title: [The pharmacokinetics of long-circulating beta-elemene liposomes].
abstract: OBJECTIVE
  To study the pharmacokinetics of long-circulating beta-elemene liposomes.
  
  
  METHODS
  Gas chromatography was established to determine the concentration of beta-elemene in plasma of rats.
  
  
  RESULTS
  The alpha, T(1/2beta), K12 and AUC of long-circulating beta-elemene liposomes groups were higher compared with those of the conventional liposomes,and the T(1/2alpha), Vc, CL, K10 of the latter were lower.
  
  
  CONCLUSIONS
  Long-circulating beta-elemene liposomes can prolong the duration of beta-elemene in the body and improve the efficacy of drugs.
authors: Hospital of Wuhan University of Technology, Wuhan 430070, China.
authors: Bing-jiang
authors: BJ
authors: Zhang
authors: Wei-chao
authors: WC
authors: Li
authors: Xiao-ping
authors: XP
authors: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002626:Chemistry, Pharmaceutical; D002849:Chromatography, Gas; D005260:Female; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008081:Liposomes; D008297:Male; D051379:Mice; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000493:pharmacokinetics; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000493:pharmacokinetics; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D010713:Phosphatidylcholines; D012717:Sesquiterpenes; C445979:beta-elemene; D011092:Polyethylene Glycols