title: A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals.
abstract: The first multicomponent catalytic asymmetric synthesis of spiroacetals has been described. Hybrid molecules comprising a spiroacetal scaffold (a natural-product inspired scaffold) and an α-amino acid motif (a privileged fragment) are easily available through a gold phosphate-catalysed one-pot three component coupling reaction of alkynols, anilines and glyoxylic acid.
authors: Instituto Universitario de Química Organometálica Enrique Moles, Universidad de Oviedo, Julián Clavería 8, 33006-Oviedo, Spain.
authors: Lara
authors: L
authors: Cala
authors: Abraham
authors: A
authors: Mendoza
authors: Francisco J
authors: FJ
authors: Fañanás
authors: Félix
authors: F
authors: Rodríguez
mesh_terms: D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000080:Acetals; D010710:Phosphates; D013141:Spiro Compounds; D006046:Gold