title: [A study of interleukin-10 gene polymorphisms in Miao, Dong and Buyi ethnics of Guizhou].
abstract: OBJECTIVE
  To investigate allelic frequencies of interluekin-10 (IL-10) gene promoter in Miao, Dong and Buyi ethnics of Guizhou.
  
  
  METHODS
  TaqMan MGB-based real-time PCR was used to determine the genotypes of IL-10 -819 and IL-10 -592 in 589 Miao, Dong and Buyi ethnics of Guizhou.
  
  
  RESULTS
  The allelic frequency of IL-10 -819 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. Allelic frequencies of IL-10 -592 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. In Miao, Dong and Buyi ethnics, the distributions of genotype frequencies of IL-10 -819 and IL-10 -592 were statistically different from Han ethnics from Guizhou and Taiwan of China as well as South Koreans.
  
  
  CONCLUSIONS
  There is a heterogeneity in the frequencies of polymorphisms of IL-10 promoter among different ethnic groups.
authors: Guiyang Medical University, Guizhou, Guiyang, People's Republic of China.
authors: Chan-juan
authors: CJ
authors: Wang
authors: Ke-ren
authors: KR
authors: Shan
authors: Yan
authors: Y
authors: He
authors: Ting
authors: T
authors: Zhang
authors: Yi
authors: Y
authors: Li
authors: Chang-xue
authors: CX
authors: Wu
authors: Chan
authors: C
authors: Zhang
authors: Zhi-zhong
authors: ZZ
authors: Guan
mesh_terms: D000483:Alleles; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D002681:China / Q000208:ethnology; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups / Q000235:genetics; D011401:Promoter Regions, Genetic
chemical_list: D016753:Interleukin-10