title: Selective, sensitive, and rapid analysis with lateral-flow assays based on antibody-gated dye-delivery systems: the example of triacetone triperoxide.
abstract: Set them free: Brightly fluorescent indicators that are loaded into mesoporous silica nanoparticle carriers, capped with bulky antibodies, are released into the lateral flow of a test strip upon analyte arrival. Integration of the system into a rapid, simple flow test with fluorescence readout is applied for the selective and sensitive determination of the presence of triacetone triperoxide (TATP) as a prototype small-molecule analyte (see figure).
authors: Centro de Reconocimienro Molecular y Desarrollo Tecnológico (IDM), Unidad mixta Universitat Politècnica de València, Universitat de València, Departamento de Química, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022 Valencia, Spain.
authors: Estela
authors: E
authors: Climent
authors: Delia
authors: D
authors: Gröninger
authors: Mandy
authors: M
authors: Hecht
authors: M Astrid
authors: MA
authors: Walter
authors: Ramón
authors: R
authors: Martínez-Máñez
authors: Michael G
authors: MG
authors: Weller
authors: Félix
authors: F
authors: Sancenón
authors: Pedro
authors: P
authors: Amorós
authors: Knut
authors: K
authors: Rurack
mesh_terms: D000906:Antibodies / Q000032:analysis*; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes; D006573:Heterocyclic Compounds, 1-Ring / Q000008:administration & dosage / Q000032:analysis*; D008956:Models, Chemical; D053758:Nanoparticles / Q000032:analysis*; D010545:Peroxides / Q000008:administration & dosage / Q000032:analysis*; D012235:Rhodamines; D012822:Silicon Dioxide / Q000032:analysis*
chemical_list: D000906:Antibodies; D005456:Fluorescent Dyes; D006573:Heterocyclic Compounds, 1-Ring; D010545:Peroxides; D012235:Rhodamines; C495284:triacetone triperoxide; D012822:Silicon Dioxide