title: The metalloproteinase ADAMTS1: a comprehensive review of its role in tumorigenic and metastatic pathways.
abstract: As it was first characterized in 1997, the ADAMTS (A Disintegrin and Metalloprotease with ThromboSpondin motifs) metalloprotease family has been associated with many physiological and pathological conditions. Of the 19 proteases belonging to this family, considerable attention has been devoted to the role of its first member ADAMTS1 in cancer. Elevated ADAMTS1 promotes pro-tumorigenic changes such as increased tumor cell proliferation, inhibited apoptosis and altered vascularization. Importantly, it facilitates significant peritumoral remodeling of the extracellular matrix environment to promote tumor progression and metastasis. However, discrepancy exists, as several studies also depict ADAMTS1 as a tumor suppressor. This article reviews the current understanding of ADAMTS1 regulation and the consequence of its dysregulation in primary cancer and ADAMTS1-mediated pathways of cancer progression and metastasis.
authors: Robinson Institute, School of Paediatrics and Reproductive Health, Department of Obstetrics and Gynaecology, Univeristy of Adelaide, South Australia, Australia.
authors: Izza de Arao
authors: Ide A
authors: Tan
authors: Carmela
authors: C
authors: Ricciardelli
authors: Darryl L
authors: DL
authors: Russell
mesh_terms: D051722:ADAM Proteins / Q000235:genetics / Q000378:metabolism*; D000071097:ADAMTS1 Protein; D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D045726:Metalloproteases / Q000235:genetics / Q000378:metabolism*; D009362:Neoplasm Metastasis; D015398:Signal Transduction
chemical_list: D045726:Metalloproteases; D051722:ADAM Proteins; D000071097:ADAMTS1 Protein; C103859:ADAMTS1 protein, human; C486323:Adamts1 protein, mouse
keywords: ADAMTS1; cancer; metalloproteinase; metastasis; pathways