title: Meta-analysis demonstrates  association  between TLR polymorphisms and  rheumatoid arthritis.
abstract: We  investigated whether Toll-like receptor (TLR) polymorphisms confer  susceptibility to rheumatoid arthritis and whether they influence clinical  characteristics of rheumatoid arthritis. Studies were considered relevant for  our meta-analysis if at least two comparisons of an issue were available.  Eleven studies with 2078 patients with rheumatoid arthritis and 2581 controls were  included, encompassing European and Asian studies. Meta-analysis of three  European studies showed no significant association between the TLR4 Asp299Gly  (rs4986790) polymorphism and rheumatoid arthritis (odds ratio = 0.897, 95%  confidence interval = 0.734-1.096, P = 0.289). One Turkish study showed a  significant difference between TLR9 rs187084 allele frequencies and  rheumatoid arthritis patients and controls, while another study revealed a  significant association between rheumatoid factor and TLR8 rs5741883. A  Korean study on the numbers of guanine-thymine [(GT)(n)] repeats in  intron II of the TLR2 gene found a significantly higher S-allele  frequency in rheumatoid arthritis patients than in controls (30.3 vs 23.0%).  Overall findings for the meta-analysis including all the studies conclude that TLR polymorphism is associated with development and clinical characteristics of  rheumatoid arthritis in Asian and Middle East populations.
authors: Division of Rheumatology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. lyhcgh@korea.ac.kr
authors: Y H
authors: YH
authors: Lee
authors: S-C
authors: SC
authors: Bae
authors: G G
authors: GG
authors: Song
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns; D008297:Male; D011110:Polymorphism, Genetic; D051193:Toll-Like Receptors / Q000235:genetics*
chemical_list: D051193:Toll-Like Receptors