title: A rolling stone gathers no moss, but resistant plants must gather their moses.
abstract: The detection of pathogenic microbes by plant resistance (R) proteins and the subsequent activation of R protein-mediated immunity constitute an important layer in the plant innate immune system. Most R genes encode proteins with nucleotide-binding (NB) and leucine-rich repeat (LRR) domains. The autoimmune mutant suppressor of npr1, constitutive 1 (snc1), that constitutively activates resistance signaling, is a unique model used in our laboratory to dissect the details of TIR (Toll/Interleukin1 receptor)-NB-LRR, protein-mediated defense responses. Suppressor screens of snc1 yielded 15 modifier of snc1 (mos) complementation groups containing second-site mutations, and resulted in the identification of 13 novel MOS genes via either positional cloning or T-DNA tagging. Characterizations of the mos mutants have revealed important roles for transcriptional regulation, RNA processing, protein modifications, and nucleocytoplasmic trafficking in R protein-mediated immunity. The MOS genes have taught us a great deal about the complex mechanisms surrounding R protein activation. Future in-depth genetic and biochemical analyses will further enhance our knowledge of how R proteins are deliberately activated and how specific, targeted immunity is achieved in plants.
authors: Michael Smith Laboratories, University of British Columbia, Vancouver, British Colombia, Canada V6T 1Z4.
authors: K C M
authors: KC
authors: Johnson
authors: O X
authors: OX
authors: Dong
authors: Y
authors: Y
authors: Huang
authors: X
authors: X
authors: Li
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000235:genetics; D060467:Disease Resistance / Q000235:genetics / Q000276:immunology*; D018506:Gene Expression Regulation, Plant; D008954:Models, Biological; D010935:Plant Diseases / Q000235:genetics / Q000276:immunology*; D010940:Plant Proteins / Q000378:metabolism*
chemical_list: D010940:Plant Proteins