title: Importance of tuberculosis screening before inhibiting tumour necrosis factor-alpha therapy.
abstract: BACKGROUND
  There has been an increase in the incidence of tuberculosis infection in recent years, due to the increasing use of drugs inhibiting tumour necrosis factor-alpha (anti-TNFα) in the treatment of inflammatory diseases.
  
  
  METHODS
  We report the case of a male patient being treated with infliximab (anti-TNFα) who developed disseminated tuberculosis with ocular involvement.
  
  
  CONCLUSIONS
  It is very important to conduct a proper screening to detect patients at risk for tuberculosis before starting treatment with these drugs. For this purpose, the QuantiFERON®-TB Gold in Tube (Interferon Gamma Release Assay, IGRA) is presented as an alternative screening test with high sensitivity and specificity.
authors: Servicio de Oftamología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain. albagarlo@hotmail.com
authors: A
authors: A
authors: García-López
authors: C
authors: C
authors: Burgueño-Montañés
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D006801:Humans; D000069285:Infliximab; D055985:Latent Tuberculosis / Q000175:diagnosis*; D008297:Male; D014392:Tuberculosis, Ocular / Q000139:chemically induced*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab