title: Mineralocorticoid-receptor signalling in vascular smooth muscle.
abstract: Human data suggest that eplerenone and spironolactone lowers blood pressure by mechanisms independent of the distal tubule. Now, a novel inducible conditional knockout model of the mineralocorticoid receptor (MR) in vascular smooth muscle cells (VSMCs) brings out understanding further.
authors: Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors: Jing
authors: J
authors: Wu
authors: Friedrich C
authors: FC
authors: Luft
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D018161:Receptors, Mineralocorticoid / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D018161:Receptors, Mineralocorticoid
keywords: LoxP; aldosterone; cre recombinase; hypertension; mineralocorticoid receptor