title: Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex.
abstract: A small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymers, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu), was developed in order to provide a tumor acidosis-triggered delivery system with low cytotoxicity.
authors: Institute of Physics, Academia Sinica, Taipei 115, Taiwan.
authors: S-Ja
authors: SJ
authors: Tseng
authors: Yi-Fang
authors: YF
authors: Zeng
authors: Yu-Fan
authors: YF
authors: Deng
authors: Pan-Chyr
authors: PC
authors: Yang
authors: Je-Ruei
authors: JR
authors: Liu
authors: Ivan M
authors: IM
authors: Kempson
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D004573:Electrolytes / Q000737:chemistry / Q000494:pharmacology; D018698:Glutamic Acid / Q000737:chemistry*; D006639:Histidine / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology*; D011094:Polyethyleneimine / Q000737:chemistry / Q000494:pharmacology*; D034741:RNA, Small Interfering / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004573:Electrolytes; D034741:RNA, Small Interfering; D018698:Glutamic Acid; D011092:Polyethylene Glycols; D006639:Histidine; D011094:Polyethyleneimine