title: Influence of a moderate physical activity intervention on red cell deformability in patients suffering from chronic obstructive pulmonary disease (COPD).
abstract: The present study investigates whether a moderate physical activity intervention may alter red cell deformability (RCD) of patients suffering from chronic obstructive pulmonary disease (COPD). Subjects (n = 10; age: 62 ± 4; body-mass index (BMI): 25.8 ± 7.5) performed a training regimen for 10 weeks. In the beginning of the study and after the training period, COPD patients underwent a WHO cycle ergometry test. Venous blood samples were taken before (T0), immediately after (T1) and 30 min after (T2) the intervention. RCD was measured with the laser-assisted optical rotational cell analyzer (LORCA). Significant improvements of the RCD were detected. The semi-maximal shear stress increased significantly. Acute exhaustion had no effect on RCD. Thus, the training period of 10 weeks influenced RCD.
authors: Department of Molecular and Cellular Sport Medicine, Institute for Cardiovascular Research and Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany. Brixius@dshs-koeln.de
authors: Basit
authors: B
authors: Ahmad
authors: Nina
authors: N
authors: Ferrari
authors: Georgina
authors: G
authors: Montiel
authors: Wilhelm
authors: W
authors: Bloch
authors: Anke
authors: A
authors: Raabe-Oetker
authors: Nina
authors: N
authors: Skrobala
authors: Klara
authors: K
authors: Brixius
mesh_terms: D000368:Aged; D004907:Erythrocyte Deformability / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000145:classification / Q000534:rehabilitation*; D055070:Resistance Training; D033081:Shear Strength