title: Sex peptides and MIPs can activate the same G protein-coupled receptor.
abstract: In many animal species, copulation elicits a number of physiological and behavioral changes in the female partner. In Drosophila melanogaster, the main molecular effector of these physiological responses has been identified as sex peptide (SP). The sex peptide receptor (SPR) has been characterized and recently, its activation by Drosophila myoinhibiting peptides (MIPs)-in addition to SP-has been demonstrated. The myoinhibiting peptides are members of a conserved peptide family, also known as B-type allatostatins, which generally feature the C-terminal motif -WX6Wamide.
authors: KU Leuven, Animal Physiology and Neurobiology, Naamsestraat 59, P.O. Box 2465, Leuven, Belgium. hanspeter.vandersmissen@bio.kuleuven.be
authors: Hans Peter
authors: HP
authors: Vandersmissen
authors: Ronald J
authors: RJ
authors: Nachman
authors: Jozef
authors: J
authors: Vanden Broeck
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D005260:Female; D008297:Male; D010455:Peptides / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D010455:Peptides; D043562:Receptors, G-Protein-Coupled