title: Uncoupling protein-2 gene polymorphisms are associated with obesity in Hungarian children.
abstract: OBJECTIVE
  To determine the frequency of common polymorphisms of genes associated with energy metabolism among normal weight and overweight/obese children to look for effects on childhood obesity.
  
  
  METHODS
  Among 709 overweight/obese and 637 normal weight children (age 6-17 years), anthropometric measurements were carried out and genotyping for the following gene polymorphisms: β3 -adrenoreceptor Trp64Arg, uncoupling protein (UCP) -1 -3826 A/G, UCP-2 -866 G/A and exon 8 del/ins, UCP-3 -55 C/T and peroxisome proliferator-activated receptor-γ Pro12Ala.
  
  
  RESULTS
  On multivariate regression analysis adjusted for age and gender heterozygosity and homozygosity for the UCP-2 -866 A variant was associated with an odds ratio (OR) for obesity of 0.69 (95% CI: 0.52-0.92; p = 0.013) and 0.50 (95% CI: 0.32-0.79; p = 0.003), respectively, compared with G/G homozygotes. Heterozygotes and homozygotes for the UCP-2 exon 8 ins allele had an OR for obesity of 1.66 (95% CI: 1.24-2.23; p = 0.001) and 2.12 (95% CI: 1.23-3.63; p = 0.006), respectively, compared with del/del homozygotes. There were no significant differences in obesity risk in association with the other examined gene polymorphisms.
  
  
  CONCLUSIONS
  Common polymorphisms of the UCP-2 gene might influence the propensity to overweight/obesity in Hungarian children.
authors: Department of Pediatrics, Medical Faculty, University of Pecs, Pecs, Hungary. cs-kata@freemail.hu
authors: K
authors: K
authors: Csernus
authors: G
authors: G
authors: Pauler
authors: E
authors: E
authors: Erhardt
authors: E
authors: E
authors: Lanyi
authors: D
authors: D
authors: Molnar
mesh_terms: D000293:Adolescent; D002648:Child; D004734:Energy Metabolism; D006801:Humans; D006814:Hungary; D007473:Ion Channels / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D000071246:Uncoupling Protein 2
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2