title: Mechanisms of immune evasion in leishmaniasis.
abstract: Diseases caused by Leishmania present a worldwide problem, and current therapeutic approaches are unable to achieve a sterile cure. Leishmania is able to persist in host cells by evading or exploiting host immune mechanisms. A thorough understanding of these mechanisms could lead to better strategies for effective management of Leishmania infections. Current research has focused on parasite modification of host cell signaling pathways, entry into phagocytic cells, and modulation of cytokine and chemokine profiles that alter immune cell activation and trafficking to sites of infection. Immuno-therapeutic approaches that target these mechanisms of immune evasion by Leishmania offer promising areas for preclinical and clinical research.
authors: Department of Pathology, The Ohio State University Medical Center, Columbus, OH, USA; These authors contributed equally to this work.
authors: Gaurav
authors: G
authors: Gupta
authors: Steve
authors: S
authors: Oghumu
authors: Abhay R
authors: AR
authors: Satoskar
mesh_terms: D016207:Cytokines; D006801:Humans; D057131:Immune Evasion; D007891:Leishmania; D007896:Leishmaniasis; D015398:Signal Transduction
chemical_list: D016207:Cytokines