title: Abnormal brain functional connectivity of the hypothalamus in cluster headaches.
abstract: The aim of this study was to detect the abnormality of the brain functional connectivity of the hypothalamus during acute spontaneous cluster headache (CH) attacks ('in attack') and headache-free intervals ('out of attack') using resting-state functional magnetic resonance imaging (RS-fMRI) technique. The RS-fMRI data from twelve male CH patients during 'in attack' and 'out of attack' periods and twelve age- and sex-matched normal controls were analyzed by the region-of-interest -based functional connectivity method using SPM5 software. Abnormal brain functional connectivity of the hypothalamus is present in CH, which is located mainly in the pain system during the spontaneous CH attacks. It extends beyond the pain system during CH attack intervals.
authors: Department of Neurology, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors: Enchao
authors: E
authors: Qiu
authors: Yan
authors: Y
authors: Wang
authors: Lin
authors: L
authors: Ma
authors: Lixia
authors: L
authors: Tian
authors: Ruozhuo
authors: R
authors: Liu
authors: Zhao
authors: Z
authors: Dong
authors: Xian
authors: X
authors: Xu
authors: Zhitong
authors: Z
authors: Zou
authors: Shengyuan
authors: S
authors: Yu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003027:Cluster Headache / Q000503:physiopathology*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D012146:Rest / Q000502:physiology; D055815:Young Adult