title: Correlation of spectral domain optical coherence tomography characteristics with visual acuity in eyes with subfoveal scarring after treatment for wet age-related macular degeneration.
abstract: OBJECTIVE
  Correlating spectral domain optical coherence tomography characteristics with final best-corrected visual acuity (BCVA) in eyes with subfoveal scarring after treatment for wet age-related macular degeneration.
  
  
  METHODS
  Seventy-nine eyes from 64 subjects, who developed subfoveal scarring after treatment of wet age-related macular degeneration, were retrospectively studied. Spectral domain optical coherence tomography characteristics were analyzed, including percentage disruption of inner segment/outer segment junction and external limiting membrane, central macular thickness, subfoveal scar thickness, subretinal scar area, and proximity of retina with intact outer structures to the fovea. A multivariate stepwise regression analysis was performed with the final BCVA logarithm of minimum angle of resolution as a response and the above-identified spectral domain optical coherence tomography variables as predictors.
  
  
  RESULTS
  There was no correlation between the final BCVA and any of the demographic data, treatment modality received, and central macular thickness. The final BCVA was significantly correlated with the percentage of inner segment/outer segment disruption (P = 0.011), external limiting membrane disruption (P = 0.005), and scar area on spectral domain optical coherence tomography (P = 0.018). Multivariate analysis showed that the baseline BCVA and distance between the fovea and nearest retina with intact outer structures are the most predictive of the final BCVA (R(2) = 0.52).
  
  
  CONCLUSIONS
  Baseline BCVA and integrity of outer retinal structures are good predictors of the final BCVA of wet age-related macular degeneration patients developing scarring after treatment.
authors: Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Center, University of California San Diego, La Jolla, California 92037, USA.
authors: Sharif
authors: S
authors: El-Emam
authors: Jay
authors: J
authors: Chhablani
authors: Giulio
authors: G
authors: Barteselli
authors: Haiyan
authors: H
authors: Wang
authors: Su Na
authors: SN
authors: Lee
authors: Igor
authors: I
authors: Kozak
authors: Lingyun
authors: L
authors: Cheng
authors: William R
authors: WR
authors: Freeman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002921:Cicatrix / Q000473:pathology*; D019773:Epiretinal Membrane / Q000473:pathology; D005260:Female; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D015999:Multivariate Analysis; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000502:physiology*; D057135:Wet Macular Degeneration / Q000473:pathology / Q000503:physiopathology