title: Cerebral atrophy is an independent risk factor for unfavorable outcome after spontaneous supratentorial intracerebral hemorrhage.
abstract: OBJECTIVE
  To investigate the influence of cerebral atrophy on clinical outcome in patients with supratentorial intracerebral hemorrhage.
  
  
  METHODS
  Computed tomography scans of 320 patients included in a prospective, multicenter trial were used for a segmentation analysis to determine the supratentorial cerebral volume. A logistic regression analysis was used to explore its effect on outcome after 90 days in addition to other clinical and imaging parameters.
  
  
  RESULTS
  Cerebral volume loss significantly reduced the odds for favorable outcome after 90 days (odds ratio=0.91; confidence interval, 0.85-0.99; P=0.02).
  
  
  CONCLUSIONS
  Cerebral atrophy is an independent predictor of unfavorable outcome after intracerebral hemorrhage, indicating reduced functional recovery potential in these individuals.
authors: Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany. christian.herweh@med.uni-heidelberg.de
authors: Christian
authors: C
authors: Herweh
authors: Eric
authors: E
authors: Prager
authors: Marek
authors: M
authors: Sykora
authors: Martin
authors: M
authors: Bendszus
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000175:diagnosis* / Q000473:pathology; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D015233:Models, Statistical; D016017:Odds Ratio; D011446:Prospective Studies; D012044:Regression Analysis; D015203:Reproducibility of Results; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome