title: Renal morphologic lesions reminiscent of diabetic nephropathy.
abstract: BACKGROUND
  Nodular, intercapillary glomerulosclerotic lesions resembling Kimmelstiel-Wilson nodules commonly observed in diabetic nephropathy can also be seen in patients without any clinical history or evidence of diabetes.
  
  
  OBJECTIVE
  To discuss the pathobiology of lesions reminiscent of diabetes nephropathy, including light-chain deposition disease, amyloidosis, immunotactoid nephropathy, the membranoproliferative form of glomerulonephritis, and idiopathic nodular glomerulosclerosis, and how to differentiate them from diabetic nephropathy.
  
  
  METHODS
  Published literature and authors' personal experience.
  
  
  CONCLUSIONS
  The well-formed, intercapillary, nodular mesangial lesions, along with thickened glomerular basement membranes and tubular basement membranes, and hyaline arteriolosclerosis are virtually pathognomic of diabetic nephropathy. However, the pathologist must exclude lesions reminiscent of diabetic nephropathy by performing special stains on histologic sections, immunofluorescence, and electron microscopic studies.
authors: Department of Pathology, Northwestern University Medical School, Chicago, IL 60611, USA.
authors: Kirtee
authors: K
authors: Raparia
authors: Irtaza
authors: I
authors: Usman
authors: Yashpal S
authors: YS
authors: Kanwar
mesh_terms: D003928:Diabetic Nephropathies / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*