title: The sirtuin family's role in aging and age-associated pathologies.
abstract: The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be invoked by cells to aid in the defense against a vast array of stressors. The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and cancer, are either caused by or exacerbated by a lifetime of chronic stress. As such, the activation of sirtuin proteins could provide a therapeutic approach to buffer against chronic stress and ameliorate age-related decline. Here we review experimental evidence both for and against this proposal, as well as the implications that isoform-specific sirtuin activation may have for healthy aging in humans.
authors: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
authors: Jessica A
authors: JA
authors: Hall
authors: John E
authors: JE
authors: Dominy
authors: Yoonjin
authors: Y
authors: Lee
authors: Pere
authors: P
authors: Puigserver
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism / Q000503:physiopathology; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000503:physiopathology; D037761:Sirtuins / Q000378:metabolism / Q000502:physiology*
chemical_list: D037761:Sirtuins