title: Taxifolin Glycoside Blocks Human ether-a-go-go Related Gene K(+) Channels.
abstract: Taxifolin glycoside is a new drug candidate for the treatment of atopic dermatitis (AD). Many drugs cause side effects such as long QT syndrome by blocking the human ether-a-go-go related gene (hERG) K(+) channels. To determine whether taxifolin glycoside would block hERG K(+) channels, we recorded hERG K(+) currents using a whole-cell patch clamp technique. We found that taxifolin glycoside directly blocked hERG K(+) current in a concentration-dependent manner (EC(50)=9.6±0.7 µM). The activation curve of hERG K(+) channels was negatively shifted by taxifolin glycoside. In addition, taxifolin glycoside accelerated the activation time constant and reduced the onset of the inactivation time constant. These results suggest that taxifolin glycoside blocks hERG K(+) channels that function by facilitating activation and inactivation process.
authors: Department of Physiology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
authors: Jihyun
authors: J
authors: Yun
authors: Hyemi
authors: H
authors: Bae
authors: Sun Eun
authors: SE
authors: Choi
authors: Jung-Ha
authors: JH
authors: Kim
authors: Young Wook
authors: YW
authors: Choi
authors: Inja
authors: I
authors: Lim
authors: Chung Soo
authors: CS
authors: Lee
authors: Min Won
authors: MW
authors: Lee
authors: Jae-Hong
authors: JH
authors: Ko
authors: Seong Jun
authors: SJ
authors: Seo
authors: Hyoweon
authors: H
authors: Bang
keywords: Long QT syndrome; Patch clamp; Taxifolin glycoside; hERG K channel