title: Impaired heart rate recovery in patients with endemic fluorosis.
abstract: The objective of the present study was to determine the heart rate recovery index (HRRI), a marker of autonomic nervous system function in patients with endemic fluorosis. Forty patients with endemic fluorosis (16 men/24 women) and 40 age-, sex-, and body mass index-matched healthy controls (16 men/24 women) with normal fluoride intake were enrolled in this study. HRRI was calculated by subtracting the heart rate values at the first, second, and third minutes of the recovery phase from the peak heart rate (HRRI 1, HRRI 2, HRRI 3). Urine fluoride levels of fluorosis patients were significantly (P < 0.001) higher than control subjects as expected. HRRI 2 was significantly lower in fluorosis patients than in the controls. The incidence of abnormal HRRI 1 was significantly higher in fluorosis patients than in the controls (P < 0.05). We observed that HRRI, a marker of autonomic nervous system function, is impaired in patients with chronic fluorosis.
authors: Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors: M Koray
authors: MK
authors: Adali
authors: Ercan
authors: E
authors: Varol
authors: Fatih
authors: F
authors: Aksoy
authors: Atilla
authors: A
authors: Icli
authors: I Hakki
authors: IH
authors: Ersoy
authors: Mehmet
authors: M
authors: Ozaydin
authors: Dogan
authors: D
authors: Erdogan
authors: Abdullah
authors: A
authors: Dogan
mesh_terms: D001341:Autonomic Nervous System / Q000502:physiology*; D015992:Body Mass Index; D016022:Case-Control Studies; D002908:Chronic Disease; D060766:Drinking Water / Q000032:analysis / Q000592:standards; D015150:Echocardiography, Doppler; D019353:Endemic Diseases; D005080:Exercise Test; D005260:Female; D005459:Fluorides / Q000652:urine; D009050:Fluorosis, Dental / Q000503:physiopathology* / Q000652:urine; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D060766:Drinking Water; D005459:Fluorides