title: The frequency of osteoporosis in patients with pemphigus vulgaris on treatment.
abstract: BACKGROUND
  Pemphigus vulgaris was almost fatal before the advent of glucocorticoids. Unfortunately, the high doses and prolonged administration of glucocorticoids, which often needed to control the disease, result in numerous adverse effects many of which are serious.
  
  
  OBJECTIVE
  To evaluate the patients with pemphigus vulgaris on treatment in respect of osteoporosis and to compare the frequency of osteoporosis in these patients with the healthy ones.
  
  
  METHODS
  The study consisted of 40 patients with pemphigus vulgaris and 34 healthy controls. Bone mineral density measurements were obtained by dual- energy X-ray absorptiometry. Blood serum, bone parameters, and biochemical hormonal measurements were examined in both groups.
  
  
  RESULTS
  When the bone mineral density values of patients with pemphigus vulgaris were compared with those of the control group, there was no significant difference between hip bone mineral density values, while lumbar region T and Z scores were found significantly low in the patient group (p = 0.034 and p = 0.006, respectively). Osteoporosis, osteopenia, and normal dual-energy X-ray absorptiometry rates in the patient group were found to be 32.5%, 32.5%, and 35%, respectively. These rates were found to be 18%, 23%, and 59% in control group, respectively. There were more fractures in the patient group and the difference was statistically significant (p = 0.004).
  
  
  CONCLUSIONS
  An increase in osteoporosis frequency and secondary fracture to osteoporosis in the patients with pemphigus vulgaris was detected.
authors: Department of Dermatology, Dicle University, Diyarbakir, Turkey.
authors: Derya
authors: D
authors: Uçmak
authors: Mehmet
authors: M
authors: Harman
authors: Feyzullah
authors: F
authors: Uçmak
authors: Veysi
authors: V
authors: Akpolat
mesh_terms: D000328:Adult; D015519:Bone Density / Q000502:physiology; D005260:Female; D050723:Fractures, Bone / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D010392:Pemphigus / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome