title: Th1- and Th2-like subsets of innate lymphoid cells.
abstract: Innate lymphoid cells (ILCs) constitute a family of effectors in innate immunity and regulators of tissue remodeling that have a cytokine and transcription factor expression pattern that parallels that of the T-helper (Th) cell family. Here, we discuss how ILCs can be categorized and summarize the current knowledge of Th1- and Th2-like ILCs with regard to the molecular mechanisms of development, effector functions, and their interplay with other cell types.
authors: Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.
authors: Jochem
authors: J
authors: Bernink
authors: Jenny
authors: J
authors: Mjösberg
authors: Hergen
authors: H
authors: Spits
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage / Q000276:immunology*; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D053699:Interleukin-7 Receptor alpha Subunit / Q000235:genetics / Q000276:immunology; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology; D008214:Lymphocytes / Q000145:classification / Q000166:cytology / Q000276:immunology*; D051379:Mice; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology
chemical_list: D016207:Cytokines; D053699:Interleukin-7 Receptor alpha Subunit; D014157:Transcription Factors