title: [Serrated polyps and serrated polyposis syndrome].
abstract: Serrated polyps of the colorectum are a heterogeneous group of lesions with potential malignant transformation through the «serrated pathway» of carcinogenesis. The discovery of these lesions has been a paradigm shift in the concept of the adenoma-carcinoma sequence, so that up to 30% of tumors develop through this pathway. The main factors associated with an increased risk of malignancy in serrated polyps are size≥10mm, multiplicity, sessile serrated adenoma histology, presence of associated dysplasia and proximal location. Current evidence indicates that these lesions should be resected completely, and the patient requires an endoscopic surveillance program. Serrated polyposis syndrome is a clinicopathological entity characterized by multiple and/or large serrated polyps with an increased risk of developing colorectal cancer. These patients and their families, require multidisciplinary assessment in specialized high risk colorectal cancer units.
authors: Servicio de Gastroenterología, Hospital Clínic, Barcelona, España.
authors: Sabela
authors: S
authors: Carballal
authors: Leticia
authors: L
authors: Moreira
authors: Francesc
authors: F
authors: Balaguer
mesh_terms: D003111:Colonic Polyps / Q000150:complications* / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000209:etiology*; D006801:Humans; D044483:Intestinal Polyposis / Q000150:complications* / Q000473:pathology*; D011230:Precancerous Conditions / Q000150:complications / Q000473:pathology; D013577:Syndrome