title: Relationship between the degeneration of the cruciate ligaments and calcium pyrophosphate dihydrate crystal deposition: anatomic, radiologic study with histologic correlation.
abstract: To investigate the association of calcium pyrophosphate dihydrate (CPPD) crystal deposition and cruciate ligament (CL) degeneration, 10 cadaveric knees were studied with 1.5-T magnetic resonance imaging and sectioned in three planes. The slices were evaluated with high-resolution Faxitron radiography. The images and specimens were evaluated by two radiologists. Histologic sections were obtained from eight that contained calcifications and from two without calcifications. Radiographs and histologic analysis demonstrated CPPD crystal deposition in 80% of specimens and 75% of CLs in these eight specimens. Degenerative changes were observed in 75% of them. Such analysis demonstrated no evidence of CPPD crystals or degeneration in the control specimens.
authors: Department of Radiology, University of California, San Diego, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. bernadirim@gmail.com
authors: Berna
authors: B
authors: Dirim
authors: Donald
authors: D
authors: Resnick
authors: Marcelo
authors: M
authors: Abreu
authors: Mani
authors: M
authors: Wangwinyuvirat
authors: Debra J
authors: DJ
authors: Trudell
authors: Parviz
authors: P
authors: Haghighi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016118:Anterior Cruciate Ligament / Q000473:pathology*; D002102:Cadaver; D002805:Chondrocalcinosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D016119:Posterior Cruciate Ligament / Q000473:pathology*; D013194:Staining and Labeling