title: Analyses of radiation and mesothelioma in the US Transuranium and Uranium Registries.
abstract: OBJECTIVE
  We examined the relationship between radiation and excess deaths from mesothelioma among deceased nuclear workers who were part of the US Transuranium and Uranium Registries.
  
  
  METHODS
  We performed univariate analysis with SAS Version 9.1 software. We conducted proportionate mortality ratio (PMR) and proportionate cancer mortality ratio (PCMR) analyses using the National Institute for Occupational Safety and Health Life Table Analysis System with the referent group being all deaths in the United States.
  
  
  RESULTS
  We found a PMR of 62.40 (P < .05) and a PCMR of 46.92 (P < .05) for mesothelioma. PMRs for the 4 cumulative external radiation dose quartiles were 61.83, 57.43, 74.46, and 83.31. PCMRs were 36.16, 47.07, 51.35, and 67.73. The PMR and PCMR for trachea, bronchus, and lung cancer were not significantly elevated.
  
  
  CONCLUSIONS
  The relationship between cumulative external radiation dose and the PMR and PCMR for mesothelioma suggests that external radiation at nuclear facilities is associated with an increased risk of mesothelioma. The lack of a significantly elevated PMR and PCMR for trachea, bronchus, and lung cancer suggests that asbestos did not confound this relationship.
authors: Tetra Tech Sciences, Arlington, VA 22201, USA. Herman.Gibb@tetratech.com
authors: Herman
authors: H
authors: Gibb
authors: Keri
authors: K
authors: Fulcher
authors: Sumitha
authors: S
authors: Nagarajan
authors: Stacey
authors: S
authors: McCord
authors: Naz Afarin
authors: NA
authors: Fallahian
authors: Heather J
authors: HJ
authors: Hoffman
authors: Cary
authors: C
authors: Haver
authors: Sergei
authors: S
authors: Tolmachev
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D016009:Chi-Square Distribution; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality*; D008297:Male; D008654:Mesothelioma / Q000401:mortality*; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000401:mortality*; D009784:Occupational Diseases / Q000401:mortality*; D011829:Radiation Dosage; D011874:Radiometry; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D014501:Uranium
chemical_list: D014501:Uranium