title: Premorbid impairments in early-onset psychosis: differences between patients with schizophrenia and bipolar disorder.
abstract: BACKGROUND
  Despite the large body of research on premorbid impairments in schizophrenia, studies comparing different early-onset psychoses are scarce.
  
  
  OBJECTIVE
  To examine premorbid impairments in first episodes of early-onset bipolar and schizophrenia disorders.
  
  
  METHODS
  We compared premorbid adjustment and other premorbid variables such as IQ and developmental abnormalities in a cohort of children and adolescents (N=69) with bipolar disorder (BP) or schizophrenia (SZ) experiencing their first psychotic episode and in a healthy control group (N=91).
  
  
  RESULTS
  Schizophrenia patients showed more social impairment in childhood than bipolar patients (p<0.05) and healthy controls (p<0.001) and had higher rates of developmental abnormalities (p<0.05) than healthy controls. Between childhood and early adolescence, schizophrenia and bipolar patients showed a greater decline in academic adjustment than healthy controls, more specifically in adaptation to school (p<0.01).
  
  
  CONCLUSIONS
  Early-onset schizophrenia patients show more early social impairment than early-onset bipolar patients. Intellectual premorbid abnormalities are less specific and probably more linked to early-onset psychosis.
authors: Child and Adolescent Psychiatry and Psychology Unit, Hospital Universitario Marques de Valdecilla, Santander, Spain. bpaya@humv.es
authors: Beatriz
authors: B
authors: Payá
authors: Jose Manuel
authors: JM
authors: Rodríguez-Sánchez
authors: Soraya
authors: S
authors: Otero
authors: Pedro
authors: P
authors: Muñoz
authors: Josefina
authors: J
authors: Castro-Fornieles
authors: Mara
authors: M
authors: Parellada
authors: Ana
authors: A
authors: Gonzalez-Pinto
authors: Cesar
authors: C
authors: Soutullo
authors: Inmaculada
authors: I
authors: Baeza
authors: Marta
authors: M
authors: Rapado-Castro
authors: Margarita
authors: M
authors: Sáenz-Herrero
authors: Dolores
authors: D
authors: Moreno
authors: Celso
authors: C
authors: Arango
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000150:complications / Q000175:diagnosis*; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications / Q000175:diagnosis*; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012737:Sex Factors; D012920:Social Behavior Disorders / Q000209:etiology*; D013030:Spain