title: Childhood weight gain and thyroid autoimmunity at age 60-64 years: the 1946 British birth cohort study.
abstract: BACKGROUND
  Complex bidirectional relationships have been described between body weight, thyroid function, and risk of thyroid disorders, including thyroid autoimmunity. We used a life-course approach to examine the potential association of childhood or adult body weight with the risk of thyroid autoimmunity and other thyroid disorders at age 60-64 years in a large population-based birth cohort study.
  
  
  METHODS
  In the UK Medical Research Council 1946 British Birth Cohort study, at age 60-64 years, 1277 women and 1185 men (78% of the target sample) responded to a postal questionnaire, which included questions on thyroid disease and thyroid medication. Circulating antithyroid peroxidase antibodies, free T4, and TSH concentrations were measured in 1057 women and 997 men at a subsequent clinic visit. Birth weight was recorded, and height and weight were measured at ages 2, 4, 6, 7, 11, 15 years and also repeatedly in adulthood.
  
  
  RESULTS
  At age 60-64 years, 10.9% of women (139 of 1277) and 2.3% of men (27 of 1185) reported they were taking T4, and 11.5% of women (122 of 1057) and 3.3% of men (33 of 997) had positive anti-TPO antibodies (>100 IU/mL), consistent with thyroid autoimmunity. Among women, both T4 use and positive anti-TPO antibodies at age 60-64 years were positively associated with childhood body weight, childhood overweight, and adult body mass index. Childhood weight gain between 0 and 14 years of age was positively associated with later T4 use (odds ratio 1.21, 95% confidence interval 1.03-1.42) and positive anti-TPO antibodies (1.21, 1.00-1.47). Women who were overweight or obese at age 14 years (127 of 972) had a higher risk of later positive anti-TPO antibodies (2.05, 1.12-3.76). In men and women without any thyroid disorders, serum free T4 concentrations were inversely associated with concurrent body mass index (P = .002).
  
  
  CONCLUSIONS
  Childhood weight gain and childhood overweight conferred an increased susceptibility to later hypothyroidism and thyroid autoimmunity, particularly in women.
authors: Medical Research Council Unit for Lifelong Health and Ageing, London, United Kingdom. ken.ong@mrc-epid.cam.ac.uk
authors: Ken K
authors: KK
authors: Ong
authors: Diana
authors: D
authors: Kuh
authors: Mary
authors: M
authors: Pierce
authors: Jayne A
authors: JA
authors: Franklyn
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D015551:Autoimmunity / Q000502:physiology; D001724:Birth Weight / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D013959:Thyroid Diseases / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology / Q000209:etiology*; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology; D015430:Weight Gain / Q000502:physiology*; D055815:Young Adult