title: Impaired vitamin D metabolism in CKD.
abstract: Vitamin D metabolism consists of both production and catabolism, which are enzymatically driven and highly regulated. Renal vitamin D metabolism requires filtration and tubular reabsorption of 25-hydroxyvitamin D and is regulated by parathyroid hormone, fibroblast growth factor-23, and 1,25-dihydroxyvitamin D. In chronic kidney disease, renal production of 1,25-dihydroxyvitamin D from 25-hydroxyvitamin D is reduced. In addition, pharmacokinetic studies and epidemiologic studies of 24,25-dihydroxyvitamin D, the most abundant product of 25-hydroxyvitamin D catabolism by CYP24A1, suggest that vitamin D catabolism also is reduced. New insights into the mechanisms and regulation of vitamin D metabolism may lead to novel approaches to assess and treat impaired vitamin D metabolism in chronic kidney disease.
authors: Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA, USA.
authors: Cortney
authors: C
authors: Bosworth
authors: Ian H
authors: IH
authors: de Boer
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D005966:Glucuronidase / Q000502:physiology; D006801:Humans; D000090265:Klotho Proteins; D010281:Parathyroid Hormone / Q000502:physiology; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000378:metabolism*
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D005346:Fibroblast Growth Factors; C097949:1,25-dihydroxyvitamin D; D000089703:Fibroblast Growth Factor-23; D003577:Cytochrome P-450 Enzyme System; D005966:Glucuronidase; D000090265:Klotho Proteins