title: Localized Castleman's disease in the breast.
abstract: BACKGROUND
  Castleman's disease (CD) is a rare disease with unknown etiology and is clinically associated with lymph nodes enlargement. Primary axillary localization of CD represents 2% of the cases. CD rarely occurs in the breasts.
  
  
  METHODS
  We herein describe a rare case of CD that initially presented in the breast intramammary lymph node and demonstrated axillary adenopathy. Pathologic analysis showed the hyaline vascular form. The patient underwent axillary lymphadenectomy. The natural history was irregular because the localized CD progressed to a systemic form of CD. At 4.6years of follow-up a Hodgkin's lymphoma appeared.
  
  
  CONCLUSIONS
  This is the fourth published case of localized breast CD published. It is important to evaluate other clinical lymphadenopathies at the time of diagnosis, and computed tomography is important for disease evaluation and follow-up.
  
  
  CONCLUSIONS
  Patients must undergo axillary lymphadenectomy when showing clinical symptoms. Irregular progression prompts new lymph node biopsy because of the potential presence of associated diseases.
authors: Barretos Cancer Hospital, Pio XII Foundation, São Paulo State, Brazil. Electronic address: posgrad@hcancerbarretos.com.br.
authors: René Aloísio da Costa
authors: RA
authors: Vieira
authors: Jorge Shigueo
authors: JS
authors: Kunizaki
authors: Abaeté Leite
authors: AL
authors: do Canto
authors: Adriano Diniz Baptista
authors: AD
authors: Mendes
authors: José Spartaco
authors: JS
authors: Vial
authors: Angelo Gustavo Zucca
authors: AG
authors: Matthes
authors: Anapaula Uema
authors: AU
authors: Watanabe
authors: Cristovam
authors: C
authors: Scapulatempo Neto