title: Nanoformulated antibiotics: the next step for pathogenic bacteria control.
abstract: The resistance of infectious bacteria to current antibiotics is a worldwide problem. Previous studies have demonstrated the efficacy of nanostructured molecules against pathogens as an innovative methodology for the development of novel drugs. Currently, 95% of properties limited pharmacies applicability such as low solubility, short half-life in the circulatory system, toxicity associated to controlled release and immunogenicity. Furthermore, nanobiotechnology provides a different perspective for modifying these properties and allows innovative drug development. In this context, this review aims to describe different methods, polymers, and drugs used to obtain and analyze nanostructures associated with antibiotics as an unconventional and innovative tool for bacterial control. Biotechnology provides a different perspective for modifying drug properties and allows innovative drug development. This review describes nanostructures in association with antibiotics as an unconventional and innovative tool for bacterial control.
authors: Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasilia, DF, Brasil.
authors: Amanda Caroline Marques
authors: AC
authors: Saúde
authors: Mariana Dornelles
authors: MD
authors: Cherobim
authors: André Corrêa
authors: AC
authors: Amaral
authors: Simoní Campos
authors: SC
authors: Dias
authors: Octávio Luiz
authors: OL
authors: Franco
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D011108:Polymers / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D004337:Drug Carriers; D011108:Polymers