title: Bisphenol A in relation to behavior and learning of school-age children.
abstract: BACKGROUND
  Bisphenol A (BPA) has been shown to affect brain and behavior in rodents and nonhuman primates, but there are few studies focusing on its relationship to human neurobehavior. We aimed to investigate the relationship between environmental exposure to BPA and childhood neurobehavior.
  
  
  METHODS
  Urinary BPA concentrations and behavioral and learning characteristics were assessed in a general population of 1,089 children, aged 8-11 years. The main outcome measures were the Child Behavior Checklist (CBCL) and the Learning Disability Evaluation Scale (LDES).
  
  
  RESULTS
  Urinary levels of BPA were positively associated with the CBCL total problems score and negatively associated with the learning quotient from the LDES. The linear association with the CBCL anxiety/depression score and the quadratic association with the LDES listening score were significant after correction for multiple comparisons.
  
  
  CONCLUSIONS
  Environmental exposure to BPA might be associated with childhood behavioral and learning development. The results suggest possible nonmonotonic relationships.
authors: Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
authors: Soon-Beom
authors: SB
authors: Hong
authors: Yun-Chul
authors: YC
authors: Hong
authors: Jae-Won
authors: JW
authors: Kim
authors: Eun-Jin
authors: EJ
authors: Park
authors: Min-Sup
authors: MS
authors: Shin
authors: Boong-Nyun
authors: BN
authors: Kim
authors: Hee-Jeong
authors: HJ
authors: Yoo
authors: In-Hee
authors: IH
authors: Cho
authors: Soo-Young
authors: SY
authors: Bhang
authors: Soo-Churl
authors: SC
authors: Cho
mesh_terms: D001559:Benzhydryl Compounds / Q000009:adverse effects* / Q000652:urine; D002648:Child; D002652:Child Behavior / Q000187:drug effects* / Q000523:psychology; D002653:Child Behavior Disorders / Q000139:chemically induced / Q000453:epidemiology / Q000652:urine; D002657:Child Development / Q000187:drug effects; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007858:Learning / Q000187:drug effects*; D007859:Learning Disabilities / Q000139:chemically induced / Q000453:epidemiology / Q000652:urine; D008297:Male; D010287:Parent-Child Relations; D010636:Phenols / Q000009:adverse effects* / Q000652:urine; D056910:Republic of Korea / Q000453:epidemiology; D012574:Schools; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; child behavior; child learning; nonmonotonic dose-response