title: Clinical effectiveness of comprehensive psychological intervention for nonadherence to medical treatment: a case series.
abstract: OBJECTIVE
  To evaluate the effectiveness of an adherence promotion intervention provided to patients and families referred to a clinical service.
  
  
  METHODS
  6 patients and their caregivers representing 5 different chronic conditions were seen for comprehensive psychological intervention that was evaluated based on electronic monitoring of adherence to prescribed oral medication.
  
  
  RESULTS
  Time series analysis (Auto-Regressive Integrated Moving Average) indicated that for each of the 6 cases, treatment adherence increased during the intervention phase relative to nonintervention periods, but for 5 of these 6 patients, adherence decreased during the follow-up period (p < .05).
  
  
  CONCLUSIONS
  Comprehensive adherence promotion strategies delivered in standard clinical practice were effective, but the effects did not persist after treatment. Future adherence promotion interventions should focus on sustaining intervention effects.
authors: Division of Behavioral Medicine and Clinical Psychology, Center for Promotion of Adherence and Self-Management, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA. sandra.cortina@cchmc.org
authors: Sandra
authors: S
authors: Cortina
authors: Maxx
authors: M
authors: Somers
authors: Jennifer M
authors: JM
authors: Rohan
authors: Dennis
authors: D
authors: Drotar
mesh_terms: D000293:Adolescent; D001521:Behavior Therapy; D002648:Child; D002908:Chronic Disease / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D062405:Motivational Interviewing; D010349:Patient Compliance / Q000523:psychology*
keywords: adherence; chronic illness; clinical significance; intervention outcome