title: Organocatalytic domino reaction of cyanosulfones: access to complex cyclohexane systems with quaternary carbon centers.
abstract: When ε-nitro-α,β-unsaturated esters are added to conjugated cyanosulfones in the presence of a bifunctional thiourea catalyst, a highly stereoselective domino reaction occurs to generate complex cyclohexanes with up to four stereogenic centers, one of which is quaternary in nature. Therefore, it is demonstrated that, like nitro compounds, sulfones can undergo an asymmetric intramolecular conjugate addition to α,β-unsaturated esters in the presence of a bifunctional organocatalyst.
authors: School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading, Berks RG6 6AD, UK.
authors: Sundaram
authors: S
authors: Rajkumar
authors: Kenneth
authors: K
authors: Shankland
authors: Jonathan M
authors: JM
authors: Goodman
authors: Alexander J A
authors: AJ
authors: Cobb