title: Fertility in women survivors of hematological malignancies: what is the real role of GnRH analogue treatment?
abstract: OBJECTIVE
  The aim of this study was to evaluate the ovarian function in women who received or not gonadotropin-releasing hormone (GnRH) analogue co-treatment compared to the control group that did not receive it.
  
  
  METHODS
  This study analyzed 124 patients affected by hematological diseases between 1998 and 2007. The data were analyzed using R (v 2.9.1).
  
  
  RESULTS
  In the women treated with GnRH analogue, the authors found 33% post-treatment secondary amenorrhea and 6% had a pregnancy post-treatment, while in the other group the prevalence were respectively 49% and 4% (p n.s.). Moreover, in multivariate analysis the authors found bone marrow transplantation to be a risk factor for secondary amenorrhea, while the association of chemotherapy with radiotherapy was a protective factor (p < 0.05). Finally, none of the considered factors were predictive of pregnancy achievement post-treatment.
  
  
  CONCLUSIONS
  The authors found no statistical evidence to support that Gn-RH analogue treatment preserves ovarian follicular reserve during hematologic cancer treatment, but more evidence must be obtained.
authors: Clinic of Obstetrics and Gynecology, Teaching Hospital SM della Misericordia, Udine, Italy.
authors: L
authors: L
authors: Driul
authors: A P
authors: AP
authors: Londero
authors: C
authors: C
authors: Papadakis
authors: A
authors: A
authors: Candoni
authors: S
authors: S
authors: Bertozzi
authors: R
authors: R
authors: Fanin
authors: D
authors: D
authors: Marchesoni
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D005298:Fertility; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D015999:Multivariate Analysis; D010053:Ovary / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced / Q000517:prevention & control*; D011446:Prospective Studies; D017741:Survivors; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D007987:Gonadotropin-Releasing Hormone