title: Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis.
abstract: The aim of the current study was to investigate the therapeutic effect of Tripterygium wilfordii Hook F multiglycosides (TWG) on gut barrier dysfunction in rats with acute necrotizing pancreatitis (ANP). ANP was induced in rats using 3.5% sodium taurocholate. The rats were divided into 3 groups: the sham operation (SO), ANP and ANP+TWG groups. Biochemical and pathological change of pancreatic tissue and ileal mucosa, bacterial cultures and the survival rate were measured following surgery and treatment. TWG treatment significantly decreased amylase and lipase activities and plasma endotoxin and D-lactate levels. Edema and inflammation in the pancreas and ileal mucosa were alleviated. Positive bacterial cultures were significantly reduced. The survival rate of the rats in the ANP+TWG group was higher than that of the rats in the ANP group. TWG treatment showed beneficial effects by protecting the pancreas from bacterial infection caused by gut barrier dysfunction and improving the outcomes of the rats with ANP.
authors: Department of Surgery, Huashan Hospital, Fudan University, Shanghai,  P.R. China.
authors: Jie
authors: J
authors: Wang
authors: Gang
authors: G
authors: Wu
authors: Baojin
authors: B
authors: Ma
authors: Jianhua
authors: J
authors: Wu
authors: Duan
authors: D
authors: Cai
keywords: acute necrotizing pancreatitis; gut barrier dysfunction; therapy; tripterygium wilfordii hook f multiglycosides