title: Within-day and between-day repeatability of measurements with an electronic nose in patients with COPD.
abstract: Electronic noses (e-noses), artificial sensor systems generally consisting of chemical sensor arrays for the detection of volatile compound profiles, have potential applications in respiratory medicine. We assessed within-day and between-day repeatability of an e-nose made from 32 sensors in patients with stable chronic obstructive pulmonary disease (COPD). We also compared between-day repeatability of an e-nose, fraction of exhaled nitric oxide (FENO) and pulmonary function testing. Within-day and between-day repeatability for the e-nose was assessed in two breath samples collected 30 min and seven days apart, respectively. Repeatability was expressed as an intraclass correlation coefficient (ICC). All sensors had ICC above 0.5, a value that is considered acceptable for repeatability. Regarding within-day repeatability, ICC ranged from 0.75 to 0.84 (mean = 0.80 ± 0.004). Sensors 6 and 19 were the most reproducible sensors (both, ICC = 0.84). Regarding between-day repeatability, ICC ranged from 0.57 to 0.76 (mean = 0.68 ± 0.01). Sensor 19 was the most reproducible sensor (ICC = 0.76). Within-day e-nose repeatability was greater than between-day repeatability (P < 0.0001). Between-day repeatability of FENO (ICC = 0.91) and spirometry (ICC range = 0.94-0.98) was greater than that of e-nose (mean ICC = 0.68). In patients with stable COPD, the e-nose used in this study has acceptable within-day and between-day repeatability which varies between different sensors.
authors: Department of Applied Electronics, Faculty of Engineering, University of Roma 3, Rome, Italy.
authors: Maria
authors: M
authors: Bofan
authors: Nadia
authors: N
authors: Mores
authors: Marco
authors: M
authors: Baron
authors: Malgorzata
authors: M
authors: Dabrowska
authors: Salvatore
authors: S
authors: Valente
authors: Maurizio
authors: M
authors: Schmid
authors: Andrea
authors: A
authors: Trové
authors: Silvia
authors: S
authors: Conforto
authors: Gina
authors: G
authors: Zini
authors: Paola
authors: P
authors: Cattani
authors: Leonello
authors: L
authors: Fuso
authors: Antonella
authors: A
authors: Mautone
authors: Chiara
authors: C
authors: Mondino
authors: Gabriella
authors: G
authors: Pagliari
authors: Tommaso
authors: T
authors: D'Alessio
authors: Paolo
authors: P
authors: Montuschi
mesh_terms: D000368:Aged; D001944:Breath Tests / Q000295:instrumentation*; D045853:Exhalation; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism*; D015203:Reproducibility of Results; D013147:Spirometry
chemical_list: D009569:Nitric Oxide