title: Treatment of infrabony periodontal defects using a resorbable biopolymer of hyaluronic acid: a randomized clinical trial.
abstract: OBJECTIVE
  This randomized clinical study examined the use of hyaluronic acid to treat infrabony periodontal defects over a period of 24 months.
  
  
  METHODS
  Forty subjects with a two-wall infrabony defect (probing depth [PD] >= 7 mm; clinical attachment level [CAL] >= 7 mm) were selected. The defects were randomly divided into two groups: sites treated with hyaluronic acid (test group) and those treated with open flap debridement (control group).
  
  
  RESULTS
  The 12- and 24-month evaluations were based on clinical and radiographic parameters. The primary outcome variable was CAL. Test defects shows a mean CAL gain of 1.9 ± 1.8 mm, while the control defects yielded a significantly lower gain of 1.1 ± 0.7 mm. PD reduction was also significantly higher in the test group (1.6 ± 1.2 mm) than in the control group (0.8 ± 0.5 mm). Frequency distribution analysis of the study outcomes indicated that hyaluronic acid increased the predictability of clinically significant results (CAL gains >= 2 mm and PD reduction >= 2 mm) in the test group compared with the controls.
  
  
  CONCLUSIONS
  The treatment of infrabony defects with hyaluronic acid offered an additional benefit in terms of CAL gain, PD reduction, and predictability compared to treatment with open flap debridement.
authors: Department of Experimental Science Medicine and Stomatology, School of Dentistry, University of Messina, Messina, Italy.
authors: Francesco
authors: F
authors: Briguglio
authors: Enrico
authors: E
authors: Briguglio
authors: Roberto
authors: R
authors: Briguglio
authors: Carlo
authors: C
authors: Cafiero
authors: Gaetano
authors: G
authors: Isola
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000188:drug therapy* / Q000601:surgery*; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D057747:Periodontal Debridement; D055675:Viscosupplements / Q000627:therapeutic use*
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid