title: Sedation for short hemato-oncologic invasive procedures in children:  comparison of propofol-remifentanil and propofol-fentanyl.
abstract: BACKGROUND
  Short hemato-oncologic procedures are often painful in children, and sedation should be performed outside the operating room.
  
  
  OBJECTIVE
  : The study aims to compare the effects of remifentanil with those of fentanyl administered during short hemato-oncologic interventions in children.
  
  
  METHODS
  A prospective, randomized study was planned for 29 ASA I to III children (aged, 2 to 18 y) to undergo a total of 60 short oncologic interventions. The patients were placed into 2 groups: propofol-remifentanil (group PR) and propofol-fentanyl (group PF). Group PR was first administered propofol (2 mg/kg) and then remifentanil bolus (0.5 μg/kg). Group PF was first administered propofol (2 mg/kg) and then fentanyl bolus (0.5 μg/kg). Systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, respiratory rate, peripheral oxygen saturation, and heart rate were recorded every 3 minutes during the intervention and every 5 minutes after the operation. Postanesthetic recovery scores, eye-opening time to speech, and recovery time were recorded.
  
  
  RESULTS
  Comparison of diastolic arterial pressure in groups at minute 3 of the procedure showed significant difference (P<0.05). Eye-opening to speech (P=0.043) and recovery times (P=0.002) were shorter in group PR.
  
  
  CONCLUSIONS
  During short hemato-oncologic interventions in children, the PR combination is a suitable one for early recovery.
authors: Department of Anesthesiology and Intensive Care, Dokuz Eylül University, İzmir, Turkey.
authors: Icten E
authors: IE
authors: Ince
authors: Leyla
authors: L
authors: Iyilikci
authors: Sebnem
authors: S
authors: Yilmaz
authors: Dilek
authors: D
authors: Güneş
authors: Muhammed
authors: M
authors: Akkuş
authors: Duyguhan
authors: D
authors: Isguven
mesh_terms: D000293:Adolescent; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D016292:Procedural Sedation; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects; D006339:Heart Rate / Q000187:drug effects; D019337:Hematologic Neoplasms / Q000175:diagnosis*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D010880:Piperidines / Q000008:administration & dosage* / Q000009:adverse effects; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D000077208:Remifentanil; D012119:Respiration / Q000187:drug effects
chemical_list: D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D010880:Piperidines; D000077208:Remifentanil; D005283:Fentanyl; D015742:Propofol