title: Endometrial intraepithelial carcinoma in association with polyp: review of eight cases.
abstract: BACKGROUND
  The uterine endometrial polyp (EMP) has a potential risk of developing malignant tumors especially in postmenopausal women. These malignancies include endometrial intraepithelial carcinoma (EIC).
  
  
  METHODS
  Eight patients with EIC in the EMP, who were postmenopausal with ages ranging from 49 to 76 years (av. 62), were cytologically reviewed in comparison with histological findings.
  
  
  RESULTS
  The endometrial cytological findings were summarized as follows: mucous and watery diathesis as a background lacking or with little necrotic inflammatory changes; micropapillary cluster formation; abrupt transition between carcinoma cells and normal cells; nuclear enlargement; high N/C ratio; and single or a few prominent nucleoli. Histologically, one case had EIC alone in the EMP; three cases had EIC with stromal invasion confined to the EMP; and four cases had EIC in the atrophic endometrium in addition to EIC in the EMP. Seven patients have taken a disease-free course after surgical resection, but one patient died 44 months following the initial diagnosis because of the massive tumor extending over her peritoneal cavity.
  
  
  CONCLUSIONS
  Endometrial cytology may be helpful for the detection of early endometrial adenocarcinomas with serous features including EIC. Some early stage endometrial adenocarcinomas represented by EIC exceptionally take an aggressive clinical course irrespective of a lack of extrauterine lesions.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1651876760876449.
authors: Department of Pathology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, Japan. m_yasuda@saitama-med.ac.jp
authors: Masanori
authors: M
authors: Yasuda
authors: Tomomi
authors: T
authors: Katoh
authors: Shinichi
authors: S
authors: Hori
authors: Kimiyoshi
authors: K
authors: Suzuki
authors: Kisaku
authors: K
authors: Ohno
authors: Masanori
authors: M
authors: Maruyama
authors: Naruaki
authors: N
authors: Matsui
authors: Sayuri
authors: S
authors: Miyazaki
authors: Naoki
authors: N
authors: Ogane
authors: Yoichi
authors: Y
authors: Kameda
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D055088:Early Detection of Cancer; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D011127:Polyps / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D013997:Time Factors; D016896:Treatment Outcome