title: Hepatitis during respiratory syncytial virus infection--a case report.
abstract: BACKGROUND
  Respiratory syncytial virus (RSV) infection is the most common cause of hospitalization in infants and small children. The aim was to present a 13-months old boy diagnosed with acute airway infection, acute otitis media (AOM) and hepatitis during the RSV-infection.
  
  
  METHODS
  Serum catalytic activities of alkaline phosphatase (ALP), aspartate aminotranspherase (AST), alanine aminotranspherase (ALT), gamma glutamyl transpherase (GGT), lactate dehydrogenase (LD), and concentrations of bilirubin were monitored during hospitalization and at control examination.
  
  
  RESULTS
  The child had clinical signs and symptoms of respiratory failure, AOM, and laboratory findings of virus infection and liver disease. On admission, catalytic activities of enzymes were markedly increased, especially the activity of ALP (10333 U/L, i.e. 24-fold increase in comparison with the upper reference limit). The highest increased in AST (339 U/L, 4.5-fold), ALT (475 U/L, 10.3-fold) and LD (545 U/L, 1.5-fold) were registered on the 3rd day, and the highest increase in GGT (68 U/L, 3.1-fold) occurred on the 11th day. Seven weeks after discharge AST, ALT, GGT and LD decreased into reference range, and ALP remain mildly increased (478 U/L, 1.1 fold increase). RSV was confirmed in nasal lavage fluid.
  
  
  CONCLUSIONS
  Laboratory results in patient with RSV infection needs to be interpreted in the light of both, respiratory and extrapulmonary manifestations of the infection, respectively.
authors: Daily Hospital, Srebrnjak Children's Hospital, Zagreb, Croatia.
authors: Branka Kristić
authors: BK
authors: Kirin
authors: Renata Zrinski
authors: RZ
authors: Topić
authors: Slavica
authors: S
authors: Dodig
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D006505:Hepatitis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007223:Infant; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D010033:Otitis Media / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D011379:Prognosis; D018357:Respiratory Syncytial Virus Infections / Q000150:complications* / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000472:pathogenicity*
chemical_list: D015415:Biomarkers; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase