title: Hypovitaminosis D and incidence of obesity: a prospective study.
abstract: The aim of this study was to assess the relationship between obesity and vitamin D status cross-sectionally, the relationship between obesity and the incidence of hypovitaminosis D prospectively and inversely the relationship between vitamin D status and incidence of obesity in a population-based cohort study in Spain. At baseline (1996-1998), 1226 subjects were evaluated and follow-up assessments were performed in 2002-2004 and 2005-2007, participants undergoing an interview and clinical examination with an oral glucose tolerance test. At the second visit, 25-hydroxyvitamin D and intact parathyroid hormone concentrations were also measured. Prevalence of obesity at the three visits was 28.1, 36.2 and 39.5%, respectively. The prevalence of vitamin D deficiency (25-hydroxyvitamin D ≤ 20 ng/ml (≤ 50 nmol/l)) was 34.7%. Neither obesity at baseline (OR=0.98, 95% CI: 0.69-1.40, P=0.93) nor the development of obesity between baseline and the second evaluation (OR=0.80, 95% CI: 0.48-1.33, P=0.39) were significantly associated with vitamin D status. In subjects who were non-obese (BMI <30 kg/m²) at the second evaluation, 25-hydroxyvitamin D values ≤ 17 ng/ml (≤ 42.5 nmol/l) were significantly associated with an increased risk of developing obesity in the next 4 years (OR=2.35, 95% CI: 1.03-5.4, P=0.040 after diverse adjustments). We conclude that vitamin D deficiency is associated with an increased risk of developing obesity.
authors: Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya de Málaga, Málaga, Spain. inmagonzalezmolero@hotmail.com
authors: I
authors: I
authors: González-Molero
authors: G
authors: G
authors: Rojo-Martínez
authors: S
authors: S
authors: Morcillo
authors: C
authors: C
authors: Gutierrez
authors: E
authors: E
authors: Rubio
authors: V
authors: V
authors: Pérez-Valero
authors: I
authors: I
authors: Esteva
authors: M S
authors: MS
authors: Ruiz de Adana
authors: M C
authors: MC
authors: Almaraz
authors: N
authors: N
authors: Colomo
authors: G
authors: G
authors: Olveira
authors: F
authors: F
authors: Soriguer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002112:Calcifediol / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D013030:Spain / Q000453:epidemiology; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D002112:Calcifediol