title: Development of quinoline-based disruptors of biofilm formation against Vibrio cholerae.
abstract: Biofilm formation is a major cause of bacterial persistence in nosocomial infections, leading to extended treatment times and increased rates of morbidity and mortality. Despite this, there are currently no biofilm inhibitors approved for clinical use. The synthesis and biological evaluation of a library of amino alcohol quinolines as lead compounds for the disruption of biofilm formation in Vibrio cholerae is now reported. Application of selective metal-halogen exchange chemistry installed both stereocenters in one step, to afford a simpler scaffold than the initial lead molecule, with an EC50 < 10 μM.
authors: Department of Chemistry and Biochemistry, University of California, Santa Cruz, 1156 High Street, Santa Cruz, California 95064, USA.
authors: Brian
authors: B
authors: León
authors: Jiunn C N
authors: JC
authors: Fong
authors: Kelly C
authors: KC
authors: Peach
authors: Weng Ruh
authors: WR
authors: Wong
authors: Fitnat H
authors: FH
authors: Yildiz
authors: Roger G
authors: RG
authors: Linington
mesh_terms: D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D020650:Combinatorial Chemistry Techniques; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D018613:Microscopy, Confocal; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D014734:Vibrio cholerae / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*
chemical_list: D011804:Quinolines