title: ROS regulation of microdomain Ca(2+) signalling at the dyads.
abstract: Reactive oxygen species (ROS) are emerging as centre-stage players in cardiac functional regulation. ROS and Ca(2+) signals converge at dyads, the structural and functional units of cardiac excitation-contraction coupling. These two prominent signalling systems are intertwined with ROS modulation of the entire Ca(2+)-signalling network, and vice versa. While constitutively generated homoeostatic ROS are important in setting the redox potential of the intracellular milieu, dynamic signalling ROS shape microdomain and global Ca(2+) signals on both the beat-to-beat and greater time scales. However, ROS effects are complex and subtle, characterized by multiphasic and bidirectional Ca(2+) responses; and sustained oxidative stress may lead to compromised contractility and arrhythmogenicity. These new understandings should be leveraged to harness ROS for their beneficial roles while avoiding deleterious effects in the heart.
authors: State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing 100871, China.
authors: Huiliang
authors: H
authors: Zhang
authors: Ana M
authors: AM
authors: Gomez
authors: Xianhua
authors: X
authors: Wang
authors: Yuan
authors: Y
authors: Yan
authors: Ming
authors: M
authors: Zheng
authors: Heping
authors: H
authors: Cheng
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D056966:Excitation Contraction Coupling; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000648:ultrastructure; D019255:NADPH Oxidases / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D019255:NADPH Oxidases