title: Natural compounds with cell growth inhibitory activity in human tumor cell lines.
abstract: Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2'-hydroxy-3,4,4',5,6'-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.
authors: Cristiane M
authors: CM
authors: Cazal
authors: Kantima
authors: K
authors: Choosang
authors: Vanessa Gisele P
authors: VG
authors: Severino
authors: João B
authors: JB
authors: Fernandes
authors: Maria Fátima G F
authors: MF
authors: da Silva
authors: Paulo C
authors: PC
authors: Vieira
authors: Maria S J
authors: MS
authors: Nascimento
authors: Gabriela M
authors: GM
authors: Almeida
authors: M Helena
authors: MH
authors: Vasconcelos
authors: Pannee
authors: P
authors: Pakkong
authors: CEQUIMED-UP/CEQOFFUP - Centro de Estudos de Quimica, Medicinal, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal, Departamento de Ciencias Quimicas, Laboratorio de Quimica Organica e Farmaceutica, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal. madalena@ff.up.pt.
authors: Madalena M M
authors: MM
authors: Pinto
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: C450644:2'-hydroxy-3,4,3',4',6'-pentamethoxychalcone; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones; D003374:Coumarins; D005419:Flavonoids; C041477:3-hydroxyflavone