title: Brain metastases from colorectal cancer: microenvironment and molecular mechanisms.
abstract: Colorectal cancer is one of the most common digestive tract malignancies in the world. Owing to the newer and more effective systemic therapies, the life of colorectal cancer patients can be remarkably prolonged, and the incidence of brain metastases is increasing. However, little is known about the underlying mechanisms of brain metastasis from colorectal cancer. Here we review the tumor microenvironment and metastasis associated molecules in brain metastases from colorectal cancer. A further understanding of these mechanisms will help us to propose better strategies for colorectal cancer patients with brain metastasis and improve their life quality.
authors: Department of General Surgery, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai 200040, China. zongyouc@sohu.com.
authors: Yi-Wen
authors: YW
authors: Zang
authors: Xiao-Dong
authors: XD
authors: Gu
authors: Jian-Bin
authors: JB
authors: Xiang
authors: Zong-You
authors: ZY
authors: Chen
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary / Q000628:therapy; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D006801:Humans; D009362:Neoplasm Metastasis; D059016:Tumor Microenvironment