title: Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/Michael addition via dynamic kinetic resolution: access to highly functionalized chromans with three contiguous stereocenters.
abstract: An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chromans with three contiguous stereocenters, including one quaternary center. In addition, a novel cascade sulfa Michael/retro-sulfa-Michael/sulfa-Michael/Michael reaction process, involving dynamic kinetic resolution, is described.
authors: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
authors: Wen
authors: W
authors: Yang
authors: Yi
authors: Y
authors: Yang
authors: Da-Ming
authors: DM
authors: Du
mesh_terms: D000577:Amides / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry; D003503:Cyclobutanes / Q000737:chemistry; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D002839:Chromans; D003503:Cyclobutanes; D013457:Sulfur Compounds; C030042:squaric acid