title: Gaze-evoked amaurosis from orbital breast carcinoma metastasis.
abstract: Gaze-evoked amaurosis (GEA) is a transient monocular vision loss provoked by eccentric gaze. Gaze-evoked amaurosis has been associated with a variety of orbital lesions, most commonly optic nerve sheath meningiomas and cavernous hemangiomas. The authors describe the first report in the literature of GEA as the presenting symptom of an orbital metastasis. The patient was a 47-year-old woman with a history of breast cancer with no known history of metastasis or active disease who presented with several weeks of vision loss in the OD upon rightward gaze. She was found to have enophthalmos and optic disc edema of the OD. Imaging revealed an intraorbital lesion, and a biopsy was consistent with a scirrhous metastasis of her breast carcinoma. This case highlights the importance of considering orbital metastases among the differential for gaze-evoked amaurosis.
authors: Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors: Mrinali M
authors: MM
authors: Patel
authors: Daniel R
authors: DR
authors: Lefebvre
authors: N Grace
authors: NG
authors: Lee
authors: Elena
authors: E
authors: Brachtel
authors: Joseph
authors: J
authors: Rizzo
authors: Suzanne K
authors: SK
authors: Freitag
mesh_terms: D001766:Blindness / Q000209:etiology*; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000556:secondary*