title: Multifocal diffusion of a KPC-3 producing ST512 K. pneumoniae clone in Northern Italy.
abstract: Sequence Type 258 (ST258) together with its allelic single- and double-locus variants have mostly been associated with the dissemination of KPC-producing Klebsiella pneumoniae in Europe. A total of 56 nonreplicate K. pneumoniae isolates with decreased carbapenem-susceptibility, collected at 7 different hospitals located in Northern Italy were investigated for the occurrence of blaKPC-type genes. PCR and sequencing results highlighted the presence of blaKPC2 or blaKPC-3 determinants in 10/56 and 5/56 cases respectively. Here we describe the intra- and inter-hospital spread in Northern Italy of a K. pneumoniae ST512 clone harboring the blaKPC-3 gene.
authors: Department of Clinical Surgical Diagnostic and Paediatric Sciences, University of Pavia, Italy. r.miglia@unipv.it
authors: Roberta
authors: R
authors: Migliavacca
authors: Elisabetta
authors: E
authors: Nucleo
authors: Sara
authors: S
authors: Asticcioli
authors: Erminia
authors: E
authors: Casari
authors: Silvia
authors: S
authors: Bracco
authors: Maria C
authors: MC
authors: Sironi
mesh_terms: D015373:Bacterial Typing Techniques; D002999:Clone Cells; D003428:Cross Infection / Q000382:microbiology* / Q000635:transmission; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007710:Klebsiella Infections / Q000188:drug therapy / Q000382:microbiology* / Q000635:transmission; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D001618:beta-Lactamases