title: Three new nor-dammarane triterpenoids from Dysoxylum hainanense with particular cytotoxicity against glioma cell line.
abstract: Three new nor-dammarane triterpenoids, 12β-O-acetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (1), 12β,28-O-diacetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (2), 12β-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanran (3), together with one known compound, 12β-O-acetyl-15α,28-dihydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (4), were isolated from the 95 % EtOH extract of Dysoxylum hainanense. The structures of the new compounds were elucidated by spectral methods. All the triterpenoids were in vitro evaluated for their cytotoxic activities against four tumor cell lines (BGC-823, U251, HepG2 and SGC-7901). All the three nor-dammarane triterpenoids exhibited particular significant cytotoxic activities against glioma cell line.
authors: Department of Neurosurgery, Shenyang Northern Hospital, #83 Wenhua Road, Shenhe district, Shenyang, 110018, Liaoning Province, People's Republic of China. atocaopeng@hotmail.com
authors: Peng
authors: P
authors: Cao
authors: Guobiao
authors: G
authors: Liang
authors: Xu
authors: X
authors: Gao
authors: Xiaogang
authors: X
authors: Wang
authors: Zhiqing
authors: Z
authors: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D005910:Glioma / Q000188:drug therapy; D056945:Hep G2 Cells; D006801:Humans; D029582:Meliaceae; D024301:Plant Bark; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D000097669:Dammaranes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D014315:Triterpenes; D000097669:Dammaranes