title: Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens.
abstract: We initiated a pilot study to investigate the effects of 8 wks of aerobic exercise training (ET) on insulin sensitivity and inflammatory markers in obese and insulin-resistant minority adolescents. Eleven morbidly obese (BMI 41.4 ± 1.8 kg/m2) minority adolescents were entered into a supervised ET intervention (~180 min/wk at 40-55%VO2PeakR [(VO2Peak-VO2Rest)/VO2Rest]). The effects of training on insulin sensitivity (SI), inflammation and other metabolic syndrome features were examined.
  
  
  RESULTS
  Insulin action improved in response to training, as indicated by a ~37% increase in SI (p = .018). Plasma levels of several proinflammatory cytokines were reduced in response to ET, as indicated by significant decrements in sTNF-R, CCL2, MPO, IL-6, resistin, and leptin, with no significant changes in hsCRP. ET induced reductions in BMI and percent total body fat.
  
  
  CONCLUSIONS
  The present study supports the efficacy of ET interventions on metabolic syndrome features in morbidly obese minority youth.
authors: Children's National Medical Center, Research Center for Genetics Medicine, Washington, DC, USA.
authors: Gina
authors: G
authors: Many
authors: Maria-Eugenia
authors: ME
authors: Hurtado
authors: Charles
authors: C
authors: Tanner
authors: Joseph
authors: J
authors: Houmard
authors: Heather
authors: H
authors: Gordish-Dressman
authors: Jung-Jun
authors: JJ
authors: Park
authors: Gabriel
authors: G
authors: Uwaifo
authors: William
authors: W
authors: Kraus
authors: James
authors: J
authors: Hagberg
authors: Eric
authors: E
authors: Hoffman
mesh_terms: D000293:Adolescent; D001741:Black or African American; D001823:Body Composition; D001835:Body Weight; D018932:Chemokine CCL2 / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005081:Exercise Therapy; D005260:Female; D005951:Glucose Tolerance Test; D006630:Hispanic or Latino; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000097:blood; D008297:Male; D009767:Obesity, Morbid / Q000208:ethnology / Q000503:physiopathology* / Q000628:therapy*; D010101:Oxygen Consumption; D009195:Peroxidase / Q000097:blood; D010865:Pilot Projects; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D052243:Resistin / Q000097:blood; D018709:Statistics, Nonparametric
chemical_list: D018932:Chemokine CCL2; D020738:Leptin; D018124:Receptors, Tumor Necrosis Factor; D052243:Resistin; D009195:Peroxidase