title: miRNAs: their discovery, biogenesis and mechanism of action.
abstract: The field of miRNA research is evolving at a very fast pace. Since their discovery almost 20years ago, miRNAs have proven to be of tremendous importance to normal physiological homeostasis as well as to the pathogenesis of major diseases such as cancer. Recent advances describe a key contribution for miRNAs in a wide variety of cellular processes ranging from embryonic development, cell proliferation and apoptosis to prominent roles in disease progression. miRNAs are now of central interest to biomedical research. Here we provide an overview of their discovery, biogenesis and mechanism of action.
authors: Department of Clinical Biochemistry, Maisonneuve-Rosemont Hospital, 5415 Boulevard de l'Assomption, Montréal, Québec, H1T 2M4, Canada. nicolas.tetreault@gmail.com
authors: N
authors: N
authors: Tétreault
authors: V
authors: V
authors: De Guire
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D047108:Embryonic Development; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D012334:RNA, Neoplasm