title: Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) new complexes of 5-aminosalicylic acid: spectroscopic, thermal characterization and biological activity studies.
abstract: The complexing behavior of mesalazine (5-aminosalicylic acid; 5-ASA) towards the transition metal ions namely, Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) have been examined by elemental analyses, magnetic measurements, electronic, IR and (1)H NMR. Thermal properties and decomposition kinetics of all complexes are investigated. The interpretation, mathematical analyses and evaluation of kinetic parameters of all thermal decomposition stages have been evaluated using Coats-Redfern equation. The free ligand and its metal complexes have been tested in vitro against Aspergillus fumigatus and Candida albicans fungi and Pseudomonas aeruginosa, Escherichia coli, Bacillis subtilies and Staphylococcus aureus bacteria in order to assess their antimicrobial potential. The results indicate that the metal complexes are also found to have more antimicrobial activity than the parent 5-ASA drug.
authors: Chemistry Department, Faculty of Science, Helwan University, P.O. Box 11795, Helwan, Egypt. drmadihahasn@yahoo.com
authors: Madiha H
authors: MH
authors: Soliman
authors: Gehad G
authors: GG
authors: Mohamed
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019804:Mesalamine / Q000737:chemistry* / Q000494:pharmacology; D009181:Mycoses / Q000188:drug therapy; D017550:Spectroscopy, Fourier Transform Infrared; D013816:Thermodynamics; D028561:Transition Elements / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D056831:Coordination Complexes; D028561:Transition Elements; D019804:Mesalamine