title: Clonal multidrug-resistant Corynebacterium striatum within a nosocomial environment, Rio de Janeiro, Brazil.
abstract: Corynebacterium striatum is a potentially pathogenic microorganism with the ability to produce outbreaks of nosocomial infections. Here, we document a nosocomial outbreak caused by multidrug-resistant (MDR) C. striatum in Rio de Janeiro, Brazil. C. striatum identification was confirmed by 16S rRNA and rpoB gene sequencing. Fifteen C. striatum strains were isolated from adults (half of whom were 50 years of age and older). C. striatum was mostly isolated in pure culture from tracheal aspirates of patients undergoing endotracheal intubation procedures. The analysis by pulsed-field gel electrophoresis (PFGE) indicated the presence of four PFGE profiles, including two related clones of MDR strains (PFGE I and II). The data demonstrated the predominance of PFGE type I, comprising 11 MDR isolates that were mostly isolated from intensive care units and surgical wards. A potential causal link between death and MDR C. striatum (PFGE types I and II) infection was observed in five cases.
authors: Laboratório de Difteria e Corinebactérias de Importância Clínica, Departamento de Microbiologia, Imunologia e Patologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors: Paulo Victor Pereira
authors: PV
authors: Baio
authors: Higor Franceschi
authors: HF
authors: Mota
authors: Andréa D'avila
authors: AD
authors: Freitas
authors: Débora Leandro Rama
authors: DL
authors: Gomes
authors: Juliana Nunes
authors: JN
authors: Ramos
authors: Lincoln Oliveira
authors: LO
authors: Sant'Anna
authors: Mônica Cristina
authors: MC
authors: Souza
authors: Thereza Cristina Ferreira
authors: TC
authors: Camello
authors: Raphael
authors: R
authors: Hirata Junior
authors: Verônica Viana
authors: VV
authors: Vieira
authors: Ana Luíza
authors: AL
authors: Mattos-Guaraldi
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D001938:Brazil; D003001:Cloning, Molecular; D003352:Corynebacterium / Q000187:drug effects* / Q000235:genetics; D003354:Corynebacterium Infections / Q000453:epidemiology / Q000382:microbiology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D004269:DNA, Bacterial / Q000235:genetics; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010641:Phenotype; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial