title: Direct correlation of electrochemical behaviors with anti-thrombogenicity of semiconducting titanium oxide films.
abstract: Biomaterials-associated thrombosis is dependent critically upon electrochemical response of fibrinogen on material surface. The relationship between the response and anti-thrombogenicity of biomaterials is not well-established. Titanium oxide appears to have good anti-thrombogenicity and little is known about its underlying essential chemistry. We correlate their anti-thrombogenicity directly to electrochemical behaviors in fibrinogen containing buffer solution. High degree of inherent n-type doping was noted to contribute the impedance preventing charge transfer from fibrinogen into film (namely its activation) and consequently reduced degree of anti-thrombogenicity. The impedance was the result of high donor carrier density as well as negative flat band potential.
authors: 1Key Laboratory of Advanced Technologies of Materials, Ministry of Education, College of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China.
authors: Guojiang
authors: G
authors: Wan
authors: Bo
authors: B
authors: Lv
authors: Guoshou
authors: G
authors: Jin
authors: Manfred F
authors: MF
authors: Maitz
authors: Jianzhang
authors: J
authors: Zhou
authors: Nan
authors: N
authors: Huang
mesh_terms: D001792:Blood Platelets / Q000166:cytology / Q000201:enzymology; D002448:Cell Adhesion; D058266:Dielectric Spectroscopy; D004563:Electrochemistry; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D010314:Partial Thromboplastin Time; D056951:Photoelectron Spectroscopy; D012666:Semiconductors; D013918:Thrombin Time; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: C009495:titanium dioxide; D005340:Fibrinogen; D014025:Titanium; D007770:L-Lactate Dehydrogenase
keywords: Anti-thrombogenicity; biomaterials-associated thrombosis; blood compatibility; electrochemical behavior; interfacial charge transfer; titanium oxide film