title: Relationships between adiponectin, sex hormone binding globulin and insulin resistance in hyperthyroid Graves' disease women.
abstract: BACKGROUND
  Adiponectin and sex hormone binding globulin (SHBG) play a role in glucose metabolism. Hyperthyroidism has an impact on carbohydrate metabolism and could affect insulin resistance. The aim of this study was to assess the associations between insulin resistance, adiponectin and SHBG among hyperthyroid Graves` disease (GD) women.
  
  
  METHODS
  The study was undertaken in 60 women with hyperthyroidism in the course of GD; 32 healthy women matched by BMI and age formed the control group. The concentrations of: free thyroxine (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone (TSH), SHBG, insulin, adiponectin and glucose were measured, and the homeostasis model assessment (HOMA-I) was calculated.
  
  
  RESULTS
  Compared to euthyroid subjects, hyperthyroid GD women had elevated glucose, fT4, fT3, adiponectin and SHBG concentrations, but there were no differences in HOMA-I. When we explored the relations between adiponectin as well as SHBG with glucose and HOMA-I, we observed that HOMA-I was associated with adiponectin and SHBG only in the control group, and in hyperthyroidism there were no such connections. We found positive associations between adiponectin, SHBG, fT4 and fT3 in the GD group.
  
  
  CONCLUSIONS
  Elevated concentrations of adiponectin and SHBG were observed in hyperthyroidism but they were not related to insulin resistance.
authors: Department of Pathophysiology and Endocrinology, Medical University of Silesia, Zabrze,pl. Traugutta 2, Poland. lusiem@poczta.onet.pl
authors: Lucyna
authors: L
authors: Siemińska
authors: Wanda
authors: W
authors: Foltyn
authors: Joanna
authors: J
authors: Głogowska-Szeląg
authors: Dariusz
authors: D
authors: Kajdaniuk
authors: Bogdan
authors: B
authors: Marek
authors: Mariusz
authors: M
authors: Nowak
authors: Krzysztof
authors: K
authors: Walczak
authors: Beata
authors: B
authors: Kos-Kudła
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D005260:Female; D006111:Graves Disease / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D052242:Adiponectin; D012738:Sex Hormone-Binding Globulin; D014284:Triiodothyronine; D013974:Thyroxine