title: Sesquiterpene coumarin and sesquiterpene chromone derivatives from Ferula ferulaeoides (Steud.) Korov.
abstract: Five novel compounds - three sesquiterpene coumarin derivatives, ferulin A (1), B (2), and C (3), and two sesquiterpene chromone derivatives, ferulin D (4) and E (5), together with eleven known compounds (6-16) have been isolated from the roots of Ferula ferulaeoides (Steud.) Korov. Their structures were established by comprehensive spectroscopic analysis. The biosynthetic pathways leading to these compounds were proposed. The cytotoxicity of all these isolates against HepG2, MCF-7, and C6 cancer cell lines was evaluated and compound 7 displayed the highest potency against HepG2, MCF-7, and C6 with IC50 values 39.9 μM, 37.7 μM, and 16.0 μM, respectively.
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors: He
authors: H
authors: Meng
authors: Guoyu
authors: G
authors: Li
authors: Jian
authors: J
authors: Huang
authors: Ke
authors: K
authors: Zhang
authors: Hangyu
authors: H
authors: Wang
authors: Jinhui
authors: J
authors: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D002867:Chromones / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D005309:Ferula / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002867:Chromones; D003374:Coumarins; D010936:Plant Extracts; D012717:Sesquiterpenes