title: Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study.
abstract: We investigated volume and shape changes in the striatum (caudate, putamen, and nucleus accumbens) of 18 early-onset (EOAD) and 18 late-onset (LOAD) Alzheimer's Disease patients compared with 2 control groups age- and sex-matched to each patient group, and explored the relationship between striatal atrophy and apolipoprotein E (APOE) genotype. EOAD patients showed significant shape changes in the left and right ventral putamen (p < 0.05, corrected for multiple comparison with permutation tests). LOAD patients showed significant reductions in the left and right nucleus accumbens volumes (p < 0.05; Mann-Whitney test) and shape (p < 0.05; permutation test). Caudate abnormalities were detected in EOAD and LOAD patients in terms of local enlargements and reductions (p < 0.05 for the left and right, permutation test). When APOE was considered, significant differences were detected between LOAD ε4 carriers and noncarriers in the left and right caudate (p < 0.05, permutation test). These results suggest distinct patterns of striatal pathology in EOAD and LOAD patients, the dorsal striatum being involved in EOAD and the ventral striatum in LOAD.
authors: Laboratory of Epidemiology, Neuroimaging and Telemedicine-LENITEM, IRCCS Istituto Centro San Giovanni di Dio, Fatebenefratelli, Brescia, Italy.
authors: Michela
authors: M
authors: Pievani
authors: Martina
authors: M
authors: Bocchetta
authors: Marina
authors: M
authors: Boccardi
authors: Enrica
authors: E
authors: Cavedo
authors: Matteo
authors: M
authors: Bonetti
authors: Paul M
authors: PM
authors: Thompson
authors: Giovanni B
authors: GB
authors: Frisoni
mesh_terms: D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D001057:Apolipoproteins E / Q000235:genetics; D003342:Corpus Striatum / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged
chemical_list: D001057:Apolipoproteins E