title: Multifunctional carboxymethyl cellulose-based magnetic nanovector as a theragnostic system for folate receptor targeted chemotherapy, imaging, and hyperthermia against cancer.
abstract: A multifunctional biocompatible nanovector based on magnetic nanoparticle and carboxymethyl cellulose (CMC) was developed. The nanoparticles have been characterized using TEM, SEM, DLS, FT-IR spectra, VSM, and TGA studies. We found that the synthesized carboxymethyl cellulose magnetic nanoparticles (CMC MNPs) were spherical in shape with an average size of 150 nm having low aggregation and superparamagnetic properties. We found that the folate-tagged CMC MNPs were delivered to cancer cells by a folate-receptor-mediated endocytosis mechanism. 5-FU was encapsulated as a model drug for delivering cytotoxicity, and we could demonstrate the sustained release of 5-FU. It was also observed that the FITC-labeled CMC MNPs could effectively enter cells, and the fate of nanoparticles was tracked with Lysotracker. The CMC MNPs could induce significant cell death when an alternating magnetic field was applied. These results indicate that the multifunctional CMC MNPs possess a high drug loading efficiency and high biocompatibility and with low cell cytotoxicity and can be considered to be promising candidates for CMC-based targeted drug delivery, cellular imaging, and magnetic hyperthermia (MHT).
authors: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan.
authors: Balasubramanian
authors: B
authors: Sivakumar
authors: Ravindran Girija
authors: RG
authors: Aswathy
authors: Yutaka
authors: Y
authors: Nagaoka
authors: Masashi
authors: M
authors: Suzuki
authors: Takahiro
authors: T
authors: Fukuda
authors: Yasuhiko
authors: Y
authors: Yoshida
authors: Toru
authors: T
authors: Maekawa
authors: Dasappan Nair
authors: DN
authors: Sakthikumar
mesh_terms: D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016650:Fluorescein-5-isothiocyanate; D005472:Fluorouracil / Q000737:chemistry / Q000494:pharmacology; D058973:Folate Receptors, GPI-Anchored; D006801:Humans; D006979:Hyperthermia, Induced; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D058973:Folate Receptors, GPI-Anchored; D016650:Fluorescein-5-isothiocyanate; D002266:Carboxymethylcellulose Sodium; D005472:Fluorouracil