title: Facile synthesis of versatile enantioenriched α-substituted hydroxy esters through a Brønsted acid catalyzed kinetic resolution.
abstract: An efficient synthesis of enantioenriched α-substituted γ-hydroxy esters via a kinetic resolution event is described. Bulky racemic esters in the presence of a chiral Brønsted acid selectively lactonize to yield a recoverable enantioenriched hydroxy ester and lactone. These esters are highly versatile building blocks that can readily be converted to synthetically useful materials.
authors: Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, USA.
authors: Ghassan
authors: G
authors: Qabaja
authors: Jennifer E
authors: JE
authors: Wilent
authors: Amanda R
authors: AR
authors: Benavides
authors: George E
authors: GE
authors: Bullard
authors: Kimberly S
authors: KS
authors: Petersen