title: [Urothelial carcinoma in patients under 40 years. Review of the cancer committee of the French Association of Urology].
abstract: BACKGROUND
  Urothelial carcinoma in young patients (<40 years) is rare. The only known risk factor is exposure to tobacco smoking and/or early active tobacco intoxication. No genetic predisposing factor seems to exist.
  
  
  METHODS
  A review of the literature was performed using PubMed database with a combination of the following keywords: urothelial carcinoma, young patients/adults, children, pediatrics, urothelium and neoplasm prognosis.
  
  
  CONCLUSIONS
  Urothelial carcinomas before the age of 20 years are non-invasive papillary lesions (papillary urothelial neoplasm of low malignant potential and non-invasive papillary urothelial carcinoma low grade or high grade) of excellent prognosis. Rare cases of infiltrating carcinomas have been described between 20 to 40 years; their histological and clinical aspects are close to those observed in usual urothelial carcinomas.
  
  
  CONCLUSIONS
  The management of urothelial carcinomas of patients under 40 years relies on the tumor grade and stage. Treatment of aggressive cases has to be curative from a clinical point of view, nevertheless conserving vital and reproducing functions.
authors: Service d'anatomie pathologique, université Pierre-et-Marie-Curie, groupe hospitalier Pitié-Salpêtrière Paris VI, 47-83, boulevard de l'Hôpital, 75013 Paris, France. evacomperat@yahoo.fr
authors: E
authors: E
authors: Compérat
authors: P
authors: P
authors: Camparo
authors: S
authors: S
authors: Larré
authors: M
authors: M
authors: Roupret
authors: Y
authors: Y
authors: Neuzillet
authors: G
authors: G
authors: Pignot
authors: H
authors: H
authors: Quintens
authors: N
authors: N
authors: Houéde
authors: C
authors: C
authors: Roy
authors: M
authors: M
authors: Soulié
authors: C
authors: C
authors: Pfister
mesh_terms: D000293:Adolescent; D000328:Adult; D002295:Carcinoma, Transitional Cell / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D015653:Cystectomy; D005602:France; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D012955:Societies, Medical; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D014572:Urology