title: Increased concentrations of soluble CD40 ligand platelet in patients with primary antiphospholipidic syndrome.
abstract: OBJECTIVE
  To determine the concentrations of sCD40L in patients with PAPS, and establish its association with the number of thrombosis.
  
  
  METHODS
  We included patients with PAPS and healthy controls of the same age and sex. For analysis, patients with PAPS were divided into 2 groups: 1) patients with 1 thrombosis, and 2) patients with >1 thrombosis. Soluble CD40L concentrations were determined by ELISA method.
  
  
  RESULTS
  sCD40L concentrations were significantly higher in patients with PAPS compared with the controls (9.72 ng ± 11.23 ng/ml vs. 4.69 ± 4.04 ng/ml) (P=.04) There was no association between serum levels of sCD40L and the number of thrombosis (1 thrombosis: 9.81 ± 9.87 ng/ml vs 9.63 ± 12.75 ng/ml in ≥ 1thrombosis (P=.13). In women with pregnancy and abortions, (13 patients) concentrations of sCD40L were higher than in those patients without a history of abortion (26 patients) but without statically significant difference (12.11 ± 16.46 ng/ml vs. 8.80 ± 8.61 ng/ml) (P=.33). There was no correlation between levels of sCD40L and the total number of thrombosis.
  
  
  CONCLUSIONS
  Patients with PAPS have higher concentrations of sCD40L compared with healthy subjects, although this is not associated with a greater number of thrombosis. Among patients with PAPS, there is a tendency to higher concentrations of sCD40L in women with pregnancy and history of abortion. Since the platelet is the main cellular source of sCD40L, is possible that this pathway plays a pathogenic role in patients with PAPS.
authors: Departamento de Reumatología, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México.
authors: Aida
authors: A
authors: Galicia López
authors: Lourdes
authors: L
authors: Olguín Ortega
authors: Miguel A
authors: MA
authors: Saavedra
authors: René
authors: R
authors: Méndez Cruz
authors: Rafael
authors: R
authors: Jimenez Flores
authors: Maximiliano
authors: M
authors: García de la Peña
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood* / Q000150:complications; D001792:Blood Platelets; D023201:CD40 Ligand / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D013927:Thrombosis / Q000097:blood / Q000453:epidemiology / Q000209:etiology
chemical_list: D023201:CD40 Ligand
keywords: Activación plaquetaria; Anticuerpos antifosfolipídicos; Antiphospholipids antibodies; Aterosclerosis; Atherosclerosis; Ligando CD40 soluble; Platelet activation; Soluble CD40 ligand; Thrombosis; Trombosis