title: Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration.
abstract: Traumatic injury or surgery may trigger extensive bleeding. However, conventional hemostatic methods have limited efficacy and may cause surrounding tissue damage. In this study, we use self-assembling peptides (SAPs) and specifically extend fragments of functional motifs derived from fibronectin and laminin to evaluate the capability of these functionalized SAPs in the effect of hemostasis and liver tissue regeneration. From the results, these peptides can self-assemble into nanofibrous network structure and gelate into hydrogel with pH adjustment. In animal studies, the efficacy of hemostasis is achieved immediately within seconds in a rat liver model. The histological analyses by hematoxylin-eosin stain and immunohistochemistry reveal that SAPs with these functionalized motifs significantly enhance liver tissue regeneration. In brief, these SAPs may have potential as pharmacological tools to extensively advance clinical therapeutic applications in hemostasis and tissue regeneration in the field of regenerative medicine.
authors: Department of Materials Science and Engineering, and Institute of Biomedical Engineering, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, Taiwan 30013, ROC.
authors: Tzu-Yun
authors: TY
authors: Cheng
authors: Hsi-Chin
authors: HC
authors: Wu
authors: Ming-Yuan
authors: MY
authors: Huang
authors: Wen-Han
authors: WH
authors: Chang
authors: Chao-Hsiung
authors: CH
authors: Lee
authors: Tzu-Wei
authors: TW
authors: Wang
mesh_terms: D000818:Animals; D006487:Hemostasis / Q000187:drug effects*; D006489:Hemostatic Techniques; D008115:Liver Regeneration / Q000187:drug effects*; D049329:Nanostructures; D010455:Peptides / Q000494:pharmacology*; D058105:Polymerization; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010455:Peptides