title: [Comparative studies of antihypoxic, neuroprotective and analgesic action of succinate-containing drugs].
abstract: Experiments with mice showed that, unlike reamberin (100 mg/kg), mexidol (100 mg/kg) and cytoflavin (1 ml/kg) act as antihypoxants in pressure and hermetic chambers but not in case of acute hemic and histotoxic hypoxia. Amtisol succinate (100 mg/kg), a reference antihypoxant, excels the other tried succinate-containing drugs in all models of acute hypoxia except the hermetic chamber. In addition, the neuroprotective action of mexidol (100 mg/kg/d) and cytoflavin (100 ml/kg/d) in rats with induced ischemic stroke which was stronger than that of reamberin and amtisol succinate (100 mg/kg/d). Besides, mexidol (100 mg/kg) but not cytoflavin (1 ml/kg), reamberin or amtisol succinate (100 mg/kg) had a distinct analgesic effect in rabbits. On the neuronal level, mexidol interacts with the GABAA- benzodiazepine-receptor complex in nearly 60% cells and inhibits ion currents through the NMDA-receptor ion channels in nearly 80% neurons.
authors: V V
authors: VV
authors: Iasnetsov
authors: E P
authors: EP
authors: Prosvirova
authors: E G
authors: EG
authors: Tsublova
authors: Vik V
authors: VV
authors: Iasnetsov
authors: V G
authors: VG
authors: Motin
authors: S K
authors: SK
authors: Karsanova
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D011817:Rabbits; D051381:Rats; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents; D013386:Succinates