title: Chitosan nanoparticles for melanoma cancer treatment by Photodynamic Therapy and electrochemotherapy using aminolevulinic acid derivatives.
abstract: For some time Photodynamic Therapy and electrochemotherapy have been used as alternative therapies against skin cancer. The primary aim of this work was to develop, characterize, and evaluate the in vitro cytotoxic activity of new drug delivery systems based on chitosan nanoparticles containing aminolevulinic acid derivatives such as prodrug (5-ALA and its ester derivative 8-ALA). The second goal of this study was to evaluate the synergistic effect of a combination of classical Photodynamic Therapy and electrochemotherapy, which is routinely utilized to modulate and enhance the permeation of photosensitizers, prodrugs, and other active compounds through the skin, improving the efficiency of PDT in the treatment of cutaneous neoplasms.
authors: Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903, Ribeirão Preto-SP, Brazil.
authors: D M
authors: DM
authors: Ferreira
authors: Y Y
authors: YY
authors: Saga
authors: E
authors: E
authors: Aluicio-Sarduy
authors: A C
authors: AC
authors: Tedesco
mesh_terms: D000622:Aminolevulinic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D048271:Chitosan / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D053672:Electrochemotherapy / Q000379:methods*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D053758:Nanoparticles / Q000008:administration & dosage*; D010778:Photochemotherapy / Q000379:methods*
chemical_list: D000622:Aminolevulinic Acid; D048271:Chitosan