title: Genetic variability of HEV isolates: inconsistencies of current classification.
abstract: Many HEV and HEV-like sequences have been reported during the last years, including isolates which may represent a number of potential new genera, new genotypes or new subtypes within the family Hepeviridae. Using the most common classification system, difficulties in the establishment of subtypes have been reported. Moreover the relevance of subtype classification for epidemiology can be questioned. In this study we have performed phylogenetic analyses based on whole capsid gene and complete HEV genomic sequences in order to evaluate the current classification of HEV at genotype and subtype levels. The results of our analyses modify the current taxonomy of genotype 3 and refine the established system for typing of HEV. In addition we suggest a classification for hepeviruses recently isolated from bats, ferrets, rats and wild boar.
authors: Institut für Virologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Giessen, BFS, Schubertstrasse 81, 35392 Giessen, Germany. edmilsonz@yahoo.com.br
authors: Edmilson F
authors: EF
authors: Oliveira-Filho
authors: Matthias
authors: M
authors: König
authors: Heinz-Jürgen
authors: HJ
authors: Thiel
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000235:genetics; D002685:Chiroptera / Q000821:virology; D014644:Genetic Variation; D005838:Genotype; D016751:Hepatitis E / Q000662:veterinary* / Q000821:virology; D016752:Hepatitis E virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D010802:Phylogeny; D051381:Rats; D013552:Swine / Q000821:virology
chemical_list: D036022:Capsid Proteins