title: Roles for BLyS family members in meeting the distinct homeostatic demands of innate and adaptive B cells.
abstract: B-1 and B-2 B cell populations have different progenitors, receptor diversity, anatomic location, and functions - suggesting vastly differing requisites for homeostatic regulation. There is evidence that the B lymphocyte stimulator (BLyS) family of cytokines and receptors, key factors in the homeostatic regulation of B-2 B cell subsets, is also a major player in the B-1 compartment. Here we review the development and differentiation of these two primary B cell lineages and their immune functions. We discuss evidence that BLyS or a proliferation-inducing ligand (APRIL) availability in different anatomic sites, coupled with signature BLyS receptor expression patterns on different B cell subsets, may be important for homeostatic regulation of B-1 as well as B-2 populations. Finally, we extend our working model of B cell homeostasis to integrate B-1s.
authors: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA.
authors: Vishal J
authors: VJ
authors: Sindhava
authors: Jean L
authors: JL
authors: Scholz
authors: Michael P
authors: MP
authors: Cancro
keywords: B-1 cells; B-2 cells; BLyS; homeostasis; innate B cells