title: Liver involvement in HIV-infected patients with early syphilis.
abstract: The aim of the paper is to analyse the prevalence of liver involvement and related factors in HIV-infected patients with early syphilis (<2 years). Liver involvement was defined as an elevation above normal ranges of alanine transaminase, aspartate aminotransferase, gamma-glutamyltransferase and/or alkaline phosphatase during early syphilis, or doubling of previous levels in patients with liver enzyme elevation before syphilis. We undertook a multicentre study and of the 147 cases, 86.4% were men who had sex with men, and the diagnoses of syphilis and HIV infection were coincident in 48 (32.7%). Liver involvement was detected in 45 (30.6%) and the only related factor was a rapid plasma reagin (RPR) titre ≥1/64 (odds ratio 3.76; 95% confidence interval 1.3-10.5; P = 0.012). In conclusion, liver involvement occurs in around one-third of HIV-infected patients with early syphilis and is associated with high RPR levels. Syphilis should be included in the differential diagnosis of liver enzyme elevation in HIV-infected patients.
authors: UGC de Enfermedades Infecciosas, Hospital Virgen de la Victoria.
authors: R
authors: R
authors: Palacios
authors: F
authors: F
authors: Navarro
authors: D
authors: D
authors: Narankiewicz
authors: M
authors: M
authors: Marcos
authors: F
authors: F
authors: Jiménez-Oñate
authors: J
authors: J
authors: de la Torre
authors: J
authors: J
authors: Santos
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D042241:Early Diagnosis; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D018451:Homosexuality, Male; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000453:epidemiology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013587:Syphilis / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D013588:Syphilis Serodiagnosis
chemical_list: D000469:Alkaline Phosphatase
keywords: HIV; Treponema pallidum; early syphilis; hepatitis; liver enzymes; syphilis