title: Experimental study on anaphylaxis of qingkailing injection and its components on Beagle dogs.
abstract: OBJECTIVE
  To study the anaphylaxis of Qingkailing injection (QI) and its components.
  
  
  METHODS
  Experimental anaphylactoid and allergic reactions were used. Changes in the behaviors of Beagles and serum levels of histamine, immunoglobulin (Ig)E, IgG, IgM, eosinophil cationic protein (ECP), and interleukin (IL)-4, as well as blood pressure, after injecting QI and its components on the forelimb veins of Beagles were observed.
  
  
  RESULTS
  According to comprehensive determination of abnormal behavior scores and changes in serum levels of histamine, IgE, IgG, IgM, ECP, and IL-4, as well as in blood pressure, radix isatidis and hyodeoxycholic acid caused anaphylactoid reactions, and honeysuckle, radix isatidis, hydrolysate, cholic acid and Gardenia jasminoides caused allergic reactions. The anaphylaxis of QI involved anaphylactoid and allergic reactions.
  
  
  CONCLUSIONS
  QI and its components need to be refined further to improve the safety, efficacy, and quality of its use in clinical settings.
authors: Medical Experiment Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Zhiguo
authors: Z
authors: Wang
authors: Danqiao
authors: D
authors: Wang
authors: Yu
authors: Y
authors: Sui
authors: Haifeng
authors: H
authors: Cui
authors: Youhua
authors: Y
authors: Yu
mesh_terms: D000707:Anaphylaxis / Q000209:etiology / Q000276:immunology*; D000818:Animals; D004285:Dogs; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology / Q000276:immunology*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D004365:Drugs, Chinese Herbal; C504928:Qingkailing