title: Asthma drugs and the risk of congenital anomalies.
abstract: OBJECTIVE
  To estimate the prevalence of congenital anomalies between the offspring of women exposed and unexposed to asthma drugs during early pregnancy.
  
  
  METHODS
  Matched cohort study.
  
  
  METHODS
  The United Kingdom's General Practice Research Database.
  
  
  METHODS
  Women exposed to asthma drugs during early pregnancy and a sample of matched unexposed pregnant women.
  
  
  RESULTS
  The prevalence of any anomaly among unexposed and exposed women was 27.8 (95% confidence interval [CI] 25.4-30.6)/1000 pregnancies and 31.3 (95% CI 27.7-35.5)/1000 pregnancies, respectively (relative risk [RR] 1.1 95% CI 1.0-1.3).
  
  
  CONCLUSIONS
  Our findings suggest that asthma drugs, overall, do not increase the risk of congenital anomalies in the offspring when taken during the first trimester of pregnancy.
authors: Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
authors: Catherine
authors: C
authors: Vasilakis-Scaramozza
authors: Ann
authors: A
authors: Aschengrau
authors: Howard J
authors: HJ
authors: Cabral
authors: Susan S
authors: SS
authors: Jick
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D015995:Prevalence; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D018927:Anti-Asthmatic Agents