title: Pd-catalyzed tandem sp2-sp3 coupling reactions of chiral stannolanes: an efficient preparation of optically active tetrahydrobenz[f]isoindoles.
abstract: A novel double Migita-Kosugi-Stille coupling reaction with dihydrostannolanes, which are readily available from a radical cascade reaction, was achieved with dihalobenzenes in the presence of a palladium catalyst. Use of unsymmetrical 1-bromo-2-iodobenzene derivatives accomplished the double coupling reaction which gave tetrahydrobenz[f]isoindoles in a regioselective manner.
authors: Department of Applied Molecular Bioscience, Yamaguchi University, Ube, 755-8611, Japan. ak10@yamaguchi-u.ac.jp
authors: Akio
authors: A
authors: Kamimura
authors: Masahiro
authors: M
authors: So
authors: Shingo
authors: S
authors: Ishikawa
authors: Hidemitsu
authors: H
authors: Uno
mesh_terms: D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry; D006847:Hydrocarbons, Iodinated / Q000737:chemistry; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009947:Organotin Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006842:Hydrocarbons, Brominated; D006847:Hydrocarbons, Iodinated; D054833:Isoindoles; D009947:Organotin Compounds; D010165:Palladium