title: NDM-8 metallo-β-lactamase in a multidrug-resistant Escherichia coli strain isolated in Nepal.
abstract: A novel metallo-β-lactamase, NDM-8, was identified in a multidrug-resistant Escherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal. The amino acid sequence of NDM-8 has substitutions at positions 130 (Asp to Gly) and 154 (Met to Leu) compared with NDM-1. NDM-8 showed enzymatic activities against β-lactams similar to those of NDM-1.
authors: Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan.
authors: Tatsuya
authors: T
authors: Tada
authors: Tohru
authors: T
authors: Miyoshi-Akiyama
authors: Rajan K
authors: RK
authors: Dahal
authors: Manoj K
authors: MK
authors: Sah
authors: Hiroshi
authors: H
authors: Ohara
authors: Teruo
authors: T
authors: Kirikae
authors: Bharat M
authors: BM
authors: Pokhrel
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D001483:Base Sequence; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects* / Q000235:genetics; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009390:Nepal; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism; D047090:beta-Lactams / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S; D047090:beta-Lactams; D001618:beta-Lactamases