title: Simultaneous measurement of deep tissue blood flow and oxygenation using noncontact diffuse correlation spectroscopy flow-oximeter.
abstract: We report a novel noncontact diffuse correlation spectroscopy flow-oximeter for simultaneous quantification of relative changes in tissue blood flow (rBF) and oxygenation (Δ[oxygenation]). The noncontact probe was compared against a contact probe in tissue-like phantoms and forearm muscles (n = 10), and the dynamic trends in both rBF and Δ[oxygenation] were found to be highly correlated. However, the magnitudes of Δ[oxygenation] measured by the two probes were significantly different. Monte Carlo simulations and phantom experiments revealed that the arm curvature resulted in a significant underestimation (~-20%) for the noncontact measurements in Δ[oxygenation], but not in rBF. Other factors that may cause the residual discrepancies between the contact and noncontact measurements were discussed, and further comparisons with other established technologies are needed to identify/quantify these factors. Our research paves the way for noncontact and simultaneous monitoring of blood flow and oxygenation in soft and vulnerable tissues without distorting tissue hemodynamics.
authors: Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506-0070, USA.
authors: Ting
authors: T
authors: Li
authors: Yu
authors: Y
authors: Lin
authors: Yu
authors: Y
authors: Shang
authors: Lian
authors: L
authors: He
authors: Chong
authors: C
authors: Huang
authors: Margaret
authors: M
authors: Szabunio
authors: Guoqiang
authors: G
authors: Yu
mesh_terms: D001783:Blood Flow Velocity; D005542:Forearm / Q000098:blood supply*; D006439:Hemodynamics; D006801:Humans; D018482:Muscle, Skeletal / Q000098:blood supply*; D010092:Oximetry / Q000295:instrumentation / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D012039:Regional Blood Flow; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods
chemical_list: D010100:Oxygen