title: The role of progesterone in implantation and trophoblast invasion.
abstract: With its genomic and non-genomic actions, progesterone plays a role in preparing the endometrium for implantation and also in regulating trophoblast invasion and migration. The genomic actions of progesterone are mediated by the classical nuclear progesterone receptors, PR-A and PR-B. In addition to their genomic actions, nuclear progesterone receptors may also trigger rapid cytoplasmic signalling events. Membrane-bound progesterone receptors have been implicated in the rapid non-genomic actions of progesterone. Both genomic and extra-nuclear actions of progesterone are crucial for adequate decidualisation and implantation. Progesterone plays a role in establishing uterine receptivity by blocking the proliferative effect of oestrogen, by inducing genes that allow the endometrium to permit embryo attachment, and also acts as a negative regulator of trophoblast invasion by controlling matrix metalloproteinase (MMP) activity.
authors: Department of Medical Microbiology and Immunology, Medical School, University of Pecs, Pecs, Hungary. melinda.halasz@kk.pte.hu
authors: Melinda
authors: M
authors: Halasz
authors: Julia
authors: J
authors: Szekeres-Bartho
mesh_terms: D000818:Animals; D048708:Cell Growth Processes; D002465:Cell Movement; D010064:Embryo Implantation; D004717:Endometrium / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000502:physiology*; D011980:Receptors, Progesterone / Q000378:metabolism*; D015398:Signal Transduction; D014327:Trophoblasts / Q000502:physiology*
chemical_list: D004967:Estrogens; D011980:Receptors, Progesterone; D011374:Progesterone; D020782:Matrix Metalloproteinases