title: The efficacy of Irvingia gabonensis supplementation in the management of overweight and obesity: a systematic review of randomized controlled trials.
abstract: The aim of this systematic review was to evaluate the evidence from randomized controlled trials (RCTs) involving the use of the African Bush Mango, Irvingia gabonensis for body weight reduction in obese and overweight individuals. Electronic and nonelectronic searches were conducted to identify relevant RCTs. The bibliographies of located articles were also searched. No age, gender, or language restrictions were imposed. The reporting quality of identified RCTs was assessed using a methodological checklist adapted from the Consolidated Standard of Reporting Trials Statement and Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Two reviewers independently determined eligibility and assessed the reporting quality of included studies. Three RCTs were identified, and all were included. The RCTs all had flaws in the reporting of their methodology. All RCTs reported statistically significant reductions in body weight and waist circumference favoring I. gabonensis over placebo. The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile. Adverse events included headache and sleep difficulty. Due to the paucity and poor reporting quality of the RCTs, the effect of I. gabonensis on body weight and related parameters are unproven. Therefore, I. gabonensis cannot be recommended as a weight loss aid. Future research in this area should be more rigorous and better reported.
authors: Complementary Medicine, Peninsula Medical School, University of Exeter, Exeter, United Kingdom. igho.onakpoya@pcmd.ac.uk
authors: Igho
authors: I
authors: Onakpoya
authors: Lucy
authors: L
authors: Davies
authors: Paul
authors: P
authors: Posadzki
authors: Edzard
authors: E
authors: Ernst
mesh_terms: D002482:Cellulose / Q000009:adverse effects; D019587:Dietary Supplements; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008055:Lipids / Q000097:blood*; D009765:Obesity / Q000188:drug therapy*; D050177:Overweight; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced; D055105:Waist Circumference / Q000187:drug effects*; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D008055:Lipids; D010936:Plant Extracts; C051375:dikanut; D002482:Cellulose