title: Pulsatile hemodynamics and cardiovascular risk factors in very old patients: background, sex aspects and implications.
abstract: BACKGROUND
  In the nineteenth century, prior to the introduction of the cuff sphygmomanometer, stiffening of arteries was recognized as an indicator of vascular ageing and cardiovascular risk. Through the twentieth century, views on vascular ageing came to focus on brachial blood pressures and on occlusive atherosclerotic disease. Such focus deflected attention from primary ageing changes, represented by stiffening and dilation of the proximal aorta.
  
  
  OBJECTIVE
  This review emphasizes the cushioning function of elastic arteries, principally the aorta, now when life expectancy largely exceeds 80 years providing new challenges for medical treatment in the very old.
  
  
  RESULTS
  First, life expectancy has increased significantly for both sexes and is particularly prolonged after menopause. Second, phenotypic changes are noticed such as that the age-related increase of waist circumference and hyperlipidemia is markedly slowed, whereas the concomitant rise in C-reactive protein is enhanced and hyperglycaemia develops in many patients. Third, the systolic, diastolic and pulse pressures rise with age is attenuated or even stopped, as is the degree of arterial stiffness. Finally, in very old patients, the main causes of death are cardiovascular, including cardiac deaths, which differ markedly by causation in men (due to lowered ejection fraction) and women (due to arrhythmia disorders). Deaths associated with renal impairment are observed in both sexes.
  
  
  CONCLUSIONS
  No simple linear relationships exist between all these phenotypic variables and the ageing process. Treatment goals of hypertension and diabetes mellitus remain difficult to predict from such data. Prevention of cardiovascular risk in the very old is thus influenced by limited evidence and important ethical considerations.
authors: Paris-Descartes University, Faculty of Medicine; Hôtel-Dieu Hospital; AP-HP, Diagnosis Center, Paris, France. michel.safar@htd.aphp.fr
authors: Michel E
authors: ME
authors: Safar
authors: Peter M
authors: PM
authors: Nilsson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D005260:Female; D005947:Glucose / Q000378:metabolism; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D011673:Pulsatile Flow; D012307:Risk Factors; D012727:Sex Characteristics; D013599:Systole; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D014280:Triglycerides; D005947:Glucose