title: Macro domains as metabolite sensors on chromatin.
abstract: How metabolism and epigenetics are molecularly linked and regulate each other is poorly understood. In this review, we will discuss the role of direct metabolite-binding to chromatin components and modifiers as a possible regulatory mechanism. We will focus on globular macro domains, which are evolutionarily highly conserved protein folds that can recognize NAD(+)-derived metabolites. Macro domains are found in histone variants, histone modifiers, and a chromatin remodeler among other proteins. Here we summarize the macro domain-containing chromatin proteins and the enzymes that generate relevant metabolites. Focusing on the histone variant macroH2A, we further discuss possible implications of metabolite binding for chromatin function.
authors: Institute for Predictive and Personalized Medicine of Cancer (IMPPC), Crta. Can Ruti, Cami de les Escoles, 08916 Badalona, Barcelona, Spain.
authors: Melanija
authors: M
authors: Posavec
authors: Gyula
authors: G
authors: Timinszky
authors: Marcus
authors: M
authors: Buschbeck
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism*; D044127:Epigenesis, Genetic; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D009243:NAD / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D037761:Sirtuins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002843:Chromatin; D006657:Histones; C120756:macroH2A histone; D009243:NAD; D011065:Poly(ADP-ribose) Polymerases; D037761:Sirtuins