title: IL10 inversely correlates with the percentage of CD8⁺ cells in MDS patients.
abstract: The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS.
authors: Haematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, São Paulo, Brazil.
authors: Matheus Rodrigues
authors: MR
authors: Lopes
authors: Fabiola
authors: F
authors: Traina
authors: Paula de Melo
authors: Pde M
authors: Campos
authors: João Kleber Novais
authors: JK
authors: Pereira
authors: João Agostinho
authors: JA
authors: Machado-Neto
authors: Helymar da Costa
authors: Hda C
authors: Machado
authors: Simone Cristina Olenscki
authors: SC
authors: Gilli
authors: Sara Teresinha Olalla
authors: ST
authors: Saad
authors: Patricia
authors: P
authors: Favaro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D060908:CTLA-4 Antigen / Q000097:blood; D005260:Female; D051858:Forkhead Transcription Factors / Q000097:blood; D005786:Gene Expression Regulation; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000473:pathology; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C508609:IL10 protein, human; D053773:Transforming Growth Factor beta1; D016753:Interleukin-10