title: Effect of metformin on ovulation and reproductive outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  To evaluate the effect of MET on ovulation and reproductive outcomes in patients with polycystic ovary syndrome.
  
  
  METHODS
  Meta-analysis of available data from randomized controlled trials that examined the ovulation, pregnancy and live birth rate after the administration of clomiphene citrate (CC) or MET alone or combined.
  
  
  RESULTS
  The ovulation rate was found to be higher in the group treated with MET combined with clomiphene citrate (CC) than only with CC, odds ratio (OR): 1.27, 95 % confidence interval (95 % CI) (1.03-1.56), while the pregnancy and live birth rate showed no significant difference between the two groups, OR: 1.19, 95 % CI (0.99-1.42) and OR: 0.99, 95 % CI (0.84-1.17), respectively. The MET + CC group produced a higher ovulation and pregnancy rate than MET group, OR: 2.10, 95 % CI (1.89-2.34) and OR: 2.08, 95 % CI (1.55-2.80), respectively, while between two groups the live birth rate showed no significant difference, OR: 1.50, 95 % CI (0.75-3.00). The ovulation rate was lower in MET than in CC group, OR: 0.65, 95 % CI (0.43-0.995), while between the two groups the pregnancy and live birth rate showed no significant difference, OR: 0.86, 95 % CI (0.42-1.74) and OR: 0.89, 95 % CI (0.71-1.13).
  
  
  CONCLUSIONS
  The current study indicated that combination of MET and CC could gain advantage over a single administration in the ovulation induction and pregnancy rate.
authors: Institute of Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China. zymsxl@126.com
authors: Xiaoli
authors: X
authors: Sun
authors: Dan
authors: D
authors: Zhang
authors: Wei
authors: W
authors: Zhang
mesh_terms: D002996:Clomiphene / Q000494:pharmacology / Q000627:therapeutic use; D016001:Confidence Intervals; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D050498:Live Birth; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use*; D016017:Odds Ratio; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D016032:Randomized Controlled Trials as Topic
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene; D008687:Metformin