title: Differentiated thyroid carcinoma in a girl with resistance to thyroid hormone management with triiodothyroacetic acid.
abstract: Thyroid hormone resistance syndrome is characterized by a reduced target tissue response to the action of thyroid hormone, which leads to high levels of free thyroxine and free triiodothyronine with non-suppressed levels of thyrotropin (TSH). Recently, three cases of papillary thyroid carcinoma associated with thyroid hormone resistance syndrome were published. The main challenge in this situation is the difficulty of maintaining the suppression of TSH levels without producing symptoms of hyperthyroidism. We present another case of an association of thyroid hormone resistance syndrome and papillary thyroid carcinoma, and we share our experience with 3,5,3'-triiodothyroacetic acid, which made possible an easier management of the carcinoma after surgery, maintaining the TSH levels suppressed despite the resistance to thyroid hormones.
authors: C/San Ignacio de Loyola, Valencia, Spain. agustinprol@hotmail.com
authors: Agustín
authors: A
authors: Ramos-Prol
authors: María
authors: M
authors: Antonia Pérez-Lázaro
authors: María
authors: M
authors: Isabel del Olmo-García
authors: Beatriz
authors: B
authors: León-de Zayas
authors: Francisca
authors: F
authors: Moreno-Macián
authors: Soledad
authors: S
authors: Navas-de Solis
authors: Juan Francisco
authors: JF
authors: Merino-Torres
mesh_terms: D002277:Carcinoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D002291:Carcinoma, Papillary; D002454:Cell Differentiation; D002648:Child; D005260:Female; D006801:Humans; D000077273:Thyroid Cancer, Papillary; D013960:Thyroid Function Tests; D018382:Thyroid Hormone Resistance Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013964:Thyroid Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D017211:Treatment Failure; D014284:Triiodothyronine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D014284:Triiodothyronine; C010642:3,3',5-triiodothyroacetic acid