title: Perinatal outcomes in 375 children born after oocyte donation: a Danish national cohort study.
abstract: OBJECTIVE
  To describe perinatal outcomes in children born after oocyte donation (OD) compared with in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and spontaneous conception (SC).
  
  
  METHODS
  National cohort study.
  
  
  METHODS
  Fertility clinics.
  
  
  METHODS
  Three hundred seventy-five children born after OD during the period 1995-2010.
  
  
  METHODS
  None.
  
  
  METHODS
  Mean birth weight, mean gestational age, risks of low birth weight (LBW), preterm birth (PTB), congenital malformations, cesarean delivery, preeclampsia, and admittance to neonatal intensive care unit.
  
  
  RESULTS
  We found an increased risk of PTB in OD pregnancies. The adjusted odds ratio (AOR) of PTB in OD singletons was 1.8 (95% CI, 1.2-2.69), 2.5 (95% CI, 1.7-3.6), and 3.4 (95% CI, 2.3-4.9) compared with IVF, ICSI, and SC, respectively. The risk of LBW was also increased. The AOR of LBW was 1.4 (95% CI, 0.9-2.2), 1.8 (95% CI, 1.2-2.8), and 2.6 (95% CI, 1.7-4.0) compared with IVF, ICSI, and SC. The risk of preeclampsia was increased in OD pregnancies with an AOR of 2.9 (95% CI, 1.8-4.6), 2.8 (95% CI, 1.7-4.5), and 3.1 (95% CI, 1.9-4.9) compared with IVF, ICSI, and SC. After additional adjustment for preeclampsia, perinatal outcome improved. Among the twins, the difference between the groups was less pronounced.
  
  
  CONCLUSIONS
  Pregnancies after OD have a poorer perinatal outcome than those after standard IVF and ICSI mainly because of the high prevalence of preeclampsia.
authors: Fertility Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. smalchau@hotmail.com
authors: Sara S
authors: SS
authors: Malchau
authors: Anne
authors: A
authors: Loft
authors: Elisabeth C
authors: EC
authors: Larsen
authors: Anna-Karina
authors: AK
authors: Aaris Henningsen
authors: Steen
authors: S
authors: Rasmussen
authors: Anders Nyboe
authors: AN
authors: Andersen
authors: Anja
authors: A
authors: Pinborg
mesh_terms: D000328:Adult; D002648:Child; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018587:Oocyte Donation / Q000379:methods / Q000639:trends*; D018743:Perinatal Care / Q000379:methods / Q000639:trends*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*