title: Copper-catalyzed aldol-type addition of ketones to aromatic nitriles: a simple approach to enaminone synthesis.
abstract: An efficient method for the synthesis of enaminones is described. The aldol-type addition of ketones to aromatic nitriles proceeded smoothly in the presence of a simple copper catalyst system (CuI-2,2'-bipyridine-NaO(t)Bu) in N,N-dimethylformamide. Enaminones in satisfactory to excellent yields were produced using this technique.
authors: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China. yuxiaoqiang@dlut.edu.cn
authors: Xiaoqiang
authors: X
authors: Yu
authors: Longxiang
authors: L
authors: Wang
authors: Xiujuan
authors: X
authors: Feng
authors: Ming
authors: M
authors: Bao
authors: Yoshinori
authors: Y
authors: Yamamoto
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001596:Benzylamines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D001596:Benzylamines; D047188:Chalcones; D007659:Ketones; D009570:Nitriles; D003300:Copper; C116609:3-hydroxybutanal