title: Dietary nucleotides extend the life span in Sprague-Dawley rats.
abstract: OBJECTIVE
  To observe the effect of prolonged feeding of dietary nucleotides (NTs), and to clarify the effect of NTs on life extension of Sprague-Dawley rats.
  
  
  METHODS
  There were 50 Sprague-Dawley rats in each group (male:female ratio=1:1), which were fed diets supplemented with NTs at concentrations of 0%, 0.01%, 0.04%, 0.16% and 0.64% (wt/wt) from the age of 4 weeks until natural death. We investigated the moribundity and mortality, survival time, spontaneous tumor incidence, and serum oxidative status.
  
  
  RESULTS
  NTs have signiﬁcantly inﬂuence body weight of first 3 month old and food consumption of male rats throughout the life span; it did dose-dependently inhibit the age-related decrease in the activities of antioxidant enzymes and the age-related increase in the levels of lipid peroxidation product in both sexes. NTs notably increased the mean life span, and the maximal life span. Compared to the control group, the incidence of death from tumors was decreased in NTs groups of both sexes.
  
  
  CONCLUSIONS
  Long-term feeding of NTs could dose-dependently increase life span in Sprague-Dawley rats, especially, the tumor-bearing ones. Moreover, the antioxidative property of NTs may be responsible for the increased life span.
authors: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China.
authors: M
authors: M
authors: Xu
authors: R
authors: R
authors: Liang
authors: Q
authors: Q
authors: Guo
authors: S
authors: S
authors: Wang
authors: M
authors: M
authors: Zhao
authors: Z
authors: Z
authors: Zhang
authors: J
authors: J
authors: Wang
authors: Y
authors: Y
authors: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D008017:Life Expectancy; D015227:Lipid Peroxidation / Q000187:drug effects; D008136:Longevity; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D009711:Nucleotides / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D009711:Nucleotides