title: [Recurrent venous thromboembolic events--a prospective study].
abstract: The reccurency rate after venous thromboembolism (VTE) is high and risk factors for recurrent thromboembolic events were investigated only on a small scale.
  
  
  OBJECTIVE
  estimating the cumulative incidence of recurrent venous thromboembolism after a first episode of venous thromboembolism, identification of risk factors for recurrent venous thromboembolism, of the optimal methods of diagnosis and establish a proper treatment protocol.
  
  
  METHODS
  we conducted a prospective study for 2 years on 401 patients with objectively verified symptomatic VTE. Medical records were reviewed for all patients during follow-up and episodes of recurrent thromboembolism were recorded.
  
  
  RESULTS
  the incidence of recurrent venous thromboembolic events at 2 years was 16.54% after a first episode of VTE. The incidence of fatal pulmonary embolism after 2 years was 4.54%. Proximal deep venous thrombosis (DVT), malignancy and history of venous thromboembolism predict an increased risk of recurrent events. Postoperative DVT and long-term oral anticoagulant treatment involve a lower risk of recurrent events. Sex, age, initial antithrombotic therapy or immobilization did not affect the risk of a recurrent event. Correctly managed anticoagulant therapy decreases the reccurency rate.
  
  
  CONCLUSIONS
  The recurrence rate after a symptomatic DVT is high. Patients with proximal DVT; diagnosed cancer, short-term oral anticoagulant treatment or a history of thromboembolic events had a higher risk of recurrent events, while patients with postoperative DVT, but without neoplasia had a lower recurrence rate.
authors: Spitalul Clinic Sanador, Bucureşti. ionutogdan@yahoo.com
authors: Ionuţ
authors: I
authors: Munteanu
authors: Ioana
authors: I
authors: Munteanu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000517:prevention & control; D011788:Quality of Life; D018570:Risk Assessment; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D055502:Secondary Prevention; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants