title: BMI change patterns and disability development of middle-aged adults with diabetes: a dual trajectory modeling approach.
abstract: BACKGROUND
  Few longitudinal studies have examined associations between body mass index (BMI) changes in adults with diabetes and the development of disability.
  
  
  OBJECTIVE
  To investigate association patterns between BMI and disability in middle-aged adults with diabetes.
  
  
  METHODS
  Retrospective cohort design with data from the 1992-2006 Health and Retirement Study (HRS). A group-based joint trajectory method identified distinct BMI change trajectories and their link to subsequent disability trajectories.
  
  
  METHODS
  U.S. nationally representative adults aged 51-61 who reported a diagnosis of diabetes in the 1992 HRS (N = 1,064).
  
  
  METHODS
  BMI and self-reported disability score were the main variables. Sociodemographic, clinical, behavioral, and diabetes-related factors were also examined.
  
  
  RESULTS
  Four distinct weight trajectories (stable normal weight, 28.7 %; stable overweight, 46.2 %; loss and regain obese, 18.0 %; weight cumulating morbidly obese, 7.1 %) and three disability trajectories (little or low increase, 34.4 %; moderate increase, 45.4 %; chronic high increase, 20.2 %) best characterized the long-term patterns of BMI and disability change in middle-aged adults with diabetes. Adults in stable normal weight had the highest probability of being in the little/low increase disability group; however, one in five adults in that group progressed into chronic high disability, a higher proportion compared to the stable overweight group.
  
  
  CONCLUSIONS
  Although there were various ways in which the two trajectories were linked, the beneficial impacts of optimizing weight in adults with diabetes were supported. In addition, the complexity of diabetes control in those with relatively normal weight was highlighted from this study.
authors: Institute of Gerontology, College of Medicine, National Cheng Kung University, No. 1, University Road, Tainan, Taiwan 70101. cjchiu@mail.ncku.edu.tw
authors: Ching-Ju
authors: CJ
authors: Chiu
authors: Linda A
authors: LA
authors: Wray
authors: Feng-Hwa
authors: FH
authors: Lu
authors: Elizabeth A
authors: EA
authors: Beverly
mesh_terms: D000203:Activities of Daily Living; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D004185:Disability Evaluation; D006233:Persons with Disabilities / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D009767:Obesity, Morbid / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D050177:Overweight / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology; D015430:Weight Gain / Q000502:physiology; D015431:Weight Loss / Q000502:physiology