title: Evaluation of humoral immune function in patients with chronic idiopathic thrombocytopenic purpura.
abstract: Coincidence of autoimmune diseases such as immune thrombocytopenic purpura (ITP) with immunodeficiencies has been reported previously in patients who suffered from primary antibody deficiency (PAD). But there is no original study on immunological profiles of ITP patients to find out their probable immune deficiency. In this case-control study, ITP patients' humoral immunity was investigated for diagnosis of PAD in comparison with normal population. To evaluate the humoral immune system against polysaccharide antigens, patients' serum immunoglobulin levels were measured and a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) was administrated to evaluate the antibody response to vaccination. In this study, 14 out of 36 patients (39%) were diagnosed with antibody mediated immune deficiency including 2 patients (5.5%) with immunoglobulin class deficiency and 4 (11%) with IgG subclass deficiency. The remaining patients suffered from specific antibody deficiency. The most frequent deficiency in ITP patients was specific antibody deficiency.Therefore, immunological survey on ITP patients may be important especially for those who have undergone splenectomy.
authors: Research Center for Immunodeficiencies, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran. aghamohammadi@sina.tums.ac.ir.
authors: Mohammad Saeid
authors: MS
authors: Rahiminejad
authors: Mehrdad
authors: M
authors: Mirmohammad Sadeghi
authors: Payam
authors: P
authors: Mohammadinejad
authors: Bamdad
authors: B
authors: Sadeghi
authors: Hassan
authors: H
authors: Abolhassani
authors: Mohammad Mehdi
authors: MM
authors: Dehghani Firoozabadi
authors: Seyed Mohammad
authors: SM
authors: Fathi
authors: Hamid
authors: H
authors: Rezvani
authors: Gholamreza
authors: G
authors: Bahoush
authors: Mohammad Ali
authors: MA
authors: Ehsani
authors: Mohammad
authors: M
authors: Faranoush
authors: Azim
authors: A
authors: Mehrvar
authors: Babak
authors: B
authors: Torabi Sagvand
authors: Mojtaba
authors: M
authors: Ghadiani
authors: Nima
authors: N
authors: Rezaei
authors: Asghar
authors: A
authors: Aghamohammadi
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D017074:Common Variable Immunodeficiency / Q000097:blood* / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D056724:Immunity, Humoral / Q000187:drug effects*; D007070:Immunoglobulin A / Q000097:blood* / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood* / Q000145:classification / Q000276:immunology; D008297:Male; D008875:Middle Aged; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood* / Q000150:complications / Q000276:immunology; D013156:Splenectomy
chemical_list: C414006:23-valent pneumococcal capsular polysaccharide vaccine; D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines