title: Increasing effects of S-methyl-L-cysteine on the extracellular D-serine concentrations in the rat medial frontal cortex.
abstract: In an in vivo dialysis experiment, the intra-medial frontal cortex infusion of a system A and Asc-1 transporter inhibitor, S-methyl-L-cysteine, caused a concentration-dependent increase in the dialysate contents of an endogenous coagonist for the N-methyl-D-aspartate (NMDA) type glutamate receptor, D-serine, in the cortical portion. These results suggest that these neutral amino acid transporters could control the extracellular D-serine signaling in the brain and be a target for the development of a novel threapy for neuropsychiatric disorders with an NMDA receptor dysfunction.
authors: Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
authors: Sayuri
authors: S
authors: Ishiwata
authors: Shigehiro
authors: S
authors: Ogata
authors: Asami
authors: A
authors: Umino
authors: Hirohisa
authors: H
authors: Shiraku
authors: Yoshitaka
authors: Y
authors: Ohashi
authors: Yasushi
authors: Y
authors: Kajii
authors: Toru
authors: T
authors: Nishikawa
mesh_terms: D026921:Amino Acid Transport Systems, Neutral / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D003545:Cysteine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D045604:Extracellular Fluid / Q000378:metabolism; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism*; D057967:Infusions, Intraventricular; D008297:Male; D017551:Microdialysis / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012694:Serine / Q000737:chemistry*
chemical_list: D026921:Amino Acid Transport Systems, Neutral; D000596:Amino Acids; D012694:Serine; C008425:S-methylcysteine; D003545:Cysteine