title: Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase.
abstract: Maribavir (MBV) inhibits Epstein-Barr virus (EBV) replication and the enzymatic activity of the viral protein kinase BGLF4. MBV also inhibits expression of multiple EBV transcripts during EBV lytic infection. Here we demonstrate, with the use of a BGLF4 knockout virus, that effects of MBV on transcription take place primarily through inhibition of BGLF4. MBV inhibits viral genome copy numbers and infectivity to levels similar to and exceeding levels produced by BGLF4 knockout virus.
authors: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors: Christopher B
authors: CB
authors: Whitehurst
authors: Marcia K
authors: MK
authors: Sanders
authors: Mankit
authors: M
authors: Law
authors: Fu-Zhang
authors: FZ
authors: Wang
authors: Jie
authors: J
authors: Xiong
authors: Dirk P
authors: DP
authors: Dittmer
authors: Joseph S
authors: JS
authors: Pagano
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002460:Cell Line; D015536:Down-Regulation / Q000187:drug effects*; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D015967:Gene Expression Regulation, Viral / Q000187:drug effects*; D016679:Genome, Viral / Q000187:drug effects; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000235:genetics* / Q000502:physiology; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D012263:Ribonucleosides / Q000494:pharmacology*; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects; D004004:Dichlororibofuranosylbenzimidazole / Q000031:analogs & derivatives
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles; D017346:Protein Serine-Threonine Kinases; D012263:Ribonucleosides; D014764:Viral Proteins; C406063:BGLF4 protein, Epstein-Barr virus; C400401:maribavir; D004004:Dichlororibofuranosylbenzimidazole