title: [State of thiol exchange in patients with psoriasis and its possible correction].
abstract: Experiments on erythrocytes of patients were used to study the influence of remaxol and ademetionin on the exchange of thiols. The values of thioldisulfide exchange indicators were determined in the beginning of the period of observation and at the end of every week within one month. Patients who received hepato-protectors in combination with higher-level thiols showed positive dynamics in disease treatment as compared to patients receiving standard therapy. The concentration of restored glutathione and proteins of hydrosulfide groups and the activity of glutathione peroxidase are informative criteria for estimating the course of disease current and the efficiency of therapy of widespread forms of psoriasis.
authors: R A
authors: RA
authors: Grashin
authors: A V
authors: AV
authors: Poliakova
authors: I N
authors: IN
authors: Telichko
mesh_terms: D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use; D002125:Calcium Gluconate / Q000494:pharmacology / Q000627:therapeutic use; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005492:Folic Acid / Q000494:pharmacology / Q000627:therapeutic use; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D012436:S-Adenosylmethionine / Q000494:pharmacology / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013386:Succinates / Q000494:pharmacology / Q000627:therapeutic use*; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D014805:Vitamin B 12 / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C555877:Remaxol; D013386:Succinates; D013438:Sulfhydryl Compounds; D012436:S-Adenosylmethionine; D005492:Folic Acid; D005979:Glutathione Peroxidase; D005978:Glutathione; D014805:Vitamin B 12; D001205:Ascorbic Acid; D002125:Calcium Gluconate