title: Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: incidence, clinicopathological characteristics and prognostic factors.
abstract: Hematopoietic stem cell and solid organ transplant recipients diagnosed with biopsy-confirmed posttransplant lymphoproliferative disorder (PTLD) at our institution from 1989 to 2010 were identified. Patient-, transplant- and disease-related characteristics, prognostic factors and outcome were collected and analyzed. One hundred and forty biopsy-proven cases of PTLD were included. Overall incidence in the transplant population was 2.12%, with heart transplant recipients carrying the highest risk. Most PTLDs were monomorphic (82%), with diffuse large B-cell lymphoma being the most frequent subtype. The majority of cases (70.7%) occurred > 1 year posttransplant, and 66% were Epstein-Barr virus positive. Following initial therapy the overall response rate was 68.5%. Three-year relapse-free and overall survivals were 59% and 49%, respectively. At last follow-up, 44% of the patients were alive. Multivariable analysis identified several classical lymphoma-specific poor prognostic factors for the different outcome measures. The value of the International Prognostic Index was confirmed in our analysis.
authors: Department of Hematology.
authors: Daan
authors: D
authors: Dierickx
authors: Thomas
authors: T
authors: Tousseyn
authors: Xavier
authors: X
authors: Sagaert
authors: Steffen
authors: S
authors: Fieuws
authors: Iwona
authors: I
authors: Wlodarska
authors: Julie
authors: J
authors: Morscio
authors: Lieselot
authors: L
authors: Brepoels
authors: Dirk
authors: D
authors: Kuypers
authors: Johan
authors: J
authors: Vanhaecke
authors: Frederik
authors: F
authors: Nevens
authors: Geert
authors: G
authors: Verleden
authors: Rita
authors: R
authors: Van Damme-Lombaerts
authors: Marleen
authors: M
authors: Renard
authors: Jacques
authors: J
authors: Pirenne
authors: Christiane
authors: C
authors: De Wolf-Peeters
authors: Gregor
authors: G
authors: Verhoef
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult