title: Comparison of effects of 5 and 10 mg oral desloratadine and levocetirizine on histamine-induced wheal and flare response in healthy volunteers.
abstract: BACKGROUND
  Levocetirizine and desloratadine are mostly used as H1-antihistamines in the treatment of allergic disease in 5 and 10 mg doses.
  
  
  OBJECTIVE
  In this study, the efficacy of single oral dosages of 5 and 10 mg desloratadine and levocetirizine were compared by using histamine-induced wheal and flare reactions.
  
  
  METHODS
  Eighty healthy volunteers were randomized for four double-blinded treatment with desloratadine 5 and 10 mg and levocetirizine 5 and 10 mg. Wheal and flare responses were produced by histamine. Measurements were performed just before the ingestion of antihistamines (baseline) and afterward at 30, 60, 240 min and 24 h. The values obtained for each antihistamine were compared with baseline values.
  
  
  RESULTS
  It was found that except the flare reactions at 30th min, levocetirizine 5 and 10 mg suppressed histamine-induced wheal and flare reactions more than desloratadine 5 and 10 mg did. There were not any significant differences between desloratadine 5 and 10 mg in all periods. Levocetirizine 10 mg suppressed wheal and flare reactions significantly more than levocetirizine 5 mg only at 24th h.
  
  
  CONCLUSIONS
  In this study, it was observed that levocetirizine 5 and 10 mg had a higher activity than desloratadine 5 and 10 mg.
authors: Düzce Public Hospital , Düzce , Turkey.
authors: Songül
authors: S
authors: Bulca
authors: Dilek
authors: D
authors: Bayramgürler
authors: Evren
authors: E
authors: Odyakmaz Demirsoy
authors: Melike
authors: M
authors: Yavuz
authors: Aysun
authors: A
authors: Sikar Aktürk
authors: Nilgün
authors: N
authors: Bilen
authors: Rebiay
authors: R
authors: Kıran
mesh_terms: D000284:Administration, Oral; D000328:Adult; D018926:Anti-Allergic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D017332:Cetirizine / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D064368:Healthy Volunteers; D006632:Histamine; D039563:Histamine H1 Antagonists, Non-Sedating / Q000008:administration & dosage*; D006801:Humans; D017336:Loratadine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014581:Urticaria / Q000139:chemically induced / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D018926:Anti-Allergic Agents; D039563:Histamine H1 Antagonists, Non-Sedating; C472067:levocetirizine; D017336:Loratadine; D006632:Histamine; C121345:desloratadine; D017332:Cetirizine