title: New steroids from the soft coral Nephthea chabrolii.
abstract: A new cytotoxic 19-oxygenated steroid, nebrosteroid Q(1) and two new cytotoxic 19-norergosterols, nebrosteroids R and S (2 and 3) were isolated from the soft coral Nephthea chabrolii collected at San-Hsian-Tai. The structures of nebrosteroids Q-S (1-3) were elucidated by spectral analysis, and their cytotoxicity against selected cancer cells as well as antiviral activity against human cytomegalovirus (HCMV) were measured in vitro.
authors: Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Shang-Kwei
authors: SK
authors: Wang
authors: Shyh-Yueh
authors: SY
authors: Puu
authors: Chang-Yih
authors: CY
authors: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry / Q000378:metabolism*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D013256:Steroids / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000998:Antiviral Agents; D013256:Steroids; C583598:nebrosteroid Q; C583599:nebrosteroid R; C583600:nebrosteroid S