title: Severe hepatic necrosis of unknown causes following ABO-incompatible liver transplantation.
abstract: Emergency ABO-incompatible (ABO-I) liver transplantations (LTx) have been performed increasingly to treat severe liver failure. Herein, we report a case of severe hepatic necrosis after ABO-I LTx. A 53-year-old man with blood group O was diagnosed as having severe hepatitis B and acute-on-chronic liver failure, and underwent an emergency liver transplantation implanting a blood-group-B liver from a cardiac-death donor. A routine anti-rejection, anti-infection and anti-virus therapy was given after operation. On post-operative day (POD) 16, the recipient had fever and erythra. Laboratory and radiographic examinations suggested a severe hepatic necrosis of unknown causes. The patient was managed with a 10-d methylprednisolone pulse therapy. He was discharged on POD 35 with stable condition, and no recurrent disease was found during the follow-up.
authors: Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors: Hao
authors: H
authors: Lu
authors: Chuan-Yong
authors: CY
authors: Zhang
authors: Wei
authors: W
authors: Ding
authors: Yun-Jie
authors: YJ
authors: Lu
authors: Guo-Qiang
authors: GQ
authors: Li
authors: Feng
authors: F
authors: Zhang
authors: Ling
authors: L
authors: Lu
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D001787:Blood Group Incompatibility / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008107:Liver Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009336:Necrosis; D020551:Pulse Therapy, Drug; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000017:ABO Blood-Group System; D007166:Immunosuppressive Agents; D008775:Methylprednisolone
keywords: ABO-incompatible; Graft rejection; Hepatic necrosis; Liver transplantations; Pulse therapy