title: Successful treatment of preadolescents with small cell carcinoma of the ovary hypercalcemic type.
abstract: BACKGROUND
  Small cell carcinoma of the ovary hypercalcemic type (SCCOHT) is a rare tumor with a peak incidence in young adulthood that historically has carried a poor prognosis.
  
  
  METHODS
  We present 2 advanced stage cases of SCCOHT in preadolescents successfully treated with a combination of cisplatin-based chemotherapy and surgical resection. The more recent patient also underwent consolidative high-dose chemotherapy with stem cell rescue and external beam radiotherapy. Her therapy was concluded with a maintenance course of bevacizumab. The patients are now disease-free 7 years and 30 months, respectively, after diagnosis.
  
  
  CONCLUSIONS
  With aggressive multimodal therapy SCCOHT is curable in children.
authors: Departments of *Pediatrics, Division of Hematology-Oncology †Pathology and Laboratory Medicine, Children's Hospital of Alabama, University of Alabama at Birmingham, Birmingham, AL.
authors: Joseph G
authors: JG
authors: Pressey
authors: David R
authors: DR
authors: Kelly
authors: Heather T
authors: HT
authors: Hawthorne
mesh_terms: D018288:Carcinoma, Small Cell / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome