title: Large measles outbreak in Geneva, Switzerland, January to August 2011: descriptive epidemiology and demonstration of quarantine effectiveness.
abstract: Between January and August 2011, the canton of Geneva, Switzerland, experienced a large measles outbreak with 219 cases (47 cases per 100,000 inhabitants) in the context of an extensive epidemic in a neighbouring region of France. Most cases were young adults (median age: 18 years), often unaware of their vaccination status. The vast majority of cases were either not (81%) or incompletely vaccinated (8%). Thirty clusters with a total of 119 cases and a median cluster size of three (range: 2–15 cases) were identified. Overall, 44 cases were imported or linked to imported cases. Of 73 contacts of cases who were quarantined, 50 developed measles and caused six secondary cases. This compares to 81 secondary cases among 173 non-quarantined cases (relative risk: 0.26; 95% confidence interval: 0.06–0.65), demonstrating the effectiveness of well targeted quarantine measures in reducing transmission.
authors: Epidemiology and infectious diseases section, Cantonal Health Service, General Directorate for Health, Geneva, Switzerland.
authors: E
authors: E
authors: Delaporte
authors: C A
authors: CA
authors: Wyler Lazarevic
authors: A
authors: A
authors: Iten
authors: P
authors: P
authors: Sudre
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D004196:Disease Outbreaks / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008457:Measles / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D008459:Measles virus / Q000235:genetics / Q000302:isolation & purification*; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D056990:Post-Exposure Prophylaxis; D015397:Program Evaluation; D011790:Quarantine; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013557:Switzerland / Q000453:epidemiology; D014611:Vaccination / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D022542:Measles-Mumps-Rubella Vaccine