title: Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA.
abstract: OBJECTIVE
  Alterations in CXCL10 (a Th1 chemokine) expression have been associated with various diseases. The aim of this study was to evaluate the serum CXCL10 levels in H. pylori-infected patients with peptic ulcer (PU), H. pylori-infected asymptomatic (AS) subjects and healthy H. pylori-negative subjects, and also to determine its association with bacterial virulence factor cytotoxin-associated gene A (CagA).
  
  
  METHODS
  Serum samples from 90 H. pylori infected patients with PU (70 were anti-CagA(+), 20 were anti-CagA(-)), 65 AS carriers (40 were anti-CagA(+), 25 were anti-CagA(-)) and 30 healthy H. pylori-negative subjects (as a control group) were tested for concentrations of CXCL10 by using the ELISA method.
  
  
  RESULTS
  The mean serum levels of CXCL10 in PU patients (96.64 ± 20.85 pg/mL) were significantly lower than those observed in AS subjects (162.16 ± 53.31 pg/mL, P < 0.01) and the control group (193.93 ± 42.14 pg/mL, P < 0.02). In the PU group, the serum levels of CXCL10 in anti-CagA(+) subjects was significantly higher in comparison to anti-CagA(-) patients (P < 0.04).
  
  
  CONCLUSIONS
  These results showed that the mean concentrations of CXCL10 in H. pylori-infected-PU patients was lower than AS carriers and control group. In the PU group, the serum levels of CXCL10 were associated with bacterial factor CagA.
authors: Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran ; Immunology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran ; Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors: Abdollah
authors: A
authors: Jafarzadeh
authors: Maryam
authors: M
authors: Nemati
authors: Mohammad Taghi
authors: MT
authors: Rezayati
authors: Hossain
authors: H
authors: Khoramdel
authors: Mansooreh
authors: M
authors: Nabizadeh
authors: Gholamhossain
authors: G
authors: Hassanshahi
authors: Hamid
authors: H
authors: Abdollahi
keywords: Anti-CagA; Chemokine CXCL10; Helicobacter pylori; Iran; Kerman Province; Peptic Ulcer; Rafsanjan