title: A Study on the Efficacy of Proton Pump Inhibitors in Helicobacter pylori-Negative Primary Care Patients with Dyspepsia in Japan.
abstract: OBJECTIVE
  There have been few studies on the efficacy of proton pump inhibitors and the doses required to treat dyspeptic symptoms observed in clinical practice. The aim of this study was to compare the efficacy of different doses of omeprazole and different administration methods in Helicobacter pylori-negative, dyspeptic patients.
  
  
  METHODS
  Patients with chronic upper abdominal symptoms within the previous 3 months were randomly divided into three groups: a daily, omeprazole 20 mg treatment group (OPZ20, n=61); a daily, omeprazole 10 mg treatment group (OPZ10, n=72); and an on-demand omeprazole 20 mg treatment group (on-demand, n=62). After 4 weeks of administration of the drug, symptom improvement rates were evaluated based on the Overall Global Severity score.
  
  
  RESULTS
  The rates of symptom improvement after 4 weeks of treatment were 65.6% (40/61) in the OPZ20 group, 47.2% (34/72) in the OPZ10 group, and 50.0% (31/62) in the on-demand group. The OPZ20 group exhibited a significantly higher improvement rate (p=0.034) than the OPZ10 group. The OPZ20 group had significant improvements in regurgitation, postprandial fullness, vomiting, and bloating compared with the OPZ10 group.
  
  
  CONCLUSIONS
  Daily treatment with 20 mg of omeprazole was efficient in treating upper abdominal symptoms.
  
  
  BACKGROUND
  ClinicalTrials.gov, number UMIN000002621.
authors: Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.
authors: Tomoari
authors: T
authors: Kamada
authors: Yoshinori
authors: Y
authors: Fujimura
authors: Kensuke
authors: K
authors: Gotoh
authors: Hiroshi
authors: H
authors: Imamura
authors: Noriaki
authors: N
authors: Manabe
authors: Hiroaki
authors: H
authors: Kusunoki
authors: Kazuhiko
authors: K
authors: Inoue
authors: Akiko
authors: A
authors: Shiotani
authors: Jiro
authors: J
authors: Hata
authors: Ken
authors: K
authors: Haruma
keywords: Dyspepsia; Omeprazole; Primary health care; Proton pump inhibitors