title: Cryptococcus humicolus meningitis: first case report in Malaysia.
abstract: We report a case of Cryptococcus humicolus meningitis complicated by communicating hydrocephalus in an apparently immunocompetent 49-year-old psychiatric patient from a nursing home. He presented with a history of poor oral intake, weight loss, headache, vomiting, blurred vision, frequent falls and unsteady gait for the previous three months. He had a history of chronic cough, productive of whitish sputum for the previous month but no hemoptysis. Cerebrospinal fluid culture was positive for Cryptococcus humicolus. He was treated with intravenous amphotericin B and oral fluconazole and had clinical and microbiological improvement after three weeks of treatment. Unfortunately, the patient acquired nosocomial methicillin-resistant Staphylococcus aureus infection and died due to overwhelming sepsis.
authors: Department of Medical Microbiology and Immunology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. srosz77@gmail.com
authors: Siti Roszilawati
authors: SR
authors: Ramli
authors: Mooi Chin
authors: MC
authors: Leong
authors: Tzar Mohd Nizam
authors: TM
authors: Khaithir
authors: Muhammad Nazri
authors: MN
authors: Aziz
authors: Leong Chee
authors: LC
authors: Loons
authors: Md Hanip
authors: MH
authors: Rafia
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003454:Cryptococcus; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology* / Q000382:microbiology*; D007121:Immunocompetence; D008296:Malaysia; D008297:Male; D016921:Meningitis, Fungal / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole