title: Human leukocyte antigen class I alleles and haplotypes associated with primary hepatocellular carcinoma in persistent HBV-infected patients.
abstract: Many studies have shown that Human leukocyte antigen (HLA) class I alleles are associated with the development of various cancers. However, its role in hepatocellular carcinoma (HCC) is still unknown. To investigate whether HLA class I allelic polymorphism is related to the development of hepatitis B virus(HBV)-associated HCC, a total of 326 HBV-infected patients (138 individuals with HCC and 188 well-matched controls without HCC) were enrolled in this study. HLA-A, -B, and -C were genotyped by polymerase chain reaction-sequencing based typing (PCR-SBT) method. We identified HLA-B(∗)35:01:01G as a risk factor for HBV-related HCC development independent of our previous findings in HLA region (OR, 12.04; p, 0.0028; pc, 0.04). HLA-A(∗)11:01:01G, B(∗)58:01:01G, C(∗)03:02:01G and some of their extended haplotypes were found as potential susceptible factors for HCC development. HLA-B(∗)46:01:01G and some of its extended haplotypes were found as potential protective factors for HCC development. Our results support that specific HLA class I alleles and haplotypes may affect the risk of HBV-related HCC development. The findings may help to determine better approaches for prevention and treatment of HCC in these patients.
authors: Department of Immunology and Pathogen Biology, Medical School, Southeast University, Nanjing 210009, China.
authors: Ning
authors: N
authors: Pan
authors: Keping
authors: K
authors: Chen
authors: Jie
authors: J
authors: Qiu
authors: Hang
authors: H
authors: Sun
authors: Jinhuan
authors: J
authors: Xu
authors: Fengqin
authors: F
authors: Miao
authors: Qian
authors: Q
authors: Shi
authors: Wei
authors: W
authors: Jiang
authors: Hui
authors: H
authors: Jin
authors: Youji
authors: Y
authors: He
authors: Wei
authors: W
authors: Xie
authors: Jianqiong
authors: J
authors: Zhang
mesh_terms: D000328:Adult; D000483:Alleles; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000150:complications*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000150:complications* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D015395:Histocompatibility Antigens Class I