title: Pediatric gliosarcoma with fibrosarcomatous differentiation: report of a rare case.
abstract: Gliosarcoma is a rare variant of glioblastoma with a biphasic pattern showing glial and mesenchymal differentiation. It is seen in adults during their fifth to sixth decades of life and is extremely rare in children. We report a case of primary gliosarcoma with fibrosarcomatous differentiation in an 11-year-old boy presenting with headache and vomiting. Imaging showed a contrast-enhancing isodense space-occupying lesion with areas of calcification in the right temporoparietal cortex. A total excision was done and, on histopathologic examination, a differential diagnostic consideration of gliosarcoma and teratoma with malignant transformation was made. After immunohistochemical analysis, a final diagnosis of gliosarcoma with fibrosarcomatous differentiation was then made. Primary gliosarcoma is a very rare tumor in children with a poor prognosis.
authors: Department of Pathology, Institute of Neurology, Madras Medical College, Chennai, India.
authors: Shantha
authors: S
authors: Ravisankar
authors: R Vimal
authors: RV
authors: Chander
authors: Prem Kumar
authors: PK
authors: Devadoss
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001921:Brain / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D002648:Child; D005354:Fibrosarcoma / Q000175:diagnosis* / Q000473:pathology*; D018316:Gliosarcoma / Q000175:diagnosis* / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008853:Microscopy; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor