title: Palladium-catalyzed decarboxylative allylation and benzylation of N-alloc and N-Cbz indoles.
abstract: A set of general methods for the palladium-catalyzed decarboxylative C3-allylation and C3-benzylation of indoles, starting from the corresponding N-alloc and N-Cbz indoles, respectively, is reported. This chemistry provides ready access to a wide range of functionalized indolenines in good to excellent yields. A tandem process, wherein the palladium catalyzed allylation chemistry is coupled with a Mizoroki-Heck reaction, offers a simple route to cinnamylated products.
authors: Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.
authors: Thomas D
authors: TD
authors: Montgomery
authors: Ye
authors: Y
authors: Zhu
authors: Natsuko
authors: N
authors: Kagawa
authors: Viresh H
authors: VH
authors: Rawal
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D007211:Indoles; D010165:Palladium