title: Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx.
abstract: Interleukin-10 (IL-10) plays an important role in a host's defense against human papillomavirus (HPV) infection. IL-10 promoter variants may affect its expression level or functional efficiency and, subsequently, susceptibility to and survival of HPV16-associated squamous cell carcinoma of oropharynx (SCCOP). We determined tumor HPV16 DNA and genotyped three IL-10 promoter polymorphisms in 309 incident patients with SCCOP. Compared with the patients with corresponding common homozygous genotypes, patients carrying variant genotypes of IL-10 rs1800871 and rs1800872 were ~2.5 times more likely to have HPV16(+) tumors among patients with SCCOP. Among HPV16(+) patients with SCCOP only, compared to those with the corresponding variant genotypes, the patients with IL-10 rs1800871 and rs1800872 CC genotypes had significantly better survival and ~70-80% reduced risk of death/recurrence after multivariable adjustment. Additionally, functional relevance of these variants was characterized to explore the genotype-phenotype correlation. Our findings indicate that IL-10 genetic variants may be associated with tumor HPV16(+) SCCOP and predict survival of HPV16(+) patients with SCCOP. Larger studies are needed to validate our findings.
authors: Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
authors: Lei
authors: L
authors: Jin
authors: Erich M
authors: EM
authors: Sturgis
authors: Xiaolin
authors: X
authors: Cao
authors: Xicheng
authors: X
authors: Song
authors: Taufiq
authors: T
authors: Salahuddin
authors: Qingyi
authors: Q
authors: Wei
authors: Guojun
authors: G
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D052162:Human papillomavirus 16 / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications / Q000235:genetics* / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D017741:Survivors
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: HPV; IL-10 variants; biomarkers; oropharyngeal cancer; smoking; survival