title: HLA Class I and II study in a mestizo family with high incidence of autoimmune disease.
abstract: There are many factors that influence the pathogenesis of autoimmune disease of which host genetic factors play an important role. The aim of this study was to investigate the HLA Class I and II genes in a family with a high incidence of AID to establish whether they contribute to the development of these disease. Four of them had been diagnosed with SLE and one with AHA. The patients with SLE showed the presence of HLA-A*02 B*40 DRB1*04:07 DQB1*03:02 haplotype with a high statistical significance. This haplotype was not present in the healthy individuals and in the patient with AHA, although the DRB1*04:07 DQB1*03:02 haplotype (carried by both parents) was found in the AHA patients and one of the healthy individuals. We must consider how HLA Class I in linkage disequilibrium with HLA Class II may be involved in susceptibility or in the development of SLE. An extensive study in this population should be conducted to establish the true participation of the HLA Class I region.
authors: Molecular Genetics and Histocompatibility Department, Julio C. Perrando Hospital, Resistencia, Chaco, Argentina. Electronic address: Aliciamariahabegger@gmail.com.
authors: Alicia Habegger
authors: AH
authors: de Sorrentino
authors: Marcela
authors: M
authors: Young
authors: Karina
authors: K
authors: Marinic
authors: Patricia Fabiana
authors: PF
authors: Motta
authors: Carlos
authors: C
authors: Baruzzo
mesh_terms: D000328:Adult; D000368:Aged; D001118:Argentina / Q000453:epidemiology; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D044469:Racial Groups
keywords: Antígenos leucocitarios humanos Clase I y II; Autoimmune disease; Enfermedad autoinmunitaria; Familia mestiza; Genetics; Genética; Human leukocyte antigen Class I and II; Lupus eritematoso sistémico; Mestizo family; Systemic lupus erithematous