title: Building biologics by chemical synthesis: practical preparation of di- and triantennary N-linked glycoconjugates.
abstract: A unified strategy for the syntheses of bi- and triantennary fully sialylated N-glycans is described. The synthesis capitalizes on a global glycosylation strategy that delivers the desired undeca- and tetradecasaccharide in excellent yields. Finally, conjugation of the glycan to PSMA oligopeptide is described.
authors: Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.
authors: Maciej A
authors: MA
authors: Walczak
authors: Joji
authors: J
authors: Hayashida
authors: Samuel J
authors: SJ
authors: Danishefsky
mesh_terms: D000595:Amino Acid Sequence; D000954:Antigens, Surface / Q000737:chemistry*; D043425:Glutamate Carboxypeptidase II / Q000138:chemical synthesis / Q000737:chemistry*; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000954:Antigens, Surface; D006001:Glycoconjugates; D009842:Oligopeptides; D011134:Polysaccharides; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II