title: Anti-inflammatory and draining effect of the Deep Oscillation® device tested clinically and on a model of human skin maintained in survival condition.
abstract: The objective of this study was to evaluate the anti-inflammatory, toning and draining effect of the Deep Oscillation® device. The Deep Oscillation® device uses the forces of pulsed electrostatic attraction and friction to provoke oscillations that act on the epidermis, dermis, and sub-cutaneous layers of tissue. An ex-vivo study was first completed by using a model of skin maintained in survival condition. The draining and anti-inflammatory effects of the device were determined by pro-inflammatory cytokine assay and by histological analysis of capillary dilation. The analgesic effectiveness of the Deep Oscillation® was then evaluated by immunohistochemical analysis of TRPV1. To corroborate this data, a clinical study was conducted by selecting 20 subjects with periorbital bags or dark circles to undergo treatment with the device. Evaluations included photography, dermatological scores as well as ultrasound analysis. Using an ex-vivo model of human skin maintained in survival condition, the Deep Oscillation® device was effective in reducing inflammation with a significant reduction of dilated capillaries and IL8, while lowering sensory receptor levels. Clinically, the device was successful in reducing both dark circles and bags by an average of 40%.
authors: GREDECO Research Company, 121 rue de la Pompe, 75116 Paris, France. gredeco@orange.fr
authors: Sylvie
authors: S
authors: Boisnic
authors: Marie-Christine
authors: MC
authors: Branchet
mesh_terms: D000328:Adult; D000698:Analgesia; D002196:Capillaries / Q000502:physiology; D004487:Edema / Q000628:therapy*; D004599:Electric Stimulation Therapy; D005148:Facial Dermatoses / Q000378:metabolism* / Q000628:therapy*; D005260:Female; D017276:Friction; D006801:Humans; D066298:In Vitro Techniques; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D012879:Skin Physiological Phenomena; D055672:Static Electricity; D050916:TRPV Cation Channels / Q000378:metabolism
chemical_list: D016209:Interleukin-8; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human
keywords: Deep Oscillation; inflammation; surviving skin; undereye bags and circles