title: Effects of lamotrigine on behavior, oxidative parameters and signaling cascades in rats exposed to the chronic mild stress model.
abstract: The rats were subjected to 40 days of stress protocol, during which the sucrose consumption was assessed in rats chronically treated with lamotrigine (20mg/kg) or with saline. The signaling cascade and oxidative stress parameters were assessed in the brain rat. Both control and stressed rats treated with lamotrigine showed an increase on malondialdehyde equivalents (MDA) in the prefrontal cortex, and that there was also an increase in the amygdala of the control rats treated with lamotrigine. The carbonyl protein was increased in the prefrontal cortex of the stressed group treated with saline, however, the lamotrigine treatment reversed this effect. The treatment with lamotrigine increased the superoxide dismutase (SOD) and catalase activity (CAT) activities in the amygdala of stressed rats. The protein kinase B (PKB/Akt) was reduced in the amygdala in the stressed group treated with saline or lamotrigine. We suggest that the antidepressant-like effect of lamotrigine on anhedonic behavior may be related at least in part to its effects on the oxidative stress parameters and AKT.
authors: Laboratório de Neurociências, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), and Núcleo de Excelência em Neurociências Aplicadas de Santa Catarina (NENASC), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil.
authors: Helena M
authors: HM
authors: Abelaira
authors: Gislaine Z
authors: GZ
authors: Réus
authors: Karine F
authors: KF
authors: Ribeiro
authors: Amanda V
authors: AV
authors: Steckert
authors: Francielle
authors: F
authors: Mina
authors: Daniela V F
authors: DV
authors: Rosa
authors: Cíntia V
authors: CV
authors: Santana
authors: Marco Aurélio
authors: MA
authors: Romano-Silva
authors: Felipe
authors: F
authors: Dal-Pizzol
authors: João
authors: J
authors: Quevedo
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D002374:Catalase / Q000378:metabolism; D002908:Chronic Disease; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects*; D005518:Food Preferences / Q000187:drug effects; D000077213:Lamotrigine; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation / Q000187:drug effects; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects*; D013315:Stress, Psychological / Q000188:drug therapy / Q000503:physiopathology*; D013395:Sucrose / Q000008:administration & dosage; D013482:Superoxide Dismutase / Q000378:metabolism; D013549:Sweetening Agents / Q000008:administration & dosage; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014227:Triazines / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D002121:Calcium Channel Blockers; D013549:Sweetening Agents; D017392:Thiobarbituric Acid Reactive Substances; D014227:Triazines; D008315:Malondialdehyde; D013395:Sucrose; D002374:Catalase; D013482:Superoxide Dismutase; D051057:Proto-Oncogene Proteins c-akt; D000077213:Lamotrigine