title: Role of acute phase proteins in the immune response of rabbits infected with Trypanosoma evansi.
abstract: The aim of this study was to characterize the response of acute phase proteins (APP) in rabbits experimentally infected with Trypanosoma evansi (T. evansi), and to relate the findings with serum immunoglobulins levels, in order to verify the relation between APP and the immune response of rabbits. A total of 12 animals were used in this experiment and divided into 2 groups, control and infected, of six rabbits each. The experimental period was 118 days, and blood was collected on days 0, 5, 20, 35, 65, 95 and 118 post-infection (PI). The infection with T. evansi stimulated APP and immunoglobulins production, once the infected animals showed an increase in C-reactive protein, haptoglobin, alpha 2-macroglobulin and IgM levels. The elevation in IgM levels observed in this study, when related to the increase in C-reactive protein and haptoglobin levels, suggests the involvement of these proteins in host defense against flagellated protozoa, with possible participation in the control of the parasitemia in rabbits infected with T. evansi.
authors: Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria - RS, Brazil. marmcvet@mail.ufsm.br
authors: Márcio Machado
authors: MM
authors: Costa
authors: Sonia Terezinha
authors: ST
authors: Dos Anjos Lopes
authors: Raqueli Teresinha
authors: RT
authors: França
authors: Aleksandro Schafer
authors: AS
authors: da Silva
authors: Francine Chimelo
authors: FC
authors: Paim
authors: Heloisa Einloft
authors: HE
authors: Palma
authors: Roberto Marinho
authors: RM
authors: Maciel
authors: Guilherme Lopes
authors: GL
authors: Dornelles
authors: Maria Isabel
authors: MI
authors: de Azevedo
authors: Alexandre Alberto
authors: AA
authors: Tonin
authors: Janio Morais
authors: JM
authors: Santurio
authors: Marta Maria Medeiros Frescura
authors: MM
authors: Duarte
authors: Silvia Gonzalez
authors: SG
authors: Monteiro
mesh_terms: D000209:Acute-Phase Proteins / Q000276:immunology*; D000818:Animals; D005260:Female; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology*; D018512:Parasitemia / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D011817:Rabbits / Q000276:immunology / Q000469:parasitology*; D018709:Statistics, Nonparametric; D014345:Trypanosoma / Q000276:immunology; D014352:Trypanosomiasis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*
chemical_list: D000209:Acute-Phase Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M