title: Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats.
abstract: Phytotherapy has a promising future in the management of diabetes, considered to be less toxic and free from side effects as compared to the use of synthetic drugs. The aim of the present study was to assess the antidiabetic possible of orally administered aqueous extracts of Murraya koenigii (ML) and Olea europaea (OL) leaves (100 and 200 mg/kg doses), in streptozotocin (70 mg/kg) induced diabetic rats. Metformin was used as a standard drug. Blood glucose, cholesterol, triglycerides, creatinine levels and body weight were estimated. ML and OL administration showed significant decrease (p>0.05) in cholesterol, triglyceride, and serum glucose levels (range 55.6%-64.6%) compared to the metformin (62.7%); however, there was no significant effect on body weight and serum creatinine. Our results suggest that both the ML and OL possess a potent antihyperglycemic and hypolipidemic effect, which may be due to the presence of antioxidants such as carbazole alkaloids and polyphenols.
authors: Department of Zoology, King Saud University, Riyadh, Saudi Arabia. maielobeid@gmail.com
authors: Maha
authors: M
authors: El-Amin
authors: Promy
authors: P
authors: Virk
authors: Mai Abdel Rahman
authors: MA
authors: Elobeid
authors: Zainab Mohammed
authors: ZM
authors: Almarhoon
authors: Zeinab Korany
authors: ZK
authors: Hassan
authors: Sawsan Ali
authors: SA
authors: Omer
authors: Nada Mohammed
authors: NM
authors: Merghani
authors: Maha Hassan
authors: MH
authors: Daghestani
authors: Ebtisam Mohammed
authors: EM
authors: Al-Olayan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008297:Male; D008687:Metformin / Q000494:pharmacology; D032101:Murraya / Q000737:chemistry*; D031658:Olea / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D013311:Streptozocin; D008687:Metformin; D002784:Cholesterol; D003404:Creatinine