title: Therapeutic efficacy of plasmonic photothermal nanoparticles in hamster buccal pouch carcinoma.
abstract: OBJECTIVE
  The objective of this study was to assess the short-term effect of plasmonic photothermal therapy (PPTT) on induced hamster buccal pouch (HBP) carcinoma.
  
  
  METHODS
  Seventy-six Syrian golden male hamsters were used. The induced HBP carcinomas were directly injected with ∼30 nm gold nanospheres followed by 15 min laser exposure (PPTT).
  
  
  RESULTS
  PPTT caused rapid growth cessation and dramatic decrease in tumor sizes after 4 weeks of treatment (P < .05) compared to controls. Microscopic and immunohistochemical examination of the tumor biopsies revealed significant differences in the cellular apoptotic index (AI) value and proliferating cell nuclear antigen (PCNA) immunoexpression in PPTT-treated tumor tissue sections compared to controls (P < .05). Survival probability of the treated animals was increased compared to controls (P < .05).
  
  
  CONCLUSIONS
  PPTT proved to be a successful method for treating superficially located HBP carcinomas.
authors: Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Azarita, Alexandria, Egypt. marwa@gatech.edu
authors: Marwa Mounir
authors: MM
authors: Afifi
authors: Sahar M
authors: SM
authors: El Sheikh
authors: Maha M
authors: MM
authors: Abdelsalam
authors: Heba
authors: H
authors: Ramadan
authors: Taissir A
authors: TA
authors: Omar
authors: Maha
authors: M
authors: El Tantawi
authors: Khaled M
authors: KM
authors: Abdel-Razek
authors: Mostafa
authors: M
authors: Mohamed
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D017209:Apoptosis; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D006224:Cricetinae; D004195:Disease Models, Animal; D006046:Gold / Q000627:therapeutic use*; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D008647:Mesocricetus; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D046529:Microscopy, Electron, Transmission; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D047368:Tumor Burden
chemical_list: D006046:Gold