title: Serum non-high-density lipoprotein cholesterol levels and the incidence of ischemic stroke in a Japanese population: the Jichi Medical School cohort study.
abstract: The predictive value of serum non-high-density lipoprotein cholesterol (non-HDL-C) levels for the incidence of ischemic stroke and its subtypes has not yet been established. The present cohort study investigated their relationships in a Japanese population. The first incidence of ischemic stroke and its subtypes was documented as the primary outcome. A total of 249 ischemic stroke patients (men/women = 145/104) were identified during a follow-up period of 10.7 years among 10 760 community-dwelling subjects (men/women = 4212/6548). Cox proportional hazard model analyses revealed that when compared with the lowest tertile of non-HDL-C, multivariate-adjusted hazard ratios for the highest tertile were 0.55 (95% confidence interval = 0.32-0.95, P = .03) on ischemic stroke and 0.29 (95% confidence interval = 0.08-1.05, P = .06) on cardioembolic infarction in women. Men did not show such significant relationships. Low serum non-HDL-C levels may be a predictive marker associated with an increase in the incidence of ischemic stroke and possibly of cardioembolic infarction in Japanese women.
authors: Jichi Medical University, Tochigi, Japan.
authors: Eiichi
authors: E
authors: Kakehi
authors: Jichi Medical University, Tochigi, Japan.
authors: Kazuhiko
authors: K
authors: Kotani
authors: Jichi Medical University, Tochigi, Japan i-shizu@jichi.ac.jp.
authors: Shizukiyo
authors: S
authors: Ishikawa
authors: Wara National Health Insurance Clinic, Gifu, Japan.
authors: Tadao
authors: T
authors: Gotoh
authors: Saitama Prefectural University, Saitama, Japan.
authors: Kazunori
authors: K
authors: Kayaba
authors: Jichi Medical University, Tochigi, Japan.
authors: Yosikazu
authors: Y
authors: Nakamura
authors: Jichi Medical University, Tochigi, Japan.
authors: Eiji
authors: E
authors: Kajii
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002545:Brain Ischemia / Q000453:epidemiology*; D002784:Cholesterol / Q000097:blood* / Q000145:classification*; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012577:Schools, Medical; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D002784:Cholesterol
keywords: ischemic stroke; ischemic stroke subtypes; non-high-density lipoprotein cholesterol; population-based survey