title: [Macroglobulin signaling system].
abstract: This review will focus on the systematization of knowledge about structure of macroglobulin signaling system, which includes macroglobulin family proteins (alpha-2-macroglobulin, alpha-2-glycoprotein, pregnancy associated plasma protein A), their receptors (LRP, grp78), ligands (proteinases, cytokines, hormones, lipids, et al.) transforming and transcriptional factors for regulation of macroglobulins synthesis. After reviewing the functions of macroglobulin signaling system, and mechanisms of their realization, we discuss the complex and significant role of this system in different physiological and pathological processes.
authors: N A
authors: NA
authors: Zorin
authors: V N
authors: VN
authors: Zorina
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D000091342:Endoplasmic Reticulum Chaperone BiP; D005260:Female; D006360:Heat-Shock Proteins / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008259:Macroglobulins / Q000378:metabolism*; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D016207:Cytokines; D000091342:Endoplasmic Reticulum Chaperone BiP; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins; D006728:Hormones; D008024:Ligands; D008259:Macroglobulins; D010447:Peptide Hydrolases