title: Effectiveness of a calcium sodium phosphosilicate-containing prophylaxis paste in reducing dentine hypersensitivity immediately and 4 weeks after a single application: a double-blind randomized controlled trial.
abstract: OBJECTIVE
  The aim of this single-site, randomized, controlled, double-blind, 3-arm parallel study was to determine the effectiveness of a prophylaxis paste containing 15% calcium sodium phosphosilicate (CSPS; NovaMin(®) ) with and without fluoride in reducing dentine hypersensitivity immediately after a single application and 28 days following dental scaling and root planing.
  
  
  METHODS
  Overall, 151 subjects were enrolled in this study. All subjects received a scaling and root planing procedure followed by a final prophylaxis step using one of three different prophylaxis pastes: Test-A (15% NovaMin(®) and NaF), Test-B (15% NovaMin(®) ) and a control. Dentine hypersensitivity was assessed by tactile stimulus (Yeaple Probe(®) ) and by air blast (Schiff scale) at baseline, immediately after and 28 days after a prophylaxis procedure. One hundred and forty-nine subjects completed the study.
  
  
  RESULTS
  Subjects having received the test prophylaxis pastes showed statistically lower (anova, p < 0.05) dentine hypersensitivity compared with the control group immediately after the prophylaxis procedure (Yeaple Probe(®) : Test-A = 20.9 ± 12.6, Test-B = 22.7 ± 12.9, Control=11.2 ± 3.1; Schiff score: Test-A = 1.1 ± 0.6, Test-B = 1.1 ± 0.6, Control = 2.0 ± 0.7) and after 28 days (Yeaple probe: Test-A = 21.5 ± 11.9, Test-B = 20.6 ± 11.3, Control = 11.8 ± 6.0; Schiff score: Test-A = 1.0 ± 0.6, Test-B = 1.0 ± 0.6, Control = 2.0 ± 0.7).
  
  
  CONCLUSIONS
  In conclusion, the single application of both fluoridated and non-fluoridated prophylaxis pastes containing 15% CSPS (NovaMin(®) ) provided a significant reduction of dentine hypersensitivity up to at least 28 days.
authors: Department of Preventive, Restorative and Pediatric Dentistry, School of Dental Medicine, University of Bern, Bern, Switzerland.
authors: Klaus W
authors: KW
authors: Neuhaus
authors: Jeffery L
authors: JL
authors: Milleman
authors: Kimberly R
authors: KR
authors: Milleman
authors: Kimberly A
authors: KA
authors: Mongiello
authors: Thomas C
authors: TC
authors: Simonton
authors: Courtney E
authors: CE
authors: Clark
authors: Howard M
authors: HM
authors: Proskin
authors: Rainer
authors: R
authors: Seemann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003777:Dental Prophylaxis / Q000379:methods*; D012534:Dental Scaling / Q000009:adverse effects / Q000379:methods; D057133:Dentin Desensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000209:etiology / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005898:Glass / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D012969:Sodium Fluoride / Q000627:therapeutic use; D011795:Surveys and Questionnaires; D013997:Time Factors; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D057133:Dentin Desensitizing Agents; C510984:NovaMin; D014100:Toothpastes; D012969:Sodium Fluoride