title: [A case of recurrent breast cancer with multiple bone metastasis successfully treated with S-1 and zoledronic acid therapy].
abstract: For a case of recurrent breast cancer with multiple bone metastasis, an oral pyrimidine fluoride-based anti-cancer drug S -1, and zoledronic acid(a third-generation bisphosphonate formulation), were prescribed in experiments to test their efficacy. S-1 was prescribed orally at doses of 100 mg/day(twice)over a 4-week period with a cessation period of 2 weeks. Zoledronic acid was commenced with a strict administration of 4 mg every 4 weeks, taken intravenously. At the conclusion of the 1st S-1 course, the tumor markers began to improve to a certain extent with an improvement in the symptoms. Following the 16 courses, there was no abnormal accumulation detected by PET. Now, at the end of the 21st course, the treatment is being continued, and there has been no recurrence of inflammation or reoccurring growth detected. No adverse effects of more than Grade 1 occurred during the elapsed process. As a form of combined therapy, we can expect zoledronic acid to be a good anti-cancer drug because of its effectiveness and tolerability in treating recurring breast cancer.
authors: Dept. of Breast and Endocrine Surgery, Ishikawa Prefectural Central Hospital.
authors: Tomomi
authors: T
authors: Murata
authors: Hiroshi
authors: H
authors: Yoshino
authors: Mami
authors: M
authors: Kaneko
authors: Tetsuji
authors: T
authors: Yamada
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004164:Diphosphonates / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D010094:Oxonic Acid / Q000008:administration & dosage; D012008:Recurrence; D005641:Tegafur / Q000008:administration & dosage; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D004338:Drug Combinations; D007093:Imidazoles; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077211:Zoledronic Acid