title: A genome-wide association study of recipient genotype and medium-term kidney allograft function.
abstract: BACKGROUND
  We examined, through genome-wide association studies (GWAS), the correlation between recipient genetic variation and renal function at five yr.
  
  
  METHODS
  Our cohort contained 326 Irish, first time, kidney-only, deceased donor, transplant recipients on calcineurin inhibitors (263 had a functioning graft at five yr) between 1993 and 2002. Outcomes were creatinine at five yr and long-term graft function.
  
  
  RESULTS
  Two variants were identified showing borderline genome-wide significance - one on chromosome 18 (p = 4.048e-08, rs6565887) and another on chromosome 14 (p = 7.631e-08, rs3811321). Individually, the two SNPs explained up to 8.8% and 11.29% of five-yr creatinine variance, respectively, while together they explained up to 17.4% of trait variance. Both variants were predictors of long-term allograft function (p = 0.004, 70% vs 30% survival at 10 yr). The chromosome 14 variant is located in the intergenic region of the T-Cell Receptor Alpha locus.
  
  
  CONCLUSIONS
  Using a genome-wide approach, we have identified two associations with five-yr creatinine levels in renal transplant recipients treated with calcineurin inhibitors. Independent replication is now warranted to clarify the clinical significance of these results.
authors: Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland.
authors: Robert P
authors: RP
authors: O'Brien
authors: Paul J
authors: PJ
authors: Phelan
authors: Judith
authors: J
authors: Conroy
authors: Patrick
authors: P
authors: O'Kelly
authors: Andrew
authors: A
authors: Green
authors: Mary
authors: M
authors: Keogan
authors: Derek
authors: D
authors: O'Neill
authors: Susan
authors: S
authors: Jennings
authors: Carol
authors: C
authors: Traynor
authors: Jillian
authors: J
authors: Casey
authors: Mark
authors: M
authors: McCormack
authors: Ronan
authors: R
authors: Conroy
authors: Anthony
authors: A
authors: Chubb
authors: Sean
authors: S
authors: Ennis
authors: Denis C
authors: DC
authors: Shields
authors: Gianpiero L
authors: GL
authors: Cavalleri
authors: Peter J
authors: PJ
authors: Conlon
mesh_terms: D000328:Adult; D064591:Allografts; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D055106:Genome-Wide Association Study; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics* / Q000401:mortality; D006085:Graft Survival / Q000235:genetics*; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D011379:Prognosis; D015996:Survival Rate
chemical_list: D003404:Creatinine