title: Strategies to direct angiogenesis within scaffolds for bone tissue engineering.
abstract: There is a profound need for orthopaedic grafting strategies due to various trauma and musculoskeletal diseases. Tissue engineering offers a promising avenue to develop viable grafts for bone repair. The transfer of bone tissue engineering strategies to clinical applications is limited by the failure to adequately vascularize scaffolds after implantation. This review focuses on the natural processes for bone and vessel formation as well as the microenvironmental cues and microscale fabrication techniques to properly coordinate these events towards successful vascularization of tissue engineered scaffolds.
authors: Department of Chemical Engineering, University of South Carolina, Columbia, SC 29208, USA. ehsan@sc.edu.
authors: Greg M
authors: GM
authors: Harris
authors: Katy
authors: K
authors: Rutledge
authors: Qingsu
authors: Q
authors: Cheng
authors: James
authors: J
authors: Blanchette
authors: Ehsan
authors: E
authors: Jabbarzadeh
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry; D001842:Bone and Bones / Q000098:blood supply; D050723:Fractures, Bone / Q000628:therapy; D006801:Humans; D009140:Musculoskeletal Diseases / Q000628:therapy; D018919:Neovascularization, Physiologic; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D018786:Bone Substitutes