title: Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes.
abstract: The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe₂PO and Fe₂PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe₂PO and Fe₂PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.
authors: Departamento de Investigación en Polímeros y Materiales-DIPM, Universidad de Sonora, Calle Rosales y Blvd, Luis Encinas s/n, Col. Centro, PO Box 130, Hermosillo Sonora 83000, Mexico.
authors: Alex J
authors: AJ
authors: Salazar-Medina
authors: Rocío
authors: R
authors: Sugich-Miranda
authors: Eli
authors: E
authors: Teran-Cabanillas
authors: Jesús
authors: J
authors: Hernández
authors: Gustavo A
authors: GA
authors: González-Aguilar
authors: Enrique
authors: E
authors: Rudiño-Piñera
authors: Rogerio R
authors: RR
authors: Sotelo-Mundo
authors: Enrique F
authors: EF
authors: Velázquez-Contreras
mesh_terms: D000042:Absorption; D000975:Antioxidants / Q000494:pharmacology*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D019610:Cytoprotection / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D004988:Ethers, Cyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000737:chemistry / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D013058:Mass Spectrometry; D010084:Oxidation-Reduction / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D011522:Protons; D013055:Spectrophotometry, Infrared; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D056831:Coordination Complexes; D004988:Ethers, Cyclic; D011522:Protons; D007501:Iron; D009195:Peroxidase; D013482:Superoxide Dismutase