title: No viral evolution in the lymph nodes of simian immunodeficiency virus-infected rhesus macaques during combined antiretroviral therapy.
abstract: To elucidate the mode of viral persistence in primate lentivirus-infected individuals during combination antiretroviral therapy (cART), four simian immunodeficiency virus 239-infected monkeys were treated with cART for 1 year. The viral env genes prepared from total RNA extracted from the mesenteric lymph nodes collected at the completion of therapy were assessed by single genome amplification. Analyses of nucleotide substitutions and phylogeny revealed no viral evolution during cART.
authors: Laboratory of Primate Model, Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto, Japan.
authors: Megu
authors: M
authors: Oue
authors: Saori
authors: S
authors: Sakabe
authors: Mariko
authors: M
authors: Horiike
authors: Mika
authors: M
authors: Yasui
authors: Tomoyuki
authors: T
authors: Miura
authors: Tatsuhiko
authors: T
authors: Igarashi
mesh_terms: D000818:Animals; D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active; D019143:Evolution, Molecular; D015686:Gene Products, env / Q000235:genetics; D008198:Lymph Nodes / Q000821:virology*; D008253:Macaca mulatta; D010802:Phylogeny; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D044966:Anti-Retroviral Agents; D015686:Gene Products, env