title: Autologous stem cell transplantation in adults with metastatic sarcoma of the Ewing family: a single centre experience.
abstract: BACKGROUND
  Adults with metastatic Ewing family sarcomas (ES) after being treated with standard therapy for localised disease have limited treatment options with curative intent. The aim of this retrospective single centre study was to evaluate the efficacy of autologous stem cell transplantation (ASCT) in this patient population.
  
  
  METHODS
  We report on seven consecutive patients with ES. Four patients with initial localised disease developed distant metastases after being treated with initial standard pre-operative chemotherapy followed by surgery and subsequent standard post-operative chemotherapy. Three patients with initial metastatic disease were pre-treated with standard polychemotherapy. All patients received high-dose chemotherapy (HDCT) followed by ASCT for metastatic disease.
  
  
  RESULTS
  For patients with initial metastatic disease, partial remission (PR) was achieved in three patients prior to HDCT. Type of response subsequent to ASCT was complete response (CR) in four patients with initial localised disease and CR in two patients with initial metastatic disease. No patient died within the first 100 days after HDCT. Side effects were rare and manageable.
  
  
  CONCLUSIONS
  This retrospective analysis suggests that ASCT may be considered in patients with metastatic ES, previously treated with standard therapy.
authors: Sarcoma Program, Clinical Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
authors: Wolfgang
authors: W
authors: Lamm
authors: Werner
authors: W
authors: Rabitsch
authors: Wolfgang J
authors: WJ
authors: Köstler
authors: Peter
authors: P
authors: Kalhs
authors: Philipp
authors: P
authors: Ubl
authors: Thomas
authors: T
authors: Brodowicz
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy*; D017809:Fatal Outcome; D006801:Humans; D008875:Middle Aged; D012512:Sarcoma, Ewing / Q000556:secondary* / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents