title: Increased serum cholesterol esterification rates predict coronary heart disease and sudden death in a general population.
abstract: OBJECTIVE
  Lecithin:cholesterol acyltransferase (LCAT) is thought to be important in reverse cholesterol transport. However, its association with coronary heart disease (CHD) and sudden death is controversial.
  
  
  RESULTS
  We prospectively studied 1927 individuals from the general population. Serum concentrations of apolipoprotein A-I, A-II, B, C-II, C-III, E, and LCAT activity measured as a serum cholesterol esterification rate were evaluated. We documented 61 events of CHD and sudden death during 10.9 years of follow-up. After adjustment for age and sex, LCAT activity was significantly associated with the risk of CHD and sudden death (hazard ratio, 3.02; 95% confidence interval, 1.49-6.12; P=0.002). In multivariate analysis adjusted for age, sex, current smoking status, history of diabetes mellitus, body mass index, systolic blood pressure, serum total cholesterol, and serum high-density lipoprotein cholesterol concentrations, the hazard ratio of LCAT activity for the risk of CHD and sudden death remained significant (hazard ratio, 3.07; 95% confidence interval, 1.35-7.01; P=0.008). However, when it was analyzed for men and women separately, this association remained significant only in women.
  
  
  CONCLUSIONS
  Increased LCAT activity measured as a serum cholesterol esterification rate was a risk for CHD and sudden death in a Japanese general population.
authors: Department of Internal Medicine, Toyooka Hospital Hidaka Medical Center, 81 Iwanaka, Hidaka-cho, Toyooka 669-5392, Japan. shintanaka12@gmail.com
authors: Shin-ichiro
authors: S
authors: Tanaka
authors: Tomoyuki
authors: T
authors: Yasuda
authors: Tatsuro
authors: T
authors: Ishida
authors: Yoshio
authors: Y
authors: Fujioka
authors: Takeshi
authors: T
authors: Tsujino
authors: Tetsuo
authors: T
authors: Miki
authors: Ken-ichi
authors: K
authors: Hirata
mesh_terms: D000328:Adult; D000368:Aged; D002788:Cholesterol Esters / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D003645:Death, Sudden / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism; D011446:Prospective Studies; D012727:Sex Characteristics
chemical_list: D002788:Cholesterol Esters; D007862:Phosphatidylcholine-Sterol O-Acyltransferase