title: Long-term physico-chemical stability of diluted trastuzumab.
abstract: Using several complementary analytical methods, we demonstrated that the monoclonal antibody Trastuzumab (Tz), diluted in 0.9% sodium chloride can be stored in polyolefin infusion bags at 4°C or room temperature up to 6 months with no evidence of chemical or physical instability. No aggregation of Tz was observed and its three dimensional structure remains unaltered. Thus, the practical use of diluted Tz can be safely extended to optimize the workload of centralized preparation units and to minimize costs.
authors: Department of Pharmacy, Henri Mondor Hospital Group, Créteil, France. muriel.paul@hmn.aphp.fr
authors: Muriel
authors: M
authors: Paul
authors: Victoire
authors: V
authors: Vieillard
authors: Ricardo
authors: R
authors: Da Silva Lemos
authors: Laurence
authors: L
authors: Escalup
authors: Alain
authors: A
authors: Astier
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D004349:Drug Packaging; D004355:Drug Stability; D004356:Drug Storage; D011090:Polyenes; D013696:Temperature; D000068878:Trastuzumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D011090:Polyenes; C035051:PL 732; D000068878:Trastuzumab