title: Sensitivity enhanced nanothermal sensors for photoacoustic temperature mapping.
abstract: Photoacoustic imaging can be used to guide and validate the therapeutic outcome of nanoparticle-mediated photothermal therapy through its ability to visualize the delivery of nanoparticle contrast agents, image the temperature distribution inside living tissue, and confirm tissue coagulation. In this image-guided process, temperature mapping plays a critical role for thermal dosage control. Therefore, developing a sensitive and accurate photoacoustic technique to quantitatively measure the temperature distribution during thermal therapy is essential. In this study, we investigated and demonstrated that silica-coated gold nanorods, can provide a multi-fold improvement in sensitivity of the photoacoustic temperature mapping compared to gold nanorods without silica coating, and serve as a nanothermal sensor to accurately and quantitatively visualize temperature distributions during photothermal therapy.
authors: Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA.
authors: Yun-Sheng
authors: YS
authors: Chen
authors: Wolfgang
authors: W
authors: Frey
authors: Charles
authors: C
authors: Walker
authors: Salavat
authors: S
authors: Aglyamov
authors: Stanislav
authors: S
authors: Emelianov
mesh_terms: D006046:Gold / Q000737:chemistry; D043942:Nanotubes; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013696:Temperature
chemical_list: D011092:Polyethylene Glycols; D006046:Gold; D012822:Silicon Dioxide