title: The Colossus of ubiquitylation: decrypting a cellular code.
abstract: Ubiquitylation is an essential posttranslational modification that can regulate the stability, activity, and localization of thousands of proteins. The reversible attachment of ubiquitin as well as interpretation of the ubiquitin signal depends on dynamic protein networks that are challenging to analyze. In this perspective, we discuss tools of the trade that have recently been developed to dissect mechanisms of ubiquitin-dependent signaling, thereby revealing the critical features of an important cellular code.
authors: Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
authors: Adam
authors: A
authors: Williamson
authors: Achim
authors: A
authors: Werner
authors: Michael
authors: M
authors: Rape
mesh_terms: D000818:Animals; D006801:Humans; D011499:Protein Processing, Post-Translational; D055550:Protein Stability; D059748:Proteolysis; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000502:physiology; D057149:Ubiquitinated Proteins / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D057149:Ubiquitinated Proteins; D044767:Ubiquitin-Protein Ligases