title: A novel model approach for esophageal burns in rats: A comparison of three methods.
abstract: BACKGROUND
  Corrosive esophageal injury causes serious clinical problems. We aimed to create a new experimental esophageal burn model using a single catheter without a surgical procedure.
  
  
  METHODS
  We conducted the study with two groups of 12 male rats that fasted for 12 h before application. A modified Foley balloon catheter was inserted into the esophageal lumen. The control group was given 0.9% sodium chloride, while the experimental group was given 37.5% sodium hydroxide with the other part of the catheter. After 60s, esophagus was washed with distilled water. The killed rats were examined using histopathological methods after 28 days.
  
  
  RESULTS
  In comparison with the histopathological changes experienced by the study groups, the control groups were observed to have no pathological changes. Basal cell degeneration, dermal edema, and a slight increase in the keratin layer and collagen density of submucosa due to stenosis were all observed in the group subjected to esophageal corrosion.
  
  
  CONCLUSIONS
  A new burn model can thus, we believe, be created without the involvement of invasive laparoscopic surgery and general anesthesia. The burn in our experiment was formed in both the distal and proximal esophagus, as in other models; it can also be formed optionally in the entire esophagus.
authors: Department of Histology and Embryology, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors: Yildiray
authors: Y
authors: Kalkan
authors: Department of Histology and Embryology, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors: Levent
authors: L
authors: Tumkaya
authors: Department of Gastroenterology, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors: Remzi Adnan
authors: RA
authors: Akdogan
authors: Department of General Surgery, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors: Ahmet Fikret
authors: AF
authors: Yucel
authors: Department of Anesthesiology and Intensive Care, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors: Yakup
authors: Y
authors: Tomak
authors: Department of Pathology, Recep Tayyip Erdoğan Training and Research Hospital, Rize, Turkey.
authors: İbrahim
authors: İ
authors: Sehitoglu
authors: Department of General Surgery, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey pergelahmet@hotmail.com.
authors: Ahmet
authors: A
authors: Pergel
authors: Department of Thoracic Surgery, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors: Aysel
authors: A
authors: Kurt
mesh_terms: D000818:Animals; D002057:Burns, Chemical / Q000473:pathology*; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D002424:Caustics / Q000009:adverse effects*; D004195:Disease Models, Animal; D004947:Esophagus / Q000293:injuries* / Q000473:pathology*; D037901:Euthanasia, Animal; D008297:Male; D051381:Rats; D012965:Sodium Chloride; D012972:Sodium Hydroxide / Q000009:adverse effects*
chemical_list: D002424:Caustics; D012965:Sodium Chloride; D012972:Sodium Hydroxide
keywords: Esophageal burn; NaOH; caustic; rat model