title: Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides.
abstract: A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed. Traditional (12)C/(1)H and heavy stable isotope (13)C/(2)H-labeled chelator-amino acid conjugates are used as chelating agents to quantify contaminating transition metals, allowing for determination of effective specific activity of radio-metals.
authors: Department of Radiology, University of Pittsburgh, 100 Technology Drive, Suite 452F, Pittsburgh, PA 15219, USA.
authors: Dexing
authors: D
authors: Zeng
authors: Carolyn J
authors: CJ
authors: Anderson
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002247:Carbon Isotopes; D002614:Chelating Agents / Q000737:chemistry; D002853:Chromatography, Liquid; D003903:Deuterium; D013058:Mass Spectrometry; D015394:Molecular Structure; D028561:Transition Elements / Q000032:analysis*
chemical_list: D000596:Amino Acids; D002247:Carbon Isotopes; D002614:Chelating Agents; D028561:Transition Elements; D003903:Deuterium