title: Reduction of abdominal fat accumulation in rats by 8-week ingestion of a newly developed sweetener made from high fructose corn syrup.
abstract: Many studies have shown that ingestion of high-fructose corn syrup (HFCS) may cause an increase in body weight and abdominal fat. We recently developed a new sweetener containing rare sugars (rare sugar syrup; RSS) by slight isomerization of HFCS. Here, the functional effects of RSS on body weight and abdominal fat, and biochemical parameters in Wistar rats were examined. Rats (n=30) were randomly divided into three groups and maintained for 8-weeks on starch, starch+HFCS (50:50), and starch+RSS (50:50) diets. Rats in the Starch and HFCS groups gained significantly more body weight and abdominal fat than the RSS group. Fasting serum insulin in the RSS group was significantly lower than in the Starch and HFCS groups, although serum glucose in the HFCS and RSS groups was significantly lower than that in the Starch group. Thus, the substitution of HFCS with RSS prevents obesity induced by the consumption of HFCS.
authors: Research Institute, Matsutani Chemical Industry Co., Ltd., 5-3, Kita-Itami, Itami, Hyogo 664-8508, Japan. tetsuo-iida@matsutani.co.jp
authors: Tetsuo
authors: T
authors: Iida
authors: Takako
authors: T
authors: Yamada
authors: Noriko
authors: N
authors: Hayashi
authors: Kazuhiro
authors: K
authors: Okuma
authors: Ken
authors: K
authors: Izumori
authors: Reika
authors: R
authors: Ishii
authors: Tatsuhiro
authors: T
authors: Matsuo
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D015536:Down-Regulation; D005632:Fructose / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013549:Sweetening Agents / Q000032:analysis / Q000378:metabolism*; D003313:Zea mays / Q000737:chemistry*
chemical_list: D007328:Insulin; D013549:Sweetening Agents; D005632:Fructose; D005947:Glucose