title: Combined repeated-dose toxicity study of silver nanoparticles with the reproduction/developmental toxicity screening test.
abstract: Combined repeated-dose toxicity study of citrate-capped silver nanoparticles (7.9 ± 0.95 nm) with reproduction/developmental toxicity was investigated in rats orally treated with 62.5, 125 and 250 mg/kg, once a day for 42 days for males and up to 52 days for females. The test was performed based on the Organization for Economic Cooperation and Development test guideline 422 and Good Laboratory Practice principles. No death was observed in any of the groups. Alopecia, salivation and yellow discolouration of the lung were observed in a few rats but the symptoms were not dose-dependent. Haematology, serum biochemical investigation and histopathological analysis revealed no statistically significant differences between control group and the treated groups. Toxicity endpoints of reproduction/developmental screening test including mating, fertility, implantation, delivery and foetus were measured. There was no evidence of toxicity.
authors: Korea Testing and Research Institute, Health Care Research and Creation , Gimpo , Korea.
authors: Jeong-Sup
authors: JS
authors: Hong
authors: Suhyon
authors: S
authors: Kim
authors: Sang Hee
authors: SH
authors: Lee
authors: Eunhye
authors: E
authors: Jo
authors: Byungcheun
authors: B
authors: Lee
authors: Junheon
authors: J
authors: Yoon
authors: Ig-Chun
authors: IC
authors: Eom
authors: Hyun-Mi
authors: HM
authors: Kim
authors: Pilje
authors: P
authors: Kim
authors: Kyunghee
authors: K
authors: Choi
authors: Moo Yeol
authors: MY
authors: Lee
authors: Yeong-Rok
authors: YR
authors: Seo
authors: Younghun
authors: Y
authors: Kim
authors: Yeonjin
authors: Y
authors: Lee
authors: Jonghye
authors: J
authors: Choi
authors: Kwangsik
authors: K
authors: Park
mesh_terms: D000818:Animals; D001769:Blood / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D053768:Metal Nanoparticles / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects*; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects*; D012834:Silver / Q000493:pharmacokinetics / Q000633:toxicity*; D014018:Tissue Distribution; D018675:Toxicity Tests
chemical_list: D012834:Silver