title: Pregnancy outcomes after treatment for cervical intraepithelial neoplasia in a single NHS hospital.
abstract: OBJECTIVE
  The objective of this study was to assess the adverse pregnancy outcomes in women who had treatment for cervical intraepithelial neoplasia.
  
  
  METHODS
  This was a retrospective cohort using data linkage. Pathology databases from Whipps Cross University Hospital were used to identify women with a histological sample taken at colposcopy between 1995 and 2009. Births for these women were identified through the hospitals' obstetric database. A total of 876 births (from 721 women) were identified. Logistic regression was used to assess the relationship between adverse pregnancy outcomes and treatment for cervical intraepithelial neoplasia before delivery. Results were adjusted by ethnicity, deprivation, and parity.
  
  
  RESULTS
  After taking into account parity, socioeconomic status, and ethnicity, receiving any type of excisional treatment (single or multiple) before birth increased the risk of preterm labor compared with having a punch biopsy only (adjusted relative risk, 1.61; 95% confidence interval, 1.11-2.32). Preterm deliveries that occurred after a spontaneous onset of labor were found to be more likely after treatment for cervical disease (adjusted relative risk, 1.68; 95% confidence interval, 1.11-2.52).
  
  
  CONCLUSIONS
  Women receiving any type of excisional treatment before delivery are at increased risk of preterm delivery when compared with women attending colposcopy but not treated. Although we took into account the effects of parity, socioeconomic status, and ethnicity, residual confounding factors may be unidentified.
authors: Whipps Cross University Hospital, London, United Kingdom.
authors: Rekha
authors: R
authors: Wuntakal
authors: Alejandra
authors: A
authors: Castanon
authors: Peter D
authors: PD
authors: Sasieni
authors: Antony
authors: A
authors: Hollingworth
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000191:economics; D003127:Colposcopy / Q000009:adverse effects* / Q000191:economics; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000191:economics / Q000208:ethnology / Q000209:etiology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000191:economics / Q000208:ethnology; D047928:Premature Birth / Q000191:economics / Q000208:ethnology / Q000209:etiology*; D012189:Retrospective Studies; D013222:State Medicine / Q000191:economics; D006113:United Kingdom / Q000208:ethnology; D002583:Uterine Cervical Neoplasms / Q000191:economics / Q000208:ethnology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000191:economics / Q000208:ethnology / Q000601:surgery*