title: Interactions between oxidative stress, lipid profile and antioxidants in breast cancer: a case control study.
abstract: Oxidant/antioxidant balance has been suggested as an important factor for initiation and progression of cancer. The objective of this study was to determine changes in the levels of malondialdehyde (MDA), nitric oxide (NO), total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, total antioxidant capacity (TAC), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities in serum samples of breast cancer patients (n=30) and healthy subjects (n=100). MDA and NO levels were found to be increased in breast cancer patients compared to the healthy subject group (p<0.05). Total cholesterol and triglycerides were elevated; and HDL- cholesterol level was found to be decreased in the cancer patients as compared to the healthy subjects (p<0.05). Compared to the healthy group, both serum TAC levels (p<0.001) and activity of SOD and GSH-Px (p=0.05) were found to be decreased in the breast cancer patients as compared to the healthy controls. Considering the data presented in this study, we suggest that free radicals induce lipid eroxidation and peroxidation of unsaturated fatty acid with decreased activity of enzymatic antioxidants in breast cancer.
authors: Department of Biochemistry, National Medical College, Birgunj, Nepal. rax_goupta@yahoo.com
authors: Rakesh Kumar
authors: RK
authors: Gupta
authors: Amit Kumar
authors: AK
authors: Patel
authors: Rajni
authors: R
authors: Kumari
authors: Seema
authors: S
authors: Chugh
authors: Chitrangada
authors: C
authors: Shrivastav
authors: Siddharth
authors: S
authors: Mehra
authors: Ajay Narayan
authors: AN
authors: Sharma
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000503:physiopathology*; D016022:Case-Control Studies; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D009569:Nitric Oxide; D008315:Malondialdehyde; D002784:Cholesterol; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase