title: Acrylamide hemoglobin adduct levels and ovarian cancer risk: a nested case-control study.
abstract: BACKGROUND
  Acrylamide is a probable human carcinogen formed during cooking of starchy foods. Two large prospective cohort studies of dietary acrylamide intake and ovarian cancer risk observed a positive association, although two other studies reported no association.
  
  
  METHODS
  We measured acrylamide exposure using red blood cell acrylamide and glycidamide hemoglobin adducts among women in two large prospective cohorts: the Nurses' Health Study and Nurses' Health Study II. Between blood collection and 2010, we identified 263 incident cases of epithelial ovarian cancer, matching two controls per case. We used logistic regression models to examine the association between acrylamide exposure and ovarian cancer risk, adjusting for matching factors, family history of ovarian cancer, tubal ligation, oral contraceptive use, body mass index, parity, alcohol intake, smoking, physical activity, and caffeine intake.
  
  
  RESULTS
  The multivariate-adjusted relative risk (RR) of ovarian cancer comparing the highest versus lowest tertile of total acrylamide adducts was 0.79 (95% CI, 0.50-1.24, P trend = 0.08). The comparable RR of ovarian cancer among non-smokers at blood draw was 0.85 (95% CI, 0.57-1.27, P trend = 0.14). The association did not differ by tumor histology (serous invasive versus not), P for heterogeneity = 0.86. Individual adduct types (acrylamide or glycidamide) were not associated with risk.
  
  
  CONCLUSIONS
  We observed no evidence that acrylamide exposure as measured by adducts to hemoglobin is associated with an increased risk of ovarian cancer.
  
  
  CONCLUSIONS
  Our finding indicates that acrylamide intake may not increase risk of ovarian cancer.
authors: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
authors: Jing
authors: J
authors: Xie
authors: Kathryn L
authors: KL
authors: Terry
authors: Elizabeth M
authors: EM
authors: Poole
authors: Kathryn M
authors: KM
authors: Wilson
authors: Bernard A
authors: BA
authors: Rosner
authors: Walter C
authors: WC
authors: Willett
authors: Hubert W
authors: HW
authors: Vesper
authors: Shelley S
authors: SS
authors: Tworoger
mesh_terms: D020106:Acrylamide / Q000009:adverse effects*; D000328:Adult; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D004852:Epoxy Compounds / Q000009:adverse effects; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000139:chemically induced* / Q000378:metabolism; D009726:Nurses; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D004852:Epoxy Compounds; D006454:Hemoglobins; D020106:Acrylamide; C071834:glycidamide