title: The transcriptomic response of mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin d3 includes genes limiting the progression of neurodegenerative diseases.
abstract: Seasonal or chronic vitamin D deficiency and/or insufficiency is highly prevalent in the human population. Receptors for 1,25-dihydroxyvitamin D3, the hormonal metabolite of vitamin D, are found throughout the brain. To provide further information on the role of this hormone on brain function, we analyzed the transcriptomic profiles of mixed neuron-glial cell cultures in response to 1,25-dihydroxyvitamin D3. 1,25-dihydroxyvitamin D3 treatment increases the mRNA levels of 27 genes by at least 1.9 fold. Among them, 17 genes were related to neurodegenerative and psychiatric diseases, or brain morphogenesis. Notably, 10 of these genes encode proteins potentially limiting the progression of Alzheimer's disease. These data provide support for a role of 1,25-dihydroxyvitamin D3 in brain disease prevention. The possible consequences of circannual or chronic vitamin D insufficiencies on a tissue with a low regenerative potential such as the brain should be considered.
authors: INSERM U836, Bâtiment Edmond J. Safra, Université Joseph Fourier, CHU Michallon, Grenoble, France.
authors: Marie-France
authors: MF
authors: Nissou
authors: Jacques
authors: J
authors: Brocard
authors: Michèle
authors: M
authors: El Atifi
authors: Audrey
authors: A
authors: Guttin
authors: Annie
authors: A
authors: Andrieux
authors: François
authors: F
authors: Berger
authors: Jean-Paul
authors: JP
authors: Issartel
authors: Didier
authors: D
authors: Wion
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002117:Calcitriol / Q000494:pharmacology*; D002460:Cell Line; D018450:Disease Progression; D053595:Embryonic Stem Cells / Q000187:drug effects / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000503:physiopathology; D051379:Mice; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000503:physiopathology*; D009457:Neuroglia / Q000187:drug effects* / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010300:Parkinson Disease / Q000235:genetics / Q000503:physiopathology; D012333:RNA, Messenger / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000187:drug effects / Q000235:genetics; D059467:Transcriptome / Q000187:drug effects*; D030181:Vitamin D Response Element / Q000187:drug effects / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D018167:Receptors, Calcitriol; D002117:Calcitriol