title: Vibration enhances clearance of solutes with varying molecular weights during in vitro hemodialysis.
abstract: This proof of concept pilot study was performed to determine whether vibration can increase solute clearance when applied to an in vitro dialysis model. Urea, creatinine, gentamicin, and vancomycin transmembrane clearances were calculated at a blood flow rate of 200 ml/min, dialysate flow rates of 2 and 8 L/hr, and no concurrent ultrafiltration at various vibration intensities. Dialyzer integrity was determined by measuring transmembrane pressure, filter drop pressure, and albumin clearance, and by visually inspecting the dialysate. Comparing the highest vibration modality with no vibration, the median percentage increase in urea, creatinine, gentamicin, and vancomycin clearance was 18% (all p < 0.005). The transmembrane clearance of albumin was negligible for all experiments. When measuring transmembrane pressure and filter drop pressure, no significant differences were found between nonvibration and vibration dialysis. The addition of vibration during dialysis increased transmembrane clearance for solutes with molecular weights of 60-1450 Daltons.
authors: Department of Clinical, Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA. muellerb@umich.edu
authors: Bruce A
authors: BA
authors: Mueller
authors: Karalea D
authors: KD
authors: Jasiak
authors: Sarah R
authors: SR
authors: Thiel
authors: James M
authors: JM
authors: Stevenson
authors: A Mary
authors: AM
authors: Vilay
authors: Bridget A
authors: BA
authors: Scoville
authors: Mariann D
authors: MD
authors: Churchwell
authors: Deborah A
authors: DA
authors: Pasko
authors: Noel
authors: N
authors: Perkins
mesh_terms: D003404:Creatinine / Q000097:blood; D005839:Gentamicins / Q000097:blood; D006801:Humans; D008970:Molecular Weight; D006435:Renal Dialysis; D014640:Vancomycin / Q000097:blood; D014732:Vibration
chemical_list: D005839:Gentamicins; D014640:Vancomycin; D003404:Creatinine