title: Relationship between total thiol status and thrombocytopenia in patients with Crimean-Congo hemorrhagic fever.
abstract: The objective of this study was to investigate the relationship between serum total thiol level and total oxidant status (TOS) and thrombocytopenia among patients with Crimean-Congo hemorrhagic fever (CCHF). Eighty-three subjects and 56 controls were enrolled in the study. Thiol levels were measured with the DTNB method and TOS was measured with the Erel's method among subjects and controls. Thiol levels were lower in subjects than controls and TOS levels were higher in subjects than controls. There was a significant correlation between total thiol levels and platelet counts (r = 0.84, p < 0.0001) among subjects. Further investigations are needed into the link between total thiol level and TOS and the pathogenesis of hemorrhage in CCHF.
authors: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
authors: Rahmet
authors: R
authors: Guner
authors: Mehmet A
authors: MA
authors: Tasyaran
authors: Siran
authors: S
authors: Keske
authors: Imran
authors: I
authors: Hasanoglu
authors: Ayse Kaya
authors: AK
authors: Kalem
authors: Derya
authors: D
authors: Yapar
authors: Tugba Arslan
authors: TA
authors: Gulen
authors: Salim
authors: S
authors: Neselioglu
authors: Semra
authors: S
authors: Isikoglu
authors: Ozcan
authors: O
authors: Erel
mesh_terms: D016022:Case-Control Studies; D004228:Dithionitrobenzoic Acid; D005260:Female; D006479:Hemorrhagic Fever, Crimean / Q000097:blood* / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D010976:Platelet Count; D012372:ROC Curve; D013438:Sulfhydryl Compounds / Q000097:blood*; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology*; D014421:Turkey
chemical_list: D016877:Oxidants; D013438:Sulfhydryl Compounds; D004228:Dithionitrobenzoic Acid