title: Pan-nitinol occluder and special delivery device for closure of patent ductus arteriosus: a canine-model feasibility study.
abstract: The aim of this study was to evaluate a new type of occluder for patent ductus arteriosus. Patent ductus arteriosus was established in a canine model by anastomosing a length of autologous jugular vein to the descending aorta and the left pulmonary artery in an end-to-side fashion. Transcatheter closure of each patent ductus arteriosus was performed on 10 dogs, which were then monitored for as long as 6 months with aortography, echocardiography, and histologic evaluation. Transcatheter closure with use of the novel pan-nitinol device was successful in all canine models. Postoperative echocardiography showed that the location and shape of the occluders were normal, without any residual shunting. Further histologic evaluation confirmed that the occluder surface was completely endothelialized 3 months after implantation. Transcatheter patent ductus arteriosus closure with the pan-nitinol occluder can be performed safely and successfully in a canine model and shows good biological compatibility and low mortality rates.
authors: Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People's Republic of China.
authors: Hai-bin
authors: HB
authors: Jiang
authors: Yuan
authors: Y
authors: Bai
authors: Gang-jun
authors: GJ
authors: Zong
authors: Lin
authors: L
authors: Han
authors: Wei-ping
authors: WP
authors: Li
authors: Yang
authors: Y
authors: Lu
authors: Yong-wen
authors: YW
authors: Qin
authors: Xian-xian
authors: XX
authors: Zhao
mesh_terms: D000497:Alloys; D000714:Anastomosis, Surgical; D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery; D001027:Aortography; D006328:Cardiac Catheterization / Q000295:instrumentation*; D004195:Disease Models, Animal; D004285:Dogs; D004374:Ductus Arteriosus, Patent / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D004452:Echocardiography; D004867:Equipment Design; D005240:Feasibility Studies; D007601:Jugular Veins / Q000601:surgery; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011651:Pulmonary Artery / Q000601:surgery; D055989:Septal Occluder Device; D013997:Time Factors
chemical_list: D000497:Alloys; C013616:nitinol
keywords: Alloys/administration & dosage; biocompatible materials; disease models, animal; dogs; ductus arteriosus, patent/therapy; heart catheterization/instrumentation/methods; heart septal defects, ventricular/therapy; nitinol/chemistry; prosthesis design; prosthesis implantation/instrumentation/methods; septal occluder device; stainless steel/chemistry