title: Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture.
abstract: Peripheral lymphoid tissues, such as lymph nodes and Peyer's patches (PPs), are organs required for mounting highly efficient immune responses to small quantities of Ag. The compartmentalization of the cellular components involved in the immune response into distinct zones supports the function of these tissues; however, little is known about how this compartmentalization is achieved. In this study, we analyzed neonatal PP development and present evidence that the CD3(-)IL-7Rα(+) PP inducer cells that initially play a pivotal role in the formation of the PP anlagen are involved in the formation of B and T cell zones in neonatal mice. PP inducer cells migrate between these zones by undergoing chemokine receptor switching.
authors: Center for Developmental Biology, RIKEN, Kobe 650-0047, Japan.
authors: Reiko
authors: R
authors: Nakagawa
authors: Atsushi
authors: A
authors: Togawa
authors: Takashi
authors: T
authors: Nagasawa
authors: Shin-ichi
authors: S
authors: Nishikawa
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D002465:Cell Movement / Q000276:immunology; D005260:Female; D008297:Male; D051379:Mice; D010581:Peyer's Patches / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D019707:Receptors, Chemokine / Q000378:metabolism; D020395:Receptors, Interleukin-7 / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D013997:Time Factors
chemical_list: D019707:Receptors, Chemokine; D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain