title: Carbon nanotubes in cancer therapy: a more precise look at the role of carbon nanotube-polymer interactions.
abstract: Despite the great potential of carbon nanotubes (CNTs) in various areas of biomedicine, concerns regarding their carcinogenicity, inefficient dispersion in aqueous solutions and biological activity in vivo still remain. One important and feasible route to overcome these barriers is modification of CNTs with polymers, which are widely studied and play a vital role in biological and biomedical fields, especially in drug delivery. This comprehensive review focuses on the achievements of our and other groups in currently used methods to functionalize the surface of CNTs with polymers to produce anticancer drug delivery systems. We have intensively studied covalent and noncovalent interactions between CNTs and linear, dendritic and hyperbranched biocompatible polymers as well as biomacromolecules interactions which are very crucial to diminish the toxicity of CNTs via changing their conformations.
authors: Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, Iran. adeli@sharif.edu
authors: Mohsen
authors: M
authors: Adeli
authors: Rouhollah
authors: R
authors: Soleyman
authors: Zahra
authors: Z
authors: Beiranvand
authors: Fahimeh
authors: F
authors: Madani
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry; D018014:Gene Transfer Techniques; D006801:Humans; D050997:Nanomedicine; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity; D009369:Neoplasms / Q000628:therapy*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D037742:Nanotubes, Carbon; D011108:Polymers