title: Hyper-reactive malarial splenomegaly in the absence of raised IgM antibodies.
abstract: Hyper-reactive malarial splenomegaly (HMS) is diagnosed by the presence of massive splenomegaly, raised IgM and antimalarial antibodies and a response to antimalarial therapy. Although malaria is endemic to Pakistan, HMS is uncommon. We report on HMS in a patient with massive splenomegaly, positive Plasmodium falciparum polymerase chain reaction but normal immunoglobulin M antibody levels. The investigations were not consistent with any other diagnosis. HMS is also briefly reviewed.
authors: Ziauddin University, Karachi, Pakistan.
authors: Mahnur
authors: M
authors: Haider
authors: Sobia
authors: S
authors: Nizami
authors: Adnan
authors: A
authors: Qureshi
authors: Afsheen
authors: A
authors: Raza
authors: Farheen Karim
authors: FK
authors: Mahar
authors: Mohammad Asim
authors: MA
authors: Beg
mesh_terms: D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D016778:Malaria, Falciparum / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D010963:Plasmodium falciparum / Q000235:genetics / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D013163:Splenomegaly / Q000276:immunology*; D055815:Young Adult
chemical_list: D007075:Immunoglobulin M