title: Nanocrystalline nickel ferrite particles synthesized by non-hydrolytic sol-gel method and their composite with biodegradable polymer.
abstract: Targeted drug delivery has been one of the most important biomedical applications for magnetic particles. Such applications require magnetic particles to have functionalized surfaces/surface coatings that facilitate their incorporation into a polymer matrix to produce a polymer composite. In this paper, nanocrystalline nickel ferrite particles with an oleic acid surface coating were synthesized using a non-hydrolytic sol-gel method and incorporated into a biodegradable polymer matrix, poly(D,L-lactide) PLA prepared using a double emulsion method. As-synthesized nickel ferrite particles had a multi-crystalline structure with chemically adsorbed oleic acid on their surface. After forming the PLA composite, nickel ferrite particles were encapsulated in PLA microspheres. At low nickel ferrite concentrations, composites showed very similar surface charges to that of PLA. The composites were magnetically responsive and increasing the nickel ferrite concentration was found to increase magnetization of the composite.
authors: Division of Materials Science and Engineering, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Private Bag 33 Clayton, Victoria 3169, Australia.
authors: H
authors: H
authors: Yin
authors: P S
authors: PS
authors: Casey
authors: G M
authors: GM
authors: Chow
mesh_terms: D020341:Absorbable Implants; D001704:Biopolymers / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D005290:Ferric Compounds / Q000138:chemical synthesis*; D006868:Hydrolysis; D018189:Immunomagnetic Separation / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D009532:Nickel; D010316:Particle Size; D044367:Phase Transition; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001704:Biopolymers; D005290:Ferric Compounds; D046911:Macromolecular Substances; D053769:Nanocapsules; D011091:Polyesters; C550717:nickel ferrite; C033616:poly(lactide); D009532:Nickel