title: Matrix metalloproteinase-9, transforming growth factor-β1, and tumor necrosis factor-α plasma levels in chronic pancreatitis.
abstract: OBJECTIVE
  The aim of the study was to investigate the plasma levels of matrix metalloproteinase-9 (MMP-9), transforming growth factor-β 1 (TGF-β1), and tumor necrosis factor-α (TNF-α) in chronic pancreatitis (CP).
  
  
  METHODS
  Blood samples were obtained from 71 patients with CP and 100 control subjects, and plasma levels of MMP-9, TGF-β1, and TNF-α were determined by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The plasma levels of MMP-9 (18.3 ± 3.0 ng/mL, p < 0.0001), TGF-β1 (215.4 ± 178.1 ng/mL, p = 0.0301), and TNF-α (111.2 ± 69.3 ng/mL, p < 0.001) were significantly elevated in CP compared to the control group.
  
  
  CONCLUSIONS
  The role of elevated plasma MMP-9, TGF-β1, and TNF-α in CP requires further evaluation.
authors: Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500 016, India.
authors: K Sri
authors: KS
authors: Manjari
authors: A
authors: A
authors: Jyothy
authors: A
authors: A
authors: Vidyasagar
authors: B
authors: B
authors: Prabhakar
authors: Prathibha
authors: P
authors: Nallari
authors: A
authors: A
authors: Venkateshwari
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D050500:Pancreatitis, Chronic / Q000097:blood*; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D020780:Matrix Metalloproteinase 9