title: Compatibility of butorphanol and droperidol in 0.9% sodium chloride injection.
abstract: OBJECTIVE
  The compatibility and stability of butorphanol tartrate and droperidol in polyvinyl chloride (PVC) bags and glass bottles stored at 4°C and 25°C for up to 15 days were studied.
  
  
  METHODS
  Admixtures were assessed initially and for 15 days after preparation in PVC bags and glass bottles using 0.9% sodium chloride injection as a diluent and stored at 4°C and 25°C. The initial drug concentrations were 0.08 mg/mL for butorphanol tartrate and 0.05 mg/mL for droperidol. Samples were withdrawn from each container immediately after preparation and at predetermined intervals (2, 4, 8, 24, 48, 72, 120, 168, 240, and 360 hours after preparation). The solutions were visually inspected for precipitation, cloudiness, and discoloration at each sampling interval. Drug concentrations were determined using a validated high-pressure liquid chromatography method.
  
  
  RESULTS
  After 15 days of storage, all formulations tested retained >98% of the initial concentrations of both drugs. The drug mixtures were clear in appearance, and no color change or precipitation was observed. Throughout this period, pH values remained stable.
  
  
  CONCLUSIONS
  Admixtures of butorphanol tartrate 0.08 mg/mL and droperidol 0.05 mg/mL in 0.9% sodium chloride injection were stable for at least 360 hours when stored in PVC bags or glass bottles at 4°C and 25°C and protected from light.
authors: Department of Pharmacy, Dongfeng Hospital (DH), Hubei University of Medicine, Hubei, Republic of China.
authors: Fu-Chao
authors: FC
authors: Chen
authors: Bao-Xia
authors: BX
authors: Fang
authors: Peng
authors: P
authors: Li
authors: Jin-Guo
authors: JG
authors: Yang
authors: Ben-Hong
authors: BH
authors: Zhou
mesh_terms: D002077:Butorphanol / Q000008:administration & dosage / Q000378:metabolism / Q000592:standards*; D004329:Droperidol / Q000008:administration & dosage / Q000378:metabolism / Q000592:standards*; D004347:Drug Interactions / Q000502:physiology; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods / Q000592:standards; D007275:Injections, Intravenous; D019999:Pharmaceutical Solutions; D012965:Sodium Chloride / Q000008:administration & dosage / Q000378:metabolism / Q000592:standards*
chemical_list: D019999:Pharmaceutical Solutions; D012965:Sodium Chloride; D004329:Droperidol; D002077:Butorphanol