title: pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols.
abstract: Benzo-fused cyclobutanols were developed as novel DNA cleaving molecules. The molecules nick a strand of supercoiled DNA under acidic conditions. By contrast, almost no activity was observed under neutral or basic conditions.
authors: Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Kyoto 505-8501, Japan.
authors: Yuuki
authors: Y
authors: Nagamoto
authors: Akira
authors: A
authors: Hattori
authors: Hideaki
authors: H
authors: Kakeya
authors: Yoshiji
authors: Y
authors: Takemoto
authors: Kiyosei
authors: K
authors: Takasu
mesh_terms: D003503:Cyclobutanes / Q000138:chemical synthesis / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010957:Plasmids / Q000737:chemistry*
chemical_list: D003503:Cyclobutanes; C538814:cyclobutanol; D004247:DNA