title: Reducing infectivity of HIV upon exposure to surfaces coated with N,N-dodecyl, methyl-polyethylenimine.
abstract: The infectivity of high-titer, cell-free HIV in culture media and human milk is rapidly reduced upon exposure to polyethylene slides painted with the linear hydrophobic polycation N,N-dodecyl,methyl-polyethylenimine (DMPEI). Accompanying viral p24 protein and free viral RNA analysis of solutions exposed to DMPEI-coated surfaces suggests that virion attachment to the polycationic surface and its subsequent inactivation are the likely mechanism of this phenomenon.
authors: Department of Chemical Engineering and Biotechnology, BioScience Engineering Research Group, University of Cambridge, New Museums Site, Pembroke Street, Cambridge CB2 3RA, UK. stephen.gerrard@cantab.net
authors: Stephen E
authors: SE
authors: Gerrard
authors: Alyssa M
authors: AM
authors: Larson
authors: Alexander M
authors: AM
authors: Klibanov
authors: Nigel K H
authors: NK
authors: Slater
authors: Carl V
authors: CV
authors: Hanson
authors: Barbara F
authors: BF
authors: Abrams
authors: Mary K
authors: MK
authors: Morris
mesh_terms: D004202:Disinfectants / Q000494:pharmacology*; D004783:Environmental Microbiology; D004864:Equipment and Supplies / Q000821:virology*; D006678:HIV / Q000187:drug effects*; D006801:Humans; D050296:Microbial Viability / Q000187:drug effects; D011094:Polyethyleneimine / Q000031:analogs & derivatives* / Q000494:pharmacology; D019562:Viral Load
chemical_list: D004202:Disinfectants; C525941:N,N-dodecyl,methyl-polyethylenimine; D011094:Polyethyleneimine