title: Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob/ob mice.
abstract: BACKGROUND
  Various mushrooms have been used in folk medicine for the treatment of lifestyle diseases in eastern countries, and several compounds that modulate the immune system, lower blood lipid levels, and inhibit tumor and viral action have been isolated. The fruiting body of Panellus serotinus (Mukitake) is recognized in Japan as one of the most delicious edible mushrooms, and previous studies have demonstrated that the dietary intake of powdered whole Mukitake or Mukitake extracts prevents the development of non-alcoholic fatty liver disease (NAFLD) in leptin-resistant db/db mice. In the present study, we evaluated the effect of the Mukitake diet on the pathogenesis of metabolic disorders in leptin-deficient ob/ob mice.
  
  
  RESULTS
  After 4 weeks of feeding, hepatomegaly, hepatic lipid accumulation, and elevated hepatic injury markers in the serum were markedly alleviated in Mukitake-fed ob/ob mice compared with control mice. Moreover, the mild hyperlipidemia in control ob/ob mice was attenuated and the elevated atherogenic index was reduced in Mukitake-fed ob/ob mice. These effects were partly attributable to the suppression of hepatic lipogenic enzyme activity due to the Mukitake diet.
  
  
  CONCLUSIONS
  The current results showed that Mukitake supplementation is beneficial for the alleviation of NAFLD and dyslipidemia in obese, diabetic ob/ob mice.
authors: Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan.
authors: Nao
authors: N
authors: Inoue
authors: Masashi
authors: M
authors: Inafuku
authors: Bungo
authors: B
authors: Shirouchi
authors: Koji
authors: K
authors: Nagao
authors: Teruyoshi
authors: T
authors: Yanagita
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism; D064429:Fatty Acid Synthases / Q000378:metabolism; D005526:Food, Formulated; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006529:Hepatomegaly / Q000188:drug therapy* / Q000378:metabolism; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000378:metabolism; D020738:Leptin / Q000172:deficiency / Q000235:genetics; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D010711:Phosphatidate Phosphatase / Q000378:metabolism; D011208:Powders / Q000737:chemistry / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D020738:Leptin; D011208:Powders; D014280:Triglycerides; D005954:Glucosephosphate Dehydrogenase; D002334:Carnitine O-Palmitoyltransferase; D064429:Fatty Acid Synthases; D010711:Phosphatidate Phosphatase