title: [Renal adaptation after experimental nephrectomy in animals: a review].
abstract: OBJECTIVE AND DATA-GATHERING: We reviewed experimental litterature about kidney adaptation after nephrectomy in mammals. KNOWLEDGE SYNTHESIS: Renal mass increases after nephrectomy thanks to two components, one is immediately due to the rise of glomulary capillary vascular flow, other is linked to cellular modifications with hyperplasia stage which precedes hypertrophy stage. After nephrectomy, young animals show higher renal adaptability than adults. Similarly, the sex influences the remnant kidney parenchyma volume, the increase of glomerular filtration, the hyperplasia's intensity or length, the hypertrophy's metabolic pathways and the glomerular and tubular cells' injury. There is no question that renal compensatory is regulated by hormones such as IGF-1, TGFβ-1 and Ang-II.
authors: Service urologie-andrologie-transplantation, CHU Rangueil, 1, avenue Jean-Poulhès, TSA 50032, 31059 Toulouse cedex, France. terraderouvellat@gmail.com
authors: P
authors: P
authors: Rouvellat-Terrade
authors: X
authors: X
authors: Game
authors: G
authors: G
authors: de Bonnecaze
authors: J-B
authors: JB
authors: Beauval
authors: A
authors: A
authors: Mansouri
authors: N
authors: N
authors: Doumerc
authors: P
authors: P
authors: Rischmann
authors: B
authors: B
authors: Malavaud
mesh_terms: D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D005919:Glomerular Filtration Rate; D006984:Hypertrophy; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007668:Kidney / Q000254:growth & development* / Q000473:pathology / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000254:growth & development / Q000503:physiopathology; D009392:Nephrectomy; D020127:Recovery of Function; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D014662:Vasoconstrictor Agents / Q000378:metabolism
chemical_list: D053773:Transforming Growth Factor beta1; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D007334:Insulin-Like Growth Factor I