title: Risk factors for comorbidity in ADHD and GTS: looking beyond a single-deficit model.
abstract: Attention-deficit hyperactivity disorder (ADHD) and Gilles de la Tourette syndrome (GTS) are commonly co-occurring neurodevelopmental conditions. This article explores the mechanism of co-occurrence by describing shared biogenetic, neural, and cognitive risk factors between the two disorders. Neuroanatomical risk factors underlie atypical neuropsychological profiles of motor control and inhibition. Features of inhibition (impulsivity in ADHD and tics in GTS) may be a disadvantage in ADHD but may present as a protective factor in GTS. The application of cognitive manifestations for assessment and behavioral management in GTS is considered.
authors: Tourette Syndrome Clinic, Great Ormond Street Hospital for Children NHS Foundation Trust, London, England. DrTaraMurphy@gmail.com
authors: Tara
authors: T
authors: Murphy
authors: Valerie
authors: V
authors: Muter
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D015897:Comorbidity; D006801:Humans; D008960:Models, Psychological; D012307:Risk Factors; D005879:Tourette Syndrome / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology