title: Li-gazing at the crest: modulation of the neural crest by the ubiquitin pathway.
abstract: Neural crest cells are a transient population of stem cells that give rise to a diverse range of cell types during embryonic development. Through gain-of-function and loss-of-function studies in several model organisms many key signalling pathways and cell-type specific transcription factors essential for neural crest cell development have been identified. However, the role of post-translational regulation remains largely unexplored. Here we review this cell type with a foray into the known and potential roles of the ubiquitination pathway in key signalling events during neural crest cell development.
authors: Centre for Cancer Biology, SA Pathology, Adelaide 5000, Australia.
authors: Sophie
authors: S
authors: Wiszniak
authors: Rachael
authors: R
authors: Lumb
authors: Samuela
authors: S
authors: Kabbara
authors: Michaela
authors: M
authors: Scherer
authors: Quenten
authors: Q
authors: Schwarz
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D009432:Neural Crest / Q000166:cytology / Q000196:embryology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism*; D054875:Ubiquitination / Q000502:physiology*
chemical_list: D014157:Transcription Factors; D025801:Ubiquitin