title: Second harmonic generation in 3-d uniform arrangement of type I collagen on nonlinear optics microscopy.
abstract: Second harmonic microscopic imaging and spectroscopy technology has become a powerful tool for biomedical studies, especially in fibrosis-related diseases research. And type I collagen is the major risk factors for fibrotic diseases. In this study, model for three-dimensional (3-D) uniform arrangement type I collagen is set up for researching the second harmonic generation (SHG) on nonlinear optics microscopy. Based on this model, we discuss the influence of different length and size collagen in 3-D arrangement type I collagen. Results can guide us to neatly judge the size, length, and molecules density effect on SHG. For practical application, this theoretical approach can lead us to analyze different severity of collagen diseases.
authors: MOE Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China. zhuangzhf@yahoo.com.cn
authors: Z F
authors: ZF
authors: Zhuang
authors: M F
authors: MF
authors: Zhu
authors: Z Y
authors: ZY
authors: Guo
authors: S H
authors: SH
authors: Liu
mesh_terms: D003095:Collagen Diseases / Q000175:diagnosis / Q000473:pathology; D024042:Collagen Type I / Q000737:chemistry*; D008853:Microscopy / Q000379:methods*; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000737:chemistry; D011487:Protein Conformation; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D024042:Collagen Type I; D046912:Multiprotein Complexes