title: Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system.
abstract: Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.
authors: Institute of Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.
authors: Shlomit
authors: S
authors: Guy
authors: Dvir
authors: D
authors: Rotem
authors: Zvi
authors: Z
authors: Hayouka
authors: Ronen
authors: R
authors: Gabizon
authors: Aviad
authors: A
authors: Levin
authors: Limor
authors: L
authors: Zemel
authors: Abraham
authors: A
authors: Loyter
authors: Danny
authors: D
authors: Porath
authors: Assaf
authors: A
authors: Friedler
mesh_terms: D018076:DNA, Complementary / Q000235:genetics / Q000378:metabolism; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D004789:Enzyme Activation; D019427:HIV Integrase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016325:HIV Long Terminal Repeat / Q000235:genetics; D018625:Microscopy, Atomic Force
chemical_list: D018076:DNA, Complementary; D004279:DNA, Viral; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1