title: T4216C mutation in NADH dehydrogenase I gene is associated with recurrent pregnancy loss.
abstract: Several genetic factors are involved with recurrent pregnancy loss (RPL). However, few attempts have been made to associate mitochondrial DNA (mtDNA) variations with RPL. Therefore, we investigated the possible effect of the T4216C mutation in the mitochondrial NADH dehydrogenase I (ND1) gene of 33 women with RPL and 100 controls, using polymerase chain reaction amplification and DNA sequence analysis. Our results showed a statistically significant association of the T4216C mutation (p <  0.05) between patients and controls, which are 30% and 11%, respectively. In conclusion, more research is essentially needed to understand the effect and role of the T4216C mutation in the progress of RPL, which may vary among individuals and different ethnic groups.
authors: Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran , Babolsar Postal Code 47416-95447 Mazandaran , Iran.
authors: Abasalt Hosseinzadeh
authors: AH
authors: Colagar
authors: Elaheh
authors: E
authors: Mosaieby
authors: Seyed Mohammad
authors: SM
authors: Seyedhassani
authors: Maryam
authors: M
authors: Mohajerani
authors: Ahoora
authors: A
authors: Arasteh
authors: Behnam
authors: B
authors: Kamalidehghan
authors: Massoud
authors: M
authors: Houshmand
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000235:genetics; D042967:Electron Transport Complex I / Q000235:genetics*; D020964:Embryo Loss / Q000235:genetics; D005260:Female; D006801:Humans; D007492:Iran; D020125:Mutation, Missense; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial; D042967:Electron Transport Complex I