title: [Hypereosinophilic syndrome].
abstract: Hypereosinophilic syndrome is a heterogeneous group of diseases characterized by blood hypereosinophilia and eosinophil-related organ damage. A comprehensive diagnostic work-up is necessary to identify underlying conditions and to detect organ involvement, which are important for prognosis. Involvement of the heart is related with a poorer outcome. Some underlying conditions can be treated with targeted therapies, e.g., tyrosine kinase inhibitors. However, glucocorticoids in combination with steroid-sparing drugs are generally used for treatment. Furthermore, the growing understanding of the molecular pathogenesis will lead to new therapies, e.g., the use of anti-cytokine antibodies.
authors: Klinikum Bad Bramstedt und Universitätsklinikum Schleswig-Holstein, Oskar-Alexander-Str. 26, 24576 Bad Bramstedt. f.moosig@klinikumbb.de
authors: F
authors: F
authors: Moosig
authors: G
authors: G
authors: Richardt
authors: C
authors: C
authors: Merten
authors: W L
authors: WL
authors: Gross
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D005938:Glucocorticoids