title: Synthesis and biological evaluation of nitrogen mustard derivatives of purine bases.
abstract: This paper deals with the synthesis of nitrogen mustard analogs, derivatives of purine bases. Alkylation in position N-9 and diethanolamine fixation on position 6 were managed by microwave irradiations. Chlorination of these dihydroxylated intermediates led to a cyclization, giving tricyclic purine base analogs bearing a chloroethyl chain. Finally, MTT assays on obtained compounds do not show cytotoxicity on four different cancer cell lines.
authors: Laboratoire de Chimie des Substances Naturelles, Limoges, France.
authors: Benjamin
authors: B
authors: Boëns
authors: Mounir
authors: M
authors: Azouz
authors: Tan-Sothea
authors: TS
authors: Ouk
authors: Rachida
authors: R
authors: Zerrouki
mesh_terms: D000478:Alkylation; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D054879:Halogenation; D006801:Humans; D008466:Mechlorethamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D011687:Purines; D008466:Mechlorethamine