title: Fish consumption and the risk of myocardial infarction and stroke in the German arm of the European Prospective Investigation into Cancer and Nutrition (EPIC-Germany).
abstract: Recent meta-analyses have confirmed that fish consumption is related to decreased risks of ischaemic stroke and fatal CHD, while there seem to be no clear associations between fish consumption and the risks of haemorrhagic stroke and non-fatal CHD. As no studies in German populations have been reported to date, we assessed whether fish consumption as recorded by FFQ between 1994 and 1998 was related to incident myocardial infarction (MI) and stroke within the German arm of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards regression analyses were conducted based on the data of 48 315 participants aged 35–65 years at baseline. The median fish intake was 16·4 g/d (25th–75th percentile 8·2–28·8 g/d). During a mean follow-up of 8·1 years, 605 incident MI and 525 incident strokes have been documented. After multiple adjustment, fish consumption was not related to incident MI (hazard ratio (HR) 0·84, 95 % CI 0·66, 1·08, P trend= 0·21) or stroke (HR 0·96, 95 % CI 0·73, 1·26, P trend= 0·67). Separate analyses for fatal MI, ischaemic stroke and haemorrhagic stroke did not show significant associations, either. With regard to non-fatal MI, there was a non-significant trend for an inverse association (HR 0·78, 95 % CI 0·59, 1·03, P trend= 0·07). Overall, fish consumption was not related to the risks of MI and stroke in the EPIC-Germany study.
authors: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
authors: Tilman
authors: T
authors: Kühn
authors: Birgit
authors: B
authors: Teucher
authors: Rudolf
authors: R
authors: Kaaks
authors: Heiner
authors: H
authors: Boeing
authors: Cornelia
authors: C
authors: Weikert
authors: Brian
authors: B
authors: Buijsse
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D004032:Diet; D004435:Eating; D005247:Feeding Behavior; D005260:Female; D005399:Fishes; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000517:prevention & control*; D009749:Nutrition Surveys; D012307:Risk Factors; D020521:Stroke / Q000517:prevention & control*