title: Adult Onset Still's Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations.
abstract: Adult-onset Still's disease is an inflammatory multisystemic disease of unknown etiology. Pleuritis is the most common pulmonary manifestation and pleural effusions are usually exudates with a predominance of neutrophils. We report a case of an eosinophilic pleural effusion as a novel and hitherto unrecognized manifestation of active adult-onset Still's disease. We also observed a marked NLRP3 inflammasome activation with increased production of IL-1β which coincided with the development and resolved upon remission of the pleural effusion suggesting a possible novel pathogenetic pathway for the development of pleural effusions in the context of the auto-inflammatory disorders.
authors: Interstitial Lung Disease Unit, Thoracic Medicine Department, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
authors: Katerina M
authors: KM
authors: Antoniou
authors: George A
authors: GA
authors: Margaritopoulos
authors: Ioannis
authors: I
authors: Giannarakis
authors: Christianna
authors: C
authors: Choulaki
authors: Nikos
authors: N
authors: Fountoulakis
authors: Nikos M
authors: NM
authors: Siafakas
authors: Prodromos
authors: P
authors: Sidiropoulos