title: Three risk factors for WHO grade II and III meningiomas: A study of 1737 cases from a single center.
abstract: BACKGROUND
  Meningiomas account for 35.5% of central nervous system (CNS) tumors, of which 21-37.8% are atypical or anaplastic/malignant. High-grade meningiomas have higher rates of recurrence and worse outcome than grade I/II meningiomas. Thus, it is of importance to assess the tumor biology before treatment initiation.
  
  
  METHODS
  This study reviewed 1737 patients with histologically confirmed meningioma at a single institution. Meningiomas were classified according to World Health Organization (WHO) 2007 grading and the location of the tumor was confirmed from the operation records and preoperative imaging. Univariate and multivariate logistic regression were used to analyze the potential risk factors for high-grade pathology.
  
  
  RESULTS
  Young men and pediatric patients were less likely to have meningioma, but they had high-grade meningioma. Tumors originated from non-skull base and lateral intracranial are more likely to be grade II/III meningioma.
  
  
  CONCLUSIONS
  Lateral and non-skull base location, male sex, and the younger patients increase the risk for grade II and III pathology. These factors should be considered while deciding treatment choice, surgical resection, and prognosis as well.
authors: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Peizhi
authors: P
authors: Zhou
authors: Weichao
authors: W
authors: Ma
authors: Senlin
authors: S
authors: Yin
authors: Youping
authors: Y
authors: Li
authors: Shu
authors: S
authors: Jiang
mesh_terms: D006801:Humans; D008577:Meningeal Neoplasms; D008579:Meningioma / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012307:Risk Factors