title: Clinic-epidemiologic study of human infection by Granada virus, a new phlebovirus within the sandfly fever Naples serocomplex.
abstract: Granada virus (GRV), a new phlebovirus within the Naples serocomplex, has been recently described in phlebotomine sandflies from Spain. The presence of anti-GRV immunoglobulin G (IgG) antibodies was investigated by indirect fluorescence assay (IFA) and neutralization test (NT) in 920 serum samples from the Granada population. By IFA, an overall GRV seroprevalence of 15.8% (N = 145) was observed, significantly increasing up to 65 years. NT was positive in 18% of anti-GRV IFA-positive samples. IgG antibodies against Toscana virus (TOSV), a hyperendemic phlebovirus within Granada province, were detected in 40% of anti-GRV-positive cases. Anti-GRV IgM antibodies were detected in 36 (6.6%) of 547 acute-phase serum samples from individuals with febrile illness, exanthema, and/or acute respiratory infection. All positives were anti-TOSV IgM-negative. GRV may infect humans, with most cases being asymptomatic. The codetection of anti-GRV and anti-TOSV IgG antibodies could be attributable to cross-reactivity or exposure to the same transmission vector.
authors: Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain. josem.navarro.sspa@juntadeandalucia.es
authors: José María
authors: JM
authors: Navarro-Marí
authors: Cristina
authors: C
authors: Gómez-Camarasa
authors: Mercedes
authors: M
authors: Pérez-Ruiz
authors: Sara
authors: S
authors: Sanbonmatsu-Gámez
authors: Irene
authors: I
authors: Pedrosa-Corral
authors: María
authors: M
authors: Jiménez-Valera
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D003429:Cross Reactions; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008875:Middle Aged; D010217:Phlebotomus Fever / Q000453:epidemiology* / Q000503:physiopathology* / Q000821:virology; D016856:Phlebovirus / Q000276:immunology*; D011576:Psychodidae / Q000821:virology; D029301:Sandfly fever Naples virus / Q000276:immunology; D016036:Seroepidemiologic Studies; D013030:Spain / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M