title: Synthesis of 1-aminoisoquinolines by gold(III)-mediated domino reactions from 2-alkynylbenzamides and ammonium acetate.
abstract: A facile synthetic route toward pharmaceutically interesting 1-aminoisoquinoline derivatives by gold(III)-mediated domino reactions is described. This synthetic protocol starts from readily available 2-alkynylbenzamides and ammonium acetate and takes place under mild reaction conditions compatible with a variety of functional groups. A plausible mechanism for the domino process is proposed, supported by the reaction of a possible intermediate, N-(3-phenyl-1H-isochromen-1-ylidene)propan-1-amine.
authors: Department of Chemistry and Biochemistry, Queens College and the Graduate Center of the City University of New York, 65-30 Kissena Boulevard, Flushing, New York 11367, United States.
authors: Yuhua
authors: Y
authors: Long
authors: Zhigang
authors: Z
authors: She
authors: Xiaochen
authors: X
authors: Liu
authors: Yu
authors: Y
authors: Chen
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000085:Acetates; D000480:Alkynes; D001549:Benzamides; D007546:Isoquinolines; D006046:Gold; C041545:1-aminoisoquinoline; C018824:ammonium acetate