title: Serum concentration of IL-17, IL-23 and TNF-α among patients with chronic spontaneous urticaria: association with disease activity and autologous serum skin test.
abstract: BACKGROUND
  Chronic spontaneous urticaria (CSU) is a common skin disorder, which is considered in a subset of patients to be an autoimmune disorder. T helper 17 (Th17) cells are crucially involved in the pathogenesis of some autoimmune diseases.
  
  
  OBJECTIVE
  Our aim was to test the association of Th17 with CSU. We examined interleukin (IL)-17, IL-23 and tumor necrosis factor-alpha (TNF-α) serum levels in CSU patients and studied their association with urticaria activity and autologous serum skin test (ASST).
  
  
  METHODS
  Serum concentration of IL-17, IL-23 and TNF-α were measured in 75 patients with CSU and 30 healthy control subjects. Disease activity was assessed by using urticaria activity score (UAS) as recommended by EAACI/GA(2)LEN/EDF/WAO Guidelines.
  
  
  RESULTS
  Serum concentration of IL-17, IL-23 and TNF-α were significantly higher in CSU patients as compared with the healthy control subjects (mean: 35.51 ± 31.14 vs. 4.60 ± 1.38 pg/mL; P < 0.001, 38.95 ± 27.82 vs. 9.87 ± 4.62 pg/mL; P > 0.001 and 17.93 ± 6.05 vs. 6.87 ± 3.73 pg/mL; P = 0.004, respectively). There were significant positive correlation between serum IL-17, IL-23, TNF-α and disease activity assessed by cumulative UAS for 7 days before blood sampling. The Serum concentration of IL-17, IL-23 and TNF-α were also significantly higher in ASST positive patients than in ASST negative patients.
  
  
  CONCLUSIONS
  Our results showed high serum levels of IL-17, IL-23 and TNF-α among CSU patients which may highlight a functional role of these cytokines in the pathogenesis of this important and common skin disease. It also may provide the rationale for new treatment strategies in chronic urticaria.
authors: Dermatology & Venereology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
authors: M A
authors: MA
authors: Atwa
authors: A S
authors: AS
authors: Emara
authors: N
authors: N
authors: Youssef
authors: N M
authors: NM
authors: Bayoumy
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D053759:Interleukin-23 / Q000097:blood*; D012882:Skin Tests / Q000379:methods*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D014581:Urticaria / Q000097:blood*
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23; D014409:Tumor Necrosis Factor-alpha