title: Novel function of Trim44 promotes an antiviral response by stabilizing VISA.
abstract: Virus-induced signaling adaptor (VISA) functions as a critical adaptor in the regulation of both the production of type I IFNs and the subsequent control of the innate antiviral response. In this study, we demonstrate that tripartite motif (Trim)44 interacts with VISA and promotes VISA-mediated antiviral responses. The overexpression of Trim44 enhances the cellular response to viral infection, whereas Trim44 knockdown yields the opposite effect. Trim44 stabilizes VISA by preventing VISA ubiquitination and degradation. These findings suggest that Trim44 functions as a positive regulator of the virus-triggered immune response by enhancing the stability of VISA.
authors: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors: Bo
authors: B
authors: Yang
authors: Jie
authors: J
authors: Wang
authors: Yanming
authors: Y
authors: Wang
authors: Haiyan
authors: H
authors: Zhou
authors: Xiaodong
authors: X
authors: Wu
authors: Zhigang
authors: Z
authors: Tian
authors: Bing
authors: B
authors: Sun
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D055785:Gene Knockdown Techniques; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B / Q000378:metabolism; D011485:Protein Binding; D055550:Protein Stability; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D015398:Signal Transduction; D000070584:Tripartite Motif Proteins; D054875:Ubiquitination; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology*; D014780:Viruses / Q000276:immunology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D007370:Interferon Type I; D047908:Intracellular Signaling Peptides and Proteins; C505371:MAVS protein, human; D016328:NF-kappa B; C437968:PLAAT4 protein, human; D018168:Receptors, Retinoic Acid; C540677:TRIM44 protein, human; D000070584:Tripartite Motif Proteins