title: Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis.
abstract: An efficient one-pot nitro-Mannich/hydroamination cascade reaction for the synthesis of substituted pyrrolidines bearing three stereocentres is reported. Proceeding under the control of a combination of base and gold(I) catalysts, the cascade reaction affords the pyrrolidine products in high yields with good to excellent diastereoselectivities.
authors: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. darren.dixon@chem.ox.ac.uk.
authors: Andrej
authors: A
authors: Ďuriš
authors: David M
authors: DM
authors: Barber
authors: Hitesh J
authors: HJ
authors: Sanganee
authors: Darren J
authors: DJ
authors: Dixon
mesh_terms: D000586:Amination; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008352:Mannich Bases / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D008352:Mannich Bases; D009574:Nitro Compounds; D011759:Pyrrolidines; D006046:Gold