title: Intentional rechallenge: does the benefit outweigh the risk?
abstract: Rechallenge is defined as the readministration of a medication suspected of being a possible cause of an adverse reaction and which has been discontinued as result. It may be unintentional when the appearance of a reaction was initially not attributed to the medication. A rechallenge may be intentional when a prescriber decides that the benefit of rechallenge will outweigh its risk. When considering intentional rechallenge, one should take into account the benefit/risk balance of the suspected causative medication, and the benefit/risk balance of the best available alternative treatment or no treatment. Clinical knowledge is essential in benefit/risk assessment but there is currently no suitable tool to guide the decision on rechallenge. This article aims to propose points to consider in the creation of reaction-specific algorithms for risk assessment and management in the case of drug rechallenge.
authors: School of PhD Studies, Semmelweis University, Budapest, Hungary. vid.stanulovic@gmail.com
authors: Vid
authors: V
authors: Stanulović
authors: Mauro
authors: M
authors: Venegoni
authors: Brian
authors: B
authors: Edwards
mesh_terms: D000465:Algorithms; D016903:Drug Monitoring / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D060735:Pharmacovigilance; D019233:Retreatment; D018570:Risk Assessment