title: Serum-based DNA methylation biomarkers in colorectal cancer: potential for screening and early detection.
abstract: Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States. Early identification and treatment of pre-cancerous colorectal lesions, or node-negative CRC are highly effective interventions that substantially reduce disease-specific mortality. Colonoscopy remains a highly effective primary screening tool based on its excellent diagnostic accuracy, and its ability to remove pre-cancerous lesions. However, the nature of the procedure limits compliance with colonoscopy intended for population-based CRC screening. A significant advance in the screening and care of these patients could be realized by blood-based biomarkers, which could accurately identify patients at-risk for CRC development whom might benefit from early and/or more frequent surveillance for disease. We reviewed and herein discuss the potential for serum based DNA methylation biomarkers for screening and early detection of CRC.
authors: 1. Department of Pathology and Laboratory Services, Walter Reed National Military Medical Center, Bethesda, MD, USA.
authors: Thomas
authors: T
authors: Summers
authors: Russell C
authors: RC
authors: Langan
authors: Aviram
authors: A
authors: Nissan
authors: Björn L D M
authors: BL
authors: Brücher
authors: Anton J
authors: AJ
authors: Bilchik
authors: Mladjan
authors: M
authors: Protic
authors: Martin
authors: M
authors: Daumer
authors: Itzhak
authors: I
authors: Avital
authors: Alexander
authors: A
authors: Stojadinovic
keywords: Biomarker: Early detection; Colorectal cancer; DNA methylation.; Screening; Serum