title: Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation.
abstract: Although traditional models of carcinogenesis have largely focused on neoplastic cells, converging data have revealed the importance of non-neoplastic stromal cells in influencing tumor growth and progression. Leveraging a genetically engineered mouse model of neurofibromatosis type 1 (NF1)-associated optic glioma, we now demonstrate that stromal microglia express the CX3CR1 chemokine receptor, such that reduced CX3CR1 expression decreases optic nerve microglia. Moreover, genetic reduction of Cx3cr1 expression in Nf1 optic glioma mice delays optic glioma formation. Coupled with previous findings demonstrating that microglia maintain optic glioma growth, these new findings provide a strong preclinical rationale for the development of future stroma-directed glioma therapies in children.
authors: Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.
authors: Winnie W
authors: WW
authors: Pong
authors: Samantha B
authors: SB
authors: Higer
authors: Scott M
authors: SM
authors: Gianino
authors: Ryan J
authors: RJ
authors: Emnett
authors: David H
authors: DH
authors: Gutmann
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000473:pathology / Q000502:physiology; D000073883:CX3C Chemokine Receptor 1; D004195:Disease Models, Animal; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017628:Microglia / Q000473:pathology / Q000502:physiology*; D009456:Neurofibromatosis 1 / Q000235:genetics / Q000473:pathology*; D025542:Neurofibromin 1 / Q000235:genetics; D009900:Optic Nerve / Q000473:pathology / Q000502:physiology*; D020339:Optic Nerve Glioma / Q000235:genetics / Q000473:pathology*; D019707:Receptors, Chemokine / Q000235:genetics*
chemical_list: D000073883:CX3C Chemokine Receptor 1; C471885:Cx3cr1 protein, mouse; D025542:Neurofibromin 1; D019707:Receptors, Chemokine