title: Aromatic polyketides from a sponge-derived fungus Metarhizium anisopliae mxh-99 and their antitubercular activities.
abstract: In our screening for antitubercular agents, five naphtho-γ-pyrones including two new naphtho-γ-pyrones glycosides, indigotides G and H (1 and 2), and two diphenyl ethers were isolated from the extract of a sponge-derived fungus Metarhizium anisopliae mxh-99. Their structures were established on the basis of chemical and spectroscopic evidence. The antitubercular activities of all the compounds were evaluated against Mycobacterium phlei. The known isochaetochromin B2 (6) and ustilaginoidin D (7) exhibited the highest activity with MICs 50.0 μg/mL.
authors: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
authors: Xianglan
authors: X
authors: Kong
authors: Xinhua
authors: X
authors: Ma
authors: Yunying
authors: Y
authors: Xie
authors: Shengxin
authors: S
authors: Cai
authors: Tianjiao
authors: T
authors: Zhu
authors: Qianqun
authors: Q
authors: Gu
authors: Dehai
authors: D
authors: Li
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D052981:Metarhizium / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009168:Mycobacterium phlei / Q000187:drug effects*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000382:microbiology; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D061065:Polyketides; D011753:Pyrones