title: Low-dose recombinant activated factor VII temporally stopped bleeding from small artery in severe postpartum hemorrhage: a case report.
abstract: Recombinant activated factor VII has been used to effectively treat uncontrolled massive hemorrhage at parturition in an off-label manner. Interventional radiology, including vessel embolization of the internal iliac artery or uterine artery for postpartum hemorrhage, is now familiar to obstetricians. However, this therapeutic technique is applicable only in patients who are hemodynamically stable. We encountered a case with severe and uncontrolled postpartum bleeding from the vaginal fornix. The patient received a low dose (<20 μg/kg) of factor VIIa and subsequently underwent vessel embolization. We herein report that this stepwise treatment was very effective for uncontrolled bleeding.
authors: Perinatal Care Center, Department of Obstetrics and Gynecology, Akita University Hospital, Hondo, Akita, Japan. ogawapen@boshi.twmu.ac.jp
authors: Masaki
authors: M
authors: Ogawa
authors: Saeko
authors: S
authors: Akahira
authors: Satoshi
authors: S
authors: Takahashi
authors: Yuki
authors: Y
authors: Shimoda
authors: Megumi
authors: M
authors: Sato
authors: Akira
authors: A
authors: Sato
authors: Yukihiro
authors: Y
authors: Terada
mesh_terms: D000328:Adult; D004621:Embolization, Therapeutic; D015942:Factor VIIa / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007083:Iliac Artery / Q000187:drug effects* / Q000601:surgery; D006473:Postpartum Hemorrhage / Q000188:drug therapy* / Q000601:surgery; D011247:Pregnancy; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D015942:Factor VIIa