title: [Retrospective analysis concerning AFP-producing gastric cancer].
abstract: The α-fetoprotein(AFP)-producing gastric cancer is a group of gastric cancers with poor prognosis because of its rapid growth and aggressive metastatic character. We examined AFP-producing gastric cancer in our department from 2008 to 2010. Of 12 patients studied, the median of the AFP level was 16, 038(96. 1-167, 360)ng/mL. All patients had liver metastasis. Four patients were ECOG performance status(PS)3, and were unable to receive chemotherapy. Eight patients received chemotherapy. Two cases who received cisplatin+paclitaxel(CDDP+PTX)therapy showed partial response(PR). Median survival time was 5. 6 months. Compared to AFP non-producing gastric cancer, this disease is definitely considered to have a poorer prognosis. The clinical effect and survival time seemed to have a relative correlation. PR and SD groups tend to have longer survival. Those with a decline of serum LDH levels at the first three weeks after chemotherapy have a strong tendency to be PR and SD(p=0. 11). Changing the serum LDH level may enable us to estimate the clinical effect while still in the early stages of chemotherapy.
authors: Dept. of Clinical Oncology, Iwate Prefectural Central Hospital.
authors: Koji
authors: K
authors: Fukuda
authors: Shukuei
authors: S
authors: Ito
authors: Kenji
authors: K
authors: Shimizu
authors: Emiko
authors: E
authors: Mikami
authors: Shingo
authors: S
authors: Sakuraba
authors: Takeharu
authors: T
authors: Shiroki
authors: Atsushi
authors: A
authors: Ikehata
authors: Akihiko
authors: A
authors: Murakami
authors: Sadahide
authors: S
authors: Ono
authors: Tsutomu
authors: T
authors: Sakuma
authors: Satoshi
authors: S
authors: Kato
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D000509:alpha-Fetoproteins / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D000509:alpha-Fetoproteins