title: Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors.
abstract: Children with solid tumors, most of which are malignant, have an excellent prognosis when treated on contemporary regimens. These regimens, which incorporate chemotherapeutic agents and treatment modalities used for many decades, have evolved to improve relapse-free survival and reduce long-term toxicity. This review discusses the evolution of the treatment regimens employed for management of the most common solid tumors, emphasizing the similarities between contemporary and historical regimens. These similarities allow the use of historical patient cohorts to identify the late effects of successful therapy and to evaluate remedial interventions for these adverse effects.
authors: Department of Epidemiology, St. Jude Children's Research Hospital Memphis, Memphis, Tennessee 38105-2794, USA. daniel.green@stjude.org
authors: Daniel M
authors: DM
authors: Green
authors: Larry E
authors: LE
authors: Kun
authors: Katherine K
authors: KK
authors: Matthay
authors: Anna T
authors: AT
authors: Meadows
authors: William H
authors: WH
authors: Meyer
authors: Paul A
authors: PA
authors: Meyers
authors: Sheri L
authors: SL
authors: Spunt
authors: Leslie L
authors: LL
authors: Robison
authors: Melissa M
authors: MM
authors: Hudson
mesh_terms: D002648:Child; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009369:Neoplasms / Q000266:history* / Q000628:therapy*