title: Tip-enhanced Raman imaging: an emergent tool for probing biology at the nanoscale.
abstract: Typically limited by the diffraction of light, most optical spectroscopy methods cannot provide the spatial resolution necessary to characterize specimens at the nanoscale. An emerging exception to this rule is tip-enhanced Raman spectroscopy (TERS), which overcomes the diffraction limit through electromagnetic field localization at the end of a sharp metallic tip. As demonstrated by the Zenobi group in this issue of ACS Nano, TER imaging is an analytical technique capable of providing high-resolution chemical maps of biological samples. In this Perspective, we highlight recent advances and future applications of TER imaging as a technique for interrogating biology at the nanoscale.
authors: Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA.
authors: Eric A
authors: EA
authors: Pozzi
authors: Matthew D
authors: MD
authors: Sonntag
authors: Nan
authors: N
authors: Jiang
authors: Jordan M
authors: JM
authors: Klingsporn
authors: Mark C
authors: MC
authors: Hersam
authors: Richard P
authors: RP
authors: Van Duyne
mesh_terms: D001695:Biology / Q000379:methods*; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*; D013059:Spectrum Analysis, Raman / Q000379:methods*