title: Protein corona significantly reduces active targeting yield.
abstract: When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.
authors: Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
authors: Vahid
authors: V
authors: Mirshafiee
authors: Morteza
authors: M
authors: Mahmoudi
authors: Kaiyan
authors: K
authors: Lou
authors: Jianjun
authors: J
authors: Cheng
authors: Mary L
authors: ML
authors: Kraft
mesh_terms: D008055:Lipids / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry; D013499:Surface Properties
chemical_list: D008055:Lipids; D011506:Proteins; D012825:Silicon