title: Late-onset Leber hereditary optic neuropathy.
abstract: BACKGROUND
  While Leber hereditary optic neuropathy typically causes bilateral visual loss in the second through fourth decades, we highlight visual loss from Leber hereditary optic neuropathy in older patients to characterize the clinical features of this cohort.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Patients seen between January 2003 and July 2012 at Baylor College of Medicine and between April 2010 and July 2012 at The Methodist Hospital in Houston, Texas.
  
  
  METHODS
  Patients with visual loss from genetically confirmed Leber hereditary optic neuropathy were identified via retrospective chart review.
  
  
  METHODS
  Clinical courses of patients.
  
  
  RESULTS
  Five patients with visual loss from genetically confirmed Leber hereditary optic neuropathy were greater than 60 years of age at the time of visual loss (range 62-70 years, mean 66.4 ± 3.0).
  
  
  CONCLUSIONS
  This series reinforces the importance of including Leber hereditary optic neuropathy in the differential diagnosis of patients of any age with optic neuropathy.
authors: The University of Texas Medical School at Houston, Houston, Texas, USA.
authors: Margaret L
authors: ML
authors: Pfeiffer
authors: Nafiseh
authors: N
authors: Hashemi
authors: Rod
authors: R
authors: Foroozan
authors: Andrew G
authors: AG
authors: Lee
mesh_terms: D000368:Aged; D004272:DNA, Mitochondrial / Q000235:genetics; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D029242:Optic Atrophy, Hereditary, Leber / Q000175:diagnosis* / Q000235:genetics; D017354:Point Mutation; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000175:diagnosis* / Q000235:genetics; D014792:Visual Acuity / Q000502:physiology
chemical_list: D004272:DNA, Mitochondrial
keywords: Leber hereditary optic neuropathy; neuro-ophthalmic disease; optic neuropathy mitochondrial DNA