title: Transient isolated marked elevation of midregion parathyroid hormone fragments in an infant.
abstract: We describe here a Japanese male infant who transiently showed a marked elevation of midregion parathyroid hormone (M-PTH) fragments in serum with no increase in full-length 1-84 amino acid PTH and carboxy-terminal PTH fragments. He presented with a large anterior fontanel, delayed closure of the anterior fontanel, and mild short stature at 4 months old; he was normocalcemic with a normal urine calcium/creatinine ratio and absent subperiosteal bone resorption on X-ray film. Serum levels of M-PTH fragments were in >3200 pg/mL but logarithmically decreased with age. Our case report demonstrates that M-PTH fragments have no effect on calcium release from bones in humans.
authors: Department of Pediatrics, University of Yamanashi, Yamanashi, Japan. tnakane99@gmail.com
authors: Takaya
authors: T
authors: Nakane
authors: Kohsuke
authors: K
authors: Higashida
authors: Kanji
authors: K
authors: Sugita
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*
chemical_list: D010281:Parathyroid Hormone; D010446:Peptide Fragments