title: Complex formation, thermal behavior and stability competition between Cu(II) ion and Cu(0) nanoparticles with some new azo dyes. Antioxidant and in vitro cytotoxic activity.
abstract: Four triazole and thiadiazole-based azo chromophores namely [(E)-4-((1H-1,2,4-triazol-3-yl)diazenyl)benzene-1,3-diol.(HL(1)), (E)-4-((5-(methylthio)-1H-1,2,4-triazol-3-yl)diazenyl)benzene-1,3-diol.(HL(2)), (E)-4-((1,3,4-thiadiazol-2-yl)diazenyl)benzene-1,3-diol.(HL(3)) and (E)-4-((5-mercapto-1,3,4-thiadiazol-2-yl)diazenyl)benzene-1,3-diol.(HL(4))] were synthesized and characterized by elemental analyses, IR, UV-Vis as well as mass spectroscopy. Cu(II) complexes of the investigated azo dyes have been synthesized and characterized by elemental analyses, IR, electronic and ESR spectra, magnetic susceptibility and thermogravimetric analyses. The bond lengths and bond angles have been calculated to confirm the geometry of the ligands and their Cu(II) complexes. The mode of interaction of the azodyes to copper nanoparticles was described as coordination mode of charged dye molecules on the colloidal Cu(0) surface through anchoring OH(-) group. The apparent association constants of the colloidal copper nanoparticles azodye complexes in solution were evaluated using the spectral method and compared with the formation constant of the Cu(II) azo complexes. The antitumor and antioxidant activities of the synthesized azo dyes and their Cu(II) azo complexes have been evaluated.
authors: Chemistry Department, Faculty of Science, Tanta University, 31527 Tanta, Egypt. abuelazm@yahoo.com
authors: M
authors: M
authors: Gaber
authors: Y S
authors: YS
authors: El-Sayed
authors: K Y
authors: KY
authors: El-Baradie
authors: R M
authors: RM
authors: Fahmy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001391:Azo Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D052160:Benzothiazoles / Q000737:chemistry; D002277:Carcinoma / Q000188:drug therapy; D004396:Coloring Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D013057:Spectrum Analysis; D013451:Sulfonic Acids / Q000737:chemistry; D013830:Thiadiazoles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D014230:Triazoles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001391:Azo Compounds; D052160:Benzothiazoles; D004396:Coloring Agents; D056831:Coordination Complexes; D013451:Sulfonic Acids; D013830:Thiadiazoles; D014230:Triazoles; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D003300:Copper