title: Human herpesvirus type 6 DNAemia and infection following allogeneic stem cell transplantation with a focus on long-term outcome.
abstract: Cases of human herpesvirus type 6 (HHV-6) infection and disease were retrospectively analysed in a cohort of 97 allogeneic haematopoietic stem cell transplantation (allo-SCT) patients in Gothenburg, Sweden (1997-2001). Altogether 54 of 97 (56%) patients were tested for HHV-6. HHV-6 DNAemia was detected in 15 of the tested patients at a median of 76 (range 24-387) days after SCT. Nine of these patients were treated against HHV-6 infection and disease for a total of 11 treatment episodes. The morbidity associated with HHV-6 DNAemia following allo-SCT was in most cases moderate. The overall 1-y survival among the patients with HHV-6 DNAemia was 11/15 (73%) and the 5-y survival was 10/15 (67%), which was not significantly different from the whole cohort.
authors: Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. jenny.lindahl@vgregion.se
authors: Jenny K
authors: JK
authors: Lindahl
authors: Susanne
authors: S
authors: Woxenius
authors: Mats
authors: M
authors: Brune
authors: Rune
authors: R
authors: Andersson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019349:Roseolovirus Infections / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D016019:Survival Analysis; D013548:Sweden; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004279:DNA, Viral