title: U-500R and aspart insulin for the treatment of severe insulin resistance in pregnancy associated with pregestational diabetes.
abstract: Severe insulin resistance as a complication of diabetes in pregnancy is seen with increasing frequency. Treatment with large doses of insulin (>300 units perday) can be practically difficult. A woman with preexisting Type 2 diabetes mellitus and poor glycemic control presented in early pregnancy requiring over 1000 units of insulin daily. She was transitioned to subcutaneous U-500 (concentrated regular insulin) in combination with a rapid-acting insulin analog achieving good glycemic control and good maternal and fetal outcomes. U-500R insulin in conjunction with a rapid-acting insulin analog can be used safely in early pregnancy to improve glycemic control in severe insulin resistance due to pregestational diabetes.
authors: Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco and San Francisco General Hospital, San Francisco, CA 94110, USA.
authors: I
authors: I
authors: Okeigwe
authors: A
authors: A
authors: Yeaton-Massey
authors: S
authors: S
authors: Kim
authors: J E
authors: JE
authors: Vargas
authors: E J
authors: EJ
authors: Murphy
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015897:Comorbidity; D016640:Diabetes, Gestational / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007328:Insulin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D061267:Insulin Aspart / Q000627:therapeutic use*; D007333:Insulin Resistance / Q000502:physiology; D009767:Obesity, Morbid / Q000453:epidemiology / Q000503:physiopathology; D011247:Pregnancy
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D061267:Insulin Aspart