title: [The influence of afobazole on biochemical and histo-patho-morphological parameters of endothelial function at experimental diabetes mellitis in rats].
abstract: Oxidizing stress in rats with experimental diabetes mellitis is accompanied by endothelial dysfunction develops. Its biochemical markers are the increase of concentration of blood MDA, the impairments of cell antioxidant depence and a decrease in concentration of total metabolites of NO and expression of endothelial NO-synthetase (e-NOS). Biochemical changes are considered with histopathomorphologic impairments of aortic endothelium. Treatment with afobazole suppressed free-radical oxidation, increased activity of SOD and concentration of total metabolites of NO and a level of eNOS expression and also restored of a histologic pattern of aortic endothelium due to activation of nucleocytoplasmic regenerative processes.
authors: S G
authors: SG
authors: Dzugkoev
authors: K M
authors: KM
authors: Kozyrev
authors: N G
authors: NG
authors: gumanova
authors: F S
authors: FS
authors: Dzugkoeva
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000473:pathology; D001562:Benzimidazoles / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D005609:Free Radicals / Q000097:blood*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D009025:Morpholines / Q000494:pharmacology*; D009569:Nitric Oxide / Q000097:blood*; D052250:Nitric Oxide Synthase Type III / Q000096:biosynthesis; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D015415:Biomarkers; D005609:Free Radicals; D009025:Morpholines; D009569:Nitric Oxide; D008315:Malondialdehyde; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat