title: [Complications after lung transplantation in chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  Lung transplantation (LT) in chronic obstructive pulmonary disease (COPD) is a procedure with a high rate of morbimortality. The aim of this paper is to analyze the early and late rates of complications and mortality in COPD patients undergoing LT.
  
  
  METHODS
  Retrospective study of 107 COPD patients transplanted in the Hospital Universitario La Fe, between 1991 and 2008. Preoperative variables were collected as well as all the complications, medical and surgical, occurred in the follow-up, which are expressed as mean or percentage as appropriate. The 30-day mortality and long term survival were established.
  
  
  RESULTS
  A total of 94 men (87.9%) and 13 women (12.1%) were transplanted with a mean age (SD) of 52.58 (8.05) years with 71% of double-lung LT. BODE score was 7.24 (1.28). The rate of primary graft dysfunction was 39.3%. The most common surgical complications were phrenic paralysis (16.8%), hemothorax (17.8%) and pleural effusion (30.8%). There was a high number of postoperative hospitalization (30%) and medical complications such as hypertension (36%), diabetes mellitus (16.7%) and renal failure (40%), secondary to treatment. Perioperative mortality was 14% and 34.5% after a year, being the most frequent causes infections (34.6%) and chronic rejection (BOS) (17.8%). Five-year survival was 40.9% with bronchiectasis and smoking history being the risk factors.
  
  
  CONCLUSIONS
  LT is a procedure with a high early mortality rate associated with high medical and surgical complications that affect the outcome.
authors: Servicio de Cirugía Torácica, Hospital Clínico Universitario, Valencia, España. ceronjs@yahoo.es
authors: José
authors: J
authors: Cerón Navarro
authors: Karol
authors: K
authors: de Aguiar Quevedo
authors: Nuria
authors: N
authors: Mancheño Franch
authors: Juan Carlos
authors: JC
authors: Peñalver Cuesta
authors: Francisco José
authors: FJ
authors: Vera Sempere
authors: José
authors: J
authors: Padilla Alarcón
mesh_terms: D015897:Comorbidity; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006491:Hemothorax / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010791:Phrenic Nerve / Q000293:injuries; D010996:Pleural Effusion / Q000453:epidemiology / Q000209:etiology; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D019106:Postoperative Hemorrhage / Q000453:epidemiology / Q000209:etiology; D055031:Primary Graft Dysfunction / Q000453:epidemiology; D016016:Proportional Hazards Models; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery*; D012129:Respiratory Function Tests; D012133:Respiratory Paralysis / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects; D013030:Spain / Q000453:epidemiology; D015996:Survival Rate
chemical_list: D007166:Immunosuppressive Agents