title: Control of HIV infection: escape from the shadow of Blimp-1.
abstract: Prior murine studies have demonstrated the pivotal role that Blimp-1 has in the exhausted phenotype of T lymphocytes in chronic viral infection. In this issue of the European Journal of Immunology, Seddiki et al. [Eur. J. Immunol. 2013. 43: 510-520] demonstrate the applicability of this research to HIV infection. The authors do so by demonstrating differences in Blimp-1 expression between T lymphocytes isolated from patients with chronic active HIV versus those from long-term nonprogressors and showing that this is matched by differences in the cells' capacity to produce IL-2 and the level of expression of the inhibitory receptor PD-1. The data presented here suggest that this may relate to differential regulation of Blimp-1 by the micro RNA, mIR-9. These findings complement current murine work and fit squarely within the research priorities, as outlined by the International AIDS Society, for determining a cure for AIDS.
authors: Cambridge Centre for Lung Infection, Papworth Hospital NHS Foundation Trust, Cambridge, UK.
authors: James E
authors: JE
authors: Thaventhiran
authors: Douglas T
authors: DT
authors: Fearon
mesh_terms: D000818:Animals; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D006801:Humans; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000821:virology
chemical_list: D012097:Repressor Proteins; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1