title: Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.
abstract: Inactivation of the small guanosine triphosphate-binding protein Ras during receptor signal transduction is mediated by Ras guanosine triphosphatase (GTPase)-activating proteins (RasGAPs). Ten different RasGAPs have been identified and have overlapping patterns of tissue distribution. However, genetic analyses are revealing critical nonredundant functions for each RasGAP in tissue homeostasis and as regulators of disease processes in mouse and man. Here, we discuss advances in understanding the role of RasGAPs in the maintenance of tissue integrity.
authors: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. kingp@umich.edu
authors: Philip D
authors: PD
authors: King
authors: Beth A
authors: BA
authors: Lubeck
authors: Philip E
authors: PE
authors: Lapinski
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D025542:Neurofibromin 1 / Q000502:physiology; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology*; D020729:p120 GTPase Activating Protein / Q000502:physiology; D020703:ras GTPase-Activating Proteins / Q000235:genetics* / Q000502:physiology*; D018631:ras Proteins / Q000502:physiology*
chemical_list: D025542:Neurofibromin 1; C581321:RASA1 protein, mouse; C102193:RASA2 protein, human; C484739:SYNGAP1 protein, human; D020729:p120 GTPase Activating Protein; D020703:ras GTPase-Activating Proteins; D018631:ras Proteins