title: Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives.
abstract: Axonal myelination is an essential process for normal functioning of the vertebrate central nervous system. Proper formation of myelin sheaths around axons depends on the timely differentiation of oligodendrocytes. This differentiation occurs on a predictable schedule both in culture and during development. However, the timing mechanisms for oligodendrocyte differentiation during normal development have not been fully uncovered. Recent studies have identified a large number of regulatory factors, including cell-intrinsic factors and extracellular signals, that could control the timing of oligodendrocyte differentiation. Here we provide a mechanistic and critical review of the timing control of oligodendrocyte differentiation.
authors: Institute of Developmental and Regenerative Biology, College of Life Sciences, Hangzhou Normal University, Hangzhou 310018, China.
authors: Hao
authors: H
authors: Huang
authors: Xiao-Feng
authors: XF
authors: Zhao
authors: Kang
authors: K
authors: Zheng
authors: Mengsheng
authors: M
authors: Qiu
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology; D006801:Humans; D004676:Myelin Basic Protein / Q000187:drug effects / Q000378:metabolism; D009186:Myelin Sheath / Q000502:physiology; D009836:Oligodendroglia / Q000502:physiology*; D013997:Time Factors
chemical_list: D004676:Myelin Basic Protein