title: Iliac crest fresh-frozen allografts and autografts in maxillary and mandibular reconstruction: a histologic and histomorphometric evaluation.
abstract: OBJECTIVE
  The aim of this paper was to compare histologically and histomorphometrically the osseointegration of iliac crest fresh-frozen allografts and autografts in human pre-prosthetic maxillary and mandibular onlay bone blocks reconstruction.
  
  
  METHODS
  Twelve patients with edentulous atrophic ridges, scheduled for implant-supported prosthetic restorations, underwent reconstruction using iliac crest fresh-frozen allografts (group A, six patients) or autografts (group B, six patients). Four-to-nine months later implants were placed in the augmented areas and bone specimens were simultaneously obtained using trephine burs. The specimens were processed for ground sections and evaluated histologically and histomorphometrically.
  
  
  RESULTS
  The postoperative course was uneventful in all patients in group B and in all except one in group A. Late complications occurred in 5 patients of group A. Dental implants could be inserted in all cases. Specimens from group A showed a vascularized bone with osteoprogenitor stem cells and medium-high grade of bone remodeling. Small areas of necrotic bone were observed sporadically. Sections obtained from group B revealed an advanced stage of bone remodeling. The histomorphometric analysis showed in group A a mean proportion of 24.7±14.7% for lamellar bone, 28.4±13.3% for newly formed bone and 46.9±16.9% for bone marrow; in group B the corresponding values were 25.3±15.3%, 22.9±11.0%, 51.7±15.7%. No statistically significant difference was found (Wilcoxon Test; P>0.05).
  
  
  CONCLUSIONS
  There were no significant histological differences between group A and B. Larger studies with long term follow-up are needed to confirm that fresh-frozen allografts are a reliable alternative to autografts.
authors: Department of Health Sciences, University of Milan, Milan, Italy. daniela.carmagnola@unimi.it
authors: M
authors: M
authors: Chiapasco
authors: M
authors: M
authors: Giammattei
authors: D
authors: D
authors: Carmagnola
authors: L
authors: L
authors: Autelitano
authors: D
authors: D
authors: Rabbiosi
authors: C
authors: C
authors: Dellavia
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D016723:Bone Remodeling; D015925:Cryopreservation; D003758:Dental Implantation, Endosseous; D005260:Female; D006801:Humans; D007085:Ilium / Q000637:transplantation*; D007575:Jaw, Edentulous / Q000601:surgery; D008297:Male; D008334:Mandible / Q000098:blood supply / Q000473:pathology* / Q000601:surgery; D063175:Mandibular Reconstruction / Q000379:methods*; D008437:Maxilla / Q000098:blood supply / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D016348:Osseointegration; D010011:Osteocytes / Q000648:ultrastructure; D020858:Tissue and Organ Harvesting; D014182:Transplantation, Autologous; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous; D055815:Young Adult