title: The effect of trazodone on standardized field sobriety tests.
abstract: OBJECTIVE
  To evaluate the effects of a single dose of trazodone on the standardized field sobriety test (SFST).
  
  
  METHODS
  A randomized, double-blinded, repeated-measures study.
  
  
  METHODS
  Forty-five healthy adult subjects.
  
  
  METHODS
  University campus.
  
  
  RESULTS
  The SFST consists of the horizontal gaze nystagmus, walk-and-turn, and one-leg stand tests. Subjects were administered a baseline SFST and at 2 hours after the administration of either trazodone 100 mg (30 subjects) or acetaminophen 650 mg (15 subjects). At 2 hours post drug administration, there were no statistical differences in failure rates between the trazodone and acetaminophen groups (53.3% vs 20.0%, p=0.054). However, the trazodone group exhibited more impairment clues within the individual tests of the SFST than the acetaminophen group.
  
  
  CONCLUSIONS
  A one-time dose of trazodone 100 mg does not result in an increased SFST failure rate at 2 hours postdosing compared to acetaminophen 650 mg. However, the number of individual impairment clues detected is increased with trazodone. Trazodone 100 mg may cause cognitive driving impairment.
authors: Department of Pharmacy Practice, Touro University California College of Pharmacy, Vallejo, CA 94592, USA. eric.ip@tu.edu
authors: Eric J
authors: EJ
authors: Ip
authors: Quang V
authors: QV
authors: Bui
authors: Mitchell J
authors: MJ
authors: Barnett
authors: Amin
authors: A
authors: Kazani
authors: Roger
authors: R
authors: Wright
authors: Melissa J
authors: MJ
authors: Serino
authors: Paul J
authors: PJ
authors: Perry
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology; D000328:Adult; D003072:Cognition Disorders / Q000139:chemically induced* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D015813:Substance Abuse Detection / Q000379:methods*; D014196:Trazodone / Q000494:pharmacology*
chemical_list: D000082:Acetaminophen; D014196:Trazodone