title: Placental weight relative to birthweight in pregnancies with maternal diabetes mellitus.
abstract: OBJECTIVE
  To study the association of maternal diabetes mellitus with placental weight, birthweight and placental weight-to-birthweight ratio.
  
  
  METHODS
  Population-based study.
  
  
  METHODS
  Medical Birth Registry of Norway.
  
  
  METHODS
  All singleton births in Norway during 1999-2008 (n = 536,997).
  
  
  METHODS
  We compared the distribution of placental weight z-scores and placental weight-to-birthweight ratio between pregnancies with and without diabetes. The associations of diabetes with placental weight z-scores were also estimated as odds ratios with and without adjustment for birthweight, maternal age, parity, preeclampsia, smoking and cesarean delivery.
  
  
  METHODS
  Placental weight, birthweight and placental weight-to-birthweight ratio.
  
  
  RESULTS
  Mean placental weight was 736.6 g in diabetic pregnancies and 672.1 g in non-diabetic pregnancies. The corresponding birthweights were 3682.1 g and 3557.0 g. In diabetic pregnancies, 26.2% of the placentas were in the highest decile of placental weight z-score, as compared with 9.7% in non-diabetic pregnancies (p < 0.001). The corresponding figures for being in the highest decile of placental weight-to-birthweight ratio were 18.2 and 9.9% (p < 0.001). The crude odds ratio for having a placenta in the highest decile of placental weight z-score was 3.29 (95% confidence interval 3.14-3.45) in diabetic pregnancies with non-diabetic pregnancies as the reference. After adjustment for birthweight and other variables, the odds ratio was 2.42 (95% confidence interval 2.29-2.56).
  
  
  CONCLUSIONS
  In diabetic pregnancies, placental weight as well as placental weight relative to birthweight were higher than in non-diabetic pregnancies.
authors: Department of Gynecology and Obstetrics, Akershus University Hospital and Institute of Clinical Medicine, University of Oslo, Lørenskog, Norway.
authors: Ellen M
authors: EM
authors: Strøm-Roum
authors: Camilla
authors: C
authors: Haavaldsen
authors: Tom G
authors: TG
authors: Tanbo
authors: Anne
authors: A
authors: Eskild
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009664:Norway; D016017:Odds Ratio; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D012042:Registries