title: Mesh-based method for measuring intracranial volume in patients with craniosynostosis.
abstract: OBJECTIVE
  Craniosynostosis may lead to reduced intracranial volume (ICV) and disturb normal brain growth and development. Thus, ICV is an important parameter with respect to the surgical outcome. Current methods for ICV determination from computed tomography (CT) images have drawbacks. The aim of this study was to investigate the performance of the novel mesh-based method (MBM) for ICV determination with craniosynostosis patients.
  
  
  METHODS
  Twenty-two patients operated on for scaphocephaly were included in this study. ICVs from preoperative, one-week postoperative, and one-year postoperative CT images were measured with MBM. The level of agreement with the manual segmentation method (MSM) was determined for the measurements of preoperative and one-year postoperative datasets. Repeatability was determined with re-measurements of six datasets. Measurement time was recorded for MBM.
  
  
  RESULTS
  Mean [Formula: see text] preoperative ICV values were 895.0 [Formula: see text] 153.1 [Formula: see text] and 896.4 [Formula: see text] 147.2 [Formula: see text] as measured with MBM and MSM, respectively. Corresponding one-year postoperative values were 1,238.3 [Formula: see text] 118.7 [Formula: see text] and 1,250.1 [Formula: see text] 117.5 [Formula: see text]. The MBM allowed ICV determination from one-week postoperative datasets. Measurement time with MBM was 4 CONCLUSIONS: MBM is an efficient method for determining the ICV of craniosynostosis patients, allowing the measurement of skulls with bony defects. The repeatability and short measurement time of MBM are attributable to the user interference and assessment of the measurement process.
authors: Department of Electronics, School of Electrical Engineering, Aalto University, Otakaari 7B, 02150 , Espoo, Finland, antti.ritvanen@aalto.fi.
authors: Antti G
authors: AG
authors: Ritvanen
authors: Marcelo Elias
authors: ME
authors: de Oliveira
authors: Mika P
authors: MP
authors: Koivikko
authors: Harri O
authors: HO
authors: Hallila
authors: Juha K
authors: JK
authors: Haaja
authors: Virve S
authors: VS
authors: Koljonen
authors: Junnu P
authors: JP
authors: Leikola
authors: Jyri J
authors: JJ
authors: Hukki
authors: Mervi M
authors: MM
authors: Paulasto-Kröckel
mesh_terms: D003398:Craniosynostoses / Q000175:diagnosis* / Q000601:surgery; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D061330:Multidetector Computed Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012886:Skull / Q000000981:diagnostic imaging*