title: Prognostic value of neuron specific enolase and IL-10 in ischemic stroke and its correlation with degree of neurological deficit.
abstract: BACKGROUND
  The blood-brain barrier is compromised in stroke patients. The release of neuro-biochemical protein markers, such as Neuron Specific Enolase (NSE) into the circulation may allow the pathophysiology and prognosis of patients with cerebrovascular diseases to be evaluated further.
  
  
  METHODS
  Present study aimed to investigate the predictive value of NSE and Interleukin-10 (IL-10) with respect to early neurobehavioral outcome which evaluated by National Institute of Health Stroke Scale (NIHSS). We investigated 100 patients of ischemic stroke and blood samples were taken within first 72 h of stroke onset. NSE and IL-10 were analyzed by commercially available ELISA kits. The neurological status was evaluated by a standardized NIHSS at the time of admission.
  
  
  RESULTS
  NSE was significantly increased (17.95±4.54 vs 7.48±1.51 {ng/ml} p≤0.05) and IL-10 significantly decreased (11.79±2.77 vs 15.72±2.69 {pg/ml} p≤0.05) in patients when compared with controls. NSE also significantly (r=0.8, p≤0.001) correlated with degree of neurological deficit but IL-10 level in serum did not show any significant correlation with NIHSS score at the time of admission.
  
  
  CONCLUSIONS
  Serum concentrations of NSE and IL-10 have a high predictive value for early neurobehavioral outcome after acute stroke.
authors: Department of Pathology, Hindu Rao Hospital, Delhi, India.
authors: Harsh Vardhan
authors: HV
authors: Singh
authors: Aparna
authors: A
authors: Pandey
authors: Amit Kumar
authors: AK
authors: Shrivastava
authors: Arun
authors: A
authors: Raizada
authors: Sanjeev Kumar
authors: SK
authors: Singh
authors: Neelima
authors: N
authors: Singh
mesh_terms: D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology / Q000503:physiopathology*
chemical_list: D016753:Interleukin-10; D010751:Phosphopyruvate Hydratase