title: Healing properties of implants inserted concomitantly with anorganic bovine bone. A histomorphometric human study.
abstract: BACKGROUND
  The present prospective, randomized, double-blind study evaluated the bone-forming process around implants inserted simultaneously with anorganic bovine bone (ABB) in sinus grafting.
  
  
  METHODS
  A total of 18 threaded mini-implants with Osseotite (O) and Nanotite (N) surfaces were placed in seven patients (nine sites). After 12 months, the implants were retrieved and processed for histological analysis. A total of 18 cutting and grinding sections were investigated with bright-field light microscopy, circularly polarized light microscopy (CPLM), confocal scanning laser microscope (CSLM), and scanning electron microscope (SEM) with energy dispersive spectrometer (EDS).
  
  
  RESULTS
  The bone-to-implant contact rate in native crestal bone was 62.6 ± 0.4% for N implants and 54.3 ± 0.5% for the O implants (p = 0.001). The collagen fibre density, as assessed by CPLM, was 79.8 ± 6.0 nm for the N group and 74.6 ± 4.6 nm for the O group (p < 0.05). Line scan EDS starting from ABB to newly formed bone showed a decrease in calcium content and an increase of carbon while phosphorus content was constant.
  
  
  CONCLUSIONS
  While the N surface improved the peri-implant endosseous healing properties in the native bone, when compared to the O surface, it did not improve the healing properties in the bone-graft area.
authors: Department of Biomedical Sciences and Human Oncology, Dental School, University of Turin, Turin, Italy.
authors: G
authors: G
authors: Menicucci
authors: F
authors: F
authors: Mussano
authors: G
authors: G
authors: Schierano
authors: A
authors: A
authors: Rizzati
authors: M
authors: M
authors: Aimetti
authors: G
authors: G
authors: Gassino
authors: T
authors: T
authors: Traini
authors: S
authors: S
authors: Carossa
mesh_terms: D000328:Adult; D000818:Animals; D001857:Bone Matrix / Q000473:pathology / Q000601:surgery / Q000637:transplantation; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery / Q000637:transplantation; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology*; D011446:Prospective Studies; D059546:Sinus Floor Augmentation / Q000379:methods; D014945:Wound Healing / Q000502:physiology*
chemical_list: D015921:Dental Implants