title: Protective role of L-carnitine and vitamin E on the testis of atherosclerotic rats.
abstract: Atherosclerosis is a condition caused by lipid build-up and inflammation in the arteries, so hyperlipidemia is the major reason for atherosclerosis. Testis was found to be negatively affected by hyperlipidemia which leads to its impaired functions. Vitamin E and l-carnitine have well-known lipid-lowering and antioxidative activities. Triton WR 1339 is a non-ionic detergent, which induces severe hyperlipidemia by inhibition of lipoprotein lipase. The present study evaluates the protective role of vitamin E and l-carnitine on the testis in atherosclerosis and detects the most effective choice for protection against atherosclerosis; vitamin E, l-carnitine or a combination of both. A total of 80 albino male rats were divided into eight groups (10 rats for each group): control (G1), triton (G2), l-carnitine (G3), triton + l-carnitine (G4), vitamin E (G5), triton + vitamin E (G6), l-carnitine + vitamin E (G7) and triton + l-carnitine + vitamin E (G8). Data showed a significant increase in the levels of total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), 17 beta hydroxysteroid dehydrogenase (17 β HSD), testicular catalase and malondialdehyde (MDA) in G2 when compared with G1, whereas high-density lipoprotein cholesterol (HDL-C), serum testosterone, testicular 17 ketosteroid reductase (17 KSR), total thiol and glutathione-S-transferase (GST) data showed a significant decrease in G2 when compared with G1. Treatment with l-carnitine or/and vitamin E helps in improving the adverse effect of triton; also the histological changes confirm this finding. So the present study recommends all people to include l-carnitine and vitamin E in their diet to be protected against atherosclerosis.
authors: Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.
authors: Afrah F
authors: AF
authors: Salama
authors: Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt.
authors: Safwat M
authors: SM
authors: Kasem
authors: Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt Department of Chemistry, Tanta University, Tanta, Egypt toussonehab@yahoo.com.
authors: Ehab
authors: E
authors: Tousson
authors: Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.
authors: Mohammed K H
authors: MK
authors: Elsisy
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000097:blood / Q000378:metabolism; D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D002340:Carotid Artery Diseases / Q000188:drug therapy / Q000517:prevention & control*; D002374:Catalase / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D014810:Vitamin E; D013739:Testosterone; D008315:Malondialdehyde; D015067:17-Hydroxysteroid Dehydrogenases; D002374:Catalase; D005982:Glutathione Transferase; D002331:Carnitine
keywords: Testes; atherosclerotic l-carnitine; lipid profile; oxidative stress; triton; vitamin E