title: Identifying risk factors of immune reconstitution inflammatory syndrome in AIDS patients receiving highly active anti-retroviral therapy.
abstract: Immune reconstitution inflammation syndrome typically occurs within days after patients undergo highly active anti-retroviral therapy and is a big hurdle for effective treatment of AIDS patients. In this study, we monitored immune reconstitution inflammation syndrome occurrence in 238 AIDS patients treated with highly active anti-retroviral therapy. Among them, immune reconstitution inflammation syndrome occurred in 47 cases (19.7%). Immune reconstitution inflammation syndrome patients had significantly higher rate of opportunistic infection (p<0.001) and persistently lower CD4(+) cell count (p<0.001) compared to the non-immune reconstitution inflammation syndrome patients. In contrast, no significant differences in HIV RNA loads were observed between the immune reconstitution inflammation syndrome group and non-immune reconstitution inflammation syndrome group. These data suggest that a history of opportunistic infection and CD4(+) cell counts at baseline may function as risk factors for immune reconstitution inflammation syndrome occurrence in AIDS patients as well as potential prognostic markers. These findings will improve the management of AIDS with highly active anti-retroviral therapy.
authors: Department of Infectious Diseases, AIDS Research Laboratory, Xiangya Second Hospital, Central South University, Changsha, PR China.
authors: Bo
authors: B
authors: He
authors: Yuhuang
authors: Y
authors: Zheng
authors: Meng
authors: M
authors: Liu
authors: Guoqiang
authors: G
authors: Zhou
authors: Xia
authors: X
authors: Chen
authors: Diallo
authors: D
authors: Mamadou
authors: Yan
authors: Y
authors: He
authors: Huaying
authors: H
authors: Zhou
authors: Zi
authors: Z
authors: Chen
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D005260:Female; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000209:etiology*; D008297:Male; D011446:Prospective Studies; D012367:RNA, Viral; D012307:Risk Factors; D019562:Viral Load
chemical_list: D012367:RNA, Viral