title: Coumarins and a naphthyl labdanoate diarabinoside from the fruits of Peucedanum grande C. B. Clarke.
abstract: Phytochemical investigations of the methanolic extract of the fruits of Peucedanum grande C. B. Clarke (Apiaceae) led to the identification of three coumarins and a naphthyl labdanoate diarabinoside characterized as 5-hydroxy-6-isopranyl coumarin (1), 5,6-furanocoumarin (2), 7-methoxy-5,6-furanocoumarin (3), and labdanyl-3alpha-ol-18-(3'"-methoxy-2"'-naphthyl-oate)-3alpha-L-arabinofuranosyl-(2'-->1")-alpha-L-arabinofuranoside (4). The structures of these compounds were identified on the basis of spectral data analysis and chemical reactions. The methanolic extract and 4 showed nephroprotective activity against gentamicin-induced nephrotoxicity in Wistar rats.
authors: Department of Ilmul Advia, Faculty of Unani Medicine, Jamia Hamdard, New Delhi-110062, India.
authors: Mohammad
authors: M
authors: Aslam
authors: Mohammed
authors: M
authors: Ali
authors: Rameshwar
authors: R
authors: Dayal
authors: Kalim
authors: K
authors: Javed
mesh_terms: D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D004224:Diterpenes / Q000138:chemical synthesis / Q000302:isolation & purification*; D006027:Glycosides / Q000138:chemical synthesis / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D017208:Rats, Wistar; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003374:Coumarins; D004224:Diterpenes; D006027:Glycosides; C578643:labdanyl-3alpha-ol-18-(3'''-methoxy-2'''-naphthyl-oate)-3alpha-L-arabinofuranosyl-(2'''-1'')-alpha-L-arabinofuranoside