title: Predicting lead relative bioavailability in peri-urban contaminated soils using in vitro bioaccessibility assays.
abstract: In this study, lead (Pb) bioaccessibility was assessed in peri-urban contaminated soils using a variety of established in vitro assays. Bioaccessibility data was then used to predict Pb relative bioavailability (RBA) using published in vivo-in vitro regression models in order to compare calculated estimates and measured values. Lead bioaccessibility varied depending on the in vitro methodology employed with the relative bioavailability leaching procedure (RBALP) and in vitro gastrointestinal (IVG) assays providing more conservative Pb bioaccessibility values compared to those determined using PBET, UBM and Rel-SBRC-I assays. When Pb RBA was calculated, predicted values using PBET-G and UBM-G data were similar to measured Pb RBA values. However, Pb RBA was over-estimated by 1.6-5.5- and 2.6-6.6-fold when data and regression models from RBALP and IVG-G assays were employed.
authors: Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes Campus, Adelaide, South Australia, Australia. Albert.Juhasz@unisa.edu.au
authors: Albert L
authors: AL
authors: Juhasz
authors: Euan
authors: E
authors: Smith
authors: John
authors: J
authors: Weber
authors: Matthew
authors: M
authors: Rees
authors: Tim
authors: T
authors: Kuchel
authors: Allan
authors: A
authors: Rofe
authors: Lloyd
authors: L
authors: Sansom
authors: Ravi
authors: R
authors: Naidu
mesh_terms: D000818:Animals; D001682:Biological Availability; D004784:Environmental Monitoring / Q000379:methods* / Q000706:statistics & numerical data; D005544:Forecasting; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D017745:Incineration; D007413:Intestinal Mucosa / Q000378:metabolism; D007854:Lead / Q000032:analysis* / Q000493:pharmacokinetics*; D016014:Linear Models; D008954:Models, Biological; D012037:Refuse Disposal; D012989:Soil Pollutants / Q000032:analysis* / Q000493:pharmacokinetics*; D013552:Swine; D014506:Urban Renewal
chemical_list: D012989:Soil Pollutants; D007854:Lead