title: Functional aspects of PARylation in induced and programmed DNA repair processes: preserving genome integrity and modulating physiological events.
abstract: To cope with the devastating insults constantly inflicted to their genome by intrinsic and extrinsic DNA damaging sources, cells have evolved a sophisticated network of interconnected DNA caretaking mechanisms that will detect, signal and repair the lesions. Among the underlying molecular mechanisms that regulate these events, PARylation catalyzed by Poly(ADP-ribose) polymerases (PARPs), appears as one of the earliest post-translational modification at the site of the lesion that is known to elicit recruitment and regulation of many DNA damage response proteins. In this review we discuss how the complex PAR molecule operates in stress-induced DNA damage signaling and genome maintenance but also in various physiological settings initiated by developmentally programmed DNA breakage. To illustrate the latter, particular emphasis will be placed on the emerging contribution of PARPs to B cell receptor assembly and diversification.
authors: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de Santé et de Recherche Médicale (INSERM), Centre National de Recherche Scientifique (CNRS), UMR 7104, Université de Strasbourg, 67404 Illkirch, France.
authors: Isabelle
authors: I
authors: Robert
authors: Olga
authors: O
authors: Karicheva
authors: Bernardo
authors: B
authors: Reina San Martin
authors: Valérie
authors: V
authors: Schreiber
authors: Françoise
authors: F
authors: Dantzer
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D016678:Genome / Q000502:physiology*; D006801:Humans; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
chemical_list: D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases
keywords: B cell receptor assembly and diversification; DNA repair; Developmentally programmed DNA damage; Genome integrity; Poly(ADP-ribose) polymerases; Stress-induced DNA damage