title: Death at the airway epithelium in asthma.
abstract: Allergic asthma is an inflammatory disease of the airways in which epithelial cells, dendritic cells and innate lymphoid cells are increasingly implicated. Recent findings suggest that apoptotic cells are phagocytosed by airway epithelial cells in a Rac1-dependent manner and this leads to dampening of innate and adaptive immunity to allergens.
authors: Department for Molecular Biomedical Research, VIB, Gent, Belgium. bart.lambrecht@ugent.be
authors: Bart N
authors: BN
authors: Lambrecht
authors: Hamida
authors: H
authors: Hammad
mesh_terms: D000485:Allergens / Q000276:immunology; D017209:Apoptosis; D001249:Asthma / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D000067596:Interleukin-33; D007378:Interleukins / Q000037:antagonists & inhibitors / Q000378:metabolism; D010586:Phagocytes / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000378:metabolism; D020830:rac1 GTP-Binding Protein / Q000378:metabolism
chemical_list: D000485:Allergens; C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins; D016212:Transforming Growth Factor beta; D016753:Interleukin-10; D020830:rac1 GTP-Binding Protein