title: The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer.
abstract: Among the secretory phospholipase A2s (sPLA2), sPLA2 group X (PLA2GX) has the most potent hydrolyzing activity toward phosphatidylcholine, and has recently been shown to be implicated in chronic inflammatory diseases. The aim of the present study was to investigate PLA2GX expression in colorectal cancer (CRC) and its correlation with patient clinicopathological features. The present study comprises a series of 158 patients who underwent surgical resection for primary CRC. PLA2GX expression in CRC tissues was examined by immunohistochemistry and compared with patient clinicopathological findings and survival. A total of 64% of the tumors expressed PLA2GX at high levels. Statistical analysis revealed that PLA2GX expression was inversely correlated with hematogenous metastasis (P=0.005). In the subgroup analysis, left-sided tumors with high PLA2GX expression showed an inverse correlation with lymph node metastasis (P=0.018) and hematogenous metastasis (P=0.017). Patients with high PLA2GX expression tended to have a longer disease-specific survival compared with those with low PLA2GX expression in left-sided, but not right-sided, CRC (P=0.08). In light of the present results, we suggest that PLA2GX has an inhibitory effect on the progression of CRC.
authors: Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655;
authors: Masaya
authors: M
authors: Hiyoshi
authors: Joji
authors: J
authors: Kitayama
authors: Shinsuke
authors: S
authors: Kazama
authors: Yoshitaka
authors: Y
authors: Taketomi
authors: Makoto
authors: M
authors: Murakami
authors: Nelson H
authors: NH
authors: Tsuno
authors: Kumiko
authors: K
authors: Hongo
authors: Manabu
authors: M
authors: Kaneko
authors: Eiji
authors: E
authors: Sunami
authors: Toshiaki
authors: T
authors: Watanabe
keywords: colorectal cancer; immunohistochemistry; metastasis; phospholipase A2