title: [Serrated polyps of the duodenum. Three cases with immunohistological and molecular pathological findings].
abstract: We report on three cases of serrated polyps of the duodenum which were incidental endoscopic findings in three male patients with a median age of 70 years (range 63-84 years). Architecturally the histological findings in cases 1 and 2 were similar to hyperplastic polyps of the colon. In case 3 there was a low grade intraepithelial neoplasia which covered the whole polyp. This polyp relapsed after 2 years with similar histological findings. Immunohistochemically an increased proliferative activity was found in case 3 as well as associated overexpression of p16 (INK4a) and p53. No abnormal expression of MLH1 and β-catenin was found in any of the polyps. Molecular pathological analysis showed a BRAF mutation (V600E) in case 3. A wild type sequence in the KRAS gene was found in all polyps. In conclusion, serrated polyps should be included in the diagnostic spectrum of benign duodenal polyps.
authors: Pathologie München-Nord, Ernst-Platz-Strasse 2, Munich, Germany. sarbia@pathologie-muenchen.de
authors: M
authors: M
authors: Sarbia
authors: S
authors: S
authors: Jüttner
authors: M
authors: M
authors: Bettstetter
authors: R
authors: R
authors: Berndt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D002278:Carcinoma in Situ / Q000235:genetics / Q000473:pathology; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D004252:DNA Mutational Analysis; D004379:Duodenal Neoplasms / Q000235:genetics* / Q000473:pathology*; D004384:Duodenoscopy; D004386:Duodenum / Q000473:pathology; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D033162:Incidental Findings; D007413:Intestinal Mucosa / Q000473:pathology; D007417:Intestinal Polyps / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16; D016159:Tumor Suppressor Protein p53