title: Neonatal toxicity following maternal citalopram treatment.
abstract: Late gestational exposure to citalopram, may be associated with a neonatal toxicity syndrome with immediate onset at birth or soon after birth and sometimes may be mistaken for neonatal withdrawal syndrome. A 3860 g infant was delivered at 40 weeks gestation. The mother had been taking citalopram 20 mg/day until the day of delivery. Fifteen minutes after birth, the baby became hypertonic. Neonatal serotonin toxicity due to citalopram seems the most likely mechanism, though an important differential diagnosis is a citalopram withdrawal syndrome. We suggest the hypothesis that neonatal withdrawal syndrome may follow citalopram serotonin toxicity.
authors: Poison Control Centre and Teratology Information Service, Ospedali Riuniti, Bergamo, Italy. geleftheriou@hpg23.it
authors: Georgios
authors: G
authors: Eleftheriou
authors: Raffaella
authors: R
authors: Butera
authors: Federica
authors: F
authors: Cotti Cottini
authors: Maurizio
authors: M
authors: Bonati
authors: Marialuisa
authors: M
authors: Farina
mesh_terms: D015283:Citalopram / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000097:blood; D003865:Major Depressive Disorder / Q000150:complications / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009357:Neonatal Abstinence Syndrome / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000175:diagnosis; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000097:blood
chemical_list: D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors; C046304:desmethylcitalopram