title: Increased skin inflammation and blood vessel density in human and experimental diabetes.
abstract: Systemic inflammation is associated with impaired wound healing in diabetes mellitus (DM) patients. Using immunohistochemistry techniques, the authors investigated changes in skin inflammation and skin blood vessels in human and experimental diabetes. Comparing to the non-DM human subjects, the total number of inflammatory cells per biopsy and the number of inflammatory cells around blood vessels, a strong indication of inflammation, were higher in DM subjects irrespective of their risk for developing diabetic foot ulcer. Inflammatory cell infiltration was robustly increased in all DM animal models compared with their non-DM controls. The number and density of blood vessels and CD31 positive proliferating endothelial cells around preexisting skin vessels was also higher in the DM patients. However, there were no differences in the skin blood flow between the non-DM and DM subjects. The number of skin blood vessels was also increased in the DM animals; however, these differences were less obvious than the ones observed for inflammatory cells. We conclude that skin inflammation and skin blood vessel density is increased in diabetic human subjects and in rodent and rabbit models of diabetes.
authors: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
authors: Ana
authors: A
authors: Tellechea
authors: Antonios
authors: A
authors: Kafanas
authors: Ermelindo C
authors: EC
authors: Leal
authors: Francesco
authors: F
authors: Tecilazich
authors: Sarada
authors: S
authors: Kuchibhotla
authors: Michael E
authors: ME
authors: Auster
authors: Iraklis
authors: I
authors: Kontoes
authors: Jacqueline
authors: J
authors: Paolino
authors: Eugenia
authors: E
authors: Carvalho
authors: Leena Pradhan
authors: LP
authors: Nabzdyk
authors: Aristidis
authors: A
authors: Veves
mesh_terms: D000818:Animals; D001706:Biopsy; D001808:Blood Vessels / Q000473:pathology* / Q000503:physiopathology; D003872:Dermatitis / Q000150:complications / Q000473:pathology*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D017719:Diabetic Foot / Q000209:etiology / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D011446:Prospective Studies; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply* / Q000473:pathology