title: Proposal for a predictive model of erectile function after permanent (125)I prostate brachytherapy for localized prostate cancer.
abstract: To determine the risk factors for EDin men treated by prostate brachytherapy (PB) for localized prostate cancer and to propose a model to predict post-implant erectile function. Out of a series of 270 sexually active men treated by PB, 241 (89%) (mean age=66 years (range, 43-80)) accepted to participate in a mail-based study on erectile function. The risk factors for erectile dysfunction were determined by regression analysis and a predictive model was proposed. The performance of the model was determined in this population and subsequently verified in a population of 50 men treated by PB in another treatment center. The risk factors for ED after PB were age, the pre-implant IIEF score and prostate volume. In the studied population, the final model to predict a post-treatment IIEF-5 score, using these factors, had a sensitivity of 69% and a specificity of 68% associated to an area under the ROC curve (AUC) of 0.75. The same performance was obtained in another treatment center. Age, pre-implant IIEF-5 score and prostate volume may be used to predict post-implant erectile function in patients treated by PB.
authors: Department of Urology and Andrology, University Hospital, CHU Rangueil, Toulouse, France. eric.huyghe@yahoo.fr
authors: E
authors: E
authors: Huyghe
authors: B
authors: B
authors: Delaunay
authors: P
authors: P
authors: Njomnang Soh
authors: M
authors: M
authors: Delannes
authors: M
authors: M
authors: Walschaerts
authors: D
authors: D
authors: Delavierre
authors: M
authors: M
authors: Soulie
authors: J M
authors: JM
authors: Bachaud
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects*; D007172:Erectile Dysfunction / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010410:Penile Erection; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires