title: Intracranial aneurysms in autosomal dominant polycystic kidney disease.
abstract: OBJECTIVE
  ADPKD correlates with an increased frequency of ICANs, but universal screening for ICANs in patients with ADPKD is not currently recommended. The aim of our study was to determine which groups might benefit from screening by determining the prevalence of ICANs in the Polish ADPKD population and identifying any subgroups with an increased risk for ICANs.
  
  
  METHODS
  Eighty-three adult, predialysis-phase patients with ADPKD underwent screening for ICANs with MRA of the brain.
  
  
  RESULTS
  The prevalence of ICANs in the studied population was 16.9%, with 6% of the screened group requiring neurosurgical intervention. We also found that the frequency of ICANs increases with age, reaching 22.4% in patients older than 45 years. All diagnosed ICANs were small (< 9 mm) and were localized in the anterior circulation. In addition, MR imaging revealed arachnoid cysts in 4.8% of patients with ADPKD.
  
  
  CONCLUSIONS
  We suggest that patients older than 45 years with ADPKD be considered as candidates for screening for ICANs, and we propose a clinical algorithm for this subgroup. However, we could not find risk factors for ICANs in younger patients with ADPKD.
authors: Department of Immunology, Transplant Medicine, and Internal Diseases, Medical University of Warsaw, Warsaw, Poland. mariuszniemczyk@wp.pl
authors: M
authors: M
authors: Niemczyk
authors: M
authors: M
authors: Gradzik
authors: S
authors: S
authors: Niemczyk
authors: M
authors: M
authors: Bujko
authors: M
authors: M
authors: Gołębiowski
authors: L
authors: L
authors: Pączek
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D002532:Intracranial Aneurysm / Q000453:epidemiology* / Q000473:pathology*; D018810:Magnetic Resonance Angiography / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D016891:Polycystic Kidney, Autosomal Dominant / Q000453:epidemiology* / Q000473:pathology*; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D055815:Young Adult