title: Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth.
abstract: Exosomes are 30-150 nm vesicles secreted by a wide range of mammalian cells that can contain microRNA (miRNA). To test if marrow stromal cell (MSC) exosomes could be used as a vehicle for delivery of anti-tumor miRNAs, we transfected MSCs with a miR-146b expression plasmid, and harvested exosomes released by the MSCs. Intra-tumor injection of exosomes derived from miR-146-expressing MSCs significantly reduced glioma xenograft growth in a rat model of primary brain tumor.
authors: Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
authors: Mark
authors: M
authors: Katakowski
authors: Ben
authors: B
authors: Buller
authors: Xuguang
authors: X
authors: Zheng
authors: Yong
authors: Y
authors: Lu
authors: Thomas
authors: T
authors: Rogers
authors: Oyinkansola
authors: O
authors: Osobamiro
authors: Wayne
authors: W
authors: Shu
authors: Feng
authors: F
authors: Jiang
authors: Michael
authors: M
authors: Chopp
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D055354:Exosomes / Q000378:metabolism*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D035683:MicroRNAs / Q000008:administration & dosage / Q000235:genetics / Q000378:metabolism*; D009368:Neoplasm Transplantation; D051381:Rats; D011916:Rats, Inbred F344; D047368:Tumor Burden
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs