title: Effects of green tea polyphenols on iodide-induced autoimmune thyroiditis in nonobese diabetic mice.
abstract: Because green tea polyphenols (GTPs) possess anti-inflammatory properties and are effective in inhibiting autoimmune diseases in experimental settings, we examined whether GTPs prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic (NOD) mice, an animal model of Hashimoto's thyroiditis (HT). Mice were given 0.05% iodide water or iodide water supplemented with 0.2% GTPs for 8 weeks. GTPs administration led to an enhanced production of interleukin-10 by concanavalin A-stimulated splenocytes but did not interfere with thyroiditis development. Serum thyroxine levels were not influenced by GTPs. Our data suggest that administration of GTPs may not be an effective strategy for the prevention of HT.
authors: Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan.
authors: Saeko
authors: S
authors: Hoshikawa
authors: Yoshinori
authors: Y
authors: Nakagawa
authors: Hiroshi
authors: H
authors: Ozaki
authors: Yurie
authors: Y
authors: Takahashi
authors: Sadayoshi
authors: S
authors: Ito
authors: Katsumi
authors: K
authors: Yoshida
authors: Kouki
authors: K
authors: Mori
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D050031:Hashimoto Disease / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007454:Iodides / Q000008:administration & dosage; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D059808:Polyphenols / Q000008:administration & dosage*; D013662:Tea / Q000737:chemistry*; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control
chemical_list: D007454:Iodides; D059808:Polyphenols; D013662:Tea