title: MMP1 rs1799750 single nucleotide polymorphism and lung cancer risk: a meta-analysis.
abstract: BACKGROUND
  Numerous studies have investigated the association of matrix metalloproteinase 1 (MMP1) rs1799750 single nucleotide polymorphism with lung cancer susceptibility, but the findings are inconsistent. Therefore, we performed a meta-analysis to comprehensively evaluate any possible association.
  
  
  METHODS
  We searched publications from MEDLINE, EMBASE and CNKI databases which assessed links between the MMP1 rs1799750 polymorphism and lung cancer risk. We calculated the pooled odds ratio (OR) and its 95% confidence interval (95%CI) using either fixed-effects or random-effects models.
  
  
  RESULTS
  The meta-analysis was based on 9 publications encompassing 4,823 cases and 4,298 controls. The overall results suggested there was a significant association between the MMP1 rs1799750 polymorphism and lung cancer risk (1G vs. 2G: OR = 0.83, 95%CI = 0.73-0.94; 1G1G vs. 2G2G: OR = 0.73, 95%CI = 0.59-0.92; 1G1G vs. 1G2G/2G2G: OR = 0.87, 95%CI = 0.79-0.97; 1G1G/1G2G vs. 2G2G: OR = 0.78, 95%CI = 0.64-0.95). In the subgroup analysis by ethnicity, the association was still obvious in Asians (all P values < 0.05), but there was no association in Caucasians (all P values > 0.05).
  
  
  CONCLUSIONS
  The MMP1 rs1799750 polymorphism is associated with decreased lung cancer risk, and a race-specific effect may exist in this association.
authors: Department of Oncology, Taihe Hospital Affiliated with Hubei University of Medicine, Shiyan, China. camelwhite@yahoo.cn
authors: Jiang
authors: J
authors: Hu
authors: Jun
authors: J
authors: Pan
authors: Zhi-Guo
authors: ZG
authors: Luo
mesh_terms: D044466:Asian People; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012307:Risk Factors