title: Bioinspired patterning with extreme wettability contrast on TiO2 nanotube array surface: a versatile platform for biomedical applications.
abstract: Binary wettability patterned surfaces with extremely high wetting contrasts can be found in nature on living creatures. They offer a versatile platform for microfluidic management. In this work, a facile approach to fabricating erasable and rewritable surface patterns with extreme wettability contrasts (superhydrophilic/superhydrophobic) on a TiO2 nanotube array (TNA) surface through self-assembly and photocatalytic lithography is reported. The multifunctional micropatterned superhydrophobic TNA surface can act as a 2D scaffold for site-selective cell immobilization and reversible protein absorption. Most importantly, such a high-contrast wettability template can be used to construct various well-defined 3D functional patterns, such as calcium phosphate, silver nanoparticles, drugs, and biomolecules in a highly selective manner. The 3D functional patterns would be a versatile platform in a wide range of applications, especially for biomedical devices (e.g., high-throughput molecular sensing, targeted antibacterials, and drug delivery). In a proof-of-concept study, the surface-enhanced Raman scattering and antibacterial performance of the fabricated 3D AgNP@TNA pattern, and the targeted drug delivery for site-specific and high-sensitivity cancer cell assays was investigated.
authors: Physikalisches Institute and Center for Nanotechnology (CeNTech), Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany; National Engineering Laboratory of Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, PR China. yklai80@gmail.com.
authors: Yuekun
authors: Y
authors: Lai
authors: Longxiang
authors: L
authors: Lin
authors: Fei
authors: F
authors: Pan
authors: Jianying
authors: J
authors: Huang
authors: Ran
authors: R
authors: Song
authors: Yongxia
authors: Y
authors: Huang
authors: Changjian
authors: C
authors: Lin
authors: Harald
authors: H
authors: Fuchs
authors: Lifeng
authors: L
authors: Chi
mesh_terms: D036103:Nanotechnology; D043942:Nanotubes / Q000737:chemistry*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D017155:Wettability
chemical_list: C009495:titanium dioxide; D014025:Titanium
keywords: TiO2 nanotubes; cell immobilization; micropatterns; silver nanoparticles; superhydrophilic-superhydrophobic