title: Genotype and fetal size affect maternal-fetal amino acid status and fetal endocrinology in Large White × Landrace and Meishan pigs.
abstract: This study compared maternal plasma amino acid concentrations, placental protein secretion in vitro and fetal body composition and plasma amino acid and hormone concentrations in feto-placental units from the smallest and a normally-sized fetus carried by Large White × Landrace or Meishan gilts on Day 100 of pregnancy. Compared with Large White × Landrace, Meishan placental tissue secreted more protein and Meishan fetuses contained relatively more fat and protein, but less moisture. Fetal plasma concentrations of insulin, triiodothryonine, thyroxine and insulin-like growth factor (IGF)-II were higher in Meishan than Large White × Landrace fetuses. In both breeds, fetal cortisol concentrations were inversely related to fetal size, whereas concentrations of IGF-I were higher in average-sized fetuses. Concentrations of 10 amino acids were higher in Large White × Landrace than Meishan gilts, while glutamine concentrations were higher in Meishan gilts. Concentrations of alanine, aspartic acid, glutamic acid and threonine were higher in Meishan than Large White × Landrace fetuses. Average-sized fetuses had higher concentrations of asparagine, leucine, lysine, phenylalanine, threonine, tyrosine and valine than the smallest fetus. This study revealed novel genotype and fetal size differences in porcine maternal-fetal amino acid status and fetal hormone and metabolite concentrations.
authors: The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Scotland, UK. cheryl.ashworth@roslin.ed.ac.uk
authors: Cheryl J
authors: CJ
authors: Ashworth
authors: Margaret O
authors: MO
authors: Nwagwu
authors: Harry J
authors: HJ
authors: McArdle
mesh_terms: D000596:Amino Acids / Q000097:blood*; D000818:Animals; D001947:Breeding / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000662:veterinary; D003433:Crosses, Genetic; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D005333:Fetus / Q000033:anatomy & histology / Q000378:metabolism; D005838:Genotype; D006854:Hydrocortisone / Q000097:blood; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism*; D011863:Radioimmunoassay / Q000662:veterinary; D013045:Species Specificity; D034421:Sus scrofa / Q000235:genetics* / Q000502:physiology
chemical_list: D000596:Amino Acids; D011257:Pregnancy Proteins; D006854:Hydrocortisone