title: Potassium 2-(1-hydroxypentyl)-benzoate improves learning and memory deficits in chronic cerebral hypoperfused rats.
abstract: Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB), the pre-drug of 3-n-butylphthalide (dl-NBP), had the significantly therapeutic effect on the acute cerebral ischemia. The present study was to investigate the effect of dl-PHPB on the cognitive deficits induced by chronic cerebral hypoperfusion. Rats were orally administered three doses of dl-PHPB (13, 39 and 129mg/kg), dl-NBP 100mg/kg, and piracetam 600mg/kg daily for 21 days after the bilateral permanent occlusion of the common carotid arteries. The results showed that dl-PHPB, dl-NBP and piracetam significantly improved the spatial learning and memory deficits, and the effectiveness of dl-PHPB at dose of 39mg/kg was strongest. Meanwhile, the drugs decreased superoxide dismutase activity, reduced lipid peroxide and astrocyte activation in the cortex of the hypoperfused rats. Furthermore, dl-PHPB markedly reduced white matter rarefaction. The results indicated that preventing neuropathological alterations, inhibiting oxidative damage and inflammatory reaction might contribute to the improvement of dl-PHPB on hypoperfusion-induced cognitive deficits. Therefore, dl-PHPB has therapeutic potential for the treatment of dementia caused by decrease of cerebral blood flow.
authors: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Wanhong
authors: W
authors: Zhao
authors: Shaofeng
authors: S
authors: Xu
authors: Ying
authors: Y
authors: Peng
authors: Xincai
authors: X
authors: Ji
authors: Dongxu
authors: D
authors: Cao
authors: Jiang
authors: J
authors: Li
authors: Bin
authors: B
authors: Liu
authors: Qiaoqiao
authors: Q
authors: Shi
authors: Ling
authors: L
authors: Wang
authors: Xiaoliang
authors: X
authors: Wang
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications; D001253:Astrocytes / Q000187:drug effects / Q000502:physiology; D001565:Benzoates / Q000494:pharmacology*; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D002340:Carotid Artery Diseases / Q000150:complications; D002908:Chronic Disease; D007859:Learning Disabilities / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D018384:Oxidative Stress / Q000187:drug effects; D010420:Pentanes / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: C511222:2-(1-hydroxypentyl)-benzoate; D001565:Benzoates; D010420:Pentanes