title: [Expression of glypican-3 in lung squamous cell carcinoma and adenocarcinoma and its relation with prognosis].
abstract: OBJECTIVE
  To study the different expressions of glypican-3 in lung squamous cell carcinoma and adenocarcinoma and explore the association of glypican-3 with the prognosis of the patients.
  
  
  METHODS
  Glypican-3 expression was detected immunohistochemically in the tumor tissues and adjacent tissues from 48 cases of lung squamous cell carcinoma and adenocarcinoma. Kaplan-Meier method and log-rank test were used for survival analysis of the patients.
  
  
  RESULTS
  Glypican-3 expression was detected in the tumor tissues in 29.2% (14/48) of the cases, but not in the adjacent tissues. Of the 22 patients with lung squamous cell carcinoma, 12 (54.5%) showed positive glypican-3 expression in the tumor tissue, a rate significantly higher than that in patients with lung adenocarcinoma [7.7% (2/26), P<0.01]. In all the glypican-3-positive cases, the tumor tissues showed stronger glypican-3 expression in cases with lymph node metastasis or poor tumor differentiation. Kaplan-Meier survival analysis did not indicate a significant correlation of glypican-3 expression with the prognosis of the lung cancer patients.
  
  
  CONCLUSIONS
  Patients with lung squamous cell carcinoma have higher glypican-3 expressions in the tumor tissues than those with lung adenocarcinoma, suggesting the value of glypican-3 protein as a potential marker to detect lung squamous cell carcinoma.
authors: Department of Thoracic and Cardiovascular Surgery, Guangzhou Institute of Respiratory Disease, Guangzhou, China. lihuiling1975@126.com
authors: Huiling
authors: H
authors: Li
authors: Qiuhua
authors: Q
authors: Deng
authors: Liyan
authors: L
authors: Huang
authors: Hailing
authors: H
authors: Tang
authors: Xiangyang
authors: X
authors: Cheng
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D053673:Glypicans / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D016612:Paraffin Embedding; D011379:Prognosis
chemical_list: C105937:GPC3 protein, human; D053673:Glypicans