title: Use of bioresorbable membranes to reduce abdominal and perihepatic adhesions in 2-stage hepatectomy of liver metastases from colorectal cancer: results of a prospective, randomized controlled phase II trial.
abstract: OBJECTIVE
  To assess by prospective randomized controlled trial the feasibility and efficacy of using a bioresorbable hyaluronic acid/carboxymethylcellulose membrane (HA membrane) to prevent abdominal and perihepatic adhesions in metastatic colorectal cancer patients requiring 2-stage hepatectomy.
  
  
  BACKGROUND
  Two-stage hepatectomy offers the possibility of long-term survival to selected patients whose liver metastases cannot be removed in a single procedure. However, the second operation is made more difficult by adhesions arising from the first. HA membrane reduces adhesions in gynecologic and abdominal surgery but this is the first trial in hepatectomy.
  
  
  METHODS
  Fifty-four candidates for 2-stage hepatectomy were randomized at the end of the first procedure to implantation of HA membrane (n = 41) or standard management (n = 13). Thirty patients from the membrane arm and 11 well-matched controls underwent the planned second hepatectomy.
  
  
  RESULTS
  Positioning of the HA membranes was feasible in all but one patient and did not increase complications associated with the first hepatectomy. At second hepatectomy, patients in the HA membrane arm required 33% less time than controls to achieve complete liver mobilization (median: 50 vs 75 minutes; primary endpoint). The risk of extensive adhesions was reduced in the HA membrane group (31% had grade 3-4 adhesions vs 55% in controls), as was adhesion severity (17% thick and hypervascular adhesions vs 46%). The proportion of patients with complications at second hepatectomy was higher in the control group (55% vs 23% in the HA membrane group, P = 0.07).
  
  
  CONCLUSIONS
  Use of 4 HA membranes at the end of first hepatectomy reduced the extent and severity of adhesions and facilitated the second hepatectomy in patients with liver metastases who required a 2-stage hepatectomy. A larger study to confirm these findings is warranted. (NCT01262417).
authors: Léon Bérard Cancer Center, Lyon, France.
authors: Aurélien
authors: A
authors: Dupré
authors: Anne
authors: A
authors: Lefranc
authors: Emmanuel
authors: E
authors: Buc
authors: Jean Robert
authors: JR
authors: Delpero
authors: François
authors: F
authors: Quenet
authors: Guillaume
authors: G
authors: Passot
authors: Serge
authors: S
authors: Evrard
authors: Michel
authors: M
authors: Rivoire
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D002266:Carboxymethylcellulose Sodium; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D006820:Hyaluronic Acid; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011446:Prospective Studies; D012086:Reoperation; D015996:Survival Rate; D000267:Tissue Adhesions / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D008567:Membranes, Artificial; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium