title: Prevention of recurrent episodes of rhabdomyolysis with tacrolimus in a transplant recipient with myopathy.
abstract: Genetic muscular disorders are known risk factors for rhabdomyolysis, which may result in acute kidney injury. Recurrent episodes of acute kidney injury can lead to chronic kidney disease and eventually end-stage renal failure. We describe a patient with chronic kidney disease that developed in the setting of recurrent rhabdomyolysis, resulting in the requirement for renal transplantation. After transplantation, the maintenance of tacrolimus trough concentrations above what is typically prescribed for standard renal transplant recipients appeared to confer protection from further episodes of rhabdomyolysis. This is consistent with previous case series that demonstrated a therapeutic benefit of the calcineurin inhibitor cyclosporine in collagen VI myopathies in the nontransplant population. This case report suggests the potential application of higher tacrolimus targets in patients who have undergone renal transplantation in the setting of recurrent rhabdomyolysis leading to end-stage renal failure.
authors: 1Division of Nephrology and Hypertension, New York Presbyterian Hospital-Weill Cornell, New York, NY; 2Department of Cardiology, New York Methodist Hospital, Brooklyn, NY; and 3The Rogosin Institute and The Weill Medical College of Cornell University, New York, NY.
authors: Sharad
authors: S
authors: Sathyan
authors: Rawya
authors: R
authors: Baskharoun
authors: Alan S
authors: AS
authors: Perlman
mesh_terms: D065095:Calcineurin Inhibitors / Q000627:therapeutic use*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000150:complications*; D012008:Recurrence; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000601:surgery*; D012206:Rhabdomyolysis / Q000517:prevention & control*; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D065095:Calcineurin Inhibitors; D016559:Tacrolimus