title: Successful treatment of refractory immune thrombocytopenia with rituximab in a 10-week-old infant.
abstract: Immune thrombocytopenic purpura (ITP) that is unresponsive to conventional treatment is uncommon. In this situation, additional therapeutic options are limited and management is challenging. We describe the case of a 10-week-old infant that developed life-threatening ITP that was unresponsive to immunoglobulin and corticosteroids that was successfully managed with the monoclonal antibody rituximab. The literature on the use of rituximab in nonresponsive ITP is reviewed.
authors: Departments of General Medicine, Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Parkville, VIC, Australia.
authors: Charmaine
authors: C
authors: Gray
authors: Kongolo
authors: K
authors: Kalumba
authors: Nalini
authors: N
authors: Pati
authors: Anna
authors: A
authors: Peterson
authors: Tom G
authors: TG
authors: Connell
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007223:Infant; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000188:drug therapy*; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab