title: Populene D analogues: design, concise synthesis and antiproliferative activity.
abstract: An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI(50) = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered.
authors: Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, CP 26077, CEP São Paulo 05513-970, SP, Brazil. analucia@cpqba.unicamp.br
authors: Kachi R Kishore Kumar
authors: KR
authors: Reddy
authors: Giovanna B
authors: GB
authors: Longato
authors: João E
authors: JE
authors: de Carvalho
authors: Ana L T G
authors: AL
authors: Ruiz
authors: Luiz F
authors: LF
authors: Silva
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D011714:Pyrans