title: Evaluation of radiation-induced myocardial damage using iodine-123 β-methyl-iodophenyl pentadecanoic acid scintigraphy.
abstract: We evaluated radiation-induced myocardial damage using iodine-123 β-methyl-iodophenyl pentadecanoic acid (I-123 BMIPP) scintigraphy. Between May 2010 and April 2011 we performed I-123 BMIPP scintigraphy for patients who had maintained complete response to curative radiotherapy (RT) for esophageal cancer for more than six months. We compared the area of the myocardium in the RT fields with that of reduced I-123 BMIPP uptake using a 15-segment model that is based on axial computed tomography (CT) images. We classified the segments into three categories: segments receiving 40 Gy (Segment 40 Gy), segments receiving 60 Gy (Segment 60 Gy) and segments out of the radiation fields (Segment 0 Gy). A segment with reduced uptake in the RT fields was defined as positive. A total of 510 segments in 34 patients were used for analysis. The median interval from completion of RT to I-123 BMIPP scintigraphy was 22 months (range, 6-103 months). The numbers of Segment 0 Gy, Segment 40 Gy and Segment 60 Gy were 324, 133 and 53, respectively. Reduced uptake was detected in 42.9% (57/133) of Segment 40 Gy, 67.9% (36/53) of Segment 60 Gy and 13.3% (43/324) of Segment 0 Gy. The odds ratios of 40 Gy and 60 Gy compared with regions out of the RT fields were 5.2 (95% confidence interval [CI]: 3.7-7.4) and 15.4 (95% CI: 6.9-34.6), respectively. Reduced myocardial I-123 BMIPP uptake in RT fields, suggesting RT-induced myocardial damage, was frequently observed. I-123 BMIPP myocardial scintigraphy may be useful for identifying RT-induced myocardial damage.
authors: Department of Radiation Oncology, Tohoku University School of Medicine, Seiryou-machi 1-1, Aobaku, Sendai 980-8574, Japan.
authors: Rei
authors: R
authors: Umezawa
authors: Kei
authors: K
authors: Takase
authors: Keiichi
authors: K
authors: Jingu
authors: Kentaro
authors: K
authors: Takanami
authors: Hideki
authors: H
authors: Ota
authors: Tomohiro
authors: T
authors: Kaneta
authors: Ken
authors: K
authors: Takeda
authors: Haruo
authors: H
authors: Matsushita
authors: Hisanori
authors: H
authors: Ariga
authors: Shoki
authors: S
authors: Takahashi
authors: Shogo
authors: S
authors: Yamada
mesh_terms: D000368:Aged; D004938:Esophageal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D005227:Fatty Acids; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000528:radiation effects; D006331:Heart Diseases / Q000000981:diagnostic imaging* / Q000209:etiology*; D006801:Humans; D007462:Iodobenzenes; D008297:Male; D011832:Radiation Injuries / Q000000981:diagnostic imaging* / Q000209:etiology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D005227:Fatty Acids; D007462:Iodobenzenes; D019275:Radiopharmaceuticals; C049338:iodofiltic acid
keywords: I-123 BMIPP; esophageal cancer; heart; radiation-induced myocardial damage; radiotherapy