title: Decaffeinated coffee prevents scopolamine-induced memory impairment in rats.
abstract: BACKGROUND
  Several human studies have reported that coffee consumption improves cognitive performance. In the present study, we investigated whether instant decaffeinated coffee also ameliorates cognitive performance and attenuates the detrimental effects of scopolamine on memory.
  
  
  METHODS
  Memory performance was evaluated in Morris water maze test and passive avoidance test. Instant decaffeinated coffee (p.o.) at 120 or 240 mg/kg in Sprague-Dawley rats, which is equivalent to approximately three or six cups of coffee, respectively, in a 60 kg human, was administered for two weeks.
  
  
  RESULTS
  Oral gavage administration of instant decaffeinated coffee inhibited scopolamine-induced memory impairment, which was measured by Morris water maze test and passive avoidance test. Instant decaffeinated coffee suppressed scopolamine-mediated elevation of tumor necrosis factor-α (TNF-α) and stimulation of nuclear factor-κB (NF-κB) pathway (i.e., phosphorylation of IκBα and p65) in the rat hippocampus.
  
  
  CONCLUSIONS
  These findings suggest that caffeine-free decaffeinated coffee may prevent memory impairment in human through the inhibition of NF-κB activation and subsequent TNF-α production.
authors: WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Republic of Korea.
authors: Young Jin
authors: YJ
authors: Jang
authors: Jiyoung
authors: J
authors: Kim
authors: Jaesung
authors: J
authors: Shim
authors: Chang-Yul
authors: CY
authors: Kim
authors: Jung-Hee
authors: JH
authors: Jang
authors: Ki Won
authors: KW
authors: Lee
authors: Hyong Joo
authors: HJ
authors: Lee
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D015153:Blotting, Western; D001923:Brain Chemistry / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003069:Coffee; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced* / Q000517:prevention & control* / Q000523:psychology; D018727:Muscarinic Antagonists; D016328:NF-kappa B / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000199:Actins; D000697:Central Nervous System Stimulants; D003069:Coffee; D018727:Muscarinic Antagonists; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D002110:Caffeine; D012601:Scopolamine