title: Metastasis: New insights into organ-specific extravasation and metastatic niches.
abstract: The appearance of clinically detectable metastases is the end-point of a complex set of biological processes only few cancer cells are capable to complete. Metastatic colonization comprises the most inefficient metastatic steps as it requires a fine-tuned crosstalk between the disseminated cancer (stem) cells and their host microenvironment. The origin of the cancer cell and its intrinsic properties are factors that together with the organ microenvironment and circulation patterns determine the site of metastatic spread, the dormancy period and the extent of metastasis formation. Recent advances provide novel insights into the molecular components required for organ-specific infiltration, the composition of growth-supportive metastatic niches in different tissues and the cancer cell-niche crosstalk.
authors: Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research "Molecular Oncology", 1015 Lausanne, Switzerland.
authors: Anja
authors: A
authors: Irmisch
authors: Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research "Molecular Oncology", 1015 Lausanne, Switzerland. Electronic address: joerg.huelsken@epfl.ch.
authors: Joerg
authors: J
authors: Huelsken
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D009928:Organ Specificity
keywords: Cancer stem cell; Colonization; Extravasation; Metastasis; Niche