title: Platinum(II) complexes with mono-aminophosphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: synthesis, crystal structure and antitumour activity.
abstract: Six new platinum(II) complexes with mono-aminophosphonate ester were synthesized and characterized by elemental analysis, (1)H NMR, ESI-MS as well as single crystal X-ray diffraction analysis. They are mononuclear structures. In all the crystal structures of complexes 1-6, the platinum centre adopts an approximately square-planar geometry, which were found to possess excellent solubility in both organic solvents and water and exhibit considerable cytotoxicity against MG-63, SK-OV-3 and HepG2 cell lines, but low cytotoxicity towards normal human liver cell HL-7702. In contrast to cisplatin, their antitumour activities are achieved through the induction of cell apoptosis by G1 cell-cycle arrest.
authors: School of Chemistry of Nankai University, Tianjin 300071, PR China.
authors: Ke-Bin
authors: KB
authors: Huang
authors: Zhen-Feng
authors: ZF
authors: Chen
authors: Yan-Cheng
authors: YC
authors: Liu
authors: Zhu-Quan
authors: ZQ
authors: Li
authors: Jian-Hua
authors: JH
authors: Wei
authors: Meng
authors: M
authors: Wang
authors: Guo-Hai
authors: GH
authors: Zhang
authors: Hong
authors: H
authors: Liang
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005434:Flow Cytometry; D059585:G1 Phase Cell Cycle Checkpoints / Q000187:drug effects*; D056945:Hep G2 Cells; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010984:Platinum / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D063065:Organophosphonates; D009944:Organoplatinum Compounds; D010984:Platinum