title: Interleukin-1 receptor 2 keeps the lid on interleukin-1α.
abstract: The molecular mechanisms that regulate functional activation of IL-1α remain elusive. In this issue of Immunity, Zheng et al. (2013) describe a molecular system implicating interleukin-1 receptor-2 (IL-1R2) as a principal cytosolic factor that controls functional IL-1α activation during necrosis.
authors: Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195-7720, USA.
authors: Nelson C
authors: NC
authors: Di Paolo
authors: Dmitry M
authors: DM
authors: Shayakhmetov