title: Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats.
abstract: Increasing evidence has demonstrated that excess fructose consumption as a risk factor for metabolic syndrome causes hyperuricaemia and renal injury. Curcumin, a natural plant phenolic food additive, lowered serum urate, creatinine and blood urea nitrogen levels, and increased urinary urate and nitrate/nitrites levels, as well as renal nitric oxide (NO) production in fructose-fed rats. Moreover, curcumin regulated urate transport-related proteins and inhibited activation of the JAK2-STAT3 cascade and overexpression of SOCS3 and TGF-β1 in the kidneys of fructose-fed rats. These results suggested that the anti-hyperuricaemic and renal protective actions of curcumin might be the result of renal NO-mediated JAK2-STAT3 signalling and TGF-β1 normality, which ameliorated renal endothelial dysfunction to improve renal urate transporter system in this model. The present study may provide the evidence for the potential use of a functional food ingredient curcumin because of its action against hyperuricaemia and renal injury induced by high fructose intake.
authors: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China.
authors: Dong-Mei
authors: DM
authors: Zhang
authors: Yu-Cheng
authors: YC
authors: Li
authors: De
authors: D
authors: Xu
authors: Xiao-Qin
authors: XQ
authors: Ding
authors: Ling-Dong
authors: LD
authors: Kong
mesh_terms: D000818:Animals; D003474:Curcumin / Q000008:administration & dosage*; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism*; D005632:Fructose / Q000009:adverse effects; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D053614:Janus Kinase 2 / Q000235:genetics / Q000378:metabolism*; D007668:Kidney / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D010936:Plant Extracts / Q000008:administration & dosage*; D020011:Protective Agents / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D050796:STAT3 Transcription Factor; D053773:Transforming Growth Factor beta1; D005632:Fructose; D009569:Nitric Oxide; D053614:Janus Kinase 2; D003474:Curcumin