title: [Role of vitamin D in HIV infection].
abstract: Besides its role in bone metabolism, vitamin D shows properties on autoimmune, oncological, cardiovascular, metabolic, or infectious diseases. In this article, we talk about interpellant relationships between vitamin D and HIV. This hormone plays an important role in HIV infection, as much at a skeletal level than in the course of the disease itself. First, we notice that a low vitamin D status is currently associated with HIV infection. Moreover, it is now known that low rate of 1,25-dihydroxyvitamin D in HIV patients is associated with advanced clinical HIV infection and increased mortality. Thus, vitamin D deficiency has to be considered as an important factor in HIV progression. Indeed, vitamin D increases macrophage activity, in some way through autophagy, and this process can inhibit HIV-1 infection. Then we consider the implications of antiretroviral therapies on vitamin D metabolism. We finally evaluate the benefits of a vitamin D supplementation in HIV + patients.
authors: Service de Médecine Interne-Maladies infectieuses, CHU de Liège, Belgique.
authors: B F
authors: BF
authors: Pirotte
authors: M
authors: M
authors: Rassenfosse
authors: R
authors: R
authors: Collin
authors: A
authors: A
authors: Devoeght
authors: M
authors: M
authors: Moutschen
authors: E
authors: E
authors: Cavalier
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage; D044966:Anti-Retroviral Agents / Q000008:administration & dosage; D019587:Dietary Supplements; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D014807:Vitamin D / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology
chemical_list: D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents; D014807:Vitamin D