title: Prognostic significance of tumor location and superficial urothelial bladder carcinoma history in patients with ureteral urothelial carcinoma treated with radical nephroureterectomy.
abstract: OBJECTIVE
  To investigate the significance of tumor location and superficial urothelial bladder carcinoma (UBC) history on oncological outcomes in patients treated with radical nephroureterectomy (RNU) for ureteral urothelial carcinoma (UC).
  
  
  METHODS
  One hundred and thirty-two patients treated with RNU for ureteral UC between January 1999 and July 2010 were retrospectively analyzed. Recurrence probabilities and survival rates were analyzed, stratified by tumor location and superficial UBC history.
  
  
  RESULTS
  Comparison of patients with proximal, middle, and distal ureteral UC showed that percentage of bladder recurrence was 13.3, 14.7, and 25.0 %, respectively (P = 0.285); retroperitoneal (tumor bed or lymph node) recurrence was 26.7, 14.7, and 27.9 % (P = 0.319); and contralateral recurrence was 0, 2.9, and 0 % (P = 0.234). Comparison of patients with and without history of superficial UBC revealed that percentage of bladder recurrence was 15.4 and 20.2 %, respectively (P = 0.681); retroperitoneal recurrence was 15.4 and 25.2 % (P = 0.433); and contralateral recurrence was 0 and 0.84 % (P = 0.740). Using multivariable Cox regression analyses, there were no significant differences of recurrence-free survival (RFS) and cancer-specific survival (CSS) with regard to neither tumor location nor superficial UBC history (RFS: P = 0.282 and 0.762, CSS: P = 0.272 and 0.818, respectively).
  
  
  CONCLUSIONS
  Tumor location and history of superficial UBC could not be used to predict oncological outcomes of patients who underwent RNU for ureteral UC. Therefore, operative strategies or postoperative surveillance should not be affected by tumor location or history of superficial UBC.
authors: State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, People's Republic of China.
authors: Jian-Ye
authors: JY
authors: Liu
authors: Qun
authors: Q
authors: Zhang
authors: Yun-Lin
authors: YL
authors: Ye
authors: Jing
authors: J
authors: Li
authors: Wei
authors: W
authors: Chen
authors: Yong-Hong
authors: YH
authors: Li
authors: Zhi-Ling
authors: ZL
authors: Zhang
authors: Kai
authors: K
authors: Yao
authors: Li-Juan
authors: LJ
authors: Jiang
authors: Hui
authors: H
authors: Han
authors: Zhou-Wei
authors: ZW
authors: Liu
authors: Zi-Ke
authors: ZK
authors: Qin
authors: Fang-Jian
authors: FJ
authors: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D014513:Ureter / Q000601:surgery*; D014516:Ureteral Neoplasms / Q000473:pathology* / Q000601:surgery*; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery*; D055815:Young Adult