title: Rearranged abietane diterpenoids from the roots of Clerodendrum trichotomum and their cytotoxicities against human tumor cells.
abstract: The roots of the medicinal ornamental plant Clerodendrum trichotomum yielded a series of rearranged abietane diterpenoids, including three 17(15→16)-abeo-abietane (1-3) and three 17(15→16),18(4→3)-diabeo-abietane (4-6) derivatives. Their structures were elucidated by means of spectroscopic methods. The absolute configuration of (10R,16R)-12,16-epoxy-11,14,17-trihydroxy-6-methoxy-17(15→16)-abieta-5,8,11,13-tetraene-7-one (1) was deduced by a combination of single crystal X-ray diffraction analysis and the observed Cotton effects in its circular dichroism (CD) spectrum. All isolates were tested for their cytotoxicities against five human cancer cell lines (BGC-823, Huh-7, KB, KE-97, and Jurkat). Among them, compounds 4, 6, 9, 10, 12, and 14, each possessing a common 17(15→16),18(4→3)-diabeo-abietane framework, were found to have remarkable cytotoxic effects with IC50 values ranging from 0.83 to 50.99 μM.
authors: Department of Natural Products Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, People's Republic of China.
authors: Wen-Xuan
authors: WX
authors: Wang
authors: Juan
authors: J
authors: Xiong
authors: Yu
authors: Y
authors: Tang
authors: Jing-Jing
authors: JJ
authors: Zhu
authors: Ming
authors: M
authors: Li
authors: Yun
authors: Y
authors: Zhao
authors: Guo-Xun
authors: GX
authors: Yang
authors: Gang
authors: G
authors: Xia
authors: Jin-Feng
authors: JF
authors: Hu
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D032409:Clerodendrum / Q000737:chemistry*; D006801:Humans; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000970:Antineoplastic Agents