title: A versatile C-H functionalization of tetrahydroisoquinolines catalyzed by iodine at aerobic conditions.
abstract: A versatile aerobic catalytic system (I(2) and O(2)/TBHP) for C-H functionalization is reported. This CDC (cross-dehydrogentive coupling) reaction is compatible with a large number of nucleophiles and is performed under ambient reaction conditions. The scope of the metal-free CDC is illustrated by synthesizing a variety of functionalized tetrahydroisoquinolines and N,N-dimethylaniline. The highlight of the method is a Friedel-Crafts reaction of phenols and indole with tertiary amines.
authors: Department of Organic Chemistry, Indian Institute of Science, Bangalore, Karnataka, India.
authors: Jayaraman
authors: J
authors: Dhineshkumar
authors: Manjunath
authors: M
authors: Lamani
authors: Kaliyamoorthy
authors: K
authors: Alagiri
authors: Kandikere Ramaiah
authors: KR
authors: Prabhu