title: Anti-depressant effects of aqueous extract from Acanthopanax senticosus in mice.
abstract: In this paper, the anti-depressant effects of Acanthopanax senticosus extract (ASE) were studied using animal models of depression including the forced swimming and tail suspension tests. The anti-depressive mechanism of ASE was explored by monitoring the levels of monoamine neurotransmitters including 5-hydroxytrylamine (5-HT), norepinephrine (NE), and dopamine (DA), as well as cAMP response element-binding (CREB) protein expression in the whole brain of mice following the tail suspension test. Our results showed that intragastric administration of ASE at a dose of 2000 mg/kg for seven days significantly reduced the duration of immobility in both the forced swimming test and the tail suspension test. These results indicate that ASE possesses antidepressant-like properties. Pre-treatment with 2000 mg/kg of ASE for seven days significantly elevated the levels of 5-HT, NE, and DA in the whole brain of mice. Moreover, ASE at doses of 1000 and 2000 mg/kg significantly up-regulated the level of CREB protein. Taken together, these findings suggest that the anti-depressive mechanism of ASE may be mediated via the central monoaminergic neurotransmitter system and CREB protein expression. Therefore, administration of ASE may be beneficial for patients with depressive disorders.
authors: School of Life Science and Biotechnology, Dalian University of Technology, Dalian, 116024, P. R. China; Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian, 116620, P. R. China.
authors: Liji
authors: L
authors: Jin
authors: Feifei
authors: F
authors: Wu
authors: Xiaoyu
authors: X
authors: Li
authors: Huaqiang
authors: H
authors: Li
authors: Chong
authors: C
authors: Du
authors: Qi
authors: Q
authors: Jiang
authors: Jiansong
authors: J
authors: You
authors: Shuying
authors: S
authors: Li
authors: Yongping
authors: Y
authors: Xu
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D028001:Eleutherococcus / Q000737:chemistry*; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; C492004:Creb1 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D010936:Plant Extracts; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine
keywords: Acanthopanax senticosus extract; CREB protein; anti-depressant; forced swimming test; monoamine neurotransmitters; tail suspension test