title: Serum selenium is low in newly diagnosed Graves' disease: a population-based study.
abstract: BACKGROUND
  Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease.
  
  
  OBJECTIVE
  To compare serum selenium (s-Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population.
  
  
  METHODS
  S-Se was measured in triplicate by a fluorimetric method.
  
  
  METHODS
  Patients with newly diagnosed Graves' disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO-Ab) (TPO-Ab > 1500 U/ml, n = 92) and random controls (n = 830).
  
  
  METHODS
  Differences in s-Se values.
  
  
  RESULTS
  S-Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s-Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s-Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s-Se between euthyroid participants with high TPO-Ab and random controls (linear: P = 0·97; multivariate: P = 0·27).
  
  
  CONCLUSIONS
  Patients with newly diagnosed GD and AIH had significantly lower s-Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD.
authors: Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. I.Bulow@rn.dk
authors: Inge
authors: I
authors: Bülow Pedersen
authors: Nils
authors: N
authors: Knudsen
authors: Allan
authors: A
authors: Carlé
authors: Lutz
authors: L
authors: Schomburg
authors: Josef
authors: J
authors: Köhrle
authors: Torben
authors: T
authors: Jørgensen
authors: Lone Banke
authors: LB
authors: Rasmussen
authors: Lars
authors: L
authors: Ovesen
authors: Peter
authors: P
authors: Laurberg
mesh_terms: D000328:Adult; D003718:Denmark; D005260:Female; D006111:Graves Disease / Q000097:blood* / Q000175:diagnosis; D050031:Hashimoto Disease / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011159:Population Surveillance / Q000379:methods*; D012643:Selenium / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood; D013967:Thyroiditis, Autoimmune
chemical_list: D013963:Thyroid Hormones; D012643:Selenium