title: Highly selective and sensitive analysis of dopamine by molecularly imprinted stir bar sorptive extraction technique coupled with complementary molecularly imprinted polymer sensor.
abstract: This paper reports a combination of molecularly imprinted stir bar sorptive extraction and complementary molecularly imprinted polymer-sensor for the analysis of dopamine as a biomarker of several neurodegenerative diseases occurred at ultra trace level. This exploited iniferter initiated polymerization via "surface grafting-from" approach onto magnetic stir bar (for sorptive extraction) and multiwalled carbon nanotubes-ceramic electrode (for detection). Such hyphenation helped dual pre-concentration of dopamine in aqueous, biological and pharmaceutical samples. This enabled high sensitivity to achieve the stringent limit [limit of detection: 4.9ngL(-1), RSD=2.4%, S/N=3, cerebrospinal fluid] of clinical detection, without any problems of non-specific contributions and cross-reactivity.
authors: Analytical Division, Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, India. prof.bbpd@yahoo.com
authors: Bhim Bali
authors: BB
authors: Prasad
authors: Amrita
authors: A
authors: Srivastava
authors: Mahavir Prasad
authors: MP
authors: Tiwari
mesh_terms: D000327:Adsorption; D002516:Ceramics; D004298:Dopamine / Q000032:analysis* / Q000134:cerebrospinal fluid; D004566:Electrodes; D057230:Limit of Detection; D054802:Molecular Imprinting / Q000295:instrumentation*; D037742:Nanotubes, Carbon; D011108:Polymers
chemical_list: D037742:Nanotubes, Carbon; D011108:Polymers; D004298:Dopamine