title: Emerging insights into the ependymoma epigenome.
abstract: Ependymoma is the third most common pediatric brain tumor, yet because of the paucity of effective therapeutic interventions, 45% of patients remain incurable. Recent transcriptional and copy number profiling of the disease has identified few driver genes and in fact points to a balanced genomic profile. Candidate gene approaches looking at hypermethylated promoters and genome-wide epigenetic arrays suggest that DNA methylation may be critical to ependymoma pathogenesis. This review attempts to highlight existing and emerging evidence implicating the ependymoma epigenome as a key player and that epigenetic modifiers may offer new targeted therapeutic avenues for patients.
authors: Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. stephen.mack@mail.utoronto.ca
authors: Stephen C
authors: SC
authors: Mack
authors: Hendrik
authors: H
authors: Witt
authors: Xin
authors: X
authors: Wang
authors: Till
authors: T
authors: Milde
authors: Yuan
authors: Y
authors: Yao
authors: Kelsey C
authors: KC
authors: Bertrand
authors: Andrey
authors: A
authors: Korshunov
authors: Stefan M
authors: SM
authors: Pfister
authors: Michael D
authors: MD
authors: Taylor
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002648:Child; D019175:DNA Methylation; D004806:Ependymoma / Q000235:genetics* / Q000473:pathology; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans