title: Design of stable β-sheet-based cyclic peptide assemblies assisted by metal coordination: selective homo- and heterodimer formation.
abstract: Metal-directed supramolecular construction represents one of the most powerful tools to prepare a large variety of structures and functions. The ability of metals to organize different numbers and types of ligands with a variety of geometries (linear, trigonal, octahedral, etc.) expands the supramolecular synthetic architecture. We describe here the precise construction of homo- and heterodimeric cyclic peptide entities through coordination of a metal (Pd, Au) and to β-sheet-type hydrogen-bonding interactions. The selective coordination properties of the appropriate metal allow control over the cross-strand interaction between the two-peptide strands.
authors: Departamento de Química Orgánica y Unidad Asociada al CSIC, Centro singular de investigación en Química Biológica y Materiales Moleculares (CIQUS), Campus Vida, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors: Michele
authors: M
authors: Panciera
authors: Manuel
authors: M
authors: Amorín
authors: Luis
authors: L
authors: Castedo
authors: Juan R
authors: JR
authors: Granja
mesh_terms: D006046:Gold / Q000737:chemistry*; D006860:Hydrogen Bonding; D008024:Ligands; D010165:Palladium / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D010456:Peptides, Cyclic; D010165:Palladium; D006046:Gold