title: Bioavailability of phytochemicals and its enhancement by drug delivery systems.
abstract: Issues of poor oral bioavailability of cancer chemopreventives have hindered progress in cancer prevention. Novel delivery systems that modulate the pharmacokinetics of existing drugs, such as nanoparticles, cyclodextrins, niosomes, liposomes and implants, could be used to enhance the delivery of chemopreventive agents to target sites. The development of new approaches in prevention and treatment of cancer could encompass new delivery systems for approved and newly investigated compounds. In this review, we discuss some of the delivery approaches that have already made an impact by either delivering a drug to target tissue or increasing its bioavailability by many fold.
authors: James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, United States.
authors: Farrukh
authors: F
authors: Aqil
authors: James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, United States.
authors: Radha
authors: R
authors: Munagala
authors: James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, United States.
authors: Jeyaprakash
authors: J
authors: Jeyabalan
authors: James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, United States. Electronic address: mvvadh01@louisville.edu.
authors: Manicka V
authors: MV
authors: Vadhanam
mesh_terms: D016588:Anticarcinogenic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001682:Biological Availability; D003505:Cyclodextrins / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008081:Liposomes; D008823:Micelles; D053758:Nanoparticles; D064209:Phytochemicals / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D016588:Anticarcinogenic Agents; D003505:Cyclodextrins; D008081:Liposomes; D008823:Micelles; D064209:Phytochemicals