title: Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis.
abstract: Ischemic stroke (IS) is a complex multifactorial inherited disease. Many studies have focused on the potential genetic effects of apolipoprotein E (ApoE) gene polymorphism on IS. However, inconsistencies still exist in the association of ApoE gene polymorphism with IS. The aim of this study was to investigate the ApoE gene polymorphism in relation to IS in the Guangxi Han populations and assess the risk of various ApoE genotypes associated with IS in Chinese populations. We conducted a case-control study involving a total of 166 IS cases and 192 healthy controls to investigate the association of ApoE gene polymorphism with IS in the Guangxi Han populations. Furthermore, we performed a meta-analysis to investigate whether the ApoE gene polymorphism is associated with IS in Chinese populations. There was no evidence for a significant association between ApoE gene polymorphism and IS in the Guangxi Han populations (ɛ2/ɛ2 vs. ɛ3/ɛ3: OR=1.25, 95% CI=0.08-20.17; ɛ2/ɛ3 vs. ɛ3/ɛ3: OR=1.49, 95% CI=0.79-2.79; ɛ2/ɛ4 vs. ɛ3/ɛ3: OR=1.25, 95% CI=0.17-9.00; ɛ3/ɛ4 vs. ɛ3/ɛ3: OR=1.10, 95% CI=0.60-2.04; ɛ4/ɛ4 vs. ɛ3/ɛ3: OR=2.50, 95% CI=0.22-27.87; allele ɛ2 vs. allele ɛ3: OR=1.39, 95% CI=0.80-2.44; allele ɛ4 vs. allele ɛ3: OR=1.16, 95% CI=0.68-1.98). In our meta-analysis, a significant association of ApoE gene polymorphism with IS was found in the genetic model of ɛ2/ɛ4 vs. ɛ3/ɛ3 (OR=2.04, 95% CI=1.45-2.85), ɛ3/ɛ4 vs. ɛ3/ɛ3 (OR=1.93, 95% CI=1.42-2.62), ɛ4/ɛ4 vs. ɛ3/ɛ3 (OR=3.41, 95% CI=2.17-5.34) and allele ɛ4 vs. allele ɛ3 (OR=2.34, 95% CI=1.91-2.86). However, no clear associations were found in the model of ɛ2/ɛ2 vs. ɛ3/ɛ3 (OR=1.56, 95% CI=0.90-2.71), ɛ2/ɛ3 vs. ɛ3/ɛ3 (OR=0.93, 95% CI=0.79-1.09) and allele ɛ2 vs. allele ɛ3 (OR=1.10, 95% CI=0.97-1.25). In conclusion, no association was found between ApoE gene polymorphism and IS in the Guangxi Han populations, while the results of the meta-analysis indicate that the ApoE mutation allele ɛ4 increases the risk of IS in Chinese populations.
authors: Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi 530023;
authors: Lian
authors: L
authors: Gu
authors: Li
authors: L
authors: Su
authors: Qing
authors: Q
authors: Chen
authors: Baoyun
authors: B
authors: Liang
authors: Yuwang
authors: Y
authors: Qin
authors: Juanjuan
authors: J
authors: Xie
authors: Guangliang
authors: G
authors: Wu
authors: Yan
authors: Y
authors: Yan
authors: Jianxiong
authors: J
authors: Long
authors: Huayu
authors: H
authors: Wu
authors: Jinjing
authors: J
authors: Tan
authors: Weihua
authors: W
authors: Dou
authors: Wei
authors: W
authors: Chen
authors: Peng
authors: P
authors: Wu
authors: Jinping
authors: J
authors: Wang
keywords: apolipoprotein E gene; association study; ischemic stroke; meta-analysis; polymorphism