title: Polycystic ovary syndrome and depression in New Zealand adolescents.
abstract: OBJECTIVE
  To determine whether adolescents with polycystic ovary syndrome (PCOS) are more depressed than adolescent girls in the community and to examine factors associated with depression.
  
  
  METHODS
  An observational study comparing clinical and community samples.
  
  
  METHODS
  Two specialist reproductive endocrine clinics in Auckland, New Zealand.
  
  
  METHODS
  102 girls aged 14-19 presenting for clinical assessment, fulfilling the Rotterdam consensus for PCOS. The comparison group was 1349 girls from a school-based survey of New Zealand youth.
  
  
  METHODS
  Clinically significant depression was identified by the long and short form Reynolds Adolescent Depression Scale. BMI, androgen levels, oral contraceptive use, objective symptom severity, age, ethnicity, and socioeconomic grouping were recorded.
  
  
  METHODS
  Clinically significant depression in the PCOS and community samples. Potential determinants of depression.
  
  
  RESULTS
  Clinically significant depression in adolescent girls with PCOS was not increased compared with the community sample (OR 1.3; 95%CI 0.7-2.7, P = .42). Within the PCOS cohort, depression was correlated with increased BMI (P = .01) and possibly acne (P = .08).
  
  
  CONCLUSIONS
  Lean adolescent girls with PCOS did not have more clinically significant depression than girls in the community. Within the PCOS cohort, however, there was a clear association between higher depression scores and elevated BMI. There is a potentially important interaction between obesity and depression in PCOS.
authors: Department of Endocrinology, Fertility Associates, Ascot Hospital, Auckland, New Zealand. s.milsom@auckland.ac.nz
authors: Stella R
authors: SR
authors: Milsom
authors: Sasha M
authors: SM
authors: Nair
authors: Cara M
authors: CM
authors: Ogilvie
authors: Joanna M
authors: JM
authors: Stewart
authors: Sally N
authors: SN
authors: Merry
mesh_terms: D000152:Acne Vulgaris / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D003863:Depression / Q000453:epidemiology*; D005260:Female; D006801:Humans; D009520:New Zealand / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology*; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D011795:Surveys and Questionnaires; D055815:Young Adult