title: Treatment solutions are unclear for perimegaprosthetic infections.
abstract: BACKGROUND
  Infection about a megaprosthesis is a dreaded complication. Treatment options vary from débridement alone to staged revisions, arthrodesis, and amputation. Indications for how to treat this complication are unclear.
  
  
  OBJECTIVE
  We therefore determined (1) the incidence of perimegaprosthetic infections, (2) the methods of treatment, (3) the number of patients who failed their original treatment plan, and (4) the characteristics of the infection.
  
  
  METHODS
  We retrospectively identified 291 patients who had megaprostheses implanted between 2001 and 2011 and identified all those surgically treated for a perimegaprosthetic infection during that time. We defined a treatment failure as any unplanned reoperation or death due to uncontrolled infection. All patients with failure had a minimum followup of 1 year (mean, 3.3 years; range, 1-8 years).
  
  
  RESULTS
  Of the 291 patients, 31 (11%) had subsequent infections. Surgical management varied among irrigation and débridement (n=15), single-stage revisions (n=11), two-stage revisions (n=4), and amputations (n=1). Sixteen patients failed their original treatment plan: 13 required additional surgery and three died. Infections were mostly chronic and single organism with five being methicillin-resistant Staphylococcus aureus.
  
  
  CONCLUSIONS
  An 11% incidence of perimegaprosthetic infections is consistent with the increased risk of infection seen in other studies. A variety of surgical methods were employed at our institution and by those contributing to the literature without clear evidence of superiority of one method over another. Given the complicated medical and surgical histories of these patients, individualization in decision making is necessary.
  
  
  METHODS
  Level III, therapeutic study. See Instructions for Authors for a complete description of levels of evidence.
authors: Department of Orthopaedics, University of Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA, 15213, USA, ercolanolb@upmc.edu.
authors: Lisa B
authors: LB
authors: Ercolano
authors: Tyson
authors: T
authors: Christensen
authors: Richard
authors: R
authors: McGough
authors: Kurt
authors: K
authors: Weiss
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D003646:Debridement; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants / Q000009:adverse effects*; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D007507:Therapeutic Irrigation; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents