title: Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer.
abstract: BACKGROUND
  Evidence for non-steroidal anti-inflammatory drugs (NSAIDs) preventing head and neck cancer (HNC) is inconclusive; however, there is some suggestion that aspirin may exert a protective effect.
  
  
  METHODS
  Using data from the United States National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined the association between aspirin and ibuprofen use and HNC.
  
  
  RESULTS
  Regular aspirin use was associated with a significant 22% reduction in HNC risk. No association was observed with regular ibuprofen use.
  
  
  CONCLUSIONS
  Aspirin may have potential as a chemopreventive agent for HNC, but further investigation is warranted.
authors: School of Medicine Dentistry and Biomedical Sciences, Institute of Clinical Sciences, Queen's University Belfast, Belfast, UK. wilsonj@uhbs.ch
authors: J C
authors: JC
authors: Wilson
authors: L J
authors: LJ
authors: Murray
authors: C M
authors: CM
authors: Hughes
authors: A
authors: A
authors: Black
authors: L A
authors: LA
authors: Anderson
mesh_terms: D000368:Aged; D000428:Alcohol Drinking; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012306:Risk; D012907:Smoking; D014481:United States / Q000453:epidemiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D007052:Ibuprofen