title: Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases.
abstract: Neurodegenerative disorders are undoubtedly an increasing problem in the health sciences, given the increase of life expectancy and occasional vicious life style. Despite the fact that the mechanisms of such diseases are far from being completely understood, a large number of studies that derive from both the basic science and clinical approaches have contributed substantial data in that direction. In this review, it is discussed several frontiers of basic research on Parkinson's and Alzheimer's diseases, in which research groups from three departments of the Institute of Biomedical Sciences of the University of São Paulo have been involved in a multidisciplinary effort. The main focus of the review involves the animal models that have been developed to study cellular and molecular aspects of those neurodegenerative diseases, including oxidative stress, insulin signaling and proteomic analyses, among others. We anticipate that this review will help the group determine future directions of joint research in the field and, more importantly, set the level of cooperation we plan to develop in collaboration with colleagues of the Nucleus for Applied Neuroscience Research that are mostly involved with clinical research in the same field.
authors: Department of Physiology and Biophysics, Institute of Biomedical Sciences, Universidade de São Paulo, Brazil.
authors: Andréa S
authors: AS
authors: Torrão
authors: Cecilia C
authors: CC
authors: Café-Mendes
authors: Caroline C
authors: CC
authors: Real
authors: Marina S
authors: MS
authors: Hernandes
authors: Ana F B
authors: AF
authors: Ferreira
authors: Taisa O
authors: TO
authors: Santos
authors: Gabriela P
authors: GP
authors: Chaves-Kirsten
authors: Caio H Y
authors: CH
authors: Mazucanti
authors: Emer S
authors: ES
authors: Ferro
authors: Cristoforo
authors: C
authors: Scavone
authors: Luiz R G
authors: LR
authors: Britto
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000473:pathology; D004195:Disease Models, Animal; D015444:Exercise / Q000502:physiology; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D010300:Parkinson Disease / Q000209:etiology / Q000378:metabolism*; D010455:Peptides / Q000032:analysis; D040901:Proteomics
chemical_list: D015415:Biomarkers; D010455:Peptides; D019255:NADPH Oxidases