title: Stability studies of ascorbic acid 2-glucoside in cosmetic lotion using surface response methodology.
abstract: Ascorbic acid 2-glucoside (AA-2G) has been widely used in cream and lotion types of cosmetic products. Thus, the degradation of AA-2G caused by the temperature change and pH variation was very critical for determining the bio-functionality of cosmetics. Response surface methodology (RSM) was introduced to study the influence of temperature and pH on the stability of AA-2G. The optimal condition of retaining AA-2G with the highest stability was determined to be 55.3°C and pH 6.4. The antioxidative activities of AA-2G including DPPH and ABTS free radical scavenging activities, metal chelating activity, and reducing ability were also determined. AA-2G was a good ascorbic acid derivative which could be used in cosmetic products as an active ingredient.
authors: Department of Applied Cosmetology and Graduate Institute of Cosmetic Science, Hung-kuang University, Taiwan.
authors: Wen-Ying
authors: WY
authors: Huang
authors: Pei-Chi
authors: PC
authors: Lee
authors: Ling-Kuei
authors: LK
authors: Huang
authors: Li-Ping
authors: LP
authors: Lu
authors: Wayne C
authors: WC
authors: Liao
mesh_terms: D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry; D003358:Cosmetics / Q000737:chemistry*; D004355:Drug Stability; D016166:Free Radical Scavengers / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008670:Metals / Q000737:chemistry; D010084:Oxidation-Reduction; D013696:Temperature
chemical_list: D002614:Chelating Agents; D003358:Cosmetics; D016166:Free Radical Scavengers; D008670:Metals; C065378:ascorbic acid 2-O-glucoside; D001205:Ascorbic Acid