title: Nutritional status is associated with health-related quality of life in children with cystic fibrosis aged 9-19 years.
abstract: BACKGROUND
  The impact of improved nutritional status on health-related quality of life (HRQOL) is unknown for children with cystic fibrosis (CF).
  
  
  METHODS
  Associations between nutritional status and HRQOL were examined over 2 years in 95 children, aged 9-19 years, who were followed in the Wisconsin Newborn Screening Project. HRQOL was assessed using the Cystic Fibrosis Questionnaire (CFQ). Associations between height z-score (HtZ), BMI z-score (BMIZ) and seven CFQ dimensions were evaluated.
  
  
  RESULTS
  Mean values of at least 80 were observed for all CFQ dimensions except respiratory symptoms and treatment burden. Treatment burden was significantly worse in patients with meconium ileus (57) compared to pancreatic insufficient (65) and sufficient (78) subjects, p<0.0001. HtZ and BMIZ were positively associated with physical functioning and body image (p<0.05).
  
  
  CONCLUSIONS
  Better nutritional status was associated with increased HRQOL scores. Early diagnosis through newborn screening and improved nutrition provides an opportunity to enhance quality of life and body image perception.
authors: University of Wisconsin College of Agriculture and Life Sciences, Department of Nutritional Sciences, 1415 Linden Drive, Madison, WI 53706, USA; University of Wisconsin School of Nursing, K6/346 Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792, USA; University of Wisconsin School of Medicine and Public Health, Department of Pediatrics, K4/922 Clinical Sciences Center, 600 Highland Ave., Madison, WI 53792, USA; University of Wisconsin School of Medicine and Public Health, Departments of Pediatrics and Population Health Sciences, WARF Building, Room 756, 610 Walnut St., Madison, WI 53726, USA.
authors: Suzanne M
authors: SM
authors: Shoff
authors: Audrey
authors: A
authors: Tluczek
authors: Anita
authors: A
authors: Laxova
authors: Philip M
authors: PM
authors: Farrell
authors: HuiChuan J
authors: HJ
authors: Lai
mesh_terms: D000293:Adolescent; D002648:Child; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000503:physiopathology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D009752:Nutritional Status; D010179:Pancreas / Q000503:physiopathology; D011788:Quality of Life; D055815:Young Adult
keywords: cystic fibrosis; nutrition; quality of life