title: Highly diastereoselective synthesis of 3-indolylglycines via an asymmetric oxidative heterocoupling reaction of a chiral nickel(II) complex and indoles.
abstract: The asymmetric synthesis of 3-indolylglycine derivatives was achieved by an oxidative heterocoupling reaction. This method for the selective C-3 functionalization of unprotected indoles with the chiral equivalent of a nucleophilic glycine nickel(II) complex afforded adducts with high diastereoselectivities. The decomposition of adducts readily afforded 3-indolylglycine derivatives in high yields.
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China.
authors: Daizong
authors: D
authors: Lin
authors: Jiang
authors: J
authors: Wang
authors: Xu
authors: X
authors: Zhang
authors: Shengbin
authors: S
authors: Zhou
authors: Jie
authors: J
authors: Lian
authors: Hualiang
authors: H
authors: Jiang
authors: Hong
authors: H
authors: Liu
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D007211:Indoles / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D056831:Coordination Complexes; D007211:Indoles; D009532:Nickel; D005998:Glycine