title: Leptin and adiponectin in cord blood from children of normal weight, overweight and obese mothers.
abstract: OBJECTIVE
  To study cord blood concentrations of adiponectin and leptin in children born by normal weight, overweight and obese mothers and to study these parameters in relation to a weight gain intervention programme for obese mothers.
  
  
  METHODS
  Ten millilitre cord blood was collected and analysed for leptin and adiponectin concentrations in children with gestational age >37 weeks born by 60 normal weight, 45 overweight and 145 obese mothers. 82 obese mothers took part in a weight gain intervention programme.
  
  
  RESULTS
  Concentrations of leptin and adiponectin were higher in cord blood from children of overweight and obese mothers compared with children of normal weight mothers (leptin: Md 13.2, 30, 3 and 90.2 ng/mL respectively, p < 0.001; adiponectin 35.9, 205.4, 213.8 ng/L p < 0.001). No differences were found between overweight and obese mothers. The weight gain intervention programme for obese pregnant women had significant effects on the weight gain during pregnancy but had no effects on cord blood serum concentrations of leptin and adiponectin.
  
  
  CONCLUSIONS
  Cord blood leptin and adiponectin concentrations were higher in children born by overweight or obese women compared with children of normal weight mothers. A weight gain intervention programme for obese pregnant women did not affect these results. Intrauterine exposition to high concentrations of leptin and adiponectin may play a role in weight development later in life.
authors: Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Obstetrics and Gynaecology in Linköping, County Council of Östergötland, Linköping, Sweden. jan.brynhildsen@lio.se
authors: Jan
authors: J
authors: Brynhildsen
authors: Gunilla
authors: G
authors: Sydsjö
authors: Marie
authors: M
authors: Blomberg
authors: Ing-Marie
authors: IM
authors: Claesson
authors: Elvar
authors: E
authors: Theodorsson
authors: Fredrik
authors: F
authors: Nyström
authors: Adam
authors: A
authors: Sydsjö
authors: Ann
authors: A
authors: Josefsson
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001835:Body Weight / Q000502:physiology*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005333:Fetus / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D020738:Leptin / Q000097:blood*; D009035:Mothers; D050177:Overweight / Q000503:physiopathology; D011446:Prospective Studies
chemical_list: D052242:Adiponectin; D020738:Leptin