title: Asymmetric synthesis of 1-heteroaryl-1-arylalkyl tertiary alcohols and 1-pyridyl-1-arylethanes by lithiation-borylation methodology.
abstract: The synthesis of highly enantioenriched α-heterocyclic tertiary alcohols has been achieved via lithiation-borylation of a configurationally stable lithiated carbamate and heterocyclic pinacol boronic esters followed by oxidation. Protodeboronation of the α-heterocyclic tertiary boronic esters using TBAF·3H2O or CsF gave highly enantioenriched 1-pyridyl-1-arylethanes in high er.
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
authors: Charlotte G
authors: CG
authors: Watson
authors: Varinder K
authors: VK
authors: Aggarwal