title: Differential associations of abdominal visceral, subcutaneous adipose tissue with cardiometabolic risk factors between African and European Americans.
abstract: OBJECTIVE
  To examine the relative association of abdominal visceral adipose tissue (VAT) with cardiometabolic risk factors between African and European Americans.
  
  
  METHODS
  A cross-sectional study of 2,035 African Americans from the Jackson Heart Study (JHS) and 3,170 European Americans from the Framingham Heart Study (FHS) who underwent computed tomography assessment of VAT and subcutaneous adipose tissue (SAT) was conducted. The FHS participants were weighted to match the age distribution of the JHS participants, and the metabolic risk factors were examined by study groups in relation to VAT.
  
  
  RESULTS
  JHS participants had higher rates of obesity, hypertension, diabetes, and metabolic syndrome than FHS participants (all P = 0.001). The associations were weaker in JHS women for VAT with blood pressure, triglycerides, HDL-C, and total cholesterol (Pinteraction = 0.03-0.001) than FHS women. In contrast, JHS men had stronger associations for VAT with high triglycerides, low HDL, and metabolic syndrome (all Pinteraction = 0.001) compared to FHS men. Similar associations and gender patterns existed for SAT with most metabolic risk factors.
  
  
  CONCLUSIONS
  The relative association between VAT and cardiometabolic risk factors is weaker in JHS women compared to FHS women, whereas stronger associations with triglycerides and HDL were observed in JHS men.
authors: Jackson Heart Study, University of Mississippi Medical Center, Jackson State University, Jackson, MS, USA.
authors: Jiankang
authors: J
authors: Liu
authors: Sean
authors: S
authors: Coady
authors: J Jeffery
authors: JJ
authors: Carr
authors: Udo
authors: U
authors: Hoffmann
authors: Herman A
authors: HA
authors: Taylor
authors: Caroline S
authors: CS
authors: Fox
mesh_terms: D001741:Black or African American; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D050152:Intra-Abdominal Fat; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000378:metabolism; D050507:Subcutaneous Fat, Abdominal; D014280:Triglycerides / Q000097:blood; D044465:White People
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides