title: Neuroprotective effects of salvianolic acid B on an Aβ25-35 peptide-induced mouse model of Alzheimer's disease.
abstract: Salvianolic acid B (SalB) is a polyphenolic compound found in Salvia miltiorrhiza Bunge that has several anti-oxidative and anti-inflammatory effects. In the present study, we investigated whether SalB has neuroprotective effects in an amyloid β (Aβ) peptide-induced Alzheimer's disease mouse model. Mice were injected with Aβ25-35 peptide intracerebroventricularly and were subsequently administered SalB once daily for 7 days. Subchronic SalB administration (10mg/kg) significantly ameliorated the Aβ25-35 peptide-induced memory impairment in the passive avoidance task (P<0.05). SalB treatment also reduced the number of activated microglia and astrocytes that were observed during the inflammatory reaction after the administration of the Aβ25-35 peptide. Moreover, SalB markedly reduced inducible nitric oxide synthase and cyclooxygenase-2 expression levels and thiobarbituric acid reactive substances, which were increased by the administration of the Aβ25-35 peptide. Furthermore, SalB administration significantly rescued the Aβ25-35 peptide-induced decrease of choline acetyltransferase and brain-derived neurotrophic factor protein levels. These results suggest that SalB exerts neuroprotective activity via anti-inflammatory and anti-oxidative effects and that SalB may be a potential candidate for Alzheimer's disease therapy.
authors: Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Young Woo
authors: YW
authors: Lee
authors: Dong Hyun
authors: DH
authors: Kim
authors: Su Jin
authors: SJ
authors: Jeon
authors: Se Jin
authors: SJ
authors: Park
authors: Jong Min
authors: JM
authors: Kim
authors: Jun Man
authors: JM
authors: Jung
authors: Hyung Eun
authors: HE
authors: Lee
authors: Shin Gil
authors: SG
authors: Bae
authors: Hee Kyong
authors: HK
authors: Oh
authors: Kun Ho
authors: KH
authors: Son
authors: Kun Ho
authors: KH
authors: Ho Son
authors: Jong Hoon
authors: JH
authors: Ryu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D016229:Amyloid beta-Peptides; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001572:Benzofurans / Q000494:pharmacology / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003072:Cognition Disorders / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004195:Disease Models, Animal; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010446:Peptide Fragments; D053630:Depsides
chemical_list: D016229:Amyloid beta-Peptides; D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D019208:Brain-Derived Neurotrophic Factor; D002795:Choline O-Acetyltransferase; D051546:Cyclooxygenase 2; D018696:Neuroprotective Agents; D052247:Nitric Oxide Synthase Type II; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35); C076944:salvianolic acid B; D053630:Depsides; C496317:Nos2 protein, mouse; C077623:Ptgs2 protein, mouse