title: ECM: chemoattraction but not adhesion.
abstract: The mechanisms that regulate 3-dimensional (3D) neutrophil chemotaxis are poorly understood. In this issue of Blood, Afonso et al demonstrate that the collagen receptor Discoidin domain receptor 2 (DDR2) promotes neutrophil chemotaxis in 3D by triggering matrix metalloproteinase (MMP) activity and the generation of chemotactic collagen peptides.
authors: University of Wisconsin-Madison.
authors: Anna
authors: A
authors: Huttenlocher
mesh_terms: D002634:Chemotaxis, Leukocyte; D000070818:Discoidin Domain Receptors; D006801:Humans; D009504:Neutrophils / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D011975:Receptors, Mitogen / Q000502:physiology*; D046509:Tissue Culture Techniques
chemical_list: D011975:Receptors, Mitogen; D000070818:Discoidin Domain Receptors; D020794:Receptor Protein-Tyrosine Kinases