title: Genetic genealogy comes of age: perspectives on the use of deep-rooted pedigrees in human population genetics.
abstract: In this article, we promote the implementation of extensive genealogical data in population genetic studies. Genealogical records can provide valuable information on the origin of DNA donors in a population genetic study, going beyond the commonly collected data such as residence, birthplace, language, and self-reported ethnicity. Recent studies demonstrated that extended genealogical data added to surname analysis can be crucial to detect signals of (past) population stratification and to interpret the population structure in a more objective manner. Moreover, when in-depth pedigree data are combined with haploid markers, it is even possible to disentangle signals of temporal differentiation within a population genetic structure during the last centuries. Obtaining genealogical data for all DNA donors in a population genetic study is a labor-intensive task but the vastly growing (genetic) genealogical databases, due to the broad interest of the public, are making this job more time-efficient if there is a guarantee for sufficient data quality. At the end, we discuss the advantages and pitfalls of using genealogy within sampling campaigns and we provide guidelines for future population genetic studies.
authors: UZ Leuven, Laboratory of Forensic Genetics and Molecular Archaeology, Leuven, Belgium. maarten.larmuseau@bio.kuleuven.be
authors: M H D
authors: MH
authors: Larmuseau
authors: A
authors: A
authors: Van Geystelen
authors: M
authors: M
authors: van Oven
authors: R
authors: R
authors: Decorte
mesh_terms: D000885:Anthropology, Physical; D004247:DNA / Q000235:genetics; D005789:Genealogy and Heraldry; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation; D005828:Genetics, Population / Q000379:methods*; D006801:Humans; D009275:Names; D010375:Pedigree
chemical_list: D005819:Genetic Markers; D004247:DNA