title: Variation in antimüllerian hormone concentration during the menstrual cycle may change the clinical classification of the ovarian response.
abstract: OBJECTIVE
  To assess the variability of antimüllerian hormone (AMH) concentrations in women with "adequate ovarian reserve" during unstimulated menstrual cycles and to determine the impact on clinical classifications.
  
  
  METHODS
  Pilot cohort study.
  
  
  METHODS
  Private fertility clinic.
  
  
  METHODS
  Twelve consecutive women (aged 29 to 43 years) referred to a fertility service, with AMH measurements repeated throughout unstimulated cycle, and who had at least one AMH measurement indicating "adequate ovarian reserve."
  
  
  METHODS
  None.
  
  
  METHODS
  AMH concentrations assessed in 82 serum samples from 12 women compared against the published cutoffs for reduced ovarian reserve and for risk of excessive response to ovarian stimulation.
  
  
  RESULTS
  Over half the women (7 of 12) were reclassified as a result of testing AMH concentrations at different phases of the menstrual cycle. Over one-third (4 or 5 of 12) crossed a cutoff for reduced ovarian reserve; 2 of 12 crossed cutoffs predicting hyperstimulation. There was a statistically significant change in AMH concentration according to the day of the cycle, with a negative trend of the median AMH concentration from the follicular to luteal phase. The maximum change in median AMH concentration over cycle was 7.9 pmol/L, and the mean difference between the maximum and minimum AMH was 6.7 pmol/L.
  
  
  CONCLUSIONS
  In this pilot study, the AMH concentration varied during menstrual cycle, and the clinical classification of the ovarian response was altered.
authors: Western Diagnostic Pathology, Myaree, Western Australia, Australia. narelle.hadlow@wdp.com.au
authors: Narelle
authors: N
authors: Hadlow
authors: Katherine
authors: K
authors: Longhurst
authors: Allison
authors: A
authors: McClements
authors: Jay
authors: J
authors: Natalwala
authors: Suzanne J
authors: SJ
authors: Brown
authors: Phillip L
authors: PL
authors: Matson
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood*; D010053:Ovary / Q000378:metabolism*; D010062:Ovulation Induction / Q000145:classification* / Q000592:standards*; D010865:Pilot Projects
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone