title: Absence of Pneumocystis dihydropteroate synthase mutants in Brittany, France.
abstract: Archival Pneumocystis jirovecii specimens from 84 patients monitored at Rennes University Hospital (Rennes, France) were assayed at the dihydropteroate synthase (DHPS) locus. No patient was infected with mutants. The results provide additional data showing that P. jirovecii infections involving DHPS mutants do not represent a public health issue in Brittany, western France.
authors: University of Brest, LUBEM EA 3882, SFR 148, Brest, France; Laboratory of Parasitology and Mycology, Brest University Hospital, Brest, France. solene.legal@chu-brest.fr
authors: Solène
authors: S
authors: Le Gal
authors: Florence
authors: F
authors: Robert-Gangneux
authors: Maëla
authors: M
authors: Perrot
authors: Amélie
authors: A
authors: Rouillé
authors: Michèle
authors: M
authors: Virmaux
authors: Céline
authors: C
authors: Damiani
authors: Anne
authors: A
authors: Totet
authors: Jean-Pierre
authors: JP
authors: Gangneux
authors: Gilles
authors: G
authors: Nevez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018893:Bronchoalveolar Lavage; D004271:DNA, Fungal / Q000235:genetics; D004094:Dihydropteroate Synthase / Q000235:genetics*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D045363:Pneumocystis carinii / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D013048:Specimen Handling; D013449:Sulfonamides / Q000627:therapeutic use
chemical_list: D004271:DNA, Fungal; D013449:Sulfonamides; D004094:Dihydropteroate Synthase