title: Comparison of live Eimeria vaccination with in-feed salinomycin on growth and immune status in broiler chickens.
abstract: Coccidiosis vaccines and anticoccidial drugs are commonly used to control Eimeria infection during commercial poultry production. The present study was conducted to compare the relative effectiveness of these two disease control strategies in broiler chickens in an experimental research facility. Birds were orally vaccinated with a live, attenuated vaccine (Inovocox), or were provided with in-feed salinomycin (Bio-Cox), and body weights, serum levels of nitric oxide (NO) and antibodies against Eimeria profilin and Clostridium perfringens PFO proteins, and intestinal levels of cytokine gene transcripts were measured. Vaccinated chickens had increased body weights, greater NO levels, and higher profilin and PFO antibody levels compared with salinomycin-fed birds. Transcripts for interleukin-6 (IL-6), tumor necrosis factor superfamily 15, and interferon-γ were increased, while mRNAs for IL-4 and IL-10 were decreased, in immunized chickens compared with salinomycin-treated chickens. In conclusion, vaccination against avian coccidiosis may be more effective compared with dietary salinomycin for increasing body weight and augmenting pro-inflammatory immune status during commercial poultry production.
authors: Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, USDA, Beltsville, MD 20705, United States.
authors: Kyung-Woo
authors: KW
authors: Lee
authors: Hyun-Soon
authors: HS
authors: Lillehoj
authors: Seung-Ik
authors: SI
authors: Jang
authors: Sung-Hyen
authors: SH
authors: Lee
authors: Daniel A
authors: DA
authors: Bautista
authors: G
authors: G
authors: Donald Ritter
authors: Erik P
authors: EP
authors: Lillehoj
authors: Gregory R
authors: GR
authors: Siragusa
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D001835:Body Weight / Q000276:immunology; D002645:Chickens; D003048:Coccidiosis / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D004539:Eimeria / Q000276:immunology*; D009569:Nitric Oxide / Q000097:blood; D011201:Poultry Diseases / Q000276:immunology / Q000469:parasitology* / Q000517:prevention & control*; D016052:Protozoan Vaccines / Q000494:pharmacology*; D011714:Pyrans / Q000494:pharmacology*; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics; D011897:Random Allocation; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D000095662:Polyether Polyketides
chemical_list: D000913:Antibodies, Protozoan; D016207:Cytokines; D009569:Nitric Oxide; D016052:Protozoan Vaccines; D011714:Pyrans; D012333:RNA, Messenger; C010327:salinomycin; D000095662:Polyether Polyketides