title: Syndrome of inadequate antidiuretic hormone secretion in pulmonary tuberculosis - a therapeutic challenge.
abstract: A forty-nine-year-old female patient with pulmonary tuberculosis developed syndrome of inadequate antidiuretic hormone secretion. Consequent restriction of fluid intake as a therapeutic measure was just as ineffective as a medication with tolvaptan which was performed later on. A probable explanation for the inefficacy of the aquaretic drug is an interaction of rifampicine and tolvaptan. This case report gives a short summary of SIADH in pulmonary TB and discusses possible reasons for the difficult antituberculotic treatment in this patient.
authors: Department of Internal Medicine III - Respiratory and Critical Care Medicine, Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil GmbH, Ruhr-University of Bochum, Germany. Heiko.Knoop@ruhr-unibochum.de
authors: H
authors: H
authors: Knoop
authors: U
authors: U
authors: Knoop
authors: J
authors: J
authors: Behr
authors: C M
authors: CM
authors: Heyer
authors: S
authors: S
authors: Kuert
authors: D
authors: D
authors: Roggenland
authors: M
authors: M
authors: Suermann
authors: J W
authors: JW
authors: Dietrich
mesh_terms: D000904:Antibiotics, Antitubercular / Q000008:administration & dosage; D001552:Benzazepines / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004039:Diet, Sodium-Restricted; D004347:Drug Interactions; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000628:therapy*; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage*; D013577:Syndrome; D000077602:Tolvaptan; D017211:Treatment Failure; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000904:Antibiotics, Antitubercular; D001552:Benzazepines; D000077602:Tolvaptan; D012293:Rifampin