title: Zoom Zoom: racing CARs for multiple myeloma.
abstract: Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expand the possible indications for chimeric-antigen receptor (CAR)-T cells. B-cell maturation antigen (BCMA) is expressed only on mature B cells and plasma cells and promotes their survival. BCMA is a promising target for CAR-T cells in multiple myeloma.
authors: Translational Research Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. mausm@uphs.upenn.edu
authors: Marcela V
authors: MV
authors: Maus
authors: Carl H
authors: CH
authors: June
mesh_terms: D000818:Animals; D053301:B-Cell Maturation Antigen / Q000276:immunology*; D006801:Humans; D009101:Multiple Myeloma / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D053301:B-Cell Maturation Antigen; D011948:Receptors, Antigen, T-Cell