title: The significance of non correlation between interleukin-8 serum levels with bone marrow microvascular density in patients with myeloma multiple.
abstract: In multiple myeloma (MM), angiogenesis plays a substantial role in disease progression. Interleukin-8 (IL-8), a pro-inflammatory chemokine with potent pro-angiogenic properties, has been implicated in the pathophysiology of MM. The aim of the study is to measure serum levels of IL-8 in MM patients and to correlate them with markers of angiogenesis, such as circulating levels of platelet derived growth factor-AB (PDGF-AB) and angiogenin (Ang), and bone marrow microvascular density (MVD). Fifty-three newly diagnosed MM patients, 23 of them, who reached plateau phase after effective treatment and 20 healthy controls, were studied. Serum levels of PDGF-AB, Ang and IL-8 were measured by ELISA, whereas bone marrow MVD was estimated by immunohistochemical staining of vessels with anti-CD31. All measured parameters were higher in MM patients compared to controls and in increased disease stages. They all also significantly decreased in plateau phase. IL-8 correlated positively with Ang and PDGF-AB, but not with MVD. The circulating levels of IL-8, PDGF-AB and Ang are elevated in patients with MM. The lack of correlation between IL-8 with MVD suggests that its levels represent the inflammatory element of MM disease and the participation in angiogenesis process is rather complex with multifactorial mechanisms.
authors: Hematology Department, Venizelion Hospital of Heraklion, Knossou Avenue, Zip Code 71409, Heraklion, Greece.
authors: Constantina A
authors: CA
authors: Pappa
authors: George
authors: G
authors: Tsirakis
authors: Anna
authors: A
authors: Boula
authors: Aikaterini
authors: A
authors: Sfiridaki
authors: Fotios E
authors: FE
authors: Psarakis
authors: Michael G
authors: MG
authors: Alexandrakis
authors: Efstathios N
authors: EN
authors: Stathopoulos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001853:Bone Marrow / Q000098:blood supply*; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D016014:Linear Models; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000097:blood / Q000473:pathology; D012259:Ribonuclease, Pancreatic / Q000097:blood; D018709:Statistics, Nonparametric
chemical_list: D016209:Interleukin-8; C046366:angiogenin; D012259:Ribonuclease, Pancreatic