title: Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration.
abstract: OBJECTIVE
  Antivascular endothelial growth factor (VEGF) agents have been shown to improve visual acuity and prevent vision loss in exudative age-related macular degeneration. As the vision improves relatively quickly in response to intravitreal injections, we wanted to know whether this improvement is reflected in electrophysiological markers of visual cortical processing.
  
  
  METHODS
  Our interventional case series included six elderly patients who underwent injection treatment to the affected eye. Their visual acuity, tomographic images of retinal thickness, and visual evoked potentials (VEP) were assessed before treatment and six weeks after the last injection.
  
  
  RESULTS
  All patients showed improved visual acuity and reduced retinal fluid after the treatment. All but one patient showed increased VEP P100 component amplitudes and/or shortened latencies in the treated eye. These VEP changes were consistent with improved vision while the untreated eyes showed no changes.
  
  
  CONCLUSIONS
  Our results indicate that antivascular endothelial growth factor injections improved visual function of the treated eyes both in the level of the retina and in the level of visual cortical processing.
authors: Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland.
authors: Pasi
authors: P
authors: Vottonen
authors: Kai
authors: K
authors: Kaarniranta
authors: Ari
authors: A
authors: Pääkkönen
authors: Ina M
authors: IM
authors: Tarkka
keywords: age-related eye diseases; exudative age-related macular degeneration; scalp-recorded EEG; visual acuity; visual evoked potentials