title: A rare case of myocardial infarction related to diagnostic intravascular ultrasound.
abstract: A 71-year-old man underwent intracoronary stent implantation for acute inferior myocardial infarction (MI). Immediately after diagnostic intravascular ultrasound (IVUS) at 8 months' follow-up, an acute occlusion of the sinus node (SN) artery appeared, which developed sinus arrest with junctional escape rhythm. The serum level of high-sensitivity troponin T (TpT) was markedly elevated on the day after the procedure (2.1-32.5 ng/l), which was indicative of MI related to IVUS. Under continuous intravenous infusion of unfractionated heparin, the escape rhythm changed to lower atrial rhythm on the 4th day, and recovered to sinus rhythm on the 14th day. Coronary angiography (CAG) on 15th day showed a recanalization of the SN artery, but optical coherence tomography identified that disrupted plaque and white thrombus still existed in the ostium of the SN artery. The patient was discharged on maintenance anticoagulation therapy. We hypothesized from this case that IVUS-related myocardial injury may exist without clinical problems. Our retrospective investigation showed that the median levels of high-sensitivity TpT in 20 patients who underwent CAG and subsequent diagnostic IVUS significantly increased from 0.6 (interquartile range 0.3-1.1) to 1.6 (0.7-3.6) ng/l (P < 0.05), suggesting that IVUS may induce very low levels of myocardial injury. In conclusion, we experienced a rare case of IVUS-related MI caused by an acute occlusion of the SN artery. This case reaffirms that we should pay more attention to manipulation of IVUS catheters.
authors: Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
authors: Ken
authors: K
authors: Otsuji
authors: Fumihiko
authors: F
authors: Kamezaki
authors: Shinjo
authors: S
authors: Sonoda
authors: Kuninobu
authors: K
authors: Kashiyama
authors: Yoshitaka
authors: Y
authors: Muraoka
authors: Yuki
authors: Y
authors: Tsuda
authors: Masaru
authors: M
authors: Araki
authors: Masahiro
authors: M
authors: Okazaki
authors: Masaaki
authors: M
authors: Takeuchi
authors: Yutaka
authors: Y
authors: Otsuji
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D054059:Coronary Occlusion / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003328:Coronary Thrombosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004562:Electrocardiography; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D056989:Inferior Wall Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D020107:Troponin T / Q000097:blood; D018084:Ultrasonography, Interventional / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D015415:Biomarkers; D020107:Troponin T; D006493:Heparin