title: Monitoring chronic physical stress using biomarkers, performance protocols and mathematical functions to identify physiological adaptations in rats.
abstract: This study was undertaken to characterize the effects of monotonous training at lactate minimum (LM) intensity on aerobic and anaerobic performances; glycogen concentrations in the soleus muscle, the gastrocnemius muscle and the liver; and creatine kinase (CK), free fatty acids and glucose concentrations in rats. The rats were separated into trained (n = 10), baseline (n = 10) and sedentary (n = 10) groups. The trained group was submitted to the following: 60 min/day, 6 day/week and intensity equivalent to LM during the 12-week training period. The training volume was reduced after four weeks according to a sigmoid function. The total CK (U/L) increased in the trained group after 12 weeks (742.0 ± 158.5) in comparison with the baseline (319.6 ± 40.2) and the sedentary (261.6 ± 42.2) groups. Free fatty acids and glycogen stores (liver, soleus muscle and gastrocnemius muscle) increased after 12 weeks of monotonous training but aerobic and anaerobic performances were unchanged in relation to the sedentary group. The monotonous training at LM increased the level of energy substrates, unchanged aerobic performance, reduced anaerobic capacity and increased the serum CK concentration; however, the rats did not achieve the predicted training volume.
authors: Laboratory of Sports Applied Physiology, Campinas State University (UNICAMP), 13484-350, Limeira, Sao Paulo, Brazil.
authors: Gustavo Gomes
authors: GG
authors: de Araujo
authors: Marcelo
authors: M
authors: Papoti
authors: Fúlvia de Barros
authors: Fde B
authors: Manchado-Gobatto
authors: Maria Alice Rostom
authors: MA
authors: de Mello
authors: Claudio Alexandre
authors: CA
authors: Gobatto
mesh_terms: D000222:Adaptation, Physiological; D000827:Animal Welfare; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D005082:Physical Exertion; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological
chemical_list: D015415:Biomarkers; D005230:Fatty Acids, Nonesterified; D006003:Glycogen; D003402:Creatine Kinase; D005947:Glucose