title: The blue-light receptor YtvA from Bacillus subtilis is permanently incorporated into the stressosome independent of the illumination state.
abstract: Higher organisms as well as bacteria rely on information on the surrounding environment. In Bacillus subtilis, diverse extra-cellular stimuli are transformed into an intra-cellular response via a signal integration hub, called the stressosome. The subsequent signal transduction cascade initiates the general stress response (GSR). One of these stimuli is blue light, which is sensed by the bacterial photoreceptor YtvA. We report here that YtvA is permanently incorporated into the stressosome independent of its illumination state and that RsbT stimulation occurs without direct interaction between the kinase RsbT and YtvA but in a light dependent manner. Furthermore, we show that RsbRA adopts a scaffolding function inside the stressosome explaining on a molecular level why RsbRA is required for light-mediated stress response in vivo.
authors: Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
authors: Marcel
authors: M
authors: Jurk
authors: Philipp
authors: P
authors: Schramm
authors: Peter
authors: P
authors: Schmieder
mesh_terms: D001412:Bacillus subtilis / Q000378:metabolism* / Q000528:radiation effects*; D001426:Bacterial Proteins / Q000378:metabolism*; D008027:Light; D010750:Phosphoproteins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D013312:Stress, Physiological
chemical_list: D001426:Bacterial Proteins; D010750:Phosphoproteins; C119218:RsbR protein, Bacillus subtilis; C119219:RsbT protein, Bacillus subtilis; D017346:Protein Serine-Threonine Kinases