title: Insight into the medicinal chemistry of the endocannabinoid hydrolase inhibitors.
abstract: Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.
authors: Medicinal Chemistry, Cannabinoid and Endocannabinoid Research Group, B1.73.10, Louvain Drug Research Institute (LDRI), Université catholique de Louvain, 73 avenue E. Mounier B-1200 Bruxelles, Belgium.
authors: C N
authors: CN
authors: Kapanda
authors: J H
authors: JH
authors: Poupaert
authors: D M
authors: DM
authors: Lambert
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D063388:Endocannabinoids / Q000737:chemistry / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D013329:Structure-Activity Relationship; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D063388:Endocannabinoids; D004791:Enzyme Inhibitors; D000099252:Fatty Acid Amide Hydrolases