title: Estrogen and estrogen receptors in cardiovascular oxidative stress.
abstract: The cardiovascular system of a premenopausal woman is prepared to adapt to the challenges of increased cardiac output and work load that accompany pregnancy. Thus, it is tempting to speculate whether enhanced adaptability of the female cardiovascular system might be advantageous under conditions that promote cardiovascular disease. In support of this concept, 17β-estradiol as the major female sex hormone has been shown to confer protective cardiovascular effects in experimental studies. Mechanistically, these have been partially linked to the prevention and protection against oxidative stress. Current evidence indicates that estrogens attenuate oxidative stress at two levels: first, by preventing generation of reactive oxygen species (ROS) and, second, by scavenging ROS in the myocardium and in the vasculature. The purpose of this review is to give an overview on current concepts on conditions and mechanisms by which estrogens protect the cardiovascular system against ROS-mediated cellular injury.
authors: Department of Internal Medicine I, University Hospital of Würzburg, Würzburg, Germany.
authors: Paula-Anahi
authors: PA
authors: Arias-Loza
authors: Melanie
authors: M
authors: Muehlfelder
authors: Theo
authors: T
authors: Pelzer
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen