title: [Immunologic and genetic markers of exposure to aromatic hydrocarbons in workers].
abstract: Workers exposed to aromatic hydrocarbons appeared to have prevalence of heterozygous variants of CYP1A1 gene (9893 A/G) and tumor necrosis factor gene reliably higher vs. the reference group 2.5 and 3.3 times respectively, and level of anti-benzene antibodies (IgG) increased vs. the reference group. The data presented demonstrate negative immunogenetic associations of aromatic hydrocarbons influence on oil extraction operators.
authors: O V
authors: OV
authors: Dolgikh
authors: A V
authors: AV
authors: Krivtsov
authors: A M
authors: AM
authors: Gugovich
authors: R A
authors: RA
authors: Kharakhorina
authors: D V
authors: DV
authors: Lanin
authors: T S
authors: TS
authors: Lykhina
authors: M A
authors: MA
authors: Safonova
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001711:Biotransformation / Q000187:drug effects; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D019652:Extraction and Processing Industry; D005260:Female; D005819:Genetic Markers; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000097:blood / Q000633:toxicity; D007108:Immune Tolerance / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D015166:Monitoring, Immunologic / Q000379:methods; D016273:Occupational Exposure / Q000009:adverse effects*; D011110:Polymorphism, Genetic / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D006841:Hydrocarbons, Aromatic; D014409:Tumor Necrosis Factor-alpha; D007073:Immunoglobulin E; D019363:Cytochrome P-450 CYP1A1