title: Chitosan-hydroxyapatite composites.
abstract: Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers such as chitosan and its derivatives, and minerals such as calcium phosphates has grown significantly over the last two decades due to its renewable and biodegradable source, increasing the knowledge and functionality of composites in technological and biomedical applications. The properties of bone in health and disease attract much attention. A great proportion of the population need those medical devices for hard tissue regeneration and/or replacement, the pressure on the health systems in all countries became substantial. The short review focus in biomaterials such as chitosan and calcium phosphates composites with excellent properties such as biocompatibility, biofunctionality, and non-antigenic, showing the feasibility and ideal material to treat musculoskeletal disorders for hard tissue regeneration.
authors: Institute of Biopolymers and Chemical Fibers - IBWCh, Sklodowskiej-Curie 19/27, 90-570 Lodz, Poland. pighinelli@hotmail.com
authors: Luciano
authors: L
authors: Pighinelli
authors: Magdalena
authors: M
authors: Kucharska
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000737:chemistry; D002448:Cell Adhesion; D048271:Chitosan / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D009140:Musculoskeletal Diseases / Q000628:therapy; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D048271:Chitosan; D017886:Durapatite; C020243:calcium phosphate