title: Industrial applications of the Diels-Alder reaction.
abstract: The Diels-Alder reaction is one of the most popular transformations for organic chemists to generate molecular complexity efficiently. Surprisingly, little is known about its industrial application for the synthesis of pharmacologically active ingredients, agrochemicals, and flavors and fragrances. This Review highlights selected examples, with a focus on large-scale applications (>1 kg) from a process research and development perspective.
authors: Process Research Chemistry, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, 4123 Allschwil, Switzerland. jacques.funel@actelion.com
authors: Jacques-Alexis
authors: JA
authors: Funel
authors: Stefan
authors: S
authors: Abele
mesh_terms: D016573:Agrochemicals / Q000138:chemical synthesis / Q000737:chemistry; D003358:Cosmetics / Q000138:chemical synthesis / Q000737:chemistry; D061565:Cycloaddition Reaction; D005421:Flavoring Agents / Q000138:chemical synthesis / Q000737:chemistry; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D016573:Agrochemicals; D003358:Cosmetics; D005421:Flavoring Agents; D009930:Organic Chemicals; D004364:Pharmaceutical Preparations