title: Efficacy and acceptability of early mifepristone-misoprostol medical abortion in Ukraine: results of two clinical trials.
abstract: BACKGROUND
  Abortion services are legally available in Ukraine although there are issues in quality and access. Two studies were conducted in Ukraine to expand options for women, and to determine the efficacy and acceptability of medical abortion.
  
  
  METHODS
  Two open-label clinical trials were conducted at six clinics in Ukraine. Women were given 200 mg mifepristone followed after 48 hours by 400 μg oral misoprostol (Study One) and mifepristone followed after 24 hours by 400 μg sublingual misoprostol (Study Two). Follow-up visits were scheduled for two weeks after mifepristone administration to assess whether complete uterine evacuation had occurred.
  
  
  RESULTS
  Success rates were 97% in the first study and 98% in the second one. The vast majority of participants were satisfied or very satisfied with their abortion method (Study One: 94%; Study Two: 98%).
  
  
  CONCLUSIONS
  The two studies demonstrate high rates of success and acceptability of early medical abortion in Ukraine.
authors: Gynuity Health Projects, New York, NY 10010, USA. sraghavan@gynuity.org
authors: Sheila
authors: S
authors: Raghavan
authors: Galina
authors: G
authors: Maistruk
authors: Tara
authors: T
authors: Shochet
authors: Vladimir
authors: V
authors: Bannikov
authors: Svetlana
authors: S
authors: Posohova
authors: Svetlana
authors: S
authors: Zhuk
authors: Vladimir
authors: V
authors: Lishchuk
authors: Beverly
authors: B
authors: Winikoff
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods*; D000282:Administration, Intravaginal; D000286:Administration, Sublingual; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D010342:Patient Acceptance of Health Care / Q000523:psychology*; D011247:Pregnancy; D011446:Prospective Studies; D012646:Self Administration / Q000379:methods; D014455:Ukraine; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D016595:Misoprostol; D015735:Mifepristone