title: Arenavirus budding: a common pathway with mechanistic differences.
abstract: The Arenaviridae is a diverse and growing family of viruses that includes several agents responsible for important human diseases. Despite the importance of this family for public health, particularly in Africa and South America, much of its biology remains poorly understood. However, in recent years significant progress has been made in this regard, particularly relating to the formation and release of new enveloped virions, which is an essential step in the viral lifecycle. While this process is mediated chiefly by the viral matrix protein Z, recent evidence suggests that for some viruses the nucleoprotein (NP) is also required to enhance the budding process. Here we highlight and compare the distinct budding mechanisms of different arenaviruses, concentrating on the role of the matrix protein Z, its known late domain sequences, and the involvement of cellular endosomal sorting complex required for transport (ESCRT) pathway components. Finally we address the recently described roles for the nucleoprotein NP in budding and ribonucleoprotein complex (RNP) incorporation, as well as discussing possible mechanisms related to its involvement.
authors: Institut für Virologie, Philipps Universität Marburg, Hans-Meerwein-strasse 2, 35043 Marburg, Germany. wolffs@staff.uni-marburg.de
authors: Svenja
authors: S
authors: Wolff
authors: Hideki
authors: H
authors: Ebihara
authors: Allison
authors: A
authors: Groseth
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D001117:Arenaviridae Infections / Q000188:drug therapy / Q000378:metabolism; D018050:Arenavirus / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport; D054884:Host-Pathogen Interactions; D006801:Humans; D009698:Nucleoproteins / Q000378:metabolism; D011485:Protein Binding; D012261:Ribonucleoproteins / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism; D057074:Virus Release / Q000187:drug effects / Q000502:physiology*
chemical_list: D000998:Antiviral Agents; D056827:Endosomal Sorting Complexes Required for Transport; D009698:Nucleoproteins; D012261:Ribonucleoproteins; D014764:Viral Proteins