title: Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population.
abstract: This  study aimed to investigate the potential association of TYK2 and STAT3 genes with the susceptibility to Crohn's disease (CD) among Malaysians. DNA  samples were obtained from 80 CD patients and 100 healthy controls. Polymerase  chain reaction-restriction fragment length polymorphism methods were employed  for genotyping, followed by statistical analysis. In our current study, none of  the single nucleotide polymorphisms of either TYK2 or STAT3 was  statistically associated with the susceptibility to CD in our local population  (P > 0.05). In contrast, there was a statistically significant association  between the G/G homozygotes of the STAT3 rs2293152 and the healthy  control group (χ(2) = 6.229, P <  0.05). In conclusion, our study does not support the role of the TYK2 and STAT3 genes influencing CD susceptibility.
authors: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors: L H
authors: LH
authors: Lian
authors: T P
authors: TP
authors: Lau
authors: V L
authors: VL
authors: Lee
authors: W S
authors: WS
authors: Lee
authors: I
authors: I
authors: Hilmi
authors: K L
authors: KL
authors: Goh
authors: K H
authors: KH
authors: Chua
mesh_terms: D044466:Asian People / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008296:Malaysia; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D050796:STAT3 Transcription Factor / Q000235:genetics*; D053634:TYK2 Kinase / Q000235:genetics*
chemical_list: D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D053634:TYK2 Kinase; C070139:TYK2 protein, human