title: Differentiation of complex vapor mixtures using versatile DNA-carbon nanotube chemical sensor arrays.
abstract: Vapor sensors based on functionalized carbon nanotubes (NTs) have shown great promise, with high sensitivity conferred by the reduced dimensionality and exceptional electronic properties of the NT. Critical challenges in the development of NT-based sensor arrays for chemical detection include the demonstration of reproducible fabrication methods and functionalization schemes that provide high chemical diversity to the resulting sensors. Here, we outline a scalable approach to fabricating arrays of vapor sensors consisting of NT field effect transistors functionalized with single-stranded DNA (DNA-NT). DNA-NT sensors were highly reproducible, with responses that could be described through equilibrium thermodynamics. Target analytes were detected even in large backgrounds of volatile interferents. DNA-NT sensors were able to discriminate between highly similar molecules, including structural isomers and enantiomers. The sensors were also able to detect subtle variations in complex vapors, including mixtures of structural isomers and mixtures of many volatile organic compounds characteristic of humans.
authors: Department of Physics and Astronomy and Nano/Bio Interface Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
authors: Nicholas J
authors: NJ
authors: Kybert
authors: Mitchell B
authors: MB
authors: Lerner
authors: Jeremy S
authors: JS
authors: Yodh
authors: George
authors: G
authors: Preti
authors: A T Charlie
authors: AT
authors: Johnson
mesh_terms: D015374:Biosensing Techniques; D053138:Cyclohexenes / Q000032:analysis / Q000737:chemistry; D004277:DNA, Single-Stranded / Q000737:chemistry; D045782:Hemiterpenes; D006801:Humans; D000077222:Limonene; D036103:Nanotechnology; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010421:Pentanoic Acids / Q000032:analysis; D055672:Static Electricity; D013237:Stereoisomerism; D013729:Terpenes / Q000032:analysis / Q000737:chemistry; D013816:Thermodynamics; D055549:Volatile Organic Compounds / Q000032:analysis* / Q000737:chemistry
chemical_list: D053138:Cyclohexenes; D004277:DNA, Single-Stranded; D045782:Hemiterpenes; D037742:Nanotubes, Carbon; D010421:Pentanoic Acids; D013729:Terpenes; D055549:Volatile Organic Compounds; C008216:isovaleric acid; D000077222:Limonene