title: Characterisation of changes in the haemostasis system in dogs with thrombosis.
abstract: OBJECTIVE
  To prospectively assess (2008 to 2009) all phases of coagulation including thromboelastography in dogs with thrombosis to determine if thrombosis is associated with hypercoagulable states.
  
  
  METHODS
  Coagulation reaction in dogs with thrombosis (n = 7) diagnosed by diagnostic imaging or histopathology was compared with 56 control dogs. Dogs pretreated with antiplatelet and anticoagulation drugs were excluded. Thromboelastographic G-values >10 · 3 Kdyn/cm(2) were used to define a hypercoagulable state.
  
  
  RESULTS
  Compared with the controls, there was a significantly higher mean platelet component indicating lower platelet activation status (17 · 99 ±1 · 36 versus 20 · 48 ±2 · 04 g/dL, P = 0 · 0004), increased thromboelastographic G-value (6 · 4 ±1 · 6 versus 13 · 1 ±6 · 2 Kdyn/cm(2) , P = 0 · 0029), activated partial thromboplastin time, fibrinogen, D-dimers (all: P < 0 · 0001) as well as decreased antithrombin (P = 0 · 0049), factor VIII (P < 0 · 0001), protein C (P < 0 · 0001), protein S (P = 0 · 0373) and activated protein C-ratio (P = 0 · 0013). On the basis of thromboelastographic G-value, three of six thromboelastographic tracings were classified as normocoagulable and three as hypercoagulable.
  
  
  CONCLUSIONS
  In dogs with thrombosis, both normo- and hypercoagulable states are present and activated protein C resistance is common.
authors: Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology, Justus-Liebig University Giessen, Giessen, Germany.
authors: N
authors: N
authors: Bauer
authors: A
authors: A
authors: Moritz
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001780:Blood Coagulation Tests / Q000662:veterinary; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D006706:Homeostasis / Q000502:physiology*; D008297:Male; D011446:Prospective Studies; D013927:Thrombosis / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*