title: Construction of robust enzyme nanocapsules for effective organophosphate decontamination, detoxification, and protection.
abstract: Nanocapsules of organophosphorous hydrolase with enhanced enzyme activity and stability are prepared via in situ polymerization, providing a novel class of nanoparticles for the decontamination and detoxification of organophosphates such as chemical warfare agents and pesticides. Using the nanocapsules as building blocks, bioactive nanocomposites are also fabricated, enabling their use for organophosphate protection.
authors: College of Material Science and Engineering, Donghua University, Shanghai 201620, PR China.
authors: Wei
authors: W
authors: Wei
authors: Juanjuan
authors: J
authors: Du
authors: Jie
authors: J
authors: Li
authors: Ming
authors: M
authors: Yan
authors: Qi
authors: Q
authors: Zhu
authors: Xin
authors: X
authors: Jin
authors: Xinyuan
authors: X
authors: Zhu
authors: Zuming
authors: Z
authors: Hu
authors: Yi
authors: Y
authors: Tang
authors: Yunfeng
authors: Y
authors: Lu
mesh_terms: D016475:3T3 Cells; D000818:Animals; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D002619:Chemical Warfare Agents / Q000737:chemistry / Q000378:metabolism; D004800:Enzymes, Immobilized / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry*; D010755:Organophosphates / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D010261:Paraoxon / Q000378:metabolism / Q000633:toxicity; D010575:Pesticides / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry
chemical_list: D002619:Chemical Warfare Agents; D004800:Enzymes, Immobilized; D053769:Nanocapsules; D010755:Organophosphates; D010575:Pesticides; D011108:Polymers; D043303:Aryldialkylphosphatase; D010261:Paraoxon