title: Efficacy and safety of a 60-week treatment with candesartan in Japanese patients with mild to moderate chronic heart failure.
abstract: BACKGROUND
  Chronic heart failure (CHF) is an increasingly common cardiovascular disease despite recent advances in its diagnosis and management.
  
  
  RESULTS
  A multicenter, open-label study was designed to assess the efficacy and safety of 60-week treatment with candesartan in Japanese patients with mild to moderate CHF. Primary efficacy endpoints were changes from baseline in plasma brain natriuretic peptide (BNP), left ventricular ejection fraction (LVEF), end-diastolic dimension, and New York Heart Association (NYHA) functional class. Two hundred and eighty-nine eligible patients were divided into 2 groups based on the daily dose at the end of treatment: high-dose (HD, 8mg, N=170) and low-dose (LD, 2 or 4mg, N=119). Neither plasma BNP levels nor LVEF changed from the baseline to the end of treatment in the LD group, whereas BNP significantly improved from 61.6 to 50.1pg/mL (p=0.0005) and LVEF from 57.2 to 60.1% (p=0.0005) in the HD group. The changes in NYHA functional class were comparable between groups: 21.2% improved and 76.3% unchanged in the LD group and 20.6% improved and 79.4% unchanged in the HD group. No safety concerns were observed in either group.
  
  
  CONCLUSIONS
  HD candesartan was more effective in improving plasma BNP levels and cardiac function than LD in Japanese CHF patients. Both LD and HD candesartan were well tolerated in CHF patients.
authors: Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors: Masunori
authors: M
authors: Matsuzaki
authors: Kazuhiro
authors: K
authors: Yamamoto
authors: Masafumi
authors: M
authors: Yano
authors: Koki
authors: K
authors: Nakamura
authors: Yuko
authors: Y
authors: Miyata
authors: Kenkichi
authors: K
authors: Sugiura
authors: Emi
authors: E
authors: Nakata
authors: Hiroyuki
authors: H
authors: Tsutsui
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage*; D044466:Asian People; D001562:Benzimidazoles / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D001713:Biphenyl Compounds; D002908:Chronic Disease; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D012720:Severity of Illness Index; D013318:Stroke Volume; D013777:Tetrazoles / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D015415:Biomarkers; D001713:Biphenyl Compounds; D013777:Tetrazoles; D020097:Natriuretic Peptide, Brain; C081643:candesartan