title: Serum adiponectin level is not only decreased in metabolic syndrome but also in borderline metabolic abnormalities.
abstract: OBJECTIVE
  Along with the increasing prevalence of obesity and related diseases, particularly atherosclerotic diseases, metabolic syndrome (MetS) is now a common and major public health issue in many countries around the world. Adiponectin, a protein secreted by the adipose tissue, has become recognized as a key player in the development of MetS. These days, not only MetS but also borderline metabolic/physiological abnormalities, such as impaired fasting glucose, high normal blood pressure and high normal plasma cholesterol, have been reported to be risk factors for atherosclerotic disease. Therefore, we undertook this study to determine the relationship between adiponectin and borderline metabolic/physiological abnormalities, as well as MetS.
  
  
  METHODS
  A cross-sectional study performed from April 2007 to November 2009.
  
  
  METHODS
  In 16 892 Japanese adults (10 008 men and 6884 women), we examined the relationship between the serum adiponectin concentration and borderline metabolic/physiological abnormalities or MetS by a questionnaire survey about medical treatment, body size measurement and measurement of laboratory parameters including the serum adiponectin concentration.
  
  
  RESULTS
  Adiponectin showed a significant negative correlation with the number of MetS components. In subjects without overt diabetes mellitus, hypertension or dyslipidemia, the adiponectin concentration also showed a significant negative correlation with the number of borderline metabolic abnormalities.
  
  
  CONCLUSIONS
  The decrease of circulating adiponectin may start before the development of diabetes mellitus, hypertension, dyslipidemia or MetS. Adiponectin is an important biomarker for reflecting the adverse influence of visceral fat in persons with MetS, and also in these subclinical states.
authors: Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan.
authors: M Y
authors: MY
authors: Baden
authors: Y
authors: Y
authors: Yamada
authors: Y
authors: Y
authors: Obata
authors: Y
authors: Y
authors: Hosakawa
authors: K
authors: K
authors: Saisho
authors: S
authors: S
authors: Tamba
authors: K
authors: K
authors: Yamamoto
authors: M
authors: M
authors: Umeda
authors: A
authors: A
authors: Furubayashi
authors: Y
authors: Y
authors: Tsukamoto
authors: Y
authors: Y
authors: Matsuzawa