title: Simultaneous determination of cytosine arabinoside and its metabolite, uracil arabinoside, in human plasma using hydrophilic interaction liquid chromatography with UV detection.
abstract: A practical high-performance liquid chromatography using a Cosmosil HILIC column and UV detection was developed for determining the concentrations of cytosine arabinoside (Ara-C) and uracil arabinoside (Ara-U), which is a major metabolite of Ara-C, in human plasma. This method was used to determine the plasma concentrations of Ara-C and Ara-U in a patient treated with high-dose Ara-C therapy for end-stage renal failure.
authors: Department of Pharmacy, Fukuoka University Hospital, Fukuoka, Japan.
authors: Masanobu
authors: M
authors: Uchiyama
authors: Yasushi
authors: Y
authors: Takamatsu
authors: Kentaro
authors: K
authors: Ogata
authors: Taichi
authors: T
authors: Matsumoto
authors: Shiro
authors: S
authors: Jimi
authors: Kazuo
authors: K
authors: Tamura
authors: Shuuji
authors: S
authors: Hara
mesh_terms: D001086:Arabinofuranosyluracil / Q000097:blood* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003561:Cytarabine / Q000097:blood* / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D057230:Limit of Detection; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003561:Cytarabine; D001086:Arabinofuranosyluracil