title: Thyroid function and prevalence of anti-thyroperoxidase (TPO) and anti-thyroglobulin (Tg) antibodies in outpatients hospital setting in an area with sufficient iodine intake: influences of age and sex.
abstract: In order to examine the prevalence of thyroid disease in a hospital outpatient setting, in an area of sufficient iodine intake, serum levels of TSH, T4, T3, anti-Tg and anti-TPO antibodies were examined in 909 individuals with an age range of 12.4 to 88.5 years, participating in a checkup outpatient setting. The study was conducted in Henry Dynant Hospital located in the metropolitan area of Athens, Greece, during a 2 year period. Hormonal parameters were determined by chemiluminescence immunoassay. Overt thyrotoxicosis was found in 4.95% of the total population and subclinical thyrotoxicosis in 5.5%. Overt hypothyroidism was found in 1.43% and subclinical hypothyroidism in 4.51%. In male population, overt thyrotoxicosis was found in 4.4 % and subclinical thyrotoxicosis was also found in 4.4%. On the other hand, overt hypothyroidism was found in 1.4% and subclinical hypothyroidism was found in 3.7% in males. In female population, overt thyrotoxicosis was found in 5.2% whereas subclinical thyrotoxicosis was found in 6.0%. Overt hypothyroidism was found in 1.5% and subclinical hypothyroidism was found in 4,9% in females. Positive anti-TPO antibodies were detected more often (30.4%) than anti-Tg (15.4%) in the tested population. The positivity in both anti-TPO and anti-Tg antibodies was correlated with abnormally high TSH concentrations after the age of 50 years, especially in female population. In conclusion distinct profile of thyroid hormonal parameters was observed in inhabitants in the metropolitan area of Athens, with overt thyrotoxicosis strikingly overcome overt hypothyroidism while subclinical forms of each dysfunction also exhibit analogous results.
authors: Department of Endocrinology, Henry Dynant Hospital, Athens, Greece. ilegak@med.uoa.gr
authors: Ioannis
authors: I
authors: Legakis
authors: Mina
authors: M
authors: Manousaki
authors: Stela
authors: S
authors: Detsi
authors: Dimitra
authors: D
authors: Nikita
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D015551:Autoimmunity; D015415:Biomarkers / Q000097:blood; D002648:Child; D004032:Diet; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology; D007453:Iodide Peroxidase / Q000276:immunology*; D007455:Iodine / Q000008:administration & dosage*; D033862:Iron-Binding Proteins / Q000276:immunology*; D016014:Linear Models; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018673:Nutrition Policy; D010044:Outpatient Clinics, Hospital; D015995:Prevalence; D012737:Sex Factors; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D013971:Thyrotoxicosis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D033862:Iron-Binding Proteins; C006606:anti-thyroglobulin; D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; C056658:TPO protein, human; D007453:Iodide Peroxidase; D013974:Thyroxine