title: The role of sibutramine in weight reduction.
abstract: BACKGROUND
  The effectiveness of pharmacologic support with sibutramine along with the preservation of dietary and regimen measures is shown in a group of long-term treated patients at the Metabolic Clinic of the University Hospital in Hradec Králové.
  
  
  METHODS
  In ambulatory patients, basic anthropometric parameters as body weight, BMI, waist circumference and the total amount of adipose tissue were compared before substitution with 10 mg sibutramine and after a four-month therapy. This group included 94 patients who were administered the same dose of sibutramine for the whole period of time. This group consisted of 37 men and 57 women.
  
  
  RESULTS
  After a four-month therapy with sibutramine there was a mean reduction in weight by 7.9 ± 3.8 kg in the monitored group of patients. Their BMI was reduced by 2.3 ± 1.5 kg/height2 and the waist circumference by 4.4 ± 3.8 cm. The decrease in the percentage of the total body lipid was 2.9 %.
  
  
  CONCLUSIONS
  Despite a surprising decision of the European Drug Agency to suspend the registration of sibutramine in the whole of Europe since January 2010 we can state that in our patients we have proven a positive effect of sibutramine substitution on their weight reduction (Tab. 1, Ref. 19).
authors: University of Defence, Faculty of Military Health Services, Department of Military Hygiene, Hradec Kralove, Czech Republic.
authors: V
authors: V
authors: Pavlik
authors: J
authors: J
authors: Fajfrova
authors: L
authors: L
authors: Slovacek
authors: E
authors: E
authors: Drahokoupilova
mesh_terms: D000328:Adult; D000368:Aged; D001067:Appetite Depressants / Q000627:therapeutic use*; D003503:Cyclobutanes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D015431:Weight Loss / Q000187:drug effects*; D055815:Young Adult
chemical_list: D001067:Appetite Depressants; D003503:Cyclobutanes; C058254:sibutramine