title: An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine.
abstract: A significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation behavior, antibacterial activity and cellular response of chitosan/aloe vera-based membranes. The chitosan/aloe vera-based membranes that were developed displayed satisfactory degradation, roughness, wettability and mechanical properties. A higher antibacterial potency was displayed by the blended membranes. Moreover, in vitro assays demonstrated that these blended membranes have good cell compatibility with primary human dermal fibroblasts. The chitosan/aloe vera-based membranes might be promising wound dressing materials.
authors: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excelllence on Tissue Engineering and Regenerative Medicine, AvePark, Caldas das Taipas, 4806-909 Guimarães, Portugal. simonesilva@dep.uminho.pt
authors: S S
authors: SS
authors: Silva
authors: E G
authors: EG
authors: Popa
authors: M E
authors: ME
authors: Gomes
authors: M
authors: M
authors: Cerqueira
authors: A P
authors: AP
authors: Marques
authors: S G
authors: SG
authors: Caridade
authors: P
authors: P
authors: Teixeira
authors: C
authors: C
authors: Sousa
authors: J F
authors: JF
authors: Mano
authors: R L
authors: RL
authors: Reis
mesh_terms: D000504:Aloe / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005347:Fibroblasts / Q000166:cytology* / Q000502:physiology*; D048091:Guided Tissue Regeneration / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D023822:Tissue Engineering / Q000295:instrumentation; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D048271:Chitosan