title: [Interleukin-1-mediated diseases].
abstract: Interleukin-1 (IL-1)-mediated diseases are caused by an inappropriately high production and release of IL-1 beta which results in a multitude of symptoms, e.g. arthritis, exanthema, conjunctivitis, serositis, fever and loss of hearing. If IL-1-mediated diseases remain unrecognized or are recognized and treated too late, long-term complications, such as amyloidosis may occur. In recent years the diagnostic and therapeutic options with respect to IL-1-mediated diseases have drastically improved. These diseases often manifesting in childhood can now be treated with monoclonal antibodies against IL-1 or with IL-1 receptor antagonists. Increased IL-1 secretion does not only play a role in relatively rare hereditary diseases, such as cryopyrin-associated periodic fever syndromes or familial Mediterranean fever but also in widespread diseases, such as gout or type 2 diabetes. This article will focus on pathogenic, diagnostic and therapeutic aspects of IL-1-mediated inflammatory diseases.
authors: Institut für Immunologie, Universitätsklinikum Münster, Münster.
authors: D
authors: D
authors: Holzinger
authors: H
authors: H
authors: Becker
authors: A M
authors: AM
authors: Jacobi
mesh_terms: D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology*; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy*
chemical_list: D058847:Inflammasomes; D007375:Interleukin-1