title: Assembly of substituted 3-aminoindazoles from 2-bromobenzonitrile via a CuBr-catalyzed coupling/condensation cascade process.
abstract: CuBr-catalyzed coupling reaction of 2-halobenzonitriles with hydrazine carboxylic esters and CuBr/4-hydroxy-l-proline-catalyzed coupling reaction of 2-bromobenzonitriles with N'-arylbenzohydrazides proceed smoothly at 60-90 °C to provide substituted 3-aminoindazoles through a cascade coupling/condensation (or coupling/deacylation/condensation) process. A wide range of 3-aminoindazoles with substituents at both the 1-position and the phenyl ring part can be prepared from the corresponding coupling partners.
authors: Department of Chemistry, Fudan University, Shanghai 200433, China.
authors: Lanting
authors: L
authors: Xu
authors: Yinsheng
authors: Y
authors: Peng
authors: Qiangbiao
authors: Q
authors: Pan
authors: Yongwen
authors: Y
authors: Jiang
authors: Dawei
authors: D
authors: Ma
mesh_terms: D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*
chemical_list: C583554:2-bromobenzonitrile; D001965:Bromides; D007191:Indazoles; D009570:Nitriles; C408079:cupric bromide; D003300:Copper