title: Expression profiles analysis of pancreatic cancer.
abstract: BACKGROUND
  [Corrected] Pancreatic cancer is the fourth most common cause of cancer-related deaths across the globe and has a poor prognosis.
  
  
  OBJECTIVE
  To investigate the characteristics of genomic expression profiles of pancreatic cancer and screen differentially expressed genes.
  
  
  METHODS
  Using GSE16515 dataset downloaded from GEO (Gene Expression Omnibus) database, we first screened the differentially expressed genes (DEGs) in pancreatic cancer by packages in R language. The key functions of DEGs were investigated by GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis. The potential functionally important SNP (Single Nucleotide Polymorphism) was selected from the dbSNP database.
  
  
  RESULTS
  A total of 1270 DEGs were identified. Most of them were predicted to be involved in pancreatic cancer development by sequence variant. Six genes (CDC42, STAT1, RALA, BCL2L1, TGFA, and EGF) were enriched in the known pancreatic cancer pathway. All these six genes had SNP, usually mutation at A/G and C/T point.
  
  
  CONCLUSIONS
  Our results provide some underlying biomarkers for early diagnosis of pancreatic cancer.
authors: Department of Gastrointestinal Surgery, Shanghai Changzheng Hospital affiliated to the Second Military Medical University, Shanghai, China.
authors: D
authors: D
authors: Yang
authors: Z
authors: Z
authors: Zhu
authors: W
authors: W
authors: Wang
authors: P
authors: P
authors: Shen
authors: Z
authors: Z
authors: Wei
authors: C
authors: C
authors: Wang
authors: Q
authors: Q
authors: Cai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D030541:Databases, Genetic; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D023281:Genomics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide
chemical_list: D014408:Biomarkers, Tumor