title: Dyslipidaemia in chronic kidney disease in Nepalese population.
abstract: Patients having chronic kidney disease (CKD) are at higher risk for cardiovascular disease (CVD). Dyslipidaemia is a potential risk factor for CVD in CKD cases. In this study our aim was to find out the dyslipidaemia in patients with different stages of CKD. This hospital based cross-sectional study was conducted in department of biochemistry, Tribhuvan University Teaching Hospital, Kathmandu, Nepal. Total of 163 CKD cases and 163 non-CKD healthy controls were enrolled.  CKD was defined and classified as per national kidney foundation guidelines. We analyzed fasting lipid profile including total cholesterol, HDL-C, LDL-C and TG. Significant difference in mean value of serum total cholesterol, HDL-C, LDL-C and TG were found in different stage of CKD and non-CKD groups (p value <0.05). CKD cases 33.75% and 21.47% of non-CKD controls had hypercholesterolemia (Odds ratio 1.86, p value 0.013). CKD cases 32.5% and 17.18% of non-CKD controls had low HDL-C (Odds ratio 2.32, P-value 0.001). CKD cases 38.03% and 33.13% of non-CKD controls had high LDL-C (Odds ratio 1.24, p value 0.297). CKD cases 35.58% and 19.01% of non-CKD controls had hypertriglyceridemia (Odds ratio 2.35, P-value 0.001). CKD had a higher prevalence of dyslipidaemia compared to non-CKD controls. Dyslipidaemia was also found in early stages of CKD.
authors: Department of Biochemistry, Manipal College of Medical Sciences, Pokhara, Nepal. bibekclb@yahoo.com
authors: B
authors: B
authors: Poudel
authors: B K
authors: BK
authors: Yadav
authors: B
authors: B
authors: Jha
authors: K B
authors: KB
authors: Raut
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000453:epidemiology*; D015228:Hypertriglyceridemia / Q000097:blood / Q000453:epidemiology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009390:Nepal / Q000453:epidemiology; D012307:Risk Factors; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D014280:Triglycerides; D002784:Cholesterol