title: Surgery for scoliosis in Duchenne muscular dystrophy.
abstract: BACKGROUND
  Scoliosis in people with Duchenne muscular dystrophy is usually progressive and treated with surgery. However, it is unclear whether the existing evidence is sufficiently scientifically rigorous to support a recommendation for spinal surgery for most people with Duchenne muscular dystrophy and scoliosis. This is an updated review and an updated search was undertaken in which no new studies were found.
  
  
  OBJECTIVE
  To determine the effectiveness and safety of spinal surgery in people with Duchenne muscular dystrophy with scoliosis. We intended to test whether spinal surgery is effective in increasing survival, improving respiratory function, improving quality of life and overall functioning; and whether spinal surgery is associated with severe adverse effects.
  
  
  METHODS
  We searched the specialized registers of the Cochrane Neuromuscular Disease Group (31 July 2012), MEDLINE (January 1966 to July 2012), EMBASE (January 1947 to July 2012), CENTRAL (2012, Issue 7 in the Cochrane Library), CINAHL Plus(January 1937 to July 2012), Proquest Dissertation and Thesis Database (January 1980 to July 2012), and the National Institute of Health Clinical Trials Database (July 2012). No language restrictions were imposed.
  
  
  METHODS
  We planned to include controlled clinical trials using random or quasi-random allocation of treatment evaluating all forms of spinal surgery for scoliosis in people with Duchenne muscular dystrophy in the review. The control interventions would have been no treatment, non-operative treatment, or a different form of spinal surgery.
  
  
  METHODS
  Two authors independently examined the search results and evaluated the study characteristics against inclusion criteria to decide which ones would be included in the review.
  
  
  RESULTS
  On searching, 47 studies were relevant but none met the inclusion criteria for the review, because they were not clinical trials but prospective or retrospective reviews of case series.
  
  
  CONCLUSIONS
  Since there were no randomized controlled clinical trials available to evaluate the effectiveness of scoliosis surgery in people with Duchenne muscular dystrophy, no evidence-based recommendation can be made for clinical practice. People with scoliosis should be informed about the uncertainty of benefits and potential risks of surgery for scoliosis. Randomized controlled trials are needed to investigate the effectiveness of scoliosis surgery, in terms of quality of life, functional status, respiratory function and life expectancy.
authors: Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. cheukkld@hkucc.hku.hk.
authors: Daniel K L
authors: DK
authors: Cheuk
authors: Virginia
authors: V
authors: Wong
authors: Elizabeth
authors: E
authors: Wraige
authors: Peter
authors: P
authors: Baxter
authors: Ashley
authors: A
authors: Cole
mesh_terms: D006801:Humans; D020388:Muscular Dystrophy, Duchenne / Q000150:complications*; D012600:Scoliosis / Q000150:complications / Q000601:surgery*; D013131:Spine / Q000601:surgery