title: Robust spectral-domain optical coherence tomography speckle model and its cross-correlation coefficient analysis.
abstract: In this study, we propose a generic speckle simulation for optical coherence tomography (OCT) signal, by convolving the point-spread function (PSF) of the OCT system with the numerically synthesized random sample field. We validate our model and use the simulation method to study the statistical properties of cross-correlation coefficients between A-scans, which have been recently applied in transverse motion analysis by our group. The results of simulation show that oversampling is essential for accurate motion tracking; exponential decay of OCT signal leads to an underestimate of motion that can be corrected; lateral heterogeneity of sample leads to an overestimate of motion for a few pixels corresponding to the structural boundary.
authors: Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA. xliu35@jhu.edu
authors: Xuan
authors: X
authors: Liu
authors: Jessica C
authors: JC
authors: Ramella-Roman
authors: Yong
authors: Y
authors: Huang
authors: Yuan
authors: Y
authors: Guo
authors: Jin U
authors: JU
authors: Kang
mesh_terms: D008962:Models, Theoretical; D013223:Statistics as Topic; D041623:Tomography, Optical Coherence / Q000379:methods*