title: Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model.
abstract: Cytotoxic T lymphocytes (CTLs) constitute a major effector population in pancreatic islets from patients suffering from type 1 diabetes (T1D) and thus represent attractive targets for intervention. Some studies have suggested that blocking the interaction between the chemokine CXCL10 and its receptor CXCR3 on activated CTLs potently inhibits their recruitment and prevents β-cell death. Since recent studies on human pancreata from T1D patients have indicated that both ligand and receptor are abundantly present, we reevaluated whether their interaction constitutes a pivotal node within the chemokine network associated with T1D. Our present data in a viral mouse model challenge the notion that specific blockade of the CXCL10/CXCR3 chemokine axis halts T1D onset and progression.
authors: Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
authors: Ken T
authors: KT
authors: Coppieters
authors: Natalie
authors: N
authors: Amirian
authors: Philippe P
authors: PP
authors: Pagni
authors: Carmen
authors: C
authors: Baca Jones
authors: Anna
authors: A
authors: Wiberg
authors: Stanley
authors: S
authors: Lasch
authors: Edith
authors: E
authors: Hintermann
authors: Urs
authors: U
authors: Christen
authors: Matthias G
authors: MG
authors: von Herrath
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing; D054357:Chemokine CXCL10 / Q000037:antagonists & inhibitors*; D003921:Diabetes Mellitus, Experimental / Q000276:immunology* / Q000821:virology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000821:virology; D007515:Islets of Langerhans / Q000276:immunology*; D051379:Mice; D054367:Receptors, CXCR3 / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D054357:Chemokine CXCL10; C485433:Cxcl10 protein, mouse; C515188:Cxcr3 protein, mouse; D054367:Receptors, CXCR3