title: Photodynamic detection and management of intraperitoneal spreading of primary peritoneal papillary serous carcinoma in a man: report of a case.
abstract: As a peritoneal surface malignancy, primary peritoneal papillary serous carcinoma (PPPSC) almost always occurs in women. Our search of the literature found only two previous case reports of men with PPPSC, both with very short survival. We report the case of a 63-year-old man with PPPSC, treated effectively with cytoreductive surgery and docetaxel-based hyperthermic intraperitoneal chemotherapy following six cycles of docetaxel-based laparoscopic neoadjuvant intraperitoneal and cisplatin-based systemic chemotherapy. Furthermore, we detected intraoperative intraperitoneal spreading of the tumor after the oral administration of 5-amino levulinic acid (5-ALA). The patient remains in good health without ascites 18 months after his diagnosis. Thus, primary peritoneal papillary serous carcinoma should be managed by intraperitoneal chemotherapy combined with peritonectomy procedures. Moreover, the intraoperative detection of the intraperitoneal spreading of the tumor after administering oral 5-ALA shows that this is an exciting and promising diagnostic technique, which needs to be confirmed by further studies.
authors: NPO Organization to support Peritoneal Dissemination Treatment, 1-26, Harukimotomachi, Kishiwada City, Osaka, 596-0032, Japan, drecanbay@gmail.com.
authors: Emel
authors: E
authors: Canbay
authors: Haruaki
authors: H
authors: Ishibashi
authors: Shouzou
authors: S
authors: Sako
authors: Toshiyuki
authors: T
authors: Kitai
authors: Eisei
authors: E
authors: Nishino
authors: Masamitsu
authors: M
authors: Hirano
authors: Akiyoshi
authors: A
authors: Mizumoto
authors: Yoshio
authors: Y
authors: Endo
authors: Shun-Ichiro
authors: S
authors: Ogura
authors: Yutaka
authors: Y
authors: Yonemura
mesh_terms: D000284:Administration, Oral; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000378:metabolism*; D003131:Combined Modality Therapy; D018283:Cystadenocarcinoma, Papillary / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D018284:Cystadenocarcinoma, Serous / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010537:Peritoneum / Q000473:pathology*; D055668:Photochemical Processes; D017319:Photosensitizing Agents; D011524:Protoporphyrins
chemical_list: D017319:Photosensitizing Agents; D011524:Protoporphyrins; D000622:Aminolevulinic Acid; C028025:protoporphyrin IX