title: Pharmacogenomic approaches for tailored anti-leukemic therapy in children.
abstract: Several lympholytic and cytotoxic agents are used in acute lymphoblastic leukemia (ALL) polychemotherapy. Genetic variants for cellular components involved in the pharmacokinetics and pharmacodynamics of these drugs can influence the pharmacological response, and molecular characterization of these genetic variants could be helpful for the comprehension of the mechanisms of resistance or increased sensitivity. The purpose of this review is to carry out an update of recent publications on genes that might influence ALL treatment in terms of outcome and/or toxicity and to underlie the role of genetic variants, particularly single nucleotide polymorphisms (SNP), in predicting clinical response, with particular reference to the current protocol for ALL therapy used in Italy, AIEOP-BFM ALL 2009.
authors: Department of Life Sciences, University of Trieste, Trieste, Italy. stoccog@units.it
authors: G
authors: G
authors: Stocco
authors: R
authors: R
authors: Franca
authors: F
authors: F
authors: Verzegnassi
authors: M
authors: M
authors: Londero
authors: M
authors: M
authors: Rabusin
authors: G
authors: G
authors: Decorti
mesh_terms: D000470:Alkaloids / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use; D002648:Child; D005938:Glucocorticoids / Q000627:therapeutic use; D006504:Hepatic Veno-Occlusive Disease / Q000188:drug therapy; D006801:Humans; D000068877:Imatinib Mesylate; D015122:Mercaptopurine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D009711:Nucleotides / Q000627:therapeutic use; D010597:Pharmacogenetics; D010879:Piperazines / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011743:Pyrimidines / Q000627:therapeutic use; D013866:Thioguanine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D001549:Benzamides; D005938:Glucocorticoids; D009711:Nucleotides; D010879:Piperazines; D011743:Pyrimidines; D014750:Vincristine; D000068877:Imatinib Mesylate; D015122:Mercaptopurine; D013866:Thioguanine; D008727:Methotrexate