title: Enzymatically generated hydrogen peroxide reduces the number of acne lesions in acne vulgaris.
abstract: A major component to the etiology of acne is the growth and invasion by Propionibacterium acnes. Hydrogen peroxide is an excellent antimicrobial agent but is unstable in most formulations. We have developed a hydrogen peroxide generation system using the enzyme glucose oxidase and glucose. This system is stable in a simple formulation and nonirritating. In a short-term clinical study (4 days), this formulation was effective in reducing the individual lesion size and total number of inflammatory acne lesions. There was a 68% reduction in acne-induced inflammation and 61% reduction in acne size within 4 days of treatment. A long-term clinical study (6 weeks in use) displayed 56% reduction in total number of inflamed lesions and a 45% reduction in noninflamed lesions after 6 weeks. This suggests that topical enzymatically generated hydrogen peroxide may help alleviate acne.
authors: Estèe Lauder Companies, Melville, NY, USA.
authors: Neelam
authors: N
authors: Muizzuddin
authors: Steven
authors: S
authors: Schnittger
authors: Wanda
authors: W
authors: Maher
authors: Daniel H
authors: DH
authors: Maes
authors: Thomas
authors: T
authors: Mammone
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D001585:Benzoyl Peroxide; D002626:Chemistry, Pharmaceutical; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D006861:Hydrogen Peroxide; D005949:Glucose Oxidase; D005947:Glucose; D001585:Benzoyl Peroxide