title: [Effects of molybdenum and hypoxia on the cardiovascular system of experimental animals].
abstract: The investigation had the purpose to study an impact of environmental pollution by molybdenum-containing wastes, and Mo dose-dependent effect on the cardiac structure and function in hypoxic conditions. The experiments were performed with white Wistar rats using electrophysiological and histological investigations, radioimmunoassay, immune-enzyme assay, polarographic and mathematical methods. It was shown that the dose Mo of 0.0125 mg/kg of body mass stimulates and raises the ceiling of the normal heart function (NHFC) by 1.2 km. The toxic dose of 1.25 mg/kg breaks the structure, impairs myocardial performance and reduces NHFC by one half; also, it causes gross disorders in protein metabolism and brings about irreversible structural changes in the myocardium.
authors: Z Kh
authors: ZKh
authors: Sherkhov
authors: Kh A
authors: KhA
authors: Kurdanov
authors: L K
authors: LK
authors: Sherkhova
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006854:Hydrocortisone / Q000097:blood; D000860:Hypoxia / Q000097:blood* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008982:Molybdenum / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D032383:Myocytes, Cardiac; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D007328:Insulin; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D008982:Molybdenum; D003345:Corticosterone; D006854:Hydrocortisone