title: Influence of long-term drinking alcohol on the cytokines in the rats with endogenous and exogenous lung injury.
abstract: BACKGROUND
  Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are syndromes of acute respiratory failure.
  
  
  OBJECTIVE
  Exploration of the impacts of long-term drinking alcohol on the cytokines of rats with endogenous and exogenous lung injuries.
  
  
  METHODS
  Through giving the model rats long-term drinking alcohol or water, we acquired the changes of the cytokines in the serum and bronchoalveolar lavage fluid (BALF) of these rats with lung injuries due to different incentives.
  
  
  RESULTS
  The partial pressure of oxygen in rats with lung damage after long-term drinking alcohol were significantly lower than those drinking water group (p < 0.05); W/D values of groups drinking alcohol were significantly higher than those drinking water (p < 0.05); The levels of TNF-alpha, IL-6 and IL-10 in the serum and BALF were significantly higher in the group drinking alcohol (p < 0.01). While the cytokine levels in the serum of the rats with exogenous lung injury were higher than those of rats with endogenous lung injury (p < 0.05), the cytokines in the BALF of the rats with endogenous lung injury were higher than those with exogenous lung injury (p < 0.05).
  
  
  CONCLUSIONS
  Long-term drinking alcohol can aggravate the inflammatory response induced by the exogenous lung injury. The expression of TNF-α, IL-6 and IL-10 are different according to the different ways that lead to the acute lung injury.
authors: Department of Emergency, The First Affiliated Hospital of China Medical University, Shenyang, P.R. China.
authors: Y D
authors: YD
authors: Liu
authors: W
authors: W
authors: Liu
authors: Z
authors: Z
authors: Liu
mesh_terms: D055371:Acute Lung Injury / Q000503:physiopathology*; D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects*; D016753:Interleukin-10 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D000431:Ethanol; D010100:Oxygen