title: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis: the Danish experience.
abstract: OBJECTIVE
  Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment option with curative intent for selected patients with peritoneal carcinomatosis (PC). CRS and HIPEC have been implemented in Denmark at a single centre since 2006. Six years of data on these patients were analysed.
  
  
  METHODS
  Patients with PC from colorectal or appendiceal cancer, pseudomyxoma peritonei or malignant peritoneal mesothelioma referred to the single national HIPEC centre were prospectively registered from June 2006 to July 2012. Morbidity, 30-day mortality and long-term survival of patients who underwent CRS and HIPEC were analysed.
  
  
  RESULTS
  In total, 80 patients underwent CRS and HIPEC. PC originated from colorectal cancer in 34 patients, pseudomyxoma peritonei in 29, appendiceal cancer in 13 and malignant peritoneal mesothelioma in four patients. Thirty-two patients had one or more complications during the hospital stay. The 30-day mortality rate was 1.3%. The predicted 2-, 3- and 5-year survival was 60%, 47% and 38% in patients with PC from colorectal cancer, and 100%, 93% and 73% in pseudomyxoma peritonei patients.
  
  
  CONCLUSIONS
  CRS and HIPEC is a safe procedure when centralized as in Denmark. Favourable long-term outcome was achieved in selected patients with PC from colorectal cancer and pseudomyxoma peritonei. Short-term and long-term outcomes were comparable to results from international centres.
authors: Department of Surgery, Aarhus University Hospital THG, Aarhus, Denmark. lene.h.iversen@dadlnet.dk
authors: L H
authors: LH
authors: Iversen
authors: P C
authors: PC
authors: Rasmussen
authors: R
authors: R
authors: Hagemann-Madsen
authors: S
authors: S
authors: Laurberg
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D001063:Appendiceal Neoplasms / Q000473:pathology; D002277:Carcinoma / Q000556:secondary / Q000628:therapy*; D015179:Colorectal Neoplasms / Q000473:pathology; D003131:Combined Modality Therapy; D003718:Denmark; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007263:Infusions, Parenteral; D007414:Intestinal Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D008654:Mesothelioma / Q000628:therapy*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D010534:Peritoneal Neoplasms / Q000556:secondary / Q000628:therapy*; D010537:Peritoneum / Q000601:surgery*; D011553:Pseudomyxoma Peritonei / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin
keywords: Cytoreductive surgery; HIPEC; peritoneal carcinomatosis; pseudomyxoma peritonei; survival; treatment outcome