title: Cord-blood lipoproteins, homocysteine, insulin sensitivity/resistance marker profile, and concurrence of dysglycaemia and dyslipaemia in full-term neonates of the Mérida Study.
abstract: Early alterations in glucose homeostasis increase the risk of developing insulin resistance and obesity later in life. The concurrence of altered lipids and insulin sensitivity/resistance markers at birth has been scarcely investigated. The study aimed to ascertain level ranges of homocysteine (tHcyt), arylesterase (AE), lipids/lipoproteins, and insulin resistance/sensitivity markers in full-term neonates and to determine the concurrence effect of dyslipaemia and dysglycaemia on those parameters at birth. Participants were 197 full-term, 2.5 to <4.0 kg, without foetal distress Spanish newborns from the Mérida Study. Parameter percentiles for males and females were stated. The effect of the concurrence high glucose/high triglycerides (high glucose/high TG) or high glucose/low cholesterol transported by HDL (HDL-c) on tHcyt, LDL-c, HDL-c, lipoprotein (a) (Lp(a)), oxidised LDL (oxLDL), AE, glucose, insulin sensitivity (QUICKI) and insulin resistance index (HOMA-IR) was studied. Females had higher total cholesterol (TC), HDL-c, Apo A1, Lp(a) and HDL-c/Apo A1, but lower relative transport of TC (%TC) by the very low lipoprotein fraction than males. No gender differences were found for glucose, HOMA-IR and QUICKI. Neonates at the 2.5- to 2.999-kg range display more adequate HOMA-IR and QUICKI levels that their >3.0 kg counterparts. The concurrence of high glucose/high TG or high glucose/low HDL-c increased TC/HDL-c and HOMA-IR, but decreased, oxLDL, oxLDL/LDL-c and QUICKI with respect to that of low glucose/low TG or glucose/high HDL-c. The concurrence glucose/TG has predictive value for low QUICKI, whilst that of glucose/HDL-c for low QUICKI and high HOMA-IR, suggesting the importance of routine TG, HDL-c and glucose screening at birth as it would identify candidates for insulin resistance.
authors: Servicio de Análisis Clínicos, Hospital de Mérida, Mérida, Badajoz, Spain.
authors: Eva
authors: E
authors: Gesteiro
authors: Sara
authors: S
authors: Bastida
authors: Francisco J
authors: FJ
authors: Sánchez-Muniz
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D001786:Blood Glucose / Q000502:physiology*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D050171:Dyslipidemias / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007333:Insulin Resistance / Q000502:physiology*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D011237:Predictive Value of Tests; D012737:Sex Factors; D047929:Term Birth
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008074:Lipoproteins; D006710:Homocysteine; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase