title: Protective effect of mango (Mangifera indica L.) against UVB-induced skin aging in hairless mice.
abstract: BACKGROUND
  Mangifera indica L. (Anacardiaceae) is a medicinal plant whose extracts have been described as an antioxidant with anti-inflammatory and immunomodulatory activities.
  
  
  OBJECTIVE
  Skin aging is a consequence of chronic sun exposure to the sun and therefore ultraviolet (UV) radiation. Naturally occurring antioxidants are known to reduce skin aging. Therefore, the aim of the present study was to evaluate the protective role of mango extract against UVB-induced skin aging in hairless mice.
  
  
  METHODS
  HR-1 hairless male mice (6 weeks old) were divided into three groups: control (n = 5), UVB-treated vehicle (n = 5), and UVB-treated mango extract (n = 5) groups. UVB-irradiated mice from the mango extract group were orally administered 0.1 ml of water containing 100 mg of mango extract/kg body weight per day. The inhibitory activity of mango extract on wrinkle formation was determined by the analysis of the skin replica, epidermal thickness based on histological examination, and damage to collagen fiber.
  
  
  RESULTS
  The mean length of wrinkles in UVB-treated vehicle group significantly improved after the oral administration of mango extract, which significantly inhibited the increase in epidermal thickness and epidermal hypertrophy (P < 0.05). Furthermore, a marked increase in collagen bundles was observed in the UVB-treated group after the administration of mango extract by Masson's trichrome staining.
  
  
  CONCLUSIONS
  These results indicate that mango extract showed anti-photoaging activity in UVB-irradiated hairless mice.
authors: Aging Research Laboratory, Korea Institute of Oriental Medicine, Daejeon, Korea.
authors: Jae Hyoung
authors: JH
authors: Song
authors: Eun Young
authors: EY
authors: Bae
authors: Goya
authors: G
authors: Choi
authors: Jin Won
authors: JW
authors: Hyun
authors: Mi Young
authors: MY
authors: Lee
authors: Hye Won
authors: HW
authors: Lee
authors: Sungwook
authors: S
authors: Chae
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003094:Collagen / Q000648:ultrastructure; D005638:Fruit; D008297:Male; D031022:Mangifera; D051379:Mice; D008812:Mice, Hairless; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects; D044004:Xanthones / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D010936:Plant Extracts; D044004:Xanthones; C013592:mangiferin; D003094:Collagen