title: Iron and zinc bioavailability in Caco-2 cells: influence of caseinophosphopeptides.
abstract: A study has been made of the influence of two pools of caseinophosphopeptides (CPPs) obtained from α(s)- and β-casein (CN) fractions, and of three specific CPPs (β-CN(1-25)4P, α(s1)-CN(64-74)4P and α(s2)-CN(1-19)4P), on iron bioavailability (ferritin synthesis) and zinc bioavailability (retention, transport and uptake of zinc) in Caco-2 cells. α-CPP and β-CPP pools did not improve ferritin synthesis, but the three specific CPPs showed an increase in ferritin synthesis in Caco-2 cells versus iron sulphate, β-CN(1-25)4P being the most effective. In relation to zinc bioavailability, α-CPPs, β-CPPs, α(s1)-CN(64-74)4P and β-CN(1-25)4P increased zinc uptake. However, this increase was of the same order as the increase due to the presence of zinc sulphate.
authors: Nutrition and Food Chemistry, Faculty of Pharmacy, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.
authors: María José
authors: MJ
authors: García-Nebot
authors: Reyes
authors: R
authors: Barberá
authors: Amparo
authors: A
authors: Alegría
mesh_terms: D001682:Biological Availability; D001692:Biological Transport; D018938:Caco-2 Cells; D002364:Caseins / Q000378:metabolism*; D005293:Ferritins / Q000096:biosynthesis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
chemical_list: D002364:Caseins; D010446:Peptide Fragments; C412562:caseinophosphopeptide 1-25; D005293:Ferritins; D007501:Iron; D015032:Zinc