title: Perfusion deficits in patients with mild traumatic brain injury characterized by dynamic susceptibility contrast MRI.
abstract: Perfusion deficits in patients with mild traumatic brain injury (TBI) from a military population were characterized by dynamic susceptibility contrast perfusion imaging. Relative cerebral blood flow (rCBF) was calculated by a model-independent deconvolution approach from the tracer concentration curves following a bolus injection of gadolinium diethylenetriaminepentaacetate (Gd-DTPA) using both manually and automatically selected arterial input functions (AIFs). Linear regression analysis of the mean values of rCBF from selected regions of interest showed a very good agreement between the two approaches, with a regression coefficient of R = 0.88 and a slope of 0.88. The Bland-Altman plot also illustrated the good agreement between the two approaches, with a mean difference of 0.6 ± 12.4 mL/100 g/min. Voxelwise analysis of rCBF maps from both approaches demonstrated multiple clusters of decreased perfusion (p < 0.01) in the cerebellum, cuneus, cingulate and temporal gyrus in the group with mild TBI relative to the controls. MRI perfusion deficits in the cerebellum and anterior cingulate also correlated (p < 0.01) with neurocognitive results, including the mean reaction time in the Automated Neuropsychological Assessment Metrics and commission error and detection T-scores in the Continuous Performance Test, as well as neurobehavioral scores in the Post-traumatic Stress Disorder Checklist-Civilian Version. In conclusion, rCBF calculated using AIFs selected from an automated approach demonstrated a good agreement with the corresponding results using manually selected AIFs. Group analysis of patients with mild TBI from a military population demonstrated scattered perfusion deficits, which showed significant correlations with measures of verbal memory, speed of reaction time and self-report of stress symptoms.
authors: National Capital Neuroimaging Consortium (NCNC), Bethesda, MD, USA.
authors: Wei
authors: W
authors: Liu
authors: Binquan
authors: B
authors: Wang
authors: Rachel
authors: R
authors: Wolfowitz
authors: Ping-Hong
authors: PH
authors: Yeh
authors: Dominic E
authors: DE
authors: Nathan
authors: John
authors: J
authors: Graner
authors: Haiying
authors: H
authors: Tang
authors: Hai
authors: H
authors: Pan
authors: Jamie
authors: J
authors: Harper
authors: Dzung
authors: D
authors: Pham
authors: Terrence R
authors: TR
authors: Oakes
authors: Louis M
authors: LM
authors: French
authors: Gerard
authors: G
authors: Riedy
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000503:physiopathology* / Q000523:psychology; D002560:Cerebrovascular Circulation; D003071:Cognition; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA