title: Lipid-lowering effects of standardized extracts of Ilex paraguariensis in high-fat-diet rats.
abstract: Mate (Ilex paraguariensis A. St.-Hil) is a native species of South America used to prepare traditional beverages. Recently a possible effect of its infusion on oxidative stress found in dyslipidemias has been reported. The main compounds related to these activities are phenolic compounds derived from chlorogenic acid. This study aimed to determine the anticholesteremic effect of the hydroethanolic extract (HEIP) and its n-butanolic fraction (n-BFIP), with standardized content of phenolic compounds derived from chlorogenic acid, in rats treated with high-fat diet (HFD). The contents of these compounds in the ethanol extract and n-butanol fraction were respectively two and three times higher than in traditional infusion with predominance of dicaffeoylquinic derivatives. The extracts were able to reduce serum triglycerides and cholesterol and decrease the atherogenic index in treated animals. These results support a potential effect of the mate extract in cardiovascular disease.
authors: Instituto de Ciências Biológicas, Médicas e da Saúde, Universidade Paranaense, Toledo, PR, Brazil.
authors: Silvie
authors: S
authors: Balzan
authors: Aline
authors: A
authors: Hernandes
authors: Cristiane Loiva
authors: CL
authors: Reichert
authors: Carmen
authors: C
authors: Donaduzzi
authors: Vanessa Aranega
authors: VA
authors: Pires
authors: Arquimedes
authors: A
authors: Gasparotto
authors: Euclides Lara
authors: EL
authors: Cardozo
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control; D002726:Chlorogenic Acid / Q000031:analogs & derivatives / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D030019:Ilex paraguariensis / Q000737:chemistry*; D008055:Lipids / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D010636:Phenols; D010936:Plant Extracts; D014280:Triglycerides; D002726:Chlorogenic Acid; D002784:Cholesterol