title: Novel imaging of atrial septal defects in isolated human hearts.
abstract: Within the adult population living with congenital heart defects, approximately 20 % have an atrial septal defect, which suggests that only 0.4-0.05 % of the entire adult population has an atrial septal defect (ASD). In patients with a left to right atrial shunt, treatments may include closure of the defect with a transcatheter device and/or surgical repair. From the perspective of a physician or engineer, it is vitally important to understand the anatomical nuances of such defects, not only to offer the most optimal treatment for the patient but also to call attention to the potential anatomy of ASDs which may go undetected. To do so, we reanimated two human hearts deemed not viable for transplant from 56-year-old and 68-year-old males. Neither patient history reported any heart conditions that would suggest an atrial defect, yet an ASD was found in each heart. Here, we present sets of images, videos, and 3D reconstructions that provide a clearer view of the anatomy of ASDs in functional human hearts. With an enhanced understanding of 3D functional aspects of ASDs, physicians can make improved decisions regarding treatment options and engineers can optimize device designs.
authors: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 54455, USA. howa0255@umn.edu
authors: Stephen A
authors: SA
authors: Howard
authors: Jason L
authors: JL
authors: Quill
authors: Michael D
authors: MD
authors: Eggen
authors: Cory M
authors: CM
authors: Swingen
authors: Paul A
authors: PA
authors: Iaizzo
mesh_terms: D000368:Aged; D054087:Atrial Septum / Q000473:pathology*; D002102:Cadaver; D006344:Heart Septal Defects, Atrial / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D055989:Septal Occluder Device