title: Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity.
abstract: A total of eight new analogs of pactamycin were prepared and tested alongside pactamycin and three of its natural congeners for antibacterial, anticancer, and antiprotozoal activities. The present study highlights the effects of changing the urea and aniline groups especially with regard to anticancer and antiprotozoal activities.
authors: Department of Chemistry, Université de Montréal, Station Centre Ville, CP 6128, Montréal, Qc, Canada H3C 3J7. stephen.hanessian@umontreal.ca
authors: Stephen
authors: S
authors: Hanessian
authors: Ramkrishna Reddy
authors: RR
authors: Vakiti
authors: Amit Kumar
authors: AK
authors: Chattopadhyay
authors: Stéphane
authors: S
authors: Dorich
authors: Christian
authors: C
authors: Lavallée
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D045744:Cell Line, Tumor; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D010142:Pactamycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D010142:Pactamycin