title: Negative symptoms in schizophrenia.
abstract: Clinical heterogeneity is a confound common to all of schizophrenia research. Deficit schizophrenia has been proposed as a homogeneous disease entity within the schizophrenia syndrome. Utilizing the Schedule for the Deficit Syndrome (SDS) has allowed the definition of a subgroup dominated by persistent clusters of negative symptoms. While a number of studies have appeared over the years examining the electrophysiological correlates of the cluster of negative symptoms in schizophrenia, only a few studies have actually focused on the deficit syndrome (DS). PubMed as well as MEDLINE were searched for all reports indexed for "negative symptoms" or "deficit syndrome" and one of the following electrophysiology assessment tools: electroencephalography (EEG), evoked potentials (EPs), or polysomnography (PSG). While this line of research is evidently in its infancy, two significant trends emerge. First, spectral EEG studies link increased slow wave activity during wakefulness to the prevalence of negative symptoms. Secondly, sleep studies point to an association between decrease in slow wave sleep and prevalence of negative symptoms. Several studies also indicate a relationship of negative symptoms with reduced alpha activity. A host of other abnormalities--including sensory gating and P300 attenuation--are less consistently reported. Two studies specifically addressed electrophysiology of the DS. Both studies provided evidence suggesting that the DS may be a separate disease entity and not simply a severe form of schizophrenia.
authors: Department of Psychiatry and Neurosciences, University of Missouri in Kansas City (UMKC), Kansas City, MO.
authors: Nash N
authors: NN
authors: Boutros
authors: Department of Psychiatry, University of Naples SUN, Naples, Italy.
authors: Armida
authors: A
authors: Mucci
authors: Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI.
authors: Vaibhav
authors: V
authors: Diwadkar
authors: Department of Psychiatry, University of Florida College of Medicine, Gainsville, FL.
authors: Rajiv
authors: R
authors: Tandon
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D055724:Electrophysiological Phenomena / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D017286:Polysomnography / Q000379:methods; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents
keywords: Deficit Syndrome; Electroencephalography (EEG); Evoked Potentials (EPs); Negative Symptoms; Polysomnography (PSG); Schizophrenia