title: Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study.
abstract: BACKGROUND
  White matter abnormalities can cause network dysfunction that underlies major depressive disorder (MDD). Diffusion tensor imaging (DTI) is used to examine the neural connectivity and integrity of the white matter. Previous studies have implicated frontolimbic neural networks in the pathophysiology of MDD. Approximately 30% of MDD patients demonstrate treatment-resistant depression (TRD). However, the neurobiology of TRD remains unclear.
  
  
  METHODS
  We used a voxel-based analysis method to analyze DTI data in young patients with TRD (n = 30; 19 males, 11 females) compared with right-handed, age- and sex-matched healthy volunteers (n = 25; 14 males, 11 females).
  
  
  RESULTS
  We found a significant decrease in fractional anisotropy (FA) (corrected, cluster size >50) in the left middle frontal gyrus (peak coordinates [-18 46-14]), left limbic lobe uncus (peak coordinates [-18 2-22]), and right cerebellum posterior lobe (peak coordinates [26-34 -40]). There was no increase in FA in any brain region in patients. We also found a significant negative correlation between mean regional FA values in the three areas and Beck Depression Inventory symptom scores.
  
  
  CONCLUSIONS
  We found significant differences in white matter FA in the frontal lobe, limbic lobe and cerebellum between TRD patients and controls. These data suggest that abnormalities of cortical-limbic-cerebellar white matter networks may contribute to TRD in young patients.
authors: Mental Health Institute, The 2nd Xiangya Hospital, Central South University, No, 139 Renmin Zhong Road, Changsha, 410011, China.
authors: Hong-jun
authors: HJ
authors: Peng
authors: Hui-rong
authors: HR
authors: Zheng
authors: Yu-ping
authors: YP
authors: Ning
authors: Yan
authors: Y
authors: Zhang
authors: Bao-ci
authors: BC
authors: Shan
authors: Li
authors: L
authors: Zhang
authors: Hai-chen
authors: HC
authors: Yang
authors: Jun
authors: J
authors: Liu
authors: Ze-xuan
authors: ZX
authors: Li
authors: Jian-song
authors: JS
authors: Zhou
authors: Zhi-jun
authors: ZJ
authors: Zhang
authors: Ling-jiang
authors: LJ
authors: Li
mesh_terms: D000328:Adult; D016880:Anisotropy; D000928:Antidepressive Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D002531:Cerebellum / Q000473:pathology*; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008032:Limbic System / Q000473:pathology*; D008297:Male; D009415:Nerve Net / Q000473:pathology; D011569:Psychiatric Status Rating Scales; D017211:Treatment Failure
chemical_list: D000928:Antidepressive Agents