title: Altered activities of antioxidant enzymes in patients with metabolic syndrome.
abstract: OBJECTIVE
  In the pathogenesis of the metabolic syndrome (MetS), an increase of oxidative stress could play an important role which is closely linked with insulin resistance, endothelial dysfunction, and chronic inflammation. The aim of our study was to assess several parameters of the antioxidant status in MetS.
  
  
  METHODS
  40 subjects with MetS and 40 age- and sex-matched volunteers without MetS were examined for activities of superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase 1 (GPX1), glutathione reductase (GR), paraoxonase1 (PON1), concentrations of reduced glutathione (GSH), and conjugated dienes in low-density lipoprotein (CD-LDL).
  
  
  RESULTS
  Subjects with MetS had higher activities of CuZnSOD (p < 0.05) and GR (p < 0.001), higher concentrations of CD-LDL (p < 0.001), lower activities of CAT (p < 0.05) and PON1 (p < 0.05), and lower concentrations of GSH (p < 0.05), as compared with controls. Activity of GPX1 was not significantly changed.
  
  
  CONCLUSIONS
  Our results implicated an increased oxidative stress in MetS and a decreased antioxidative defense that correlated with some laboratory (triglycerides, high-density lipoprotein cholesterol (HDL-C)) and clinical (waist circumference, blood pressure) components of MetS.
authors: 4th Department of Internal Medicine, First Faculty of Medicine, Charles University, and General Teaching Hospital, Prague, Czech Republic. vavrova3@seznam.cz
authors: Lucie
authors: L
authors: Vávrová
authors: Jana
authors: J
authors: Kodydková
authors: Miroslav
authors: M
authors: Zeman
authors: Magdaléna
authors: M
authors: Dušejovská
authors: Jaroslav
authors: J
authors: Macášek
authors: Barbora
authors: B
authors: Staňková
authors: Eva
authors: E
authors: Tvrzická
authors: Aleš
authors: A
authors: Zák
mesh_terms: D000975:Antioxidants / Q000032:analysis*; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D004798:Enzymes / Q000097:blood*; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D000094765:Glutathione Peroxidase GPX1
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D004798:Enzymes; D008077:Lipoproteins, LDL; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D005978:Glutathione; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human