title: A novel norovirus recombinant strain GII.4/GII.21 in Bangladesh, 2011.
abstract: We identified a novel inter-genotype recombinant norovirus strain, Dhaka85/2011/BGD, collected from a stool specimen of a nine-month-old infant who was hospitalized with diarrhea. Molecular investigation and phylogenetic analysis classified its RNA polymerase gene as GII.4-like, which commonly circulates in humans. The capsid gene was classified as GII.21-like, most likely originated from water. The discovery of this novel strain is an illustration of the enormous diversity among the norovirus strains, especially in developing countries and has important implications for future vaccine strategies.
authors: Department of Microbiology, Jahangirnagar University, Savar, Dhaka, Bangladesh.
authors: Shamsun
authors: S
authors: Nahar
authors: Mokibul Hassan
authors: MH
authors: Afrad
authors: Tazin
authors: T
authors: Fahmi
authors: Sayra
authors: S
authors: Moni
authors: Warda
authors: W
authors: Haque
authors: Sumon Kumar
authors: SK
authors: Das
authors: Abu Syed Golam
authors: AS
authors: Faruque
authors: Mohammad Sahabuddin Kabir
authors: MS
authors: Choudhuri
authors: Tasnim
authors: T
authors: Azim
authors: Mustafizur
authors: M
authors: Rahman
mesh_terms: D001459:Bangladesh; D017250:Caliciviridae Infections / Q000821:virology; D036022:Capsid Proteins / Q000235:genetics; D016000:Cluster Analysis; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000821:virology; D006801:Humans; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D029322:Norovirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D036022:Capsid Proteins; D012367:RNA, Viral; D012321:DNA-Directed RNA Polymerases