title: Positive effects of zinc supplementation on growth, GH, IGF1, and IGFBP3 in eutrophic children.
abstract: Zinc is an essential micronutrient for growth and development. Its deficiency causes growth retardation in children and adolescents. The present study analyzes the effect of zinc on growth hormone (GH) secretion, insulin-like growth factor 1 (IGF1), and insulin-like growth factor-binding protein 3 (IGFBP3) in normal children before puberty. Thirty normal children were studied, 15 boys and 15 girls, aged 6-9 years. They were orally supplemented with 5 mg Zn/day for 3 months and 0.06537 mg Zn/kg body weight was injected before and after oral supplementation. Dietary intake and anthropometric measurements were assessed at baseline and end of study. Plasma GH levels increased during intravenous zinc administration and IGF1 and IGFBP3 increased after oral zinc supplementation. There was a positive correlation between the areas under the curves of GH and zinc after oral supplementation. Zinc supplementation was possibly effective in improving the body zinc status of the children, secretory levels of IGF1 and IGFBP3, GH potentialization, and height.
authors: Federal University of Rio Grande do Norte, Natal, Brazil.
authors: Camila Xavier
authors: CX
authors: Alves
authors: Sancha Helena Lima
authors: SH
authors: Vale
authors: Marcia Marilia Gomes
authors: MM
authors: Dantas
authors: Andrea Albuquerque
authors: AA
authors: Maia
authors: Mardone Cavalcante
authors: MC
authors: Franca
authors: Julio Sergio
authors: JS
authors: Marchini
authors: Lucia Dantas
authors: LD
authors: Leite
authors: Jose
authors: J
authors: Brandao-Neto
mesh_terms: D001827:Body Height; D002648:Child; D019587:Dietary Supplements; D005260:Female; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D015032:Zinc / Q000008:administration & dosage* / Q000097:blood
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D015032:Zinc