title: Twenty-one years of microemulsion electrokinetic chromatography (1991-2012): a powerful analytical tool.
abstract: Microemulsion electrokinetic chromatography (MEEKC) is a CE separation technique, which utilizes buffered microemulsions as the separation media. In the past two decades, MEEKC has blossomed into a powerful separation technique for the analysis of a wide range of compounds. Pseudostationary phase composition is so critical to successful resolution in EKC, and several variables could be optimized including surfactant/co-surfactant/oil type and concentration, buffer content, and pH value. Additionally, MEEKC coupled with online sample preconcentration approaches could significantly improve the detection sensitivity. This review comprehensively describes the development of MEEKC from the period 1991 to 2012. Areas covered include basic theory, microemulsion composition, improving resolution and enhancing sensitivity methods, detection techniques, and applications of MEEKC.
authors: State Key Laboratory of Natural Medicines (China Pharmaceutical University), Nanjing, PR China.
authors: Hua
authors: H
authors: Yang
authors: Yao
authors: Y
authors: Ding
authors: Jun
authors: J
authors: Cao
authors: Ping
authors: P
authors: Li
mesh_terms: D000818:Animals; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000266:history / Q000295:instrumentation / Q000379:methods*; D004655:Emulsions / Q000737:chemistry; D004867:Equipment Design; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D004655:Emulsions; D013501:Surface-Active Agents