title: Intrahepatic lipid, not visceral or muscle fat, is correlated with insulin resistance in older, female rhesus macaques.
abstract: OBJECTIVE
  Little is known of the effect of body composition on glucose metabolism in the aging female non-human primate. These variables in older female Rhesus macaques were studied.
  
  
  METHODS
  Female Rhesus macaques (Macaca mulatta, n = 19, age range 23-30 years) underwent magnetic resonance imaging and (1) H spectroscopy to quantify total abdominal fat, visceral fat (VF), subcutaneous fat (SF) area, extramyocellular lipid (EMCL), intramyocellular lipid (IMCL) and intrahepatic lipid (IHL) content, and DEXA scan for whole body composition. A subgroup (n = 12) underwent a fasting blood draw and intravenous glucose tolerance test.
  
  
  RESULTS
  SF correlated with homeostatic model assessment of insulin resistance (HOMAIR ) and quantitative insulin sensitivity check index (QUICKI), but not after adjustment for fat mass. IHL demonstrated the strongest correlation with HOMAIR , QUICKI and calculated insulin sensitivity index (CSI ), and remained significant after adjustment for fat mass. VF, IMCL, and EMCL did not correlate with any of our measures of insulin sensitivity.
  
  
  CONCLUSIONS
  Despite a greater amount of VF compared to SF, VF was not associated with markers of insulin resistance (IR) in the older female monkey. Instead, IHL is a marker for IR in the fasting and post-prandial state in these animals.
authors: Department of Medicine, Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR, USA.
authors: Michael P
authors: MP
authors: Chu
authors: Bethany J
authors: BJ
authors: Klopfenstein
authors: Christine M
authors: CM
authors: Krisky
authors: Henryk F
authors: HF
authors: Urbanski
authors: William D
authors: WD
authors: Rooney
authors: Steven G
authors: SG
authors: Kohama
authors: Jonathan Q
authors: JQ
authors: Purnell
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity; D000375:Aging; D000818:Animals; D001786:Blood Glucose; D001823:Body Composition; D005234:Fatty Liver / Q000503:physiopathology*; D005260:Female; D005951:Glucose Tolerance Test; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000502:physiology; D008253:Macaca mulatta / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D019518:Postprandial Period; D050151:Subcutaneous Fat / Q000502:physiology
chemical_list: D001786:Blood Glucose