title: Residual C-peptide in patients with Type 1 diabetes and multiethnic backgrounds.
abstract: OBJECTIVE
  To evaluate serum C-peptide in 88 patients from a multiethnic population with Type-1 diabetes and variable disease durations.
  
  
  METHODS
  Eighty-eight patients with a mean disease duration of 8.1 +7.6 years were included and underwent C-peptide measurement before and after glucagon stimulation. Chi-squared and Mann Whitney U-tests were used to compare the variables between groups (all two-tailed, α = 0.05). Spearmans correlation coefficient was used to test the association between the continuous variables. Logistic regression was used for the multivariate analysis. Twenty-eight (31.8%) individuals had significantly detectable C-peptide levels after stimuli, particularly those with a shorter disease duration (p<0.001).
  
  
  RESULTS
  Patients with detectable C-peptide levels required lower insulin doses (p<0.009) and had similar HbA1C results (p = 0.182) and fewer chronic complications (p = 0.029).
  
  
  CONCLUSIONS
  C-peptide detection was common in Type-1 diabetics, particularly shortly after being diagnosed. This result may have clinical implications.
authors: Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Nutrology Department, Rio de Janeiro/RJ, Brazil.
authors: Mirella Hansen de
authors: MH
authors: Almeida
authors: Joana Rodrigues
authors: JR
authors: Dantas
authors: Bianca
authors: B
authors: Barone
authors: Fabiano Marcel
authors: FM
authors: Serfaty
authors: Rosane
authors: R
authors: Kupfer
authors: Marta
authors: M
authors: Albernaz
authors: Maria Rocio
authors: MR
authors: Bencke
authors: Lenita
authors: L
authors: Zajdenverg
authors: Melanie
authors: M
authors: Rodacki
authors: José Egídio Paulo de
authors: JE
authors: Oliveira
mesh_terms: D000293:Adolescent; D000328:Adult; D002096:C-Peptide / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology / Q000378:metabolism*; D004812:Epidemiologic Methods; D005260:Female; D005934:Glucagon / Q000494:pharmacology; D006801:Humans; D049449:Luminescence; D008297:Male; D012737:Sex Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D002096:C-Peptide; D005934:Glucagon