title: Absent or extremely low neutrophil alkaline phosphatase activity levels in patients with myelodysplastic syndromes.
abstract: Three patients with myelodysplastic syndrome (MDS) had absent or extremely low levels of neutrophil alkaline phosphatase (NAP) activity (arbitrarily defined as an NAP score <10). All patients showed varying degrees of hypogranulation in neutrophil morphology. The NAP activity levels transiently normalized following the administration of granulocyte colony-stimulating factor (G-CSF) in two cases. No patients experienced any severe infectious episodes. These results suggest that NAP activity is not central to the neutrophil function.
authors: Center for Hematological Diseases, Takeda General Hospital, Japan. yoshida@takedahp.or.jp
authors: Yataro
authors: Y
authors: Yoshida
authors: Tatsuya
authors: T
authors: Katsurada
authors: Shigeru
authors: S
authors: Oguma
authors: Yukiharu
authors: Y
authors: Nakabo
authors: Noriyoshi
authors: N
authors: Yoshinaga
authors: Masahiro
authors: M
authors: Kawahara
authors: Hiroshi
authors: H
authors: Kawabata
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000172:deficiency* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000201:enzymology*; D009504:Neutrophils / Q000201:enzymology*
chemical_list: D000469:Alkaline Phosphatase