title: Epstein-Barr virus associated smooth muscle tumors in post transplant pediatric patients two cases of rare locations, and review of the literature.
abstract: Epstein-Barr virus (EBV) may present few or no symptoms in immunocompetent individuals; however, in immunocompromised patients as in the case of AIDS and post-transplant patients, the virus occasionally stimulates neoplastic transformations. Epstein-Barr virus may play a role in the development of smooth muscle tumors (SMT). In the case of Epstein-Barr associated smooth muscle tumors (EBV+SMT), the virus is thought to be the leading factor to the tumorigenic pathway. We report two pediatric patients (6 and 13 years old) who underwent liver transplantation and developed EBV+SMT in the colon and orbit. These two cases represent rare locations for this kind of lesion.
authors: Children's Healthcare of Atlanta, Pathology Laboratory, Atlanta, Georgia 30322, USA.
authors: Nancy
authors: N
authors: Elawabdeh
authors: Brent M
authors: BM
authors: Cone
authors: Carlos R
authors: CR
authors: Abramowsky
authors: David M
authors: DM
authors: Wrubel
authors: Hans
authors: H
authors: Grossniklaus
authors: Joseph
authors: J
authors: Walrath
authors: Maaman Z
authors: MZ
authors: Bashir
authors: Bahig M
authors: BM
authors: Shehata
mesh_terms: D000293:Adolescent; D002648:Child; D003110:Colonic Neoplasms / Q000473:pathology* / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007889:Leiomyoma / Q000473:pathology* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D009918:Orbital Neoplasms / Q000473:pathology* / Q000821:virology; D011183:Postoperative Complications