title: Function of Arabidopsis CPL1 in cadmium responses.
abstract: Transcriptional and post-transcriptional responses to external iron (Fe) availability are essential for the cellular Fe homeostasis. Fe deficiency strongly induces Fe utilization-related gene expression; however, little is known about the early Fe signaling that regulates expression of a central transcription factor FIT. In Arabidopsis, mutations in RNA polymerase II CTD-phosphatase-like 1 (CPL1) enhance the expression of Fe utilization-related genes including FIT under Fe deficiency. Fe content is significantly increased in the roots and decreased in the shoots of cpl1-2 plants, and root growth of the cpl1-2 mutant shows higher tolerance to Fe deficiency and to toxicity of cadmium (Cd). The cpl1-2 plants accumulate more Cd in the shoots, suggesting that Cd toxicity in the cpl1-2 roots is circumvented by the transport of excess Cd to the shoots. Here we show data suggesting that the root-to-shoot translocation of Cd in cpl1-2 is mediated by yet uncharacterized Cd transport mechanisms.
authors: Molecular and Environmental Plant Sciences; Vegetable and Fruit Development Center; Department of Horticultural Sciences; Texas A&M University; College Station, TX USA.
authors: Emre
authors: E
authors: Aksoy
authors: Hisashi
authors: H
authors: Koiwa
mesh_terms: D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D002104:Cadmium / Q000633:toxicity*; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D026901:Membrane Transport Proteins; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D002104:Cadmium; C465438:CPL1 protein, Arabidopsis; D010749:Phosphoprotein Phosphatases
keywords: CPL1; CTD; FIT; FRO2; IRT1; cadmium; iron; signaling; stress; transcription