title: Pneumonitis induced by rifampicin: a case report and literature review.
abstract: An 84-year-old woman being treated for miliary tuberculosis (TB) with rifampicin (RFP), isoniazid (INH), ethambutol (EB) and corticosteroids suffered from a persistent fever for five months. While tapering the dose of prednisolone, chest computed tomography (CT) revealed diffuse ground glass opacities (GGO) and bronchoalveolar lavage fluid (BALF) showed an increase in lymphocytes. After the anti-TB drugs were discontinued and the dose of the corticosteroids was increased, the CT findings and fever improved considerably. However, readministration of RFP provoked an inflammatory reaction, leading to a diagnosis of RFP-induced pneumonitis. This condition is very rare. This is the first report of RFP-induced pneumonitis occurring during adjunct steroid therapy.
authors: Respiratory Center, Shinko Hospital, Japan. yasukok@shinkohp.or.jp
authors: Yasuko
authors: Y
authors: Koma
authors: Keiko
authors: K
authors: Goto
authors: Chihiro
authors: C
authors: Yoshida
authors: Kengo
authors: K
authors: Kimura
authors: Yusuke
authors: Y
authors: Matsumoto
authors: Midori
authors: M
authors: Koyama
authors: Nariyasu
authors: N
authors: Nakashima
authors: Daiki
authors: D
authors: Masuya
authors: Hirofumi
authors: H
authors: Matsuoka
authors: Harukazu
authors: H
authors: Yoshimatsu
authors: Yujiro
authors: Y
authors: Suzuki
mesh_terms: D000369:Aged, 80 and over; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011014:Pneumonia / Q000139:chemically induced*; D012293:Rifampin / Q000009:adverse effects*
chemical_list: D000904:Antibiotics, Antitubercular; D012293:Rifampin