title: Does cow's milk protein elimination diet have a role on induction and maintenance of remission in children with ulcerative colitis?
abstract: OBJECTIVE
  Aims of this study were to evaluate the efficacy of a cow's milk protein (CMP) elimination diet on induction and maintenance of remission and to define association with atopy in children with ulcerative colitis (UC).
  
  
  METHODS
  Twenty-nine consecutive patients (mean age: 11.2 years; range: 4.6-17 years; F/M: 15/14) with newly diagnosed UC were randomized either to receive a CMP elimination diet (n = 14) or to continue a free diet (n = 15) associated with concomitant steroid induction and mesalazine maintenance treatment. Children were prospectively evaluated at four time points: within 1 month, 6 months and 1 year after diagnosis or at the time of relapse.
  
  
  RESULTS
  Twenty-five of the 29 enrolled patients responded to the UC induction therapy with a complete remission (86.2%), 13 belonging to CMP elimination diet group and 12 to free diet group (p = 0.59). Overall, our data showed that 7 of 13 (53.8%) patients treated with CMP elimination diet and 8 of 15 (53.3%) patients on free diet and UC therapy relapsed within 1 year of follow-up (p = 1).
  
  
  CONCLUSIONS
  In conclusion, data of this paediatric, randomized trial suggest that CMP elimination has no role in the management of UC in non-sensitized children.
authors: Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples, Italy.
authors: Caterina
authors: C
authors: Strisciuglio
authors: Eleonora
authors: E
authors: Giannetti
authors: Massimo
authors: M
authors: Martinelli
authors: Elisa
authors: E
authors: Sciorio
authors: Annamaria
authors: A
authors: Staiano
authors: Erasmo
authors: E
authors: Miele
mesh_terms: D000293:Adolescent; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008892:Milk; D016269:Milk Hypersensitivity / Q000453:epidemiology*; D011446:Prospective Studies; D012074:Remission Induction