title: Breaking news on fragile sites in cancer.
abstract: Chromosome rearrangements in B lymphocytes can be initiated by AID-associated double strand breaks (DSBs), with others arising by unclear mechanisms. A recent study by Barlow and colleagues in Cell reports on genomic regions, termed early replicating fragile sites, that may explain many AID-independent DSBs and creates a compelling link between replication stress, transcription, and chromosome rearrangements.
authors: Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. glover@umich.edu
authors: Thomas W
authors: TW
authors: Glover
authors: Thomas E
authors: TE
authors: Wilson