title: Ratiometric fluorescence sensing and intracellular imaging of Al3+ ions driven by an intramolecular excimer formation of a pyrimidine-pyrene scaffold.
abstract: An Al(3+) selective ratiometric fluorescent probe (L) has been synthesized by condensation of 4,5-diaminopyrimidine with 1-pyrenecarboxaldehyde. The structure of L has been confirmed by single crystal X-ray analysis. In the presence of Al(3+), L exhibits a considerable excimer emission at 445 nm along with the decrease of its monomer emission at 368 nm in DMSO-H2O (4 : 1, v/v). The lowest detection limit for Al(3+) is 0.24 μM. Furthermore, L can permeate through the cell membrane and detects intracellular Al(3+) ions under a fluorescence microscope.
authors: Department of Chemistry, The University of Burdwan, Burdwan, 713104, West Bengal, India.
authors: Sudipta
authors: S
authors: Das
authors: Animesh
authors: A
authors: Sahana
authors: Arnab
authors: A
authors: Banerjee
authors: Sisir
authors: S
authors: Lohar
authors: Damir A
authors: DA
authors: Safin
authors: Maria G
authors: MG
authors: Babashkina
authors: Michael
authors: M
authors: Bolte
authors: Yann
authors: Y
authors: Garcia
authors: Ipsit
authors: I
authors: Hauli
authors: Subhra Kanti
authors: SK
authors: Mukhopadhyay
authors: Debasis
authors: D
authors: Das
mesh_terms: D000535:Aluminum / Q000032:analysis*; D001407:Bacillus / Q000166:cytology; D002175:Candida / Q000166:cytology; D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D008856:Microscopy, Fluorescence; D008968:Molecular Conformation; D011721:Pyrenes / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D007477:Ions; D011721:Pyrenes; D011743:Pyrimidines; C036464:pyrene-1-aldehyde; D000535:Aluminum; C030986:pyrimidine