title: Peptide directed transmembrane transport and nuclear localization of Ru(II) polypyridyl complexes in mammalian cells.
abstract: The targeted delivery of luminescent Ru(II) polypyridyl complexes to the nucleus of live mammalian cells by a Nuclear Localisation Signal (NLS) peptide; NF-κB is demonstrated.
authors: National Centre for Sensor Research, School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
authors: Lorraine
authors: L
authors: Blackmore
authors: Roisin
authors: R
authors: Moriarty
authors: Ciaran
authors: C
authors: Dolan
authors: Kellie
authors: K
authors: Adamson
authors: Robert J
authors: RJ
authors: Forster
authors: Marc
authors: M
authors: Devocelle
authors: Tia E
authors: TE
authors: Keyes
mesh_terms: D000818:Animals; D016466:CHO Cells; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D049449:Luminescence; D015394:Molecular Structure; D016328:NF-kappa B / Q000378:metabolism; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
chemical_list: D016328:NF-kappa B; D009942:Organometallic Compounds; D010455:Peptides; D012428:Ruthenium