title: [Norovirus epidemic strain GII. 4 evolution--a review].
abstract: Noroviruses are regarded as the leading cause of epidemic gastroenteritis all over the world, with a wealth of genetic diversity. And GII. 4 is regarded as the predominant strain, which has constantly infected humans attributed to a fast rate of evolution in the past two decades. With the discovery of virus binding-receptor and understanding of immune specificity, the research of evolution mechanism of the virus has been continuously developed recently. It has been hypothesized that the receptor switching and antigenic drift maintains GII. 4 persistence in human populations. Also the RNA viruses, high mutation rate and the limited space of genomic variation have also affected the direction of norovirus evolution.
authors: Guangdong Institute of Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, China. wuqp203@yahoo.com.cn
authors: Qingping
authors: Q
authors: Wu
authors: Liang
authors: L
authors: Xue
authors: Jumei
authors: J
authors: Zhang
mesh_terms: D000818:Animals; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000821:virology*; D058872:Epidemics; D019143:Evolution, Molecular; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D029322:Norovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny