title: Serum lipids alterations in adenoid hypertrophy or adenotonsillar hypertrophy children with sleep disordered breathing.
abstract: OBJECTIVE
  We aimed to investigate metabolic parameters in children with adenoid hypertrophy (AH) only or adenotonsillar hypertrophy (ATH) and compare them with healthy controls.
  
  
  METHODS
  Forty-four prepubertal children aged 6-12 years who were obstructive symptoms and 16 healthy children were recruited in this study. All children underwent a complete otolaryngologic examination and sleep screening. The patients were divided into three groups according to obstruction type: normal, AH (adenoid grade III or IV, tonsil grade 1 or 2), and ATH (adenoid grade III or IV, tonsil grade 3 or 4). All participants underwent hematologic and biochemical tests including fasting blood glucose, insulin, and plasma lipids.
  
  
  RESULTS
  (1) The children with AH and ATH had lower high-density lipoprotein cholesterol (HDL-C), when compared to normal children. (2) The level of HDL-C was negatively correlated with the sum of adenoid and tonsillar size scores and the apnea-hypopnea index (AHI) (r=-0.477, p<0.001 vs. r=-0.548, p<0.001, respectively). There was a modest association between HDL-C and minimal SpO₂ (r=0.332, p=0.009). (3) Stepwise multiple regression analysis identified the AHI, triglycerides, and fasting insulin as independent predictors for HDL-C.
  
  
  CONCLUSIONS
  Patients with adenoid and tonsil hypertrophy had low HDL-C. HDL-C levels are inversely related to the sum of adenoid and tonsillar size scores and AHI in SDB children. HDL-C may be a sensitive indicator of serum lipids changes in SDB children.
authors: Department of Endocrinology, The Affiliated Hospital of Jiangsu University, China.
authors: Jing
authors: J
authors: Zong
authors: Yongyi
authors: Y
authors: Liu
authors: Yuanbo
authors: Y
authors: Huang
authors: Junjian
authors: J
authors: Chen
authors: Li
authors: L
authors: Gao
authors: Caili
authors: C
authors: Zhang
authors: Sijing
authors: S
authors: Dong
authors: Xuan
authors: X
authors: Chen
mesh_terms: D000234:Adenoids / Q000503:physiopathology*; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D014066:Palatine Tonsil / Q000503:physiopathology*; D017286:Polysomnography; D012044:Regression Analysis; D012891:Sleep Apnea Syndromes / Q000097:blood*; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids