title: Complications of targeted drug therapies for solid malignancies: manifestations and mechanisms.
abstract: OBJECTIVE
  This article reviews important complications of targeted drug therapies for solid malignancies that can be identified on diagnostic imaging. Wherever possible, known or proposed mechanistic explanations for drug complications are emphasized.
  
  
  CONCLUSIONS
  Familiarity with the toxicity profiles of different targeted cancer therapies is important for identifying drug-related complications and for differentiating drug effects from disease progression. A mechanistic understanding may be useful for associating individual drugs with their complications and for predicting the complications of emerging agents.
authors: Department of Radiology and Radiological Science, Vanderbilt University School of Medicine, 1161 21st Ave S, CCC-1121 MCN, Nashville, TN 37232-2675, USA. richard.abramson@vanderbilt.edu
authors: Richard G
authors: RG
authors: Abramson
authors: Vandana G
authors: VG
authors: Abramson
authors: Emily
authors: E
authors: Chan
authors: Leora
authors: L
authors: Horn
authors: Vicki L
authors: VL
authors: Keedy
authors: William
authors: W
authors: Pao
authors: Jeffrey A
authors: JA
authors: Sosman
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents