title: Lifestyle intervention reduces body weight and improves cardiometabolic risk factors in worksites.
abstract: BACKGROUND
  Worksites are potentially effective locations for obesity control because they provide opportunities for group intervention and social support. Studies are needed to identify effective interventions in these settings.
  
  
  OBJECTIVE
  We examined the effects of a multicomponent lifestyle intervention on weight loss and prevention of regain in 4 worksites (2 intervention and 2 control sites).
  
  
  METHODS
  Overweight and obese employees (n = 133) enrolled in this pilot worksite-randomized controlled trial with a 0-6-mo weight-loss phase and a 6-12-mo structured weight-maintenance phase. The intervention combined recommendations to consume a reduced-energy, low-glycemic load, high-fiber diet with behavioral change education. Outcome measurements included changes in body weight and cardiometabolic risk factors.
  
  
  RESULTS
  The mean ± SEM weight loss was substantial in intervention participants, whereas control subjects gained weight (-8.0 ± 0.7 compared with +0.9 ± 0.5 kg, respectively; P < 0.001), and 89% of participants completed the weight-loss phase. Intervention effects were not significant at the 0.05 level but would have been at the 0.10 level (P = 0.08) in a mixed model in which the worksite nested within group was a random factor. There were also significant improvements in cardiometabolic risk factors in intervention compared with control subjects regarding fasting total cholesterol, glucose, systolic blood pressure, and diastolic blood pressure (P ≤ 0.02 for each). No significant weight regain was observed in participants who enrolled in the structured weight-maintenance program (0.5 ± 0.7 kg; P = 0.65), and overweight and obese employees in intervention worksites who were not enrolled in the weight-loss program lost weight compared with subjects in control worksites (-1.3 ± 0.5 compared with +0.7 ± 0.2 kg, respectively; P = 0.02).
  
  
  CONCLUSIONS
  Worksites can be effective for achieving clinically important reductions in body weight and improved cardiometabolic risk factors. This trial was registered at clinicaltrials.gov as NCT01470222.
authors: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
authors: Taylor C
authors: TC
authors: Salinardi
authors: Payal
authors: P
authors: Batra
authors: Susan B
authors: SB
authors: Roberts
authors: Lorien E
authors: LE
authors: Urban
authors: Lisa M
authors: LM
authors: Robinson
authors: Anastassios G
authors: AG
authors: Pittas
authors: Alice H
authors: AH
authors: Lichtenstein
authors: Thilo
authors: T
authors: Deckersbach
authors: Edward
authors: E
authors: Saltzman
authors: Sai Krupa
authors: SK
authors: Das
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D004038:Diet, Reducing; D004043:Dietary Fiber / Q000008:administration & dosage; D005260:Female; D038321:Glycemic Index; D015438:Health Behavior; D006266:Health Education; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy / Q000628:therapy*; D009786:Occupational Health Services; D017063:Outcome Assessment, Health Care; D010865:Pilot Projects; D012307:Risk Factors; D015430:Weight Gain; D015431:Weight Loss; D017132:Workplace
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D002784:Cholesterol