title: Assessment of allodynia relief by tissue-protective molecules in a rat model of nerve injury-induced neuropathic pain.
abstract: Neuropathic pain following nerve injury is a chronic disease characterized by allodynia and hyperalgesia of either mechanical or thermal origin. The mechanism underlying this disease is poorly understood leading to pharmacologic and physiotherapeutic control that is often insufficient. In this chapter, we describe a method to induce nerve injury in rats to create a robust animal model for studying neuropathic pain. Additionally we describe a method to follow up on animals in the process of testing treatments for efficacy in alleviating allodynia by testing for both mechanical and thermal allodynia with reproducible results.
authors: Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Maarten
authors: M
authors: Swartjes
authors: Marieke
authors: M
authors: Niesters
authors: Albert
authors: A
authors: Dahan
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006930:Hyperalgesia / Q000188:drug therapy*; D009437:Neuralgia / Q000188:drug therapy*; D009842:Oligopeptides / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009842:Oligopeptides; C576178:cibinetide