title: Effect of physical activity on bone strength and body composition in breast cancer premenopausal women during endocrine therapy.
abstract: BACKGROUND
  Breast cancer endocrine therapy (ET) is one of the most basic therapeutic methods in oncology. Well-balanced physical activity exerts positive influence on bone strength (BS) and body composition (BC), which has been confirmed by the clinical research regarding osteoporosis, prevention and treatment alike. Accordingly, in the following study, an attempt was made to assess the selected parameters of young, premenopausal women's clinical state under the influence of breast cancer ET, as well as to define the influence of physical activity on the studied parameters.
  
  
  OBJECTIVE
  The assessment of the influence of aerobic and resistance training (AT and RT) on BS and BC in premenopausal women during breast cancer ET.
  
  
  METHODS
  This was a nonrandomized, prospective clinical study.
  
  
  METHODS
  The study was performed in 41 outpatients in the Greater Poland Cancer Centre.
  
  
  METHODS
  The examinations were made with the anthropometric and dual energy X-ray absorptiometry measurements. The examinations were conducted according to the schedule: at the baseline, II-after 6 months of ET, III-after 6 months of AT (in 12 months of ET), IV- after following 6 months AT and RT (18 months of ET).
  
  
  RESULTS
  After 6 months of the ET without physical activity the bone mineral density (BMD) in all regions and the hip structure parameters were lower in comparison to the baseline and there was a significant increase in fatty tissue. After 6 months of AT the BMD of all regions was lower than in 6 months ET. An introduction of RT caused the analyzed values of BS parameters to increase. Also a significant growth of lean body mass and free fat body mass was observed and so was an insignificant fall in fat.
  
  
  CONCLUSIONS
  The breast cancer ET is related to the changes in BS and BC in premenopausal women. The introduction of AT caused a slowdown in negative changes in bones, and body fat was reduced. The introduction of RT reversed an adverse tendency for BS and sarcopenia.
  
  
  CONCLUSIONS
  The study results show that mixed type physical activity (AT and RT) during breast cancer ET could prevent negative changes, of this treatment, in body build in premenopausal women.
authors: Depatment of Rehabilitation, Greater Poland Cancer Centre, Poznan, Poland. khojan@op.pl
authors: K
authors: K
authors: Hojan
authors: P
authors: P
authors: Milecki
authors: M
authors: M
authors: Molińska-Glura
authors: A
authors: A
authors: Roszak
authors: P
authors: P
authors: Leszczyński
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D001823:Body Composition; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000503:physiopathology*; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D017273:Goserelin / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D017697:Premenopause; D011446:Prospective Studies; D055070:Resistance Training; D013629:Tamoxifen / Q000008:administration & dosage
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen; D017273:Goserelin