title: The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma.
abstract: Renal cell carcinoma (RCC) is one of the most common malignant neoplasms in the urinary system, and has a high frequency of local invasion and distant metastasis. This study assessed the expression and clinical significance of matrix metalloproteinase 7 (MMP-7) and tissue inhibitor of matrix metalloproteinases 2 (TIMP-2) in human clear cell renal cell carcinoma (CCRCC) by tissue microarray, immunohistochemistry and RT-PCR analysis. The expression of MMP-7 in CCRCC tissues was significantly higher compared with that in the control group (CG) and TIMP-2 expression in CCRCC, by contrast, was lower compared with that in the CG. The expression of MMP-7 and TIMP-2 in the CCRCC tissues was significantly correlated with the pathological grade and clinical stage. Log-rank analyses indicated that upregulation of MMP-7 and downregulation of TIMP-2 expression may occur during the progression of CCRCC, and Cox multivariate survival rate analysis demonstrated that there was also a positive correlation between the pathological grade, clinical stage, MMP-7 expression and survival rate. Thus, MMP-7 is an independent prognostic factor and MMP-7 and TIMP-2 may serve as useful molecular markers for evaluating prognosis in CCRCC patients.
authors: Department of Pathology, Taizhou Central Hospital of Taizhou Enze Medical Group, Taizhou 318000;
authors: Hongsheng
authors: H
authors: Lu
authors: Zhaohui
authors: Z
authors: Yang
authors: Hui
authors: H
authors: Zhang
authors: Meifu
authors: M
authors: Gan
authors: Tao
authors: T
authors: Zhou
authors: Siling
authors: S
authors: Wang
keywords: clear cell renal cell carcinoma; matrix metalloproteinase 7; prognosis; tissue inhibitor of matrix metalloproteinases 2; tissue microarray