title: The use of CEUS in the diagnosis of retinal/choroidal detachment and associated intraocular masses - preliminary investigation in patients with equivocal findings at conventional ultrasound.
abstract: OBJECTIVE
  To investigate whether contrast-enhanced ultrasound (CEUS) may help to diagnose retinal/choroidal detachment and may help to differentiate intraocular lumps in cases with equivocal features on conventional grayscale and Doppler modes.
  
  
  METHODS
  The institutional review board approved this retrospective study. The need for informed consent was waived. A computerized data search was performed in the database of our institution for patients with vitreous hemorrhage who underwent CEUS of the eye to assess retinal/choroidal detachment and/or associated masses. This process yielded a total of 31 patients (18 men, 13 women, age range: 39 - 88 years) in whom CEUS was performed because the findings on conventional grayscale and Doppler modes were equivocal. CEUS was performed using low acoustic power contrast-specific modes. A 2.4 - 4.8  mL bolus of SonoVue was injected, followed by a saline flush. All examinations were digitally recorded for retrospective analysis. Confirmation of CEUS findings was obtained at surgery (n = 20) or with binocular indirect fundoscopy performed after clearance of the ocular media (n = 11). Two readers with different levels of ultrasound experience independently reviewed the imaging features. A five-degree scale ranging from definitely absent (score 1) to definitely present (score 5) was used to assess the presence or absence of retinal/choroidal detachment on conventional ultrasound modes alone and with the addition of CEUS. ROC curve analysis was performed to assess the diagnostic accuracy of both methods. The inter-reader agreement was also evaluated. In patients with associated intraocular lumps, conventional Doppler modes and CEUS were used to differentiate non-tumor masses from tumor masses.
  
  
  RESULTS
  According to the reference standard, 13 patients had retinal detachment, 4 had choroidal detachment, and 3 had both retinal and choroidal detachment. There were 8 associated intraocular lumps (4 subretinal hemorrhages, 3 malignant melanomas, 1 metastasis). The inter-reader agreement was good (K = 0.644) and very good (K = 0.833) for conventional modes and CEUS, respectively. The diagnostic performance of CEUS was high for both readers (area ± standard error under the ROC curve: 0.966 ± 0.031 and 0.900 ± 0.055 for readers 1 and 2, respectively). There were 2 false-positive results and 1 false-negative result in patients with proliferative diabetic retinopathy. CEUS was effective in differentiating subretinal hemorrhage from hypovascular tumors.
  
  
  CONCLUSIONS
  CEUS can be used as a problem-solving technique when conventional ultrasound modes are not diagnostic for retinal/choroidal detachment and when intraocular lumps cannot be characterized as tumor or non-tumor masses on conventional modes. The evaluation of patients with proliferative diabetic retinopathy, however, may be problematic.
authors: Radiology, University of Trieste.
authors: M
authors: M
authors: Bertolotto
authors: Radiology, Ospedale S. Corona.
authors: G
authors: G
authors: Serafini
authors: Unit of Radiology, IRCCS Policlinico San Donato.
authors: L M
authors: LM
authors: Sconfienza
authors: Radiology, Ospedale S. Corona.
authors: F
authors: F
authors: Lacelli
authors: Radiology, University of Trieste.
authors: M
authors: M
authors: Cavallaro
authors: Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano.
authors: A
authors: A
authors: Coslovich
authors: Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano.
authors: D
authors: D
authors: Tognetto
authors: Radiology, University of Trieste.
authors: M A
authors: MA
authors: Cova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015862:Choroid Diseases / Q000000981:diagnostic imaging*; D003287:Contrast Media; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging; D008875:Middle Aged; D015588:Observer Variation; D012163:Retinal Detachment / Q000000981:diagnostic imaging*; D012166:Retinal Hemorrhage / Q000000981:diagnostic imaging*; D058471:Subretinal Fluid / Q000000981:diagnostic imaging*; D018615:Ultrasonography, Doppler, Color / Q000379:methods*
chemical_list: D003287:Contrast Media