title: The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer.
abstract: The impact of alcohol on the risk of stomach cancer is controversial. Although aldehyde dehydrogenase 2 (ALDH2) Glu504Lys (rs671) polymorphism has a strong effect on acetaldehyde metabolism, little is known about its impact on stomach cancer risk when combined with alcohol drinking. This case-control study included a total of 697 incident stomach cancer case subjects and 1372 non-cancer control subjects who visited Aichi Cancer Center between 2001 and 2005. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ALDH2 genotypes and alcohol consumption using logistic regression models after adjustment for potential confounders, including Helicobacter pylori infection. The ALDH2 504Lys allele was associated with the risk of stomach cancer, with adjusted ORs of 1.40 (95% CI, 1.11-1.76) for Glu/Lys and 1.73 (1.12-2.68) for Lys/Lys compared with Glu/Glu. Heavy drinking was associated with risk (OR 1.72, 1.17-2.52) after adjustment for ALDH2 genotype and other confounders. Moreover, ORs for heavy drinking were 1.28 (0.77-2.12) for those with ALDH2 Glu/Glu and 3.93 (1.99-5.79) for those with the ALDH2 Lys allele relative to non-drinkers with the Glu/Glu genotype (P for interaction = 0.0054). In conclusion, ALDH2 and alcohol drinking showed interaction for risk factors of stomach cancer, indicating that acetaldehyde plays a role in stomach carcinogenesis.
authors: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan. kmatsuo@aichi-cc.jp
authors: Keitaro
authors: K
authors: Matsuo
authors: Isao
authors: I
authors: Oze
authors: Satoyo
authors: S
authors: Hosono
authors: Hidemi
authors: H
authors: Ito
authors: Miki
authors: M
authors: Watanabe
authors: Kuka
authors: K
authors: Ishioka
authors: Seiji
authors: S
authors: Ito
authors: Masahiro
authors: M
authors: Tajika
authors: Yasushi
authors: Y
authors: Yatabe
authors: Yasumasa
authors: Y
authors: Niwa
authors: Kenji
authors: K
authors: Yamao
authors: Shigeo
authors: S
authors: Nakamura
authors: Kazuo
authors: K
authors: Tajima
authors: Hideo
authors: H
authors: Tanaka
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism; D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000235:genetics; D000444:Aldehyde Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000483:Alleles; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D056726:Genetic Association Studies; D005978:Glutathione / Q000235:genetics / Q000378:metabolism; D016481:Helicobacter Infections / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D016015:Logistic Models; D008239:Lysine / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000201:enzymology / Q000235:genetics*
chemical_list: C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D005978:Glutathione; D000079:Acetaldehyde; D008239:Lysine