title: Status of human germ cell differentiation from pluripotent stem cells.
abstract: Historically, the quality of life of infertile couples has been greatly diminished by the loss of opportunity to conceive. However, beginning with the advent of IVF in the late 1970s, novel clinical interventions have greatly changed the outlook for those with severe forms of infertility. Yet, in cases in which the quality and quantity of germ cells are most compromised, there are few options. In the present paper, the current status of germ cell development from stem cells is reviewed in light of potential utility for basic science and clinical applications.
authors: Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305-5463, USA. reneer@stanford.edu
authors: Renee A Reijo
authors: RA
authors: Pera
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D003584:Cytological Techniques / Q000379:methods*; D005854:Germ Cells / Q000166:cytology* / Q000254:growth & development*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D007246:Infertility / Q000503:physiopathology / Q000628:therapy*; D051379:Mice; D008954:Models, Biological; D050814:Octamer Transcription Factor-3 / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods
chemical_list: D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human