title: Curcumin/xanthan-galactomannan hydrogels: rheological analysis and biocompatibility.
abstract: Curcumin, a lipophilic compound found in the plant Curcuma longa L., exhibits a wide range of pharmacological activity; however, its therapeutic use has been limited because of its low bioavailability following oral administration. The aim of this study was to evaluate the viscoelastic characteristics and biocompatibility of a curcumin/xanthan:galactomannan hydrogel (X:G) system after topical application on chick embryo chorioallantoic membrane (CAM), a system established with a view toward curcumin nasal or topical pharmaceutical applications or possible administration in cosmetics or foods. A rheological analysis indicated that incorporation of curcumin did not alter the viscoelastic characteristics of the X:G hydrogel, suggesting that there was no change in the structure of the gel network. X:G hydrogels did not induce CAM tissue injury and the curcumin/X:G hydrogel system was also highly biocompatible. We conclude that the X:G hydrogel represents a potential matrix for curcumin formulations.
authors: Departamento de Bioquímica e Biologia Molecular, UFPR, BP 19046, Centro Politécnico, Cep. 81531-990, Curitiba (PR), Brazil.
authors: Eneida Janiscki
authors: EJ
authors: Da-Lozzo
authors: Ricardo Cambaúva Andrukaisti
authors: RC
authors: Moledo
authors: Cloris Ditzel
authors: CD
authors: Faraco
authors: Claudia Feijó
authors: CF
authors: Ortolani-Machado
authors: Tania Mari Bellé
authors: TM
authors: Bresolin
authors: Joana Léa Meira
authors: JL
authors: Silveira
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000737:chemistry / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry*; D005685:Galactans / Q000737:chemistry; D005690:Galactose / Q000031:analogs & derivatives; D020100:Hydrogels / Q000737:chemistry*; D008351:Mannans / Q000737:chemistry*; D008422:Materials Testing / Q000379:methods*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D053149:Plant Gums / Q000737:chemistry; D011135:Polysaccharides, Bacterial / Q000737:chemistry; D012212:Rheology / Q000379:methods*; D055682:Viscoelastic Substances / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D005685:Galactans; D020100:Hydrogels; D008351:Mannans; D053149:Plant Gums; D011135:Polysaccharides, Bacterial; D055682:Viscoelastic Substances; C012990:galactomannan; D003474:Curcumin; C002563:xanthan gum; C017471:locust bean gum; D005690:Galactose