title: The origins and drivers of insulin resistance.
abstract: Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which precedes the development of type 2 diabetes mellitus and is thus the driving force behind the emerging diabetes epidemic. The precise causes of insulin resistance are varied, and the relative importance of each is a matter of ongoing research. Here, we offer a Perspective on the heterogeneous etiology of insulin resistance, focusing in particular on the role of inflammation, lipid metabolism, and the gastrointestinal microbiota.
authors: Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0673, USA.
authors: Andrew M F
authors: AM
authors: Johnson
authors: Jerrold M
authors: JM
authors: Olefsky
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008264:Macrophages / Q000378:metabolism; D009765:Obesity / Q000378:metabolism