title: Inhibition of α-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia.
abstract: Staphylococcal pneumonia provoked by methicillin-resistant Staphylococcus aureus (MRSA) is a life-threatening infection in which α-toxin is an essential virulence factor. In this study, we investigate the influence of naringenin on α-toxin production and further assess its therapeutic performance in the treatment of staphylococcal pneumonia. Remarkably, the expression of α-toxin was significantly inhibited when the organism was treated with 16 μg/ml of naringenin. When studied in a mouse model of S. aureus pneumonia, naringenin could attenuate the symptoms of lung injury and inflammation in infected mice. These results suggest that naringenin is a promising agent for treatment of S. aureus infection.
authors: Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, PR China.
authors: Yu
authors: Y
authors: Zhang
authors: Jian-Feng
authors: JF
authors: Wang
authors: Jing
authors: J
authors: Dong
authors: Jing-Yuan
authors: JY
authors: Wei
authors: Ya-Nan
authors: YN
authors: Wang
authors: Xiao-Han
authors: XH
authors: Dai
authors: Xin
authors: X
authors: Wang
authors: Ming-Jing
authors: MJ
authors: Luo
authors: Wei
authors: W
authors: Tan
authors: Xu-Ming
authors: XM
authors: Deng
authors: Xiao-di
authors: XD
authors: Niu
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis*; D002460:Cell Line; D032083:Citrus paradisi / Q000737:chemistry; D005260:Female; D044950:Flavanones / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000382:microbiology; D018551:Solanum lycopersicum / Q000737:chemistry; D055624:Methicillin-Resistant Staphylococcus aureus / Q000378:metabolism / Q000472:pathogenicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011023:Pneumonia, Staphylococcal / Q000188:drug therapy* / Q000382:microbiology; D037521:Virulence Factors / Q000096:biosynthesis*
chemical_list: D001427:Bacterial Toxins; D044950:Flavanones; D010936:Plant Extracts; D037521:Virulence Factors; C005273:naringenin