title: SPPS resins impact the PNA-syntheses' improvement.
abstract: The personalized medicine, also documented as "individualized medicine", is an effective and therapeutic approach. It is designed to treat the disease of the individual patient whose precise differential gene expression profile is well known. The trend in the biomedical and biophysical research shows important consequences for the pharmaceutical drug and diagnostics research. It requires a high variability in the design and safety of target-specific pharmacologically active molecules and diagnostic components for imaging of metabolic processes. A key technology which may fulfill the highest demands during synthesis of these individual drugs and diagnostics is the solid phase synthesis which is congenial to automated manufacturing. Additionally the choice of tools like resins and reagents is pivotal to synthesize drugs and diagnostics in high quality and yields. Here we demonstrate the solid phase synthesis effects dependent on the choice of resin and of the deprotection agent.
authors: German Cancer Research Center, Peptide Synthesis Core Facility, INF 280, D-69120 Heidelberg, Germany. r.pipkorn@dkfz.de
authors: Rüdiger
authors: R
authors: Pipkorn
authors: Stephan
authors: S
authors: Rawer
authors: Manfred
authors: M
authors: Wiessler
authors: Waldemar
authors: W
authors: Waldeck
authors: Mario
authors: M
authors: Koch
authors: Hans Hermann
authors: HH
authors: Schrenk
authors: Klaus
authors: K
authors: Braun
mesh_terms: D055808:Drug Discovery; D006801:Humans; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D057285:Precision Medicine; D060327:Solid-Phase Synthesis Techniques; D059467:Transcriptome
chemical_list: D020135:Peptide Nucleic Acids
keywords: peptide nucleic acid (PNA); solid phase peptide synthesis (SPPS).