title: Lymphoepithelioma-like gastric carcinoma: an unusual consequence of Epstein-Barr virus infection in an HIV-infected woman.
abstract: Lymphoepithelioma-like-gastric carcinoma (LEL-GC) is an Epstein-Barr virus (EBV)-associated neoplasm of the stomach reported to have a better prognosis than conventional gastric adenocarcinoma. Unlike other EBV-associated malignancies, particularly lymphoproliferative disorders and undifferentiated nasopharyngeal carcinoma, for which risk has been shown to increase in human immunodeficiency virus (HIV) infection, LEL-GC remains rare; only one HIV-infected patient with LEL-GC has been reported previously. We describe an aggressive case of EBV-associated LEL-GC in a woman co-infected with HIV 1 and hepatitis C virus. In situ hybridization of an endoscopic biopsy specimen for EBV-encoded small RNA confirmed the presence of this agent exclusively in the gastric cancer cells. Our patient had recently started antiretroviral therapy, suggesting that immune reconstitution may have been a factor in presentation of this tumour.
authors: Department of Pathology and Laboratory Medicine, St Luke's-Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, NY, USA.
authors: P
authors: P
authors: Paniz-Mondolfi
authors: Y
authors: Y
authors: Pang
authors: S
authors: S
authors: Cohen
authors: J
authors: J
authors: Balderacchi
authors: L
authors: L
authors: Tsveniashvili
authors: B
authors: B
authors: Polsky
authors: E M
authors: EM
authors: Sordillo
mesh_terms: D000386:AIDS-Related Complex / Q000188:drug therapy / Q000473:pathology; D000230:Adenocarcinoma / Q000473:pathology / Q000821:virology; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D015497:HIV-1; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications; D008232:Lymphoproliferative Disorders / Q000188:drug therapy / Q000473:pathology; D009367:Neoplasm Staging; D012367:RNA, Viral / Q000032:analysis; D013274:Stomach Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000821:virology*; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D012367:RNA, Viral
keywords: AIDS; EBV; Epstein–Barr virus; HIV; lymphoepithelioma-like gastric carcinoma; malignancy