title: Approval of a tuberculosis drug based on a paradoxical surrogate measure.
authors: Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA. javorn@medsoc.harvard.edu
authors: Jerry
authors: J
authors: Avorn
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015415:Biomarkers; D064687:Diarylquinolines; D017277:Drug Approval; D004345:Drug Industry; D004348:Drug Labeling; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D011804:Quinolines / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D018401:Sample Size; D013183:Sputum / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D000995:Antitubercular Agents; D015415:Biomarkers; D064687:Diarylquinolines; D011804:Quinolines; C493870:bedaquiline