title: Ovarian aging: breaking up is hard to fix.
abstract: Accumulation of double-stranded DNA breaks and inhibition of DNA repair contributes to reproductive aging by diminishing ovarian reserves in mice and women.
authors: Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA. josh.johnson@yale.edu
authors: Joshua
authors: J
authors: Johnson
authors: David L
authors: DL
authors: Keefe
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D019313:BRCA1 Protein / Q000378:metabolism*; D016922:Cellular Senescence; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D005260:Female; D006801:Humans; D009865:Oocytes / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism*
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human