title: [Preventive administration of new UDCA derivatives in experimental alcoholic steatohepatitis].
abstract: We have studied the prophylactic effect of new derivatives of ursodeoxycholic acid (UDCA), including UDCA-N-acetylcysteine, UDCA-L-acetylcysteine, and nor-UDCA (in doses equivalent to 40 mg/kg of UDCA) on the development of experimental alcoholic steatohepatitis induced by the Lieber-DeCarli liquid ethanol-containing diet. Results demonstrated that most of the investigated compounds produced a hepatoprotective effect, improving biochemical tests and liver morphology, as manifested by decreasing steatosis intensity, activity of alkaline phosphatase and gamma-glutamyltranspeptidase, triglyceride level in blood serum and liver, and TNF alpha content. However, nor-UDCA was most effective as compared to UDCA in preventing the accumulation of triglycerides in the liver.
authors: E B
authors: EB
authors: Belonovskaia
authors: E E
authors: EE
authors: Naruta
authors: O Ia
authors: OIa
authors: Lukivskaia
authors: V Z
authors: VZ
authors: Abakumov
authors: V U
authors: VU
authors: Buko
mesh_terms: D000111:Acetylcysteine / Q000737:chemistry; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D004032:Diet; D000431:Ethanol; D005235:Fatty Liver, Alcoholic / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014580:Ursodeoxycholic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D002756:Cholagogues and Choleretics; D020011:Protective Agents; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D000431:Ethanol; D014580:Ursodeoxycholic Acid; C081331:24-norursodeoxycholic acid; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000111:Acetylcysteine