title: Coronary endothelial dysfunction demonstrated by means of (15)O-labeled water PET/CT in hypothyroid cardiomyopathy.
abstract: Hypothyroidism is a rare cause of dilated cardiomyopathy. Triiodothyronine was found to target endothelial nitric oxide synthase, which serves to enhance peripheral vascular relaxation by acting on vascular smooth muscle cells. In patients with subclinical hypothyroidism, adenosine-induced coronary flow reserve is significantly reduced. We report the case of a 46-year-old woman with hypothyroid cardiomyopathy manifested as reversible severe left ventricular dysfunction (LVEF = 32%). O-labeled water PET at rest and during cold pressor test showed a severe coronary endothelial dysfunction. In patients with severe hypothyroidism, endothelial function is impaired and may be an important mechanism of heart failure.
authors: Nuclear Medicine Department, CHU de Caen, Caen, France. damien.legallois@gmail.com
authors: Damien
authors: D
authors: Legallois
authors: Juliette
authors: J
authors: Hardouin
authors: Denis
authors: D
authors: Agostini
authors: Paul
authors: P
authors: Milliez
authors: Alain
authors: A
authors: Manrique
mesh_terms: D009202:Cardiomyopathies / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008875:Middle Aged; D064847:Multimodal Imaging; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014867:Water
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water