title: Cerebellar hyperperfusion in semantic dementia.
abstract: Despite evidence of a cerebellar contribution to language, possible functional changes of the cerebellum in patients with language impairment secondary to cerebral neurodegeneration has not been investigated so far. We examined with resting perfusion single photon emission tomography one patient with semantic dementia and the data were compared with a normal subject database. Region of interest and Statistical Parametric Mapping 2 analysis showed in the patient hypoperfusion of the left temporal and parietal lobe and hyperperfusion in the superior vermis and cerebellar hemispheres (lobules IV, V, and VI). The cerebellum shows increased flow of possible compensatory significance in patients with language disturbance associated to cerebral degenerative changes.
authors: a Nuclear Medicine, "Le Scotte" Hospital, University of Siena , Siena , Italy.
authors: Alessandra
authors: A
authors: Vella
authors: Riccardo
authors: R
authors: Della Nave
authors: Roberto
authors: R
authors: Vetrugno
authors: Stefano
authors: S
authors: Diciotti
authors: Stefania
authors: S
authors: Boschi
authors: Fabrizio
authors: F
authors: Banci Bonamici
authors: Mario
authors: M
authors: Mascalchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018888:Aphasia, Primary Progressive / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000209:etiology; D002531:Cerebellum / Q000098:blood supply* / Q000000981:diagnostic imaging; D005260:Female; D057180:Frontotemporal Dementia / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon