title: Assessment between Dopamine Receptor D2 (DRD2) Polymorphisms and Schizophrenia in Korean Population.
abstract: OBJECTIVE
  The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) of dopamine receptor D2 (DRD2) are associated with schizophrenia in Korean population.
  
  
  METHODS
  Four SNPs (rs4648317, rs7131056, rs4936270, and rs1076562) of DRD2 were selected and genotyped by direct sequencing in 197 schizophrenia patients and 370 control subjects. SNPAnalyzer, SNPStats, and Haploview version 4.2 programs were performed to analyze the genetic data. Multiple logistic regression models (codominant1, codominant2, dominant, recessive, overdominant, and log-additive) were used to evaluate the odds ratios (ORs), 95% confidence intervals (CIs), and p values. For multiple testing, p values (p(c)) were re-evaluated by Bonferroni's correction.
  
  
  RESULTS
  The genotype frequency of DRD2 rs4936270 SNP was associated with the development of schizophrenia (p=0.0007, OR=1.71, 95% CI=1.16-2.52 in the codominant1 model; p=0.011, OR=1.63, 95% CI=1.12-2.37 in the dominant model; p=0.035, OR=1.41, 95% CI=1.03-1.95 in the log-additive model). The allele frequency of rs4936270 was also associated with the development of schizophrenia (p=0.024, OR=1.45, 95% CI=1.05-1.98). After Bonferroni's correction, the genotype distribution of rs4936270 was still related to the development of schizophrenia (p(c)=0.0028 in the codominant1 model; p(c)=0.044 in the dominant model). A linkage disequilibrium block consisted of rs4648317, rs7131056, and rs4936270. The CAT haplotype frequency was different between schizophrenia and controls (p=0.039).
  
  
  CONCLUSIONS
  These results suggest that DRD2 SNPs may be associated with the development of schizophrenia in Korean population.
authors: Department of Neuropsychiatry, Kyung Hee University, School of Medicine, Seoul, Korea.
authors: Ah Rang
authors: AR
authors: Cho
authors: Sang Min
authors: SM
authors: Lee
authors: Won Sub
authors: WS
authors: Kang
authors: Su Kang
authors: SK
authors: Kim
authors: Joo-Ho
authors: JH
authors: Chung
keywords: Dopamine receptor D2; Haplotypes; Schizophrenia; Single nucleotide polymorphism