title: Reducing Poisson noise and baseline drift in X-ray spectral images with bootstrap Poisson regression and robust nonparametric regression.
abstract: X-ray spectral imaging provides quantitative imaging of trace elements in a biological sample with high sensitivity. We propose a novel algorithm to promote the signal-to-noise ratio (SNR) of x-ray spectral images that have low photon counts. Firstly, we estimate the image data area that belongs to the homogeneous parts through confidence interval testing. Then, we apply the Poisson regression through its maximum likelihood estimation on this area to estimate the true photon counts from the Poisson noise corrupted data. Unlike other denoising methods based on regression analysis, we use the bootstrap resampling method to ensure the accuracy of regression estimation. Finally, we use a robust local nonparametric regression method to estimate the baseline and subsequently subtract it from the x-ray spectral data to further improve the SNR of the data. Experiments on several real samples show that the proposed method performs better than some state-of-the-art approaches to ensure accuracy and precision for quantitative analysis of the different trace elements in a standard reference biological sample.
authors: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
authors: Feng
authors: F
authors: Zhu
authors: Binjie
authors: B
authors: Qin
authors: Weiyue
authors: W
authors: Feng
authors: Huajian
authors: H
authors: Wang
authors: Shaosen
authors: S
authors: Huang
authors: Yisong
authors: Y
authors: Lv
authors: Yong
authors: Y
authors: Chen
mesh_terms: D000818:Animals; D002417:Cattle; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008099:Liver / Q000166:cytology; D057054:Molecular Imaging / Q000379:methods*; D016012:Poisson Distribution; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D013552:Swine; D014965:X-Rays