title: Quantitative structure-activity relationship analysis of thiazolidineones: potent antidiabetic compounds.
abstract: BACKGROUND
  Type 2 diabetes is the most common form of diabetes, accounting for over 90% of cases. Current treatment approaches for type 2 diabetes include diet, exercise, and a variety of pharmacologic agents, including insulin, biguanides, sulfonylureas, and thiazolidinediones.
  
  
  METHODS
  In the present scenario, researchers focused themselves on thiazolidine ring-based compounds to cure type 2 diabetes mellitus. Among the peroxisome proliferator activated receptor (PPAR) family, PPAR-γ is the most effective in curing glucose homeostasis.
  
  
  CONCLUSIONS
  Thiazolidine ring-based compounds act as PPAR-γ agonists, and herein, we have successfully developed nine derivatives of thiazolidine ring-based compounds that are found to be biologically potent using two-dimensional quantitative structure-activity relationship model.
authors: Department of Applied Chemistry, BBA University, Lucknow, Uttar Pradesh, India.
authors: Vijay Kumar
authors: VK
authors: Vishvakarma
authors: Prashant
authors: P
authors: Singh
authors: Monica
authors: M
authors: Dubey
authors: Kamlesh
authors: K
authors: Kumari
authors: Ramesh
authors: R
authors: Chandra
authors: Narender D
authors: ND
authors: Pandey
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology; D015195:Drug Design; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008954:Models, Biological; D047495:PPAR gamma / Q000819:agonists*; D021281:Quantitative Structure-Activity Relationship; D053778:Thiazolidines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007004:Hypoglycemic Agents; D047495:PPAR gamma; D053778:Thiazolidines