title: Impaired lung function is associated with increased carotid intima-media thickness in middle-aged and elderly Chinese.
abstract: BACKGROUND
  Impairment of lung function was reported to be associated with cardiovascular disease (CVD). The aim of the present study is to evaluate the relationship between lung function and carotid intima-media thickness (cIMT) in participants without chronic pulmonary disease.
  
  
  RESULTS
  A total of 6,423 participants aged 40 years and above were recruited from Jiading District, Shanghai, China. Lung function, evaluated by forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) was measured with standard spirometry. CIMT was measured with high-resolution ultrasonography by trained physicians. Mean values of FVC (% pred) and FEV1 (% pred) in participants with elevated cIMT were significantly lower than in those without (0.92±0.20 vs. 0.99±0.19, 0.83±0.24 vs. 0.90±0.22; both p-values < 0.0001). The levels of cIMT in the lowest quartile of FVC (% pred) and FEV1 (% pred) were markedly higher than in the second, third and fourth quartile, respectively (p < 0.0001 for all). The lowest quartile of FVC (% pred) and FEV1 (% pred) was associated with increased odds of elevated cIMT, with the fully adjusted odds ratio of 1.34 and 1.41 (95% confidence interval (CI) 1.09-1.65, p  =  0.006, 95% CI 1.15-1.72, p  =  0.0008), respectively.
  
  
  CONCLUSIONS
  Impaired lung function is associated with elevated cIMT in middle-aged and elderly Chinese. These findings suggest the need to screen impairment of lung function in people without respiratory disease for the presence of subclinical atherosclerosis in CVD prevention.
authors: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China.
authors: Zhimin
authors: Z
authors: Ma
authors: Yu
authors: Y
authors: Liu
authors: Yu
authors: Y
authors: Xu
authors: Yun
authors: Y
authors: Huang
authors: Min
authors: M
authors: Xu
authors: Xiaolin
authors: X
authors: Zhu
authors: Huijie
authors: H
authors: Zhang
authors: Baihui
authors: B
authors: Xu
authors: Fei
authors: F
authors: Huang
authors: Zhi
authors: Z
authors: Yang
authors: Xiaoying
authors: X
authors: Li
authors: Weiqing
authors: W
authors: Wang
authors: Yufang
authors: Y
authors: Bi
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications / Q000503:physiopathology; D002339:Carotid Arteries / Q000473:pathology*; D059168:Carotid Intima-Media Thickness; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000502:physiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014797:Vital Capacity