title: Synthesis of imidazo and benzimidazo[2,1-a]isoquinolines by rhodium-catalyzed intramolecular double C-H bond activation.
abstract: The rhodium-catalyzed intramolecular direct arylation of imidazole and benzimidazole derivatives via double C-H bond activation is described. This approach provides new access to a wide range of imidazo and benzimidazo[2,1-a]isoquinoline derivatives in moderate to high yields. This reaction provides an alternative method to the known Pd-catalyzed intramolecular oxidative cross-coupling reactions.
authors: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
authors: Vutukuri Prakash
authors: VP
authors: Reddy
authors: Takanori
authors: T
authors: Iwasaki
authors: Nobuaki
authors: N
authors: Kambe
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry; D003500:Cyclization; D005456:Fluorescent Dyes / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D012995:Solubility
chemical_list: D001562:Benzimidazoles; D005456:Fluorescent Dyes; D007093:Imidazoles; D007546:Isoquinolines; D012238:Rhodium; C039109:isoquinoline