title: Propofol-interrupted tinnitus later suppressed by amantadine: a case-report.
abstract: Tinnitus is a frequent condition without consistently effective remediation. Mr V. was a 64 year old man with Behcet's disease, a generalized systemic relapsing vasculitis. Tinnitus appeared in 1998 and he had been both aware and distressed by his tinnitus 80% of his awake time. After his last colonoscopic examination, he mentioned a transient interruption of his tinnitus. Mr V. only received propofol, an anesthesic drug that selectively down-regulates glutamatergic synaptic transmission. Amantadine, another glutamate antagonist, was later prescribed and durably suppressed tinnitus. Systematically inquiry about post-anesthesia effects on tinnitus may help decide if amantadine may be tried on an individual basis.
authors: Faculty of Medicine, Paris Descartes University, Paris, France. r.dardennes@ch‐sainte‐anne.fr
authors: Roland
authors: R
authors: Dardennes
authors: Nebal
authors: N
authors: Al Anbar
authors: Frédéric
authors: F
authors: Rouillon
mesh_terms: D000547:Amantadine / Q000627:therapeutic use*; D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D001528:Behcet Syndrome; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000627:therapeutic use*; D014012:Tinnitus / Q000188:drug therapy*
chemical_list: D018686:Anesthetics, Intravenous; D018691:Excitatory Amino Acid Antagonists; D000547:Amantadine; D015742:Propofol