title: Retinal neurovascular coupling in patients with glaucoma and ocular hypertension and its association with the level of glaucomatous damage.
abstract: OBJECTIVE
  To analyze neurovascular coupling in the retina of untreated primary open-angle glaucoma (POAG) and ocular hypertension (OHT) patients.
  
  
  METHODS
  Maximal vessel dilation in response to flicker light was analyzed with Retinal Vessel Analyzer (RVA) in temporal superior/inferior arterioles and veins in 51 POAG patients, 46 OHT and 59 control subjects. RVA parameters were compared between groups, between contralateral POAG eyes, and correlated to intraocular pressure, visual field mean defect and retinal nerve fiber layer thickness.
  
  
  RESULTS
  POAG eyes demonstrated generally smaller response of all vessels to flicker light than the other two groups (ANOVA p=0.026; mean arterial flicker response in percent of baseline, averaged superior and inferior was 3.48 ± 2.22 % for controls , 2.35 ± 2.06 % for POAG patients , and 2.97 ± 2.35 % for OHT patients; corresponding values for venules were 3.88 ± 1.98 %, 2.89 ± 1.72 %, 3.45 ± 2.77 %). There was no difference in flicker response between the eye with more and less advanced damage in each patient of the POAG group (ANOVA p=0.79). Correlation of flicker response to intraocular pressure (IOP) was borderline at best, correlations to the level of glaucomatous damage were not significant. Correlation of flicker response of superior and inferior vessels of the same eye was significant for the arteries (Pearson r=0.23, p=0.004), as well as venules (r=0.52, p<0.001).
  
  
  CONCLUSIONS
  General vessel response to flicker light was decreased in POAG patients, compared to normal controls and OHT patients. In contrast to significant correlation between the two contralateral eyes of the flicker response itself, only its borderline correlation to IOP was seen. There was no correlation to the level of damage, altogether indicating a systemic dysregulation phenomenon. GRANTS: Swiss National Foundation Grant 3200B0-113685, Velux Stiftung Grant, Freie Akademische Gesellschaft (FAG) Grant, Pfizer Inc. Grant CLINICAL TRIAL REGISTRATION REFERENCE NUMBER: ClinicalTrials.gov NCT00430209.
authors: Department of Ophthalmology, University Hospital Basel, University Basel, Mittlerestrasse 91, CH-4031, Basel, Switzerland. Konstantin.Gugleta@usb.ch
authors: K
authors: K
authors: Gugleta
authors: N
authors: N
authors: Waldmann
authors: A
authors: A
authors: Polunina
authors: A
authors: A
authors: Kochkorov
authors: R
authors: R
authors: Katamay
authors: J
authors: J
authors: Flammer
authors: S
authors: S
authors: Orgul
mesh_terms: D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008027:Light; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009798:Ocular Hypertension / Q000503:physiopathology; D009898:Optic Disk / Q000098:blood supply*; D010775:Photic Stimulation; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology; D012171:Retinal Vessels / Q000503:physiopathology* / Q000528:radiation effects; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014794:Visual Fields / Q000502:physiology