title: Prevention of topical surfactant-induced itch-related responses by chlorogenic acid through the inhibition of increased histamine production in the epidermis.
abstract: Effects of chlorogenic acid on surfactant-induced itching were studied in mice. Topical application of sodium laurate increased hind-paw scratching, an itch-related response, 2 h after application, which was inhibited by topical post-treatment with chlorogenic acid. Sodium laurate increased the histamine content and 53-kDa L-histidine decarboxylase in the epidermis, which were also inhibited by post-treatment with chlorogenic acid. These results suggest that topical chlorogenic acid is effective in the prevention of itching induced by anionic surfactants. The inhibitory activity of chlorogenic acid may be due to the inhibition of an increase in histamine in the epidermis.
authors: Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
authors: Yoshihiro
authors: Y
authors: Inami
authors: Tsugunobu
authors: T
authors: Andoh
authors: Yasushi
authors: Y
authors: Kuraishi
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002726:Chlorogenic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D004817:Epidermis / Q000201:enzymology / Q000378:metabolism*; D006632:Histamine / Q000096:biosynthesis*; D006636:Histamine Release / Q000187:drug effects*; D006640:Histidine Decarboxylase / Q000378:metabolism; D007850:Lauric Acids / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011537:Pruritus / Q000139:chemically induced / Q000517:prevention & control*; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D007850:Lauric Acids; D013501:Surface-Active Agents; C030358:lauric acid; D002726:Chlorogenic Acid; D006632:Histamine; D006640:Histidine Decarboxylase