title: A new 5α,8α-Epidioxysterol from the soft coral Sinularia gaweli.
abstract: A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1-3 towards various tumor cells is reported.
authors: Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. wzh@mail.nsysu.edu.tw
authors: Wei-Hsuan
authors: WH
authors: Yen
authors: Wu-Fu
authors: WF
authors: Chen
authors: Ching-Hsiao
authors: CH
authors: Cheng
authors: Chang-Feng
authors: CF
authors: Dai
authors: Mei-Chin
authors: MC
authors: Lu
authors: Jui-Hsin
authors: JH
authors: Su
authors: Yin-Di
authors: YD
authors: Su
authors: Yu-Hsin
authors: YH
authors: Chen
authors: Yu-Chia
authors: YC
authors: Chang
authors: Yung-Husan
authors: YH
authors: Chen
authors: Jyh-Horng
authors: JH
authors: Sheu
authors: Chan-Hsing
authors: CH
authors: Lin
authors: Zhi-Hong
authors: ZH
authors: Wen
authors: Ping-Jyun
authors: PJ
authors: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002788:Cholesterol Esters / Q000737:chemistry* / Q000633:toxicity; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000970:Antineoplastic Agents; D002788:Cholesterol Esters; C421424:epidioxysterol