title: Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences.
abstract: Neutrophils are essential effector cells in the host defense against invading pathogens. Recently, novel neutrophil functions have emerged in addition to their classical anti-microbial role. One of these functions is the suppression of T cell responses. In this respect, neutrophils share similarities with granulocytic myeloid-derived suppressor cells (G-MDSCs). In this review, we will discuss the similarities and differences between neutrophils and G-MDSCs. Various types of G-MDSCs have been described, ranging from immature to mature cells shaping the immune response by different immune suppressive mechanisms. However, all types of G-MDSCs share distinct features of neutrophils, such as surface markers and morphology. We propose that G-MDSCs are heterogeneous and represent novel phenotypes of neutrophils, capable of suppressing the immune response. In this review, we will attempt to clarify the differences and similarities between neutrophils and G-MDSCs and attempt to facilitate further research.
authors: Department of Respiratory Medicine, University Medical Center Utrecht, HP. E 03.511, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
authors: Janesh
authors: J
authors: Pillay
authors: Tamar
authors: T
authors: Tak
authors: Vera M
authors: VM
authors: Kamp
authors: Leo
authors: L
authors: Koenderman
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D006098:Granulocytes / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D054992:Immunological Synapses; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D018375:Neutrophil Activation; D009504:Neutrophils / Q000276:immunology*; D010641:Phenotype; D017382:Reactive Oxygen Species / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000276:immunology
chemical_list: D017382:Reactive Oxygen Species