title: [Toward therapeutic application of IL-10-producing regulatory T cells].
abstract: IL-10 is an anti-inflammatory cytokine with an important role in preventing inflammatory and autoimmune responses. IL-10 is also important for suppressive function of inducible regulatory T (iTreg) cells, several types of which were reported in succession. Type1 regulatory T (Tr1) cell is a representative of IL-10-prroducing regulatory T cells. Although specific surface markers or origin of Tr1 cells have not fully been clarified yet, IL-27 was recently reported to induce IL-10 production in T cells and be an inducer of Tr1 cells. We previously reported that CD4(+)CD25(-)lymphocyte activation gene (LAG-3)(+) Treg (LAG3(+) Treg) is one of the peripherally inducible Tregs and functions as an immune-regulator through IL-10 production. We found that the expression level of Egr-2, a transcription factor required for T cell anergy induction, is elevated in LAG3(+) Treg and that forced expression of Egr-2 induces LAG-3 expression and IL-10 production. Egr-2 has been suggested to be a key player of regulatory function in LAG3(+) Treg. In this study, we review Tr1 cells and the mechanism of IL-10 induction by IL-27 in T cells. Also, we introduce LAG3(+) Treg and discuss the therapeutic potential of these regulatory T cells.
authors: Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo.
authors: Yukiko
authors: Y
authors: Iwasaki
authors: Keishi
authors: K
authors: Fujio
authors: Tomohisa
authors: T
authors: Okamura
authors: Atsushi
authors: A
authors: Yanai
authors: Kazuhiko
authors: K
authors: Yamamoto
mesh_terms: D000818:Animals; D015703:Antigens, CD; D001327:Autoimmune Diseases / Q000628:therapy; D051767:Early Growth Response Protein 2 / Q000502:physiology; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis*; D064094:Interleukin-27 / Q000502:physiology; D058990:Molecular Targeted Therapy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D014157:Transcription Factors / Q000502:physiology; D000093322:Lymphocyte Activation Gene 3 Protein
chemical_list: D015703:Antigens, CD; C497326:EGR2 protein, human; D051767:Early Growth Response Protein 2; D064094:Interleukin-27; D014157:Transcription Factors; D016753:Interleukin-10; D000093322:Lymphocyte Activation Gene 3 Protein; C000720326:Lag3 protein, human