title: Effect of velocity profile skewing on blood velocity and volume flow waveforms derived from maximum Doppler spectral velocity.
abstract: Given evidence that fully developed axisymmetric flow may be the exception rather than the rule, even in nominally straight arteries, maximum velocity (V(max)) can lie outside the Doppler sample volume (SV). The link between V(max) and derived quantities, such as volume flow (Q), may therefore be more complex than commonly thought. We performed idealized virtual Doppler ultrasound on data from image-based computational fluid dynamics (CFD) models of the normal human carotid artery and investigated how velocity profile skewing and choice of sample volume affected V(max) waveforms and derived Q variables, considering common assumptions about velocity profile shape (i.e., Poiseuille or Womersley). Severe velocity profile skewing caused substantial errors in V(max) waveforms when using a small, centered SV, although peak V(max) was reliably detected; errors with a long SV covering the vessel diameter were orientation dependent but lower overall. Cycle-averaged Q calculated from V(max) was typically within ±15%, although substantial skewing and use of a small SV caused 10%-25% underestimation. Peak Q derived from Womersley's theory was generally accurate to within ±10%. V(max) pulsatility and resistance indexes differed from Q-based values, although the Q-based resistance index could be predicted reliably. Skewing introduced significant error into V(max)-derived Q waveforms, particularly during mid-to-late systole. Our findings suggest that errors in the V(max) and Q waveforms related to velocity profile skewing and use of a small SV, or orientation-dependent errors for a long SV, could limit their use in wave analysis or for constructing characteristic or patient-specific flow boundary conditions for model studies.
authors: Biomedical Simulation Laboratory, Department of Mechanical and Industrial Engineering, University of Toronto, Canada.
authors: Jonathan P
authors: JP
authors: Mynard
authors: David A
authors: DA
authors: Steinman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology*; D001811:Blood Volume Determination / Q000379:methods*; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler / Q000379:methods*