title: Tissue ingrowth into perforated polymethylmethacrylate orbital implants: an experimental study.
abstract: OBJECTIVE
  To evaluate the clinical response and fibrovascular ingrowth into perforated acrylic orbital implants in a rabbit model.
  
  
  METHODS
  Perforated implants were manufactured by drilling channels interconnected at the center in conventional 12- to 13-mm acrylic spheres. The implants were placed in 16 eviscerated eyes with posterior sclerotomy of 16 New Zealand white rabbits. Clinical evaluation was performed daily for the first 14 days after surgery and at 7-day intervals until the end of the study (180 days). Histopathologic analysis was performed at 14, 45, 90, and 180 days after implantation. Hematoxylin-eosin and picrosirius red staining was used to assess the inflammatory reaction and collagen formation.
  
  
  RESULTS
  There were no signs of infection, implant exposure, or extrusion in any animal during the study. Tissue ingrowth in the implant center was already detected by 14 days. At the end of the study, there was a dense collagen ingrowth with just a few inflammatory cells inside the implant. No multinucleated giant cells were found in any implant.
  
  
  CONCLUSIONS
  Similar to porous implants, perforated acrylic implants permit fibrovascular ingrowth from surrounding orbital tissues.
authors: Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas-Campus, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
authors: Denise
authors: D
authors: Miyashita
authors: Fernando
authors: F
authors: Chahud
authors: Gyl Eanes Barros
authors: GE
authors: da Silva
authors: Verônica Batista
authors: VB
authors: de Albuquerque
authors: Denny Marcos
authors: DM
authors: Garcia
authors: Antonio Augusto
authors: AA
authors: Velasco e Cruz
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D049109:Cell Proliferation; D003094:Collagen / Q000378:metabolism; D003239:Connective Tissue Cells / Q000166:cytology* / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009504:Neutrophils / Q000166:cytology; D017233:Orbit Evisceration; D020273:Orbital Implants; D019904:Polymethyl Methacrylate; D016062:Porosity; D019919:Prosthesis Implantation; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D003094:Collagen; D019904:Polymethyl Methacrylate