title: Prenatal diagnosis and treatment perspective of fetal hypothyroidism with goiter.
abstract: We describe two cases of fetal goiter in women with no history of thyroid disease. Diagnosis of fetal goiter during antenatal care was made by ultrasound and MRI. Congenital hypothyroidism was confirmed by fetal blood sampling that was treated with weekly intra-amniotic injections of L-thyroxin. One fetus was initially treated with four weekly intra-amniotic injections of 200 μgms of L-thyroxin, later increased to 400 μgms. The other fetus was treated with only three weekly intraamniotic injections of 400 μgms of L-thyroxin. Therapeutic response was monitored by repeated ultrasound and MRI along with fetal blood sampling. At birth, none of the babies had goiter and were put on oral thyroxin. Post-natal studies were suggestive of congenital hypothyroidism due to dyshormogenesis. No abnormality was detected at follow-up. These cases highlight the role of intra-amniotic thyroxine in management of fetal hypothyroidism with goiter.
authors: Department of Obstetrics and Gynaecology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. agulraze@gmail.com
authors: Anjum
authors: A
authors: Gulraze
authors: Wesam
authors: W
authors: Kurdi
authors: Maha
authors: M
authors: Tulbah
authors: Faraz Azim
authors: FA
authors: Niaz
mesh_terms: D000328:Adult; D003409:Congenital Hypothyroidism / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005312:Fetal Blood; D005315:Fetal Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D005865:Gestational Age; D006042:Goiter / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011248:Pregnancy Complications; D011296:Prenatal Diagnosis; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal
chemical_list: D013974:Thyroxine