title: Macromolecular prodrugs of ribavirin combat side effects and toxicity with no loss of activity of the drug.
abstract: Chemi-enzymatic synthesis of ribavirin acrylate and subsequent RAFT co-polymerization with acrylic acid afforded a formulation of a broad spectrum antiviral drug which avoids accumulation in erythrocytes, the origin of the main side effect of ribavirin. In cultured macrophages the macromolecular prodrugs exhibited decreased toxicity while maintaining the anti-inflammatory action of ribavirin.
authors: Interdisciplinary Nanoscience Centre (iNANO), The iNANO House, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark.
authors: Mille B L
authors: MB
authors: Kryger
authors: Benjamin M
authors: BM
authors: Wohl
authors: Anton A A
authors: AA
authors: Smith
authors: Alexander N
authors: AN
authors: Zelikin
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012254:Ribavirin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000179:Acrylates; D046911:Macromolecular Substances; D011355:Prodrugs; D009569:Nitric Oxide; D012254:Ribavirin; C036658:acrylic acid