title: Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel .
abstract: An investigation begun in 1979 directed at the Republic of Palau marine sponge Agelas axifera Hentschel for cancer cell growth inhibitory constituents subsequently led to the isolation of three new pyrimidine diterpenes designated axistatins 1 (1), 2 (2), and 3 (3), together with the previously reported formamides 4, 5, and agelasine F (6). The structures were elucidated by analysis of 2D-NMR spectra and by HRMS. All of the isolated compounds were found to be moderate inhibitors of cancer cell growth. Axistatins 1-3 (1-3), formamide 4, and agelasine F (6) also exhibited antimicrobial activity.
authors: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, P.O. Box 871604, Tempe, Arizona 85287-1604, USA. bpettit@asu.edu
authors: George R
authors: GR
authors: Pettit
authors: Yuping
authors: Y
authors: Tang
authors: Qingwen
authors: Q
authors: Zhang
authors: Gregory T
authors: GT
authors: Bourne
authors: Christoph A
authors: CA
authors: Arm
authors: John E
authors: JE
authors: Leet
authors: John C
authors: JC
authors: Knight
authors: Robin K
authors: RK
authors: Pettit
authors: Jean-Charles
authors: JC
authors: Chapuis
authors: Dennis L
authors: DL
authors: Doubek
authors: Franklin J
authors: FJ
authors: Ward
authors: Christine
authors: C
authors: Weber
authors: John N A
authors: JN
authors: Hooper
mesh_terms: D047230:Agelas / Q000737:chemistry*; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019029:Palau; D011687:Purines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D004224:Diterpenes; D006146:Guanidines; D011687:Purines; D011743:Pyrimidines; C412407:agelasine F; C581273:axistatin 1; C581274:axistatin 2; C581275:axistatin 3