title: Hypertension subtypes and angiotensin converting enzyme (ACE) gene polymorphism in Indian population.
abstract: OBJECTIVE
  To find out the association of angiotensin converting enzyme (ACE) gene polymorphism with hypertension subtypes in a population from India.
  
  
  METHODS
  Consecutive subjects of either sex, aged > or =18 years attending in temporary field clinics arranged in various localities of Assam and Mizoram were interviewed to record information about socio-demographic characteristics, alcohol consumption and smoking. Three readings of blood pressure, height and weight of all subjects were measured. Hypertension and its subtypes were defined as per JNC-VI criteria. Fasting venous blood samples were collected to estimate blood glucose level and to extract genomic DNA followed by PCR analysis for ACE gene polymorphism.
  
  
  RESULTS
  A total of 916 (male=465, female=451) consecutive subjects comprising of 407 (44.4%) hypertensive subjects and 509 (55.6%) normotensive controls were included in the study. Of the hypertensive subjects, majority (69.0%) had systolic diastolic hypertension with male predominance (70.3% vs. 67.6%) which was followed by isolated diastolic hypertension (16.7%) and isolated systolic hypertension (14.3%). The predominant ACE genotype was Ins/Ins (50.0%) and Del/Del genotype showed lowest prevalence (11.4%). After adjusting confounding variables, the Del/Del genotype revealed significant association with isolated systolic hypertension.
  
  
  CONCLUSIONS
  Del/Del polymorphism of ACE gene showed significant association with ISH in our study population.
authors: Regional Medical Research Centre, NE Region (ICMR), Dibrugarh, Post Box-105, Assam.
authors: P K
authors: PK
authors: Borah
authors: P
authors: P
authors: Shankarishan
authors: N C
authors: NC
authors: Hazarika
authors: J
authors: J
authors: Mahanta
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D003430:Cross-Sectional Studies; D003971:Diastole / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000145:classification / Q000235:genetics*; D007194:India; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D013599:Systole / Q000235:genetics; D055815:Young Adult
chemical_list: D007703:Peptidyl-Dipeptidase A