title: Chemical composition and antimicrobial activity of the volatile fractions from leaves and flowers of the wild Iraqi Kurdish plant Prangos peucedanifolia FENZL.
abstract: The volatile fractions isolated from Prangos peucedanifolia FENZL leaves and flowers were investigated for their phytochemical composition and biological properties. Flower and leaf hydrodistillation afforded 3.14 and 0.49 g of yellowish oils in 1.25 and 0.41% yields, respectively, from dry vegetable materials. According to the GC-FID and GC/MS analyses, 36 (99.35% of the total oil composition) and 26 compounds (89.12%) were identified in the two oils, respectively. The major constituents in the flower volatile fraction were β-pinene (35.58%), α-pinene (22.13%), and β-phellandrene (12.54%), while m-cresol (50.38%) was the main constituent of the leaf volatile fraction. The antimicrobial activity was evaluated against several bacterial and fungal strains, on the basis of the minimum inhibitory concentration (MIC) by the micro- and macrodilution methods. The two volatile fractions showed moderate antifungal and antibacterial activities, especially against Trichophyton rubrum (MIC of 2×10(3) μg/ml), Streptococcus mutans, Streptococcus pyogenes, and Staphylococcus aureus (MIC≤1.9×10(3) μg/ml for all).
authors: Department of Drug Sciences, University of Pavia, Pavia, Italy. gloria.brusotti@unipv.it
authors: Gloria
authors: G
authors: Brusotti
authors: Mohammed Farhad
authors: MF
authors: Ibrahim
authors: Alessandra
authors: A
authors: Dentamaro
authors: Gianluca
authors: G
authors: Gilardoni
authors: Solveig
authors: S
authors: Tosi
authors: Pietro
authors: P
authors: Grisoli
authors: Cesare
authors: C
authors: Dacarro
authors: Maria Lidia
authors: ML
authors: Guglielminetti
authors: Faiq Hama Saeed
authors: FH
authors: Hussain
authors: Gabriele
authors: G
authors: Caccialanza
authors: Giovanni
authors: G
authors: Vidari
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003408:Cresols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006801:Humans; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009181:Mycoses / Q000188:drug therapy; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D013290:Streptococcal Infections / Q000188:drug therapy; D013291:Streptococcus / Q000187:drug effects; D014005:Tinea / Q000188:drug therapy; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds; D003408:Cresols; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D039821:Monoterpenes; D009822:Oils, Volatile; C032538:4-cresol; C058582:beta-phellandrene; C010789:beta-pinene; C005451:alpha-pinene