title: Histopathological classification and location of consecutively operated meningiomas at a single institution in China from 2001 to 2010.
abstract: BACKGROUND
  Meningioma is one of the most common primary tumors of the central nervous system, but there are not many detailed studies on the sex, age, subtypes and locations of large series. This study was a retrospective analysis of the characteristics of meningioma cases consecutively operated on at a single institution in China from 2001 to 2010.
  
  
  METHODS
  This study investigated the demographic background of 7084 meningioma cases, and the subtypes and locations of the tumors. Sex and age distributions were analyzed, and the pathological subtypes were classified according to the World Health Organization (WHO) classification. The location of the meningiomas was also categorized.
  
  
  RESULTS
  The female:male ratio of the 7084 cases was 2.34:1. The mean age was 51.4 years (range, 11 months-86 years). The mean age of cases of WHO grade I meningioma was significantly older than that of grade II or III meningiomas (P < 0.001, Fisher's Least Significant Digit test). There was a significantly higher female:male ratio in WHO grade I meningiomas than in grade II or grade III meningiomas (2.57, 1.03 and 0.76, respectively; P < 0.001, χ(2) test). Meningothelial (n = 2061) and fibrous meningiomas (n = 3556) were the most common subtypes, comprising 79.3% of all meningiomas. All meningioma cases were classified into 23 locations in this study, with the cerebral convexity the most common site (38.33%, n = 2722). Cases with uncommon locations such as extra-cranial and sylvian fissure meningiomas were also present in this series.
  
  
  CONCLUSIONS
  Female predominance was found for benign meningiomas, while malignant subtypes showed male predominance. The mean age of patients with WHO grade I meningiomas was older than that of patients with higher-grade tumors. Meningothelial and fibrous meningiomas were the most common subtypes. The cerebral convexity was the most common meningioma location.
authors: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Dai-jun
authors: DJ
authors: Wang
authors: Qing
authors: Q
authors: Xie
authors: Ye
authors: Y
authors: Gong
authors: Ying
authors: Y
authors: Mao
authors: Yin
authors: Y
authors: Wang
authors: Hai-xia
authors: HX
authors: Cheng
authors: Ping
authors: P
authors: Zhong
authors: Xiao-ming
authors: XM
authors: Che
authors: Cheng-chuan
authors: CC
authors: Jiang
authors: Feng-ping
authors: FP
authors: Huang
authors: Kang
authors: K
authors: Zheng
authors: Shi-qi
authors: SQ
authors: Li
authors: Yu-xiang
authors: YX
authors: Gu
authors: Wei-min
authors: WM
authors: Bao
authors: Bo-jie
authors: BJ
authors: Yang
authors: Jing-song
authors: JS
authors: Wu
authors: Li-qian
authors: LQ
authors: Xie
authors: Ming-zhe
authors: MZ
authors: Zheng
authors: Hai-liang
authors: HL
authors: Tang
authors: Hong-da
authors: HD
authors: Zhu
authors: Xian-cheng
authors: XC
authors: Chen
authors: Liang-fu
authors: LF
authors: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008579:Meningioma / Q000453:epidemiology*; D008875:Middle Aged; D017678:Sex Distribution; D055815:Young Adult