title: Endogenous sex hormones and their associations with cardiovascular risk factors in post-menopausal women.
abstract: OBJECTIVE
  Our aim was to understand the relationship between endogenous sex hormones and cardiovascular disease (CVD) risk factors in post-menopausal women.
  
  
  METHODS
  Eighty-three post-menopausal women from a previous prospectively designed study were included. We analyzed endogenous sex hormones and biochemical parameters.
  
  
  RESULTS
  Levels of estradiol and free testosterone were higher in patients with metabolic syndrome. Estradiol correlated positively with interleukin-6 (IL-6), weight, body mass index (BMI), insulin, homocysteine, and homeostasis model assessment of insulin resistance (HOMA-IR). Free testosterone correlated positively with weight, waist circumference (WC), BMI, insulin, HOMA-IR and negatively with HDL and SHBG. DHEAS correlated only with HDL. FSH correlated negatively with age, weight, WC, hip circumference, BMI, systolic blood pressure, diastolic blood pressure, duration of menopause, fasting glucose, HDL, C-reactive protein, and insulin. LH correlated negatively with IL-6, age, WC, duration of menopause and SHBG.
  
  
  CONCLUSIONS
  We identified endogenous estradiol and free testosterone as the strongest links to CVD risk. They can be used as biomarkers for CVD risk estimation.
authors: Department of Obstetrics and Gynecology, Istanbul Bilim University, Kisikli cad. No. 106, Altunizade, 34692, Istanbul, Turkey. nilgun.kutay@gmail.com.
authors: N
authors: N
authors: Güdücü
authors: U
authors: U
authors: Görmüş
authors: S S
authors: SS
authors: Kutay
authors: Z N
authors: ZN
authors: Kavak
authors: B
authors: B
authors: Telatar
mesh_terms: D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000209:etiology*; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D015850:Interleukin-6 / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood; D008875:Middle Aged; D008954:Models, Biological; D017698:Postmenopause / Q000097:blood*; D012189:Retrospective Studies; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood*; D055105:Waist Circumference
chemical_list: D012739:Gonadal Steroid Hormones; D007328:Insulin; D015850:Interleukin-6; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol