title: Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma.
abstract: BACKGROUND
  The use of many of the standard skin-directed mycosis fungoides (MF) therapies on facial skin may be limited by site-specific increased risks of side effects, excessive inflammation, and ocular toxicity.
  
  
  OBJECTIVE
  Our study aimed to describe the levels of erythema, scale, and induration of facial lesions in MF before and after low-dose high-dose-rate surface applicator brachytherapy and to examine the overall clinical response to brachytherapy.
  
  
  METHODS
  A total of 23 facial MF lesions in 10 patients were treated with high-dose-rate brachytherapy doses of 4 Gy per session for a total of 2 fractions at our multidisciplinary cutaneous oncology clinic between August 17, 2009, and March 12, 2012.
  
  
  RESULTS
  In all 23 lesions, dramatic clinical improvement was observed. Patients were followed up for a median of 6.3 months. No recurrences were reported in the follow-up period.
  
  
  CONCLUSIONS
  Long-term follow-up is lacking. Reassessment of all included patients at annual intervals for a period of at least 5 years is the authors' goal.
  
  
  CONCLUSIONS
  Low-dose high-dose-rate brachytherapy using custom-made surface molds is a highly efficacious therapy in the treatment of facial lesions in MF.
authors: Department of Dermatology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors: Jennifer A
authors: JA
authors: DeSimone
authors: Emmanuella
authors: E
authors: Guenova
authors: Joi B
authors: JB
authors: Carter
authors: Keri S
authors: KS
authors: Chaney
authors: Julie R
authors: JR
authors: Aldridge
authors: Claire M
authors: CM
authors: Noell
authors: Andrew A
authors: AA
authors: Dorosario
authors: Jorgen L
authors: JL
authors: Hansen
authors: Thomas S
authors: TS
authors: Kupper
authors: Phillip M
authors: PM
authors: Devlin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000209:etiology; D005153:Facial Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012878:Skin Neoplasms / Q000532:radiotherapy*; D016896:Treatment Outcome