title: Isolation, structure elucidation, and iron-binding properties of lystabactins, siderophores isolated from a marine Pseudoalteromonas sp.
abstract: The marine bacterium Pseudoalteromonas sp. S2B, isolated from the Gulf of Mexico after the Deepwater Horizon oil spill, was found to produce lystabactins A, B, and C (1-3), three new siderophores. The structures were elucidated through mass spectrometry, amino acid analysis, and NMR. The lystabactins are composed of serine (Ser), asparagine (Asn), two formylated/hydroxylated ornithines (FOHOrn), dihydroxy benzoic acid (Dhb), and a very unusual nonproteinogenic amino acid, 4,8-diamino-3-hydroxyoctanoic acid (LySta). The iron-binding properties of the compounds were investigated through a spectrophotometric competition.
authors: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, United States.
authors: Hannah K
authors: HK
authors: Zane
authors: Alison
authors: A
authors: Butler
mesh_terms: D001216:Asparagine / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D005841:Gentisates / Q000737:chemistry; D060851:Gulf of America; D007501:Iron / Q000737:chemistry* / Q000378:metabolism; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009952:Ornithine / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification*; D059392:Petroleum Pollution; D031161:Pseudoalteromonas / Q000737:chemistry*; D012694:Serine / Q000737:chemistry; D017262:Siderophores / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D005841:Gentisates; D010456:Peptides, Cyclic; D017262:Siderophores; C582755:lystabactin A; C582757:lystabactin B; C582756:lystabactin C; C084558:alterobactin A; D012694:Serine; D001216:Asparagine; D007501:Iron; D009952:Ornithine