title: Evaluation of the process of recycling and renal parenchymal injury after eswl with metabolites excreted in the urine.
abstract: OBJECTIVE
  To show renal parenchymal injury depending on extracorporeal shock wave lithotripsy (ESWL).
  
  
  METHODS
  The patients with one renal stone and in whom ESWL is planned among the patients in whom renal stone was determined. Their 24-h urine samples were collected just before and after the ESWL treatment. Cit (citrate), UrA (uric acid), RBP (retinol-binding protein), NAG (N-acetyl-β-Đ-glucosaminidase), Cr (creatinine), Na (sodium), K (potassium), P (phosphor), Ca (calcium), and Cl (chlorine) metabolites excreted in urine were evaluated after urine samples were taken on the study day. Changes in the metabolites excreted; the number, frequency, and duration of ESWL shock wave; the energy; and the body mass index were recorded. The results for p < 0.05 will be accepted as statistically significant.
  
  
  RESULTS
  Two sessions of ESWL were applied to a total of 20 patients. When metabolites excreted in the urine before (B1E) and after (A1E) the first session of ESWL, and before (B2E) and after (A2E) the second session of ESWL, were evaluated, no statistically significant result for Ca and Cl excretion was noted. For NAG and Cr, a significant difference was observed in terms of metabolite excretion between B1E and B2E. For other metabolites, we saw that there is no difference between B1E and B2E. While a significant metabolite change was observed for RBP, NAG, Cr, and Na as long as A1E and A2E ESWL session number increases, other metabolites were not significant.
  
  
  CONCLUSIONS
  Shock waves induce significant damage to the renal and adjacent tissues as indicated by a significant increase in cell-escaped enzymes and electrolytes and the extent of damage depends on the energy and the number of shock wave exposure.
authors: Department of Urology Clinic of Turkiye, Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors: Cavit
authors: C
authors: Ceylan
authors: Serkan
authors: S
authors: Dogan
authors: Gulsevim
authors: G
authors: Saydam
authors: Mehmet Zait
authors: MZ
authors: Kocak
authors: Omer Gokhan
authors: OG
authors: Doluoglu
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000368:Aged; D002118:Calcium / Q000652:urine; D002712:Chlorides / Q000652:urine; D002951:Citrates / Q000652:urine; D003404:Creatinine / Q000652:urine; D006801:Humans; D007668:Kidney / Q000293:injuries*; D007669:Kidney Calculi / Q000378:metabolism / Q000628:therapy* / Q000652:urine*; D008096:Lithotripsy / Q000009:adverse effects*; D008875:Middle Aged; D010865:Pilot Projects; D011188:Potassium / Q000652:urine; D012177:Retinol-Binding Proteins / Q000652:urine*; D012964:Sodium / Q000652:urine; D016896:Treatment Outcome; D014527:Uric Acid / Q000652:urine
chemical_list: D002712:Chlorides; D002951:Citrates; D012177:Retinol-Binding Proteins; D014527:Uric Acid; D012964:Sodium; D003404:Creatinine; D000118:Acetylglucosaminidase; D011188:Potassium; D002118:Calcium