title: Pattern recognition analysis of proteins using DNA-decorated catalytic gold nanoparticles.
abstract: A label-free protein analysis strategy is based on patterns of gold nanoparticle (AuNP) growth. AuNPs pretreated with different oligonucleotides are challenged with various proteins. After Au reduction, the colorimetric patterns are processed with linear discriminant analysis. This method discriminates different proteins, or one protein of different concentrations, in mixed samples or even serum and urine.
authors: College of Life Sciences, Sichuan University, Chengdu 610064, China; Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
authors: Xiafeng
authors: X
authors: Yang
authors: Jiang
authors: J
authors: Li
authors: Hao
authors: H
authors: Pei
authors: Di
authors: D
authors: Li
authors: Yun
authors: Y
authors: Zhao
authors: Jimin
authors: J
authors: Gao
authors: Jianxin
authors: J
authors: Lu
authors: Jiye
authors: J
authors: Shi
authors: Chunhai
authors: C
authors: Fan
authors: Qing
authors: Q
authors: Huang
mesh_terms: D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry
chemical_list: D006046:Gold; D004247:DNA
keywords: biosensors; gold nanoparticles; oligonucleotides; pattern recognition; proteins