title: Acute effects of isocaloric meals with different fiber and antioxidant contents on inflammatory markers in healthy individuals.
abstract: Chronic inflammation contributes to the pathophysiology of many chronic diseases. Dietary fibers and antioxidants may exert anti-inflammatory effects. The objective of this study was to determine whether meals with different fibers and antioxidants may elicit a different response in inflammatory markers in healthy volunteers. On 3 separate days, subjects (n = 8) consumed one of three isocaloric meals with different antioxidant (vitamin E, selenium and β-carotene) and fiber content (high, intermediate and low) in a randomized crossover design. Blood samples were collected at different times: 0 min (before the meal), and 30 and 240 min after the meal. Plasma interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, glucose and insulin content were evaluated at each time point. There were no significant differences for any of the parameters at baseline. Furthermore, plasma levels of TNF-α, IL-6 and IL-10 were unchanged at the 30- and 240-min time points whatever meal consumed. Moreover, the cytokine responses to glucose and insulin intake were not significantly different between experimental conditions. In conclusion, isocaloric meals with different fiber, β-carotene, vitamin E and selenium contents do not acutely affect inflammatory markers in healthy young males.
authors: Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, Cidade Universitária, São Paulo, Brazil. dseixas@usp.br
authors: Daniela Fojo Seixas
authors: DF
authors: Chaves
authors: Marina Yazigi
authors: MY
authors: Solis
authors: Paula
authors: P
authors: Gandin
authors: Fabiana Braga
authors: FB
authors: Benatti
authors: Vinícius Lio
authors: VL
authors: Rodrigues
authors: Valéria
authors: V
authors: Paschoal
authors: Andréia
authors: A
authors: Naves
authors: Antonio Herbert
authors: AH
authors: Lancha
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D002908:Chronic Disease; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007328:Insulin / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D062407:Meals; D012643:Selenium / Q000008:administration & dosage; D016037:Single-Blind Method; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage; D055815:Young Adult; D019207:beta Carotene / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D004044:Dietary Proteins; D007328:Insulin; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D019207:beta Carotene; D016753:Interleukin-10; D014810:Vitamin E; D012643:Selenium