title: Comparison between unsintered hydroxyapatite/poly-L-lactic acid mesh and titanium mesh in bone regeneration of rabbit mandible.
abstract: OBJECTIVE
  The purpose of this study was to compare the bone regenerative capability of using unsintered hydroxyapatite/poly-L-lactic acid (uHA/PLLA) mesh and titanium mesh.
  
  
  METHODS
  Adult male white rabbits (n = 24) were divided into 2 groups. After incising along the mandible, 3 × 5 mm bone defects were made in both sides and covered by an uHA/PLLA mesh (n = 12) or a titanium mesh (n = 12) on the right side but no mesh on the left side (n = 12). The rabbits were sacrificed at 1, 2, and 4 weeks postoperatively, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immunohistochemical analysis, the specimens were treated with BMP-2.
  
  
  RESULTS
  The titanium group and uHA/PLLA group were significantly larger than the control group regarding the bone area ratio postoperatively at 2 and 4 weeks. However, there were no significant differences between the uHA/PLLA group and titanium group regarding the BMP-2.
  
  
  CONCLUSIONS
  This study suggested that the uHA/PLLA mesh could increase new bone formation more than the absence of a mesh in bone defects. However, there was no significant difference between uHA/PLLA mesh and the titanium mesh in bone augmentation.
authors: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.
authors: Akinori
authors: A
authors: Moroi
authors: Koichiro
authors: K
authors: Ueki
authors: Katsuhiko
authors: K
authors: Okabe
authors: Kohei
authors: K
authors: Marukawa
authors: Megumi
authors: M
authors: Sotobori
authors: Aya
authors: A
authors: Mukozawa
authors: Mao
authors: M
authors: Miyazakia
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism; D001861:Bone Regeneration; D003799:Dental Stress Analysis; D017886:Durapatite; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008334:Mandible / Q000601:surgery; D011091:Polyesters; D011817:Rabbits; D013526:Surgical Mesh; D014025:Titanium
chemical_list: D055396:Bone Morphogenetic Protein 2; D011091:Polyesters; C499699:hydroxyapatite-polylactide; D017886:Durapatite; D014025:Titanium