title: Human T follicular helper cells: development and subsets.
abstract: Antibody response constitutes one of the key immune protection mechanisms. T follicular helper (Tfh) cells represent the major CD4⁺ T cell subset that provides help to B cells to induce antibody response. How Tfh cells develop and how Tfh cells or their associated subsets regulate antibody response in humans remains largely unknown. In this review, we will summarize the recent discoveries on the biology of Tfh cells, with a particular focus on human Tfh cells.
authors: Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA. nathalis@baylorhealth.edu
authors: Nathalie
authors: N
authors: Schmitt
authors: Hideki
authors: H
authors: Ueno
mesh_terms: D000917:Antibody Formation; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation; D015870:Gene Expression; D018858:Germinal Center / Q000166:cytology* / Q000276:immunology; D006801:Humans; D014066:Palatine Tonsil / Q000166:cytology* / Q000276:immunology; D054380:Receptors, CXCR5 / Q000235:genetics / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000276:immunology
chemical_list: C095085:CXCR5 protein, human; D054380:Receptors, CXCR5