title: Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma.
abstract: The objective of this study was to evaluate the potential detection of circulating tumor cells (CTCs) using the CellSearch (CS) Assay™ in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) and then to identify the clinical factors predictive of the presence of CTCs. The presence and number of CTCs were determined using the CS system before treatment, and in 10 healthy individuals (control group). The CS system was able to successfully identify the presence of CTCs in 8 of 49 patients (16 %) before therapy. No CTC was found in the control group. CTCs were detected before therapy in 1 of 19 patients (5 %) with N0 tumor and in 7 of 30 patients (23 %) with N1-2c tumor (p = 0.12; Fisher's exact test). CTCs were identified in a relatively low proportion of patients with locally advanced HNSCC.
authors: Department of Surgery, Institut Universitaire de la Face et du Cou, 31 Avenue de Valombrose, 06103 Nice, France. alexandre.bozec@nice.unicancer.fr
authors: Alexandre
authors: A
authors: Bozec
authors: Marius
authors: M
authors: Ilie
authors: Olivier
authors: O
authors: Dassonville
authors: Elodie
authors: E
authors: Long
authors: Gilles
authors: G
authors: Poissonnet
authors: José
authors: J
authors: Santini
authors: Emmanuel
authors: E
authors: Chamorey
authors: Marc
authors: M
authors: Ettaiche
authors: Damien
authors: D
authors: Chauvière
authors: Frédéric
authors: F
authors: Peyrade
authors: Christophe
authors: C
authors: Hebert
authors: Karen
authors: K
authors: Benezery
authors: Anne
authors: A
authors: Sudaka
authors: Juliette
authors: J
authors: Haudebourg
authors: Eric
authors: E
authors: Selva
authors: Paul
authors: P
authors: Hofman
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002452:Cell Count; D000071858:Epithelial Cell Adhesion Molecule; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000378:metabolism*; D009959:Oropharyngeal Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C499379:EPCAM protein, human; D000071858:Epithelial Cell Adhesion Molecule; D007633:Keratins