title: [Gelatin-thrombin matrix-mediated hemostasis: application in tonsillectomy].
abstract: BACKGROUND
  To assess the feasibility of omitting thermal coagulation following cold knife tonsillectomy, we compared the use of a local thrombin hemostat (FloSeal®, FS) to bipolar electrocautery (EK).
  
  
  METHODS
  A total of 181 patients with chronic tonsillitis or tonsillar hypertrophy were stratified in terms of patient characteristics and randomized before undergoing tonsillectomy. The follow-up period continued until postoperative day 20.
  
  
  RESULTS
  FS-treated patients reported lower postoperative pain intensity scores (p = 0.011) and significantly reduced pain duration (p < 0.001). Whilst wound healing appeared to be improved in FS patients, the rates of postoperative hemorrhage remained unchanged. Use of an FS enabled inexperienced surgeons (< 100 procedures) to reduce their operating time by 8 min (p = 0.05), although no effect was observed for experienced surgeons.
  
  
  CONCLUSIONS
  Hemostasis is effectively mediated by an FS and its application reduces postoperative pain intensity and duration. Although we observed accelerated wound healing and reduced operating times owing to a more calculable rate of hemostasis, this did not influence the rates of postoperative hemorrhage.
authors: Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde/Plastische Operationen, Universität Leipzig, Liebigstrasse 10-14, 04103, Leipzig, Deutschland. christian.mozet@medizin.uni-leipzig.de
authors: C
authors: C
authors: Mozet
authors: C
authors: C
authors: Prettin
authors: M
authors: M
authors: Dietze
authors: A
authors: A
authors: Dietz
mesh_terms: D000328:Adult; D005240:Feasibility Studies; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use*; D005858:Germany / Q000453:epidemiology; D006488:Hemostasis, Surgical / Q000379:methods / Q000706:statistics & numerical data*; D006490:Hemostatics / Q000008:administration & dosage; D006801:Humans; D015994:Incidence; D008297:Male; D019106:Postoperative Hemorrhage / Q000453:epidemiology* / Q000517:prevention & control*; D012307:Risk Factors; D014068:Tonsillectomy / Q000706:statistics & numerical data*; D014069:Tonsillitis / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: C411004:FloSeal Matrix; D006490:Hemostatics