title: Reconstruction of defects in 11 patients with penile Paget's diseases with split-thickness skin graft.
abstract: BACKGROUND
  Extramammary Paget's disease (EMPD) is considered an intraepithelial adenocarcinoma. Paget's disease of the penis is the most common disease of EMPD in male patients.
  
  
  OBJECTIVE
  The objective of this study was to investigate and improve our knowledge of the clinical features, diagnosis, therapeutic methods and outcome of penile Paget's disease.
  
  
  METHODS
  Eleven patients from 2007 to 2012 with Paget's disease of the penis were analyzed retrospectively based on diagnosis, treatment and the results on follow-up. All patients received local expanding resection with intraoperative frozen sections and reconstruction of defects with split-thickness skin graft from autologous thigh tissue.
  
  
  RESULTS
  All surgeries were successful, and the postoperative course was uneventful with complete wound healing and graft survival. No lymph node metastasis was obtained. Both the morphology of the penis and its function were well maintained.
  
  
  CONCLUSIONS
  Chronic skin lesions of the penis should be biopsied as soon as possible, if they are suspected to be due to Paget's disease. Paget's disease of the penis should be treated with wide local excision and intraoperative frozen section examination. In addition, reconstruction of defects with split-thickness skin graft from the patient's thigh is an ideal choice for treatment.
authors: Department of Dermatology, Jiangsu Province Geriatric Hospital, 65 Jiangsu Road, Nanjing 210024, China.
authors: Xiao Yun
authors: XY
authors: Xu
authors: Ning
authors: N
authors: Shao
authors: Di
authors: D
authors: Qiao
authors: Quan
authors: Q
authors: Li
authors: Chang Jun
authors: CJ
authors: Yin
authors: Li Xin
authors: LX
authors: Hua
authors: Yi
authors: Y
authors: Ding
authors: Ning Hong
authors: NH
authors: Song
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000601:surgery*; D010412:Penile Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D016038:Skin Transplantation / Q000379:methods; D013521:Urologic Surgical Procedures, Male / Q000379:methods