title: Neural substrates of acupuncture in the modulation of cravings induced by smoking-related visual cues: an fMRI study.
abstract: BACKGROUND
  Cue reactivity is a key factor in modulating motivational and goal-directed behaviors associated with compulsive drug intake and relapse. Smoking-associated cues produce smoking urges and cravings and are accompanied by the activation of brain regions involved in attention, motivation, and reward.
  
  
  OBJECTIVE
  We investigated whether acupuncture ameliorates cravings induced by smoking-related visual cues, and we explored the neural mechanisms underlying the effects of acupuncture on modulating smoking urges.
  
  
  METHODS
  After 36 h of smoking abstinence, 25 right-handed male smokers underwent fMRI, during which smoking-related and neutral visual cues were presented. Twelve subjects were treated with real acupuncture (RA) at HT7 and 13 subjects received sham acupuncture (SA). During the scanning sessions, craving scores to smoking-related visual cues were assessed before and after RA or SA treatment. The differences in brain responses to smoking vs. neutral cues after treatment between the RA and SA groups were detected using three-way ANOVAs (Cue × Session × Group).
  
  
  RESULTS
  After treatment, the craving scores were significantly decreased in the RA group, as compared to the SA group. When we explored the neural substrates of acupuncture on the modulation of cravings induced by smoking cues, significant differences were found in the medial prefrontal cortex, the premotor cortex, the amygdala, the hippocampus, and the thalamus.
  
  
  CONCLUSIONS
  These findings suggest that acupuncture alleviates cue-induced cravings through the regulation of activity in brain regions involved in attention, motivation, and reward relative to craving scores in the initial abstinence phase.
authors: Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors: O-Seok
authors: OS
authors: Kang
authors: Song-Yi
authors: SY
authors: Kim
authors: Geon-Ho
authors: GH
authors: Jahng
authors: Hackjin
authors: H
authors: Kim
authors: Jong-Woo
authors: JW
authors: Kim
authors: Sun-Yong
authors: SY
authors: Chung
authors: Jun-Won
authors: JW
authors: Kim
authors: Seung-In
authors: SI
authors: Yang
authors: Hi-Joon
authors: HJ
authors: Park
authors: Hyejung
authors: H
authors: Lee
authors: Younbyoung
authors: Y
authors: Chae
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D000328:Adult; D000704:Analysis of Variance; D001288:Attention; D001921:Brain / Q000378:metabolism; D001931:Brain Mapping; D003463:Cues; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009042:Motivation; D012201:Reward; D012907:Smoking / Q000523:psychology*; D016540:Smoking Cessation / Q000379:methods* / Q000523:psychology; D000074606:Smoking Prevention; D055815:Young Adult