title: The -308 G>A SNP of TNFA is a factor predisposing to chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarian individuals: conclusions of a genetic study with multiple stratifications.
abstract: Single nucleotide polymorphisms (SNPs) of the tumour necrosis factor alpha (TNFα) gene (TNFA) have been extensively studied and shown to be associated with an increased risk of the development of various chronic inflammatory diseases. Inflammation has been demonstrated to play a central role in the pathogenesis of chronic rhinosinusitis (CRS), and TNFα is a key pro-inflammatory cytokine with important functions in these processes. In order to determine whether the well-known TNFA -308 G>A SNP has a role in a genetic predisposition to CRS in the Hungarian population, we analyzed our genomic collection containing control and CRS patient samples in a case-control study, and compared the genotype and allele frequencies. There was no significant difference in the observed genotype or allele frequencies between the controls and the total CRS group. However, after careful stratification of the patient group on the basis of the observed clinical symptoms, we found a significantly higher carriage rate of the rare A allele-containing genotypes among the CRS patients with nasal polyposis (NP) who also exhibited sensitivity to aspirin (acetylsalicylic acid, ASA(+)). It is concluded that genetic variants of the TNFA gene may affect the risk of CRS in a clinically well-defined group of CRSNP(+)ASA(+) patients in the Hungarian population. Our results also emphasize that the group of CRS patients is not homogenous in that patients exhibiting different clinical symptoms exist. Their carried genetic predisposing factors, and as a result, the exact molecular events leading to the development of various forms of CRS, may also differ.
authors: MTA-SZTE Dematological Research Group, Szeged, Hungary.
authors: Kornélia
authors: K
authors: Szabó
authors: Ágnes
authors: Á
authors: Kiricsi
authors: Mónika
authors: M
authors: Révész
authors: Ida
authors: I
authors: Vóna
authors: Zsolt
authors: Z
authors: Szabó
authors: Zsolt
authors: Z
authors: Bella
authors: Hilda
authors: H
authors: Polyánka
authors: Edit
authors: E
authors: Kadocsa
authors: Lajos
authors: L
authors: Kemény
authors: Márta
authors: M
authors: Széll
authors: Andor
authors: A
authors: Hirschberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D055963:Asthma, Aspirin-Induced / Q000235:genetics* / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006814:Hungary; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics* / Q000276:immunology; D012220:Rhinitis / Q000235:genetics* / Q000276:immunology; D012852:Sinusitis / Q000235:genetics* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: TNFA –308 G>A; chronic rhinosinusitis; nasal polyposis; single nucleotide polymorphism