title: A noninvasive tumor oxygenation imaging strategy using magnetic resonance imaging of endogenous blood and tissue water.
abstract: OBJECTIVE
  To present a novel imaging strategy for noninvasive measurement of tumor oxygenation using MR imaging of endogenous blood and tissue water.
  
  
  METHODS
  The proposed approach for oxygen partial pressure (pO2) estimation is based on intravoxel incoherent motion diffusion MRI and the dependence of the blood R2 relaxation rate on the inter-echo spacing measured using a multiple spin-echo Carr-Purcell-Meiboom-Gill sequence and weak-field diffusion model. The accuracy of the approach was validated by comparison with (19)F MRI oximetry.
  
  
  RESULTS
  The results in eight rats at 4.7 T showed that tumors have longer T1 (1980 ± 186 ms) and T2 (59 ± 9 ms) relaxation times, heterogeneous blood volume fraction (0.23 ± 0.1), oxygen saturation level (Y) (0.53 ± 0.12), and pO2 (36 ± 15 mmHg) distributions compared with normal muscle (T1 1480 ± 86 ms, T2 29 ± 2 ms, blood volume fraction 0.22 ± 0.03, Y 0.49 ± 0.06, and pO2 39 ± 5 mmHg). pO2 estimates based on the novel (1)H approach were essentially identical with (19)F observations.
  
  
  CONCLUSIONS
  The study indicates that noninvasive measurement of tumor pO2 using (1)H MRI derived multiparametric maps is feasible and could become a valuable tool to evaluate tumor hypoxia.
authors: Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
authors: Zhongwei
authors: Z
authors: Zhang
authors: Rami R
authors: RR
authors: Hallac
authors: Peter
authors: P
authors: Peschke
authors: Ralph P
authors: RP
authors: Mason
mesh_terms: D000818:Animals; D001769:Blood; D001834:Body Water; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009374:Neoplasms, Experimental / Q000378:metabolism*; D010092:Oximetry; D010100:Oxygen / Q000032:analysis*; D010313:Partial Pressure; D051381:Rats
chemical_list: D010100:Oxygen