title: A randomized controlled trial to evaluate the relative efficacy of the addition of a psycho-social intervention to standard-of-care services in reducing attrition and improving attendance among first-time users of methadone maintenance treatment in China.
abstract: Although methadone maintenance treatment (MMT) is an important means of HIV control, MMT clinics commonly have high attrition rates. The randomized controlled trial investigated the relative efficacy of adding a psycho-social intervention to the standard-of-care MMT in reducing attrition and non-attendance among first-time newly admitted MMT users in China (n = 288). Social workers implemented this three-phase intervention that was based on a behavioral maintenance theory. It also involved participants' family members and rectified some MMT-related misconceptions. As compared to the control group, the intervention group showed significantly lower likelihood of attrition (HR = 0.55, 95% confidence interval 0.39-0.80), lower estimated probability of attrition at Month 12 (0.35 vs. 0.55), and higher median number of days of attendance (Month 6: 147 vs. 91 days, p < 0.001; end-date: 225 vs. 142 days, p < 0.001). Further psycho-social services and translational research are warranted.
authors: 309, School of Public Health, Sun Yat-sen University, No. 74, Zhongshan Road II, Guangzhou 510080, China. gujing0828@hotmail.com
authors: Jing
authors: J
authors: Gu
authors: Joseph T F
authors: JT
authors: Lau
authors: Huifang
authors: H
authors: Xu
authors: Ying
authors: Y
authors: Zhong
authors: Yuantao
authors: Y
authors: Hao
authors: Yuteng
authors: Y
authors: Zhao
authors: Lirui
authors: L
authors: Fan
authors: Wenhua
authors: W
authors: Ling
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D015658:HIV Infections / Q000517:prevention & control; D006556:Heroin Dependence / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008691:Methadone / Q000627:therapeutic use*; D009294:Narcotics / Q000627:therapeutic use*; D058850:Opiate Substitution Treatment / Q000379:methods*; D010353:Patient Education as Topic / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D009294:Narcotics; D008691:Methadone