title: Dietary restriction in C. elegans: recent advances.
abstract: The nematode Caenorhabditis elegans continues to serve as a useful model of life extension caused by dietary restriction. Using this model, downstream effectors of dietary restriction-induced longevity have been elucidated, including neuropeptides and cell-surface receptors. Although it remains possible that different forms of dietary restriction may utilize both specific and overlapping mechanisms to promote longevity, the nematode model has revealed roles for autophagy, metabolic energy-sensing and the hypoxic response. The nematode has also been used to identify specific tissues required for life extension via DR, including coelomocytes, intestine, and neurons.
authors: Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.
authors: James R
authors: JR
authors: Cypser
authors: David
authors: D
authors: Kitzenberg
authors: Sang-Kyu
authors: SK
authors: Park
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D031204:Caloric Restriction; D004268:DNA-Binding Proteins / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D008136:Longevity / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology; D009928:Organ Specificity / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological / Q000502:physiology; D058570:TOR Serine-Threonine Kinases / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
chemical_list: D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; D009479:Neuropeptides; D014157:Transcription Factors; C073702:skn-1 protein, C elegans; D058570:TOR Serine-Threonine Kinases
keywords: C. elegans; Coelomocyte; Dietary restriction; Neuropeptide; TOR pathway