title: Inflammatory factors gene polymorphism in recurrent oral ulceration.
abstract: BACKGROUND
  Some inflammatory factors play an important role in recurrent oral ulceration (ROU). The genetics mechanism of expression level of inflammatory factors is not clear in ROU, but from genetics the expression level of inflammatory factors at least partly depend on the gene polymorphisms. Therfore, we decided to investigate inflammatory factors gene polymorphism and its association with the susceptibility of recurrent oral ulceration in Chinese.
  
  
  METHODS
  Genomic DNA was obtained from 42 subjects with recurrent oral ulceration, 86 subjects of healthy control individuals.Genotypes and alleles of 10 genes and 17 polymorphisms sites were analyzed by Mass-ARRAY Analyzer method. Then, the differences in distribution of each genotype and allele were compared.
  
  
  RESULTS
  The statistical differences in distribution of TNF-α (rs1800629 and rs1800630) genotype and allele were observed among the groups with recurrent oral ulceration and healthy control individuals (P < 0.01), while VEGFA (rs1570360, rs833061, and rs2010963), EGF (rs4444903), TNF (rs361525), IL10 (rs1800896, rs1800872), IL2 (rs2069762), IL4 (rs2243250), Fas (rs1800682, rs2234767), IL12A (rs2243115, rs568408), IL12B (rs3212227), and IFNG (rs2430561) showed no statistical differences of genotype and allele in controls as compared to those in patients.
  
  
  CONCLUSIONS
  This study suggests that the TNF-α (rs1800629 and rs1800630) genotype is an indicator for the susceptibility of recurrent oral ulceration.
authors: Center for DNA Typing, Fourth Military Medical University, Xi'an, China.
authors: Mao
authors: M
authors: Sun
authors: Shan-Min
authors: SM
authors: Fu
authors: Guang-Ying
authors: GY
authors: Dong
authors: Dan
authors: D
authors: Wu
authors: Guo-Xia
authors: GX
authors: Wang
authors: Yuanming
authors: Y
authors: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002648:Child; D004815:Epidermal Growth Factor / Q000032:analysis; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human / Q000235:genetics; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis; D016753:Interleukin-10 / Q000032:analysis; D053765:Interleukin-12 Subunit p35 / Q000032:analysis; D053762:Interleukin-12 Subunit p40 / Q000032:analysis; D007376:Interleukin-2 / Q000032:analysis; D015847:Interleukin-4 / Q000032:analysis; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D013281:Stomatitis, Aphthous / Q000235:genetics* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis; D055815:Young Adult; D019014:fas Receptor / Q000032:analysis
chemical_list: C491901:FAS protein, human; C573415:IFNG protein, human; C508609:IL10 protein, human; C508858:IL12A protein, human; C500879:IL12B protein, human; C508594:IL2 protein, human; C508598:IL4 protein, human; D053765:Interleukin-12 Subunit p35; D053762:Interleukin-12 Subunit p40; D007376:Interleukin-2; D007378:Interleukins; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D019014:fas Receptor; D016753:Interleukin-10; D015847:Interleukin-4; D004815:Epidermal Growth Factor; D007371:Interferon-gamma
keywords: gene polymorphisms; inflammatory factors; recurrent oral ulceration; susceptibility