title: Prenatal nutritional influence on skeletal development.
abstract: There is increasing evidence to suggest that prenatal nutritional factors may have long-term effects on the offspring. Osteoporosis is a worldwide public health problem leading to both morbidity and mortality, through associated bone fractures. Although in clinical practice most effort in fracture prevention is aimed at slowing the rate of age-related bone loss, there is accumulating evidence that peak bone mass, achieved in early adulthood, is an important factor in determining bone strength in later life. A variety of studies have shown that peak bone mass is influenced by early life events, including nutrition in the prenatal period. This chapter will use the example of bone development to consider the effects of maternal diet and nutritional status on the offspring.
authors: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
authors: Elizabeth
authors: E
authors: Curtis
authors: Jonathan
authors: J
authors: Cheah
authors: Nicholas C
authors: NC
authors: Harvey
mesh_terms: D015519:Bone Density; D001846:Bone Development; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D050723:Fractures, Bone; D006801:Humans; D008019:Life Style; D039382:Maternal Nutritional Physiological Phenomena; D010024:Osteoporosis / Q000517:prevention & control; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood
chemical_list: D014807:Vitamin D