title: DEAD-box helicases as integrators of RNA, nucleotide and protein binding.
abstract: DEAD-box helicases perform diverse cellular functions in virtually all steps of RNA metabolism from Bacteria to Humans. Although DEAD-box helicases share a highly conserved core domain, the enzymes catalyze a wide range of biochemical reactions. In addition to the well established RNA unwinding and corresponding ATPase activities, DEAD-box helicases promote duplex formation and displace proteins from RNA. They can also function as assembly platforms for larger ribonucleoprotein complexes, and as metabolite sensors. This review aims to provide a perspective on the diverse biochemical features of DEAD-box helicases and connections to structural information. We discuss these data in the context of a model that views the enzymes as integrators of RNA, nucleotide, and protein binding. This article is part of a Special Issue entitled: The Biology of RNA helicases - Modulation for life.
authors: Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.
authors: Andrea A
authors: AA
authors: Putnam
authors: Eckhard
authors: E
authors: Jankowsky
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D053487:DEAD-box RNA Helicases / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008322:Mammals; D008969:Molecular Sequence Data; D009711:Nucleotides / Q000235:genetics* / Q000378:metabolism*; D011485:Protein Binding; D012313:RNA / Q000235:genetics* / Q000378:metabolism*
chemical_list: D009711:Nucleotides; D012313:RNA; D053487:DEAD-box RNA Helicases