title: [Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi].
abstract: OBJECTIVE
  To assess the association between SIRT1 gene polymorphisms and the longevity phenomena in Yongfu region of Guangxi. In this case-control study, 500 individuals from Yongfu region of Guangxi were recruited. The subjects were divided into a longevity group (n=223, average age=93.17 U+00B1 3.08 yr) and a healthy control group (n=277, average age=46.92 U+00B1 17.12 yr). Polymerase chain reaction-high resolution melting curve (PCR-HRM) and DNA sequencing were used to determine the allelic and genotypic frequencies of rs3758391, rs3740051, rs2273773, rs4746720 and rs10997870 polymorphisms of SIRT1 gene in the two groups. The association between above polymorphisms and longevity was assessed.
  
  
  RESULTS
  In the longevity group, CT genotype of the rs4746720 locus was significantly more common than CC and TT genotypes (P=0.000, OR=2.098, 95%CI:1.412-4.117). However, no significant difference was found in the allelic and genotypic frequencies of rs3758391, rs3740051 and rs2273773 between the two groups.
  
  
  CONCLUSIONS
  There is an association between rs4746720 of SIRT1 gene and longevity in Yongfu region of Guangxi.
authors: The 5th Medical College of Peking University, Beijing, People's Republic of China.
authors: Jin
authors: J
authors: Huang
authors: Liang
authors: L
authors: Sun
authors: Ming
authors: M
authors: Liu
authors: Lin
authors: L
authors: Zhou
authors: Ze-ping
authors: ZP
authors: Lv
authors: Cai-you
authors: CY
authors: Hu
authors: Ze-zhi
authors: ZZ
authors: Huang
authors: Chen-guang
authors: CG
authors: Zheng
authors: Lin
authors: L
authors: Zhou
authors: Ze
authors: Z
authors: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D023061:Gene Order; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D056564:Sirtuin 1 / Q000235:genetics*; D055815:Young Adult
chemical_list: D056564:Sirtuin 1