title: Serum profile of T helper 1 and T helper 2 cytokines in hepatitis C virus infected patients.
abstract: BACKGROUND
  T-helper (Th) lymphocyte cytokine production may be important in the immune pathogenesis of hepatitis C virus (HCV) infections. Th1 cytokines such as; interleukin-2 (IL-2), and interferon gamma (IFN-gamma) are necessary for host antiviral immune responses, while Th2 cytokines (IL-4, IL-10) can inhibit the development of these effector mechanisms.
  
  
  OBJECTIVE
  The aim of the present study was to assess the serum profile of Th1 and Th2 cytokines in treated and non-treated HCV infected individuals.
  
  
  METHODS
  This study was carried out in 63 HCV infected patients (31 under treatment and 32 untreated) and 32 matched HCV-sero negative healthy subjects. Serum samples were checked with an enzyme-linked immune sorbent assay (ELISA) for IL-2, IL-4, IL-10 and IFN-gamma.
  
  
  RESULTS
  Levels of circulating IL-2, IL-4, IL-10 and IFN-gamma were significantly elevated in HCV patients versus normal controls (2 822.6 ± 1 259.92 vs. 950.8 ± 286.9 pg/mL; 1 987 ± 900.69 vs. 895.91 ± 332.33 pg/mL; 1 688.5 ± 1 405.1 vs. 519.03 ± 177.64 pg/mL and 1 501.9 ± 1 298 vs. 264.66 ± 71.59 pg/mL, respectively; P < 0.001). The serum levels of all cytokines were significantly lower in the patients under treatment than those of the untreated patients (P < 0.001).
  
  
  CONCLUSIONS
  On the basis of our data, the simultaneous increase of Th1 and Th2 related cytokines may indicate that both Thl and Th2 cytokines are involved in the pathogenesis of HCV infections. Moreover, this activated T-cell response in HCV infected patients may be regulated by treatment.
authors: Tuberculosis and Pediatric Infectious Research Center (TPIRC), Arak University of Medical Sciences, Arak, IR Iran.
authors: Masoomeh
authors: M
authors: Sofian
authors: Arezoo
authors: A
authors: Aghakhani
authors: Ali Asghar
authors: AA
authors: Farazi
authors: Mohammad
authors: M
authors: Banifazl
authors: Ali
authors: A
authors: Eslamifar
authors: Niloofar
authors: N
authors: Rashidi
authors: Akbar
authors: A
authors: Khadem Sadegh
authors: Amitis
authors: A
authors: Ramezani
keywords: Cytokines; Hepatitis C; Th1 Cells; Th2 Cells