title: Imaging cortical damage and dysfunction in multiple sclerosis.
abstract: In line with pathological investigations, in vivo magnetic resonance imaging has consistently shown both focal and diffuse damage in the cerebral cortex of patients with multiple sclerosis. Cortical injury tends to progress over time and is only partially related to white matter abnormalities. This review summarizes the main findings from studies using both conventional and modern quantitative magnetic resonance-based techniques for the assessment of cortical damage and dysfunction in patients with multiple sclerosis.
authors: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. filippi.massimo@hsr.it
authors: Massimo
authors: M
authors: Filippi
authors: Maria A
authors: MA
authors: Rocca
authors: Mark A
authors: MA
authors: Horsfield
authors: Simon
authors: S
authors: Hametner
authors: Jeroen J G
authors: JJ
authors: Geurts
authors: Giancarlo
authors: G
authors: Comi
authors: Hans
authors: H
authors: Lassmann
mesh_terms: D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D056784:Leukoencephalopathies / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology