title: Hot topic: investigating the risk of violative meat residues in bob veal calves fed colostrum from cows treated at dry-off with cephapirin benzathine.
abstract: The objective was to conduct a study to investigate if violative meat residues are detected in very young bob veal calves that are fed first-milking colostrum harvested from cows that were dry treated, on-label, with cephapirin benzathine. First-milking colostrum was collected from cows that were given intramammary treatment at dry off, on-label, with cephapirin benzathine (ToMORROW, Boehringer Ingelheim Vetmedica Inc., St. Joseph, MO). Newborn bull calves meeting study inclusion criteria were removed from their dams shortly after birth and before suckling, and assigned to 1 of 2 trials. For the first trial, 6 treated calves were fed 3.8L of fresh maternal colostrum and 1 control calf was fed 1.5 doses of a plasma-derived colostrum replacer (Secure Calf Colostrum Replacer, VitaPlus Inc., Madison, WI) within 1h after birth. For the second trial, 5 treated calves were fed 3.8L of fresh maternal colostrum and 1 control calf was fed 1.5 doses of Secure Calf Colostrum Replacer within 1h after birth. All calves were humanely euthanized at 24h (trial 1) or 48h (trial 2) of age, and tissues were harvested for antimicrobial residue testing. Samples of maternal colostrum and colostrum replacer were also submitted for antimicrobial residue testing. Kidneys collected from all study calves tested negative for cephapirin benzathine residues when using both the KIS assay (Charm Sciences, Lawrence, MA) and liquid chromatography-tandem mass spectrometry analysis. The potential transfer of cephapirin from cows treated on-label at dry off to calves via colostrum may not be a significant source of cephapirin residues in veal tissues.
authors: Department of Veterinary Population Medicine, University of Minnesota, St. Paul 55108.
authors: K
authors: K
authors: Hausler
authors: Department of Veterinary Population Medicine, University of Minnesota, St. Paul 55108. Electronic address: godde002@umn.edu.
authors: S M
authors: SM
authors: Godden
authors: US Department of Agriculture-Agricultural Research Service, Eastern Regional Research Center, Wyndmoor, PA 19038.
authors: M J
authors: MJ
authors: Schneider
authors: US Department of Agriculture-Agricultural Research Service, Eastern Regional Research Center, Wyndmoor, PA 19038.
authors: A R
authors: AR
authors: Lightfield
authors: DQCI Services, Mounds View, MN 55112.
authors: M
authors: M
authors: Bulthaus
authors: Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada.
authors: D
authors: D
authors: Haines
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis*; D002417:Cattle; D002514:Cephapirin / Q000008:administration & dosage / Q000032:analysis*; D003126:Colostrum / Q000737:chemistry*; D004032:Diet / Q000662:veterinary*; D004350:Drug Residues / Q000032:analysis; D005029:Ethylenediamines / Q000032:analysis; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D007668:Kidney / Q000737:chemistry; D008321:Mammary Glands, Animal / Q000187:drug effects; D008460:Meat / Q000032:analysis*
chemical_list: D000900:Anti-Bacterial Agents; D005029:Ethylenediamines; D002514:Cephapirin; C010044:benzathine