title: Severe hypothalamopituitary dysfunction accompanied by influenza-associated encephalopathy: report of two pediatric cases.
abstract: Severe influenza infection may lead to neurological damage, such as encephalopathy. This may, in turn, cause acquired hypothalamopituitary dysfunction, which can result in severe morbidity and even death. We herein report two pediatric patients who developed influenza-associated hypopituitarism and were subsequently diagnosed with encephalopathy. They were diagnosed with acute necrotizing encephalopathy and postresuscitation encephalopathy, respectively. Both showed evidence of endocrine dysfunction, and hormone replacement therapy of adrenal, thyroid, and antidiuretic hormones are resulting in continued cardiac activity and resulted in prolonged survival. Screening for endocrine function is important in patients with severe central nervous system dysfunction.
authors: Department of Pediatrics, University of Yamanashi, Yamanashi, Japan. yagasaki@mwd.biglobe.ne.jp
authors: Hideaki
authors: H
authors: Yagasaki
authors: Kisho
authors: K
authors: Kobayashi
authors: Tomohiro
authors: T
authors: Saito
authors: Yusuke
authors: Y
authors: Goto
authors: Takayuki
authors: T
authors: Komai
mesh_terms: D001927:Brain Diseases / Q000151:congenital / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007027:Hypothalamic Diseases / Q000151:congenital / Q000000981:diagnostic imaging / Q000209:etiology*; D007030:Hypothalamo-Hypophyseal System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007223:Infant; D007251:Influenza, Human / Q000150:complications* / Q000151:congenital / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed