title: A review on JC virus infection in kidney transplant recipients.
abstract: The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as progressive multifocal leukoencephalopathy (PML). Although the reactivation of another human PyV, BK virus (BKV), is relatively common and its association with the polyomavirus associated nephropathy (PyVAN) following renal transplantation is proven, JCV replication and its impact on graft function and survival are less well studied. Here we describe the biology of JCV and its pathological features and we review the literature regarding the JCV infection analyzed in the setting of transplantations.
authors: Laboratory of Translational Research, Health Science Foundation "Ettore Sansavini", Corso Garibaldi 11, 48022 Lugo, Italy.
authors: Serena
authors: S
authors: Delbue
authors: Mariano
authors: M
authors: Ferraresso
authors: Luciana
authors: L
authors: Ghio
authors: Camilla
authors: C
authors: Carloni
authors: Silvia
authors: S
authors: Carluccio
authors: Mirco
authors: M
authors: Belingheri
authors: Alberto
authors: A
authors: Edefonti
authors: Pasquale
authors: P
authors: Ferrante
mesh_terms: D000818:Animals; D058070:Asymptomatic Diseases; D006084:Graft Rejection / Q000209:etiology / Q000821:virology*; D006801:Humans; D016867:Immunocompromised Host; D007577:JC Virus / Q000502:physiology*; D007668:Kidney / Q000473:pathology / Q000821:virology; D016030:Kidney Transplantation; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology / Q000821:virology*; D027601:Polyomavirus Infections / Q000150:complications / Q000276:immunology*; D011183:Postoperative Complications / Q000821:virology*; D014181:Transplantation Immunology; D014412:Tumor Virus Infections / Q000150:complications / Q000276:immunology*; D017735:Virus Latency