title: Aberrant expression of E-cadherin and integrin β-1 in trophoblasts is associated with malignant gestational trophoblastic diseases.
abstract: OBJECTIVE
  To investigate the association between malignant gestational trophoblastic diseases and aberrant local expression of E-cadherin and integrin β-1 in the context of identifying a method to predict and diagnose malignant gestational trophoblastic diseases at an early stage.
  
  
  METHODS
  We used immunohistochemistry to assess E-cadherin and integrin β-1 expression profiles in normal chorionic villus, hydatidiform mole, and invasive mole.
  
  
  RESULTS
  E-cadherin expression gradually decreased from normal tissue to malignant tissue. Staining for E-cadherin was positive in 90% of normal trophoblastic villus in early pregnancy, 80% in benign hydatidiform mole, and 50% in invasive mole. Notably, invasive mole had significantly lower E-cadherin expression than benign mole (P < 0.05). However, there was no significant difference in staining between benign and malignant moles (15% vs 10%, P > 0.05). Integrin β-1 expression was identical in benign hydatidiform mole and malignant mole (90% and 90%), but this value was significantly higher than that in normal trophoblastic villus (40%, both P < 0.05). Moreover, malignant mole staining was significantly higher than in the benign mole (30% vs 15%, P < 0.05).
  
  
  CONCLUSIONS
  Aberrant expression of E-cadherin and integrin β-1 is closely related to malignant transformation and hydatidiform mole development. Changes in the expression of E-cadherin and integrin β-1 are informative and may improve the early diagnosis of malignant/invasive moles.
authors: Department of Obstetrics and Gynecology, Gongli Hospital, Pudong New Area, Shanghai, China.
authors: Huimin
authors: H
authors: Shu
authors: Hua
authors: H
authors: Chen
authors: Binlie
authors: B
authors: Yang
authors: Zhuolin
authors: Z
authors: Chang
authors: Miao
authors: M
authors: Xiong
authors: Weixiang
authors: W
authors: Chen
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D015820:Cadherins / Q000096:biosynthesis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D006801:Humans; D019012:Integrin beta1 / Q000096:biosynthesis / Q000235:genetics*; D008875:Middle Aged; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D019012:Integrin beta1