title: Glyconanosomes: disk-shaped nanomaterials for the water solubilization and delivery of hydrophobic molecules.
abstract: Herein, we describe the first report on a new class of disk-shaped and quite monodisperse water-soluble nanomaterials that we named glyconanosomes (GNS). GNSs were obtained by sliding out the cylindrical structures formed upon self-organization and photopolymerization of glycolipid 1 on single-walled carbon nanotube (SWCNT) sidewalls. GNSs present a sheltered hydrophobic inner cavity formed by the carbonated tails, surrounded by PEG and lactose moieties. The amphiphilic character of GNSs allows the water solubility of insoluble hydrophobic cargos such as a perylene-bisimide derivative, [60]fullerene, or the anti-carcinogenic drug camptothecin (CPT). GNS/C60 inclusion complexes are able to establish specific interactions between peanut agglutinin (PNA) lectin and the lactose moiety surrounding the complexes, while CPT solubilized by GNS shows higher cytotoxicity toward MCF7-type breast cancer cells than CPT alone. Thus, GNS represents an attractive extension of nanoparticle-based drug delivery systems.
authors: Laboratory of Asymmetric Synthesis and Functional Nanosystems, Instituto de Investigaciones Químicas (IIQ), CSIC and Universidad de Sevilla, C/Américo Vepucio 49, 41092 Seville, Spain.
authors: Mohyeddin
authors: M
authors: Assali
authors: Juan-José
authors: JJ
authors: Cid
authors: Manuel
authors: M
authors: Pernía-Leal
authors: Miguel
authors: M
authors: Muñoz-Bravo
authors: Inmaculada
authors: I
authors: Fernández
authors: Ralf E
authors: RE
authors: Wellinger
authors: Noureddine
authors: N
authors: Khiar
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D002166:Camptothecin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D037741:Fullerenes / Q000008:administration & dosage; D006017:Glycolipids / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007094:Imides / Q000008:administration & dosage; D061986:MCF-7 Cells; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology; D037742:Nanotubes, Carbon / Q000737:chemistry / Q000648:ultrastructure; D019887:Peanut Agglutinin / Q000378:metabolism; D010569:Perylene / Q000008:administration & dosage / Q000031:analogs & derivatives; D012995:Solubility; D014867:Water
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D037741:Fullerenes; D006017:Glycolipids; D007094:Imides; D037742:Nanotubes, Carbon; D019887:Peanut Agglutinin; C510697:perylene bisimide; D014867:Water; D010569:Perylene; C069837:fullerene C60; D002166:Camptothecin