title: Extended-spectrum β-lactamase CTX-M-15-producing Klebsiella pneumoniae of sequence type ST274 in companion animals.
abstract: Screening of extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacteria in companion animals living in the Paris area in France identified a high rate of CTX-M-15-producing Klebsiella pneumoniae. Those isolates were recovered during the 2010-2011 period from both infections and asymptomatic colonizations. Sequence typing revealed that most of these isolates belonged to sequence type ST274. Interestingly, the bla(CTX-M-15) gene was located on a specific and novel plasmid scaffold. These findings highlight that companion animals may be reservoirs for CTX-M-15-producing K. pneumoniae evolving separately from the human reservoir of CTX-M-15 producers.
authors: Service de Bactériologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, Le Kremlin-Bicêtre, France.
authors: Laurent
authors: L
authors: Poirel
authors: Patrice
authors: P
authors: Nordmann
authors: Sébastien
authors: S
authors: Ducroz
authors: Henri-Jean
authors: HJ
authors: Boulouis
authors: Pascal
authors: P
authors: Arné
authors: Yves
authors: Y
authors: Millemann
mesh_terms: D000818:Animals; D015373:Bacterial Typing Techniques; D002415:Cats; D004197:Disease Reservoirs / Q000382:microbiology / Q000662:veterinary*; D004285:Dogs; D005602:France / Q000453:epidemiology; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D007711:Klebsiella pneumoniae / Q000235:genetics* / Q000302:isolation & purification; D057805:Pets / Q000382:microbiology*; D010957:Plasmids; D034561:Sheep, Domestic; D001618:beta-Lactamases / Q000235:genetics* / Q000302:isolation & purification
chemical_list: C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases