title: Evolutionary characterization of the pandemic H1N1/2009 influenza virus in humans based on non-structural genes.
abstract: The 2009 influenza pandemic had a tremendous social and economic impact. To study the genetic diversity and evolution of the 2009 H1N1 virus, a mutation network for the non-structural (NS) gene of the virus was constructed. Strains of the 2009 H1N1 pandemic influenza A virus could be divided into two categories based on the V123I mutation in the NS1 gene: G1 (characterized as 123 Val) and G2 (characterized as 123 Ile). Sequence homology analysis indicated that one type of NS sequence, primarily isolated from Mexico, was likely the original type in this pandemic. The two genotypes of the virus presented distinctive clustering features in their geographic distributions. These results provide additional insight into the genetics and evolution of human pandemic influenza H1N1.
authors: National Research Center For Wildlife Born Diseases, Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors: Chengmin
authors: C
authors: Wang
authors: Yanyu
authors: Y
authors: Zhang
authors: Bin
authors: B
authors: Wu
authors: Shelan
authors: S
authors: Liu
authors: Ping
authors: P
authors: Xu
authors: Yanmin
authors: Y
authors: Lu
authors: Jing
authors: J
authors: Luo
authors: Dale Louis
authors: DL
authors: Nolte
authors: Thomas Jude
authors: TJ
authors: Deliberto
authors: Mingxing
authors: M
authors: Duan
authors: Hong
authors: H
authors: Zhang
authors: Hongxuan
authors: H
authors: He
mesh_terms: D019143:Evolution, Molecular; D005787:Gene Frequency; D053263:Gene Regulatory Networks; D014644:Genetic Variation; D005838:Genotype; D005843:Geography; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology; D008957:Models, Genetic; D009154:Mutation; D058873:Pandemics; D010802:Phylogeny; D012641:Selection, Genetic; D013045:Species Specificity; D017361:Viral Nonstructural Proteins / Q000145:classification / Q000235:genetics*
chemical_list: C085820:INS1 protein, influenza virus; C556232:NS2 protein, influenza virus A; D017361:Viral Nonstructural Proteins