title: Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer.
abstract: The synthesis of a novel pharmacophore comprising a DNA-targeted platinum-acridine hybrid agent and estrogen receptor-targeted 4-hydroxy-N-desmethyltamoxifen (endoxifen) using carbamate coupling chemistry and its evaluation in breast cancer cell lines are described.
authors: Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109, USA.
authors: Song
authors: S
authors: Ding
authors: Xin
authors: X
authors: Qiao
authors: Gregory L
authors: GL
authors: Kucera
authors: Ulrich
authors: U
authors: Bierbach
mesh_terms: D000166:Acridines / Q000737:chemistry*; D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D005260:Female; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D061986:MCF-7 Cells; D010984:Platinum / Q000737:chemistry*; D011960:Receptors, Estrogen / Q000037:antagonists & inhibitors / Q000378:metabolism; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000166:Acridines; D018931:Antineoplastic Agents, Hormonal; D007364:Intercalating Agents; D011960:Receptors, Estrogen; D013629:Tamoxifen; C055492:4-hydroxy-N-desmethyltamoxifen; D010984:Platinum; D004247:DNA