title: Primary submucosal nodular plasmacytoma of the stomach: a poorly recognized variant of gastric lymphoma.
abstract: Gastric plasmacytoma (GP) is a rare variant of gastric lymphomas. In the exceptional event that a patient presents with GP, the lesion occupies the mucosal layer in the vast majority of cases. Here we report a case of nodular plasmacytoma confined to the submucosa with no evidence of Helicobacter pylori (Hp) infection. The patient was a 59-year old female presenting with no particular symptoms. The tumor was well-demarcated and consisted of a diffuse monomorphic proliferation of plasma cells with numerous lymphoid follicles scattered throughout the tumor. The mucosal surface was intact and not associated with any tumor nodules. The cells were diffusely positive for CD79a, Bob1, EMA and IgA and consistently negative for CD3, CD19, CD20, PAX5, CD56, IgM and IgG. Additionally, in situ hybridization demonstrated clonality in the form of λ light-chain restriction. This submucosal nodular proliferation pattern of plasmacytoma is poorly recognized and considered to be a novel variant of lymphoma.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3489998708673079.
authors: Department of Diagnostic Pathology, Kobe University Hospital, Hyogo, Japan. makiron@med.kobe-u.ac.jp
authors: Maki
authors: M
authors: Kanzawa
authors: Chihoko
authors: C
authors: Hirai
authors: Yukiko
authors: Y
authors: Morinaga
authors: Fumi
authors: F
authors: Kawakami
authors: Shigeo
authors: S
authors: Hara
authors: Hiroshi
authors: H
authors: Matsuoka
authors: Tomoo
authors: T
authors: Itoh
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D049109:Cell Proliferation; D016145:Endoscopy, Digestive System; D005260:Female; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D050439:Genes, Immunoglobulin Light Chain; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000235:genetics; D008224:Lymphoma, Follicular / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D010954:Plasmacytoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D013274:Stomach Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D007146:Immunoglobulin lambda-Chains