title: Serum amyloid A stimulates macrophage foam cell formation via lectin-like oxidized low-density lipoprotein receptor 1 upregulation.
abstract: Elevated levels of serum amyloid A (SAA) is a risk factor for cardiovascular diseases, however, the role of SAA in the pathophysiology of atherosclerosis remains unclear. Here we show that SAA induced macrophage foam cell formation. SAA-stimulated foam cell formation was mediated by c-jun N-terminal kinase (JNK) signaling. Moreover, both SAA and SAA-conjugated high density lipoprotein stimulated the expression of the important scavenger receptor lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) via nuclear factor-κB (NF-κB). A LOX1 antagonist carrageenan significantly blocked SAA-induced foam cell formation, indicating that SAA promotes foam cell formation via LOX1 expression. Our findings therefore suggest that SAA stimulates foam cell formation via LOX1 induction, and thus likely contributes to atherogenesis.
authors: Department of Biological Science, Sungkyunkwan University, Suwon 440-746, South Korea. hayoung@skku.edu
authors: Ha Young
authors: HY
authors: Lee
authors: Sang Doo
authors: SD
authors: Kim
authors: Suk-Hwan
authors: SH
authors: Baek
authors: Joon Hyuk
authors: JH
authors: Choi
authors: Kyung-Hyun
authors: KH
authors: Cho
authors: Brian A
authors: BA
authors: Zabel
authors: Yoe-Sik
authors: YS
authors: Bae
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology; D002351:Carrageenan / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D005487:Foam Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism / Q000494:pharmacology; D020935:MAP Kinase Signaling System; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D051127:Scavenger Receptors, Class E / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000685:Serum Amyloid A Protein / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D008075:Lipoproteins, HDL; D016328:NF-kappa B; C495138:Olr1 protein, mouse; D011994:Recombinant Proteins; D051127:Scavenger Receptors, Class E; D000685:Serum Amyloid A Protein; D002351:Carrageenan