title: Chromosomal abnormalities by conventional cytogenetics and interphase fluorescence in situ hybridization in chronic lymphocytic leukemia in Taiwan, an area with low incidence--clinical implication and comparison between the West and the East.
abstract: Chronic lymphocytic leukemia (CLL) is much less prevalent in Taiwan than in the West, but we have recently addressed the distinctly increasing incidence of CLL in Taiwan. We sought to find out whether there is any difference in cytogenetic abnormalities (CA) of CLL between the West and the East. We analyze the CA, by conventional cytogenetics (CG) and fluorescence in situ hybridization (FISH), and their clinical significance in 83 Taiwanese CLL patients and compared the data to those of Western countries. Thirty-five patients (42.2 %) possessed CG-CA and 58 (69.9 %) FISH-CA. By either CG or FISH, deletion of 17p or 11q was associated with poorer overall survival (OS) (P<0.001 and P=0.008, respectively), whereas isolated 13q deletion was associated with better OS (P=0.050). Trisomy 3 by CG was found in five patients; all of them were in Binet A stage but had strikingly poor OS (P<0.001). This prognostic impact was independent from the other CA and Binet stages. We conclude that, though the disease incidence is much different, the CA of CLL in Taiwan are similar to those in the West. The combined CG and FISH analysis is able to predict the patients' prognosis. The clinical significance of trisomy 3 warrants further validation.
authors: Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100, Taiwan.
authors: Shang-Ju
authors: SJ
authors: Wu
authors: Chien-Ting
authors: CT
authors: Lin
authors: Sheng-Yi
authors: SY
authors: Huang
authors: Fen-Yu
authors: FY
authors: Lee
authors: Ming-Chi
authors: MC
authors: Liu
authors: Hsin-An
authors: HA
authors: Hou
authors: Chien-Yuan
authors: CY
authors: Chen
authors: Bor-Sheng
authors: BS
authors: Ko
authors: Wen-Chien
authors: WC
authors: Chou
authors: Ming
authors: M
authors: Yao
authors: Jih-Luh
authors: JL
authors: Tang
authors: Woei
authors: W
authors: Tsay
authors: Hwei-Fang
authors: HF
authors: Tien
mesh_terms: D000368:Aged; D000782:Aneuploidy; D044466:Asian People / Q000706:statistics & numerical data; D001856:Bone Marrow Examination / Q000379:methods; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D015994:Incidence; D007399:Interphase; D053208:Kaplan-Meier Estimate; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013624:Taiwan / Q000453:epidemiology; D014314:Trisomy; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data