title: Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease.
abstract: Current research including the basic biology of Alzheimer's disease (AD) provides a foundation to explore whether our current state of knowledge is sufficient to initiate prevention studies and allow us to believe prevention of AD is possible. Current research and recently revised criteria for the diagnosis of AD by the National Institutes on Aging and the Alzheimer's Association suggest a continuum of disease from preclinical asymptomatic to symptomatic Alzheimer's dementia. In light of these revised criteria, the possibility of secondary prevention and even primary prevention is under discussion. The Alzheimer's Association Research Roundtable convened a meeting to discuss the rationale and feasibility of conducting secondary prevention trials in AD.
authors: Alzheimer's Association, Chicago, IL, USA. maria.carrillo@alz.org
authors: Maria C
authors: MC
authors: Carrillo
authors: H Robert
authors: HR
authors: Brashear
authors: Veronika
authors: V
authors: Logovinsky
authors: J Michael
authors: JM
authors: Ryan
authors: Howard H
authors: HH
authors: Feldman
authors: Eric R
authors: ER
authors: Siemers
authors: Susan
authors: S
authors: Abushakra
authors: Dean M
authors: DM
authors: Hartley
authors: Ronald C
authors: RC
authors: Petersen
authors: Ara S
authors: AS
authors: Khachaturian
authors: Reisa A
authors: RA
authors: Sperling
mesh_terms: D000544:Alzheimer Disease / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D006801:Humans; D055502:Secondary Prevention / Q000379:methods*