title: Lanostane-type triterpenoid and steroid from the stem bark of Klainedoxa gabonensis.
abstract: A new lanostane triterpenoid, 2-hydroxy-24-methylenelanostan-1,8-dien-3-one named klainedoxalanostenone (1) with one new steroid, 6-O-acyl-β-d-glucosyl-β-sitosterol named klainedoxasterol (2) together with ten known compounds including six triterpenoids (3-8), two steroids (9, 10) and two tanins (11, 12) were isolated from the stem bark of Klainedoxa gabonensis. To the best of our knowledge, this is the first report of lanostane-type triterpenoids from this genus. Their structures were determined by extensive analysis of spectroscopic data (1D and 2D NMR, MS) and by comparison with literature data. The xanthine oxidase inhibitory activity of nine compounds (1-6, 8, 10 and 11) were evaluated. Compound 5 showed a good xanthine oxidase inhibitory activity; the other tested compounds were moderately active.
authors: Chemistry Department, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
authors: Eric René Sieliatchom
authors: ER
authors: Nkanwen
authors: Anar Sahib
authors: AS
authors: Gojayev
authors: Hippolyte Kamdem
authors: HK
authors: Wabo
authors: Jean Jules Kezetas
authors: JJ
authors: Bankeu
authors: Muhammad Choudhary
authors: MC
authors: Iqbal
authors: Akif Alakbar
authors: AA
authors: Guliyev
authors: Pierre
authors: P
authors: Tane
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018547:Plant Stems; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: C584359:2-hydroxy-24-methylenelanostan-1,8-dien-3-one; C584362:6-O-acyl-beta-D-glucosyl-beta-sitosterol; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014315:Triterpenes; D007810:Lanosterol; D014969:Xanthine Oxidase