title: Repetitive transcranial magnetic stimulation not beneficial in severe choreiform movements of Huntington disease.
abstract: Repetitive transcranial magnetic stimulation (rTMS) has been used therapeutically for reducing choreiform movements in patients with Huntington disease. There have been case studies reporting improvement in choreiform movements with administration of low-frequency rTMS lasting for a brief period. We report a case series where application of 7 consecutive sessions of bilateral low-frequency rTMS over the scalp area corresponding to supplementary motor area in patients with severe Huntington chorea did not reduce the intensity of choreiform movements even transiently. Hence, the proposed role of rTMS in reducing intensity of choreiform movements by altering neuronal plasticity may not hold true in severe cases.
authors: Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India. aniketdshukla@gmail.com
authors: Aniket
authors: A
authors: Shukla
authors: Rajan Nishanth
authors: RN
authors: Jayarajan
authors: Kesavan
authors: K
authors: Muralidharan
authors: Sanjeev
authors: S
authors: Jain
mesh_terms: D002819:Chorea / Q000209:etiology / Q000628:therapy*; D004185:Disability Evaluation; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D017211:Treatment Failure