title: Tumefactive demyelinating lesions: a clinicopathological correlative study.
abstract: Tumefactive demyelinating (TDL) lesions are focal zones of demyelination in the central nervous system and they often mimic the neuroimaging features of an intraxial neoplasm. In this report we describe the clinical, neuroimaging and neuropathological features of six cases of TDL. Only in two patients the neuroimaging features in MRI (magnetic resonance imaging) scans were suggestive of TDL while in the other four cases a diagnosis of glioma was suggested. In order to establish a confirmatory diagnosis neuronavigation/stereotactic biopsy was undertaken and the diagnosis of TDL was established in all six cases at histopathology. Two out of six patients did not respond to the conventional corticosteroid therapy and they were treated with plasma exchange. It is being concluded that neuronavigation biopsy, though provide only a small amount of tissue, and is extremely useful in making the diagnosis of TDL.
authors: Department of Pathology, Sree Chitra Tirunal Institute of Medical sciences and Technology, Trivandrum, Kerala, India.
authors: R
authors: R
authors: Neelima
authors: K
authors: K
authors: Krishnakumar
authors: M D
authors: MD
authors: Nair
authors: C
authors: C
authors: Kesavadas
authors: Divyata Rajendra
authors: DR
authors: Hingwala
authors: V V
authors: VV
authors: Radhakrishnan
authors: Sruthi S
authors: SS
authors: Nair
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods; D002648:Child; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods; D012189:Retrospective Studies