title: Cdc13 at a crossroads of telomerase action.
abstract: Telomere elongation by telomerase involves sequential steps that must be highly coordinated to ensure the maintenance of telomeres at a proper length. Telomerase is delivered to telomere ends, where it engages single-strand DNA end as a primer, elongates it, and dissociates from the telomeres via mechanism that is likely coupled to the synthesis of the complementary C-strand. In Saccharomyces cerevisiae, the telomeric G-overhang bound Cdc13 acts as a platform for the recruitment of several factors that orchestrate timely transitions between these steps. In this review, we focus on some unresolved aspects of telomerase recruitment and on the mechanisms that regulate telomere elongation by telomerase after its recruitment to chromosome ends. We also highlight the key regulatory modifications of Cdc13 that promote transitions between the steps of telomere elongation.
authors: Marseille Cancer Research Center, U1068 INSERM, UMR7258 CNRS, Aix-Marseille University Institut Paoli-Calmettes, Marseille, France.
authors: Dmitri
authors: D
authors: Churikov
authors: Yves
authors: Y
authors: Corda
authors: Pierre
authors: P
authors: Luciano
authors: Vincent
authors: V
authors: Géli
keywords: Cdc13; replication; replication protein A; telomerase; telomeres; yKU70/80