title: Antibacterial activities effectuated by co-continuous epoxy-based polymer materials.
abstract: We report antibacterial activities of the epoxy-resin-based monolithic media (epoxy monoliths) having macroporous co-continuous structure as well as hydrophobic and/or hydrophilic surface. Utilizing epoxy monoliths containing ammonium groups, the antibacterial experiments were examined using Escherichia coli. As the results, the monolithic media prepared with an epoxy monomer having nitrogen atoms clearly showed antibacterial activities, while those prepared using the monomer without nitrogen atom showed less antibacterial activities. Additionally, the quaternization of the epoxy polymers were expressed significant antibacterial activities. Further studies elucidated that the observed antibacterial activities involved the steep effect based on pH changing of solution and hydrophobic interactions by the quaternary ammonium.
authors: Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 6158510, Japan. kubo@anchem.mc.kyoto-u.ac.jp
authors: Takuya
authors: T
authors: Kubo
authors: Koji
authors: K
authors: Yasuda
authors: Yuichi
authors: Y
authors: Tominaga
authors: Koji
authors: K
authors: Otsuka
authors: Ken
authors: K
authors: Hosoya
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004602:Elements; D004853:Epoxy Resins / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions / Q000187:drug effects; D007477:Ions; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D004602:Elements; D004853:Epoxy Resins; D007477:Ions; D011108:Polymers