title: Effect of atorvastatin on hematologic parameters in patients with hypercholesterolemia.
abstract: Hematologic parameters such as mean platelet volume (MPV), red cell distribution width (RDW), and neutrophil to lymphocyte (N/L) ratio are associated with increased cardiovascular risk. We investigated the effect of atorvastatin on hematologic parameters in patients with hypercholesterolemia. A total of 79 patients with hypercholesterolemia and 47 normocholesterolemic healthy participants were included. Patients with hypercholesterolemia received 10 to 80 mg/d atorvastatin during a 24-week period. Hematologic parameters were measured at baseline and after 6 months. Atorvastatin treatment produced a significant decrease in MPV levels (9.3 ± 1.3 vs 9.1 ± 1.2 fL, P = .008) and platelet count (259 ± 61 vs 248 ± 51 10(9)/L, P = .005). The N/L ratio decreased significantly after atorvastatin treatment from 2.9 ± 1.2 to 2.6 ± 1.1, (P = .014). The RDW and platelet distribution width levels were not different among the study groups, before and after treatment. Atorvastatin may beneficially reduce MPV levels and N/L ratio. This antiplatelet and anti-inflammatory effect of atorvastatin treatment could play a role in reducing cardiovascular risk.
authors: 1Department of Cardiology, Muğla Sıtkı Kocman University School of Medicine, Muğla, Turkey.
authors: Fatih
authors: F
authors: Akin
authors: Burak
authors: B
authors: Ayça
authors: Nuri
authors: N
authors: Köse
authors: Irfan
authors: I
authors: Sahin
authors: Melike Nur
authors: MN
authors: Akin
authors: Tugba Dübektas
authors: TD
authors: Canbek
authors: Omer
authors: O
authors: Güngör
mesh_terms: D000368:Aged; D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000069059:Atorvastatin; D001772:Blood Cell Count; D004909:Erythrocyte Indices / Q000187:drug effects*; D005260:Female; D006538:Heptanoic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000188:drug therapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000187:drug effects; D011758:Pyrroles / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin
keywords: atorvastatin; mean platelet volume; neutrophil to lymphocyte ratio; red cell distribution width