title: [Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: a guideline by the working group "Tissue Regeneration" of the German Society of Orthopaedic Surgery and Traumatology (DGOU)].
abstract: Autologous chondrocyte transplantation/implantation (ACT/ACI) is an                         established and recognised procedure for the treatment of localised                         full-thickness cartilage defects of the knee. The present review of the                         working group "Clinical Tissue Regeneration" of the German Society of                         Orthopaedics and Traumatology (DGOU) describes the biology and function of                         healthy articular cartilage, the present state of knowledge concerning                         potential consequences of primary cartilage lesions and the suitable                         indication for ACI. Based on current evidence, an indication for ACI is                         given for symptomatic cartilage defects starting from defect sizes of more                         than 3-4 cm2; in the case of young and active sports patients at                             2.5 cm2. Advanced degenerative joint disease is the single                         most important contraindication. The review gives a concise overview on                         important scientific background, the results of clinical studies and                         discusses advantages and disadvantages of ACI.
authors: Department Orthopädie und Traumatologie, Universitätsklinikum Freiburg. philipp.niemeyer@uniklinik-freiburg.de
authors: P
authors: P
authors: Niemeyer
authors: S
authors: S
authors: Andereya
authors: P
authors: P
authors: Angele
authors: A
authors: A
authors: Ateschrang
authors: M
authors: M
authors: Aurich
authors: M
authors: M
authors: Baumann
authors: P
authors: P
authors: Behrens
authors: U
authors: U
authors: Bosch
authors: C
authors: C
authors: Erggelet
authors: S
authors: S
authors: Fickert
authors: J
authors: J
authors: Fritz
authors: H
authors: H
authors: Gebhard
authors: K
authors: K
authors: Gelse
authors: D
authors: D
authors: Günther
authors: A
authors: A
authors: Hoburg
authors: P
authors: P
authors: Kasten
authors: T
authors: T
authors: Kolombe
authors: H
authors: H
authors: Madry
authors: S
authors: S
authors: Marlovits
authors: N M
authors: NM
authors: Meenen
authors: P E
authors: PE
authors: Müller
authors: U
authors: U
authors: Nöth
authors: J P
authors: JP
authors: Petersen
authors: M
authors: M
authors: Pietschmann
authors: W
authors: W
authors: Richter
authors: B
authors: B
authors: Rolauffs
authors: K
authors: K
authors: Rhunau
authors: B
authors: B
authors: Schewe
authors: A
authors: A
authors: Steinert
authors: M R
authors: MR
authors: Steinwachs
authors: G H
authors: GH
authors: Welsch
authors: W
authors: W
authors: Zinser
authors: D
authors: D
authors: Albrecht
mesh_terms: D002357:Cartilage Diseases / Q000601:surgery*; D019902:Chondrocytes / Q000637:transplantation*; D005858:Germany; D006801:Humans; D007719:Knee Joint / Q000601:surgery*; D019637:Orthopedic Procedures / Q000592:standards*; D009985:Orthopedics / Q000592:standards*; D017410:Practice Guidelines as Topic; D014194:Traumatology / Q000592:standards*