title: Deuterium depleted water effects on survival of lung cancer patients and expression of Kras, Bcl2, and Myc genes in mouse lung.
abstract: Although advances in cancer therapies continue to develop, the shortness of the survival of lung cancer patients is still disappointing. Therefore, finding new adjuvant strategies is within the focus of cancer cure. Based on observations that deuterium depletion inhibits the growth of cancer cell lines and suppresses certain proto-oncogenes, we have conducted a clinical study in 129 patients with small cell and nonsmall cell lung cancers who consumed deuterium-depleted drinking water (DDW) as a nontoxic agent in addition to conventional chemotherapy and radiotherapy. Median survival time (MST) was 25.9 mo in males and 74.1 mo in female patients; the difference between genders was statistically significant (p < 0.05). Median survival of subjects with brain metastasis was 27.1 mo. Cumulative 5-yr survival probabilities were 19%, 52%, and 33% in males, females, and all patients with brain metastasis, respectively. Gene expression analysis in mouse lung indicated that DDW attenuates 7,12-dimethylbenz(a)anthracene (DMBA)-induced expression of Bcl2, Kras, and Myc in females. In conclusion, DDW counteracts the DMBA-induced overexpression of Bcl2, Kras and Myc genes in mouse lung, and it may extend survival of lung cancer patients as a nontoxic anticancer dietary supplement, especially for women with tumors overexpressing cancer-related genes, because MST of DDW-consuming group was 2-4 times longer than it is generally observed in lung cancer patients.
authors: Department of Public Health, Medical School, University of Pécs, Pécs, Hungary. zoltan.gyongyi@aok.pte.hu
authors: Zoltán
authors: Z
authors: Gyöngyi
authors: Ferenc
authors: F
authors: Budán
authors: István
authors: I
authors: Szabó
authors: István
authors: I
authors: Ember
authors: István
authors: I
authors: Kiss
authors: Krisztina
authors: K
authors: Krempels
authors: Ildikó
authors: I
authors: Somlyai
authors: Gábor
authors: G
authors: Somlyai
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001932:Brain Neoplasms / Q000178:diet therapy / Q000473:pathology / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000178:diet therapy* / Q000401:mortality* / Q000473:pathology; D003903:Deuterium; D019587:Dietary Supplements; D060766:Drinking Water / Q000737:chemistry; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D019254:Genes, bcl-2; D016259:Genes, myc; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D008175:Lung Neoplasms / Q000178:diet therapy* / Q000401:mortality* / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008875:Middle Aged; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D055752:Small Cell Lung Carcinoma / Q000178:diet therapy* / Q000401:mortality* / Q000473:pathology; D014867:Water
chemical_list: D060766:Drinking Water; D014867:Water; D015127:9,10-Dimethyl-1,2-benzanthracene; D003903:Deuterium; C495971:Hras protein, mouse; D016283:Proto-Oncogene Proteins p21(ras)