title: Alterations of platelet function and coagulation parameters during acute pancreatitis.
abstract: Vascular thrombosis and systemic hypercoagulable states are known complications of pancreatitis. Higher levels of mean platelet volume (MPV) have been associated with thrombotic diseases. However, a few studies have investigated the association between acute pancreatitis and MPV. We aimed to investigate whether there is a difference of MPV and coagulation parameters in patients with active and remission in acute pancreatitis. We included 24 consecutive patients with biliary acute pancreatitis and 24 consecutive healthy age-matched and sex-matched controls. Full blood counts and other laboratory tests were collected at onset and remission. The MPV was significantly higher in patients with acute pancreatitis at admission 8.6±1.4 fl than controls 7.6±0.7 fl (P=0.005). We detected positive correlation between, aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, amylase, lipase, and glucose, BMI, D-dimer and MPV. However, there was negative correlation between progression, thrombocyte counts, hemoglobin and MPV. As a result higher MPV levels in acute pancreatitis may reflect hypercoagulation associated with pancreatitis.
authors: Department of Gastroenterology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. drerdemakbal@gmail.com
authors: Erdem
authors: E
authors: Akbal
authors: Selim
authors: S
authors: Demirci
authors: Erdem
authors: E
authors: Koçak
authors: Seyfettin
authors: S
authors: Köklü
authors: Omer
authors: O
authors: Başar
authors: Yaşar
authors: Y
authors: Tuna
mesh_terms: D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D015992:Body Mass Index; D016022:Case-Control Studies; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000473:pathology; D015539:Platelet Activation; D010976:Platelet Count
chemical_list: D015415:Biomarkers