title: Mouse models in epigenetics: insights in development and disease.
abstract: Epigenetics is devoted to the study of molecular mechanisms that can modify the structure of the chromatin fiber and, in that way, regulate large-scale patterns of gene transcription. In mammals, most molecular mechanisms that are considered 'epigenetic' have key roles during development and in adult cells and tissues, and have been implicated in a number of human diseases, including cancer. Here, we outline a brief overview on the contribution of the mouse model system to the emergence of epigenetics as a research field on its own.
authors: Instituto de Investigaciones Biomédicas Alberto Sols CSIC-Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain. jespada@iib.uam.es
authors: Jesús
authors: J
authors: Espada
authors: Manel
authors: M
authors: Esteller
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic / Q000235:genetics*; D051379:Mice; D009369:Neoplasms / Q000235:genetics*
keywords: cancer; epigenetic; mouse model