title: Palladium-catalyzed carbonylative Sonogashira coupling of aryl bromides via tert-butyl isocyanide insertion.
abstract: A simple and efficient palladium-catalyzed carbonylative Sonogashira coupling via tert-butyl isocyanide insertion has been developed, which demonstrates the utility of isocyanides in intermolecular C-C bond construction. This methodology provides a novel pathway for the synthesis of alkynyl imines which can undergo simple silica gel catalyzed hydrolysis to afford alkynones. The approach is tolerant of a wide range of substrates and applicable to library synthesis.
authors: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, People's Republic of China.
authors: Ting
authors: T
authors: Tang
authors: Xiang-Dong
authors: XD
authors: Fei
authors: Zhi-Yuan
authors: ZY
authors: Ge
authors: Zhong
authors: Z
authors: Chen
authors: Yong-Ming
authors: YM
authors: Zhu
authors: Shun-Jun
authors: SJ
authors: Ji
mesh_terms: D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D001965:Bromides; D007659:Ketones; D009570:Nitriles; D009942:Organometallic Compounds; D010165:Palladium; C099535:tert-butyl isocyanide