title: Genome-wide association study in Han Chinese identifies three novel loci for human height.
abstract: Human height is a complex genetic trait with high heritability but discovery efforts in Asian populations are limited. We carried out a meta-analysis of genome-wide association studies (GWAS) for height in 6,534 subjects with in silico replication of 1,881 subjects in Han Chinese. We identified three novel loci reaching the genome-wide significance threshold (P < 5 × 10(-8)), which mapped in or near ZNF638 (rs12612930, P = 2.02 × 10(-10)), MAML2 (rs11021504, P = 7.81 × 10(-9)), and C18orf12 (rs11082671, P = 1.87 × 10(-8)). We also confirmed two loci previously reported in European populations including CS (rs3816804, P = 2.63 × 10(-9)) and CYP19A1 (rs3751599, P = 4.80 × 10(-10)). In addition, we provided evidence supporting 35 SNPs identified by previous GWAS (P < 0.05). Our study provides new insights into the genetic determination of biological regulation of human height.
authors: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Yongchen
authors: Y
authors: Hao
authors: Xuehui
authors: X
authors: Liu
authors: Xiangfeng
authors: X
authors: Lu
authors: Xueli
authors: X
authors: Yang
authors: Laiyuan
authors: L
authors: Wang
authors: Shufeng
authors: S
authors: Chen
authors: Hongfan
authors: H
authors: Li
authors: Jianxin
authors: J
authors: Li
authors: Jie
authors: J
authors: Cao
authors: Jichun
authors: J
authors: Chen
authors: Ying
authors: Y
authors: Li
authors: Liancheng
authors: L
authors: Zhao
authors: Yongyong
authors: Y
authors: Shi
authors: Chong
authors: C
authors: Shen
authors: Weili
authors: W
authors: Yan
authors: Jiang
authors: J
authors: He
authors: Jianfeng
authors: J
authors: Huang
authors: Dongfeng
authors: D
authors: Gu
mesh_terms: D044466:Asian People; D001827:Body Height / Q000208:ethnology / Q000235:genetics*; D003198:Computer Simulation; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans