title: Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols.
abstract: A fully convergent one-pot two-step synthesis of different chiral 1,2,3-triazole-derived diols in high yields and excellent enantio- and diastereoselectivities has been achieved under very mild conditions in aqueous medium by combining a single alcohol dehydrogenase (ADH) with a Cu-catalysed 'click' reaction.
authors: Dpto. de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo. c/Julián Clavería 8, 33006, Oviedo, Spain. lavanderaivan@uniovi.es vgs@uniovi.es.
authors: Aníbal
authors: A
authors: Cuetos
authors: Dpto. de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo. c/Julián Clavería 8, 33006, Oviedo, Spain. lavanderaivan@uniovi.es vgs@uniovi.es.
authors: Fabricio R
authors: FR
authors: Bisogno
authors: Dpto. de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo. c/Julián Clavería 8, 33006, Oviedo, Spain. lavanderaivan@uniovi.es vgs@uniovi.es.
authors: Iván
authors: I
authors: Lavandera
authors: Dpto. de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo. c/Julián Clavería 8, 33006, Oviedo, Spain. lavanderaivan@uniovi.es vgs@uniovi.es.
authors: Vicente
authors: V
authors: Gotor
mesh_terms: D000426:Alcohol Dehydrogenase / Q000737:chemistry / Q000378:metabolism*; D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000438:Alcohols; D014230:Triazoles; D003300:Copper; D000426:Alcohol Dehydrogenase