title: The RhoD to centrosomal duplication.
abstract: The main functional roles attributed to the centrosome, the major microtubule organizing center (MTOC) of metazoans, are related to cell locomotion, sensory perception and division. The role of vesicular trafficking in the regulation of the centrosome cycle has been largely unexplored. Recently, however, several studies have indicated the involvement of molecules and/or complexes of the trafficking routes in centrosome positioning, duplication and regulation. Functional screens have revealed communication between the outer nuclear envelope, the Golgi apparatus, the endosomal recycling compartment and centrosomes, while other studies underline the involvement of the ESCRT complex proteins in centrosome function. In this commentary, we discuss our recent study, which shows the involvement of an endosomal Rho protein, namely RhoD, in centrosome duplication and possible links between the centrosome's structural and functional integrity to vesicular trafficking.
authors: Laboratory of Biological Chemistry, University of Ioannina Medical School, Ioannina, Greece.
authors: Athena
authors: A
authors: Kyrkou
authors: Maria
authors: M
authors: Soufi
authors: Ramona
authors: R
authors: Bahtz
authors: Charles
authors: C
authors: Ferguson
authors: Maria
authors: M
authors: Bai
authors: Robert G
authors: RG
authors: Parton
authors: Ingrid
authors: I
authors: Hoffmann
authors: Marino
authors: M
authors: Zerial
authors: Theodore
authors: T
authors: Fotsis
authors: Carol
authors: C
authors: Murphy
mesh_terms: D000818:Animals; D018385:Centrosome / Q000502:physiology*; D016193:G1 Phase / Q000502:physiology*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D016196:S Phase / Q000502:physiology*; D012867:Skin / Q000473:pathology*; D020741:rho GTP-Binding Proteins / Q000235:genetics*
chemical_list: D020741:rho GTP-Binding Proteins
keywords: Rho GTPase; RhoD; centrosome; recycling endosome; trafficking