title: Time series analysis of onchocerciasis data from Mexico: a trend towards elimination.
abstract: BACKGROUND
  In Latin America, there are 13 geographically isolated endemic foci distributed among Mexico, Guatemala, Colombia, Venezuela, Brazil and Ecuador. The communities of the three endemic foci found within Mexico have been receiving ivermectin treatment since 1989. In this study, we predicted the trend of occurrence of cases in Mexico by applying time series analysis to monthly onchocerciasis data reported by the Mexican Secretariat of Health between 1988 and 2011 using the software R.
  
  
  RESULTS
  A total of 15,584 cases were reported in Mexico from 1988 to 2011. The data of onchocerciasis cases are mainly from the main endemic foci of Chiapas and Oaxaca. The last case in Oaxaca was reported in 1998, but new cases were reported in the Chiapas foci up to 2011. Time series analysis performed for the foci in Mexico showed a decreasing trend of the disease over time. The best-fitted models with the smallest Akaike Information Criterion (AIC) were Auto-Regressive Integrated Moving Average (ARIMA) models, which were used to predict the tendency of onchocerciasis cases for two years ahead. According to the ARIMA models predictions, the cases in very low number (below 1) are expected for the disease between 2012 and 2013 in Chiapas, the last endemic region in Mexico.
  
  
  CONCLUSIONS
  The endemic regions of Mexico evolved from high onchocerciasis-endemic states to the interruption of transmission due to the strategies followed by the MSH, based on treatment with ivermectin. The extremely low level of expected cases as predicted by ARIMA models for the next two years suggest that the onchocerciasis is being eliminated in Mexico. To our knowledge, it is the first study utilizing time series for predicting case dynamics of onchocerciasis, which could be used as a benchmark during monitoring and post-treatment surveillance.
authors: Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa, Tamaulipas, México.
authors: Edgar E
authors: EE
authors: Lara-Ramírez
authors: Mario A
authors: MA
authors: Rodríguez-Pérez
authors: Miguel A
authors: MA
authors: Pérez-Rodríguez
authors: Monsuru A
authors: MA
authors: Adeleke
authors: María E
authors: ME
authors: Orozco-Algarra
authors: Juan I
authors: JI
authors: Arrendondo-Jiménez
authors: Xianwu
authors: X
authors: Guo
mesh_terms: D000871:Anthelmintics / Q000627:therapeutic use; D060740:Disease Eradication; D019353:Endemic Diseases; D006801:Humans; D015994:Incidence; D007559:Ivermectin / Q000627:therapeutic use; D008800:Mexico / Q000453:epidemiology; D009855:Onchocerciasis / Q000188:drug therapy / Q000453:epidemiology*; D015995:Prevalence
chemical_list: D000871:Anthelmintics; D007559:Ivermectin