title: A cool way to live long.
abstract: In this issue, Xiao et al. challenge the notion that cold temperatures promote longevity solely through thermodynamic effects. They show that low temperatures activate a cold-sensitive cation channel, TRPA-1, which triggers a complex signaling pathway in both neurons and nonneuronal cells to extend the lifespan of Caenorhabditis elegans.
authors: The Scripps Research Institute, Department of Chemical Physiology, La Jolla, CA 92037, USA. bconti@scripps.edu
authors: Bruno
authors: B
authors: Conti
authors: Malene
authors: M
authors: Hansen