title: Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
abstract: The Fms-like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase, is involved in the proliferation, differentiation and apoptosis of hematopoietic cells. FLT3 is highly overexpressed in acute myeloid leukemia (AML) of the majority of patients. Screening for flavonoids including flavones, flavanones, flavonols, and flavanonols disclosed that luteolin was potent FLT3 enzyme inhibitor. Furthermore, luteolin suppressed cell proliferation in MV4;11 cells with constitutively activated FLT3.
authors: College of Pharmacy, Dongguk University-Seoul, Goyang, Gyeonggi-do 410-820, South Korea.
authors: Young-Won
authors: YW
authors: Chin
authors: Jae Yang
authors: JY
authors: Kong
authors: Sun-Young
authors: SY
authors: Han
mesh_terms: D059447:Cell Cycle Checkpoints / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D047311:Luteolin / Q000737:chemistry / Q000633:toxicity; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000633:toxicity; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D005419:Flavonoids; D047428:Protein Kinase Inhibitors; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3; D047311:Luteolin