title: Distensibility of the esophagogastric junction assessed with the functional lumen imaging probe (FLIP™) in achalasia patients.
abstract: BACKGROUND
  The functional lumen imaging probe (FLIP), measures esophagogastric junction (EGJ) distensibility (cross-sectional area/luminal pressure) during volume-controlled distension. The aim of this study is to apply this tool to the assessment of the EGJ in untreated and treated achalasia patients and to compare EGJ distensibility with other diagnostic tools utilized in managing achalasia.
  
  
  METHODS
  Findings from FLIP, high-resolution manometry (HRM), timed barium esophagram, and symptom assessment by Eckardt Score (ES) were compared in 54 achalasia patients (23 untreated, 31 treated). Twenty healthy volunteers underwent FLIP as a comparator group. The EGJ distensibility index (EGJ-DI) was defined at the 'waist' of the FLIP bag during volumetric distension, expressed in mm(2)  mmHg(-1) . The ES was used to gauge treatment outcome: good response < 3 or poor response ≥ 3.
  
  
  RESULTS
  Of the 31 treated patients, 17 had good and 14 poor treatment response. The EGJ-DI was significantly different among groups, greatest in the control subjects and least in the untreated patients; patients with good treatment response had significantly greater EGJ-DI than untreated or patients with poor response. The correlations between EGJ-DI and ES and integrated relaxation pressure on HRM were significant.
  
  
  CONCLUSIONS
  The FLIP provided a useful measure of EGJ distensibility in achalasia patients that correlated with symptom severity. The measurement of EGJ distensibility was complementary to existing tests suggesting a potentially important role in the clinical management of achalasia.
authors: Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. j-pandolfino@northwestern.edu
authors: J E
authors: JE
authors: Pandolfino
authors: A
authors: A
authors: de Ruigh
authors: F
authors: F
authors: Nicodème
authors: Y
authors: Y
authors: Xiao
authors: L
authors: L
authors: Boris
authors: P J
authors: PJ
authors: Kahrilas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017097:Electric Impedance; D004724:Endoscopy; D004931:Esophageal Achalasia / Q000503:physiopathology*; D004943:Esophagogastric Junction / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged