title: Major themes for 2009 in cardiothoracic and vascular anesthesia.
abstract: The hybrid operating room is the venue for transcatheter therapy with the convergence of three specialties: cardiac surgery, cardiovascular anesthesiology, and interventional cardiology. Transcatheter aortic valve replacement is proof that cardiac specialists have embraced the endovascular revolution. Since pharmacologic and ischemic myocardial conditioning are safe and effective, they are currently the focus of multiple trials. Angiotensin blockade, anemia and endoscopic saphenous vein harvesting worsen outcome after coronary artery bypass grafting (CABG). Although off-pump CABG is equivalent to on-pump CABG, it may improve outcomes in high-risk groups. Although percutaneous coronary intervention (PCI) significantly decreases mortality after myocardial infarction, the evidence is less convincing for intra-aortic balloon counterpulsation. Even though prasugrel was recently approved for platlet blockade in PCI, it may be superceded by ticagrelor. Although PCI and CABG appear equivalent for multivessel coronary disease, CABG lowers revascularization rates and also has superior outcomes in diabetics and the elderly. Hetastarch and N-acetylcysteine both increase bleeding and transfusion in cardiac surgery. Factor VII can treat life-threatening bleeding, but its safety requires further evaluation. Since eltrombopag and romiplostim stimulate platelet production, they may have a future role in hemostasis after cardiac surgery. Even though fenoldopam, atrial natriuretic peptide and sodium bicarbonate are nephroprotective, further trials must confirm these findings. Intensive insulin therapy offers no further outcome advantage and significantly increases hypoglycemic risk. The past year has witnessed the advent of a new clinical venue, new devices, and new drugs. The coming year will most likely advance these achievements.
authors: Department of Anesthesiology and Critical Care, University of Basel; Switzerland.
authors: J
authors: J
authors: Fassl
authors: H
authors: H
authors: Riha
authors: H
authors: H
authors: Ramakrishna
authors: N
authors: N
authors: Singh
authors: T
authors: T
authors: Wyckoff
authors: C
authors: C
authors: Roscher
authors: J G T
authors: JG
authors: Augoustides
keywords: anemia; angiotensin-converting enzyme inhibitors; atrial natriuretic peptide; coronary artery bypass grafting; endovascular saphenous vein graft harvesting; fenoldopam; hetastarch; hybrid operating room; intensive insulin therapy; intra-aortic balloon counterpulsation; ischemic preconditioning; levosimendan; percutaneous coronary intervention; pharmacologic conditioning; prasugrel; sodium bicarbonate; ticagrelor; transcatheter aortic valve replacement; transcatheter mitral valve repair; volatile anesthetics