title: Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes.
abstract: BACKGROUND
  Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and metabolic control was examined.
  
  
  RESULTS
  We conducted a post-hoc analysis of a double-blind, placebo-controlled study of calcitriol supplementation to preserve β-cell function. 27 recent-onset T1D subjects, mean age 22 years, were randomized to 0.25 µg calcitriol per day or placebo (1:1) and followed up for one year. Changes in bone formation (osteoclacin) and resorption (beta-CrossLaps) markers, and differences between placebo and calcitriol-treated group were evaluated. At baseline, osteocalcin levels were significantly lower in female than in male patients (P<0.01) while no other metabolic parameters as HbA1c and C-peptide differed between gender. No significant correlations were found in relation to HbA1c, insulin requirement and C-peptide. At 1 year follow-up, no significant differences were observed between calcitriol and placebo groups for osteocalcin and β-CrossLaps. In the placebo group osteocalcin levels were unrelated with parameters of metabolic control, such as C-peptide, insulin requirement or HbA1c. Changes of C-peptide, insulin requirement and HbA1c were not related to osteocalcin levels.
  
  
  CONCLUSIONS
  Supplementation with 0.25 µg calcitriol per day to patients with new-onset T1D does not affect circulating markers of bone turnover. OC levels were unrelated to β-cell function and other metabolic parameters suggesting that OC is ineffective to control pancreatic function in presence of aggressive autoimmune destruction.
authors: Department of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, Italy.
authors: Nicola
authors: N
authors: Napoli
authors: Rocky
authors: R
authors: Strollo
authors: Dario
authors: D
authors: Pitocco
authors: Carla
authors: C
authors: Bizzarri
authors: Ernesto
authors: E
authors: Maddaloni
authors: Daria
authors: D
authors: Maggi
authors: Silvia
authors: S
authors: Manfrini
authors: Ann
authors: A
authors: Schwartz
authors: Paolo
authors: P
authors: Pozzilli
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001862:Bone Resorption / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002117:Calcitriol / Q000008:administration & dosage*; D002648:Child; D003094:Collagen / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D050417:Insulin-Secreting Cells / Q000187:drug effects; D008297:Male; D015675:Osteocalcin / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects*; D010446:Peptide Fragments / Q000097:blood; D014807:Vitamin D / Q000378:metabolism*
chemical_list: D002096:C-Peptide; D002117:Calcitriol; D003094:Collagen; D006442:Glycated Hemoglobin; D007328:Insulin; D015675:Osteocalcin; D010446:Peptide Fragments; D014807:Vitamin D; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; C517652:hemoglobin A1c protein, human