title: [Effects of strontium ranelate on mononuclear leukocyte culture].
abstract: Strontium ranelate (SR) effect on the functional parameters of human blood mononuclear leukocytes culture has been investigated. SR in concentrations of 2.9, 29, and 290 mg/ml produces a dose-dependent decrease in the activity of alkaline phosphatase and the content of calcium and potassium ions in supernatants. In concentrations of 2.9 and 29 mg/ml, SR decreases, while in a concentration of 290 mg/ml it increases the intercellular phosphate ion content. Fibroblast- and osteoblast-like cells, which are capable of regulating mineral compound of intercellular liquid, are SR cellular targets in human blood mononuclear leukocytes culture.
authors: I a
authors: Ia
authors: Khlusov
authors: A I
authors: AI
authors: Vengerovskiĭ
authors: K A
authors: KA
authors: Nechaev
authors: M V
authors: MV
authors: Dvornichenko
authors: I V
authors: IV
authors: Kulagina
authors: T V
authors: TV
authors: Saprina
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D017136:Ion Transport / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009942:Organometallic Compounds / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D050071:Bone Density Conservation Agents; D009942:Organometallic Compounds; D010710:Phosphates; D013876:Thiophenes; C081587:strontium ranelate; D000469:Alkaline Phosphatase; D011188:Potassium; D002118:Calcium