title: Fluorine-18 labeling by click chemistry: multiple probes in one pot.
abstract: Click chemistry has been widely applied in drug development including radiopharmaceuticals and has shown great advantages. Here we reported a novel strategy for rapid preparation of multiple (18)F labeled PET probes in one pot using the 'Click Reaction' of Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of terminal alkynes and organic azides (CuAAC). Preliminary results showed its high efficiency and potential for speeding up the preclinical screening of PET probes.
authors: Shanghai Institute of Applied Physics (SINAP), Chinese Academy of Sciences, PR China.
authors: Lina
authors: L
authors: Jia
authors: Zhen
authors: Z
authors: Cheng
authors: Lingli
authors: L
authors: Shi
authors: Jianbo
authors: J
authors: Li
authors: Cheng
authors: C
authors: Wang
authors: Dawei
authors: D
authors: Jiang
authors: Wei
authors: W
authors: Zhou
authors: Hu
authors: H
authors: Meng
authors: Yujin
authors: Y
authors: Qi
authors: Dengfeng
authors: D
authors: Cheng
authors: Lan
authors: L
authors: Zhang
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D057930:Click Chemistry; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: C522266:2-fluoroethylazide; D000480:Alkynes; D001386:Azides; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals