title: Determinants of nucleosome positioning.
abstract: Nucleosome positioning is critical for gene expression and most DNA-related processes. Here we review the dominant patterns of nucleosome positioning that have been observed and summarize the current understanding of their underlying determinants. The genome-wide pattern of nucleosome positioning is determined by the combination of DNA sequence, ATP-dependent nucleosome remodeling enzymes and transcription factors that include activators, components of the preinitiation complex and elongating RNA polymerase II. These determinants influence each other such that the resulting nucleosome positioning patterns are likely to differ among genes and among cells in a population, with consequent effects on gene expression.
authors: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA. kevin@hms.harvard.edu
authors: Kevin
authors: K
authors: Struhl
authors: Eran
authors: E
authors: Segal
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001483:Base Sequence; D042002:Chromatin Assembly and Disassembly; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D009707:Nucleosomes / Q000235:genetics* / Q000378:metabolism*; D011067:Poly dA-dT; D012319:RNA Polymerase II / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D009707:Nucleosomes; D014157:Transcription Factors; D011067:Poly dA-dT; D000255:Adenosine Triphosphate; D012319:RNA Polymerase II