title: [Lewy body disease, a frequent dementia].
abstract: Dementia with Lewy bodies is probably the second most frequent neurodegenerative dementia. Its neuropathological features overlap those of both Parkinson's disease and Alzheimer's disease, and the neuropathological hallmarks are therefore uncertain. Dementia with Lewy bodies is rather a clinical syndrome than a "neuropathological diagnosis". A combination of six original but non specific features is useful for diagnosis, namely fluctuating attention and cognition; recurrent daytime well-formed and detailed visual hallucinations; features of parkinsonism; rapid eye movement sleep behavior disorders; severe neuroleptic sensitivity; and low dopamine uptake in the basal ganglia. Because of the therapeutic implications, diagnosis of dementia with Lewy bodies is an important challenge.
authors: Centre M6moire de Ressource et de Recherche, Inserm U1077. delasayette-v@chu-caen.fr
authors: Vincent
authors: V
authors: de la Sayette
authors: Fausto
authors: F
authors: Viader
authors: Françoise
authors: F
authors: Chapon
mesh_terms: D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D006801:Humans; D020961:Lewy Body Disease / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy; D059906:Neuroimaging
chemical_list: D002800:Cholinesterase Inhibitors