title: Rapid-antigen detection tests for group a streptococcal pharyngitis: revisiting false-positive results using polymerase chain reaction testing.
abstract: We investigated mechanisms of the false-positive test results on rapid-antigen detection test (RADT) for group A Streptococcal (GAS) pharyngitis. Most RADT false-positives (76%) were associated with polymerase chain reaction-positive GAS results, suggesting that RADT specificity could be considered close to 100%. Finding that 61% of GAS culture-negative but RADT-positive cases were positive on both GAS polymerase chain reaction and Staphylococcus aureus testing, we posit bacterial inhibition as causative.
authors: INSERM, UMR S953, Epidemiological Research Unit on Perinatal Health and Women's and Children's Health, Paris, France. jeremie.cohen@inserm.fr
authors: Jérémie F
authors: JF
authors: Cohen
authors: Robert
authors: R
authors: Cohen
authors: Philippe
authors: P
authors: Bidet
authors: Corinne
authors: C
authors: Levy
authors: Patrice
authors: P
authors: Deberdt
authors: Camille
authors: C
authors: d'Humières
authors: Sandrine
authors: S
authors: Liguori
authors: François
authors: F
authors: Corrard
authors: Franck
authors: F
authors: Thollot
authors: Patricia
authors: P
authors: Mariani-Kurkdjian
authors: Martin
authors: M
authors: Chalumeau
authors: Edouard
authors: E
authors: Bingen
mesh_terms: D000293:Adolescent; D000942:Antigens, Bacterial / Q000032:analysis* / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005189:False Positive Reactions; D006801:Humans; D010612:Pharyngitis / Q000175:diagnosis* / Q000382:microbiology; D010614:Pharynx / Q000382:microbiology*; D016133:Polymerase Chain Reaction / Q000379:methods; D012680:Sensitivity and Specificity; D013211:Staphylococcus aureus / Q000276:immunology / Q000302:isolation & purification*; D013290:Streptococcal Infections / Q000175:diagnosis*; D013297:Streptococcus pyogenes / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D000942:Antigens, Bacterial