title: Genetic variants of AICDA/CASP14 associated with childhood brain tumor.
abstract: We conducted a hospital-based case-control study in Korea to investigate whether apoptosis- and cell cycle control-related genes are associated with childhood brain tumor. Incident brain tumor cases (N = 70) and non-cancer controls (N = 140), frequency-matched by age and gender, were selected from 3 teaching hospitals in Seoul between 2003 and 2006. Tag single nucleotide polymorphisms (SNPs) (N = 297) in 30 genes related to apoptosis and cell cycle control were selected using a pairwise linkage-disequilibrium-based algorithm. Five tag SNPs in 2 genes (AICDA and CASP14) remained significant after adjusted multiple tests. The most significant association with childhood brain tumor risk was for IVS1-401G>C in the AICDA gene [odds ratio (OR) = 2.8; 95% confidence interval (95%CI) = 1.25-6.46]; the polymorphism *9276A>C of CASP14 was associated with decreased brain tumor risk (OR = 0.4; 95%CI = 0.19-0.95). We concluded that genetic polymorphisms in AICDA and CASP14 are associated with risk for brain tumor in Korean children.
authors: Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
authors: S
authors: S
authors: Jeon
authors: S
authors: S
authors: Han
authors: K
authors: K
authors: Lee
authors: J
authors: J
authors: Choi
authors: S K
authors: SK
authors: Park
authors: A K
authors: AK
authors: Park
authors: H S
authors: HS
authors: Ahn
authors: H Y
authors: HY
authors: Shin
authors: H J
authors: HJ
authors: Kang
authors: H H
authors: HH
authors: Koo
authors: J J
authors: JJ
authors: Seo
authors: J E
authors: JE
authors: Choi
authors: H
authors: H
authors: Kim
authors: Y
authors: Y
authors: Ahn
authors: D
authors: D
authors: Kang
mesh_terms: D017209:Apoptosis / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics*; D020169:Caspases / Q000235:genetics*; D002453:Cell Cycle / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003564:Cytidine Deaminase / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D056910:Republic of Korea; D012307:Risk Factors; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
chemical_list: C506446:CASP14 protein, human; D020169:Caspases; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase