title: STX6 rs1411478 is not associated with increased risk of Parkinson's disease.
abstract: A variant in Syntaxin 6 (a soluble N-ethylmaleimide-sensitive factor attachment protein receptor STX6) (rs1411478) has been shown to be associated with progressive supranuclear palsy (PSP). Although Parkinson's disease (PD) and PSP are distinct neurodegenerative diseases, they share some clinical and genetic features. In this study, we evaluated STX6 genetic variability in PD susceptibility in ethnically matched case-control series from Canada, Norway, Taiwan and Tunisia and we evaluated the presence of pathogenic mutations within families. No pathogenic mutations were found in STX6. Similarly, statistical analysis of rs1411478 failed to identify differences in genotype or allelic frequencies between cases and controls. Our results do not support a role for STX6 in PD.
authors: Department of Medical Genetics, Centre for Applied Neurogenetics, University of British Columbia, Vancouver, BC, Canada V6T 2B5.
authors: Joanne
authors: J
authors: Trinh
authors: Carles
authors: C
authors: Vilariño-Güell
authors: Alan
authors: A
authors: Donald
authors: Brinda
authors: B
authors: Shah
authors: Irene
authors: I
authors: Yu
authors: Chelsea
authors: C
authors: Szu-Tu
authors: Jan O
authors: JO
authors: Aasly
authors: Ruey-Meei
authors: RM
authors: Wu
authors: Faycal
authors: F
authors: Hentati
authors: Ali H
authors: AH
authors: Rajput
authors: Alex
authors: A
authors: Rajput
authors: Matthew J
authors: MJ
authors: Farrer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada / Q000208:ethnology; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000208:ethnology; D010300:Parkinson Disease / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics*; D050765:Qa-SNARE Proteins / Q000235:genetics*; D012307:Risk Factors; D013624:Taiwan / Q000208:ethnology; D014416:Tunisia / Q000208:ethnology
chemical_list: D050765:Qa-SNARE Proteins