title: Translational control of cell growth and malignancy by the CPEBs.
abstract: The cytoplasmic polyadenylation element binding proteins (CPEBs) associate with specific sequences in mRNA 3' untranslated regions to promote translation. They do so by inducing cytoplasmic polyadenylation, which requires specialized poly(A) polymerases. Aberrant expression of these proteins correlates with certain types of cancer, indicating that cytoplasmic RNA 3' end processing is important in the control of growth. Several CPEB-regulated mRNAs govern cell cycle progression, regulate senescence, establish cell polarity, and promote tumorigenesis and metastasis. In this Opinion article, we discuss the emerging evidence that indicates a key role for the CPEBs in cancer biology.
authors: The Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
authors: Andrea
authors: A
authors: D'Ambrogio
authors: Kentaro
authors: K
authors: Nagaoka
authors: Joel D
authors: JD
authors: Richter
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D049109:Cell Proliferation; D016922:Cellular Senescence / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology; D011062:Polynucleotide Adenylyltransferase; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000502:physiology*; D016601:RNA-Binding Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D039221:mRNA Cleavage and Polyadenylation Factors / Q000378:metabolism / Q000502:physiology*
chemical_list: C490386:CPEB1 protein, human; C554938:CPEB2 protein, human; C513866:CPEB3 protein, human; C554939:CPEB4 protein, human; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D039221:mRNA Cleavage and Polyadenylation Factors; D011062:Polynucleotide Adenylyltransferase; C550174:TENT2 protein, human