title: Long-term outcomes of renal transplants from spousal and living-related and other living-unrelated donors: a single center experience.
abstract: BACKGROUND
  Deceased donor organ shortage has made living donors (LD) major source for renal transplantation (RTx) in India. Spouses represent an important source of allograft. We carried out a retrospective study of spousal RTx vs. other LDRTx to compare long-term results.
  
  
  METHODS
  This retrospective single-center study was undertaken to evaluate demographic, patient survival, graft survival, function vis-à-vis serum creatinine (SCr) and rejection episodes in 1523 living donor renal allograft recipients from 1998 to 2009. It included spouse donors (n=337) (group 1), living related donors (LRD) (n=969) (group 2), and living unrelated donors (LUD) (n=217) (group 3).
  
  
  RESULTS
  Mean recipient age (years +/- SD)) was 41.48 +/- 8.87, 30.49 +/- 10.61, and 37.13 +/- 13.25, respectively for the three groups who were followed for 4.47 +/- 3.03, 4.47 +/- 3.0 and 5.15 +/- 3.28 years respectively. Female donors were 92.6%, 66.4%, and 41%, mean HLA match was 1.15 +/- 0.93, 3 +/- 1.05 and 1.30 +/- 1.08 respectively. One, 5 and 12 year graft survivals among group 1 were 91.39%, 75.49%, and 73.13%; 90.98%, 74.10% and 64.57% in group 2 and 94.92%, 82.86% and 70.31% in group 3. Patient survival for 1, 5 and 12 years were 89.31%, 72.55% and 66.58% in group 1, 93.57%, 82.25% and 72.23% in group 2, and 92.62%, 79.76% and 66.79% in group 3. Acute rejections were noted in 16.6%, 15.8% and 17% respectively.
  
  
  CONCLUSIONS
  In circumstances of organ shortage andunavailability of well developed ABO incompatible transplants, spousal donation is viable option.
authors: Department of Nephrology and Clinical Transplantation, Smt Gulabben Rasiklal Doshi and Smt Kamlaben Mafatlal Mehta Institute of Kidney Diseases and Research Centre.
authors: Vivek B
authors: VB
authors: Kute
authors: Pankaj R
authors: PR
authors: Shah
authors: Aruna V
authors: AV
authors: Vanikar
authors: Manoj R
authors: MR
authors: Gumber
authors: Kamal R
authors: KR
authors: Goplani
authors: Himanshu V
authors: HV
authors: Patel
authors: Bipin C
authors: BC
authors: Munjappa
authors: Hargovind L
authors: HL
authors: Trivedi
authors: Pranjal R
authors: PR
authors: Modi
authors: Veena R
authors: VR
authors: Shah
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood; D005260:Female; D006789:Host vs Graft Reaction; D006801:Humans; D007194:India / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods / Q000401:mortality* / Q000706:statistics & numerical data; D019520:Living Donors / Q000145:classification / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D018454:Spouses / Q000706:statistics & numerical data*; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome; D061349:Unrelated Donors / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D003404:Creatinine