title: When are the BET factors the most sensitive to bromodomain inhibitors?
abstract: The recent publication of two detailed studies of mouse spermatogenesis, either after chemical inhibition of the BET bromodomains, or in the context of genetic alterations of one specific BET member, Brdt, provides the unique opportunity to assess the functional impact of BET bromodomain inhibitors.
authors: INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot Grenoble, France. khochbin@ujf-grenoble.fr
authors: Saadi
authors: S
authors: Khochbin
mesh_terms: D000818:Animals; D001381:Azepines / Q000494:pharmacology; D002868:Chromosomal Proteins, Non-Histone; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013091:Spermatogenesis / Q000187:drug effects; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014230:Triazoles / Q000494:pharmacology; D000092468:Bromodomain Containing Proteins
chemical_list: D001381:Azepines; D002868:Chromosomal Proteins, Non-Histone; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; D011956:Receptors, Cell Surface; D014157:Transcription Factors; D014230:Triazoles; C561695:(+)-JQ1 compound; C518475:BRDT protein, mouse; D000092468:Bromodomain Containing Proteins; C490844:Brd2 protein, mouse; C518476:Brd3 protein, mouse; C486694:Brd4 protein, mouse; C486765:Dner protein, mouse
keywords: Brd2; Brd3; Brd4; Brdt; acetylation; cancer; chromatin; histone; infertility; pTEFb; spermatogenesis