title: Cardiovascular disease prevention: matching evidence-based algorithms with individualized care.
abstract: The appropriate use of statins in primary prevention remains a matter of debate. Although statins reduce cardiovascular events at all levels of baseline risk, they are associated with rare but important side effects including incident diabetes. Herein, we review strategies for statin allocation ranging from strict "evidence-based" adherence to randomized controlled clinical trial (RCT) entry criteria to more "personalized" risk assessment using high-sensitivity C-reactive protein (hsCRP), coronary artery calcification (CAC), or genetic testing. Current guidelines advocate an unusual middle ground between an evidence-based approach and a personalized approach.
authors: Department of Medicine, Morristown Medical Center-Atlantic Health System, Morristown, New Jersey, USA.
authors: R
authors: R
authors: Madanieh
authors: R K
authors: RK
authors: Hasan
authors: O F
authors: OF
authors: Anusionwu
authors: R S
authors: RS
authors: Blumenthal
authors: M J
authors: MJ
authors: Blaha
mesh_terms: D000465:Algorithms; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D019317:Evidence-Based Medicine / Q000379:methods* / Q000706:statistics & numerical data; D017408:Guidelines as Topic; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D057285:Precision Medicine / Q000379:methods*; D011322:Primary Prevention / Q000379:methods
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors