title: Outcome of anti-PL12 positive patients with antisynthetase syndrome.
abstract: OBJECTIVE
  The aim of the present study was to assess the outcome in anti-PL12 patients with antisynthetase syndrome (ASS).
  
  
  METHODS
  The medical records of anti-PL12 (n=5) patients with ASS were retrospectively analyzed without prior selection. To exclude false-positive patients, we included patients who were successively tested positive for anti-PL12 antibody at least twice by immunodot and/or Western blot.
  
  
  RESULTS
  Anti-PL12 patients experienced: myositis (n=2), Raynaud's phenomenon (n=2), mechanic's hands (n=1), joint impairment (n=4), digestive involvement (n=2), and interstitial lung disease (ILD) (n=4). The two patients with myositis exhibited deterioration of muscle manifestations despite therapy. As regards outcome of ILD, patients developed resolution (n=1), stabilization (n=1) or deterioration (n=2) of pulmonary status. One patient died of pyogenic pneumonia.
  
  
  CONCLUSIONS
  Our series underscores that the presence of anti-PL12 antibody is associated with a particular phenotype of ASS characterized by: (1) less frequent although severe/steroid refractory myositis; (2) less common mechanic's hands and calcinosis cutis; (3) both frequent and severe ILD. Taken together, our findings suggest that PM/DM patients should routinely undergo the search for anti-PL12 antibody as this autoantibody appears to impact patients' prognosis. Furthermore, ILD patients with anti-PL12 antibody should routinely undergo clinical screening for underlying ASS.
authors: CHU Rouen, Institute for Biochemical Research, University of Rouen IFRMP, Department of Internal medicine, Inserm U 905, 76031 Rouen cedex, France. isabelle.marie@chu-rouen.fr
authors: Isabelle
authors: I
authors: Marie
authors: Séverine
authors: S
authors: Josse
authors: Olivier
authors: O
authors: Decaux
authors: Stéphane
authors: S
authors: Dominique
authors: Cédric
authors: C
authors: Landron
authors: Pascal
authors: P
authors: Roblot
authors: Stéphane
authors: S
authors: Jouneau
authors: Olivier
authors: O
authors: Vittecoq
authors: Fabienne
authors: F
authors: Jouen
mesh_terms: D000412:Alanine-tRNA Ligase / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies; D000412:Alanine-tRNA Ligase