title: A viable therapeutic option: mechanical circulatory support of the failing Fontan physiology.
abstract: A blood pump specifically designed to augment flow from the great veins through the lungs would ameliorate the poor physiology of the failing univentricular circulation and result in a paradigm shift in the treatment strategy for Fontan patients. This study is the first to examine mechanical cavopulmonary assistance with a blood pump in the inferior vena cava (IVC) and hepatic blood flow. Five numerical models of mechanical cavopulmonary assistance were investigated using a three-dimensional, reconstructed, patient-specific Fontan circulation from magnetic resonance imaging data. Pressure flow characteristics of the axial blood pump, energy augmentation calculations for the cavopulmonary circulation with and without pump support, and hemolysis estimations were determined. In all of the pump-supported scenarios, a pressure increase of 7-9.5 mm Hg was achieved. The fluid power of the cavopulmonary circulation was also positive over the range of flow rates. No retrograde flow from the IVC into the hepatic circulation was evident during support cases. Vessel suction risk, however, was found for greater operating rotational speeds. Fluid shear stresses and hemolysis predictions remained at acceptable levels with normalized index of hemolysis estimations at 0.0001 g/100 L. The findings of this study support the continued design and development of this blood pump technology for Fontan patients with progressive cardiovascular insufficiency. Validation of these flow and performance predictions will be completed in the next round of experimental testing with blood bag evaluation.
authors: BioCirc Research Laboratory, Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, 401 West Main Street, Rm. E3221, Richmond, VA 23284, USA. althrock@vcu.edu
authors: Amy L
authors: AL
authors: Throckmorton
authors: Sergio
authors: S
authors: Lopez-Isaza
authors: Emily A
authors: EA
authors: Downs
authors: Steven G
authors: SG
authors: Chopski
authors: James J
authors: JJ
authors: Gangemi
authors: William
authors: W
authors: Moskowitz
mesh_terms: D001243:Assisted Circulation / Q000295:instrumentation*; D003198:Computer Simulation; D004867:Equipment Design; D018729:Fontan Procedure / Q000295:instrumentation*; D006330:Heart Defects, Congenital / Q000601:surgery*; D006352:Heart Ventricles / Q000601:surgery*; D006801:Humans; D008955:Models, Cardiovascular