title: Low-grade cribriform cystadenocarcinoma of salivary glands: report of two cases and review of the literature.
abstract: Low-grade cribriform cystadenocarcinoma (LGCCC) is a recently described rare tumor of salivary gland which exhibits clinically indolent behavior. This tumor predominantly consists of intraductal components and frequently exhibits papillary-cystic or cribriform proliferation pattern. Considering the histological features of LGCCC, it should be distinguished with papillocystic variant of acinic cell carcinoma, conventional salivary duct carcinoma, cystadenocarcinoma, polymorphous low-grade adenocarcinoma, carcinoma ex pleomorphic adenoma and mammary analogue secretory carcinoma. Herein, we presented two cases of LGCCC. One arose in the left parotid region in a 48-year-old male, and the other one arose in the right parotid gland in a 59-year-old female. For both cases, immunohistochemically, the luminal tumor cells showed diffuse expression of CK and S100; p63 and smooth muscle actin displayed a continuous rim of myoepithelial cells around all tumor islets; no myoepithelial cells were admixed with the luminal cells. Both patients were alive with no tumor recurrence or metastasis at follow-up.
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authors: Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China. wangeh775@gmail.com
authors: Liang
authors: L
authors: Wang
authors: Yang
authors: Y
authors: Liu
authors: Xuyong
authors: X
authors: Lin
authors: Di
authors: D
authors: Zhang
authors: Qingchang
authors: Q
authors: Li
authors: Xueshan
authors: X
authors: Qiu
authors: En-Hua
authors: EH
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D003536:Cystadenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010307:Parotid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests
chemical_list: D014408:Biomarkers, Tumor