title: A highly enantioselective four-component reaction for the efficient construction of chiral β-hydroxy-α-amino acid derivatives.
abstract: An enantioselective four-component reaction of a diazoketone, water, an aniline and ethyl glyoxylate in the presence of catalytic Rh2(OAc)4 and a chiral Brønsted acid was developed to efficiently produce β-hydroxy-α-amino acid derivatives in good yields with high diastereoselectivity and enantioselectivity.
authors: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, 200062 China.
authors: Yu
authors: Y
authors: Qian
authors: Changcheng
authors: C
authors: Jing
authors: Shunying
authors: S
authors: Liu
authors: Wenhao
authors: W
authors: Hu
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D006038:Glyoxylates / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000596:Amino Acids; D000814:Aniline Compounds; D006038:Glyoxylates; D007659:Ketones; D014867:Water; C023650:aniline