title: Structure and evolutionary origins of the CMG complex.
abstract: The CMG (Cdc45-MCM-GINS) complex is the eukaryotic replicative helicase, the enzyme that unwinds double-stranded DNA at replication forks. All three components of the CMG complex are essential for its function, but only in the case of MCM, the molecular motor that harnesses the energy of ATP hydrolysis to catalyse strand separation, is that function clear. Here, we review current knowledge of the three-dimensional structure of the CMG complex and its components and highlight recent advances in our understanding of its evolutionary origins.
authors: Structural Biology Laboratory, Elettra-Sincrotrone Trieste, Area Science Park, Basovizza, Trieste 34149, Italy. silvia.onesti@elettra.trieste.it
authors: Silvia
authors: S
authors: Onesti
authors: Stuart A
authors: SA
authors: MacNeill
mesh_terms: D018797:Cell Cycle Proteins / Q000737:chemistry* / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000235:genetics; D004247:DNA / Q000235:genetics; D004265:DNA Helicases / Q000737:chemistry* / Q000235:genetics; D004261:DNA Replication / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics; D019143:Evolution, Molecular; D006801:Humans; D026341:Minichromosome Maintenance 1 Protein / Q000737:chemistry* / Q000235:genetics; D011487:Protein Conformation
chemical_list: C113571:CDC45 protein, human; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; C547590:GINS1 protein, human; D026341:Minichromosome Maintenance 1 Protein; D004247:DNA; D004265:DNA Helicases