title: Protective effect of butylated hydroxytoluene on ferric nitrilotriacetate induced hepatotoxicity and oxidative stress in mice.
abstract: The present study was undertaken to evaluate the possible ameliorating effect of butylated hydroxyl toluene (BHT), associated with ferric nitrilotriacetate (Fe-NTA)-induced oxidative stress and liver injury in mice. The treatment of mice with Fe-NTA alone enhances ornithine decarboxylase activity to 4.6 folds, protein carbonyl formation increased up to 2.9 folds and DNA synthesis expressed in terms of [(3)H] thymidine incorporation increased to 3.2 folds, and antioxidants and antioxidant enzymes decreased to 1.8-2.5 folds, compared with the corresponding saline-treated controls. These changes were reversed significantly (p < 0.001) in animals receiving a pretreatment of BHT. Our data show that BHT can reciprocate the toxic effects of Fe-NTA and can serve as a potent chemopreventive agent.
authors: Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia. sansar@ksu.edu.sa
authors: S
authors: S
authors: Ansar
authors: H
authors: H
authors: Tabassum
authors: N
authors: N
authors: Al Jameil
mesh_terms: D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005290:Ferric Compounds / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D009955:Ornithine Decarboxylase / Q000096:biosynthesis; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation / Q000187:drug effects
chemical_list: D005290:Ferric Compounds; D002084:Butylated Hydroxytoluene; D009955:Ornithine Decarboxylase; D009571:Nitrilotriacetic Acid; C020326:ferric nitrilotriacetate
keywords: Ferric nitrilotriacetic acid; butylated hydroxyl toluene; hepatotoxicity; liver; oxidative stress