title: Glioblastomas with oligodendroglial component have the same clinical phenotype as classical glioblastomas.
abstract: BACKGROUND
  Glioblastomas are the commonest primary brain tumour and are considered one of the most heterogeneous tumour types. The introduction of a glioblastoma with oligodendroglial component (GBM + O) in the latest WHO Classification of Tumours of the Central Nervous System (1) was to help with this. There has been conflicting evidence as to whether this tumour conferred a better prognosis than classical glioblastoma (GBM). The aim of this study was to study the clinical phenotype of these GBM + O tumours and compare it to the classical GBM.
  
  
  METHODS
  All patients with histological evidence of a glioblastoma between 1st January 2007 and 31st January 2011 were identified from the Neuropathology Database. Clinical and radiological details were obtained for all patients. The overall survival of patients who were treated with chemoradiotherapy was obtained and the GBM + O cohort compared to the classical GBM cohort.
  
  
  RESULTS
  Three hundred and ninety-six patients with newly diagnosed glioblastomas were identified: 294 (74.2%) had classical GBM and 102 (25.6%) had GBM + O. The two cohorts presented at a similar age (61.1 years GBM + O vs. 63.2 years GBM; P = 0.09) and were matched for sex and side of the tumour. GBM + O were more likely to be located in the frontal lobes (38.2% for GBM + O vs. 27.2% for GBM: P = 0.04). In the group that was treated with chemoradiotherapy the overall survival was similar (median survival GBM + O 361 days vs. 379 days GBM; Log Rank 0.61, P = 0.43).
  
  
  CONCLUSIONS
  The presence of an oligodendroglial component does not confer any improvement in survival and has a similar clinical phenotype to classical GBMs.
authors: Department of Neurosurgery, Addenbrooke's Hospital, Cambridge University Hospitals Foundation Trust , Cambridge , UK.
authors: Ashraf
authors: A
authors: Elmahdi
authors: Amy J
authors: AJ
authors: Frary
authors: William J
authors: WJ
authors: Scotton
authors: Dominic G
authors: DG
authors: O'Donovan
authors: Stephen J
authors: SJ
authors: Price
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D059248:Chemoradiotherapy; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D005909:Glioblastoma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009837:Oligodendroglioma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D010641:Phenotype; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult