title: Constructions of tetrahydro-γ-carboline skeletons via intramolecular oxidative carbon-carbon bond formation of enamines.
abstract: The synthetically and biologically important 4-methyl and 4-methoxy tetrahydro-γ-carboline compounds were readily synthesized in high yields from an aryl amine and a 5-amino-3-oxopentanoate derivative through a series of reactions of enamination, oxidative annulation, deprotection/lactamization and the final reduction reaction of the carbonyl group. The underpinning strategy involves the oxidative C(sp(2))-C(sp(2)) bond formation realized by either Pd(OAc)2/Cu(OAc)2 or a hypervalent iodine reagent.
authors: Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, PR China.
authors: Jinglei
authors: J
authors: Lv
authors: Ji
authors: J
authors: Li
authors: Daisy
authors: D
authors: Zhang-Negrerie
authors: Siyun
authors: S
authors: Shang
authors: Qingzhi
authors: Q
authors: Gao
authors: Yunfei
authors: Y
authors: Du
authors: Kang
authors: K
authors: Zhao
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002243:Carbolines / Q000138:chemical synthesis / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000588:Amines; D002243:Carbolines; D002244:Carbon