title: Thermoresponsive bacterial cellulose whisker/poly(NIPAM-co-BMA) nanogel complexes: synthesis, characterization, and biological evaluation.
abstract: Dispersions of poly(N-isopropylacrylamide-co-butyl methacrylate) (PNB) nanogels are known to exhibit reversible thermosensitive sol-gel phase behavior and can consequently be used in a wide range of biomedical applications. However, some dissatisfactory mechanical properties of PNB nanogels can limit their applications. In this paper, bacterial cellulose (BC) whiskers were first prepared by sulfuric acid hydrolysis and then nanosized by high-pressure homogenization for subsequent use in the preparation of BC whisker/PNB nanogel complexes (designated as BC/PNB). The mechanical properties of PNB was successfully enhanced, resulting in good biosafety. The BC/PNB nanogel dispersions exhibited phase transitions from swollen gel to shrunken gel with increasing temperature. In addition, differential scanning calorimetry (DSC) data showed that the thermosensitivity of PNB nanogels was retained. Rheological tests also indicated that BC/PNB nanogel complexes had stronger gel strengths when compared with PNB nanogels. The concentrated dispersions showed shear thinning behavior and improved toughness, both of which can play a key role in the medical applications of nanogel complexes. Furthermore, the BC/PNB nanogel complexes were noncytotoxic according to cytotoxicity and hemolysis tests. Concentrated BC/PNB nanogel dispersion displayed gel a forming capacity in situ by catheter injection, which indicates potential for a wide range of medical applications.
authors: National Engineering Research Center for Nano-Medicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors: Lei
authors: L
authors: Wu
authors: Hui
authors: H
authors: Zhou
authors: Hao-Jan
authors: HJ
authors: Sun
authors: Yanbing
authors: Y
authors: Zhao
authors: Xiangliang
authors: X
authors: Yang
authors: Stephen Z D
authors: SZ
authors: Cheng
authors: Guang
authors: G
authors: Yang
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000378:metabolism; D002482:Cellulose / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D000080385:Nanogels; D053758:Nanoparticles / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry*; D011094:Polyethyleneimine / Q000138:chemical synthesis* / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D000080385:Nanogels; D011109:Polymethacrylic Acids; C413692:polyethylene glycol polyethyleneimine nanogel; C084450:poly(N-isopropylacrylamide-co-butyl methacrylate); D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D002482:Cellulose