title: Effects of simultaneous immunization of Haemophilus influenzae type b conjugate vaccine and diphtheria-tetanus-acellular pertussis vaccine on anti-tetanus potencies in mice, guinea pigs, and rats.
abstract: Haemophilus influenzae type b vaccine conjugated with tetanus toxoid (HibT) was licensed for use in childhood immunization in Japan in 2007. As adsorbed diphtheria-tetanus-acellular pertussis (DTaP) combined with HibT vaccine has not been introduced in Japan, DTaP and HibT vaccines are injected at separate sites with a similar immunization schedule. There are various interfering or stimulatory effects between components of combined vaccines contained in DTaP and HibT vaccines. In this study, we investigated the effect of HibT containing combination vaccines on anti-tetanus potencies by using animal models (mouse, guinea pig, and rat). HibT vaccine and HibT components of imported DTaP-HibT vaccine alone showed comparable or higher anti-tetanus potency than DTaP vaccine and DTaP-containing components of combination vaccines. Mixing these components before injection resulted in potencies greater than the sum of individual potencies. Injecting individual components at separate sites in animals resulted in potency roughly equivalent to the sum of the individual potencies. These results provide useful information regarding the use of HibT-containing multivalent vaccines in childhood immunization.
authors: Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo 208-0011, Japan. yfukuda@nih.go.jp
authors: Tadashi
authors: T
authors: Fukuda
authors: Masaaki
authors: M
authors: Iwaki
authors: Takako
authors: T
authors: Komiya
authors: Keigo
authors: K
authors: Shibayama
authors: Motohide
authors: M
authors: Takahashi
authors: Hideki
authors: H
authors: Nakashima
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood; D016667:Bacterial Capsules; D004165:Diphtheria / Q000517:prevention & control*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage* / Q000592:standards; D005260:Female; D006168:Guinea Pigs; D006192:Haemophilus Infections / Q000517:prevention & control*; D018073:Haemophilus Vaccines / Q000008:administration & dosage* / Q000592:standards; D007114:Immunization; D007564:Japan; D051379:Mice; D023421:Models, Animal; D051381:Rats; D013047:Specific Pathogen-Free Organisms; D013742:Tetanus / Q000517:prevention & control*; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000592:standards; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D017778:Vaccines, Combined