title: Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes.
abstract: Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.
authors: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, Urbana, IL 61801, USA.
authors: Lichen
authors: L
authors: Yin
authors: Ziyuan
authors: Z
authors: Song
authors: Kyung Hoon
authors: KH
authors: Kim
authors: Nan
authors: N
authors: Zheng
authors: Nathan P
authors: NP
authors: Gabrielson
authors: Jianjun
authors: J
authors: Cheng
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D048271:Chitosan / Q000737:chemistry; D004247:DNA / Q000235:genetics; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D015195:Drug Design; D056945:Hep G2 Cells; D006801:Humans; D008156:Luciferases / Q000235:genetics; D008358:Mannose / Q000378:metabolism*; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D010957:Plasmids / Q000235:genetics; D011108:Polymers / Q000737:chemistry; D014162:Transfection / Q000379:methods*
chemical_list: D004337:Drug Carriers; D011108:Polymers; D004247:DNA; D048271:Chitosan; D008156:Luciferases; D008358:Mannose