title: Occupational exposures and the development of new-onset asthma: a population-based cohort study from the ages of 13 to 44 years.
abstract: OBJECTIVE
  To evaluate the risk of asthma associated with occupational exposures in a population-based cohort.
  
  
  METHODS
  The risk of asthma was analyzed in 792 subjects who were asthma free at the age of 13 years. Occupational histories were obtained from subjects at the age of 44 years and occupational exposures determined with an asthma-specific job exposure matrix. Cumulative exposure to latex and risk of asthma was examined using Cox proportional hazards regression.
  
  
  RESULTS
  Development of asthma was modestly related to exposure at any time to high molecular weight latex (odds ratio, 1.4; 95% confidence interval, 0.9-2.3). Cumulative latex exposure of 6 to 15 years was associated with a hazard ratio of 1.6 for the development of asthma and after 16 years increased to 2.65 (95% confidence interval, 1.28-5.47).
  
  
  CONCLUSIONS
  There is a significant association between cumulative occupational exposure to latex and new-onset asthma.
authors: Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
authors: Ryan F
authors: RF
authors: Hoy
authors: John A
authors: JA
authors: Burgess
authors: Geza
authors: G
authors: Benke
authors: Melanie
authors: M
authors: Matheson
authors: Stephen
authors: S
authors: Morrison
authors: Lyle
authors: L
authors: Gurrin
authors: E Haydn
authors: EH
authors: Walters
authors: Shyamali C
authors: SC
authors: Dharmage
authors: Michael J
authors: MJ
authors: Abramson
mesh_terms: D000293:Adolescent; D000328:Adult; D059366:Asthma, Occupational / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D053208:Kaplan-Meier Estimate; D020315:Latex Hypersensitivity / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D016017:Odds Ratio; D016016:Proportional Hazards Models; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013648:Tasmania; D013997:Time Factors; D055815:Young Adult