title: Prediagnostic leptin, adiponectin, C-reactive protein, and the risk of postmenopausal breast cancer.
abstract: Obesity has been associated with an increased risk of postmenopausal breast cancer. Adipokines and systemic inflammation have been hypothesized to underlie this association. In a case-control study nested within the Multiethnic Cohort, conditional logistic regression was used to calculate the ORs and 95% confidence intervals (CI) for postmenopausal breast cancer associated with prediagnostic levels of serum leptin, adiponectin, the leptin:adiponectin ratio, and C-reactive protein (CRP). The 706 cases and 706 controls were matched on ethnicity, location (Hawaii or Los Angeles), birth year, date and time of blood draw, hours fasting before blood draw, and hormone replacement therapy use at blood draw. Higher circulating levels of leptin [ORQ4 vs. Q1, 1.94 (1.37-2.75); Ptrend ≤ 0.001), the leptin:adiponectin ratio [OR, 1.91 (1.36-2.68); Ptrend = 0.005], and CRP [OR, 1.41 (1.01-1.96); Ptrend = 0.014] were associated with an increased risk of postmenopausal breast cancer. The positive associations for these markers remained after adjustment for body mass index (BMI). No associations were detected for adiponectin. These data suggest that adipokines and systemic inflammation may be associated with the risk of postmenopausal breast cancer independently of BMI. Further prospective studies examining the role of adipokines and inflammatory processes in the etiology of postmenopausal breast cancer are warranted. Cancer Prev Res; 6(3); 188-95. ©2013 AACR.
authors: University of Hawaii Cancer Center, Epidemiology Program, 1236 Lauhala St., Honolulu, HI 96813, USA. marc@cc.hawaii.edu
authors: Nicholas J
authors: NJ
authors: Ollberding
authors: Yeonju
authors: Y
authors: Kim
authors: Yurii B
authors: YB
authors: Shvetsov
authors: Lynne R
authors: LR
authors: Wilkens
authors: Adrian A
authors: AA
authors: Franke
authors: Robert V
authors: RV
authors: Cooney
authors: Gertraud
authors: G
authors: Maskarinec
authors: Brenda Y
authors: BY
authors: Hernandez
authors: Brian E
authors: BE
authors: Henderson
authors: Loïc
authors: L
authors: Le Marchand
authors: Laurence N
authors: LN
authors: Kolonel
authors: Marc T
authors: MT
authors: Goodman
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D017698:Postmenopause / Q000097:blood*; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D014408:Biomarkers, Tumor; D020738:Leptin; D002097:C-Reactive Protein