title: Rare localisation of breast cancer metastasis to thyroid gland.
abstract: BACKGROUND
  Metastases to the thyroid gland are very rare. They are usually seen in malignant melanoma, kidney, breast cancer and lung cancer.
  
  
  METHODS
  We presented a 54-years-old female patient with breast cancer diagnosed in 2002. The adequate surgical procedure was done and the tumor and axillary lymph nodes were removed. The patient also received adjuvant postoperative chemotherapy. After seven years of a disease free period, the first relapse of the disease was detected as thyroid gland tumor with axillary lymphadenopathy. The patient had a good response to systemic treatment so the surgical removal of thyroid gland and enlarged lymph nodes was performed. Histopathological analysis confirmed metastasis with breast cancer origin. Radical mastectomy was also preformed. Second relapse of the disease was detected 10 months later, while the patient was on hormonal therapy. It was manifested as the appearance of bone and skin metastases, pleural effusion and lymphadenopathy.
  
  
  CONCLUSIONS
  This case report emphasized the importance of detailed examination of any new onset of thyroid swelling in a patient with previous history of malignancy.
authors: Clinic for Medical Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia. daniela_kolarevic@yahoo.co.uk
authors: Daniela
authors: D
authors: Kolarević
authors: Zorica
authors: Z
authors: Tomasević
authors: Ivan
authors: I
authors: Marković
authors: Milan
authors: M
authors: Zegarac
authors: Gordana
authors: G
authors: Pupić
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000556:secondary*