title: The interleukin-10 promoter polymorphism rs1800872 (-592C>A), contributes to cancer susceptibility: meta-analysis of 16,785 cases and 19,713 controls.
abstract: Interleukin-10 (IL-10) is a multifunctional cytokine which participates in the development and progression of various malignant tumors. To date, a number of case-control studies were conducted to detect the association between IL-10-592C>A polymorphism and cancer risk in humans. However, the results of these studies on the association remain conflicting. In an effort to solve this controversy, we performed a meta-analysis based on 70 case-control studies from 65 articles, including 16 785 cancer cases and 19 713 controls. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The overall results suggested that the variant homozygote genotype AA of the IL-10-592C>A polymorphism was associated with a moderately decreased risk of all cancer types (OR = 0.90, 95% CI = 0.83-0.98 for homozygote comparison, OR = 0.92, 95% CI = 0.86-0.98 for recessive model). In the stratified analyses, the risk remained for studies of smoking-related cancer, Asian populations and hospital-based studies. These results suggested that the IL-10-592C>A polymorphism might contribute to the cancer susceptibility, especially in smoking-related cancer, Asians and hospital-based studies. Further studies are needed to confirm the relationship.
authors: Department of Urology, The Changshu Hospital Affiliated to Soochow University, Changshu, China.
authors: Qi
authors: Q
authors: Ding
authors: Ying
authors: Y
authors: Shi
authors: Bo
authors: B
authors: Fan
authors: Zhijiang
authors: Z
authors: Fan
authors: Li
authors: L
authors: Ding
authors: Feng
authors: F
authors: Li
authors: Wenjian
authors: W
authors: Tu
authors: Xiaohua
authors: X
authors: Jin
authors: Jing
authors: J
authors: Wang
mesh_terms: D016022:Case-Control Studies; D005787:Gene Frequency / Q000235:genetics; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10