title: Clinical Characteristics of Patients with Autoimmune Pancreatitis with or without Mikulicz's Disease and Mikulicz's Disease Alone.
abstract: OBJECTIVE
  The objective of this study was to compare the clinical characteristics of patients with autoimmune pancreatitis (AIP) with or without Mikulicz's disease (MD) and with MD alone.
  
  
  METHODS
  We investigated the clinical findings in 15 AIP patients with MD (group A+M), 49 AIP only patients (group A), and 14 MD only patients (group M).
  
  
  RESULTS
  The male-female ratio was significantly higher in group A+M (73%, p<0.05) and group A (78%, p<0.01) than group M (21%). Serum immunoglobulin G (IgG) levels were significantly higher in group A+M than in group A (p<0.01) and group M (p<0.05). Serum IgG4 levels were significantly higher in group A+M than in group A (p<0.01). Other organ involvement was observed in 73% (11/15) of patients in group A+M. The number of patients with diabetes mellitus was significantly higher in group A+M (66%, p<0.01) and group A (51%, p<0.05) than in group M (7%). All of the patients responded well to steroid therapy, but the relapse rate in group A+M (33%) was significantly higher than that in group A (3%, p<0.01). Salivary gland function was impaired in all groups compared with the control group, but the degree of dysfunction was less in group A compared with group A+M and group M.
  
  
  CONCLUSIONS
  The relapse rate of AIP in MD patients was significantly higher than that of AIP in patients without MD.
authors: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Sawako
authors: S
authors: Kuruma
authors: Terumi
authors: T
authors: Kamisawa
authors: Taku
authors: T
authors: Tabata
authors: Seiichi
authors: S
authors: Hara
authors: Takashi
authors: T
authors: Fujiwara
authors: Go
authors: G
authors: Kuwata
authors: Hideto
authors: H
authors: Egarashira
authors: Koichi
authors: K
authors: Koizumi
authors: Keigo
authors: K
authors: Setoguchi
authors: Junko
authors: J
authors: Fujiwara
authors: Takeo
authors: T
authors: Arakawa
authors: Kumiko
authors: K
authors: Momma
authors: Toshio
authors: T
authors: Mitsuhashi
authors: Tsuneo
authors: T
authors: Sasaki
keywords: Autoimmune pancreatitis; IgG4-related disease; Immunoglobulin G; Mikulicz' disease; Steroid therapy