title: Nano-extrusion: a one-step process for manufacturing of solid nanoparticle formulations directly from the liquid phase.
abstract: This paper presents a novel one-step process for converting a liquid stabilized nano-suspension into a solid formulation via hot-melt extrusion combined with an internal devolatilization process (nano-extrusion, NANEX). A polymer (Soluplus®) was fed into the extruder and molten, after which a stable nano-suspension was added via side-feeding devices. The solvent (water) was removed by devolatilization and the polymer solidified at the outlet. The solid material can be tableted or filled in a capsule directly. The results showed that the obtained extrudates comprised nanocrystals in the de-aggregated form, confirming that a solid nano-formulation was prepared. This method is capable of overcoming many of the problems associated with other processes involving solid nano-dosage forms and poses a straightforward approach towards manufacturing such products.
authors: Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria.
authors: Johannes
authors: J
authors: Khinast
authors: Ramona
authors: R
authors: Baumgartner
authors: Eva
authors: E
authors: Roblegg
mesh_terms: D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D006358:Hot Temperature; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D036103:Nanotechnology; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D013678:Technology, Pharmaceutical / Q000379:methods*; D014025:Titanium / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D004304:Dosage Forms; D011145:Polyvinyls; D012997:Solvents; C572167:polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; D014867:Water; C009495:titanium dioxide; D011092:Polyethylene Glycols; D014025:Titanium