title: Alteration of lipid status and lipid metabolism, induction of oxidative stress and lipid peroxidation by 2,4-dichlorophenoxyacetic herbicide in rat liver.
abstract: This study aims to investigate the effects of the 2,4-dichlorophenoxyacetic herbicide (2,4-D) on plasma lipids, lipoproteins concentrations, hepatic lipid peroxidation, fatty acid composition and antioxidant enzyme activities in rats. Animals were randomly divided into four groups of 10 each: control group and three 2,4-D-treated groups G1, G2 and G3 were administered 15, 75 and 150 mg/kg/BW/d 2,4-D by gavage for 28 d, respectively. Results showed that 2,4-D caused significant negative changes in the biochemical parameters investigated. The malondialdehyde level was significantly increased in 2,4-D-treated groups. Fatty acid composition of the liver was also significantly changed with 2,4-D exposure. Furthermore, the hepatic antioxidant enzyme activities were significantly affected. Finally, 2,4-D at the studied doses modifies lipidic status, disrupt lipid metabolism and induce hepatic oxidative stress. In conclusion, at higher doses, 2,4-D may play an important role in the development of vascular disease via metabolic disorder of lipoproteins, lipid peroxidation and oxidative stress.
authors: Laboratory of Biochemistry, UR03/ES-08 'Human Nutrition and Metabolic Disorders', Faculty of Medicine, Monastir, Tunisia. tayebwafa2003@yahoo.com
authors: Wafa
authors: W
authors: Tayeb
authors: Amel
authors: A
authors: Nakbi
authors: Imed
authors: I
authors: Cheraief
authors: Abdelhedi
authors: A
authors: Miled
authors: Mohamed
authors: M
authors: Hammami
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000378:metabolism; D006540:Herbicides / Q000737:chemistry / Q000633:toxicity*; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D005227:Fatty Acids; D006540:Herbicides; D008055:Lipids; D015084:2,4-Dichlorophenoxyacetic Acid