title: Intravitreal ranibizumab as salvage therapy in an extremely low-birth-weight infant with rush type retinopathy of prematurity.
abstract: We report the effects of intravitreal ranibizumab as salvage therapy in an extremely low-birth-weight (ELBW) infant with rush type retinopathy of prematurity (ROP). This case was a girl of 23 weeks gestational age weighing 480 g at birth. At a postconceptual age of 33 weeks, she presented with zone 1, stage 3 ROP with plus disease. Despite intravitreal bevazucimab and laser photocoagulation, extraretinal fibrovascular proliferation persisted. Intravitreal 0.25 mg (0.025 ml) ranibizumab was injected OU. After treatment, extraretinal fibrovascular proliferation disappeared. Fundus examination showed flat retinas and normal vasculature in both eyes. She has been followed up for 2 years. Intravitreal ranibizumab injection seems effective and well tolerated as salvage therapy in an ELBW infant with rush type ROP. No short-term ocular or systemic side effects were identified. More cases and longer follow-up are mandatory.
authors: Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan ; School of Medicine, Chung Shan Medical University, Taichung, Taiwan ; Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan.
authors: Chun-Ju
authors: CJ
authors: Lin
authors: San-Ni
authors: SN
authors: Chen
authors: Jiunn-Feng
authors: JF
authors: Hwang
keywords: Extremely low-birth-weight; intravitreal ranibizumab; rush type retinopathy of prematurity