title: Severe thrombocytopenia in a child secondary to passive platelet antibody transfer from a plasma transfusion.
abstract: Although rare, passive transfer of platelet antibodies through blood products can result in thrombocytopenia, acute transfusion reactions, and death. We report a case of severe alloimmune thrombocytopenia from a plasma transfusion. A postliver transplant patient with a normal platelet count received fresh frozen plasma before liver biopsy. Postbiopsy, she developed cardiorespiratory distress, petechiae, and severe thrombocytopenia (platelet count 2000/μL). Her platelet count recovered to normal after 1 week. This diagnosis should be considered whenever an unexpected drop in the platelet count occurs after a plasma-rich transfusion. Conservative transfusion practices and more targeted donor screening may prevent similar events.
authors: Department of Pediatrics, Division of Hematology-Oncology-BMT, Medical College of Wisconsin, Milwaukee, WI 53226, USA. clcollin@mcw.edu
authors: Chelsea L
authors: CL
authors: Collins
authors: J Paul
authors: JP
authors: Scott
authors: Julie A
authors: JA
authors: Panepinto
authors: Rowena C
authors: RC
authors: Punzalan
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology; D016913:Blood Component Transfusion / Q000009:adverse effects*; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000009:adverse effects / Q000276:immunology*; D016031:Liver Transplantation; D010949:Plasma / Q000276:immunology*; D013921:Thrombocytopenia / Q000276:immunology*
chemical_list: D016824:Antigens, Human Platelet; D007518:Isoantibodies