title: Immunohistochemical expression of CD44s in human neuroblastic tumors: Moroccan experience and highlights on current data.
abstract: BACKGROUND
  Peripheral neuroblastic tumors (pNTs), including neuroblastoma (NB), ganglioneuroblastoma (GNB) and ganglioneuroma (GN), are extremely heterogeneous pediatric tumors responsible for 15 % of childhood cancer death. The aim of the study was to evaluate the expression of CD44s ('s': standard form) cell adhesion molecule by comparison with other specific prognostic markers.
  
  
  METHODS
  An immunohistochemical profile of 32 formalin-fixed paraffin-embedded pNTs tissues, diagnosed between January 2007 and December 2010, was carried out.
  
  
  RESULTS
  Our results have demonstrated the association of CD44s negative pNTs cells to lack of differentiation and tumour progression. A significant association between absence of CD44s expression and metastasis in human pNTs has been reported. We also found that expression of CD44s defines subgroups of patients without MYCN amplification as evidenced by its association with low INSS stages, absence of metastasis and favorable Shimada histology.
  
  
  CONCLUSIONS
  These findings support the thesis of the role of CD44s glycoprotein in the invasive growth potential of neoplastic cells and suggest that its expression could be taken into consideration in the therapeutic approaches targeting metastases.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1034403150888863
authors: Laboratory of Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy of Casablanca, Hassan II Aïn Chock University, 19 rue Tarik Ibn Ziad, Casablanca, Morocco.
authors: Imane
authors: I
authors: Tabyaoui
authors: Nadia
authors: N
authors: Tahiri-Jouti
authors: Zineb
authors: Z
authors: Serhier
authors: Mohamed
authors: M
authors: Bennani-Othmani
authors: Hicham
authors: H
authors: Sibai
authors: Mohamed
authors: M
authors: Itri
authors: Said
authors: S
authors: Benchekroun
authors: Soumaya
authors: S
authors: Zamiati
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D002454:Cell Differentiation; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D005404:Fixatives; D005557:Formaldehyde; D018305:Ganglioneuroblastoma / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005729:Ganglioneuroma / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D005784:Gene Amplification; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007231:Infant, Newborn; D016013:Likelihood Functions; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D009018:Morocco; D015999:Multivariate Analysis; D000071447:N-Myc Proto-Oncogene Protein; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics; D015513:Oncogene Proteins / Q000235:genetics; D016612:Paraffin Embedding; D011379:Prognosis; D012189:Retrospective Studies; D016707:Tissue Fixation / Q000379:methods; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C497483:CD44 protein, human; D005404:Fixatives; D018960:Hyaluronan Receptors; C459801:MYCN protein, human; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D005557:Formaldehyde