title: A novel polynuclear Cu(I)-sulfur cluster with 1,2-dithiolate-o-carborane ligands as a potential in vitro antitumour agent and its DNA binding properties.
abstract: A novel polynuclear Cu(I)-sulfur cluster, (C54H62B30Cu6N8S6), bearing 1,2-dithiolate-o-carborane and 1,10-phenanthroline ligands was synthesized. The complex displayed rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells and efficient CT-DNA binding.
authors: Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, PR China.
authors: Zhong
authors: Z
authors: Han
authors: Jin
authors: J
authors: Jiang
authors: Jing
authors: J
authors: Lu
authors: Dacheng
authors: D
authors: Li
authors: Shuang
authors: S
authors: Cheng
authors: Jianmin
authors: J
authors: Dou
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D001880:Boranes / Q000737:chemistry*; D018938:Caco-2 Cells; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D008024:Ligands; D008968:Molecular Conformation; D010618:Phenanthrolines / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001880:Boranes; D056831:Coordination Complexes; D008024:Ligands; D010618:Phenanthrolines; D013455:Sulfur; D003300:Copper; D004247:DNA; C025205:1,10-phenanthroline