title: Favorable outcome of neonatal cerebrospinal fluid shunt-associated Candida meningitis with caspofungin.
abstract: Invasive Candida infections associated with medical devices are very difficult to cure without device removal. We present a case of neonatal cerebrospinal fluid shunt-associated Candida meningitis, in which removal of the device was precluded, that was successfully treated with caspofungin. Pharmacokinetic assessment of caspofungin concentrations in cerebrospinal fluid showed that exposure was adequate in the presence of a high systemic exposure. In complex cases of neonatal Candida infections involving medical devices, the addition of caspofungin might be beneficial.
authors: Department of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, Netherlands.
authors: Jop
authors: J
authors: Jans
authors: Roger J M
authors: RJ
authors: Brüggemann
authors: V
authors: V
authors: Christmann
authors: Paul E
authors: PE
authors: Verweij
authors: Adilia
authors: A
authors: Warris
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D000077336:Caspofungin; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects*; D054714:Echinocandins / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D055666:Lipopeptides; D008297:Male; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin