title: [Biomaterials and technologies for vascular grafts: from bench to bedside].
abstract: Peripheral artery disease and related revascularization procedures are increasing, due to the aging population and growing incidence of diabetes mellitus. Up to now, autologous saphenous vein is the conduit of choice for peripheral by-pass. Synthetic vascular graft in polyethylene terephthalate (Dacron®) and expanded polytetrafluoroethylene (ePTFE) are used if vein access cannot be obtained. These synthetic grafts are successfully used to replace large diameter vessels, but they fail in small diameters (<6 mm) such as for infragenicular by-pass. Reasons for failure are early thrombosis and late intimal hyperplasia. Novel small-diameter vascular grafts with an acceptable clinical outcome are therefore needed. Here, the main materials and technologies for the manufacturing of vascular grafts and the pathway from bench to bedside are discussed .
authors: Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Massa.
authors: Paola
authors: P
authors: Losi
authors: Enrica
authors: E
authors: Briganti
authors: Marco
authors: M
authors: Vaghetti
authors: Giorgio
authors: G
authors: Soldani
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D002986:Clinical Trials as Topic; D006801:Humans; D006965:Hyperplasia; D020007:Implants, Experimental; D008422:Materials Testing; D023421:Models, Animal; D058729:Peripheral Arterial Disease / Q000601:surgery; D010973:Platelet Adhesiveness; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000209:etiology; D011475:Prosthesis Failure; D013927:Thrombosis / Q000209:etiology; D057170:Translational Research, Biomedical; D017539:Tunica Intima / Q000473:pathology
chemical_list: D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene