title: Association between single nucleotide polymorphisms of the transforming growth factor-β1 gene and overall survival in unresectable locally advanced non-small-cell lung cancer patients treated with radio(chemo)therapy in a Chinese population.
abstract: The outcome is variable for unresectable locally advanced non-small-cell lung cancer (ULANSCLC) patients treated with radio(chemo)therapy. The aim of this study is to investigate whether single-nucleotide polymorphisms (SNPs) in the transforming growth factor-beta1 (TGF-β1) gene are associated with overall survival (OS) in ULANSCLC patients treated with definitive radio(chemo)therapy. A total of 109 patients who had available blood samples and complete clinical and follow-up information were enrolled. DNA from blood was genotyped for two SNPs: TGF-β1 C-509T and T+869C. Kaplan-Meier survival analysis, log-rank test, and Cox's proportional hazard model were used to evaluate associations between genotypes and OS. Log-rank test showed that TGF-β1 C-509T significantly correlated with OS (pooled P = 0.017). Both univariate and multivariate analyses showed that TGF-β1 C-509T CC genotype was significantly associated with better OS than CT or TT genotypes. These results indicate that TGF-β1 C-509T CC genotype is significantly associated with better OS in ULANSCLC patients treated with radio(chemo)therapy as a potential independent survival predictor.
authors: Department of Radiation Oncology and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical College, 2 Fuxuexiang Road, Wenzhou 325002, Zhejiang, People's Republic of China.
authors: Sheng-Liu
authors: SL
authors: Xue
authors: Yi-Hu
authors: YH
authors: Zheng
authors: Hua-Fang
authors: HF
authors: Su
authors: Xia
authors: X
authors: Deng
authors: Xue-Bang
authors: XB
authors: Zhang
authors: Chang-Lin
authors: CL
authors: Zou
authors: Mei-Long
authors: ML
authors: Hu
authors: Cong-Ying
authors: CY
authors: Xie
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000208:ethnology / Q000235:genetics* / Q000628:therapy; D059248:Chemoradiotherapy / Q000639:trends; D015331:Cohort Studies; D005260:Female; D056726:Genetic Association Studies / Q000639:trends; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D053773:Transforming Growth Factor beta1