title: Economic evaluation of micafungin versus caspofungin for the treatment of candidaemia and invasive candidiasis.
abstract: BACKGROUND
  Micafungin demonstrated non-inferiority to caspofungin as definitive therapy for candidaemia and invasive candidiasis (IC) in a major randomised clinical trial.
  
  
  OBJECTIVE
  The aim of this study was to investigate if micafungin is a cost-saving option compared with caspofungin for treating candidaemia and IC.
  
  
  METHODS
  A decision analytical model was constructed to capture downstream consequences of using either agent as initial therapy for candidaemia and IC. The main outcomes were treatment success and treatment failure (i.e. death, mycological persistence, emergent infection, clinical failure but microbiological success). Outcome probabilities and treatment pathways were derived from the literature. Cost inputs were from the latest Australian resources, and resource use was estimated by expert panel. The analysis was from the Australian hospital perspective. Sensitivity analyses using Monte Carlo simulation were conducted.
  
  
  RESULTS
  Micafungin (AU$52 816) was associated with a lower total cost than caspofungin (AU$52 976), with a net cost-saving of $160 per patient. This was primarily due to the lower cost associated with alternative antifungal treatment in the micafungin arm. Hospitalisation was the main cost-driver for both arms. The model outcome was most sensitive to the proportion of treatment success in the micafungin arm. Uncertainty analysis demonstrated that micafungin had a 58% chance of being cost-saving compared with caspofungin.
  
  
  CONCLUSIONS
  Micafungin was cost-equivalent to caspofungin in treating candidaemia and IC, with variation in drug acquisition cost the critical factor.
authors: Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University (Parkville campus), Australia.
authors: C F
authors: CF
authors: Neoh
authors: D
authors: D
authors: Liew
authors: M A
authors: MA
authors: Slavin
authors: D
authors: D
authors: Marriott
authors: S C-A
authors: SC
authors: Chen
authors: O
authors: O
authors: Morrissey
authors: K
authors: K
authors: Stewart
authors: D C M
authors: DC
authors: Kong
mesh_terms: D000935:Antifungal Agents / Q000191:economics* / Q000627:therapeutic use; D058387:Candidemia / Q000188:drug therapy* / Q000191:economics*; D058365:Candidiasis, Invasive / Q000188:drug therapy / Q000191:economics; D000077336:Caspofungin; D003362:Cost-Benefit Analysis / Q000191:economics; D054714:Echinocandins / Q000191:economics* / Q000627:therapeutic use; D006801:Humans; D055666:Lipopeptides / Q000191:economics* / Q000627:therapeutic use; D000077551:Micafungin; D018803:Models, Economic; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin; D000077551:Micafungin