title: Chalcones from the flowers of Coreopsis lanceolata and their in vitro antioxidative activity.
abstract: Three new chalcones, 3,2'-dihydroxy-4,3'-dimethoxychalcone-4'-glucoside (1), 4'-O-(2'''-O-caffeoyl)2',3',3,4-tetrahydroxychalcone (2), and 2',4',3-trihydroxy-3',4-dimethoxychalcone (3), along with five known phenolics, were isolated from Coreopsis lanceolata flowers. The structures of the new compounds were elucidated by extensive spectroscopic methods including NMR and MS. The three new chalcones showed a good in vitro HepG2 cell protecting effect against tert-butylhydroperoxide-induced oxidative stress.
authors: Functional Food Center, KIST Gangneung Institute, Gangwon, Korea.
authors: Ya Fang
authors: YF
authors: Shang
authors: Sarangerel
authors: S
authors: Oidovsambuu
authors: Je-Seung
authors: JS
authors: Jeon
authors: Chu Won
authors: CW
authors: Nho
authors: Byung-Hun
authors: BH
authors: Um
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031945:Coreopsis / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D035264:Flowers / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D020122:tert-Butylhydroperoxide / Q000494:pharmacology
chemical_list: C585809:2',4',3-trihydroxy-3',4-dimethoxychalcone; C585807:3,2'-dihydroxy-4,3'-dimethoxychalcone-4'-glucoside; C585808:4'-O-(2'''-O-caffeoyl)2',3',3,4-tetrahydroxychalcone; D000975:Antioxidants; D047188:Chalcones; D016166:Free Radical Scavengers; D005960:Glucosides; D020122:tert-Butylhydroperoxide