title: Recommendations for pregnancies in patients with crigler-najjar syndrome.
abstract: During pregnancy, the developing foetus in mothers with Crigler-Najjar type 1 and 2 is exposed to raised levels of unconjugated bilirubin, with the risk of neurotoxicity. We describe two pregnancies in a patient with Crigler-Najjar type 2, who was carefully monitored prior to and during pregnancy and phototherapy adjusted to maintain serum bilirubin levels below 200 μmol/l and the bilirubin/albumin molar ratio below 50%. Both pregnancies resulted in normal delivery of healthy infants who had normal neurological development. A review of all reported pregnancies in Crigler-Najjar patients and a set of recommendations are presented.
authors: Department of Internal Medicine, Internal medicine, metabolic diseases Office D416 Erasmus MC, 2040, 3000 CA, Rotterdam, The Netherlands.
authors: J H Paul
authors: JH
authors: Wilson
authors: Maarten
authors: M
authors: Sinaasappel
authors: Fred K
authors: FK
authors: Lotgering
authors: Janneke G
authors: JG
authors: Langendonk