title: Effects of pregabalin on behavioral alterations induced by ketamine in rats.
abstract: OBJECTIVE
  The aim of this study is to investigate the effects of pregabalin on the behavior of rats under the influence of ketamine, an NMDA receptor antagonist that mimics the symptoms of schizophrenia.
  
  
  METHODS
  Rats were injected with saline or 25 mg/kg ketamine intraperitoneally. After that, behavior modifications were investigated by the evaluation of stereotypy and hyperlocomotion, after treating rats with pregabalin (at doses of 30 mg/kg or 100 mg/kg) or placebo (saline solution).
  
  
  RESULTS
  The administration of pregabalin reduced ketamine-induced hyperlocomotion. However, neither doses of pregabalin had a significant effect on ketamineinduced stereotypy.
  
  
  CONCLUSIONS
  This is the first study to investigate the effects of pregabalin using an animal model of psychosis. Furthermore, our results indicate that behavioral changes induced by ketamine in rats can be reversed with the use of pregabalin, suggesting its potential to treat psychotic symptoms.
authors: Department of Neuroscience and Behavior, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil. emerson_arcoverde@yahoo.com.br
authors: Emerson Arcoverde
authors: EA
authors: Nunes
authors: Leila
authors: L
authors: Canever
authors: Larissa de
authors: Ld
authors: Oliveira
authors: Renata D'altoe de
authors: RD
authors: Luca
authors: João
authors: J
authors: Quevedo
authors: Alexandra
authors: A
authors: Zugno
authors: Antonio
authors: A
authors: Peregrino
authors: José Alexandre S
authors: JA
authors: Crippa
authors: Serdar M
authors: SM
authors: Dursun
authors: Glen B
authors: GB
authors: Baker
authors: Jaime Eduardo C
authors: JE
authors: Hallak
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001522:Behavior, Animal / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D000069583:Pregabalin; D011605:Psychoses, Substance-Induced / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D012559:Schizophrenia / Q000139:chemically induced / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D014150:Antipsychotic Agents; D018691:Excitatory Amino Acid Antagonists; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D007649:Ketamine