title: [Roles of aberrant endothelial progenitor cells in pathogenesis of systemic sclerosis].
abstract: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by excessive fibrosis and microvasculopathy, along with poor vascular formation and repair. The maintenance of the postnatal vascular system requires constant remodeling through vasculogenesis, which is mediated by the de novo differentiation of mature endothelial cells from endothelial progenitor cells (EPCs). However, a great deal of controversy about EPCs and their roles in postnatal vascular formation has arisen because of discrepancies in how EPCs are defined. The current consensus is that EPCs are heterogeneous cell population containing an extremely small count of "true EPCs", and pro-angiogenic hematopoietic cells (PHCs) that promotes vascular formation and repair through secretion of pro-angiogenic factors, and differentiation into endothelial cells and mural cells. In 2004, we reported a reduced number and impaired function of circulating CD34(+)CD133(+)CD309(+)CD45(dim)CD14(-) EPCs, which are now regarded as an immature subset of PHCs, in patients with SSc, and proposed a theory that defective vascular repair machinery as one of important mechanisms contributing to SSc vasculopathy. In addition, we showed that in SSc patients, circulating monocytic PHCs were increased and have enhanced angiogenic potency and differentiation potential to fibroblast-like cells. In summary, EPCs are involved in the pathogenesis of SSc by participating in two major pathological features, microvasculopathy and excessive fibrosis. Understanding the roles of EPCs in disease process of SSc may be key to dissecting its pathogenesis and to developing novel therapeutic strategies for this intractable condition.
authors: Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine.
authors: Masataka
authors: M
authors: Kuwana
mesh_terms: D043925:Angiogenesis Inducing Agents; D001854:Bone Marrow Cells / Q000166:cytology / Q000473:pathology* / Q000502:physiology*; D002454:Cell Differentiation; D042783:Endothelial Cells / Q000166:cytology / Q000473:pathology* / Q000502:physiology*; D005355:Fibrosis; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000473:pathology; D006801:Humans; D009389:Neovascularization, Pathologic; D012595:Scleroderma, Systemic / Q000209:etiology* / Q000473:pathology*
chemical_list: D043925:Angiogenesis Inducing Agents