title: NLRP3 inflammasomes show high expression in aorta of patients with atherosclerosis.
abstract: OBJECTIVE
  The aim of the present study was to investigate the expression of NLRP3 in aorta of patients with coronary atherosclerosis and to explore the association between aortic expression levels of NLRP3 and atherosclerotic risk factors.
  
  
  METHODS
  We collected small pieces of ascending aorta from 36 patients undergoing coronary artery bypass graft (CABG) surgery, and the arterial tissues from 10 subjects without atherosclerosis through the kidney donation program were taken as control. The expression of NLRP3 of the research and control group was determined by immunohistochemistry. Gensini score was used to evaluate the severity of coronary atherosclerosis.
  
  
  RESULTS
  NLRP3 was strongly expressed in aorta of CABG patients. The aortic NLRP3 expression was elevated in patients with hypertension or diabetes, and smokers. The NLRP3 expression in aorta was positively correlated with total cholesterol, low density lipoprotein cholesterol, and lipoprotein(a) (P<0.05); but negatively correlated with high density lipoprotein cholesterol (P<0.05). Spearman correlation revealed that aortic NLRP3 expression had significant correlation with Gensini coronary severity scores (P<0.05).
  
  
  CONCLUSIONS
  NLRP3 was overexpressed in aorta of patients with coronary atherosclerosis and the aortic NLRP3 expression is correlated with the severity of coronary artery disease and the atherosclerotic risk factors.
authors: Department of Cardiology, Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, PR China.
authors: Fei
authors: F
authors: Zheng
authors: Shanshan
authors: S
authors: Xing
authors: Zushun
authors: Z
authors: Gong
authors: Qichong
authors: Q
authors: Xing
mesh_terms: D000368:Aged; D001011:Aorta / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002352:Carrier Proteins / Q000096:biosynthesis*; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D058847:Inflammasomes / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human
keywords: Atherosclerosis; Coronary artery bypass graft; Inflammation; NLRP3; Risk factors