title: Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line.
abstract: Lung cancer is one of the leading causes of death worldwide. We investigated the molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. Acacia honey inhibited cells proliferation, arrested G0/G1 phase, stimulated cytokines, calcium ion release as well as suppressed p53 and Bcl-2 expression in a dose-dependent manner. We proposed that the molecular mechanism of the antiproliferation potential of Acacia honey on NCI-H460 cell line is due to cell cycle arrest, stimulation of cytokines and calcium ion as well as downregulation of Bcl-2 and p53 genes.
authors: Department of Biochemistry, University of Ibadan, Ibadan, Oyo State, Nigeria. amachida31@gmail.com
authors: Muhammad
authors: M
authors: Aliyu
authors: Oyeronke A
authors: OA
authors: Odunola
authors: Ahsana D
authors: AD
authors: Farooq
authors: Huma
authors: H
authors: Rasheed
authors: Ahmed M
authors: AM
authors: Mesaik
authors: Muhammad I
authors: MI
authors: Choudhary
authors: Iffat S
authors: IS
authors: Channa
authors: Salman A
authors: SA
authors: Khan
authors: Ochuko L
authors: OL
authors: Erukainure
mesh_terms: D000045:Acacia; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D059585:G1 Phase Cell Cycle Checkpoints / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D019254:Genes, bcl-2; D016158:Genes, p53; D006722:Honey; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines; D002118:Calcium