title: A retrospective analysis of 140 patients with giant cell tumor in the extremity: a multicenter study based on four hospitals in South China.
abstract: BACKGROUND
  Update reports are rarely available regarding the bone giant cell tumors (GCTs) in the extremity in Chinese people. The aim of this study was to review the epidemiological characteristics of bone GCT in the extremity based on the clinical data from four hospitals in South China.
  
  
  METHODS
  We searched medical electronic records from January 2001 to December 2011 in four hospitals in South China to identify patients with definite diagnosis of extremity GCT. Epidemiological data including gender, tumor site, age at the time of first diagnosis, local recurrence and pulmonary metastasis were collected and analyzed statistically. Differences between-genders were particularly analyzed regarding first diagnosis age, tumor site, local recurrence and pulmonary metastasis. T-test and Chi-square test were used for continuous and dichotomous variables, respectively.
  
  
  RESULTS
  A total of 140 GCT patients (87 males and 53 females) were identified. The gender ratio was 1.64 for a male predominance. GCTs were mostly located around the knee (67 cases). 92 patients were in their 20s to 40s upon first diagnosis. The average age at the time of first diagnosis for all was 30.49 years, 30.76 years for males and 30.06 years for females (P = 0.757). GCT recurred locally in 50 patients (26 males and 24 females) with no gender difference (P = 0.065). The average interval from first surgery to local recurrence was 21.42 months. Pulmonary metastasis was found in 11 patients (8 males and 3 females) also with no gender difference (P = 0.667). The average interval from first diagnosis to metastasis was 36.45 months.
  
  
  CONCLUSIONS
  Extremity GCT may have a male predominance in Chinese population and mostly occur at 20-40 years of age and around the knee. Follow-ups for GCT patients should be carried on for at least 3 years after primary surgery according to the average intervals for possible local recurrence and pulmonary metastasis.
authors: Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, PR China. hnxyjn@126.com
authors: Nan
authors: N
authors: Jiang
authors: Cheng-he
authors: CH
authors: Qin
authors: Cai-xia
authors: CX
authors: Tan
authors: Shi-feng
authors: SF
authors: Wen
authors: Yun-fei
authors: YF
authors: Ma
authors: Fu
authors: F
authors: Dong
authors: Xi-cai
authors: XC
authors: Diao
authors: Peng
authors: P
authors: Zhang
authors: Bin
authors: B
authors: Yu
mesh_terms: D000328:Adult; D001132:Arm / Q000473:pathology; D001859:Bone Neoplasms / Q000453:epidemiology* / Q000473:pathology; D002681:China / Q000453:epidemiology; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D007866:Leg / Q000473:pathology; D008297:Male; D012189:Retrospective Studies