title: A point-of-care paper-based fingerstick transaminase test: toward low-cost "lab-on-a-chip" technology for the developing world.
abstract: There is currently great need for high-quality, low-cost, point-of-care diagnostics that can benefit patients in resource-limited settings and correspondingly growing interest in the diagnostic utility of microfluidic platforms that are based on paper. We describe the development, early clinical testing, and potential clinical impact of a novel paper-based, multiplexed microfluidic assay designed for rapid, semiquantitative measurement of aspartate aminotransferase and alanine aminotransferase in a fingerstick specimen. This device ultimately holds promise for providing universal access to affordable point-of-care screening for drug-induced liver injury in resource-limited settings and opens the door to development of similar point-of-care clinical assays for other important analytes.
authors: Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA. npollock@childrens.harvard.edu
authors: Nira R
authors: NR
authors: Pollock
authors: Donn
authors: D
authors: Colby
authors: Jason P
authors: JP
authors: Rolland
mesh_terms: D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D001774:Blood Chemical Analysis / Q000379:methods*; D003906:Developing Countries; D006505:Hepatitis / Q000175:diagnosis*; D006801:Humans; D019095:Point-of-Care Systems; D013048:Specimen Handling / Q000379:methods*
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase