title: Fibroblast growth factor-2, bone homeostasis and fracture repair.
abstract: There remains a great need to develop therapeutic agents to treat critical size defects and non-union fractures and one of the potential agents is recombinant human fibroblast growth factor 2 (FGF-2). We discuss the function of FGF-2 in bone formation, bone resorption, and downstream signaling pathways and review the role of exogenous FGF-2 in fracture healing. The importance of endogenous FGF-2 in bone formation and its potential importance in fracture healing in response to parathyroid hormone (PTH) and bone morphogenetic protein 2 (BMP2) is described. In addition we will review, FGF-2 signaling crosstalk with Wnt signaling and PTH signaling in bone formation and repair. Finally, we discuss the outstanding unresolved issues in the application of FGF-2 as therapeutic agent for bone regeneration.
authors: Department of Medicine, University of Connecticut School of Medicine, 263 Farmington Ave., Farmington, CT 06030, USA. hurley@nso1.uchc.edu
authors: Yurong
authors: Y
authors: Fei
authors: Gloria
authors: G
authors: Gronowicz
authors: Marja M
authors: MM
authors: Hurley
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use*; D017102:Fracture Healing / Q000187:drug effects / Q000502:physiology*; D050723:Fractures, Bone / Q000188:drug therapy* / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D010281:Parathyroid Hormone / Q000378:metabolism / Q000502:physiology / Q000627:therapeutic use; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism / Q000502:physiology
chemical_list: D010281:Parathyroid Hormone; D051153:Wnt Proteins; D016222:Fibroblast Growth Factor 2