title: Fanconi anemia pathway--the way of DNA interstrand cross-link repair.
abstract: The study of rare genetic diseases usually inspires the research of cancer biology. Fanconi anemia (FA), is a rare cancer susceptibility syndrome with an incidence of only 1 per 350,000 births. FA is an autosomal recessive disease with three main features: chromosome instability, hypersensitivity to DNA cross-linking agents such as mitomycin C (MMC), cisplatin and so on, and susceptible to a number of cancer types, mainly leukemia and squamous cell carcinomas of the head and neck or gynecologic system. DNA crosslinking agents may led to DNA cross-linking lesion, and Fanconi anemia pathway plays a key role in repairing its cross-linking. However, FA pathway is closely linked with carcinogenesis and tumor drug resistance. This paper mainly focuses on the FA pathway and its progress in cancer research.
authors: Department of Hematology, Central South University Third Xiangya Hospital, Changsha, China.
authors: C J
authors: CJ
authors: Yao
authors: W
authors: W
authors: Du
authors: Q
authors: Q
authors: Zhang
authors: F
authors: F
authors: Zhang
authors: F
authors: F
authors: Zeng
authors: F P
authors: FP
authors: Chen
mesh_terms: D003432:Cross-Linking Reagents; D004247:DNA / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D005199:Fanconi Anemia / Q000235:genetics*; D051856:Fanconi Anemia Complementation Group Proteins / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology; D014451:Ubiquinone / Q000378:metabolism
chemical_list: D003432:Cross-Linking Reagents; D051856:Fanconi Anemia Complementation Group Proteins; D014451:Ubiquinone; D004247:DNA