title: The association of PTPN22 polymorphism with endometriosis: effect of genetic and clinical factors.
abstract: OBJECTIVE
  To investigate the possible effect of clinical and genetic variables on the association between PTPN22 and endometriosis.
  
  
  METHODS
  PTPN22, ACP₁ and p53 codon 72 genetic polymorphisms and duration of previous pharmacological treatment were studied. The study sample consisted of 132 women hospitalized for endometriosis diagnosed by laparoscopic intervention and histologically confirmed: 359 healthy blood donors were studied as controls. PTPN22, ACP1 and p53 codon 72 genotypes were determined by DNA analysis. Discriminant statistical analysis, logistic regression analysis, chi square of independence, power test and linear correlation were performed using SPSS programs.
  
  
  RESULTS
  A significant increase of PTPN22 *T allele in endometriosis is observed in women carrying ACP1*C allele, in women carrying p53 codon 72 *Pro allele and in women with prolonged pharmacological treatment.
  
  
  CONCLUSIONS
  PTPN22 may not be a primary factor in the etiology of endometriosis but may cooperate with clinical and genetic factors influencing susceptibility and clinical course of disease. These new observations point to a multifactorial origin of endometriosis and help to explain the reported differences between human populations concerning the association between PTPN22 and endometriosis.
authors: Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. gloria@med.uniroma2.it
authors: F
authors: F
authors: Gloria-Bottini
authors: M
authors: M
authors: Ammendola
authors: P
authors: P
authors: Saccucci
authors: A
authors: A
authors: Pietropolli
authors: A
authors: A
authors: Magrini
authors: E
authors: E
authors: Bottini
mesh_terms: D000328:Adult; D000483:Alleles; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D006801:Humans; D011110:Polymorphism, Genetic; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; C490429:ACP1 protein, human; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; D017027:Protein Tyrosine Phosphatases