title: Quality control of elective surgery for drug-resistant epilepsy in a German reference centre--a long-term outcome study.
abstract: OBJECTIVE
  Resective epilepsy surgery is the recommended treatment for a well-defined group of patients with drug-resistant epilepsy. Long-term outcome studies are an appropriate quality control to assess the value of elective surgical procedures ethically and economically. This paper reports the long-term post-surgical follow-up of adult patients of the Kork Epilepsy Centre.
  
  
  METHODS
  Data collection was performed by means of a questionnaire to obtain updated information about postsurgical outcome, frequency and postsurgical seizure semiology in case of relapse, postsurgical use of antiepileptic drugs, social issues and satisfaction rates. We classified seizure outcome according to the ILAE surgery outcome scale (OC 1-OC 6).
  
  
  RESULTS
  Outcome data of 340 adult patients were obtained. Mean post-operative follow-up was 6.7 years (range 1.0-21.6 years). Seizure remission was 67% if comprising patients with postoperative auras only (OC 1+OC 2). Sixty-two per cent of patients were completely seizure free. The majority of patients (78%) underwent temporal lobe resections. Sixty-four per cent of these and 52% of the patients with extra-temporal resections became completely seizure-free (OC 1). Only 34% of the patients with negative MRI achieved complete seizure-freedom.
  
  
  CONCLUSIONS
  In line with others our huge cohort sample that covers decades of experience with epilepsy surgery revealed satisfying long-term outcome results. Best results were obtained in lesional temporal lobe epilepsy, least favourable results in MRI-negative epilepsy.
authors: Kork Epilepsy Centre, Kehl-Kork, Germany. astaack@epilepsiezentrum.de
authors: Anke M
authors: AM
authors: Staack
authors: Anne-Sophie
authors: AS
authors: Wendling
authors: Julia
authors: J
authors: Scholly
authors: Ilona
authors: I
authors: Wisniewski
authors: Christoph
authors: C
authors: Kurth
authors: Josef
authors: J
authors: Saar
authors: Karin
authors: K
authors: Mathews
authors: Frédéric
authors: F
authors: Bodin
authors: Susanne
authors: S
authors: Fauser
authors: Dirk-Matthias
authors: DM
authors: Altenmüller
authors: Thomas M
authors: TM
authors: Freiman
authors: Andreas
authors: A
authors: Schulze-Bonhage
authors: Josef
authors: J
authors: Zentner
authors: Gerhard
authors: G
authors: Reinshagen
authors: Bernhard J
authors: BJ
authors: Steinhoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D015331:Cohort Studies; D017558:Elective Surgical Procedures / Q000379:methods / Q000592:standards*; D004827:Epilepsy / Q000188:drug therapy* / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011786:Quality Control; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000927:Anticonvulsants