title: Copper-catalyzed trifluoromethylation of aryl- and vinylboronic acids with generation of CF3-radicals.
abstract: The selective trifluoromethylation of aryl- and vinylboronic acids proceeds smoothly with CF3SO2Na (Langlois reagent) in the presence of copper catalysts and t-BuOOH. Therefore, the method relies both on transition metal catalysis and selective radical reactions. Advantageously, the protocol can be performed at room temperature under an air atmosphere and avoids the issue of poor regioselectivity.
authors: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert Einstein Str. 29a, 18059 Rostock, Germany.
authors: Yang
authors: Y
authors: Li
authors: Lipeng
authors: L
authors: Wu
authors: Helfried
authors: H
authors: Neumann
authors: Matthias
authors: M
authors: Beller
mesh_terms: D001897:Boronic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001897:Boronic Acids; D005609:Free Radicals; D009942:Organometallic Compounds; D003300:Copper