title: Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication.
abstract: Evolution has led to diversification of all living organisms from a common ancestor. Consequently, all living organisms use a common method to duplicate their genetic information and thus pass on their inherited traits to their offspring. To duplicate chromosomal DNA, double-stranded DNA must first be unwound by helicase, which is loaded to replication origins and activated during the DNA replication initiation step. In this review, we discuss the common features of, and differences in, replicative helicases between prokaryotes and eukaryotes.
authors: Division of Microbial Genetics, National Institute of Genetics, Yata 1111, Mishima City, Shizuoka, 411-8540, Japan.
authors: Yan
authors: Y
authors: Li
authors: Hiroyuki
authors: H
authors: Araki
mesh_terms: D000818:Animals; D001105:Archaea / Q000201:enzymology / Q000235:genetics; D001419:Bacteria / Q000201:enzymology / Q000235:genetics; D001426:Bacterial Proteins / Q000378:metabolism; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis* / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D056890:Eukaryota / Q000201:enzymology / Q000235:genetics; D019143:Evolution, Molecular; D006801:Humans; D018741:Replication Origin
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004259:DNA-Directed DNA Polymerase; D004265:DNA Helicases