title: [8.5 year-follow-up of combined heart-lung transplantation in a patient].
abstract: To summarize the case of combined heart-lung transplantation for a patient who survived for 8.5 years. On September 20, 2003, at Second Xiangya Hospital of Central South University, homologous heartlung transplantation was performed on a male patient who was diagnosed with cardiopulmonary failure secondary to congenital ventricular septal defect with severe pulmonary hypertension. Heart-lung allograft was preserved with 1500 mL modified St.Thomas solution and 3000 mL modified LPD solution. Postoperative immunosuppressive therapies included: methylprednisolone and human anti-lymphocyte globulin protein in the induction period; and combination of ciclosporin A, CellCept and prednisolone in the stable period. In 2007, the treatment was changed to CellCept mg, twice a day+FK506 4 mg, twice a day. The patient lived 8.5 years of normal life with cardiac function of NYHA I-II. Echocardiogram showed left ventricular ejection fraction of 61% to 74%. Heart-lung transplantation proved reliable therapy modality for terminal cardiopulmonary failure. Excellent donor organ preservation and proper perioperative treatment are key factors for long-term survival after heart-lung transplantation.
authors: Department of Thoracic and Cardiovascular Surgery, Central South University, Changsha, China.
authors: Baopeng
authors: B
authors: Shang
authors: Jianguo
authors: J
authors: Hu
authors: Xinmin
authors: X
authors: Zhou
authors: Wei
authors: W
authors: Zhang
authors: Xiaobo
authors: X
authors: Liao
authors: Jianming
authors: J
authors: Li
mesh_terms: D004541:Eisenmenger Complex / Q000601:surgery; D005500:Follow-Up Studies; D006084:Graft Rejection; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000601:surgery*; D016041:Heart-Lung Transplantation / Q000379:methods*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000601:surgery*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents