title: Three new norlignans from Glechoma longituba.
abstract: Three new norlignans, glechomols A-C (1-3, respectively), together with a known compound, 4-ethylcatechol (4), were isolated from the ethyl acetate extract of Glechoma longituba (NaKai) Kupr. Their structures were elucidated by the detailed analysis of 1D and 2D NMR and HR-MS data. Glechomols A-C were the first norlignans reported from genus Glechoma, and compound 4 was also isolated from genus Glechoma for the first time. Intracellular antioxidant assays showed that compounds 1-4 displayed significant protective effects on H2O2-induced cardiac cell injury.
authors: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors: Qiu-Fang
authors: QF
authors: Zhu
authors: Yong-Yi
authors: YY
authors: Wang
authors: Wei
authors: W
authors: Jiang
authors: Hai-Bin
authors: HB
authors: Qu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002396:Catechols / Q000737:chemistry / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D019686:Lamiaceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D032383:Myocytes, Cardiac / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats
chemical_list: D000975:Antioxidants; D002396:Catechols; D004365:Drugs, Chinese Herbal; D017705:Lignans; C582450:glechomol A; C582452:glechomol B; C582451:glechomol C; C527200:4-ethylcatechol; D006861:Hydrogen Peroxide