title: Skin cancer associated with the use of sorafenib and sunitinib for renal cell carcinoma.
abstract: BACKGROUND
  Several case series have reported an association between sorafenib and the development of skin cancer, but they differ in the reported rapidity of skin cancer onset and the frequency of recurrence with ongoing multikinase inhibitor (MKI) treatment.
  
  
  OBJECTIVE
  To compare the presentation and incidence of skin cancer in patients with renal cell carcinoma (RCC) treated with sorafenib and sunitinib.
  
  
  METHODS
  This retrospective study reviewed the records of 69 patients with RCC treated with sorafenib or sunitinib at the University of Colorado Hospital between January 2005 and July 2009.
  
  
  RESULTS
  Seven patients treated with MKI developed skin cancer (5 (13.5%) with sorafenib, 2 (6.3%) with sunitinib; 5 squamous cell carcinomas (SCC), 3 basal cell carcinomas (BCC)); all developed in sun-exposed areas during first-line MKI therapy. The median time from the start of MKI therapy until observation of a skin cancer lesion was 13.5 months.
  
  
  CONCLUSIONS
  We observed more cases of skin cancer during sorafenib treatment than during sunitinib treatment for advanced RCC; median MKI treatment duration before the identification of skin cancer was longer than 1 year.
authors: Department of Medicine, School of Medicine, University of Colorado, Aurora, Colorado 80045, USA.
authors: Kathryn
authors: K
authors: Breaker
authors: Mary
authors: M
authors: Naam
authors: Francisco G
authors: FG
authors: La Rosa
authors: Insley P
authors: IP
authors: Flaig
authors: Thomas W
authors: TW
authors: Flaig
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002280:Basal Cell Carcinoma / Q000139:chemically induced* / Q000188:drug therapy; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D009536:Niacinamide / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010671:Phenylurea Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011758:Pyrroles / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced*; D000077157:Sorafenib; D000077210:Sunitinib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D011758:Pyrroles; D009536:Niacinamide; D000077157:Sorafenib; D000077210:Sunitinib