title: Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells.
abstract: The first example of synchrotron X-ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine-labelled cyclic RGD peptide and its effects on the biodistribution of endogenous elements (for example, K and Cl) within individual tumor cells.
authors: School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
authors: Erin J
authors: EJ
authors: Sheridan
authors: Christopher J D
authors: CJ
authors: Austin
authors: Jade B
authors: JB
authors: Aitken
authors: Stefan
authors: S
authors: Vogt
authors: Katrina A
authors: KA
authors: Jolliffe
authors: Hugh H
authors: HH
authors: Harris
authors: Louis M
authors: LM
authors: Rendina
mesh_terms: D000818:Animals; D001966:Bromine; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008546:Melanoma, Experimental / Q000378:metabolism*; D051379:Mice; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000493:pharmacokinetics*; D013052:Spectrometry, X-Ray Emission / Q000379:methods; D014407:Tumor Cells, Cultured
chemical_list: D009842:Oligopeptides; D010456:Peptides, Cyclic; C507169:cyclic arginine-glycine-aspartic acid peptide; C047981:arginyl-glycyl-aspartic acid; D001966:Bromine
keywords: RGD peptide; XRF; microprobe; tumor cells