title: Is the neck circumference an emergent predictor for inflammatory status in obese adults?
abstract: BACKGROUND
  Plasminogen Activator Inhibitor 1 (PAI-1) is a prothrombotic adipokine involved in the coagulation cascade and fibrinolysis that associated with proinflammatory adipokines may increase the risk related to obesity. Anthropometric measures are commonly used in clinical practice and, currently, neck circumference (NC) has been used as a marker of cardiovascular risk that can favour inflammatory factors.
  
  
  OBJECTIVE
  To verify the possible correlations between prothrombotic and pro/anti-inflammatory markers with anthropometric measurements in obese.
  
  
  METHODS
  A total of 43 obese adults were enrolled. The variables include body mass, stature, body mass index (BMI), NC, chest circumference (CC), abdominal circumference (AC), hip circumference (HC), blood pressure and blood collection used to assess the level of adipokines.
  
  
  RESULTS
  The sample was stratified by BMI. PAI-1 levels were positively correlated with body mass (r=0.31, p=0.04), NC (r=0.43, p=0.004), CC (r=0.40, p=0.004), AC (r=0.37, p=0.01), diastolic blood pressure (r=0.35, p=0.03), leptin/adiponectin ratio (r=0.36, p=0.01) and negatively correlated with adiponectin (r=-0.34, p=0.02). In stepwise multiple linear regression analysis, NC showed to be an independent predictor to PAI-1 when adjusted for gender and BMI, according to the age (β=0.47, p=0.02 and β=0.42, p=0.02 respectively).
  
  
  CONCLUSIONS
  In conclusion, NC could be suggested as an independent predictor higher PAI-1. This association can be a new screening of persons at an enhanced cardiovascular risk and inflammation in this obese population, so useful in clinical practice.
authors: Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo - UNIFESP - Santos (SP), Brazil. gi_jamar@hotmail.com
authors: G
authors: G
authors: Jamar
authors: L P
authors: LP
authors: Pisani
authors: L M
authors: LM
authors: Oyama
authors: C
authors: C
authors: Belote
authors: D C L
authors: DC
authors: Masquio
authors: V A
authors: VA
authors: Furuya
authors: J P
authors: JP
authors: Carvalho-Ferreira
authors: S G
authors: SG
authors: Andrade-Silva
authors: A R
authors: AR
authors: Dâmaso
authors: D A
authors: DA
authors: Caranti
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000328:Adult; D000886:Anthropometry / Q000379:methods*; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology; D020738:Leptin / Q000378:metabolism; D008297:Male; D009333:Neck / Q000473:pathology*; D009765:Obesity / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism
chemical_list: D052242:Adiponectin; D020738:Leptin; D017395:Plasminogen Activator Inhibitor 1