title: [Prevention of tuberculosis: current approaches to development of vaccines].
abstract: This review is focused on recent advances in development of new vaccines for the prevention of tuberculosis. The main reasons for lack of BCG vaccine efficacy in different populations and geographic regions are presented. Design of new vaccines based on live modified strains of Mycobacterium bovis BCG, attenuated strains of Mycobacterium tuberculosis, recombinant proteins and viral vectors is considered in the specific examples. The usage of the heterologous "prime-boost" vaccination strategy against tuberculosis is discussed.
authors: M A
authors: MA
authors: Stukova
authors: N V
authors: NV
authors: Zabolotnykh
authors: T I
authors: TI
authors: Vinogradova
authors: V Ia
authors: VIa
authors: Gergert
authors: A S
authors: AS
authors: Apt
authors: A S
authors: AS
authors: Kaprel'iants
authors: V V
authors: VV
authors: Erokhin
authors: P K
authors: PK
authors: Iablonskiĭ
authors: O I
authors: OI
authors: Kiselev
mesh_terms: D000818:Animals; D006801:Humans; D014376:Tuberculosis / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000494:pharmacology*; D014611:Vaccination / Q000639:trends*; D014613:Vaccines, Attenuated
chemical_list: D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated