title: [Dilution volume of intravenous drugs in patients under fluid restriction therapy].
abstract: BACKGROUND
  A fluid and electrolyte balance is essential for human health. There are some situations in which fluid imbalance occurs, causing fluid overload and consequent associated problems. Patients with these problems, may benefit from the administration of parenteral drugs in the smallest possible volume. Patients in critical condition typically require a large number of drugs intravenously, and high doses of these diluted in large quantities of serum. Therefore, it seems useful to seek an optimization strategy of parenteral drug admi - nistration.
  
  
  OBJECTIVE
  To review and collect data on minimum dilution volumes. Besides administration s routes, reconstitution, compatible diluents, infusion times.
  
  
  METHODS
  The study included those drug substances frequently used in critically ill patients. A search through multiple sources of information has been made: technical data for Propietary medicinal products, Handbook on Injectable Drugs, Trissel L., American Society Healh-System Pharmacists, 15thEd., 2009, Thomson Micromedex® Healthcare Series, or by phone calls to the manufacturers of the product.
  
  
  RESULTS
  RESULTS are shown in a table. 65 drugs were revised.
  
  
  CONCLUSIONS
  It is considered useful the collection of these data to optimize parenteral administration in critically ill patients, or in those who require restrictive fluid therapy, because information has been collected from different sources, not always found it in the technical data of the drugs.
authors: B
authors: B
authors: Proy Vega
authors: E
authors: E
authors: Domingo Chiva
authors: C
authors: C
authors: García Gómez
authors: M
authors: M
authors: Hernández Sansalvador
authors: E M
authors: EM
authors: García Martínez
mesh_terms: D016638:Critical Illness; D004339:Drug Compounding; D004347:Drug Interactions; D006801:Humans; D007201:Indicator Dilution Techniques; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D014883:Water-Electrolyte Imbalance / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations