title: Endodermal stem cell populations derived from pluripotent stem cells.
abstract: The generation of functional endodermal lineages, such as hepatocytes and pancreatic endocrine cells, from pluripotent stem cells (PSCs) remains a challenge. One strategy to enhance the purity, yield and maturity of endodermal derivatives is to expand endoderm committed stem or progenitor cell populations derived from PSCs before final differentiation. Recent studies have shown that this is in fact a viable option both for expanding pure populations of endodermal cells as well as for generating more mature derivative tissues, as highlighted in the case of pancreatic beta cells.
authors: Center for Cellular and Molecular Therapeutics, and Department of Pathology & Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
authors: Xin
authors: X
authors: Cheng
authors: Amita
authors: A
authors: Tiyaboonchai
authors: Paul
authors: P
authors: Gadue
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D065150:Cellular Reprogramming; D004707:Endoderm / Q000166:cytology*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology; D039904:Pluripotent Stem Cells / Q000166:cytology*