title: Advances in targeting signal transduction pathways.
abstract: Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target key components in those pathways. Furthermore critical information is being accrued regarding how genetic mutations can affect the sensitivity of various types of patients to targeted therapy. Finally, genetic mechanisms responsible for the development of resistance after targeted therapy are being discovered which may allow the creation of alternative therapies to overcome resistance. This review will discuss some of the highlights over the past few years on the roles of key signaling pathways in various diseases, the targeting of signal transduction pathways and the genetic mechanisms governing sensitivity and resistance to targeted therapies.
authors: Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, USA. mccubreyj@ecu.edu
authors: James A
authors: JA
authors: McCubrey
authors: Linda S
authors: LS
authors: Steelman
authors: William H
authors: WH
authors: Chappell
authors: Lin
authors: L
authors: Sun
authors: Nicole M
authors: NM
authors: Davis
authors: Stephen L
authors: SL
authors: Abrams
authors: Richard A
authors: RA
authors: Franklin
authors: Lucio
authors: L
authors: Cocco
authors: Camilla
authors: C
authors: Evangelisti
authors: Francesca
authors: F
authors: Chiarini
authors: Alberto M
authors: AM
authors: Martelli
authors: Massimo
authors: M
authors: Libra
authors: Saverio
authors: S
authors: Candido
authors: Giovanni
authors: G
authors: Ligresti
authors: Grazia
authors: G
authors: Malaponte
authors: Maria C
authors: MC
authors: Mazzarino
authors: Paolo
authors: P
authors: Fagone
authors: Marco
authors: M
authors: Donia
authors: Ferdinando
authors: F
authors: Nicoletti
authors: Jerry
authors: J
authors: Polesel
authors: Renato
authors: R
authors: Talamini
authors: Jörg
authors: J
authors: Bäsecke
authors: Sanja
authors: S
authors: Mijatovic
authors: Danijela
authors: D
authors: Maksimovic-Ivanic
authors: Michele
authors: M
authors: Michele
authors: Agostino
authors: A
authors: Tafuri
authors: Joanna
authors: J
authors: Dulińska-Litewka
authors: Piotr
authors: P
authors: Laidler
authors: Antonio B
authors: AB
authors: D'Assoro
authors: Lyudmyla
authors: L
authors: Drobot
authors: Drobot
authors: D
authors: Umezawa
authors: Giuseppe
authors: G
authors: Montalto
authors: Melchiorre
authors: M
authors: Cervello
authors: Zoya N
authors: ZN
authors: Demidenko
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D058990:Molecular Targeted Therapy; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors