title: Probability and predictors of cannabis use disorders relapse: results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).
abstract: BACKGROUND
  This study aims to estimate the odds and predictors of Cannabis Use Disorders (CUD) relapse among individuals in remission.
  
  
  METHODS
  Analyses were done on the subsample of individuals with lifetime history of a CUD (abuse or dependence) who were in full remission at baseline (Wave 1) of the National Epidemiological Survey of Alcohol and Related Conditions (NESARC) (n=2350). Univariate logistic regression models and hierarchical logistic regression model were implemented to estimate odds of relapse and identify predictors of relapse at 3 years follow up (Wave 2).
  
  
  RESULTS
  The relapse rate of CUD was 6.63% over an average of 3.6 year follow-up period. In the multivariable model, the odds of relapse were inversely related to time in remission, whereas having a history of conduct disorder or a major depressive disorder after Wave 1 increased the risk of relapse.
  
  
  CONCLUSIONS
  Our findings suggest that maintenance of remission is the most common outcome for individuals in remission from a CUD. Treatment approaches may improve rates of sustained remission of individuals with CUD and conduct disorder or major depressive disorder.
authors: Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States. florezl@nyspi.columbia.edu
authors: Ludwing
authors: L
authors: Flórez-Salamanca
authors: Roberto
authors: R
authors: Secades-Villa
authors: Alan J
authors: AJ
authors: Budney
authors: Olaya
authors: O
authors: García-Rodríguez
authors: Shuai
authors: S
authors: Wang
authors: Carlos
authors: C
authors: Blanco
mesh_terms: D000293:Adolescent; D000328:Adult; D003625:Data Collection; D017831:Diagnosis, Dual (Psychiatry) / Q000706:statistics & numerical data; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006306:Health Surveys; D006801:Humans; D016015:Logistic Models; D008297:Male; D002189:Marijuana Abuse / Q000453:epidemiology* / Q000517:prevention & control*; D001523:Mental Disorders / Q000150:complications / Q000523:psychology; D011336:Probability; D011379:Prognosis; D012008:Recurrence; D012306:Risk; D012959:Socioeconomic Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Abuse; CUD; Cannabis; Cannabis use disorder; Dependence; Marijuana; NESARC; Relapse; Remission