title: Immunotherapy of allergic diseases using probiotics or recombinant probiotics.
abstract: Allergic diseases affect up to 30% of the western population, and their prevalence is increasing. Probiotics are able to modulate the mucosal immune response, and clinical trials demonstrated that specific strains, especially lactic acid bacteria (LAB) ones, reduce allergic symptoms. Moreover, the use of recombinant probiotics has been evaluated as possible strategies for the immunotherapy of allergic diseases. The production and delivery of allergens by recombinant LAB in concert with their ability to induce a Th1-type immune response have been shown to be a promising mucosal vaccination strategy in mouse model. The aim of this article is to review the applications of probiotics in allergy immunotherapy with a special focus on recombinant LAB delivering proteins or DNA.
authors: Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (ICB/UFMG), Belo Horizonte, MG, Brazil.
authors: M S P
authors: MS
authors: de Azevedo
authors: S
authors: S
authors: Innocentin
authors: F A
authors: FA
authors: Dorella
authors: C S
authors: CS
authors: Rocha
authors: D
authors: D
authors: Mariat
authors: D S
authors: DS
authors: Pontes
authors: A
authors: A
authors: Miyoshi
authors: V
authors: V
authors: Azevedo
authors: P
authors: P
authors: Langella
authors: J-M
authors: JM
authors: Chatel
mesh_terms: D000485:Allergens / Q000235:genetics / Q000276:immunology; D000818:Animals; D001644:Bifidobacterium / Q000235:genetics; D004247:DNA / Q000008:administration & dosage; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*; D018928:Immunity, Mucosal; D007167:Immunotherapy; D007778:Lactobacillus / Q000235:genetics; D051379:Mice; D016269:Milk Hypersensitivity / Q000628:therapy; D019936:Probiotics / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000485:Allergens; D011994:Recombinant Proteins; D004247:DNA
keywords: allergic diseases; allergy treatment; immunotherapy; lactic acid bacteria; recombinant probiotics; β-lactoglobulin