title: Nasolacrimal system obstruction, ptosis and esotropia due to chemotherapy in acute lymphoblastic leukemia.
abstract: Eight-year-old girl was admitted to our clinic with the complaint of constant epiphora in the right eye. It was reported that this complaint began after the start of chemotherapy with a diagnosis of Acute Lymphoblastic Leukemia (ALL) about 5 years ago. In addition, eyelid ptosis associated with esotropia also occurred during that period. We found that nasolacrimal duct obstruction did not improve with medical treatment but ptosis and esotropia improved with pyridoxine and pyridostigmine treatment during that period. Examination of the eye on admission revealed nasolacrimal duct obstruction on the right side. Other ocular findings were normal. Nasolacrimal system obstruction, ptosis and esotropia combination has not been reported previously in patients using systemic drugs or receiving chemotherapy due to ALL.
authors: Department of Ophthalmology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
authors: Oktay
authors: O
authors: Esmer
authors: Remzi
authors: R
authors: Karadag
authors: Erkan
authors: E
authors: Soylu
authors: Ahmet Faik
authors: AF
authors: Oner
authors: Evren
authors: E
authors: Burakgazi-Dalkilic
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001215:Asparaginase / Q000008:administration & dosage; D001763:Blepharoptosis / Q000139:chemically induced*; D002648:Child; D003630:Daunorubicin / Q000008:administration & dosage; D004948:Esotropia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000139:chemically induced*; D008727:Methotrexate / Q000008:administration & dosage; D009301:Nasolacrimal Duct; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D011239:Prednisolone; D001215:Asparaginase; D008727:Methotrexate; D003630:Daunorubicin