title: Exercise attenuates renal dysfunction with preservation of myocardial function in chronic kidney disease.
abstract: Previous studies have suggested that exercise improves renal and cardiac functions in patients with chronic kidney disease. The aim of this study was to evaluate the effects of long-term aerobic swimming exercise with overload on renal and cardiac function in rats with 5/6 nefrectomy (5/6Nx). Eight Wistar rats were placed into 4 groups: Control (C), Control+Exercise (E), Sedentary 5/6Nx (NxS) and 5/6Nx+Exercise (NxE). The rats were subjected to swimming exercise sessions with overload for 30 min five days per week for five weeks. Exercise reduced the effect of 5/6Nx on creatinine clearance compared to the NxS group. In addition, exercise minimized the increase in mean proteinuria compared to the NxS group (96.9±10.0 vs. 51.4±9.9 mg/24 h; p<0.05). Blood pressure was higher in the NxS and NxE groups compared to the C and E groups (216±4 and 178±3 vs. 123±2 and 124±2 mm Hg, p<0.05). In the 200 glomeruli that were evaluated, the NxS group had a higher sclerosis index than did the NxE group (16% vs. 2%, p<0.05). Echocardiography demonstrated a higher anterior wall of the left ventricle (LV) in diastole in the NxS group compared with the C, E and NxE groups. The NxS group also had a higher LV posterior wall in diastole and systole compared with the E group. The developed isometric tension in Lmax of the heart papillary muscle was lower in the NxS group compared with the C, E and NxE groups. These results suggested that exercise in 5/6Nx animals might reduce the progression of renal disease and lessen the cardiovascular impact of a reduction in renal mass.
authors: Nephrology Division, Department of Medicine, Federal University of São Paulo (UNIFESP/EPM), São Paulo, Brazil. rafakarate@hotmail.com
authors: Rafael da Silva
authors: Rda S
authors: Luiz
authors: Kleiton Augusto Santos
authors: KA
authors: Silva
authors: Rodolfo Rosseto
authors: RR
authors: Rampaso
authors: Ednei Luiz
authors: EL
authors: Antônio
authors: Jairo
authors: J
authors: Montemor
authors: Danilo Sales
authors: DS
authors: Bocalini
authors: Leonardo
authors: L
authors: Dos Santos
authors: Luiz
authors: L
authors: Moura
authors: Paulo José Ferreira
authors: PJ
authors: Tucci
authors: Nayda Parísio
authors: NP
authors: de Abreu
authors: Nestor
authors: N
authors: Schor
mesh_terms: D000818:Animals; D004452:Echocardiography; D006321:Heart / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar