title: Assessment of atherosclerosis in oncologic patients using ¹⁸F-fluoride PET/CT.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the prevalence, distribution, and relationship of (18)F-fluoride uptake and arterial calcification in oncologic patients using (18)F-fluoride PET/CT.
  
  
  METHODS
  Image data obtained from 29 oncologic patients undergoing whole-body (18)F-fluoride PET/CT were evaluated retrospectively. Arterial wall (18)F-fluoride uptake and calcification were analyzed both quantitatively and semiquantitatively in 8 patients with arterial (18)F-fluoride uptake.
  
  
  RESULTS
  Arterial (18)F-fluoride uptake was observed at 35 lesions in 8 (28 %) of the 29 patients, and calcification was observed at 345 lesions in the same patients. Five of the 8 patients had prostate cancer, and the remaining patients had hepatocellular carcinoma or malignant melanoma. In these 8 patients, the prevalence of both (18)F-fluoride uptake and calcification was highest in the abdominal aorta, followed by the descending thoracic aorta and the aortic arch. Colocalization of radiotracer accumulation and calcification could be observed in the 32 lesions (91 %) with arterial (18)F-fluoride uptake, and only the 3 lesions (9 %) with arterial (18)F-fluoride uptake were not colocalized with arterial calcification. The presence of both arterial radiotracer uptake and calcification was significantly associated with advancing age (P < 0.01).
  
  
  CONCLUSIONS
  Our results suggest that (18)F-fluoride PET/CT might be a useful modality for detecting active mineral deposition sites of atherosclerosis in oncologic patients.
authors: Department of Radiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume 830-0011, Japan. skur@med.kurume-u.ac.jp
authors: Seiji
authors: S
authors: Kurata
authors: Ukihide
authors: U
authors: Tateishi
authors: Kazuya
authors: K
authors: Shizukuishi
authors: Tomohiro
authors: T
authors: Yoneyama
authors: Ayako
authors: A
authors: Hino
authors: Hayato
authors: H
authors: Kaida
authors: Kiminori
authors: K
authors: Fujimoto
authors: Masatoshi
authors: M
authors: Ishibashi
authors: Tomio
authors: T
authors: Inoue
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D009928:Organ Specificity; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18