title: Virulence of Curvularia in a murine model.
abstract: We have evaluated the virulence of two clinically relevant species of Curvularia; Curvularia spicifera and C. hawaiiensis, using an experimental model of disseminated infection in immunocompromised mice. Several inocula were tested over a range 1 × 10(3) -1 × 10(6) colony-forming units/animal. Both species had a similar behaviour, producing a high mortality. Tissue burden and histopathology studies demonstrated that lung was the organ most affected.
authors: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
authors: Katihuska
authors: K
authors: Paredes
authors: Javier
authors: J
authors: Capilla
authors: Deanna A
authors: DA
authors: Sutton
authors: Emilio
authors: E
authors: Mayayo
authors: Annette W
authors: AW
authors: Fothergill
authors: Josep
authors: J
authors: Guarro
mesh_terms: D000825:Animal Structures / Q000382:microbiology / Q000473:pathology; D000818:Animals; D001203:Ascomycota / Q000472:pathogenicity*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D006651:Histocytochemistry; D016867:Immunocompromised Host; D008297:Male; D051379:Mice; D009181:Mycoses / Q000382:microbiology* / Q000473:pathology*; D016019:Survival Analysis; D014774:Virulence
keywords: Animal model; Bipolaris; Curvularia; fungal infections