title: 6-Gingerol inhibits hair shaft growth in cultured human hair follicles and modulates hair growth in mice.
abstract: Ginger (Zingiber officinale) has been traditionally used to check hair loss and stimulate hair growth in East Asia. Several companies produce shampoo containing an extract of ginger claimed to have anti-hair loss and hair growth promotion properties. However, there is no scientific evidence to back up these claims. This study was undertaken to measure 6-gingerol, the main active component of ginger, on hair shaft elongation in vitro and hair growth in vivo, and to investigate its effect on human dermal papilla cells (DPCs) in vivo and in vitro. 6-Gingerol suppressed hair growth in hair follicles in culture and the proliferation of cultured DPCs. The growth inhibition of DPCs by 6-gingerol in vitro may reflect a decrease in the Bcl-2/Bax ratio. Similar results were obtained in vivo. The results of this study showed that 6-gingerol does not have the ability to promote hair growth, on the contrary, can suppress human hair growth via its inhibitory and pro-apoptotic effects on DPCs in vitro, and can cause prolongation of telogen phase in vivo. Thus, 6-gingerol rather than being a hair growth stimulating drug, it is a potential hair growth suppressive drug; i.e. for hair removal.
authors: Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors: Yong
authors: Y
authors: Miao
authors: Yabin
authors: Y
authors: Sun
authors: Wenjun
authors: W
authors: Wang
authors: Benjun
authors: B
authors: Du
authors: Shun-e
authors: SE
authors: Xiao
authors: Yijue
authors: Y
authors: Hu
authors: Zhiqi
authors: Z
authors: Hu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002396:Catechols / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D020405:Dermis / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005233:Fatty Alcohols / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D020939:Zingiber officinale / Q000737:chemistry*; D018859:Hair Follicle / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D006204:Hair Removal / Q000379:methods; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000737:chemistry*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism
chemical_list: D002396:Catechols; D005233:Fatty Alcohols; D010936:Plant Extracts; D019253:Proto-Oncogene Proteins c-bcl-2; C007845:gingerol