title: Serum levels of adrenomedullin and inflammatory cytokines in women with term idiopathic intrauterine growth restriction.
abstract: This study aimed to determine the concentrations of adrenomedullin (AM), tumour necrosis factor (TNF)-α and interleukin (IL)-6 in maternal circulation of full-term idiopathic intrauterine growth restriction (IUGR) in relation to appropriate-for-gestational-age (AGA) and the possible correlation of AM to these cytokines. A case-control study included 50 idiopathic IUGR mothers and 25 AGA, who were evaluated regarding their serum levels of AM, TNF-α and IL-6. We found that women with idiopathic IUGR have significantly higher serum levels of AM, TNF-α and IL-6 (p = 0.008; 0.016; 0.029, respectively) and the level of AM was significantly correlated to serum level of TNF-α (r = 0.417, p = 0.003) but not significantly correlated to IL-6 compared with the AGA group. In conclusion, the significant increase of AM, TNF-α and IL-6 in the idiopathic IUGR group might contribute to the uteroplacental haemodynamic alterations and can serve as a useful biochemical marker. Significant correlation between AM and TNF-α could hypothesise the existence of a complex interaction between AM and this inflammatory cytokine.
authors: Department of Obstetrics and Gynecology Taibah University, Saudi Arabia. amr.fyomy@yahoo.com
authors: A K
authors: AK
authors: Elfayomy
authors: F A
authors: FA
authors: Habib
authors: S M
authors: SM
authors: Almasry
authors: M D
authors: MD
authors: Safwat
authors: M A
authors: MA
authors: Eldomiaty
mesh_terms: D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000000981:diagnostic imaging; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D011247:Pregnancy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D016216:Ultrasonography, Prenatal
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D053607:Adrenomedullin