title: Cost and burden of gastroesophageal reflux disease among patients with persistent symptoms despite proton pump inhibitor therapy: an observational study in France.
abstract: BACKGROUND
  Gastrointestinal reflux disease (GERD) is a common disorder that negatively impacts health-related quality of life (HRQL) and work productivity. Many patients have only a partial response to proton pump inhibitor (PPI) therapy and continue to experience GERD symptoms despite optimized treatment. This observational study aimed to provide information on symptoms, HRQL, resource usage, costs and treatment pathways associated with partial response to PPI therapy in French patients with GERD.
  
  
  METHODS
  Patients with partial response to PPI therapy, defined as persistent GERD symptoms ≥3 days/week despite optimized treatment with a PPI, were recruited for this 12-month observational study. GERD symptoms, HRQL, work productivity and resource use were assessed by patient surveys. Costs were calculated based on lost work productivity and resource use.
  
  
  RESULTS
  The patient population (n=262; mean age, 54 years; 40% men) carried a significant symptom burden, with 98% of patients having moderate-to-severe GERD symptoms and 65% of patients experiencing daily symptoms at baseline. HRQL and work productivity were significantly impaired, with a greater degree of impairment in patients with higher symptom burden. The mean total cost per patient over the 12-month follow-up period was €5237, of which €4674 (89%) was due to lost work productivity.
  
  
  CONCLUSIONS
  Partial response to PPI therapy for GERD is associated with a high symptom burden, significant impairment of HRQL and work productivity, and substantial GERD-related costs.
authors: Institut des Maladies de l'Appareil Digestif, University Hospital - CHU Hôtel Dieu, Place A Ricordeau, Nantes Cedex, 44093, France. stanislas.bruleydesvarannes@chu-nantes.fr
authors: Stanislas
authors: S
authors: Bruley des Varannes
authors: Helena Granstedt
authors: HG
authors: Löfman
authors: Maria
authors: M
authors: Karlsson
authors: Peter
authors: P
authors: Wahlqvist
authors: Magnus
authors: M
authors: Ruth
authors: Mary Lou
authors: ML
authors: Furstnau
authors: Nicolas
authors: N
authors: Despiégel
authors: Nils-Olov
authors: NO
authors: Stålhammar
mesh_terms: D017281:Cost of Illness; D005260:Female; D005602:France / Q000453:epidemiology; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000191:economics* / Q000453:epidemiology; D017048:Health Care Costs / Q000706:statistics & numerical data / Q000639:trends*; D006295:Health Resources / Q000706:statistics & numerical data; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D011788:Quality of Life / Q000523:psychology; D012189:Retrospective Studies; D016896:Treatment Outcome; D016526:Workload / Q000706:statistics & numerical data
chemical_list: D054328:Proton Pump Inhibitors