title: A comprehensive review on SAR of curcumin.
abstract: Curcumin, a natural diaryl heptanoid continues to be used as an alternative medicinal agent in many parts of South East Asia for treatment of many ailments. It can be usually obtained from substituted aryl aldehydes and acetylacetone and this route enables synthesis of a diverse set of curcumin analogues. Numerous analogues have been synthesized and tested by several researchers to investigate their activity against known biological targets and to improve upon the pharmacological and ADME profile by modifying substitutions on aromatic rings, β-diketone moiety and two flanking double bonds conjugated to the β-diketone moiety. Successful synthesis of such derivatives with modifications has resulted in the development of potential anticancer candidates that target various stages in cancer cell growth and development. Based on the evidences in modifications of these three functional elements, we have attempted to summarize the structure activity relationship of molecules which can be further utilized by researchers in medicinal chemistry in exploring the structure of curcumin.
authors: Department of Pharmaceutical Chemistry, Vaagdevi College of Pharmacy, Hanamkonda, Warangal-506001. sirimedchem@gmail.com.
authors: A Rajasekhar
authors: AR
authors: Reddy
authors: P
authors: P
authors: Dinesh
authors: A S
authors: AS
authors: Prabhakar
authors: K
authors: K
authors: Umasankar
authors: B
authors: B
authors: Shireesha
authors: M Bhagavan
authors: MB
authors: Raju
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D003474:Curcumin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity; D006801:Humans; D007659:Ketones / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007659:Ketones; D003474:Curcumin