title: Relapsing-remitting multiple sclerosis and chronic idiopathic neutropenia: a challenging combination.
abstract: We report the challenges of treating relapsing-remitting multiple sclerosis (MS) in a 31-year-old woman with long-standing chronic idiopathic neutropenia. The treatment with the disease-modifying therapy interferon-β was significantly complicated by a further fall in her generally low neutrophil count, to values below 0.5×10(9)/l, although this recovered rapidly when the treatment was stopped. We discuss the difficulties of balancing the risk of neutropenia with a risk of MS relapse.
authors: Centre for Regenerative Medicine, University of Edinburgh, Edinburgh,  UK.
authors: Eva Jolanda
authors: EJ
authors: Münzel
authors: Jennie Z
authors: JZ
authors: Wimperis
authors: Anna
authors: A
authors: Williams
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects / Q000627:therapeutic use; D016899:Interferon-beta / Q000008:administration & dosage / Q000627:therapeutic use; D007958:Leukocyte Count; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D009503:Neutropenia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D009504:Neutrophils / Q000473:pathology
chemical_list: D007155:Immunologic Factors; D016899:Interferon-beta