title: Microtubule-targeting Anticancer Agents from Marine Natural Source.
abstract: The effective novel therapeutics is urgently needed due to the increasing incidence of malignant cancers and drug multi-resistance. It is particularly imperative to find efficacious and specific anticancer agents. Microtubule-targeting drugs are among the most commonly prescribed agents in the combat against cancer. Natural products and their derivatives have historically been invaluable as a source of pharmaceutical leads and therapeutic agents. In particular, marine natural products (MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides new pathway and ideas to find original anticancer agents, and enjoys a renaissance in the past few years. In this review, nine classes of typical MNPs are summarized, including novel compounds with diverse structures. Most bioactive marine compounds from different organism include invertebrate animals, algae, fungi and bacteria are concluded.
authors: School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. wbzeng@hotmail.com.
authors: Zhiguo
authors: Z
authors: Liu
authors: Pengfei
authors: P
authors: Xu
authors: Lun
authors: L
authors: Yu
authors: Wenbin
authors: W
authors: Zeng