title: Criteria for an updated classification of human transcription factor DNA-binding domains.
abstract: By binding to cis-regulatory elements in a sequence-specific manner, transcription factors regulate the activity of nearby genes. Here, we discuss the criteria for a comprehensive classification of human TFs based on their DNA-binding domains. In particular, classification of basic leucine zipper (bZIP) and zinc finger factors is exemplarily discussed. The resulting classification can be used as a template for TFs of other biological species.
authors: Department of Bioinformatics, University Medical Center Göttingen, Goldschmidtstr. 1, Göttingen, D-37077, Germany. edgar.wingender@bioinf.med.uni-goettingen.de
authors: Edgar
authors: E
authors: Wingender
mesh_terms: D000465:Algorithms; D001665:Binding Sites; D004247:DNA / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D012984:Software; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors; D004247:DNA