title: Combinatorial synthesis of pyrazoloquinoline and pyrazoloacridine derivatives with high regioselectivity.
abstract: Three-component reaction of aldehyde, 1H-indazol-6-amine and 1,3-dicarbonyl compounds in EtOH under catalyst-free conditions, generates the corresponding pyrazolo[3,4-a]acridine, cyclopenta[b]pyrazolo[3,4-f]quinoline, indeno[1,2-b]pyrazolo[3,4-f]quinoline and benzo[h]pyrazolo[3,4-a]acridine derivatives in high yields and regioselectivity, respectively. The dicarbonyl compounds include 5,5-dimethylcyclohexane-1,3-dione, cyclopentane-1,3-dione, 2H-indene- 1,3-dione and 2-hydroxynaphthalene-1,4-dione.
authors: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou Jiangsu 221116, PR China.
authors: Dong-Sheng
authors: DS
authors: Chen
authors: Yu-Jing
authors: YJ
authors: Zhou
authors: Yu-Ling
authors: YL
authors: Li
authors: Chang-Sheng
authors: CS
authors: Yao
authors: Xiang-Shan
authors: XS
authors: Wang
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D011720:Pyrazoles / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000166:Acridines; D011720:Pyrazoles; D011804:Quinolines