title: Hepatoprotective activity of methanol extract of Melastoma malabathricum leaf in rats.
abstract: The present study aimed to determine the hepatoprotective activity of a methanol extract of Melastoma malabathricum leaves (MEMM) using two established rat models. Ten groups of rats (n=6) were given a once-daily administration of 10% dimethyl sulfoxide (negative control), 200 mg/kg silymarin (positive control), or MEMM (50, 250, or 500 mg/kg) for 7 days followed by induction of hepatotoxicity either using paracetamol or carbon tetrachloride. Blood samples and livers were collected for biochemical and microscopic analysis. Based on the results obtained, MEMM exhibited a significant (p<0.05) hepatoprotective activity against both inducers, as indicated by an improvement in the liver function test. These observations were supported by the histologic findings. In conclusion, M. malabathricum leaves possessed hepatoprotective activity, which could be linked to their phytochemical constituents and antioxidant activity; this therefore requires further in-depth studies.
authors: Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
authors: Farah Hidayah
authors: FH
authors: Kamisan
authors: Farhana
authors: F
authors: Yahya
authors: Noor Aisyah
authors: NA
authors: Ismail
authors: Syafawati Shamsahal
authors: SS
authors: Din
authors: Siti Syariah
authors: SS
authors: Mamat
authors: Zalina
authors: Z
authors: Zabidi
authors: Wan Noraziemah Wan
authors: WN
authors: Zainulddin
authors: Norhafizah
authors: N
authors: Mohtarrudin
authors: Hadijah
authors: H
authors: Husain
authors: Zuraini
authors: Z
authors: Ahmad
authors: Zainul Amiruddin
authors: ZA
authors: Zakaria
mesh_terms: D000818:Animals; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000188:drug therapy / Q000517:prevention & control; D008297:Male; D035322:Melastomataceae / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010936:Plant Extracts; D020011:Protective Agents