title: Associations between polymorphisms in the antiviral TRIM genes and measles vaccine immunity.
abstract: The role of polymorphisms within the antiviral tripartite motif (TRIM) genes in measles vaccine adaptive immune responses was examined. A limited association was found between TRIM5 (rs7122620) and TRIM25 (rs205499) gene polymorphisms and measles-specific antibody levels. However, many associations were found between TRIM gene SNPs and variations in cellular responses (IFN-γ Elispot and secreted cytokines IL-2, IL-6, IL-10, IFN-γ, and TNF-α). TRIM22 rs2291841 was significantly associated with an increased IFN-γ Elispot response (35 vs. 102 SFC per 2×10(5)PBMC, p=0.009, q=0.71) in Caucasians. A non-synonymous TRIM25 rs205498 (in LD with other SNPs, r(2)≥0.56), as well as the TRIM25 AAAGGAAAGGAGT haplotype, was associated with a decreased IFN-γ Elispot response (t-statistic -2.32, p=0.02) in African-Americans. We also identified polymorphisms in the TRIM5, TRIM22, and TRIM25 genes that were associated with significant differences in cytokine responses. Additional studies are necessary to replicate our findings and to examine the functional consequences of these associations.
authors: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, United States.
authors: Inna G
authors: IG
authors: Ovsyannikova
authors: Iana H
authors: IH
authors: Haralambieva
authors: Robert A
authors: RA
authors: Vierkant
authors: Megan M
authors: MM
authors: O'Byrne
authors: Gregory A
authors: GA
authors: Poland
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000276:immunology; D000293:Adolescent; D000483:Alleles; D000914:Antibodies, Viral / Q000276:immunology; D002648:Child; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D008457:Measles / Q000235:genetics* / Q000276:immunology* / Q000517:prevention & control; D008458:Measles Vaccine / Q000276:immunology*; D008565:Membrane Proteins / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000914:Antibodies, Viral; D016207:Cytokines; D008458:Measles Vaccine; D008565:Membrane Proteins; C114030:TRAT1 protein, human; D007371:Interferon-gamma