title: The Deinococcus radiodurans DR1245 protein, a DdrB partner homologous to YbjN proteins and reminiscent of type III secretion system chaperones.
abstract: The bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in growth, exhibiting a generation time approximately threefold that of the wild type strain while radioresistance is not affected. We determined the three-dimensional structure of DR1245, revealing a relationship with type III secretion system chaperones and YbjN family proteins. Thus, DR1245 may display some chaperone activity towards DdrB and possibly other substrates.
authors: Department of Biochemistry, University of Wisconsin College of Agriculture and Life Sciences, Madison, Wisconsin, United States of America.
authors: Cédric
authors: C
authors: Norais
authors: Pascale
authors: P
authors: Servant
authors: Claire
authors: C
authors: Bouthier-de-la-Tour
authors: Pierre-Damien
authors: PD
authors: Coureux
authors: Solenne
authors: S
authors: Ithurbide
authors: Françoise
authors: F
authors: Vannier
authors: Philippe P
authors: PP
authors: Guerin
authors: Charles L
authors: CL
authors: Dulberger
authors: Kenneth A
authors: KA
authors: Satyshur
authors: James L
authors: JL
authors: Keck
authors: Jean
authors: J
authors: Armengaud
authors: Michael M
authors: MM
authors: Cox
authors: Suzanne
authors: S
authors: Sommer
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D058947:Bacterial Secretion Systems; D001483:Base Sequence; D034301:Deinococcus / Q000235:genetics / Q000254:growth & development / Q000378:metabolism* / Q000528:radiation effects; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D009154:Mutation; D011485:Protein Binding; D011487:Protein Conformation; D011836:Radiation Tolerance / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D018832:Molecular Chaperones