title: IgG4: a tantalizing link between causes of membranous glomerulonephritis and systemic disease.
abstract: Alexander et al. give a detailed description of IgG4-related membranous glomerulonephritis (MGN). Their data delineate for the first time in IgG4-related disease (IgG4-RD) a second pattern of tissue injury occurring within the same organ. The paper highlights that MGN can occur alone or simultaneously with IgG4-related tubulointerstitial nephritis. Thus, it extends our understanding of IgG4-RD and illuminates potential pathways for new investigations into its pathophysiology.
authors: Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. jhstone@partners.org
authors: John H
authors: JH
authors: Stone
mesh_terms: D005260:Female; D015433:Glomerulonephritis, Membranous / Q000209:etiology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D009395:Nephritis, Interstitial / Q000150:complications*
chemical_list: D007074:Immunoglobulin G