title: Using synchrotron radiation angiography with a highly sensitive detector to identify impaired peripheral perfusion in rat pulmonary emphysema.
abstract: Owing to limitations in spatial resolution and sensitivity, it is difficult for conventional angiography to detect minute changes of perfusion in diffuse lung diseases, including pulmonary emphysema (PE). However, a high-gain avalanche rushing amorphous photoconductor (HARP) detector can give high sensitivity to synchrotron radiation (SR) angiography. SR angiography with a HARP detector provides high spatial resolution and sensitivity in addition to time resolution owing to its angiographic nature. The purpose of this study was to investigate whether this SR angiography with a HARP detector could evaluate altered microcirculation in PE. Two groups of rats were used: group PE and group C (control). Transvenous SR angiography with a HARP detector was performed and histopathological findings were compared. Peak density of contrast material in peripheral lung was lower in group PE than group C (p < 0.01). The slope of the linear regression line in scattering diagrams was also lower in group PE than C (p < 0.05). The correlation between the slope and extent of PE in histopathology showed significant negative correlation (p < 0.05, r = 0.61). SR angiography with a HARP detector made it possible to identify impaired microcirculation in PE by means of its high spatial resolution and sensitivity.
authors: Graduate School of Comprehensive Human Science, Department of Thoracic and Cardiovascular Surgery, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
authors: Hiromichi
authors: H
authors: Ito
authors: Shonosuke
authors: S
authors: Matsushita
authors: Kazuyuki
authors: K
authors: Hyodo
authors: Yukio
authors: Y
authors: Sato
authors: Yuzuru
authors: Y
authors: Sakakibara
mesh_terms: D000792:Angiography / Q000379:methods*; D000818:Animals; D003287:Contrast Media; D008168:Lung / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D008833:Microcirculation; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging*; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity; D017356:Synchrotrons
chemical_list: D003287:Contrast Media
keywords: HARP detector; pulmonary emphysema; pulmonary microcirculation; sensitivity; synchrotron radiation angiography