title: Towards improved receptor targeting: anterograde transport, internalization and postendocytic trafficking of neuropeptide Y receptors.
abstract: The neuropeptide Y system is known to be involved in the regulation of many central physiological and pathophysiological processes, such as energy homeostasis, obesity, cancer, mood disorders and epilepsy. Four Y receptor subtypes have been cloned from human tissue (hY1, hY2, hY4 and hY5) that form a multiligand/multireceptor system together with their three peptidic agonists (NPY, PYY and PP). Addressing this system for medical application requires on the one hand detailed information about the receptor-ligand interaction to design subtype-selective compounds. On the other hand comprehensive knowledge about alternative receptor signaling, as well as desensitization, localization and downregulation is crucial to circumvent the development of undesired side-effects and drug resistance. By bringing such knowledge together, highly potent and long-lasting drugs with minimized side-effects can be engineered. Here, current knowledge about Y receptor export, internalization, recycling, and degradation is summarized, with a focus on the human Y receptor subtypes, and is discussed in terms of its impact on therapeutic application.
authors: Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, Leipzig University, Bruderstra se 34, D-04103 Leipzig, Germany.
authors: Stefanie
authors: S
authors: Babilon
authors: Karin
authors: K
authors: Mörl
authors: Annette G
authors: AG
authors: Beck-Sickinger
mesh_terms: D000595:Amino Acid Sequence; D004705:Endocytosis; D006801:Humans; D008969:Molecular Sequence Data; D021381:Protein Transport; D059748:Proteolysis; D017476:Receptors, Neuropeptide Y / Q000032:analysis* / Q000378:metabolism*
chemical_list: D017476:Receptors, Neuropeptide Y