title: Stromal plasma cells expressing immunoglobulin G4 subclass in non-small cell lung cancer.
abstract: Inflammatory cell infiltration in tumor stroma may represent the interaction between the tumor and the immune system. The significance of immunoglobulin (Ig) G4+ plasmacytic infiltration, however, is poorly understood. Here, we analyzed the number of stromal IgG4+ plasma cells and the IgG4/IgG ratio of plasma cells in 294 primary non-small cell lung cancers (NSCLCs) using tissue microarray (TMA) and conventional surgical specimens. In TMA, 35 (12%) cases of NSCLC revealed more than 20 IgG4+ plasma cells per high-power field. In surgical specimens, most (97%) of those IgG4+ plasma cell-enriched cases showed obliterative phlebitis or arteritis, one of the key morphologic features of IgG4-related disease, within or at the periphery of the tumor. Clinically, none of the patients showed symptoms associated with IgG4-related systemic diseases. In patients with stage I squamous cell carcinoma, IgG4-enriched stroma was significantly associated with a favorable prognosis (P = .04). In conclusion, considerable IgG4+ plasma cell infiltration can be seen in a minority of cases of NSCLC and might contribute to prognostic modulation of NSCLC.
authors: Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto 606-8507, Japan.
authors: Masakazu
authors: M
authors: Fujimoto
authors: Akihiko
authors: A
authors: Yoshizawa
authors: Shinji
authors: S
authors: Sumiyoshi
authors: Makoto
authors: M
authors: Sonobe
authors: Masashi
authors: M
authors: Kobayashi
authors: Itsuko
authors: I
authors: Koyanagi
authors: Wulamujiang
authors: W
authors: Aini
authors: Tatsuaki
authors: T
authors: Tsuruyama
authors: Hiroshi
authors: H
authors: Date
authors: Hironori
authors: H
authors: Haga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D017154:Stromal Cells / Q000276:immunology* / Q000473:pathology; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D007074:Immunoglobulin G
keywords: IgG4; Lung carcinoma; Plasma cell; Tissue microarray