title: Copper-catalyzed N-arylation of 2-imidazolines with aryl iodides.
abstract: The first copper-catalyzed N-arylation of 2-imidazolines is described. The reaction affords compounds with desirable lead-like characteristics in high yield with practical simplicity under inexpensive, "ligand-free" conditions. The cross coupling was successful with electron-rich and electron-poor aromatic iodides. Substrates bearing halides, esters, nitriles, and free hydroxyls are well tolerated, providing reactive handles for further functionalization, as are pyridines. In addition, the regioselective N-arylation of a 4-substituted imidazoline is reported.
authors: Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK.
authors: Owen A
authors: OA
authors: Davis
authors: Matthew
authors: M
authors: Hughes
authors: James A
authors: JA
authors: Bull
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D048288:Imidazolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D006847:Hydrocarbons, Iodinated; D048288:Imidazolines; D003300:Copper