title: Methodological issues in clinical drug development for essential tremor.
abstract: Essential tremor (ET) is one of the most common tremor disorders in the world. Despite this, only two medications have received Level A recommendations from the American Academy of Neurology to treat it (primidone and propranolol). Even though these medications provide relief to a large group of ET patients, up to 50% of patients are non-responders. Additional medications to treat ET are needed. This review discusses some of the methodological issues that should be addressed for quality clinical drug development in ET.
authors: Department of Neurology, University of South Florida, Tampa, Florida, United States of America.
authors: Michael A
authors: MA
authors: Carranza
authors: Madeline R
authors: MR
authors: Snyder
authors: Rodger J
authors: RJ
authors: Elble
authors: Angelique E
authors: AE
authors: Boutzoukas
authors: Theresa A
authors: TA
authors: Zesiewicz
keywords: Essential tremor; etiology; methodology; tremor