title: Developments in virus-like particle-based vaccines for HIV.
abstract: Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4(+) T-helper and CD8(+) cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.
authors: Department of Experimental Oncology, Molecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori 'Fond Pascale', Via Mariano Semmola 142, 80131 Napoli, Italy.
authors: Luigi
authors: L
authors: Buonaguro
authors: Maria
authors: M
authors: Tagliamonte
authors: Maria Luisa
authors: ML
authors: Visciano
authors: Maria Lina
authors: ML
authors: Tornesello
authors: Franco M
authors: FM
authors: Buonaguro
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D000956:Antigens, Viral / Q000276:immunology; D035843:Biomedical Research / Q000639:trends; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D058425:Vaccines, Virus-Like Particle / Q000276:immunology* / Q000302:isolation & purification*
chemical_list: D016915:AIDS Vaccines; D000956:Antigens, Viral; D058425:Vaccines, Virus-Like Particle