title: An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: a 28-day repeated dose test and reproduction/developmental toxicity test.
abstract: A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N'-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28 days at 0, 100, 300, or 1000 mg/kg bw/day or for a total of 42-46 days at 0, 8, 50, or 300 mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicity study up to 1000 mg/kg bw/day in both sexes. In the reproduction/developmental toxicity study, two females showed piloerection, hypothermia, and pale skin; one died and the other showed dystocia on day 23 of pregnancy at 300 mg/kg bw/day. Another female delivered only three live pups at 300 mg/kg bw/day. A significantly prolonged gestation period was observed at 50 and 300 mg/kg bw/day. The NOAELs of repeated dose toxicity and reproduction/developmental toxicity were considered to be 1000 and 8 mg/kg bw/day, respectively.
authors: Division of Risk Assessment, Biological Safety Center, National Institute of Health Sciences, Tokyo 158-8501, Japan.
authors: Mariko
authors: M
authors: Matsumoto
authors: Makiko
authors: M
authors: Yamaguchi
authors: Yuka
authors: Y
authors: Yoshida
authors: Mika
authors: M
authors: Senuma
authors: Hiromasa
authors: H
authors: Takashima
authors: Tomoko
authors: T
authors: Kawamura
authors: Hina
authors: H
authors: Kato
authors: Mika
authors: M
authors: Takahashi
authors: Mutsuko
authors: M
authors: Hirata-Koizumi
authors: Atsushi
authors: A
authors: Ono
authors: Kazuhito
authors: K
authors: Yokoyama
authors: Akihiko
authors: A
authors: Hirose
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D036801:Parturition / Q000187:drug effects*; D010655:Phenylenediamines / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D010655:Phenylenediamines; C004845:N,N'-diphenyl-4-phenylenediamine