title: [Interaction between HIV-1 and GB virus type-C during coinfection status].
abstract: The human immunodeficiency virus (HIV) infection is one of the most important problems in public health. It is estimated that 3 3 million people are infected around the world. HIV and GBV-C share the same transmission route, being frequent the co-infection. Since both viruses replicate in CD4+ lymphocytes, recent studies have described an interaction. Decreasing of HIV viral load and higher CD4 counts have been observed in co-infected patients, leading a better clinical outcome. Nevertheless, some epidemiological studies have shown contradictory results. Additionally, in vitro models report inhibition of HIV by E1, E2, NS3 and NS5A GBV-C proteins, resulting in a decreasing of p24 antigen. This review summarizes the principal findings about co-infection and mechanisms that have been proposed for HIV-1 inhibition.
authors: Facultad de Ciencias Exactas y Aplicadas, Instituto Tecnológico Metropolitano, Medellín, Colombia.
authors: Johanna C
authors: JC
authors: Arroyave
authors: Flor H
authors: FH
authors: Pujol
authors: María C
authors: MC
authors: Navas
authors: Fabián M
authors: FM
authors: Cortés-Mancera
mesh_terms: D018791:CD4 Lymphocyte Count; D060085:Coinfection / Q000821:virology*; D018450:Disease Progression; D018178:Flaviviridae Infections / Q000150:complications / Q000276:immunology / Q000821:virology*; D029407:GB virus C / Q000276:immunology / Q000502:physiology*; D015658:HIV Infections / Q000150:complications / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000276:immunology / Q000821:virology*; D006801:Humans; D014762:Viral Interference / Q000502:physiology*; D019562:Viral Load / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology / Q000502:physiology; D014779:Virus Replication
chemical_list: D014764:Viral Proteins