title: Mechanotransduction: vinculin provides stability when tension rises.
abstract: By beautiful imaging and state-of-the-art experiments, vinculin is established to be a central switch in mechanotransduction at integrin-based focal adhesions. Cycles of tension-regulated vinculin switching control focal adhesion dynamics and signaling to enable polarized cell migration and alignment.
authors: The Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands. e.spanjaard@hubrecht.eu
authors: Emma
authors: E
authors: Spanjaard
authors: Johan
authors: J
authors: de Rooij
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D022001:Focal Adhesions / Q000378:metabolism*; D016596:Vinculin / Q000378:metabolism*
chemical_list: D016596:Vinculin