title: 21st century natural product research and drug development and traditional medicines.
abstract: Natural products and related structures are essential sources of new pharmaceuticals, because of the immense variety of functionally relevant secondary metabolites of microbial and plant species. Furthermore, the development of powerful analytical tools based upon genomics, proteomics, metabolomics, bioinformatics and other 21st century technologies are greatly expediting identification and characterization of these natural products. Here we discuss the synergistic and reciprocal benefits of linking these 'omics technologies with robust ethnobotanical and ethnomedical studies of traditional medicines, to provide critically needed improved medicines and treatments that are inexpensive, accessible, safe and reliable. However, careless application of modern technologies can challenge traditional knowledge and biodiversity that are the foundation of traditional medicines. To address such challenges while fulfilling the need for improved (and new) medicines, we encourage the development of Regional Centres of 'omics Technologies functionally linked with Regional Centres of Genetic Resources, especially in regions of the world where use of traditional medicines is prevalent and essential for health.
authors: Genetics Area Program, University of Missouri, Columbia, MO 65211, USA.
authors: Linh T
authors: LT
authors: Ngo
authors: Joseph I
authors: JI
authors: Okogun
authors: William R
authors: WR
authors: Folk
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D055808:Drug Discovery; D049674:History, 21st Century; D008519:Medicine, Traditional; D015394:Molecular Structure; D028321:Plant Preparations / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D000995:Antitubercular Agents; D001688:Biological Products; D028321:Plant Preparations