title: Successful endovascular treatment of three fusiform cerebral aneurysms with the Pipeline Embolization Device in a patient with dilating HIV vasculopathy.
abstract: Dilating HIV vasculopathy can be a cause of ischemic and hemorrhagic stroke in patients with HIV. Although first identified in children, this condition is increasingly being recognized in adults and has a dismal natural history under medical or expectant management. Vessel wall invasion by varicella zoster virus, HIV or Mycobacterium avium intracellulare complex (MAI) has been postulated as a possible etiology. We present a case of an adult patient with HIV and chronic disseminated MAI infection who presented with ischemic stroke and three fusiform cerebral aneurysms that were successfully treated with the pipeline embolization device (PED). Flow diversion may be a viable treatment option for patients presenting with this serious neurovascular condition when aneurysm location precludes parent vessel sacrifice or surgical bypass. In addition, platelet function testing with VerifyNow may be valuable in selecting the appropriate P2Y12 receptor antagonist to be used in order to prevent PED thrombosis, since some of the antiretroviral drugs may inhibit clopidogrel or prasugrel metabolism.
authors: Department of Interventional Neuroradiology, Neuroscience Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA.
authors: Josser E
authors: JE
authors: Delgado Almandoz
authors: Benjamin M
authors: BM
authors: Crandall
authors: Jennifer L
authors: JL
authors: Fease
authors: Jill M
authors: JM
authors: Scholz
authors: Ruth E
authors: RE
authors: Anderson
authors: Yasha
authors: Y
authors: Kadkhodayan
authors: David E
authors: DE
authors: Tubman
mesh_terms: D000328:Adult; D004108:Dilatation, Pathologic / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods*; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D016896:Treatment Outcome
keywords: Aneurysm; Brain; Flow Diverter; Infection; Stroke