title: Enhanced bioavailability of total paeony glycoside by self-microemulsifying drug delivery system.
abstract: Total paeony glycoside (TPG) is extracted and purified from a traditional Chinese herbal medicine. It has many biological and pharmacological activities. However, there are few dosage forms of TPG in the market because of its low bioavailability. Self-microemulsifying drug delivery system (SMEDDS) is a vital tool in solving low bioavailability of poor absorption drugs. So the objective of this study is to develop a new TPG-SMEDDS for the oral delivery of poorly soluble TPG. Through the construction of pseudo-ternary phase diagrams, the optimum prescription was obtained, which consisted of 18.70% TPG, 16.27% ethyl oleate as oil, 43.34% Cremophor RH40 as surfactant and 21.73% Transcutol P as cosurfactant. The characterizations of TPG-SMEDDS including morphological characterization, droplet size, zeta-potential, emulsification time, and dissolution study of TPG-SMEDDS were evaluated. The results showed that TPG-SMEDDS is stable and its release rate is high in four different media (0.1 mol x L(-1) HCl, pH 6.8 PBS, pH 7.4 PBS, and water). The relative bioavailability of SMEDDS was dramatically enhanced in an average of 1.52-fold that of TPG-suspension. It is concluded that the bioavailability of TPG is enhanced greatly by SMEDDS.
authors: College of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, China. chlj16@163.com
authors: Li-Jiang
authors: LJ
authors: Chen
authors: Yang
authors: Y
authors: Liu
authors: Yu
authors: Y
authors: Liu
authors: Li
authors: L
authors: Li
authors: Fei
authors: F
authors: Gao
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D005026:Ethylene Glycols / Q000737:chemistry; D006027:Glycosides / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics*; D009829:Oleic Acids / Q000737:chemistry; D029596:Paeonia / Q000737:chemistry*; D010316:Particle Size; D014677:Pharmaceutical Vehicles / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D012995:Solubility
chemical_list: D004655:Emulsions; D005026:Ethylene Glycols; D006027:Glycosides; D009829:Oleic Acids; D014677:Pharmaceutical Vehicles; C022131:cremophor; D011092:Polyethylene Glycols; C010111:carbitol; C033180:ethyl oleate