title: Clinical relevance of the ESKAPE pathogens.
abstract: In recent years, the Infectious Diseases Society of America has highlighted a faction of antibiotic-resistant bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) - acronymically dubbed 'the ESKAPE pathogens' - capable of 'escaping' the biocidal action of antibiotics and mutually representing new paradigms in pathogenesis, transmission and resistance. This review aims to consolidate clinically relevant background information on the ESKAPE pathogens and provide a contemporary summary of bacterial resistance, alongside pertinent microbiological considerations necessary to face the mounting threat of antimicrobial resistance.
authors: School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK.
authors: Jack N
authors: JN
authors: Pendleton
authors: Sean P
authors: SP
authors: Gorman
authors: Brendan F
authors: BF
authors: Gilmore
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology* / Q000503:physiopathology* / Q000635:transmission; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology* / Q000635:transmission*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects* / Q000472:pathogenicity; D006095:Gram-Positive Cocci / Q000145:classification / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents