title: Production of BSA-poly(ethyl cyanoacrylate) nanoparticles as a coating material that improves wetting property.
abstract: Alkyl cyanoacrylates have long been used for the synthesis of colloidal nanoparticles. In the involved polymerization reaction, hydroxyl ions derived from dissociation of water have been used as an initiator. In the current research, an animal protein, bovine serum albumin (BSA) molecules were utilized as initiator for the polymerization. Following this reaction scheme, hydrophobic poly(ethyl cyanoacrylate)s were covalently bound to BSA, which is hydrophilic. Therefore, the resultant copolymer was amphiphilic in nature, and formed nanoparticles in the reaction medium. The suspension containing these nanoparticles showed an excellent coating capability on the surface of hydrophobic materials. A simple spray coating changed the wetting property of the material instantly and dramatically.
authors: National Center for Agricultural Utilization Research, Agricultural Research Service, USDA, Peoria, IL 61604, USA. sanghoon.kim@ars.usda.gov
authors: S
authors: S
authors: Kim
authors: K
authors: K
authors: Evans
authors: A
authors: A
authors: Biswas
mesh_terms: D000327:Adsorption; D000818:Animals; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000494:pharmacology*; D003487:Cyanoacrylates / Q000138:chemical synthesis* / Q000494:pharmacology*; D057446:Hydrodynamics; D018625:Microscopy, Atomic Force; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D058525:Quartz Crystal Microbalance Techniques; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D017155:Wettability / Q000187:drug effects
chemical_list: D020099:Coated Materials, Biocompatible; D003487:Cyanoacrylates; C558475:poly(ethylcyanoacrylate); D012710:Serum Albumin, Bovine