title: Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital.
abstract: Noni (Morinda citrifolia) juice is a popular herbal dietary supplement globally used for preventive or therapeutic purposes in a variety of ailments, claiming to exhibit hepatoprotective properties as well. Herein we present the case of a 38-year-old woman who developed acute liver injury associated with noni juice consumption on a long-term (9 months) anticonvulsant therapy. Clinical presentation and liver biopsy were consistent with severe, predominantly hepatocellular type of injury. Both agents were stopped and corticosteroids were initiated. Five months later the patient had fully recovered. Although in the literature the hepatotoxicity of noni juice remains speculative, sporadic but emerging cases of noni juice-associated liver injury address the need to clarify and investigate potential harmful effects associated with this supplement.
authors: Department of Medicine, University Hospital Merkur, Zagreb, Croatia ; Department of School of Medicine, University of Zagreb, Zagreb, Croatia.
authors: Anna
authors: A
authors: Mrzljak
authors: Iva
authors: I
authors: Kosuta
authors: Anita
authors: A
authors: Skrtic
authors: Tajana Filipec
authors: TF
authors: Kanizaj
authors: Radovan
authors: R
authors: Vrhovac
keywords: Drug-induced liver injury; Herb-induced liver injury; Noni juice; Phenobarbital