title: An evaluation of the effect of age and the peri-parturient period on bone metabolism in dairy cows as measured by serum bone-specific alkaline phosphatase activity and urinary deoxypyridinoline concentration.
abstract: Various biochemical markers help to evaluate the state of bone turnover in humans and could be used during the peri-parturient period in dairy cows when calcium (Ca) metabolism changes dramatically. To investigate this, the peri-partum characteristics of serum bone-specific alkaline phosphatase (BAP) and urinary deoxypyridinoline (DPD) were investigated. Both serum BAP activity and urinary DPD concentrations were increased and demonstrated wide variability in younger animals, and these findings were consistent with other bone turnover markers. Around the time of parturition, serum Ca concentration and serum BAP activity in multiparous cows were significantly lower than in primiparous cows, but urinary DPD concentration was unchanged. The use of BAP as a bone formation marker appears to be valuable for evaluating bone remodelling status in cows, but the specificity of the test needs to be confirmed. The DPD/BAP ratio around parturition demonstrated a clear difference in bone turnover status between the two parity groups with multiparous cows demonstrating increased signs of bone resorption compared with primiparous cows, corresponding to the Ca requirement for milk production. In future studies, the applicability of the ratio of bone resorption marker to bone formation marker should be evaluated for bone turnover assessment.
authors: Laboratory of Internal Medicine 3, Azabu University, School of Veterinary Medicine, 17-71 Fuchinobe 1-chome, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
authors: Reiichiro
authors: R
authors: Sato
authors: Ken
authors: K
authors: Onda
authors: Hajime
authors: H
authors: Kato
authors: Hideharu
authors: H
authors: Ochiai
authors: Kazuhiro
authors: K
authors: Kawai
authors: Tsunenori
authors: T
authors: Iriki
authors: Kazuyuki
authors: K
authors: Kaneko
authors: Yukio
authors: Y
authors: Yamazaki
authors: Yasunori
authors: Y
authors: Wada
mesh_terms: D000375:Aging; D000469:Alkaline Phosphatase / Q000235:genetics / Q000378:metabolism*; D000596:Amino Acids / Q000652:urine*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002417:Cattle / Q000502:physiology*; D005260:Female; D058725:Peripartum Period / Q000502:physiology*
chemical_list: D000596:Amino Acids; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase
keywords: Age; Bone-specific alkaline phosphatase; Dairy cow; Deoxypyridinoline; Hypocalcaemia