title: Peritransplant gastrointestinal symptoms in familial amyloidotic polyneuropathy.
abstract: OBJECTIVE
  Gastrointestinal dysfunction is a common complication in familial amyloidotic polyneuropathy, and gastrointestinal symptoms are associated with a patient's nutritional status. The object of this study was to evaluate changes in peritransplant gastrointestinal symptoms and the nutritional status of familial amyloidotic polyneuropathy patients using the modified body mass index following a living-donor liver transplant.
  
  
  METHODS
  In a retrospective analysis, we compared 17 Japanese familial amyloidotic polyneuropathy patients who underwent living-donor liver transplant in Kumamoto University Hospital between 2000 and 2009 with a control group of 28 patients with chronic liver disease. We analyzed the peritransplant gastrointestinal symptoms, nutritional status, duration of central venous catheterization, and postoperative hospital stay. The Mann-Whitney U test and Fisher exact test were used to analyze relations between the familial amyloidotic polyneuropathy group and control group, and the Wilcoxon signed-rank test, to analyze the relation of perioperative modified body mass index, with a value for P < .05 considered statistically significant.
  
  
  RESULTS
  The duration of central venous catheterization and postoperative hospital stay were significantly longer in the familial amyloidotic polyneuropathy group than they were in the control group. There was no significant difference between modified body mass index preoperatively and 1 year after living-donor liver transplant. Although gastrointestinal symptoms were typically mild before living-donor liver transplant, the familial amyloidotic polyneuropathy group experienced a temporary deterioration in gastrointestinal symptoms after receiving the living-donor liver transplant but recovered after approximately 2 months.
  
  
  CONCLUSIONS
  Although familial amyloidotic polyneuropathy patients experienced temporary exacerbations of gastrointestinal symptoms, their nutritional status was not affected during the peritransplant period, and they generally recovered within 2 months.
authors: Department of Transplantation and Pediatric Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. akarise@fc.kuh.kumamoto-u.ac.jp
authors: Yuki
authors: Y
authors: Ohya
authors: Kaori
authors: K
authors: Isono
authors: Konen
authors: K
authors: Obayashi
authors: Shintaro
authors: S
authors: Hayashida
authors: Kwang-Jong
authors: KJ
authors: Lee
authors: Hidekazu
authors: H
authors: Yamamoto
authors: Takayuki
authors: T
authors: Takeichi
authors: Katsuhiro
authors: K
authors: Asonuma
authors: Yukio
authors: Y
authors: Ando
authors: Yukihiro
authors: Y
authors: Inomata
mesh_terms: D000328:Adult; D028227:Amyloid Neuropathies, Familial / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D015992:Body Mass Index; D002405:Catheterization, Central Venous; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006785:Hospitals, University; D006801:Humans; D007564:Japan; D007902:Length of Stay; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D018529:Nutritional Support; D020127:Recovery of Function; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome