title: A chronic leg ulcer presenting with Charcot-Marie-Tooth disease and type 2 diabetes: a case report.
abstract: Charcot-Marie-Tooth (CMT) disease is characterized by hereditary sensorimotor polyneuropathy with foot deformity, sensorineural hearing loss, moderate developmental delay, and gait disturbance. CMT presenting with type 2 diabetes and an ulcer has not been reported. This article reports a man who presented with the symptoms mentioned above and also with a leg ulcer and type 2 diabetes. He was diagnosed with CMT disease based on family history and genetic testing. A skin defect in the left leg had manifested for more than 1 year, and results of initial fasting plasma glucose revealed type 2 diabetes. The evolution of these manifestations, coupled with a slowly progressive weakness, numbness, muscular wasting, and sensory impairment, strongly suggested the co-occurrence of 3 different diseases in the same individual.
authors: Zhejiang University, Hangzhou, People's Republic of China.
authors: Haitao
authors: H
authors: Ren
authors: Chuangang
authors: C
authors: You
authors: Chunmao
authors: C
authors: Han
mesh_terms: D000284:Administration, Oral; D002607:Charcot-Marie-Tooth Disease / Q000150:complications*; D003646:Debridement / Q000379:methods*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005500:Follow-Up Studies; D006801:Humans; D007871:Leg Ulcer / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014803:Vitamin B Complex