title: Treatment modification of yttrium-90 radioembolization based on quantitative positron emission tomography/CT imaging.
abstract: Treatment activity for yttrium-90 ((90)Y) radioembolization when calculated by using the manufacturer-recommended technique is only partially patient-specific and may result in a subtumoricidal dose in some patients. The authors describe the use of quantitative (90)Y positron emission tomography/computed tomography as a tool to provide patient-specific optimization of treatment activity and evaluate this new method in a patient who previously received traditional (90)Y radioembolization. The modified treatment resulted in a 40-Gy increase in absorbed dose to tumor and complete resolution of disease in the treated area within 3 months.
authors: Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA.
authors: Ted T
authors: TT
authors: Chang
authors: Austin C
authors: AC
authors: Bourgeois
authors: Anastasia M
authors: AM
authors: Balius
authors: Alexander S
authors: AS
authors: Pasciak
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects*; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D011879:Radiotherapy Dosage; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015019:Yttrium / Q000008:administration & dosage*
chemical_list: D019275:Radiopharmaceuticals; D015019:Yttrium