title: Comparative study on hypocholesterolemic and antioxidant activities of various extracts of fenugreek seeds.
abstract: The hypocholesterolemic and antioxidant activities of various extracts (water, methanol, ethyl acetate, hexane, dichloro-methane) of fenugreek seeds were investigated in cholesterol-fed rats. Only the ethyl acetate extract reduced total cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) and increased high-density lipoprotein cholesterol (HDL-C) compared with those of rats fed a cholesterol-rich diet (HCD). Furthermore, the content of thiobarbituric acid-reactive substances (TBARS), and catalase and superoxide dismutase (SOD) in liver, heart and kidney decreased significantly after oral administration of the ethyl acetate extract, compared with those of HCD-fed rats. The phenolic and flavonoïd contents were highest in the methanol and the ethyl acetate extracts. These results showed that the ethyl acetate extract of the fenugreek seeds had a significant hypocholesterolemic effect and antioxidant activity in cholesterol-fed rats, whether this is partly due to the presence of flavonoïds in the extract needs further study.
authors: Unité de recherche DGRST 02-08/20, Laboratoire de Biochimie, Faculté de Médecine de Sfax, Tunisia. olfahadriche@yahoo.com
authors: Olfa
authors: O
authors: Belguith-Hadriche
authors: Mohamed
authors: M
authors: Bouaziz
authors: Kamel
authors: K
authors: Jamoussi
authors: Monique S J
authors: MS
authors: Simmonds
authors: Abdelfattah
authors: A
authors: El Feki
authors: Fatma
authors: F
authors: Makni-Ayedi
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage* / Q000737:chemistry; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D029910:Trigonella / Q000737:chemistry*
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D013482:Superoxide Dismutase