title: Anticholinergic agents result in weaker and shorter suppression of uterine contractility compared with intestinal motion: time course observation with cine MRI.
abstract: OBJECTIVE
  To evaluate the time course effects of anticholinergic agents on uterine contractility and intestinal motion with cine magnetic resonance imaging (MRI).
  
  
  METHODS
  Using a 1.5 T MRI scanner, 60 T2-weighted half-Fourier rapid acquisitions with relaxation enhancement images of the uterus were serially acquired over 3 minutes in 25 healthy women in the periovulatory phase, at four instances, prior to and 2-5, 5-8, and 10-13 minutes after intravenous injection of 20 mg of hyoscine butylbromide. Uterine peristalsis frequency (waves / 3 min) and degrees of endometrial transformation, subendometrial conduction, outer myometrial conduction, sporadic myometrial contraction, and intestinal movement were independently evaluated by three readers.
  
  
  RESULTS
  Uterine peristalsis frequency of 6.14 ± 2.34 decreased the most at 2-5 minutes (P < 0.001) by 1.41 (95% confidential interval [CI] = 0.59-2.22), or 23.0% ([6.14-4.73]/6.14) and remained reduced at 5-8 minutes (P = 0.013) by 0.97 (95% CI = 0.15-1.78), or 15.8% ([6.14-5.17]/6.14) after injection. The degree of intestinal movement was 3.32 ± 0.54 and was prominently reduced at every phase (P < 0.001 for all) and maximally decreased to 0.67 ± 0.65 at 5-8 min. It increased to 1.36 ± 0.72 at 10-13 minutes compared with the degrees of motion at 2-5 minutes (P = 0.04) and 5-8 minutes (P = 0.004).
  
  
  CONCLUSIONS
  Suppression of uterine peristalsis was weaker and shorter compared with the stronger and longer suppression of intestinal movement by the intravenous administration of anticholinergic agents.
authors: Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Sayaka
authors: S
authors: Daido
authors: Asako
authors: A
authors: Nakai
authors: Aki
authors: A
authors: Kido
authors: Tomohisa
authors: T
authors: Okada
authors: Toshikazu
authors: T
authors: Kamae
authors: Koji
authors: K
authors: Fujimoto
authors: Isao
authors: I
authors: Ito
authors: Kaori
authors: K
authors: Togashi
mesh_terms: D000328:Adult; D016477:Artifacts; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014590:Uterine Contraction / Q000187:drug effects* / Q000502:physiology*
chemical_list: D018680:Cholinergic Antagonists
keywords: anticholinergic agent; hyoscine butylbromide; peristalsis; uterus