title: Relationship of PGC-1α gene polymorphism with insulin resistance syndrome in Korean children.
abstract: This study aimed to investigate the associations between peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) gene Gly482Ser polymorphism (rs8192678) and parameters of insulin resistance in a sample of Korean children. A total of 286 children aged 10 to 12 years old were recruited from local elementary schools. Measured variables included body fat, blood pressures, blood lipids, glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and accelerometer-based physical activity (PA). Significant differences in percentage body fat (P = .016), insulin (P = .013), and HOMA-IR (P = .007) were found according to Gly482Ser genotype, with no significant genotype differences in the other measured variables. The genotype-specific differences in insulin (P = .136) and HOMA-IR (P = .067) were significantly attenuated when adjusted for age, sex, Tanner stage, body fat, and PA. The findings of the study suggest that the genetic effects of the PGC-1α genotypes on parameters of insulin resistance might be modulated by lifestyle factors, including PA and body fatness.
authors: Sungkyunkwan University, Suwon, Republic of Korea.
authors: Chang-Duk
authors: CD
authors: Ha
authors: Sungkyunkwan University, Suwon, Republic of Korea.
authors: Jin-Kyung
authors: JK
authors: Cho
authors: Sungkyunkwan University, Suwon, Republic of Korea.
authors: Taekyung
authors: T
authors: Han
authors: Pohang University of Science and Technology, Pohang, Republic of Korea.
authors: Shin-Ho
authors: SH
authors: Lee
authors: Sungkyunkwan University, Suwon, Republic of Korea hkang@skku.edu.
authors: Hyun-Sik
authors: HS
authors: Kang
mesh_terms: D050154:Adiposity; D001786:Blood Glucose; D001794:Blood Pressure; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D011110:Polymorphism, Genetic; D056910:Republic of Korea / Q000453:epidemiology; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D008055:Lipids; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors
keywords: PGC-1α gene; body fatness; children; insulin resistance; physical activity