title: Highly water-soluble platinum(II) complexes as GLUT substrates for targeted therapy: improved anticancer efficacy and transporter-mediated cytotoxic properties.
abstract: Glucose-conjugated malonato-platinum(II) complexes are designed and synthesized to target tumor-specific active transporters, namely, glucose transporters (GLUTs); the complexes exhibit much higher aqueous solubility by 150 times, improved potency in cytotoxicities by 10 times, and increased therapeutic index by over 30 fold compared to the newest generation of clinical drugs oxaliplatin.
authors: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. China.
authors: Pengxing
authors: P
authors: Liu
authors: Yanhui
authors: Y
authors: Lu
authors: Xiangqian
authors: X
authors: Gao
authors: Ran
authors: R
authors: Liu
authors: Daisy
authors: D
authors: Zhang-Negrerie
authors: Ying
authors: Y
authors: Shi
authors: Yiqiang
authors: Y
authors: Wang
authors: Songqing
authors: S
authors: Wang
authors: Qingzhi
authors: Q
authors: Gao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D005947:Glucose / Q000737:chemistry; D051246:Glucose Transport Proteins, Facilitative / Q000037:antagonists & inhibitors / Q000378:metabolism; D019073:HT29 Cells; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010984:Platinum / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry; D015431:Weight Loss / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D051246:Glucose Transport Proteins, Facilitative; D014867:Water; D010984:Platinum; D005947:Glucose