title: Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats.
abstract: The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.
authors: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors: Soung Baek
authors: SB
authors: Jang
authors: Dongju
authors: D
authors: Kim
authors: Seong Yeon
authors: SY
authors: Kim
authors: Changhee
authors: C
authors: Park
authors: Ji Hoon
authors: JH
authors: Jeong
authors: Hyo-Jeong
authors: HJ
authors: Kuh
authors: Jaehwi
authors: J
authors: Lee
keywords: Beta-lapachone; Mixed micelles; Permeability; Single-pass intestinal perfusion