title: Single and 90-day repeated oral dose toxicity studies of fermented Rhus verniciflua stem bark extract in Sprague-Dawley rats.
abstract: Fermented Rhus verniciflua stem bark (FRVSB) extract, an urushiol-free extract of Rhus verniciflua Stokes (RVS) fermented with Fomitella fraxinea, has various biological activities. The present study was carried out to investigate the potential toxicity of the FRVSB extract following single and repeated oral administration to Sprague-Dawley rats. In the single dose toxicity study, the FRVSB extract was administered orally to male and female rats at single doses of 0, 2500, 5000, and 10,000mg/kg. No animals died and no toxic changes were observed in clinical signs, body weight, and necropsy findings during the 15-day period following administration. In the repeated dose toxicity study, the FRVSB extract was administered orally to male and female rats for 90days at doses of 0, 556, 1667, and 5000mg/kg/day. There were no treatment-related adverse effects in clinical signs, body weight, food and water consumption, ophthalmic examination, urinalysis, hematology, serum biochemistry, necropsy findings, organ weight, and histopathology at any dose tested. The approximate lethal dose of the FRVSB extract was >10,000mg/kg in both genders, the oral no-observed-adverse-effect level of the FRVSB extract was >5000mg/kg/day in both genders, and no target organs were identified.
authors: Preclinical Research Center, ChemOn Inc., 334 Jeil-ri, Yangji-myeon, Cheoin-gu, Yongin-si, Gyeonggi-do 449-826, Republic of Korea.
authors: Seo-Ho
authors: SH
authors: Shin
authors: Kyo-Hwan
authors: KH
authors: Koo
authors: Jin-Sook
authors: JS
authors: Bae
authors: Seung-Bum
authors: SB
authors: Cha
authors: In-Soo
authors: IS
authors: Kang
authors: Min-Soo
authors: MS
authors: Kang
authors: Hak-Soo
authors: HS
authors: Kim
authors: Hyun-Suk
authors: HS
authors: Heo
authors: Min-Su
authors: MS
authors: Park
authors: Gi-Hyun
authors: GH
authors: Gil
authors: Joo-Young
authors: JY
authors: Lee
authors: Kap-Ho
authors: KH
authors: Kim
authors: Yinghua
authors: Y
authors: Li
authors: Hyun-Kul
authors: HK
authors: Lee
authors: Si-Whan
authors: SW
authors: Song
authors: Han-Seok
authors: HS
authors: Choi
authors: Boo-Hyon
authors: BH
authors: Kang
authors: Jong-Choon
authors: JC
authors: Kim
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005285:Fermentation; D008297:Male; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D029045:Rhus / Q000737:chemistry*
chemical_list: D010936:Plant Extracts