title: A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents.
abstract: BACKGROUND
  Common variants in the FTO locus, and near MC4R locus, have been shown to have a robust association with obesity in children and adults among various ethnic groups. Associations with obesity traits among Indian adolescents have not been determined.
  
  
  OBJECTIVE
  To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents.
  
  
  METHODS
  Subjects for the current study were recruited from a cross-sectional cohort of 1,230 adolescents (age mean ± SD: 17.1 ± 1.9 years) from South India.
  
  
  RESULTS
  The variant at the FTO locus was found to be associated with waist-hip ratio (WHR) but not with overall obesity in this population. No significant association was observed for obesity-traits and Mc4R variant rs17782313.
  
  
  CONCLUSIONS
  The common variant of FTO (rs9939609) is associated with body fat distribution during early growth in Indian adolescents and may predispose to obesity and metabolic consequences in adulthood.
authors: Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine & Surgery, Karolinska Institutet, Stockholm, Sweden. vasan.kandaswamy@ki.se
authors: S K
authors: SK
authors: Vasan
authors: T
authors: T
authors: Fall
authors: V
authors: V
authors: Job
authors: H F
authors: HF
authors: Gu
authors: E
authors: E
authors: Ingelsson
authors: K
authors: K
authors: Brismar
authors: F
authors: F
authors: Karpe
authors: N
authors: N
authors: Thomas
mesh_terms: D000293:Adolescent; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D009765:Obesity / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics*; D010641:Phenotype; D011506:Proteins / Q000235:genetics*; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D049629:Waist-Hip Ratio
chemical_list: D011506:Proteins; D044105:Receptor, Melanocortin, Type 4; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human