title: Networking development by Boolean logic.
abstract: Eric Davidson at Caltech has spent several decades investigating the molecular basis of animal development using the sea urchin embryo as an experimental system although his scholarship extends to all of embryology as embodied in several editions of his landmark book. In recent years his laboratory has become a leading force in constructing gene regulatory networks (GRNs) operating in sea urchin development. This axis of his work has its roots in this laboratory's cDNA cloning of an actin mRNA from the sea urchin embryo (for the timeline, see ref. 1)--one of the first eukaryotic mRNAs to be cloned as it turned out. From that point of departure, the Davidson lab has drilled down into other genes and gene families and the factors that regulate their coordinated regulation, leading them into the GRN era (a field they helped to define) and the development of the computational tools needed to consolidate and advance the GRN field.
authors: Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA.
authors: Shikui
authors: S
authors: Tu
authors: Thoru
authors: T
authors: Pederson
authors: Zhiping
authors: Z
authors: Weng
mesh_terms: D000199:Actins / Q000235:genetics; D000818:Animals; D019295:Computational Biology; D053263:Gene Regulatory Networks; D012333:RNA, Messenger / Q000235:genetics; D012617:Sea Urchins / Q000196:embryology* / Q000235:genetics*; D060449:Wnt Signaling Pathway / Q000235:genetics
chemical_list: D000199:Actins; D012333:RNA, Messenger
keywords: computational embryology; development; gene regulatory networks; sea urchin; specification