title: Mitochondria as a pharmacological target: magnum overview.
abstract: Mitochondria, responsible for energy metabolism within the cell, act as signaling organelles. Mitochondrial dysfunction may lead to cell death and oxidative stress and may disturb calcium metabolism. Additionally, mitochondria play a pivotal role in cardioprotective phenomena and a variety of neurodegenerative disorders ranging from Parkinson's to Alzheimer's disease. Mitochondrial DNA mutations may lead to impaired respiration. Hence, targeting the mitochondria with drugs offers great potential for new therapeutic approaches. The purpose of this overview is to present the recent state of knowledge concerning the interactions of various substances with mitochondria.
authors: Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Warsaw, Poland. a.kajma@nencki.gov.pl
authors: Anna
authors: A
authors: Olszewska
authors: Adam
authors: A
authors: Szewczyk
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000975:Antioxidants / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D004272:DNA, Mitochondrial / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004579:Electron Transport / Q000187:drug effects* / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007476:Ionophores / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009154:Mutation; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D026902:Potassium Channel Blockers / Q000494:pharmacology; D014475:Uncoupling Agents / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D004272:DNA, Mitochondrial; D004791:Enzyme Inhibitors; D007476:Ionophores; D018696:Neuroprotective Agents; D026902:Potassium Channel Blockers; D014475:Uncoupling Agents