title: A four-component reaction involving in situ generated organometallic reagents: straightforward access to β-amino esters.
abstract: Four in one: A straightforward synthesis of β(2,3)-amino esters is described through a new zinc-mediated, cobalt-catalyzed four-component reaction between organic bromides, alkyl acrylates, amines, and aldehydes (see scheme). Synthesis involves a Mannich-related conjugate addition/aza-aldol domino sequence, allowing the formation of three single bonds in one step. A reaction mechanism, emphasizing the crucial role of zinc salts, is described.
authors: Electrochimie et Synthèse Organique, Institut de Chimie et des Matériaux Paris-Est, UMR 7182 CNRS-Université Paris-Est Créteil Val de Marne, 2-8 rue Henri Dunant, 94320 Thiais, France. legall@icmpe.cnrs.fr
authors: Erwan
authors: E
authors: Le Gall
authors: Eric
authors: E
authors: Léonel