title: Test-retest reproducibility of [11C]-(+)-propyl-hexahydro-naphtho-oxazin positron emission tomography using the bolus plus constant infusion paradigm.
abstract: We examined the reproducibility of using the constant infusion paradigm for equilibrium measurement of D2/3 receptors using [11C]-(+)-propyl-hexahydro-naphtho-oxazin (PHNO) positron emission tomography (PET). Six subjects were scanned with a bolus plus constant infusion (Kbol = 80 minutes) of [11C]-(+)-PHNO. Binding potential (BPND) was computed using the equilibrium approach and compared to a simplified reference tissue model (SRTM). The rate of change in the concentration-activity curve from 60 to 90 minutes was -5 ± 13%/h in the caudate, putamen, substantia nigra, thalamus, and cerebellum but was 15 ± 15%/h in the ventral striatum and pallidum. Test-retest variability was lower in striatal compared to extrastriatal regions (4 ± 8% vs -8 ± 22%, respectively) using the equilibrium approach, with comparable results with SRTM. The equilibrium ratio and SRTM yielded reliable BPND estimates (intraclass correlation coefficient = 0.88 and 0.82, respectively). These studies support the reproducibility of the bolus plus constant infusion paradigm with [11C]-(+)-PHNO PET.
authors: Department of Psychiatry, Yale University School of Medicine, Yale University, New Haven, CT 06516, USA.
authors: Dianne E
authors: DE
authors: Lee
authors: Jean-Dominique
authors: JD
authors: Gallezot
authors: Ming-Qiang
authors: MQ
authors: Zheng
authors: Keunpoong
authors: K
authors: Lim
authors: Yu-Shin
authors: YS
authors: Ding
authors: Yiyun
authors: Y
authors: Huang
authors: Richard E
authors: RE
authors: Carson
authors: Evan D
authors: ED
authors: Morris
authors: Kelly P
authors: KP
authors: Cosgrove
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D017448:Receptors, Dopamine D2