title: A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma.
abstract: OBJECTIVE
  This Phase I study assessed the feasibility of concomitant arsenic trioxide (ATO), ascorbic acid (AA), and bortezomib (Velcade™) (AAV) for patients with relapsed/refractory multiple myeloma.
  
  
  METHODS
  ATO (0.25 mg/kg) and AA (1 g) were given with an escalating dose of bortezomib (1 mg/m(2) or 1.3 mg/m(2) IV bolus on days 1 and 8 of a 21-day cycle).
  
  
  RESULTS
  Ten patients (median age 62 years), with a median of 3 prior regimens, were enrolled. Four (40%) patients achieved clinical benefit, with one patient achieving a durable partial response. No formal DLTs were encountered.
  
  
  CONCLUSIONS
  AAV combination was feasible and demonstrated some benefits in this heavily pretreated population.
authors: Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors: Lauren A
authors: LA
authors: Held
authors: David
authors: D
authors: Rizzieri
authors: Gwynn D
authors: GD
authors: Long
authors: Jon P
authors: JP
authors: Gockerman
authors: Louis F
authors: LF
authors: Diehl
authors: Carlos M
authors: CM
authors: de Castro
authors: Joseph O
authors: JO
authors: Moore
authors: Mitchell E
authors: ME
authors: Horwitz
authors: Nelson J
authors: NJ
authors: Chao
authors: Cristina
authors: C
authors: Gasparetto
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000008:administration & dosage; D001205:Ascorbic Acid / Q000008:administration & dosage; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D010087:Oxides / Q000008:administration & dosage; D011719:Pyrazines / Q000008:administration & dosage; D012008:Recurrence
chemical_list: D001152:Arsenicals; D001897:Boronic Acids; D010087:Oxides; D011719:Pyrazines; D000069286:Bortezomib; D001205:Ascorbic Acid; D000077237:Arsenic Trioxide