title: Polymerization of a peptide-based enzyme substrate.
abstract: Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates.
authors: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
authors: Michael E
authors: ME
authors: Hahn
authors: Lyndsay M
authors: LM
authors: Randolph
authors: Lisa
authors: L
authors: Adamiak
authors: Matthew P
authors: MP
authors: Thompson
authors: Nathan C
authors: NC
authors: Gianneschi
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism*; D058105:Polymerization; D059748:Proteolysis
chemical_list: D004798:Enzymes; D009842:Oligopeptides