title: Case report: a successful pregnancy outcome in a patient with non-mosaic Turner syndrome (45, X) via in vitro fertilization.
abstract: We describe a successful pregnancy outcome in a patient with non-mosaic Turner syndrome (45, X) via in vitro fertilization. The patient achieved a second pregnancy at 35 years of age. The her blood lymphocyte karyotype was examined by G-band and FISH. Furthermore, cumulus cells and her elbow skin cells were evaluated via FISH. Non-mosaic Turner syndrome was determined by G-banding [100 % (50/50) 45, X]. Lymphocytes were shown as 478/500 (95.6 %) cells of X sex chromosome signal, 15/500 (3.0 %) cells of XXX signal, and 7/500 (1.4 %) cells of XX signal. The cumulus cells were mosaic: 152/260 (58.5 %) were X; 84/260 (32.3 %) were XXX, 20/260 (7.7 %) were XX, and 4/260 (1.5 %) were XY. Moreover, skin cells included a mosaic karyotype [47, XXX(29)/46, XX(1)]. We conclude that the collection of a large number of blood lymphocytes can reveal different mosaic patterns (X, XX and XXX) by FISH in spite of non-mosaic Turner syndrome.
authors: Iwaki Women's Clinic, 3-2 Ookishita, Uchigo, Iwaki, Fukushima, 973-8403, Japan. sugawara@iwaki-fu.or.jp
authors: Nobuo
authors: N
authors: Sugawara
authors: Yasuyuki
authors: Y
authors: Kimura
authors: Yasuhisa
authors: Y
authors: Araki
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D059785:Karyotype; D008297:Male; D009030:Mosaicism; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012730:Sex Chromosomes / Q000235:genetics; D014424:Turner Syndrome / Q000235:genetics