title: Biological activities and corresponding SARs of andrographolide and its derivatives.
abstract: In recent years, pharmaceutical chemists have synthesized large numbers of andrographolide derivatives, which bear important biological activities such as anti-inflammatory, antibacterial, antivirus, antitumor, antidiabetic, and antifeedant. Consequently, corresponding SARs were increasingly obvious. This paper aimed to review all the available literature in this field, highlighting the significant achievements on the structural modification and SARs of andrographolide and its derivatives.
authors: Center of Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
authors: Bin
authors: B
authors: Zhou
authors: Dayong
authors: D
authors: Zhang
authors: Xiaoming
authors: X
authors: Wu
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D003920:Diabetes Mellitus / Q000188:drug therapy; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014777:Virus Diseases / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D004224:Diterpenes; D007004:Hypoglycemic Agents; C030419:andrographolide