title: Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain.
abstract: Peptoid libraries have been shown to be a useful source of protein-binding agents. However, simple linear peptoids lack conformational constraints, which may limit their binding affinity for proteins. Here we report facile chemistry for the assembly of 2-oxopiperazine rings into the main chain of peptoid-like oligomers, thus rigidifying the structure. This modified sub-monomer synthesis is suitable for the creation of high quality combinatorial libraries.
authors: Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA.
authors: Sujit
authors: S
authors: Suwal
authors: Thomas
authors: T
authors: Kodadek
mesh_terms: D015394:Molecular Structure; D019151:Peptide Library; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010879:Piperazines / Q000737:chemistry*
chemical_list: D019151:Peptide Library; D057786:Peptidomimetics; D010879:Piperazines