title: Synthesis of heteroarylated polyfluorobiphenyls via palladium-catalyzed sequential sp2 C-H bonds functionalizations.
abstract: The higher reactivity of C5-H bonds of heteroarenes as compared to C-H bonds of bromopolyfluorobenzenes for palladium-catalyzed direct arylation allows the selective synthesis of the polyfluoroaryl-heteroarenes in moderate to high yields, without C-H bond functionalization of the polyfluorobenzene ring. In most cases, low loading of Pd(OAc)2 catalyst (0.5-1 mol %) was employed. Then, from these heteroarylated polyfluorobenzenes, the palladium-catalyzed C-H bond functionalization of the polyfluorobenzene ring allows the synthesis of heteroarylated polyfluorobiphenyls.
authors: Institut des Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes Centre of Catalysis and Green Chemistry, Campus de Beaulieu, 35042 Rennes, France.
authors: Tao
authors: T
authors: Yan
authors: Lu
authors: L
authors: Chen
authors: Christian
authors: C
authors: Bruneau
authors: Pierre H
authors: PH
authors: Dixneuf
authors: Henri
authors: H
authors: Doucet