title: Assessment of bone metabolism in premenopausal females with hyperthyroidism and hypothyroidism.
abstract: BACKGROUND
  Osteoporosis is one of the commonest metabolic diseases of bone. Its possible causes may include thyroid hormonal dysfunction. The objective of this study was to evaluate the effects of hyperthyroidism and hypothyroidism on osseous tissue metabolism in premenopausal women.
  
  
  METHODS
  38 women with hyperthyroidism, 40 with hypothyroidism and 41 healthy women participated in this study. Initially after 6 and 12 months, each patient underwent selected hormonal, immunological and biochemical tests, measurement of concentrations of bone turnover markers and densitometry were also performed.
  
  
  RESULTS
  On initial evaluation, lower cortical bone density was found in patients with hyperthyroidism (femoral neck). After 12 months, an increase in BMD was seen, but it was still lower than in the control group. Statistically significantly higher concentrations of bone turnover markers, decreasing from the sixth month of treatment, were noted only in the group with hyperthyroidism. Statistically significant differences were not noted in the femoral neck nor in the lumbar spine BMD in patients with hypothyroidism.
  
  
  CONCLUSIONS
  Hyperthyroidism poses a negative effect on bone metabolism. Hypothyroidism in premenopausal females does not have any influence on bone density.
authors: Endocrinology Department, Clinic of Internal Medicine, 4th Military Hospital, Weigla St. 5, Wrocław, Poland. dominess@wp.pl
authors: Dominika
authors: D
authors: Tuchendler
authors: Marek
authors: M
authors: Bolanowski
mesh_terms: D000293:Adolescent; D000328:Adult; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000378:metabolism; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism; D017697:Premenopause / Q000502:physiology*; D011859:Radiography; D012016:Reference Values; D055815:Young Adult
chemical_list: D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide