title: Expression of fibrocyte markers by keloid fibroblasts: an insight into fibrosis during burn wound healing - a preliminary study.
abstract: In extensive burns it becomes difficult for fibroblasts to migrate from the periphery of the healthy tissue and colonize the injured area. Even under such circumstances healing takes place, and this is attributed to the differentiation of circulating fibrocytes which enter the wound site. This normal cell type is identified in keloid fibroblasts: it expresses fibrocyte markers and secretes extra cellular matrix proteins. In-vitro collagen contraction assay reveals that fibrocytes contract collagen gels with an efficacy similar to normal fibroblasts. The contribution of fibrocytes to the formation of keloid fibroblasts in post-burn healing is discussed.
authors: Childs Trust Medical Research Foundation and Kanchi Kamakoti Childs Trust Hospital 12-A, Nageswara Road, Chennai-600 003, India.
authors: K
authors: K
authors: Mathangi Ramakrishnan
authors: M
authors: M
authors: Meenakshi Janakiraman
authors: M
authors: M
authors: Babu
keywords: collagen gel; fibrocytes; keloid fibroblasts