title: Dysfunctions at human intestinal barrier by water-borne protozoan parasites: lessons from cultured human fully differentiated colon cancer cell lines.
abstract: Some water-borne protozoan parasites induce diseases through their membrane-associated functional structures and virulence factors that hijack the host cellular molecules and signalling pathways leading to structural and functional lesions in the intestinal barrier. In this Microreview we analyse the insights on the mechanisms of pathogenesis of Entamoeba intestinalis, Giardia and Cryptosporidium observed in the human colon carcinoma fully differentiated colon cancer cell lines, cell subpopulations and clones expressing the structural and functional characteristics of highly specialized fully differentiated epithelial cells lining the intestinal epithelium and mimicking structurally and functionally an intestinal barrier.
authors: CNRS, UMR 8076 BioCIS, Team Antiparasitic chemotherapy, Faculty of Pharmacy, Châtenay-Malabry, 92296, France. vanessa.lievin-lemoal@u-psud.fr
authors: Vanessa
authors: V
authors: Liévin-Le Moal
mesh_terms: D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability / Q000502:physiology*; D003106:Colon / Q000469:parasitology* / Q000473:pathology / Q000503:physiopathology*; D003110:Colonic Neoplasms / Q000469:parasitology* / Q000473:pathology / Q000503:physiopathology*; D003458:Cryptosporidium / Q000472:pathogenicity / Q000502:physiology; D004747:Entamoeba / Q000472:pathogenicity / Q000502:physiology; D005872:Giardia / Q000472:pathogenicity / Q000502:physiology; D006790:Host-Parasite Interactions / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000469:parasitology / Q000473:pathology / Q000503:physiopathology; D008871:Microvilli / Q000469:parasitology / Q000473:pathology / Q000502:physiology