title: Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: influence of Gleason score, treatment and bone metastasis.
abstract: The relation between adenine nucleotides and cancer has already been described in literature. Considering that the enzymes ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) act together to control nucleotide levels, we aimed to investigate the role of these enzymes in prostate cancer (PCa). E-NPP and ADA activities were determined in serum and platelets of PCa patients and controls. We also verified the influence of the Gleason score, bone metastasis and treatment in the enzyme activities. Platelets and serum E-NPP activity increased, whereas ADA activity in serum decreased in PCa patients. In addition, Gleason score, metastasis and treatment influenced E-NPP and ADA activities. We may propose that E-NPP and ADA are involved in the development of PCa. Moreover, E-NPP and ADA activities are modified in PCa patients with distinct Gleason score, with bone metastasis, as well as in patients under treatment.
authors: Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, 97105-900 Santa Maria, RS, Brazil. battistivanessa@gmail.com
authors: Vanessa
authors: V
authors: Battisti
authors: Liési D K
authors: LD
authors: Maders
authors: Margarete D
authors: MD
authors: Bagatini
authors: Iara E
authors: IE
authors: Battisti
authors: Luziane P
authors: LP
authors: Bellé
authors: Karen F
authors: KF
authors: Santos
authors: Paula A
authors: PA
authors: Maldonado
authors: Gustavo R
authors: GR
authors: Thomé
authors: Maria R C
authors: MR
authors: Schetinger
authors: Vera M
authors: VM
authors: Morsch
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001859:Bone Neoplasms / Q000201:enzymology* / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010727:Phosphoric Diester Hydrolases / Q000097:blood / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000473:pathology* / Q000628:therapy; D011755:Pyrophosphatases / Q000097:blood / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D010727:Phosphoric Diester Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1; D000243:Adenosine Deaminase; D011755:Pyrophosphatases