title: Linking membrane dynamics and trafficking to autophagy and the unfolded protein response.
abstract: Cellular stressors typically induce two protective counter-responses-autophagy and the unfolded protein response (UPR). It is conceivable that these two endoplasmic reticulum (ER) membrane-based processes would intersect/interact somehow with the constitutive housekeeping process of exocytic membrane traffic from the ER. How exactly might this occur? Recent evidence indicates that a conserved Rab protein, Rab1/Ypt1p, has functional roles in UPR and autophagy. This molecular switch and its associated effectors may therefore serve to link up a network of cellular responses to stress through changes in membrane dynamics and protein turnover. The notion provides further explanations as to why elevation of Rab1/Ypt1p levels could counter the cytotoxicity of α-synuclein, and a similar mode of protection may well be at work against other stresses.
authors: Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, NUS Graduate School of Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore.
authors: Christelle En Lin
authors: CE
authors: Chua
authors: Bor Luen
authors: BL
authors: Tang
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D056811:Unfolded Protein Response / Q000502:physiology*; D020691:rab GTP-Binding Proteins / Q000502:physiology; D020761:rab1 GTP-Binding Proteins / Q000502:physiology
chemical_list: D029701:Saccharomyces cerevisiae Proteins; C060755:YPT1 protein, S cerevisiae; D020691:rab GTP-Binding Proteins; D020761:rab1 GTP-Binding Proteins