title: Modulation of inflammatory bowel disease in a mouse model following infection with Trichinella spiralis.
abstract: Infection of mice with Trichinella spiralis redirects the mucosal immune system from a Th1 to a protective Th2 response with a reduction in the severity of trinitrobenzesulfonic acid-induced colonic damage. T. spiralis infection induced IL-10 production in a dose-dependent manner in oxazolone (OXZ)-induced colitis. This phenomenon may be responsible for the lack of efficacy of T. spiralis in the treatment of OXZ-induced colitis. These results indicate that if the source of increased IL-10 production is identified and addressed, T. spiralis may alter the Th2 response.
authors: Key Lab for Zoonosis Research, Ministry of Education, First Hospital, Jilin University, Changchun 130062, PR China.
authors: Y
authors: Y
authors: Zhao
authors: M Y
authors: MY
authors: Liu
authors: X L
authors: XL
authors: Wang
authors: X L
authors: XL
authors: Liu
authors: Y
authors: Y
authors: Yang
authors: H B
authors: HB
authors: Zou
authors: S M
authors: SM
authors: Sun
authors: L
authors: L
authors: Yu
authors: B
authors: B
authors: Rosenthal
authors: H N
authors: HN
authors: Shi
authors: P
authors: P
authors: Boireau
authors: X P
authors: XP
authors: Wu
mesh_terms: D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D003106:Colon / Q000276:immunology / Q000473:pathology; D016207:Cytokines / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D007155:Immunologic Factors / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D017160:Trichinella spiralis / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology*
chemical_list: D016207:Cytokines; D007155:Immunologic Factors