title: Salivary innate defense system in type 1 diabetes mellitus in children with mixed and permanent dentition.
abstract: OBJECTIVE
  It should be expected that type 1 diabetes mellitus may disturb innate and acquired immunity. There are no data on type 1 diabetes mellitus-related changes in the salivary flow and the protein output responsible for the innate immunity of saliva depending on the quality of dentition reflecting the age of child. The aim of this work was the evaluation of parameters responsible for the innate immunity of saliva in children and adolescents with type 1 diabetes mellitus.
  
  
  METHODS
  In diabetic children, adolescent and healthy volunteers, the salivary flow, the output and the concentration of the activity of peroxidase (colorimetry), lysozyme (radial immunodiffusion) and lactoferrin (ELISA) were determined.
  
  
  RESULTS
  In children with mixed and permanent dentition, type 1 diabetes mellitus significantly decreases (as compared with the appropriate controls) the unstimulated salivary flow, the output, concentration of peroxidase and the output of the lysozyme and lactoferrin.
  
  
  CONCLUSIONS
  In conclusion, it may be stated that type 1 diabetes mellitus causes functional changes in the salivary glands, resulting in a decrease of the salivary flow and weakening of the salivary innate defense system, thus creating a threat to the oral and general health of type 1 diabetes mellitus children. The results showed that the salivary glands of younger children, when compared to adolescents with type 1 diabetes mellitus, are more susceptible to the injurious effects of the disease.
authors: Department of Pedodontics.
authors: Anna
authors: A
authors: Zalewska
authors: Małgorzata
authors: M
authors: Knaś
authors: Anna
authors: A
authors: Kuźmiuk
authors: Napoleon
authors: N
authors: Waszkiewicz
authors: Marek
authors: M
authors: Niczyporuk
authors: Danuta
authors: D
authors: Waszkiel
authors: Krzysztof
authors: K
authors: Zwierz
mesh_terms: D000293:Adolescent; D002648:Child; D019229:Dentition, Permanent; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D012463:Saliva / Q000276:immunology*