title: Association between a functional variant at PTGS2 gene 3'UTR and its mRNA expression in lymphoblastoid cell lines.
abstract: PTGS2 genetic 3' untranslated region (3'UTR) miRNA binding sites variants are significantly associated with cancer risk; however, the roles of genetic variants in PTGS2 gene 3'UTR and post-transcriptional regulation have not been elucidated. We report that rs689470 and rs5275 in the PTGS2 3'UTR have potential miRNA-binding sites by using bioinformatics analysis. However, only the rs689470 was significantly associated with PTGS2 mRNA expression in lymphoblastoid cell lines (P = 0.026), but not for rs5275 (P = 0.626). rs689470 might be putative variants mediating the post-transcriptional regulation of target PTGS2 gene. Better understanding of how 3'UTR variants regulate PTGS2 activity will pave the way to targeting the PTGS2 pathway in cancer therapy.
authors: Department of School of Public Health, Boston University, 715 Albany Street, Boston, MA 02118, USA.
authors: Xueting
authors: X
authors: Wang
authors: Yunzhao
authors: Y
authors: Zhao
authors: Yanru
authors: Y
authors: Wang
authors: Zexing
authors: Z
authors: Wang
authors: Xiaoxiang
authors: X
authors: Guan
mesh_terms: D020413:3' Untranslated Regions; D001665:Binding Sites; D045744:Cell Line, Tumor; D019295:Computational Biology; D051546:Cyclooxygenase 2 / Q000235:genetics* / Q000378:metabolism; D016208:Databases, Factual; D005260:Female; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D035683:MicroRNAs / Q000378:metabolism; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D020413:3' Untranslated Regions; D035683:MicroRNAs; D012333:RNA, Messenger; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human