title: Antisynthetase antibody syndrome: case report and review of the literature.
abstract: Antisynthetase antibody syndrome is a rare autoimmune disease that may present with variable systemic manifestations, mainly polymyositis, interstitial lung disease, skin lesions, and Raynaud's phenomenon. This diagnosis should always come to mind in patients that present with signs of myositis, dermatomyositis, or polymyositis associated with interstitial lung disease. On the following paper, we report the case of a 52-year-old man who presented with a 2-month history of asymmetric polyarthralgia, myalgia, weight loss of 8 kg, and progressive muscle weakness associated with dyspnea, orthopnea, and dysphonia. Further tests revealed myositis, interstitial pneumonia, and elevation of anti-Jo-1 antibodies. A diagnosis of antisynthetase antibody syndrome was made and the patient showed good response to treatment with corticoids and methotrexate. Finally, we present a short review of the literature.
authors: Department of Internal Medicine, Faculty of Medicine, Fundación Universitaria de Ciencias de Salud, Bogotá, Colombia.
authors: Laura
authors: L
authors: Uribe
authors: Diana Maria
authors: DM
authors: Ronderos
authors: Maria Claudia
authors: MC
authors: Díaz
authors: Juan Martín
authors: JM
authors: Gutierrez
authors: Christina
authors: C
authors: Mallarino
authors: Daniel Gerardo
authors: DG
authors: Fernandez-Avila
mesh_terms: D000974:Antibodies, Antinuclear / Q000276:immunology; D018771:Arthralgia / Q000175:diagnosis; D001706:Biopsy; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000175:diagnosis; D009132:Muscles / Q000473:pathology; D063806:Myalgia / Q000175:diagnosis; D009220:Myositis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D000974:Antibodies, Antinuclear; C046750:Jo-1 antibody