title: The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels.
abstract: The objective of this study was to verify whether phenytoin modifies methylphenidate-induced hyperlocomotion, an animal model for screening antimanic-like drugs, and also evaluate the effect of veratrine, a voltage-gated sodium channel opener, pretreatment on the effect of phenytoin in this model. Carbamazepine was used as a positive control. Methylphenidate (5 mg/kg, s.c.) increased open-field locomotion, and phenytoin (5-10 mg/kg, i.p.) and carbamazepine (20 mg/kg, i.p.) blocked this effect. Veratrine (0.4 mg/kg, s.c.) pretreatment reversed the effects of phenytoin (10 mg/kg, i.p.) and carbamazepine (20 mg/kg, i.p.). Phenytoin (1-50 mg/kg, i.p.) and carbamazepine (10-20 mg/kg i.p.) alone did not change spontaneous locomotor activity. These results indicate that voltage-gated sodium channels play an important role in antimanic-like effects of phenytoin and carbamazepine on psychostimulant-induced hyperlocomotion model.
authors: Division of Biological Sciences, Department of Pharmacology, Universidade Federal do Paraná, Centro Politécnico C.P. 19031, Curitiba, Paraná, 81540-990, Brazil.
authors: Denise A G
authors: DA
authors: Tonelli
authors: Marcela
authors: M
authors: Pereira
authors: Isadora P
authors: IP
authors: Siba
authors: Bruno J
authors: BJ
authors: Martynhak
authors: Diego
authors: D
authors: Correia
authors: Plínio C
authors: PC
authors: Casarotto
authors: Caroline
authors: C
authors: Biojone
authors: Francisco S
authors: FS
authors: Guimarães
authors: Samia L R
authors: SL
authors: Joca
authors: Roberto
authors: R
authors: Andreatini
mesh_terms: D000818:Animals; D018692:Antimanic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology; D002220:Carbamazepine / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010672:Phenytoin / Q000008:administration & dosage / Q000494:pharmacology*; D014702:Veratrine / Q000494:pharmacology; D061566:Voltage-Gated Sodium Channels / Q000187:drug effects / Q000378:metabolism
chemical_list: D018692:Antimanic Agents; D061566:Voltage-Gated Sodium Channels; D008774:Methylphenidate; D002220:Carbamazepine; D010672:Phenytoin; D014702:Veratrine
keywords: animal model; anticonvulsant; bipolar; mania; methylphenidate; veratrine