title: Depression is correlated with the psychological and physical aspects of sexual dysfunction in men.
abstract: Few studies have objectively examined the relationship between depression and various stages of sexual function. Here we associate depression and sexual function using validated questionnaires. A retrospective review of 186 men was performed; demographics and serum hormone levels were obtained. Responses to questionnaires evaluating depressive symptoms (Patient Health Questionnaire (PHQ-9)), sexual function (International Index of Erectile Function (IIEF)) and hypogonadal symptoms (quantitative Androgen Decline in the Aging Male (qADAM)) completed by each patient were correlated using Spearman's rank correlation. Mean±s.d. subject age: 52.6±12.7 years; mean serum hormone levels: TT 429.8±239.2 ng dl(-1), free testosterone 9.72±7.5 pg ml(-1) and estradiol 34.4±22.8 pg ml(-1). Negative correlations were observed between total PHQ-9 score and the sexual desire (ρ=-0.210, P=0.006), intercourse satisfaction (ρ=-0.293, P<0.0001) and overall satisfaction (ρ=-0.413, P<0.0001) domains of the IIEF and individual IIEF questions pertaining to erectile function. Men with a PHQ-9 score 10 (mild depression or worse), had lower sexual desire and sex life satisfaction. A negative correlation between PHQ-9 score and qADAM score (ρ=-0.634, P<0.0001) was observed and men with higher PHQ-9 score had lower qADAM scores. Depressive symptoms in men correlate with both psychological as well as physical aspects of sexual function.
authors: Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
authors: A W
authors: AW
authors: Pastuszak
authors: N
authors: N
authors: Badhiwala
authors: L I
authors: LI
authors: Lipshultz
authors: M
authors: M
authors: Khera
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology*; D007172:Erectile Dysfunction / Q000503:physiopathology / Q000523:psychology; D004958:Estradiol / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010549:Personal Satisfaction; D012189:Retrospective Studies; D012735:Sexual Dysfunction, Physiological / Q000503:physiopathology* / Q000523:psychology*; D020018:Sexual Dysfunctions, Psychological / Q000503:physiopathology* / Q000523:psychology*; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D004958:Estradiol