title: Risk factors for death in HIV-infected adult African patients receiving anti-retroviral therapy.
abstract: OBJECTIVE
  To determine risk factors for death in HIV-infected African patients on anti-retroviral therapy (ART).
  
  
  METHODS
  Retrospective Case-control study.
  
  
  METHODS
  The MOH-USAID-AMPATH Partnership ambulatory HIV-care clinics in western Kenya.
  
  
  RESULTS
  Between November 2001 and December 2005 demographic, clinical and laboratory data from 527 deceased and 1054 living patients receiving ART were compared to determine independent risk factors for death. Median age at ART initiation was 38 versus 36 years for the deceased and living patients respectively (p<0.0148). Median time from enrollment at AMPATH to initiation of ART was two weeks for both groups while median time on ART was eight weeks for the deceased and fourty two weeks for the living (p<0.0001). Patients with CD4 cell counts <100/mm3 were more likely to die than those with counts >100/mm3 (HR=1.553. 95% CI (1.156, 2.087), p<0.003). Patients attending rural clinics had threefold higher risk of dying compared to patients attending clinic at a tertiary referral hospital (p<0.0001). Two years after initiating treatment fifty percent of non-adherent patients were alive compared to 75% of adherent patients. Male gender, WHO Stage and haemoglobin level <10 grams% were associated with time to death while age, marital status, educational level, employment status and weight were not.
  
  
  CONCLUSIONS
  Profoundly immunosuppressed patients were more likely to die early in the course of treatment. Also, patients receiving care in rural clinics were at greater risk of dying than those receiving care in the tertiary referral hospital.
authors: Department of Medicine, Moi University School of Medicine, P. O. Box 4606 - 30100, Eldoret, Kenya.
authors: A M
authors: AM
authors: Siika
authors: K
authors: K
authors: Wools-Kaloustian
authors: A W
authors: AW
authors: Mwangi
authors: S N
authors: SN
authors: Kimaiyo
authors: L O
authors: LO
authors: Diero
authors: P O
authors: PO
authors: Ayuo
authors: W D
authors: WD
authors: Owino-Ong'or
authors: J E
authors: JE
authors: Sidle
authors: R M
authors: RM
authors: Einterz
authors: C T
authors: CT
authors: Yiannoutsos
authors: B
authors: B
authors: Musick
authors: W M
authors: WM
authors: Tierney
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000401:mortality*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012189:Retrospective Studies; D012307:Risk Factors; D019035:Rural Health Services; D012737:Sex Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents; D006454:Hemoglobins