title: Total zinc absorption from a diet containing either conventional rice or higher-zinc rice does not differ among Bangladeshi preschool children.
abstract: Information is needed on zinc absorption from grain cultivars having higher zinc content. Total absorbed zinc (TAZ) from mixed diets containing high-zinc rice (HZnR), conventional rice (CR), or CR plus zinc fortificant (CR+Zn) was measured. Forty-two nonmalnourished preschool-aged children were enrolled in 1 of 2 groups. Using a crossover design, children in group A (n = 22) received for 1 d each a mixed diet containing 150 g CR or HZnR. Children in group B (n = 20) received HZnR on 1 d and CR+Zn on the other day. Fractional zinc absorption (FZA) was measured during each dietary period by using a dual-isotope tracer ratio technique; TAZ was calculated as the product of zinc intake [total dietary zinc (TDZ)] and FZA. TDZ was 3.83, 4.83, and 6.03 mg/d when the children were fed the CR, HZnR, and CR+Zn-containing diets, respectively. Mean FZA from the CR diet was greater than from the HZnR diet (25.1 vs. 20.1%, P < 0.001), and the mean FZA from the CR+Zn diet (18.8%) was less than from both the CR diet (P < 0.001) and the HZnR diet (P = 0.014). The mean TAZ was 0.96 ± 0.16, 0.97 ± 0.18, and 1.13 ± 0.20 mg/d from the CR, HZnR and CR +Zn diets, respectively. TAZ was not different for the CR and HZnR diets (P = 0.99) but was significantly greater from the CR+Zn diet compared with the other 2 diets (P < 0.001). Rice cultivars with higher zinc and/or lower phytate content are needed to increase TAZ by young children consuming this amount of rice.
authors: International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. mislam@icddrb.org
authors: M Munirul
authors: MM
authors: Islam
authors: Leslie R
authors: LR
authors: Woodhouse
authors: Mohammad Bakhtiar
authors: MB
authors: Hossain
authors: Tahmeed
authors: T
authors: Ahmed
authors: M Nazmul
authors: MN
authors: Huda
authors: Tanveer
authors: T
authors: Ahmed
authors: Janet M
authors: JM
authors: Peerson
authors: Christine
authors: C
authors: Hotz
authors: Kenneth H
authors: KH
authors: Brown
mesh_terms: D001459:Bangladesh; D001682:Biological Availability; D002675:Child, Preschool; D018592:Cross-Over Studies; D004032:Diet; D005260:Female; D005527:Food, Fortified; D006801:Humans; D008297:Male; D012275:Oryza / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D015032:Zinc / Q000008:administration & dosage / Q000172:deficiency / Q000493:pharmacokinetics*; D015033:Zinc Isotopes / Q000652:urine
chemical_list: D015033:Zinc Isotopes; D015032:Zinc