title: Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure.
abstract: BACKGROUND
  Uric acid may be involved in the pathogenesis of hypertension. We investigated the roles of four major hemodynamic parameters of blood pressure, including arterial stiffness, wave reflections, cardiac output (CO), and total peripheral resistance (TPR), in the association between uric acid and central systolic blood pressure (SBP-c).
  
  
  METHODS
  A sample of 1303 normotensive and untreated hypertensive Taiwanese participants (595 women, aged 30-79 years) was drawn from a community-based survey. Study subjects' baseline characteristics, biochemical parameters, carotid-femoral pulse wave velocity (cf-PWV), amplitude of the backward pressure wave decomposed from a calibrated tonometry-derived carotid pressure waveform (Pb), CO, TPR, and SBP-c were analyzed.
  
  
  RESULTS
  In multi-variate analyses adjusted for age, waist circumference, body mass index, creatinine, total cholesterol, smoking, and heart rate, uric acid significantly correlated with Pb and cf-PWV in men, and Pb and TPR in women. The correlation between uric acid and Pb remained significant in men and women when cf-PWV was further adjusted. In the final multi-variate prediction model (model r(2)=0.839) for SBP-c, the significant independent variables included uric acid (partial r(2)=0.005), Pb (partial r(2)=0.651), cf-PWV (partial r(2)=0.005), CO (partial r(2)=0.062), TPR (partial r(2)=0.021), with adjustment for age, sex, waist circumference, body mass index, creatinine, total cholesterol, smoking, and heart rate.
  
  
  CONCLUSIONS
  Uric acid was significantly independently associated with wave reflections, which is the dominant determinant of SBP-c. Uric acid was also significantly associated with SBP-c independently of the major hemodynamic parameters.
authors: Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Public Health, National Yang-Ming University, Taipei, Taiwan; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan.
authors: Pai-Feng
authors: PF
authors: Hsu
authors: Shao-Yuan
authors: SY
authors: Chuang
authors: Hao-Min
authors: HM
authors: Cheng
authors: Shih-Hsien
authors: SH
authors: Sung
authors: Chih-Tai
authors: CT
authors: Ting
authors: Edward G
authors: EG
authors: Lakatta
authors: Frank C P
authors: FC
authors: Yin
authors: Pesus
authors: P
authors: Chou
authors: Chen-Huan
authors: CH
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D015992:Body Mass Index; D002339:Carotid Arteries / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow / Q000502:physiology; D063177:Pulse Wave Analysis; D013318:Stroke Volume; D013599:Systole; D014527:Uric Acid / Q000097:blood*; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D014527:Uric Acid
keywords: Arterial stiffness; Hypertension; Uric acid; Wave reflection; c-Peptide