title: Naturally occurring autoantibodies interfere with β-amyloid metabolism and improve cognition in a transgenic mouse model of Alzheimer's disease 24 h after single treatment.
abstract: There is evidence that naturally occurring antibodies directed against Aβ (nAbs-Aβ) have a role in Aβ-metabolism and Aβ-clearance. The presence of nAbs-Aβ leads to a reduction in amyloid fibrillation and thus a reduction in their toxicity. We investigated the effects of nAbs-Aβ in respect to oligomerization and used the Tg2576 transgenic mouse model in order to investigate the rapid effect with a single-dose (24 h) on oligomer breakdown and cytokine secretion along with immunohistochemical characterization of synaptic plasticity. nAbs-Aβ were able to reduce toxic oligomer concentration with an increase in Aβ-monomers. Cytokine secretion was significantly reduced. Synaptic plasticity was also improved after administration of nAbs. Finally, single treatment lead to a significant improvement in cognition. This study demonstrates the efficacy of nAbs-Aβ and presents evidence that several hallmarks of the disease are targeted by nAbs-Aβ.
authors: Department of Neurology, Philipps-University Marburg, Marburg, Germany.
authors: D
authors: D
authors: Mengel
authors: S
authors: S
authors: Röskam
authors: F
authors: F
authors: Neff
authors: K
authors: K
authors: Balakrishnan
authors: O
authors: O
authors: Deuster
authors: M
authors: M
authors: Gold
authors: W H
authors: WH
authors: Oertel
authors: M
authors: M
authors: Bacher
authors: J P
authors: JP
authors: Bach
authors: R
authors: R
authors: Dodel
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D030801:Animals, Genetically Modified; D001323:Autoantibodies / Q000378:metabolism / Q000494:pharmacology*; D015153:Blotting, Western / Q000379:methods; D003071:Cognition / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D016229:Amyloid beta-Peptides; D001323:Autoantibodies; D016207:Cytokines