title: Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy.
abstract: Photofrin® (porfimer sodium) is a photosensitive reagent used for photodynamic therapy (PDT) of tumors and dysplasias. Because only photo-irradiated sites are damaged, PDT is less invasive than systemic treatments. However, a photosensitive reaction is a major side effect of systemically delivered Photofrin. To enhance localization of Photofrin to tumors, we have formulated Photofrin with the tumor-localizing graft copolymer poly(ethylene glycol)-grafted poly(l-lysine), PLL-g-PEG. We demonstrate that Photofrin preferentially interacts with PLL-g-PEG through both ionic and hydrophobic interactions. The serum competitive study showed that the highly PEG-grafted PLL is better for preventing serum binding to the Photofrin/PLL-g-PEG complex. In tumor-bearing mice, formulation of Photofrin with PLL-g-PEG enhanced tumor localization of Photofrin as twice as Photofrin alone and concomitantly suppressed the photosensitivity reaction drastically.
authors: Institute for Materials Chemistry and Engineering, Kyushu University, 744 Nishi-ku, Motooka, Fukuoka 819-0395, Japan. kano@ms.ifoc.kyushu-u.ac.jp
authors: Arihiro
authors: A
authors: Kano
authors: Yuki
authors: Y
authors: Taniwaki
authors: Izumi
authors: I
authors: Nakamura
authors: Naohiko
authors: N
authors: Shimada
authors: Kenji
authors: K
authors: Moriyama
authors: Atsushi
authors: A
authors: Maruyama
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D001798:Blood Proteins / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D017323:Dihematoporphyrin Ether / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008027:Light; D008099:Liver / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000378:metabolism*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D011092:Polyethylene Glycols / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000737:chemistry; D011485:Protein Binding
chemical_list: D000970:Antineoplastic Agents; D001798:Blood Proteins; D017319:Photosensitizing Agents; C443714:polylysine-graft-(poly(ethylene glycol)); D011107:Polylysine; D011092:Polyethylene Glycols; D017323:Dihematoporphyrin Ether