title: Overexpression of SLC7A7 predicts poor progression-free and overall survival in patients with glioblastoma.
abstract: The clinical significance of SLC7A7 expression remains unclear. In this study, we aimed to explore whether SLC7A7 expression in tumor tissues could be used to assess subsequent prognosis in patients with glioblastoma (GBM). A total of 119 patients with pathologically confirmed GBM and 16 normal controls were recruited for this study. The expression of SLC7A7 in GBM and normal tissues was evaluated by immunohistochemistry in tissue microarrays and quantitative real-time PCR. Kaplan-Meier method and Cox's proportional hazards model were used in survival analysis. Compared with normal tissues, GBM specimens had significantly increased expression of SLC7A7 at both mRNA and protein levels (both P < 0.05). Moreover, multivariate analysis confirmed that overexpression of SLC7A7 was a significant and independent indicator for predicting poor prognosis. Our results suggest, for the first time, that overexpression of SLC7A7 is correlated with worse outcomes in patients with GBM. SLC7A7 plays a critical role in GBM carcinogenesis and may be a potential prognosis predictor of GBM.
authors: Department of Neurosurgery, Second Affiliated Hospital of Soochow University, Suzhou, China.
authors: Songhua
authors: S
authors: Fan
authors: Delong
authors: D
authors: Meng
authors: Tao
authors: T
authors: Xu
authors: Yuanyuan
authors: Y
authors: Chen
authors: Jingkun
authors: J
authors: Wang
authors: Xiaoying
authors: X
authors: Li
authors: Hongyan
authors: H
authors: Chen
authors: Daru
authors: D
authors: Lu
authors: Juxiang
authors: J
authors: Chen
authors: Qing
authors: Q
authors: Lan
mesh_terms: D027241:Amino Acid Transport System y+L; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D027301:Fusion Regulatory Protein 1, Light Chains / Q000235:genetics* / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism* / Q000401:mortality* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis
chemical_list: D027241:Amino Acid Transport System y+L; D014408:Biomarkers, Tumor; D027301:Fusion Regulatory Protein 1, Light Chains; C421261:SLC7A7 protein, human