title: Pulmonary complications of biological therapies in children and adults with rheumatic diseases.
abstract: The management of rheumatic conditions, including those occurring in children, has improved dramatically over the last decade following the introduction of biologic disease-modifying anti-rheumatic drugs (bDMARDS) into the therapeutic arsenal. The benefits have been realised in multiple aspects of disease including signs and symptoms, bone and cartilage destruction, disability and quality of life. Overall, bDMARDS have an acceptable safety profile in the short to medium term in adults and children, however, that following longer term use remains unclear. As these drugs target key signalling molecules and cells of the immune system, adverse events are not unanticipated. In this review we will discuss pulmonary complications of biologic therapies used in the management of rheumatic diseases in both children and adults.
authors: School of Clinical Medicine, University of Cambridge, Director, Rheumatology Clinical Research Unit, Box 194, Addenbrooke's Hospital, CUHNHSFT, Cambridge CB2 2QQ. Electronic address: drnisar12@yahoo.co.uk.
authors: Muhammad K
authors: MK
authors: Nisar
authors: Andrew J K
authors: AJ
authors: Ostör
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001685:Biological Factors / Q000009:adverse effects* / Q000627:therapeutic use; D001691:Biological Therapy / Q000009:adverse effects*; D002648:Child; D014943:Global Health; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D015994:Incidence; D008171:Lung Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000276:immunology; D012216:Rheumatic Diseases / Q000188:drug therapy* / Q000276:immunology; D055815:Young Adult
chemical_list: D018501:Antirheumatic Agents; D001685:Biological Factors
keywords: Biologics; Complications; ILD; Pulmonary; Safety; bDMARDS