title: Cucurbitane-type triterpenoids from the fruit pulp of Momordica charantia.
abstract: Three new cucurbitane-type triterpenoids, 5beta,19-epoxy-23(R)-methoxycucurbita-6,24-dien-3beta-ol (1), 5beta,19-epoxy-23(S)-methoxycucurbita-6,24-dien-3beta-ol (2), and 3beta-hydroxy-23(R)-methoxycucurbita-6,24-dien-5beta,19-olide (3), were isolated from the fruit pulp of Momordica charantia. Their structures were established on the basis of extensive NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and EI-MS studies. Compound 1 exhibited cytotoxic activity against the SK-Hep 1 cell line.
authors: Department of Food Science, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
authors: Yun-Wen
authors: YW
authors: Liao
authors: Chiy-Rong
authors: CR
authors: Chen
authors: Yueh-Hsiung
authors: YH
authors: Kuo
authors: Jue-Liang
authors: JL
authors: Hsu
authors: Wen-Ling
authors: WL
authors: Shih
authors: Hsueh-Ling
authors: HL
authors: Cheng
authors: Tzou-Chi
authors: TC
authors: Huang
authors: Chi-I
authors: CI
authors: Chang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D002851:Chromatography, High Pressure Liquid; D004396:Coloring Agents; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D029775:Momordica / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013778:Tetrazolium Salts / Q000737:chemistry* / Q000302:isolation & purification; D013844:Thiazoles / Q000737:chemistry* / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: C578737:5beta,19-epoxy-23(R)-methoxycucurbita-6,24-dien-3beta-ol; D004396:Coloring Agents; D004224:Diterpenes; D010936:Plant Extracts; D013778:Tetrazolium Salts; D013844:Thiazoles; D014315:Triterpenes; C022616:thiazolyl blue