title: Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans.
abstract: Studies focusing on the association of gene methylthioadenosine phosphorylase (MTAP) with the risk of coronary artery disease (CAD) and myocardial infarction (MI) are limited. In this study, we explored the effects of rs10118757 in MTAP gene on CAD and MI by performing association analysis in a Chinese Han population. rs10118757 was genotyped in 1007 CAD patients (including 338 MI patients) and 885 healthy controls. Allelic analysis showed that allele A of rs10118757 was associated with increased risk of CAD, with OR (95%CI)=1.193 (1.035-1.376), and P=0.015. After adjusted for age, BMI, gender, hypertension and smoking, rs10118757 was still significantly associated with CAD under additive and dominant models, with OR (95%CI)=1.252 (1.070-1.465), P=0.005, and OR (95%CI)=1.698 (1.168-2.467), P=0.006, respectively. Compared to additive model, dominant model may be the best-fitting model (P=6.63E-10 vs P=6.70E-10). As reported previously, rs10118757 was not associated with MI in the current study. Our study firstly reported that SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD.
authors: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), 74 Zhongshan Road 2, Guangzhou, 510080, China. lvxfei@mail3.sysu.edu.cn
authors: Xiaofei
authors: X
authors: Lv
authors: Yuan
authors: Y
authors: Zhang
authors: Shaoqi
authors: S
authors: Rao
authors: Dongfang
authors: D
authors: Su
authors: Dan
authors: D
authors: Feng
authors: Min
authors: M
authors: Wang
authors: Xinrui
authors: X
authors: Li
authors: Dan
authors: D
authors: Li
authors: Honghui
authors: H
authors: Guo
authors: Xiaoyu
authors: X
authors: Zuo
authors: Min
authors: M
authors: Xia
authors: Haimei
authors: H
authors: Ouyang
authors: Wenhua
authors: W
authors: Ling
authors: Jian
authors: J
authors: Qiu
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011683:Purine-Nucleoside Phosphorylase / Q000235:genetics*; D012307:Risk Factors
chemical_list: D011683:Purine-Nucleoside Phosphorylase; C021784:5'-methylthioadenosine phosphorylase
keywords: Association analysis; BMI; CABG; CAD; CI; Chinese Han population; DNA; IFN-γ; MAF; MI; MTAP; OR; PTCA; S-adenosylhomocysteine; S-adenosylmethionine; SAH; SAM; SNP; body mass index; confidence interval; coronary artery bypass graft surgery; coronary artery disease; deoxyribonucleic acid; interferon-γ; methylthioadenosine phosphorylase; minor allele frequency; myocardial infarction; odds ratio; percutaneous transluminal coronary angioplasty; single nucleotide polymorphism