title: Tuberculosis: time for a new perspective?
abstract: Transmission of Mycobacterium tuberculosis (Mtb) continues uninterrupted. Pre-exposure vaccination remains a central focus of tuberculosis research but 25 years of follow up is needed to determine whether a novel childhood vaccination regime protects from adult disease, or like BCG assists Mtb dissemination by preventing childhood illness but not infective adult pulmonary tuberculosis. Therefore, different strategies to interrupt the life cycle of Mtb need to be explored. This personal perspective discusses alternative approaches that may be delivered in a shorter time frame.
authors: Clinical and Experimental Sciences, University of Southampton, Mailpoint 811, Southampton General Hospital, Southampton SO16 1YD, UK. p.elkington@soton.ac.uk
authors: Paul T
authors: PT
authors: Elkington
mesh_terms: D001500:BCG Vaccine / Q000276:immunology; D003895:Desmosine / Q000032:analysis*; D006801:Humans; D008168:Lung / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology / Q000635:transmission*; D014611:Vaccination
chemical_list: D001500:BCG Vaccine; D003895:Desmosine