title: The characteristics of ulcerative colitis associated with autoimmune pancreatitis.
abstract: OBJECTIVE
  To determine the prevalence of ulcerative colitis (UC) in autoimmune pancreatitis (AIP) patients in a tertiary referral hospital and to compare the clinical and pathologic characteristics and outcomes of UC associated with AIP (AIP-UC) and UC patients.
  
  
  BACKGROUND
  Recently, it was suggested that UC is associated with AIP. However, the prevalence of UC in AIP, together with the clinical characteristics and outcomes of AIP-UC are not clear.
  
  
  METHODS
  We retrospectively reviewed the medical records of AIP patients diagnosed at the Asan Medical Center.
  
  
  RESULTS
  Of the 104 patients with AIP, 6 (5.8%) were also diagnosed with UC. Serum immunoglobulin G (IgG) and IgG4 were elevated in 1 patient (16.7%), respectively, and 4 (66.7%) showed idiopathic duct-centric pancreatitis (type 2 AIP). Compared with 24 matched patients with UC only, AIP-UC patients had a lower body mass index (P=0.003), higher C-reactive protein levels (P=0.048), and higher Mayo scores (P=0.006) at diagnosis of UC. Two AIP-UC patients (33.3%), but none with UC only showed increased infiltration of IgG4-positive cells into the colonic tissues (P=0.006). During follow-up, 2 AIP-UC patients (33.3%) underwent colectomy and 1 (16.7%) died, but no colectomies or deaths occurred in the UC only group.
  
  
  CONCLUSIONS
  AIP patients seem to have a higher risk of UC compared with the general population. The increased IgG4-positive cellular infiltration in the colonic tissue suggests that UC may be an extrapancreatic manifestation of AIP.
authors: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Sang Hyoung
authors: SH
authors: Park
authors: Donghoi
authors: D
authors: Kim
authors: Byong Duk
authors: BD
authors: Ye
authors: Suk-Kyun
authors: SK
authors: Yang
authors: Ji-Hun
authors: JH
authors: Kim
authors: Dong-Hoon
authors: DH
authors: Yang
authors: Kee Wook
authors: KW
authors: Jung
authors: Kyung-Jo
authors: KJ
authors: Kim
authors: Jeong-Sik
authors: JS
authors: Byeon
authors: Seung-Jae
authors: SJ
authors: Myung
authors: Myung-Hwan
authors: MH
authors: Kim
authors: Jin-Ho
authors: JH
authors: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000150:complications* / Q000473:pathology; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult