title: Infarcted fibroadenoma of the breast: report of two new cases with review of the literature.
abstract: BACKGROUND
  Fibroadenomas are the most common benign breast tumors in young women. Infarction is rarely observed in fibroadenomas and when present, it is usually associated with pregnancy or lactation. Infarction can exceptionally occur as a complication of previous fine-needle aspiration biopsy or during lactation and pregnancy.
  
  
  METHODS
  Retrospective review of 650 cases of fibroadenomas diagnosed at our institution during the 8-years period identified two cases of fibroadenomas with infarction (rate ~0.3%).
  
  
  RESULTS
  Two partially infarcted fibroadenomas were diagnosed on core biopsy and frozen section in an adolescent girl (13 years old) and in a young woman (25 years old), respectively. No preceding fine-needle aspiration biopsy was performed in these cases, nor were the patients pregnant or lactating at the time of the diagnosis.
  
  
  CONCLUSIONS
  Spontaneous infarction within fibroadenoma is a rare phenomenon in younger patients. The presence of necrosis on core biopsy or frozen section should be cautiously interpreted and is not a sign of malignancy.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1556060549847356.
authors: Department of Pathology, Clinical Center of the University of Sarajevo, Bolnička 25, Sarajevo, Bosnia and Herzegovina.
authors: Faruk
authors: F
authors: Skenderi
authors: Fikreta
authors: F
authors: Krakonja
authors: Semir
authors: S
authors: Vranic
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D062005:Biopsy, Large-Core Needle; D001943:Breast Neoplasms / Q000098:blood supply / Q000737:chemistry / Q000473:pathology*; D005260:Female; D018226:Fibroadenoma / Q000098:blood supply / Q000737:chemistry / Q000473:pathology*; D005629:Frozen Sections; D006801:Humans; D007150:Immunohistochemistry; D007238:Infarction / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D011237:Predictive Value of Tests; D016217:Ultrasonography, Mammary
chemical_list: D014408:Biomarkers, Tumor