title: Prevalence of Helicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in Kashmir, India.
abstract: OBJECTIVE
  Epidemiology of Helicobacter pylori infection has regional variation. Effect of eradication of H. pylori on symptoms of functional dyspepsia is uncertain, and the data in Asian scenario are scanty. The study aimed to see H. pylori positivity rate in patients of functional dyspepsia and the effect of its eradication on symptoms.
  
  
  METHODS
  Randomized, double-blind, placebo-controlled study was the study design used. Patients of functional dyspepsia defined as per Rome 2 criteria were tested for H. pylori infection by rapid urease test and gastric biopsy. H. pylori-positive patients were randomly allocated to triple therapy (20 mg of omeprazole, 500 mg of clarithromycin, and 1000 mg of amoxicillin orally two times daily) and omeperazole plus identical placebo for 2 weeks. Symptoms were assessed with the weekly Likert scale.
  
  
  RESULTS
  H. pylori positivity rate in functional dyspepsia was 1160/2000 (58%). At 6 weeks, the eradication rate for H. pylori in triple therapy and placebo group was (181/259 [69.8%] and 13/260 [5.0%], P = 0.001), respectively. On intention-to-treat analysis, the symptom resolution at 1 month was (157/259 [60.7%] and 136/260 [52.3%], P = 0.38), respectively. At 12 months, H. pylori eradication and healing of gastritis in triple therapy and placebo group were (116/174 [66.7%] and 12/180 [6.7%], P = 0.001) and (132/174 [75.9%] and 11/180 [6.1%], P = 0.001), respectively. On intension to treat, the resolution of symptoms in triple therapy and placebo group was (95/217 [43.7%] and 72/195 [36.9%], P = 0.13).
  
  
  CONCLUSIONS
  There is high H. pylori positivity rate in patients of functional dyspepsia. The eradication of H. pylori does not resolve the symptoms despite healing of gastritis.
authors: Department of Gastroenterology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India. jassi_win@rediffmail.com
authors: Jaswinder Singh
authors: JS
authors: Sodhi
authors: Gul
authors: G
authors: Javid
authors: Showkat Ali
authors: SA
authors: Zargar
authors: Syed
authors: S
authors: Tufail
authors: Altaf
authors: A
authors: Shah
authors: Bashir Ahmad
authors: BA
authors: Khan
authors: Ghulam Nabi
authors: GN
authors: Yattoo
authors: Ghulam Mohamad
authors: GM
authors: Gulzar
authors: Mushtaq Ahmad
authors: MA
authors: Khan
authors: Mohd Iqbal
authors: MI
authors: Lone
authors: Riyaz u
authors: Ru
authors: Saif
authors: Shaheena
authors: S
authors: Parveen
authors: Abid
authors: A
authors: Shoukat
mesh_terms: D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004415:Dyspepsia / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005759:Gastroenteritis / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult