title: Which types of regulatory T cells play important roles in implantation and pregnancy maintenance?
abstract: Regulatory T cells (Treg) play essential roles in implantation and allogeneic pregnancy maintenance in mice and humans. Recent data have shown the heterogeneity of Treg, such as thymic (naturally occurring) Treg, extrathymic (inducible or peripheral) Treg, naïve Treg, effector Treg, resting (non-proliferating) Treg and activated (proliferating) Treg. Importantly, Foxp3, which was believed to be a specific marker for Treg, is transiently expressed in T cells when conventional T cells are activated and proliferating in humans showing that Foxp3 is not a specific marker for Treg. Therefore, we should evaluate the true Treg level and clarify which types of Treg cells play important roles in implantation and pregnancy maintenance in mice and humans.
authors: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan. s30saito@med.u-toyama.ac.jp
authors: Shigeru
authors: S
authors: Saito
authors: Tomoko
authors: T
authors: Shima
authors: Kumiko
authors: K
authors: Inada
authors: Akitoshi
authors: A
authors: Nakashima
mesh_terms: D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism; D010064:Embryo Implantation / Q000276:immunology*; D005260:Female; D051858:Forkhead Transcription Factors / Q000096:biosynthesis; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors