title: The mechanism of tissue-restricted antigen gene expression by AIRE.
abstract: The autoimmune regulator is a critical transcription factor for generating central tolerance in the thymus. Recent studies have revealed how the autoimmune regulator targets many otherwise tissue-restricted Ag genes to enable negative selection of autoreactive T cells.
authors: Department of Virology, Haartman Institute, Helsinki University Central Hospital, University of Helsinki, FIN-00014 Helsinki, Finland.
authors: Kristina
authors: K
authors: Zumer
authors: Kalle
authors: K
authors: Saksela
authors: B Matija
authors: BM
authors: Peterlin
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics; D000818:Animals; D000941:Antigens / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D017124:Conserved Sequence / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D016884:Polyendocrinopathies, Autoimmune / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D025941:Protein Interaction Mapping / Q000379:methods; D014018:Tissue Distribution / Q000235:genetics / Q000276:immunology; D014157:Transcription Factors / Q000737:chemistry / Q000502:physiology*; D000096927:AIRE Protein
chemical_list: D000941:Antigens; D014157:Transcription Factors; D000096927:AIRE Protein