title: [Magnetic nanoparticles as tools for cell therapy].
abstract: Labelling living cells with magnetic nanoparticles creates opportunities for numerous           biomedical applications such as Magnetic Resonance Imaging (MRI) cell tracking, cell           manipulation, cell patterning for tissue engineering and magnetically-assisted cell           delivery. The unique advantage of magnetic-based methods is to activate or monitor cell           behavior by a remote stimulus, the magnetic field. Cell labelling methods using           superparamagnetic nanoparticles have been widely developed, showing no adverse effect on           cell proliferation and functionalities while conferring magnetic properties to various           cell types. This paper first describes how cells can become responsive to magnetic field           by safely internalizing magnetic nanoparticles. We next show how magnetic cells can be           detected by MRI, giving the opportunity for non-invasive in vivo           monitoring of cell migration. We exemplify the fact that MRI cell tracking has become a           method of choice to follow the fate of administrated cells in cell therapy assay, whether           the cells are grafted locally or administrated in the circulation. Finally we give           different examples of magnetic manipulation of cells and their applications to           regenerative medicine. Magnetic cell manipulation are forecasted to be more and more           developed, in order to improve tissue engineering technique and assist cell-based           therapies. Owing to the clinical approval of iron-oxide nanoparticles as MRI contrast           agent, there is no major obstacle in the translation to human clinics of the magnetic           methods summarized in this paper.
authors: Laboratoire Matière et Systèmes Complexes, CNRS – Université Paris Diderot, 75205 Paris Cedex 13, France. claire.wilhelm@univ-paris-diderot.fr
authors: Claire
authors: C
authors: Wilhelm
authors: Florence
authors: F
authors: Gazeau
mesh_terms: D002465:Cell Movement; D017690:Cell Transplantation / Q000379:methods*; D005290:Ferric Compounds; D006801:Humans; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D053758:Nanoparticles; D044968:Regenerative Medicine / Q000379:methods; D023822:Tissue Engineering / Q000379:methods
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide