title: [Thrombosis and obstruction associated with central venous lines. Incidence and risk factors].
abstract: OBJECTIVE
  To analyse the incidence of thrombosis and obstruction associated with central venous lines (CVL) inserted in critically ill children, and to determine their risk factors.
  
  
  METHODS
  Prospective observational study in a Pediatric Intensive Care Unit in a University Hospital.
  
  
  METHODS
  An analysis was made of 825 CVL placed in 546 patients. Age, gender, weight, type of catheter (lines, size, and brand), final location of the catheter, mechanical ventilation, type of sedation and analgesia used, initial failure by the doctor to perform CVL catheterization, number of attempts, CVL indication, admission diagnosis, emergency or scheduled procedure, and delayed mechanical complications (DMC). Risk factors for these complications were determined by a multiple regression analysis.
  
  
  RESULTS
  A total of 52 cases of DMC, 42 cases of obstruction, and 10 of thrombosis were registered. Obstruction and thrombosis rates were 4.96 and 1.18 per 100 CVL, respectively. The only risk factor independently linked to obstruction was the duration of the CVL (OR 1.05; 95% CI; 1.00-1.10). The number of lines with thrombosis (OR 4.88; 95% CI; 1.26-18.0), as well as parenteral nutrition (OR 4.17; 95% CI; 1.06-16.31) was statistically significant according to bivariate analysis. However, no risk factors for thrombosis were found in the multivariate analysis.
  
  
  CONCLUSIONS
  Obstruction and thrombosis of CVL inserted in a Pediatric Intensive Care Unit are relatively common complications. CVL duration is an independent risk factor for any line obstruction.
authors: Sección de Cuidados Intensivos Pediátricos, Área de Gestión Clínica de Pediatría, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Asturias, España. anaviall@hotmail.com
authors: A
authors: A
authors: Vivanco Allende
authors: C
authors: C
authors: Rey Galán
authors: M V
authors: MV
authors: Rodríguez de la Rúa
authors: F
authors: F
authors: Alvarez García
authors: A
authors: A
authors: Medina Villanueva
authors: A
authors: A
authors: Concha Torre
authors: J
authors: J
authors: Mayordomo Colunga
authors: P
authors: P
authors: Martínez Camblor
mesh_terms: D000293:Adolescent; D061807:Catheter Obstruction / Q000009:adverse effects* / Q000706:statistics & numerical data*; D062905:Central Venous Catheters; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology* / Q000209:etiology*
keywords: Catéter venoso central; Central venous catheter; Complicación; Complication; Cuidados intensivos; Intensive care; Obstrucción; Obstruction; Thrombosis; Trombosis