title: Prion protein gene M129V polymorphism and variability in age at migraine onset.
abstract: Prion protein, a sialoglycoprotein with neuroprotective properties on oxidative stress damage, has been related with the mechanisms leading to migraine. In the present case-control study, we investigated the correlation between the common methionine/valine polymorphism at codon 129 within the prion protein gene (PRNP) and migraine. Genotyping of PRNP V129M variant was performed in 384 migraine patients and 185 age-, sex-, and race-ethnicity-matched healthy controls. The frequencies of the PRNP V129M genotype did not differ significantly between migraineurs and controls. The frequencies of 129VV genotype were significantly higher in patients with earlier age at migraine onset. No correlation was found between PRNP 129 genotype and demographics, and other clinical migraine features. Our data suggest that the PRNP 129VV polymorphism is not a direct migraine risk factor but is significantly associated with an earlier onset of the disease.
authors: Laboratory of Molecular Diagnostics, Interinstitutional Multidisciplinary BioBank (BioBIM), Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele Pisana, Rome, Italy.
authors: Raffaele
authors: R
authors: Palmirotta
authors: Giorgia
authors: G
authors: Ludovici
authors: Gabriella
authors: G
authors: Egeo
authors: Cristiano
authors: C
authors: Ialongo
authors: Cinzia
authors: C
authors: Aurilia
authors: Luisa
authors: L
authors: Fofi
authors: Maria Laura
authors: ML
authors: De Marchis
authors: David
authors: D
authors: Della-Morte
authors: Piero
authors: P
authors: Barbanti
authors: Fiorella
authors: F
authors: Guadagni
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011328:Prions / Q000235:genetics*; D012189:Retrospective Studies; D013223:Statistics as Topic; D014633:Valine / Q000235:genetics*
chemical_list: D011328:Prions; D008715:Methionine; D014633:Valine