title: Single-walled carbon nanotube-based near-infrared optical glucose sensors toward in vivo continuous glucose monitoring.
abstract: This article reviews research efforts on developing single-walled carbon nanotube (SWNT)-based near-infrared (NIR) optical glucose sensors toward long-term in vivo continuous glucose monitoring (CGM). We first discuss the unique optical properties of SWNTs and compare SWNTs with traditional organic and nanoparticle fluorophores regarding in vivo glucose-sensing applications. We then present our development of SWNT-based glucose sensors that use glucose-binding proteins and boronic acids as a high-affinity molecular receptor for glucose and transduce binding events on the receptors to modulate SWNT fluorescence. Finally, we discuss opportunities and challenges in translating the emerging technology of SWNT-based NIR optical glucose sensors into in vivo CGM for practical clinical use.
authors: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors: Kyungsuk
authors: K
authors: Yum
authors: Thomas P
authors: TP
authors: McNicholas
authors: Bin
authors: B
authors: Mu
authors: Michael S
authors: MS
authors: Strano
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation* / Q000379:methods; D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D037742:Nanotubes, Carbon
chemical_list: D037742:Nanotubes, Carbon