title: Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice.
abstract: Dietary restriction is a powerful aging intervention that extends the life span of diverse biological species ranging from yeast to invertebrates to mammals, and it has been argued that the antiaging action of dietary restriction occurs through reduced oxidative stress/damage. Using Sod1(-/-) mice, which have previously been shown to have increased levels of oxidative stress associated with a shorter life span and a high incidence of neoplasia, we were able to test directly the ability of dietary restriction to reverse an aging phenotype due to increased oxidative stress/damage. We found that dietary restriction increased the life span of Sod1(-/-) mice 30%, returning it to that of wild-type, control mice fed ad libitum. Oxidative damage in Sod1(-/-) mice was markedly reduced by dietary restriction, as indicated by a reduction in liver and brain F2-isoprostanes, a marker of lipid peroxidation. Analysis of end of life pathology showed that dietary restriction significantly reduced the overall incidence of pathological lesions in the Sod1(-/-) mice fed the dietary-restricted diet compared to Sod1(-/-) mice fed ad libitum, including the incidence of lymphoma (27 vs 5%) and overall liver pathology. In addition to reduced incidence of overall and liver-specific pathology, the burden and severity of both neoplastic and nonneoplastic lesions was also significantly reduced in the Sod1(-/-) mice fed the dietary-restricted diet. These data demonstrate that dietary restriction can significantly attenuate the accelerated aging phenotype observed in Sod1(-/-) mice that arises from increased oxidative stress/damage.
authors: Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, TX 78229-3900, USA.
authors: Yiqiang
authors: Y
authors: Zhang
authors: Yuji
authors: Y
authors: Ikeno
authors: Alex
authors: A
authors: Bokov
authors: Jon
authors: J
authors: Gelfond
authors: Carlos
authors: C
authors: Jaramillo
authors: Hong-Mei
authors: HM
authors: Zhang
authors: Yuhong
authors: Y
authors: Liu
authors: Wenbo
authors: W
authors: Qi
authors: Gene
authors: G
authors: Hubbard
authors: Arlan
authors: A
authors: Richardson
authors: Holly
authors: H
authors: Van Remmen
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001921:Brain / Q000378:metabolism; D004032:Diet; D028441:F2-Isoprostanes / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D000072105:Superoxide Dismutase-1
chemical_list: D028441:F2-Isoprostanes; C000606290:SOD1 protein, human; C000606291:Sod1 protein, mouse; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1