title: Neurobehavioral and genotoxic evaluation of (-)-linalool in mice.
abstract: (-)-Linalool is a monoterpene compound commonly found as a major component of the essential oil of several aromatic species. It has been shown to exert several actions in the central nervous system (CNS) and is able to inhibit glutamate receptors. This study investigated the effect of (-)-linalool in depression and genotoxicity models. Mice were given (-)-linalool (10, 50, 100 or 200 mg/kg i.p.) and were evaluated using the tail suspension test (TST). Genotoxic and antigenotoxic effects in blood and brain were investigated using the alkaline comet assay. In the TST, the animals that received doses of 100 and 200 mg/kg presented a decrease in immobility times. No increase in DNA damage was observed in either tissue, and resistance to DNA oxidative damage induced by hydrogen peroxide did not increase. (-)-Linalool showed an antidepressant-like activity in the TST and was unable to cause damage/protection to DNA in brain tissue and peripheral blood. This investigation provides evidence of an important effect of (-)-linalool on the CNS; however, more studies are necessary to support its possible clinical uses.
authors: Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, Porto Alegre, RS, Brazil.
authors: Vanessa
authors: V
authors: Coelho
authors: Leidiane
authors: L
authors: Mazzardo-Martins
authors: Daniel Fernandes
authors: DF
authors: Martins
authors: Adair Roberto Soares
authors: AR
authors: Santos
authors: Lucimar Filot
authors: LF
authors: da Silva Brum
authors: Jaqueline Nascimento
authors: JN
authors: Picada
authors: Patrícia
authors: P
authors: Pereira
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects; D008297:Male; D051379:Mice; D039821:Monoterpenes / Q000494:pharmacology* / Q000633:toxicity; D009153:Mutagens / Q000633:toxicity
chemical_list: D000080462:Acyclic Monoterpenes; D000928:Antidepressive Agents; D039821:Monoterpenes; D009153:Mutagens; C018584:linalool