title: 1,3,4-thiadiazole and its derivatives: a review on recent progress in biological activities.
abstract: The 1,3,4-thiadiazole nucleus is one of the most important and well-known heterocyclic nuclei, which is a common and integral feature of a variety of natural products and medicinal agents. Thiadiazole nucleus is present as a core structural component in an array of drug categories such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antineoplastic, and antitubercular agents. The broad and potent activity of thiadiazole and their derivatives has established them as pharmacologically significant scaffolds. In this study, an attempt has been made with recent research findings on this nucleus, to review the structural modifications on different thiadiazole derivatives for various pharmacological activities.
authors: Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradhesh, India. abhishekjain2105@rediffmail.com
authors: Abhishek Kumar
authors: AK
authors: Jain
authors: Simant
authors: S
authors: Sharma
authors: Ankur
authors: A
authors: Vaidya
authors: Veerasamy
authors: V
authors: Ravichandran
authors: Ram Kishore
authors: RK
authors: Agrawal
mesh_terms: D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000737:chemistry*
chemical_list: D013830:Thiadiazoles; C058949:1,3,4-thiadiazole