title: Synthesis of 2,4-dihydroxychalcone derivatives as potential antidepressant effect.
abstract: In this study, twelve 2,4-dihydroxychalcone derivatives were synthesized and evaluated for antidepressant activities using the forced swimming test (FST). The pharmacological test showed that 6 compounds significantly reduced the immobility times in the FST at a dose of 10 mg/kg, indicative of antidepressant activity. Among the derivatives, compounds designated 3d and 3 h exhibited the best antidepressant activity, with reduced immobility time by 32.05% and 34.33%, respectively. In the 5-hydroxytryptophan-induced head-twitch test and yohimbine-induced mortality test, compounds 3d and 3 h increased head-twitch and increased the mortality rate. The mechanisms of the antidepressant effects of compounds 3d and 3 h may be related with the 5-HTP and NE nervous system.
authors: Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan, China.
authors: L-P
authors: LP
authors: Guan
authors: D-H
authors: DH
authors: Zhao
authors: Y
authors: Y
authors: Chang
authors: Z-S
authors: ZS
authors: Wen
authors: L-M
authors: LM
authors: Tang
authors: F-F
authors: FF
authors: Huang
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D047188:Chalcones / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice
chemical_list: D000928:Antidepressive Agents; D047188:Chalcones