title: Relationship between the electron density of the heme Fe atom and the vibrational frequencies of the Fe-bound carbon monoxide in myoglobin.
abstract: We analyzed the vibrational frequencies of the Fe-bound carbon monoxide (CO) of myoglobin reconstituted with a series of chemically modified heme cofactors possessing a heme Fe atom with a variety of electron densities. The study revealed that the stretching frequency of Fe-bound CO (ν(CO)) increases with decreasing electron density of the heme Fe atom (ρ(Fe)). This finding demonstrated that the ν(CO) value can be used as a sensitive measure of the ρ(Fe) value and that the π back-donation of the heme Fe atom to CO is affected by the heme π-system perturbation induced through peripheral side chain modifications.
authors: Department of Chemistry, University of Tsukuba, Tsukuba 305-8571, Japan.
authors: Ryu
authors: R
authors: Nishimura
authors: Tomokazu
authors: T
authors: Shibata
authors: Hulin
authors: H
authors: Tai
authors: Izumi
authors: I
authors: Ishigami
authors: Takashi
authors: T
authors: Ogura
authors: Satoshi
authors: S
authors: Nagao
authors: Takashi
authors: T
authors: Matsuo
authors: Shun
authors: S
authors: Hirota
authors: Kiyohiro
authors: K
authors: Imai
authors: Saburo
authors: S
authors: Neya
authors: Akihiro
authors: A
authors: Suzuki
authors: Yasuhiko
authors: Y
authors: Yamamoto
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism*; D004583:Electrons; D006418:Heme / Q000737:chemistry* / Q000378:metabolism*; D007501:Iron / Q000737:chemistry*; D007700:Kinetics; D009211:Myoglobin / Q000378:metabolism*; D014732:Vibration
chemical_list: D009211:Myoglobin; D006418:Heme; D002248:Carbon Monoxide; D007501:Iron