title: Plasma concentration of soluble intercellular adhesion molecule-1 (sICAM-1) is elevated in type 2 diabetic patients, and sICAM-1 synthesis is associated with leptin-induced activation of the mitogen-activated protein kinase (MAPK) pathway.
abstract: The intercellular adhesion molecule-1 (ICAM-1) and leptin are important inflammatory biomarkers. We investigated whether plasma-soluble ICAM-1 levels were related to the diabetic nephropathy and systemic inflammation. One hundred forty-seven type 2 diabetic patients and 46 healthy control subjects were studied. Plasma sICAM-1 concentrations were significantly higher in the diabetic groups than controls and increased significantly as diabetic nephropathy advanced. Plasma sICAM-1 levels were positively correlated with body mass index, fasting and postprandial blood glucose, urinary albumin excretion, and negatively correlated with creatinine clearance. Multiple regression analysis showed that plasma leptin levels were associated with a significant increase in plasma sICAM-1 levels. In cultured HUVECs, leptin increased ICAM-1 production in a dose-dependent manner, and this stimulating effect of leptin on ICAM-1 expression was reversed by MEK inhibitor, PD98059. Overall, these findings suggest that activation of leptin synthesis in a diabetic environment promotes ICAM-1 activation via mitogen-activated protein kinase pathway in type 2 diabetic patients.
authors: Department of Internal Medicine, Korea University Ansan Hospital, 516 Kojan-Dong, Ansan City, Kyungki-Do 425-020, South Korea.
authors: Jin Joo
authors: JJ
authors: Cha
authors: Young Youl
authors: YY
authors: Hyun
authors: Yi Hwa
authors: YH
authors: Jee
authors: Mi Jin
authors: MJ
authors: Lee
authors: Kum Hyun
authors: KH
authors: Han
authors: Young Sun
authors: YS
authors: Kang
authors: Sang Youb
authors: SY
authors: Han
authors: Dae Ryong
authors: DR
authors: Cha
mesh_terms: D000419:Albuminuria; D001786:Blood Glucose; D015992:Body Mass Index; D002478:Cells, Cultured; D003404:Creatinine / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000201:enzymology*; D003928:Diabetic Nephropathies / Q000097:blood; D004789:Enzyme Activation; D005215:Fasting; D005260:Female; D005419:Flavonoids / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000378:metabolism*; D020738:Leptin / Q000097:blood / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D008297:Male; D008875:Middle Aged; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D047428:Protein Kinase Inhibitors
chemical_list: D001786:Blood Glucose; D005419:Flavonoids; D020738:Leptin; D047428:Protein Kinase Inhibitors; D018799:Intercellular Adhesion Molecule-1; D003404:Creatinine; D020928:Mitogen-Activated Protein Kinases; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one