title: New flavonol and diterpenoids from the endophytic fungus Aspergillus sp. YXf3.
abstract: One new flavonol, chlorflavonin A (1), four new diterpenoids, aspergiloids E-H (3, 5-7), together with eight known compounds (2, 4, 8-13) were isolated from solid fermentation of Aspergillus sp. (strain no. YXf3), an endophytic fungus from Ginkgo biloba. Their structures were determined through detailed spectroscopic analysis combined with comparison of NMR spectra data with reported ones. All of them were screened on cytotoxicity against KB, SGC-7901, SW1116, and A549 cell lines; compounds 4, 9-11 exhibited moderate activities with IC50 values ranging from 6.74 to 46.64 µM.
authors: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
authors: Tong
authors: T
authors: Yan
authors: Zhi Kai
authors: ZK
authors: Guo
authors: Rong
authors: R
authors: Jiang
authors: Wei
authors: W
authors: Wei
authors: Ting
authors: T
authors: Wang
authors: Ye
authors: Y
authors: Guo
authors: Yong Chun
authors: YC
authors: Song
authors: Rui Hua
authors: RH
authors: Jiao
authors: Ren Xiang
authors: RX
authors: Tan
authors: Hui Ming
authors: HM
authors: Ge
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis*; D001230:Aspergillus / Q000737:chemistry*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification*; D020441:Ginkgo biloba / Q000382:microbiology; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D044948:Flavonols