title: Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays.
abstract: OBJECTIVE
  The data available on reference ranges for cystatin C in children are limited, and there are discrepancies among the available data. The aim of this study was to describe the reference ranges for cystatin C in Japanese children by using 4 automated assays.
  
  
  METHODS
  Serum cystatin C levels were measured in 1128 Japanese children aged 3 month to 16 years without kidney disease. We calculated age-, gender-, race- and assay-specific cystatin C ranges.
  
  
  RESULTS
  For all 4 assays, the median serum cystatin C levels were raised in term infants compared with older children and decreased by the first 2 years. The median serum cystatin C levels remained constant throughout up to the age of 14 years and decreased in children aged 15-16 years. The median serum cystatin C levels in children aged 12-16 years were slightly higher in males than in females. Assay-specific differences were also observed in the levels of serum cystatin C measured.
  
  
  CONCLUSIONS
  Age-, gender-, race- and assay-specific ranges for serum cystatin C should be used as another tool to assess kidney function in children.
authors: The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan, nahoko_yata@tmhp.jp.
authors: Nahoko
authors: N
authors: Yata
authors: Osamu
authors: O
authors: Uemura
authors: Masataka
authors: M
authors: Honda
authors: Takeshi
authors: T
authors: Matsuyama
authors: Kenji
authors: K
authors: Ishikura
authors: Hiroshi
authors: H
authors: Hataya
authors: Takuhito
authors: T
authors: Nagai
authors: Yohei
authors: Y
authors: Ikezumi
authors: Naoya
authors: N
authors: Fujita
authors: Shuichi
authors: S
authors: Ito
authors: Kazumoto
authors: K
authors: Iijima
authors: Mari
authors: M
authors: Saito
authors: Tetsuji
authors: T
authors: Keneko
authors: Teruo
authors: T
authors: Kitagawa
mesh_terms: D000293:Adolescent; D044466:Asian People; D001322:Autoanalysis / Q000592:standards; D002648:Child; D002675:Child, Preschool; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012016:Reference Values
chemical_list: D055316:Cystatin C