title: Infantile osteomyelitis secondary to malignant osteopetrosis.
abstract: Osteopetrosis (OP) is a rare congenital disorder (present at birth) in which the bones become over dense. This results from an imbalance between the formation of bone and the resorption of the bone. Thickening of the bones which become abnormally dense due to an inherited defect in bone resorption, the process in which old bone is broken down and removed so that new bone can be added to the skeleton. Osteoclasts are the cells responsible for bone resorption. In osteopetrosis the osteoclasts do not perform normally. This flaw in bone resorption results in bones that are abnormally dense, yet are fragile and easily broken. Osteopetrosis is also known as Albers-Schonberg disease, generalized congenital osteosclerosis, ivory bones, marble bones, osteosclerosis fragilis generalisata. In this article, we have described about the diagnosis and medical and surgical management of osteopetrosis reported case to our hospital.
authors: Department of Oral and Maxillofacial Pathology, Modern Dental College and Research Centre, Indore, 453112 Madhya Pradesh India.
authors: Sunita
authors: S
authors: Managutti
authors: Anil
authors: A
authors: Managutti
authors: Michael
authors: M
authors: Pragasm
keywords: Marble bone disease; Osteomyelitis; Osteopetrosis