title: Effects of selenium and zinc status in biological samples of hepatitis C patient after herbal and pharmaceutical supplements.
abstract: The use of natural remedies and pharmacological mineral supplements for liver disease treatment has a long history. In present study, the levels of selenium (Se) and zinc (Zn) were determined in biological samples (serum and whole blood) of female hepatitis C patients (n = 132), age ranged 30-45 years, before and after 30 days treatment with herbal/pharmaceutical supplements. For comparative study, 128 age-matched female subjects, residing in the same residential areas and have socioeconomic status, were selected as referents. The Se and Zn in supplements, blood, and sera were determined by atomic absorption spectrometry. It was observed that Zn and Se in blood and serum samples of viral hepatitis C (HCV) patients were reduced in the range of 28.6-39 % and 24-36 %, respectively, as compared to those of referents. After herbal/pharmaceutical supplementations, 20.6-25.0 and 9.15-13.2 % of Zn and 10.6-12.1 and 19.6-21.4 % of Se were enhanced in sera and blood samples of HCV patients, respectively. The resulted data indicated that the levels of Se and Zn in addition to some biochemical parameters were improved in HCV patients after herbal/pharmaceutical supplementation. The effects of both supplements were not significantly different (p > 0.05).
authors: National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan. nidafatima6@gmail.com
authors: Nida F
authors: NF
authors: Kolachi
authors: Tasneem G
authors: TG
authors: Kazi
authors: Hassan I
authors: HI
authors: Afridi
authors: Naveed G
authors: NG
authors: Kazi
authors: Moeena A
authors: MA
authors: Mughal
authors: Sumaira
authors: S
authors: Khan
mesh_terms: D000328:Adult; D019587:Dietary Supplements; D005260:Female; D006526:Hepatitis C / Q000097:blood* / Q000178:diet therapy / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D012643:Selenium / Q000097:blood*; D014131:Trace Elements / Q000097:blood; D015032:Zinc / Q000097:blood*
chemical_list: D014131:Trace Elements; D012643:Selenium; D015032:Zinc