title: TransRadial Education and Therapeutics (TREAT): shifting the balance of safety and efficacy of antithrombotic agents in percutaneous coronary intervention: a report from the Cardiac Safety Research Consortium.
abstract: Percutaneous coronary intervention (PCI) is an integral part of the treatment of coronary artery disease. The most common complication of PCI, bleeding, typically occurs at the vascular access site and is associated with short-term and long-term morbidity and mortality. Periprocedural bleeding also represents the primary safety concern of concomitant antithrombotic therapies essential for PCI success. Use of radial access for PCI reduces procedural bleeding and hence may change the risk profile and net clinical benefit of these drugs. This new drug-device safety interaction creates opportunities to advance the safe and effective use of antithrombotic agents during PCI. In June 2010 and March 2011, leaders from government, academia, professional societies, device manufacturing, and pharmaceutical industries convened for 2 think tank meetings. Titled TREAT I and II, these forums examined approaches to improve the overall safety of PCI by optimizing strategies for antithrombotic drug use and radial artery access. This article summarizes the content and proceedings of these sessions.
authors: Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
authors: Connie N
authors: CN
authors: Hess
authors: Sunil V
authors: SV
authors: Rao
authors: David F
authors: DF
authors: Kong
authors: Julie M
authors: JM
authors: Miller
authors: Kevin J
authors: KJ
authors: Anstrom
authors: Olivier F
authors: OF
authors: Bertrand
authors: Jean-Philippe
authors: JP
authors: Collet
authors: Mark B
authors: MB
authors: Effron
authors: Benjamin C
authors: BC
authors: Eloff
authors: Emmanuel O
authors: EO
authors: Fadiran
authors: Andrew
authors: A
authors: Farb
authors: Ian C
authors: IC
authors: Gilchrist
authors: David R
authors: DR
authors: Holmes
authors: Alice K
authors: AK
authors: Jacobs
authors: Prashant
authors: P
authors: Kaul
authors: L Kristin
authors: LK
authors: Newby
authors: David R
authors: DR
authors: Rutledge
authors: Dale R
authors: DR
authors: Tavris
authors: Thomas T
authors: TT
authors: Tsai
authors: Roseann M
authors: RM
authors: White
authors: Eric D
authors: ED
authors: Peterson
authors: Mitchell W
authors: MW
authors: Krucoff
mesh_terms: D003324:Coronary Artery Disease / Q000601:surgery*; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods*; D019106:Postoperative Hemorrhage / Q000209:etiology*; D017534:Radial Artery / Q000601:surgery*
chemical_list: D005343:Fibrinolytic Agents