title: Incidence of cervical intraepithelial neoplasia in Estonia.
abstract: OBJECTIVE
  This study aimed to assess the incidence of cervical intraepithelial neoplasia (CIN) by grade (CIN 1, CIN 2, CIN 3) and age in Estonia (a country with less developed cervical cancer screening program and high cervical cancer incidence).
  
  
  METHODS
  This descriptive study uses data from a health insurance fund covering the whole country to estimate the incidence of CIN by grade. CIN case definition was based on specific diagnostic procedures (biopsy, pathological diagnosis, and colposcopy) and/or treatment procedures (excision, local destructive therapy, conization, and hysterectomy) with the CIN-specific diagnosis code (International Statistical Classification of Diseases, 10 Revision) reported on health care claims. Age-specific incidence rates were calculated together with the 95% CIs. Main outcome measure includes CIN grade-specific incidence rate per 1,000 women.
  
  
  RESULTS
  The estimates for CIN incidence per 1,000 women range from 0.68 to 2.83 for CIN 1, 0.63 to 1.24 for CIN 2, and 0.13 to 0.53 for CIN 3 for narrow (biopsy/pathological diagnosis based) and broad (any CIN-specific diagnostic procedure/treatment based) case definition criteria, respectively.
  
  
  CONCLUSIONS
  Our estimates for cervical dysplasia disease frequency and age distribution are in line with those from other developed countries. Administrative health care resources (such as health insurance fund data) are a valuable source for health research.
authors: Department of Public Health, University of Tartu, Tartu 50411, Estonia. anneli.uuskula@ut.ee
authors: Anneli
authors: A
authors: Uusküla
authors: Mait
authors: M
authors: Raag
authors: Arno
authors: A
authors: Uppin
authors: Terje
authors: T
authors: Raud
authors: Ursula
authors: U
authors: Klaar
authors: Mikk
authors: M
authors: Jürisson
authors: Andres
authors: A
authors: Müürsepp
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004957:Estonia / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D012720:Severity of Illness Index; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology*