title: High single-pass diagnostic yield of a new 25-gauge core biopsy needle for EUS-guided FNA biopsy in solid pancreatic lesions.
abstract: BACKGROUND
  Current limitations of EUS-guided FNA include the need for multiple passes and on-site cytology assessment and lack of core specimen. Recently, a new 25-gauge core biopsy needle (PC25) was developed to overcome these limitations.
  
  
  OBJECTIVE
  To determine the diagnostic yield of EUS-guided FNA aspiration biopsy (FNAB) when using the PC25 needle among patients with solid pancreatic lesions.
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  Academic tertiary referral center.
  
  
  METHODS
  Fifty consecutive patients with a solid pancreatic lesion underwent EUS-guided FNAB with PC25.
  
  
  METHODS
  EUS-guided FNAB with PC25.
  
  
  METHODS
  The primary outcome was the diagnostic yield in single and overall passes of EUS-guided FNAB when using the PC25 needle for pancreatic solid lesions.
  
  
  RESULTS
  Cytologic analysis showed malignancy in 38 patients on the first pass, with a cumulative sensitivity of 83%, 91%, and 96% on passes 1, 2, and 3, respectively. Although visible core was reported in 46 patients (92%), histologic core was seen in 16 patients (32%). Histologic analysis showed malignancy in 29 patients on the first pass, with a cumulative sensitivity of 63% and 87% on pass 1 and passes 1 to 4, respectively. The sensitivity, specificity, and accuracy in combined cytologic and histologic results were 85%, 100%, and 86% for single pass and 96%, 100%, and 96% on multiple passes, respectively. No complications were seen.
  
  
  CONCLUSIONS
  A retrospective study design at a single center using a single arm.
  
  
  CONCLUSIONS
  EUS-guided FNAB with the PC25 needle showed excellent single-pass and overall diagnostic yields. This needle appears to maintain a high cytologic yield, similar to standard 25-gauge FNA needles, while also providing some histologic core tissue.
authors: H.H. Chao Comprehensive Digestive Disease Center, University of California, Irvine Medical Center, Orange, California 92868, USA.
authors: Takuji
authors: T
authors: Iwashita
authors: Yousuke
authors: Y
authors: Nakai
authors: Jason B
authors: JB
authors: Samarasena
authors: Do Hyun
authors: DH
authors: Park
authors: Zesong
authors: Z
authors: Zhang
authors: Mai
authors: M
authors: Gu
authors: John G
authors: JG
authors: Lee
authors: Kenneth J
authors: KJ
authors: Chang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000295:instrumentation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009339:Needles; D018358:Neuroendocrine Tumors / Q000473:pathology*; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult