title: Biotransformation of 14-deoxy-14-methylenetriptolide into a novel hydroxylation product by Neurospora crassa.
abstract: The biotransformation of 14-deoxy-14-methylenetriptolide by Neurospora crassa CGMCC AS 3.1604 to produce a new hydroxylation derivative was studied. The structure of this novel compound was determined using spectral data. This biotransformation using whole cells conditioned for 4 days transformed approximately 65% (mol ratio) of the substrate into the compound (5R)-5-hydroxy-14-deoxy-14-methylenetriptolide.
authors: The State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Institute of Pharmaceutical Industry, 1320 West Beijing Rd, Shanghai 200040, China.
authors: Zhouzhou
authors: Z
authors: Chen
authors: Ji'an
authors: J
authors: Li
authors: Huimin
authors: H
authors: Lin
authors: Lei
authors: L
authors: Shao
authors: Jihong
authors: J
authors: Qin
authors: Xing
authors: X
authors: Fan
authors: Xiaojing
authors: X
authors: Dong
authors: Daijie
authors: D
authors: Chen
mesh_terms: D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D004852:Epoxy Compounds / Q000737:chemistry / Q000378:metabolism*; D006900:Hydroxylation; D009492:Neurospora crassa / Q000378:metabolism*
chemical_list: C586436:(5R)-5-hydroxy-14-deoxy-14-methylenetriptolide; C586435:14-deoxy-14-methylenetriptolide; D004224:Diterpenes; D004852:Epoxy Compounds