title: Selective O-difluoromethylation of 1,3-diones by bromodifluoromethylating reagents.
abstract: The regioselective O-difluoromethylation of 1,3-diones was achieved via in situ generation of difluorocarbene from bromodifluoromethylating reagents in the presence of an organic base. A wide variety of difluormethyl enol ethers were obtained in good to excellent yields. The reaction mechanism is discussed based on ab initio calculations (kcal/mol).
authors: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, Japan.
authors: Guokai
authors: G
authors: Liu
authors: Xin
authors: X
authors: Wang
authors: Xiu-Hua
authors: XH
authors: Xu
authors: Xu
authors: X
authors: Lu
authors: Etsuko
authors: E
authors: Tokunaga
authors: Seiji
authors: S
authors: Tsuzuki
authors: Norio
authors: N
authors: Shibata
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D013816:Thermodynamics
chemical_list: D004987:Ethers; D006842:Hydrocarbons, Brominated; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; C121084:difluorocarbene