title: The relationship between hyperuricemia and the risk of contrast-induced acute kidney injury after percutaneous coronary intervention in patients with relatively normal serum creatinine.
abstract: OBJECTIVE
  Hyperuricemia is a risk factor for contrast-induced acute kidney injury in patients with chronic kidney disease. This study evaluated the value of hyperuricemia for predicting the risk of contrast-induced acute kidney injury in patients with relatively normal serum creatinine who were undergoing percutaneous coronary interventions.
  
  
  RESULTS
  A total of 788 patients with relatively normal baseline serum creatinine (<1.5 mg/dL) undergoing percutaneous coronary intervention were prospectively enrolled and divided into a hyperuricemic group (n = 211) and a normouricemic group (n = 577). Hyperuricemia is defined as a serum uric acid level>7 mg/ dL in males and >6 mg/dL in females. The incidence of contrast-induced acute kidney injury was significantly higher in the hyperuricemic group than in the normouricemic group (8.1% vs. 1.4%, p<0.001). In-hospital mortality and the need for renal replacement therapy were significantly higher in the hyperuricemic group. According to a multivariate analysis (adjusting for potential confounding factors) the odds ratio for contrast-induced acute kidney injury in the hyperuricemic group was 5.38 (95% confidence interval, 1.99-14.58; p = 0.001) compared with the normouricemic group. The other risk factors for contrast-induced acute kidney injury included age >75 years, emergent percutaneous coronary intervention, diuretic usage and the need for an intra-aortic balloon pump.
  
  
  CONCLUSIONS
  Hyperuricemia was significantly associated with the risk of contrast-induced acute kidney injury in patients with relatively normal serum creatinine after percutaneous coronary interventions. This observation will help to generate hypotheses for further prospective trials examining the effect of uric acid-lowering therapies for preventing contrast-induced acute kidney injury.
authors: Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangdong Cardiovascular Institute, Department of Cardiology, Guangzhou, China.
authors: Yong
authors: Y
authors: Liu
authors: Ning
authors: N
authors: Tan
authors: Jiyan
authors: J
authors: Chen
authors: Yingling
authors: Y
authors: Zhou
authors: Liling
authors: L
authors: Chen
authors: Shiqun
authors: S
authors: Chen
authors: Zhujun
authors: Z
authors: Chen
authors: Liwen
authors: L
authors: Li
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000401:mortality; D000367:Age Factors; D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects; D003404:Creatinine / Q000097:blood*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000401:mortality / Q000652:urine; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D003287:Contrast Media; D003404:Creatinine