title: The relation of serum γ-glutamyl transferase levels and coronary collateral circulation in patients with chronic coronary total occlusion.
abstract: OBJECTIVE
  Sufficient coronary collateral circulation (CCC) protects myocardial tissue against ischemia in patients with coronary chronic total occlusion (CTO). In this study, we aimed to investigate whether there is an association between serum γ-glutamyl transferase (GGT) levels and development of CCC in patients with coronary CTO.
  
  
  METHODS
  A total of 203 patients with CTO at coronary angiography were included in this study. On the day of admission to the hospital, blood samples were taken and GGT levels were analyzed for all patients. Development of collateral circulation was graded according to the Rentrop classification after coronary angiography. Then, patients were divided into two groups on the basis of CCC grades: group 1 included 99 patients (49%) with poorly developed CCC, and group 2 included 104 patients (51%) with well-developed CCC.
  
  
  RESULTS
  Patients with poorly developed CCC had significantly higher serum GGT levels compared with those with well-developed CCC, (66.5±16 vs. 51.8±10 U/l, P<0.0001). Correlation analysis showed an inverse correlation between GGT levels and the Rentrope score (r=-0.579, P<0.001). Logistic regression analysis showed that GGT level was an independent predictor of poorly developed CCC (odds ratio 0.92, 95% confidence interval 0.90-0.94; P<0.001).
  
  
  CONCLUSIONS
  Increased serum GGT levels independently predict poorly developed CCC in patients with coronary CTO. Our results show that GGT is a simple and readily available marker for sufficiency of CCC in patients with CTO.
authors: Department of Cardiology, Kayseri Education and Research Hospital, 38010 Kayseri, Turkey. drsarli@yahoo.com
authors: Bahadir
authors: B
authors: Sarli
authors: Ahmet O
authors: AO
authors: Baktir
authors: Hayrettin
authors: H
authors: Saglam
authors: Huseyin
authors: H
authors: Arinc
authors: Serkan
authors: S
authors: Kurtul
authors: Mahmut
authors: M
authors: Akpek
authors: Mehmet G
authors: MG
authors: Kaya
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003097:Collateral Circulation; D017023:Coronary Angiography; D003326:Coronary Circulation; D054059:Coronary Occlusion / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D005723:gamma-Glutamyltransferase
chemical_list: D015415:Biomarkers; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human