title: Calorimetric evaluation of interaction and absorption of polychlorinated biphenyls by biomembrane models.
abstract: Polychlorinated biphenyls (PCBs) are organic pollutants with lipophilic properties, due to their persistence, they are present in environment at potentially dangerous concentrations for humans health. In this work we investigated the interaction and absorption of 2,4,4'-trichlorobiphenyl (PCB 28), 2,3,3',4,4'-pentachlorobiphenyl (PCB 105) and 2,3,3',4,4',5,5'-eptachlorobiphenyl (PCB 189) with dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLV), chosen as biomembrane models, by differential scanning calorimetry technique (DSC). The obtained results indicate that the tested compounds affected the thermotropic behaviour of MLV to different degree, modifying the phase transition peak and shifting it towards lower temperature. The effect of an aqueous or lipophilic medium on the absorption process of these compounds by the biomembrane models was also investigated revealing that the process is hindered by the aqueous medium but favoured by the lipophilic medium.
authors: Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, Catania, Italy.
authors: Vito
authors: V
authors: Librando
authors: Zelica
authors: Z
authors: Minniti
authors: Maria Lorena
authors: ML
authors: Accolla
authors: Orazio
authors: O
authors: Cascioc
authors: Francesco
authors: F
authors: Castelli
authors: Maria Grazia
authors: MG
authors: Sarpietro
mesh_terms: D000042:Absorption; D002152:Calorimetry, Differential Scanning; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D004785:Environmental Pollutants / Q000737:chemistry*; D008567:Membranes, Artificial; D011078:Polychlorinated Biphenyls / Q000737:chemistry*; D013816:Thermodynamics; D044366:Transition Temperature
chemical_list: D004785:Environmental Pollutants; D008567:Membranes, Artificial; D011078:Polychlorinated Biphenyls; D004134:Dimyristoylphosphatidylcholine