title: Comparative cardiometabolic effects of fibrates and omega-3 fatty acids.
abstract: Even with the aggressive reduction of low-density lipoprotein cholesterol by statin therapy, a high residual risk of cardiovascular events remains substantially and attracts attention to the need for additional preventive therapies. Therefore, effective reductions of residual risk of cardiovascular disease have emerged as therapeutic targets. Fibrates and omega-3 fatty acids have been introduced to reduce triglycerides and to increase high-density lipoprotein cholesterol and have shown anti-atherosclerotic, vascular and metabolic effects. However, some effects are controversial and very recent randomized clinical trials report different results from the earlier ones. In this review, we address the vascular and metabolic effects and the results of recent clinical trials of fibrates and omega-3 fatty acids. We also compared their effects under modern guideline therapy regarding potential drugs to reduce a residual cardiometabolic risk of cardiovascular disease.
authors: Gachon University Gil Medical Center, Incheon, Republic of Korea.
authors: Seung Hwan
authors: SH
authors: Han
authors: Pyung Chun
authors: PC
authors: Oh
authors: Soo
authors: S
authors: Lim
authors: Robert H
authors: RH
authors: Eckel
authors: Kwang Kon
authors: KK
authors: Koh
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000097:blood; D058607:Fibric Acids / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D012307:Risk Factors
chemical_list: D015525:Fatty Acids, Omega-3; D058607:Fibric Acids
keywords: Atherosclerosis; Fibrates; Insulin resistance; Omega-3 fatty acids; Residual cardiovascular risk