title: Role of the nuclear receptor Tailless in adult neural stem cells.
abstract: Tailless (Tlx) is an orphan nuclear receptor which is specifically expressed in the neural stem cells of the two largest germinal neurogenesis zones in the adult mouse brain, the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus. By interacting with its cofactors, Tlx represses its target genes and plays an important role in the maintenance of adult NSCs. This review provides a snapshot of current knowledge about Tlx function in adult NSCs.
authors: Helmholtz Professorship of Molecular Biology of the Cell I, German Cancer Research Center-DKFZ, The DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.
authors: Yu
authors: Y
authors: Wang
authors: Hai-Kun
authors: HK
authors: Liu
authors: Günther
authors: G
authors: Schütz
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D018891:Dentate Gyrus / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D020547:Lateral Ventricles / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D055495:Neurogenesis; D011485:Protein Binding; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D009419:Nerve Tissue Proteins; C490258:Nr2e1 protein, mouse; D018160:Receptors, Cytoplasmic and Nuclear