title: Stabilin-2 acts as an engulfment receptor for the phosphatidylserine-dependent clearance of primary necrotic cells.
abstract: Phosphatidylserine (PS) exposed by necrotic cells serves as an engulfment signal for their effective clearance. However, the molecular mechanism responsible for the PS-dependent clearance of necrotic cells remains to be investigated. Here, we show that stabilin-2 acts as a receptor for necrotic cell clearance. Stabilin-2-mediated necrotic cell engulfment occurred in a PS-dependent manner. EGF-like domain repeat (a PS-recognition domain of stabilin-2) bound to necrotic cells and inhibited the stabilin-2-mediated engulfment. However, primary necrotic cells did not induce the anti-inflammatory effect in stabilin-2-expressing cells. These findings facilitate the elucidation of the molecular mechanisms responsible for the PS-dependent clearance of necrotic cells.
authors: Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea.
authors: Shilpa
authors: S
authors: D'Souza
authors: Seung-Yoon
authors: SY
authors: Park
authors: In-San
authors: IS
authors: Kim
mesh_terms: D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism*; D002478:Cells, Cultured; D006801:Humans; D056747:Immunomodulation; D019169:Jurkat Cells; D051379:Mice; D009336:Necrosis / Q000276:immunology* / Q000473:pathology; D010718:Phosphatidylserines / Q000378:metabolism*
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D010718:Phosphatidylserines; C449927:STAB2 protein, human