title: A novel fasting blood test for insulin resistance and prediabetes.
abstract: BACKGROUND
  Insulin resistance (IR) can precede the dysglycemic states of prediabetes and type 2 diabetes mellitus (T2DM) by a number of years and is an early marker of risk for metabolic and cardiovascular disease. There is an unmet need for a simple method to measure IR that can be used for routine screening, prospective study, risk assessment, and therapeutic monitoring. We have reported several metabolites whose fasting plasma levels correlated with insulin sensitivity. These metabolites were used in the development of a novel test for IR and prediabetes.
  
  
  METHODS
  Data from the Relationship between Insulin Sensitivity and Cardiovascular Disease Study were used in an iterative process of algorithm development to define the best combination of metabolites for predicting the M value derived from the hyperinsulinemic euglycemic clamp, the gold standard measure of IR. Subjects were divided into a training set and a test set for algorithm development and validation. The resulting calculated M score, M(Q), was utilized to predict IR and the risk of progressing from normal glucose tolerance to impaired glucose tolerance (IGT) over a 3 year period.
  
  
  RESULTS
  M(Q) correlated with actual M values, with an r value of 0.66. In addition, the test detects IR and predicts 3 year IGT progression with areas under the curve of 0.79 and 0.70, respectively, outperforming other simple measures such as fasting insulin, fasting glucose, homeostatic model assessment of IR, or body mass index.
  
  
  CONCLUSIONS
  The result, Quantose(TM), is a simple test for IR based on a single fasting blood sample and may have value as an early indicator of risk for the development of prediabetes and T2DM.
authors: Metabolon Inc., Durham, North Carolina 27713, USA. jcobb@metabolon.com
authors: Jeff
authors: J
authors: Cobb
authors: Walter
authors: W
authors: Gall
authors: Klaus-Peter
authors: KP
authors: Adam
authors: Pamela
authors: P
authors: Nakhle
authors: Eric
authors: E
authors: Button
authors: James
authors: J
authors: Hathorn
authors: Kay
authors: K
authors: Lawton
authors: Michael
authors: M
authors: Milburn
authors: Regis
authors: R
authors: Perichon
authors: Matthew
authors: M
authors: Mitchell
authors: Andrea
authors: A
authors: Natali
authors: Ele
authors: E
authors: Ferrannini
mesh_terms: D000328:Adult; D000465:Algorithms; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007328:Insulin