title: Freeze-dried jaboticaba peel powder improves insulin sensitivity in high-fat-fed mice.
abstract: The peel of the native Brazilian fruit jaboticaba is rich in anthocyanins, which are known for their anti-obesity effects in animal models. The aim of the present study was to evaluate the effects of freeze-dried jaboticaba peel powder (FDJPP) on a number of metabolic parameters in a model of diet-induced obesity. Mice (n 8 per group) were initially fed on a high-fat diet (HFD, 35% w/w) for 4 weeks and then switched to a HFD supplemented with FDJPP (1, 2 or 4% w/w) for an additional 6 weeks. Energy intake, weight loss, glucose tolerance, insulin resistance and lipid profile were determined, and the results were evaluated using ANOVA and Tukey’s tests. The FDJPP exerted no protective effect on HFD-induced weight gain, hyperleptinaemia and glucose intolerance. However, the supplementation was effective to reduce insulin resistance, as evidenced in the insulin tolerance test, and subsequently confirmed by improved signal transduction through the insulin receptor/insulin receptor substrate-1/Akt/forkhead box protein pathway and by the attenuation of HFD-induced inflammation in the liver, verified by lower expressions of IL-1b and IL-6 and decreased phosphorylated IkB-a protein levels in all jaboticaba-treated mice. These results suggest that FDJPP may exert a protective role against obesity-associated insulin resistance.
authors: Department of Food and Nutrition, Faculty of Food Engineering, University of Campinas (UNICAMP), Monteiro Lobato 80, 13083-862 Campinas, São Paulo, Brazil.
authors: Nathalia R V
authors: NR
authors: Dragano
authors: Anne y Castro
authors: Ay
authors: Marques
authors: Dennys E C
authors: DE
authors: Cintra
authors: Carina
authors: C
authors: Solon
authors: Joseane
authors: J
authors: Morari
authors: Alice V
authors: AV
authors: Leite-Legatti
authors: Lício A
authors: LA
authors: Velloso
authors: Mário R
authors: MR
authors: Maróstica-Júnior
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology / Q000627:therapeutic use; D019440:Anti-Obesity Agents / Q000494:pharmacology / Q000627:therapeutic use; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements; D005638:Fruit; D018149:Glucose Intolerance; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D027822:Myrtaceae / Q000737:chemistry; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D011208:Powders; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000872:Anthocyanins; D019440:Anti-Obesity Agents; D007328:Insulin; D020738:Leptin; D028321:Plant Preparations; D011208:Powders; D011972:Receptor, Insulin