title: [Pyschotherapygenetics. Do genes influence psychotherapy adherence?].
abstract: OBJECTIVE
  There is probably an association between genetic factors, personality traits and response to psychotherapy. We propose the new concept of "psychotherapygenetics" as a strategy to study how genetic factors may influence psychotherapeutic response. The aim was to examine the association between polymorphisms of the serotonin transporter gene (SERT) and the dopamine 4-receptor gene (DRD4) with adherence to psychotherapy.
  
  
  METHODS
  We performed a prospective study of 110 patients with borderline personality disorder (BPD) who participated in dialectical behavioral therapy (DBT). Three polymorphisms were examined: the 5-HTTLPR and the VNTR on the SERT gene and the 7-repeat allele (D4.7) on the DRD4 gene. The dropout rate and the mean number of sessions attended were used as an adherence index.
  
  
  RESULTS
  The presence of the 12-repeat allele on the VNTR polymorphism of SERT was associated with higher adherence to psychotherapy. There was no significant association between the 5-HTTLPR or D4.7 polymorphisms and adherence.
  
  
  CONCLUSIONS
  Our preliminary results show a correlation between certain genetic variations and adherence to DBT in patients with BPD. A "psychotherapygenetics" approach could be useful to study how genetic variables may influence patients' psychotherapy response.
authors: Departamento de Psiquiatría, Hospital de la Santa Creu i Sant Pau, Barcelona, España; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universidad Autónoma de Barcelona, Barcelona, España.
authors: Víctor
authors: V
authors: Pérez
authors: Juan Carlos
authors: JC
authors: Pascual
authors: Joaquim
authors: J
authors: Soler
authors: Thais
authors: T
authors: Tiana
authors: Anna
authors: A
authors: Cortés
authors: Montserrat
authors: M
authors: Baiget
authors: Ana
authors: A
authors: Martín-Blanco
authors: Enrique
authors: E
authors: Alvarez