title: Midbrain-derived neurotrophins support survival of immature striatal projection neurons.
abstract: Neuronal death occurs at several stages during embryogenesis and early postnatal development; however, it is unknown how the survival of immature neurons at their origin is regulated before these cells migrate to their final destination. Striatal projection neurons, known as medium-sized spiny neurons (MSNs), in both the direct and indirect pathways are generated in the lateral ganglionic eminence (LGE). Here we report that brain-derived neurotrophic factor and neurotrophin-3 are anterogradely transported from midbrain dopaminergic neurons and support the survival of immature MSNs of the indirect and direct pathways, respectively, in the developing mouse striatum and LGE. These results reveal a novel mode of neurotrophic action in the nervous system by linking neurotrophins to the survival of immature neurons at their origin, while also suggesting that innervating neurons may control the size of their targeting neuronal population in the brain.
authors: Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA.
authors: Maryna
authors: M
authors: Baydyuk
authors: Yuxiang
authors: Y
authors: Xie
authors: Lino
authors: L
authors: Tessarollo
authors: Baoji
authors: B
authors: Xu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology*; D003342:Corpus Striatum / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D059290:Dopaminergic Neurons / Q000378:metabolism / Q000502:physiology; D005260:Female; D008297:Male; D008636:Mesencephalon / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009414:Nerve Growth Factors / Q000502:physiology*; D009474:Neurons / Q000145:classification / Q000502:physiology*; D020933:Neurotrophin 3 / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D020933:Neurotrophin 3