title: An asymmetric synthesis of trans-fused butyrolactones from endoperoxides.
abstract: The intermolecular addition of 1,3-dicarbonyl equivalents to endoperoxides in the presence of an organocatalyst yields trans-fused butyrolactones in high yield and enantioselectivities. This methodology expands the synthetic utility of endoperoxides and further underlines their potential as sources of oxygen functionality for natural and non-natural product target synthesis.
authors: Department of Chemistry, Loughborough University, Leicestershire LE11 3TU, UK.
authors: Joshua
authors: J
authors: Priest
authors: Mark R
authors: MR
authors: Longland
authors: Mark R J
authors: MR
authors: Elsegood
authors: Marc C
authors: MC
authors: Kimber
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D010545:Peroxides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010545:Peroxides; D015107:4-Butyrolactone