title: Distinct expression patterns of syndecans in the embryonic zebrafish brain.
abstract: Axon pathfinding in the neuroepithelium of embryonic brain is dependent on a variety of short and long range guidance cues. Heparan sulfate proteoglycans such as syndecans act as modulators of these cues and their importance in neural development is highlighted by their phylogenetic conservation. In Drosophilia, a single syndecan is present on the surface of axon growth cones and is required for chemorepulsive signalling during midline crossing. Understanding the role of syndecans in the vertebrate nervous system is challenging given that there are four homologous genes, syndecans 1-4. We show here that syndecans 2-4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.
authors: Brain Growth and Regeneration Lab, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Queensland, Australia.
authors: Wolfgang
authors: W
authors: Hofmeister
authors: Christine A
authors: CA
authors: Devine
authors: Brian
authors: B
authors: Key
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D047108:Embryonic Development / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D055495:Neurogenesis / Q000235:genetics; D010802:Phylogeny; D015398:Signal Transduction / Q000235:genetics; D053669:Syndecan-2 / Q000235:genetics*; D053670:Syndecan-3 / Q000235:genetics*; D053671:Syndecan-4 / Q000235:genetics*; D015027:Zebrafish / Q000235:genetics* / Q000254:growth & development; D029961:Zebrafish Proteins / Q000235:genetics*
chemical_list: D053670:Syndecan-3; D053671:Syndecan-4; D029961:Zebrafish Proteins; C508249:sdc2 protein, zebrafish; D053669:Syndecan-2