title: Cerebral white matter blood flow and energy metabolism in multiple sclerosis.
abstract: BACKGROUND
  Cerebral blood flow (CBF) is reduced in normal-appearing white matter (NAWM) of subjects with multiple sclerosis (MS), but the underlying mechanism is unknown.
  
  
  OBJECTIVE
  The objective of this article is to assess the relationship between reduced NAWM CBF and both axonal mitochondrial metabolism and astrocytic phosphocreatine (PCr) metabolism.
  
  
  METHODS
  Ten healthy controls and 25 MS subjects were studied with 3 Tesla magnetic resonance imaging. CBF was measured using pseudo-continuous arterial spin labeling. N-acetylaspartate/creatine (NAA/Cr) ratios (axonal mitochondrial metabolism) were obtained using (1)H-MR spectroscopy and PCr/β-ATP ratios using (31)P-MR spectroscopy. In centrum semiovale NAWM, we assessed correlations between CBF and both NAA/Cr and PCr/β-ATP ratios.
  
  
  RESULTS
  Subjects with MS had a widespread reduction in CBF of NAWM (centrum semiovale, periventricular, frontal and occipital), and gray matter (frontoparietal cortex and thalamus). Compared to controls, NAA/Cr in NAWM of the centrum semiovale of MS subjects was decreased, whereas PCr/β-ATP was increased. We found no correlations between CBF and PCr/β-ATP. CBF and NAA/Cr correlated in controls (p = 0.02), but not in MS subjects (p = 0.68).
  
  
  CONCLUSIONS
  Our results suggest that in MS patients there is no relationship between reduced CBF in NAWM and impaired axonal mitochondrial metabolism or astrocytic PCr metabolism.
authors: Department of Neurology, Universitair Medisch Centrum Groningen, The Netherlands.
authors: Christel
authors: C
authors: Steen
authors: Miguel
authors: M
authors: D'haeseleer
authors: Johannes M
authors: JM
authors: Hoogduin
authors: Yves
authors: Y
authors: Fierens
authors: Melissa
authors: M
authors: Cambron
authors: Jop P
authors: JP
authors: Mostert
authors: Dorothea J
authors: DJ
authors: Heersema
authors: Marcus W
authors: MW
authors: Koch
authors: Jacques
authors: J
authors: De Keyser
mesh_terms: D001921:Brain / Q000098:blood supply* / Q000473:pathology; D002560:Cerebrovascular Circulation; D004578:Electron Spin Resonance Spectroscopy; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism; D009103:Multiple Sclerosis / Q000378:metabolism / Q000503:physiopathology*; D009413:Nerve Fibers, Myelinated / Q000378:metabolism*; D013113:Spin Labels
chemical_list: D013113:Spin Labels
keywords: Multiple sclerosis; N-acetylaspartate; arterial spin labeling; cerebral blood flow; magnetic resonance spectroscopy; phosphocreatine