title: Gender differences in 1-year clinical characteristics and outcomes after stroke: results from the China National Stroke Registry.
abstract: BACKGROUND
  Previous reports have shown inconsistent results on clinical outcomes between women and men after stroke, and little is known about gender differences on outcomes in Chinese post-stroke patients. The aim of this study was to explore whether there were gender differences on clinical characteristics and outcomes in Chinese patients after ischemic stroke by using the data from the China National Stroke Registry (CNSR).
  
  
  RESULTS
  Out of 12,415 consecutively recruited patients with acute ischemic stroke in the CNSR from 2007 to 2008, 11,560 (93.1%) patients were followed up for 12 months. Their clinical characteristics and outcomes on death, recurrence, and dependency were recorded. The multivariate logistic regression was performed to determine whether there were gender differences in these outcomes. Women were older than men at baseline (67.9 vs. 64.0 years, P<0.001). Women had a higher mortality, recurrence rate, and dependency rate at 3, 6, and 12 months than men, but after adjusting for age, history of diabetes, pre-stroke dependency, stroke severity, in-hospital complications, and other confounders, there were no statistically significant differences in gender on mortality and recurrence rate at 3, 6, and 12 months; and dependency rate at 3, and 6 months. However, the dependency rate at 12 months remained significantly higher in women (odds ratio, 1.24; 95% confidence interval, 1.06 to 1.45).
  
  
  CONCLUSIONS
  There are many differences in clinical characteristics between women and men after ischemic stroke in China. Compared with men, women are more dependent at 12 months after stroke. This difference still exists after controlling the potential confounders.
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: Zhan
authors: Z
authors: Wang
authors: Jingjing
authors: J
authors: Li
authors: Chunxue
authors: C
authors: Wang
authors: Xiaomei
authors: X
authors: Yao
authors: Xingquan
authors: X
authors: Zhao
authors: Yilong
authors: Y
authors: Wang
authors: Hao
authors: H
authors: Li
authors: Gaifen
authors: G
authors: Liu
authors: Anxin
authors: A
authors: Wang
authors: Yongjun
authors: Y
authors: Wang
mesh_terms: D000367:Age Factors; D000368:Aged; D044466:Asian People; D002681:China; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data*; D011446:Prospective Studies; D012008:Recurrence; D012042:Registries / Q000706:statistics & numerical data*; D012737:Sex Factors; D020521:Stroke / Q000175:diagnosis* / Q000208:ethnology / Q000401:mortality; D015996:Survival Rate; D013997:Time Factors