title: [CT manifestations of liver involvement in children with Langerhans cell histiocytosis].
abstract: OBJECTIVE
  To investigate the computed tomography (CT) manifestations of liver involvement in children with Langerhans cell histiocytosis (LCH).
  
  
  METHODS
  Retrospective analysis was performed on 9 LCH children with liver involvement confirmed by clinical, laboratory and pathological examinations to investigate the CT manifestations of this condition. These children, including 6 males and 3 females, had undergone both plain CT scan and dual-phase (the arterial and portal venous phases) contrast-enhanced CT scan.
  
  
  RESULTS
  The main CT manifestations included hepatomegaly (8 cases); periportal dendritic hypodense lesions or "periportal halo sign" (7 cases) which were mildly or moderately enhanced in the arterial phase; intrahepatic bile duct dilatation (5 cases); lymphadenopathy in the hepatic hilar or retroperitoneal region (4 cases); and diffuse small hypodense nodules (3 cases), which showed annular enhancement on the contrast-enhanced CT scan.
  
  
  CONCLUSIONS
  CT findings may be helpful in the early diagnosis and treatment of LCH in children.
authors: Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
authors: Hui
authors: H
authors: Liu
authors: Xue-Ying
authors: XY
authors: Long
authors: Wen-Zheng
authors: WZ
authors: Li
authors: Xiao-Yi
authors: XY
authors: Wang
authors: Jue
authors: J
authors: Cao
authors: Zhi-Jun
authors: ZJ
authors: Liu
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006529:Hepatomegaly / Q000000981:diagnostic imaging; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*