title: Analysis of new N-category on prognosis of oesophageal cancer with positive lymph nodes in a Chinese population.
abstract: BACKGROUND
  The 7(th) edition of the new TNM classification system for oesophageal cancer (EC) has been published. N-category is now divided into N0, N1, N2 and N3. In this study, we aimed to validate the prognostic ability of the new N classification system in EC with positive lymph nodes in a Chinese population, and evaluate whether the new N classification system can help the decision-making for postoperative adjuvant therapy.
  
  
  METHODS
  From 2002 to 2008, thoracic EC who underwent oesophagectomy were retrospectively analysed. Patients pathological stage 6(th) edition of the American Joint Committee on Cancer / Union International Against Cancer (AJCC/UICC) TNM classification were switched to pathological stage 7(th) edition for this analysis. Patients with pathological stage T1-4N1-3M0 EC were selected. Kaplan-Meier method and Cox regression analysis were employed to compare overall survival (OS).
  
  
  RESULTS
  A total of 545 patients met the inclusion criteria: 346 (63.5%) received oesophagectomy alone, 199 (36.5%) received oesophagectomy and adjuvant radiotherapy, and 36.1% (197/545) received oesophagectomy and adjuvant chemotherapy. Univariate analysis and multivariate analysis revealed significant difference in OS among patients at different postoperative pN-category (p<0.001). This was also present in patients receiving postoperative radiotherapy (p<0.001) and those undergoing postoperative chemotherapy (p<0.001). There was no marked difference in OS between patients receiving postoperative adjuvant therapy and surgery alone at the same postoperative pN-category, except that postoperative radiotherapy marginally improved OS in patients with pN2 and pN3 disease.
  
  
  CONCLUSIONS
  Our results validated the prognostic ability of new N classification system. The N-category is an independent prognostic factor in patients with resectable thoracic EC who were positive for lymph nodes in a Chinese population. Further studies are required to clarify the role of new N classification system in the decision-making for postoperative adjuvant therapy.
authors: Department of Radiation Oncology; Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
authors: Yaping
authors: Y
authors: Xu
authors: Youhua
authors: Y
authors: Jiang
authors: Xinmin
authors: X
authors: Yu
authors: Qixun
authors: Q
authors: Chen
authors: Xinming
authors: X
authors: Zhou
authors: Weimin
authors: W
authors: Mao
keywords: chemotherapy; oesophageal cancer; oesophagectomy; prognostic factor; radiotherapy