title: Chimeric Ply187 endolysin kills Staphylococcus aureus more effectively than the parental enzyme.
abstract: Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall-binding domain is a potent agent against Staphylococcus aureus in four functional assays.
authors: ABBL, BARC, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA.
authors: Jinzhe
authors: J
authors: Mao
authors: Mathias
authors: M
authors: Schmelcher
authors: William J
authors: WJ
authors: Harty
authors: Juli
authors: J
authors: Foster-Frey
authors: David M
authors: DM
authors: Donovan
mesh_terms: D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism*; D050296:Microbial Viability / Q000187:drug effects*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology*
chemical_list: D011993:Recombinant Fusion Proteins; D010450:Endopeptidases; C001143:endolysin