title: Cytogenetic abnormalities in follicular dendritic cell sarcoma: report of two cases and literature review.
abstract: BACKGROUND
  The identification of chromosomal abnormalities in many hematopoietic and mesenchymal neoplasms has contributed significantly to classification systems. Follicular dendritic cell (FDC) sarcoma is an intermediate-grade malignancy with morphological and immunophenotypic features of follicular dendritic cells. Available data on genetic changes in this neoplasm are limited, with only isolated case reports of cytogenetic abnormalities.
  
  
  METHODS
  We reviewed histological, immunophenotypic and cytogenetic findings in two cases of FDC sarcoma. The two cases of FDC sarcoma, were observed in female patients, one was nodal and one extranodal and they exhibited relatively complex karyotypes, characterized by structural abnormalities and loss of multiple chromosomes. One patient had several disease recurrences. At the last follow-up both patients were alive with no residual disease.
  
  
  CONCLUSIONS
  The cytogenetic findings in these two cases, coupled with the few previously described abnormal karyotypes, suggest that FDC sarcoma is cytogenetically diverse.
authors: Department of Pathology, University of Manitoba, Health Sciences Centre, Winnipeg, MB, Canada.
authors: Anamarija M
authors: AM
authors: Perry
authors: Marilu
authors: M
authors: Nelson
authors: Warren G
authors: WG
authors: Sanger
authors: Julia A
authors: JA
authors: Bridge
authors: Timothy C
authors: TC
authors: Greiner
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002869:Chromosome Aberrations; D003131:Combined Modality Therapy; D054740:Dendritic Cell Sarcoma, Follicular / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D020566:Dendritic Cells, Follicular / Q000378:metabolism / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011612:Psychosurgery; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor