title: Extensive multiarterial resection attending total duodenopancreatectomy and adrenalectomy for MEN-1-associated neuroendocrine carcinomas.
abstract: Pancreatic neuroendocrine tumors (PNTs) are relatively uncommon although these neoplasms have been noted to grow in occurrence in recent decades. Surgical removal of locally advanced PNTs involving major vessels and adjacent organs is warranted by reason of an appreciably more favorable prognosis as compared to exocrine pancreas cancer. We are reporting a case of successful multi-organ resection combined with a wide excision of the superior mesenteric, common, proper, left and right hepatic arteries (in the presence of the hepatomesenteric trunk variant of aberrant arterial anatomy) for multifocal PNTs in the setting of multiple neuroendocrine neoplasia type 1 syndrome. The procedure resulted in pain abolition, a significant improvement in the patient's life quality and allowed her to return to work. Follow-up computed tomography at 15 mo post-surgery showed no evidence of disease recurrence.
authors: Vyacheslav Ivanovich Egorov, Sechenov First State Medical University, Ostroumov 14th City Hospital, Department of Surgical Oncology, 117997 Moscow, Russia.
authors: Vyacheslav Ivanovich
authors: VI
authors: Egorov
authors: Alexander Felixovich
authors: AF
authors: Kharazov
authors: Alla Ivanovna
authors: AI
authors: Pavlovskaya
authors: Roman Valeryevich
authors: RV
authors: Petrov
authors: Natalia Sergeevna
authors: NS
authors: Starostina
authors: Eugeny Valerievich
authors: EV
authors: Kondratiev
authors: Ekaterina Mikhailovna
authors: EM
authors: Filippova
keywords: Islet cell tumors; Multiple endocrine neoplasia type 1 syndrome; Neuroendocrine carcinoma; Pancreatic neuroendocrine tumors; Total duodenopancreatectomy