title: Cure of relapsing nephrosis by an allogeneic marrow graft for chronic myelogenous leukemia.
abstract: BACKGROUND
  Minimal-change nephrotic syndrome has recently been attributed to an immature, dysfunctional T-cell population.
  
  
  METHODS
  A woman, now 23 years old, developed nephrotic syndrome when she was 6 years old. Despite treatment with steroids and immunosuppressants such as cyclosporine, mizoribine, mycophenolate mofetil, and tacrolimus, the patient relapsed 14 times. At the age of 19 years, she developed chronic myelogenous leukemia, against which imatinib achieved cytogenetic remission. The patient received an allogeneic bone marrow graft transplantation from an unrelated marrow bank donor, with an uncomplicated recovery and molecular genetic remission. Immunosuppressants were withdrawn within 6 months. The patient is now without drug treatment. Complete remission of nephrotic syndrome has also been maintained for over 4 years without any drug administration.
  
  
  CONCLUSIONS
  The patient's course supports suggestions that immunological dysfunction in nephrosis is associated with abnormality of immature, relatively unclassified T cells (CD34(+)) representing hematopoietic stem cells, as opposed to mature T cells (CD34(-)).
authors: Department of Pediatrics, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama 589-8511, Japan.
authors: Keisuke
authors: K
authors: Sugimoto
authors: Naoki
authors: N
authors: Sakata
authors: Shinsuke
authors: S
authors: Fujita
authors: Tomoki
authors: T
authors: Miyazawa
authors: Hitomi
authors: H
authors: Nishi
authors: Tsukasa
authors: T
authors: Takemura
authors: Mitsuru
authors: M
authors: Okada
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D009404:Nephrotic Syndrome / Q000276:immunology / Q000628:therapy*; D012008:Recurrence; D014184:Transplantation, Homologous; D055815:Young Adult