title: Three new lanostanoid triterpenes from the fruiting bodies of Ganoderma tropicum.
abstract: Three new lanostanoid triterpenes, 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid (1), 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid methyl ester (2), and 3β,15β-dihydroxy-7,11,23-trioxo-lanost-8,16-dien-26-oic acid methyl ester (3) were isolated from the EtOAc extract of the fruiting bodies of Ganoderma tropicum. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) of these isolates was evaluated and compound 2 exhibited definite inhibitory activity against AChE.
authors: MOA Key Laboratory of Tropical Crop Biology and Genetic Resources Utilization, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
authors: Li-Li
authors: LL
authors: Hu
authors: Qing-Yun
authors: QY
authors: Ma
authors: Sheng-Zhuo
authors: SZ
authors: Huang
authors: Zhi-Kai
authors: ZK
authors: Guo
authors: Hai-Xia
authors: HX
authors: Ma
authors: Jian-Chun
authors: JC
authors: Guo
authors: Hao-Fu
authors: HF
authors: Dai
authors: You-Xing
authors: YX
authors: Zhao
mesh_terms: D018680:Cholinergic Antagonists / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032902:Ganoderma / Q000737:chemistry*; D007810:Lanosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: C582378:3beta,15beta-dihydroxy-7,11,23-trioxo-lanost-8,16-dien-26-oic acid methyl ester; C582376:3beta,7beta,15beta-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid; C582377:3beta,7beta,15beta-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid methyl ester; D018680:Cholinergic Antagonists; D007810:Lanosterol