title: Tooth extractions in intravenous bisphosphonate-treated patients: a refined protocol.
abstract: OBJECTIVE
  The aim of this prospective hospital-based study was to refine a surgical protocol for tooth extractions in patients with a history of intravenous use of a potent bisphosphonate by modifying a previously reported protocol to produce a significantly shortened operating time.
  
  
  METHODS
  Prospective patients with a follow-up of at least 4 months were included. Tooth extractions were performed without a vestibular split-thickness flap; healing was stimulated by filling the extraction site with autologous plasma rich in growth factors (PRGF System, BTI Biotechnology Institute, Vitoria, Spain). Local and systemic infection control was obtained with dental hygiene and antibiotic therapy.
  
  
  RESULTS
  Sixty-three patients participated in the study. Two hundred two tooth extractions were performed. Differences between the present and previous protocols (the previous protocol used a vestibular flap) were analyzed and the surgical time proved significantly shorter for the present approach (P = .00).
  
  
  CONCLUSIONS
  The proposed surgical protocol appears to be a better choice for patients treated with intravenous bisphosphonates who need tooth extraction, because it seems to be faster and simpler than the previously reported successful protocol.
authors: Oral Surgery Section, Department of Biomedical Science and Human Oncology, University of Turin, Turin, Italy.
authors: Matteo
authors: M
authors: Scoletta
authors: Valentina
authors: V
authors: Arata
authors: Paolo G
authors: PG
authors: Arduino
authors: Ennio
authors: E
authors: Lerda
authors: Andrea
authors: A
authors: Chiecchio
authors: Giorgia
authors: G
authors: Gallesio
authors: Crispian
authors: C
authors: Scully
authors: Marco
authors: M
authors: Mozzati
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000517:prevention & control*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D004164:Diphosphonates / Q000008:administration & dosage*; D005260:Female; D006133:Growth Substances / Q000097:blood; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D061646:Operative Time; D011446:Prospective Studies; D014081:Tooth Extraction / Q000379:methods*
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D006133:Growth Substances