title: [Association of polymorphisms of PTPN22 and PADI4 genes with rheumatoid arthritis in Yunnan].
abstract: OBJECTIVE
  To assess the association between genetic polymorphisms of 7 SNPs in PTPN22 and PADI4 genes and susceptibility to rheumatoid arthritis in Yunnan.
  
  
  METHODS
  A case-control study was carried out on 192 patients of rheumatoid arthritis and 288 healthy controls. Genotypes of rs33996649 and 1858 loci within PTPN22 gene, and rs11203366 and rs874881 loci within PADI4 gene were determined with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Genotypes of rs1635579, rs2428736 and rs2240340 in PADI4 gene were determined with pyrosequencing.
  
  
  RESULTS
  The frequencies of alleles and genotypes of rs2240340 locus in PADI4 gene showed a significant difference between rheumatoid arthritis and controls in Yunnan population (P U+003C 0.05).
  
  
  CONCLUSIONS
  Our results suggested that rs2240340 in PADI4 gene is associated with susceptibility to rheumatoid arthritis in Yunnan.
authors: Department of Medical Genetics, Chinese Academic of Medical Science, Kunming, Yunnan, People's Republic of China.
authors: Qian
authors: Q
authors: Li
authors: Ke-qin
authors: KQ
authors: Lin
authors: Qin
authors: Q
authors: Li
authors: Jing
authors: J
authors: Wang
authors: Juan
authors: J
authors: Yu
authors: Liang
authors: L
authors: Yu
authors: Wei
authors: W
authors: Yi
authors: Xiao-qin
authors: XQ
authors: Huang
authors: Jia-you
authors: JY
authors: Chu
authors: Zhao-qing
authors: ZQ
authors: Yang
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006867:Hydrolases / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases
chemical_list: D006867:Hydrolases; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; C000629235:PADI4 protein, human; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases