title: Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm.
abstract: Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the adventitial VV wall in AAA to clarify the histopathological mechanisms underlying AAA. We found marked intimal hyperplasia of the adventitial VV in the AAA sac; further, immunohistological studies revealed proliferation of smooth muscle cells, which caused luminal stenosis of the VV. We also found decreased HemeB signals in the aortic wall of the sac as compared with those in the aortic wall of the neck region in AAA. The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease.
authors: Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Hiroki
authors: H
authors: Tanaka
authors: Nobuhiro
authors: N
authors: Zaima
authors: Takeshi
authors: T
authors: Sasaki
authors: Takahiro
authors: T
authors: Hayasaka
authors: Naoko
authors: N
authors: Goto-Inoue
authors: Kenji
authors: K
authors: Onoue
authors: Koji
authors: K
authors: Ikegami
authors: Yoshifumi
authors: Y
authors: Morita
authors: Naoto
authors: N
authors: Yamamoto
authors: Yuuki
authors: Y
authors: Mano
authors: Masaki
authors: M
authors: Sano
authors: Takaaki
authors: T
authors: Saito
authors: Kohji
authors: K
authors: Sato
authors: Hiroyuki
authors: H
authors: Konno
authors: Mitsutoshi
authors: M
authors: Setou
authors: Naoki
authors: N
authors: Unno
mesh_terms: D063194:Adventitia / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000150:complications* / Q000473:pathology*; D001161:Arteriosclerosis / Q000150:complications* / Q000473:pathology*; D005260:Female; D006418:Heme / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008055:Lipids / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D014651:Vasa Vasorum / Q000473:pathology*
chemical_list: D008055:Lipids; D006418:Heme