title: Prediabetes is associated with a high-risk colorectal adenoma.
abstract: BACKGROUND
  Type 2 diabetes mellitus is associated with an increased risk of colorectal neoplasia. However, association between prediabetes and colorectal adenoma has not been reported.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the relationship between prediabetes and the presence of colorectal adenomas.
  
  
  METHODS
  Consecutive prediabetic subjects who underwent screening colonoscopy were enrolled at Kyung Hee University Hospital in Gangdong, Seoul, Korea, between June 2006 and May 2012. Non-prediabetic subjects were separately pooled from the database of the Center for Health Promotion between January 2012 and May 2012. Prediabetes was defined according to the recommendations of the American Diabetes Association. The prevalence of colorectal adenomas and their characteristics were compared between prediabetic and non-prediabetic groups.
  
  
  RESULTS
  The prevalence of colorectal adenoma was higher in prediabetic subjects than in non-prediabetic subjects (39.6 vs. 30.6 %, respectively, p = 0.019). Prediabetic subjects had more multiple and high-risk adenomas than the control group in non-matched analysis (p = 0.000, respectively). In age-matched analysis, the prevalence of multiple and high-risk adenomas were significantly higher in a prediabetic group than those in a control group (44.4 vs. 28.4 %, p = 0.034; 51.9 vs. 34.6 %, p = 0.026, respectively). Furthermore, prediabetes (odds ratio = 2.198; 95 % confidence interval = 1.042-4.637; p = 0.039) was found to be an independent risk factor for a high-risk adenoma by multivariate analysis.
  
  
  CONCLUSIONS
  The prevalence of multiple and high-risk colorectal adenomas is significantly higher in the prediabetic subjects than those in the control group. Furthermore, prediabetes was found to be an independent risk factor for a high-risk colorectal adenoma.
authors: Department of Internal Medicine, Kyung Hee University College of Medicine, Gang Dong Kyung Hee University Hospital, 149 Sangil-dong, Gangdong-gu, Seoul 134-727, South Korea. drcha@khu.ac.kr
authors: Jae Myung
authors: JM
authors: Cha
authors: Joung Il
authors: JI
authors: Lee
authors: Kwang Ro
authors: KR
authors: Joo
authors: Hyun Phil
authors: HP
authors: Shin
authors: Jung Won
authors: JW
authors: Jeun
authors: Jun Uk
authors: JU
authors: Lim
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D016022:Case-Control Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011236:Prediabetic State / Q000150:complications*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors