title: Dendrimer nanoparticles for ocular drug delivery.
abstract: Eye is a unique organ of perfection and complexity, and is a microcosm of the body in many ways. It represents a great opportunity for nanomedicine, since it is readily accessible-allowing for direct drug/gene delivery to maximize the therapeutic effect and minimize side effects. The development of appropriate delivery systems that can sustain and deliver therapeutics to the target tissues is a key challenge that can be addressed by nanotechnology. Dendrimers are tree-like, nanostructured polymers that have received significant attention as ocular drug delivery systems, due to their well-defined size, tailorable structure, and potentially favorable ocular biodistribution. In this review, we highlight recent developments in dendrimer-based ocular therapies for both anterior and posterior segment diseases.
authors: Department of Ophthalmology, Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors: Siva P
authors: SP
authors: Kambhampati
authors: Rangaramanujam M
authors: RM
authors: Kannan
mesh_terms: D060433:Administration, Ophthalmic; D000818:Animals; D050091:Dendrimers / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D005128:Eye Diseases / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D050091:Dendrimers