title: Age-related skeletal muscle mass loss and physical performance in Taiwan: implications to diagnostic strategy of sarcopenia in Asia.
abstract: OBJECTIVE
  Skeletal muscle loss is a common feature of aging, and is associated with unfavorable outcomes. Although several indexes of skeletal muscle mass measurement have been developed, the most optimal index for sarcopenia diagnosis among Asian populations has remained unclear. The present study aimed to evaluate the relationship between skeletal muscle mass and physical performance among community-dwelling people in Taiwan.
  
  
  METHODS
  Data of the I-Lan Longitudinal Aging Study (ILAS) were retrieved for study. Comparisons between demographic profiles, physical performance and skeletal muscle mass (measured by dual-energy X-ray absorptiometry) were carried out. Skeletal muscle mass expressed by lean body mass divided by squared height (LBM/ht(2) ), appendicular muscle mass divided by squared height (ASM/ht(2) ) and percent skeletal muscle index (SMI%) were compared between measurements of physical performance.
  
  
  RESULTS
  Overall, the data of 532 participants (mean age 64.6 ± 9.5 years, male 53.0%) were retrieved for analysis. Age was associated with poorer physical performance, and decreased ASM/ht(2) and LBM/ht(2) , but not SMI%. Skeletal muscle mass (SMI%) was less significantly related to slow walking speed than ASM/ht(2) in men. In women, all three muscle indexes showed no significant association between slow walking speed. In contrast, low handgrip strength was strongly associated with decreased skeletal muscle mass (measured by ASM/ht(2) and LBM/ht(2) , but not SMI%) in both men and women.
  
  
  CONCLUSIONS
  Skeletal muscle mass was significantly associated with handgrip strength along with aging, but the association of skeletal muscle mass and walking speed was less significant. In sarcopenia diagnosis among Asian populations, ASM/ht(2) should be the most suitable index for skeletal muscle mass measurements, and physical performance should be measured universally beyond measurements of skeletal muscle mass.
authors: Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors: Li-Kuo
authors: LK
authors: Liu
authors: Wei-Ju
authors: WJ
authors: Lee
authors: Chien-Liang
authors: CL
authors: Liu
authors: Liang-Yu
authors: LY
authors: Chen
authors: Ming-Hsien
authors: MH
authors: Lin
authors: Li-Ning
authors: LN
authors: Peng
authors: Liang-Kung
authors: LK
authors: Chen
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D001823:Body Composition; D005260:Female; D018737:Hand Strength; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D055948:Sarcopenia / Q000175:diagnosis* / Q000503:physiopathology*; D013624:Taiwan
keywords: aging; appendicular muscle mass; body composition; lean body mass; sarcopenia; skeletal muscle mass