title: Determination of 6-thioguanine based on localized surface plasmon resonance of gold nanoparticle.
abstract: Gold nanoparticles exhibit the optical properties of localized surface plamon resonance (LSPR) and are widely applied to the biosensors. The application of gold nanoparticles to the determination of anticancer drug 6-thioguanine (6-TG) was discussed. The binding of 6-TG molecule to the surface of gold nanoparticles alters the local refractive index in the vicinity of the nanoparticles and results in a shift of the LSPR spectrum. The experimental conditions were examined and optimized. Under the optimal conditions, the ratios of absorbances at two wavelengths are directly proportional to the concentrations of 6-TG. The developed method is simple, rapid, and sensitive. In addition, this method is particularly attractive because organic cosolvents, light-sensitive dyes, and sophisticated instruments are not required. This method was successfully applied to the determination of 6-TG in real samples and the results were satisfactory.
authors: School of Physical and Chemical, Henan Polytechnic University, Jiaozuo 454000, PR China. bining@hpu.edu.cn
authors: Ning
authors: N
authors: Bi
authors: Meihua
authors: M
authors: Hu
authors: Hongyu
authors: H
authors: Zhu
authors: Haibo
authors: H
authors: Qi
authors: Yuan
authors: Y
authors: Tian
authors: Hanqi
authors: H
authors: Zhang
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000032:analysis* / Q000097:blood; D006041:Goats; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance / Q000191:economics / Q000379:methods*; D013866:Thioguanine / Q000032:analysis* / Q000097:blood
chemical_list: D000964:Antimetabolites, Antineoplastic; D004364:Pharmaceutical Preparations; D006046:Gold; D013866:Thioguanine