title: Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children.
abstract: BACKGROUND
  Bisphenol A (BPA) is used widely to manufacture food container linings. Mouse models suggest exposure to BPA might increase allergic inflammation.
  
  
  OBJECTIVE
  We hypothesized that BPA exposure, as assessed based on urinary BPA concentrations, would be associated with increased odds of wheeze and asthma and increased fraction of exhaled nitric oxide (Feno) values in children.
  
  
  METHODS
  The Columbia Center for Children's Environmental Health recruited pregnant women for a prospective birth cohort study (n = 568). Mothers during the third trimester and children at ages 3, 5, and 7 years provided spot urine samples. Total urinary BPA concentrations were measured by using online solid-phase extraction, high-performance liquid chromatography, isotope-dilution tandem mass spectrometry. Wheeze in the last 12 months was measured by using questionnaires at ages 5, 6, and 7 years. Asthma was determined by a physician once between ages 5 and 12 years. Feno values were measured at ages 7 to 11 years.
  
  
  RESULTS
  Prenatal urinary BPA concentrations were associated inversely with wheeze at age 5 years (odds ratio [OR], 0.7; 95% CI, 0.5-0.9; P = .02). Urinary BPA concentrations at age 3 years were associated positively with wheeze at ages 5 years (OR, 1.4; 95% CI, 1.1-1.8; P = .02) and 6 years (OR, 1.4; 95% CI, 1.0-1.9; P = .03). BPA concentrations at age 7 years were associated with wheeze at age 7 years (OR, 1.4; 95% CI, 1.0-1.9; P = .04) and Feno values (β = 0.1; 95% CI, 0.02-0.2; P = .02). BPA concentrations at ages 3, 5, and 7 years were associated with asthma (OR, 1.5 [95% CI, 1.1-2.0], P = .005; OR, 1.4 [95% CI, 1.0-1.9], P = .03; and OR, 1.5 [95% CI, 1.0-2.1], P = .04, respectively).
  
  
  CONCLUSIONS
  This is the first report of an association between postnatal urinary BPA concentrations and asthma in children.
authors: Division of Pulmonary, Allergy and Critical Care, Columbia University School of Physicians and Surgeons, New York, NY, USA. Kd2128@columbia.edu
authors: Kathleen M
authors: KM
authors: Donohue
authors: Rachel L
authors: RL
authors: Miller
authors: Matthew S
authors: MS
authors: Perzanowski
authors: Allan C
authors: AC
authors: Just
authors: Lori A
authors: LA
authors: Hoepner
authors: Srikesh
authors: S
authors: Arunajadai
authors: Stephen
authors: S
authors: Canfield
authors: David
authors: D
authors: Resnick
authors: Antonia M
authors: AM
authors: Calafat
authors: Frederica P
authors: FP
authors: Perera
authors: Robin M
authors: RM
authors: Whyatt
mesh_terms: D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000175:diagnosis* / Q000652:urine; D001559:Benzhydryl Compounds / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000652:urine*; D004968:Estrogens, Non-Steroidal / Q000652:urine*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000652:urine; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008431:Maternal-Fetal Exchange; D016017:Odds Ratio; D010636:Phenols / Q000652:urine*; D011247:Pregnancy; D012135:Respiratory Sounds / Q000175:diagnosis*; D000098826:Bisphenol A Compounds
chemical_list: D000485:Allergens; D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D004968:Estrogens, Non-Steroidal; D007073:Immunoglobulin E; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds