title: Peptide-binding motifs associated with MHC molecules common in Chinese rhesus macaques are analogous to those of human HLA supertypes and include HLA-B27-like alleles.
abstract: Chinese rhesus macaques are of particular interest in simian immunodeficiency virus/human immunodeficiency virus (SIV/HIV) research as these animals have prolonged kinetics of disease progression to acquired immunodeficiency syndrome (AIDS), compared to their Indian counterparts, suggesting that they may be a better model for HIV. Nevertheless, the specific mechanism(s) accounting for these kinetics remains unclear. The study of major histocompatibility complex (MHC) molecules, including their MHC/peptide-binding motifs, provides valuable information for measuring cellular immune responses and deciphering outcomes of infection and vaccine efficacy. In this study, we have provided detailed characterization of six prevalent Chinese rhesus macaque MHC class I alleles, yielding a combined phenotypic frequency of 29 %. The peptide-binding specificity of two of these alleles, Mamu-A2*01:02 and Mamu-B*010:01, as well as the previously characterized allele Mamu-B*003:01 (and Indian rhesus Mamu-B*003:01), was found to be analogous to that of alleles in the HLA-B27 supertype family. Specific alleles in the HLA-B27 supertype family, including HLA-B*27:05, have been associated with long-term nonprogression to AIDS in humans. All six alleles characterized in the present study were found to have specificities analogous to HLA supertype alleles. These data contribute to the concept that Chinese rhesus macaque MHC immunogenetics is more similar to HLA than their Indian rhesus macaque counterparts and thereby warrants further studies to decipher the role of these alleles in the context of SIV infection.
authors: Department of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. bmothe@csusm.edu
authors: Bianca R
authors: BR
authors: Mothé
authors: Scott
authors: S
authors: Southwood
authors: John
authors: J
authors: Sidney
authors: A Michelle
authors: AM
authors: English
authors: Amanda
authors: A
authors: Wriston
authors: Ilka
authors: I
authors: Hoof
authors: Jeffrey
authors: J
authors: Shabanowitz
authors: Donald F
authors: DF
authors: Hunt
authors: Alessandro
authors: A
authors: Sette
mesh_terms: D000483:Alleles; D020816:Amino Acid Motifs; D000818:Animals; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D015796:HLA-B27 Antigen / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008253:Macaca mulatta; D010446:Peptide Fragments / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D019151:Peptide Library; D011485:Protein Binding; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D006680:HLA Antigens; D015796:HLA-B27 Antigen; D010446:Peptide Fragments; D019151:Peptide Library