title: Complexation of Hypocrellin A with Al3+ in water solution and the photodynamic therapy study.
abstract: The complex of Hypocrellin A with Al(3+) is prepared in water solution by a facile method. The water-solubility and stability of complexes are improved. Irradiation of Al(3+)-HA complex results in higher efficient generation of singlet oxygen ((1)O2) and photocleavage ability to CT DNA than HA. In vitro studies have illustrated that the Al(3+)-HA complex has anti-cancer activity.
authors: Analysis and Testing Center, Jiangsu Key Laboratory of Biofunctional Materials, School of Geograph Science, Nanjing Normal University, Nanjing 210046, PR China.
authors: Fei
authors: F
authors: Ma
authors: Heyong
authors: H
authors: Huang
authors: Xuefeng
authors: X
authors: Ge
authors: Xiaodi
authors: X
authors: Yang
authors: Chao
authors: C
authors: Yang
authors: Lina
authors: L
authors: Han
authors: Jiahong
authors: J
authors: Zhou
authors: Lin
authors: L
authors: Zhou
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D048430:Cell Shape / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006367:HeLa Cells; D006801:Humans; D007477:Ions / Q000737:chemistry; D008027:Light; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D019800:Phenol; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D011809:Quinones / Q000737:chemistry* / Q000633:toxicity; D026082:Singlet Oxygen / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy; D014867:Water
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D007477:Ions; D017319:Photosensitizing Agents; D011809:Quinones; D014867:Water; D026082:Singlet Oxygen; D019800:Phenol; D010569:Perylene; D004247:DNA; D000535:Aluminum; C048388:hypocrellin A