title: Lipoprotein X in a patient with cholestasis and hypertriglyceridaemia.
abstract: Hypertriglyceridaemia is an established cause of acute pancreatitis and responds to insulin therapy in addition to lipid lowering medication. We report a case of severe hypertriglycaeridemia of 149 mmol/L in a 36-year-old man with type 2 diabetes who presented to the surgical ward with abdominal pain due to pancreatitis and developed acute cholestasis, jaundice and eruptive xanthomata. His triglycerides improved to 3.8 mmol/L with sliding scale insulin within two weeks of in-hospital stay. However, his total cholesterol remained raised at 23.7 mmol/L. The lipoprotein electrophoresis confirmed the presence of lipoprotein X associated with bile obstruction, which contributed to an increase in total cholesterol. The total cholesterol normalized on improvement of his cholestasis.
authors: Nottingham University Hospitals Trust, Hucknall Road, Nottingham NG5 1PB, UK. kstepien@doctors.org.uk
authors: Karolina M
authors: KM
authors: Stepien
authors: Hrushikesh
authors: H
authors: Divyateja
authors: Farhan
authors: F
authors: Ahmed
authors: Peter
authors: P
authors: Prinsloo
authors: Pankaj
authors: P
authors: Gupta
mesh_terms: D000328:Adult; D002779:Cholestasis / Q000097:blood* / Q000150:complications* / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications*; D008073:Lipoprotein-X / Q000097:blood*; D008297:Male
chemical_list: D008073:Lipoprotein-X