title: Sequential peritoneal equilibration test: a new method for assessment and modelling of peritoneal transport.
abstract: BACKGROUND
  In spite of many peritoneal tests proposed, there is still a need for a simple and reliable new approach for deriving detailed information about peritoneal membrane characteristics, especially those related to fluid transport.
  
  
  METHODS
  The sequential peritoneal equilibration test (sPET) that includes PET (glucose 2.27%, 4 h) followed by miniPET (glucose 3.86%, 1 h) was performed in 27 stable continuous ambulatory peritoneal dialysis patients. Ultrafiltration volumes, glucose absorption, ratio of concentration in dialysis fluid to concentration in plasma (D/P), sodium dip (Dip D/P Sodium), free water fraction (FWF60) and the ultrafiltration passing through small pores at 60 min (UFSP60), were calculated using clinical data. Peritoneal transport parameters were estimated using the three-pore model (3p model) and clinical data. Osmotic conductance for glucose was calculated from the parameters of the model.
  
  
  RESULTS
  D/P creatinine correlated with diffusive mass transport parameters for all considered solutes, but not with fluid transport characteristics. Hydraulic permeability (L(p)S) correlated with net ultrafiltration from miniPET, UFSP60, FWF60 and sodium dip. The fraction of ultrasmall pores correlated with FWF60 and sodium dip.
  
  
  CONCLUSIONS
  The sequential PET described and interpreted mechanisms of ultrafiltration and solute transport. Fluid transport parameters from the 3p model were independent of the PET D/P creatinine, but correlated with fluid transport characteristics from PET and miniPET.
authors: Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, 02-109 Warsaw, Poland.
authors: Magda
authors: M
authors: Galach
authors: Stefan
authors: S
authors: Antosiewicz
authors: Daniel
authors: D
authors: Baczynski
authors: Zofia
authors: Z
authors: Wankowicz
authors: Jacek
authors: J
authors: Waniewski
mesh_terms: D000328:Adult; D000368:Aged; D001692:Biological Transport / Q000502:physiology; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010537:Peritoneum / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000628:therapy; D013673:Technology Assessment, Biomedical / Q000379:methods*; D014462:Ultrafiltration
chemical_list: D005947:Glucose