title: [Genome-wide linkage scan for an ethnic Han Chinese pedigree affected with schizophrenia].
abstract: OBJECTIVE
  To perform genome-wide linkage analysis for an ethnic Han Chinese pedigree with schizophrenia in order to locate the susceptibility genes.
  
  
  METHODS
  Genomic DNA was extracted from 4 mL of peripheral blood using conventional phenol-chloroform method. Illumina Infinium Linkage 24 BeadChips chip was used for determining the genotypes through detection of single nucleotide polymorphisms (SNPs). After processing the raw data using Illumina BeadStudio software, two-point nonparametric linkage analysis and two-point parametric linkage analysis were performed with Merlin software.
  
  
  RESULTS
  By two-point nonparametric linkage analysis, 27 sites with high LOD scores (LOD=0.63-0.75, P U+003C 0.05) were identified. Among these, 3 SNPs(rs993694, rs992690 rs1861577) were located in 12p12.3 region, whilst the remainders were located in 4p12-q22 region. Two-point parametric linkage analysis under a dominant model has yielded almost identical results.
  
  
  CONCLUSIONS
  Chromosomal regions 4p12-q22 and 12p12.3 probably contain susceptibility genes for schizophrenia.
authors: Department of Psychiatry, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors: Lian-sheng
authors: LS
authors: Zhao
authors: Ying-cheng
authors: YC
authors: Wang
authors: Jin-xue
authors: JX
authors: Wei
authors: Xiang
authors: X
authors: Liu
authors: Zhen-xing
authors: ZX
authors: Yang
authors: Tao
authors: T
authors: Li
authors: Xiao-gang
authors: XG
authors: Chen
authors: Xiao-hong
authors: XH
authors: Ma
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D002881:Chromosomes, Human, Pair 12; D002894:Chromosomes, Human, Pair 4; D005260:Female; D008040:Genetic Linkage; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*