title: CYP19 gene variants affect the assisted reproduction outcome of women with polycystic ovary syndrome.
abstract: OBJECTIVE
  Cytochrome P450 aromatase catalyzes the irreversible transformation of androgens into estrogens. The association of CYP19(TTTA)n polymorphism with the hormonal profile and the assisted reproduction outcome of women with polycystic ovary syndrome (PCOS) was explored.
  
  
  METHODS
  One hundred and thirty-two women with PCOS and 200 with male-factor infertility, as controls, participated in the current study. The CYP19(TTTA)n polymorphism was genotyped, while the hormonal profile was determined at the third day of the menstrual cycle. During oocyte retrieval, the follicular size, the follicle and oocyte numbers were recorded.
  
  
  RESULTS
  Genotype analysis revealed 6 CYP19(TTTA)n alleles with 7-12 repeats. In PCOS women, the CYP19(TTTA)7 allele presence was associated with lower serum E2 levels at the third day of the menstrual cycle (p < 0.009), lower large follicle (p < 0.02) and total oocyte numbers (p = 0.006), but with significantly higher pregnancy rates after assisted reproduction (p < 0.004).
  
  
  CONCLUSIONS
  Potential associations of the CYP19(TTTA)7 allele with ovarian response to standard gonadotrophin stimulation and with assisted reproduction outcome were found in PCOS women, probably due to androgen/estrogen ratio alterations.
authors: Department of Obstetrics and Gynecology, Medical School, Ioannina University, Ioannina, Greece.
authors: Leandros
authors: L
authors: Lazaros
authors: Nectaria
authors: N
authors: Xita
authors: Elissavet
authors: E
authors: Hatzi
authors: Atsushi
authors: A
authors: Takenaka
authors: Apostolos
authors: A
authors: Kaponis
authors: Georgios
authors: G
authors: Makrydimas
authors: Nikolaos
authors: N
authors: Sofikitis
authors: Theodoros
authors: T
authors: Stefos
authors: Konstantinos
authors: K
authors: Zikopoulos
authors: Ioannis
authors: I
authors: Georgiou
mesh_terms: D000328:Adult; D000483:Alleles; D001141:Aromatase / Q000235:genetics*; D005260:Female; D005307:Fertilization in Vitro; D005838:Genotype; D006062:Gonadotropins / Q000008:administration & dosage; D006801:Humans; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D018873:Pregnancy Rate; D055815:Young Adult
chemical_list: D006062:Gonadotropins; D001141:Aromatase