title: Assessment of oxidative, inflammatory, and fibrinolytic biomarkers and DNA strand breakage in hypercholesterolemia.
abstract: The aim of this study was to assess the levels of oxidative, inflammatory, and fibrinolytic biomarkers as well as DNA strand breakage in hypercholesterolemic subjects. Fasting glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, uric acid, total protein, albumin, apolipoprotein (Apo) A, Apo B, advanced oxidation protein products (AOPP), increased ischemia-modified albumin (IMA), -SH, NOx, IL-6, and D-dimer levels were assessed, and DNA strand breakage was evaluated using comet assay in 38 patients with hypercholesterolemia and 20 healthy controls. Total cholesterol, triglycerides, LDL cholesterol, Apo A, Apo B, AOPP, IMA, IL-6, and D-dimer concentrations were significantly higher in subjects with hypercholesterolemia. However, NOx and plasma -SH group concentrations were lower in hypercholesterolemic subjects, while no significant differences were observed with respect to DNA strand breakage between the two groups. Hypercholesterolemia is related to oxidative stress and inflammation. Accordingly, AOPP concentration was higher in subjects with hypercholesterolemia, and we speculate that AOPP can reflect the enhancement of protein oxidation and inflammation.
authors: Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors: Renata
authors: R
authors: da Silva Pereira
authors: Etiane
authors: E
authors: Tatsch
authors: Guilherme Vargas
authors: GV
authors: Bochi
authors: Helena
authors: H
authors: Kober
authors: Thiago
authors: T
authors: Duarte
authors: Greice Franciele Feyh
authors: GF
authors: dos Santos Montagner
authors: José Edson Paz
authors: JE
authors: da Silva
authors: Marta Maria Medeiros Frescura
authors: MM
authors: Duarte
authors: Ivana Beatrice Mânica
authors: IB
authors: da Cruz
authors: Rafael Noal
authors: RN
authors: Moresco
mesh_terms: D062107:Advanced Oxidation Protein Products / Q000097:blood; D015415:Biomarkers; D001798:Blood Proteins / Q000032:analysis*; D053960:DNA Breaks; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000235:genetics*; D007249:Inflammation / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers; D001798:Blood Proteins; D008055:Lipids