title: [Protective effect of licoflavone on gastric mucosa in rats with chronic superficial gastritis].
abstract: OBJECTIVE
  To evaluate the protective effect of licoflavone on gastric mucosa in rats with chronic superficial gastritis and explore the possible mechanism.
  
  
  METHODS
  SD rat models of chronic superficial gastritis was established by intragastric administration of 0.02% ammonia and long-term irregular diet. The rat models were then randomized into model group, vitacoenzyme group and 3 licoflavone groups of high, medium, and low doses. After 30 days of treatment, the gastric histopathology, mucosal lesions, scanning electron microscopy, mucin function production by the gastric mucosa epithelial cells, serum PGE(2) level and gastric microcirculation were assessed to evaluate the protective effect of licoflavone on gastric mucosa.
  
  
  RESULTS
  Compared with normal control rats, the rat models of chronic superficial gastritis showed significantly higher gastric mucosal injury rate, histopathological scores and gastric mucin content. Licoflavone significantly ameliorated gastric pathology and increased serum PGE(2) level, enhanced acidic mucin secretion by the epithelial cells, and improved gastric microcirculation in the rat models.
  
  
  CONCLUSIONS
  Licoflavone feeding suppresses gastric mucosa injury, protects and restores the injured mucosa in rats with chronic superficial gastritis, and these effects are related with the up-regulation of serum PGE(2) level.
authors: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China. xiaochunll@163.com
authors: Xiao-Chun
authors: XC
authors: Lin
authors: Yu-Yao
authors: YY
authors: Chen
authors: Shu-Tong
authors: ST
authors: Bai
authors: Jun
authors: J
authors: Zheng
authors: Li
authors: L
authors: Tong
mesh_terms: D000818:Animals; D002908:Chronic Disease; D015232:Dinoprostone / Q000097:blood; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D047309:Flavones / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005756:Gastritis / Q000473:pathology*; D008297:Male; D008833:Microcirculation; D009077:Mucins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D047309:Flavones; D009077:Mucins; D015232:Dinoprostone