title: Cyclophilins in atherosclerosis: a new therapeutic target?
abstract: Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible approaches to selectively target this novel proinflammatory factor.
authors: GWU SMHS, 2300 Eye St. NW, Ross Hall Rm. 736, Washington, DC 20037. mbukrins@gwu.edu.
authors: Michael
authors: M
authors: Bukrinsky
authors: Alexander
authors: A
authors: Orekhov
authors: Michael
authors: M
authors: Ditiatkovski
authors: Dmitri
authors: D
authors: Sviridov
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000201:enzymology* / Q000276:immunology; D051926:Basigin / Q000276:immunology; D002630:Chemotactic Factors / Q000276:immunology*; D021983:Cyclophilins / Q000037:antagonists & inhibitors / Q000276:immunology*; D003524:Cyclosporins / Q000494:pharmacology / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000276:immunology; D058990:Molecular Targeted Therapy
chemical_list: D002630:Chemotactic Factors; D003524:Cyclosporins; D051926:Basigin; D020782:Matrix Metalloproteinases; D021983:Cyclophilins