title: Maternal thyroid parameters, body mass index and subsequent weight gain during pregnancy in healthy euthyroid women.
abstract: BACKGROUND
  Obesity and too much weight gain during gestation have a negative effect on obstetric and neonatal outcomes.
  
  
  OBJECTIVE
  To determine the relationship between thyroid hormone parameters, body mass index (BMI) and weight gain during gestation.
  
  
  METHODS
  Prospective follow-up study of thyroid parameters and gestational weight gain.
  
  
  METHODS
  Healthy pregnant women, included at first antenatal consultation.
  
  
  METHODS
  Thyroid function (TSH, FT4 and TPO-Ab) was assessed at 12, 24 and 36 weeks' gestation in 1035 Dutch Caucasian women who delivered at ≥37 weeks. BMI (WHO criteria) was assessed at eight weeks, and weight gain throughout gestation was also assessed using the US Institute of Medicine (IOM) criteria.
  
  
  METHODS
  
  
  
  METHODS
  a possible relationship between maternal thyroid parameters and BMI at the first trimester.
  
  
  METHODS
  the relationship between thyroid parameters and weight gain throughout gestation.
  
  
  RESULTS
  At 12 weeks' gestation, BMI correlated with FT4 (r = -0·14, P < 0·001), but not with TSH (r = 0·04, P = 0·89). 415 (40%) of the women met the IOM criteria for appropriate weight gain, 326 (32%) showed less weight gain and 294 (28%) gained too much weight. At all trimesters, the latter group of women showed higher median TSH and lower median FT4 compared with those with normal weight gain. FT4 at 24 weeks' gestation (OR: 0·84, 95% CI: 0·77-0·91), younger age (OR: 0·97, 95% CI: 0·95-0·99) and primiparity (OR: 0·51, 95% CI: 0·38-0·68) were independently related to too much weight gain.
  
  
  CONCLUSIONS
  Maternal thyroid parameters are related to both prepregnancy BMI and weight gain throughout gestation.
authors: Department of Medical Health Psychology, University of Tilburg, Tilburg, the Netherlands. v.j.m.pop@uvt.nl
authors: Victor J
authors: VJ
authors: Pop
authors: Bernadette
authors: B
authors: Biondi
authors: Hennie A
authors: HA
authors: Wijnen
authors: Simone M
authors: SM
authors: Kuppens
authors: Huib
authors: H
authors: Lvader
mesh_terms: D000328:Adult; D000367:Age Factors; D001323:Autoantibodies / Q000097:blood; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D016015:Logistic Models; D009426:Netherlands; D009765:Obesity / Q000097:blood / Q000208:ethnology / Q000503:physiopathology*; D010298:Parity; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000208:ethnology / Q000503:physiopathology*; D011261:Pregnancy Trimester, First; D011264:Pregnancy Trimesters; D011446:Prospective Studies; D013961:Thyroid Gland / Q000378:metabolism / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D015430:Weight Gain / Q000208:ethnology / Q000502:physiology*; D044465:White People
chemical_list: D001323:Autoantibodies; D013972:Thyrotropin; D007453:Iodide Peroxidase; D013974:Thyroxine