title: Regular paracetamol in severe dengue: a lethal combination?
abstract: An eight-month-old female infant with severe dengue disease, who was repeatedly given therapeutic paracetamol for severe dengue, developed fulminant liver failure with encephalopathy, gastrointestinal haemorrhage and severe coagulopathy. She responded to supportive measures and N-acetylcysteine infusion. This case highlights the potential danger of administering repeated therapeutic doses of paracetamol in childhood severe dengue disease with hepatitis.
authors: Department of Paediatrics, University Malaya Medical Centre, Kuala Lumpur 59100, Malaysia.
authors: Chin Seng
authors: CS
authors: Gan
authors: Sze Yee
authors: SY
authors: Chong
authors: Lucy Chai See
authors: LC
authors: Lum
authors: Way Seah
authors: WS
authors: Lee
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects* / Q000627:therapeutic use; D058633:Antipyretics / Q000009:adverse effects* / Q000627:therapeutic use; D001777:Blood Coagulation; D005260:Female; D006501:Hepatic Encephalopathy / Q000188:drug therapy; D006801:Humans; D007223:Infant; D017114:Liver Failure, Acute / Q000139:chemically induced*; D019595:Severe Dengue / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D058633:Antipyretics; D000082:Acetaminophen