title: Determinants of alveolar ridge preservation differ by anatomic location.
abstract: OBJECTIVE
  To investigate and compare outcomes following alveolar ridge preservation (ARP) in posterior maxilla and mandible.
  
  
  METHODS
  Twenty-four patients (54 ± 3 years) with single posterior tooth extraction were included. ARP was performed with freeze-dried bone allograft and collagen membrane. Clinical parameters were recorded at extraction and re-entry. Harvested bone cores were analysed by microcomputed tomography (micro-CT), histomorphometry and immunohistochemistry.
  
  
  RESULTS
  In both jaws, ARP prevented ridge height loss, but ridge width was significantly reduced by approximately 2.5 mm. Healing time, initial clinical attachment loss and amount of keratinized tissue at extraction site were identified as determinants of ridge height outcome. Buccal plate thickness and tooth root length were identified as determinants of ridge width outcome. In addition, initial ridge width was positively correlated with ridge width loss. Micro-CT revealed greater mineralization per unit volume in new bone compared with existing bone in mandible (p < 0.001). Distributions of residual graft, new cellular bone and immature tissue were similar in both jaws.
  
  
  CONCLUSIONS
  Within the limitations of this study, the results indicate that in different anatomic locations different factors may determine ARP outcomes. Further studies are needed to better understand determinants of ARP outcomes.
authors: Division of Periodontology, College of Dentistry, The Ohio State University, OH 43210, USA. leblebicioglu.1@osu.edu
authors: Binnaz
authors: B
authors: Leblebicioglu
authors: Mabel
authors: M
authors: Salas
authors: Yirae
authors: Y
authors: Ort
authors: Ashley
authors: A
authors: Johnson
authors: Vedat O
authors: VO
authors: Yildiz
authors: Do-Gyoon
authors: DG
authors: Kim
authors: Sudha
authors: S
authors: Agarwal
authors: Dimitris N
authors: DN
authors: Tatakis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016301:Alveolar Bone Loss / Q000209:etiology / Q000517:prevention & control*; D000539:Alveolar Process / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D001861:Bone Regeneration; D016025:Bone Transplantation; D016009:Chi-Square Distribution; D003094:Collagen / Q000627:therapeutic use; D003758:Dental Implantation, Endosseous / Q000379:methods*; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D014081:Tooth Extraction / Q000009:adverse effects / Q000379:methods; D020390:Tooth Socket / Q000601:surgery*; D016896:Treatment Outcome; D055114:X-Ray Microtomography; D055815:Young Adult
chemical_list: D008567:Membranes, Artificial; D003094:Collagen