title: Screening and risk stratification for Barrett's esophagus: how to limit the clinical impact of the increasing incidence of esophageal adenocarcinoma.
abstract: Barrett's esophagus (BE) and gastroesophageal reflux disease are the strongest risk factors for esophageal adenocarcinoma. To reduce the clinical impact of this disease, endoscopic screening to detect BE has been proposed and nonendoscopic diagnostic techniques are under investigation. Because screening would result in new diagnoses of BE and additional costs related to endoscopic surveillance, novel tools for risk stratification are also warranted. Dysplasia is the gold standard for risk stratification. Molecular biomarkers may provide a more objective and reproducible estimation of the individual risk, and further prospective studies are required as a prelude to introducing biomarkers into routine clinical practice.
authors: MRC Cancer Cell Unit, Hutchison MRC, Hills Road, Cambridge CB2 0XZ, UK.
authors: Massimiliano
authors: M
authors: di Pietro
authors: Rebecca C
authors: RC
authors: Fitzgerald
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology; D000428:Alcohol Drinking; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D004938:Esophageal Neoplasms / Q000453:epidemiology; D004945:Esophagoscopy; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D016481:Helicobacter Infections; D006801:Humans; D008297:Male; D009765:Obesity; D011230:Precancerous Conditions; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking