title: Column chromatography-free solution-phase synthesis of a natural piper-amide-like compound library.
abstract: We have achieved an efficient solution-phase parallel synthesis of a library of natural piper-amide-like compounds from the bifunctional β-phosphono-N-hydroxy-succinimidyl ester intermediate. The primary important feature in our study is the construction of natural-product-like molecules through the adaptation of sophisticated organic reactions that create water-soluble byproducts for a chromatography-free purification. This simple and efficient method rapidly provides a combinatorial library of high yield and purity. The library was evaluated against GPCR targets to demonstrate its potential use as a tool for drug discovery and in chemical biology.
authors: College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
authors: Sumin
authors: S
authors: Kim
authors: Chaemin
authors: C
authors: Lim
authors: Sukjin
authors: S
authors: Lee
authors: Seokwoo
authors: S
authors: Lee
authors: Hyunkyung
authors: H
authors: Cho
authors: Joo-Youn
authors: JY
authors: Lee
authors: Dong Sup
authors: DS
authors: Shim
authors: Hee Dong
authors: HD
authors: Park
authors: Sanghee
authors: S
authors: Kim
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D031701:Piper / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D001688:Biological Products; D054852:Small Molecule Libraries