title: Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia.
abstract: This paper reports that bioassay-guided fractionations of EtOH extract of Momordica charantia fruits led to the isolation of 15 cucurbitane-type triterpene glycosides including 4 new compounds, kuguaosides A-D (1-4), along with 11 known ones, charantoside A (5), momordicosides I (6), F1 (7), F2 (8), K (9), L (10), and U (11), goyaglycosides-b (12) and -d (13), 7β,25-dihydroxycucurbita-5,23(E)-dien-19-al 3-O-β-d-allopyranoside (14), and 25-hydroxy-5β,19-epoxycucurbita-6,23-dien-19-on-3β-ol 3-O-β-d-glucopyranoside (15). Their structures were elucidated on the basis of spectroscopic analyses and chemical methods. This study also established the HPLC-ELSD fingerprinting profile of an antiproliferative fraction of which 11 main peaks were identified. Biological evaluation showed that several isolated cucurbitane-type triterpene glycosides had antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines. In addition, compound 14 showed potent hypoglycemic activities by glucose uptake assay.
authors: Divison of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
authors: Ping-Chun
authors: PC
authors: Hsiao
authors: Chia-Ching
authors: CC
authors: Liaw
authors: Syh-Yuan
authors: SY
authors: Hwang
authors: Hui-Ling
authors: HL
authors: Cheng
authors: Li-Jie
authors: LJ
authors: Zhang
authors: Chien-Chang
authors: CC
authors: Shen
authors: Feng-Lin
authors: FL
authors: Hsu
authors: Yao-Haur
authors: YH
authors: Kuo
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005638:Fruit / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D029777:Momordica charantia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014315:Triterpenes; C514277:cucurbitane