title: Congenital langerhans cell histiocytosis with placental involvement.
abstract: Congenital presentations of Langerhans cell histiocytosis (LCH) are exceedingly rare, and concurrent placental parenchymal involvement has not been definitively documented in the literature. We present 2 cases of congenital multisystem LCH with placental involvement resembling chronic villitis. Placental examination may provide the initial diagnostic evidence of LCH and may significantly influence patient management and outcome; however, the prognostic implications remain unclear. In a clinical context suspicious for congenital LCH, the observation of chronic villitis should prompt consideration of placental involvement by LCH.
authors: Department of Pathology, Boston Children's Hospital and Harvard Medical School, Room BA-121, 300 Longwood Avenue, Boston, MA 02115, USA. jterry@hhsc.ca
authors: Jefferson
authors: J
authors: Terry
authors: Francesca R
authors: FR
authors: Pluchinotta
authors: Stephen P
authors: SP
authors: Sanders
authors: Jo-Anne
authors: JA
authors: Vergilio
authors: Scott R
authors: SR
authors: Hyde
authors: Theonia K
authors: TK
authors: Boyd
mesh_terms: D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000151:congenital* / Q000473:pathology*; D006801:Humans; D008297:Male; D010920:Placenta / Q000473:pathology; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy