title: [Compound Xuanju Capsule combined with vitamin E improves sperm chromatin integrity].
abstract: OBJECTIVE
  To investigate the clinical effects of the combined therapy of the Chinese medicine Compound Xuanju Capsule and vitamin E on sperm chromatin damage in idiopathic oligoasthenospermia.
  
  
  METHODS
  We assigned 50 infertile men with seminal abnormality to a control group (n = 26) and a trial group (n = 24) to receive vitamin E and the combined therapy of Compound Xuanju Capsule plus vitamin E, respectively, both treated for 3 months. Before and after the treatment, we detected semen routine parameters and sperm DNA fragmentation indexes (DFI) by computer aided semen analysis (CASA) and sperm chromatin structure assay (SCSA), and compared them between the two groups.
  
  
  RESULTS
  There was no obvious difference between the percentage of progressively motile sperm in the trial group and that in the control group (21.55 +/- 8.68 vs 21.47 +/- 11.53, P > 0.05). The trial group showed a significantly decreased sperm DFI after medication as compared with pre-medication (29.57 +/- 12.19 vs 34.09 +/- 10.32, P < 0.05).
  
  
  CONCLUSIONS
  The combined therapy of Compound Xuanju Capsule and vitamin E can effectively improve seminal quality and reduce sperm chromatin damage in infertile men with idiopathic oligoasthenospermia.
authors: Institute of Reproductive Genetics/Research Institute of Reproductive Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
authors: Bing
authors: B
authors: Song
authors: Xiao-Jin
authors: XJ
authors: He
authors: Huan-Huan
authors: HH
authors: Jiang
authors: Yu-Wan
authors: YW
authors: Peng
authors: Huan
authors: H
authors: Wu
authors: Yun-Xia
authors: YX
authors: Cao
mesh_terms: D000328:Adult; D002214:Capsules; D002843:Chromatin / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D053938:DNA Fragmentation; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D013094:Spermatozoa / Q000187:drug effects*; D014810:Vitamin E / Q000494:pharmacology* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D002214:Capsules; D002843:Chromatin; D004365:Drugs, Chinese Herbal; D014810:Vitamin E