title: Maternal genotype and gestational diabetes.
abstract: OBJECTIVE
  To determine whether genetic variants associated with glucose homeostasis are associated with gestational diabetes (GDM).
  
  
  METHODS
  We genotyped 899 self-identified Caucasian women and 386 self-identified African-American women in the Pregnancy, Infection and Nutrition (PIN) Studies cohorts for 38 single-nucleotide polymorphisms (SNPs) associated with type II diabetes (T2DM) and/or glucose homeostasis in European populations.
  
  
  RESULTS
  GDM was diagnosed in 56 of 899 (6.2%) Caucasian and 24 of 386 (6.2%) African-American women. Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and GCKR rs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations. Among African-American participants, we found an increased risk among TSPAN8 rs7961581 C allele homozygotes and reduced risk among carriers of the JAZF1 rs864745 T allele.
  
  
  CONCLUSIONS
  We found several SNPs that are associated with GDM risk in the PIN cohorts. Maternal genotyping may identify women at risk for impaired gestational glucose tolerance.
authors: Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
authors: Alison M
authors: AM
authors: Stuebe
authors: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors: Alison
authors: A
authors: Wise
authors: Division of Genetics and Endocrinology, Children's Hospital of Boston, Harvard Medical School, Boston, Massachusetts.
authors: Thutrang
authors: T
authors: Nguyen
authors: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors: Amy
authors: A
authors: Herring
authors: Department of Epidemiology, Gillings School of Global Public Health, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors: Kari E
authors: KE
authors: North
authors: Department of Epidemiology, Gillings School of Global Public Health, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors: Anna Maria
authors: AM
authors: Siega-Riz
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000235:genetics*; D001786:Blood Glucose / Q000235:genetics; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D016640:Diabetes, Gestational / Q000208:ethnology / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006706:Homeostasis / Q000235:genetics; D006720:Homozygote; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics; D009657:North Carolina; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D044123:Receptor, Melatonin, MT2 / Q000235:genetics; D059470:Tetraspanins / Q000235:genetics; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D001786:Blood Glucose; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; C485100:GCKR protein, human; C430460:JAZF1 protein, human; C573871:MTNR1B protein, human; D009363:Neoplasm Proteins; D044123:Receptor, Melatonin, MT2; C544894:TCF7L2 protein, human; C065609:TSPAN8 protein, human; D059470:Tetraspanins; D058118:Transcription Factor 7-Like 2 Protein