title: Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
abstract: A series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which compounds 1, 5, 6, 20, 27 and 34 exhibited significantly higher activity against TMV than commercial Ribavirin both in vitro and in vivo. Furthermore, these compounds have more simple structure than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.
authors: State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China.
authors: Meng
authors: M
authors: Wu
authors: Ziwen
authors: Z
authors: Wang
authors: Chuisong
authors: C
authors: Meng
authors: Kailiang
authors: K
authors: Wang
authors: Yanna
authors: Y
authors: Hu
authors: Lizhong
authors: L
authors: Wang
authors: Qingmin
authors: Q
authors: Wang
mesh_terms: D000179:Acrylates / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology; D002934:Cinnamates / Q000737:chemistry / Q000494:pharmacology; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D054884:Host-Pathogen Interactions / Q000187:drug effects*; D008956:Models, Chemical; D015394:Molecular Structure; D018515:Plant Leaves / Q000821:virology; D012254:Ribavirin / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014026:Nicotiana / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects* / Q000502:physiology; D014641:Vanillic Acid / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000179:Acrylates; D000998:Antiviral Agents; D002109:Caffeic Acids; D002934:Cinnamates; D003373:Coumaric Acids; C029010:cinnamic acid; D012254:Ribavirin; C004999:ferulic acid; D014641:Vanillic Acid; C036658:acrylic acid; C040048:caffeic acid