title: N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.
abstract: Novel N-alkyldeoxynojirimycins (NADNJs) with two hydrophobic groups attached to a nitrogen linker on the alkyl chain were designed. A novel NADNJ containing a terminal tertiary carboxamide moiety was discovered that was a potent inhibitor against BVDV. Further optimization resulted in a structurally more stable lead compound 24 with a submicromolar EC50 against BVDV, Dengue, and Tacaribe; and low cytotoxicity.
authors: Institute for Hepatitis and Virus Research, 3805 Old Easton Road, Doylestown, PA 18902, USA. yanming.du@ihvr.org
authors: Yanming
authors: Y
authors: Du
authors: Hong
authors: H
authors: Ye
authors: Tina
authors: T
authors: Gill
authors: Lijuan
authors: L
authors: Wang
authors: Fang
authors: F
authors: Guo
authors: Andrea
authors: A
authors: Cuconati
authors: Ju-Tao
authors: JT
authors: Guo
authors: Timothy M
authors: TM
authors: Block
authors: Jinhong
authors: J
authors: Chang
authors: Xiaodong
authors: X
authors: Xu
mesh_terms: D017485:1-Deoxynojirimycin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003673:Defective Viruses / Q000187:drug effects*; D003715:Dengue / Q000188:drug therapy*; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000998:Antiviral Agents; C501633:deoxynojirimycine; D017485:1-Deoxynojirimycin; D005944:Glucosamine