title: Serum ischemia-modified albumin level and its association with cardiovascular risk factors in obese children and adolescents.
abstract: BACKGROUND
  Serum ischemia modified albumin (IMA) levels have been previously studied and found to correlate with some anthropometric and laboratory measurements in adult obesity. IMA had not been studied in obese children and adolescents.
  
  
  OBJECTIVE
  The aim of the study is to analyze serum IMA levels and to evaluate their correlation with cardiovascular risk factors in obese children and adolescents with and without metabolic syndrome (MS).
  
  
  METHODS
  Sixty-one obese children/adolescents and 33 healthy children were included in the study. The obese group was divided into four subgroups, including MS (n=25), non-MS (n=36), liver steatosis (n=19) and non-liver steatosis (n=42) groups. Blood was collected to analyze biochemical parameters and IMA. Epicardial adipose tissue thickness was measured with echocardiography, and liver steotosis was determined with ultrasonography for each subject.
  
  
  RESULTS
  Body mass index (BMI), waist circumferences (WC), left ventricular mass (LVM) and epicardial adipose tissue (EAT) thickness were significantly higher in obese subjects. Serum IMA levels were significantly higher in the metabolic syndrome (MS) and hepatosteotosis groups. Additionally, LVM and EAT thickness were found to be correlated with serum IMA levels in these groups.
  
  
  CONCLUSIONS
  Our study suggests that serum IMA levels may be used to predict cardiovascular risk in obese children with MS and hepatosteotosis. This may be related to the duration of obesity in childhood ending in adulthood.
authors: Department of Pediatric Cardiology, Necmettin Erbakan University, Konya, Turkey.
authors: Tamer
authors: T
authors: Baysal
authors: Hayrullah
authors: H
authors: Alp
authors: Nesibe
authors: N
authors: Koç
authors: Mehmet Emre
authors: ME
authors: Atabek
authors: Beray Selver
authors: BS
authors: Eklioğlu
authors: Sevim
authors: S
authors: Karaarslan
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human