title: ALOX5 is associated with tuberculosis in a subset of the pediatric population of North China.
abstract: BACKGROUND
  Genetic factors are involved in the etiology of Mycobacterium tuberculosis infection. Recently, ALOX5 has been identified as a candidate gene for tuberculosis (TB) susceptibility. We investigated whether an association between ALOX5 and TB exists in a Chinese pediatric population from northern China.
  
  
  METHODS
  We conducted a case-control study comprising 488 individuals aged 2 months to 17 years by genotyping 18 tag-single-nucleotide polymorphisms (SNPs) from the ALOX5 gene. The tag-SNPs were selected from the international HapMap project. An Illumina BeadXpress Scanner was utilized for genotyping, supported by the high-density BeadArray technology in combination with an allele-specific extension, adapter ligation, and amplification assay. Statistical analyses were performed to determine correlations between genetic variation and disease.
  
  
  RESULTS
  Our study is the first to show that ALOX5 is associated with susceptibility to pediatric TB in a subset of children in northern China. The rs2115819 T allele of ALOX5 presents a risk factor for childhood TB disease.
authors: Beijing Pediatric Research Institute, Beijing Children's Hospital, affiliated with Capital Medical University, Beijing, China.
authors: Chen
authors: C
authors: Shen
authors: Xi-Rong
authors: XR
authors: Wu
authors: Bin-Bin
authors: BB
authors: Wang
authors: Lin
authors: L
authors: Sun
authors: Wei-Wei
authors: WW
authors: Jiao
authors: Jing
authors: J
authors: Wang
authors: Wei-Xing
authors: WX
authors: Feng
authors: Jing
authors: J
authors: Xiao
authors: Qing
authors: Q
authors: Miao
authors: Fang
authors: F
authors: Liu
authors: Qing-Qin
authors: QQ
authors: Yin
authors: Xu
authors: X
authors: Ma
authors: A-Dong
authors: AD
authors: Shen
mesh_terms: D000293:Adolescent; D001094:Arachidonate 5-Lipoxygenase / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007223:Infant; D008297:Male; D009169:Mycobacterium tuberculosis; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000382:microbiology
chemical_list: D001094:Arachidonate 5-Lipoxygenase; C583212:ALOX5 protein, human