title: CXCL9/Mig mediates T cells recruitment to valvular tissue lesions of chronic rheumatic heart disease patients.
abstract: Rheumatic fever (RF) is an autoimmune disease triggered by Streptococcus pyogenes infection frequently observed in infants from developing countries. Rheumatic heart disease (RHD), the major sequel of RF, leads to chronic inflammation of the myocardium and valvular tissue. T cells are the main population infiltrating cardiac lesions; however, the chemokines that orchestrate their recruitment are not clearly defined. Here, we investigated the expression of chemokines and chemokine receptors in cardiac tissue biopsies obtained from chronic RHD patients. Our results showed that CCL3/MIP1α gene expression was upregulated in myocardium while CCL1/I-309 and CXCL9/Mig were highly expressed in valvular tissue. Auto-reactive T cells that infiltrate valvular lesions presented a memory phenotype (CD4(+)CD45RO(+)) and migrate mainly toward CXCL9/Mig gradient. Collectively, our results show that a diverse milieu of chemokines is expressed in myocardium and valvular tissue lesions and emphasize the role of CXCL9/Mig in mediating T cell recruitment to the site of inflammation in the heart.
authors: Heart Institute, School of Medicine, University of São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 44, 05403-000, São Paulo, SP, Brazil.
authors: Kellen C
authors: KC
authors: Faé
authors: Selma A
authors: SA
authors: Palacios
authors: Luciana G
authors: LG
authors: Nogueira
authors: Sandra E
authors: SE
authors: Oshiro
authors: Léa M F
authors: LM
authors: Demarchi
authors: Angelina M B
authors: AM
authors: Bilate
authors: Pablo M A
authors: PM
authors: Pomerantzeff
authors: Carlos
authors: C
authors: Brandão
authors: Petronio G
authors: PG
authors: Thomaz
authors: Maxwell
authors: M
authors: dos Reis
authors: Roney
authors: R
authors: Sampaio
authors: Ana C
authors: AC
authors: Tanaka
authors: Edecio
authors: E
authors: Cunha-Neto
authors: Jorge
authors: J
authors: Kalil
authors: Luiza
authors: L
authors: Guilherme
mesh_terms: D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D054402:Chemokine CCL1 / Q000096:biosynthesis / Q000276:immunology; D054405:Chemokine CCL3 / Q000096:biosynthesis / Q000276:immunology; D054370:Chemokine CXCL9 / Q000096:biosynthesis / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005355:Fibrosis; D006351:Heart Valves / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000276:immunology* / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000276:immunology; D012213:Rheumatic Fever / Q000276:immunology / Q000382:microbiology; D012214:Rheumatic Heart Disease / Q000276:immunology*; D013297:Streptococcus pyogenes; D055815:Young Adult
chemical_list: C065971:CCL1 protein, human; C515429:CCL3 protein, human; C080810:CXCL9 protein, human; D054402:Chemokine CCL1; D054405:Chemokine CCL3; D054370:Chemokine CXCL9