title: Effects and differentiation activity of IGF-I, IGF-II, insulin and preptin on human primary bone cells.
abstract: The importance of the complex interrelated regulatory pathways involving IGF factors and pancreatic hormones can be observed in several metabolic diseases, where the deregulation of these factors has a wide impact on bone health. These findings have stimulated us to compare the effect of IGF-I, IGF-II, insulin and preptin on human bone cells. The effect on cell differentiation and cell activity of osteoblasts and osteoclasts has been analysed. We have observed a significant effect by IGF-I, a modest effect by IGF-II and preptin and no effect after insulin administration on human primary osteoblast-like cells. All studied factors have shown an induction on human primary osteoclast differentiation and bone resorption activity, with IGF-I being the most potent factor. We hypothesize that these findings may be on the basis of decreased bone mass density observed in several diseases.
authors: Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale A. Avogadro, Alessandria, Novara, Vercelli, Italy.
authors: Michela
authors: M
authors: Bosetti
authors: Maurizio
authors: M
authors: Sabbatini
authors: Elena
authors: E
authors: Nicolì
authors: Luca
authors: L
authors: Fusaro
authors: Mario
authors: M
authors: Cannas
mesh_terms: D001862:Bone Resorption / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D007335:Insulin-Like Growth Factor II / Q000378:metabolism / Q000494:pharmacology; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism / Q000494:pharmacology
chemical_list: D007328:Insulin; D010446:Peptide Fragments; C443100:preptin; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II