title: Comparative analysis of intralesional sclerotherapy with sodium tetradecyl sulfate versus bleomycin in the management of low flow craniofacial soft tissue vascular lesions.
abstract: OBJECTIVE
  Comparison of the efficacy of bleomycin over sodium tetradecyl sulfate (STS) when given intralesionally in the treatment of oral and maxillofacial venous malformation.
  
  
  METHODS
  16 patients with venous malformation in craniofacial region were randomly divided into two groups of eight. Group 1 was given intralesional injection of bleomycin and group 2 was injected with STS. All the cases were evaluated for a minimum period of two and a maximum of 3 years.
  
  
  RESULTS
  Efficacy of bleomycin was found to be superior to STS, when used as intralesional sclerotherapic agent. Most of the vascular lesions of group 1 resolved after first dose giving a cure rate of 87.5% and no recurrence was observed. Group 2 patients however, required 4-6, a mean of five repeated dosage of intralesional STS before their lesions started to resolve and three patients reported with recurrence within 2 years, giving an overall effective response rate of 62.5%.
  
  
  CONCLUSIONS
  Bleomycin under selected conditions appears to be an excellent therapy for treating soft tissue vascular lesions of low flow nature in craniofacial region. Predictable results were obtained with a high success rate. No systemic or pulmonary complications occurred.
authors: Department of Oral & MaxilloFacial Surgery, Maharanapratap Dental College & Hospital, Flat No. 203, Ashirwad complex, Nawabganj sabji mandi, Kanpur, 208002 India.
authors: Hemant
authors: H
authors: Bajpai
authors: Sarika
authors: S
authors: Bajpai
keywords: Maxillofacial; Vascular; Venous malformation