title: Multicentre results of stereotactic body radiotherapy for secondary liver tumours.
abstract: BACKGROUND
  Surgical resection is the standard treatment for liver metastases, although for the majority of patients this is not possible. Stereotactic body radiotherapy (SBRT) is an alternative local-regional therapy. The purpose of this study was to evaluate the results of SBRT for secondary liver tumours from a combined multicentre database.
  
  
  METHODS
  Variables from patients treated with SBRT from four Academic Medical Centres were entered into a common database. Local tumour control and 1-year survival rates were calculated.
  
  
  RESULTS
  In total, 153 patients (91 women) 59 ± 8.4 years old with 363 metastatic liver lesions were treated with SBRT. The underlying primary tumour arose from gastrointestinal (GI), retroperitoneal and from extra-abdominal primaries in 56%, 8% and 36% of patients, respectively. Metastases, with a gross tumour volume (GTV) of 138.5 ± 126.8 cm(3) , were treated with a total radiation dose of 37.5 ± 8.2 Gy in 5 ± 3 fractions. The 1-year overall survival was 51% with an overall local control rate of 62% at a mean follow-up of 25.2 ± 5.9 months. A complete tumour response was observed in 32% of patients. Grade 3-5 adverse events were noted in 3% of patients.
  
  
  CONCLUSIONS
  Secondary liver tumours treated with SBRT had a high rate of local control with a low incidence of adverse events.
authors: Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.
authors: Betul
authors: B
authors: Berber
authors: Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.
authors: Rafael
authors: R
authors: Ibarra
authors: Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.
authors: Laura
authors: L
authors: Snyder
authors: Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.
authors: Min
authors: M
authors: Yao
authors: Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.
authors: Jeffrey
authors: J
authors: Fabien
authors: Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA.
authors: Michael T
authors: MT
authors: Milano
authors: Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA.
authors: Alan W
authors: AW
authors: Katz
authors: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors: Karyn
authors: K
authors: Goodman
authors: Department of Radiation Oncology, Cleveland Clinic Foundation, Lerner College, Cleveland, OH, USA.
authors: Kevin
authors: K
authors: Stephans
authors: Department of Surgery, Cleveland Clinic Foundation, Lerner College, Cleveland, OH, USA.
authors: Galal
authors: G
authors: El-Gazzaz
authors: Department of Surgery, Cleveland Clinic Foundation, Lerner College, Cleveland, OH, USA.
authors: Federico
authors: F
authors: Aucejo
authors: Department of Surgery, Cleveland Clinic Foundation, Lerner College, Cleveland, OH, USA.
authors: Charles
authors: C
authors: Miller
authors: Department of Surgery, Cleveland Clinic Foundation, Lerner College, Cleveland, OH, USA.
authors: John
authors: J
authors: Fung
authors: Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.
authors: Simon
authors: S
authors: Lo
authors: Department of Radiation Oncology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.
authors: Mitchell
authors: M
authors: Machtay
authors: Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.
authors: Juan
authors: J
authors: Sanabria
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D016634:Radiosurgery / Q000379:methods*; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D055815:Young Adult