title: Gua Lou Gui Zhi decoction exerts neuroprotective effects on post-stroke spasticity via the modulation of glutamate levels and AMPA receptor expression.
abstract: Spasticity is one of the most physically debilitating disabilities following stroke and may slow down the potential success of rehabilitation. Glutamate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors have been shown to play a crucial role in spasticity following cerebral ischemia/reperfusion (I/R) injury. Gua Lou Gui Zhi decoction (GLGZD) is a well-known traditional Chinese formula that has long been used clinically in China to treat muscular spasticity following stroke, epilepsy or spinal cord injury. However, the precise mechanisms behind its neuroprotective and anti-spasticity effects remain poorly understood. In the present study, using a rat model of focal cerebral I/R injury, we evaluated the neuroprotective and anti-spasticity effects of GLGZD and investigated the underlying mechanisms. We found that GLGZD improved neurological deﬁcits and reduced infarct volumes in cerebral I/R-injured rats. In addition, GLGZD reduced cerebral ischemic spasticity since it improved the screen test and Hoffman's reflex (H-reflex) scores. It also reduced glutamate levels in the cerebrospinal fluid and altered the expression of the AMPA receptor subunits. Our data demonstrate that GLGZD exerts neuroprotective and anti-spasticity effects in a cerebral ischemia model via the modulation of glutamate levels and AMPA receptor expression.
authors: College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Minhou Shangjie, Fuzhou, Fujian 350108, PR China.
authors: Jia
authors: J
authors: Huang
authors: Jing
authors: J
authors: Tao
authors: Xiehua
authors: X
authors: Xue
authors: Shanli
authors: S
authors: Yang
authors: Ping
authors: P
authors: Han
authors: Zhicheng
authors: Z
authors: Lin
authors: Wei
authors: W
authors: Xu
authors: Jiumao
authors: J
authors: Lin
authors: Jun
authors: J
authors: Peng
authors: Lidian
authors: L
authors: Chen
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002544:Cerebral Infarction / Q000473:pathology / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D018698:Glutamic Acid / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D009128:Muscle Spasticity / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000032:analysis / Q000378:metabolism*; D015427:Reperfusion Injury / Q000473:pathology / Q000503:physiopathology
chemical_list: D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D018091:Receptors, AMPA; C584294:gua lou gui zhi; D018698:Glutamic Acid