title: The structure of prion: is it enough for interpreting the diverse phenotypes of prion diseases?
abstract: Prion diseases, or transmissible spongiform encephalopathies, are neurodegenerative diseases, which affect human and many species of animals with 100% fatality rate. The most accepted etiology for prion disease is 'prion', which arises from the conversion from cellular PrP(C) to the pathological PrP(Sc). This review discussed the characteristic structure of PrP, including PRNP gene, PrP(C), PrP(Sc), PrP amyloid, and prion strains.
authors: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors: Chan
authors: C
authors: Tian
authors: Xiaoping
authors: X
authors: Dong
mesh_terms: D000682:Amyloid / Q000737:chemistry; D000818:Animals; D006801:Humans; D017096:Prion Diseases / Q000145:classification*; D011328:Prions / Q000737:chemistry* / Q000235:genetics; D011487:Protein Conformation
chemical_list: D000682:Amyloid; D011328:Prions
keywords: PrP; PrP structure; PrPC; prion disease