title: Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development.
abstract: Cancer is one of the leading causes of death worldwide. Commonly used cancer treatments, including chemotherapy and radiation therapy, often have side effects and a complete cure is sometimes impossible. Therefore, prevention, suppression, and/or delaying the onset of the disease are important. The onset of gastroenterological cancers is closely associated with an individual's lifestyle. Thus, changing lifestyle, specifically the consumption of fruits and vegetables, can help to protect against the development of gastroenterological cancers. In particular, naturally occurring bioactive compounds, including curcumin, resveratrol, isothiocyanates, (-)-epigallocatechin gallate and sulforaphane, are regarded as promising chemopreventive agents. Hence, regular consumption of these natural bioactive compounds found in foods can contribute to prevention, suppression, and/or delay of gastroenterological cancer development. In this review, we will summarize natural phytochemicals possessing potential antioxidant and/or anti-inflammatory and anti-carcinogenic activities, which are exerted by regulating or targeting specific molecules against gastroenterological cancers, including esophageal, gastric and colon cancers.
authors: Center for Food and Bioconvergence, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea.
authors: Min-Yu
authors: MY
authors: Chung
authors: Tae Gyu
authors: TG
authors: Lim
authors: Ki Won
authors: KW
authors: Lee
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D004032:Diet; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D064209:Phytochemicals / Q000008:administration & dosage*; D040242:Risk Reduction Behavior; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D016588:Anticarcinogenic Agents; D064209:Phytochemicals
keywords: (-)-Epigallocatechin gallate; Curcumin; Gastroenterological cancers; Isothiocyanates; Molecular target; Resveratrol; Sulforaphane