title: Cardiovascular and respiratory effects, and quality of anesthesia produced by alfaxalone administered intramuscularly to cats sedated with dexmedetomidine and hydromorphone.
abstract: The cardiovascular and respiratory effects, and the quality of anesthesia of alfaxalone administered intramuscularly (IM) to cats sedated with dexmedetomidine and hydromorphone were evaluated. Twelve healthy adult cats were anesthetized, with six cats receiving dexmedetomidine (0.01 mg/kg IM) followed by alfaxalone (5 mg/kg IM; group DA) and six receiving dexmedetomidine (0.01 mg/kg IM) plus hydromorphone (0.1 mg/kg IM) followed by alfaxalone (5 mg/kg IM; group DHA). Cardiorespiratory (pulse rate, blood pressure, respiratory rate, saturation of oxygen with hemoglobin, end tidal carbon dioxide partial pressure) and bispectral index (BIS) data were collected every 10 mins for 90 mins starting immediately after intubation. The quality of anesthesia was scored by a blinded researcher at induction and at 5 and 60 mins after extubation. Recovery scores ranged from 1 (prolonged struggling) to 4 (no struggling). There were no clinically significant (P >0.05) differences in any data between groups or over time. Physiologic parameters were within normal limits for cats at all times. BIS values were consistent with light anesthesia in both groups. However, recovery was prolonged and marked with excitement, ataxia and hyper-reactivity in all cats. Thus, although cardiovascular and respiratory parameters are stable following IM injection of alfaxalone to cats sedated with dexmedetomidine and hydromorphone, recovery is extremely poor and this route of administration is not recommended for anesthesia in cats.
authors: Veterinary Clinical Sciences Department, Washington State University, Pullman, WA, USA.
authors: Tamara L
authors: TL
authors: Grubb
authors: Stephen A
authors: SA
authors: Greene
authors: Tania E
authors: TE
authors: Perez
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology; D000762:Anesthesia Recovery Period; D000777:Anesthetics / Q000008:administration & dosage*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002415:Cats / Q000502:physiology*; D056805:Consciousness Monitors / Q000662:veterinary; D020927:Dexmedetomidine / Q000008:administration & dosage; D005260:Female; D004091:Hydromorphone / Q000008:administration & dosage; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D011277:Pregnanediones / Q000008:administration & dosage*; D012119:Respiration / Q000187:drug effects*
chemical_list: D000701:Analgesics, Opioid; D000777:Anesthetics; D006993:Hypnotics and Sedatives; D011277:Pregnanediones; D020927:Dexmedetomidine; C006477:alphaxalone; D004091:Hydromorphone