title: Acoustically controlled enhancement of molecular sensing to assess oxidative stress in cells.
abstract: We demonstrate a microfluidic platform for the controlled aggregation of colloidal silver nanoparticles using surface acoustic waves (SAWs), enabling surface enhanced Raman scattering (SERS) analysis of oxidative damage in cells. We show that by varying the frequency and the power of the acoustic energy, it is possible to modulate the aggregation of the colloid within the sample and hence to optimise the SERS analysis.
authors: Division of Biomedical Engineering, University of Glasgow, Oakfield Avenue, Glasgow, G12 8LT, UK.
authors: Julien
authors: J
authors: Reboud
authors: Craig
authors: C
authors: Auchinvole
authors: Christopher D
authors: CD
authors: Syme
authors: Rab
authors: R
authors: Wilson
authors: Jonathan M
authors: JM
authors: Cooper
mesh_terms: D000162:Acoustics; D006801:Humans; D019169:Jurkat Cells; D053768:Metal Nanoparticles; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D018384:Oxidative Stress; D012834:Silver / Q000737:chemistry / Q000378:metabolism; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D012834:Silver