title: Severe gastrointestinal mucositis following high dose melphalan therapy for multiple myeloma.
abstract: Mucositis is a known complication following use of chemotherapy, but fatal mucositis is unusual and management of such cases may be challenging. Pathologically there is denudation of mucosa of gastrointestinal tract. Severe cases can develop ileus and even perforation of bowel wall. We report here a case of multiple myeloma who developed World Health Organization grade 4 gut mucositis following the use of high dose melphalan with the expulsion of "intestine-like" material.
authors: Sanjeev Kumar
authors: SK
authors: Sharma
authors: Anil
authors: A
authors: Handoo
authors: Dharma
authors: D
authors: Choudhary
authors: Gaurav
authors: G
authors: Dhamija
authors: Nitin
authors: N
authors: Gupta
mesh_terms: D017809:Fatal Outcome; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D052016:Mucositis / Q000139:chemically induced* / Q000473:pathology; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000601:surgery; D019653:Myeloablative Agonists / Q000008:administration & dosage / Q000009:adverse effects*; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning / Q000009:adverse effects* / Q000379:methods
chemical_list: D019653:Myeloablative Agonists; D008558:Melphalan
keywords: Chemotherapy; Gastrointestinal mucositis