title: Role of β-Catenin in regulating the balance between TNF-α- and Fas-induced acute liver injury.
abstract: β-Catenin plays many critical roles during various liver physiological and pathological processes. However, the role of β-Catenin in acute liver failure remains unclear. Using hepatocyte specific β-Catenin knockout mice, we found that loss of β-Catenin in hepatocyte significantly reduced GalN/LPS-induced liver damage and hepatocyte apoptosis, but exacerbated Jo2-mediated liver injury. Mechanistically, the dual effects of β-Catenin attributes on its function of inhibiting NF-κB signaling, which aggravates oxidative stress but decreases Fas expression under injury conditions. In conclusion, β-Catenin plays an important role in regulating the balance between TNF-α and Fas-induced liver injury via its effect on NF-κB.
authors: International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute/Hospital, 225 Changhai Road, Shanghai 200438, PR China.
authors: Shan-Shan
authors: SS
authors: Zou
authors: Wen
authors: W
authors: Yang
authors: He-Xin
authors: HX
authors: Yan
authors: Le-Xing
authors: LX
authors: Yu
authors: Yu-Qiong
authors: YQ
authors: Li
authors: Fu-Quan
authors: FQ
authors: Wu
authors: Liang
authors: L
authors: Tang
authors: Yan
authors: Y
authors: Lin
authors: Lin-Na
authors: LN
authors: Guo
authors: Hua-Bang
authors: HB
authors: Zhou
authors: Dong-Xun
authors: DX
authors: Zhou
authors: Feng
authors: F
authors: Shen
authors: Meng-Chao
authors: MC
authors: Wu
authors: He-Ping
authors: HP
authors: Hu
authors: Hong-Yang
authors: HY
authors: Wang
mesh_terms: D055371:Acute Lung Injury / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D017209:Apoptosis; D001219:Aspartate Aminotransferases / Q000097:blood; D045744:Cell Line, Tumor; D055786:Gene Knockout Techniques; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*; D051176:beta Catenin / Q000502:physiology*; D019014:fas Receptor / Q000502:physiology*
chemical_list: C495267:CTNNB1 protein, mouse; C491899:Fas protein, mouse; D008070:Lipopolysaccharides; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D051176:beta Catenin; D019014:fas Receptor; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase