title: Flurbiprofen-loaded nanoparticles prepared with polyvinylpyrrolidone using Shirasu porous glass membranes and a spray-drying technique: nano-sized formation and improved bioavailability.
abstract: A unique flurbiprofen-loaded nanoemulsion was listed earlier using a Shirasu porous glass (SPG) membrane emulsification technique, which gave constant emulsion droplets with a thin size distribution. In this study, a flurbiprofen-loaded nanoemulsion was developed further into a solid form using polyvinylpyrrolidone (PVP) as a carrier by a spray-drying technique. The flurbiprofen-loaded nanoparticles with a weight ratio of flurbiprofen/PVP/surfactant mixture of 1/8/2 were connected with about 130,000-fold enhanced drug solubility and had a mean size of about 70 nm. In these nanoparticles, flurbiprofen was found in an altered amorphous state. Additionally, the nanoparticles gave significantly shorter T(max), and greater AUC and C(max) compared to the commercially available product. Specially, the AUC of the drug from the nanoparticles was about 10-fold greater compared to the commercially available product. Therefore, these flurbiprofen-loaded nanoparticles can be convenient for distributing a poorly water-soluble flurbiprofen with improved bioavailability using uniform nano-sized particles.
authors: College of Pharmacy, Yeungnam University , Gyongsan , South Korea.
authors: Dong Hoon
authors: DH
authors: Oh
authors: Fakhar Ud
authors: FU
authors: Din
authors: Dong Wuk
authors: DW
authors: Kim
authors: Jong Oh
authors: JO
authors: Kim
authors: Chul Soon
authors: CS
authors: Yong
authors: Han-Gon
authors: HG
authors: Choi
mesh_terms: D000700:Analgesics / Q000008:administration & dosage* / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000097:blood; D003890:Desiccation; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D005480:Flurbiprofen / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D011205:Povidone / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D004655:Emulsions; D005480:Flurbiprofen; D011205:Povidone