title: Reirradiation of recurrent salivary gland malignancies with fractionated stereotactic body radiation therapy.
abstract: PURPOSE: The purpose of this study was to review a single-institution experience with the reirradiation of recurrent salivary gland tumors using fractionated stereotactic radiosurgery (SBRT).  METHODS: Between 2003 and 2011, 18 patients diagnosed with recurrent, previously irradiated, salivary gland carcinomas were treated with SBRT reirradiation. Median age was 68 for all patients with most tumors being of major salivary gland origin. Most patients did not undergo surgical resection, and among those that did, all had positive margins. Only seven patients received chemotherapy, and the median SBRT dose was 30 Gy given in five fractions with a median cumulative dose of 91.1 Gy.  RESULTS: The median overall survival (OS), progression-free survival (PFS), and local control (LRC) were 11.5, 3.5, and 5.5 months, respectively. The 2-year OS, PFS, and LRC rates were 39%, 24%, and 53%, respectively. Statistical analysis identified presence of gross disease and interval to reirradiation as negative predictors of survival outcomes on both univariate and multivariate analyses (p < 0.05). On multivariate analysis, tumor volume was a negative predictor of survival outcomes (p < 0.05). Long-term toxicity analysis revealed four patients in the reirradiated group with soft tissue necrosis, which correlated with the cumulative dose (p = 0.01).  CONCLUSION: Our data suggest that SBRT is a reasonable treatment option for reirradiation of salivary gland tumors, but further studies are warranted.
authors: Department of Radiation Medicine, Georgetown University Hospital, 3800 Reservoir Rd., NW, Washington, DC 20007 USA.
authors: Sana D
authors: SD
authors: Karam
authors: James W
authors: JW
authors: Snider
authors: Hongkun
authors: H
authors: Wang
authors: Margaux
authors: M
authors: Wooster
authors: Christopher
authors: C
authors: Lominska
authors: John
authors: J
authors: Deeken
authors: Kenneth
authors: K
authors: Newkirk
authors: Bruce
authors: B
authors: Davidson
authors: K William
authors: KW
authors: Harter
keywords: Reirradiation; Salivary malignancies; Stereotactic radiosurgery; Toxicity