title: Health-related quality of life, depression, and metabolic parameters in overweight insulin-resistant adolescents.
abstract: BACKGROUND
  The purpose of this study was to examine the incidence and severity of depression and health-related quality of life (HRQoL) in youth with insulin resistance (IR) who are overweight/obese and to examine the impact on making lifestyle changes.
  
  
  METHODS
  New patients presenting for treatment in an IR clinic were screened for depression and HRQoL and reassessed twice during a 1-year treatment period. Metabolic and growth parameters were obtained for each participant.
  
  
  RESULTS
  Elevated symptoms of depression were reported in 51% of the sample, and these symptoms were stable over time. Approximately 10% of these youth reported moderate or severe symptoms of depression. HRQoL scores indicated a good quality of life overall with slight improvement in some areas over time. Depression scores were not associated with demographic variables or metabolic parameters.
  
  
  CONCLUSIONS
  More than 50% of adolescents with IR and obesity reported elevated symptoms of depression. These results provide sufficient evidence for the need to conduct routine screening of depression for all youth with IR so that appropriate mental health referrals can be made.
authors: Section of Endocrinology, The Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA. amplatt@cmh.edu
authors: Adrienne M
authors: AM
authors: Platt
authors: Anna M
authors: AM
authors: Egan
authors: Mary Jane
authors: MJ
authors: Berquist
authors: Meredith L
authors: ML
authors: Dreyer
authors: Ghufran
authors: G
authors: Babar
authors: Figen
authors: F
authors: Ugrasbul
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D002648:Child; D003863:Depression / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006304:Health Status; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D008297:Male; D015146:Midwestern United States / Q000453:epidemiology; D050177:Overweight / Q000453:epidemiology / Q000517:prevention & control* / Q000523:psychology; D010349:Patient Compliance / Q000523:psychology / Q000706:statistics & numerical data*; D010353:Patient Education as Topic / Q000458:organization & administration*; D011788:Quality of Life; D040242:Risk Reduction Behavior; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires