title: The role of recombinant PTH in human fracture healing: a systematic review.
abstract: OBJECTIVE
  Human parathyroid hormone (PTH) is known to be efficacious in the treatment of osteoporosis and reduction of risk of vertebral and nonvertebral fractures; however, its role in the enhancement of human fracture healing is controversial. Our objective is to conduct a systematic literature review on the use of recombinant PTH in human fracture healing to (1) evaluate the evidence for recombinant PTH in human fracture healing and (2) assess whether there are notable differences between previous case reports and prospective trials.
  
  
  METHODS
  We performed a literature search in PubMed, EMBASE, Web of Science, and the Cochrane Database of Systematic Reviews for "teriparatide," "PTH (1-84)," "fracture," and "healing."
  
  
  METHODS
  References of retrieved articles were screened for additional studies, and exclusion criteria were applied.
  
  
  METHODS
  Due to the limited publications on the subject, case reports and case series were included in our data analysis.
  
  
  RESULTS
  Due to the limited publications on the subject, our data are presented in simple tabular format.
  
  
  CONCLUSIONS
  Our literature review yielded 16 publications on the use of recombinant PTH in human fracture healing and 2 randomized controlled trial with 1 retrospective subgroup analysis. There continues to be anecdotal evidence for the use of recombinant PTH to enhance fracture healing. There are discrepancies in study design in the randomized controlled trials and the majority of case reports and, additional prospective studies are warranted.
authors: *Harvard Medical School, Boston, MA; †Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA; ‡Hospital for Special Surgery, New York, NY; and §Weill Cornell Medical College, New York, NY.
authors: Dafang
authors: D
authors: Zhang
authors: Anish
authors: A
authors: Potty
authors: Parth
authors: P
authors: Vyas
authors: Joseph
authors: J
authors: Lane
mesh_terms: D017102:Fracture Healing / Q000187:drug effects*; D050723:Fractures, Bone / Q000188:drug therapy*; D006801:Humans; D010281:Parathyroid Hormone / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology*
chemical_list: C470125:PTH protein, human; D010281:Parathyroid Hormone; D011994:Recombinant Proteins