title: Treatment for Staphylococcus aureus infection following open wedge high tibial osteotomy using antibiotic-impregnated calcium phosphate cement.
abstract: This report describes a case of Staphylococcus aureus infection following open wedge high tibial osteotomy, which was successfully treated with by implant removal and replacement with antibiotic-impregnated calcium phosphate cement along with external fixation. The infection occurred 7 months after primary surgery and was treated by implant removal, debridement, external fixation, and application of vancomycin impregnated calcium phosphate cement to fill the defect. Subsequently, the infection resolved completely, and the osteotomy healed with no correction loss. Compared with conventional bone cement, calcium phosphate cement might be an optimal material for certain cases of infection after open wedge high tibial osteotomy because of its higher antibiotic retention, biocompatibility, osteoconductivity, and compatibility with heatlabile antibiotics.
  
  
  METHODS
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authors: Department of Orthopaedic Surgery, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan, sk0105@yamaguchi-u.ac.jp.
authors: Kazushige
authors: K
authors: Seki
authors: Akihito
authors: A
authors: Sakka
authors: Atsunori
authors: A
authors: Tokushige
authors: Takashi
authors: T
authors: Imagama
authors: Masanori
authors: M
authors: Mutou
authors: Toshihiko
authors: T
authors: Taguchi
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001843:Bone Cements; D002130:Calcium Phosphates; D003646:Debridement; D020878:Device Removal; D005260:Female; D005592:Fracture Fixation; D006801:Humans; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000601:surgery*; D010027:Osteotomy / Q000009:adverse effects*; D013203:Staphylococcal Infections / Q000209:etiology / Q000628:therapy; D013211:Staphylococcus aureus; D013977:Tibia / Q000601:surgery*; D014640:Vancomycin / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D002130:Calcium Phosphates; D014640:Vancomycin; C020243:calcium phosphate