title: Association of apolipoprotein A-V concentration with apolipoprotein A5 gene -1131T>C polymorphism and fasting triglyceride levels.
abstract: OBJECTIVE
  The relationship between the apolipoprotein A5 gene (APOA5) -1131T>C polymorphism and triglyceride levels is well established, but the association between circulating apolipoprotein A-V (apoA-V) concentrations and APOA5 -1131T>C genotypes and triglyceride levels remains controversial.
  
  
  METHODS
  Normotriglyceridemic controls (n = 1526) and hypertriglyceridemic cases (n = 744) were genotyped for APOA5-1131T>C. ApoA-V, triglycerides, insulin, free fatty acids, and lipoprotein profiles were analyzed.
  
  
  RESULTS
  APOA5-1131C minor allele frequency was significantly greater in hypertriglyceridemic patients than normotriglyceridemic controls. ApoA-V concentrations were not significantly different between controls and cases. Normotriglyceridemic controls with T/C and C/C showed lower apoA-V concentrations (14% and 27%, respectively), than did T/T controls. Similar genotypic effects on apoA-V were found in hypertriglyceridemic cases. In both groups, APOA5-1131T>C was associated with higher triglycerides, smaller LDL particle size, and lower HDL-cholesterol. We observed a negative correlation between apoA-V and triglyceride in controls and a positive correlation in hypertriglyceridemic patients, regardless of genotype. We observed a positive correlation between apoA-V and free fatty acids in both groups, regardless of genotype, and a positive correlation between apoA-V and HDL-cholesterol in controls (T/T, T/C, or C/C) and hypertriglyceridemic patients (T/T or T/C).
  
  
  CONCLUSIONS
  APOA5-1131C may lead to reduced apoA-V with concomitantly reduced lipoprotein lipase activation, resulting in greater serum triglycerides, although the correlation between apoA-V and triglyceride was reversed when triglyceride was greater than 150 mg/dL.
authors: Department of Food and Nutrition, National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, College of Human Ecology, Yonsei University, Seoul, Korea.
authors: Jin Young
authors: JY
authors: Kim
authors: Oh Yoen
authors: OY
authors: Kim
authors: Jean Kyung
authors: JK
authors: Paik
authors: Sang-Hyun
authors: SH
authors: Lee
authors: Jong Ho
authors: JH
authors: Lee
mesh_terms: D000072040:Apolipoprotein A-V; D001053:Apolipoproteins / Q000097:blood*; D001054:Apolipoproteins A / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000235:genetics / Q000473:pathology; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood*
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001053:Apolipoproteins; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides; D008071:Lipoprotein Lipase