title: Modulation of physical properties of reverse hexagonal mesophases: a dielectric spectroscopy study.
abstract: The structural, dynamic, and kinetic aspects of the HII systems based on glycerol monooleate (GMO), phosphatidylcholine (PC), triacylglycerol (TAG), and water were investigated by dielectric spectroscopy in a frequency range of 10(-2)-10(6) Hz, and a temperature range of 290-320 K. Three distinct processes as well as a temperature-activated dc conductivity were detected and examined. These were assigned to the reorientation of the GMO polar heads, the tangential movement of counterions at the interface, the transport of TAGs through the lipids tails, and the ion mobility within the water cylinders. Upon addition of PC, the critical temperature (T0) of the dehydration of the GMO headgroups increased. The optimal concentration found for structural stabilization of the HII mesophase was 10 wt% PC, since it imparted the strongest bonding at the interfacial layer and increased the association between the lipid tails. Within the HII cluster, TAG percolated and shifted between the hexagonal rods themselves. The present study demonstrated the benefit of controlling the critical temperature of the HII mesophase partial dehydration and softening, as well as the percolation of TAGs. These factors influence the diffusion mode of embedded drugs in the physiological temperature range.
authors: The Ratner Chair in Chemistry, Casali Institute of Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
authors: Tehila
authors: T
authors: Mishraki
authors: Paul
authors: P
authors: Ben Ishai
authors: Dmitry
authors: D
authors: Babukh
authors: Abraham
authors: A
authors: Aserin
authors: Yuri
authors: Y
authors: Feldman
authors: Nissim
authors: N
authors: Garti
mesh_terms: D002210:Caprylates / Q000737:chemistry; D058266:Dielectric Spectroscopy; D016503:Drug Delivery Systems; D005989:Glycerides / Q000737:chemistry*; D050866:Liquid Crystals / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*; D055585:Physical Phenomena; D013696:Temperature; D014280:Triglycerides / Q000737:chemistry*
chemical_list: D002210:Caprylates; D005989:Glycerides; D010713:Phosphatidylcholines; D014280:Triglycerides; C005953:monoolein