title: Metabolic transitions at menopause: in post-menopausal women the increase in serum uric acid correlates with abdominal adiposity as assessed by DXA.
abstract: OBJECTIVE
  The present study aimed to investigate any associations between parameters of body fat mass distribution and levels of serum uric acid (sUA), a well-documented cardiovascular risk factor, among non-obese women ranging from pre- to post-menopausal status.
  
  
  METHODS
  In this cross-sectional population-based study we assessed body fat distribution by dual-energy-X-ray absorptiometry (DXA), and sUA levels in 101 pre- and 134 post-menopausal non-obese apparently healthy women.
  
  
  RESULTS
  Multivariate stepwise regression analysis revealed that sUA was independently associated to the indicators of overall fatness, i.e. body mass index (β=0.339, p<0.001) and DXA-assessed total and percentage body fat (β=0.366, p<0.001 and β=0.412, p<0.001, respectively), only among post-menopausal women. Within this sample subset, trunk (i.e. central) fat mass emerged as a strong predictor of sUA (β=0.408, p<0.001), after taking the potential confounders (including body mass index) into account.
  
  
  CONCLUSIONS
  Central fat accumulation was found to be independently associated with higher sUA levels among non-obese women in post- but not among those in pre-menopause.
authors: Department of Biochemistry and Molecular Biology, University of Ferrara, via Luigi Borsari 46, Ferrara, Italy.
authors: Eleonora
authors: E
authors: Cremonini
authors: Gloria
authors: G
authors: Bonaccorsi
authors: Carlo M
authors: CM
authors: Bergamini
authors: Cristina
authors: C
authors: Castaldini
authors: Stefania
authors: S
authors: Ferrazzini
authors: Alessandra
authors: A
authors: Capatti
authors: Leo
authors: L
authors: Massari
authors: Arianna
authors: A
authors: Romani
authors: Roberto
authors: R
authors: Marci
authors: Enrica
authors: E
authors: Fila
authors: Carlo
authors: C
authors: Ferrari
authors: Carlo
authors: C
authors: Cervellati
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D015502:Absorptiometry, Photon; D050154:Adiposity / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017698:Postmenopause / Q000097:blood*; D012044:Regression Analysis; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid