title: [Expression of CCAAT/enhancer binding protein beta in human gastric carcinoma and its clinical significance].
abstract: OBJECTIVE
  To explore the expression of CCAAT/enhancer binding protein beta (CEBPB) in gastric carcinoma tissues and its association with clinicopathological features and prognosis.
  
  
  METHODS
  CEBPB protein expression level was detected by immunohistochemistry method in resected gastric carcinomas and adjacent gastric mucosa tissues (n=81), and its association with clinicopathological features and prognosis was analyzed.
  
  
  RESULTS
  The immunohistochemical staining of CEBPB was predominantly in the nucleus with some cytoplasmic staining. As a result, 16% (13/81) of the gastric carcinomas were stained positively, whereas there was hardly positive expression in adjacent gastric mucosa tissues. There was a significant association between the expression of CEBPB and distant metastasis on univariate analysis (P<0.05). The median survival time in patients with positive CEBPB expression was significantly lower than those with negative CEBPB expression (19.4 months vs. 45.2 months, P=0.024). Multivariable analysis showed that CEBPB was independently associated with prognosis (HR=2.544, 95%CI:1.154-5.610, P=0.021).
  
  
  CONCLUSIONS
  Up-regulation of CEBPB suggests poor prognosis in patients with gastric cancer.
authors: Department of Gastrointestinal Cancer Surgery, Peking Cancer Hospital and Institute, Peking University Cancer Hospital, Beijing 100142, China.
authors: Yun-xia
authors: YX
authors: Du
authors: Lian-hai
authors: LH
authors: Zhang
authors: Xiao-hong
authors: XH
authors: Wang
authors: Xiao-fang
authors: XF
authors: Xing
authors: Xiao-jing
authors: XJ
authors: Cheng
authors: Hong
authors: H
authors: Du
authors: Ying
authors: Y
authors: Hu
authors: Ying-ai
authors: YA
authors: Li
authors: Yu-bing
authors: YB
authors: Zhu
authors: Yong-ning
authors: YN
authors: Jia
authors: Yi
authors: Y
authors: Lin
authors: Jia-fu
authors: JF
authors: Ji
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D022782:CCAAT-Enhancer-Binding Protein-beta; C545012:CEBPB protein, human