title: Distribution of 2-deoxy-2-fluoro-d-glucose in the coelom of healthy bald eagles (Haliaeetus leucocephalus).
abstract: OBJECTIVE
  To determine 2-deoxy-2-fluoro (fluorine 18)-d-glucose ((18)FDG) biodistribution in the coelom of bald eagles (Haliaeetus leucocephalus).
  
  
  METHODS
  8 healthy adult bald eagles.
  
  
  METHODS
  For each eagle, whole-body transmission noncontrast CT, 60-minute dynamic positron emission tomography (PET) of the celomic cavity (immediately after (18)FDG injection), whole-body static PET 60 minutes after (18)FDG injection, and whole-body contrast CT with iohexol were performed. After reconstruction, images were analyzed. Regions of interest were drawn over the ventricular myocardium, liver, spleen, proventriculus, cloaca, kidneys, and lungs on dynamic and static PET images. Standardized uptake values were calculated.
  
  
  RESULTS
  Kidneys had the most intense (18)FDG uptake, followed by cloaca and intestinal tract; liver activity was mild and slightly more intense than that of the spleen; proventricular activity was always present, whereas little to no activity was identified in the wall of the ventriculus. Activity in the myocardium was present in all birds but varied in intensity among birds. The lungs had no visibly discernible activity. Mean ± SD standardized uptake values calculated with representative regions of interest at 60 minutes were as follows: myocardium, 1. 6 ± 0.2 (transverse plane) and 1.3 ± 0.3 (sagittal plane); liver, 1.1 ± 0.1; spleen, 0.9 ± 0.1; proventriculus, 1.0 ± 0.1; cloaca, 4.4 ± 2.7; right kidney, 17.3 ± 1.0; left kidney, 17.6 ± 0.3; and right and left lungs (each), 0.3 ± 0.02.
  
  
  CONCLUSIONS
  The study established the biodistribution of (18)FDG in adult eagles, providing a baseline for clinical investigation and future research.
authors: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA. mpjones@utk.edu
authors: Michael P
authors: MP
authors: Jones
authors: Federica
authors: F
authors: Morandi
authors: Jonathan S
authors: JS
authors: Wall
authors: Misty J
authors: MJ
authors: Long
authors: Alan C
authors: AC
authors: Stuckey
authors: Amy K
authors: AK
authors: LeBlanc
mesh_terms: D000818:Animals; D020307:Eagles / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D049268:Positron-Emission Tomography / Q000662:veterinary; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed / Q000662:veterinary
chemical_list: D019788:Fluorodeoxyglucose F18