title: A follow-up study of autosomal dominant polycystic kidney disease with intracranial aneurysms using 3.0 T three-dimensional time-of-flight magnetic resonance angiography.
abstract: OBJECTIVE
  Autosomal dominant polycystic kidney disease (ADPKD) patients have an increased risk for intracranial aneurysms (IAs). Our aim was to screen and follow up the unruptured intracranial aneurysms (UIAs) detected by 3.0 T three-dimensional time-of-flight magnetic resonance angiography (3D-TOF MRA) in patients with ADPKD in order to evaluate the growth of UIAs and the value of 3D-TOF MRA.
  
  
  METHODS
  From 2011 to 2012, we followed up UIAs detected in 40 ADPKD patients who had MRA examinations with an interval of at least 36 months. All MRA examinations were performed on a 3T system (Achieva X-Series, Philips Medical Systems) with a Sense-Head-8 receiver head coil. The acquired data sets were transferred to a workstation (EWS, Philips Medical) to perform maximum intensity projection (MIP) and volume rendering (VR) with a specialized software package (Philips Medical). The size of UIAs was determined as the longest diameter in transverse or vertical measurement. UIAs that grew more than 20% were considered as enlarged.
  
  
  RESULTS
  Fifty UIAs were found in 40 previously examined ADPKD patients who underwent 3.0 T 3D-TOF MRA follow-ups. No patients ever had treatment before the second examination. The longest diameter of all follow-up UIAs was less than 10mm and mean diameter was 3.64 ± 2.25 mm. UIAs in only 4 patients (10%) were considered as enlarged. None of the 50 IAs in the 40 ADPKD patients ruptured during the MRA follow-up period.
  
  
  CONCLUSIONS
  3.0 T 3D-TOF MRA was feasible for UIAs follow-up in ADPKD patients. The chance of enlargement and rupture of UIAs in ADPKD patients was not higher than in the general population.
authors: Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors: Tao
authors: T
authors: Jiang
authors: Peng
authors: P
authors: Wang
authors: Yi
authors: Y
authors: Qian
authors: Xuan
authors: X
authors: Zheng
authors: Liaoyuan
authors: L
authors: Xiao
authors: Shengqiang
authors: S
authors: Yu
authors: Shiyuan
authors: S
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015984:Causality; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods / Q000706:statistics & numerical data*; D015994:Incidence; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D018810:Magnetic Resonance Angiography / Q000379:methods / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D011859:Radiography; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity
keywords: Autosomal dominant polycystic kidney disease; Follow-up; Intracranial aneurysms; Magnetic resonance angiography; Risk factor