title: Salivary morbidity and quality of life following radioactive iodine for well-differentiated thyroid cancer.
abstract: OBJECTIVE
  Determine the prevalence of sialadenitis in a group of patients treated with radioactive iodine (RAI) for well-differentiated thyroid cancer and assess whether RAI treatment is associated with a reduction in swallowing-related or global head and neck quality of life.
  
  
  METHODS
  Retrospective self-administered questionnaire study.
  
  
  METHODS
  Academic, tertiary care, National Cancer Institute-designated cancer center.
  
  
  METHODS
  Surviving patients seen for well-differentiated thyroid cancer were identified by review of the cancer center registry. Patients were mailed a baseline questionnaire, the M. D. Anderson Dysphagia Inventory (MDADI), the University of Washington Quality of Life Questionnaire (UW-QOL), and the Xerostomia-Related Quality of Life Scale (XeQOLS).
  
  
  RESULTS
  The study included 121 women and 24 men, with a mean age of 52 years. Radioactive iodine exposure was correlated with an increase in sialadenitis and was dose dependent (R (2) = 0.335, P < .001). Sialadenitis was 2.47 times more likely to occur in patients who received greater than 150 mCi when compared with those who received less than 150 mCi (P = .04). Radioactive iodine exposure of over 150 mCi was also associated with a reduction in the recreation domain of the UW-QOL (P = .04), the daily swallowing domain of the MDADI (P = .02), and the psychological/personal, pain, and social domains of the XeQOLS (P = .03, .03, and .04, respectively).
  
  
  CONCLUSIONS
  Patients treated with RAI exhibited an increased risk for sialadenitis as well as a reduction in swallowing-related and global head and neck quality of life. Our findings suggest these patients should be screened for salivary morbidity and may benefit from both pre-RAI prophylaxis and post-RAI intervention.
authors: Department of Otolaryngology-Head and Neck Surgery, University of California, San Diego, California 92130, USA. idingle@ucsd.edu
authors: Isaac F
authors: IF
authors: Dingle
authors: Ashley E
authors: AE
authors: Mishoe
authors: Shaun A
authors: SA
authors: Nguyen
authors: Lewis J
authors: LJ
authors: Overton
authors: M Boyd
authors: MB
authors: Gillespie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003680:Deglutition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012189:Retrospective Studies; D012793:Sialadenitis / Q000209:etiology*; D011795:Surveys and Questionnaires; D013964:Thyroid Neoplasms / Q000532:radiotherapy*; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes