title: Analysis of CD137L and IL-17 expression in tumor tissue as prognostic indicators for gliblastoma.
abstract: Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability and unpredictable clinical behavior. GBM is marked by an extremely poor prognosis with median overall survival of 12~14 months. In this study, we detected the CD137L-expressing cells and IL-17-expressing cells in tumor tissues resected from patients with GBM. Expression of CD137L and IL-17 were assessed by immunohistochemistry, and the prognostic value of CD137L and IL-17 expression within the tumor tissues were assessed by Cox regression and Kaplan-Meier analysis. Immunohistochemical detection showed that positive cells of CD137L and IL-17 in glioblastoma tissue samples were 46.3% (19/ 41) and 73.2% (30/41) respectively. Expression of CD137L was not correlated with overall survival of GBM patients (P=0.594), while significantly longer survival rate was seen in patients with high expression of IL-17, compared to those with low expression of IL-17 (P=0.007). In addition, we also found that IL-17 expression was significantly correlated with Progression-free survival (PFS) (P=0.016) and death rate (P=0.01). Furthermore, multivariate Cox proportional hazard analyses revealed that IL-17 (P=0.018) and PFS (P=0.028) were independent factors affecting the overall survival probability. Kaplan-Meier analysis showed that PFS of high expression of IL-17 group were significantly longer (P=0.004) than low expression group with GBM. It is concluded that high levels of IL-17 expression in the tumor tissues may be a good prognostic marker for patients with GBM.
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, PR China.
authors: Xiangli
authors: X
authors: Cui
authors: Zhiqin
authors: Z
authors: Xu
authors: Zhigang
authors: Z
authors: Zhao
authors: Dali
authors: D
authors: Sui
authors: Xiaohui
authors: X
authors: Ren
authors: Qiming
authors: Q
authors: Huang
authors: Jiazhen
authors: J
authors: Qin
authors: Limin
authors: L
authors: Hao
authors: Zhenguang
authors: Z
authors: Wang
authors: Li
authors: L
authors: Shen
authors: Song
authors: S
authors: Lin
mesh_terms: D053330:4-1BB Ligand / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D005909:Glioblastoma / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D053330:4-1BB Ligand; D015415:Biomarkers; D020381:Interleukin-17
keywords: CD137L; Interleukin-17; glioblastoma; overall survival.