title: Very late isolated CNS relapse of acute myeloid leukemia.
abstract: Isolated central nervous system (CNS) relapse in acute myeloid leukemia (AML) rarely occurs later than 2 years after remission. We present a child diagnosed with AML (FAB M5) without CNS involvement at diagnosis who was treated with chemotherapy and consolidated with autologous hematopoietic stem cell transplantation. He was in complete remission for >6 years until he had an isolated CNS relapse. He was treated with only intrathecal chemotherapy and achieved a second complete remission, but relapsed in the bone marrow 5 months after the CNS relapse. Treatment of late isolated CNS relapse of AML is discussed.
authors: Pediatric Hematology Oncology Department, Hospital Niño Jesús, Madrid, Spain.
authors: Blanca
authors: B
authors: Molina
authors: Alvaro
authors: A
authors: Lassaletta
authors: Marta
authors: M
authors: Gonzalez-Vicent
authors: Maitane
authors: M
authors: Andión
authors: Miguel A
authors: MA
authors: Diaz
authors: Luis
authors: L
authors: Madero
mesh_terms: D019002:CD56 Antigen / Q000032:analysis; D016543:Central Nervous System Neoplasms / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D012008:Recurrence; D013997:Time Factors; D014182:Transplantation, Autologous
chemical_list: D019002:CD56 Antigen; C522918:NCAM1 protein, human