title: Preoperative serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen level predicts postoperative distant metastasis in patients with non-small-cell lung cancer.
abstract: OBJECTIVE
  To examine the relationship between preoperative serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (I-CTP) levels and postoperative distant metastasis in patients with non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  We retrospectively reviewed 143 patients in whom preoperative serum I-CTP level was measured from January 2006 to March 2011, including 91 males and 52 females with an average age of 70.1 ± 8.2 years. Histological subtypes included adenocarcinoma (n = 95), squamous cell carcinoma (n = 34) and other (n = 14). Preoperative serum carcinoembryonic antigen (CEA) and cytokeratin-19 fragment (CYFRA) levels were also measured. Patients with abnormal renal function or preoperative bone fractures were excluded.
  
  
  RESULTS
  The mean preoperative serum I-CTP level was 4.1 ± 1.6 ng/ml, and the preoperative serum I-CTP level was elevated (>4.5 ng/ml) in 29 patients. Distant metastasis was detected in 21 patients during the 39 ± 18 (range 1-79) months of follow-up. The rate of distant metastasis was significantly higher in patients with elevated preoperative serum I-CTP levels than those with normal preoperative I-CTP levels (≤4.5 ng/ml) (P < 0.0001). The 5-year recurrence-free survival rate was lower in patients with elevated preoperative serum I-CTP levels than those with normal preoperative I-CTP levels (41.8 vs 92.9%; P < 0.0001).
  
  
  CONCLUSIONS
  An elevated preoperative serum I-CTP level predicts postoperative distant metastasis in patients with NSCLC.
authors: Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, Wakayama, Japan. dingo_love524@yahoo.co.jp
authors: Yumi
authors: Y
authors: Tanaka
authors: Tatsuya
authors: T
authors: Yoshimasu
authors: Shoji
authors: S
authors: Oura
authors: Yoshimitsu
authors: Y
authors: Hirai
authors: Mitsumasa
authors: M
authors: Kawago
authors: Masako
authors: M
authors: Ikeda
authors: Yoshitaka
authors: Y
authors: Okamura
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000473:pathology*; D024042:Collagen Type I / Q000097:blood*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D053539:Keratin-19 / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology*; D008297:Male; D009362:Neoplasm Metastasis; D010455:Peptides / Q000097:blood*; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D024042:Collagen Type I; D053539:Keratin-19; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide
keywords: Non-small-cell lung cancer; Postoperative distant metastasis; Pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen