title: The clinical significance of CA-125 in pulmonary tuberculosis.
abstract: Cancer antigen 125 (CA-125) is usually elevated in ovarian cancer. However, there are several reports that serum CA-125 is elevated in tuberculosis. This study investigated the clinical significance of serum CA-125 measurements in patients with active pulmonary tuberculosis (TB). Between September 2008 and March 2011, Serum CA-125 was measured in patients with active pulmonary TB before treatment (baseline), and 6 and 12 months after initiation of anti-TB treatment. Patients with pulmonary TB confirmed by culture or polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) were included. The study enrolled 100 patients. The mean serum CA-125 was 38.9 ± 41.4 U/ml (reference value, <35 U/ml). Thirty-eight patients showed elevated CA-125. Significantly more of those with elevated CA-125 were female (p < 0.001), and had a positive sputum smear for acid-fast bacilli (AFB) (p = 0.030). They also significantly more showed extensive pulmonary lesions on chest X-ray (p = 0.004). Elevated CA-125 was independently associated with female gender (OR = 12.5, 95% CI: 3.4-45.2), positive acid-fast staining of sputum (OR = 6.0, 95% CI: 1.8-19.7), cavitary lung lesion (OR = 4.0, 95% CI: 1.2-12.9), and involvement of more than one lung on chest X-ray (OR = 9.4, 95% CI: 2.2-40.1). The CA-125 level decreased with anti-TB treatment (p = 0.001). Serum CA-125 was related to the activity and severity of pulmonary TB, and it may be useful in the monitoring of therapeutic responses in certain cases of active pulmonary TB, especially in female patients of active pulmonary TB.
authors: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166, Gumi-Ro, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-707, Republic of Korea. apolio3700@gmail.com
authors: Eun Sun
authors: ES
authors: Kim
authors: Kyoung Un
authors: KU
authors: Park
authors: JungHan
authors: J
authors: Song
authors: Hyo-Jeong
authors: HJ
authors: Lim
authors: Young-Jae
authors: YJ
authors: Cho
authors: Hoil
authors: H
authors: Yoon
authors: JaeHo
authors: J
authors: Lee
authors: Choon-Taek
authors: CT
authors: Lee
authors: Jong Sun
authors: JS
authors: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D011446:Prospective Studies; D011859:Radiography; D012737:Sex Factors; D013183:Sputum / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D015415:Biomarkers; D018394:CA-125 Antigen