title: Effects of food or sleep deprivation during civilian survival training on clinical chemistry variables.
abstract: OBJECTIVE
  To describe clinical chemistry and weight changes after short-term food or sleep deprivation or multiple deprivations during civilian survival training.
  
  
  METHODS
  Data from one baseline-controlled two-period crossover study designed to compare sleep deprivation for up to 50 hours with food deprivation for up to 66 hours (n = 12) and data from regular multiple-deprivations survival training comparing participants (n = 33) with nondeprived instructors (n = 10).
  
  
  RESULTS
  Food deprivation was associated with decreased body weight, blood glucose, serum triglycerides, sodium, chloride, and urine pH, and there were increases in blood and urine ketones and serum free fatty acids. Sleep deprivation was associated with a minor decrease in hemoglobin and erythrocyte particle count and volume fraction and an increase in leukocytes.
  
  
  CONCLUSIONS
  The clinical chemistry and body weight changes associated with food deprivation were qualitatively similar to those observed in fasting obese patients but developed quicker in the survival training setting. Sleep deprivation had few effects on the clinical chemistry profile except for hematological variables. Physicians evaluating clinical chemistry data from patients subjected to short-term food or sleep deprivation should take the physiological state into account in their assessment.
authors: Department of Clinical Pharmacology, Karolinska University Hospital at Huddinge, Karolinska Institute, Huddinge, Sweden. lars.stahle@telia.com
authors: Lars
authors: L
authors: Ståhle
authors: Elisabeth
authors: E
authors: Granström
authors: Ewa
authors: E
authors: Ljungdahl Ståhle
authors: Sven
authors: S
authors: Isaksson
authors: Anders
authors: A
authors: Samuelsson
authors: Mats
authors: M
authors: Rudling
authors: Harry
authors: H
authors: Sepp
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D018592:Cross-Over Studies; D005260:Female; D005508:Food Deprivation / Q000502:physiology*; D006403:Hematologic Tests; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D012892:Sleep Deprivation / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D016482:Urinalysis; D055815:Young Adult
chemical_list: D001786:Blood Glucose