title: Fetal cervical teratoma: What is the role of fetal MRI in predicting pulmonary hypoplasia?
abstract: OBJECTIVE
  To determine whether total fetal lung volumes estimated by MRI could predict lethal pulmonary hypoplasia in a cohort of fetuses with cervical teratomas.
  
  
  METHODS
  We performed a retrospective cohort study of fetal cervical teratomas from January 1, 2005, through April 1, 2012. The primary outcome was the ability of total lung volumes measured by MRI to predict neonatal mortality specifically due to pulmonary hypoplasia. Measured lung volumes were compared to previously reported normal values. The percent of observed-to-expected lung volume and the percent predicted lung volume were calculated. The positive and negative predictive values were calculated for each variable.
  
  
  RESULTS
  Fetal MRI-derived total lung volumes 1 standard deviation below the median for gestational age had a positive predictive value of 100% in predicting lethal pulmonary hypoplasia. Conversely, total lung volumes above this level were uniformly associated with pulmonary survival (100% negative predictive value). Additionally, percent predicted lung volume ≤75.7 and observed-to-expected lung volume ≤68.3 were associated with lethal pulmonary hypoplasia.
  
  
  CONCLUSIONS
  In this small cohort, MRI-estimated lung volumes were helpful in predicting the presence of pulmonary hypoplasia complicating fetal cervical teratoma.
authors: University of Cincinnati College of Medicine, Cincinnati, Ohio 80045, USA.
authors: Katherine
authors: K
authors: Wolfe
authors: David
authors: D
authors: Lewis
authors: David
authors: D
authors: Witte
authors: Beth
authors: B
authors: Kline-Fath
authors: Foong-Yen
authors: FY
authors: Lim
authors: Ronald
authors: R
authors: Jaekle
authors: Mounira
authors: M
authors: Habli
authors: Judith
authors: J
authors: Hostiuck
authors: Naira
authors: N
authors: Baregamian
authors: Sundeep
authors: S
authors: Keswani
authors: Timothy
authors: T
authors: Crombleholme
mesh_terms: D002574:Cervical Vertebrae; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006258:Head and Neck Neoplasms / Q000196:embryology / Q000473:pathology / Q000503:physiopathology*; D006776:Hospitals, Pediatric; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D008168:Lung / Q000002:abnormalities* / Q000196:embryology; D008279:Magnetic Resonance Imaging; D008297:Male; D009820:Ohio / Q000453:epidemiology; D009929:Organ Size; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D016019:Survival Analysis; D013724:Teratoma / Q000196:embryology / Q000473:pathology / Q000503:physiopathology*