title: Protective effect of white tea extract against acute oxidative injury caused by adriamycin in different tissues.
abstract: Adriamycin (ADR) is an anticancer agent that increases oxidative stress in cells. We evaluated the protective effect of the long term consumption of white tea at two different doses against this drug. For this purpose rats were given distilled water (controls), 0.15 mg (Dose 1) or 0.45 mg (Dose 2) of solid tea extract/kg body weight for 12 months. All the animals received an injection of ADR, except half of the control group, which were given an injection of saline solution. This gave four experimental groups: Control (C), C+ADR, Dose 1+ADR, and Dose 2+ADR. The antioxidant activity (in liver, heart and brain microsomes) was analysed. White tea consumption for 12 months, at a non-pharmacological dose, reversed the oxidative damage caused by ADR, on both protein and lipid levels in all three organs. The heart recovered its antioxidant activity only at the highest dose of tea.
authors: Physiology Department, Faculty of Biology, University of Murcia, 30100 Murcia, Spain. cespinosa31416@gmail.com
authors: Cristóbal
authors: C
authors: Espinosa
authors: José Ángel
authors: JÁ
authors: López-Jiménez
authors: Lorena
authors: L
authors: Cabrera
authors: Elvira
authors: E
authors: Larqué
authors: María Pilar
authors: MP
authors: Almajano
authors: Marino B
authors: MB
authors: Arnao
authors: Salvador
authors: S
authors: Zamora
authors: Francisca
authors: F
authors: Pérez-Llamas
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D028241:Camellia sinensis / Q000737:chemistry*; D004035:Diet Therapy; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress; D020011:Protective Agents / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D020011:Protective Agents; D013662:Tea; D004317:Doxorubicin