title: Littoral cell angiosarcoma in a dog.
abstract: This report describes the microscopical and immunohistochemical characteristics of littoral cell angiosarcoma in a 12-year-old, neutered female, beagle dog. The dog succumbed to metastatic disease 3 months after diagnosis of a mid-splenic mass. The tumour was characterized by two histological patterns: anastomosing microvascular channels and microvascular papillary fronds. The neoplastic cells expressed both endothelial and histiocytic markers and were erythrophagocytic. Immunohistochemical findings consistent with malignancy were CD34 expression and high Ki67 nuclear immunoreactivity.
authors: University of Illinois, College of Veterinary Medicine, Department of Pathobiology, Urbana, IL 61802, USA. agal2@illinois.edu
authors: A
authors: A
authors: Gal
authors: J
authors: J
authors: Yamate
authors: H M
authors: HM
authors: Golbar
authors: K
authors: K
authors: Spoerer
authors: R
authors: R
authors: Fredrickson
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006391:Hemangioma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D006394:Hemangiosarcoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D013160:Splenic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
keywords: dog; immunohistochemistry; littoral cell angiosarcoma; spleen