title: Involvement of serotonin receptor mechanisms in the discriminative stimulus effects of ketamine in rats.
abstract: We have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed to investigate the effects of the antipsychotics and 5-HT2 receptor antagonist on the discriminative stimulus effects of ketamine in rats. While sulpiride did not attenuate the discriminative stimulus effects of ketamine, both clozapine and ketanserin attenuated those of ketamine, suggesting that the discriminative stimulus effects of ketamine are mediated by multiple receptors, especially the 5-HT2 receptor, but not the D2 receptor. Furthermore, our findings imply that atypical antipsychotics could be useful for the treatment of psychotomimetic effects induced by ketamine.
authors: Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan.
authors: Kazumi
authors: K
authors: Yoshizawa
authors: Tomohisa
authors: T
authors: Mori
authors: Tamami
authors: T
authors: Ueno
authors: Mizuki
authors: M
authors: Nishiwaki
authors: Masahiro
authors: M
authors: Shibasaki
authors: Norifumi
authors: N
authors: Shimizu
authors: Minoru
authors: M
authors: Narita
authors: Tsutomu
authors: T
authors: Suzuki
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D051381:Rats; D017448:Receptors, Dopamine D2; D044348:Receptors, Serotonin, 5-HT2 / Q000502:physiology*; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000494:pharmacology; D013268:Stimulation, Chemical
chemical_list: D014150:Antipsychotic Agents; D017448:Receptors, Dopamine D2; D044348:Receptors, Serotonin, 5-HT2; D058830:Serotonin 5-HT2 Receptor Antagonists; D007649:Ketamine