title: Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main contributing factors to the pathology of SLE is the accumulation and impaired clearance of immune complexes of which the principle components are host auto-antigens and antibodies. The contribution of host lipids to the formation of these autoimmune complexes remains poorly defined. The aim of the present study was to identify and analyze candidate lipid autoantigens and their corresponding anti-lipid antibody responses in a well-defined SLE patient cohort using a combination of immunological and biophysical techniques. Disease monitoring in the SLE cohort was undertaken with serial British Isles Lupus Assessment Group (BILAG) scoring. Correlations between specific lipid/anti-lipid responses were investigated as disease activity developed from active flares to quiescent during a follow up period. We report a significant negative correlation between anti-lipid antibodies for 24S-hydroxycholesterol, cardiolipin and phosphatidylserine with SLE disease activity. Taken together, these data suggest that lipid autoantigens represent a new family of biomarkers that can be employed to monitor disease activity plus the efficacy of therapeutic intervention in SLE.
authors: Immunology Programme and Department of Microbiology, National University of Singapore, Singapore.
authors: Vojislav
authors: V
authors: Jovanović
authors: Nurhuda
authors: N
authors: Abdul Aziz
authors: Yan Ting
authors: YT
authors: Lim
authors: Amanda
authors: A
authors: Ng Ai Poh
authors: Sherlynn
authors: S
authors: Jin Hui Chan
authors: Eliza
authors: E
authors: Ho Xin Pei
authors: Fei Chuin
authors: FC
authors: Lew
authors: Guanghou
authors: G
authors: Shui
authors: Andrew M
authors: AM
authors: Jenner
authors: Li
authors: L
authors: Bowen
authors: Eoin F
authors: EF
authors: McKinney
authors: Paul A
authors: PA
authors: Lyons
authors: Michael D
authors: MD
authors: Kemeny
authors: Kenneth G C
authors: KG
authors: Smith
authors: Markus R
authors: MR
authors: Wenk
authors: Paul A
authors: PA
authors: Macary
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D015415:Biomarkers / Q000378:metabolism; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008055:Lipids / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G; D008055:Lipids