title: [Clinical features and therapeutic response of aplastic anemia patients with or without cytogenetic abnormalities].
abstract: OBJECTIVE
  To compare clinical features and therapeutic response of patients with aplastic anemia with and without cytogenetic abnormalities.
  
  
  METHODS
  Clinical features of 133 patients with successful chromosomal analysis were retrospectively studied, and therapeutic response between patients with and without cytogenetic abnormalities was compared.
  
  
  RESULTS
  Cytogenetic abnormalities were found in 9 patients, which included trisomy 8 (4 cases), monosomy 7 (2 cases) and Xq- (1 case), 1q- (1 case) and 7q- (1 case). No significant difference was detected between patients with or without cytogenetic abnormalities in terms of age (50 vs. 58, P=0.337), sex ratio (male 55.56% vs. 62.10%, female 44.44% vs. 37.90%, P=0.762), or episode of acute aplastic anemia (44.44% vs. 37.10%, P=0.728). Patients with cytogenetic abnormalities had a tendency towards poorer rate of therapeutic response, which was however not significantly different from those without (55.56% vs. 79.03%, P=0.116). All of the 4 patients with +8 responded to treatment, whilst none of those with -7 or 7q- did.
  
  
  CONCLUSIONS
  No significant difference was found between aplastic anemia patients with or without cytogenetic abnormalities in terms of clinical features and therapeutic response. Patients with trisomy 8 seem to have a favorable response towards treatment.
authors: Institute of Hematopathy, People's Hospital of Henan Province, Zhengzhou, Henan, People's Republic of China.
authors: Yu-long
authors: YL
authors: Li
authors: Lu-she
authors: LS
authors: Liu
authors: Ya-ping
authors: YP
authors: Zhai
authors: Wei
authors: W
authors: Cheng
authors: Lu-fang
authors: LF
authors: Zhang
authors: Yin
authors: Y
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000235:genetics* / Q000628:therapy*; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult