title: Exhausting T cells in CLL.
abstract: In this issue of Blood, Riches and colleagues provide an in-depth characterization of T cells and particularly CD8+ T cells from patients with chronic lymphocytic leukemia (CLL). They demonstrate that CD8+ T cells exhibit defects in proliferation, cytotoxicity, and increased expression of inhibitory receptors and thus exhibit features of T-cell exhaustion.
authors: NCT/DKFZ, University of Heidelberg.
authors: Thorsten
authors: T
authors: Zenz
mesh_terms: D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism* / Q000502:physiology*
chemical_list: D016207:Cytokines