title: Tuneable nanochannel formation for sample-in/answer-out devices.
abstract: Control of the dielectric breakdown of PDMS was achieved by limiting the current during the breakdown process. This enabled tuning of the nanochannel pore size and hence their permeability for molecules of different molecular weights. This method enabled the analysis of the drug quinine from whole blood in 3 min using a simple, disposable microfluidic device.
authors: Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Private Bag 75, Hobart, Tasmania 7001, Australia.
authors: Aliaa I
authors: AI
authors: Shallan
authors: Adam J
authors: AJ
authors: Gaudry
authors: Rosanne M
authors: RM
authors: Guijt
authors: Michael C
authors: MC
authors: Breadmore
mesh_terms: D000818:Animals; D002417:Cattle; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D058608:Nanopores; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D012235:Rhodamines / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004129:Dimethylpolysiloxanes; D012235:Rhodamines; C026188:rhodamine 6G; D012710:Serum Albumin, Bovine