title: Diabetes: Looking back at Look AHEAD--giving lifestyle a chance.
abstract: The Look AHEAD trial did not show that a lifestyle modification programme aimed at weight loss could reduce the incidence of cardiovascular disease events. We attempt to address why this trial was 'negative', and emphasize that further randomized trials of lifestyle modification focusing on the effects of physical activity and exercise are needed.
authors: Jean-Pierre
authors: JP
authors: Després
authors: Paul
authors: P
authors: Poirier
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000628:therapy*; D004032:Diet / Q000009:adverse effects; D057239:Early Termination of Clinical Trials; D015444:Exercise; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D040242:Risk Reduction Behavior; D016896:Treatment Outcome; D015431:Weight Loss