title: Biological correlates of major depression and generalized anxiety disorder in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  We aimed to compare the levels of serum androgens in women with polycystic ovary syndrome (PCOS) who had a diagnosis of only major depressive disorder (MDD), only generalized anxiety disorder (GAD) or who had no psychiatric disorder, as determined by a structured clinical interview. Another objective of the study was to examine whether an association exists between these psychiatric diagnoses and insulin resistance or body mass index via a comparison among the study groups in terms of these parameters.
  
  
  METHODS
  This study was performed between March 2011 and February 2012. A total of 73 patients were included in the study. The study sample consisted of three groups: PCOS patients with only major depressive disorder (n=23), PCOS patients with only generalized anxiety disorder (n=20), and PCOS patients without any diagnosed psychiatric disorders (not diagnosed - ND group, n=30).
  
  
  RESULTS
  Significant difference was found among the three groups with regard to the serum levels of 17-OHP and DHEAS. When multiple comparisons were performed among the groups, 17-OHP levels were significantly higher in the MDD group than in the ND group. DHEAS levels were significantly higher in the MDD group and the GAD group than in the ND group.
  
  
  CONCLUSIONS
  The present study suggests that MDD and GAD appear to be associated with higher DHEAS levels.
authors: Department of Psychiatry, Selçuklu Medical School, Selçuk University, Konya 42075, Turkey. bilgeannagur@yahoo.com
authors: Bilge Burçak
authors: BB
authors: Annagür
authors: Aybike
authors: A
authors: Tazegül
authors: Faruk
authors: F
authors: Uguz
authors: Özlem Seçilmiş
authors: ÖS
authors: Kerimoglu
authors: Emine
authors: E
authors: Tekinarslan
authors: Çetin
authors: Ç
authors: Celik
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000097:blood / Q000453:epidemiology*; D015992:Body Mass Index; D015897:Comorbidity; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology*; D011374:Progesterone / Q000097:blood*; D055815:Young Adult
chemical_list: D011374:Progesterone; D019314:Dehydroepiandrosterone Sulfate