title: [Dapsone-induced decrease in the HbA(1c) level may cause artefacts in diabetic control].
abstract: Glycated haemoglobin (HbA(1c)) level is used to monitor glycaemic control in diabetic patients, and has recently been included as a diagnostic factor for type 2 diabetes mellitus (DM). A 50-year-old male with well-controlled type 1 DM, Mb Addison and coeliac disease was diagnosed with dermatitis herpetiformis and treated with dapsone. Subsequently, the patient presented a pronounced drop in HbA(1c) levels without changes in blood glucose levels. S-fructosamine values were in agreement with the previous stable HbA(1c) values. Blood analyses showed inappropriately low HbA(1c) values due to mild haemolysis and shortening of erythrocyte lifetime without anaemia.
authors: Medicinsk Endokrinologisk Afdeling, Aarhus Universitetshospital, Denmark. siv@lajlev.dk
authors: Siv Elisabeth
authors: SE
authors: Lajlev
authors: Søren Andreas
authors: SA
authors: Ladefoged
authors: Kjeld
authors: K
authors: Hermansen
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003874:Dermatitis Herpetiformis / Q000188:drug therapy; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000890:Anti-Infective Agents; D003622:Dapsone; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human