title: Preparation of hybrid soda-lime/quartz glass chips with wettability-patterned channels for manipulation of flow profiles in droplet-based analytical systems.
abstract: Profile switching of two-phase flows is often required in microfluidic systems. Manipulation of flow profiles can be realized by control of local surface energy of micro channel through wettability-patterning of channel surface. This article presents a facile approach for wettability-patterning of the micro channels of glass chips. Commercially available octadecyltrichlorosilane (OTS) was used to hydrophobilize the channels via the formation of OTS self-assembly monolayer (SAM), and a UV-source that mainly emits deep UV-light of 254 and 185 nm was employed to degrade the in-channel formed OTS-SAM. The architecture of soda-lime glass/quartz glass hybrid chip was designed to facilitate the deep UV-light effective degrading the OTS-SAM. The established approach, together with the side-by-side laminar-flow patterning technique, was applied to prepare various finely patterned channel networks for different tasks of flow profile switching. The micro device capable of conducting the profile switch from W/O droplets to two separated continuous phases was demonstrated to perform on-chip quick liquid-liquid extraction for the determination of partition coefficients of pharmaceuticals.
authors: Institute of Micro Analytical Systems, Department of Chemistry, Zhejiang University, Zijin'gang Campus, Hangzhou 310058, China.
authors: Zeqing
authors: Z
authors: Bai
authors: Qiaohong
authors: Q
authors: He
authors: Shanshi
authors: S
authors: Huang
authors: Xianqiao
authors: X
authors: Hu
authors: Hengwu
authors: H
authors: Chen
mesh_terms: D020003:1-Octanol / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry*; D004396:Coloring Agents / Q000737:chemistry; D005898:Glass / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011791:Quartz; D012972:Sodium Hydroxide / Q000737:chemistry*; D012996:Solutions; D013499:Surface Properties; D017155:Wettability
chemical_list: D017610:Calcium Compounds; D004396:Coloring Agents; D010087:Oxides; D004364:Pharmaceutical Preparations; D012996:Solutions; D011791:Quartz; C004569:soda lime; D012972:Sodium Hydroxide; D020003:1-Octanol