title: Cerebrospinal fluid oligoclonal IgM bands predict early conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome.
abstract: We reviewed the records of 391 patients who had presented with a Clinically Isolated Syndrome and selected 205 who had performed a baseline spinal tap and MRI scan. We studied cerebrospinal fluid (CSF) and serum IgM oligoclonal bands (IgMOB) using agarose gel isoelectric focusing and analyzed the impact of baseline clinical, MRI and CSF variables on the risk of conversion to clinically definite multiple sclerosis, i.e. on the risk of a clinical relapse. At survival analysis, a lower age at onset, an onset with optic neuritis and the presence of CSF-restricted IgMOB increased the risk of a relapse. Only the presence of CSF-restricted IgMOB predicted a relapse within one year.
authors: Department of Neurosciences, University of Modena and Reggio Emilia, Italy. perdiana@tin.it
authors: Diana
authors: D
authors: Ferraro
authors: Anna Maria
authors: AM
authors: Simone
authors: Roberta
authors: R
authors: Bedin
authors: Veronica
authors: V
authors: Galli
authors: Francesca
authors: F
authors: Vitetta
authors: Lucia
authors: L
authors: Federzoni
authors: Roberto
authors: R
authors: D'Amico
authors: Elisa
authors: E
authors: Merelli
authors: Paolo Frigio
authors: PF
authors: Nichelli
authors: Patrizia
authors: P
authors: Sola
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000276:immunology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid; D008297:Male; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000276:immunology; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013129:Spinal Puncture; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007075:Immunoglobulin M; D043025:Oligoclonal Bands