title: Relationship of neonatal cerebral blood flow velocity asymmetry with early motor, cognitive and language development in term infants.
abstract: The objective of this study was to examine the relationships of Doppler cerebral blood flow velocity (CBFV) asymmetry measures with developmental outcomes in term infants. Doppler CBFV parameters (peak systolic velocity [PSV] and mean velocity [MV]) of the bilateral middle cerebral arteries of 52 healthy term infants were prospectively examined on postnatal days 1-5, and then their motor, cognitive and language development was evaluated with the Bayley Scales of Infant and Toddler Development, Third Edition, at 6, 12, 18 and 24 months of age. The left CBFV asymmetry measure (PSV or MV) was calculated by subtracting the right-side value from the left-side value. Left CBFV asymmetry measures were significantly positively related to motor scores at 6 (r = 0.3-0.32, p < 0.05) and 12 (r = 0.35, p < 0.05) months of age, but were not related to cognitive or language outcome. Thus, the leftward hemodynamic status of the middle cerebral arteries, as measured by cranial Doppler ultrasound in the neonatal period, predicts early motor outcome in term infants.
authors: School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors: Ying-Chin
authors: YC
authors: Wu
authors: Wu-Shiun
authors: WS
authors: Hsieh
authors: Chyong-Hsin
authors: CH
authors: Hsu
authors: Nan-Chang
authors: NC
authors: Chiu
authors: Hung-Chieh
authors: HC
authors: Chou
authors: Chien-Yi
authors: CY
authors: Chen
authors: Shinn-Forng
authors: SF
authors: Peng
authors: Han-Yang
authors: HY
authors: Hung
authors: Jui-Hsing
authors: JH
authors: Chang
authors: Wei J
authors: WJ
authors: Chen
authors: Suh-Fang
authors: SF
authors: Jeng
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D058245:Cognitive Reserve / Q000502:physiology*; D004453:Echoencephalography / Q000379:methods; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007804:Language Development; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic