title: Maternal serum retinol-binding protein-4 at 11-13 weeks' gestation in normal and pathological pregnancies.
abstract: OBJECTIVE
  To examine maternal serum levels of retinol-binding protein-4 (RBP4) at 11-13 weeks' gestation in normal and pathological pregnancies.
  
  
  METHODS
  Serum RBP4 at 11-13 weeks was measured in 480 singleton pregnancies, including 240 with normal outcome, 60 that subsequently developed preeclampsia (PE), 60 that developed gestational diabetes mellitus (GDM), 60 that delivered large for gestational age (LGA) neonates and 60 that delivered small (SGA) neonates. The values in each adverse pregnancy outcome group were compared to those of normal pregnancies.
  
  
  RESULTS
  Serum concentration of RBP4 was not significantly different in women who subsequently developed PE (p=0.925), or GDM (p=0.074), or had pregnancies that led to delivery to SGA (p=0.085), LGA (p=0.332) neonates.
  
  
  CONCLUSIONS
  Maternal serum RBP4 in the first trimester is not significantly altered in pathological pregnancies.
authors: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
authors: Surabhi
authors: S
authors: Nanda
authors: George
authors: G
authors: Nikoletakis
authors: Desislava
authors: D
authors: Markova
authors: Leona C Y
authors: LC
authors: Poon
authors: Kypros H
authors: KH
authors: Nicolaides
mesh_terms: D000328:Adult; D001724:Birth Weight; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011225:Pre-Eclampsia / Q000097:blood / Q000503:physiopathology; D011247:Pregnancy / Q000097:blood*; D011248:Pregnancy Complications / Q000097:blood* / Q000503:physiopathology; D011261:Pregnancy Trimester, First; D011254:Pregnancy in Diabetics / Q000097:blood / Q000503:physiopathology; D011446:Prospective Studies; D012016:Reference Values; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*
chemical_list: C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma