title: Pharmacological actions of multi-target-directed evodiamine.
abstract: Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of Evodiae fructus. With respect to the pharmacological actions of evodiamine, more attention has been paid to beneficial effects in insults involving cancer, obesity, nociception, inflammation, cardiovascular diseases, Alzheimer's disease, infectious diseases and thermo-regulative effects. Evodiamine has evolved a superior ability to bind various proteins, so we also argue that it is good starting point for multi-target drugs. This review is primarily addressed to the description of the recent advances in the biological activity studies of evodiamine, with a focus on pharmacological mechanism. The present review also includes the pharmacokinetics and the detailed exploration of target-binding properties of evodiamine in an attempt to provide a direction for further multi-target drug design.
authors: State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
authors: Hui
authors: H
authors: Yu
authors: Hongwei
authors: H
authors: Jin
authors: Wuzhuang
authors: W
authors: Gong
authors: Zhanli
authors: Z
authors: Wang
authors: Huaping
authors: H
authors: Liang
mesh_terms: D000818:Animals; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D011506:Proteins / Q000378:metabolism; D011799:Quinazolines / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D008024:Ligands; D011506:Proteins; D011799:Quinazolines; C049639:evodiamine