title: Pyridine to aniline: an exceptional biologically driven rearrangement.
abstract: During the course of our study on the innovative ligand for nicotinic acetylcholinergic receptors, LNAChR, and in order to assess activity and toxicity profiles of the drug's metabolites, synthesis of the main metabolites was undertaken. This synthesis work was done in parallel by organic chemistry and by biotransformation of LNAChR. Filamentous fungus Aspergillus alliaceus (NRRL 315) neatly afforded three of the main metabolites, one of which arose from a very unexpected and very uncommon rearrangement.
authors: Synthesis Department, Technologie Servier, 27 Rue Eugène Vignat, 45000 Orléans, France. thomas.arnauld@fr.netgrs.com
authors: Thomas
authors: T
authors: Arnauld
authors: Jean-Yves
authors: JY
authors: Beaumal
authors: François
authors: F
authors: Lefoulon
authors: Alain
authors: A
authors: Petit
authors: Tristan
authors: T
authors: Renaud
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry / Q000378:metabolism*; D001230:Aspergillus / Q000378:metabolism; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism
chemical_list: D000814:Aniline Compounds; D011725:Pyridines; D011978:Receptors, Nicotinic; C023666:pyridine; C023650:aniline