title: Regeneration of condyle with a functional appliance.
abstract: Condylar regeneration with the use of functional appliances after condylectomy has been validated. However, the process during treatment remains unclear. In this study, we evaluated the condylar regeneration process and then examined mandibular growth and masticatory muscle activity after regeneration in growing rats. Seventy-five male Wistar rats aged 4 weeks were equally divided into 3 groups: unilateral condylectomy group, unilateral condylectomy + appliance group, or control group. The use of a functional appliance following condylectomy promoted mandibular growth and regeneration of the condyle 1 week after condylectomy. Condyle regeneration showing normal morphology was finally achieved 8 weeks after condylectomy. Asymmetrical masticatory muscle activity was observed after condylectomy. However, the use of a functional appliance produced symmetrical masticatory muscle activity. These results indicate a favorable regeneration process in the condylectomized area due to the use of a functional appliance. In addition, due to condylar regeneration, symmetrical masticatory muscle activity was achieved.
authors: Department of Orthodontics and Craniofacial Developmental Biology, Applied Life Sciences, Hiroshima University Institute of Biomedical & Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. seven@ hiroshima-u.ac.jp
authors: T
authors: T
authors: Fujita
authors: H
authors: H
authors: Hayashi
authors: M
authors: M
authors: Shirakura
authors: Y
authors: Y
authors: Tsuka
authors: E
authors: E
authors: Fujii
authors: T
authors: T
authors: Kawata
authors: M
authors: M
authors: Kaku
authors: J
authors: J
authors: Ohtani
authors: M
authors: M
authors: Motokawa
authors: K
authors: K
authors: Tanne
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D008137:Longitudinal Studies; D008297:Male; D019186:Mandibular Advancement / Q000295:instrumentation*; D008335:Mandibular Condyle / Q000254:growth & development*; D016382:Orthodontic Appliance Design; D010012:Osteogenesis / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome