title: Suppression of Sclerostin and Dickkopf-1 levels in patients with fluorine bone injury.
abstract: Evidence has been accumulating for the role of Sclerostin and Dickkopf-1 as the antagonists of Wnt/β-Catenin signaling pathway, which suppresses bone formation through inhibiting osteoblastic function. To get deep-inside information about the expression of the antagonists in patients with fluorine bone injury, a case-control study was conducted in two counties in Hubei Province. Urinary and serum fluoride were significantly higher in patients with fluorine bone injury than in healthy controls. Additionally, patients with fluorine bone injury had significantly lower serum Sclerostin and Dickkopf-1 levels compared with healthy controls (P<0.001). Serum Sclerostin and Dickkopf-1 levels were significantly correlated with serum fluoride in all studied subjects (n=186). Low Sclerostin and Dickkopf-1 levels were associated with a significantly increased risk of fluorine bone injury. In conclusion, serum Sclerostin and Dickkopf-1 might be used as important markers of bone metabolism change and potential therapeutic targets to treat fluorine bone injury.
authors: Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors: Wenpeng
authors: W
authors: Wang
authors: Jian
authors: J
authors: Xu
authors: Kejian
authors: K
authors: Liu
authors: Xiaoli
authors: X
authors: Liu
authors: Changcheng
authors: C
authors: Li
authors: Caiyan
authors: C
authors: Cui
authors: Yuzeng
authors: Y
authors: Zhang
authors: Huabing
authors: H
authors: Li
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D001847:Bone Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000378:metabolism*; D019485:Bone Morphogenetic Proteins / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005459:Fluorides / Q000097:blood / Q000633:toxicity* / Q000652:urine; D005819:Genetic Markers; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; C501126:DKK1 protein, human; D005819:Genetic Markers; D036341:Intercellular Signaling Peptides and Proteins; C422903:SOST protein, human; D005459:Fluorides