title: p53-mediated autophagy adjustment is involved in the protection of silibinin against murine dermal inflammation and epidermal apoptosis induced by UVB irradiation.
abstract: Apoptosis in murine dermal cells is retarded by ultraviolet B (UVB) irradiation-induced autophagic intervention while simultaneously epidermal cells commit apoptosis, during which inflammatory cytokines released from the lost epidermal cells promote immune responses of dermal inflammatory cells, forming morphological symptoms of acute cutaneous diseases. Autophagy is involved in prevention or provocation of apoptosis of dermal or epidermal cells of UVB-irradiated mice via modulation of intracellular metabolism, intervening the balance between cell death and survival in dermis and epidermis. p53 expressed in immune system affects autophagy function through activating or inactivating genes encoding apoptotic factors and inflammatory cytokines. Silibinin protects dermal and epidermal cells of UVB irradiated skin against abnormally autophagy-mediated apoptosis adjustments. In this study, how UVB irradiation intervenes autophagy in dermal and epidermal cells as well as how silibinin protects UVB irradiated skin through physiological recovering of autophagy function in dermis and epidermis are focused and elucidated preliminarily. Silibinin treatment (50 mg/kg/day for 4 days) reversed dermal and epidermal autophagy levels from UVB irradiation-induced improper autophagy intervention, repaired the balance between cell survival and death in dermis and epidermis, and protected skin against damage through mediation of p53 activation in dermal and epidermal cells.
authors: China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors: Qiong
authors: Q
authors: Wang
authors: Weiwei
authors: W
authors: Liu
authors: Hong
authors: H
authors: Zeng
authors: Xuqin
authors: X
authors: Xie
authors: Guangxi
authors: G
authors: Zang
authors: Yuanchao
authors: Y
authors: Ye
authors: Shin-ichi
authors: S
authors: Tashiro
authors: Satoshi
authors: S
authors: Onodera
authors: Shan
authors: S
authors: Jiang
authors: Takashi
authors: T
authors: Ikejima
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000528:radiation effects; D001343:Autophagy / Q000235:genetics / Q000528:radiation effects*; D004817:Epidermis / Q000378:metabolism / Q000528:radiation effects*; D004847:Epithelial Cells / Q000378:metabolism; D007249:Inflammation / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D000077385:Silybin; D012838:Silymarin / Q000097:blood / Q000737:chemistry / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D012838:Silymarin; D016159:Tumor Suppressor Protein p53; D000077385:Silybin