title: A randomized controlled trial of an online intervention to improve gluten-free diet adherence in celiac disease.
abstract: OBJECTIVE
  To test the effectiveness of an interactive online intervention to improve gluten free diet adherence in adults with celiac disease.
  
  
  METHODS
  A Randomized controlled trial was conducted. A total of 189 adults with biopsy-confirmed celiac disease were recruited and randomized to receive the intervention (n=101) or to a waitlist control condition (n=88). Post-intervention data was available for 70 intervention and 64 waitlist participants. Three month follow-up data was obtained for 46/50 completers from the intervention group. The primary outcome measure was gluten-free diet adherence. Secondary outcomes were gluten-free diet knowledge, quality of life and psychological symptoms.
  
  
  RESULTS
  Results were based on intention-to-treat analyses. The intervention group evidenced significantly improved gluten-free diet adherence, and gluten-free diet knowledge following the treatment period relative to the waitlist control group. The change in knowledge did not contribute to the change in adherence. These improvements were maintained at 3-month' follow-up.
  
  
  CONCLUSIONS
  The online program was effective in improving adherence and represents a promising resource for individuals with celiac disease who are struggling to achieve or maintain adequate gluten free diet adherence.
authors: Clinical Psychology Unit, The University of Sydney, Sydney, New South Wales, Australia.
authors: Kirby
authors: K
authors: Sainsbury
authors: Barbara
authors: B
authors: Mullan
authors: Louise
authors: L
authors: Sharpe
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis / Q000178:diet therapy* / Q000523:psychology*; D003194:Computer-Assisted Instruction; D055050:Diet, Gluten-Free; D005260:Female; D005500:Follow-Up Studies; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D020407:Internet; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014850:Waiting Lists