title: Enzyme-free unlabeled DNA logic circuits based on toehold-mediated strand displacement and split G-quadruplex enhanced fluorescence.
abstract: Adopting fluorescence of PPIX enhanced by a split G-quadruplex and toehold mediated strand displacement reaction, a series of unlabeled fluorescent logic gates is set up and some of them are cascaded into circuits. Controlled release of PPIX, which is also a photosensitizer in photodynamic diagnosis and therapy, is realized by this circuit, making it a wise choice for DNA computing.
authors: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P R China.
authors: Jinbo
authors: J
authors: Zhu
authors: Libing
authors: L
authors: Zhang
authors: Tao
authors: T
authors: Li
authors: Shaojun
authors: S
authors: Dong
authors: Erkang
authors: E
authors: Wang
mesh_terms: D039301:Computers, Molecular; D003850:Deoxyribonuclease I; D004867:Equipment Design; D019544:Equipment Failure Analysis; D054856:G-Quadruplexes / Q000528:radiation effects*; D011524:Protoporphyrins / Q000737:chemistry* / Q000528:radiation effects; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D013050:Spectrometry, Fluorescence / Q000295:instrumentation*
chemical_list: D011524:Protoporphyrins; C028025:protoporphyrin IX; D003850:Deoxyribonuclease I