title: Association of aryl hydrocarbon receptor gene polymorphism with the neurobehavioral function and autonomic nervous system function changes induced by benzo[a]pyrene exposure in coke oven workers.
abstract: OBJECTIVE
  To analyze the association of aryl hydrocarbon receptor (AhR) gene polymorphism and the neurotoxicity induced by benzo[a]pyrene (B[a]P) in coke oven workers.
  
  
  METHODS
  Subjects, 214 coke oven workers and 81 controls, were detected for neurobehavioral function and autonomic nervous system (ANS) function. Airborne B[a]P concentration, urinary 1-hydroxypyrene level, and AhR gene polymorphisms were determined and analyzed for their association with B[a]P neurotoxicity.
  
  
  RESULTS
  Neurobehavioral function and ANS function were significantly decreased and dependent on B[a]P dose. The AhR GG, GA, and AA genotypes in G1661A fitted the Hardy-Weinberg equation, whereas C1549T and G1708A gene mutants were not detected. Indices indicating neurotoxicity showed no significant difference among individuals with AA, GG, or GA genotype except for the confusion-bewilderment (P > 0.05).
  
  
  CONCLUSIONS
  The AhR gene polymorphism is not thought to correlate with B[a]P neurotoxicity among coke oven workers.
authors: Department of Occupational and Environmental Health, Shanxi Medical University, Taiyuan, PR China.
authors: Hongmei
authors: H
authors: Zhang
authors: Jisheng
authors: J
authors: Nie
authors: Xin
authors: X
authors: Li
authors: Qiao
authors: Q
authors: Niu
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics / Q000652:urine; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D001564:Benzo(a)pyrene / Q000009:adverse effects* / Q000032:analysis; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D002681:China; D003077:Coke; D019652:Extraction and Processing Industry; D005819:Genetic Markers; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics* / Q000652:urine; D009483:Neuropsychological Tests; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000652:urine; D009784:Occupational Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics* / Q000652:urine; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D020641:Polymorphism, Single Nucleotide; D011721:Pyrenes / Q000652:urine; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics*; D011795:Surveys and Questionnaires
chemical_list: D000395:Air Pollutants, Occupational; D051792:Basic Helix-Loop-Helix Proteins; D001564:Benzo(a)pyrene; D015415:Biomarkers; D003077:Coke; D005819:Genetic Markers; D011721:Pyrenes; D018336:Receptors, Aryl Hydrocarbon; C111235:AHR protein, human; C033146:1-hydroxypyrene