title: Self-organization of honeycomb-like porous TiO2 films by means of the breath-figure method for surface modification of titanium implants.
abstract: This study describes a facile breath-figure method for the preparation of honeycomb-like porous TiO2 films with an organometallic small-molecule precursor. Multiple characterization techniques have been used to investigate the porous films and a mechanism for the formation process of porous TiO2 films through the breath-figure method is proposed. The pore size of the TiO2 films could be modulated by varying the experimental parameters, such as the concentration of titanium n-butoxide (TBT) solution, the content of cosolvent, and the air flow rate. In vitro cell-culture experiments indicate that NIH 3T3 fibroblast cells seeded on the honeycomb-like porous TiO2 films show good adhesion, spreading, and proliferation behaviors, which suggests that honeycomb-like porous TiO2 films are an attractive biomaterial for surface modification of titanium and its alloys implants in tissue engineering to enhance their biocompatibility and bioactivity.
authors: Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors: Hong
authors: H
authors: Li
authors: Yi
authors: Y
authors: Jia
authors: Mingchun
authors: M
authors: Du
authors: Jinbo
authors: J
authors: Fei
authors: Jie
authors: J
authors: Zhao
authors: Yue
authors: Y
authors: Cui
authors: Junbai
authors: J
authors: Li
mesh_terms: D000497:Alloys; D001672:Biocompatible Materials; D008854:Microscopy, Electron; D016062:Porosity; D019736:Prostheses and Implants; D012996:Solutions; D023822:Tissue Engineering; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D012996:Solutions; C009495:titanium dioxide; D014025:Titanium