title: Acute respiratory distress syndrome due to exposure to high-concentration mixture of ethenone and crotonaldehyde.
abstract: BACKGROUND
  Acute inhalational exposure leads to rapidly progressive acute respiratory distress syndrome (ARDS). This report is the first one to present a patient with ARDS in relation to long-standing exposure to a high-concentration mixture of ethenone and crotonaldehyde.
  
  
  METHODS
  A male worker in a chemical plant was accidentally exposed to the mixture of high-concentrated ethenone and crotonaldehyde for 5 min in an open space and worked continuously in the polluted area for approximately 12 h. On admission, he was conscious with the following vital parameters: blood pressure, 151/91 mmHg; pulse rate, 107 beats/min; respiratory rate, 30 breaths/min; temperature, 37.6°C; oxygen saturation, 92% supported by mask saturation 10 L/min; arterial blood gases showed P/F oxygen ratio of less than 200. Physical examination disclosed decreased bilateral vesicular sounds. A chest computed tomography revealed bilateral nonsegmental ground-glass opacities. The patient was mechanically ventilated and treated with corticosteroid. The patient was discharged without any symptoms.
  
  
  CONCLUSIONS
  Exposure to mixtures of ethenone and crotonaldehyde can cause severe pulmonary injury leading to delayed ARDS.
authors: Department of Critical Care Unit, Zhongshan Hospital, Fu-dan University, Shanghai, China.
authors: Jun-Feng
authors: JF
authors: Huang
authors: Department of Critical Care Unit, Zhongshan Hospital, Fu-dan University, Shanghai, China.
authors: Du-Ming
authors: DM
authors: Zhu
authors: Department of Critical Care Unit, Zhongshan Hospital, Fu-dan University, Shanghai, China.
authors: Jie-Fei
authors: JF
authors: Ma
authors: Department of Critical Care Unit, Zhongshan Hospital, Fu-dan University, Shanghai, China zhong.ming@zs-hospital.sh.cn.
authors: Ming
authors: M
authors: Zhong
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000447:Aldehydes / Q000009:adverse effects*; D005030:Ethylenes / Q000009:adverse effects*; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects; D007659:Ketones / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D015898:Tomography Scanners, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000447:Aldehydes; D005030:Ethylenes; D007659:Ketones; C012796:2-butenal; C008223:ketene
keywords: ARDS; Acute lung injury; acute inhalation injury; acute inhalational exposure; corticosteroid