title: Insulin resistance and lipid accumulation product in corelation to body mass index in women with polycystic ovary syndrome.
abstract: BACKGROUND
  Women with Polycystic Ovary Syndrome (PCOS) are at increased risk for cardiovascular morbidity and metabolic disorders including: dyslipidaemia, hypertension, insulin resistance, gestational diabetes, type 2 diabetes, systemic inflammation and endothelial dysfunction. The prevalence of obesity and insulin resistance in women with PCOS is significantly higher compared to the general population. Lipid accumulation product is a new, cheap and easily available predictor for metabolic syndrome both in general population and in women with PCOS.
  
  
  METHODS
  The study included 50 patients at the Clinic of Endocrinology, Diabetes and Metabolic Disorders, Clinical Center University of Sarajevo. All patients were diagnosed with PCOS according to the Rotterdam ESHRE criteria and were divided into two groups according to their body mass index (BMI). A prospective study established the following parameters: anthropometric measurements (waist circumference, height, weight), BMI, and serum triglycerides and insulin resistance. LAP was calculated using the formula: LAP (women) = [waist circumference (cm)-58] x [triglycerides (mmol/L)].
  
  
  RESULTS
  Waist circumference in women with BMI < or = 24.9 kg/m2 was 31 cm lower than waist circumference in women with a BMI > 25 kg/m2. Mean triglyceride value of the patients in group BMI < or = 24.9 kg/m2 was 1.15 mmol/l lower than the mean value of triglycerides in women with a BMI > 25 kg/m2. Insulin resistance was present in 66.7% in group with BMI < or = 24.9 kg/m2, and in 75.0% in the group with BMI > 25.0 kg/m2. LAP was shown to be a marker for the differentiation of insulin-resistant and nonresistant patients with a cut-off value of 17.91.
  
  
  CONCLUSIONS
  Patients with PCOS and BMI < or = 24.9 kg/m2 were significantly different from those with BMI > 25 kg/m2 in the values of body weight, waist circumference and triglycerides. There was no statistically significant difference in insulin resistance. LAP values were higher in patients in the group with BMI > 25 kg/m2. LAP was a marker for differentiation of insulin--resistant and non-resistant women with PCOS.
authors: Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Center, University of Sarajevo, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina. godinjakamina@gmail.com
authors: Amina
authors: A
authors: Godinjak
authors: Zulfo
authors: Z
authors: Godinjak
authors: Azra
authors: A
authors: Burekovic
authors: Ismana
authors: I
authors: Surkovic
authors: Amela
authors: A
authors: Dizdarevic-Bostandzic
authors: Zelija
authors: Z
authors: Velija-Asimi
mesh_terms: D015992:Body Mass Index; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference
chemical_list: D014280:Triglycerides