title: Pneumotoxicosis in sheep caused by ingestion of trema micrantha.
abstract: Trema micrantha, a fast-growing tree distributed throughout the Americas, produces palatable leaves that have been associated with hepatic necrosis and acute death when consumed by livestock. This report describes fatal pulmonary disease of sheep triggered by consumption of Trema micrantha. Affected sheep had severe progressive dyspnea for a few days before death. Subcutaneous and mediastinal emphysema, reddened lungs, interalveolar septal thickening, and diffuse type II pneumocyte proliferation were the main pathological findings. After ingesting 77.5 and 102.5 g/kg (divided in 3 doses, at 30-day intervals) of T. micrantha leaves, 2 additional sheep developed the same condition. These findings indicate that T. micrantha toxicosis should be considered in the differential diagnosis of ovine respiratory disease.
authors: Departamento de Patologia Clínica, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves 9090, Agronomia, Porto Alegre-RS, Brazil.
authors: F
authors: F
authors: Wouters
authors: A T B
authors: AT
authors: Wouters
authors: T T N
authors: TT
authors: Watanabe
authors: M P
authors: MP
authors: Soares
authors: C E F
authors: CE
authors: Cruz
authors: D
authors: D
authors: Driemeier
mesh_terms: D000818:Animals; D001938:Brazil; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D008168:Lung / Q000473:pathology; D008478:Mediastinal Emphysema / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D010947:Plants, Toxic / Q000009:adverse effects; D011041:Poisoning / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology*; D034402:Trema / Q000633:toxicity*
keywords: Trema micrantha; pneumotoxicity; respiratory insufficiency; sheep