title: Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index.
abstract: OBJECTIVE
  To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared with healthy controls matched for age and body mass index.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Tertiary teaching hospital.
  
  
  METHODS
  Forty-five women with PCOS and 45 controls paired for age (±2 years) and body mass index (±2 kg/m(2)).
  
  
  METHODS
  Clinical evaluation and venipuncture.
  
  
  METHODS
  Thrombin activatable fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test.
  
  
  RESULTS
  Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups.
  
  
  CONCLUSIONS
  Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability.
authors: Department of Gynecology and Obstetrics, School of Medical Sciences, University of Campinas, São Paulo, Brazil.
authors: Maria Raquel Marques Furtado
authors: MR
authors: de Mendonça-Louzeiro
authors: Joyce Maria
authors: JM
authors: Annichino-Bizzacchi
authors: Luís Alberto
authors: LA
authors: Magna
authors: Susan Kelly Picoli
authors: SK
authors: Quaino
authors: Cristina Laguna
authors: CL
authors: Benetti-Pinto
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D050177:Overweight / Q000097:blood / Q000453:epidemiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology*; D013917:Thrombin / Q000096:biosynthesis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D013917:Thrombin