title: The serum protein α2-Heremans-Schmid glycoprotein/fetuin-a concentration and carotid intima-media thickness in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate fetuin-A concentrations and its association with metabolic and sonographic cardiovascular markers in women with polycystic ovary syndrome (PCOS) and healthy subjects.
  
  
  METHODS
  Thirty-five women with PCOS and 37 healthy control women were matched for body mass index (BMI) and age. Serum fetuin-A concentrations, and reproductive and adrenal hormones were measured, and insulin resistance and carotid intima media thickness (CIMT) were evaluated in both groups. The correlations between cardiovascular risk factors, CIMT and fetuin-A concentrations were tested.
  
  
  RESULTS
  Mean fetuin-A concentrations were significantly elevated in the PCOS group compared with control subjects (101.2 ng/ml ± 33.55 vs. 82.5 ng/ml ± 32.65, P=0.019). CIMT was also higher in women with PCOS than in control subjects (0.51 ± 0.05 mm vs. 0.44 ± 0.05 mm, P<0.01). Serum lipid parameters were correlated to serum fetuin-A concentrations in the PCOS group, but no correlation was found between fetuin-A and CIMT (rPCOS=0.244, pPCOS=0.158; rcontrol=-0.002, pcontrol=0.988).
  
  
  CONCLUSIONS
  In this, the first study of fetuin-A concentrations in PCOS, the results showed that fetuin-A concentrations were increased in euglycemic patients with PCOS.
authors: Namik Kemal University, Faculty of Medicine, Department of Gynecology and Obstetrics, Tekirdag, Turkey. rabali@nku.edu.tr
authors: Remzi
authors: R
authors: Abali
authors: Cem
authors: C
authors: Celik
authors: Nicel
authors: N
authors: Tasdemir
authors: Savas
authors: S
authors: Guzel
authors: Seref
authors: S
authors: Alpsoy
authors: Aytac
authors: A
authors: Yuksel
authors: Elcin
authors: E
authors: Celik
mesh_terms: D000328:Adult; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D060749:alpha-2-HS-Glycoprotein