title: The emerging role of acetylation in the regulation of autophagy.
abstract: Autophagy is an evolutionarily conserved catabolic process through which different components of the cells are sequestered into double-membrane cytosolic vesicles called autophagosomes, and fated to degradation through fusion with lysosomes. Autophagy plays a major function in many physiological processes including response to different stress factors, energy homeostasis, elimination of cellular organelles and tissue remodeling during development. Consequently, autophagy is strictly controlled and post-translational modifications such as phosphorylation and ubiquitination have long been associated with autophagy regulation. In contrast, the importance of acetylation in autophagy control has only emerged in the last few years. In this review, we summarize how previously identified histone acetylases and deacetylases modify key autophagic effector proteins, and discuss how this has an impact on physiological and pathological cellular processes.
authors: Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary. abanreti@gmail.com
authors: Agnes
authors: A
authors: Bánréti
authors: Miklós
authors: M
authors: Sass
authors: Yacine
authors: Y
authors: Graba
mesh_terms: D000107:Acetylation; D000818:Animals; D001343:Autophagy; D003599:Cytoskeleton / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000378:metabolism; D051548:Histone Acetyltransferases / Q000378:metabolism; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans
chemical_list: D051858:Forkhead Transcription Factors; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases
keywords: ATG genes; FOXO; Huntington disease; acetylation; autophagy; deacetylation; lysine; post-translational modification; protein aggregates