title: Expression of inflammation-mediated cluster of genes as a new marker of canine mammary malignancy.
abstract: Because canine mammary tumours constitute a serious clinical problem and there are no good prognostic markers (only histopathological variables are used), the aim of the presented study was to find new malignancy markers as well as to identify intracellular pathways and biological processes characteristic for canine mammary malignancy. We compared gene expression of the most malignant mammary tumours (poorly differentiated cancers of the 3rd grade of malignancy) with less malignant tumours (well differentiated cancers of the 1st grade of malignancy). The results of our study indicated that in dogs the number of tumour-infiltrating myeloid cells or expression of myeloid-specific antigens by cancer cells is related to the cancer progression and may constitute a new marker of malignancy, however further studies in this field are required.
authors: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences-WULS, Nowoursynowska 159, 02-776 Warsaw, Poland.
authors: K M
authors: KM
authors: Pawłowski
authors: A
authors: A
authors: Homa
authors: M
authors: M
authors: Bulkowska
authors: K
authors: K
authors: Majchrzak
authors: T
authors: T
authors: Motyl
authors: M
authors: M
authors: Król
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics*; D004283:Dog Diseases / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D007150:Immunohistochemistry / Q000662:veterinary; D007249:Inflammation / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D060787:Neoplasm Grading; D020411:Oligonucleotide Array Sequence Analysis / Q000662:veterinary; D012334:RNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary
chemical_list: D014408:Biomarkers, Tumor; D012334:RNA, Neoplasm