title: Mean platelet volume in patients with nasal polyposis.
abstract: OBJECTIVE
  To investigate whether mean platelet volume (MPV) levels rise in patients with nasal polyposis (NP) and whether higher MPV levels are correlated to the extension of polyps in these patients.
  
  
  METHODS
  This study included 50 patients with NP and 40 age- and sex-matched healthy subjects as controls. The Lund-Mackay staging system was used to assess paranasal sinus computed tomography (CT) scans in patients with NP, and paranasal sinus CT scores were recorded. MPV was measured in a blood sample collected in EDTA tubes and was also used for whole blood counts in all patients. The Mann-Whitney U-test and Student's t-test were used to compare the results of the two groups.
  
  
  RESULTS
  NP patients had higher MPV levels than the control group (9.60 +/- 1.06 fl and 8.77 +/- 0.88 fl, p < 0.001 respectively). However, there was no significant correlation between MPV and paranasal sinus CT scores.
  
  
  CONCLUSIONS
  To our knowledge, this is the first study to investigate MPV levels in patients with NP. Our results suggest that MPV, a determinant of platelet activation, is elevated in patients with NP. Increased platelet activation may be related to an increase in cardiovascular risk in patients with NP.
authors: Department of ENT, Kayseri Training and Research Hospital. musagit@yahoo.com
authors: M
authors: M
authors: Sagit
authors: S
authors: S
authors: Cetinkaya
authors: M
authors: M
authors: Dogan
authors: A
authors: A
authors: Bayram
authors: U E
authors: UE
authors: Vurdem
authors: M A
authors: MA
authors: Somdas
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D001810:Blood Volume; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009298:Nasal Polyps / Q000503:physiopathology*; D015539:Platelet Activation / Q000502:physiology; D010976:Platelet Count