title: The effect of gel structure on the kinetics of simulated gastrointestinal digestion of bovine β-lactoglobulin.
abstract: The structure and properties of protein gels depend on the conditions under which they are formed. Here, we assessed the susceptibility of protein to simulated gastro-duodenal digestion of weak gels with contrasting structures, produced from either purified bovine β-lactoglobulin (β-Lg) or whey protein isolate (WPI) at pH ranging from 2.5 to 6.5 and using different heating regimes. Gels formed close to the isoelectric point proved to be very resistant to simulated gastric digestion, with more than 85% of β-Lg remaining and in the simulated duodenal phase of digestion. The sample heated to 85 °C was most resistant with over 40% remaining. In the WPI sample heated to 85 °C, more than 20% of the original β-Lg content remained undigested after simulated gastro-duodenal proteolysis. These results suggest that firm particulate gels can persist longer in the GI tract and may be useful in inducing satiety and thus provide another weapon in the fight against obesity.
authors: Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK.
authors: Adam
authors: A
authors: Macierzanka
authors: Franziska
authors: F
authors: Böttger
authors: Laura
authors: L
authors: Lansonneur
authors: Rozenn
authors: R
authors: Groizard
authors: Anne-Sophie
authors: AS
authors: Jean
authors: Neil M
authors: NM
authors: Rigby
authors: Kathryn
authors: K
authors: Cross
authors: Nikolaus
authors: N
authors: Wellner
authors: Alan R
authors: AR
authors: Mackie
mesh_terms: D000818:Animals; D002417:Cattle; D004063:Digestion; D041981:Gastrointestinal Tract / Q000378:metabolism*; D005782:Gels / Q000737:chemistry* / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D007782:Lactoglobulins / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D005782:Gels; D007782:Lactoglobulins