title: Plasma Vitamin D Levels And Vitamin D Receptor Polymorphisms Are Associated with Survival of Non-small Cell Lung Cancer.
abstract: OBJECTIVE
  Vitamin D and its receptor (VDR) involve in multiple cellular processes and play an important role in the initiation and progression of malignancy. Thus we hypothesized that plasma vitamin D levels and single nucleotide polymorphisms (SNPs) in VDR may be of prognostic significance in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  We examined plasma 25-hydroxyvitamin D [25(OH)D] levels in 87 patients diagnosed with NSCLC using enzyme-linked immunosorbent assay (ELISA) and genotyped seven potentially functional SNPs in VDR in 568 NSCLC patients on Illumina Golden Gate platform.
  
  
  RESULTS
  Patients with higher plasma 25(OH)D levels had worse survival than patients with lower ones (P for trend = 0.048). The SNPs of rs1544410 and rs739837 were independently associated with NSCLC survival (adjusted HR = 1.61, 95% CIs = 1.06-2.45 for rs739837 AA vs AC/CC and adjusted HR = 1.51, 95% CIs = 1.06-2.16 for rs1544410 AG/AA vs GG). A joint effect was observed between rs1544410 and rs739837 and the risk of death elevated as the number of unfavourable genotypes patients carried increased (P for trend = 0.003). There were no significant associations between VDR polymorphisms and plasma 25(OH)D levels.
  
  
  CONCLUSIONS
  Our findings indicate that plasma 25(OH)D levels and genetic variants of VDR may serve as prognostic markers for NSCLC in this Chinese population.
authors: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
authors: Yao
authors: Y
authors: Liu
authors: Wei
authors: W
authors: Chen
authors: Zhi-Bin
authors: ZB
authors: Hu
authors: Lin
authors: L
authors: Xu
authors: Yong-Qian
authors: YQ
authors: Shu
authors: Shi-Yang
authors: SY
authors: Pan
authors: Jun-Cheng
authors: JC
authors: Dai
authors: Guang-Fu
authors: GF
authors: Jin
authors: Hong-Xia
authors: HX
authors: Ma
authors: Hong-Bing
authors: HB
authors: Shen
keywords: Chinese population; Non-small cell lung cancer; Prognosis; Vitamin D receptor polymorphisms