title: Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals.
abstract: Beyond the well-known effects on blood pressure (BP) of the DASH and the Mediterranean diets, a large number of studies have investigated the possible a BP-lowering effect from different dietary supplements and nutraceuticals, mostly antioxidant agents with a high tolerability and safety profile. In particular, a relatively large body of evidence support the use of potassium, L-arginine, vitamin C, cocoa flavonoids, coenzyme Q10, controlled-release melatonin, and aged garlic extract. However there is a need for data about the long-term safety of a large part of these products. Moreover, further clinical research is advisable to identify between the available active nutraceuticals and those with the best cost-effectiveness and risk-benefit ratio for widespread use in a general population with low added cardiovascular risk related to uncomplicated hypertension.
authors: Medical and Surgical Science Department, University of Bologna, Via Albertoni 15 - Pad. 2, 40138, Bologna, Italy.
authors: Arrigo F G
authors: AF
authors: Cicero
authors: Claudio
authors: C
authors: Borghi
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology*; D019587:Dietary Supplements; D006801:Humans; D006973:Hypertension / Q000178:diet therapy*; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D000975:Antioxidants; D014451:Ubiquinone; C024989:coenzyme Q10