title: [68Ga]-albumin-PET in the monitoring of left ventricular function in murine models of ischemic and dilated cardiomyopathy: comparison with cardiac MRI.
abstract: OBJECTIVE
  The purpose of this study is to evaluate left ventricular functional parameters in healthy mice and in different murine models of cardiomyopathy with the novel blood pool (BP) positron emission tomography (PET) tracer [68Ga]-albumin.
  
  
  METHODS
  ECG-gated microPET examinations were obtained in healthy mice, and mice with dilative (DCM) and ischemic cardiomyopathy (ICM) using the novel BP tracer [68Ga]-albumin (AlbBP), as well as [18F]-FDG microPET. Cine-magnetic resonance imaging (MRI) examination performed on a clinical 1.5-T MRI provided the reference standard measurements.
  
  
  RESULTS
  When considering the combined group of healthy controls, DCM and ICM AlbBP-PET significantly overestimated the magnitudes of EDV (AlbBP, 181±86 μl; cine-MRI, 125±80 μl; P<0.001) and ESV (AlbBP, 136±92 μl; cine-MRI, 96±77 μl; P<0.001), whereas the EF (AlbBP, 31±16%; cine-MRI, 33±21%; P=0.910) matched closely to cine-MRI results, as did findings with [18F]-FDG. High correlations were found between the measured cardiac parameters (EDV: R=0.978, ESV: R=0.989, and LVEF: R=0.992).
  
  
  CONCLUSIONS
  Measuring left ventricular function in mice with [68Ga]-albumin BP PET is feasible and showed a high correlation compared to cine-MRI, which was used as a reference standard.
authors: Department of Nuclear Medicine, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany.
authors: Andrei
authors: A
authors: Todica
authors: Stefan
authors: S
authors: Brunner
authors: Guido
authors: G
authors: Böning
authors: Sebastian
authors: S
authors: Lehner
authors: Stephan G
authors: SG
authors: Nekolla
authors: Moritz
authors: M
authors: Wildgruber
authors: Christopher
authors: C
authors: Übleis
authors: Carmen
authors: C
authors: Wängler
authors: Martina
authors: M
authors: Sauter
authors: Karin
authors: K
authors: Klingel
authors: Paul
authors: P
authors: Cumming
authors: Peter
authors: P
authors: Bartenstein
authors: Ralf
authors: R
authors: Schirrmacher
authors: Wolfgang Michael
authors: WM
authors: Franz
authors: Marcus
authors: M
authors: Hacker
mesh_terms: D000418:Albumins / Q000493:pharmacokinetics; D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004195:Disease Models, Animal; D019788:Fluorodeoxyglucose F18; D008279:Magnetic Resonance Imaging; D051379:Mice; D064847:Multimodal Imaging; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D049268:Positron-Emission Tomography; D014018:Tissue Distribution; D016277:Ventricular Function, Left
chemical_list: C586247:68Ga-albumin; D000418:Albumins; D019788:Fluorodeoxyglucose F18