title: Aplysqualenols A and B: Squalene-Derived Polyethers with Antitumoral and Antiviral Activity from the Caribbean Sea SlugAplysia dactylomela.
abstract: The novel bromotriterpene polyethers aplysqualenol A (1) and aplysqualenol B (2) have been isolated from the Caribbean sea slugAplysia dactylomelacollected in Puerto Rico, and their structures and relative configurational assignments established from spectroscopic data aided by quantum mechanical calculations of NMR chemical shifts. Although both these compounds may be conceived as polyoxycyclic derivatives of the C30 squalene skeleton, remarkably1and2possess an unprecedented C15 to C24 flexible chain of 14S* spatial disposition that contains a unique ether bridge between C16 and C19. Biological activity screening tests revealed that, although aplysqualenol A (1) does not have significant anti-infective properties, it possesses potent antitumoral and antiviral activities.
authors: Department of Chemistry, University of Puerto Rico, P.O. Box 23346, U. P. R. Station, San Juan.
authors: Brunilda
authors: B
authors: Vera
authors: Abimael D
authors: AD
authors: Rodríguez
authors: Edward
authors: E
authors: Avilés
authors: Yasuyuki
authors: Y
authors: Ishikawa
keywords: Antitumor activity; Antiviral activity; Aplysia dactylomela; Polyether; Sea slug