title: Passive administration of purified secretory IgA from human colostrum induces protection against Mycobacterium tuberculosis in a murine model of progressive pulmonary infection.
abstract: BACKGROUND
  Immunoglobulin A is the most abundant isotype in secretions from mucosal surfaces of the gastrointestinal, respiratory and genitourinary tracts and in external secretions such as colostrum, breast milk, tears and saliva. The high concentration of human secretory IgA (hsIgA) in human colostrum strongly suggests that it should play an important role in the passive immune protection against gastrointestinal and respiratory infections.
  
  
  METHODS
  Human secretory IgA was purified from colostrum. The reactivity of hsIgA against mycobacterial antigens and its protective capacity against mycobacterial infection was evaluated.
  
  
  RESULTS
  The passive administration of hsIgA reduces the pneumonic area before challenge with M. tuberculosis. The intratracheal administration of M. tuberculosis preincubated with hsIgA to mice greatly reduced the bacterial load in the lungs and diminished lung tissue injury.
  
  
  CONCLUSIONS
  HsIgA purified from colostrum protects against M. tuberculosis infection in an experimental mouse model.
authors: Department of Molecular Biology, Finlay Institute, Center of Research - Producction of Vaccines, Ave. 27 No. 19805, La Lisa, Ciudad de Habana, Cuba, AP. 16017, CP 11600.
authors: Nadine
authors: N
authors: Alvarez
authors: Oscar
authors: O
authors: Otero
authors: Frank
authors: F
authors: Camacho
authors: Reinier
authors: R
authors: Borrero
authors: Yanely
authors: Y
authors: Tirado
authors: Alina
authors: A
authors: Puig
authors: Alicia
authors: A
authors: Aguilar
authors: Cesar
authors: C
authors: Rivas
authors: Axel
authors: A
authors: Cervantes
authors: Gustavo
authors: G
authors: Falero-Díaz
authors: Armando
authors: A
authors: Cádiz
authors: María E
authors: ME
authors: Sarmiento
authors: Mohd Nor
authors: MN
authors: Norazmi
authors: Rogelio
authors: R
authors: Hernández-Pando
authors: Armando
authors: A
authors: Acosta
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D058491:Bacterial Load; D003126:Colostrum / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007116:Immunization, Passive; D007071:Immunoglobulin A, Secretory / Q000008:administration & dosage* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000502:physiology; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000942:Antigens, Bacterial; D007071:Immunoglobulin A, Secretory