title: Lack of increased P15INK4B protein expression in basal cell carcinomas.
abstract: BACKGROUND
  The basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSK). BCC might develop because of the faulty cell cycle arrest. P15INK4b is a tumor suppressor gene, involved in cell cycle arrest and inactivated in most human cancers. The role of p15INK4b protein expression in the genesis of BCC is as yet unknown. In a previous study we showed the absence of p15INK4b expression in the majority of tissue microarray cores of cutaneous squamous cell carcinoma (SCCs), another type of non-melanoma skin cancer, indicating that p15INK4b could possibly be involved in the pathogenesis of cutaneous SCC. The aim of this study was to investigate p15INK4b protein expression in BCCs.
  
  
  METHODS
  Protein expression of p15INK4b in 35 cases of BCC tissue arrays and 19 cases of normal human skin tissue was studied using an immunohistochemical approach.
  
  
  RESULTS
  The expression of p15INK4b was not significantly different in the BCC cases as compared with normal human skin (p=0.356; p>0.05). In addition, there were no significant relationship between clinicopathologic variables of patients (age and sex) and p15INK4b protein expression.
  
  
  CONCLUSIONS
  Our finding may indicate that p15INK4b protein expression does not play a role in the genesis of BCC.
authors: Advanced Medical and Dental Institute, University Sains Malaysia, Penang, Malaysia. mohamed.mabruk@.ubd.edu.bn
authors: Ahmed Ismail Hassan
authors: AI
authors: Moad
authors: Mei Lan
authors: ML
authors: Tan
authors: Gurjeet
authors: G
authors: Kaur
authors: Mohamed
authors: M
authors: Mabruk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000378:metabolism; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism*; D055815:Young Adult
chemical_list: D050762:Cyclin-Dependent Kinase Inhibitor p15