title: Gold-containing bioactive glasses: a solid-state synthesis to produce alternative biomaterials for bone implantations.
abstract: A new melted bioactive system containing gold nanoparticles (AuNPs) was prepared exploiting a post-synthesis thermal treatment that allows one to modify crystal phases and nature, shape and distribution of the gold species in the glass-ceramic matrix as evidenced by UV-visible spectroscopy, transmission electron microscopy and powder X-ray diffraction analysis. In human MG-63 osteoblasts the presence of Au(n)(+) species caused an increase of lactate dehydrogenase leakage and malonyldialdehyde production, whereas Hench's Bioglass HAu-600-17 containing only AuNPs did not cause any effect. In addition, HAu-600-17 caused in vitro hydroxyapatite formation and an increase of specific surface area with a controlled release of gold species; this material is then suitable to be used as a model system for the controlled delivery of nanoparticles.
authors: Department of Chemistry, University of Torino, Torino, Italy.
authors: Valentina
authors: V
authors: Aina
authors: Giuseppina
authors: G
authors: Cerrato
authors: Gianmario
authors: G
authors: Martra
authors: Loredana
authors: L
authors: Bergandi
authors: Costanzo
authors: C
authors: Costamagna
authors: Dario
authors: D
authors: Ghigo
authors: Gianluca
authors: G
authors: Malavasi
authors: Gigliola
authors: G
authors: Lusvardi
authors: Ledi
authors: L
authors: Menabue
mesh_terms: D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002516:Ceramics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017886:Durapatite / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*
chemical_list: D018786:Bone Substitutes; D008315:Malondialdehyde; D006046:Gold; C023506:Glass ceramics; D017886:Durapatite; D007770:L-Lactate Dehydrogenase