title: Ubiquitination signals critical to regulatory T cell development and function.
abstract: Protein ubiquitination has emerged as a crucial modulator of the immune system, participating in the control of T cell differentiation, intracellular signal transduction and the induction of immune tolerance. CD4(+)CD25(+)FOXP3(+) regulatory T cells are a unique subset of cells that mediate central and peripheral immune tolerance. In this review, we highlight our current understanding of the molecular mechanisms and signaling pathways that modulate protein ubiquitination in Treg cells, and how ubiquitination determines Treg cell development and function. Understanding how FOXP3 activity is regulated by ubiquitination and deubiquitination under molecular level will promote regulatory T cell therapy for treating inflammation in autoimmune disease, infection, transplantation and cancer.
authors: Key Laboratory of Molecular Virology & Immunology, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 411 Hefei Road, Shanghai, 200025, China.
authors: Zuojia
authors: Z
authors: Chen
authors: Xuerui
authors: X
authors: Luo
authors: Ye
authors: Y
authors: Lu
authors: Tao
authors: T
authors: Zhu
authors: Jinhu
authors: J
authors: Wang
authors: Andy
authors: A
authors: Tsun
authors: Bin
authors: B
authors: Li
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D000074749:Deubiquitinating Enzyme CYLD; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D050721:Proto-Oncogene Proteins c-cbl / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism; D044763:Ubiquitin-Conjugating Enzymes / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins; C471607:UBE2N protein, human; D044763:Ubiquitin-Conjugating Enzymes; C432966:ITCH protein, human; C492211:CBLB protein, human; D050721:Proto-Oncogene Proteins c-cbl; C520250:RNF128 protein, human; D044767:Ubiquitin-Protein Ligases; C409984:CYLD protein, human; D000074749:Deubiquitinating Enzyme CYLD