title: The changing epidemiology of liver disease in HIV patients.
abstract: Liver disease continues to be one of the leading causes of hospitalization and death in HIV-infected individuals. Important etiologies include both alcoholic and non-alcoholic steatohepatitis, and coinfection with hepatitis viruses B and C. While non-alcoholic fatty liver disease is increasingly diagnosed in this population, most cases of chronic hepatitis B can be well controlled with tenofovir-based regimens, and hepatitis C has entered a revolutionary era in which most patients may be cured with direct-acting antivirals. However, important gaps remain unaddressed. Hepatitis delta is a neglected disease, despite 15 million people being infected worldwide, and represents the most severe form of viral hepatitis. Hepatitis E is largely unrecognized, despite being the major cause of acute viral hepatitis worldwide and occasionally leading to chronicity in immunosuppressed individuals.
authors: Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain. vsoriano@dragonet.es
authors: Vincent
authors: V
authors: Soriano
authors: Pablo
authors: P
authors: Barreiro
authors: Kenneth E
authors: KE
authors: Sherman
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D060085:Coinfection; D018450:Disease Progression; D058625:End Stage Liver Disease / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D005234:Fatty Liver / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D006509:Hepatitis B / Q000453:epidemiology; D006526:Hepatitis C / Q000453:epidemiology; D003699:Hepatitis D / Q000453:epidemiology; D006525:Hepatitis, Viral, Human / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents