title: Curcumin, a potential therapeutic candidate for retinal diseases.
abstract: Curcumin, the major extraction of turmeric, has been widely used in many countries for centuries both as a spice and as a medicine. In the last decade, researchers have found the beneficial effects of curcumin on multiple disorders are due to its antioxidative, anti-inflammatory, and antiproliferative properties, as well as its novel function as an inhibitor of histone aectyltransferases. In this review, we summarize the recent progress made on studying the beneficial effects of curcumin on multiple retinal diseases, including diabetic retinopathy, glaucoma, and age-related macular degeneration. Recent clinical trials on the effectiveness of phosphatidylcholine formulated curcumin in treating eye diseases have also shown promising results, making curcumin a potent therapeutic drug candidate for inflammatory and degenerative retinal and eye diseases.
authors: College of Life Sciences, Wuhan University, Wuhan, PR China.
authors: Lei-Lei
authors: LL
authors: Wang
authors: Yue
authors: Y
authors: Sun
authors: Kun
authors: K
authors: Huang
authors: Ling
authors: L
authors: Zheng
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000494:pharmacology*; D003930:Diabetic Retinopathy / Q000188:drug therapy; D004195:Disease Models, Animal; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008268:Macular Degeneration / Q000188:drug therapy; D012164:Retinal Diseases / Q000188:drug therapy*; D012174:Retinitis Pigmentosa / Q000188:drug therapy; D012175:Retinoblastoma / Q000188:drug therapy; D018630:Vitreoretinopathy, Proliferative / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D003474:Curcumin
keywords: Anti-inflammation; Antioxidative; Curcumin; Epigenetics; Retinal diseases