title: Total synthesis of antibiotics: recent achievements, limitations, and perspectives.
abstract: Several recently accomplished total syntheses of antibiotic natural products were summarized in this review in order to present current trends in this area of research. Compounds from different substance classes, including polyketide, depsipeptide, polyketide-polypeptide hybrid, and saccharide, were chosen to demonstrate the advancement in both chemical methodology and corresponding synthetic strategy.
authors: Helmholtz Zentrum für Infektionsforschung, Braunschweig, Germany. Evgeny.Prusov@helmholtz-hzi.de
authors: Evgeny V
authors: EV
authors: Prusov
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001419:Bacteria / Q000235:genetics* / Q000378:metabolism*; D053898:Biosynthetic Pathways / Q000235:genetics*; D001709:Biotechnology / Q000379:methods*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents