title: Relationship between postprandial glucose level and carotid artery stiffness in patients without diabetes or cardiovascular disease.
abstract: BACKGROUND
  The aim of this study was to evaluate the relationship between postprandial glucose level and atherosclerosis in patients without diabetes and cardiovascular disease by determining carotid ultrasonographic variables and serum levels of 1,5-anhydroglucitol (1,5-AG).
  
  
  METHODS
  The subjects were 72 patients without diabetes and cardiovascular disease being treated for hypertension or dyslipidemia. The clinical characteristics of all subjects, including the serum level of 1,5-AG, which appears to be well suited for monitoring postprandial hyperglycemia, were evaluated after an overnight fast. The average intima-media thickness (IMT) and the average pulsatility index (PI) of the right and left common carotid arteries were determined with high-resolution ultrasonography and used as ultrasonographic variables. The subjects were divided into a lower 1,5-AG group (n = 36) and a higher 1,5-AG group (n = 36). We evaluated the relationship between clinical characteristics and ultrasonographic variables of the carotid artery in both groups.
  
  
  RESULTS
  The average PI in the Lower 1,5-AG group was significantly higher than that in the Higher 1,5-AG group, but the average IMT did not differ between the groups. Linear regression analysis, with the ultrasonographic variables as the dependent variables, with 1,5-AG as the independent variable, and adjusted for other clinical characteristics, showed significant correlation between 1,5-AG and the PI but not between 1,5-AG and IMT.
  
  
  CONCLUSIONS
  Our results suggest that postprandial hyperglycemia increases carotid artery stiffness, but not morphological change, in patients without diabetes or cardiovascular disease.
authors: Department of Internal Medicine, Divisions of Cardiology, Hepatology, Geriatrics, and Integrated Medicine, Nippon Medical School, 1-1-5 Sendagi, 113-8603, Bunkyo-ku, Tokyo, Japan. kentaro@nms.ac.jp
authors: Kentaro
authors: K
authors: Watanabe
authors: Tatsuya
authors: T
authors: Suzuki
authors: Motoshi
authors: M
authors: Ouchi
authors: Kazunari
authors: K
authors: Suzuki
authors: Makoto
authors: M
authors: Ohara
authors: Masao
authors: M
authors: Hashimoto
authors: Hidetoshi
authors: H
authors: Yamashita
authors: Masaru
authors: M
authors: Okazaki
authors: Kazuhito
authors: K
authors: Ishii
authors: Kenzo
authors: K
authors: Oba
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D003847:Deoxyglucose / Q000097:blood; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D019518:Postprandial Period; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis; D012307:Risk Factors; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose