title: [Peculiarities of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions].
abstract: The results of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions with organic solvents of different chemical nature and their mixtures are presented. Synergism between the distribution coefficients was demonstrated during the extraction of the above compounds with 1,4-dioxane and chloroform mixtures. The use of a chloroform--1,4-dioxane system in the molar ratio of 0.8:0.2 as a solvent resulted in the maximum values of distribution coefficients of 6-mercaptopurine and azathioprine.
authors: Ia I
authors: IaI
authors: Korenman
authors: V K
authors: VK
authors: Shormanov
authors: N Ia
authors: NIa
authors: Mokshina
authors: O A
authors: OA
authors: Krivosheeva
authors: D V
authors: DV
authors: Klimanov
mesh_terms: D001379:Azathioprine / Q000737:chemistry* / Q000633:toxicity; D002725:Chloroform / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry; D053593:Forensic Toxicology / Q000379:methods; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000633:toxicity; D059625:Liquid-Liquid Extraction / Q000379:methods*; D015122:Mercaptopurine / Q000737:chemistry* / Q000633:toxicity; D012996:Solutions / Q000737:chemistry; D012997:Solvents / Q000737:chemistry*
chemical_list: D004146:Dioxanes; D007166:Immunosuppressive Agents; D012996:Solutions; D012997:Solvents; D002725:Chloroform; D015122:Mercaptopurine; C025223:1,4-dioxane; D001379:Azathioprine