title: Cancer of unknown primary sites: what radiologists need to know and what oncologists want to know.
abstract: OBJECTIVE
  In this article, we review the role of imaging in cancer of unknown primary site (CUP) diagnosis and management and the utility of immunohistochemistry, serum tumor markers, and molecular profiling in the optimized care of CUP patients.
  
  
  CONCLUSIONS
  With advances in imaging, pathology, and molecular medicine, the diagnosis and management of CUP have evolved into more personalized and site-specific therapies. A multidisciplinary integrated approach among oncologists, pathologists, and radiologists is extremely important.
authors: Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USA. medimash@gmail.com
authors: Kyung Won
authors: KW
authors: Kim
authors: Katherine M
authors: KM
authors: Krajewski
authors: Jyothi P
authors: JP
authors: Jagannathan
authors: Mizuki
authors: M
authors: Nishino
authors: Atul B
authors: AB
authors: Shinagare
authors: Jason L
authors: JL
authors: Hornick
authors: Nikhil H
authors: NH
authors: Ramaiya
mesh_terms: D003952:Diagnostic Imaging / Q000639:trends*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis*; D057089:Pathology, Molecular / Q000639:trends*