title: A case of treating cathinone dependence and comorbid depression using bupropion.
abstract: Cathinone is a potent CNS stimulant found in khat leaves. Cathinone and synthetic cathinone-derivatives have become popular recreational drugs in recent years, commonly marketed as "legal highs." In addition to acute physical and psychiatric adverse effects, dependence on these substances is a concern. The following case reports describes a young man with cathinone dependence and depression that was treated using bupropion. Bupropion is a cathinone-derivative with a dual dopamine-norepinephrine reuptake inhibiting mechanism, which is approved for the treatment of depression and smoking cessation. Clinical awareness to the addictive potential of cathinone and cathinone-derivatives is important. Research regarding the potential effectiveness of bupropion in these cases is needed.
authors: Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel. shauli.levran@gmail.com
authors: Shaul
authors: S
authors: Lev-Ran
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000627:therapeutic use*; D000470:Alkaloids; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000188:drug therapy; D016642:Bupropion / Q000627:therapeutic use*; D029754:Catha; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D015198:Designer Drugs; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy*; D059020:Suicidal Ideation; D055815:Young Adult
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000470:Alkaloids; D018687:Antidepressive Agents, Second-Generation; D000697:Central Nervous System Stimulants; D015198:Designer Drugs; D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D008774:Methylphenidate; C023665:cathinone