title: Correlations between the time-intensity parameters of contrast-enhanced ultrasound and clinical prognosis of hepatocellular carcinoma.
abstract: OBJECTIVE
  The purpose of the study was to detect the correlation between the time-intensity parameters of contrast-enhanced ultrasound (CEUS) and the clinical prognosis of hepatocellular carcinoma (HCC).
  
  
  METHODS
  A total of 73 HCC patients were analyzed with the time-intensity curve of CEUS. The expression of vascular endothelial factor (VEGF) and CD34 in different differentiation-staged HCC specimens was observed using immunohistochemistry.
  
  
  RESULTS
  A positive correlation was found between the VEGF expression and microvessel density. The time-intensity parameters were not correlated with the HCC size.
  
  
  CONCLUSIONS
  CEUS time-intensity parameters are inducive for assessing the prognosis of HCC with revealed intratumoral microvessel perfusion in different differentiation stages.
authors: Department of Ultrasound, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China. yilinyangcn@126.com
authors: Yi-Lin
authors: YL
authors: Yang
authors: Rui-Jing
authors: RJ
authors: Yang
authors: Xi
authors: X
authors: Liu
authors: Jie
authors: J
authors: Liu
authors: Li-Juan
authors: LJ
authors: Chao
authors: Yun-You
authors: YY
authors: Duan
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging*; D016009:Chi-Square Distribution; D003287:Contrast Media; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D014463:Ultrasonography; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D003287:Contrast Media; D042461:Vascular Endothelial Growth Factor A