title: IgG4-related disease in Singapore: a description of two cases and review of the literature.
abstract: We describe a 42-year-old man who presented with painless obstructive jaundice, organomegaly and lymphadenopathy. Biopsy of the ampulla of Vater revealed the presence of increased populations of plasma cells which stained positively for immunoglobulin G4. He was treated with prednisolone and demonstrated significant clinical improvement 1 month later. A further case is described and a review of the literature is also provided.
authors: Department of Rheumatology and Immunology, Singapore General Hospital, Singapore. warren.fong.w.s@sgh.com.sg
authors: Warren Weng Seng
authors: WW
authors: Fong
authors: Julian
authors: J
authors: Thumboo
authors: Rafay
authors: R
authors: Azhar
authors: Jon Kah Choun
authors: JK
authors: Yoong
mesh_terms: D000328:Adult; D014670:Ampulla of Vater / Q000378:metabolism / Q000473:pathology; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D003137:Common Bile Duct Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006942:Hypergammaglobulinemia / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood*; D041781:Jaundice, Obstructive / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008206:Lymphatic Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D012598:Sclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G; D011239:Prednisolone