title: [EGFR mutation status in Uighur lung adenocarcinoma patients].
abstract: OBJECTIVE
  Epidermal growth factor receptor (EGFR), a transmembrane protein, is a member of the tyrosine kinase family. Gefitinib, an EGFR tyrosine-kinase inhibitors, has shown a high response rate in the treatment of lung cancer in patients with EGFR mutation. However, significant differences in EGFR mutations exist among different ethnic groups. The aim of this study is to investigate the prevalence of EGFR mutations in Uighur lung adenocarcinoma patients by using a rapid and sensitive detection method and to analyze EGFR mutation differences compared with Han lung adenocarcinoma patients.
  
  
  METHODS
  We examined lung adenocarcinoma tissues from 138 patients, including 68 Uighur lung adenocarcinoma patients and 70 Han lung adenocarcinoma patients, for EGFR mutations in exons 18, 19, 20, and 21 by using the amplification refractory mutation system (ARMS) PCR method. The mutation differences between Uighur and Han lung adenocarcinoma were compared by using the chi-square test method.
  
  
  RESULTS
  EGFR mutations were detected in 43 (31.2%) of the 138 lung adenocarcinoma patients. EGFR mutations were detected in 11 (16.2%) of the 68 Uighur lung adenocarcinoma patients and in 32 (45.7%) of the 70 Han lung adenocarcinoma patients. Significant differences were observed in the EGFR mutations between Uighur lung adenocarcinoma patients and Han lung adenocarcinoma patients (P<0.001).
  
  
  CONCLUSIONS
  Our results indicate that the EGFR mutation in Uighur lung adenocarcinoma patients (16.2%) is significantly lower than that in Han lung adenocarcinoma patients (45.7%).
authors: Affiliated Cancer Hospital, Xinjiang Medical University, Urumuqi 830000, China.
authors: Li
authors: L
authors: Shan
authors: Yan
authors: Y
authors: Zhang
authors: Feng
authors: F
authors: Zhao
authors: Limou
authors: L
authors: Zheng
authors: Guoqing
authors: G
authors: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000208:ethnology* / Q000235:genetics*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D002681:China / Q000208:ethnology; D066246:ErbB Receptors / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D059645:Mutation Rate
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors