title: A review of contemporary data on surgically resected renal masses--benign or malignant?
abstract: OBJECTIVE
  To clearly define the proportions of benign vs malignant histologic findings in resected renal masses through an in-depth review of the contemporary medical data to assist in preoperative risk assessment.
  
  
  METHODS
  PubMed and select oncology congresses were searched for publications that identify the histologic classification of resected renal masses in a representative sample from the contemporary data: [search] incidence AND (renal cell carcinoma AND benign); incidence AND (renal tumor AND benign); percentage AND (renal cell carcinoma AND benign); limit 2003-2011.
  
  
  RESULTS
  We identified 26 representative studies meeting the inclusion criteria and incorporating 27,272 patients. The frequency of benign tumors ranged from 7% to 33%, with most studies within a few percentage points of the mean (14.5% ± 5.2%, median 13.9%). Clear cell renal cell carcinoma occurred in 46% to 83% of patients, with a mean of 68.3% (median 61.3; SD = 11.9%). An inverse relationship between tumor size and benign pathologic features was identified in 14 of 19 (74%) studies that examined an association between tumor size and pathologic characteristics. A statistically significant correlation between clear cell renal cell carcinoma and tumor size was identified in 13 of 19 studies (63%). The accuracy of preoperative cross-sectional imaging was low in the 2 studies examining computed tomography (17%).
  
  
  CONCLUSIONS
  Benign renal tumors represent ∼15% of detected surgically resected renal masses and are more prevalent among small clinical T1a lesions. Noninvasive preoperative differentiation between more and less aggressive renal masses would be an important clinical advance that could allow clinicians greater diagnostic confidence and guide patient management through improved risk stratification.
authors: Division of Urology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors: Anthony T
authors: AT
authors: Corcoran
authors: Paul
authors: P
authors: Russo
authors: William T
authors: WT
authors: Lowrance
authors: Aviva
authors: A
authors: Asnis-Alibozek
authors: John A
authors: JA
authors: Libertino
authors: Daniel A
authors: DA
authors: Pryma
authors: Chaitanya R
authors: CR
authors: Divgi
authors: Robert G
authors: RG
authors: Uzzo
mesh_terms: D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery*; D018570:Risk Assessment