title: The role of insulin-like growth factor I and hypoxia inducible factor 1α in vascular endothelial growth factor expression in type 2 diabetes.
abstract: BACKGROUND
  Vascular endothelial growth factor (VEGF) plays an important role in diabetic vascular complications, and its expression is affected directly or indirectly by hypoxia inducible factor-1α (HIF-1α) and insulin-like growth factor-I (IGF-I) in tumors and certain normal cell lines. However, little is known about the role of HIF-1α/ IGF-I in VEGF expression in patients with diabetic vascular complications. The aim of this study was to elucidate the associations between HIF-1α, IGF-I, and VEGF in type 2 diabetes mellitus (T2DM) patients with or without vascular complications.
  
  
  METHODS
  Sixty patients with T2DM, with(A), and without vascular disease (B) and 26 controls were enrolled. Clinical parameters, HIF-1α, IGF-I and VEGF were assessed in the study and associations among them were analyzed by Spearman rank correlation.
  
  
  RESULTS
  Serum levels of VEGF, HIF-1α and IGF-I were significantly higher in the diabetic patients than in the controls. Positive correlations existed between VEGF and HIF-1α and between HIF-1α and IL-6 in both groups A and B and in the control group.
  
  
  CONCLUSIONS
  Our data demonstrate that HIF-1α and IL-6 could regulate VEGF expression, and that higher levels of HIF-1α, IL-6, and VEGF may contribute to the pathogenesis of diabetic micro-angiopathy.
authors: Department of Hematology Laboratory, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, P.R.China.
authors: Fang
authors: F
authors: Jiang
authors: Yue-Ting
authors: YT
authors: Tang
authors: Li
authors: L
authors: Guo
authors: Xiao-yang
authors: XY
authors: Jiao
mesh_terms: D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D007334:Insulin-Like Growth Factor I