title: Nanoamplifiers synthesized from gadolinium and gold nanocomposites for magnetic resonance imaging.
abstract: We have synthesized an efficient and highly sensitive nanoamplifier composed of gadolinium-doped silica nanoparticles and gold nanoparticles (AuNPs). Magnetic resonance imaging (MRI) in vitro and in vivo assays revealed enhancement of signal sensitivity, which may be explained by electron transfer between water and gadolinium-doped nanoparticles, apparent in the presence of gold. In vitro and in vivo evaluation demonstrated nanoamplifier incurred minimal cytotoxicity and immunotoxicity, increased stability, and gradual excretion patterns. Tumor targeted properties were preliminarily determined when the nanoamplifier was injected into mouse models of colon cancer liver metastasis. Furthermore, although AuNPs departed from the nanoamplifiers in specific mice tissues, optical and magnetic resonance imaging was efficient, especially in metastatic tumors. These assays validate our nanoamplifier as an effective MRI signal enhancer with sensitive cancer diagnosis potential.
authors: State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, People's Republic of China.
authors: Xiumei
authors: X
authors: Tian
authors: Yuanzhi
authors: Y
authors: Shao
authors: Haoqiang
authors: H
authors: He
authors: Huan
authors: H
authors: Liu
authors: Yingying
authors: Y
authors: Shen
authors: Wenlin
authors: W
authors: Huang
authors: Li
authors: L
authors: Li
mesh_terms: D000327:Adsorption; D000818:Animals; D001682:Biological Availability; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D005682:Gadolinium / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D006046:Gold / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D006207:Half-Life; D006801:Humans; D007109:Immunity / Q000187:drug effects; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D053761:Nanocomposites / Q000737:chemistry / Q000633:toxicity; D009369:Neoplasms / Q000175:diagnosis; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; D006046:Gold; D005682:Gadolinium