title: A guide to integrating transcriptional regulatory and metabolic networks using PROM (probabilistic regulation of metabolism).
abstract: The integration of transcriptional regulatory and metabolic networks is a crucial step in the process of predicting metabolic behaviors that emerge from either genetic or environmental changes. Here, we present a guide to PROM (probabilistic regulation of metabolism), an automated method for the construction and simulation of integrated metabolic and transcriptional regulatory networks that enables large-scale phenotypic predictions for a wide range of model organisms.
authors: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg. evangelos.simeonidis@uni.lu
authors: Evangelos
authors: E
authors: Simeonidis
authors: Sriram
authors: S
authors: Chandrasekaran
authors: Nathan D
authors: ND
authors: Price
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D053263:Gene Regulatory Networks; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008957:Models, Genetic; D018709:Statistics, Nonparametric; D049490:Systems Biology