title: The anti-wrinkle efficacy of Argireline.
abstract: BACKGROUND
  Argireline, a synthetic peptide, which is patterned from the N-terminal end of the protein SNAP-25, can both reduce the degree of existing facial wrinkles and demonstrate effectively against their development. In our past studies, we found out that Argireline had a significant anti-wrinkle effect in Chinese subjects and that it was safe and well tolerated.
  
  
  OBJECTIVE
  To observe the effect of Argireline on histological changes in the skin in the aged mice induced by D-galactose.
  
  
  METHODS
  Argireline was applied to the aged mice twice daily for 6 weeks. The histological changes in skin tissue were evaluated using hematoxylin-eosin (HE) and picrosirius-polarization (PSP) stains. The amount of type I and of type III collagen fibers were also semi-quantitatively compared using software Image-ProPlus.
  
  
  RESULTS
  There was an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased (P < 0.01), while that of type III collagen fibers decreased (P < 0.05).
  
  
  CONCLUSIONS
  This study revealed that Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin.
authors: The second hospital of Xi'an Jiaotong University, Xi'an, PR China. wangmei6972@163.com
authors: Yuan
authors: Y
authors: Wang
authors: Mei
authors: M
authors: Wang
authors: Xiang Sheng
authors: XS
authors: Xiao
authors: Jia
authors: J
authors: Huo
authors: Wei Ding
authors: WD
authors: Zhang
mesh_terms: D000818:Animals; D024042:Collagen Type I / Q000187:drug effects / Q000378:metabolism; D024061:Collagen Type III / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D012867:Skin / Q000033:anatomy & histology; D015595:Skin Aging / Q000187:drug effects*; D013194:Staining and Labeling
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III; D009842:Oligopeptides; C582852:acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide