title: Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India.
abstract: Saliva is a biological fluid that has not been used extensively as a biomonitoring tool in epidemiological studies. This study presents the arsenic (As) concentrations in saliva and urine samples collected from populations of West Bengal, India who had been previously exposed to high As levels in their drinking water. We found a significant (p < 0.05) association between the Log transformed Daily Ingestion of As (μg day(-1)) and the As concentration in saliva (r = 0.68). Additionally, As concentration of saliva and urine also had a significant positive correlation (r = 0.60, p < 0.05). Male participants, smokers, and cases of skin lesion were independently and significantly associated with an increase in salivary As. Thus our findings show that saliva is a useful biomarker of As exposure in the study population. The study also advocates that measurement of the forms of As in saliva may additionally provide insight into the internal dose and any individual differences in susceptibility to As exposure.
authors: Department of Chemistry, University of Kalyani, Nadia 741 235, West Bengal, India.
authors: Subhamoy
authors: S
authors: Bhowmick
authors: Dipti
authors: D
authors: Halder
authors: Amit Kumar
authors: AK
authors: Kundu
authors: Debasree
authors: D
authors: Saha
authors: Mònica
authors: M
authors: Iglesias
authors: Jerome
authors: J
authors: Nriagu
authors: Debendra Nath
authors: DN
authors: Guha Mazumder
authors: Gabriela
authors: G
authors: Roman-Ross
authors: Debashis
authors: D
authors: Chatterjee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001151:Arsenic / Q000378:metabolism* / Q000652:urine; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D060766:Drinking Water / Q000737:chemistry; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011786:Quality Control; D012044:Regression Analysis; D012463:Saliva / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D060766:Drinking Water; D001151:Arsenic