title: High mobility group box 1 and kidney diseases (Review).
abstract: High mobility group box 1 (HMGB1), a non-histone DNA-binding protein, regulates nucleosome function and transcription in the nuclei of all metazoans and plants. However, extracellular HMGB1, which is actively or passively released under different conditions, can act as a key inflammatory mediator through MyD88/mitogen-activated protein kinase signaling by binding to its receptors including the receptor for advanced glycation end products or Toll-like receptors. A growing body of evidence indicates that HMGB1 plays an important role in kidney diseases, such as glomerulonephritis, lupus nephritis, antineutrophilic cytoplasmatic antibody-associated vaculitis, diabetic nephropathy, renal allograft rejection and acute kidney injury. In this review, we focus on the biology of HMGB1 and the association of HMGB1 with kidney diseases.
authors: Department of Nephrology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, PR China. topgan2000@163.com
authors: Ping
authors: P
authors: Zhu
authors: Li
authors: L
authors: Xie
authors: Hua-Sheng
authors: HS
authors: Ding
authors: Quan
authors: Q
authors: Gong
authors: Jian
authors: J
authors: Yang
authors: Lin
authors: L
authors: Yang
mesh_terms: D000818:Animals; D024243:HMGB1 Protein; D006801:Humans; D007674:Kidney Diseases; D051379:Mice; D051381:Rats
chemical_list: D024243:HMGB1 Protein