title: Facile conversion of chromane-6-triflate to chromane-6-alanines under Palladium conditions.
abstract: Conversion of chromane-6-triflate5to chromane-6-dehydroalanine9or10via its Bpin-derivative6followed by Suzuki coupling with protected dehydroalanine bromides7or8were reported (86%). Alternatively, a palladium-catalyzed stannation of5with Bu6Sn2afforded the tributyltin derivative11, and iodination (12)followed by coupling with13gave chromane-6-alanine15(75%). Either approach constitutes a conversion from chromane-6-triflate to the corresponding protected chromane-6-alanine or its dehydro analog.
authors: Department of Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, Michigan, 48109.
authors: Daniel K
authors: DK
authors: Miller
keywords: Aryl Triflate; Boronation; Palladium-catalyzed coupling; Stannylation; Suzuki coupling