title: A randomized controlled trial of 1% aqueous chlorhexidine gluconate compared with 10% povidone-iodine for topical antiseptic in neonates: effects on blood culture contamination rates.
abstract: We conducted a randomized controlled trial in neonates with birth weight greater than or equal to 1,500 g that compared 1% aqueous chlorhexidine gluconate (CHG) with 10% povidone-iodine (PI) as a topical antiseptic. We found 1% CHG to be more effective than 1% PI in reducing blood culture contamination rates, and no contact dermatitis was observed.
authors: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. pracha.nun@mahidol.ac.th
authors: Pracha
authors: P
authors: Nuntnarumit
authors: Nartsiri
authors: N
authors: Sangsuksawang
mesh_terms: D000279:Administration, Cutaneous; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000009:adverse effects; D000985:Antisepsis / Q000379:methods*; D001769:Blood / Q000382:microbiology*; D001800:Blood Specimen Collection / Q000379:methods*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007231:Infant, Newborn; D017063:Outcome Assessment, Health Care; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000009:adverse effects; D012867:Skin / Q000187:drug effects / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000302:isolation & purification
chemical_list: D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine