title: Effects of manganese deficiency on serum hormones and biochemical markers of bone metabolism in chicks.
abstract: In order to investigate the effect of manganese (Mn) deficiency on bone metabolism in chicks, ninety 1-day-old male Arbor Acre chicks were randomly divided into 3 groups and each group were given a diet having a different concentration of Mn (60 mg kg(-1), control group; 40 mg kg(-1), Mn-deficient group I; 8.7 mg kg(-1), Mn-deficient group II). The serum was collected at 42 days old. Tests were performed to evaluate the changes in the levels of PTH, CT, ALP, TrACP, HOP TNF-alpha, OC, Mn and Ca in the serum of the chicks and the results showed that the levels of CT, ALP, TrACP, HOP, and Mn decreased markedly (P < 0.05), while PTH, Ca, and TNF-alpha increased markedly (P < 0.05) due to manganese deficiency in the diet, which indicates that Mn deficiency results in disorder of bone regulatory hormones and enzymes of bone metabolism in the serum.
authors: College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 271018, Taian, Shandong, People's Republic of China.
authors: Wang
authors: W
authors: Zhaojun
authors: Wang
authors: W
authors: Lin
authors: Wang
authors: W
authors: Zhenyong
authors: Wang
authors: W
authors: Jian
authors: Liu
authors: L
authors: Ran
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000097:blood; D002645:Chickens / Q000097:blood* / Q000378:metabolism*; D006728:Hormones / Q000097:blood*; D006909:Hydroxyproline / Q000097:blood; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008345:Manganese / Q000172:deficiency* / Q000378:metabolism; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D000071681:Tartrate-Resistant Acid Phosphatase; D013977:Tibia / Q000002:abnormalities / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D006728:Hormones; D007527:Isoenzymes; D010281:Parathyroid Hormone; D014409:Tumor Necrosis Factor-alpha; D015675:Osteocalcin; D008345:Manganese; D002116:Calcitonin; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D006909:Hydroxyproline; D002118:Calcium