title: [Preliminary study to evaluate the meaning of GGT fractions analysis in a population of workers previously exposed to asbestos].
abstract: The GGT enzyme, considered for years only as a marker of liver disease and alcohol abuse, has now revealed a risk of death for many causes. Through a molecular exclusion chromatography on FPLC system (Fast Protein Liquid Chromatography), it is possible to discriminate four fractions of GGT, defined according to the molecular weight: big-GGT, medium-GGT, small-GGT and free-GGT. The objective was to study the preventing meaning of GGT fractions for asbestos-related diseases. This study was conducted on 129 workers previously exposed to asbestos, 22 patients affected by Malignant Pleural Mesothelioma and 107 healthy workers. Our data demonstrated a statistical significant correlation between the fraction free-GGT with the presence of MPM, suggesting a possible role for this molecule as a biomarker for MPM diagnosis. However, being a preliminary study, further studies are warranted to confirm our results.
authors: Dipartimento di Endocrinologia e metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro - Università di Pisa, via Paradisa 2, Pisa. rudy.foddis@med.unipi.it
authors: R
authors: R
authors: Foddis
authors: A
authors: A
authors: Bonotti
authors: F
authors: F
authors: Sderci
authors: A
authors: A
authors: Pistelli
authors: E
authors: E
authors: Pantani
authors: M
authors: M
authors: Franzini
authors: A
authors: A
authors: Paolicchi
authors: A
authors: A
authors: Baggiani
authors: A
authors: A
authors: Cristaudo
mesh_terms: D001195:Asbestosis / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood*; D016273:Occupational Exposure / Q000009:adverse effects*; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human