title: Oxidative stress and autoimmune skin disease.
abstract: Antioxidants play the important role in our body of neutralizing free radicals and peroxides that are formed during normal physiologic events. While these reactive oxygen species are necessary for numerous biological processes, when created in excess they can have deleterious effects. The skin as an organ is constantly under attack by reactive oxygen species from both endogenous and exogenous sources. The pathophysiology of many autoimmune diseases is unknown and recently oxidative stress has come to light as a possible triggering mechanism. Recent investigations attempting to link autoimmune skin diseases and oxidative stress have had varying degrees of success. In this article, we review the current literature regarding antioxidants in alopecia areata, pemphigus vulgaris and other blistering diseases, vitiligo, and psoriasis, and suggest possible future studies and treatment options.
authors: Department of Dermatology, University at Buffalo and Roswell Park Cancer Institute, Clinical and Translational Research Center, 875 Ellicott St. Buffalo, NY 14203, USA.
authors: Amit Aakash
authors: AA
authors: Shah
authors: Animesh A
authors: AA
authors: Sinha
mesh_terms: D000506:Alopecia Areata / Q000276:immunology / Q000378:metabolism; D001327:Autoimmune Diseases / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress; D010392:Pemphigus / Q000276:immunology / Q000378:metabolism; D011565:Psoriasis / Q000276:immunology / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012871:Skin Diseases / Q000276:immunology / Q000378:metabolism*; D014820:Vitiligo / Q000276:immunology / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species
keywords: alopecia areata; antioxidant; autoimmune; free radicals; oxidative stress; pemphigus vulgaris; reactive oxygen species; vitiligo