title: A randomized guinea pig study on external cell growth factors after fractional ultrapulsed CO(2) laser therapy.
abstract: OBJECTIVE
  The Fractional Ultrapulsed CO2 laser has been successfully used in treating fine wrinkles, acne scars, and photoaged skin. However, the downtime typically lasts a week or more. The purpose of this study was to observe the efficacy of external cell growth factors after Fractional Ultrapulsed CO2 laser therapy.
  
  
  METHODS
  The back skin of 20 male guinea pigs were divided into four regions after hair removal, then these four regions were irradiated with Fractional Ultrapulsed CO2 laser, respectively. These 80 incised wounds were randomly divided into three therapeutic groups and a control group. The general condition of the wound healing was observed grossly. The determination of physiological functions was done and biopsies were harvested at different time points to compare the change of skin flexibility and fibroblasts number.
  
  
  RESULTS
  The wound healing time of therapeutic groups shortened when compared with the control group. The flexibility of skin and the number of fibroblasts were also more than the control group. The effects of combined application of rhEGF and rb-bFGF therapeutic group were most conspicuous.
  
  
  CONCLUSIONS
  Combined application of rhEGF with rb-bFGF could be more beneficial to the wound after Fractional Ultrapulsed CO2 laser therapy. It could accelerate the wound healing and increase the flexibility of wound skin, so the significance was important to direct clinical application.
authors: Department of Dermatology, Affiliated Hangzhou Clinical College of Anhui Medical University, Hangzhou, PR China.
authors: Jun-Jun
authors: JJ
authors: Ai
authors: Wei-Feng
authors: WF
authors: Zha
authors: Bo
authors: B
authors: Guo
authors: Wei-Min
authors: WM
authors: Song
mesh_terms: D000818:Animals; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D005347:Fibroblasts / Q000378:metabolism; D006168:Guinea Pigs; D054020:Lasers, Gas; D008297:Male; D011897:Random Allocation; D012867:Skin / Q000293:injuries / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects* / Q000528:radiation effects*
chemical_list: D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor