title: Anti-inflammatory effects of essential oil in Echinacea purpurea L.
abstract: Echinacea purpurea L. is a medicinal plant originally from North America. It has become a commonly used herbal medicine worldwide because it contains various biologically active compounds. This study was designed to investigate the anti-inflammatory effects of essential oils from E. purpurea in both mice and rats. The extract was obtained from flower of E. purpurea by steam distillation. The anti-inflammatory potential was evaluated in vivo by using different animal models such as xylene-induced mouse ear edema, egg-white-induced rat paw edema, and cotton-induced granuloma tissue proliferating inflammation in mice. The serial dosages were used in vivo: the low dosage, the medium dosage and the high dosage. The low, medium and high dosages of extracts produced inhibitions of 39.24%, 47.22% and 44.79% respectively in the ear edema induced by xylene when compare with the control group. Only the high dosage group showed statistically significant inhibition (48.51%) of paw edema formation induced three hours by egg white compared with the control group (P<0.01). Moreover, the granulation formation was also significantly reduced the most by 28.52% in the high dose groups compared with the control group (P <0.05). The pro-inflammatory cytokines such as IL-2, IL-6 and TNF-α in the blood were reduced in the treated groups. The essential oils from extracts of E. purpurea have anti-inflammatory effects.
authors: College of Life Sciences, Anhui Agricultural University, Botany Laboratory, Anhui, China.
authors: Deqiang
authors: D
authors: Yu
authors: Yi
authors: Y
authors: Yuan
authors: Ling
authors: L
authors: Jiang
authors: Yuling
authors: Y
authors: Tai
authors: Xiumei
authors: X
authors: Yang
authors: Fang
authors: F
authors: Hu
authors: Zhongwen
authors: Z
authors: Xie
mesh_terms: D000418:Albumins; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D032561:Cotton Fiber; D004195:Disease Models, Animal; D057168:Distillation; D004305:Dose-Response Relationship, Drug; D020900:Echinacea / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D004527:Egg Proteins; D035264:Flowers; D015745:Granuloma, Foreign-Body / Q000097:blood / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000378:metabolism; D007376:Interleukin-2 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D008517:Phytotherapy; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014992:Xylenes
chemical_list: D000418:Albumins; D000893:Anti-Inflammatory Agents; D004527:Egg Proteins; D018836:Inflammation Mediators; D007376:Interleukin-2; D015850:Interleukin-6; D009822:Oils, Volatile; D010938:Plant Oils; D014409:Tumor Necrosis Factor-alpha; D014992:Xylenes; D001241:Aspirin