title: The effect of androgens on lipids.
abstract: OBJECTIVE
  To review recent data concerning the relationship between endogenous testosterone and lipids as well as testosterone replacement therapy and lipids. To describe the effects of sex hormones on cardiovascular disease (CVD) that may act via serum lipids.
  
  
  RESULTS
  Low endogenous testosterone is associated with high low-density lipoprotein and low high-density lipoprotein in both cross-sectional and prospective observational studies. Exogenous testosterone administration is associated with decreased high-density lipoprotein coupled with beneficial decreases in low-density lipoprotein and total cholesterol. The overall impact of testosterone administration on CVD is still unclear, with mixed safety results from recent randomized controlled trials.
  
  
  CONCLUSIONS
  There may be CVD risk reduction benefits, including an improved lipid profile, from testosterone administration in hypogonadal men. The overall effect of testosterone on CVD risk has not been definitively determined.
authors: Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Maryland, USA.
authors: Anne K
authors: AK
authors: Monroe
authors: Adrian S
authors: AS
authors: Dobs
mesh_terms: D000728:Androgens / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013739:Testosterone / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D000728:Androgens; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D013739:Testosterone; D005640:Follicle Stimulating Hormone