title: Kinetic analysis of bile salt passage across a dialysis membrane in the presence of cereal soluble dietary fibre polymers.
abstract: The kinetics of passage of a model bile salt and complete porcine bile across a dialysis membrane, in the presence and absence of two cereal-derived soluble dietary fibre polysaccharides, were studied as a model for passage across the unstirred water layer that lines the small intestine. A first-order kinetic analysis allowed rate coefficients to be derived which quantified the effectiveness of barley mixed linkage β-glucan and wheat arabinoxylan in retarding the transport of bile. For both, a model bile salt and complete porcine bile, rate coefficients decreased with both concentration and viscosity. A combination of viscosity and molecular interaction effects is suggested to control the effect of the two polysaccharides on the transport of bile.
authors: Centre for Nutrition and Food Sciences (CNAFS), Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Australia.
authors: Purnima
authors: P
authors: Gunness
authors: Bernadine M
authors: BM
authors: Flanagan
authors: Kinnari
authors: K
authors: Shelat
authors: Robert G
authors: RG
authors: Gilbert
authors: Michael J
authors: MJ
authors: Gidley
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000737:chemistry / Q000378:metabolism*; D001704:Biopolymers / Q000737:chemistry / Q000378:metabolism; D003956:Dialysis; D004043:Dietary Fiber / Q000032:analysis / Q000378:metabolism*; D001467:Hordeum / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D010539:Permeability; D013552:Swine; D014908:Triticum / Q000378:metabolism*; D014783:Viscosity; D014990:Xylans / Q000737:chemistry / Q000378:metabolism; D047071:beta-Glucans / Q000737:chemistry / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D001704:Biopolymers; D004043:Dietary Fiber; D014990:Xylans; D047071:beta-Glucans; C085118:arabinoxylan