title: Radical scavenging activity and cytotoxicity of active quinic acid derivatives from Scorzonera divaricata roots.
abstract: Five new quinic acid derivatives and two known 3-O-feruloylquinic acids were isolated from the roots of Scorzonera divaricata Turcz. The new compounds were elucidated as (-)-1,4-di-O-feruloyl-3-O-dihydrocaffeoylquinic acid, (-)-1-O-feruloyl-4-O- dihydrocaffeoylquinic acid, (-)-3,5-di-O-feruloylquinic acid, (-)-1-O-feruloyl-3-O-dihydro- caffeoylquinic acid, and (-)-1-O-feruloyl-5-O-dihydrocaffeoylquinic acid based on extensive spectroscopic studies, including one- and two-dimensional NMR, HRESIMS, UV, and IR results. Five compounds were assessed for antioxidant activity by ABTS and DPPH radical-scavenging assays and for their cytotoxicity against HL-60 and Hep-G2 cell lines by the MTT assay. Three quinic acid derivatives exhibited strong antioxidant activity, with IC(50) values of 3.95, 5.87, and 7.45 μg/mL against ABTS(+) and 11.7, 13.6, and 50.1 μg/mL against DPPH(). (-)-1,4-Di-O-feruloyl-3-O-dihydrocaffeoylquinic acid also exhibited moderate activity against Hep-G2 cell lines with an IC(50) value of 14.6 μg/mL.
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors: Yong-Jin
authors: YJ
authors: Yang
authors: Xu
authors: X
authors: Liu
authors: Hong-Ru
authors: HR
authors: Wu
authors: Xiao-Feng
authors: XF
authors: He
authors: Yu-Rong
authors: YR
authors: Bi
authors: Ying
authors: Y
authors: Zhu
authors: Zhen-Ling
authors: ZL
authors: Liu
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000633:toxicity; D002460:Cell Line; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D011801:Quinic Acid / Q000737:chemistry* / Q000633:toxicity; D031186:Scorzonera / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D010936:Plant Extracts; D011801:Quinic Acid