title: Gut-liver axis and microbiota in NAFLD: insight pathophysiology for novel therapeutic target.
abstract: There is increasing evidence for a correlation between intestinal microbiota, bacterial translocation and hepatic steatosis. Intestinal microbiota affects nutrient absorption and energy homeostasis. Altered intestinal permeability may favor the passage of bacteriaderived compounds into systemic circulation, causing a systemic inflammatory state, characteristic of the metabolic syndrome. The interaction between intestinal permeability and luminal bacteria is involved in the pathogenesis and evolution of non-alcoholic liver disease. Microbiota pharmacological modulation could be a promising tool for a new therapeutical approach to non-alcoholic fatty liver disease.
authors: Institute of Internal Medicine, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy. luca.miele@rm.unicatt.it
authors: Luca
authors: L
authors: Miele
authors: Giuseppe
authors: G
authors: Marrone
authors: Cristiano
authors: C
authors: Lauritano
authors: Consuelo
authors: C
authors: Cefalo
authors: Antonio
authors: A
authors: Gasbarrini
authors: Chris
authors: C
authors: Day
authors: Antonio
authors: A
authors: Grieco
mesh_terms: D005234:Fatty Liver / Q000382:microbiology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008099:Liver / Q000382:microbiology*; D065626:Non-alcoholic Fatty Liver Disease; D010539:Permeability