title: Corneal thickness and volume measurements by swept source anterior segment optical coherence tomography in normal subjects.
abstract: OBJECTIVE
  To evaluate central corneal thickness (CCT) and corneal volume (CV) in healthy eyes using swept source anterior segment optical coherence tomography (SS-AS-OCT) and other devices.
  
  
  METHODS
  Thirty-three healthy right eyes of 33 subjects were investigated. CCT was measured with SS-AS-OCT, rotating Scheimpflug camera, ultrasonic pachymetry and specular microscopy. CV was determined within a diameter of 10 mm at the center using SS-AS-OCT and Scheimpflug camera.
  
  
  RESULTS
  Mean CCT was 523.5 ± 25.2 μm by SS-AS-OCT, 523.9 ± 26.1 μm by Scheimpflug camera, 532.1 ± 26.6 μm by ultrasonic pachymetry, and 525.5 ± 33.5 μm by specular microscopy. The CCTs measured with SS-AS-OCT, Scheimpflug camera and specular microscopy were significantly thinner than those measured with ultrasonic pachymeter (p < 0.001). The mean CV within a diameter of 10 mm at the center was 57.2 ± 3.0 mm(3) by SS-AS-OCT and 59.4 ± 2.9 mm(3) by Scheimpflug camera. Scheimpflug measurements of CV were statistically larger than SS-AS-OCT measurements (p = 0.0008). Statistically significant correlation was found between the CCT and CV measurements of each imaging devices (p < 0.0001, r = 0.527, and p < 0.0001, r = 0.749, respectively).
  
  
  CONCLUSIONS
  SS-AS-OCT enables the measurements of CCT and CV, demonstrating agreement with other devices. CV in addition to CCT measurement may serve as a practical parameter of the corneal endothelial pump function.
authors: Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan.
authors: Reina
authors: R
authors: Fukuda
authors: Tomohiko
authors: T
authors: Usui
authors: Takashi
authors: T
authors: Miyai
authors: Yosai
authors: Y
authors: Mori
authors: Kazunori
authors: K
authors: Miyata
authors: Shiro
authors: S
authors: Amano
mesh_terms: D000293:Adolescent; D000328:Adult; D000869:Anterior Eye Segment / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D003315:Cornea / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D063171:Corneal Pachymetry / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010781:Photography / Q000295:instrumentation / Q000592:standards*; D012016:Reference Values; D041623:Tomography, Optical Coherence / Q000592:standards*; D014463:Ultrasonography; D055815:Young Adult