title: Trichosporon asahii sepsis in a patient with pediatric malignancy.
abstract: Trichosporon asahii is a rare opportunistic infection, especially in children, causing a life-threatening fungal infection underlying hematologic malignancies. Predisposing factors for infection with this pathogen are immunodeficiency including underlying malignancy, organ transplantation, extensive burns, human immunodeficiency virus infection, corticosteroid therapy, prosthetic valve surgery, and peritoneal dialysis. In the literature, a breakthrough under caspofungin, micafungin therapy is reported. In this article we report on a 16-year-old patient with Ewing sarcoma who had T. asahii sepsis. The patient died although he had been receiving caspofungin for less than 3 months and amphotericin B therapy for 3 days. A postmortem study of conchal tissues revealed T. asahii and mucormycosis histopathologically, and blood culture grew T. asahii.
authors: Department of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: Aslinur
authors: A
authors: Ozkaya-Parlakay
authors: Department of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: dredakaradag@gmail.com.
authors: Eda
authors: E
authors: Karadag-Oncel
authors: Department of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: Ali Bulent
authors: AB
authors: Cengiz
authors: Department of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: Ates
authors: A
authors: Kara
authors: Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: Atilla
authors: A
authors: Yigit
authors: Department of Pediatric Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: Safak
authors: S
authors: Gucer
authors: Department of Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: Deniz
authors: D
authors: Gur
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D007762:Labyrinthitis / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008297:Male; D012512:Sarcoma, Ewing / Q000150:complications*; D018805:Sepsis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D014250:Trichosporon / Q000145:classification / Q000302:isolation & purification*; D060586:Trichosporonosis / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*
chemical_list: D000935:Antifungal Agents
keywords: Child; Sepsis; Trichosporon asahii