title: Synergistic influence of age and serum uric acid on blood pressure among community-dwelling Japanese women.
abstract: Serum uric acid (SUA) levels are strongly correlated with aging, gender, renal function, obesity, and metabolic abnormality; however, whether SUA has a causative role in elevated blood pressure (BP) is still a matter of debate. From a single community, we recruited 1177 eligible women (mean age, 61±13 years) during their annual health examination. All subjects were divided into two groups according to their age (participants aged ≥55 years and those aged <55 years). We investigated whether age and SUA are synergistically associated with BP, independent of confounding factors. Of these subjects, SUA significantly correlated with both systolic BP (SBP; r=0.236, P<0.001) and diastolic BP (DBP; r=0.263, P<0.001) in female participants aged <55 years but not in those aged ≥55 years. The interaction between age and SUA on BP as well as age and body mass index, triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, prevalence of antidiabetic medication and SUA was a significant and independent determinant of both SBP (β=-0.106, P=0.011) and DBP (β=-0.070, P=0.003). In participants aged <55 years, the multivariate-adjusted odds ratio (95% confidence interval) for hypertension was 3.03 (1.13-8.11) for the highest tertile (4.8-10.8 mg dl(-1)) of SUA compared with the lowest tertile (0.7-3.8 mg dl(-1)) but was not significant in those aged ≥55 years. These results suggested that age and SUA have a synergistic effect on BP status in community-dwelling women, independent of conventional cardiovascular risk factors.
authors: Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. rykawamo@m.ehime-u.ac.jp
authors: Ryuichi
authors: R
authors: Kawamoto
authors: Yasuharu
authors: Y
authors: Tabara
authors: Katsuhiko
authors: K
authors: Kohara
authors: Tomo
authors: T
authors: Kusunoki
authors: Masanori
authors: M
authors: Abe
authors: Tetsuro
authors: T
authors: Miki
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D002097:C-Reactive Protein