title: Current biodefense vaccine programs and challenges.
abstract: The Defense Threat Reduction Agency's Joint Science and Technology Office manages the Chemical and Biological Defense Program's Science and Technology portfolio. The Joint Science and Technology Office's mission is to invest in transformational ideas, innovative people and actionable technology development for Chemical and Biological Defense solutions, with the primary goal to deliver Science and Technology products and capabilities to the warfighter and civilian population that outpace the threat. This commentary focuses on one thrust area within this mission: the Vaccine program of the Joint Science and Technology Office's Translational Medical Division. Here, we will describe candidate vaccines currently in the S&T pipeline, enabling technologies that should facilitate advanced development of these candidates into FDA licensed vaccines, and how the ever-changing biological threat landscape impacts the future of biodefense vaccines.
authors: Defense Threat Reduction Agency; J9-Chemical and Biological Technologies Department; Translational Medical Division; Fort Belvoir, VA USA.
authors: Daniel N
authors: DN
authors: Wolfe
authors: William
authors: W
authors: Florence
authors: Paula
authors: P
authors: Bryant
mesh_terms: D001427:Bacterial Toxins / Q000276:immunology / Q000633:toxicity; D001694:Biological Warfare / Q000517:prevention & control*; D054045:Biological Warfare Agents; D055808:Drug Discovery; D018792:Encephalitis, Viral / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D006482:Hemorrhagic Fevers, Viral / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D006801:Humans; D058873:Pandemics / Q000517:prevention & control*; D014481:United States; D059030:United States Department of Defense; D014612:Vaccines
chemical_list: D001427:Bacterial Toxins; D054045:Biological Warfare Agents; D014612:Vaccines
keywords: Biodefense; Pathogen; Vaccine; alphavirus; anthrax; filovirus; glanders; melioidosis; ricin; tularemia