title: Partial recovery of peristalsis after myotomy for achalasia: more the rule than the exception.
abstract: OBJECTIVE
  Although successful treatment of achalasia depends on alleviating the obstruction at the esophagogastric junction, the postintervention contractile and pressurization pattern may also play a role in outcome.
  
  
  OBJECTIVE
  To determine whether myotomy that alleviates the esophagogastric junction outflow obstruction in achalasia might improve peristalsis.
  
  
  METHODS
  Retrospective study from August 1, 2004, through January 30, 2012.
  
  
  METHODS
  Two tertiary care hospitals in Chicago and Lyon.
  
  
  METHODS
  We included 30 patients (18 male; mean age [range], 43 [17-78] years), of whom 8 had type 1 (26.6%), 17 had type 2 (56.7%), and 5 (16.7%) had type 3 achalasia according to the Chicago classification.
  
  
  METHODS
  Esophageal high-resolution manometry before and after laparoscopic or endoscopic myotomy.
  
  
  METHODS
  The integrity of peristalsis, characterized as intact, weak contractions; frequent failed peristalsis; or premature contractions.
  
  
  RESULTS
  Although peristaltic fragments were evident only in patients with type 3 achalasia before treatment, intact, weak, or frequent failed peristalsis was encountered in 5 patients with type 1 (63%), 8 with type 2 (47%), and 4 with type 3 (80%) achalasia after myotomy. One patient with type 3 achalasia had distal esophageal spasm after treatment. In patients with a postmyotomy integrated relaxation pressure of less than 15 mm Hg, only 10 (40%) had persistent absent peristalsis. Panesophageal pressurization disappeared after myotomy in 16 of 19 patients. In the 5 patients with postmyotomy integrated relaxation pressure of more than 15 mm Hg, 4 had weak peristalsis and 1 had absent peristalsis.
  
  
  CONCLUSIONS
  Reduction or normalization of the esophagogastric junction relaxation pressure achieved by myotomy in achalasia is associated with partial recovery of peristalsis in some patients, suggesting that the disease process progresses from the esophagogastric junction to the esophageal body. Whether the return of peristalsis is predictive of an improved therapeutic outcome requires further study.
authors: Department of Digestive Physiology, Edouard Herriot Hospital, Pavillon H, 5 place d’Arsonval, 69437 Lyon, CEDEX 03, France. roman.sabine@gmail.com
authors: Sabine
authors: S
authors: Roman
authors: Peter J
authors: PJ
authors: Kahrilas
authors: François
authors: F
authors: Mion
authors: Thomas B
authors: TB
authors: Nealis
authors: Nathaniel J
authors: NJ
authors: Soper
authors: Gilles
authors: G
authors: Poncet
authors: Frédéric
authors: F
authors: Nicodème
authors: Eric
authors: E
authors: Hungness
authors: John E
authors: JE
authors: Pandolfino
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004931:Esophageal Achalasia / Q000503:physiopathology* / Q000601:surgery; D004947:Esophagus / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010528:Peristalsis / Q000502:physiology*; D011312:Pressure; D020127:Recovery of Function; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult