title: Two new sesquiterpenoids from the rhizomes of Nardostachys jatamansi.
abstract: Phytochemical investigation of CHCl(3):MeOH (1:1) extract from the rhizomes of Nardostachys jatamansi led to the isolation of two new sesquiterpenoids (5 and 6), along with six known compounds (1-4, 7, and 8). The structures of two new compounds were established using IR, MS, 1D, and 2D NMR techniques. In addition, all the isolates were tested for their cytotoxicities against the A549 (lung cancer), DU-145 (prostate cancer), MCF-7 (breast cancer), and SK-N-SH (neuroblastoma).
authors: Division of Natural Product Chemistry, Natural Product Laboratory, CSIR-Indian Institute of Chemical Technology, Tarnaka , Hyderabad 500 607, India.
authors: K
authors: K
authors: Rekha
authors: R Ranga
authors: RR
authors: Rao
authors: Richa
authors: R
authors: Pandey
authors: Kothakonda Rajendra
authors: KR
authors: Prasad
authors: Katragadda Suresh
authors: KS
authors: Babu
authors: Janakiram R
authors: JR
authors: Vangala
authors: Sashi V
authors: SV
authors: Kalivendi
authors: Janaswamy Madhusudana
authors: JM
authors: Rao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D015394:Molecular Structure; D032404:Nardostachys / Q000737:chemistry*; D009447:Neuroblastoma / Q000188:drug therapy; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C579832:nardin A; C579833:nardin B