title: [Association of vitamin D receptor gene polymorphisms with Parkinson disease].
abstract: OBJECTIVE
  Vitamin D receptor (VDR) has been proposed as a candidate gene for susceptibility to Parkinson's disease (PD). This study was set to assess the association between VDR gene Apa I and Taq I polymorphisms and PD in a Chinese Han population.
  
  
  METHODS
  Two hundred and eighty five sporadic PD patients and 285 healthy controls were genotyped for the Apa I and Taq I polymorphisms in VDR gene using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  No significant difference was detected in genotype or allele distribution of both Apa I and Taq I polymorphisms between PD patients and controls (P U+003E 0.05). No TT genotype for Taq I was found in the studied population. For Taq I, the distribution of genotype was significantly different between male PD patients and controls (U+03C7 2=4.187, P=0.032, OR=2.149, 95%CI: 1.011-4.567), and the frequency of T allele was significantly higher in male PD patients than male controls (U+03C7 2=3.867, P=0.036, OR=2.064, 95%CI: 0.989-4.307).
  
  
  CONCLUSIONS
  VDR gene Apa I polymorphisms are not associated with sporadic Parkinson's disease, but Taq I may be a risk factor for male PD.
authors: Department of Neurology, Qingdao University, Qingdao, Shandong, People's Republic of China.
authors: Hong-xin
authors: HX
authors: Liu
authors: Xun
authors: X
authors: Han
authors: Xue-ping
authors: XP
authors: Zheng
authors: Yong-sheng
authors: YS
authors: Li
authors: An-mu
authors: AM
authors: Xie
mesh_terms: D000368:Aged; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012737:Sex Factors
chemical_list: D018167:Receptors, Calcitriol