title: Retinal nerve fiber layer thickness in children <18 years by spectral-domain optical coherence tomography.
abstract: OBJECTIVE
  To establish a normative database for retinal nerve fiber layer (RNFL) thickness in children<18 years by spectral-domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  Children <18 years, who were consecutively enrolled from July-August 2011 in this cross-sectional hospital study, underwent Cirrus SD-OCT. Recorded demographics and clinical characteristics included age, sex, axial length, spherical equivalent, intraocular pressure (by Perkins tonometry) and cup disc ratio. The RNFL thickness full circle (RNFL-FC), superior, (RNFL-S), inferior (RNFL-I), temporal (RNFL-T), and nasal (RNFL-N) and the influence of clinical and demographic factors on the RNFL thickness were assessed using linear regression analysis.
  
  
  RESULTS
  148 eyes of 74 children were analyzed (females: males = 37: 37) with a mean age of 10 ± 3.4 years (range 4-17 years) and a mean spherical equivalent of -0.6 ± 1.2 dioptres. The mean RNFL-FC was 94 ± 10.9 and 93 ± 10.6 µm in the right and left eyes, respectively, with maximum thickness found in the superior quadrant. The RNFL-FC and RNFL-S decreased by 1.9 µm for every 1 dioptre increase in myopic shift, p < 0.001, and by 1.9 µm for every mm increase in axial length, p < 0.001. There was no effect of age on RNFL thickness in females or males.
  
  
  CONCLUSIONS
  The RNFL thickness in children was influenced most by axial length and refractive error while it was independent of age. The normative data from this study could serve as reference for further studies on pediatric glaucoma using newer imaging devices.
authors: Glaucoma Services, LV Prasad Eye Institute, Patia, Bhubaneswar, Orissa, India. vinodini10375@yahoo.com
authors: Aparna
authors: A
authors: Rao
authors: Bhaktiprada
authors: B
authors: Sahoo
authors: Mukesh
authors: M
authors: Kumar
authors: Gopal
authors: G
authors: Varshney
authors: Ramesh
authors: R
authors: Kumar
mesh_terms: D000293:Adolescent; D000375:Aging / Q000502:physiology*; D058452:Axial Length, Eye / Q000033:anatomy & histology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009412:Nerve Fibers; D009900:Optic Nerve / Q000033:anatomy & histology*; D012016:Reference Values; D012165:Retinal Ganglion Cells / Q000166:cytology*; D041623:Tomography, Optical Coherence