title: A synthetic nanomaterial for virus recognition produced by surface imprinting.
abstract: Major stumbling blocks in the production of fully synthetic materials designed to feature virus recognition properties are that the target is large and its self-assembled architecture is fragile. Here we describe a synthetic strategy to produce organic/inorganic nanoparticulate hybrids that recognize non-enveloped icosahedral viruses in water at concentrations down to the picomolar range. We demonstrate that these systems bind a virus that, in turn, acts as a template during the nanomaterial synthesis. These virus imprinted particles then display remarkable selectivity and affinity. The reported method, which is based on surface imprinting using silica nanoparticles that act as a carrier material and organosilanes serving as biomimetic building blocks, goes beyond simple shape imprinting. We demonstrate the formation of a chemical imprint, comparable to the formation of biosilica, due to the template effect of the virion surface on the synthesis of the recognition material.
authors: School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Gründenstrasse 40, Muttenz CH-4132, Switzerland.
authors: Alessandro
authors: A
authors: Cumbo
authors: Bernard
authors: B
authors: Lorber
authors: Philippe F-X
authors: PF
authors: Corvini
authors: Wolfgang
authors: W
authors: Meier
authors: Patrick
authors: P
authors: Shahgaldian
mesh_terms: D001667:Binding, Competitive; D003102:Colloids; D007700:Kinetics; D054802:Molecular Imprinting / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties; D017864:Tombusvirus / Q000737:chemistry / Q000648:ultrastructure; D017806:Tymovirus / Q000737:chemistry / Q000648:ultrastructure; D014771:Virion / Q000737:chemistry / Q000648:ultrastructure; D014780:Viruses / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D003102:Colloids; D012822:Silicon Dioxide