title: A new hydroxychavicol dimer from the roots of Piper betle.
abstract: A new hydroxychavicol dimer, 2-(g'-hydroxychavicol)-hydroxychavicol (1), was isolated from the roots of Piper betle Linn. along with five known compounds, hydroxychavicol (2), aristololactam A II (3), aristololactam B II (4), piperolactam A (5) and cepharadione A (6). The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
authors: Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. cflin@gw.cgust.edu.tw
authors: Chwan-Fwu
authors: CF
authors: Lin
authors: Tsong-Long
authors: TL
authors: Hwang
authors: Chun-Chien
authors: CC
authors: Chien
authors: Huei-Yu
authors: HY
authors: Tu
authors: Horng-Liang
authors: HL
authors: Lay
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D005054:Eugenol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D010196:Pancreatic Elastase / Q000378:metabolism*; D031721:Piper betle / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry*; D013481:Superoxides / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D013481:Superoxides; C051268:2-hydroxychavicol; D005054:Eugenol; D010196:Pancreatic Elastase