title: Prevalence of pilomatricoma in Turner syndrome: findings from a multicenter study.
abstract: OBJECTIVE
  The absence of data on the prevalence of pilomatricoma among patients with Turner syndrome served as the catalyst for this multicenter investigation.
  
  
  OBJECTIVE
  To ascertain the prevalence of pilomatricoma among patients with Turner syndrome and to determine any association between the development of pilomatricomas and the use of exogenous hormones in patients with Turner syndrome.
  
  
  METHODS
  A retrospective medical record review from January 1, 2000, through January 1, 2010, was performed of all patients with Turner syndrome. Data on pilomatricomas and the use of hormone therapy were collected.
  
  
  METHODS
  University of California-Davis Medical Center, University of Nebraska Medical Center, and The University of North Carolina at Chapel Hill.
  
  
  METHODS
  Patients with a diagnosis of Turner syndrome.
  
  
  METHODS
  Prevalence of concomitant pilomatricoma and diagnosis of Turner syndrome. Secondary outcome measures included the use of the exogenous hormones estrogen or recombinant human growth hormone (rhGH).
  
  
  RESULTS
  In total, 311 patients with Turner syndrome were identified from these 3 institutions. Among them, 8 patients (2.6%) were diagnosed as having pilomatricomas. Before the development of pilomatricomas, 5 patients had been treated with rhGH but not estrogen, 1 patient had received estrogen but not rhGH, and 2 patients did not receive either therapy.
  
  
  CONCLUSIONS
  Although the prevalence of pilomatricoma among the general population is unknown, this study demonstrates a high prevalence (2.6%) of pilomatricomas among patients with Turner syndrome. No apparent relationship was noted among our patients or in the literature between the use of rhGH and the development of pilomatricomas.
authors: Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida, USA. zac0@aol.com
authors: Marc Z
authors: MZ
authors: Handler
authors: Kristina M
authors: KM
authors: Derrick
authors: Richard E
authors: RE
authors: Lutz
authors: Dean S
authors: DS
authors: Morrell
authors: Marsha L
authors: ML
authors: Davenport
authors: April W
authors: AW
authors: Armstrong
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006201:Hair Diseases / Q000453:epidemiology*; D019382:Human Growth Hormone / Q000009:adverse effects; D006801:Humans; D018296:Pilomatrixoma / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000453:epidemiology*; D014424:Turner Syndrome / Q000188:drug therapy / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D004967:Estrogens; D019382:Human Growth Hormone