title: Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling.
abstract: A general method for the facile and versatile decoration of peptides is proposed exploiting furan based cycloaddition and electrophilic aromatic substitution reactions. Given the commercial availability of furylalanine derivatives for peptide synthesis, the current work significantly enlarges the toolbox of available methodologies for site specific labeling and conjugation of peptide probes.
authors: Organic and Biomimetic Chemistry Research Group, Krijgslaan 281, S4, B-9000 Gent, Belgium.
authors: Kurt
authors: K
authors: Hoogewijs
authors: Dieter
authors: D
authors: Buyst
authors: Johan M
authors: JM
authors: Winne
authors: José C
authors: JC
authors: Martins
authors: Annemieke
authors: A
authors: Madder
mesh_terms: D000595:Amino Acid Sequence; D005663:Furans / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D013194:Staining and Labeling
chemical_list: D005663:Furans; D009842:Oligopeptides