title: In vitro evolution of a Friedel-Crafts deoxyribozyme.
abstract: We report the in vitro selection of a single-stranded 72-nucleotide DNA enzyme (deoxyribozyme) that catalyzes a Friedel-Crafts reaction between an indole and acyl imidazole in good yield and in aqueous solvent. Appreciable Friedel-Crafts product requires addition of copper nitrate and the deoxyribozyme. We observe deoxyribozyme-mediated bond formation for both in cis and in trans Friedel-Crafts reactions.
authors: Department of Chemistry, Colorado State University, 200 West Lake Street, Fort Collins, CO, USA.
authors: Utpal
authors: U
authors: Mohan
authors: Ritwik
authors: R
authors: Burai
authors: Brian R
authors: BR
authors: McNaughton
mesh_terms: D003300:Copper / Q000737:chemistry*; D021881:DNA, Catalytic / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009566:Nitrates / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D021881:DNA, Catalytic; D007093:Imidazoles; D007211:Indoles; D009566:Nitrates; D014867:Water; D003300:Copper; C516433:copper(II) nitrate