title: Dietary total antioxidant capacity and colorectal cancer: a large case-control study in Italy.
abstract: A favorable role of fruit and vegetables on colorectal cancer risk has been related to the antioxidant properties of their components. We used data from an Italian case-control study including 1,953 patients with incident, histologically confirmed colorectal cancer (1,225 colon and 728 rectal cancers). Controls were 4,154 patients admitted to hospital for acute, non-neoplastic conditions. A reproducible and valid food frequency questionnaire was used to assess subjects' usual diet. Total antioxidant capacity (TAC) was measured using Italian food composition tables in terms of ferric reducing-antioxidant power (FRAP), Trolox equivalent antioxidant capacity (TEAC) and total radical-trapping antioxidant parameter (TRAP). We estimated the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) through multiple logistic regression models, including terms for potential confounding factors, and energy intake. TAC was inversely related with colorectal cancer risk: the OR for the highest versus the lowest quintile was 0.68 (95% CI, 0.57-0.82) for FRAP, 0.69 (95% CI, 0.57-0.83) for TEAC and 0.69 (95% CI, 0.57-0.83) for TRAP. Corresponding values, excluding TAC deriving from coffee, were 0.75 (95% CI, 0.61-0.93) for FRAP, 0.76 (95% CI, 0.61-0.93) for TEAC and 0.71 (95% CI, 0.57-0.89) for TRAP. The inverse association was apparently-though not significantly-stronger for rectal than for colon cancer. This is the first case-control study indicating consistent inverse relations between dietary TAC and colorectal cancer risk.
authors: Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Milan, Italy.
authors: Carlo
authors: C
authors: La Vecchia
authors: Adriano
authors: A
authors: Decarli
authors: Mauro
authors: M
authors: Serafini
authors: Maria
authors: M
authors: Parpinel
authors: Rino
authors: R
authors: Bellocco
authors: Carlotta
authors: C
authors: Galeone
authors: Cristina
authors: C
authors: Bosetti
authors: Antonella
authors: A
authors: Zucchetto
authors: Jerry
authors: J
authors: Polesel
authors: Pagona
authors: P
authors: Lagiou
authors: Eva
authors: E
authors: Negri
authors: Marta
authors: M
authors: Rossi
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D004032:Diet; D005638:Fruit; D006801:Humans; D007558:Italy; D016015:Logistic Models; D016017:Odds Ratio; D012306:Risk; D014675:Vegetables
chemical_list: D000975:Antioxidants
keywords: colorectal cancer; diet; non enzymatic antioxidant capacity; risk; total antioxidant capacity