title: Array CGH reveals clonal evolution of adult T-cell leukemia/lymphoma.
abstract: Adult T-cell leukemia/lymphoma (ATLL) is the neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). We performed oligoarray comparative genomic hybridization (CGH) against paired samples comprising peripheral blood (PB) and lymph node (LN) samples from patients with acute-type ATLL. Results disproved the established theory that true monoclonal proliferation, such as identical clonal expansion in all respects, occurred in acute-type ATLL, and our findings revealed that acute-type ATLL contains multiple subclones with differing genomic aberrations. Oligoarray CGH technology has been developed not only for high-resolution application but also for use in various analyses. Our original analysis is a method of identifying two or more clones with different chromosomal aberrations in one sample. Herein, we describe the analysis and clonal evolution of acute-type ATLL.
authors: Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
authors: Akira
authors: A
authors: Umino
authors: Masao
authors: M
authors: Seto
mesh_terms: D015704:CD4 Antigens / Q000032:analysis; D002469:Cell Separation / Q000379:methods; D060965:Clonal Evolution; D055028:Comparative Genomic Hybridization / Q000379:methods*; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D015894:Genome, Human; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000378:metabolism / Q000473:pathology
chemical_list: D015704:CD4 Antigens; D004247:DNA