title: Retinal vascular caliber is associated with renal function in apparently healthy subjects.
abstract: OBJECTIVE
  To assess the relation between retinal vascular caliber and renal function.
  
  
  METHODS
  Eighty apparently healthy subjects screened for cardiovascular risk factors (mean age 47 years, 51% female, 36% hypertensive, without diabetes or renal dysfunction) were recruited. Retinal vascular calibers were measured from fundus photographs and expressed as central retinal artery and venular equivalent. Renal function was assessed by measurement of glomerular filtration rate (urinary clearance of 99mTc-DTPA) and urinary albumin/creatinine ratio.
  
  
  RESULTS
  Mean glomerular filtration rate was 117 ml/min/1.73m(2). Overall, central retinal artery and venular equivalent were positively correlated with glomerular filtration rate (r = +0.31, p = 0.005 and r = +0.30, p = 0.006, respectively). In addition, central retinal artery equivalent was negatively correlated with urinary albumin/creatinine ratio (r = -0.34, p = 0.002). No significant relationship was found between central retinal venular equivalent and urinary albumin/creatinine ratio (r = +0.12, p = 0.32). The observed relations between retinal vascular calibers and renal function parameters remained significant after adjusting for potential confounding factors.
  
  
  CONCLUSIONS
  In apparently healthy subjects with normal renal function, retinal arteriolar and venular calibers were negatively correlated with kidney function, suggesting common determinants of these preclinical target organ damages.
authors: Department of Opthalmology, Hôpital Gui de Chauliac, Montpellier, France. vincent.daien@gmail.com
authors: Vincent
authors: V
authors: Daien
authors: Ryo
authors: R
authors: Kawasaki
authors: Max
authors: M
authors: Villain
authors: Jean
authors: J
authors: Ribstein
authors: Guilhem
authors: G
authors: Du Cailar
authors: Albert
authors: A
authors: Mimran
authors: Pierre
authors: P
authors: Fesler
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D003404:Creatinine / Q000097:blood*; D005260:Female; D005602:France / Q000453:epidemiology; D005654:Fundus Oculi; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology; D015994:Incidence; D007668:Kidney / Q000502:physiology*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010781:Photography; D011379:Prognosis; D012016:Reference Values; D012160:Retina / Q000502:physiology*; D012171:Retinal Vessels / Q000166:cytology* / Q000502:physiology; D055815:Young Adult
chemical_list: D003404:Creatinine