title: [Th1/Th2 cytokines and its clinical significance in obstructive sleep apnea hypopnea syndrome children without allergic rhinitis and asthma].
abstract: OBJECTIVE
  To analyze Th1 and Th2 immune balance related cytokines and clinical significance in obstructive sleep apnea hypopnea syndrome children without allergic rhinitis and asthma.
  
  
  METHODS
  Collected 91 cases of obstructive sleep apnea hypopnea syndrome children with obstructive level data, and measured the serum Th1 cytokine TNF-beta and IFN-gamma, Th2 cytokines IL-4 and IL-5 levels. One hundred and five normal children were enrolled for the same detection of serum cytokines.
  
  
  RESULTS
  Non-allergic rhinitis and asthma children serum levels of IFN-gamma was lower than control group children, the difference was statistically significant (P < 0. 01). Other cytokines (TNF-beta, IL-4 and IL-5) were no significant difference with the control group.
  
  
  CONCLUSIONS
  Th1 and Th2 immune response was imbalance in non-allergic rhinitis and asthma obstructive sleep apnea hypopnea syndrome children. The decline in Th1 cell-mediated protective immune response cells may cause disease.
authors: Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai,200092, China.
authors: Jun
authors: J
authors: Shi
authors: Jingrong
authors: J
authors: Lv
authors: Hao
authors: H
authors: Wu
mesh_terms: D001249:Asthma; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015848:Interleukin-5 / Q000097:blood; D008233:Lymphotoxin-alpha / Q000097:blood; D008297:Male; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial; D020181:Sleep Apnea, Obstructive / Q000097:blood*; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*
chemical_list: D015848:Interleukin-5; D008233:Lymphotoxin-alpha; D015847:Interleukin-4; D007371:Interferon-gamma