title: Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers.
abstract: This study aims to confirm the feasibility of near-infrared (NIR) fluorescence imaging for sentinel lymph node (SLN) biopsy in vulvar cancer and to compare the tracer indocyanine green (ICG) bound to human serum albumin (HSA) versus ICG alone. Women received 99mTc-nanocolloid and patent blue for SLN detection. Subsequently, women randomly received ICG:HSA or ICG alone. In 24 women, 35 SLNs were intraoperatively detected. All SLNs detected were radioactive and NIR fluorescent and 27 (77%) were blue. No significant difference was found between ICG:HSA and ICG alone. This trial confirms the feasibility of NIR fluorescence imaging for SLN mapping in vulvar cancer.
authors: Department of Surgery, Leiden University Medical Centre, Leiden, the Netherlands.
authors: B E
authors: BE
authors: Schaafsma
authors: F P R
authors: FP
authors: Verbeek
authors: A A W
authors: AA
authors: Peters
authors: J R
authors: JR
authors: van der Vorst
authors: C D
authors: CD
authors: de Kroon
authors: M I E
authors: MI
authors: van Poelgeest
authors: J B M Z
authors: JB
authors: Trimbos
authors: C J H
authors: CJ
authors: van de Velde
authors: J V
authors: JV
authors: Frangioni
authors: A L
authors: AL
authors: Vahrmeijer
authors: K N
authors: KN
authors: Gaarenstroom
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000032:analysis; D004311:Double-Blind Method; D005240:Feasibility Studies; D005260:Female; D005453:Fluorescence; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods*; D007208:Indocyanine Green; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D000418:Albumins; D007208:Indocyanine Green