title: [Effect of soy protein on expression of SREBP-1 in rats].
abstract: OBJECTIVE
  To explore the effects of soy protein on the expression of SREBP-1,2 in rats feeding normal and high-fat diet.
  
  
  METHODS
  Forty eight Sprague-Dawley SPF class rats were randomly divided into 4 groups matched by body weight, soy protein group, casein group, soy protein-high fat group, casein-high fat group. The experiment diets were fed for 28 d. Then the rats were sacrificed off cervical, determined serum levels of homone and the level of gene expression.
  
  
  RESULTS
  The concentration of serum insulin and the ratio of insulin/glucagon in the soy protein group were significantly lower than that of the casein group ((54.1 +/- 10.7) vs (63.5 +/- 16.9) pmol/L, P < 0.05, (2.33 +/- 0.75) vs (3.21 +/- 1.41), P < 0.05), the concentration of serum insulin and the ratio of insulin/glucagon in the soy protein high-fat group were significantly lower than that of the casein high-fat group ((46.3 +/- 9.6) vs (50.4 +/- 10.1) pmol/L, P < 0.05, (1.53 +/- 0.72) vs (2.92 +/-1.23), P < 0.05). The expression of SREBP-1,2 in soy protein group and soy protein high-fat group were significantly lower than that in casein group and casein high-fat group. The protein expression of SREBP-1 in soy protein group and soy protein high-fat group were significantly lower than that in casein group and casein high-fat group.
  
  
  CONCLUSIONS
  Dietary soy protein intake may modulate serum lipid levels through influence the insulin level then infulence the expression of SREBP-1,2 mRNA.
authors: Department of Food Science, Guangdong Food and Drug Vocational Colleage, Guangzhou 510520, China. malili198015@yahoo.com.cn
authors: Lili
authors: L
authors: Ma
authors: Guiyuan
authors: G
authors: Ji
authors: Zhuoqin
authors: Z
authors: Jiang
mesh_terms: D000818:Animals; D005260:Female; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D030262:Soybean Proteins / Q000008:administration & dosage* / Q000494:pharmacology*; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D007328:Insulin; D008055:Lipids; D012333:RNA, Messenger; D030262:Soybean Proteins; C497389:Srebf1 protein, rat; D051780:Sterol Regulatory Element Binding Protein 1