title: The influence of selective vitamin D receptor activator paricalcitol on cardiovascular system and cardiorenal protection.
abstract: The ubiquitous distribution of vitamin D receptors in the human body is responsible for the pleiotropic effects of vitamin D-receptor activation. We discuss the possible beneficial effects of a selective activator of vitamin D receptor, paricalcitol, on the cardiovascular system in chronic heart failure patients and chronic kidney patients, in light of new trials. Paricalcitol should provide additional clinical benefits over the standard treatment for chronic kidney and heart failure, especially in cases of cardiorenal syndrome.
authors: Department of Cardiology, School of Medicine in Split, University Hospital Split, Split, Croatia.
authors: Darko
authors: D
authors: Duplancic
authors: Marijan
authors: M
authors: Cesarik
authors: Nikola Kolja
authors: NK
authors: Poljak
authors: Maja
authors: M
authors: Radman
authors: Vedran
authors: V
authors: Kovacic
authors: Josipa
authors: J
authors: Radic
authors: Veljko
authors: V
authors: Rogosic
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use*; D059347:Cardio-Renal Syndrome / Q000188:drug therapy / Q000503:physiopathology; D002319:Cardiovascular System / Q000187:drug effects; D002908:Chronic Disease; D004872:Ergocalciferols / Q000494:pharmacology / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D018167:Receptors, Calcitriol / Q000819:agonists*; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D050071:Bone Density Conservation Agents; D004872:Ergocalciferols; D018167:Receptors, Calcitriol; C084656:paricalcitol
keywords: albuminuria; cardiovascular system; inflammation; vitamin D deficiency