title: Successful treatment of an unresectable inflammatory myofibroblastic tumor of the frontal bone using a cyclooxygenase-2 inhibitor and methotrexate.
abstract: Inflammatory myofibroblastic tumor (IMT) is a disease characterized by tumorous lesions consisting of myofibroblastic spindle cells and inflammatory cells that occur primarily in the soft tissues and viscera of children and young adults. Total excision is the most effective therapy. Steroids have been used to treat unresectable lesions with some success. We herein report a case of IMT involving the frontal bone accompanied by pachymeningitis. The tumor was characterized by an aggressive clinical course that was refractory to prednisolone. Performing total excision seemed difficult. Celecoxib and methotrexate were effective treatments. Our experience suggests the efficacy of celecoxib and methotrexate as alternatives for treating unresectable IMT.
authors: Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.
authors: Fumiko
authors: F
authors: Kusunoki-Nakamoto
authors: Takashi
authors: T
authors: Matsukawa
authors: Masaki
authors: M
authors: Tanaka
authors: Toji
authors: T
authors: Miyagawa
authors: Tomotaka
authors: T
authors: Yamamoto
authors: Jun
authors: J
authors: Shimizu
authors: Masako
authors: M
authors: Ikemura
authors: Junji
authors: J
authors: Shibahara
authors: Shoji
authors: S
authors: Tsuji
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D005260:Female; D005624:Frontal Bone / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D008727:Methotrexate