title: Elevated plasma visfatin concentrations in patients with community-acquired pneumonia.
abstract: Visfatin has been associated with some inflammatory disease. This study aimed to compare plasma visfatin levels in patients with community-acquired pneumonia and healthy controls and to furthermore investigate the relationship between their concentrations and 30-day mortality in patients. Plasma visfatin concentrations were measured in 176 patients and 95 healthy controls. The admission visfatin levels were significantly increased in all patients, survivals and non-survivals with community-acquired pneumonia compared with healthy control individuals, associated with pneumonia severity index score, Acute Physiology and Chronic Health Evaluation II score, white blood cell count, and plasma C-reactive protein level, and identified as an independent predictor for 30-day mortality. Its predictive value was similar to those of pneumonia severity index score and Acute Physiology and Chronic Health Evaluation II score. However, visfatin did not statistically significantly improve the predictive values of pneumonia severity index score and Acute Physiology and Chronic Health Evaluation II score. Thus, higher plasma visfatin level correlates with disease severity and markers of system inflammation and represent a novel biomarker for predicting 30-day mortality in patients with community-acquired pneumonia.
authors: Department of Intensive Care Unit, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China. hzhuweihuwei@163.com
authors: Wei
authors: W
authors: Hu
authors: Chang-Wen
authors: CW
authors: Liu
authors: Jun
authors: J
authors: Su
authors: Jun
authors: J
authors: Lu
authors: Ying
authors: Y
authors: Zhu
authors: Bing-Wei
authors: BW
authors: Liu
mesh_terms: D000368:Aged; D017714:Community-Acquired Infections / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011014:Pneumonia / Q000097:blood* / Q000175:diagnosis
chemical_list: D054409:Nicotinamide Phosphoribosyltransferase