title: Eosinophilic esophagitis.
abstract: Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition whereby infiltration of eosinophils into the esophageal mucosa leads to symptoms of esophageal dysfunction. EoE is encountered in a substantial proportion of patients undergoing diagnostic upper endoscopy. This review discusses the clinical, endoscopic, and histologic features of EoE and presents the most recent guidelines for its diagnosis. Selected diagnostic dilemmas are described, including distinguishing EoE from gastroesophageal reflux disease and addressing the newly recognized clinical entity of proton-pump inhibitor-responsive esophageal eosinophilia. Also highlighted is evidence to support both pharmacologic and nonpharmacologic treatments, including topical corticosteroids, dietary elimination therapy, and endoscopic dilation.
authors: Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, CB#7080, Bioinformatics Building, 130 Mason Farm Road, UNC-CH, Chapel Hill, NC 27599-7080, USA. edellon@med.unc.edu
authors: Evan S
authors: ES
authors: Dellon
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D004035:Diet Therapy; D004106:Dilatation; D057765:Eosinophilic Esophagitis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D004945:Esophagoscopy; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D015848:Interleukin-5 / Q000037:antagonists & inhibitors
chemical_list: D000305:Adrenal Cortex Hormones; D061067:Antibodies, Monoclonal, Humanized; D007155:Immunologic Factors; D015848:Interleukin-5; C515492:reslizumab; C434107:mepolizumab