title: Acral myxoinflammatory fibroblastic sarcoma: cytopathologic findings on fine-needle aspiration.
abstract: BACKGROUND
  Acral myxoinflammatory fibroblastic sarcoma (AMFS) is a rare low-grade sarcoma with somewhat unique morphologic characteristics. While recurrences are relatively common, distant metastases are infrequent. Cytopathologic descriptions of AMFS are limited, prompting the current study.
  
  
  METHODS
  A retrospective review was performed at two tertiary-care hospitals, and 3 patients with this diagnosis were identified. The cytopathologic and clinical features were reviewed. The following clinical data was collected for each case: age, gender, site of lesion, treatment, and follow-up information.
  
  
  RESULTS
  Pertinent cytologic features included large atypical epithelioid cells with occasional macronucleoli and lipoblast-like features in a background of bland spindle cells, myxoid stroma, and inflammation. All patients presented with acral mass lesions. Metastatic disease to an inguinal lymph node was found in 1 patient.
  
  
  CONCLUSIONS
  AMFS is a low-grade sarcoma which shows some characteristic cytologic features. However, due to the presence of occasional bizarre and pleomorphic giant cells, there can be overlap with higher-grade sarcomas, and correlation with histology, immunohistochemistry, and imaging are required to make this diagnosis.
authors: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA.
authors: Adam D
authors: AD
authors: Toll
authors: Paul E
authors: PE
authors: Wakely
authors: Syed Z
authors: SZ
authors: Ali
mesh_terms: D000328:Adult; D000368:Aged; D015142:Baltimore; D044963:Biopsy, Fine-Needle; D015622:Epithelioid Cells / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000473:pathology*; D005528:Foot; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D009820:Ohio; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012509:Sarcoma / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000601:surgery; D017154:Stromal Cells / Q000473:pathology; D062606:Tertiary Care Centers