title: Biodegradable IPN hydrogel beads of pectin and grafted alginate for controlled delivery of diclofenac sodium.
abstract: A novel diclofenac sodium (DS) loaded interpenetrating polymer network (IPN) beads of pectin and hydrolyzed polyacrylamide-graft-sodium alginate (PAAm-g-SA) was developed through ionotropic gelation and covalent cross-linking. The graft copolymer was synthesized by free radical polymerization under the nitrogen atmosphere followed by alkaline hydrolysis. The grafting, alkaline hydrolysis, and characterization of beads were confirmed by Fourier transforms infrared spectroscopy. The crystalline structure of drug after encapsulation into IPN beads were evaluated by differential scanning colorimetry and X-ray diffraction analyses. DS encapsulation was up to 96.45 %. The effect of hydrolyzed graft copolymer/pectin ratios and glutaraldehyde concentration on drug release in acidic and phosphate buffer solutions were investigated. The release of drug was significantly increased with increase of pH. The release of drug depends on the extent of cross-linking. The results indicated that IPN beads of hydrolyzed PAAm-g-SA and pectin could be used for sustained release of DS.
authors: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai 491024, India. tapan_ju01@rediffmail.com
authors: Tapan Kumar
authors: TK
authors: Giri
authors: Deepa
authors: D
authors: Thakur
authors: Amit
authors: A
authors: Alexander
authors: Ajazuddin
authors: Hemant
authors: H
authors: Badwaik
authors: Minaketan
authors: M
authors: Tripathy
authors: Dulal Krishna
authors: DK
authors: Tripathi
mesh_terms: D020341:Absorbable Implants; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry; D004008:Diclofenac / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000295:instrumentation; D016503:Drug Delivery Systems; D004343:Drug Implants / Q000138:chemical synthesis / Q000737:chemistry*; D005260:Female; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry; D008863:Microspheres; D010368:Pectins / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000464:Alginates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D004008:Diclofenac; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010368:Pectins