title: XRCC1 Polymorphisms and Pancreatic Cancer: A Meta-Analysis.
abstract: OBJECTIVE
  To assess the association between X-ray repair cross-complementating group 1 (XRCC1) polymorphisms and pancreatic cancer.
  
  
  METHODS
  We searched MEDLINE, Web of Science and HuGE Navigator at June 2010, and then quantitatively summarized associations of the XRCC1 polymorphisms with pancreatic cancer risk using meta-analysis.
  
  
  RESULTS
  Four studies with 1343 cases and 2302 controls were included. Our analysis found: at codon 194, the Trp allele did not decrease pancreatic cancer risk (Arg/Arg versus Trp/Trp: OR=0.97; 95% CI: 0.48-1.96; P=0.97; Arg/Arg versus Arg/Trp: OR=0.89; 95% CI: 0.70-1.13; P=0.55; Arg/Trp versus Trp/Trp: OR=1.06; 95% CI: 0.52-2.16; P=0.90); at codon 280, only a study showed a nonsignificant association between single nucleotide polymorphism with pancreatic cancer risk; at codon 399, the Gln allele also showed no signiﬁcant effect on pancreatic cancer compared to Arg allele (Arg/Arg versus Gln/Gln: OR=0.94; 95% CI: 0.74-1.18; Arg/Arg versus Arg/Gln: OR=0.97; 95% CI: 0.83-1.13; Arg/Gln versus Gln/Gln: OR=0.97; 95% CI: 0.77-1.22). The shape of the funnel plot and the Egger's test did not detect any publication bias.
  
  
  CONCLUSIONS
  There is no evidence that XRCC1 polymorphisms (Arg194Trp, Arg280His, and Arg399Gln) are associated with pancreatic cancer risk.
authors: Department of Gastroenterology, the Affiliated Jiangyin Hospital of Nantong University, Jiangyin 214400, China.
authors: Wei-Dong
authors: WD
authors: Shen
authors: Hong-Lin
authors: HL
authors: Chen
authors: Peng-Fei
authors: PF
authors: Liu
keywords: Gene polymorphism; Meta-analysis; Molecular epidemiology; Pancreatic cancer; X-ray repair cross-complementating group 1