title: [Study on prescription of self-microemulsifying drug delivery system of mangiferin phospholipid complex].
abstract: OBJECTIVE
  To study formulation of self-microemulsifying drug delivery system (SMEDDS) of mangiferin phospholipid complex and improve dissolution and bioavailability of mangiferin.
  
  
  METHODS
  Ternary phase diagram was applied to optimize the prescription of self-microemulsifying drug delivery system of mangiferin phospholipid complex, and the best recipe was selected by comprehensive evaluation of the speed of microemulsifying, microemulsion size and electric potential.
  
  
  RESULTS
  The optimum formulation of SMEDDS was composed of IPM-Cremphor EL35-labrasol = 2 : 4.8 : 3.2.
  
  
  CONCLUSIONS
  Self-microemulsifying drug delivery system of mangiferin phospholipid complex can effectively improve the dissolution of Mangiferin.
authors: Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China. zijimei369@126.com
authors: Xiao-yu
authors: XY
authors: Xuan
authors: Ya-jing
authors: YJ
authors: Wang
authors: Hui
authors: H
authors: Tian
authors: Jia-xin
authors: JX
authors: Pi
authors: Shi-zhen
authors: SZ
authors: Sun
authors: Wei-ling
authors: WL
authors: Zhang
mesh_terms: D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D004655:Emulsions / Q000737:chemistry*; D005989:Glycerides; D006863:Hydrogen-Ion Concentration; D009227:Myristic Acids / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry; D010316:Particle Size; D010743:Phospholipids / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D044004:Xanthones / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D004655:Emulsions; D005989:Glycerides; D009227:Myristic Acids; D009930:Organic Chemicals; D010743:Phospholipids; D012997:Solvents; D044004:Xanthones; C440220:Labrasol; C013592:mangiferin