title: Overlapping and segregated resting-state functional connectivity in patients with major depressive disorder with and without childhood neglect.
abstract: Many studies have suggested that childhood maltreatment increase risk of adulthood major depressive disorder (MDD) and predict its unfavorable treatment outcome, yet the neural underpinnings associated with childhood maltreatment in MDD remain poorly understood. Here, we seek to investigate the whole-brain functional connectivity patterns in MDD patients with childhood maltreatment. Resting-state functional magnetic resonance imaging was used to explore intrinsic or spontaneous functional connectivity networks of 18 MDD patients with childhood neglect, 20 MDD patients without childhood neglect, and 20 healthy controls. Whole-brain functional networks were constructed by measuring the temporal correlations of every pairs of brain voxels and were further analyzed by using graph-theory approaches. Relative to the healthy control group, the two MDD patient groups showed overlapping reduced functional connectivity strength in bilateral ventral medial prefrontal cortex/ventral anterior cingulate cortex. However, compared with MDD patients without a history of childhood maltreatment, those patients with such a history displayed widespread reduction of functional connectivity strength primarily in brain regions within the prefrontal-limbic-thalamic-cerebellar circuitry, and these reductions significantly correlated with measures of childhood neglect. Together, we showed that the MDD groups with and without childhood neglect exhibited overlapping and segregated functional connectivity patterns in the whole-brain networks, providing empirical evidence for the contribution of early life stress to the pathophysiology of MDD.
authors: Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors: Lifeng
authors: L
authors: Wang
authors: Zhengjia
authors: Z
authors: Dai
authors: Hongjun
authors: H
authors: Peng
authors: Liwen
authors: L
authors: Tan
authors: Yuqiang
authors: Y
authors: Ding
authors: Zhong
authors: Z
authors: He
authors: Yan
authors: Y
authors: Zhang
authors: Mingrui
authors: M
authors: Xia
authors: Zexuan
authors: Z
authors: Li
authors: Weihui
authors: W
authors: Li
authors: Yi
authors: Y
authors: Cai
authors: Shaojia
authors: S
authors: Lu
authors: Mei
authors: M
authors: Liao
authors: Li
authors: L
authors: Zhang
authors: Weiwei
authors: W
authors: Wu
authors: Yong
authors: Y
authors: He
authors: Lingjiang
authors: L
authors: Li
mesh_terms: D000328:Adult; D016477:Artifacts; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002648:Child; D002649:Child Abuse; D003865:Major Depressive Disorder / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D015203:Reproducibility of Results; D012146:Rest / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted
keywords: MDD; childhood maltreatment; connectome; functional connectivity; resting-state fMRI