title: Role of gluten intake at the time of hepatitis B virus vaccination in the immune response of celiac patients.
abstract: Some reports have demonstrated an inadequate response to hepatitis B vaccination in patients affected by celiac disease. The aim of our study was to evaluate hepatitis B vaccination response in relation to gluten exposure status in patients with celiac disease. To measure the gluten exposure status at the time of vaccination, we considered three groups: group A (exposed to gluten), including patients vaccinated as 12-year-old adolescents (the celiac disease diagnosis was established after vaccination); group B (not exposed to gluten), including patients vaccinated as 12-year-old adolescents on a gluten-free diet at the time of vaccination; and group C (infants), including patients vaccinated at birth. The response of celiac patients to hepatitis B vaccination was compared to that of healthy subjects, i.e., those in the control group (group D). This study included 163 celiac patients (group A, 57 patients; group B, 46 patients; and group C, 60 patients) and 48 controls (group D). An inadequate response to hepatitis B immunization was present in 43.9% of patients in group A, 34.8% of patients in group B, 58.3% of patients in group C, and 8.3% of patients in group D (group A versus group D, P < 0.001; group B versus group D, P = 0.002; group C versus group D, P = 0.001) (no significant difference for group A versus group B and group A versus group C was evident). Our data suggest that gluten exposure does not influence the response to hepatitis B immunization and that the human leukocyte antigen probably plays the main immunological role in poor responses to hepatitis B-vaccinated celiac patients.
authors: Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
authors: F
authors: F
authors: Zingone
authors: P
authors: P
authors: Capone
authors: R
authors: R
authors: Tortora
authors: A
authors: A
authors: Rispo
authors: F
authors: F
authors: Morisco
authors: N
authors: N
authors: Caporaso
authors: N
authors: N
authors: Imperatore
authors: G
authors: G
authors: De Stefano
authors: P
authors: P
authors: Iovino
authors: C
authors: C
authors: Ciacci
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000276:immunology*; D055050:Diet, Gluten-Free; D005260:Female; D005983:Glutens / Q000008:administration & dosage*; D006680:HLA Antigens / Q000276:immunology; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D014611:Vaccination
chemical_list: D006680:HLA Antigens; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D005983:Glutens