title: Otherwise inert reaction of sulfonamides/carboxamides with formamides via proton transfer-enhanced reactivity.
abstract: NBS-mediated addition-elimination reaction of sulfonamides/carboxamides and formamides afforded N-sulfonylamidines and N-formylarylamides, respectively, depending on the different mechanism of elimination. Hydrogen bond-induced proton transfer leads to enhanced reactivities and was proposed as the key driving force for the reaction to take place. The protocol demonstrates the possibility of constructing chemical bonds based on a proton transfer strategy induced by noncovalent hydrogen bond interaction.
authors: Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors: Zaihai
authors: Z
authors: Niu
authors: Shaoxia
authors: S
authors: Lin
authors: Zhiyong
authors: Z
authors: Dong
authors: Hao
authors: H
authors: Sun
authors: Fushun
authors: F
authors: Liang
authors: Jingping
authors: J
authors: Zhang
mesh_terms: D005559:Formamides / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D011522:Protons; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D005559:Formamides; D011522:Protons; D013449:Sulfonamides