title: Is tendinitis an inflammatory disease initiated and driven by pro-inflammatory cytokines such as interleukin 1β?
abstract: Tendonitis and tendinitis are terms used to describe an inflamed and painful tendon. Tendinopathy, is a descriptive term for describing clinical conditions arising from tendon injury and overuse both within and around tendons. The aim of this mini-review is to explore the role of pro-inflammatory cytokines, particularly interleukin-1β (IL-1β) in tendon disorders. A number of investigators including our group have proposed that pro-inflammatory cytokines such as IL-1β are initiators of tendinopathies, stimulating inflammation, apoptosis and extracellular matrix (ECM) degradation. This is one of the reasons why IL-1β is frequently used in culture models of tendon inflammation to study the inflammatory and catabolic responses of tenocytes. However, some researchers oppose this view and suggest that although IL-1β may play a role in rheumatoid arthritis (RA) and osteoarthritis (OA), the involvement of IL-1β in the development of tendinopathy is questionable. This mini-review discusses the relevant papers published in this area and summarises the evidence for and against the involvement of pro-inflammatory cytokines such as IL-1β in tendonitis. Reaching a consensus will be important for the development and refinement of biomimetic models of tendon inflammation and the formulation of new therapeutic strategies for the treatment of tendon injuries.
authors: Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Arthritis Research UK Pain Centre, Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, Leicestershire, United Kingdom. ali.mobasheri@nottingham.ac.uk
authors: A
authors: A
authors: Mobasheri
authors: M
authors: M
authors: Shakibaei
mesh_terms: D000125:Achilles Tendon / Q000473:pathology / Q000648:ultrastructure; D000818:Animals; D017209:Apoptosis; D003094:Collagen / Q000737:chemistry; D016207:Cytokines / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D024841:Fluoroquinolones / Q000737:chemistry; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000503:physiopathology; D053583:Interleukin-1beta / Q000378:metabolism*; D051381:Rats; D052256:Tendinopathy / Q000378:metabolism*; D013710:Tendons / Q000473:pathology
chemical_list: D016207:Cytokines; D024841:Fluoroquinolones; D053583:Interleukin-1beta; D003094:Collagen