title: On the cytokines produced by human neutrophils in tumors.
abstract: Although traditionally viewed as short-lived innate immunity cells, only playing a crucial role in host defense toward infections, neutrophils have recently become subject of a new wave of research in diverse areas including in tumors. Indeed, increasing experimental evidence indicate that neutrophils may directly or indirectly influence the tumor fate through the release of a wide array of molecules able to exert either pro-tumor or anti-tumor functions depending on the microenvironment milieu, including cytokines. This review therefore attempts to uncover the role that neutrophils play during the different steps of tumor development (from promotion to progression), as well as in anti-tumor responses, via cytokine production.
authors: Department of Medicine, Section of Hematology, School of Medicine, University of Verona, Verona, Italy. cristina.tecchio@univr.it
authors: Cristina
authors: C
authors: Tecchio
authors: Patrizia
authors: P
authors: Scapini
authors: Giovanni
authors: G
authors: Pizzolo
authors: Marco A
authors: MA
authors: Cassatella
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000276:immunology / Q000378:metabolism; D020556:Neutrophil Infiltration / Q000276:immunology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism*
chemical_list: D016207:Cytokines