title: A one-two punch of miR-126/126* against metastasis.
abstract: MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.
authors: Department of Molecular Biology, LTL255, Washington Road, Princeton University, Princeton, New Jersey 08544, USA.
authors: Guangwen
authors: G
authors: Ren
authors: Yibin
authors: Y
authors: Kang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008175:Lung Neoplasms / Q000517:prevention & control*; D059630:Mesenchymal Stem Cells / Q000473:pathology*; D035683:MicroRNAs / Q000235:genetics*; D009000:Monocytes / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology*
chemical_list: C527111:MIRN126 microRNA, human; C545201:MIRN126 microRNA, mouse; D035683:MicroRNAs