title: Opioid receptor interacting proteins and the control of opioid signaling.
abstract: Opioid receptors are seven-transmembrane domain receptors that couple to intracellular signaling molecules by activating heterotrimeric G proteins. However, the receptor and G protein do not function in isolation but their activities are modulated by several accessory and scaffolding proteins. Examples include arrestins, kinases, and regulators of G protein signaling proteins. Accessory proteins contribute to the observed potency and efficacy of agonists, but also to the direction of signaling and the phenomenon of biased agonism. This review will present current knowledge of such proteins and how they may provide targets for future drug design.
authors: Jennifer T
authors: JT
authors: Lamberts
authors: Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5632, USA. jtraynor@umich.edu.
authors: John R
authors: JR
authors: Traynor
mesh_terms: D000818:Animals; D006801:Humans; D018847:Opioid Peptides / Q000378:metabolism*; D020710:RGS Proteins / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018847:Opioid Peptides; D020710:RGS Proteins; D011957:Receptors, Opioid