title: Effects of sesamin on streptozotocin (STZ)-induced NIT-1 pancreatic β-cell damage.
abstract: The protective effect of sesamin (SES) from sesame meal on NIT-1 pancreatic β-cells damaged by streptozotocin (STZ) in vitro was investigated. The cell viability, insulin secretion, the activity of superoxide dismutase(SOD), glutathione peroxidase (GSHpx) and the content of reduced glutathione (GSH) increased significantly when incubated with SES (400, 200 µg mL-1). The content of malondialdehyde (MDA), nitric oxide (NO) production, and the activity of NO synthase (NOS), inducible NOS (iNOS), decreased significantly when incubated with SES. The destructive changes of NIT-1 cells were ameliorated when treated with SES under microscopic observation. These data suggested that SES had obvious protective effect on NIT-1 pancreatic β-cells damaged by STZ, which might be related to its effects of decreasing levels of β-cell-destroying factors such as oxidative stress and NO synthesis.
authors: School of Biology and food engineering, Hefei University of Technology, Hefei 230009, China. leihong16@hotmail.com.
authors: Hong
authors: H
authors: Lei
authors: Juncheng
authors: J
authors: Han
authors: Qin
authors: Q
authors: Wang
authors: Shuzhen
authors: S
authors: Guo
authors: Hanju
authors: H
authors: Sun
authors: Xiaoxiang
authors: X
authors: Zhang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004149:Dioxoles / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000378:metabolism* / Q000473:pathology; D017705:Lignans / Q000494:pharmacology*; D051379:Mice; D013311:Streptozocin / Q000009:adverse effects* / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D004149:Dioxoles; D017705:Lignans; D013311:Streptozocin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; C054125:sesamin