title: Total synthesis of 6-deoxyerythronolide B via C-C bond-forming transfer hydrogenation.
abstract: The 14-membered macrolide 6-deoxyerythronolide B is prepared in 14 steps (longest linear sequence) and 20 total steps. Two different methods for alcohol CH-crotylation via transfer hydrogenation are deployed for the first time in target-oriented synthesis. Enyne metathesis is used to form the 14-membered ring. The present approach represents the most concise construction of any erythronolide reported, to date.
authors: Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA.
authors: Xin
authors: X
authors: Gao
authors: Sang Kook
authors: SK
authors: Woo
authors: Michael J
authors: MJ
authors: Krische
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002384:Catalysis; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006865:Hydrogenation
chemical_list: D000438:Alcohols; D000900:Anti-Bacterial Agents; C034277:6-deoxyerythronolide B; D004917:Erythromycin