title: Palladium(0)-catalyzed alkynylation of C(sp3)-H bonds.
abstract: The alkynylation of β-C(sp(3))-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyclic carbene (NHC) and Pd(0)/phosphine (PR3) catalysts. This is the first example of utilizing [AlkynylPd(II)L(n)] complexes to activate C(sp(3))-H bonds.
authors: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Jian
authors: J
authors: He
authors: Masayuki
authors: M
authors: Wasa
authors: Kelvin S L
authors: KS
authors: Chan
authors: Jin-Quan
authors: JQ
authors: Yu
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000577:Amides; D006846:Hydrocarbons, Halogenated; D009942:Organometallic Compounds; D010165:Palladium