title: Systematic analysis of genomic organization and structure of long non-coding RNAs in the human genome.
abstract: The genomic architecture of several functional elements in animals and plants, such as microRNAs and tRNA, has been better characterized. As yet, there is very little known about genomic organization and structure of lncRNA in animals and plants. Here, we conducted a genome-wide systematic computational analysis of genomic architecture of lncRNAs, and further provided a more comprehensive comparative view of genomic organization between lncRNAs and several other functional elements in the human genome. Our study not only provides comprehensive knowledge for further studies into the correlations between the genomic architecture of lncRNAs and their important functional roles in diverse cellular processes and in disease, but also will be valuable for understanding the origin and evolution of lncRNAs.
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
authors: Jie
authors: J
authors: Sun
authors: Meng
authors: M
authors: Zhou
authors: Zhi-Tao
authors: ZT
authors: Mao
authors: Da-Peng
authors: DP
authors: Hao
authors: Zhen-Zhen
authors: ZZ
authors: Wang
authors: Chuan-Xing
authors: CX
authors: Li
mesh_terms: D000465:Algorithms; D002873:Chromosome Fragility / Q000235:genetics; D002874:Chromosome Mapping; D019295:Computational Biology / Q000379:methods*; D019143:Evolution, Molecular; D015894:Genome, Human / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics
chemical_list: D062085:RNA, Long Noncoding