title: Facile synthesis of magnetite/perfluorocarbon co-loaded organic/inorganic hybrid vesicles for dual-modality ultrasound/magnetic resonance imaging and imaging-guided high-intensity focused ultrasound ablation.
abstract: Multifunctional organic/inorganic hybrid nanovesicles, fabricated by a facile self-assembly/sol-gel approach, display a unique morphology (figure) and satisfactory stability under physiological conditions. By co-encapsulation of superparamagnetic magnetite nanoparticles and a liquid perfluorocarbon, the nanovesicles can be used not only as a dual-modality ultrasound/magnetic resonance contrast agent for accurate cancer diagnosis and monitoring, but also as a therapeutic enhancement agent for effective high-intensity focused ultrasound (HIFU) ablation.
authors: Laboratory of Low-Dimensional Materials Chemistry, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, PR China.
authors: Dechao
authors: D
authors: Niu
authors: Xia
authors: X
authors: Wang
authors: Yongsheng
authors: Y
authors: Li
authors: Yuanyi
authors: Y
authors: Zheng
authors: Faqi
authors: F
authors: Li
authors: Hangrong
authors: H
authors: Chen
authors: Jinlou
authors: J
authors: Gu
authors: Wenru
authors: W
authors: Zhao
authors: Jianlin
authors: J
authors: Shi
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis; D005466:Fluorocarbons / Q000627:therapeutic use*; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry / Q000627:therapeutic use; D010316:Particle Size; D025321:Surgery, Computer-Assisted / Q000379:methods; D014463:Ultrasonography / Q000379:methods*
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; D058185:Magnetite Nanoparticles; D053769:Nanocapsules