title: Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza.
abstract: The safety and efficacy of an inactivated oil-emulsion infectious coryza vaccine containing three Avibacterium paragallinarum isolates (one each of Page serovars A, B, and C) was evaluated. The safety of six batches of the vaccine was confirmed by testing with chickens vaccinated with a single large dose or vaccinated repeatedly with a normal dose. Efficacy tests were carried out on three batches of vaccine using both specific pathogen free (SPF) chickens and conventional chickens. In SPF chickens given a single vaccination at 42 days of age, the protection rate against all three serovars of Av. paragallinarum was at least 80% at 30 days post vaccination. The conventional chickens, which were immunized at 42 and 110 days of age, were challenged at 9 months post the second vaccination and the protection rate was at least 80% for all three serovars. The effect of storage on the vaccine was evaluated in SPF chickens using three batches of vaccine stored at 4-8°C for 1 year. The protection rate against challenge from all three serovars (single vaccination at 42 days of age and challenge at 30 days post-vaccination) was at least 80%.
authors: Institute of Animal Husbandry and Veterinary Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100097, People's Republic of China.
authors: Yumei
authors: Y
authors: Gong
authors: Institute of Animal Husbandry and Veterinary Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100097, People's Republic of China.
authors: Peijun
authors: P
authors: Zhang
authors: Institute of Animal Husbandry and Veterinary Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100097, People's Republic of China.
authors: Hongjun
authors: H
authors: Wang
authors: Beijing Sinder Vet-Technology Co. Ltd., Shunyi, Beijing 101302, People's Republic of China.
authors: Wenge
authors: W
authors: Zhu
authors: Institute of Animal Husbandry and Veterinary Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100097, People's Republic of China.
authors: Huiling
authors: H
authors: Sun
authors: Institute of Animal Husbandry and Veterinary Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100097, People's Republic of China.
authors: Yunxia
authors: Y
authors: He
authors: Beijing Sinder Vet-Technology Co. Ltd., Shunyi, Beijing 101302, People's Republic of China.
authors: Qinghong
authors: Q
authors: Shao
authors: Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, EcoSciences Precinct, Dutton Park 4001, Brisbane, Australia. Electronic address: p.blackall@uq.edu.au.
authors: P J
authors: PJ
authors: Blackall
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000494:pharmacology*; D002645:Chickens; D006190:Haemophilus / Q000276:immunology*; D006192:Haemophilus Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D007114:Immunization / Q000592:standards / Q000662:veterinary; D011201:Poultry Diseases / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D011897:Random Allocation; D012140:Respiratory Tract Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated
keywords: Infectious Coryza; Potency test; Safety test; Trivalent inactivated vaccine