title: Takayasu arteritis in a 4-year-old girl: case report and brief overview of the pediatric literature.
abstract: Takayasu arteritis (TA) is a large vessel vasculitis that involves the aorta, its major branches and pulmonary arteries. Diagnosis of TA during childhood remains challenging due to the non-specific symptoms. We report a four-year-old girl presenting with fever, fatigue, weight loss, and elbow pain who was later diagnosed as childhood TA. On admission, she had fever, hypertension, decreased pulses, bruits, hepatosplenomegaly, and increased erythrocyte sedimentation rate and C-reactive protein level. Computed tomography angiography showed luminal narrowing and wall thickening in ascending aorta, brachiocephalic, left common carotid and left vertebral arteries and descending aorta. Oral corticosteroid (prednisone, 2 mg/kg/day) was instituted, later followed by oral methotrexate (12.5 mg/m2/week). TA is rare in children; however, childhood TA must be considered in children who present with non-specific systemic symptoms, hypertension and increased acute phase reactants.
authors: Department of Pediatric Cardiology, Konya Training and Research Hospital, Turkey. ebruaypar@gmail.com
authors: Ebru
authors: E
authors: Aypar
authors: Ash
authors: A
authors: Celebi-Tayfur
authors: Melike
authors: M
authors: Keser
authors: Dursun
authors: D
authors: Odabaş
authors: Fatih
authors: F
authors: Ozaltin
authors: Yahya
authors: Y
authors: Paksoy
authors: Seza
authors: S
authors: Ozen
mesh_terms: D000284:Administration, Oral; D000792:Angiography; D002097:C-Reactive Protein / Q000378:metabolism*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D013625:Takayasu Arteritis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D002097:C-Reactive Protein