title: Impact of preoperative C-reactive protein on midterm outcomes after off-pump coronary artery bypass grafting.
abstract: BACKGROUND
  We aimed to assess the impact of C-reactive protein (CRP) on clinical outcomes after off-pump coronary artery bypass grafting (OPCABG).
  
  
  METHODS
  Seven hundred fifty-five consecutive OPCABG patients were divided into two groups according to their preoperative CRP level (normal CRP [NCRP] group [CRP ≤ 6.0 mg/L] versus high CRP [HCRP] group [CRP > 6.0 mg/L]). Outcome measurements were cardiac death and major adverse cardiac and cerebrovascular event (MACCE).
  
  
  RESULTS
  Early mortality was higher in the HCRP group (p = 0.036). During follow-up, cardiac mortality was 1.2% in the NCRP group and 7.1% in the HCRP group (p < 0.001). The overall MACCE incidence was 11.2% in the NCRP group and 16.5% in the HCRP group (p = 0.042). All-cause mortality was the only determining factor (p < 0.001), whereas the incidences of myocardial infarction, stroke, and repeat revascularization were similar between the two groups (p = 0.987, p = 0.201, p = 0.426). The 3-year freedom rates from cardiac death and MACCE were 98.8 ± 0.5% and 87.5 ± 1.6% in the NCRP group and 92.5 ± 1.7% and 84.3 ± 2.5% in the HCRP group (p < 0.001, p = 0.09, respectively).
  
  
  CONCLUSIONS
  Patients with HCRP level showed worse clinical outcomes regarding cardiac death and MACCE after OPCABG.
authors: Department of Thoracic and Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Gijong
authors: G
authors: Yi
authors: Hyun-Chel
authors: HC
authors: Joo
authors: Kyung-Jong
authors: KJ
authors: Yoo
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000401:mortality; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000401:mortality; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006331:Heart Diseases / Q000209:etiology / Q000401:mortality; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein