title: Comparison of cone pathologic changes in idiopathic macular telangiectasia types 1 and 2 using adaptive optics scanning laser ophthalmoscopy.
abstract: OBJECTIVE
  To compare pathologic changes in the photoreceptors of eyes with idiopathic macular telangiectasia types 1 and 2 using adaptive optics scanning laser ophthalmoscopy (AO-SLO).
  
  
  METHODS
  Prospective cross-sectional study.
  
  
  METHODS
  Eleven eyes with idiopathic macular telangiectasia type 1, 14 eyes with type 2, and 10 normal eyes underwent a full ophthalmologic examination, spectral-domain optical coherence tomography (SD-OCT), and imaging with an original prototype AO-SLO system. All eyes with idiopathic macular telangiectasia were examined with fluorescein angiography (FA), confocal blue reflectance, and microperimetry.
  
  
  RESULTS
  Compared with normal eyes (29 017 ± 5507 cones/mm(2)), those with idiopathic macular telangiectasia type 1 had significantly lower cone density on the temporal side (18 427 ± 4908 cones/mm(2), P = .010). The FA leakage area (5.90 ± 3.23 mm(2)) was larger than the dark regions (2.45 ± 2.40 mm(2)) on AO-SLO (P = .003)-which were observed only in the FA leakage area. Compared with normal eyes, those with idiopathic macular telangiectasia type 2 had significantly lower cone density in all areas (P < .05 for all). Patchy dark regions were also seen in areas without FA abnormalities in 12 eyes. Higher mean retinal sensitivity correlated with greater mean cone density 0.5 mm from the center of the fovea (type 1: P = .010; type 2: P < .001).
  
  
  CONCLUSIONS
  Idiopathic macular telangiectasia type-specific differences in the distribution of photoreceptor abnormalities were shown in the AO-SLO images. For both idiopathic macular telangiectasia types 1 and 2, visual impairment was associated with cone damage.
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. ohoto@kuhp.kyoto-u.ac.jp
authors: Sotaro
authors: S
authors: Ooto
authors: Masanori
authors: M
authors: Hangai
authors: Kohei
authors: K
authors: Takayama
authors: Naoko
authors: N
authors: Ueda-Arakawa
authors: Akitaka
authors: A
authors: Tsujikawa
authors: Kenji
authors: K
authors: Yamashiro
authors: Akio
authors: A
authors: Oishi
authors: Masaaki
authors: M
authors: Hanebuchi
authors: Nagahisa
authors: N
authors: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D004396:Coloring Agents; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods*; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology; D017949:Retinal Cone Photoreceptor Cells / Q000473:pathology*; D058456:Retinal Telangiectasis / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green