title: A novel label-free cascade amplification strategy based on dumbbell probe-mediated rolling circle amplification-responsive G-quadruplex formation for highly sensitive and selective detection of NAD+ or ATP.
abstract: A novel label-free fluorescent sensing scheme for sensitive and selective detection of NAD(+) and ATP has been developed based on dumbbell probe-mediated rolling circle amplification (D-RCA)-responsive G-quadruplex formation. This approach can detect 0.5 pM for ATP and 100 fM for NAD(+), much lower than those of previously reported biosensors, and exhibits high discrimination ability.
authors: Key Laboratory for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, PR China.
authors: Qingwang
authors: Q
authors: Xue
authors: Lei
authors: L
authors: Wang
authors: Wei
authors: W
authors: Jiang
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000378:metabolism*; D054856:G-Quadruplexes; D009243:NAD / Q000737:chemistry / Q000378:metabolism*; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D058105:Polymerization
chemical_list: D009243:NAD; D000251:Adenosine Triphosphatases