title: Castleman disease in the pediatric neck: a literature review.
abstract: OBJECTIVE
  To investigate the common features of cervical pediatric Castleman disease.
  
  
  METHODS
  Literature review of pediatric patients with cervical Castleman disease.
  
  
  METHODS
  Online medical journal databases were searched for patients aged 18 years or younger. Eighteen published studies were found, comprising 29 patients.
  
  
  CONCLUSIONS
  An asymptomatic or slowly enlarging neck mass was the most common presentation. No sex differences were noted. Magnetic resonance imaging demonstrates a homogeneous, isointense to slightly hyperintense T1-weighted signal and high signal intensity on T2-weighted imaging. Lymphoma was the most common differential diagnosis. All patients were treated with complete surgical excision and diagnosed as hyaline-vascular type on histology, except for 1 patient for whom histologic type was not reported. No reports of multicentric disease, plasma cell, or mixed histology were found. No recurrences were reported.
  
  
  CONCLUSIONS
  In this article, we provide the largest known literature review of pediatric patients with cervical Castleman disease. Although Castleman disease is rare, it should be considered on the differential for a pediatric neck mass, particularly when presenting with an asymptomatic posterior neck mass and equivocal workup. Fortunately, our study suggests that if diagnosed as Castleman disease, the most likely diagnosis is hyaline-vascular type, for which the long-term prognosis is good. Surgical excision is both diagnostic and therapeutic.
authors: Department of Otolaryngology-Head & Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
authors: Mindy R
authors: MR
authors: Rabinowitz
authors: Jessica
authors: J
authors: Levi
authors: Katrina
authors: K
authors: Conard
authors: Udayan K
authors: UK
authors: Shah
mesh_terms: D000293:Adolescent; D000367:Age Factors; D044963:Biopsy, Fine-Needle; D005871:Castleman Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009333:Neck; D010372:Pediatrics; D011379:Prognosis; D035583:Rare Diseases; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
keywords: hyaline-vascular; neck; unicentric