title: Rotary blood pumps as definitive treatment for severe heart failure.
abstract: Rotary blood pumps are increasingly recognized as mainstream therapy for severely symptomatic heart failure. Carefully targeted refinements in patient selection and postoperative care have substantially reduced the adverse event burden. These improvements translate into better survival and quality of life in comparison with medical management. Medium-term outcomes now compete favorably with cardiac transplantation, although evidence-based outcome data indicate that transplant and 'lifetime' left ventricular-assist device (LVAD) candidates are fundamentally different. Significant challenges remain in relation to neurological injury and right heart failure, which may continue to limit exercise capacity. In the meantime, both physician awareness and patient access to LVAD technology remain limited. The debate is rarely between cardiac transplant or lifetime LVAD. It should focus on the choice between pump versus palliative care for the thousands of patients of all age groups who are judged ineligible for transplantation. Comprehensive healthcare systems must consider contemporary evidence and provide the most symptomatic of heart failure patients with effective care. Cardiac resynchronization therapy is no longer the ceiling for this.
authors: Oxford University Hospitals Trust, John Radcliffe Hospital, Department of Cardiac Surgery, Oxford, OX3 9DU, UK. swestaby@ahf.org.uk
authors: Stephen
authors: S
authors: Westaby
mesh_terms: D058406:Cardiac Resynchronization Therapy; D017079:Exercise Tolerance; D006333:Heart Failure / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D006353:Heart-Assist Devices; D006801:Humans; D010166:Palliative Care; D011379:Prognosis; D011474:Prosthesis Design; D012042:Registries; D016896:Treatment Outcome