title: SEEKING and depression in stroke patients: an exploratory study.
abstract: The concept of SEEKING describes a predisposition to search enthusiastically for rewards in the environment. While SEEKING and its underlying functional anatomy have been extensively investigated in animals, such processes in humans, especially brain-damaged individuals, remain understudied. We therefore conducted an exploratory behavioral study in stroke patients to investigate the effects of brain lesions that anatomically could be interpreted to impact the SEEKING system and predicted relationships to depression. Patients with lesions in anterior, medial, and/or subcortical lesions showed significantly lower SEEKING scores and higher depression scores than nonlesioned subjects in the control group. Based on our data and related work on animals, we propose central involvement of the anterior subcortical-cortical midline system as core of the limbic system in SEEKING in humans.
authors: Clinical Psychology Service, Villa Bellombra, Rehabilitation Hospital, Bologna, Italy. marina.farinelli@unibo.it
authors: Marina
authors: M
authors: Farinelli
authors: Jaak
authors: J
authors: Panksepp
authors: Laura
authors: L
authors: Gestieri
authors: Maria Rosaria
authors: MR
authors: Leo
authors: Raffaele
authors: R
authors: Agati
authors: Monica
authors: M
authors: Maffei
authors: Marco
authors: M
authors: Leonardi
authors: Georg
authors: G
authors: Northoff
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D003863:Depression / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010551:Personality / Q000502:physiology*; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D020521:Stroke / Q000145:classification / Q000473:pathology / Q000503:physiopathology*