title: In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles.
abstract: Ultrasmall gadolinium based particles have been functionalized with positively charged pyridinium quaternary ammonium and labelled with (111)In. Evidence of their active targeting properties towards proteoglycans has been demonstrated in vivo after intravenous injection into rats opening thus a route to cancer imaging and therapy.
authors: Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS - Université Claude Bernard Lyon 1, Université de Lyon, 69622 Villeurbanne Cedex, France.
authors: Jessica
authors: J
authors: Morlieras
authors: Jean-Michel
authors: JM
authors: Chezal
authors: Elizabeth
authors: E
authors: Miot-Noirault
authors: Aurélien
authors: A
authors: Vidal
authors: Sophie
authors: S
authors: Besse
authors: David
authors: D
authors: Kryza
authors: Charles
authors: C
authors: Truillet
authors: Anna
authors: A
authors: Mignot
authors: Rodolphe
authors: R
authors: Antoine
authors: Philippe
authors: P
authors: Dugourd
authors: Françoise
authors: F
authors: Redini
authors: Lucie
authors: L
authors: Sancey
authors: François
authors: F
authors: Lux
authors: Pascal
authors: P
authors: Perriat
authors: Marc
authors: M
authors: Janier
authors: Olivier
authors: O
authors: Tillement
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry* / Q000627:therapeutic use; D005682:Gadolinium / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D007205:Indium Radioisotopes / Q000737:chemistry; D007553:Isotope Labeling; D007719:Knee Joint / Q000000981:diagnostic imaging; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D011509:Proteoglycans / Q000737:chemistry / Q000378:metabolism; D011726:Pyridinium Compounds / Q000737:chemistry*; D045663:Quantum Dots; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D011877:Radionuclide Imaging; D051381:Rats
chemical_list: D003287:Contrast Media; D006573:Heterocyclic Compounds, 1-Ring; D007205:Indium Radioisotopes; D011509:Proteoglycans; D011726:Pyridinium Compounds; D000644:Quaternary Ammonium Compounds; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D005682:Gadolinium