title: [Bone histology after intermittent PTH treatment - animal models -].
abstract: Intermittent administration of parathyroid hormone, PTH, appears to promote preosteoblastic proliferation and osteoblastic bone formation, giving rise to anabolic effect in bone. We investigated the behavior of osteoblastic cells after intermittent PTH treatment and attempted to elucidate the role of osteoclasts on the mediation of PTH-driven bone anabolism. As a consequence, bone formation was increased in PTH-treated wild-type mice, whereas in the osteoclast-deficient c-fos - / - mice, there was no significant increase in bone formation, despite the highly-increased population of preosteoblasts. It seems likely that the absence of osteoclasts might hinder PTH-driven bone anabolism, and also that osteoclastic presence may be necessary for full osteoblastic differentiation and enhanced bone formation seen after intermittent PTH administration. We will also discuss the pivotal role of osteocytes in PTH-mediated anabolic effect.
authors: Department of Developmental Biology of Hard Tissue, Hokkaido University, Sapporo, Japan.
authors: Muneteru
authors: M
authors: Sasaki
authors: Tomoka
authors: T
authors: Hasegawa
authors: Hiromi
authors: H
authors: Hongo
authors: Tomomaya
authors: T
authors: Yamamoto
authors: Norio
authors: N
authors: Amizuka
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D023421:Models, Animal; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D010281:Parathyroid Hormone / Q000494:pharmacology*
chemical_list: D010281:Parathyroid Hormone