title: The protective role of maternally derived antibodies against Bordetella pertussis in young infants.
abstract: In 20 infants with polymerase chain reaction-confirmed pertussis <6 months of age, median cord blood anti-pertussis toxin, anti-filamentous hemagglutinin and anti-pertactin IgG antibody values were lower than in 80 matched controls: 10.5 versus 13.5 anti-pertussis toxin IU/mL, 14.5/18.0 (anti-filamentous hemagglutinin) and 6.0/9.0 (anti-pertactin), respectively. Although differences of median (and mean) antibody values between groups were not significant, they are in line with the concept of infant protection by maternal antibodies and thus support the strategy of pertussis booster immunization in pregnant women.
authors: Division of Pediatric Infectious Diseases, University Children's Hospital, University of Basel, Basel, Switzerland. Ulrich.Heininger@ukbb.ch
authors: Ulrich
authors: U
authors: Heininger
authors: Marion
authors: M
authors: Riffelmann
authors: Gurli
authors: G
authors: Bär
authors: Christoph
authors: C
authors: Rudin
authors: Carl-Heinz Wirsing
authors: CH
authors: von König
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D000992:Antitoxins / Q000097:blood; D001886:Bordetella pertussis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D000992:Antitoxins; D007074:Immunoglobulin G