title: Inhibition of delta-like ligand 4 decreases Th1/Th17 response in a mouse model of multiple sclerosis.
abstract: Notch is a family of receptors involved in the differentiation of several tissues, including the central nervous system and the immune system. One of the Notch ligands, delta-like 4 (Dll4), has been implicated in the differentiation of Th1 cells and the development of Th17 responses, which are involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis. Our results show that a single administration of an anti-Dll4 antibody is not enough to avoid the development of EAE or to ameliorate the already established clinical signs, despite the treatment reduces the proliferative T cell responses and decreases Th1/Th17 immune responses.
authors: Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (CEM-Cat), Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Ps. Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
authors: Herena
authors: H
authors: Eixarch
authors: M José
authors: MJ
authors: Mansilla
authors: Carme
authors: C
authors: Costa
authors: Steve L
authors: SL
authors: Kunkel
authors: Xavier
authors: X
authors: Montalban
authors: Núria
authors: N
authors: Godessart
authors: Carmen
authors: C
authors: Espejo
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use; D049109:Cell Proliferation; D016207:Cytokines / Q000096:biosynthesis; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D005260:Female; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D008565:Membrane Proteins / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D058408:Th1-Th2 Balance / Q000187:drug effects*
chemical_list: D057134:Antibodies, Neutralizing; D016207:Cytokines; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C064045:delta protein