title: Topical treatment of tinea pedis using 6% coriander oil in unguentum leniens: a randomized, controlled, comparative pilot study.
abstract: BACKGROUND
  The antifungal activity of coriander oil has already been demonstrated in vitro.
  
  
  OBJECTIVE
  Evaluation of the efficacy and tolerability of 6% coriander oil in unguentum leniens in the treatment of interdigital tinea pedis.
  
  
  METHODS
  Half-side comparative pilot study on subjects with symmetric, bilateral interdigital tinea pedis. Active drug and placebo control were applied twice daily on the affected areas, and follow-up visits were performed on days 14 and 28.
  
  
  RESULTS
  40 participants (mean age 52.5 years, 60% male) were included in the study. For 6% coriander oil in unguentum leniens, a highly significant improvement of the clinical signs (p < 0.0001) was observed during the entire observation period; the number of positive fungal cultures also tended to decrease (p = 0.0654). The tolerability of the tested substances was good.
  
  
  CONCLUSIONS
  Coriander oil is effective and well tolerated in the treatment of interdigital tinea pedis.
authors: Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg, DE–20246 Hamburg, Germany.
authors: F C
authors: FC
authors: Beikert
authors: Z
authors: Z
authors: Anastasiadou
authors: B
authors: B
authors: Fritzen
authors: U
authors: U
authors: Frank
authors: M
authors: M
authors: Augustin
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002175:Candida / Q000302:isolation & purification; D028526:Coriandrum / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments / Q000008:administration & dosage; D008517:Phytotherapy / Q000379:methods*; D010865:Pilot Projects; D010938:Plant Oils / Q000008:administration & dosage* / Q000009:adverse effects; D014008:Tinea Pedis / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D014249:Trichophyton / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D009824:Ointments; D010938:Plant Oils