title: Functional and effective connectivity in EEG alpha and beta bands during intermittent flash stimulation in migraine with and without aura.
abstract: OBJECTIVE
  This research was a case-control study to evaluate functional and effective connectivity patterns in ongoing electroencephalography (EEG) under repetitive photic stimulation in the interictal phase of migraine patients with and without aura compared to nonmigraine controls.
  
  
  METHODS
  EEG was recorded by six scalp electrodes from 19 migraine without aura patients (MO), 19 migraine with aura patients (MA) and 11 healthy subjects (control group (N)). Flash stimuli were presented at 9-27 Hz frequencies. Phase synchronization after Hilbert transform and Granger causality were evaluated filtering the EEG in alpha and beta bands.
  
  
  RESULTS
  Phase synchronization increased in alpha band in MO, and decreased in beta band in MA, with respect to controls. The intensity of directed interactions in beta band, revealed by Granger causality, increased in MA compared to both MO patients and controls.
  
  
  CONCLUSIONS
  There were clear differences in ongoing EEG under visual stimulation, which emerged between the two forms of migraine, probably subtended by increased cortical activation in migraine with aura, and compensatory phenomena of reduced connectivity and functional networks segregation, occurring in patients not experiencing aura symptoms. Further investigation may confirm whether the clinical manifestation of aura symptoms is subtended by a peculiar neuronal connectivity pattern.
authors: Dipartimento di Neuroscienze e Organi di senso, Università degli Studi di Bari Aldo Moro, Italy. marina.detommaso@uniba.it
authors: Marina
authors: M
authors: de Tommaso
authors: Sebastiano
authors: S
authors: Stramaglia
authors: Daniele
authors: D
authors: Marinazzo
authors: Gabriele
authors: G
authors: Trotta
authors: Mario
authors: M
authors: Pellicoro
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology*; D010775:Photic Stimulation; D055815:Young Adult
keywords: Granger causality; Migraine with and without aura; alpha and beta bands; intermittent flash stimulation; phase synchronization