title: Evolving strategies in mechanobiology to more effectively treat damaged musculoskeletal tissues.
abstract: In this paper, we had four primary objectives. (1) We reviewed a brief history of the Lissner award and the individual for whom it is named, H.R. Lissner. We examined the type (musculoskeletal, cardiovascular, and other) and scale (organism to molecular) of research performed by prior Lissner awardees using a hierarchical paradigm adopted at the 2007 Biomechanics Summit of the US National Committee on Biomechanics. (2) We compared the research conducted by the Lissner award winners working in the musculoskeletal (MS) field with the evolution of our MS research and showed similar trends in scale over the past 35 years. (3) We discussed our evolving mechanobiology strategies for treating musculoskeletal injuries by accounting for clinical, biomechanical, and biological considerations. These strategies included studies to determine the function of the anterior cruciate ligament and its graft replacements as well as novel methods to enhance soft tissue healing using tissue engineering, functional tissue engineering, and, more recently, fundamental tissue engineering approaches. (4) We concluded with thoughts about future directions, suggesting grand challenges still facing bioengineers as well as the immense opportunities for young investigators working in musculoskeletal research. Hopefully, these retrospective and prospective analyses will be useful as the ASME Bioengineering Division charts future research directions.
authors: Tissue Engineering and Biomechanics Laboratories, Biomedical Engineering Program, College of Engineering and Applied Sciences, University of Cincinnati; Cincinnati, OH 45221, USA. david.butler@uc.edu
authors: David L
authors: DL
authors: Butler
authors: Nathaniel A
authors: NA
authors: Dyment
authors: Jason T
authors: JT
authors: Shearn
authors: Kirsten R C
authors: KR
authors: Kinneberg
authors: Andrew P
authors: AP
authors: Breidenbach
authors: Andrea L
authors: AL
authors: Lalley
authors: Steven D
authors: SD
authors: Gilday
authors: Cynthia
authors: C
authors: Gooch
authors: M B
authors: MB
authors: Rao
authors: Chia-feng
authors: CF
authors: Liu
authors: Christopher
authors: C
authors: Wylie
mesh_terms: D000818:Animals; D001363:Awards and Prizes; D001695:Biology / Q000379:methods*; D001696:Biomechanical Phenomena; D006801:Humans; D055595:Mechanical Phenomena; D009141:Musculoskeletal System / Q000293:injuries*; D062211:Spatio-Temporal Analysis