title: Cascade synthesis of fenpiprane and related pharmaceuticals via rhodium-catalyzed hydroaminomethylation.
abstract: A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1,1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.
authors: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, P.R. China.
authors: Shengkun
authors: S
authors: Li
authors: Kexuan
authors: K
authors: Huang
authors: Jiwen
authors: J
authors: Zhang
authors: Wenjun
authors: W
authors: Wu
authors: Xumu
authors: X
authors: Zhang
mesh_terms: D000588:Amines / Q000737:chemistry*; D001559:Benzhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008024:Ligands; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000588:Amines; D001559:Benzhydryl Compounds; D008024:Ligands; D012238:Rhodium; C470220:fenpiprane