title: Ocular hemodynamics and glaucoma: the role of mathematical modeling.
abstract: OBJECTIVE
  To discuss the role of mathematical modeling in studying ocular hemodynamics, with a focus on glaucoma.
  
  
  METHODS
  We reviewed recent literature on glaucoma, ocular blood flow, autoregulation, the optic nerve head, and the use of mathematical modeling in ocular circulation.
  
  
  RESULTS
  Many studies suggest that alterations in ocular hemodynamics play a significant role in the development, progression, and incidence of glaucoma. Although there is currently a limited number of studies involving mathematical modeling of ocular blood flow, regulation, and diseases (such as glaucoma), preliminary modeling work shows the potential of mathematical models to elucidate the mechanisms that contribute most significantly to glaucoma progression.
  
  
  CONCLUSIONS
  Mathematical modeling is a useful tool when used synergistically with clinical and laboratory data in the study of ocular blood flow and glaucoma. The development of models to investigate the relationship between ocular hemodynamic alterations and glaucoma progression will provide a unique and useful method for studying the pathophysiology of glaucoma.
authors: Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, USA. alharris@indiana.edu
authors: Alon
authors: A
authors: Harris
authors: Giovanna
authors: G
authors: Guidoboni
authors: Julia C
authors: JC
authors: Arciero
authors: Annahita
authors: A
authors: Amireskandari
authors: Leslie A
authors: LA
authors: Tobe
authors: Brent A
authors: BA
authors: Siesky
mesh_terms: D001783:Blood Flow Velocity; D005123:Eye / Q000098:blood supply*; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008962:Models, Theoretical; D009898:Optic Disk / Q000098:blood supply; D009901:Optic Nerve Diseases / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology*