title: IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells.
abstract: Here, we show that interleukin-1 (IL-1) enhances antigen-driven CD8 T cell responses. When administered to recipients of OT-I T cell receptor transgenic CD8 T cells specific for an ovalbumin (OVA) peptide, IL-1 results in an increase in the numbers of wild-type but not IL1R1(-/-) OT-I cells, particularly in spleen, liver, and lung, upon immunization with OVA and lipopolysaccharide. IL-1 administration also results in an enhancement in the frequency of antigen-specific cells that are granzyme B(+), have cytotoxic activity, and/ or produce interferon γ (IFN-γ). Cells primed in the presence of IL-1 display enhanced expression of granzyme B and increased capacity to produce IFN-γ when rechallenged 2 mo after priming. In three in vivo models, IL-1 enhances the protective value of weak immunogens. Thus, IL-1 has a marked enhancing effect on antigen-specific CD8 T cell expansion, differentiation, migration to the periphery, and memory.
authors: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Shlomo Z
authors: SZ
authors: Ben-Sasson
authors: Alison
authors: A
authors: Hogg
authors: Jane
authors: J
authors: Hu-Li
authors: Paul
authors: P
authors: Wingfield
authors: Xi
authors: X
authors: Chen
authors: Michelle
authors: M
authors: Crank
authors: Stephane
authors: S
authors: Caucheteux
authors: Maya
authors: M
authors: Ratner-Hurevich
authors: Jay A
authors: JA
authors: Berzofsky
authors: Ran
authors: R
authors: Nir-Paz
authors: William E
authors: WE
authors: Paul
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D005260:Female; D007114:Immunization; D007156:Immunologic Memory / Q000187:drug effects*; D007371:Interferon-gamma / Q000096:biosynthesis; D007375:Interleukin-1 / Q000494:pharmacology*; D008089:Listeria monocytogenes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL
chemical_list: D007375:Interleukin-1; D007371:Interferon-gamma