title: Striational antibodies in a paraneoplastic context.
abstract: BACKGROUND
  The clinical significance of striational antibodies (StrAbs) detected in the course of paraneoplastic antibody testing is unknown.
  
  
  METHODS
  We compared all 203 striational antibody (StrAb)-seropositive patients identified (2004-2005) during evaluation for paraneoplastic antibodies with age- and sex-matched seronegative controls.
  
  
  RESULTS
  Thymoma and myasthenia gravis (MG) were significantly more common among cases (P<0.0001). Cancers more rarely detected after StrAb detection were adenocarcinoma in 5 patients and sarcoma in 3 patients. All patients who had a cancer identified after StrAb testing had a titer of ≥ 1:7680 or a coexisting muscle AChR-binding antibody. Autoimmune disorders more commonly observed among cases (with any StrAb value) included: hypothyroidism; rheumatoid arthritis; and pernicious anemia (all P<0.05).
  
  
  CONCLUSIONS
  StrAbs may serve as a diagnostic clue for an autoimmune diagnosis. There is a low likelihood of oncological significance in patients with StrAb titers <1:7680 without coexisting paraneoplastic Abs.
authors: Department of Medicine and Pathology, Mayo Clinic, Hilton 3-78, 200 First Street SW, Rochester, Minnesota 55905, USA. mckeon.andrew@mayo.edu
authors: Andrew
authors: A
authors: McKeon
authors: Vanda A
authors: VA
authors: Lennon
authors: Daniel H
authors: DH
authors: LaChance
authors: Christopher J
authors: CJ
authors: Klein
authors: Sean J
authors: SJ
authors: Pittock
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000276:immunology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000276:immunology*; D009157:Myasthenia Gravis / Q000209:etiology / Q000276:immunology; D009369:Neoplasms / Q000150:complications / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000276:immunology*; D012189:Retrospective Studies; D012509:Sarcoma / Q000150:complications / Q000276:immunology; D013945:Thymoma / Q000150:complications / Q000276:immunology; D013953:Thymus Neoplasms / Q000150:complications / Q000276:immunology
chemical_list: D001323:Autoantibodies; D009124:Muscle Proteins