title: Aberrant drainage of sentinel lymph nodes in colon cancer and its impact on staging and extent of operation.
abstract: BACKGROUND
  The role of aberrant lymphatic drainage in changing operations for patients undergoing sentinel lymph node mapping in colon cancer has not been described on a large scale.
  
  
  METHODS
  Patients with colon cancer underwent sentinel lymph node mapping and standard oncologic resection. Aberrant lymphatic drainage was identified outside the standard resection margin, requiring change of the extent of operation. Objectives were to identify the frequency of aberrant lymphatic drainage leading to changes of operation and staging.
  
  
  RESULTS
  Among 192 patients undergoing standard oncologic resection, 42 (22%) had extended surgery because of aberrant lymphatic drainage. Nodal positivity was higher in patients undergoing change of operation, at 62% compared with 43% of those undergoing only standard oncologic resection. In 19 of 192 patients (10%), positive sentinel nodes were found in aberrant locations.
  
  
  CONCLUSIONS
  Sentinel node mapping in patients with colon cancer detects aberrant drainage in 22% of patients, changing the extent of operation.
authors: McLaren Flint, 3500 Calkins Road, Flint, MI 48532, USA. ssahadr@aol.com
authors: Sukamal
authors: S
authors: Saha
authors: Gregory
authors: G
authors: Johnston
authors: Alpesh
authors: A
authors: Korant
authors: Mohammed
authors: M
authors: Shaik
authors: Mohammed
authors: M
authors: Kanaan
authors: Rebecca
authors: R
authors: Johnston
authors: Balvant
authors: B
authors: Ganatra
authors: Sunil
authors: S
authors: Kaushal
authors: Dilip
authors: D
authors: Desai
authors: Sreenivas
authors: S
authors: Mannam
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy / Q000379:methods*; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008196:Lymph / Q000378:metabolism*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D021701:Sentinel Lymph Node Biopsy; D016896:Treatment Outcome