title: Percutaneous vertebroplasty combined with interstitial implantation of 125I seeds in banna mini-pigs.
abstract: BACKGROUND
  Although brachytherapy is one of the most effective ways to treat metastatic spinal tumor with little damage to surrounding healthy tissue, it may cause radiation myelopathy if an overdose occurs. Establishing a valuable animal model can help to find a method to overcome its complications. In the current study, we set up a banna mini-pig model to mimic percutaneous vertebroplasty with 125I seed implantation.
  
  
  METHODS
  Percutaneous vertebroplasty (PVP) combined with interstitial implantation of 125I seeds, 125I seeds were transplanted into the vertebral body at the T13 level of the spine in banna mini-pigs. After raising them for up to eight months, the spinal cord and vertebral body were collected for pathological analysis.
  
  
  RESULTS
  A potential animal model had been successfully established, no case of radiation myelopathy was found in any of the treated banna pigs, and no significant cellular impairment was noted by pathological analysis.
  
  
  CONCLUSIONS
  It proves that PVP with 125I brachytherapy is an effective method to treat metastasis spinal tumor, and that the banna mini-pig can be a suitable model to investigate the mechanism of brachytherapy complications.
authors: Department of Orthopedics, Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, 650118, Kunming, Yunnan, PR China. yangzuozhangsci@163.com
authors: Zuozhang
authors: Z
authors: Yang
authors: Yu
authors: Y
authors: Zhang
authors: Da
authors: D
authors: Xu
authors: Giulio
authors: G
authors: Maccauro
authors: Barbara
authors: B
authors: Rossi
authors: Hua
authors: H
authors: Jiang
authors: Jiaping
authors: J
authors: Wang
authors: Hongpu
authors: H
authors: Sun
authors: Lei
authors: L
authors: Xu
authors: Yanjin
authors: Y
authors: Chen
authors: Xuefeng
authors: X
authors: Liu
mesh_terms: D000818:Animals; D001918:Brachytherapy; D003131:Combined Modality Therapy; D005260:Female; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement; D013125:Spinal Neoplasms / Q000556:secondary / Q000628:therapy*; D013552:Swine; D013556:Swine, Miniature; D014057:Tomography, X-Ray Computed; D054854:Vertebroplasty
chemical_list: D007457:Iodine Radioisotopes