title: X-ray triggered release of doxorubicin from nanoparticle drug carriers for cancer therapy.
abstract: Enhanced cellular toxicity was observed using X-ray irradiated nanoparticle drug carriers (NDC) consisting of doxorubicin (DOX) conjugated to DNA strands attached to the surface of gold nanoparticles. Kinetic studies showed that X-rays, acting as a triggering modality, generated reactive oxygen species to break DNA strands and release DOX.
authors: Department of Chemistry, University of California, One Shields Ave., Davis, CA 95616, USA.
authors: Zane B
authors: ZB
authors: Starkewolf
authors: Larissa
authors: L
authors: Miyachi
authors: Joyce
authors: J
authors: Wong
authors: Ting
authors: T
authors: Guo
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D001943:Breast Neoplasms / Q000188:drug therapy; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004247:DNA / Q000378:metabolism; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006046:Gold / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014965:X-Rays
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D017382:Reactive Oxygen Species; D006046:Gold; D004317:Doxorubicin; D004247:DNA