title: Molecular evolution and epidemiology of echovirus 6 in Finland.
abstract: Echovirus 6 (E-6) (family Picornaviridae, genus Enterovirus) is one of the most commonly detected enteroviruses worldwide. The aim of this study was to determine molecular evolutionary and epidemiologic patterns of E-6. A complete genome of one E-6 strain and the partial VP1 coding regions of 169 strains were sequenced and analyzed along with sequences retrieved from the GenBank. The complete genome sequence analysis suggested complex recombination history for the Finnish E-6 strain. In VP1 region, the phylogenetic analysis suggested three major clusters that were further divided to several subclusters. The evolution of VP1 coding region was dominated by negative selection suggesting that the phylogeny of E-6 VP1 gene is predominantly a result of synonymous substitutions (i.e. neutral genetic drift). The partial VP1 sequence analysis suggested wide geographical distribution for some E-6 lineages. In Finland, multiple different E-6 lineages have circulated at the same time.
authors: National Institute for Health and Welfare (THL), P.O. Box 30, FI-00271 Helsinki, Finland. Teemu.Smura@thl.fi
authors: Teemu
authors: T
authors: Smura
authors: Laura
authors: L
authors: Kakkola
authors: Soile
authors: S
authors: Blomqvist
authors: Päivi
authors: P
authors: Klemola
authors: Alun
authors: A
authors: Parsons
authors: Hannimari
authors: H
authors: Kallio-Kokko
authors: Carita
authors: C
authors: Savolainen-Kopra
authors: Denis E
authors: DE
authors: Kainov
authors: Merja
authors: M
authors: Roivainen
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000235:genetics; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D016000:Cluster Analysis; D004458:Echovirus 6, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D004457:Echovirus Infections / Q000453:epidemiology* / Q000821:virology*; D019143:Evolution, Molecular; D005387:Finland / Q000453:epidemiology; D006801:Humans; D017720:Molecular Epidemiology; D010802:Phylogeny; D011995:Recombination, Genetic; D020539:Sequence Analysis, Protein; D012722:Sewage / Q000821:virology
chemical_list: D036022:Capsid Proteins; D012722:Sewage