title: Is a pacific coexistence between virus and host the unexploited path that may lead to an HIV functional cure?
abstract: The SupT1 cell line supports optimal HIV-1 replication, and prolonged in vitro replication in SupT1 cells renders the virus significantly less virulent. This raises the question of whether the infusion of SupT1 cells could be used as a cell-based therapy to induce a pacific coexistence between the HIV virus and its human host. In a recent study, I investigated this potential therapeutic strategy in vitro. The results suggested that this approach should be further explored in HIV-susceptible animal models. Such studies may lead to the development of a functional cure for HIV infection.
authors: Immunobiology of HIV Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, via Stamira D'Ancona 20, 20127 Milan, Italy. jonathan.fior82@gmail.com
authors: Jonathan
authors: J
authors: Fior
mesh_terms: D002460:Cell Line; D015658:HIV Infections / Q000628:therapy / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D014779:Virus Replication