title: Mitochondrial haplogroup B4 may be a protective factor to oral lichen planus susceptibility in Chinese.
abstract: OBJECTIVE
  Oral lichen planus (OLP) is a common inflammatory disorder with a higher prevalence among women than men. The pathogenesis of OLP is still unclear, and its heredity is not well characterized. Maternal inheritance of mitochondrial DNA (mtDNA) indicates its importance in human ethnic group classification as well disease susceptibility. So, this study was conducted to find whether mtDNA haplogroup associates with OLP susceptibility in Chinese, and determine the influence of C-stretch structure of mtDNA on OLP susceptibility.
  
  
  METHODS
  We sequenced three hypervariable regions of mtDNA from 242 patients with OLP and 237 healthy controls. The association between mtDNA haplogroups and OLP is tested by chi-square test.
  
  
  RESULTS
  Seventeen kinds of haplogroups were identified, and the frequency of haplogroup B4 was significantly higher in control group than that of the OLP group (P = 0.013, OR=0.429). In female samples, B4 declared even more significance (P = 0.003, OR=0.296). Meanwhile, the haplotypes of C-stretch in mtDNA did not have any significant difference between case-control groups.
  
  
  CONCLUSIONS
  Mitochondrial DNA haplogroup B4 might have a protective effect to OLP, and its protective effect resides predominantly in women. However, the association between C-stretch haplotype and OLP susceptibility still needs more patients for evaluation.
authors: Center for DNA Typing, Forth Military Medical University, Xi'an, China; Department of Biochemistry and Molecular Biology, Forth Military Medical University, Xi'an, China.
authors: D
authors: D
authors: Wu
authors: S
authors: S
authors: Cheng
authors: X
authors: X
authors: Chen
authors: M
authors: M
authors: Sun
authors: G
authors: G
authors: Wang
authors: S
authors: S
authors: Fu
authors: G
authors: G
authors: Dong
authors: L
authors: L
authors: Wang
authors: Y
authors: Y
authors: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000145:classification*; D004198:Disease Susceptibility; D005260:Female; D006239:Haplotypes; D006801:Humans; D017676:Lichen Planus, Oral / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D065840:Protective Factors; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial
keywords: C-stretch; genetics; haplogroup; mitochondrial DNA; oral lichen planus