title: Biological embedding in mental health: an epigenomic perspective.
abstract: Human epidemiological studies and studies of animal models provide many examples by which early life experiences influence health in a long-term manner, a concept known as biological embedding. Such experiences can have profound impacts during periods of high plasticity in prenatal and early postnatal life. Epigenetic mechanisms influence gene function in the absence of changes in gene sequence. In contrast to the relative stability of gene sequences, epigenetic mechanisms appear, at least to some extent, responsive to environmental signals. To date, a few examples appear to clearly link early social experiences to epigenetic changes in pathways relevant for mental health in adulthood. Our recent work using high-throughput epigenomic techniques points to large-scale changes in gene pathways in addition to candidate genes involved in the response to psychosocial stress and neuroplasticity. Elucidation of which pathways are epigenetically labile under what conditions will enable a more complete understanding of how the epigenome can mediate environmental interactions with the genome that are relevant for mental health. In this mini-review, we provide examples of nascent research into the influence of early life experience on mental health outcomes, discuss evidence of epigenetic mechanisms that may underlie these effects, and describe challenges for research in this area.
authors: Department of Biological Sciences, University of Toronto, Scarborough, Canada.
authors: Aya
authors: A
authors: Sasaki
authors: Wilfred C
authors: WC
authors: de Vega
authors: Patrick O
authors: PO
authors: McGowan
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D057890:Epigenomics; D018507:Gene Expression Regulation, Developmental; D059647:Gene-Environment Interaction; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D008603:Mental Health; D010641:Phenotype; D015398:Signal Transduction; D013315:Stress, Psychological / Q000235:genetics*; D013995:Time