title: Value of autofluorescence in video-assisted thoracoscopic surgery in pleural diseases.
abstract: BACKGROUND
  Autofluorescence (AF) examination in thoracoscopy has not been used frequently. Here, our aim was to determine whether AF examination contributes additional information to white-light (WL) examination when attempting to detect malignant pleural lesions. We also liked to know whether the effectiveness of WL and AF-mode combination would be different for various pathologies or lesions of the pleura.
  
  
  METHODS
  It is a retrospective study. Thirty-three patients with unexplained exudative pleural effusions underwent AF-assisted video-assisted thoracic surgery (VATS). Patients' data from the files were evaluated. In each case, the pleural cavity was thoroughly examined under WL alone and then in AF mode.
  
  
  RESULTS
  The sensitivity and specificity of AF-assisted VATS for detecting malignant pleural lesions were 78.7 and 85%, respectively, and there were 21.3% false negatives. In the group with metastatic pleural disease, AF VATS correctly identified all lesions as AF positive, whereas sensitivity was lower for the group with malignant mesothelioma. Seven lesions, which were not diagnosed under WL, were detected in AF mode.
  
  
  CONCLUSIONS
  The overall sensitivity of AF-assisted VATS for detecting pleural malignancies was not satisfactory because of diagnostic errors in malignant mesothelioma. But it would be useful in detecting small malignant pleural lesions, which are not diagnosed under WL.
authors: Department of Thoracic Surgery, Kocaeli University, The Faculty of Medicine, Kocaeli, Turkey. tubaliman@kocaeli.edu.tr
authors: Serife Tuba
authors: ST
authors: Liman
authors: Aykut
authors: A
authors: Elicora
authors: Salih
authors: S
authors: Topcu
authors: Asli Gul
authors: AG
authors: Akgul
authors: Seymur Salih
authors: SS
authors: Mehmetoglu
authors: Ahmet
authors: A
authors: Ilgazli
authors: Cengiz
authors: C
authors: Ercin
authors: Nilay
authors: N
authors: Etiler
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061848:Optical Imaging; D010996:Pleural Effusion / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery*; D016066:Pleural Effusion, Malignant / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D010997:Pleural Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D020775:Thoracic Surgery, Video-Assisted; D055815:Young Adult