title: S-nitrosoglutathione.
abstract: BACKGROUND
  S-Nitrosoglutathione (GSNO) is the S-nitrosated derivative of glutathione and is thought to be a critical mediator of the down stream signaling effects of nitric oxide (NO). GSNO has also been implicated as a contributor to various disease states.
  
  
  METHODS
  This review focuses on the chemical nature of GSNO, its biological activities, the evidence that it is an endogenous mediator of NO action, and implications for therapeutic use.
  
  
  CONCLUSIONS
  GSNO clearly exerts its cellular actions through both NO- and S-nitrosation-dependent mechanisms; however, the chemical and biological aspects of this compound should be placed in the context of S-nitrosation as a whole.
  
  
  CONCLUSIONS
  GSNO is a central intermediate in formation and degradation of cellular S-nitrosothiols with potential therapeutic applications; thus, it remains an important molecule of study. This article is part of a Special Issue entitled Cellular functions of glutathione.
authors: Department of Biochemistry, Medical College of Wisconsin, WI, USA.
authors: Katarzyna A
authors: KA
authors: Broniowska
authors: Anne R
authors: AR
authors: Diers
authors: Neil
authors: N
authors: Hogg
mesh_terms: D000818:Animals; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism; D015538:Nitrosation; D026422:S-Nitrosoglutathione / Q000737:chemistry / Q000378:metabolism*; D026403:S-Nitrosothiols / Q000737:chemistry / Q000378:metabolism
chemical_list: D026403:S-Nitrosothiols; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione; D005978:Glutathione