title: Palladium-catalyzed synthesis of aromatic carboxylic acids with silacarboxylic acids.
abstract: Aryl iodides and bromides were easily converted to their corresponding aromatic carboxylic acids via a Pd-catalyzed carbonylation reaction using silacarboxylic acids as an in situ source of carbon monoxide. The reaction conditions were compatible with a wide range of functional groups, and with the aryl iodides, the carbonylation was complete within minutes. The method was adapted to the double and selective isotope labeling of tamibarotene.
authors: Center for Insoluble Protein Structures, Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.
authors: Stig D
authors: SD
authors: Friis
authors: Thomas L
authors: TL
authors: Andersen
authors: Troels
authors: T
authors: Skrydstrup
mesh_terms: D001965:Bromides; D002248:Carbon Monoxide; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D007454:Iodides; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*
chemical_list: D001965:Bromides; D002264:Carboxylic Acids; D006842:Hydrocarbons, Brominated; D006847:Hydrocarbons, Iodinated; D007454:Iodides; D012821:Silanes; D010165:Palladium; D002248:Carbon Monoxide