title: Reading the tea leaves of tumor-mediated immunosuppression.
abstract: Polyphenol E, available as Polyphenon E, is a green tea extract whose activity can be benchmarked to the presence of specific catechins such as epigallocatechin 3-gallate (EGCG). Herein, Polyphenon E is shown to reverse myeloid-derived suppressor cell activity, linking the activity of a natural product extract to cell-mediated immunity.
authors: Pediatric Oncology Branch, National Cancer Institute, CCR, NIH, Bethesda, Maryland 20892, USA. Rimas.Orentas@nih.gov
authors: Rimas J
authors: RJ
authors: Orentas
mesh_terms: D000818:Animals; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007165:Immunosuppression Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology*; D018515:Plant Leaves / Q000737:chemistry*; D059808:Polyphenols / Q000494:pharmacology*; D013662:Tea
chemical_list: D059808:Polyphenols; D013662:Tea