title: Complete Versus culprit-Lesion only PRimary PCI Trial (CVLPRIT): a multicentre trial testing management strategies when multivessel disease is detected at the time of primary PCI: rationale and design.
abstract: OBJECTIVE
  Primary percutaneous coronary intervention (PPCI) is the preferred strategy for acute ST-segment elevation myocardial infarction (STEMI), with evidence of improved clinical outcomes compared to fibrinolytic therapy. However, there is no consensus on how best to manage multivessel coronary disease detected at the time of PPCI, with little robust data on best management of angiographically significant stenoses detected in non-infarct-related (N-IRA) coronary arteries. CVLPRIT will determine the optimal management of N-IRA lesions detected during PPCI.
  
  
  RESULTS
  CVLPRIT (Complete Versus culprit-Lesion only PRimary PCI Trial) is an open-label, prospective, randomised, multicentre trial. STEMI patients undergo verbal "assent" on presentation. Patients are included when angiographic MVD has been detected, and randomised to culprit (IRA)-only PCI (n=150) or in-patient complete multivessel PCI (n=150). Cumulative major adverse cardiac events (MACE) - all-cause mortality, recurrent MI, heart failure, need for revascularisation (PCI or CABG) will be recorded at 12 months. Secondary endpoints include safety endpoints of confirmed ischaemic stroke, intracranial haemorrhage, major non-intracranial bleeding, and repair of vascular complications. A cardiac magnetic resonance (CMR) substudy will provide mechanistic data on infarct size, myocardial salvage index and microvascular obstruction. A cost efficacy analysis will be undertaken.
  
  
  CONCLUSIONS
  The management of multivessel coronary artery disease in the setting of PPCI for STEMI, including the timing of when to perform non-culprit-artery revascularisation if undertaken, remains unresolved. CVLPRIT will yield mechanistic insights into the myocardial consequence of N-IRA intervention undertaken during the peri-infarct period.
authors: Department of Cardiology, University Hospitals of Leicester, Leicester, United Kingdom.
authors: Damian J
authors: DJ
authors: Kelly
authors: Gerald P
authors: GP
authors: McCann
authors: Daniel
authors: D
authors: Blackman
authors: Nicholas P
authors: NP
authors: Curzen
authors: Miles
authors: M
authors: Dalby
authors: John P
authors: JP
authors: Greenwood
authors: Kathryn
authors: K
authors: Fairbrother
authors: Lorraine
authors: L
authors: Shipley
authors: Andrew
authors: A
authors: Kelion
authors: Simon
authors: S
authors: Heatherington
authors: Jamal N
authors: JN
authors: Khan
authors: Sheraz
authors: S
authors: Nazir
authors: Albert
authors: A
authors: Alahmar
authors: Marcus
authors: M
authors: Flather
authors: Howard
authors: H
authors: Swanton
authors: Peter
authors: P
authors: Schofield
authors: Mark
authors: M
authors: Gunning
authors: Roger
authors: R
authors: Hall
authors: Anthony H
authors: AH
authors: Gershlick
mesh_terms: D003324:Coronary Artery Disease / Q000628:therapy*; D023381:Endpoint Determination; D006801:Humans; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D012107:Research Design