title: [Dynamics of chromosomal aberrations in primates subject to continuous and fractionated gamma-irradiation by equally effective residual doses].
abstract: The paper deals with a comparative study of two regimens of Macaca mulatta continuous 2-week gamma- and double fractionated acute irradiation by the total absorbed doses of 250 and 132 cGy, respectively; data about chromosomal aberration rates in peripheral lymphocytes were correlated. Based on calculations it was hypothesized that, regardless of regimen, by day-12 of irradiation the effective residual dose would be same, i.e. approximately 100 cGy. Analysis of instable aberration chromosomes showed similarity of the effect of gamma-irradiation by 137Cs at earlier time points (on days 2-21). In primates with the gamma-irradiation profile close to chronic (Gamma 25) the total rate of chromosomal aberrations and rate of radiation markers remain high, whereas animals exposed to fractionated radiation (Gamma 66) displayed a statistically significant (p < 0.05) reduction in cytogenetic parameters on days 36, 50 and 85. Cytogenetic analysis of peripheral lymphocytes permits the conclusion that though markedly different in dose values and rates, both regimens produce an essentially equal early damaging effect.
authors: L A
authors: LA
authors: Repina
authors: S V
authors: SV
authors: Vorozhtsova
authors: A N
authors: AN
authors: Abrosimova
authors: N N
authors: NN
authors: Novitskaia
authors: G P
authors: GP
authors: Snigireva
authors: A A
authors: AA
authors: Ivanov
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations / Q000528:radiation effects*; D020732:Cytogenetic Analysis; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D005720:Gamma Rays / Q000009:adverse effects*; D008214:Lymphocytes / Q000528:radiation effects; D008253:Macaca mulatta; D008297:Male; D011833:Radiation Injuries, Experimental / Q000235:genetics* / Q000473:pathology