title: Effects of seaweed-restructured pork diets enriched or not with cholesterol on rat cholesterolaemia and liver damage.
abstract: Seaweed enriched-restructured pork (RP) is a potential functional food. However, indications of adverse effects associated with herbal medications, which include among others liver failure, toxic hepatitis, and death have been reported. Cholesterol feeding produces hepatomegalia and fat liver infiltration. The effect of seaweed-RP diet, cholesterol-enriched or not, on plasma cholesterol, liver damage markers, structure, and cytochrome CYP4A-1 were evaluated after 5 wk. Eight rat groups were fed a mix of 85% AIN-93M rodent-diet plus 15% RP. The Cholesterol-control (CC), Cholesterol-Wakame (CW), Cholesterol-Nori (CN) and Cholesterol-Sea Spaghetti (CS) groups respectively consumed similar diets to control (C), Wakame (W), Nori (N), and Sea Spaghetti (S) but as part of hypercholesterolaemic diets. CN and CS significantly blocked the hypercholesterolaemic effect observed in CC group. After 5-wk, N and S diets increased the CYP4A-1 expression. However, seaweed-RPs were unable to reduce the histological liver alterations observed in CC group. Larger and more abundant hepatocellular alterations were found in CS and CN rats suggesting that the hypocholesterolaemic effects of these seaweed-RPs seem to be a two-edged sword as they increased liver damage. Future studies are needed to understand the involved mechanisms.
authors: Departamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, E-28040 Madrid, Spain.
authors: Adriana R
authors: AR
authors: Schultz Moreira
authors: Rosa A
authors: RA
authors: García-Fernández
authors: Aranzazu
authors: A
authors: Bocanegra
authors: M Teresa
authors: MT
authors: Méndez
authors: Sara
authors: S
authors: Bastida
authors: Juana
authors: J
authors: Benedí
authors: M Isabel
authors: MI
authors: Sánchez-Reus
authors: Francisco J
authors: FJ
authors: Sánchez-Muniz
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D000072470:Cytochrome P450 Family 4; D004032:Diet; D005234:Fatty Liver / Q000178:diet therapy / Q000503:physiopathology*; D055951:Functional Food; D006937:Hypercholesterolemia / Q000178:diet therapy / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008460:Meat; D009929:Organ Size / Q000187:drug effects; D044664:Porphyra / Q000737:chemistry; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012624:Seaweed / Q000737:chemistry*; D013552:Swine; D044648:Undaria / Q000737:chemistry
chemical_list: D002791:Cholesterol, Dietary; C465387:Cyp4a1protein, rat; D003577:Cytochrome P-450 Enzyme System; D000072470:Cytochrome P450 Family 4; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase