title: Structure and biosynthesis of fimsbactins A-F, siderophores from Acinetobacter baumannii and Acinetobacter baylyi.
abstract: Novel chatechol/hydroxamate siderophores (named "fimsbactins") were identified in Acinetobacter baumannii ATCC 17978 and Acinetobacter baylyi ADP1. The major compound, fimsbactin A, was isolated from low-iron cultures of A. baylyi ADP1, and its chemical structure was elucidated by mass spectrometry, and detailed (1)H, (13)C and (15)N NMR spectroscopy. From inverse feeding experiments following HPLC-MS analysis, the structures of five additional derivatives were elucidated. The gene cluster encoding the fimsbactin synthetase (fbs) was identified in both genomes, and mutants in fbs genes in A. baylyi were analyzed, thus allowing prediction of the fimsbactin biosynthesis pathway.
authors: Fachbereich Biowissenschaften, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt am Main, Germany.
authors: Anna
authors: A
authors: Proschak
authors: Patrice
authors: P
authors: Lubuta
authors: Peter
authors: P
authors: Grün
authors: Frank
authors: F
authors: Löhr
authors: Gottfried
authors: G
authors: Wilharm
authors: Veronique
authors: V
authors: De Berardinis
authors: Helge B
authors: HB
authors: Bode
mesh_terms: D000150:Acinetobacter / Q000235:genetics / Q000378:metabolism*; D040981:Acinetobacter baumannii / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002396:Catechols / Q000737:chemistry*; D006877:Hydroxamic Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D005810:Multigene Family; D017262:Siderophores / Q000096:biosynthesis* / Q000737:chemistry
chemical_list: D001426:Bacterial Proteins; D002396:Catechols; D006877:Hydroxamic Acids; D017262:Siderophores; C034221:catechol