title: Neuroendocrine differentiation in embryonal type hepatoblastoma.
abstract: Hepatoblastoma, a malignant tumor which arises occasionally in older children but very rarely in adults, exhibits divergent differentiation with embryonal cells, fetal hepatocytes and immature elements. This report describes an embryonal type hepatoblastoma with neuroendocrine differentiation in a 16-year-old patient, which was diagnosed postoperatively. Clinical and radiologic work-up failed to reveal a primary gastrointestinal malignancy and no primary lesions were detected in any other organ. This feature of hepatoblastoma is considered to be a multidirectional differentiation of the small epithelial or stem cells of the liver. At 2-year follow up, the patient remains symptom-free, with normal laboratory and diagnostic imaging studies, and no recurrent or metastatic disease identified.
authors: 2nd Department of Surgery             1st Department of Anesthesia             Department of Pathology             Department of Radiology, Aretaieio Hospital, Medical School, University of Athens, Athens, Greece.
authors: Georgios P
authors: GP
authors: Fragulidis
authors: Konstantinos
authors: K
authors: Chondrogiannis
authors: Antonios
authors: A
authors: Vezakis
authors: Aikaterini
authors: A
authors: Melemeni
authors: Agatha
authors: A
authors: Kondi-Pafiti
authors: Elias
authors: E
authors: Primetis
authors: Andreas
authors: A
authors: Polydorou
authors: Dionysios C
authors: DC
authors: Voros