title: Successful treatment of severe hepatorenal syndrome with living donor liver transplantation.
abstract: Hepatorenal syndrome is defined as renal failure caused by acute or chronic liver failure without any laboratory or histological reasons. The exact etiology of this syndrome is unknown. However, vasodilatation in the splanchnic area as a result of cirrhosis and portal hypertension, reflex systemic and splanchnic vasoconstriction are the basic pathophysiological reasons of this syndrome. The decrease of renal perfusion, decrease in glomerular filtration rate, sodium retention and deterioration of excretion of free water are the major renal problems and these remain progressive according to the stage of liver disease. The treatment of this syndrome is correction of the underlying problem. Here, we report a patient who was having hemodialysis due to renal failure as a consequence of liver cirrhosis for three months and returned back to his normal life without a need for dialysis after liver transplantation.
authors: Department of Organ Transplantation, Sisli Florence Nightingale Hospital, Sisli, Istanbul, Turkey. tolgademirbas@yahoo.com
authors: Baha Tolga
authors: BT
authors: Demirbas
authors: Turgut
authors: T
authors: Piskin
authors: Murat
authors: M
authors: Dayangac
authors: Onur
authors: O
authors: Yaprak
authors: Levent
authors: L
authors: Oklu
authors: Yildiray
authors: Y
authors: Yuzer
authors: Yaman
authors: Y
authors: Tokat
mesh_terms: D006530:Hepatorenal Syndrome / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000209:etiology / Q000628:therapy; D012720:Severity of Illness Index; D016896:Treatment Outcome