title: High expression of cyclic nucleotide phosphodiesterase 7B mRNA predicts poor prognosis in mantle cell lymphoma.
abstract: In order to determine the relationship between expression of cyclic nucleotide phosphodiesterase isoform 7B (PDE7B) and mantle cell lymphoma (MCL) progression, PDE7B mRNA expression was measured by qRT-PCR in 21 untreated MCL patients with bone marrow involvement and 20 healthy donors. The expression level of PDE7B was markedly higher in MCL patients compared with normal controls (P=0.001), and the higher level of PDE7B expression was associated with unfavorable cytogenetic characteristics in MCL. It was showed that higher expression of PDE7B might be a novel unfavorable prognostic indicator in MCL, which possess important clinical significance.
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
authors: Cheng
authors: C
authors: Fang
authors: Hua-Jie
authors: HJ
authors: Dong
authors: Zhi-Jian
authors: ZJ
authors: Zou
authors: Lei
authors: L
authors: Fan
authors: Li
authors: L
authors: Wang
authors: Run
authors: R
authors: Zhang
authors: Ji
authors: J
authors: Xu
authors: Wei
authors: W
authors: Xu
authors: Jian-Yong
authors: JY
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000201:enzymology / Q000473:pathology; D054708:Cyclic Nucleotide Phosphodiesterases, Type 7 / Q000096:biosynthesis* / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000201:enzymology* / Q000235:genetics / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D011237:Predictive Value of Tests; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D012334:RNA, Neoplasm / Q000096:biosynthesis* / Q000235:genetics; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D054708:Cyclic Nucleotide Phosphodiesterases, Type 7; C517463:PDE7B protein, human