title: The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer.
abstract: Although some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of pAkt (Ser473) in 70 invasive breast cancers revealed that status of CerbB2 could play a major role in Akt phosphorylation, while ILK was also involved in the stimulated level of pAkt. The results would provide an important clue for the activation of Akt and potential targeted therapy in breast cancer.
authors: Department of Pathology, Health Science Center of Peking University, Beijing, China.
authors: Yingkai
authors: Y
authors: Chi
authors: Jing
authors: J
authors: Zhao
authors: Su-Ping
authors: SP
authors: Cui
authors: Ping
authors: P
authors: Jiang
authors: Hua-Li
authors: HL
authors: Wang
authors: Hong
authors: H
authors: Zhang
authors: Jing-Zhuo
authors: JZ
authors: Mao
authors: Hai-Jing
authors: HJ
authors: Liu
authors: Lin
authors: L
authors: Hou
authors: Bo
authors: B
authors: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051747:DNA-Activated Protein Kinase / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D009687:Nuclear Proteins / Q000378:metabolism; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies; D015398:Signal Transduction / Q000502:physiology; D000099200:Scaffold Protein ILK
chemical_list: D014408:Biomarkers, Tumor; D051747:DNA-Activated Protein Kinase; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D018719:Erb-b2 Receptor Tyrosine Kinases; D000099200:Scaffold Protein ILK; C497263:PRKDC protein, human