title: Comparison of age-stratified seroprevalence of antibodies against norovirus GII in India and the United Kingdom.
abstract: Noroviruses are a common cause of gastroenteritis worldwide, but outbreaks appear to be more common in industrialized countries than in developing countries, possibly reflecting differences in exposure and immunity. In this study, age-stratified sera from India and UK populations were analysed for the presence of norovirus-genogroup II specific IgG by a time resolved immunofluorescence assay and relative levels of antibodies in the two populations were compared. Antibody levels were higher among all age groups in India than in UK and increased with age in India, whereas in the UK, levels of antibody decreased in adulthood. These results indicate different patterns of exposure to noroviruses in the two countries.
authors: Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India.
authors: Vipin Kumar
authors: VK
authors: Menon
authors: Santosh
authors: S
authors: George
authors: Farah
authors: F
authors: Aladin
authors: Sameena
authors: S
authors: Nawaz
authors: Rajiv
authors: R
authors: Sarkar
authors: Ben
authors: B
authors: Lopman
authors: James J
authors: JJ
authors: Gray
authors: Miren Iturriza
authors: MI
authors: Gomara
authors: Gagandeep
authors: G
authors: Kang
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000914:Antibodies, Viral / Q000276:immunology*; D017250:Caliciviridae Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005063:Europium; D005759:Gastroenteritis / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D029322:Norovirus / Q000276:immunology*; D016036:Seroepidemiologic Studies; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D005063:Europium