title: Toll-like receptors in hepatitis C infection: implications for pathogenesis and treatment.
abstract: Hepatitis C virus (HCV) infection is a significant global health problem, affecting over 150 million people worldwide. While the critical role of the adaptive immune system in HCV infection is well-established, the importance of the innate immune system in HCV infection has only been recognized in more recent years. Toll-like receptors form the cornerstone of the innate immune response, and there is considerable evidence for their crucial role in hepatitis C infection. This review outlines recent advances made in our understanding of the role of Toll-like receptor function in HCV infection, exploring how HCV manipulates host immunity to evade immune clearance and establish persistent infection despite leading to inflammatory hepatic damage.
authors: Liver Transplant Unit, Austin Hospital, Victoria, Australia. Jess.Howell@austin.org.au
authors: Jessica
authors: J
authors: Howell
authors: Peter
authors: P
authors: Angus
authors: Paul
authors: P
authors: Gow
authors: Kumar
authors: K
authors: Visvanathan
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D006526:Hepatitis C / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D018836:Inflammation Mediators / Q000378:metabolism; D008024:Ligands; D008099:Liver / Q000276:immunology*; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000737:chemistry / Q000276:immunology* / Q000502:physiology
chemical_list: D018925:Chemokines; D016207:Cytokines; D018836:Inflammation Mediators; D008024:Ligands; D051193:Toll-Like Receptors