title: New polyaromatic metabolites from a marine-derived fungus Penicillium sp.
abstract: Herqueiazole (1), herqueioxazole (2), and herqueidiketal (3), polyaromatic metabolites with a novel skeletal class, were isolated from the marine-derived fungus Penicillium sp. Based on the combined spectroscopic analyses, the structures of 1 and 2 were determined to be the first examples of pyrrole- and oxazole-containing phenalenone compounds, respectively, whereas 3 possessed a novel skeleton with a highly oxidized naphthoquinone moiety. Compound 3 exhibited moderate cytotoxicity and significant inhibitory activity against sortase A.
authors: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors: Elin
authors: E
authors: Julianti
authors: Jung-Ho
authors: JH
authors: Lee
authors: Lijuan
authors: L
authors: Liao
authors: Wanki
authors: W
authors: Park
authors: Sunghyouk
authors: S
authors: Park
authors: Dong-Chan
authors: DC
authors: Oh
authors: Ki-Bong
authors: KB
authors: Oh
authors: Jongheon
authors: J
authors: Shin
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C582261:herqueiazole; C582263:herqueidiketal; C582262:herqueioxazole