title: Computational design of novel protein binders and experimental affinity maturation.
abstract: Computational design of novel protein binders has recently emerged as a useful technique to study biomolecular recognition and generate molecules for use in biotechnology, research, and biomedicine. Current limitations in computational design methodology have led to the adoption of high-throughput screening and affinity maturation techniques to diagnose modeling inaccuracies and generate high activity binders. Here, we scrutinize this combination of computational and experimental aspects and propose areas for future methodological improvements.
authors: Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan, USA. taw@msu.edu
authors: Timothy A
authors: TA
authors: Whitehead
authors: David
authors: D
authors: Baker
authors: Sarel J
authors: SJ
authors: Fleishman
mesh_terms: D019295:Computational Biology / Q000379:methods*; D011485:Protein Binding; D011506:Proteins
chemical_list: D011506:Proteins