title: Halting the spread of epidemic pseudomonas aeruginosa in an adult cystic fibrosis centre: a prospective cohort study.
abstract: OBJECTIVE
  To assess if cohort segregation policies are effective in preventing cross-infection in cystic fibrosis (CF) clinics.
  
  
  METHODS
  A prospective cohort study.
  
  
  METHODS
  A large adult CF centre in Northwest England.
  
  
  METHODS
  All CF patients cared for at the Liverpool adult CF centre 2003-2009.
  
  
  METHODS
  Regular sputum sampling with genotyping of pseudomonas aeruginosa (Psa) isolates led to a policy of inpatient and outpatient segregation by microbiological group.
  
  
  METHODS
  Prevalence and cross-infection/super-infection rates of a transmissible Psa strain, i.e. the Liverpool epidemic strain (LES) in adult CF patients at the Liverpool adult CF centre from 2003 to 2009.
  
  
  RESULTS
  There was a decline in the proportion of patients with LES (71-53%) and an increase in those with unique strains (23-31%) and without Psa infection (6-17%) from 2003 to 2009. There were two cases of LES super-infection and one case of new chronic Psa infection (with a unique strain). There were no cases of transmissible strain infection in patients previously uninfected by Psa.
  
  
  CONCLUSIONS
  Our segregation policy has halted the spread of the commonest highly transmissible strain in the UK (LES) in our clinic, without endangering patients who were not previously infected with Psa. It confirms that if genotypic surveillance is used, it is unnecessary to segregate patients infected with unique strains from those without Psa infection.
authors: Liverpool Heart and Chest Hospital ,  Liverpool L14 3PE ,  UK.
authors: Abdul
authors: A
authors: Ashish
authors: Matthew
authors: M
authors: Shaw
authors: Craig
authors: C
authors: Winstanley
authors: Linda
authors: L
authors: Humphreys
authors: Martin J
authors: MJ
authors: Walshaw