title: Iridium-catalyzed selective α-alkylation of unactivated amides with primary alcohols.
abstract: The first α-alkylation of unactivated amides with primary alcohols is described. An effective and robust iridium pincer complex has been developed for selective α-alkylation of tertiary and secondary acetamides involving a "borrowing hydrogen" methodology. The method is compatible with alcohols bearing various functional groups. This presents a convenient and environmentally benign protocol for α-alkylation of amides.
authors: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032, China.
authors: Le
authors: L
authors: Guo
authors: Yinghua
authors: Y
authors: Liu
authors: Wubing
authors: W
authors: Yao
authors: Xuebing
authors: X
authors: Leng
authors: Zheng
authors: Z
authors: Huang
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000577:Amides; D007495:Iridium