title: One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: three years results.
abstract: Osteochondral lesions of the knee (OLK) are a common cause of knee pain and associated diseases. A new bone-marrow-derived mesenchymal stem cells technique has been developed for the treatment of OLK. 30 patients with OLK underwent arthroscopic one-step procedure. The bone marrow was harvested from the patients' posterior iliac crest and arthroscopically implanted with a scaffold into the lesion site. Clinical inspection and MRI were performed. Mean International Knee Documentation Committee (IKDC) score before surgery was 29.9 ± 13.2 and 85.4 ± 4.2 at 29 ± 4.1 months (p < 0.0005), while Knee injury and Osteoarthritis Outcome Score (KOOS) before surgery was 35.1 ± 11.9 and 87.3 ± 7.3 at 29 ± 4.1 months (p < 0.0005). Control MRI and bioptic samples showed an osteochondral regeneration of the lesion site. The one-step technique appears to be a good and reliable option for treatment of OLK at three years of follow-up. Level of evidence Case series, Level IV.
authors: Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy.
authors: Roberto
authors: R
authors: Buda
authors: Francesca
authors: F
authors: Vannini
authors: Marco
authors: M
authors: Cavallo
authors: Matteo
authors: M
authors: Baldassarri
authors: Deianira
authors: D
authors: Luciani
authors: Antonio
authors: A
authors: Mazzotti
authors: Camilla
authors: C
authors: Pungetti
authors: Alessandra
authors: A
authors: Olivieri
authors: Sandro
authors: S
authors: Giannini
mesh_terms: D001182:Arthroscopy / Q000379:methods*; D016026:Bone Marrow Transplantation; D002357:Cartilage Diseases / Q000601:surgery*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D013997:Time Factors