title: Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug.
abstract: Two new small compounds, which undergo fluoride-mediated self rearrangement, produce active DNA alkylating agent nitrogen mustard leading to DNA damage and finally cell death, providing potential antitumor prodrugs.
authors: College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430072, PR of China.
authors: Jun
authors: J
authors: Wu
authors: Rong
authors: R
authors: Huang
authors: Tianlu
authors: T
authors: Wang
authors: Xi
authors: X
authors: Zhao
authors: Wanyi
authors: W
authors: Zhang
authors: Xiaocheng
authors: X
authors: Weng
authors: Tian
authors: T
authors: Tian
authors: Xiang
authors: X
authors: Zhou
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects*; D015180:Electrophoresis, Gel, Two-Dimensional; D005459:Fluorides / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D011355:Prodrugs; D004247:DNA; D005459:Fluorides