title: Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid.
abstract: Interleukin (IL)-1 family comprise 11 members that play an important role in immune regulation and inflammatory process. Retinoids exert complex effects on the immune system, having anti-inflammatory effects in chronic dermatological diseases. Vitamin D (vitD) and analogs have been shown to suppress TNF-α-induced IL-1α in human keratinocytes (KCs). In the present study, we investigated IL-1 family members in psoriasis and the effects of vitD and retinoic acid (RA) on these members. We analyzed IL-1 family members gene expression in psoriatic skin and in ex vivo skin organ culture exposed to TNF-α, IL-17 or broadband UVB; afterwards, treatment with vitD or RA was performed and IL-1 family members mRNA was evaluated. Similarly, KCs were stimulated with IL-17 and subsequently treated with vitD. IL-1 family members were enhanced in psoriatic skin and in ex vivo skin organ cultures after pro-inflammatory stimuli (TNF-α, IL-17 and UVB). RA and vitD were able to suppress this enhancement.
authors: Department of Dermatology, University of Naples Federico II, Via Pansini, 5, 80131, Naples, Italy. annabalato@yahoo.it
authors: Anna
authors: A
authors: Balato
authors: Maria
authors: M
authors: Schiattarella
authors: Serena
authors: S
authors: Lembo
authors: Martina
authors: M
authors: Mattii
authors: Nella
authors: N
authors: Prevete
authors: Nicola
authors: N
authors: Balato
authors: Fabio
authors: F
authors: Ayala
mesh_terms: D050071:Bone Density Conservation Agents / Q000494:pharmacology; D002478:Cells, Cultured; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007375:Interleukin-1 / Q000235:genetics / Q000378:metabolism*; D020381:Interleukin-17 / Q000494:pharmacology; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism; D007641:Keratolytic Agents / Q000494:pharmacology; D009924:Organ Culture Techniques; D011565:Psoriasis / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D012867:Skin / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D014466:Ultraviolet Rays / Q000009:adverse effects; D014807:Vitamin D / Q000494:pharmacology*
chemical_list: D050071:Bone Density Conservation Agents; D007375:Interleukin-1; D020381:Interleukin-17; D007641:Keratolytic Agents; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D014807:Vitamin D; D014212:Tretinoin