title: Chiral discrimination and interaction mechanism between enantiomers and serum albumins.
abstract: The chiral discrimination studies of biological system are theoretically and practically significant for the development of chiral drugs and life science. Our work has embarked upon the interaction between serum albumin (SA) (including human SA and bovine SA), R,S-1-(4-methoxyphenyl)ethylamine, and R,S-1-(3-methoxyphenyl)ethylamine. The formation of intermediate transition state, binding sites, and chiral discrimination ability can be investigated by ultraviolet-visible spectra and fluorescence spectra. Moreover, both the changes of hydrophobic microenvironment and energy transfer can be detected by synchronous fluorescence spectra and fluorescence lifetime.
authors: School of Chemistry and Environment, South China Normal University, Guangzhou, 510006, China.
authors: ZhiLi
authors: Z
authors: Fang
authors: WenCui
authors: W
authors: Su
authors: WeiGuang
authors: W
authors: Zhang
authors: Yan
authors: Y
authors: Xu
authors: YaJin
authors: Y
authors: Xiong
authors: MiaoLi
authors: M
authors: Luo
authors: Jun
authors: J
authors: Fan
authors: Xia
authors: X
authors: Yin
mesh_terms: D000818:Animals; D001665:Binding Sites; D002417:Cattle; D004735:Energy Transfer; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D014439:Tyramine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D012710:Serum Albumin, Bovine; C008510:O-methyltyramine; D014439:Tyramine