title: Mechanism of experimental autoimmune neuritis in Lewis rats: the dual role of macrophages.
abstract: Human peripheral demyelinating diseases, such as Guillain-Barré syndrome (GBS), are characterized by inflammation and demyelination in the peripheral nervous system. Similarities in the pathology between GBS and the animal model of experimental autoimmune neuritis (EAN) indicate that autoimmune responses are involved in both diseases. This article summarizes the general aspects of the EAN model in Lewis rats and discusses the potential role of macrophages in the progression of EAN. A better understanding of macrophages may help to design alternative therapeutic strategies for organ-specific autoimmune diseases, including GBS.
authors: Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, Republic of Korea. shint@jejunu.ac.kr
authors: Taekyun
authors: T
authors: Shin
authors: Meejung
authors: M
authors: Ahn
authors: Yoh
authors: Y
authors: Matsumoto
authors: Changjong
authors: C
authors: Moon
mesh_terms: D000818:Animals; D018450:Disease Progression; D020275:Guillain-Barre Syndrome / Q000276:immunology / Q000473:pathology*; D008262:Macrophage Activation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology*; D009928:Organ Specificity; D051381:Rats; D011917:Rats, Inbred Lew