title: microRNA biogenesis and turnover in plants.
abstract: microRNAs (miRNAs) are short RNAs that regulate gene expression in eukaryotes. The biogenesis and turnover of miRNAs determine their spatiotemporal accumulation within tissues. miRNA biogenesis is a multistep process that entails transcription, processing, nuclear export, and formation of the miRNA-ARGONAUTE complex. Factors that perform each of these steps have been identified. Generation of mature miRNAs from primary transcripts, i.e., miRNA processing, is a key step in miRNA biogenesis. Our understanding of miRNA processing has expanded beyond the enzyme that performs the reactions, as more and more additional factors that impact the efficiency and accuracy of miRNA processing are uncovered. In contrast to miRNA biogenesis, miRNA turnover is an important but poorly understood process that contributes to the steady-state levels of miRNAs. Enzymes responsible for miRNA degradation have only recently been identified. This review describes the processes of miRNA maturation and degradation in plants.
authors: Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, California 92521, USA.
authors: K
authors: K
authors: Rogers
authors: X
authors: X
authors: Chen
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000235:genetics; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D010944:Plants / Q000235:genetics*; D018749:RNA, Plant / Q000096:biosynthesis* / Q000235:genetics; D034743:RNA-Induced Silencing Complex / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs; D018749:RNA, Plant; D034743:RNA-Induced Silencing Complex