title: A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction.
abstract: 1,10-Phenanthroline-5,6-dione and l-tyrosine methyl ester react to form phenanthroline-oxazine (PDT) from which [Cu(PDT)(2)](ClO(4))(2) and [Ag(PDT)(2)]ClO(4)·2MeOH are obtained. Binding to calf-thymus DNA by Ag(I) and Cu(II) PDT complexes exceed bis-1,10-phenanthroline analogues and the minor groove binding drugs, pentamidine and netropsin. Furthermore, unlike the artificial metallonuclease, [Cu(phen)(2)](2+), the [Cu(PDT)(2)](2+) complex does not cleave DNA in the presence of added reductant indicating unique interaction with DNA.
authors: Department of Chemistry, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland. mmcann@nuim.ie
authors: Malachy
authors: M
authors: McCann
authors: John
authors: J
authors: McGinley
authors: Kaijie
authors: K
authors: Ni
authors: Mark
authors: M
authors: O'Connor
authors: Kevin
authors: K
authors: Kavanagh
authors: Vickie
authors: V
authors: McKee
authors: John
authors: J
authors: Colleran
authors: Michael
authors: M
authors: Devereux
authors: Nicholas
authors: N
authors: Gathergood
authors: Niall
authors: N
authors: Barron
authors: Andreea
authors: A
authors: Prisecaru
authors: Andrew
authors: A
authors: Kellett
mesh_terms: D000818:Animals; D001665:Binding Sites; D002417:Cattle; D056831:Coordination Complexes / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008968:Molecular Conformation; D009429:Netropsin / Q000737:chemistry; D010078:Oxazines / Q000737:chemistry*; D010084:Oxidation-Reduction; D010419:Pentamidine / Q000737:chemistry; D010618:Phenanthrolines / Q000737:chemistry*; D012834:Silver / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D010078:Oxazines; D010618:Phenanthrolines; D012834:Silver; D009429:Netropsin; D010419:Pentamidine; D003300:Copper; D004247:DNA; C427203:calf thymus DNA; C025205:1,10-phenanthroline