title: Interactions of the IGF System with Diabetes and its Vascular Complications.
abstract: The insulin-like growth factor (IGF) system is an evolutionarily conserved group of important proteins that are fundamental to life. Indeed, insulin can be viewed as simply a specialized arm of the IGF system that has evolved to regulate primarily metabolic functions. The main purpose of the IGF system is to form a highly refined mechanism for the control of cellular growth, metabolism and survival. Dysregulation of such a system can have serious consequences. In this review we have focussed on the IGF system and its relation to diabetes and the development of cardiometabolic disorders.
authors: Vascular Research Group, Institute of Population Health, The University of Manchester, Manchester, United Kingdom. ram.narayanan@manchester.ac.uk
authors: R P
authors: RP
authors: Narayanan
authors: K W
authors: KW
authors: Siddals
authors: A H
authors: AH
authors: Heald
authors: J M
authors: JM
authors: Gibson
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000235:genetics; D003925:Diabetic Angiopathies / Q000097:blood / Q000209:etiology* / Q000235:genetics; D004843:Epistasis, Genetic / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013002:Somatomedins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins