title: Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity.
abstract: A new butenolide isoaspulvinone E (1), together with two known butenolides aspulvinone E (2) and pulvic acid (3) were isolated from the marine-derived fungus, Aspergillus terreus Gwq-48. They showed significant anti-influenza A H1N1 virus activities, with IC50 values of 32.3, 56.9, and 29.1μg/mL, respectively. Moreover, only compound 1 exhibited effective inhibitory activity against H1N1 viral neuraminidase (NA), and docking of two isomers (1-2) into the active sites of NA showed that the E double bond Δ(5(10)) was essential to achieve activity.
authors: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
authors: Huquan
authors: H
authors: Gao
authors: Wenqiang
authors: W
authors: Guo
authors: Qiang
authors: Q
authors: Wang
authors: Lianqing
authors: L
authors: Zhang
authors: Meilin
authors: M
authors: Zhu
authors: Tianjiao
authors: T
authors: Zhu
authors: Qianqun
authors: Q
authors: Gu
authors: Wei
authors: W
authors: Wang
authors: Dehai
authors: D
authors: Li
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000302:isolation & purification / Q000378:metabolism*; D001597:Benzylidene Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001665:Binding Sites; D020134:Catalytic Domain; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004285:Dogs; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D062105:Molecular Docking Simulation; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D058441:Rhizosphere; D012988:Soil Microbiology
chemical_list: D000998:Antiviral Agents; D001597:Benzylidene Compounds; C583197:isoaspulvinone E; C004511:butenolide; D009439:Neuraminidase; D015107:4-Butyrolactone