title: Spectroscopic evaluation for VO(II), Ni(II), Pd(II) and Cu(II) complexes derived from thiosemicarbazide: a special emphasis on EPR study and DNA cleavage.
abstract: Some thiosemicarbazide complexes were prepared and deliberately investigated by all allowed tools. The ligand coordinates as a mono negative bidentate towards VO(II) and Ni(II) as well as a neutral bidentate towards Pd(II) and Cu(II) ions. Electronic spectral data beside the magnetic measurements facilitate the structural geometry proposal. EPR spectra of Cu(II) and VO(II) complexes were recorded in their solid state. Spin Hamiltonian parameters and molecular orbital coefficient for Cu(II) and VO(II) complexes were calculated and supporting the octahedral geometry of Cu(II) complex and a square pyramidal for VO(II) one. The biological activity investigation was studied by the use of all prepared compounds. The VO(II) and Cu(II) complexes display the susceptible biotoxicity against a gram-positive bacterium. Also, Cu(II) complex displays the same toxicity against gram-negative bacteria used. The effect of all compounds on DNA were photographed. A successive degradation for the DNA target was observed with Pd(II) and Ni(II) complexes beside their original ligand.
authors: Chemistry Department, Faculty of Science, Mansoura University, Egypt. n_elmetwaly00@yahoo.com
authors: Nashwa M
authors: NM
authors: El-Metwally
authors: Gamil A A
authors: GA
authors: Al-Hazmi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry; D053837:DNA Cleavage / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry* / Q000494:pharmacology; D010087:Oxides / Q000737:chemistry* / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry* / Q000494:pharmacology; D012663:Semicarbazides / Q000737:chemistry* / Q000494:pharmacology; D017968:Vanadium Compounds / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D010087:Oxides; D012663:Semicarbazides; D017968:Vanadium Compounds; C581824:vanadium dioxide; D010165:Palladium; C005151:thiosemicarbazide; D003300:Copper; D009532:Nickel; D004247:DNA