title: Local and systemic oxidative stress status in chronic obstructive pulmonary disease patients.
abstract: BACKGROUND
  Previous studies have indicated that oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD).
  
  
  OBJECTIVE
  To study local and systemic oxidative stress status in COPD patients, and to clarify the relationship between local and systemic oxidative stress.
  
  
  METHODS
  Lipid peroxide malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and GSH peroxidase (GSH-PX) levels in induced sputum and plasma, as well as glucocorticoid receptor (GR) levels in peripheral blood leukocytes were examined in 43 acute exacerbation of COPD patients (group A), 35 patients with stable COPD (group B) and 28 healthy controls (14 smokers [group C]; 14 nonsmokers [group D]).
  
  
  RESULTS
  MDA levels in induced sputum and plasma decreased progressively in groups A to D, with significant differences between any two groups (P<0.001). GSH, SOD and GSH-PX levels in both induced sputum and plasma increased progressively in groups A to D, with significant differences between any two groups (P<0.001). GR levels in peripheral blood leukocytes decreased progressively in groups D to A (all comparisons P<0.001). Pearson analysis revealed strong correlations between MDA, GSH, SOD and GSH-PX levels in plasma and induced sputum. The activity of SOD in plasma and sputum were both positively correlated with GR levels (partial correlation coefficients 0.522 and 0.574, respectively [P<0.001]).
  
  
  CONCLUSIONS
  Oxidative stress levels were elevated in COPD patients. There was a correlation between local and systemic oxidative status in COPD, and between decreased SOD activity and decreased GR levels in COPD patients.
authors: Department of Respiratory Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China. zengmian2004@163.com
authors: Mian
authors: M
authors: Zeng
authors: Yue
authors: Y
authors: Li
authors: Yujie
authors: Y
authors: Jiang
authors: Guifang
authors: G
authors: Lu
authors: Xiaomei
authors: X
authors: Huang
authors: Kaipan
authors: K
authors: Guan
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000737:chemistry / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000032:analysis / Q000378:metabolism
chemical_list: D011965:Receptors, Glucocorticoid