title: Daily marathon running for a week--the biochemical and body compositional effects of participation.
abstract: Although long-distance running, such as ultramarathons and multistage races, is increasingly popular, it maybe potentially harmful to health, despite sparse evidence. We studied 8 experienced recreational runners participating in a multiple-marathon running event in which 7 marathons were completed on consecutive days. Fasting blood chemistry and body composition were assessed before and 20-24 hours after the race. The total finish time for the 7 marathons ranged between 23:25:42 and 34:25:21 (hours:minutes:seconds). Only minor increases in circulating skeletal muscle cell damage markers, liver cell damage markers, and inflammatory markers occurred after the race. No other significant adverse biochemical effects were observed. The homeostasis model assessment of insulin resistance decreased markedly, and an improved lipid profile was found. A decrease in fat mass and increase in lean body mass was observed, resulting in no overall weight changes. In summary, the race did not cause any major adverse effects, whereas some traditional markers of cardiovascular disease improved acutely after the race.
authors: The Center of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: Kristian
authors: K
authors: Karstoft
authors: Thomas P
authors: TP
authors: Solomon
authors: Matthew J
authors: MJ
authors: Laye
authors: Bente K
authors: BK
authors: Pedersen
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001779:Blood Coagulation Factors / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D005215:Fasting; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008049:Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood; D009961:Orosomucoid / Q000378:metabolism; D012420:Running / Q000502:physiology*; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D015415:Biomarkers; D001779:Blood Coagulation Factors; D001786:Blood Glucose; D006454:Hemoglobins; D007328:Insulin; D009211:Myoglobin; D009961:Orosomucoid; D012709:Serum Albumin; D002097:C-Reactive Protein; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008049:Lipase