title: A fast process for imprinting micro and nano patterns on electrospun fiber meshes at physiological temperatures.
abstract: Electrospun fiber meshes are patterned at length scales comparable to or lower than their fiber diameter. Simple nano- and microgrooves and closed geometric shapes are imprinted in different tones using a fast imprint process at physiological temperatures. Human mesenchymal stromal cells cultured on patterned scaffolds show differences in cellular morphology and cytoskeleton organization. Microgrooved electrospun fibers support upregulation of alkaline phosphatase and bone morphogenetic protein-2 gene expression when cells are cultured in osteogenic medium.
authors: Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands.
authors: Anandkumar
authors: A
authors: Nandakumar
authors: Roman
authors: R
authors: Truckenmüller
authors: Maqsood
authors: M
authors: Ahmed
authors: Febriyani
authors: F
authors: Damanik
authors: Diogo Reis
authors: DR
authors: Santos
authors: Nils
authors: N
authors: Auffermann
authors: Jan
authors: J
authors: de Boer
authors: Pamela
authors: P
authors: Habibovic
authors: Clemens
authors: C
authors: van Blitterswijk
authors: Lorenzo
authors: L
authors: Moroni
mesh_terms: D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D003599:Cytoskeleton / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D054802:Molecular Imprinting / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*; D011108:Polymers / Q000494:pharmacology; D013194:Staining and Labeling; D013696:Temperature; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D011108:Polymers
keywords: biomedical engineering; electrospinning; fibers; patterning; physiological temperatures