title: Solving the challenges of large multicenter trials in anesthesia.
abstract: This paper describes many of the challenges encountered when establishing a large multicentre trial in cardiac anesthesia. We address funding, authorship, multisite ethics review, patient recruitment, data quality management, communication with individual sites, and strategies to enhance cooperation and patient recruitment.
authors: Department of Anaesthesia and Perioperative Medicine, Alfred Hospital; Melbourne, Australia.
authors: S
authors: S
authors: Wallace
authors: P S
authors: PS
authors: Myles
keywords: anesthesia; cardiac anesthesia; methodology; multicenter trials