title: Decrease recurrence rate of condylomata acuminata by photodynamic therapy combined with CO2 laser in mainland China: a meta-analysis.
abstract: BACKGROUND
  Condylomata acuminata (CA) are caused by human papillomavirus. Most conventional therapies for CA have high recurrence rate.
  
  
  OBJECTIVE
  To compare the recurrence rate of 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser and CO2 laser alone for CA treatment in mainland China.
  
  
  METHODS
  In this meta-analysis, 2,048 cases of CA from 22 articles were divided into two groups. The treatment group was treated by using ALA-PDT combined with CO2 laser, and CO2 laser alone was applied in the control group. The recurrence rate of the two groups was calculated and compared.
  
  
  RESULTS
  The recurrence rate was 42.67% (451/1,057) in the control group and 10.29% (102/991) in the treatment group, with a significant statistical difference between the two groups (χ(2) = 271.98, p < 0.0001).
  
  
  CONCLUSIONS
  ALA-PDT combined with CO2 laser was more effective in decreasing the recurrence rate of CA compared with CO2 laser alone. It might offer a wide clinical application for CA treatment.
authors: Department of Pathology, Basic Medical Science College, Harbin Medical University, Harbin, China.
authors: Xiaoling
authors: X
authors: Zhu
authors: Hongxiao
authors: H
authors: Chen
authors: Longfeng
authors: L
authors: Cai
authors: Zhiming
authors: Z
authors: Yu
authors: Limin
authors: L
authors: Cai
mesh_terms: D002681:China; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D054020:Lasers, Gas / Q000706:statistics & numerical data*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D055502:Secondary Prevention
chemical_list: D017319:Photosensitizing Agents