title: Syntheses of the C1-C14 and C15-C25 fragments of amphidinolide C.
abstract: Divergent syntheses of the C1-C14 and C15-C25 fragments of amphidinolide C have been achieved. The synthesis of the C15-C25 fragment featured cobalt-catalyzed modified Mukaiyama aerobic alkenol cyclization and sulfur-directed regiocontrolled Wacker oxidation of an internal alkene. The C1-C14 fragment was established by alkenyllithium addition to an aldehyde followed by a challenging olefination of a highly inert C9 ketone.
authors: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
authors: Dimao
authors: D
authors: Wu
authors: Craig J
authors: CJ
authors: Forsyth
mesh_terms: D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D003500:Cyclization; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D000097442:Amphidinolides
chemical_list: D003035:Cobalt; D018942:Macrolides; C429132:amphidinolide C; D000097442:Amphidinolides