title: Alcohol abuse and the injured host:  dysregulation of counterregulatory mechanisms review.
abstract: Traumatic injury ranks as the number one cause of death for the younger than 44 years age group and fifth leading cause of death overall (www.nationaltraumainstitute.org/home/trauma_statistics.html). Although improved resuscitation of trauma patients has dramatically reduced immediate mortality from hemorrhagic shock, long-term morbidity and mortality continue to be unacceptably high during the postresuscitation period particularly as a result of impaired host immune responses to subsequent challenges such as surgery or infection. Acute alcohol intoxication (AAI) is a significant risk factor for traumatic injury, with intoxicating blood alcohol levels present in more than 40% of injured patients. Severity of trauma, hemorrhagic shock, and injury is higher in intoxicated individuals than that of sober victims, resulting in higher mortality rates in this patient population. Necessary invasive procedures (surgery, anesthesia) and subsequent challenges (infection) that intoxicated trauma victims are frequently subjected to are additional stresses to an already compromised inflammatory and neuroendocrine milieu and further contribute to their morbidity and mortality. Thus, dissecting the dynamic imbalance produced by AAI during trauma is of critical relevance for a significant proportion of injured victims. This review outlines how AAI at the time of hemorrhagic shock not only prevents adequate responses to fluid resuscitation but also impairs the ability of the host to overcome a secondary infection. Moreover, it discusses the neuroendocrine mechanisms underlying alcohol-induced hemodynamic dysregulation and its relevance to host defense restoration of homeostasis after injury.
authors: Department of Physiology and Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, USA. pmolin@lsuhsc.edu
authors: Patricia E
authors: PE
authors: Molina
authors: Jesse K
authors: JK
authors: Sulzer
authors: Annie M
authors: AM
authors: Whitaker
mesh_terms: D000437:Alcoholism / Q000150:complications* / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology; D000431:Ethanol / Q000506:poisoning; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D009481:Neurophysins / Q000502:physiology; D009490:Neurosecretory Systems / Q000503:physiopathology; D011498:Protein Precursors / Q000502:physiology; D012151:Resuscitation / Q000379:methods; D012771:Shock, Hemorrhagic / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D014667:Vasopressins / Q000502:physiology; D014947:Wounds and Injuries / Q000209:etiology* / Q000503:physiopathology
chemical_list: C438657:AVP protein, human; D009481:Neurophysins; D011498:Protein Precursors; D014667:Vasopressins; D000431:Ethanol