title: Crohn's disease and polymorphism of heat shock protein gene HSP70-2 in the Chinese population.
abstract: OBJECTIVE
  Crohn's disease (CD) is a multifactorial disorder with a pivotal role of the genetic component. A single nucleotide polymorphism in heat shock protein 70-2 (HSP70-2) has been shown to be associated with a severe clinical course in CD. The purpose of this study was to identify associations between the HSP70-2 polymorphism and the clinical courses of CD in the Chinese population.
  
  
  METHODS
  One hundred patients with CD and 190 healthy individuals were genotyped for the HSP70-2 PstI polymorphism by restriction fragment length polymorphism analysis.
  
  
  RESULTS
  The genotype frequency of the PstI polymorphism did not differ between patients and controls. The A allele was higher in CD patients than in controls (61% vs 52%, P = 0.047, odds ratio [OR] = 1.423, 95% confidence interval [CI]: 1.004-2.015). Furthermore, this polymorphism was higher in the penetrating or fistula surgery of CD patients than in controls (63% vs 52%, P = 0.049, OR = 1.530, 95% CI: 1.001-2.337; Table ). But there was no significant difference between the penetrating or fistula surgery patients and no surgery patients (P = 0.673, OR = 0.883, 95% CI: 0.495-1.574). We used multivariate analysis to determine the effects of genotypes on sex, disease behavior, disease location, and so on. No significant difference was observed between these parameters and genotype.
  
  
  CONCLUSIONS
  This study reported that the allele A of PstI polymorphism was the association between CD and HSP70-2 gene in the Chinese population. It was also association between penetrating or fistula surgery of CD and HSP70-2 gene in the Chinese population.
authors: The Research Institute of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China.
authors: Jun
authors: J
authors: Chen
authors: Jianan
authors: J
authors: Ren
authors: Guosheng
authors: G
authors: Gu
authors: Gefei
authors: G
authors: Wang
authors: Xiuwen
authors: X
authors: Wu
authors: Dongsheng
authors: D
authors: Yan
authors: Song
authors: S
authors: Liu
authors: Jieshou
authors: J
authors: Li
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D018840:HSP70 Heat-Shock Proteins; C525621:HSPA1B protein, human