title: Use of Fourier-domain OCT to detect retinal nerve fiber layer degeneration in Parkinson's disease patients.
abstract: OBJECTIVE
  To demonstrate axonal loss in the retinal nerve fiber layer (RNFL) of patients with Parkinson's disease (PD) and to evaluate the ability of Fourier-domain optical coherence tomography (OCT) to detect RNFL degeneration and retinal thinning in these patients.
  
  
  METHODS
  PD patients (n=100) and healthy subjects (n=100) were included in the study and underwent visual acuity, color vision, and OCT examinations using two next-generation Fourier-domain devices (Spectralis and Cirrus). Differences in the RNFL thicknesses were compared between patients and controls.
  
  
  RESULTS
  RNFL thicknesses were significantly reduced in PD patients compared with healthy subjects, especially those obtained using the Spectralis OCT, in the inferotemporal quadrant (155.6±16.5 μm in healthy eyes vs 142.1±24.9 μm in patients, P=0.040) and in the superotemporal quadrant (142.6±20.9 μm in healthy eyes vs 132.77±18.6 μm in PD patients, P=0.046). Significant differences were observed between controls and patients in relation to mean macular thickness (P=0.031), foveal thickness (P=0.030), and inferior outer thickness (P=0.019).
  
  
  CONCLUSIONS
  PD is associated with RNFL loss and retinal thinning, which is detectable by Fourier-domain OCT measurements.
authors: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain.
authors: M
authors: M
authors: Satue
authors: E
authors: E
authors: Garcia-Martin
authors: I
authors: I
authors: Fuertes
authors: S
authors: S
authors: Otin
authors: R
authors: R
authors: Alarcia
authors: R
authors: R
authors: Herrero
authors: M P
authors: MP
authors: Bambo
authors: L E
authors: LE
authors: Pablo
authors: F J
authors: FJ
authors: Fernandez
mesh_terms: D000368:Aged; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology*; D012162:Retinal Degeneration / Q000175:diagnosis* / Q000473:pathology; D055351:Retinal Neurons / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*