title: The effects of hyperbaric oxygen therapy on experimental colon anastomosis after preoperative chemoradiotherapy.
abstract: The aim of the present study was to investigate the effect of hyperbaric oxygen therapy (HBOT) on colon anastomosis after chemoradiotherapy (CRT). Sixty female Wistar-Albino rats were divided into 5 groups and underwent left colon resection and end-to-end anastomosis. CRT simulation was performed on 2 sham groups before the anastomosis, and 1 of these groups was administered additional postoperative HBOT. Two groups were administered CRT before the anastomosis, and 1 of them received additional postoperative HBOT. On postoperative day 5, all groups underwent relaparotomy; burst pressure was measured and samples were obtained for histopathologic and biochemical analysis. There was a significant weight loss in the CRT groups and postoperative HBOT had an improving effect. Significantly decreased burst pressure values increased up to the levels of the controls after HBOT. Hydroxyproline levels were elevated in all groups compared to the control group. Hydroxyproline levels decreased with HBOT after CRT. No significant difference was observed between the groups regarding fibrosis formation at the anastomosis site. However, regression was observed in fibrosis in the group receiving HBOT after CRT. Preoperative CRT affected anastomosis and wound healing unfavorably. These unfavorable effects were alleviated by postoperative HBOT. HBOT improved the mechanical and biochemical parameters of colon anastomosis in rats.
authors: 1 Department of Surgery.
authors: Ramazan
authors: R
authors: Yildiz
authors: Mehmet Fatih
authors: MF
authors: Can
authors: Gokhan
authors: G
authors: Yagci
authors: Taner
authors: T
authors: Ozgurtas
authors: Metin
authors: M
authors: Guden
authors: Mehmet
authors: M
authors: Gamsizkan
authors: Erkan
authors: E
authors: Ozturk
authors: Sadettin
authors: S
authors: Cetiner
mesh_terms: D000714:Anastomosis, Surgical; D057868:Anastomotic Leak / Q000517:prevention & control*; D000818:Animals; D059186:Chemoradiotherapy, Adjuvant / Q000009:adverse effects*; D003082:Colectomy; D003106:Colon / Q000473:pathology / Q000601:surgery*; D005260:Female; D006931:Hyperbaric Oxygenation; D020360:Neoadjuvant Therapy / Q000009:adverse effects*; D011182:Postoperative Care / Q000379:methods*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects / Q000528:radiation effects