title: One-pot syntheses of isoquinolin-3-ones and benzo-1,4-diazepin-2,5-diones utilizing Ugi-4CR post-transformation strategy.
abstract: One-pot and efficient syntheses of structurally diverse isoquinolin-3-ones and isoquinolin-3-one-based benzo-1,4-diazepin-2,5-diones have been developed. The notable features of the process include the Ugi condensation of monomasked phthalaldehydes with amines, carboxylic acids, and isonitriles, followed by HClO4-mediated intramolecular condensation of the carbonyl with amide.
authors: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China. chec@pkusz.edu.cn
authors: Chao
authors: C
authors: Che
authors: Song
authors: S
authors: Li
authors: Zhixiong
authors: Z
authors: Yu
authors: Fangfang
authors: F
authors: Li
authors: Shengchang
authors: S
authors: Xin
authors: Liyan
authors: L
authors: Zhou
authors: Shuo
authors: S
authors: Lin
authors: Zhen
authors: Z
authors: Yang
mesh_terms: D000577:Amides / Q000737:chemistry; D001569:Benzodiazepines / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D009764:o-Phthalaldehyde / Q000737:chemistry
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D007546:Isoquinolines; D009570:Nitriles; D001569:Benzodiazepines; D009764:o-Phthalaldehyde; C468549:Bz-423