title: Novel antibody to a carbonic anhydrase: patent evaluation of WO2011138279A1.
abstract: A novel antibody against human carbonic anhydrase XII (CA XII) was developed and characterized. Its specificity for the human CA XII isoform was assessed and its ability to inhibit CA XII was found about 40 times higher than acetazolamide, a well-known CA sulfonamide inhibitor. The antibody was shown to decrease cell proliferation in cultured A549 lung carcinoma cells, making it an interesting molecule for targeting and treating some forms of CA XII overexpressing tumors. The possibility of conjugating this antibody with fluorescent markers for diagnostic purposes or with toxins or anticancer drugs for treating purposes makes it an interesting molecule for developing new combined approaches for cancer treatment.
authors: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM1-UM2, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296, Montpellier Cedex, France. jean-yves.winum@univ-montp2.fr
authors: Jean-Yves
authors: JY
authors: Winum
authors: Clemente
authors: C
authors: Capasso
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000276:immunology / Q000494:pharmacology; D002257:Carbonic Anhydrase Inhibitors / Q000276:immunology / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000276:immunology*; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology; D010330:Patents as Topic
chemical_list: D000906:Antibodies; D000970:Antineoplastic Agents; D002257:Carbonic Anhydrase Inhibitors; D002256:Carbonic Anhydrases; C477378:carbonic anhydrase XII; D000086:Acetazolamide