title: [The effect of oxymatrine on aging mice caused by D+ -galactose].
abstract: OBJECTIVE
  To investigate the effect of oxymatrine (OMT) on aging mouse caused by D (+)-Galactose.
  
  
  METHODS
  Healthy Kunming mouse were randomly divided into control, model and treated groups. The treated group was divided into three subgroups which were given oxymatrine 5 mg/kg, 10 mg/kg,20 mg/kg (OMT5, OMT10, OMT20). After 30 days of administration,the stand-jumping test and the Morris water maze test of each group were used to observe the learning and memory ability. After the behavior indicators test, 1-2 mL blood were got from ophthalmic vein plexus,and then got the serum by centrifuge. The super oxide dismutase (SOD) activity and malondialdehyde (MDA) content were determined by SOD and MDA kit.
  
  
  RESULTS
  In the water maze test, the model group was significantly longer in the latency than that of the control group (P < 0.01), and the number of the crossing platforms was significantly reduced (P < 0.01), but compared with the model group, the OMT5, OMT10, OMT20 groups were significantly shorter in the latency to the end (P < 0.05, P < 0.05, P < 0.01), and the number of the crossing platforms was significantly increased (P < 0.05, P < 0.05, P < 0.01); In the stand-jumping test,the OMT groups all could extend the platform latency and reduce the error reaction times, the learning ability of the OMT groups was better than the model group, but the statistical tests failed (P > 0.05); In the serum biochemical indicators test,the SOD activity of the model group was significantly lower than that of the control group (P < 0.01), but the SOD activity of OMT5, OMTIO, OMT20 groups was significant higher than that of the model group (P < 0.05, P < 0.05, P < 0.01); The MDA content of the model group was significantly higher than that of the control group (P < 0.01) but the MDA content of OMT5, OMT1O, OMT20 groups was significant lower than that of the model group (P < 0.05, P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  Oxymatrine could improve the learning and memory ability of aging mice caused by intraperitoneal injection D(+)-Galactose,and the anti-aging effect is related to the oxygen free radicals and reducing the lipid peroxidation.
authors: Department of Pharmacology, Xuzhou Medical College, Xuzhou 221004, China.
authors: Xiao-hu
authors: XH
authors: Zi
authors: Wei
authors: W
authors: Zhou
authors: Qian
authors: Q
authors: Chen
authors: Mei
authors: M
authors: Li
authors: Shu-ling
authors: SL
authors: Gu
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D005690:Galactose / Q000009:adverse effects; D007858:Learning / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D011807:Quinolizines / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D029909:Sophora / Q000737:chemistry; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D016896:Treatment Outcome; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D005690:Galactose; D008315:Malondialdehyde; D011807:Quinolizines; D013482:Superoxide Dismutase; C037573:oxymatrine; D000093842:Matrines