title: Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese population.
abstract: OBJECTIVE
  Genetic variants of telomerase reverse transcriptase (TERT) and cleft lip and palate trans-membrane 1 like (CLPTM1L) genes in chromosome 5p15.33 region were previously identified to influence the susceptibility to lung cancer. We examined the association of single nucleotide polymorphisms (SNPs) in TERT and CLPTM1L genes with lung cancer and explored their potential modifying effects on the relationship between environmental risk factors and lung cancer in a Chinese population.
  
  
  METHODS
  We genotyped rs2736100 (TERT) and rs401681 (CLPTM1L) SNPs in a case-control study with 399 lung cancer cases and 466 controls form Taiyuan, China. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models. Potential confounders were controlled for in the adjusted models.
  
  
  RESULTS
  We found that the GG genotype of TERT was positively associated with lung cancer (OR=1.47, 95% CI: 1.00-2.16). The association was stronger in participants older than 60years, exposed to low indoor air pollution and adenocarcinoma and squamous cell carcinoma (SCC) in recessive model analysis. The GA genotype of CLPTM1L was inversely associated with lung cancer (OR=0.72, 95% CI: 0.54-0.97). The association was stronger in participants 60 years old or younger, males, heavy smokers, exposed to low indoor air pollution and SCC in dominant model analysis. Individuals carrying both TERT and CLPTM1L risk genotypes had higher risk of lung cancer (OR=1.80, 95% CI: 1.15-2.82). Significant interaction was observed between CLPTM1L and indoor air pollution in association with lung cancer.
  
  
  CONCLUSIONS
  Our results reiterate that genetic variants of TERT and CLPTM1L contribute to lung cancer susceptibility in Chinese population. These associations need to be verified in larger and different populations.
authors: Department of Social and Preventive, School of Public Health and Health Professions, State University of New York (SUNY) at Buffalo, Buffalo, NY 14221, USA.
authors: Ajay A
authors: AA
authors: Myneni
authors: Shen-Chih
authors: SC
authors: Chang
authors: Rungui
authors: R
authors: Niu
authors: Li
authors: L
authors: Liu
authors: Heather M
authors: HM
authors: Ochs-Balcom
authors: Yanli
authors: Y
authors: Li
authors: Chao
authors: C
authors: Zhang
authors: Baoxing
authors: B
authors: Zhao
authors: Jianping
authors: J
authors: Shi
authors: Xiaoyou
authors: X
authors: Han
authors: Jiawei
authors: J
authors: Li
authors: Jia
authors: J
authors: Su
authors: Lin
authors: L
authors: Cai
authors: Shunzhang
authors: S
authors: Yu
authors: Zuo-Feng
authors: ZF
authors: Zhang
authors: Lina
authors: L
authors: Mu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D019098:Telomerase / Q000235:genetics*
chemical_list: C422445:CLPTM1L protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C509186:TERT protein, human; D019098:Telomerase