title: Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones.
abstract: A series of pyrazinones were prepared and evaluated as potential CRF(1)R PET imaging agents. Optimization of their CRF(1)R binding potencies and octanol-phosphate buffer phase distribution coefficients are discussed herein.
authors: Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. derek.denhart@bms.com
authors: Derek J
authors: DJ
authors: Denhart
authors: Dmitry
authors: D
authors: Zuev
authors: Jonathan L
authors: JL
authors: Ditta
authors: Richard A
authors: RA
authors: Hartz
authors: Vijay T
authors: VT
authors: Ahuja
authors: Ronald J
authors: RJ
authors: Mattson
authors: Hong
authors: H
authors: Huang
authors: Gail K
authors: GK
authors: Mattson
authors: Larisa
authors: L
authors: Zueva
authors: Julia M
authors: JM
authors: Nielsen
authors: Edward S
authors: ES
authors: Kozlowski
authors: Nicholas J
authors: NJ
authors: Lodge
authors: Joanne J
authors: JJ
authors: Bronson
authors: John E
authors: JE
authors: Macor
mesh_terms: D000818:Animals; D001921:Brain; D006801:Humans; D015394:Molecular Structure; D049268:Positron-Emission Tomography; D011719:Pyrazines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000737:chemistry; D000099052:CRF Receptor, Type 1
chemical_list: D011719:Pyrazines; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1