title: Efficacy and toxicity of plerixafor for peripheral blood stem cell mobilization in children with high-risk neuroblastoma.
abstract: Six patients with high-risk neuroblastoma underwent the second stem cell collection round with G-CSF (5 μg/kg/day) + plerixafor (0.24 mg/kg/day) because the amount of CD34(+) cells collected during the first collection round with G-CSF alone was insufficient. The number of CD34(+) cells collected in the second collection round was higher in four patients and lower in two patients than in the first collection round. Four of the six patients experienced nightmares, nyctophobia, and visual hallucinations with G-CSF + plerixafor, which were not observed with G-CSF alone. Our findings suggest that plerixafor needs to be used with caution in children.
authors: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Meong Hi
authors: MH
authors: Son
authors: Eun Suk
authors: ES
authors: Kang
authors: Dong Hwan
authors: DH
authors: Kim
authors: Soo Hyun
authors: SH
authors: Lee
authors: Keon Hee
authors: KH
authors: Yoo
authors: Ki Woong
authors: KW
authors: Sung
authors: Hong Hoe
authors: HH
authors: Koo
authors: Dae Won
authors: DW
authors: Kim
authors: Ju Youn
authors: JY
authors: Kim
authors: Eun Joo
authors: EJ
authors: Cho
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001596:Benzylamines; D000080027:Cyclams; D004325:Dreams / Q000187:drug effects*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects; D006212:Hallucinations / Q000139:chemically induced*; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects* / Q000379:methods; D006412:Hematopoietic Stem Cells; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009447:Neuroblastoma
chemical_list: D019380:Anti-HIV Agents; D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor