title: The effect of acetaminophen ingestion on cortico-spinal excitability.
abstract: Acetaminophen (ACT) facilitates the inhibition of voltage-gated calcium and sodium currents, which may effect cortico-spinal excitability. Twelve subjects ingested acetaminophen or a placebo and underwent transcranial magnetic stimulation to assess the motor evoked potential (MEP), and cortical silent period (CSP). ACT significantly increased MEP response (P > 0.05) but had no effect on CSP (P > 0.05). This indicates that ACT increases MEP and should be controlled for in studies where these measures are of interest.
authors: Endurance Research Group, School of Sport and Exercise Sciences, Faculty of Science, University of Kent, Kent, England.
authors: Alexis R
authors: AR
authors: Mauger
authors: James G
authors: JG
authors: Hopker
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000494:pharmacology*; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001931:Brain Mapping; D004311:Double-Blind Method; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000187:drug effects*; D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000294:innervation; D011597:Psychomotor Performance / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects; D013127:Spinal Nerves / Q000187:drug effects* / Q000502:physiology; D050781:Transcranial Magnetic Stimulation
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen