title: Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensis.
abstract: In this study, we investigated the antinociceptive effect of 7-methoxyflavone (7MF) in mice using the following tests: acetic acid-induced writhing, glutamate- and formalin-induced nociception and hotplate. 7MF (30, 50, 100 and 300 μmol/kg, i.p.) reduced the number of writhes, with ID₅₀ = 82.5 ± 11.7 μmol/kg and E max = 58.4%. 7MF treatment (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase. In addition, in glutamate-induced nociception, 7MF inhibited 26% of the nociceptive answer. On the other hand, 7MF did not increase the latency time of the animals in the hotplate test. These results suggest that 7MF has peripheral antinociceptive activity.
authors: a Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa , Paraíba , Brazil.
authors: Anne Dayse Soares
authors: AD
authors: da Silva
authors: Luiz Henrique Agra
authors: LH
authors: Cavalcante-Silva
authors: Carolina B Brito
authors: CB
authors: da Matta
authors: Diego de Farias
authors: Dde F
authors: Silva
authors: Morgana Vital de
authors: MV
authors: Araújo
authors: Josean F
authors: JF
authors: Tavares
authors: Marcelo S
authors: MS
authors: da Silva
authors: Magna Suzana
authors: MS
authors: Alexandre-Moreira
mesh_terms: D000818:Animals; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D047309:Flavones / Q000737:chemistry*; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D047309:Flavones; D010936:Plant Extracts; C525137:7-methoxyflavone