title: Microfluidic synthesis of cell-type-specific artificial extracellular matrix hydrogels.
abstract: Droplet microfluidic technology is applied for the high-throughput synthesis via Michael-type addition of reactive, micrometer-sized poly(ethylene glycol) (PEG) hydrogels ("microgels") with precisely controlled dimension and physicochemical properties. A versatile chemical scheme is used to modify the reactive PEG microgels with tethered biomolecules to tune their bioactive properties for the bioreactor culture and manipulation of various (stem) cell types.
authors: Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
authors: Simone
authors: S
authors: Allazetta
authors: Tanja C
authors: TC
authors: Hausherr
authors: Matthias P
authors: MP
authors: Lutolf
mesh_terms: D019149:Bioreactors; D060846:Cell Engineering; D002478:Cells, Cultured; D005109:Extracellular Matrix / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D059630:Mesenchymal Stem Cells; D044085:Microfluidics; D011092:Polyethylene Glycols / Q000737:chemistry; D055153:Stem Cell Niche
chemical_list: D020100:Hydrogels; D011092:Polyethylene Glycols