title: The association of cardiac vagal control and executive functioning--findings from the MIDUS study.
abstract: Cardiac vagal control (CVC), an index of parasympathetic contribution to cardiac regulation, has been linked to enhanced executive functioning (EF). However, findings to date have been based on small or unique samples. Additionally, previous studies assessed the CVC-EF link only during rest or recovery period from a cognitive challenge, but not during both states. In the present study, data on 817 socioeconomically diverse participants were obtained from the Midlife Development in the United States (MIDUS) study. As part of this study, participants completed cognitive tests, including EF, along with laboratory-based measures of CVC during rest and following recovery from a cognitive challenge. Regression analyses adjusting for respiratory rate revealed no effect of CVC at rest or during recovery on a global index of EF. However, exploratory post-hoc analyses of the components of the global EF index revealed a significant association between faster vagal recovery and better attention-switching and response inhibition abilities, as indexed by faster reaction time to the mixed SGST. This association remained significant after controlling for demographic, clinical (BMI, diseases and medications altering cardiac autonomic functioning, etc.), and health behavior covariates (Beta = .148, p = .010). Our findings suggest that future studies may need to investigate the links of CVC to specific EF abilities, rather than global measures of EF. Additionally, our results highlight the importance of assessing CVC during both rest and recovery from a cognitive challenge. The authors discuss the putative neurobiological underpinning of this link, as well as suggestions for future basic and clinical research.
authors: Division of Cognitive Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA. kimhyda@nyspi.columbia.edu
authors: D
authors: D
authors: Kimhy
authors: O V
authors: OV
authors: Crowley
authors: P S
authors: PS
authors: McKinley
authors: M M
authors: MM
authors: Burg
authors: M E
authors: ME
authors: Lachman
authors: P A
authors: PA
authors: Tun
authors: C D
authors: CD
authors: Ryff
authors: T E
authors: TE
authors: Seeman
authors: R P
authors: RP
authors: Sloan
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001288:Attention; D004562:Electrocardiography; D056344:Executive Function / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D012146:Rest / Q000502:physiology; D014481:United States; D014630:Vagus Nerve / Q000502:physiology*; D014705:Verbal Behavior