title: Light uncages a copper complex to induce nonapoptotic cell death.
abstract: Cu3G is a Cu(II) complex of a photoactive tetradentate ligand that is cleaved upon UV irradiation to release Cu. Here we show that the cytotoxicity of Cu3G increases in response to brief UV stimulation to result in extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.
authors: Duke University, Dept. of Chemistry, 124 Science Dr, Durham, NC 22708, USA.
authors: Anupa A
authors: AA
authors: Kumbhar
authors: Andrew T
authors: AT
authors: Franks
authors: Raymond J
authors: RJ
authors: Butcher
authors: Katherine J
authors: KJ
authors: Franz
mesh_terms: D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008024:Ligands; D061986:MCF-7 Cells; D008968:Molecular Conformation; D014466:Ultraviolet Rays
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D003300:Copper; D006861:Hydrogen Peroxide