title: Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats.
abstract: OBJECTIVE
  To investigate the therapeutic effects and acting mechanism of a combination of Chinese herb active components, i.e., a combination of baicalin, jasminoidin and cholic acid (CBJC) on Alzheimer's disease (AD).
  
  
  METHODS
  Male rats were intracerebroventricularly injected with ibotenic acid (IBO), and CBJC was orally administered. Therapeutic effect was evaluated with the Morris water maze test, FDG-PET examination, and histological examination, and the acting mechanism was studied with DNA microarrays and western blotting.
  
  
  RESULTS
  CBJC treatment significantly attenuated IBO-induced abnormalities in cognition, brain functional images, and brain histological morphology. Additionally, the expression levels of 19 genes in the forebrain were significantly influenced by CBJC; approximately 60% of these genes were related to neuroprotection and neurogenesis, whereas others were related to anti-oxidation, protein degradation, cholesterol metabolism, stress response, angiogenesis, and apoptosis. Expression of these genes was increased, except for the gene related to apoptosis. Changes in expression for 5 of these genes were confirmed by western blotting.
  
  
  CONCLUSIONS
  CBJC can ameliorate the IBO-induced dementia in rats and may be significant in the treatment of AD. The therapeutic mechanism may be related to CBJC's modulation of a number of processes, mainly through promotion of neuroprotection and neurogenesis, with additional promotion of anti-oxidation, protein degradation, etc.
authors: School of Basic Medical Sciences, Lanzhou University, Lanzhou, P. R. China.
authors: Junying
authors: J
authors: Zhang
authors: Peng
authors: P
authors: Li
authors: Yanping
authors: Y
authors: Wang
authors: Jianxun
authors: J
authors: Liu
authors: Zhanjun
authors: Z
authors: Zhang
authors: Weidong
authors: W
authors: Cheng
authors: Yongyan
authors: Y
authors: Wang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D019826:Cholic Acid / Q000008:administration & dosage; D003704:Dementia / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005419:Flavonoids / Q000008:administration & dosage; D006801:Humans; D007051:Ibotenic Acid / Q000633:toxicity; D039823:Iridoids / Q000008:administration & dosage; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D039823:Iridoids; D018696:Neuroprotective Agents; C007835:geniposide; D007051:Ibotenic Acid; C038044:baicalin; D019826:Cholic Acid