title: High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor.
abstract: A highly selective and sensitive near-infrared (NIR) fluorescence probe (Cy-NO2) for imaging nitroreductase was developed and was successfully applied to investigating the relationship between epithelial-mesenchymal transitions (EMTs) in tumour progression and intracellular hypoxic level.
authors: College of Chemistry, Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China.
authors: Kehua
authors: K
authors: Xu
authors: Feng
authors: F
authors: Wang
authors: Xiaohong
authors: X
authors: Pan
authors: Renpu
authors: R
authors: Liu
authors: Jing
authors: J
authors: Ma
authors: Fanpeng
authors: F
authors: Kong
authors: Bo
authors: B
authors: Tang
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry; D002232:Carbocyanines / Q000737:chemistry; D015687:Cell Hypoxia; D002470:Cell Survival / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000633:toxicity; D056945:Hep G2 Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D008862:Microsomes, Liver / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology; D009585:Nitrogen Dioxide / Q000737:chemistry; D009601:Nitroreductases / Q000737:chemistry / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared
chemical_list: D052160:Benzothiazoles; D002232:Carbocyanines; D005456:Fluorescent Dyes; C011204:cyanine dye 7; D009601:Nitroreductases; D009585:Nitrogen Dioxide