title: [mTORC1 and sirolimus: a link with fertility].
abstract: mTOR (mammalian target of rapamycin), a protein kinase highly conserved, is the catalytic subunit of two complexes, mTORC1 and mTORC2. These complexes are regulated by amino acids availability, by insulin and growth factors signaling pathways. Thus, mTORC1 and mTORC2 complexes are essential sensors of the cellular nutrient and energy levels in living organisms. mTORC1 is sensitive to rapamycin (also known as sirolimus), a drug prescribed in case of organ transplantation (kidney) due to its immunosuppressive and anti-proliferative properties. However, some studies have shown that the rapamycin treatment can induce fertility disorders. Thus, this article reviews the mTOR involvement in the male and female reproductive axis.
authors: Unité physiologie de la reproduction et des comportements, UMR 6073 Inra-CNRS-université F. Rabelais de Tours, Nouzilly, France. tartarinp@gmail.com
authors: Pauline
authors: P
authors: Tartarin
authors: Pascal
authors: P
authors: Froment
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D006066:Gonads / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D000076222:Mechanistic Target of Rapamycin Complex 1; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D020123:Sirolimus / Q000494:pharmacology*; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D000935:Antifungal Agents; D046912:Multiprotein Complexes; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus