title: Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: a systematic review.
abstract: OBJECTIVE
  The use of oral anticancer drugs has increased in modern oncology treatment. The move from intravenous treatments towards oral anticancer drugs has increased the patients' own responsibility to take oral anticancer drugs as being prescribed. High rates of non-adherence to oral anticancer drugs have been reported. A systematic literature review was conducted to gain insight into determinants and associated factors of non-adherence and non-persistence in patients taking oral anticancer therapy.
  
  
  METHODS
  PubMed, Cochrane, Web of Science and Cinahl were systematically searched for studies focusing on determinants and associated factors of medication non-adherence and non-persistence to oral anticancer drugs. The methodological quality of the included studies was assessed by two independent reviewers. No studies were excluded based on the quality assessment.
  
  
  RESULTS
  Twenty-five studies were included and systematically reviewed. The quality of the studies was moderate. Associated factors influencing medication non-adherence and non-persistence to oral anticancer drugs are multifactorial and interrelated. Older and younger age, and the influence of therapy related side effects were found to be predominant factors.
  
  
  CONCLUSIONS
  Non-adherence and non-persistence to oral anticancer drug therapy are complex phenomena. More qualitative research is needed to facilitate the development of patient tailored complex interventions by exploring patients' needs and underlying processes influencing medication non-adherence and non-persistence to oral anticancer drugs.
authors: Nursing Science, Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. Mathieu.Verbrugghe@UGent.be
authors: M
authors: M
authors: Verbrugghe
authors: S
authors: S
authors: Verhaeghe
authors: K
authors: K
authors: Lauwaert
authors: D
authors: D
authors: Beeckman
authors: A
authors: A
authors: Van Hecke
mesh_terms: D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006801:Humans; D055118:Medication Adherence; D009369:Neoplasms / Q000188:drug therapy* / Q000523:psychology*
chemical_list: D000970:Antineoplastic Agents