title: Response of meningeal carcinomatosis from breast cancer to capecitabine monotherapy: a case report.
abstract: A 62-year-old woman with breast cancer received neoadjuvant chemotherapy followed by breast-conserving surgery and sentinel node biopsy. During adjuvant endocrine therapy with aromatase inhibitor, she developed multiple bone metastases. Thereafter, she received tamoxifen and zoledronate therapy. In May 2011, she developed a tongue deviation and was diagnosed as having meningeal carcinomatosis. The tongue deviation disappeared 3 weeks after taking capecitabine (2,400 mg/day). Magnetic resonance imaging of the brain showed regression of meningeal carcinomatosis. Levels of tumor markers CEA and CA15-3 changed from 96.0 IU/ml and 3.5 ng/ml to 47.0 IU/ml and 1.5 ng/ml, respectively. Progression-free survival with capecitabine monotherapy was 5 months.
authors: Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, Wakayama, Japan.
authors: Yumi
authors: Y
authors: Tanaka
authors: Shoji
authors: S
authors: Oura
authors: Tatsuya
authors: T
authors: Yoshimasu
authors: Fuminori
authors: F
authors: Ohta
authors: Koma
authors: K
authors: Naito
authors: Rie
authors: R
authors: Nakamura
authors: Yoshimitsu
authors: Y
authors: Hirai
authors: Masako
authors: M
authors: Ikeda
authors: Yoshitaka
authors: Y
authors: Okamura
keywords: Breast cancer; Capecitabine; Meningeal carcinomatosis