title: New targets for glycosaminoglycans and glycosaminoglycans as novel targets.
abstract: Biological functions of a variety of proteins are mediated via their interaction with glycosaminoglycans (GAGs). The structural diversity within the wide GAG landscape provides individual interaction sites for a multitude of proteins involved in several pathophysiological processes. This 'GAG angle' of such proteins as well as their specific GAG ligands give rise to novel therapeutic concepts for drug development. Current glycomic technologies to elucidate the glycan structure-function relationships, methods to investigate the selectivity and specificity of glycan-protein interactions and existing therapeutic approaches to interfere with GAG-protein interactions are discussed.
authors: ProtAffin Biotechnologie AG, Reininghausstrasse 13a, 8020 Graz, Austria.
authors: Bernd
authors: B
authors: Gesslbauer
authors: Martina
authors: M
authors: Theuer
authors: Daniela
authors: D
authors: Schweiger
authors: Tiziana
authors: T
authors: Adage
authors: Andreas J
authors: AJ
authors: Kungl
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D054794:Glycomics / Q000379:methods; D006025:Glycosaminoglycans / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D011134:Polysaccharides / Q000378:metabolism; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D040901:Proteomics / Q000379:methods
chemical_list: D016207:Cytokines; D006025:Glycosaminoglycans; D011134:Polysaccharides