title: The 2012 IMB Conference: DNA demethylation, repair and beyond. Institute of Molecular Biology, Mainz, Germany, 18-21 October 2012.
abstract: Headline-grabbing attention has been given to DNA demethylation pathways as new epigenetic mechanisms, with reviews and hypotheses outnumbering research papers. As candidate proteins for DNA demethylation include well-known DNA repair enzymes, it was timely to join epigenetics and DNA repair experts at the first international meeting on DNA Demethylation, Repair and Beyond. New mechanistic insights were presented for known players orchestrating the symphony on cytosine - 'the symphony on C' (TET1, 2, 3; GADD45; AID; and TDG), while new instruments and classical themes were pulled into the amalgamation. What may appear as just an unintentional cacophony of random oxidative lesions and abasic sites in a bed of chromatin noise may turn out to be a gene-expressing regulatory melody.
authors: Epigenetic Editing, Department of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. m.g.rots@umcg.nl
authors: Marianne G
authors: MG
authors: Rots
authors: Svend K
authors: SK
authors: Petersen-Mahrt
mesh_terms: D002843:Chromatin / Q000235:genetics; D018899:CpG Islands / Q000235:genetics; D004247:DNA / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D005858:Germany; D006801:Humans
chemical_list: D002843:Chromatin; D004247:DNA