title: Branch retinal vein occlusion and optic nerve head topographic parameters: the Singapore Indian eye study.
abstract: OBJECTIVE
  To examine the association between branch retinal vein occlusion (BRVO) and quantitative optic disc topographic parameters.
  
  
  METHODS
  The Singapore Indian Eye Study (SINDI) is a population-based study of 3400 Singapore Indians aged 40+ years. BRVO was defined and graded from retinal photographs. Optic disc parameters were quantified using the Heidelberg Retinal Tomograph III (HRT III). Associations were evaluated for individual eyes; the generalised estimating equation was used to account for correlation between fellow eyes.
  
  
  RESULTS
  6173 eyes (comprising 19 BRVO) had gradable retinal photographs and HRT images. After controlling for age, gender, and systemic (hypertension, diabetes, myocardial infarction) and ocular factors (intraocular pressure, glaucoma, central corneal thickness, axial length, previous laser photocoagulation), BRVO was associated with larger optic disc area (OR highest vs lowest tertile, 4.70; 95% CI 1.00 to 22.01; p=0.036), larger cup area (OR highest vs lowest tertile, 4.80; 95% CI 1.03 to 22.35; p=0.029) and larger cup-disc area ratio (OR highest vs lowest tertile, 4.44; 95% CI 0.95 to 20.66; p=0.037). After excluding glaucoma eyes, BRVO remained significantly associated with these parameters (p=0.027, p=0.018, p=0.024, respectively).
  
  
  CONCLUSIONS
  Quantitative optic disc parameters (optic cup and disc area) are associated with BRVO, even in non-glaucomatous eyes. Optic nerve head morphology may play a role in BRVO pathogenesis.
authors: Department of Ophthalmology, National University Hospital, National University Health System, Singapore, Singapore.
authors: Errol Wei'en
authors: EW
authors: Chan
authors: Tien Yin
authors: TY
authors: Wong
authors: Jiemin
authors: J
authors: Liao
authors: Carol Yim-lui
authors: CY
authors: Cheung
authors: Ying Feng
authors: YF
authors: Zheng
authors: Jie Jin
authors: JJ
authors: Wang
authors: Paul
authors: P
authors: Mitchell
authors: Seng Chee
authors: SC
authors: Loon
authors: Seang-Mei
authors: SM
authors: Saw
authors: Tin
authors: T
authors: Aung
authors: Ching-Yu
authors: CY
authors: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058452:Axial Length, Eye / Q000473:pathology; D063171:Corneal Pachymetry; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000150:complications / Q000175:diagnosis / Q000208:ethnology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000208:ethnology; D007194:India / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis / Q000208:ethnology; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000150:complications* / Q000175:diagnosis / Q000208:ethnology; D012029:Refraction, Ocular; D012170:Retinal Vein Occlusion / Q000175:diagnosis / Q000208:ethnology / Q000209:etiology*; D012307:Risk Factors; D012846:Singapore / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014054:Tomography; D014792:Visual Acuity / Q000502:physiology