title: Comparison of oral and intravenous glucose tolerance test derived sensitivity and secretory indices in obese adolescents.
abstract: BACKGROUND
  Insulin resistance increases type 2 diabetes risk in obese adolescents. Thus, quantitative tools measuring insulin sensitivity and secretion are important for risk assessment.
  
  
  METHODS
  Forty-four obese pubertal adolescents underwent oral glucose tolerance test (OGTT) and frequently sampled intravenous glucose tolerance test (FSIGT). We correlated OGTT-derived whole body sensitivity index (WBISI) with FSIGT-derived insulin sensitivity index (Si). Insulinogenic index (IGI) from OGTT was compared with acute insulin response to glucose (AIRg) from FSIGT.
  
  
  RESULTS
  Fasting insulin (r = -.64, P < .0005) and glucose (r = -.39 P ≤ .0005) predicted Si. The OGTT-derived index WBISI correlated with the FSIGT-derived Si (r = .608, P < .0005). IGI correlated with AIRg from FSIGT (r = .704, P < .0005).
  
  
  CONCLUSIONS
  OGTT-based measures correlated with FSIGT-derived measures of insulin sensitivity and secretion. In particular, we demonstrated that WBISI can be a reliable alternative to FSIGT-derived Si in clinical settings where OGTT is a more feasible option.
authors: Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA. Preneet.brar@nyumc.org
authors: Preneet C
authors: PC
authors: Brar
authors: Dorit
authors: D
authors: Koren
authors: Paul R
authors: PR
authors: Gallagher
authors: Bhavana
authors: B
authors: Pendurthi
authors: Lorraine E Levitt
authors: LE
authors: Katz
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D003430:Cross-Sectional Studies; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D000078790:Insulin Secretion; D008297:Male; D009765:Obesity / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D007328:Insulin