title: Circulating microRNAs levels in Chinese heart failure patients caused by dilated cardiomyopathy.
abstract: BACKGROUND
  Previous studies demonstrated dysregulated expression of microRNAs (miRNAs) in the myocardium of patients with dilated cardiomyopathy (DCM). This study investigated levels of miRNAs in the circulation of DCM patients, and the value of miRNAs as biomarkers for DCM.
  
  
  METHODS
  In 45 DCM patients and 39 age- and sex-matched controls, circulating miR-423-5p, miR-126, miR-361-5p, miR-155, and miR-146a concentrations were measured and correlated to cardiac functional parameters, including left ventricular ejection fraction (LVEF) and N-terminal pro-brain natriuretic peptide (NT-proBNP).
  
  
  RESULTS
  Plasma levels of miR-126 and miR-361-5P did not differ between the DCM and control groups (p = 0.331 and p = 0.784, respectively). Plasma levels of the immunity-associated miRNAs, miR-146a and miR-155, did not differ between the DCM and control groups (p = 0.437 and p = 0.702, respectively). Levels of circulating miR-423-5p were significantly greater in the DCM group (p = 0.003). Further, there was a positive correlation between plasma levels of miR-423-5p and NT-proBNP (r = 0.430, p = 0.003). MiR-423-5p distinguished DCM cases from controls with an area under the curve (AUC) receiver operating characteristic (ROC) curve of 0.674 (95% CI, 0.555-0.793).
  
  
  CONCLUSIONS
  Patients with DCM have elevated plasma miR-423-5p levels. The plasma concentration of miR-423-5p was positively correlated with the level of NT-proBNP. Circulating levels of miR-423-5p could be served as a diagnostic biomarker for heart failure caused by DCM. Plasma levels of immunity-associated miR-146a, -155, and -126 were not significantly different between DCM and control groups.
authors: Department of Cardiology, Nanjing Medical University, Nanjing, China.
authors: Kuan-Lu
authors: KL
authors: Fan
authors: Hai-Feng
authors: HF
authors: Zhang
authors: Jie
authors: J
authors: Shen
authors: Qi
authors: Q
authors: Zhang
authors: Xin-Li
authors: XL
authors: Li
mesh_terms: D000704:Analysis of Variance; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000150:complications*; D016009:Chi-Square Distribution; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000209:etiology*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D012372:ROC Curve
chemical_list: D035683:MicroRNAs; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain