title: Panel reactive antibody monitoring in pediatric patients undergoing ventricle assist device as a bridge to heart transplantation.
abstract: We describe the incidence and patterns of anti-human leukocyte antigens antibody production in a pediatric population undergoing ventricular assist device (VAD) implantation. Serial panel reactive antibody was obtained prior to VAD implant, during VAD support, and after orthotopic heart transplantation (OHT). Seven children (median age 15 months) underwent VAD support as bridge to OHT. Posttransplant sensitization occurred in 42% of VAD patients and in 14% during VAD support.
authors: Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Pediatric Hospital, IRCCS, Rome, Italy. grutter@opbg.net
authors: Giorgia
authors: G
authors: Grutter
authors: Antonio
authors: A
authors: Amodeo
authors: Gianluca
authors: G
authors: Brancaccio
authors: Francesco
authors: F
authors: Parisi
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005858:Germany; D006680:HLA Antigens / Q000276:immunology*; D006333:Heart Failure / Q000097:blood / Q000276:immunology / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D016027:Heart Transplantation / Q000009:adverse effects / Q000276:immunology*; D006353:Heart-Assist Devices; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D011474:Prosthesis Design; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left; D014850:Waiting Lists
chemical_list: D001323:Autoantibodies; D006680:HLA Antigens; D007518:Isoantibodies