title: Applications of array-CGH for lung cancer.
abstract: This chapter summarizes the current knowledge on gene copy number changes found in lung tumors, and their application in the diagnosis, prognostication, and prediction of response to chemotherapy. Examples of the identification of specific "driver" oncogenes within amplified DNA segments are described. A model of how array-CGH could be integrated clinically into the routine workup of lung cancers in clinical laboratory is proposed.
authors: Department of Pathology, Toronto General Hospital University Health Network, Toronto, ON, Canada. ken.craddock@utoronto.ca
authors: Kenneth J
authors: KJ
authors: Craddock
authors: Wan L
authors: WL
authors: Lam
authors: Ming-Sound
authors: MS
authors: Tsao
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics; D000818:Animals; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis / Q000235:genetics; D018287:Carcinoma, Large Cell / Q000175:diagnosis / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics; D055028:Comparative Genomic Hybridization / Q000379:methods*; D056915:DNA Copy Number Variations; D018628:Gene Dosage; D006801:Humans; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics*; D008654:Mesothelioma / Q000175:diagnosis / Q000235:genetics; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000235:genetics; D011379:Prognosis