title: [Selectins as adhesion molecules and potential therapeutic target].
abstract: Selectins belong to the family of adhesion molecules that recognize sugars as ligands through their Carbohydrate Recognition Domain (CRD). There are three types of selectin: the L-selectin (CD62L), which is constitutively expressed by most leukocyte populations, the P-selectin (CD62P) is found on activated platelets and endothelial cells, and the E-selectin (CD62E) expressed by activated endothelial cells. These three molecules exhibit high homology in their structures. Selectin-ligand interactions are among the most studied protein-glycan interactions in biology. The selectins and theirs ligands are involved in regulating inflammatory and immunological events that occur at the interface of the bloodstream and vessel walls. Their molecular partners are surface glycoconjugates harboring groups of the sialyl-Lewis antigens. This review presents an inventory of our current knowledge on the structures and functions of selectins and their ligands. We also provide an update on their involvement in pathophysiological processes, especially during inflammation and tumor development.
authors: Laboratoire des Venins et Toxines, Institut Pasteur de Tunis 13, Place Pasteur 1002 Tunis Belvédère, Tunisie.
authors: J
authors: J
authors: Jebali
authors: C
authors: C
authors: Jeanneau
authors: A
authors: A
authors: Bazaa
authors: S
authors: S
authors: Mathieu
authors: M
authors: M
authors: El Ayeb
authors: J
authors: J
authors: Luis
authors: A
authors: A
authors: El Battari
authors: N
authors: N
authors: Marrakchi
mesh_terms: D015815:Cell Adhesion Molecules; D006801:Humans; D058990:Molecular Targeted Therapy; D019087:Selectins / Q000502:physiology*
chemical_list: D015815:Cell Adhesion Molecules; D019087:Selectins