title: [Comparative analysis of gene expression in rat locomotor muscles and diaphragm].
abstract: Gene expression profile in diaphragm in comparison to three principally different hindlimb muscles (soleus, red and white gastrocnemius) was studied using quantitative PCR. Expression levels of PGC-1alpha mRNA and myogenin mRNA in diaphragm were in accordance with its myosin phenotype and citrate synthase activity. However, diaphragm was characterised by atypically high content of MyoD mRNA as well as high content of IGF-1 mRNA and low content of myostatin mRNA. The latter two findings suggest high intensity of protein synthesis in diaphragm muscle fibers, although they have smaller cross sectional area than fibers in locomotor muscles.
authors: A A
authors: AA
authors: Borzykh
authors: D K
authors: DK
authors: Gaĭnullina
authors: I V
authors: IV
authors: Kuz'min
authors: A P
authors: AP
authors: Sharova
authors: O S
authors: OS
authors: Tarasova
authors: O L
authors: OL
authors: Vinogradova
mesh_terms: D000818:Animals; D002950:Citrate (si)-Synthase; D003964:Diaphragm / Q000378:metabolism*; D015870:Gene Expression; D006614:Hindlimb / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D017570:MyoD Protein / Q000096:biosynthesis / Q000235:genetics; D018008:Myogenin / Q000096:biosynthesis / Q000235:genetics; D009218:Myosins / Q000096:biosynthesis / Q000235:genetics; D055435:Myostatin / Q000096:biosynthesis / Q000235:genetics; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D060888:Real-Time Polymerase Chain Reaction; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics
chemical_list: D017570:MyoD Protein; D018008:Myogenin; D055435:Myostatin; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C501429:Ppargc1a protein, rat; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D007334:Insulin-Like Growth Factor I; D002950:Citrate (si)-Synthase; D009218:Myosins