title: Mitochondrial dysfunction and oxidative stress in insulin resistance.
abstract: Evidence is mounting of the involvement of mitochondrial dysfunction in insulin resistance, diabetes and associated complications. This review aims to provide an overview of the effects of insulin resistance on mitochondrial function in several tissues. We consider the pathogenesis of insulin resistance from a mitochondrial perspective and contemplate potential beneficial effects of strategies aimed at modulating mitochondrial function in insulin resistance, including insulin and insulin-sensitizing drugs, antioxidants, and selectively targeting antioxidants to mitochondria.
authors: University Hospital Doctor Peset, Endocrinology Service, Avda Gaspar Aguilar 90, 46017, Valencia, Spain.
authors: Milagros
authors: M
authors: Rocha
authors: Susana
authors: S
authors: Rovira-Llopis
authors: Celia
authors: C
authors: Bañuls
authors: Lorena
authors: L
authors: Bellod
authors: Rosa
authors: R
authors: Falcon
authors: Raquel
authors: R
authors: Castello
authors: Carlos
authors: C
authors: Morillas
authors: Jose R
authors: JR
authors: Herance
authors: Antonio
authors: A
authors: Hernandez-Mijares
authors: Victor M
authors: VM
authors: Victor
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D048909:Diabetes Complications / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000503:physiopathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism; D007333:Insulin Resistance; D008928:Mitochondria / Q000473:pathology*; D058990:Molecular Targeted Therapy; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D007004:Hypoglycemic Agents; D007328:Insulin