title: Diastereoselective synthesis of indanes and tetralins via intramolecular Friedel-Crafts reaction.
abstract: An easy access to tetralin and indane skeletons has been developed using a diastereoselective intramolecular Friedel-Crafts alkylation. Treatment of diastereomeric mixtures of benzyl carbinols with a catalytic amount of Ca(NTf2)2/Bu4NPF6 yields the respective tetralin or indane in good yields with high levels of regio- and diastereoselectivity.
authors: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
authors: Jeanne-Marie
authors: JM
authors: Begouin
authors: Francesca
authors: F
authors: Capitta
authors: Xian
authors: X
authors: Wu
authors: Meike
authors: M
authors: Niggemann
mesh_terms: D000478:Alkylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007189:Indans; D013764:Tetrahydronaphthalenes