title: Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet.
abstract: Fetuin-A is synthesized in the liver and is secreted into the bloodstream. Clinical studies suggest involvement of fetuin-A in metabolic disorders such as visceral obesity, insulin resistance, diabetes, and fatty liver. Curcumin is extracted from the rhizome Curcuma longa and has been shown to possess potent antioxidant, anticarcinogenic, anti-inflammatory, and hypoglycemic properties. In this study, we investigated the effect of curcumin treatment on serum fetuin-A levels as well as hepatic lipids and prooxidant-antioxidant status in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were divided into six groups. Group 1 was fed control diet (10 % of total calories from fat). Groups 2 and 3 were given curcumin (100 and 400 mg/kg bw/day, respectively ) by gavage for 8 weeks and were fed control diet. Group 4 was fed with HFD (60 % of total calories from fat). Groups 5 and 6 received HFD together with the two doses of curcumin, respectively. Curcumin treatment appeared to be effective in reducing liver triglycerides and serum fetuin-A levels. These findings suggest that the reduction of fetuin-A may contribute to the beneficial effects of curcumin in the pathogenesis of obesity.
authors: Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, Istanbul, Turkey, iyidogan@istanbul.edu.tr.
authors: Yildiz
authors: Y
authors: Öner-İyidoğan
authors: Hikmet
authors: H
authors: Koçak
authors: Muhammed
authors: M
authors: Seyidhanoğlu
authors: Figen
authors: F
authors: Gürdöl
authors: Ahmet
authors: A
authors: Gülçubuk
authors: Funda
authors: F
authors: Yildirim
authors: Aydin
authors: A
authors: Çevik
authors: Müjdat
authors: M
authors: Uysal
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003474:Curcumin / Q000008:administration & dosage*; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000009:adverse effects; D004734:Energy Metabolism / Q000187:drug effects; D005234:Fatty Liver / Q000097:blood / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009765:Obesity / Q000097:blood / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D014280:Triglycerides; D060749:alpha-2-HS-Glycoprotein; D008315:Malondialdehyde; D002784:Cholesterol; D003474:Curcumin