title: Rapid inverse planning for pressure-driven drug infusions in the brain.
abstract: Infusing drugs directly into the brain is advantageous to oral or intravenous delivery for large molecules or drugs requiring high local concentrations with low off-target exposure. However, surgeons manually planning the cannula position for drug delivery in the brain face a challenging three-dimensional visualization task. This study presents an intuitive inverse-planning technique to identify the optimal placement that maximizes coverage of the target structure while minimizing the potential for leakage outside the target. The technique was retrospectively validated using intraoperative magnetic resonance imaging of infusions into the striatum of non-human primates and into a tumor in a canine model and applied prospectively to upcoming human clinical trials.
authors: Department of Neurosurgery, University of California San Francisco, San Francisco, California, United States of America. Kate.Rosenbluth@ucsf.edu
authors: Kathryn H
authors: KH
authors: Rosenbluth
authors: Alastair J
authors: AJ
authors: Martin
authors: Stephan
authors: S
authors: Mittermeyer
authors: Jan
authors: J
authors: Eschermann
authors: Peter J
authors: PJ
authors: Dickinson
authors: Krystof S
authors: KS
authors: Bankiewicz
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D057785:Catheters; D004285:Dogs; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D008954:Models, Biological; D010934:Planning Techniques; D011312:Pressure; D013997:Time Factors