title: Changes in conjunctival cytology and tear function tests with radioiodine treatment for hyperthyroidism.
abstract: OBJECTIVE
  Radioiodine (RAI) is used in the treatment of hyperthyroidism and differentiated thyroid cancer. Radioiodine therapy is associated with dry eyes and some side effects are seen especially due to beta rays. In this study, the functional and cytological status of lacrimal glands after RAI therapy was evaluated.
  
  
  METHODS
  Twenty-five patients with a mean age of 55.16 years with planned low-dose RAI therapy were evaluated. Just before and 6 months after the treatment, the lacrimal glands were evaluated with tear break-up time (BUT), Schirmer's test, impression cytology and "Ocular Surface Disease Index (OSDI)" questionnaire.
  
  
  RESULTS
  The mean value of Schirmer's test was 16.20 ± 3.61 pre-treatment and 11.28 ± 4.39 post-treatment for the right eye, and 15.76 ± 3.27 and 10.60 ± 4.42 for the left eye, respectively. The mean value of Schirmer's test decreased significantly post-treatment in both eyes (p = 0.0001). The BUT score also decreased significantly post-treatment (p = 0.001). The mean value of OSDI score was 27.5 ± 8.02 pre-treatment and 46.36 ± 10.27 post-treatment. The mean value of OSDI score increased post-treatment (p = 0.0001). The impression scores also increased post-treatment in both eyes (p = 0.0001).
  
  
  CONCLUSIONS
  Even low-dose (≤30 mci) RAI treatment affects lacrimal gland functions. Low-dose RAI causes a decrease in the value of Schirmer's test and the BUT test, and an increase in the value of OSDI score and impression scores.
authors: Department of Nuclear Medicine, Ministry of Health, Ankara Training and Research Hospital, Ulucanlar Street, 06560, Ankara, Turkey, drgokko@gmail.com.
authors: Gökhan
authors: G
authors: Koca
authors: Ugur
authors: U
authors: Acar
authors: Hasan Ikbal
authors: HI
authors: Atilgan
authors: Damla
authors: D
authors: Ergintürk Acar
authors: Ugur Emrah
authors: UE
authors: Altiparmak
authors: Koray
authors: K
authors: Demirel
authors: Zuleyha
authors: Z
authors: Yalniz-Akkaya
authors: Huseyin
authors: H
authors: Ustun
authors: Meliha
authors: M
authors: Korkmaz
authors: Firdevs
authors: F
authors: Ornek
mesh_terms: D000328:Adult; D000368:Aged; D003228:Conjunctiva / Q000166:cytology* / Q000528:radiation effects*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000532:radiotherapy*; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use; D007765:Lacrimal Apparatus / Q000166:cytology / Q000502:physiology / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D013666:Tears / Q000502:physiology* / Q000528:radiation effects*
chemical_list: D007457:Iodine Radioisotopes