title: pH-sensitive nanocargo based on smart polymer functionalized graphene oxide for site-specific drug delivery.
abstract: Graphene oxide (GO) was functionalized covalently with pH-sensitive poly(2-(diethylamino) ethyl methacrylate) (PDEA) by surface-initiated in situ atom transfer radical polymerization. The structure of the PDEA-grafted GO (GO-PDEA) were examined by Fourier-transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis and atomic force microscopy. The grafted PDEA endowed the GO sheets with good solubility and stability in physiological solutions. Simple physisorption by π-π stacking and hydrophobic interactions on GO-PDEA can be used to load camptothecin (CPT), a widely used water-insoluble cancer drug. The loaded CPT was released only at the lower (acidic) pH normally found in a tumor environment but not in basic and neutral pH. GO-PDEA did not show practical toxicity to N2a cancer cells but the GO-PDEA-CPT complex exhibited high potency in killing N2a cancer cells in vitro. These results suggest that the GO-PDEA nanocargo carrier might be a promising material for site-specific anticancer drug delivery and controlled release.
authors: Department of Polymer Science and Engineering, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors: Thangavelu
authors: T
authors: Kavitha
authors: Syed Izhar Haider
authors: SI
authors: Abdi
authors: Soo-Young
authors: SY
authors: Park
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D009757:Nylons / Q000737:chemistry / Q000494:pharmacology*; D010087:Oxides / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D008689:Methacrylates; D009757:Nylons; D010087:Oxides; C109846:poly(2-(diethylamino)ethyl methacrylate); D006108:Graphite