title: USA300 methicillin-resistant Staphylococcus aureus emerging as a cause of bloodstream infections at military medical centers.
abstract: BACKGROUND
  USA300 methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of skin and soft-tissue infection (SSTI) in military personnel. USA300 MRSA has emerged as an important cause of healthcare-associated bloodstream infection (BSI) in metropolitan centers.
  
  
  OBJECTIVE
  To determine the prevalence, risk factors, and patient outcomes associated with USA300 MRSA BSI in military tertiary medical centers.
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  Patients admitted during the period 2001-2009 with MRSA BSI.
  
  
  METHODS
  Walter Reed Army Medical Center (Washington, DC) and National Naval Medical Center (Bethesda, MD) tertiary medical centers with 500 inpatient beds combined, which provide care to active duty service members and military beneficiaries.
  
  
  METHODS
  After identifying patients with MRSA BSI, we collected epidemiological data from electronic medical records and characterized bacterial isolates using pulsed-field gel electrophoresis (PFGE).
  
  
  RESULTS
  A total of 245 MRSA BSI cases were identified, and 151 isolates were available for analysis. Epidemiological characteristics for the 151 patients with available isolates included the following: mean age, 61 years; male sex, 70%; white race, 62%; and combat-wounded service members, 11%. The crude in-hospital mortality rate was 17%. PFGE demonstrated that 30 (20%) of 151 MRSA BSI cases with isolates available for analysis were due to USA300, and 27 (87%) of these 30 cases were healthcare-associated infection. USA300 was associated with a significantly increasing proportion of MRSA BSI when examined over sequential time periods: 2 (4%) of 51 isolates during 2001-2003, 9 (19%) of 47 isolates during 2004-2006, and 19 (36%) of 53 isolates during 2007-2009 ([Formula: see text]).
  
  
  CONCLUSIONS
  USA300 MRSA is emerging as a cause of healthcare-associated BSI in tertiary military medical centers.
authors: Department of Medicine, William Beaumont Army Medical Center, El Paso, TX 79920, USA. jeffrey.e.sherwood@us.army.mil
authors: Jeffrey
authors: J
authors: Sherwood
authors: Matthew
authors: M
authors: Park
authors: Paul
authors: P
authors: Robben
authors: Timothy
authors: T
authors: Whitman
authors: Michael W
authors: MW
authors: Ellis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology / Q000401:mortality; D015373:Bacterial Typing Techniques; D016022:Case-Control Studies; D003428:Cross Infection / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology / Q000401:mortality; D004219:District of Columbia / Q000453:epidemiology; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D017052:Hospital Mortality; D006772:Hospitals, Military; D006801:Humans; D016015:Logistic Models; D008297:Male; D008396:Maryland / Q000453:epidemiology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification* / Q000302:isolation & purification; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology / Q000401:mortality; D014481:United States