title: GSK-3β polymorphism discriminates bipolar disorder and schizophrenia: a systematic meta-analysis.
abstract: Glycogen synthase kinase 3 (GSK-3) is a well-known conserved and ubiquitous protein kinase and playing a pivotal role in neurodevelopment, neurogenesis, learning/memory, and neuronal cell death. Dysfunction of GSK-3 had been seen in multiple neurodegenerative and psychiatric diseases. Bipolar disorder and schizophrenia are two common psychiatric diseases first occur in adolescence or young adulthood. They share similar risk genes as well as clinical symptoms, which make it is difficult to be discriminated from each other. Here, by using meta-analysis we reported that glycogen synthase kinase 3β promoter inactive mutant rs334558 may contribute to the development of schizophrenia not bipolar disorder. This might be used to distinguish these two diseases.
authors: Department of Pathophysiology, Basic Medical School, Hangkong Road No. 13, Wuhan, 430030, People's Republic of China.
authors: Hui
authors: H
authors: Tang
authors: Na
authors: N
authors: Shen
authors: Huijuan
authors: H
authors: Jin
authors: Dan
authors: D
authors: Liu
authors: Xiaoping
authors: X
authors: Miao
authors: Ling-Qiang
authors: LQ
authors: Zhu
mesh_terms: D001714:Bipolar Disorder / Q000201:enzymology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017594:Publication Bias; D012307:Risk Factors; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics*
chemical_list: C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3