title: Changes of the expressions of immune-related genes after ventromedial hypothalamic lesioning. Systematic review of the literature.
abstract: Over the past 20 years, the functional autonomy of both the immune and central nervous systems has been successfully challenged. Although the ventromedial hypothalamus (VMH) is one of the centers of parasympathetic nervous system, to date, there has been little reported regarding the role of the hypothalamus in directly changing the expression of immune-related genes. Recently, it has been reported that VMH lesions can directly change the expression of immune-related gene families. The present review focuses on the relationships between the VMH and the expressions of immune-related genes.
authors: Division of Modern Medical Technology, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, 737-0023, Japan. kibat@kure-nh.go.jp
authors: Takayoshi
authors: T
authors: Kiba
authors: Kiyomi
authors: K
authors: Yagyu
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D014697:Ventromedial Hypothalamic Nucleus / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*
chemical_list: D016207:Cytokines