title: Serologic evidence of Crimean-Congo hemorrhagic fever virus infection in Hungary.
abstract: Crimean-Congo hemorrhagic fever virus (CCHFV) is a typical tick-borne pathogen that causes an increasing number of severe infections in many parts of Africa, Asia, the Middle East, and the Balkans, as well as in some other parts of Europe. The virus is transmitted primarily by Hyalomma spp., and the spectrum of natural hosts for CCHFV is broad, including wild and domestic animals. Although, the presence of CCHFV was hypothesized in Hungary, no significant research activity has been carried out in the past 30 years. In the present study, we provide serological evidence of CCHFV infection in Lepus europeus using newly developed antibody detection assays. Of 198 samples, 12 (6%) were positive for immunoglobulin G antibody against CCHFV, with 2 independent detection assays. This observation indicates a need for a large-scale surveillance to estimate the potential public health risk of CCHFV in Hungary.
authors: János Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.
authors: Viktória
authors: V
authors: Németh
authors: Miklós
authors: M
authors: Oldal
authors: László
authors: L
authors: Egyed
authors: Miklós
authors: M
authors: Gyuranecz
authors: Károly
authors: K
authors: Erdélyi
authors: Krisztián
authors: K
authors: Kvell
authors: Nikolay
authors: N
authors: Kalvatchev
authors: Herve
authors: H
authors: Zeller
authors: Krisztián
authors: K
authors: Bányai
authors: Ferenc
authors: F
authors: Jakab
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D001096:Arachnid Vectors / Q000821:virology*; D016466:CHO Cells; D003412:Cricetulus; D034621:Hares / Q000821:virology*; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology* / Q000302:isolation & purification; D006479:Hemorrhagic Fever, Crimean / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007074:Immunoglobulin G / Q000097:blood; D026863:Ixodidae / Q000821:virology*; D011634:Public Health
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G