title: Potential of targeting TGF-β for organ transplant patients.
abstract: TGF-β was originally considered as an immunoregulatory cytokine, but accumulating data demonstrate that it also plays a critical role in development of effector immunity. Since TGF- β has a potent ability to alter immune responses, modulation of the TGF-β pathway for treatment of transplantation patients could be effective if carried out in a target selective manner. This review will focus on the role of TGF-β in T cell differentiation and discuss the prospect of TGF-β as the therapeutic target of lung transplantation acceptance.
authors: Department of Microbiology & Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA. miwashima@lumc.edu
authors: Makio
authors: M
authors: Iwashima
authors: Robert
authors: R
authors: Love
mesh_terms: D000818:Animals; D017209:Apoptosis; D018106:CD28 Antigens / Q000276:immunology; D002454:Cell Differentiation; D002470:Cell Survival; D006801:Humans; D008168:Lung / Q000276:immunology; D016040:Lung Transplantation / Q000276:immunology*; D018121:Receptors, Cytokine / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000276:immunology*; D016159:Tumor Suppressor Protein p53 / Q000276:immunology
chemical_list: D018106:CD28 Antigens; D018121:Receptors, Cytokine; D016212:Transforming Growth Factor beta; D016159:Tumor Suppressor Protein p53