title: Growth factor receptors define cancer hierarchies.
abstract: Normal and neoplastic tissues display cellular hierarchies that integrate extracellular cues to maintain tissue function through bidirectional signals mediated via cell surface proteins. Two papers in Cancer Cell, one in this issue (Day and colleagues) and one in a recent issue (Binda and colleagues), describe how Eph receptor tyrosine kinases critically define and regulate the growth of cancer stem cells.
authors: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors: Monica
authors: M
authors: Venere
authors: Justin D
authors: JD
authors: Lathia
authors: Jeremy N
authors: JN
authors: Rich