title: Zinc sensors with lower binding affinities for cellular imaging.
abstract: Zinc sensors based on 2,3-dipicolylamine (DPA) and quinoline have been synthesized. They fluoresced in the presence of Zn(2+) and remained fluorescent when other metal ions were present. Fluorescence enhancement of the sensors was not seen for most other metal ions. In vitro studies with fibroblasts showed fluorescence when sensor and Zn(2+) were present. As seen by single crystal X-ray analysis, four nitrogens from the sensor bind to Zn(2+). These new sensors have lower binding constants than the pentadentate sensors based on 2,2-DPA.
authors: Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul 139-743, Korea.
authors: Jin Hoon
authors: JH
authors: Kim
authors: In Hong
authors: IH
authors: Hwang
authors: Seung Pyo
authors: SP
authors: Jang
authors: Juhye
authors: J
authors: Kang
authors: Sumi
authors: S
authors: Kim
authors: Insup
authors: I
authors: Noh
authors: Youngmee
authors: Y
authors: Kim
authors: Cheal
authors: C
authors: Kim
authors: Roger G
authors: RG
authors: Harrison
mesh_terms: D000588:Amines / Q000737:chemistry*; D002460:Cell Line; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry; D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008670:Metals / Q000737:chemistry; D018613:Microscopy, Confocal; D008968:Molecular Conformation; D010848:Picolinic Acids / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: C501847:2,2'-dipicolylamine; D000588:Amines; D056831:Coordination Complexes; D005456:Fluorescent Dyes; D008670:Metals; D010848:Picolinic Acids; D011804:Quinolines; C037219:quinoline; D015032:Zinc