title: KIR gene content in amerindians indicates influence of demographic factors.
abstract: Although the KIR gene content polymorphism has been studied worldwide, only a few isolated or Amerindian populations have been analyzed. This extremely diverse gene family codifies receptors that are expressed mainly in NK cells and bind HLA class I molecules. KIR-HLA combinations have been associated to several diseases and population studies are important to comprehend their evolution and their role in immunity. Here we analyzed, by PCR-SSP (specific sequencing priming), 327 individuals from four isolated groups of two of the most important Brazilian Amerindian populations: Kaingang and Guarani. The pattern of KIR diversity among these and other ten Amerindian populations disclosed a wide range of variation for both KIR haplotypes and gene frequencies, indicating that demographic factors, such as bottleneck and founder effects, were the most important evolutionary factors in shaping the KIR polymorphism in these populations.
authors: Laboratório de Genética Molecular Humana, Universidade Federal do Paraná, Curitiba, Brazil.
authors: Danillo Gardenal
authors: DG
authors: Augusto
authors: Bruno Zagonel
authors: BZ
authors: Piovezan
authors: Luiza Tamie
authors: LT
authors: Tsuneto
authors: Sidia Maria
authors: SM
authors: Callegari-Jacques
authors: Maria Luiza
authors: ML
authors: Petzl-Erler
mesh_terms: D001938:Brazil; D003710:Demography; D005787:Gene Frequency / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D007199:Indians, South American / Q000235:genetics; D015810:Linkage Disequilibrium / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D054340:Receptors, KIR / Q000235:genetics*
chemical_list: D006680:HLA Antigens; D054340:Receptors, KIR