title: Nanoparticle accumulation in angiogenic tissues: towards predictable pharmacokinetics.
abstract: Nanoparticles are increasingly used in medical applications such as drug delivery, imaging, and biodiagnostics, particularly for cancer. The design of nanoparticles for tumor delivery has been largely empirical, owing to a lack of quantitative data on angiogenic tissue sequestration. Using fluorescence correlation spectroscopy, the deposition rate constants of nanoparticles into angiogenic blood vessel tissue are determined. It is shown that deposition is dependent on surface charge. Moreover, the size dependency strongly suggests that nanoparticles are taken up by a passive mechanism that depends largely on geometry. These findings imply that it is possible to tune nanoparticle pharmacokinetics simply by adjusting nanoparticle size.
authors: Department of Chemistry, 2500 University Dr NW, University of Calgary, Calgary, Alberta, Canada, T2N 1N4.
authors: Kristin
authors: K
authors: Yaehne
authors: Amy
authors: A
authors: Tekrony
authors: Aisling
authors: A
authors: Clancy
authors: Yiota
authors: Y
authors: Gregoriou
authors: John
authors: J
authors: Walker
authors: Kwin
authors: K
authors: Dean
authors: Trinh
authors: T
authors: Nguyen
authors: Amber
authors: A
authors: Doiron
authors: Kristina
authors: K
authors: Rinker
authors: Xiao Yu
authors: XY
authors: Jiang
authors: Sarah
authors: S
authors: Childs
authors: David
authors: D
authors: Cramb
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D004337:Drug Carriers
keywords: angiogenesis; drug delivery; embryos; nanoparticles; pharmacokinetics