title: Factors affecting drug adsorption on beta zeolites.
abstract: The adsorption behaviour of three commonly used drugs, namely ketoprofen, hydrochlorothiazide and atenolol, from diluted aqueous solutions on beta zeolites with different SiO2/Al2O3 ratio (i.e. 25, 38 and 360) was investigated by changing the ionic strength and the pH, before and after thermal treatment of the adsorbents. The selective adsorption of drugs was confirmed by thermogravimetry and X-ray diffraction. The adsorption capacity of beta zeolites was strongly dependent on both the solution pH and the alumina content of the adsorbent. Such a remarkable difference was interpreted as a function of the interactions between drug molecules and zeolite surface functional groups. Atenolol was readily adsorbed on the less hydrophobic zeolite, under pH conditions in which electrostatic interactions were predominant. On the other hand, ketoprofen adsorption was mainly driven by hydrophobic interactions. For undissociated molecules the adsorption capability increased with the increase of hydrophobicity.
authors: Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy. luisa.pasti@unife.it
authors: Luisa
authors: L
authors: Pasti
authors: Elena
authors: E
authors: Sarti
authors: Alberto
authors: A
authors: Cavazzini
authors: Nicola
authors: N
authors: Marchetti
authors: Francesco
authors: F
authors: Dondi
authors: Annalisa
authors: A
authors: Martucci
mesh_terms: D000327:Adsorption; D001262:Atenolol / Q000737:chemistry*; D006852:Hydrochlorothiazide / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007660:Ketoprofen / Q000737:chemistry*; D009994:Osmolar Concentration; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D017641:Zeolites / Q000737:chemistry*
chemical_list: D006852:Hydrochlorothiazide; D017641:Zeolites; D001262:Atenolol; D007660:Ketoprofen