title: Non-invasive embolus trap using histotripsy-an acoustic parameter study.
abstract: Free-flowing particles in a blood vessel were observed to be attracted, trapped and eroded by a histotripsy bubble cloud. This phenomenon may be used to develop a non-invasive embolus trap (NET) to prevent embolization. This study investigates the effect of acoustic parameters on the trapping ability of the NET generated by a focused 1.063 MHz transducer. The maximum trapping velocity, defined by the maximum mean fluid velocity at which a 3-4 mm particle trapped in a 6 mm diameter vessel phantom, increased linearly with peak negative pressure (P-) and increased as the square root of pulse length and pulse repetition frequency (PRF). At 19.9 MPa P-, 1000 Hz PRF and 10 cycle pulse length, a 3 mm clot-mimicking particle could remain trapped under a background velocity of 9.7 cm/s. Clot fragments treated by NET resulted in debris particles <75 μm. These results will guide the appropriate selection of NET parameters.
authors: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors: Simone
authors: S
authors: Park
authors: Adam D
authors: AD
authors: Maxwell
authors: Gabe E
authors: GE
authors: Owens
authors: Hitinder S
authors: HS
authors: Gurm
authors: Charles A
authors: CA
authors: Cain
authors: Zhen
authors: Z
authors: Xu
mesh_terms: D032701:Biomimetics / Q000379:methods; D004617:Embolism / Q000503:physiopathology* / Q000517:prevention & control*; D006801:Humans; D008096:Lithotripsy / Q000379:methods*; D061185:Mechanical Thrombolysis / Q000379:methods*