title: Oxaliplatin-induced acute thrombocytopenia: a case report and review of the literature.
abstract: We herein report the case of a 77-year-old woman who developed acute thrombocytopenia during the 23rd cycle of modified FOLFOX therapy. She developed a hypersensitivity reaction with nasal bleeding. The chemotherapy infusion was immediately discontinued. The patient's symptoms resolved with discontinuation of chemotherapy and the administration of supportive therapy. A complete blood count showed severe thrombocytopenia, and oxaliplatin-induced thrombocytopenia was diagnosed. The patient was admitted to the hospital, and the thrombocytopenia was corrected with a platelet transfusion followed by prednisolone. She was discharged after one week without requiring additional platelet transfusions. With the widespread use of oxaliplatin, the risk of oxaliplatin-induced acute thrombocytopenia should be considered an acute onset hematological emergency.
authors: Department of Hematology and Oncology, Mie University Graduate School of Medicine, Japan. keis@clin.medic.mie-u.ac.jp
authors: Kei
authors: K
authors: Suzuki
authors: Hiroyasu
authors: H
authors: Oda
authors: Yumiko
authors: Y
authors: Sugawara
authors: Masahiro
authors: M
authors: Masuya
authors: Kazunori
authors: K
authors: Nakase
authors: Masaki
authors: M
authors: Fujioka
authors: Hiroshi
authors: H
authors: Imai
authors: Naoyuki
authors: N
authors: Katayama
mesh_terms: D000208:Acute Disease; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin