title: Risk of genome-wide association study-identified genetic variants for non-Hodgkin lymphoma in a Chinese population.
abstract: Recent genome-wide association studies have identified 15 single nucleotide polymorphisms (SNPs) associated with non-Hodgkin lymphoma (NHL) and its subtypes. Because the incidence and subtype portion of NHL between the Chinese population and Caucasian populations are substantially different, we assessed the associations of these SNPs with NHL risk in a case-control study consisting of 792 cases and 1542 controls derived from the Chinese population. Odds ratios (OR) and 95% confidence intervals (CI) were computed by logistic regression. False-positive report probability was also assessed for significant findings. We found that the allele frequencies of the 15 SNPs in our study population significantly differed from those in Caucasian populations, with rs13397985, rs735665 and rs11083846 being extremely rare in Chinese. Only two variants (rs872071 in IRF4 and rs2647012 in HLA class II) were significantly associated with NHL risk in Chinese, with the ORs of 1.20 (95% CI, 1.05-1.38; P = 0.009) and 1.20 (95% CI, 1.03-1.39; P = 0.018) for per allele of rs872071 and rs2647012, respectively, calculated using an additive model. These results indicate a substantial different genetic background for susceptibility to NHL among the different ethnic populations.
authors: State Key Laboratory of Molecular Oncology and Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Yan
authors: Y
authors: Qiao
authors: Yuling
authors: Y
authors: Zhou
authors: Chen
authors: C
authors: Wu
authors: Kan
authors: K
authors: Zhai
authors: Xiaohong
authors: X
authors: Han
authors: Jieping
authors: J
authors: Chen
authors: Xiaobo
authors: X
authors: Tian
authors: Jiang
authors: J
authors: Chang
authors: Zheng
authors: Z
authors: Lu
authors: Bo
authors: B
authors: Zhang
authors: Dianke
authors: D
authors: Yu
authors: Jiarui
authors: J
authors: Yao
authors: Yuankai
authors: Y
authors: Shi
authors: Wen
authors: W
authors: Tan
authors: Dongxin
authors: D
authors: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D016001:Confidence Intervals; D005189:False Positive Reactions; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics; D055815:Young Adult