title: Selective access to trisubstituted macrocyclic E- and Z-alkenes from the ring-closing metathesis of vinylsiloxanes.
abstract: Macrocyclic (E)-alkenylsiloxanes, obtained from E-selective ring-closing metathesis reactions, can be converted to the corresponding (Z)-alkenyl bromides and (E)-alkenyl iodides allowing access to both E- and Z-trisubstituted macrocyclic alkenes. The reaction conditions and substrate scope of these stereoselective transformations are explored.
authors: Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
authors: Yikai
authors: Y
authors: Wang
authors: Miguel
authors: M
authors: Jimenez
authors: Patrick
authors: P
authors: Sheehan
authors: Cheng
authors: C
authors: Zhong
authors: Alvin W
authors: AW
authors: Hung
authors: Chun Pong
authors: CP
authors: Tam
authors: Damian W
authors: DW
authors: Young
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012833:Siloxanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D006846:Hydrocarbons, Halogenated; D012833:Siloxanes