title: Physicochemical studies and biological evaluation on (E)-3-(2-(1-(2-hydroxyphenyl)hydrazinyl)-3-oxo-N-(thiazol-2yl)propanamide complexes.
abstract: Hydrazone complexes of Co(II), Ni(II), Cu(II), Pd(II), Cd(II), Zn(II) and U(VI)O2 with (E)-3-(2-(1-(2-hydroxyphenyl)hydrazinyl)-3-oxo-N-(thiazol-2yl)propanamide (H2o-HAH) have been synthesized. The complex structure has been elucidated by analysis (elemental and thermal), spectroscopy ((1)H NMR, (13)C NMR, IR, UV-visible, ESR, MS) and physical measurements (magnetic susceptibility and molar conductance). The kinetic and thermodynamic parameters for the different decomposition steps of some complexes have been calculated using the Coats-Redfern equation. Also, the association and formation constants of Co(II) ion in absolute ethanol solutions at 294.15K have been calculated by using electrical conductance. Moreover, the ligand and its complexes have been screened for their antibacterial (Escherichia coli and Clostridium sp.) and antifungal activities (Aspergillus sp. and Stemphylium sp.) by MIC method.
authors: Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.
authors: K M
authors: KM
authors: Ibrahim
authors: R R
authors: RR
authors: Zaky
authors: E A
authors: EA
authors: Gomaa
authors: M N
authors: MN
authors: Abd El-Hady
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001228:Aspergillosis / Q000188:drug therapy; D001230:Aspergillus / Q000187:drug effects; D003013:Clostridium / Q000187:drug effects; D003015:Clostridium Infections / Q000188:drug therapy; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004553:Electric Conductivity; D004578:Electron Spin Resonance Spectroscopy; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011407:Propane / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013816:Thermodynamics; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000577:Amides; D000890:Anti-Infective Agents; D056831:Coordination Complexes; D006835:Hydrazones; D012545:Schiff Bases; D013844:Thiazoles; D011407:Propane