title: Increased risk of ischemic stroke in cervical cancer patients: a nationwide population-based study.
abstract: BACKGROUND
  Increased risk of ischemic stroke has been validated for several cancers, but limited study evaluated this risk in cervical cancer patients. Our study aimed to evaluate the risk of ischemic stroke in cervical cancer patients.
  
  
  METHODS
  The study analyzed data from the 2003 to 2008 National Health Insurance Research Database (NHIRD) provided by the National Health Research Institutes in Taiwan. Totally, 893 cervical cancer patients after radiotherapy and 1786 appendectomy patients were eligible. The Kaplan-Meier method and the Cox proportional hazards model were used to assess the risk of ischemic stroke.
  
  
  RESULTS
  The 5-year cumulative risk of ischemic stroke was significantly higher for the cervical cancer group than for the control group (7.8% vs 5.1%; p <0.005). The risk of stroke was higher in younger (age <51 years) than in older (age ≥51 years) cervical cancer patients (HR = 2.73, p = 0.04; HR = 1.37, p = 0.07) and in patients with more than two comorbid risk factors (5 years cumulative stroke rate of two comorbidities: 15% compared to no comorbidities: 4%).
  
  
  CONCLUSIONS
  These study demonstrated cervical cancer patients had a higher risk of ischemic stroke than the general population, especially in younger patients. Strategies to reduce this risk should be assessed.
authors: Department of Radiation Oncology, Buddhist Dalin Tzu Chi General Hospital, 2, Ming Sheng Road, Dalin, Chiayi, Taiwan.
authors: Shiang-Jiun
authors: SJ
authors: Tsai
authors: Yung-Sung
authors: YS
authors: Huang
authors: Chien-Hsueh
authors: CH
authors: Tung
authors: Ching-Chih
authors: CC
authors: Lee
authors: Moon-Sing
authors: MS
authors: Lee
authors: Wen-Yen
authors: WY
authors: Chiou
authors: Hon-Yi
authors: HY
authors: Lin
authors: Feng-Chun
authors: FC
authors: Hsu
authors: Chih-Hsin
authors: CH
authors: Tsai
authors: Yu-Chieh
authors: YC
authors: Su
authors: Shih-Kai
authors: SK
authors: Hung
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002545:Brain Ischemia / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000209:etiology*; D013624:Taiwan; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000628:therapy