title: [Syphilis].
abstract: Syphilis is back since 2000. Early syphilis comprises primary syphilis, secondary syphilis and early latent syphilis (less than 1 year duration). During early phases of syphilis, patients are more contagious and neurologic complications are rare. Early neurosyphilis are mostly represented by uveitis or cranial nerves lesions. Treatment of non-neurologic syphilis are based on intramusculary injection of benzathine-penicilline G: one injection in case of early syphilis, three injections in case of late syphilis. The follow-up after treatment is based on clinical evolution and the titer of VDRL. Intravenously infusion of penicillin G is the only treatment recommended for neurosyphilis.
authors: AP-HP, hôpital Cochin, service de dermatologie, université Paris Descartes, CNR de la syphilis, UPRES EA1833, 75006 Paris, France. nicolas.dupin@cch.aphp.fr
authors: Nicolas
authors: N
authors: Dupin
authors: David
authors: D
authors: Farhi
mesh_terms: D000328:Adult; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D004334:Drug Administration Schedule; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D008297:Male; D009494:Neurosyphilis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D010400:Penicillin G / Q000627:therapeutic use; D010401:Penicillin G Benzathine / Q000627:therapeutic use; D011159:Population Surveillance; D011247:Pregnancy; D013587:Syphilis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission; D013591:Syphilis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D013592:Syphilis, Latent / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission
chemical_list: D010400:Penicillin G; D010401:Penicillin G Benzathine