title: Small Indian mongooses and masked palm civets serve as new reservoirs of Bartonella henselae and potential sources of infection for humans.
abstract: The prevalence and genetic properties of Bartonella species were investigated in small Indian mongooses and masked palm civets in Japan. Bartonella henselae, the causative agent of cat-scratch disease (CSD) was isolated from 15.9% (10/63) of the mongooses and 2.0% (1/50) of the masked palm civets, respectively. The bacteraemic level ranged from 3.0 × 10(1) to 8.9 × 10(3) CFU/mL in mongooses and was 7.0 × 10(3) CFU/mL in the masked palm civet. Multispacer typing (MST) analysis based on nine intergenic spacers resulted in the detection of five MST genotypes (MSTs 8, 14, 37, 58 and 59) for the isolates, which grouped in lineage 1 with MST genotypes of isolates from all CSD patients and most of the cats in Japan. It was also found that MST14 from the mongoose strains was the predominant genotype of cat and human strains. This is the first report on the isolation of B. henselae from small Indian mongooses and masked palm civets. The data obtained in the present study suggest that these animals serve as new reservoirs for B. henselae, and may play a role as potential sources of human infection.
authors: Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan.
authors: S
authors: S
authors: Sato
authors: H
authors: H
authors: Kabeya
authors: Y
authors: Y
authors: Shigematsu
authors: H
authors: H
authors: Sentsui
authors: Y
authors: Y
authors: Une
authors: M
authors: M
authors: Minami
authors: K
authors: K
authors: Murata
authors: G
authors: G
authors: Ogura
authors: S
authors: S
authors: Maruyama
mesh_terms: D000818:Animals; D016470:Bacteremia / Q000382:microbiology / Q000662:veterinary; D015373:Bacterial Typing Techniques; D001474:Bartonella Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D018416:Bartonella henselae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D002372:Cat-Scratch Disease / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D002415:Cats; D004269:DNA, Bacterial; D004197:Disease Reservoirs; D005838:Genotype; D008988:Herpestidae / Q000382:microbiology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D010802:Phylogeny; D045949:Viverridae / Q000382:microbiology*
chemical_list: D004269:DNA, Bacterial
keywords: Bartonella henselae; cat-scratch disease; masked palm civet; mongoose; multispacer typing