title: A clinical feasibility study to evaluate the safety and efficacy of PEOT/PBT implants for human donor site filling during mosaicplasty.
abstract: Mosaicplasty has become a well-accepted treatment modality for articular cartilage lesions in the knee. Postoperative bleeding remains potentially concerning. This study evaluates the porous poly(ethylene oxide)terephthalate/poly(butylene terephthalate) (PEOT/PBT) implants used for donor site filling. Empty donor sites were the controls. After 9 months, MRI, macroscopical and histological analysis were carried out. Treated defects did not cause postoperative bleeding. No adverse events or inflammatory response was observed. PEOT/PBT implants were well integrated. Empty controls occasionally showed protrusion of repair tissue at the defect margins. Surface stiffness was minimally improved compared to controls. Existing polymer fragments indicated considerable biodegradation. Histological evaluation of the filled donor sites revealed congruent fibrocartilaginous surface repair with proteoglycan-rich domains and subchondral cancellous bone formation with interspersed fibrous tissue in all implanted sites. The PEOT/PBT implants successfully reduce donor site morbidity and postoperative bleeding after mosaicplasty.
  
  
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authors: Orthopaedic and Trauma Department, Uzsoki Hospital, Uzsoki Str. 29, 1145, Budapest, Hungary.
authors: Lajos
authors: L
authors: Bartha
authors: Doreen
authors: D
authors: Hamann
authors: Jeroen
authors: J
authors: Pieper
authors: Fabiènne
authors: F
authors: Péters
authors: Jens
authors: J
authors: Riesle
authors: Andras
authors: A
authors: Vajda
authors: Pal Kaposi
authors: PK
authors: Novak
authors: Laszlo Rudolf
authors: LR
authors: Hangody
authors: Gabor
authors: G
authors: Vasarhelyi
authors: Laszlo
authors: L
authors: Bodó
authors: Clemens
authors: C
authors: van Blitterswijk
authors: Joost
authors: J
authors: de Wijn
authors: Annamaria
authors: A
authors: Kenyeres
authors: Laszlo
authors: L
authors: Modis
authors: Eszter
authors: E
authors: Balo
authors: Laszlo
authors: L
authors: Hangody
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D001178:Arthroplasty / Q000009:adverse effects / Q000379:methods; D001672:Biocompatible Materials / Q000009:adverse effects / Q000627:therapeutic use*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020007:Implants, Experimental; D007719:Knee Joint / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D011091:Polyesters / Q000009:adverse effects / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000627:therapeutic use*; D011093:Polyethylene Terephthalates; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D011859:Radiography; D054457:Tissue Scaffolds; D014182:Transplantation, Autologous / Q000009:adverse effects / Q000379:methods; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011093:Polyethylene Terephthalates; C041733:poly(1,4-butylene terephthalate); D011092:Polyethylene Glycols