title: [Effect of periodontal therapy on metabolic control and serum biochemical markers in subjects with type 2 diabetes and chronic periodontitis].
abstract: OBJECTIVE
  To investigate the effect of periodontal therapy on periodontal clinical index, metabolic control and serum biochemical markers in subjects  with type 2 diabetes and chronic periodontitis comprehensively.
  
  
  METHODS
  Forty patients with type 2 diabetes and chronic periodontitis were enrolled,  and periodontal clinical parameters, HbA1c, fasting blood glucose (FBG) and serum biochemical markers were tested at baseline and 3 months after  initial periodontal therapy.
  
  
  RESULTS
  The periodontal clinical parameters (PLI, BI,PD,CAL and BOP) improved significantly 3 months after initial  periodontal therapy (P<0.001). The HbA1c also decreased statistically (P=0.014), while there was no change in venous fasting blood glucose. Other  serum biochemical markers changed significantly including serum phosphor increased, calcium-phosphorus ratio decreased, triglyceride decreased,  Apo A1 increased, lipoprotein a decreased, and serum total bilirubin increased.
  
  
  CONCLUSIONS
  The initial periodontal therapy can significantly improve  periodontal clinical parameters and HbA1c control, but the effect on venous fasting blood glucose was not revealed yet. In addition, initial periodontal  therapy can also intervene serum phosphorus,calcium-phosphorus ratio, and the metabolism of lipid.
authors: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
authors: Jing-ling
authors: JL
authors: Xu
authors: Huan-xin
authors: HX
authors: Meng
authors: Zheng
authors: Z
authors: Li
authors: Feng-yuan
authors: FY
authors: Li
authors: Lin
authors: L
authors: Zhang
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D055113:Chronic Periodontitis / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008055:Lipids; C517652:hemoglobin A1c protein, human