title: Preliminary biological evaluation and mechanism of action studies of selected 2-arylindoles against glioblastoma.
abstract: A series of related 2-arylindoles have been evaluated for their anticancer activity against a range of glioblastoma cell lines using a number of different cell-based assays to determine cell viability after treatment with the compounds. The best indoles, which showed comparable activity to cisplatin against a U87MG cell line in the MTS assay, were taken forward and initial studies suggest that their mechanism of action is consistent with the generation of reactive oxygen species followed by autophagic cell death. Furthermore, activity was also observed in glioblastoma short-term cell cultures for the best lead compound and in some cases gave low micromolar IC50s.
authors: School of Pharmacy and Biomedical Sciences, Maudland Building, University of Central Lancashire, Preston PR1 2HE, UK.
authors: Saurabh
authors: S
authors: Prabhu
authors: Zaheer
authors: Z
authors: Akbar
authors: Frederick
authors: F
authors: Harris
authors: Katherine
authors: K
authors: Karakoula
authors: Robert
authors: R
authors: Lea
authors: Farzana
authors: F
authors: Rowther
authors: Tracy
authors: T
authors: Warr
authors: Timothy
authors: T
authors: Snape
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001343:Autophagy / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D005909:Glioblastoma / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D017382:Reactive Oxygen Species; D002945:Cisplatin