title: [Biological monitoring of exposure to carcinogenic metallic elements and polycyclic aromatic hydrocarbons in four secondary metallurgical sectors].
abstract: This cross-sectional study was aimed at evaluating in a large sample of male foundry workers the current exposure levels to carcinogenic compounds, including metallic elements [arsenic (As), beryllium (Be), cadmium (Cd), chromium (Cr), nickel (Ni)] and aromatic polycyclic hydrocarbons (PAH) by a biological monitoring approach, using validated biomarkers of exposure. Workers were recruited from 15 aluminium, copper alloy, electric steel and cast iron foundries and provided an end-of-shift urine sample to determine urinary concentrations of As, Be, Cd, Cr, Ni and 1-hydroxypyrene (1-OHP). Metallic elements were determined either by inductively coupled plasma mass spectrometry (Be, Cd and Cr) or by atomic absorption spectrometry (As, Ni), whereas 1-OHP was determined by high pressure liquid chromatography with fluorimetric detection. Most of the determinations fell within the laboratory's reference values. Age and lifestyle habits (smoking, alcohol, diet) played a significant interfering role.
authors: Dipartimento di Medicina Sperimentale ed Applicata, Sezione di Medicina del Lavoro ed Igiene Industriale, Università degli Studi di Brescia, Brescia, Italy. depalma@med.unibs.it
authors: G
authors: G
authors: De Palma
authors: A
authors: A
authors: Corsini
authors: E
authors: E
authors: Gilberti
authors: V
authors: V
authors: Gabusi
authors: G
authors: G
authors: Tagliani
authors: C
authors: C
authors: Tomasi
authors: A
authors: A
authors: Gandellini
authors: P
authors: P
authors: Apostoli
mesh_terms: D002273:Carcinogens; D003430:Cross-Sectional Studies; D004784:Environmental Monitoring; D006801:Humans; D008297:Male; D008669:Metallurgy; D008670:Metals / Q000009:adverse effects* / Q000652:urine; D016273:Occupational Exposure / Q000009:adverse effects*; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects* / Q000652:urine
chemical_list: D002273:Carcinogens; D008670:Metals; D011084:Polycyclic Aromatic Hydrocarbons