title: Novel methods for quantifying individual host response to infectious pathogens for genetic analyses.
abstract: We propose two novel approaches for describing and quantifying the response of individual hosts to pathogen challenge in terms of infection severity and impact on host performance. The first approach is a direct extension of the methodology for estimating group tolerance (the change in performance with respect to changes in pathogen burden in a host population) to the level of individuals. The second approach aims to capture the dynamic aspects of individual resistance and tolerance over the entire time course of infections. In contrast to the first approach, which provides a means to disentangle host resistance from tolerance, the second approach focuses on the combined effects of both characteristics. Both approaches provide new individual phenotypes for subsequent genetic analyses and come with specific data requirements. In particular, both approaches rely on the availability of repeated performance and pathogen burden measurements of individuals over the time course of one or several episodes of infection. Consideration of individual tolerance also highlights some of the assumptions hidden within the concept of group tolerance, indicating where care needs to be taken in trait definition and measurement.
authors: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh Edinburgh, UK.
authors: Andrea B
authors: AB
authors: Doeschl-Wilson
authors: Steve C
authors: SC
authors: Bishop
authors: Ilias
authors: I
authors: Kyriazakis
authors: Beatriz
authors: B
authors: Villanueva
keywords: breeding for disease resistance; dynamical system; host–pathogen interaction; infection dynamics; infectious disease; random regression; resistance; tolerance