title: Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers.
abstract: OBJECTIVE
  To identify characteristics of exercise-induced collapse in Labrador Retrievers and compare characteristics for dogs with various dynamin 1 gene (DNM1) mutation statuses.
  
  
  METHODS
  Retrospective cross-sectional study.
  
  
  METHODS
  109 Labrador Retrievers with a history of recurrent exercise-induced collapse, clinically normal behavior and gait between episodes, and no reason for collapse identified via medical evaluation.
  
  
  METHODS
  Data were collected via surveys from owners of dogs that were tested for an autosomal recessive DNM1 mutation causing DNM1-associated exercise-induced collapse (d-EIC). Dogs were identified as having d-EIC (homozygous for the mutation) or not having d-EIC (heterozygous for or without the mutation). Survey data were reviewed by an investigator unaware of the genotypes of dogs, and collapse characteristics were compared between groups.
  
  
  RESULTS
  74 dogs had d-EIC; 35 dogs did not have d-EIC. Dogs with d-EIC were young (median age, 12 months) at the time of the first collapse episode; collapse in such dogs typically originated in the hind limbs and was characterized by low muscle tone, clinically normal mentation, and rapid recovery. Dogs without d-EIC were older (median age, 23 months) than dogs with d-EIC; such dogs had various characteristics of collapse that were not consistent with a single disease.
  
  
  CONCLUSIONS
  Characteristics of exercised-induced collapse in Labrador Retrievers with various DNM1 genotypes were identified in this study; findings may help distinguish dogs with d-EIC from those with other types of collapse conditions. Characteristics of collapse in Labrador Retrievers that were not homozygous for the DNM1 mutation differed substantially among dogs and may have been attributable to multiple causes.
authors: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA. furro004@umn.edu
authors: Eva
authors: E
authors: Furrow
authors: Katie M
authors: KM
authors: Minor
authors: Susan M
authors: SM
authors: Taylor
authors: James R
authors: JR
authors: Mickelson
authors: Edward E
authors: EE
authors: Patterson
mesh_terms: D000818:Animals; D003430:Cross-Sectional Studies; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D034284:Dynamin I / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D020022:Genetic Predisposition to Disease; D008297:Male; D009154:Mutation; D010805:Physical Conditioning, Animal / Q000009:adverse effects*; D012680:Sensitivity and Specificity
chemical_list: D034284:Dynamin I