title: Broadening the catalyst and reaction scope of regio- and chemoselective C-H oxygenation: a convenient and scalable approach to 2-acylphenols by intriguing Rh(II) and Ru(II) catalysis.
abstract: A unique Rh(II) and Ru(II) catalyzed C-H oxygenation of aryl ketones and other arenes has been developed for the facile synthesis of diverse functionalized phenols. The reaction demonstrates excellent reactivity, regio- and chemoselectivity, good functional group compatibility and high yields. The practicality of this method has been proved by gram-scale synthesis of a few different 2-acylphenols. Its utility has been well exemplified in further applications in heterocycle synthesis and direct modifications of drug Fenofibrate.
authors: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084, China.
authors: Gang
authors: G
authors: Shan
authors: Xuesong
authors: X
authors: Han
authors: Yun
authors: Y
authors: Lin
authors: Shanyou
authors: S
authors: Yu
authors: Yu
authors: Y
authors: Rao
mesh_terms: D000215:Acylation; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D010636:Phenols / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D010636:Phenols; D012428:Ruthenium; D012238:Rhodium; D010100:Oxygen