title: [Primitive neuroectodermal tumor/Ewing's sarcoma of the penis in children: a case report and review of the literature].
abstract: OBJECTIVE
  To investigate the clinical manifestations, pathological characteristics and treatment of primitive neuroectodermal tumor/Ewing's sarcoma (PNET/EWS) of the penis in children.
  
  
  METHODS
  We analyzed the clinical data of a case of PNET/EWS and reviewed relevant literature.
  
  
  RESULTS
  The patient was a 5-year-old boy, admitted for penis swelling with pain for 11 months. Biopsy showed a small round cell tumor, CD99 positive by immunohistochemical staining, with EWS translocation by fluorescence in situ hybridization on molecular biological examination. The tumor was confirmed to be PNET/EWS of the penis, and disappeared after 45 weeks of chemotherapy and local radiotherapy.
  
  
  CONCLUSIONS
  PNET/EWS of the penis is an extremely rare disease, with no specific clinical symptoms except penis enlargement with pain. Immunohistochemistry and molecular biological examination contribute to its diagnosis.
authors: Department of Hematology, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, Beijing 100045, China.
authors: Da-Wei
authors: DW
authors: Zhang
authors: Mei
authors: M
authors: Jin
authors: Chun-Ju
authors: CJ
authors: Zhou
authors: Hong-Cheng
authors: HC
authors: Song
authors: Xiao-Li
authors: XL
authors: Ma
mesh_terms: D002675:Child, Preschool; D006801:Humans; D008297:Male; D018241:Neuroectodermal Tumors, Primitive, Peripheral; D010412:Penile Neoplasms; D012512:Sarcoma, Ewing