title: Effects of dietary magnesium on testicular histology, steroidogenesis, spermatogenesis and oxidative stress markers in adult rats.
abstract: The available information on the effect of excess dietary magnesium on male reproduction is inadequate, though consumption of hard water rich in magnesium salt is not uncommon in many geographical areas. The present study has thus been undertaken to evaluate the morphological as well as cytological and functional changes in testis of magnesium administered sexually mature male Wistar rats. Significant increase in the activities of androgenic enzymes viz. delta(5)3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase with concomitant increase in serum testosterone level, followed by progressive development in cytoarchitechture of genital organs, without any significant alteration in quantitative spermatogenesis were observed. The results were more marked in the groups treated for longer duration. The results further suggests that the changes that occurred after excessive magnesium in testis were not for the enhanced adrenocortical activities or for the generation of oxidative stress in reproductive organs, but for the direct action of excess magnesium on male gonads. Magnesium supplementation thus has an apparent beneficial effect on male gonadal system.
authors: Endocrinology & Reproductive Physiology Laboratory, Department of Physiology, University of Calcutta, Kolkata 700 009, India. physiology.ac@gmail.com
authors: Amar K
authors: AK
authors: Chandra
authors: Pallav
authors: P
authors: Sengupta
authors: Haimanti
authors: H
authors: Goswami
authors: Mahitosh
authors: M
authors: Sarkar
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004032:Diet; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005247:Feeding Behavior; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D015227:Lipid Peroxidation; D007986:Luteinizing Hormone / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D018384:Oxidative Stress; D011863:Radioimmunoassay / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D013050:Spectrometry, Fluorescence / Q000379:methods; D013091:Spermatogenesis / Q000187:drug effects*; D013256:Steroids / Q000378:metabolism*; D013737:Testis / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D013256:Steroids; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D015067:17-Hydroxysteroid Dehydrogenases; D015096:3-Hydroxysteroid Dehydrogenases; C031954:delta(5)-3 beta-hydroxysteroid dehydrogenase; C044256:3 (or 17)-beta-hydroxysteroid dehydrogenase; D008274:Magnesium