title: [Malignant transformation of multiple isolated hepatocellular adenomas. Therapeutic implications of immunohistochemical and radiological findings].
abstract: Malignant transformation of hepatic adenoma (HA) is now a well-documented phenomenon. Recent pathological and immunophenotypic studies have identified several subtypes with different prognoses. In many cases the HA subtype can be determined by modern radiological methods, including contrast-enhanced ultrasonography (CEUS) and magnetic resonance imaging (MRI). Based on a series of 26 cases of HA studied with CEUS, MR1 histopathology and immunochemistry, we propose tailored therapeutic options. Watchful waiting is appropriate in some cases, while others require biopsy or resection. Management is more conservative than in previous years.
authors: Hôpital de la Croix Rousse, 103 Grande rue de la Croix Rousse-69317 Lyon. jbaulieux@aol.com
authors: Jacques
authors: J
authors: Baulieux
authors: Anne-Frédérique
authors: AF
authors: Manichon
authors: Brigitte
authors: B
authors: Bancel
authors: Emmanuel
authors: E
authors: D'Errico
authors: Olivier
authors: O
authors: Raspado
authors: Christian
authors: C
authors: Ducerf
authors: Jean-Yves
authors: JY
authors: Mabrut
authors: Agnés
authors: A
authors: Rode
mesh_terms: D018248:Adenoma, Liver Cell / Q000235:genetics / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology*; D009154:Mutation; D051176:beta Catenin / Q000235:genetics
chemical_list: C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D051176:beta Catenin