title: Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1.
abstract: The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated by alleviated lung pathological changes and infiltration of proteins and leukocytes. In addition, PD inhibited CLP-induced serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production, lung cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) protein expressions and NF-κB activation. Notably, PD upregulated the expression and activity of heme oxygenase (HO-)1 in lung tissue of septic mice. Further, the protective effects of PD on sepsis were abrogated by ZnPP IX, a specific HO-1 inhibitor. These findings indicated that PD might be an effective antisepsis drug.
authors: Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China.
authors: Xiao-hui
authors: XH
authors: Li
authors: Xia
authors: X
authors: Gong
authors: Li
authors: L
authors: Zhang
authors: Rong
authors: R
authors: Jiang
authors: Hong-zhong
authors: HZ
authors: Li
authors: Meng-jiao
authors: MJ
authors: Wu
authors: Jing-yuan
authors: JY
authors: Wan
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D005960:Glucosides / Q000627:therapeutic use*; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood; D055370:Lung Injury / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology*; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D011897:Random Allocation; D018805:Sepsis / Q000097:blood / Q000201:enzymology* / Q000378:metabolism*; D013267:Stilbenes / Q000627:therapeutic use*; D051996:Transcription Factor RelA / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D005960:Glucosides; D015850:Interleukin-6; D013267:Stilbenes; D051996:Transcription Factor RelA; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D051547:Heme Oxygenase-1; C058229:polydatin