title: The effectiveness of using different pulp-capping agents on the healing response of the pulp.
abstract: BACKGROUND
  Some of the disadvantages of calcium hydroxide Ca(OH) 2 as pulp-capping material are related to the inflammatory response, and its poor sealing ability. Cyanoacrylate glue was proposed in this study as pulp-capping agent because of its sealing ability, and diprogenta, on the other hand, was proposed because of its anti-microbial and anti-inflammatory effects. The aim of this study is to evaluate and compare the histopathological response of the pulp toward cyanoacrylate and diprogenta in direct pulp capping (DPC).
  
  
  METHODS
  Cyanoacrylate, diprogenta, and calcium hydroxide were applied on 20 permanent teeth of 6 rabbits divided into four groups, each contains five teeth, as follow: G1: Diprogenta and calcium hydroxide. G2: Cyanoacrylate. G3: Diprogenta and cyanoacrylate. G4: Calcium hydroxide (control group).
  
  
  RESULTS
  A remarkable dentin bridge formation was found in all groups. No pulp necrosis was found in any tooth of the four groups. Pathological reactions of the pulp were found in 25%, 40%, 20%, and 100% of groups 1, 2, 3, and 4, respectively. Differences between study and control groups were found statistically significant ( P < 0.05).
  
  
  CONCLUSIONS
  All materials used in this study were biocompatible and suggested to be studied further on human teeth. These materials when used in combination with Ca(OH) 2 , may give better results.
authors: Department of Biomedical Dental Sciences, University of Dammam, Dammam 31551, Saudi Arabia.
authors: B
authors: B
authors: Aljandan
authors: H
authors: H
authors: AlHassan
authors: A
authors: A
authors: Saghah
authors: M
authors: M
authors: Rasheed
authors: A A
authors: AA
authors: Ali
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001623:Betamethasone / Q000031:analogs & derivatives / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000627:therapeutic use; D002126:Calcium Hydroxide / Q000627:therapeutic use; D002133:Calcium Sulfate; D003487:Cyanoacrylates / Q000627:therapeutic use; D003782:Dental Pulp / Q000098:blood supply / Q000187:drug effects*; D003785:Dental Pulp Capping / Q000379:methods; D003789:Dental Pulp Exposure / Q000628:therapy; D003794:Dental Restoration, Temporary; D003809:Dentin, Secondary / Q000187:drug effects; D004338:Drug Combinations; D005839:Gentamicins / Q000627:therapeutic use; D006940:Hyperemia / Q000209:etiology; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use*; D011671:Pulpitis / Q000209:etiology; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects; D019287:Zinc Sulfate
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; C504942:Coltosol F; D003487:Cyanoacrylates; D004338:Drug Combinations; D005839:Gentamicins; D057872:Pulp Capping and Pulpectomy Agents; C119247:octylcyanoacrylate; C007530:betamethasone-17,21-dipropionate, gentamicin drug combination; D019287:Zinc Sulfate; D001623:Betamethasone; D002126:Calcium Hydroxide; D002133:Calcium Sulfate