title: The prognostic significance of molecular subtype for male breast cancer: a 10-year retrospective study.
abstract: BACKGROUND
  Male breast cancer (MBC) is rare. Molecular subtype has been utilized widely in female breast cancer. But the relationship between subtype and prognosis in MBC patients is still unknown. We aim to study the impact of molecular subtype on the prognosis of MBC.
  
  
  METHODS
  We identified MBC cases from 1990 to 2011 retrospectively; molecular subtype was assigned by immunohistochemistry. We compared overall survival in different subtypes by Kaplan-Meier method and COX proportional hazard regression model.
  
  
  RESULTS
  68 patients with MBC were included in analysis with 115 months of a median follow-up time. Comparing to non-luminal A (subtypes of Luminal B, HER2 over-express and Basal-like) group, patients with luminal A had a lower recurrent rate and better overall survival (10-year survival rate was 78.0% vs 67.0%, mean survival time 197.46 ± 12.22 months vs 146.51 ± 16.88 months, p < 0.05).
  
  
  CONCLUSIONS
  Molecular subtype may have prognosis-predicting value for MBC.
authors: Department of Breast Tumor Surgery, Zhejiang Cancer Hospital, 38# Guangji Lu, Banshan Qiao, Hangzhou, Zhejiang Province 310022, PR China. Electronic address: yxfecho@yahoo.com.cn.
authors: Xing-Fei
authors: XF
authors: Yu
authors: Wei-Liang
authors: WL
authors: Feng
authors: Lu-Lu
authors: LL
authors: Miao
authors: Bo
authors: B
authors: Chen
authors: Hong-Jian
authors: HJ
authors: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018567:Breast Neoplasms, Male / Q000737:chemistry* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry* / Q000556:secondary; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000737:chemistry*; D011379:Prognosis; D016016:Proportional Hazards Models; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human
keywords: DCIS; ER; Epidermal growth factor receptor 2; FISH; HER2; IDC; IHC; MBC; Male breast cancer; Molecular subtypes; Overall survival; PR; Prognosis; ductal carcinoma in situ; estrogen receptor; fluorescence in situ by hybridization; immuno histochemical method; invasive ductal carcinoma; male breast cancer; progesterone