title: Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder.
abstract: Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.
authors: Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands. m.figee@amc.nl
authors: Martijn
authors: M
authors: Figee
authors: Judy
authors: J
authors: Luigjes
authors: Ruud
authors: R
authors: Smolders
authors: Carlos-Eduardo
authors: CE
authors: Valencia-Alfonso
authors: Guido
authors: G
authors: van Wingen
authors: Bart
authors: B
authors: de Kwaasteniet
authors: Mariska
authors: M
authors: Mantione
authors: Pieter
authors: P
authors: Ooms
authors: Pelle
authors: P
authors: de Koning
authors: Nienke
authors: N
authors: Vulink
authors: Nina
authors: N
authors: Levar
authors: Lukas
authors: L
authors: Droge
authors: Pepijn
authors: P
authors: van den Munckhof
authors: P Richard
authors: PR
authors: Schuurman
authors: Aart
authors: A
authors: Nederveen
authors: Wim
authors: W
authors: van den Brink
authors: Ali
authors: A
authors: Mazaheri
authors: Matthijs
authors: M
authors: Vink
authors: Damiaan
authors: D
authors: Denys
mesh_terms: D000328:Adult; D003342:Corpus Striatum / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology*; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology