title: Synthesis of nordihydroguaiaretic acid derivatives and their bioactivities on S. pombe and K562 cell lines.
abstract: Nordihydroguaiaretic acid (NDGA) and its synthetic analogues are potentially useful in treating diseases related to cancers, diabetes, viral and bacterial infections, and inflammation. In this paper, we report the optimal synthetic methods and the bioactivity study of terameprocol 2, NDGA derivative 3, and its cyclized analogue 4. The IC50 of these three compounds 2, 3 and 4 on the growth metabolism of Schizosacchromyces pombe and K562 cell lines were determined by microcalorimetry. The preliminary results showed that the compounds 2, 3 and 4 possessed good inhibition activities on S. pombe and K562 cell lines, and exhibited bidirectional biological effect and Hormesis effect. In particular, terameprocol 2 was found to possess the most potent inhibitory effect on K562 cell lines.
authors: Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds and Applications, Department of Chemistry and Life Science, Xiangnan University, Chenzhou 423000, Hunan Province, PR China.
authors: Xu
authors: X
authors: Li
authors: Jian-Hong
authors: JH
authors: Jiang
authors: Qingqi
authors: Q
authors: Chen
authors: Sheng-Xiong
authors: SX
authors: Xiao
authors: Chuan-Hua
authors: CH
authors: Li
authors: Hui-Wen
authors: HW
authors: Gu
authors: Hui
authors: H
authors: Zhang
authors: Ji-Lin
authors: JL
authors: Hu
authors: Fei-Hong
authors: FH
authors: Yao
authors: Qiang-Guo
authors: QG
authors: Li
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020014:K562 Cells; D009637:Masoprocol / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012568:Schizosaccharomyces / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000935:Antifungal Agents; D009637:Masoprocol