title: Is non-alcoholic steatohepatitis a predisposing factor to porphyria cutanea tarda?
abstract: Porphyria cutanea tarda (PCT) is a disease caused by a deficiency of the fifth enzyme of the heme biosynthetic pathway in the liver that manifests in the skin as blistering and fragility of predominantly sun-exposed skin. It occurs in individuals with environmental and/or genetic risk factors such as estrogen use, hepatitis C infection and hemochromatosis gene mutations. This report highlights a case of PCT which manifested in an individual with non-alcoholic fatty liver disease (non-alcoholic steatohepatitis; NASH). We propose that NASH may have been a contributing factor for the development of PCT in our patient.
authors: Vanderbilt University Medical Center, Nashville, TN, USA.
authors: Elizabeth N
authors: EN
authors: Ergen
authors: Elizabeth
authors: E
authors: Seidler
authors: Samir
authors: S
authors: Parekh
authors: Sareeta R S
authors: SR
authors: Parker
mesh_terms: D000328:Adult; D004781:Environmental Exposure / Q000009:adverse effects / Q000517:prevention & control*; D005234:Fatty Liver / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease; D017119:Porphyria Cutanea Tarda / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D012307:Risk Factors; D013472:Sunlight / Q000009:adverse effects; D015431:Weight Loss