title: The decrease in prolidase activity in myeloproliferative neoplasms.
abstract: BACKGROUND
  The development of bone marrow fibrosis is a severe complication in hematological diseases. The progress of bone marrow myelofibrosis is evaluated by a trephine examination and may be characterized by the biochemical markers of collagen turnover determination.
  
  
  OBJECTIVE
  Investigation of serum prolidase activity and biochemical markers of collagen metabolism in order to establish its role in the development of bone marrow fibrosis.
  
  
  METHODS
  The group of 37 patients with myeloproliferative neoplasms (MPN) before treatment, consisted of 16 patients with chronic myeloid leukemia (CML), 7 with primary myelofibrosis (PMF), 8 with essential thrombocythopenia (ET), and 6 with polycythemia vera (PV).
  
  
  RESULTS
  It was found that the plasma activity of prolidase (Pro) was reduced to almost half together with the serum level of osteocalcin (BGL), and hydroxyproline (H-PRO) in the serum and urine of patients with MPN in comparison to the control group. In the MPN group of patients, the levels of N-terminal procollagen III peptide (PIIINP), type I procollagen (PICP) and the C-terminal telopeptide of type I collagen (ICTP) were significantly higher.
  
  
  CONCLUSIONS
  The alteration of collagen turnover markers in the MPN patient group (the elevation of synthesis and inhibition of collagen catabolism rate) has suggested that a diminished prolidase activity may contribute to such alteration of collagen metabolism and should be consider a biomarker of MPN progress.
authors: Department of Medical Laboratory Diagnostics, Wroclaw Medical University, Poland. jnowicka3@gmail.com
authors: Jadwiga
authors: J
authors: Nowicka
authors: Wiesława
authors: W
authors: Nahaczewska
authors: Henryk
authors: H
authors: Owczarek
authors: Mieczysław
authors: M
authors: Woźniak
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D019046:Bone Marrow Neoplasms / Q000201:enzymology* / Q000503:physiopathology; D016723:Bone Remodeling; D016022:Case-Control Studies; D003238:Connective Tissue / Q000473:pathology / Q000503:physiopathology; D004150:Dipeptidases / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D004150:Dipeptidases; C022449:proline dipeptidase