title: Genetics of impulsive behaviour.
abstract: Impulsivity, defined as the tendency to act without foresight, comprises a multitude of constructs and is associated with a variety of psychiatric disorders. Dissecting different aspects of impulsive behaviour and relating these to specific neurobiological circuits would improve our understanding of the etiology of complex behaviours for which impulsivity is key, and advance genetic studies in this behavioural domain. In this review, we will discuss the heritability of some impulsivity constructs and their possible use as endophenotypes (heritable, disease-associated intermediate phenotypes). Several functional genetic variants associated with impulsive behaviour have been identified by the candidate gene approach and re-sequencing, and whole genome strategies can be implemented for discovery of novel rare and common alleles influencing impulsivity. Via deep sequencing an uncommon HTR2B stop codon, common in one population, was discovered, with implications for understanding impulsive behaviour in both humans and rodents and for future gene discovery.
authors: Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA. laura.bevilacqua@nyumc.org
authors: Laura
authors: L
authors: Bevilacqua
authors: David
authors: D
authors: Goldman
mesh_terms: D000483:Alleles; D000818:Animals; D001288:Attention / Q000187:drug effects; D018388:Codon, Terminator; D003071:Cognition / Q000187:drug effects; D018740:Genetic Heterogeneity; D005838:Genotype; D006801:Humans; D007175:Impulsive Behavior / Q000201:enzymology / Q000235:genetics*; D040582:Inheritance Patterns; D051379:Mice; D018345:Mice, Knockout; D008995:Monoamine Oxidase / Q000235:genetics / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000009:adverse effects; D044403:Receptor, Serotonin, 5-HT2B / Q000235:genetics; D012309:Risk-Taking; D012701:Serotonin / Q000235:genetics / Q000378:metabolism
chemical_list: D018388:Codon, Terminator; D018377:Neurotransmitter Agents; D044403:Receptor, Serotonin, 5-HT2B; D012701:Serotonin; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human