title: Management of a rifampicin-resistant meningococcal infection in a teenager.
abstract: We report a secondary case of rifampicin-resistant meningococcal disease and our experience in managing contact cases. Rifampicin resistance resulting from rpoB gene mutations is still uncommon enough that changing the current recommendations for chemoprophylaxis is unwarranted. However, ensuring limited but appropriate chemoprophylaxis may prevent the development of antimicrobial resistance. Thus, the definition of contact cases should be strictly respected. In the case of culture-positive Neisseria meningitidis, in vitro susceptibility testing to rifampicin must be systematically performed in order to detect rifampicin-resistant strains and, thus, institute appropriate prophylaxis in order to prevent secondary transmission.
authors: Service de Biologie Médicale, Hôpital d'Instruction des Armées Bégin, 69 avenue de Paris, 94163, Saint Mandé Cedex, France. delaunedeborah@hotmail.com
authors: D
authors: D
authors: Delaune
authors: D
authors: D
authors: Andriamanantena
authors: A
authors: A
authors: Mérens
authors: E
authors: E
authors: Viant
authors: O
authors: O
authors: Aoun
authors: F
authors: F
authors: Ceppa
authors: M-K
authors: MK
authors: Taha
authors: C
authors: C
authors: Rapp
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008585:Meningitis, Meningococcal / Q000188:drug therapy* / Q000382:microbiology* / Q000517:prevention & control / Q000635:transmission; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000187:drug effects* / Q000302:isolation & purification; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D012293:Rifampin