title: The osteochondral dilemma: review of current management and future trends.
abstract: The management of articular cartilage defects remains challenging and controversial. Hyaline cartilage has limited capacity for self-repair and post-injury cartilage is predominantly replaced by fibrocartilage through healing from the subchondral bone. Fibrocartilage lacks the key properties that characterize hyaline cartilage such as capacity for compression, hydrodynamic permeability and smoothness of the articular surface. Many reports relate compromised function associated with repaired cartilage and loss of function of the articular surface. Novel methods have been proposed with the key aim to regenerate hyaline cartilage for repair of osteochondral defects. Over the past decade, with many exciting developments in tissue engineering and regenerative cell-based technologies, we are now able to consider new combinatorial approaches to overcome the problems associated with osteochondral injuries and damage. In this review, the currently accepted surgical approaches are reviewed and considered; debridement, marrow stimulation, whole tissue transplantation and cellular repair. More recent products, which employ tissue engineering approaches to enhance the traditional methods of repair, are discussed. Future trends must not only focus on recreating the composition of articular cartilage, but more importantly recapitulate the nano-structure of articular cartilage to improve the functional strength and integration of repair tissue.
authors: Department of Surgery, St Vincent's Hospital, The University of Melbourne, Fitzroy, Victoria, Australia; Department of Orthopaedics, St Vincent's Hospital, Fitzroy, Victoria, Australia.
authors: Ken
authors: K
authors: Ye
authors: Claudia
authors: C
authors: Di Bella
authors: Damian E
authors: DE
authors: Myers
authors: Peter F M
authors: PF
authors: Choong
mesh_terms: D054544:Arthroplasty, Subchondral / Q000379:methods / Q000639:trends; D001182:Arthroscopy / Q000379:methods / Q000639:trends; D016025:Bone Transplantation; D002358:Cartilage, Articular / Q000293:injuries* / Q000502:physiology / Q000601:surgery; D019902:Chondrocytes / Q000637:transplantation; D003646:Debridement; D006801:Humans; D051457:Hyaline Cartilage / Q000637:transplantation; D007718:Knee Injuries / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D019637:Orthopedic Procedures / Q000379:methods* / Q000639:trends; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D014945:Wound Healing / Q000502:physiology
keywords: bioengineering; cartilage; defects; regeneration; review