title: Subcutaneous phaeohyphomycosis caused by Exophiala equina, with susceptibility to eight antifungal drugs.
abstract: A case of subcutaneous phaeohyphomycosis caused by Exophiala equina is reported in a 75-year-old female, who showed subcutaneous abscesses on both forearms for 8 months. A lesion was initiated by inoculation with a spine from a tree. Histopathologically, suppurative granulomatous inflammation was present and short hyphal elements were observed. Upon culture greyish-black, velvety colonies of a black yeast were obtained after 3 weeks. The strain grew well at 25 °C, but poorly at 37 °C. After sequencing the internal transcribed spacer domain and the partial β-tubulin gene, the fungus was identified as E. equina. The patient was successfully treated with fluconazole for 3 months.
authors: Department of Parasitology and Mycology, and Cancer Molecular Pathology Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Mohammad Javad
authors: MJ
authors: Najafzadeh
authors: Departments of Dermatology, Dongguk University, Gyeongju, South Korea.
authors: Moo Kyu
authors: MK
authors: Suh
authors: Departments of Dermatology, Dongguk University, Gyeongju, South Korea.
authors: Myung Hoon
authors: MH
authors: Lee
authors: Laboratory Medicine, Dongguk University, Gyeongju, South Korea.
authors: Gyoung Yim
authors: GY
authors: Ha
authors: Pathology, College of Medicine, Dongguk University, Gyeongju, South Korea.
authors: Jung Ran
authors: JR
authors: Kim
authors: White Skin Clinic, Changwon, South Korea.
authors: Tae Heung
authors: TH
authors: Kim
authors: Department of Dermatology, College of Medicine, Yeungnam University, Daegu, South Korea.
authors: Hyo Jin
authors: HJ
authors: Lee
authors: Department of Dermatology, College of Medicine, Yeungnam University, Daegu, South Korea.
authors: Jong Soo
authors: JS
authors: Choi
authors: Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
authors: Jacques F
authors: JF
authors: Meis
authors: Peking University Health Science Center, Research Center for Medical Mycology, Beijing, PR China.|Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, The Netherlands.|CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
authors: G Sybren
authors: GS
authors: De Hoog
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004271:DNA, Fungal / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D026141:Drug Resistance, Multiple, Fungal; D005093:Exophiala / Q000187:drug effects* / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D025301:Hyphae; D008826:Microbial Sensitivity Tests; D060446:Phaeohyphomycosis / Q000188:drug therapy / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer