title: Hypertension increases the risk of cerebral microbleed in the territory of posterior cerebral artery: a study of the association of microbleeds categorized on a basis of vascular territories and cardiovascular risk factors.
abstract: BACKGROUND
  It has been suggested that the etiology of cerebral microbleeds (CMBs) differs according to their location in the brain, with lobar microbleeds being caused by cerebral amyloid angiopathy and deep or infratentorial microbleeds resulting from hypertension and atherosclerosis. We hypothesized that there were associations between cerebral arterial branches, cardiovascular risk factors, and the occurrence of CMBs. We examined these relationships in the current study.
  
  
  METHODS
  Three hundred ninety-three patients with CMBs were analyzed in this study. The CMBs were listed according to the various arterial territories, and these were assessed for their relationship with cardiovascular risk factors, markers of small vessel disease, and their presence and location using multiple logistic regression.
  
  
  RESULTS
  Systolic blood pressure had a significant association with CMBs in the territory of the posterior cerebral artery and the deep and infratentorial locations. The presence of lacunar infarcts, hemorrhage, and white matter changes were associated with CMBs in nearly all arterial territories.
  
  
  CONCLUSIONS
  Hypertension increases the risk of microbleeds in the territory of the posterior cerebral artery and the deep and infratentorial locations. Cerebral amyloid angiopathy may be responsible for the microbleeds in the lobar area of brain.
authors: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: Zhenyu
authors: Z
authors: Jia
authors: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: Wasif
authors: W
authors: Mohammed
authors: Customer Service, Healthcare Sector, Siemens Ltd, Beijing, China.
authors: Yiru
authors: Y
authors: Qiu
authors: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: Xunning
authors: X
authors: Hong
authors: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: jsphradiology@hotmail.com.
authors: Haibin
authors: H
authors: Shi
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000473:pathology; D002536:Cerebral Arteries / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000601:surgery; D002544:Cerebral Infarction / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007091:Image Processing, Computer-Assisted; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures; D020769:Posterior Cerebral Artery / Q000473:pathology*; D012307:Risk Factors
keywords: Cerebral arterial territory; hypertension; magnetic resonance imaging; microbleeds; posterior cerebral artery