title: Two antiproliferative triterpene saponins from Nematostylis anthophylla from the highlands of Central Madagascar.
abstract: Investigation of the endemic Madagascan plant Nematostylis anthophylla (Rubiaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the known triterpene saponin randianin (1), and the two new bioactive triterpene saponins 2"-O-acetylrandianin (2) and 6"-O-acetylrandianin (3). The structures of the two new compounds were elucidated based on analysis of their 1D- and 2D-NMR spectra, and mass spectrometric data. The three isolated triterpene saponins displayed moderate but selective antiproliferative activities, with IC(50) values of 1.2, 1.7, and 2.2 μM, respectively, against the A2780 ovarian cancer, but only weak inhibitions of the proliferation of A2058 melanoma and the H522 lung cancer cell lines.
authors: Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, USA.
authors: Yumin
authors: Y
authors: Dai
authors: Liva
authors: L
authors: Harinantenaina
authors: Peggy J
authors: PJ
authors: Brodie
authors: Chris
authors: C
authors: Birkinshaw
authors: Richard
authors: R
authors: Randrianaivo
authors: Wendy
authors: W
authors: Applequist
authors: Michel
authors: M
authors: Ratsimbason
authors: Vincent E
authors: VE
authors: Rasamison
authors: Yongchun
authors: Y
authors: Shen
authors: Karen
authors: K
authors: TenDyke
authors: David G I
authors: DG
authors: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008270:Madagascar; D008545:Melanoma / Q000188:drug therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D019666:Rubiaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes