title: Professional exposure to anaesthetic gases in health workers: estimate of some hepatic and renal tests.
abstract: OBJECTIVE
  The aim of this study is to estimate whether the occupational exposure to low dose of anaesthetic gases could cause alterations of haematochemical hepatic and renal parameters in the health workers of a city hospital.
  
  
  METHODS
  After excluding the main confounding factors, 154 exposed subjects and 98 not exposed controls were included in the study. The exposed subjects were divided in more exposed (group 1: n.54) and less exposed (group 2: n.100). Each worker included in this study underwent the CBC test (Complete Blood Count test). The differences between means were compared using the Student T test for unpaired data and considered significant when the p value was < 0.05.
  
  
  RESULTS
  The mean values of serum albumin, alpha 1, alpha 2, beta and gamma globulins were significantly decreased in health workers of both groups compared to controls. The mean values of serum creatinine and gamma-GT were significantly higher in health workers of group 2 compared to controls.
  
  
  CONCLUSIONS
  The obtained results suggest that occupational exposure to low dose of anaesthetic gases could influence haematochemical hepatic and renal parameters in exposed health workers.
authors: Department of Anatomy, Histology, Medical-Legal and the Orthopedics, Sapienza University of Rome, Italy. franc.tomei@alice.it
authors: T
authors: T
authors: Caciari
authors: A
authors: A
authors: Capozzella
authors: F
authors: F
authors: Tomei
authors: M
authors: M
authors: Fiaschetti
authors: M P
authors: MP
authors: Schifano
authors: P A
authors: PA
authors: Gioffrè
authors: L
authors: L
authors: Santoro
authors: B
authors: B
authors: Scala
authors: N
authors: N
authors: Nardone
authors: S
authors: S
authors: De Sio
authors: A
authors: A
authors: Chighine
authors: G
authors: G
authors: Tomei
authors: M V
authors: MV
authors: Rosati
mesh_terms: D000510:Alpha-Globulins / Q000378:metabolism; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D001609:Beta-Globulins / Q000378:metabolism; D015415:Biomarkers / Q000097:blood*; D001772:Blood Cell Count / Q000379:methods; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D006786:Hospitals, Urban; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism; D008297:Male; D008505:Medical Staff, Hospital; D009741:Nursing Staff, Hospital; D016273:Occupational Exposure / Q000009:adverse effects*; D018570:Risk Assessment; D012709:Serum Albumin / Q000378:metabolism; D005719:gamma-Globulins / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000510:Alpha-Globulins; D018685:Anesthetics, Inhalation; D001609:Beta-Globulins; D015415:Biomarkers; D007155:Immunologic Factors; D012709:Serum Albumin; D005719:gamma-Globulins; D003404:Creatinine; D005723:gamma-Glutamyltransferase