title: Increasing incidence of paediatric inflammatory bowel disease in northern Stockholm County, 2002-2007.
abstract: OBJECTIVE
  A sharp increase in paediatric (younger than 16 years) inflammatory bowel disease (IBD) incidence was observed in northern Stockholm County, Sweden, in 1990-2001. The increasing incidence was primarily explained by a rising incidence of Crohn disease (CD). Here, we present an update on the trends in incidence of paediatric IBD, 2002-2007.
  
  
  METHODS
  Medical records of all children diagnosed as having suspected IBD in northern Stockholm County, 2002-2007, were scrutinised using defined diagnostic criteria. Disease extension, localisation, and behaviour at diagnosis were classified within the framework of the Paris classification.
  
  
  RESULTS
  A total of 133 children were diagnosed as having IBD 2002-2007 corresponding to a sex- and age-standardised incidence (per 10 person-years) for paediatric IBD of 12.8 (95% CI 10.8-15.2). The standardised incidence was 9.2 (95% CI 7.5-11.2) for CD and 2.8 (95% CI 1.9-4.0) for ulcerative colitis (UC). A significant increasing incidence of UC (P < 0.05) was observed during the study period. No temporal trend was observed for the incidence of CD.
  
  
  CONCLUSIONS
  The incidence rate of paediatric IBD in northern Stockholm was significantly higher in 2002-2007 than that observed in our earlier study covering 1990-2001. The former sharp increase in incidence of paediatric CD seems, however, to have levelled out, although at a higher rate than reported from most other regions in the world. Although CD was still predominant, the observed increase in incidence of UC during the study period is notable.
authors: Department of Women's and Children's Health, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. petter.malmborg@karolinska.se
authors: Petter
authors: P
authors: Malmborg
authors: Lena
authors: L
authors: Grahnquist
authors: Johan
authors: J
authors: Lindholm
authors: Scott
authors: S
authors: Montgomery
authors: Hans
authors: H
authors: Hildebrand
mesh_terms: D000293:Adolescent; D002391:Catchment Area, Health; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000453:epidemiology; D003424:Crohn Disease / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D019456:Health Transition; D006801:Humans; D015994:Incidence; D007223:Infant; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology*; D008297:Male; D008499:Medical Records; D011159:Population Surveillance; D011446:Prospective Studies; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology