title: Effect of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease.
abstract: OBJECTIVE
  To observe the effects of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease.
  
  
  METHODS
  Capitalized 101 patients with coronary heart disease were randomly divided into a treatment group (n = 45) treated with Liandouqingmai Recipe and a standard treatment group (control group, n = 56). A normal group of 16 healthy persons was additionally set up. Changes in ET-1 and NO levels were measured and Seatle Angina Questionnaire (SAQ) was adopted in studying life quality before and after treatment for two weeks. The data were analyzed with SPSS 16.0 statistic software.
  
  
  RESULTS
  The average level of ET-1 in the normal group was lower and NO higher than that of patients with coronary heart disease. There was no significant difference in the average level of ET-1 and NO and in the scores of SAQ [physical limitation (PL), apngina stability (AS), apngina frequency (AF), treatment satisfaction (TS) and disease perception (DP)] between the two groups before treatment (P > 0.05). But after treatment, the scores of SAQ (PL, AS, AF, TS, DP) and NO level were higher than those in the control group, and ET-1 average level in the treatment group was lower than that in the control group. The negative relations between PL and ET-1 and between AF and ET-1 were found in this study.
  
  
  CONCLUSIONS
  Liandouqingmai Recipe can raise scores of SAQ and NO level and decline ET level in patients with coronary heart disease on the basis of convertional standard treatment, thus improving vascular endothelial function and life quality. Life quality is related to vascular endothelial function.
authors: First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China.
authors: Hongjun
authors: H
authors: Zhu
authors: Shu
authors: S
authors: Lu
authors: Wei
authors: W
authors: Su
authors: Shaoyu
authors: S
authors: Gong
authors: Zhibin
authors: Z
authors: Zhang
authors: Ping
authors: P
authors: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D004365:Drugs, Chinese Herbal; D019332:Endothelin-1