title: Course of the type of patient who is candidate for radical prostatectomy over 2 decades (1989-2009).
abstract: OBJECTIVE
  To know the changes experienced by the patient profile candidate for radical prostatectomy over the last 2 decades in our institution..
  
  
  METHODS
  We analyze retrospectively a series of 1.132 patients with prostate cancer stadium T1-T2, submitted to radical prostatectomy during the period 1989-2009. The series divides in five homogeneous groups as for the number of patients and arranged chronologically. There uses the free survival of biochemical progression (SLPB) as criterion principal forecast.
  
  
  RESULTS
  In spite of the changes in the diagnosis and treatment of the disease, from the point of view of the forecast (SLPB) we estimate two groups different from patients: the first 250 controlled ones and the rest. The point of chronological cut places in this series in 1.999. We find significant differences in the majority of the clinical-pathological variables as PSA's level to the diagnosis (P <0,001), percentage of palpable tumors (P <0,001), clinical stadium (P <0,001), Gleason in the prostate biopsy (P =0,004), groups at risk of D'Amico (P <0,001), pathological stage (P <0,001), and percentage of patients with lymph node (P <0,001). Nevertheless, there are not detected differences of statistical significance in the Gleason of the specimen of prostatectomy (P =0,06) and in the percentage of surgical margins (P =0,6).
  
  
  CONCLUSIONS
  This study analyzes a patients' wide proceeding sample from the whole Spanish geography and presents some important information that reflect the evolution that has suffered the cancer of prostate located, so much regarding the diagnosis as to the forecast, in our country in the last 20 years.
authors: Departamento de Urología, Clínica Universidad de Navarra, Pamplona, España. Electronic address: ralgarra@unav.es.
authors: R
authors: R
authors: Algarra
authors: J
authors: J
authors: Zudaire
authors: D
authors: D
authors: Rosell
authors: J E
authors: JE
authors: Robles
authors: J M
authors: JM
authors: Berián
authors: I
authors: I
authors: Pascual
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000145:classification / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D000368:Aged; D001706:Biopsy; D018450:Disease Progression; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010173:Palpation; D011183:Postoperative Complications / Q000453:epidemiology; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000379:methods / Q000639:trends; D011471:Prostatic Neoplasms / Q000097:blood / Q000145:classification / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D013030:Spain / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen