title: Possible significance of anti-heat shock protein (HSP-65) antibodies in autoimmune myasthenia gravis.
abstract: Myasthenia gravis (MG) is an autoimmune disorder caused by antibody-mediated attack against skeletal muscle nicotinic acetylcholine receptor (AchR) at neuromuscular junction. A close relationship exists between heat shock proteins (HSPs) and numerous autoimmune diseases. HSPs are over expressed to protect the host against various insults. Antibodies to HSP-65 (IgG, IgA, IgM) are evaluated in 40 MG sera by ELISA. About 80% of MG cases showed anti-HSP antibodies (62.5% IgG, 55% IgA, 40% IgM). The result suggests that, expression of HSP-65 increases in MG and most individuals produce antibodies to it. These antibodies might play a significant role in the pathogenesis of MG.
authors: Department of Neuro-Microbiology, National Institute of Mental Health and Neuro-Sciences, Hosur Road, Bangalore-560029, India. shripadpatil@yahoo.com
authors: S A
authors: SA
authors: Patil
authors: S
authors: S
authors: Katyayani
authors: A
authors: A
authors: Sood
authors: A K
authors: AK
authors: Kavitha
authors: P
authors: P
authors: Marimuthu
authors: A B
authors: AB
authors: Taly
mesh_terms: D001323:Autoantibodies / Q000096:biosynthesis*; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000276:immunology*; D018834:Chaperonin 60; D024101:Mitochondrial Proteins
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D006360:Heat-Shock Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C060293:HSPD1 protein, human; D018834:Chaperonin 60; D024101:Mitochondrial Proteins