title: Effects of deranged glucose homeostasis on peripheral arterial stiffness index in patients with pre-diabetes mellitus.
abstract: Premature arteriosclerosis may be one of the mechanisms linking pre-diabetes mellitus (pre-DM) and cardiovascular disease. We sought to characterize premature arteriosclerosis in pre-DM using different arterial stiffness indices and to find the independent contributors of this process. We recruited 33 patients without DM, 53 patients with pre-DM, and 34 subjects with DM. Both the compliance index (CI) and stiffness index (SI) were measured. Patients with pre-DM and DM had lower CI (3.8 ± 2.1 versus 5.2 ± 3.0 units; P < 0.05 and 3.6 ± 1.8 versus 5.2 ± 3.0 units; P < 0.05, respectively) and higher SI (8.0 ± 2.0 versus 6.7 ± 1.6 m/s; P < 0.01 and 9.4 ± 2.3 versus 6.7 ± 1.6 m/s; P < 0.001, respectively) than patients without DM. Using multivariate linear regression analysis, age, heart rate, and HOMA index were independent determinants for SI (whole model: R(2) = 0.47, P < 0.001), whereas male gender, hsCRP, and HOMA index were independent determinants for CI (whole model: R(2) = 0.34, P < 0.01). The HOMA index was an independent determinant for arterial stiffness. Increased insulin resistance may associate with increased arterial stiffness at peripheral arteries in pre-DM patients.
authors: Division of Gastroenterology, Department of Internal Medicine, Tainan Sinlau Hospital, Tainan, Taiwan.
authors: Chang-Hua
authors: CH
authors: Chou
authors: Wei-Chuan
authors: WC
authors: Tsai
authors: Ming-Cheng
authors: MC
authors: Wang
authors: Chin-Shan
authors: CS
authors: Ho
authors: Yi-Heng
authors: YH
authors: Li
authors: Liang-Miin
authors: LM
authors: Tsai
authors: Yau-Sheng
authors: YS
authors: Tsai
authors: Ju-Yi
authors: JY
authors: Chen
mesh_terms: D052242:Adiponectin / Q000032:analysis; D000328:Adult; D000367:Age Factors; D050379:Arteriolosclerosis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006339:Heart Rate; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D059289:Vascular Stiffness
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D002097:C-Reactive Protein