title: Association between the variable number of tandem repeat polymorphism in the third exon of the dopamine D4 receptor gene and sensitivity to analgesics and pain in patients undergoing painful cosmetic surgery.
abstract: To elucidate the mechanisms of individual differences in pain and analgesic sensitivity, we analyzed the variable number of tandem repeat polymorphism in the third exon of the dopamine D4 receptor gene. Alleles that were less than four repeats long and four or more repeats long were considered Short and Long, respectively. We found that the Short/Short genotype group was significantly more sensitive to pain and less sensitive to analgesics than the Short/Long+Long/Long genotype group. Our data suggest that this polymorphism may predict individual differences in pain and analgesic sensitivity and help achieve adequate pain control in the future.
authors: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. aoki-ys@igakuken.or.jp
authors: Yoshinori
authors: Y
authors: Aoki
authors: Daisuke
authors: D
authors: Nishizawa
authors: Shinya
authors: S
authors: Kasai
authors: Ken-Ichi
authors: K
authors: Fukuda
authors: Tatsuya
authors: T
authors: Ichinohe
authors: Shuichiro
authors: S
authors: Yamashita
authors: Kazutaka
authors: K
authors: Ikeda
mesh_terms: D000293:Adolescent; D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D003357:Cosmetic Techniques; D005091:Exons; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D059229:Osteotomy, Sagittal Split Ramus; D010149:Postoperative Pain / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D050638:Receptors, Dopamine D4 / Q000235:genetics*; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D050638:Receptors, Dopamine D4