title: Visceral adiposity and risk of coronary heart disease in relatively lean Chinese adults.
abstract: BACKGROUND
  The hypertriglyceridemic waist phenotype (defined using both elevated waist circumference and triglycerides) and visceral adiposity index (VAI, defined using waist circumference, body mass index, triglycerides, and high-density lipoprotein cholesterol) have been suggested to be inexpensive yet effective markers of visceral (intra-abdominal) obesity and related dysmetabolic state. These markers may be particularly useful to Asian populations who generally have a low body weight but are prone to visceral adiposity.
  
  
  METHODS
  We examined associations of the hypertriglyceridemic waist phenotype and VAI with risk of coronary heart disease (CHD) in a nested case-control study conducted within two prospective cohort studies of Chinese adults. We identified 355 incident cases of CHD and 697 controls matched for sex, age, and date and time of baseline sample collection. Anthropometric and lipid measurements were performed and used to define the hypertriglyceridemic waist phenotype and VAI according to published methods. Conditional logistic regression was used to evaluate the associations.
  
  
  RESULTS
  Cases had a higher prevalence of the hypertriglyceridemic waist phenotype and higher VAI score than controls in both sexes. Adjusted odds ratios of CHD associated with hypertriglyceridemic waist were 5.18 (95% CI, 2.46-10.9) and 4.63 (2.03-10.5) for women and men, respectively. Adjusted odds ratios of CHD comparing the highest vs. lowest quartile of VAI were 4.44 (95% CI, 2.24-8.82) and 4.23 (1.99-9.00) for women and men, respectively.
  
  
  CONCLUSIONS
  Our study demonstrates, for the first time, that the hypertriglyceridemic waist phenotype and high VAI score are associated with substantially elevated risk of CHD in Chinese men and women.
authors: Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address: xianglan.zhang@vanderbilt.edu.
authors: Xianglan
authors: X
authors: Zhang
authors: Xiao-Ou
authors: XO
authors: Shu
authors: Honglan
authors: H
authors: Li
authors: Gong
authors: G
authors: Yang
authors: Yong-Bing
authors: YB
authors: Xiang
authors: Qiuyin
authors: Q
authors: Cai
authors: Bu-Tian
authors: BT
authors: Ji
authors: Yu-Tang
authors: YT
authors: Gao
authors: Wei
authors: W
authors: Zheng
mesh_terms: D050154:Adiposity; D000328:Adult; D000367:Age Factors; D000368:Aged; D002681:China / Q000453:epidemiology; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012737:Sex Factors; D013851:Thinness / Q000097:blood / Q000453:epidemiology*; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides
keywords: Chinese; Heart disease; Visceral adiposity