title: Persistent neurological damage associated with spontaneous recurrent seizures and atypical aggressive behavior of domoic acid epileptic disease.
abstract: The harmful alga Pseudo-nitzschia sp. is the cause of human amnesic shellfish poisoning and the stranding of thousands of sea lions with seizures as a hallmark symptom. A human case study and epidemiological report of hundreds of stranded sea lions found individuals presenting months after recovery with a neurological disease similar to temporal lobe epilepsy. A rat model developed to establish and better predict how epileptic disease results from domoic acid poisoning demonstrated that a single episode of status epilepticus (SE), after a latent period, leads to a progressive state of spontaneous recurrent seizure (SRS) and expression of atypical aggressive behaviors. Structural damage associated with domoic acid-induced SE is prominent in olfactory pathways. Here, we examine structural damage in seven rats that progressed to epileptic disease. Diseased animals show progressive neuronal loss in the piriform cortex and degeneration of terminal fields in these layers and the posteromedial cortical amygdaloid nucleus. Animals that display aggressive behavior had additional neuronal damage to the anterior olfactory cortex. This study provides insight into the structural basis for the progression of domoic acid epileptic disease and relates to the California sea lion, where poisoned animals progress to a disease characterized by SRS and aggressive behaviors.
authors: Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, NOAA - National Ocean Service, Charleston, South Carolina 29412, USA.
authors: Jessica A
authors: JA
authors: Tiedeken
authors: John S
authors: JS
authors: Ramsdell
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D002452:Cell Count; D004195:Disease Models, Animal; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000506:poisoning; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012008:Recurrence; D012640:Seizures / Q000139:chemically induced / Q000473:pathology / Q000523:psychology*; D013226:Status Epilepticus / Q000139:chemically induced / Q000473:pathology / Q000523:psychology*
chemical_list: C012301:domoic acid; D007608:Kainic Acid