title: Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis.
abstract: Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 1-5, including two new metabolites,  11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR (1H-1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.
authors: Department of Thoracic Cardiovascular Surgery, Antai Medical Care Cooperation,  Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan. wyr924@ms24.hinet.net.
authors: Ching-Chyuan
authors: CC
authors: Su
authors: Bing-Sang
authors: BS
authors: Wong
authors: Chuen
authors: C
authors: Chin
authors: Yu-Jen
authors: YJ
authors: Wu
authors: Jui-Hsin
authors: JH
authors: Su