title: Synthesis and physicochemical properties of new tripodal amphiphiles bearing fatty acids as a hydrophobic group.
abstract: Saturated fatty acids (FA) were grafted using tyrosine as a spacer group to the cyclotriphosphazene ring along with equimolar hydrophilic methoxy poly(ethylene glycol) (MPEG) in cis-nongeminal way. Seven new cyclotriphosphazene amphiphiles were prepared from combinations of hydrophilic MPEGs with different molecular weights of 350, 550, 750 and 1000 and four different fatty acids of different hydrophobicity including lauric, myristic, palmitic and stearic acids. These steric amphiphiles bearing fatty acids as a hydrophobic group were found to form more stable micelles with very low critical micelle concentrations (CMC) (2.95-7.80mg/L) compared with oligopeptide analogues, and their highly hydrophobic core environment is unique and potentially useful for various biomedical applications.
authors: Center for Cell Signaling & Drug Discovery Research, Division of Life and Pharmaceutical Sciences & College of Pharmacy, Ewha Womans University, 11-1 Daehyun-Dong, Seodaemun-Ku, Seoul 120-750, Republic of Korea.
authors: Prakash G
authors: PG
authors: Avaji
authors: Vithal B
authors: VB
authors: Jadhav
authors: Jin Xin
authors: JX
authors: Cui
authors: Yong Joo
authors: YJ
authors: Jun
authors: Hwa Jeong
authors: HJ
authors: Lee
authors: Youn Soo
authors: YS
authors: Sohn
mesh_terms: D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D008970:Molecular Weight; D009570:Nitriles / Q000737:chemistry; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D005227:Fatty Acids; D008823:Micelles; D009570:Nitriles; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol