title: Antibiotic resistance of Helicobacter pylori isolated in the Southeast Coastal Region of China.
abstract: BACKGROUND
  The resistance of Helicobacter pylori (H. pylori) to antibiotics is increasing worldwide, lowering its efficacy in current eradication therapies. This study evaluated H. pylori resistance to antibiotics in the southeast coastal region of China and suggests appropriate alternatives.
  
  
  METHODS
  Seventeen thousand seven hundred and thirty one H. pylori strains were collected from eight areas of two provinces in coastal southeast China from 2010 to 2012. The resistance of these strains to six antibiotics was tested using the agar dilution method.
  
  
  RESULTS
  The resistance rates to clarithromycin, metronidazole, levofloxacin, amoxicillin, gentamicin and furazolidone were 21.5, 95.4, 20.6, 0.1, 0.1 and 0.1%, respectively. Double, triple and quadruple antibacterial resistant percentages were 25.5, 7.5 and 0.1%, respectively. A positive association between the resistance to levofloxacin and to clarithromycin was found, but there was a negative correlation in the resistances to levofloxacin and to metronidazole.
  
  
  CONCLUSIONS
  The prevalence of H. pylori resistance to clarithromycin, metronidazole, levofloxacin and multiple antibiotics in coastal southeast China is high. Choice of therapy should be individualized based on a susceptibility test in this region of the country.
authors: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors: Peng
authors: P
authors: Su
authors: Youming
authors: Y
authors: Li
authors: Hongzhang
authors: H
authors: Li
authors: Jiakun
authors: J
authors: Zhang
authors: Lang
authors: L
authors: Lin
authors: Qunying
authors: Q
authors: Wang
authors: Feng
authors: F
authors: Guo
authors: Zizhong
authors: Z
authors: Ji
authors: Jibo
authors: J
authors: Mao
authors: Wuheng
authors: W
authors: Tang
authors: Zhengchao
authors: Z
authors: Shi
authors: Wei
authors: W
authors: Shao
authors: Junliang
authors: J
authors: Mao
authors: Xinjian
authors: X
authors: Zhu
authors: Xiaofeng
authors: X
authors: Zhang
authors: Yuefeng
authors: Y
authors: Tong
authors: Huimin
authors: H
authors: Tu
authors: Mizu
authors: M
authors: Jiang
authors: Zhiyong
authors: Z
authors: Wang
authors: Fengzhe
authors: F
authors: Jin
authors: Ningmin
authors: N
authors: Yang
authors: Jianzhong
authors: J
authors: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D024881:Drug Resistance, Bacterial; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D015995:Prevalence
chemical_list: D000900:Anti-Bacterial Agents