title: Sinonasal undifferentiated carcinoma (SNUC): morphoproteomic-guided treatment paradigm with clinical efficacy.
abstract: Sinonasal undifferentiated carcinoma (SNUC) is a rare and highly malignant tumor that occurs in the nasal cavity and/or paranasal sinuses. Prognosis is poor despite multimodality treatment. Currently, there is no optimal standard of treatment, partially due to a lack of research defining the biology of such tumors. This report discusses two SNUC cases where patients received a novel chemotherapeutic approach using cisplatin, etoposide, Adriamycin (doxorubicin), metformin, and adjuvant melatonin therapies based on morphoproteomic-guidance, followed by consolidation with chemoradiation therapy. This resulted in excellent and objective tomographic and magnetic resonance imaging and clinical responses including complete responses in the induction phase utilizing morphoproteomic-guided therapies. Later, endoscopic excision of the tumor bed failed to reveal any residual tumor. Morphoproteomics helped to define the biology of these SNUC tumors and provided targets for the agents employed, creating a new treatment paradigm for such tumors. This treatment regimen poses a new effective regimen to treat SNUC.
authors: Division of Oncology, Department of Internal Medicine, University of Texas Medical School at Houston and Memorial Hermann Cancer Center, Houston, TX 77030, USA.
authors: Maria
authors: M
authors: Ansari
authors: Shan
authors: S
authors: Guo
authors: Samer
authors: S
authors: Fakhri
authors: Martin J
authors: MJ
authors: Citardi
authors: Angel
authors: A
authors: Blanco
authors: Maria
authors: M
authors: Patino
authors: Jamie
authors: J
authors: Buryanek
authors: Robert
authors: R
authors: Amato
authors: Ron
authors: R
authors: Karni
authors: Robert E
authors: RE
authors: Brown
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D060828:Induction Chemotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D009296:Nasal Cavity / Q000473:pathology; D040901:Proteomics; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult