title: [Clinical observation of surgical management for recurrent giant cell tumor of bone].
abstract: OBJECTIVE
  To discuss the surgical selection and effectiveness for patients with recurrent giant cell tumor of bone.
  
  
  METHODS
  Between February 1988 and June 2007, 79 patients with recurrent giant cell tumor of bone were treated. There were 42 males and 37 females, with a mean age of 33.1 years (range, 15-72 years). In primary surgery, 76 patients underwent intralesional curettage, and the other 3 patients underwent resection; the recurrence time was 2-176 months after primary surgery. The locations of tumor were upper extremities in 14 cases and lower extremities in 65 cases. According to Companacci grade, 1 case was at grade I, 33 cases at grade II, and 45 cases at grade III before primary surgery. In secondary operation, 37 patients underwent intralesional curettage and bone grafting combined with adjuvant inactivated, and 42 patients underwent wide resection.
  
  
  RESULTS
  Bone allograft immune rejection occurred in 2 cases, which led to poor healing; primary healing of incision was obtained in the other patients. The patients were followed up 68 months on average (range, 18-221 months). Recurrence occurred in 12 patients at 6-32 months after operation. The re-recurrence rate was 24.3% (9/37) in cases of intralesional curettage and bone grafting combined with adjuvant inactivated, and they were given the wide resection. The re-recurrence rate was 7.1% (3/42) in cases of wide resection and they were amputated. There was significant difference in the re-recurrence rate between the intralesional curettage and the wide resection (chi2 = 4.508, P = 0.034). No recurrence was observed during 3-year follow-up among re-recurrence patients.
  
  
  CONCLUSIONS
  For benign recurrent giant cell tumor of bone, intralesional curettage and bone grafting combined with adjunctive therapy could get an acceptable effectiveness, however, it has higher local recurrence than wide resection. For large tumor and recurrent malignant giant cell tumor of bone, wide resection is recommended.
authors: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, PR China.
authors: Qingquan
authors: Q
authors: Kong
authors: Jin
authors: J
authors: Yang
authors: Rong
authors: R
authors: Xing
authors: Chongqi
authors: C
authors: Tu
authors: Yong
authors: Y
authors: Zhou
authors: Hui
authors: H
authors: Zhang
authors: Hong
authors: H
authors: Duan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D016025:Bone Transplantation; D003131:Combined Modality Therapy; D005121:Extremities; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D009367:Neoplasm Staging; D012086:Reoperation; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents