title: Pituitary stem cells: candidates and implications.
abstract: The pituitary is the master endocrine gland of the body. It undergoes many changes after birth, and these changes may be mediated by the differentiation of pituitary stem cells. Stem cells in any tissue source must display (1) pluripotent capacity, (2) capacity for indefinite self-renewal, and (3) a lack of specialization. Unlike neural stem cells identified in the hippocampus and subventricular zone, pituitary stem cells are not associated with one specific cell type. There are many major candidates that are thought to be potential pituitary stem cell sources. This article reviews the evidence for each of the major cell types and discuss the implications of identifying a definitive pituitary stem cell type.
authors: Division of Neurosurgery, Department of Surgery, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada. farshad.nassiri@mail.utoronto.ca
authors: Farshad
authors: F
authors: Nassiri
authors: Michael
authors: M
authors: Cusimano
authors: Jeff A
authors: JA
authors: Zuccato
authors: Safraz
authors: S
authors: Mohammed
authors: Fabio
authors: F
authors: Rotondo
authors: Eva
authors: E
authors: Horvath
authors: Luis V
authors: LV
authors: Syro
authors: Kalman
authors: K
authors: Kovacs
authors: Ricardo V
authors: RV
authors: Lloyd
mesh_terms: D006801:Humans; D010902:Pituitary Gland / Q000166:cytology*; D010903:Pituitary Gland, Anterior / Q000473:pathology; D013234:Stem Cells / Q000166:cytology*