title: Prenatal maternal mood is associated with altered diurnal cortisol in adolescence.
abstract: BACKGROUND
  Experimental animal work shows that prenatal stress has a persisting effect on the hypothalamic-pituitary-adrenal (HPA) axis of offspring. The implications of these findings for human health and development are not yet clear.
  
  
  METHODS
  The data are based on the ALSPAC cohort, a prospective longitudinal study of a community sample that has followed mothers and children from pregnancy. When the children were aged 15 years, diurnal cortisol samples were collected at wake-up, 30 min post-awakening and at afternoon and evening times on up to three consecutive days on n=889 adolescents. Diurnal cortisol was predicted from prenatal anxiety and depression, obstetric, life-style, socio-demographic, and postnatal covariates.
  
  
  RESULTS
  Multilevel model analysis indicated that maternal prenatal anxiety was associated with a modest alteration of diurnal cortisol, indexed by a reduced cortisol awakening response and flatter diurnal slope. The effects were independent of psychosocial and obstetric covariates and measures of maternal postnatal anxiety; effects were similar for prenatal maternal depression. There was no association between adolescent cortisol and paternal prenatal anxiety.
  
  
  CONCLUSIONS
  There are small but persisting associations between maternal prenatal mood and diurnal cortisol in the child that persist into adolescence and may constitute a programming effect.
authors: McGill University, Montreal, Canada.
authors: Kieran J
authors: KJ
authors: O'Donnell
authors: Vivette
authors: V
authors: Glover
authors: Jennifer
authors: J
authors: Jenkins
authors: Dillon
authors: D
authors: Browne
authors: Yoav
authors: Y
authors: Ben-Shlomo
authors: Jean
authors: J
authors: Golding
authors: Thomas G
authors: TG
authors: O'Connor
mesh_terms: D000293:Adolescent / Q000502:physiology*; D000339:Affect; D001007:Anxiety / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000502:physiology*; D003863:Depression / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000196:embryology* / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000196:embryology* / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology* / Q000523:psychology; D011297:Prenatal Exposure Delayed Effects; D012463:Saliva / Q000737:chemistry; D012494:Sampling Studies; D012636:Secretory Rate; D012720:Severity of Illness Index; D012959:Socioeconomic Factors; D014851:Wakefulness
chemical_list: D006854:Hydrocortisone
keywords: ALSPAC; Cortisol; Developmental programming; HPA axis; Prenatal anxiety