title: Is instability good for the brain?
abstract: In this issue of Neuron, Nahm et al. (2013) examine the Drosophila ortholog of spartin, the human gene mutated in a form of hereditary spastic paraplegia. Spartin inhibits BMP signaling and upregulation of BMP signaling may increase microtubule stability and neurodegeneration.
authors: Broad Center, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
authors: Robert A
authors: RA
authors: Carrillo
authors: Kaushiki
authors: K
authors: Menon
authors: Kai
authors: K
authors: Zinn
mesh_terms: D052004:Bone Morphogenetic Protein Receptors / Q000235:genetics* / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000235:genetics* / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging*; D029721:Drosophila Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D011877:Radionuclide Imaging; D011956:Receptors, Cell Surface / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D019485:Bone Morphogenetic Proteins; D029721:Drosophila Proteins; D011956:Receptors, Cell Surface; D052004:Bone Morphogenetic Protein Receptors