title: Relevance of dermatologic radiotherapy in the therapeutic strategy of skin epithelial neoplasms: excellent results in the treatment of lesions localized on eyelids and skin overlying the cartilage of the nose.
abstract: OBJECTIVE
  Epithelial cancer of the skin is the most common human neoplasm. In spite of the multiple modalities of treatment available, about 10 % of these tumours results resistant to them. Therefore, improving the therapeutic strategies is mandatory.
  
  
  METHODS
  A retrospective study has been carried out on 905 patients affected by 986 basal and squamous cell carcinoma, histologically ascertained, localized on eyelids and on skin overlying the cartilages of the nose treated with conventional radiotherapy. All the lesions were classified according to TNM classification.
  
  
  RESULTS
  Follow-up ranged from 1 to 425 months. The five-year cure-rate was 96.38% for eyelids neoplasms and 92.43% for those localized on skin covering nose cartilages, respectively. The percentage of relapse was 5.47%.The graphic representation shows how the risk of relapse remains high for the first five years. On the whole cosmetic and functional outcomes were good.
  
  
  CONCLUSIONS
  Our results confirm dermatologic radiotherapy as a treatment proper to afford very high cure-rates, and support the importance of a correct follow-up. The knowledge of these data and the possibility to compare them with others obtained by different therapies and endowed with histopathologic investigation, TNM classification, adequate follow-up and significant clinical series would result in improvement of the management of skin epithelial neoplasms.
authors: U.O.S. Fotoradioterapia, U.O. Dermatologia Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italia. massimo.caccialanza@policlinico.mi.it
authors: M
authors: M
authors: Caccialanza
authors: R
authors: R
authors: Piccinno
authors: F
authors: F
authors: Gaiani
authors: D
authors: D
authors: Contini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005142:Eyelid Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055171:Nasal Cartilages; D009669:Nose Neoplasms / Q000532:radiotherapy*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000532:radiotherapy*