title: Non-light-chain immunoglobulin amyloidosis: time to expand or refine the spectrum to include light+heavy chain amyloidosis?
abstract: Among the various systemic amyloidoses, deposits derived from the immunoglobulin light chain (AL) account for 85% of cases. In this issue, Nasr et al. report 16 cases of renal heavy and light+heavy chain amyloidosis and compare them with renal light chain amyloidosis. While additional studies are needed to shed light on the heavy and light+heavy chain amyloidoses, several observations by the authors suggest important practical implications, including differences in clinical picture, prognosis and pathologic diagnosis.
authors: Department of Pathology, Loyola University Medical Center, Building 110, Room 2242, 2160 S. First Avenue, Maywood, Illinois 60153, USA. mpicken@lumc.edu
authors: Maria M
authors: MM
authors: Picken
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis*; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007674:Kidney Diseases / Q000175:diagnosis*; D008297:Male
chemical_list: D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains