title: [Association between ESR1 gene polymorphisms and haplotypes with schizophrenia].
abstract: OBJECTIVE
  To assess the association between single nucleotide polymorphisms (SNPs) and haplotypes of estrogen receptor 1 (ESR1) gene with schizophrenia.
  
  
  METHODS
  Three SNPs (rs2234693, rs9340799 and rs3798759) were determined in 333 schizophrenic patients and 315 healthy subjects with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Allelic and genotypic frequencies and particular haplotypes were compared between the two groups using Chi-square test.
  
  
  RESULTS
  The allelic and genotypic frequencies of rs2234693 and rs9340799 showed no significant difference between the two groups (P U+003E 0.05). However, a significant difference was detected in the frequencies of rs3798759 G allele and GG genotype between the two groups (P U+003C 0.01). Single factor analysis stratified by sex also found that frequencies of rs3798759 GG and TG genotypes and G allele were significantly higher in female schizophrenia patients compared with healthy females (P U+003C 0.05). Haplotypes C-A-G and C-G-G were more common in schizophrenia group (P U+003C 0.05).
  
  
  CONCLUSIONS
  polymorphisms of rs3798759 may be a risk factor for female patients with schizophrenia, and haplotypes C-A-G and C-G-G may be risk factors for schizophrenia.
authors: Department of Cell Biology and Medical Genetics, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors: Li-wen
authors: LW
authors: Wang
authors: Shu-ping
authors: SP
authors: He
authors: Jing-liang
authors: JL
authors: Zhang
authors: Dong-xiao
authors: DX
authors: Tong
authors: Ying
authors: Y
authors: He
authors: Xiao-li
authors: XL
authors: Cheng
mesh_terms: D000328:Adult; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D012737:Sex Factors
chemical_list: D047628:Estrogen Receptor alpha