title: Anti-HepG-2 cell properties of rare earth tungstosilicic polyoxometalates containing 5-fluorouracil.
abstract: Two novel rare earth tungstosilicic polyoxometalate containing 5-fluorouracil, K26 (C4 H4 FN2O2)8Pr (SiW11 O39)4 x 10H2O (FPSW) and K26(C4H4FN2O2)8Sm(SiW11O39)4 x 9H2O (FSSW), were synthesized and their structure were characterized by using elemental analysis, FTIR spectra, X-ray powder diffraction and TG. The antitumor activity tests of the compounds FPSW and FSSW were carried out by the methyl thiazolyl tetrazolium method in hepatocellular carcinoma cell HepG-2. The results showed that FPSW and FSSW could inhibit the HepG-2 cells in vitro significantly. The EC50 of FPSW and FSSW is 1.94 x 10(-5) and 1.32 x 10(-5) mol x L(-1) respectively. The therapeutic index of FPSW and FSSW is 0.76 and 1.58 respectively.
authors: College of Science, China Agricultural University, Beijing 100193, China.
authors: Xia
authors: X
authors: Liu
authors: Shuai-Shuai
authors: SS
authors: Wang
authors: Chang-Gen
authors: CG
authors: Feng
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D005472:Fluorouracil / Q000032:analysis* / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D008674:Metals, Rare Earth / Q000737:chemistry; D012824:Silicic Acid / Q000737:chemistry / Q000494:pharmacology*; D017973:Tungsten Compounds / Q000737:chemistry / Q000494:pharmacology*; D000099294:Polyoxometalates
chemical_list: D000970:Antineoplastic Agents; D005472:Fluorouracil; D008674:Metals, Rare Earth; D012824:Silicic Acid; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates