title: Memory CD8⁺ T cell protection.
abstract: Memory CD8⁺ T cells play an essential role in controlling pathogenic infections. Therefore generating protective memory CD8⁺ T cells by vaccination is an attractive strategy for preventing and treating a variety of human diseases. Understanding what comprises a protective memory CD8⁺ T cell response will help optimize vaccine-induced CD8⁺ T cell immunity. Here we discuss essential antiviral effector functions and highlight how recall expansion of memory CD8⁺ T cells may affect the primary response.
authors: Immune Cell Development and Host Defense, The Research Institute of Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. Sanda.Remakus@fccc.edu
authors: Sanda
authors: S
authors: Remakus
authors: Luis J
authors: LJ
authors: Sigal
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000821:virology; D049109:Cell Proliferation; D006801:Humans; D007156:Immunologic Memory; D012899:Smallpox / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D014611:Vaccination; D012901:Variola virus / Q000276:immunology