title: LOX-1 is a novel marker for peripheral artery disease in patients with type 2 diabetes.
abstract: OBJECTIVE
  The aim of this study was to investigate whether serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1), which mediates initiation and progression of atherosclerosis in endothelial cells, could be a novel marker for peripheral artery disease (PAD) in patients with type 2 diabetes.
  
  
  METHODS
  We evaluated relationships of serum sLOX-1 to ankle-brachial index (ABI) and examined the association of serum sLOX-1 with PAD in 410 patients with type 2 diabetes.
  
  
  RESULTS
  Serum sLOX-1 was inversely correlated with ABI (r=-0.197, P<0.0001). Stepwise regression analysis demonstrated that serum sLOX-1 (β=-0.168, F=5.571, P<0.05) was independently associated with ABI, and multiple logistic regression analysis demonstrated that serum sLOX-1 (16.254 (1.237-213.651), P=0.0339) was independently associated with PAD.
  
  
  CONCLUSIONS
  Serum sLOX-1 is associated with ABI and it could be a novel marker for PAD in patients with type 2 diabetes.
authors: Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. sayarinapm@hotmail.com
authors: Michiaki
authors: M
authors: Fukui
authors: Muhei
authors: M
authors: Tanaka
authors: Takafumi
authors: T
authors: Senmaru
authors: Mamoru
authors: M
authors: Nakanishi
authors: Jun
authors: J
authors: Mukai
authors: Makoto
authors: M
authors: Ohki
authors: Mai
authors: M
authors: Asano
authors: Masahiro
authors: M
authors: Yamazaki
authors: Goji
authors: G
authors: Hasegawa
authors: Naoto
authors: N
authors: Nakamura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood / Q000737:chemistry; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D010865:Pilot Projects; D012044:Regression Analysis; D051127:Scavenger Receptors, Class E / Q000097:blood* / Q000737:chemistry; D012720:Severity of Illness Index; D012995:Solubility
chemical_list: D015415:Biomarkers; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E