title: Factor V Leiden mutation-related chronic skin ulcers.
abstract: Chronic skin ulcers require extensive, systemic differential diagnosis; thus, they are difficult to diagnose and treat. Transient or persistent hypercoagulable states are among the rare causes of skin ulcers. Here, we present the case of a 27-year-old woman patient with recurrent, nonhealing skin ulcers of 8 years' duration, who had been treated unsuccessfully with various medications under different diagnoses at different clinics. On admission, a skin biopsy demonstrated occlusive vasculopathy, and the search for an inherited hypercoagulable state revealed a heterozygous factor V Leiden mutation. The patient was treated with anticoagulants and hyperbaric oxygen. On treatment, the skin lesions healed and did not recur.
authors: Haydarpasa Numune Training and Research Hospital, Üsküdar, Istanbul, Turkey.
authors: Kadir
authors: K
authors: Kayatas
authors: Filiz
authors: F
authors: Cebeci
authors: Cumali
authors: C
authors: Karatoprak
authors: Muhammet
authors: M
authors: Benzer
authors: Refik
authors: R
authors: Demirtunç
authors: Cuyan
authors: C
authors: Demirkesen
mesh_terms: D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D004247:DNA / Q000235:genetics*; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005165:Factor V / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017354:Point Mutation; D012008:Recurrence; D017445:Skin Diseases, Vascular / Q000097:blood / Q000150:complications* / Q000235:genetics; D012883:Skin Ulcer / Q000097:blood / Q000209:etiology / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D004247:DNA