title: Periodontal repair in dogs: space-provision supports alveolar bone and cementum formation.
abstract: OBJECTIVE
  Clinical criteria for periodontal wound healing/regeneration include wound stability, space-provision and conditions for primary intention healing. However, wound stability/space-provision may be difficult to obtain in non-contained periodontal defects. The objective of this study was to; using a limited, space-providing device as a conduit, evaluate a concept of space-provision sans tissue occlusion for periodontal wound healing/regeneration.
  
  
  METHODS
  Bilateral, critical-size, supraalveolar, periodontal defects were created in eight young adult Beagle dogs. One jaw quadrant received a limited, space-providing titanium mesh device, the contra-lateral jaw quadrant served as sham-surgery control followed by submerged wound closure for primary intention healing. The animals were euthanized at 8 weeks for histometric analysis of the surgical sites.
  
  
  RESULTS
  Clinical healing was generally uneventful; minor late exposures observed for some defects. Experimental sites exhibited significantly enhanced mean (±SE) bone and cementum regeneration compared with control (1.10 ± 0.20 and 1.32 ± 0.10 mm versus 0.34 ± 0.18 and 0.66 ± 0.15 mm; p < 0.01). A cellular mixed (extrinsic/intrinsic) fibre cementum and functionally oriented collagen fibres were routinely observed. Wound exposures were significantly associated with reduced bone formation (p < 0.05).
  
  
  CONCLUSIONS
  Using a limited, space-providing device to support periodontal wound healing/regeneration appears a promising clinical approach for non-contained periodontal defects.
authors: Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, ROC. d1121@mail.ndmctsgh.edu.tw
authors: Hsien-Chung
authors: HC
authors: Chiu
authors: E-Chin
authors: EC
authors: Shen
authors: Shu-Jiun
authors: SJ
authors: Lin
authors: Cristiano
authors: C
authors: Susin
authors: Ulf M E
authors: UM
authors: Wikesjö
authors: Earl
authors: E
authors: Fu
mesh_terms: D000540:Alveolar Ridge Augmentation; D000818:Animals; D001861:Bone Regeneration; D025021:Cementogenesis; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation / Q000379:methods*; D008297:Male; D010513:Periodontal Ligament / Q000502:physiology*; D013027:Space Maintenance, Orthodontic / Q000295:instrumentation*; D013526:Surgical Mesh