title: Effects of marathon running on cardiac markers and endothelin-1 in EIH athletes.
abstract: The aim of the present study was to determine the changes in cardiac makers and endothelin-1 (ET-1) in marathoners with exercise induced hypertension compared to normotensive controls before and after running a marathon. Among a total of 70 volunteers, 10 marathoners with systolic blood pressure (SBP) greater than 210 mmHg during a treadmill exercise stress test were selected as an exercise-induced hypertension group (EIH) and 10 marathoners with normal SBP were selected as a control group (CON). Blood was collected from all volunteers 2 h before and immediately after a marathon: creatinine kinase (CK), CK-MB, cardiac tropoin-I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), and endothelin-1(ET-1). Cardiac markers, CK, CK-MB, and CK-MB/CK ratio significantly increased in both EIH and CON; significance was not observed between the groups. Significant increases were not observed in high sensitive-C reactive protein (hs-CRP) after the race nor between the groups. Significant increases in cTnI and NT-proBNP were observed after the race in both groups. In addition, EIH showed greater increase than CON after the race. In conclusion, increased vascular tone in EIH during a marathon increased blood pressure and myocardial burden which in turn increased myocardial cell membrane permeability to further increase myocardial tension to the point of cTnI release.
authors: Department of Rehabilitation Medicine, Inje University Paik Hospital, Seoul, Republic of Korea.
authors: Y J
authors: YJ
authors: Kim
authors: Y O
authors: YO
authors: Shin
authors: Y H
authors: YH
authors: Lee
authors: H M
authors: HM
authors: Jee
authors: K A
authors: KA
authors: Shin
authors: C W
authors: CW
authors: Goh
authors: C H
authors: CH
authors: Kim
authors: Y K
authors: YK
authors: Min
authors: H M
authors: HM
authors: Yang
authors: J B
authors: JB
authors: Lee
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D016022:Case-Control Studies; D002463:Cell Membrane Permeability / Q000502:physiology; D019332:Endothelin-1 / Q000378:metabolism*; D005080:Exercise Test; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D012420:Running / Q000502:physiology*; D019210:Troponin I / Q000378:metabolism
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain