title: Is rapid effect of thyroxine on GABAergic IPSCs purely postsynaptic?
abstract: BACKGROUND
  Thyroid hormones (THs) are well known for their genomic effects but recently several studies revealed their actions as rapid modulators of membrane receptors. In particular, fast thyroxine effect on GABA(A) receptors have been reported. We addressed question whether presynaptic mechanisms can be also involved in modulation of GABAergic transmission by thyroxine.
  
  
  METHODS
  Using patch-clamp technique we examined fast effects of thyroxine (2 μM) on evoked GABAergic postsynaptic currents.
  
  
  RESULTS
  We found that in addition to the inhibitory effect on IPSC amplitude, thyroxine changed IPSC coefficient of variation (CV).
  
  
  CONCLUSIONS
  This result suggests involvement of a presynaptic mechanism in thyroxine effect on GABAergic transmission.
authors: International Center of Molecular Physiology, Bogomoletz 4, 01024 Kiev, Ukraine. maksim@biph.kiev.ua
authors: Maksim
authors: M
authors: Storozhuk
authors: Svetlana
authors: S
authors: Ivanova
authors: Lyudmila
authors: L
authors: Nikolaenko
authors: Oleg
authors: O
authors: Krishtal
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects*; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid; D013974:Thyroxine