title: A community-driven global reconstruction of human metabolism.
abstract: Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ∼2× more reactions and ∼1.7× more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.
authors: Center for Systems Biology, University of Iceland, Reykjavik, Iceland. ines.thiele@gmail.com
authors: Ines
authors: I
authors: Thiele
authors: Neil
authors: N
authors: Swainston
authors: Ronan M T
authors: RM
authors: Fleming
authors: Andreas
authors: A
authors: Hoppe
authors: Swagatika
authors: S
authors: Sahoo
authors: Maike K
authors: MK
authors: Aurich
authors: Hulda
authors: H
authors: Haraldsdottir
authors: Monica L
authors: ML
authors: Mo
authors: Ottar
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authors: Rolfsson
authors: Miranda D
authors: MD
authors: Stobbe
authors: Stefan G
authors: SG
authors: Thorleifsson
authors: Rasmus
authors: R
authors: Agren
authors: Christian
authors: C
authors: Bölling
authors: Sergio
authors: S
authors: Bordel
authors: Arvind K
authors: AK
authors: Chavali
authors: Paul
authors: P
authors: Dobson
authors: Warwick B
authors: WB
authors: Dunn
authors: Lukas
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authors: Endler
authors: David
authors: D
authors: Hala
authors: Michael
authors: M
authors: Hucka
authors: Duncan
authors: D
authors: Hull
authors: Daniel
authors: D
authors: Jameson
authors: Neema
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authors: Jamshidi
authors: Jon J
authors: JJ
authors: Jonsson
authors: Nick
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authors: Juty
authors: Sarah
authors: S
authors: Keating
authors: Intawat
authors: I
authors: Nookaew
authors: Nicolas
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authors: Le Novère
authors: Naglis
authors: N
authors: Malys
authors: Alexander
authors: A
authors: Mazein
authors: Jason A
authors: JA
authors: Papin
authors: Nathan D
authors: ND
authors: Price
authors: Evgeni
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authors: Selkov
authors: Martin I
authors: MI
authors: Sigurdsson
authors: Evangelos
authors: E
authors: Simeonidis
authors: Nikolaus
authors: N
authors: Sonnenschein
authors: Kieran
authors: K
authors: Smallbone
authors: Anatoly
authors: A
authors: Sorokin
authors: Johannes H G M
authors: JH
authors: van Beek
authors: Dieter
authors: D
authors: Weichart
authors: Igor
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authors: Goryanin
authors: Jens
authors: J
authors: Nielsen
authors: Hans V
authors: HV
authors: Westerhoff
authors: Douglas B
authors: DB
authors: Kell
authors: Pedro
authors: P
authors: Mendes
authors: Bernhard Ø
authors: BØ
authors: Palsson
mesh_terms: D003198:Computer Simulation; D030562:Databases, Protein; D006801:Humans; D055442:Metabolome / Q000502:physiology*; D008954:Models, Biological; D020543:Proteome / Q000378:metabolism*
chemical_list: D020543:Proteome