title: The modification of microstructure to improve the biodegradation and mechanical properties of a biodegradable Mg alloy.
abstract: The effect of microstructural modification on the degradation behavior and mechanical properties of Mg-5wt%Ca alloy was investigated to tailor the load bearing orthopedic biodegradable implant material. The eutectic Mg/Mg2Ca phase precipitated in the as-cast Mg-5wt%Ca alloy generated a well-connected network of Mg2Ca, which caused drastic corrosion due to a micro galvanic cell formed by its low corrosion potential. Breaking the network structure using an extrusion process remarkably retarded the degradation rate of the extruded Mg-5wt%Ca alloy, which demonstrates that the biocompatibility and mechanical properties of Mg alloys can be enhanced through modification of their microstructure. The results from the in vitro and in vivo study suggest that the tailored microstructure by extrusion impede the deterioration in strength that arises due to the dynamic degradation behavior in body solution.
authors: Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650, South Korea.
authors: Hyung-Seop
authors: HS
authors: Han
authors: Yin
authors: Y
authors: Minghui
authors: Hyun-Kwang
authors: HK
authors: Seok
authors: Ji-Young
authors: JY
authors: Byun
authors: Pil-Ryung
authors: PR
authors: Cha
authors: Seok-Jo
authors: SJ
authors: Yang
authors: Yu Chan
authors: YC
authors: Kim
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000633:toxicity*; D002118:Calcium / Q000737:chemistry* / Q000633:toxicity*; D019245:Compressive Strength; D055119:Elastic Modulus; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008274:Magnesium / Q000737:chemistry* / Q000633:toxicity*; D008297:Male; D008422:Materials Testing; D051381:Rats; D017207:Rats, Sprague-Dawley; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D008274:Magnesium; D002118:Calcium