title: Human granulocytic Anaplasmosis, Japan.
abstract: We retrospectively confirmed 2 cases of human Anaplasma phagocytophilum infection. Patient blood samples contained unique p44/msp2 for the pathogen, and antibodies bound to A. phagocytophilum antigens propagated in THP-1 rather than HL60 cells. Unless both cell lines are used for serodiagnosis of rickettsiosis-like infections, cases of human granulocytic anaplasmosis could go undetected.
authors: University of Shizuoka and Global Center of Excellence Program, Shizuoka City, Japan. ohashi@u-shizuoka-ken.ac.jp
authors: Norio
authors: N
authors: Ohashi
authors: Gaowa
authors: Wuritu
authors: Fumihiko
authors: F
authors: Kawamori
authors: Dongxing
authors: D
authors: Wu
authors: Yuko
authors: Y
authors: Yoshikawa
authors: Seizou
authors: S
authors: Chiya
authors: Kazutoshi
authors: K
authors: Fukunaga
authors: Toyohiko
authors: T
authors: Funato
authors: Masaaki
authors: M
authors: Shiojiri
authors: Hideki
authors: H
authors: Nakajima
authors: Yoshiji
authors: Y
authors: Hamauzu
authors: Ai
authors: A
authors: Takano
authors: Hiroki
authors: H
authors: Kawabata
authors: Shuji
authors: S
authors: Ando
authors: Toshio
authors: T
authors: Kishimoto
mesh_terms: D000368:Aged; D041081:Anaplasma phagocytophilum / Q000235:genetics*; D000712:Anaplasmosis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D000907:Antibodies, Bacterial / Q000097:blood; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D004269:DNA, Bacterial / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D016873:Ehrlichiosis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D005798:Genes, Bacterial; D018922:HL-60 Cells; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D058889:Molecular Typing; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012189:Retrospective Studies; D012698:Serologic Tests
chemical_list: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S