title: In vivo measurement of the average refractive index of the human crystalline lens using optical coherence tomography.
abstract: We present a method for measuring the average group refractive index of the human crystalline lens in vivo using an optical coherence tomography (OCT) system which, allows full-length biometry of the eye. A series of OCT images of the eye including the anterior segment and retina were recorded during accommodation. Optical lengths of the anterior chamber, lens, and vitreous were measured dynamically along the central axis on the OCT images. The group refractive index of the crystalline lens along the central axis was determined using linear regression analysis of the intraocular optical length measurements. Measurements were acquired on three subjects of age 21, 24, and 35 years. The average group refractive index for the three subjects was, respectively, n=1.41, 1.43, and 1.39 at 835 nm.
authors: Ophthalmic Biophysics Center, Bascom Palmer Eye Institute-University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
authors: Carolina
authors: C
authors: de Freitas
authors: Marco
authors: M
authors: Ruggeri
authors: Fabrice
authors: F
authors: Manns
authors: Arthur
authors: A
authors: Ho
authors: Jean-Marie
authors: JM
authors: Parel
mesh_terms: D000065:Accommodation, Ocular; D000328:Adult; D000465:Algorithms; D001699:Biometry / Q000379:methods; D006801:Humans; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000502:physiology*; D015233:Models, Statistical; D012029:Refraction, Ocular / Q000502:physiology*; D012031:Refractometry; D012160:Retina / Q000033:anatomy & histology / Q000502:physiology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014785:Vision, Ocular