title: In vivo binding of the dopamine-1 receptor PET tracers [¹¹C]NNC112 and [¹¹C]SCH23390: a comparison study in individuals with schizophrenia.
abstract: BACKGROUND
  A deficit in dopamine-1 (D1) receptor function in the prefrontal cortex is suggested to play a role in the cognitive dysfunction observed in patients with schizophrenia. However, the results from positron emission tomography imaging studies of D1 receptor levels in individuals with schizophrenia are mixed.
  
  
  OBJECTIVE
  The aim of this investigation was to determine whether the in vivo characteristics of the different D1 receptor tracers used in previous reports, [(11)C]SCH23390 and [(11)C]NNC112, may have contributed to these discrepancies reported in the literature.
  
  
  METHODS
  Eight patients with schizophrenia and 12 healthy control subjects were scanned with both [(11)C]SCH23390 and [(11)C]NNC112.
  
  
  RESULTS
  [(11)C]SCH23390 and [(11)C]NNC112 binding potentials in both patients and control subjects were compared and no tracer by diagnosis interactions were observed.
  
  
  CONCLUSIONS
  The results of this study suggest that differences in the binding of [(11)C]SCH23390 and [(11)C]NNC112 observed in previous studies are not due to differences in the in vivo behavior of these tracers.
authors: Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA. 318388ep@student.eur.nl
authors: Eline M P
authors: EM
authors: Poels
authors: Ragy R
authors: RR
authors: Girgis
authors: Judy L
authors: JL
authors: Thompson
authors: Mark
authors: M
authors: Slifstein
authors: Anissa
authors: A
authors: Abi-Dargham
mesh_terms: D000293:Adolescent; D000328:Adult; D001552:Benzazepines / Q000378:metabolism*; D001572:Benzofurans / Q000378:metabolism*; D002250:Carbon Radioisotopes / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals / Q000378:metabolism; D017447:Receptors, Dopamine D1 / Q000378:metabolism; D012559:Schizophrenia / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D001552:Benzazepines; D001572:Benzofurans; D002250:Carbon Radioisotopes; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals; D017447:Receptors, Dopamine D1; C534628:SCH 23390; C077123:NNC 112