title: Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays and protons in action.
abstract: According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams.
authors: Institute of Biophysics Brno, Academy of Sciences of the Czech Republic, Brno, Czech Republic; Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia; Institute of Chemical Technology Prague, Prague, Czech Republic.
authors: Lucie
authors: L
authors: Ježková
authors: Martin
authors: M
authors: Falk
authors: Iva
authors: I
authors: Falková
authors: Marie
authors: M
authors: Davídková
authors: Alena
authors: A
authors: Bačíková
authors: Lenka
authors: L
authors: Štefančíková
authors: Jana
authors: J
authors: Vachelová
authors: Anna
authors: A
authors: Michaelidesová
authors: Emilie
authors: E
authors: Lukášová
authors: Alla
authors: A
authors: Boreyko
authors: Evgeny
authors: E
authors: Krasavin
authors: Stanislav
authors: S
authors: Kozubek
mesh_terms: D002467:Cell Nucleus / Q000528:radiation effects; D002478:Cells, Cultured; D002843:Chromatin / Q000737:chemistry*; D004249:DNA Damage; D004260:DNA Repair; D005720:Gamma Rays; D006801:Humans; D008853:Microscopy; D011522:Protons; D014178:Translocation, Genetic
chemical_list: D002843:Chromatin; D011522:Protons
keywords: DNA double-strand breaks (DSBs); Formation of chromosomal translocations; Gamma rays and proton beams; Higher-order chromatin structure and DSB repair; γH2AX foci