title: Trabecular and cortical microarchitecture in postmenopausal HIV-infected women.
abstract: Our objective was to assess the effects of HIV infection and antiretroviral therapy on trabecular and cortical microarchitecture in postmenopausal minority women. A subgroup of 106 (46 HIV-infected, 60 uninfected) postmenopausal Hispanic and African American women from an established cohort had areal bone mineral density (aBMD) measured by dual-energy X-ray absorptiometry and trabecular and cortical volumetric BMD (vBMD) and microarchitecture measured by high-resolution peripheral quantitative computed tomography (HRpQCT) at the radius and tibia. HIV-infected women were slightly younger (58 ± 1 vs. 61 ± 1 years, p = 0.08), and had lower body mass index (BMI; 28 ± 1 vs. 32 ± 1 kg/m(2), p < 0.01). BMI-adjusted aBMD Z scores were lower in HIV-infected women at the lumbar spine, total hip, and ultradistal radius. Serum N-telopeptide and C-telopeptide levels were also higher in HIV-infected women. Trabecular and cortical vBMD were similar at the radius, but cortical area (105.5 ± 2.4 vs. 120.6 ± 2.0 mm(2), p < 0.01) and thickness (956 ± 33 vs. 1,075 ± 28 μm, p < 0.01) at the tibia were approximately 11-12 % lower in HIV-infected women. Differences remained significant after adjusting for age, BMI, and race/ethnicity. In contrast, cortical porosity was similar in the two groups. Although HIV-infected postmenopausal women had lower aBMD at the spine, total hip, and ultradistal radius and higher levels of bone resorption markers, the only differences detected by HRpQCT were lower cortical thickness and area at the tibia.
authors: Division of Infectious Diseases, Columbia University Medical Center, 630 West 168th Street, PH8-876, New York, NY 10032, USA. Mty4@columbia.edu
authors: Michael T
authors: MT
authors: Yin
authors: Aimee
authors: A
authors: Shu
authors: Chiyuan A
authors: CA
authors: Zhang
authors: Stephanie
authors: S
authors: Boutroy
authors: Donald J
authors: DJ
authors: McMahon
authors: David C
authors: DC
authors: Ferris
authors: Ivelisse
authors: I
authors: Colon
authors: Elizabeth
authors: E
authors: Shane
mesh_terms: D015502:Absorptiometry, Photon; D015519:Bone Density; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000000981:diagnostic imaging*; D006615:Hip / Q000000981:diagnostic imaging*; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D017698:Postmenopause; D011884:Radius / Q000000981:diagnostic imaging*