title: Metabolic syndrome and the risk for recurrent pre-eclampsia: a retrospective cohort study.
abstract: OBJECTIVE
  To compare the prevalence of recurrent pre-eclampsia between women who have and do not have metabolic syndrome when non-pregnant.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Three tertiary referral hospitals in the Netherlands.
  
  
  METHODS
  Formerly pre-eclamptic women.
  
  
  METHODS
  The presence or absence of metabolic syndrome was assessed in 480 women at least 6 months after their first pre-eclamptic pregnancy using World Health Organization criteria. We compared the prevalence of recurrent pre-eclampsia in the subsequent pregnancy, calculating odds ratios (OR), adjusted for confounders.
  
  
  METHODS
  Recurrence of pre-eclampsia in the subsequent pregnancy.
  
  
  RESULTS
  Subsequent pregnancy outcome data were available for 197 women. Forty women had metabolic syndrome after previous pregnancy (20%). The prevalence of recurrent pre-eclampsia was 18/40 (45%) in women with metabolic syndrome versus 27/157 (17%) in women without metabolic syndrome; OR 3.94 (95% confidence interval [CI] 1.86-8.33, adjusted OR 3.77 (95% CI 1.61-8.81). The risk of recurrent pre-eclampsia increased with each extra component of the metabolic syndrome from 11.8% for absent components up to 43.9% for three or more (P for trend < 0.001).
  
  
  CONCLUSIONS
  Interpregnancy metabolic syndrome predisposes to recurrent pre-eclampsia.
authors: Department of Obstetrics and Gynaecology, Deventer Hospital, Deventer, the Netherlands. e.stekkinger@dz.nl
authors: E
authors: E
authors: Stekkinger
authors: Rr
authors: R
authors: Scholten
authors: M J
authors: MJ
authors: van der Vlugt
authors: A P J
authors: AP
authors: van Dijk
authors: M C H
authors: MC
authors: Janssen
authors: M E A
authors: ME
authors: Spaanderman
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications*; D009426:Netherlands / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors