title: Identifying the boundaries of retinal pigment epithelial detachments using two spectral-domain optical coherence tomography instruments.
abstract: OBJECTIVE
  To compare two spectral-domain optical coherence tomography (SD-OCT) instruments in identifying the boundaries of retinal pigment epithelium detachment (PED).
  
  
  METHODS
  27 eyes were scanned with Cirrus and Spectralis SD-OCT instruments during a single visit. Two Cirrus scan patterns were used: the 512 × 128 and 200 × 200 covering a 6 × 6 mm (20° × 20°) area. The Spectralis scan pattern consisted of seven B-scans, averaged 51 times, covering a 30° × 5° area. The main outcome measures were the retinal thickness at the foveal center and the number of segmentation failures on the central B-scan.
  
  
  RESULTS
  The Spectralis algorithm failed to follow the proper retinal contour in 25 eyes (92.6%), while the segmentation on the Cirrus instrument was successful in every central B-scan. Spectralis yielded greater retinal thickness measurements in all cases, and the average difference between Cirrus and Spectralis was 139 μm (P < .001). The intraclass correlation coefficient between the two Cirrus scan patterns was 0.998, and Cirrus versus Spectralis was 0.21.
  
  
  CONCLUSIONS
  The Cirrus SD-OCT instrument identifies the appropriate segmentation boundaries in the presence PED. The Spectralis SD-OCT algorithm was unreliable in segmenting PEDs, leading to inaccurate retinal thickness measurements unless manual adjustments were performed.
authors: Bascom Palmer Eye Institute, 900 NW 17th St., Miami, FL 33136, USA. prosenfeld@med.miamiedu
authors: Fernando M
authors: FM
authors: Penha
authors: Giovanni
authors: G
authors: Gregori
authors: Zohar
authors: Z
authors: Yehoshua
authors: William J
authors: WJ
authors: Feuer
authors: Philip J
authors: PJ
authors: Rosenfeld
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012163:Retinal Detachment / Q000175:diagnosis*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*