title: The clinical outcomes of new hyaluronan nasal dressing: a prospective, randomized, controlled study.
abstract: BACKGROUND
  Poor postoperative wound healing after endoscopic sinus surgery (ESS) remains a significant problem. This study evaluates the efficacy and safety of a new absorbable hyaluronan hydrogel.
  
  
  METHODS
  A prospective, randomized, controlled trial  was conducted. Fifty-five patients with bilateral ESS were recruited and randomized to receive absorbable hyaluronan hydrogel in one side as treated and the opposite side without absorbable hyaluronan hydrogel as control. Clinical outcome measures were assessed at postoperative 1, 2, 4, 8,  and 12 weeks.
  
  
  RESULTS
  Fifty-four patients completed the study. Overall, absorbable hyaluronan hydrogel significantly promotes the reepithelization process and reduces the presence of obstructing synechia, nonobstructing synechia, edema, crust, and mild mucopurulent drainage  (all p ≤ 0.0002). At all postoperative follow-up visits, the promotion in reepithelization is statistically significant at 2, 4, and 8 weeks, and the reductions in the presence of nonobstructing synechia, edema, crust, and mild mucopurulent drainage are all statistically significant except  for the presence of crust at 12 weeks and mild mucopurulent drainage at 1 and 12 weeks. Although the presence of obstructing synechia at each follow-up visit between groups does not reach statistical significance, the incidence ranges from 5.56 to 12.96% in the control group and from 0 to  3.70% in the treated group. No adverse event related to treatment was observed.
  
  
  CONCLUSIONS
  In this clinical study, data analyses suggest that this new absorbable hyaluronan hydrogel, as nasal dressing/packing after ESS is safe and promotes the postoperative reepithelization  process and reduces the presence of synechia, edema, crust, and mild mucopurulent drainage.
authors: Department of Otolaryngology, Shanghai Ninth People's Hospital, Shanghai, China.
authors: Runjie
authors: R
authors: Shi
authors: Jiaqing
authors: J
authors: Zhou
authors: Bingshun
authors: B
authors: Wang
authors: Qingwei
authors: Q
authors: Wu
authors: Yuling
authors: Y
authors: Shen
authors: Peihua
authors: P
authors: Wang
authors: Jiadong
authors: J
authors: Wang
authors: Yunyun
authors: Y
authors: Wang
authors: Ying
authors: Y
authors: Chen
authors: Xiao Zheng
authors: XZ
authors: Shu
mesh_terms: D000328:Adult; D001458:Bandages; D002908:Chronic Disease; D004487:Edema / Q000209:etiology / Q000517:prevention & control*; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D012220:Rhinitis / Q000601:surgery*; D012852:Sinusitis / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects; D055815:Young Adult
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006820:Hyaluronic Acid