GR
authors: Devi
authors: Ravins
authors: Romana
authors: R
authors: Ishrat
authors: R K Brojen
authors: RK
authors: Singh
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D008959:Models, Neurological; D032389:Myocytes, Smooth Muscle / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D002118:Calcium