title: Total synthesis of two possible diastereomers of (+)-sarcophytonolide C and its structural elucidation.
abstract: Stereoselective and parallel total syntheses of two possible diastereomers of (+)-sarcophytonolide C have been accomplished. Macrolactonization and transannular ring-closing metathesis (RCM) were the key transformations. Detailed comparisons of their (1)H and (13)C NMR data and specific rotation with those of the natural product allowed the absolute configuration of (+)-sarcophytonolide C to be determined.
authors: Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan. takamura@cc.okayama-u.ac.jp
authors: Hiroyoshi
authors: H
authors: Takamura
authors: Kohei
authors: K
authors: Iwamoto
authors: Eiji
authors: E
authors: Nakao
authors: Isao
authors: I
authors: Kadota
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D004224:Diterpenes; C581724:sarcophytonolide C