title: Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration.
abstract: The fullerene C60 is used in consumer products such as cosmetics owing to its antioxidative effects and is being developed for nanomedical applications. However, knowledge regarding the safety of fullerene C60, especially after oral administration, is sparse. Here, we examined the safety of fullerene C60 in mice after 7 d of exposure to orally administered polyvinylpyrrolidone (PVP)-wrapped fullerene C60 (PVP-fullerene C60). Mice treated with PVP-fullerene C60 showed few changes in the plasma levels of various markers of kidney and liver injury and experienced no significant hematologic effects. Furthermore, the histology of the colon of PVP-fullerene C60-treated mice was indistinguishable from that of control mice. These results suggest that PVP-fullerene C60 lacks toxicity after high-dose oral administration and indicate that PVP-fullerene C60 can be considered safe for oral medication. These data provide basic information that likely will facilitate the production of safe and effective forms of fullerene C60.
authors: Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
authors: K
authors: K
authors: Yamashita
authors: Y
authors: Y
authors: Yoshioka
authors: H
authors: H
authors: Pan
authors: M
authors: M
authors: Taira
authors: T
authors: T
authors: Ogura
authors: T
authors: T
authors: Nagano
authors: M
authors: M
authors: Aoyama
authors: K
authors: K
authors: Nagano
authors: Y
authors: Y
authors: Abe
authors: H
authors: H
authors: Kamada
authors: S I
authors: SI
authors: Tsunoda
authors: H
authors: H
authors: Aoshima
authors: H
authors: H
authors: Nabeshi
authors: T
authors: T
authors: Yoshikawa
authors: Y
authors: Y
authors: Tsutsumi
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000473:pathology; D000284:Administration, Oral; D000818:Animals; D001772:Blood Cell Count; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D003092:Colitis / Q000139:chemically induced / Q000473:pathology; D005260:Female; D037741:Fullerenes / Q000008:administration & dosage / Q000494:pharmacology*; D008027:Light; D051379:Mice; D008810:Mice, Inbred C57BL; D011205:Povidone; D012542:Scattering, Radiation; D016707:Tissue Fixation
chemical_list: D037741:Fullerenes; D011205:Povidone; C069837:fullerene C60