title: Toward quantifying the thymic dysfunctional state in mouse models of inflammatory bowel disease.
abstract: Inflammatory bowel disease is characterized by a number of immunological alterations, not the least in the T-cell compartment. Numerous animal models of colitis have revealed aberrant thymocyte dynamics associated with skewed thymocyte development. The recent advancements in quantitative methods have proposed critical kinetic alterations in the thymocyte development during the progression of colitis. This review focuses on the aberrant thymocyte dynamics in Gαi2-deficient mice as this mouse model provides most quantitative data of the thymocyte development associated with colitis. Herein, we discuss several dynamic changes during the progression of colitis and propose a hypothesis for the underlying causes for the skewed proportions of the thymocyte populations seen in the Gαi2-deficient mice and in other mouse models of colitis.
authors: School of Life Sciences, Systems Biology Research Centre, University of Skövde, Skövde, Sweden. andreas.jansson@his.se
authors: Andreas
authors: A
authors: Jansson
authors: Anna-Karin
authors: AK
authors: Pernestig
authors: Patric
authors: P
authors: Nilsson
authors: Mats
authors: M
authors: Jirstrand
authors: Elisabeth
authors: E
authors: Hultgren Hörnquist
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D051960:GTP-Binding Protein alpha Subunit, Gi2 / Q000172:deficiency* / Q000235:genetics; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000473:pathology*; D051379:Mice; D060168:Thymocytes / Q000473:pathology*
chemical_list: D051960:GTP-Binding Protein alpha Subunit, Gi2