title: Effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B and Tau phosphorylation in hippocampus of rats.
abstract: OBJECTIVE
  To study the effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B (NR2B) and tau phosphorylation in hippocampus of rats.
  
  
  METHODS
  Twenty-four male SD rats were divided in control group and chronic noise exposure group. NR2B expression and tau phosphorylation in hippocampus of rats were detected after chronic noise exposure (100 dB SPL white noise, 4 h/d×30d) and their mechanisms underlying neuronal apoptosis in hippocampus of rats with TUNEL staining.
  
  
  RESULTS
  The NR2B expression decreased significantly after chronic noise exposure which resulted in tau hyperphosphorylation and neural apoptosis in hippocampus of rats. Immunohistochemistry showed that the tau hyperphosphorylation was most prominent in dentate gyrus (DG) and CA1 region of rat hippocampus.
  
  
  CONCLUSIONS
  The abnormality of neurotransmitter system, especially Glu and NR2B containing NMDA receptor, and tau hyperphosphorylation in hippocampus of rats, may play a role in chronic noise-induced neural apoptosis and cognition impairment.
authors: Department of Occupational Hygiene, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China. iamcuib@sina.com
authors: Bo
authors: B
authors: Cui
authors: Ming Quan
authors: MQ
authors: Wu
authors: Li Xing
authors: LX
authors: Zhu
authors: Xiao Jun
authors: XJ
authors: She
authors: Qiang
authors: Q
authors: Ma
authors: Hong Tao
authors: HT
authors: Liu
mesh_terms: D000818:Animals; D017209:Apoptosis; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009622:Noise / Q000009:adverse effects*; D010766:Phosphorylation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D016875:tau Proteins / Q000378:metabolism*
chemical_list: C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate; D016875:tau Proteins
keywords: Apoptosis; N-methyl-D-aspartic acid receptor 2B subunit; Noise; Tau hyperphosphorylation