title: Neutron scattering: a tool to detect in vivo thermal stress effects at the molecular dynamics level in micro-organisms.
abstract: In vivo molecular dynamics in Halobacterium salinarum cells under stress conditions was measured by neutron scattering experiments coupled with microbiological characterization. Molecular dynamics alterations were detected with respect to unstressed cells, reflecting a softening of protein structures consistent with denaturation. The experiments indicated that the neutron scattering method provides a promising tool to study molecular dynamics modifications in the proteome of living cells induced by factors altering protein folds.
authors: Institut de Biologie Structurale, Grenoble, France.
authors: Vincent
authors: V
authors: Marty
authors: Marion
authors: M
authors: Jasnin
authors: Elisa
authors: E
authors: Fabiani
authors: Pierre
authors: P
authors: Vauclare
authors: Frank
authors: F
authors: Gabel
authors: Marcus
authors: M
authors: Trapp
authors: Judith
authors: J
authors: Peters
authors: Giuseppe
authors: G
authors: Zaccai
authors: Bruno
authors: B
authors: Franzetti
mesh_terms: D019843:Archaeal Proteins / Q000378:metabolism*; D019617:Halobacterium salinarum / Q000166:cytology / Q000378:metabolism*; D018869:Heat-Shock Response / Q000502:physiology*; D009502:Neutrons; D011489:Protein Denaturation; D020543:Proteome / Q000378:metabolism*; D012542:Scattering, Radiation
chemical_list: D019843:Archaeal Proteins; D020543:Proteome