title: Role of interleukin-33 in innate-type immune cells in allergy.
abstract: Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is preferentially and constitutively expressed in epithelial cells, and it is especially localized in the cells' nucleus. The nuclear IL-33 is released by necrotic cells after tissue injury and/or trauma, and subsequently provokes local inflammation as an alarmin, like high-mobility group box protein-1 (HMGB-1) and IL-1α. IL-33 mainly activates Th2 cells and such innate-type immune cells as mast cells, basophils, eosinophils and natural helper cells that express IL-33R (a heterodimer of IL-1 receptor-like 1 [IL-1RL1; also called ST2, T1, Der4, fit-1] and IL-1 receptor accessory protein [IL-1RAcP]). That activation causes the cells to produce Th2 cytokines, which contribute to host defense against nematodes. On the other hand, excessive and/or inappropriate production of IL-33 is also considered to be involved in the development of such disorders as allergy. In this review, we summarize current knowledge regarding the pathogenic roles of IL-33 in the development of allergic inflammation by focusing on its effects on innate-type immune cells.
authors: Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. snakae@ims.u-tokyo.ac.jp
authors: Susumu
authors: S
authors: Nakae
authors: Hideaki
authors: H
authors: Morita
authors: Tatsukuni
authors: T
authors: Ohno
authors: Ken
authors: K
authors: Arae
authors: Kenji
authors: K
authors: Matsumoto
authors: Hirohisa
authors: H
authors: Saito
mesh_terms: D000818:Animals; D001491:Basophils / Q000276:immunology / Q000378:metabolism; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000378:metabolism; D007113:Immunity, Innate; D053577:Interleukin-1 Receptor Accessory Protein / Q000378:metabolism; D000067596:Interleukin-33; D007378:Interleukins / Q000502:physiology*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D017472:Receptors, Interleukin-1 / Q000378:metabolism
chemical_list: C506536:IL33 protein, human; C506535:Il33 protein, mouse; D053577:Interleukin-1 Receptor Accessory Protein; D000067596:Interleukin-33; D007378:Interleukins; D017472:Receptors, Interleukin-1