title: Frequency of fibroblast growth factor receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome.
abstract: OBJECTIVE
  Novel therapies are required for patients with recurrent or metastatic oral tongue squamous cell carcinoma (OTSCC). Fibroblast Growth Factor Receptor 1 (FGFR1) amplification frequently occurs in squamous cell carcinoma of the lung and represents a novel druggable therapeutic target in this and other malignancies. This study examined the frequency and clinical associations of FGFR1 amplification in OTSCC.
  
  
  METHODS
  The frequency of FGFR1 amplification determined by fluorescence in situ hybridization was evaluated in a cohort of 123 OTSCC patients. Associations of FGFR1 amplification with clinical characteristics and outcome were determined.
  
  
  RESULTS
  FGFR1 gene amplification was present in 9.3% (10/107) of cases and was significantly associated with smoking status (P = 0.03). FGFR1 amplification was seen more commonly in males (9/10 amplified cases male, P = 0.16) and there were no associations with age, stage, T stage, nodal status, alcohol history or performance status (all P>0.05). Outcome was not significantly different between FGFR1 amplified and non-amplified patients.
  
  
  CONCLUSIONS
  Copy number variations of the FGFR1 gene occur in a subset of OTSCC with approximately 10% of cases showing amplification of the gene. FGFR1 amplification may represent a therapeutic target in OTSCC.
authors: Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia.
authors: Richard J
authors: RJ
authors: Young
authors: Annette M
authors: AM
authors: Lim
authors: Christopher
authors: C
authors: Angel
authors: Marnie
authors: M
authors: Collins
authors: Siddhartha
authors: S
authors: Deb
authors: June
authors: J
authors: Corry
authors: David
authors: D
authors: Wiesenfeld
authors: Stephen
authors: S
authors: Kleid
authors: Elizabeth
authors: E
authors: Sigston
authors: Bernard
authors: B
authors: Lyons
authors: Prudence A
authors: PA
authors: Russell
authors: Gavin
authors: G
authors: Wright
authors: Grant A
authors: GA
authors: McArthur
authors: Stephen B
authors: SB
authors: Fox
authors: Danny
authors: D
authors: Rischin
authors: Benjamin
authors: B
authors: Solomon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D005784:Gene Amplification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics*; D014062:Tongue Neoplasms / Q000235:genetics* / Q000473:pathology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C496348:FGFR1 protein, human; D051496:Receptor, Fibroblast Growth Factor, Type 1