title: The effect of calcium silicate on in vitro physiochemical properties and in vivo osteogenesis, degradability and bioactivity of porous β-tricalcium phosphate bioceramics.
abstract: Porous β-tricalcium phosphate(TCP)/calcium silicate(CS) composite bioceramics with different weight proportions were prepared to investigate the in vitro effects of CS on the physiochemical properties of TCP and the in vivo effects of CS on the degradability, osteogenesis and bioactivity of TCP. The physiochemical results showed that the addition of CS to porous TCP resulted in a looser and rougher surface and a lower solid density, compressive strength and Young's modulus and a lower pH value as compared to pure CS without any chemical interaction between the TCP and the CS. The in vivo study showed that the material degradation of porous TCP/CS composite bioceramics was slower than that of pure CS, although the osteogenesis, degradability and bioactivity were significantly increased in the long term. Thereafter, the introduction of CS into porous TCP bioceramics is an effective way to prepare bioactive bone grafting scaffolds for clinical use and to control properties such as in vivo degradability and osteoinduction of TCP.
authors: Department of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, 600 Yishan Road, Shanghai 200233, People's Republic of China.
authors: Shen
authors: S
authors: Liu
authors: Fangchun
authors: F
authors: Jin
authors: Kaili
authors: K
authors: Lin
authors: Jianxi
authors: J
authors: Lu
authors: Jiao
authors: J
authors: Sun
authors: Jiang
authors: J
authors: Chang
authors: Kerong
authors: K
authors: Dai
authors: Cunyi
authors: C
authors: Fan
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis*; D017610:Calcium Compounds / Q000737:chemistry*; D002130:Calcium Phosphates; D002516:Ceramics / Q000138:chemical synthesis; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005264:Femoral Fractures / Q000473:pathology* / Q000601:surgery*; D008422:Materials Testing; D010012:Osteogenesis / Q000502:physiology*; D016062:Porosity; D011817:Rabbits; D017640:Silicates / Q000737:chemistry*; D054457:Tissue Scaffolds; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D017610:Calcium Compounds; D002130:Calcium Phosphates; D017640:Silicates; C485817:beta-tricalcium phosphate; C031293:calcium silicate