title: Toxicity, analgesic and anti-inflammatory activities of tectorigenin.
abstract: OBJECTIVE
  Belamcanda chinensis has been used in oriental medicine for the treatment of inflammatory diseases. Tectorigenin is a main compound in B. chinensis and possess inhibitory activity against inflammatory responses. Thus, the current study aimed at evaluating toxicity as well as analgesic and anti-inflammatory effects of tectorigenin in animal models.
  
  
  METHODS
  Tectorigenin was employed to evaluate acute and subacute toxicity. Acetic acid-induced writhing in mice was used for analgesic test. The anti-inflammatory activity was tested in carrageenan-induced paw edema.
  
  
  RESULTS
  LD(50) of tectorigenin was 1.78 g/kg p.o. in mice and no toxic symptoms were observed at doses up to 300 mg/kg in a subacute toxicity test during 28-day treatment. Tectorigenin at doses of 50 and 100 mg/kg had an analgesic effect on acetic acid-induced acute visceral pain in mice. In inflammatory rat model, tectorigenin at 60 mg/kg significantly reduced carrageenan-induced edema.
  
  
  CONCLUSIONS
  We demonstrated that tectorigenin is a safe and promising analgesic and anti-inflammatory agent.
authors: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam. halm2vn@gmail.com
authors: Le Minh
authors: le M
authors: Ha
authors: Do Thi Nguyet
authors: do TN
authors: Que
authors: Do Thi Thanh
authors: do TT
authors: Huyen
authors: Pham Quoc
authors: PQ
authors: Long
authors: Nguyen Tien
authors: NT
authors: Dat
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity*; D004487:Edema / Q000188:drug therapy; D005260:Female; D027621:Iridaceae / Q000737:chemistry*; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D008518:Medicine, East Asian Traditional; D051379:Mice; D010146:Pain / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome / Q000737:chemistry; D023382:Toxicity Tests, Acute; D059551:Toxicity Tests, Subacute
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007529:Isoflavones; C120039:tectorigenin