title: Intensive glycemic control in type 2 diabetics at high cardiovascular risk: do the benefits justify the risks?
abstract: Perkovic et al. use novel data from the ADVANCE study to report on the potential renal benefits of standard glycemic control, compared with intensive glycemic control (mean hemoglobin A1c 7.3 and 6.5%, respectively). Intensive glycemic control reduced the risk of new-onset microalbuminuria, new-onset macroalbuminuria, and progression of albuminuria. The risk of end-stage renal disease was also reduced in patients treated with intensive glycemic control, although the number of events was small.
authors: Department of Medicine, University of Alberta, Edmonton, Canada.
authors: Sabin
authors: S
authors: Shurraw
authors: Marcello
authors: M
authors: Tonelli
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000517:prevention & control*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000517:prevention & control*
chemical_list: D001786:Blood Glucose