title: Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity.
abstract: BACKGROUND
  An inverse correlation between serum 25-hydroxyvitamin D concentration and atopic dermatitis (AD) severity has been suggested.
  
  
  OBJECTIVE
  To determine if a statistically significant relationship exists between serum 25-hydroxyvitamin D concentration and AD severity.
  
  
  METHODS
  A cross-sectional study was conducted of patients with AD who were 1 to 18 years of age. An objective Severity Scoring of Atopic Dermatitis (SCORAD) and a serum 25-hydroxyvitamin D concentration were measured for each subject. Statistical analysis was performed using appropriate univariate tests and multivariable models.
  
  
  RESULTS
  Ninety-four of 97 enrolled subjects were included in the analysis. Vitamin D deficiency (25-hydroxyvitamin D <20 ng/mL) was present in 37 subjects (39%), insufficiency (25-hydroxyvitamin D 21-29 ng/mL) in 33 (35%), and sufficiency (25-hydroxyvitamin D ≥30 ng/mL) in 24 (26%). The correlation between 25-hydroxyvitamin D concentration and SCORAD was not significant (r = -0.001; P = .99). A multivariate model showed that a lower serum 25-hydroxyvitamin D concentration was significantly associated with age 3 years or older (P < .0001), black race (P < .0001), and winter season (P = .0084).
  
  
  CONCLUSIONS
  Limitations of this study include the inability to control for natural sunlight exposure, vitamin D intake, and AD treatment; in addition, only a single time point was captured.
  
  
  CONCLUSIONS
  Serum 25-hydroxyvitamin D concentration is not significantly correlated with AD severity in our pediatric population.
authors: Department of Dermatology, Division of Pediatric Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. ychiu@mcw.edu
authors: Yvonne E
authors: YE
authors: Chiu
authors: Peter L
authors: PL
authors: Havens
authors: Dawn H
authors: DH
authors: Siegel
authors: Omar
authors: O
authors: Ali
authors: Tao
authors: T
authors: Wang
authors: Kristen E
authors: KE
authors: Holland
authors: Sheila S
authors: SS
authors: Galbraith
authors: Valerie B
authors: VB
authors: Lyon
authors: Beth A
authors: BA
authors: Drolet
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D012720:Severity of Illness Index; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000453:epidemiology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D