title: An emerging role for microRNA in the regulation of endothelin-1.
abstract: Endothelin-1 (ET-1) is a peptide signaling molecule serving diverse functions in many different tissues such as the vasculature and the kidney. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (EDN1), but recent research suggests that EDN1 expression is attenuated by microRNA (miRNA)-mediated regulation. The action of specific miRNAs on EDN1 mRNA appears to vary greatly in a tissue specific manner. This review provides a summary of our current understanding of miRNA-EDN1 interaction.
authors: Cain Laboratory, Department of Biochemistry and Molecular Biology, University of Florida Gainesville, FL, USA.
authors: Mollie E
authors: ME
authors: Jacobs
authors: Charles S
authors: CS
authors: Wingo
authors: Brian D
authors: BD
authors: Cain
keywords: EDN1 mRNA; ET-1; endothelin signaling; endothelin-1; microRNA