title: Prevalence of multiple forms of autoimmunity in Egyptian patients with Turner syndrome: relation to karyotype.
abstract: Our study aimed to investigate: the prevalence of autoantibodies related to organ-specific disease; the prevalence of some autoimmune diseases (AID) in Egyptian Turner syndrome (TS) patients; and the association of autoimmunity with patients' karyotypes. Eighty TS patients were subjected to history, auxological assessment and measurement of antithyroid peroxidase antibody (ATPOAb), antithyroglobulin antibody (ATGAb), anti-tissue transglutaminase IgA antibodies (ATTIgAAb), anti-glutamic acid decarboxylase-65 antibodies (GAD-65-Ab) and anti-adrenal cortex antibodies (AACAb). Of the 80 TS patients, 54 (67.5%) were seropositive for one or more autoantibodies. Thirty-five percent were positive for ATPOAb, 15% for ATGAb, 12.5% for ATTIgAAb, 3.75% for Anti-GAD-65Ab and 1.25% for AACAb. There was a non-significant association between the 45,X karyotype and overall prevalence of autoantibodies (p=0.20), while IsoXq was associated with increased prevalence of ATPOAb (p<0.01), ATGAb (p=0.01) and anti-GAD-65Ab (p=0.02). Thus, female TS patients face a high prevalence of autoimmunity and associated AID.
authors: Department of Pediatrics, Ain Shams University, 36 Hisham Labib street, off Makram Ebeid street, Nasr City, Cairo, 11371, Egypt. rashatarif_2000@hotmail.com
authors: Rasha T
authors: RT
authors: Hamza
authors: Nader A
authors: NA
authors: Raof
authors: Khaled O
authors: KO
authors: Abdallah
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D007037:Hypothyroidism / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D007621:Karyotyping; D008297:Male; D015995:Prevalence; D016036:Seroepidemiologic Studies; D014424:Turner Syndrome / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
chemical_list: D001323:Autoantibodies