title: Cytologic features of low-grade cribriform cystadenocarcinoma of the submandibular gland: a case report.
abstract: BACKGROUND
  Low-grade cribriform cystadenocarcinomas (LGCCC) are rare salivary gland tumors, classified into a variant of cystadenocarcinoma by the 2005 WHO classification. All previously reported cases arose from parotid glands, except for a case from a minor salivary gland. We report here for the first time a case of LGCCC arising from the submandibular gland.
  
  
  METHODS
  A 65-year-old man presented with a 4-cm multicystic mass in the left submandibular gland. Smears from fine-needle aspiration cytology showed tumor cells, appearing solitarily or partly in clusters, with thick cytoplasm and central nuclei. Some clustering tumor cells showed large cytoplasmic vacuoles and peripherally dislocated nuclei. Although these findings indicated a possible mucoepidermoid carcinoma in the submandibular gland, the final diagnosis of the resected specimen was LGCCC.
  
  
  CONCLUSIONS
  LGCCC can arise not only from the parotid glands, but also in the submandibular glands. LGCCC is thought to be of low-grade malignancy; no reported cases have shown tumor metastasis and there are no patients who are known to have died of this disease. Thus, differential diagnosis of this tumor from other malignant salivary gland tumors is quite important; however, this might be difficult when based solely on cytological findings.
authors: Department of Diagnostic Pathology, Social Insurance, Gunma Chuo General Hospital, Maebashi, Japan.
authors: Akane
authors: A
authors: Obokata
authors: Shinji
authors: S
authors: Sakurai
authors: Junko
authors: J
authors: Hirato
authors: Kazuha
authors: K
authors: Sakamoto
authors: Tetsuo
authors: T
authors: Takekoshi
authors: Jun
authors: J
authors: Aoki
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D003536:Cystadenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009077:Mucins / Q000032:analysis; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D013365:Submandibular Gland Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D009077:Mucins