title: Asthma and influenza virus infection:focusing on cell death and stress pathways in influenza virus replication.
abstract: Asthma is one of the fastest growing syndromes in many countries and is adding a huge cost to the health care system. Increasing reports have linked airway infectious diseases to asthma. Influenza is one of the most serious airway infectious diseases and in recent years there have been some serious influenza virus pandemics which caused increased fatality in numerous different populations. Diverse host response pathways during virus infection have been identified, including different cell death and survival pathways. These pathways include 1) programmed cell death I (apoptosis), 2) programmed cell death II (autophagy), and 3) endoplasmic reticulum stress with subsequent unfolded protein response (UPR). There has been extensive research on the regulatory roles of these pathways during the influenza virus life cycle. These studies address the benefits of enhancing or inhibiting these pathways on viral replication. Here we review the most recent and significant knowledge in this area for possible benefits to clinicians and basic scientist researchers in different areas of the respiratory and virology sciences.
authors: Department of Physiology, University of Manitoba, Winnipeg, Canada. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada. saeid.ghavami@gmail.com, and kcoombs@cc.umanitoba.ca.
authors: Behzad
authors: B
authors: Yeganeh
authors: Adel
authors: A
authors: Rezaei Moghadam
authors: Ahn Thuy
authors: AT
authors: Tran
authors: Mohammad Niaz
authors: MN
authors: Rahim
authors: Sudu R
authors: SR
authors: Ande
authors: Mohammad
authors: M
authors: Hashemi
authors: Kevin M
authors: KM
authors: Coombs
authors: Saeid
authors: S
authors: Ghavami
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D001249:Asthma / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D001343:Autophagy / Q000235:genetics*; D059865:Endoplasmic Reticulum Stress / Q000235:genetics*; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D007251:Influenza, Human / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D009975:Orthomyxoviridae / Q000502:physiology*; D044764:Ubiquitin-Activating Enzymes / Q000235:genetics / Q000378:metabolism; D056811:Unfolded Protein Response / Q000235:genetics; D014779:Virus Replication
chemical_list: D051017:Apoptosis Regulatory Proteins; D044764:Ubiquitin-Activating Enzymes