title: Early decrease of serum biomarkers of type II collagen degradation (Coll2-1) and joint inflammation (Coll2-1 NO₂ ) by hyaluronic acid intra-articular injections in patients with knee osteoarthritis: a research study part of the Biovisco study.
abstract: To measure the evolution of the serum levels of specific Osteoarthritis (OA) biomarker, Coll2-1 and Coll2-1 NO₂ in knee osteoarthritic patients after viscosupplementation (VS). Fifty-one patients with unilateral symptomatic knee were recruited for this prospective open label study. They received three intra-articular injections of 2 ml of hyaluronic acid (Hylan GF-20) and were followed for 3 months. Walking pain was evaluated and serum samples were taken at each visit. Coll2-1 and Coll2-1 NO₂ were measured in the serum using specific immunoassays. Variations over time of each parameter and predictive factor of response were studied. Forty-five patients were analyzed. The serum concentrations of Coll2-1 and Coll2-1 NO₂ were significantly higher in KL III/IV patients compared to KL I/II patients at baseline and decreased systematically over time after VS. Its effect was ever more pronounced in patients with KL III/IV. The serum concentration of Coll2-1 was significantly lower at baseline in responders than in non-responders. This study suggests a rapid slowdown of type II collagen degradation and joint inflammation after VS with Hylan G-20 and gives additional information for the validation of accurate biomarkers for OA. The serum level of Coll2-1 appeared to be a predictive factor for response to treatment.
authors: Bone and Cartilage Research Unit, University of Liège, Institute of Pathology, Level 5, Chu Sart-Tilman, 4000 Liège, Belgium. yhenrotin@ulg.ac.be
authors: Y
authors: Y
authors: Henrotin
authors: X
authors: X
authors: Chevalier
authors: M
authors: M
authors: Deberg
authors: J C
authors: JC
authors: Balblanc
authors: P
authors: P
authors: Richette
authors: D
authors: D
authors: Mulleman
authors: B
authors: B
authors: Maillet
authors: F
authors: F
authors: Rannou
authors: C
authors: C
authors: Piroth
authors: P
authors: P
authors: Mathieu
authors: T
authors: T
authors: Conrozier
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D024043:Collagen Type II / Q000097:blood*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000188:drug therapy*; D010446:Peptide Fragments / Q000097:blood*; D011446:Prospective Studies; D055675:Viscosupplements / Q000008:administration & dosage*
chemical_list: D015415:Biomarkers; D024043:Collagen Type II; D010446:Peptide Fragments; D055675:Viscosupplements; C510280:collagen type II (108-116); C510281:collagen type II (108-116), (NO2)Tyr(111)-; D006820:Hyaluronic Acid