title: [Current situation and prospect of tenomodulin in tendon tissue engineering].
abstract: OBJECTIVE
  To review the latest researches of Tenomodulin in tendon tissue engineering, to predict the progress of research and application of Tenomodulin.
  
  
  METHODS
  The literature concerning Tenomodulin in tendon tissue engineering was collected and analyzed.
  
  
  RESULTS
  Tenomodulin is a type II transmembrane glycoprotein that can regulate growth of tendon and contains a C-terminal anti-angiogenic domain. The human Tenomodulin gene spans approximately 1360 bp and is mapped to Xq22.1. The expression of Tenomodulin is regulated by various biological factors, especially Scleraxis; and the nature and structure of scaffold material as well as the stain loading and cell passage, can modulate the expression of Tenomodulin.
  
  
  CONCLUSIONS
  Tenomodulin, as relatively specific molecule makers for tendon and containing a C-terminal anti-angiogenic domain, is expected to play a significant role in tendon tissue engineering.
authors: Department of Orthopedics, the 1st Affiliated Hospital of Harbin Medical University, Harbin Heilongjiang, 150001, PR China.
authors: Cewen
authors: C
authors: Guan
authors: Xing
authors: X
authors: Lei
authors: Yang
authors: Y
authors: Song
authors: Yanlong
authors: Y
authors: Qu
mesh_terms: D020533:Angiogenesis Inhibitors / Q000235:genetics / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002478:Cells, Cultured; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D008969:Molecular Sequence Data; D013710:Tendons / Q000166:cytology / Q000378:metabolism*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D020533:Angiogenesis Inhibitors; D015415:Biomarkers; D016207:Cytokines; D008565:Membrane Proteins