title: Holoprosencephaly in clomiphene-induced pregnancy: a possible association? A case report and literature review.
abstract: Clomiphene is widely used for inducing ovulation. Evidence for congenital abnormalities, in particular central nervous system defects (CNS-D) and in babies born from clomiphene-induced pregnancies is conflicting. The authors report a case of holoprosencephalia (HPE) in a fetus delivered from a mother receiving clomiphene.
authors: Poison Control Centre and Teratology Information Service, Ospedali Riuniti, Bergamo, Italy. geleftheriou@ospedaliriuniti.bergamo.it
authors: G
authors: G
authors: Eleftheriou
authors: R
authors: R
authors: Butera
authors: L
authors: L
authors: Manzo
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects / Q000494:pharmacology; D005315:Fetal Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D016142:Holoprosencephaly / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D010062:Ovulation Induction; D016216:Ultrasonography, Prenatal
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene