title: Association between milder brain deformation before a shunt operation and improvement in cognition and gait in idiopathic normal pressure hydrocephalus.
abstract: We investigated the association between the degree of deformation of the brain before shunt operation and improvement of gait and cognitive impairment after shunt operation in 16 patients with idiopathic normal pressure hydrocephalus (iNPH). We evaluated gait and cognitive impairment and measured the cerebrospinal fluid volume in the ventricles/sylvian fissure (vVS) and the subarachnoid space at high convexity/midline areas (vHCM) using MR images with voxel-based morphometry before and 3 months after shunt operation. We used the ratio of vVS to vHCM (vVS/vHCM) as an index of the severity of brain deformation. After shunt operation, improvements were observed in gait, as shown by the Timed Up and Go (TUG) test and 10-meter reciprocating walking test (WT), and in cognitive function, as shown by the Mini-Mental State Examination, Alzheimer Disease Assessment Scale, Frontal Assessment battery (FAB), and Trail Making test A (TMT-A). The vVS/vHCM ratio was negatively correlated with improvement of the FAB, TMT-A and TUG. Preoperative vVS/vHCM was not significantly correlated with preoperative clinical assessments. The rate of change of vVS/vHCM was positively correlated with improvement in the WT. The improvements of gait and cognitive function were larger in iNPH patients with milder deformation of the brain before shunt operation.
authors: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan.
authors: Daisuke
authors: D
authors: Yamamoto
authors: Hiroaki
authors: H
authors: Kazui
authors: Tamiki
authors: T
authors: Wada
authors: Keiko
authors: K
authors: Nomura
authors: Hiromichi
authors: H
authors: Sugiyama
authors: Yoshiro
authors: Y
authors: Shimizu
authors: Kenji
authors: K
authors: Yoshiyama
authors: Tetsuhiko
authors: T
authors: Yoshida
authors: Haruhiko
authors: H
authors: Kishima
authors: Fumio
authors: F
authors: Yamashita
authors: Toshiki
authors: T
authors: Yoshimine
authors: Masatoshi
authors: M
authors: Takeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology* / Q000601:surgery; D002555:Cerebrospinal Fluid / Q000502:physiology; D002557:Cerebrospinal Fluid Shunts; D060825:Cognitive Dysfunction / Q000209:etiology* / Q000601:surgery; D005260:Female; D005684:Gait / Q000502:physiology*; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D013346:Subarachnoid Space / Q000033:anatomy & histology*