title: Frequency of the E23K polymorphism of the KCNJ11 gene in children born small for gestational age and its influence on auxological and metabolic parameters in the prepubertal period.
abstract: BACKGROUND
  The E23K variant of the KCNJ11 gene is possibly responsible for changes in insulin secretion during the fetal life. We tried to assess the influence of the E23K variant on birth weight and metabolic profile in prepubertal children born small for gestational age (SGA).
  
  
  METHODS
  One hundred and twenty-three SGA and 132 born appropriate for gestational age (AGA) children were genotyped for the E23K variant. Lipids, glucose, and insulin concentrations during oral glucose tolerance test were assessed in 112 SGA prepubertal children.
  
  
  RESULTS
  There were no significant differences between the frequency of the E23K variant in SGA and AGA children. In SGA children with E23K, the mean birth weight was significantly higher than in the E23E group. Body mass index, glucose, insulin, and lipids were not different between the E23K, E23E, and K23K groups.
  
  
  CONCLUSIONS
  The higher birth weight in SGA children with the E23K variant may be related to higher insulin concentrations in the fetal period. The E23K variant did not affect metabolic disorders in prepubertal SGA children.
authors: Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
authors: Renata
authors: R
authors: Stawerska
authors: Małgorzata
authors: M
authors: Szałapska
authors: Maciej
authors: M
authors: Borowiec
authors: Wojciech
authors: W
authors: Młynarski
authors: Karolina
authors: K
authors: Antosik
authors: Maciej
authors: M
authors: Hilczer
authors: Andrzej
authors: A
authors: Lewiński
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D004734:Energy Metabolism / Q000235:genetics*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D000099161:Kcnj11 Channel
chemical_list: D001786:Blood Glucose; D007328:Insulin; D024661:Potassium Channels, Inwardly Rectifying; D000099161:Kcnj11 Channel