title: Self-regulation in a minimal model of chemical self-replication.
abstract: In biological systems, regulation plays an important role in keeping metabolite concentrations within physiological ranges. To study the dynamical implications of self-regulation, we consider a functional form used in genetic networks and couple it to a mechanism associated with chemical self-replication. For the two-variable minimal model, we find that activation can yield chemical toggles similar to those reported for gene repression in E. coli as well as more complex dynamics.
authors: Department of Chemistry, Williams College, Williamstown, MA 01267 USA.
authors: Sylvia J
authors: SJ
authors: Lou
authors: Enrique
authors: E
authors: Peacock-López
keywords: Bistability; Chemical self-replication; Genetic regulation