title: Intraocular pressure spikes after a sequential laser peripheral iridotomy for angle closure.
abstract: OBJECTIVE
  To determine the incidence of intraocular pressure (IOP) spikes within the first 30 minutes after sequential argon-Nd:YAG laser peripheral iridotomy (LPI) in patients with angle closure and to explore risk factors for their occurrence.
  
  
  METHODS
  A total of 428 consecutive eyes of 298 patients who had undergone LPI at the Singapore National Eye Centre between June 2011 and August 2011 were reviewed retrospectively. There were 238 primary angle closure suspect eyes, 85 primary angle closure eyes, 92 primary angle closure glaucoma eyes, and 13 acute primary angle closure (APAC) eyes. The pre-LPI IOP and post-LPI IOP, gonioscopic findings, medications, laser parameters, and the need for acute IOP-lowering treatment were recorded.
  
  
  RESULTS
  The proportion of patients with a post-LPI IOP elevation ≥8 mm Hg was 10.7% (n=46) and those with a significant IOP spike of ≥30 mm Hg was 31 (7.2%). There were no significant differences between those with or without a post-LPI IOP elevation ≥8 mm Hg and those with or without a post-LPI IOP of ≥30 mm Hg, in terms of age, gender, race, total laser energy used, and seniority of the physician performing the procedure. Patients who experienced IOP spike ≥8 mm Hg were on fewer pre-LPI medications (P=0.009). On logistic regression, patients with APAC had a significantly higher probability of an IOP spike (P=0.003).
  
  
  CONCLUSIONS
  The incidence of postsequential LPI IOP elevation ≥8 mm Hg was 10.7%. The primary diagnosis of APAC was a risk factor, and using preprocedure ocular hypotensives can potentially reduce their occurrence.
authors: *Singapore National Eye Centre and Singapore Eye Research Institute †National University Health Systems ‡Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors: Tian-Loon
authors: TL
authors: Lee
authors: Jamie
authors: J
authors: Yuxin Ng
authors: Monisha E
authors: ME
authors: Nongpiur
authors: Wai-Jia
authors: WJ
authors: Tan
authors: Tin
authors: T
authors: Aung
authors: Shamira A
authors: SA
authors: Perera
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000503:physiopathology / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D032801:Iridectomy / Q000379:methods*; D007498:Iris / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014065:Tonometry, Ocular