title: Large-scale and facile synthesis of biocompatible Yb-based nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging.
abstract: X-ray computed tomography (CT), an efficient non-invasive clinical technique, usually provides high-resolution 3D structure details of tissues in early disease diagnosis. Here, we report a high-performance CT imaging platform based on a monodispersed Yb-based nanoparticulate contrast agent. The well-prepared nanoprobes presented excellent in vitro and in vivo performances in the CT imaging, very low cytotoxicity and no detectable tissue damage in one month. More significantly, compared with routinely used Iobitridol in clinic, our Yb-based CT contrast agents provided much more enhanced contrast at a clinical 120 kVp voltage. Additionally, these nanoparticulate contrast agent could be excreted mainly via feces and urine, indicating the total elimination from the animal bodies and more potential for further biomedical applications.
authors: Department of Radiology, The Second Hospital of Jilin University, Changchun, P. R. China.
authors: Jianhua
authors: J
authors: Liu
authors: Rui
authors: R
authors: Xin
authors: Zhiman
authors: Z
authors: Li
authors: Reza
authors: R
authors: Golamaully
authors: Yan
authors: Y
authors: Zhang
authors: Jishen
authors: J
authors: Zhang
authors: Qinghai
authors: Q
authors: Yuan
authors: Xiaodong
authors: X
authors: Liu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D014057:Tomography, X-Ray Computed / Q000379:methods*; D015018:Ytterbium / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D015018:Ytterbium