title: The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.
abstract: Dendritic cells (DCs) are critical in immune responses, linking innate and adaptive immunity. We found here that DC-specific deletion of the transcription factor STAT5 was not critical for development but was required for T helper type 2 (TH2), but not TH1, allergic responses in both the skin and lungs. Loss of STAT5 in DCs led to the inability to respond to thymic stromal lymphopoietin (TSLP). STAT5 was required for TSLP-dependent DC activation, including upregulation of the expression of costimulatory molecules and chemokine production. Furthermore, TH2 responses in mice with DC-specific loss of STAT5 resembled those seen in mice deficient in the receptor for TSLP. Our results show that the TSLP-STAT5 axis in DCs is a critical component for the promotion of type 2 immunity at barrier surfaces.
authors: Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA.
authors: Bryan D
authors: BD
authors: Bell
authors: Masayuki
authors: M
authors: Kitajima
authors: Ryan P
authors: RP
authors: Larson
authors: Thomas A
authors: TA
authors: Stoklasek
authors: Kristen
authors: K
authors: Dang
authors: Kazuhito
authors: K
authors: Sakamoto
authors: Kay-Uwe
authors: KU
authors: Wagner
authors: Daniel H
authors: DH
authors: Kaplan
authors: Boris
authors: B
authors: Reizis
authors: Lothar
authors: L
authors: Hennighausen
authors: Steven F
authors: SF
authors: Ziegler
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D003877:Dermatitis, Contact / Q000276:immunology / Q000378:metabolism; D020405:Dermis / Q000276:immunology / Q000378:metabolism; D005260:Female; D006706:Homeostasis / Q000276:immunology; D053612:Janus Kinases / Q000378:metabolism; D008168:Lung / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D050799:STAT5 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D050799:STAT5 Transcription Factor; D053612:Janus Kinases; D000094632:Thymic Stromal Lymphopoietin; C000721967:TSLP protein, mouse