title: Rapid on-site evaluation and low registration error enhance the success of electromagnetic navigation bronchoscopy.
abstract: BACKGROUND
  Electromagnetic navigation bronchoscopy (EMN) is a novel technology which allows localizing peripheral lung lesions and mediastinal lymph nodes for sampling and thus increasing diagnostic yield of Flexible Bronchoscopy.
  
  
  OBJECTIVE
  A prospective study was conducted to investigate the diagnostic yield of EMN with lower average fiducial target registration error (AFTRE) and rapid on-site evaluation (ROSE).
  
  
  METHODS
  Consecutive patients with peripheral lung lesion (PL) or enlarged mediastinal lymph node (MLN) which could not be diagnosed by conventional techniques and/or if the patients were not suitable for such interventions were included. The navigation procedure was continued once registration error was reached below/equal to the absolute value of 5 mm. ROSE was performed by an expert cytopathologist.
  
  
  RESULTS
  A total of 76 patients; 22 having only PLs, 41 having only MLNs, and 13 having both PLs and MLNs together were enrolled. Thirty-two of 35 PLs (91.4%) and 85 of 102 MLNs (83.3%) were successfully sampled. Overall diagnostic yield was 89.5%. PLs and MLNs were further grouped according to their size (PLs: <20 mm vs ≥20 mm, MLNs: <15 mm vs ≥15 mm). The sampling yield was independent of size for both PL and MLN (P = 1.00, P = 0.38). In diagnostic EMN cases, mean AFTRE was 4.33 ± 0.71 mm, whereas it was 5.16 ± 0.05 mm (P = 0.008) in nondiagnostics. The total duration of procedure was 36.17 ± 9.13 min. Pneumothorax was observed in three patients (3.9%).
  
  
  CONCLUSIONS
  EMN with low AFTRE in combination with ROSE is a reliable method with high sampling and/or diagnostic rate in PLs and MLNs.
authors: Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey.
authors: Demet
authors: D
authors: Karnak
authors: Aydin
authors: A
authors: Ciledağ
authors: Koray
authors: K
authors: Ceyhan
authors: Cetin
authors: C
authors: Atasoy
authors: Serdar
authors: S
authors: Akyar
authors: Oya
authors: O
authors: Kayacan
keywords: Electromagnetic navigation bronchoscopy; mediastinal lymph node; peripheral lung lesion