title: Cytotoxic activities of some novel benzhydrylpiperazine derivatives.
abstract: This study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4-benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide derivatives had high cytotoxic activity whereas sulfonamide derivatives showed variable 50% growth inhibition (GI50).
authors: Department of Pharmaceutical Chemistry, Yeditepe University, Istanbul, Turkey. egurdal@yeditepe.edu.tr
authors: E E
authors: EE
authors: Gurdal
authors: M
authors: M
authors: Yarim
authors: I
authors: I
authors: Durmaz
authors: R
authors: R
authors: Cetin-Atalay
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001559:Benzhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012235:Rhodamines; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001559:Benzhydryl Compounds; D005456:Fluorescent Dyes; D010879:Piperazines; D012235:Rhodamines; D013449:Sulfonamides; C022027:lissamine rhodamine B