title: Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating Slug.
abstract: Sox2 is a major transcription factor essential to the stemness characteristics and is associated with various types of cancers. In this study, we investigated the expressions and functional roles of Sox2 in hepatocellular carcinoma (HCC). Our data show that high level of Sox2 expression correlates with metastasis and low survival rate in HCC. HCC cells overexpressing Sox2 are characterized by active epithelial-mesenchymal transition and exhibit increased ability of transwell invasion, soft agar colonization, and sphere formation. We also found Sox2 expression was correlated with the transcription activity of SLUG promoter region. These results present novel mechanistic insight into an important role of Sox2 in HCC and suggest a potential application of Sox2 in HCC prognosis and treatment.
authors: Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Chun
authors: C
authors: Sun
authors: Lu
authors: L
authors: Sun
authors: Yan
authors: Y
authors: Li
authors: Xiaonan
authors: X
authors: Kang
authors: Shu
authors: S
authors: Zhang
authors: Yinkun
authors: Y
authors: Liu
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D011237:Predictive Value of Tests; D055748:SOXB1 Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D000071250:Snail Family Transcription Factors; D015996:Survival Rate / Q000639:trends; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C000604407:SNAI1 protein, human; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors