title: Isolated fever induced by mesalamine treatment.
abstract: Adverse reactions to mesalamine, a treatment used to induce and maintain remission in inflammatory bowel diseases, particularly ulcerative colitis, have been described in the literature as case reports. This case illustrates an unusual adverse reaction. Our patient developed an isolated fever of unexplained etiology, which was found to be related to mesalamine treatment. A 22-year-old patient diagnosed with ulcerative colitis developed a fever with rigors and anorexia 10 d after starting oral mesalamine while his colitis was clinically resolving. Testing revealed no infection. A mesalamine-induced fever was considered, and treatment was stopped, which led to spontaneous resolution of the fever. The diagnosis was confirmed by reintroducing the mesalamine. One year later, this side effect was noticed again in the same patient after he was administered topical mesalamine. This reaction to mesalamine seems to be idiosyncratic, and the mechanism that induces fever remains unclear. Fever encountered in the course of a mesalamine treatment in ulcerative colitis must be considered a mesalamine-induced fever when it cannot be explained by the disease activity, an associated extraintestinal manifestation, or an infectious etiology.
authors: Department of Gastroenterology, Hotel Dieu de France University Hospital, Saint Joseph University, Beirut 94010, Lebanon. rslimkaram@hotmail.com
authors: Rita
authors: R
authors: Slim
authors: Joseph
authors: J
authors: Amara
authors: Roy
authors: R
authors: Nasnas
authors: Khalil
authors: K
authors: Honein
authors: Joseph Bou
authors: JB
authors: Jaoude
authors: Cesar
authors: C
authors: Yaghi
authors: Fady
authors: F
authors: Daniel
authors: Raymond
authors: R
authors: Sayegh
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy*; D005334:Fever / Q000139:chemically induced* / Q000175:diagnosis; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005765:Gastrointestinal Agents; D019804:Mesalamine
keywords: 5-aminosalicylic acid; Adverse reactions; Fever; Mesalamine; Side effects