title: [Skin, sun exposure and vitamin D: facts and controversies].
abstract: Vitamin D plays a clearly defined role in phosphorus, calcium and bone metabolism. In addition to its effects on cellular proliferation and differentiation, and on immunity, it appears to exert other action, poorly understood to date, on human physiology and disease. A number of epidemiological studies have demonstrated a protective role of sun exposure with regard to the incidence of certain immune diseases and cancer, and upon the related mortality rates. Furthermore, over the last 10 years, studies have purported to find levels judged "inadequate" in numerous populations, and, in the absence of any strict scientific arguments, a correlation was established by certain authors between supposedly "inadequate" levels, sun exposure and risk of cancer. However, analysis of the literature shows that there is in fact no precise and consensual definition of normal ranges and that the notion of inadequacy was created artificially using assay techniques lacking in sensitivity and reproducibility. Photosynthesis of vitamin D can in fact be considered perfectly adequate in the majority of populations. However, greater care is needed with elderly subjects and with subjects exposed very little to sunlight. Current studies show that the means of photoprotection used in everyday life do not adversely affect such photosynthesis. In the event of documented vitamin D deficiency, oral supplements should be given, and exposure to natural or artificial UV radiation should not be prescribed. Ultraviolet radiation has been shown to be carcinogenic and responsible for the onset of most skin cancers, and the population must be warned against misleading advertising from the tanning industry. Care should also be taken with regard to the potential harmful effects of inappropriate vitamin D supplementation.
authors: Clinique de dermatologie et photobiologie, pôle pluridisciplinaire de médecine, CHU A.-Michallon, 38043 Grenoble cedex, France. MTLeccia@chu-grenoble.fr
authors: M-T
authors: MT
authors: Leccia
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002319:Cardiovascular System; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007107:Immune System / Q000502:physiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000517:prevention & control; D010758:Phosphorus / Q000378:metabolism; D011481:Protective Clothing / Q000009:adverse effects; D012867:Skin / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control; D055108:Sunbathing; D013472:Sunlight / Q000009:adverse effects; D013473:Sunscreening Agents / Q000009:adverse effects / Q000627:therapeutic use; D055107:Suntan; D014466:Ultraviolet Rays / Q000009:adverse effects; D014807:Vitamin D / Q000008:administration & dosage / Q000009:adverse effects / Q000096:biosynthesis / Q000502:physiology* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control
chemical_list: D013473:Sunscreening Agents; D014807:Vitamin D; D010758:Phosphorus; D002118:Calcium