title: Extremely low-frequency magnetic field induces manganese accumulation in brain, kidney and liver of rats.
abstract: The aim of the present study was to determine the effects of extremely low-frequency magnetic field (ELF-MF) on accumulation of manganese (Mn) in the kidney, liver and brain of rats. A total of 40 rats were randomly divided into eight groups. Four control groups received 0, 3.75, 15 and 60 mg Mn per kg body weight orally every 2 days for 45 days, respectively. The remaining four groups received same concentrations of Mn and were also exposed to ELF-MF (1.5 mT; 50 Hz) for 4 h for 5 days a week during 45 days. Following the last exposure, kidney, liver and brain were taken from all rats and they were analyzed for Mn accumulation levels using an inductively coupled plasma-optical emission spectrometer. In result of the current study, we observed that Mn levels in brain, kidney and liver were higher in Mn groups than in control groups. Mn levels in brain, kidney and liver were also higher in Mn plus ELF-MF groups than in Mn groups. In conclusion, result of the current study showed that the ELF-MF induced manganese accumulation in kidney, liver and brain of rats.
authors: Department of Biophysics, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Mustafa Salih
authors: MS
authors: Çelik
authors: Department of Biology, Faculty of Science, Dicle University, Diyarbakir, Turkey.
authors: Kemal
authors: K
authors: Güven
authors: Department of Biophysics, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Veysi
authors: V
authors: Akpolat
authors: Department of Biophysics, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: Mehmet Zulkuf
authors: MZ
authors: Akdağ
authors: Department of Biophysics, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey mustafanaziroglu@sdu.edu.tr.
authors: Mustafa
authors: M
authors: Nazıroğlu
authors: Science Teaching Program, Primary Education Department, Faculty of Ziya Gokalp Education, Diyarbakir, Turkey.
authors: Reyhan
authors: R
authors: Gül-Güven
authors: Department of Biostatics, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors: M Yusuf
authors: MY
authors: Çelik
authors: Department of Chemistry, Faculty of Science, Dicle University, Diyarbakir, Turkey.
authors: Sait
authors: S
authors: Erdoğan
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004311:Double-Blind Method; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D060526:Magnetic Fields / Q000009:adverse effects*; D008297:Male; D008345:Manganese / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008345:Manganese
keywords: Manganese; brain; electromagnetic field; kidney; liver; rat