title: Complete genome sequence of Treponema pallidum strain DAL-1.
abstract: Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.
authors: Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors: Marie
authors: M
authors: Zobaníková
authors: Pavol
authors: P
authors: Mikolka
authors: Darina
authors: D
authors: Cejková
authors: Petra
authors: P
authors: Pospíšilová
authors: Lei
authors: L
authors: Chen
authors: Michal
authors: M
authors: Strouhal
authors: Xiang
authors: X
authors: Qin
authors: George M
authors: GM
authors: Weinstock
authors: David
authors: D
authors: Smajs
keywords: Spirochaetaceae; Treponema pallidum; syphilis