title: [Intraventricular yohimbine infusion induces noradrenergic changes in motor cerebral injured rats and enhances motor recovery].
abstract: BACKGROUND
  It has been proposed that noradrenaline is one of the neurotransmitters involved in the functional recovery. In this sense, it has been proposed that the alpha-2 noradrenergic receptors play an important role in the functional reinstatement.
  
  
  OBJECTIVE
  the aim of this work was to study the role of the alpha-2 noradrenergic receptors on the noradrenaline contents in cerebellum and pons of rats iron-injured in the motor cortex.
  
  
  METHODS
  Fifteen male Wistar rats were allocated in three groups: control (n = 5) with intracortical infusion of saline (0.9%), injured (n = 5) with intracortical infusion of dextran iron and intraventricular infusion of saline, and injured + yohimbine (alpha-2 receptor antagonist; n = 5) that received an intracortical infusion of dextran iron and also an intraventricular infusion of yohimbine. Motor behavior was assessed by means of the beam-walking paradigm. Three days after surgeries, the animals were sacrificed and the left and right sides of the pons and the cerebellar hemispheres were extracted. Tissues were prepared for noradrenaline analysis by means of high performance liquid chromatography.
  
  
  RESULTS
  We observed that the yohimbine-treated animals had a noradrenaline increase in the right side of the pons and a decrease in the right cerebellar hemisphere.
  
  
  CONCLUSIONS
  It is concluded that the blockage of the alpha-2 receptors leads to an increase of noradrenaline in the locus coeruleus, which retards the effects of the cerebral injury.
authors: Laboratorio de Neuroplasticidad, Instituto Nacional de Rehabilitación, D.F. México. higgo@prodigy.net.mx
authors: Rigoberto
authors: R
authors: González-Piña
authors: Alfonso
authors: A
authors: Alfaro-Rodríguez
authors: Antonio
authors: A
authors: Bueno-Nava
authors: Alberto
authors: A
authors: Ávila-Luna
mesh_terms: D058669:Adrenergic alpha-2 Receptor Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology*; D057967:Infusions, Intraventricular; D008297:Male; D009044:Motor Cortex / Q000187:drug effects* / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000187:drug effects*; D020127:Recovery of Function / Q000187:drug effects; D015016:Yohimbine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D058669:Adrenergic alpha-2 Receptor Antagonists; D011941:Receptors, Adrenergic; D015016:Yohimbine
keywords: Noradrenaline; cortical injury; functional recovery