title: Pentraxin 3 production in the adipose tissue and the skeletal muscle in diabetic-obese mice.
abstract: : Inflammation has been shown to promote obesity-induced insulin resistance. Although pentraxin (PTX) 3 is known as an anti-inflammatory factor, the effect of PTX3 on insulin sensitivity has not yet been elucidated. The aim of this study is to investigate a part of the role of PTX3 on insulin sensitivity. The authors studied the PTX3 and glucose transport protein expression levels in epididymal adipose tissue and soleus muscles of male diabetic-obese [Tsumura Suzuki obese-diabetic (TSOD)] and lean control mice. The levels of PTX3 in both skeletal muscle and adipose tissue were significantly lower in TSOD mice than in controls, and there was a significant positive correlation between them. They observed a significant positive correlation between PTX3 and glucose transport protein 4 levels in skeletal muscle. This study suggests that PTX3 may play a part of role as promoting insulin sensitivity of skeletal muscle in TSOD mice.
authors: Graduate School of Comprehensive Human Sciences (AM) and Faculty of Health and Sport Sciences (YC, SM), University of Tsukuba, Tsukuba, Japan.
authors: Asako
authors: A
authors: Miyaki
authors: Youngju
authors: Y
authors: Choi
authors: Seiji
authors: S
authors: Maeda
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism*; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D008820:Mice, Obese; D018482:Muscle, Skeletal / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D051275:Glucose Transporter Type 4; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C495693:Slc2a4 protein, mouse