title: Inflammatory phenotype of the nurse cell harboring Trichinella spp.
abstract: The nurse cell (NC), formed from muscle cells upon infection with the parasitic nematode Trichinella spp. constitutes a confined habitat for muscle larvae of encapsulating species. Signaling pathway-directed analysis of microarray data allowed identification of the stage of NC cell cycle arrest as being of G1-like type, accompanied by cellular senescence. In accord with the specificity of senescent cellular systems, up-regulation of pro-inflammatory molecules was also found within the NC preparations. Potential immune-related activities associated with NCs as inferred from the aforementioned analysis, are reviewed herein. Transcriptional data suggest that the NC which harbors the larvae may exhibit the following immune-related functions: (i) production of complement components, (ii) antigen presentation and phagocytosis, (iii) pro-inflammatory cytokine secretion, (iv) oxidative stress generation and (v) eicosanoid synthesis.
authors: Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland. mada@nencki.gov.pl
authors: Magdalena
authors: M
authors: Dabrowska
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000947:Antigens, Helminth / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism; D015777:Eicosanoids / Q000378:metabolism; D005786:Gene Expression Regulation / Q000276:immunology; D007249:Inflammation / Q000276:immunology*; D007814:Larva; D032342:Muscle Cells / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology; D010587:Phagocytosis; D010641:Phenotype; D016897:Respiratory Burst; D015398:Signal Transduction / Q000276:immunology*; D014234:Trichinella / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology* / Q000469:parasitology
chemical_list: D000947:Antigens, Helminth; D016207:Cytokines; D015777:Eicosanoids