title: Application of physicochemical properties and process parameters in the development of a neural network model for prediction of tablet characteristics.
abstract: The importance of in silico modeling in the pharmaceutical industry is continuously increasing. The aim of the present study was the development of a neural network model for prediction of the postcompressional properties of scored tablets based on the application of existing data sets from our previous studies. Some important process parameters and physicochemical characteristics of the powder mixtures were used as training factors to achieve the best applicability in a wide range of possible compositions. The results demonstrated that, after some pre-processing of the factors, an appropriate prediction performance could be achieved. However, because of the poor extrapolation capacity, broadening of the training data range appears necessary.
authors: Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6., 6720 Szeged, Hungary.
authors: Tamás
authors: T
authors: Sovány
authors: Kitti
authors: K
authors: Papós
authors: Péter
authors: P
authors: Kása
authors: Ilija
authors: I
authors: Ilič
authors: Stane
authors: S
authors: Srčič
authors: Klára
authors: K
authors: Pintye-Hódi
mesh_terms: D000465:Algorithms; D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D003198:Computer Simulation; D007785:Lactose / Q000737:chemistry; D008353:Mannitol / Q000737:chemistry; D008956:Models, Chemical; D016571:Neural Networks, Computer; D010208:Papaverine / Q000031:analogs & derivatives / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011208:Powders; D013229:Stearic Acids / Q000737:chemistry; D013499:Surface Properties; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D013718:Tensile Strength
chemical_list: D004364:Pharmaceutical Preparations; D011208:Powders; D013229:Stearic Acids; D013607:Tablets; C477445:vivapur; D008353:Mannitol; C031183:stearic acid; D002482:Cellulose; C005317:drotaverin; D010208:Papaverine; D007785:Lactose