title: Vacuolar-type proton pump ATPases: acidification and pathological relationships.
abstract: Vacuolar H(+)(-)translocating ATPase (V-ATPase) is a universal proton pump, and its activity is required for a variety of cell biological processes, such as membrane trafficking, receptor-mediated endocytosis, lysosomal degradation of macromolecules, osteoclastic bone resorption, and the maintenance of acid-base homeostasis by renal intercalated cells. V-ATPase is targeted to various membranes and has different compositions depending on its cellular location. Here, we focus on recent knowledge concerning the targeting mechanism of V-ATPase, a process associated with a wide spectrum of diseases. We also discuss the functions of this enzyme in macrophages and cancer cells-2 characteristic cell types with clinical importance.
authors: Faculty of Pharmaceutical Sciences, Doshisha Woman's College, Kohdo, Kyotanabe, Kyoto, Japan. kwada@dwc.doshisha.ac.jp
authors: Ge-Hong
authors: GH
authors: Sun-Wada
authors: Yoh
authors: Y
authors: Wada
mesh_terms: D000136:Acid-Base Equilibrium; D000818:Animals; D002384:Catalysis; D004705:Endocytosis; D005656:Fungal Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000378:metabolism; D051379:Mice; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism; D009995:Osmosis; D010010:Osteoclasts / Q000378:metabolism; D017434:Protein Structure, Tertiary; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D049452:Green Fluorescent Proteins; D025262:Vacuolar Proton-Translocating ATPases