title: Influence of treatment with quercetin on lipid parameters and oxidative stress of pregnant diabetic rats.
abstract: Among the numerous coadjuvant therapies that could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials. We investigated the effect of quercetin on biochemical parameters in streptozotocin-induced (60 mg/kg body mass, by intraperitoneal injection) diabetic rats. A total of 32 female Wistar rats were distributed among 4 groups as follows: control (G1); control treated with quercetin (G2); diabetic (G3); and diabetic treated with quercetin (G4). Quercetin administered to pregnant diabetic rats controlled dyslipidemia and improved lipid profiles in diabetes mellitus, regulated oxidative stress by reducing the generation of lipid hydroperoxides, and increased the activity of the antioxidant enzyme glutathione peroxidase.
authors: Departamento de Química e Bioquímica, Instituto de Biociências, Campus de Botucatu, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, 18618-970, Botucatu, São Paulo, Brazil. braga_ca@ibb.unesp.br
authors: Camila
authors: C
authors: Pereira Braga
authors: Ana Carolina
authors: AC
authors: Momentti
authors: Fernando
authors: F
authors: Barbosa Peixoto
authors: Rafaela
authors: R
authors: de Fátima Ferreira Baptista
authors: Felipe André
authors: FA
authors: dos Santos
authors: Fábio Henrique
authors: FH
authors: Fava
authors: Ana Angélica Henrique
authors: AA
authors: Fernandes
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008054:Lipid Peroxides; D008055:Lipids; D011794:Quercetin; D005979:Glutathione Peroxidase