title: Peptide ligation-desulfurization chemistry at arginine.
abstract: The utility of a new β-thiol arginine building block in ligation-desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one-pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.
authors: School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.
authors: Lara R
authors: LR
authors: Malins
authors: Katie M
authors: KM
authors: Cergol
authors: Richard J
authors: RJ
authors: Payne
mesh_terms: D001120:Arginine / Q000138:chemical synthesis / Q000737:chemistry*; D004952:Esters; D006020:Glycopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D007700:Kinetics; D018396:Mucin-1 / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D004952:Esters; D006020:Glycopeptides; D018396:Mucin-1; D013438:Sulfhydryl Compounds; D001120:Arginine