title: Of mice and men: fuzzy tandem repeats and divergent p53 transcriptional repertoires.
abstract: The clinical importance of tumor suppressor p53 makes it one of the most studied transcription factors. A comparison of mammalian p53 transcriptional repertoires may help identify fundamental principles in genome evolution and better understand cancer processes. Here we summarize mechanisms underlying the divergence of mammalian p53 transcriptional repertoires, with an emphasis on the rapid evolution of fuzzy tandem repeats containing p53 response elements.
authors: Institut Curie, Centre de Recherche, Paris, France.
authors: Aurélie
authors: A
authors: Morin
authors: Boris
authors: B
authors: Bardot
authors: Iva
authors: I
authors: Simeonova
authors: Vincent
authors: V
authors: Lejour
authors: Rachida
authors: R
authors: Bouarich-Bourimi
authors: Franck
authors: F
authors: Toledo
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D051379:Mice; D059372:Nucleotide Motifs; D011401:Promoter Regions, Genetic; D020218:Response Elements; D050717:Retinoblastoma-Like Protein p130 / Q000378:metabolism; D020080:Tandem Repeat Sequences; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D050717:Retinoblastoma-Like Protein p130; D016159:Tumor Suppressor Protein p53
keywords: fuzzy tandem repeat; genome evolution; p53; response element; retinoblastoma; transcriptional repertoires