title: (M)- and (P)-bicelaphanol A, dimeric trinorditerpenes with promising neuroprotective activity from Celastrus orbiculatus.
abstract: (M)-Bicelaphanol A (1) and (P)-bicelaphanol A (2), two unprecedented dimeric trinorditerpenes existing as atropisomers, together with their monomer celaphanol A (3), were isolated from the root bark of Celastrus orbiculatus. The structures and absolute configurations of 1 and 2 were determined by spectroscopic and single-crystal X-ray diffraction analyses. Compound 1 exhibited a significant in vitro neuroprotective effect against a hydrogen peroxide-induced cell viability decrease in PC12 cells at 1 μM, while compounds 2 and 3 showed such effects at 10 μM.
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
authors: Luo-Yi
authors: LY
authors: Wang
authors: Jian
authors: J
authors: Wu
authors: Zhuo
authors: Z
authors: Yang
authors: Xu-Jie
authors: XJ
authors: Wang
authors: Yan
authors: Y
authors: Fu
authors: Shuang-Zhu
authors: SZ
authors: Liu
authors: Hong-Min
authors: HM
authors: Wang
authors: Wei-Liang
authors: WL
authors: Zhu
authors: Hai-Yan
authors: HY
authors: Zhang
authors: Wei-Min
authors: WM
authors: Zhao
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D029753:Celastraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008968:Molecular Conformation; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D051381:Rats
chemical_list: C582699:(M)-bicelaphanol A; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D000111:Acetylcysteine