title: Benzosultines as sulfur dioxide (SO2) donors.
abstract: In order to understand precise biological roles of sulfur dioxide (SO(2)), reliable SO(2) donors, compounds that produce SO(2) under physiological conditions, are necessary. The design and development of 1-phenyl-benzosultine as an efficient SO(2) donor is reported. This compound undergoes cycloreversion to generate SO(2) upon dissolution in aqueous buffer at 37 °C with a yield of 89% and a half-life of 39 min and shows SO(2)-like biological activity in a DNA cleavage assay.
authors: Department of Chemistry, Indian Institute of Science Education and Research Pune, Pune 411 008, Maharashtra, India.
authors: Satish R
authors: SR
authors: Malwal
authors: Mahesh
authors: M
authors: Gudem
authors: Anirban
authors: A
authors: Hazra
authors: Harinath
authors: H
authors: Chakrapani
mesh_terms: D004247:DNA / Q000187:drug effects; D006207:Half-Life; D015394:Molecular Structure; D010075:Oxathiins / Q000737:chemistry*; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013458:Sulfur Dioxide / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010075:Oxathiins; D013457:Sulfur Compounds; D013458:Sulfur Dioxide; D004247:DNA