title: Complications after pancreatic resection: diagnosis, prevention and management.
abstract: BACKGROUND
  Although mortality after pancreaticoduodenectomy (PD) or distal pancreatectomy (DP) has decreased, morbidity still remains high. The aim of this review article is to present, define, predict, prevent, and manage the main complications after pancreatic resection (PR).
  
  
  METHODS
  A non-systematic literature search on morbidity and mortality after PR was undertaken using the PubMed/MEDLINE and Embase databases.
  
  
  RESULTS
  The main complications after PR are delayed gastric emptying (DGE), pancreatic fistula (PF), and bleeding, as defined by the International Study Group on Pancreatic Surgery. PF occurs in 10% to 15% of patients after PD and in 10% to 30% of patients after DP. The different techniques of pancreatic anastomosis and pancreatic remnant closure do not show significant advantages in the prevention of PF, nor does the perioperative use of somatostatin and its analogues. The trend is for conservative or interventional radiology therapy for PF (with enteral nutrition), which achieves a success rate of approximately 80%. DGE after PD occurs in 20% to 50% of patients. Prophylactic erythromycin may reduce the incidence of DGE. Gastric aspiration with erythromycin is usually effective in one to three weeks. Bleeding (gastrointestinal and intraabdominal) occurs in 4% to 16% of patients after PD and in 2% to 3% of patients after DP. Endovascular treatment can only be used for a haemodynamically stable patient. In cases of haemodynamic instability or associated septic complications, surgical treatment is necessary. In expert centres, the mortality rates can be less than 1% after DP and less than 3% after PD.
  
  
  CONCLUSIONS
  There is a need for improved strategies to prevent and treat complications after PR.
authors: Department of Digestive Surgery, CHU Angers, Angers University, Angers, France.
authors: Emilie
authors: E
authors: Lermite
authors: Daniele
authors: D
authors: Sommacale
authors: Tullio
authors: T
authors: Piardi
authors: Jean-Pierre
authors: JP
authors: Arnaud
authors: Alain
authors: A
authors: Sauvanet
authors: Cornelis H C
authors: CH
authors: Dejong
authors: Patrick
authors: P
authors: Pessaux
mesh_terms: D018784:Abdominal Abscess / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D000714:Anastomosis, Surgical / Q000009:adverse effects / Q000379:methods; D001660:Biliary Tract Diseases / Q000209:etiology / Q000628:therapy; D004322:Drainage; D004917:Erythromycin / Q000627:therapeutic use; D005746:Gastric Emptying; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D007511:Ischemia / Q000517:prevention & control; D010180:Pancreatectomy / Q000009:adverse effects* / Q000401:mortality; D010185:Pancreatic Fistula / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D016577:Pancreaticoduodenectomy / Q000009:adverse effects* / Q000401:mortality; D010195:Pancreatitis / Q000175:diagnosis / Q000209:etiology; D019106:Postoperative Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D012086:Reoperation; D012307:Risk Factors
chemical_list: D005765:Gastrointestinal Agents; D004917:Erythromycin