title: Potentially-toxic and essential elements profile of AH1N1 patients in Mexico City.
abstract: During spring of 2009, a new influenza virus AH1N1 spread in the world causing acute respiratory illness and death, resulting in the first influenza pandemic since 1968. Blood levels of potentially-toxic and essential elements of 40 pneumonia and confirmed AH1N1 were evaluated against two different groups of controls, both not infected with the pandemic strain. Significant concentrations of potentially-toxic elements (lead, mercury, cadmium, chromium, arsenic) along with deficiency of selenium or increased Zn/Cu ratios characterized AH1N1 cases under study when evaluated versus controlled cases. Deficiency of selenium is progressively observed from controls I (influenza like illness) through controls II (pneumonia) and finally pneumonia-AH1N1 infected patients. Cases with blood Se levels greater than the recommended for an optimal cut-off to activate glutathione peroxidase (12.5 μg/dL) recovered from illness and survived. Evaluation of this essential element in critical pneumonia patients at the National Institutes is under evaluation as a clinical trial.
authors: National Institute for Respiratory Diseases-Mexico, Mexico. mmoya@unam.mx
authors: Mireya
authors: M
authors: Moya
authors: Edgar G
authors: EG
authors: Bautista
authors: Antonio
authors: A
authors: Velázquez-González
authors: Felipe
authors: F
authors: Vázquez-Gutiérrez
authors: Guadalupe
authors: G
authors: Tzintzun
authors: María Elena
authors: ME
authors: García-Arreola
authors: Manuel
authors: M
authors: Castillejos
authors: Andrés
authors: A
authors: Hernández
mesh_terms: D000328:Adult; D001151:Arsenic / Q000097:blood; D002104:Cadmium / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification; D007251:Influenza, Human / Q000097:blood* / Q000453:epidemiology / Q000821:virology; D007854:Lead / Q000097:blood; D008297:Male; D008628:Mercury / Q000097:blood; D008670:Metals / Q000097:blood*; D008800:Mexico; D008875:Middle Aged; D058873:Pandemics; D011014:Pneumonia / Q000097:blood / Q000175:diagnosis; D012643:Selenium / Q000097:blood; D055815:Young Adult
chemical_list: D008670:Metals; D002104:Cadmium; D007854:Lead; D005979:Glutathione Peroxidase; D008628:Mercury; D012643:Selenium; D001151:Arsenic