title: A catalyst-free, one-pot three-component aminomethylation of α-substituted nitroacetates: theoretical and experimental studies into the rate-accelerating effects of the solvent methanol.
abstract: 3, 2, 1 go! An unprecedented one-pot, catalyst-free, three-component aminomethylation of α-substituted nitroacetates, formalin, and amines has been reported, thereby enabling the highly efficient synthesis of α,β-diamino acid precursors with great structural diversity.
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China.
authors: Cong-Bin
authors: CB
authors: Ji
authors: Zhong-Yan
authors: ZY
authors: Cao
authors: Xin
authors: X
authors: Wang
authors: De-Yin
authors: DY
authors: Wu
authors: Jian
authors: J
authors: Zhou
mesh_terms: D000085:Acetates / Q000737:chemistry*; D002384:Catalysis; D006860:Hydrogen Bonding; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry*; D008745:Methylation; D008958:Models, Molecular; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry
chemical_list: D000085:Acetates; D048289:Imidazolidines; D012997:Solvents; C028257:nitroacetic acid; D000432:Methanol