title: [Roles of RORγt+ innate lymphoid cells in mucosal tissues of mouse and human].
abstract: Innate Lymphoid cells (ILCs) are recently defined lymphocytes composed of several subsets such as Natural Killer (NK), Natural Helper (NH) and RORγt(+) cells, which have no antigen receptors but exhibit rapid cytokine production after stimulation. Murine RORγt(+) ILCs can be classified either as CCR6(+)c-kit(high)IL-7Rα(high) or CCR6NK(-)p46(+) cells. The former ones play roles on the formation of secondary lymphoid tissues and the later ones contribute to the maintenance of intestinal epithelial integrity by producing IL-22. Human fetal intestine, tonsil and lympho nodes harbor both NKp44 positive and negative RORγt(+) ILC subsets. Since human Crohn's disease patients have increased number of RORγt(+) ILCs in the inflamed intestine, roles of RORγt(+) ILCs on the pathogenesis of Crohn's disease became of great interest.
authors: Department of Immunology, Graduate School and faculty of Medicine, The University of Tokyo.
authors: Shinichiro
authors: S
authors: Sawa
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003424:Crohn Disease / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007378:Interleukins / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D009092:Mucous Membrane / Q000166:cytology* / Q000276:immunology*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000276:immunology*; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D000097043:Interleukin-22