title: Taking risk prediction to the next level. Advances in biomarker research for atherosclerosis.
abstract: Advances in risk prediction are necessary to stem the tide of the increasing incidence of global cardiovascular disease. Newly discovered biomarkers are needed for primary and secondary prevention and will undoubtedly play a major role in drug development programs and monitoring of treatment efficacy. The combination of improved -omics technologies and the investigation of relatively untapped sources of biomarkers will likely result in risk algorithms that will add value on top of the traditional risk factors. New sources of biomarkers are being explored with encouraging results. These include microvesicles, microRNAs, circulating cells and atherosclerotic plaques. We will review these sources for their potential for new biomarkers. Furthermore, the major impact of advances in genetics on risk prediction and biomarker development programs will be discussed.
authors: Laboratory of Experimental Cardiology, University Medical Center Utrecht, Address: Heidelberglaan 100 Room G02.5.23, 3584CX Utrecht, the Netherlands. G.Pasterkamp@umcutrecht.nl.
authors: Marten
authors: M
authors: Siemelink
authors: Sander
authors: S
authors: van der Laan
authors: Leo
authors: L
authors: Timmers
authors: Imo
authors: I
authors: Hoefer
authors: Gerard
authors: G
authors: Pasterkamp
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D015415:Biomarkers / Q000032:analysis*; D035843:Biomedical Research; D055808:Drug Discovery; D006801:Humans; D011322:Primary Prevention; D012307:Risk Factors; D055502:Secondary Prevention
chemical_list: D015415:Biomarkers