title: [Mathematic concept model of accumulation of functional disorders associated with environmental factors].
abstract: The mathematic concept model presented describes accumulation of functional disorders associated with environmental factors, plays predictive role and is designed for assessments of possible effects caused by heterogenous factors with variable exposures. Considering exposure changes with self-restoration process opens prospects of using the model to evaluate, analyse and manage occupational risks. To develop current theoretic approaches, the authors suggested a model considering age-related body peculiarities, systemic interactions of organs, including neuro-humoral regulation, accumulation of functional disorders due to external factors, rehabilitation of functions during treatment. General objective setting covers defining over a hundred unknow coefficients that characterize speed of various processes within the body. To solve this problem, the authors used iteration approach, successive identification, that starts from the certain primary approximation of the model parameters and processes subsequent updating on the basis of new theoretic and empirical knowledge.
authors: N V
authors: NV
authors: Zaĭtseva
authors: P V
authors: PV
authors: Trusov
authors: D A
authors: DA
authors: Kir'ianov
mesh_terms: D000222:Adaptation, Physiological; D000367:Age Factors; D004777:Environment; D018876:Environmental Illness; D006801:Humans; D008962:Models, Theoretical; D055361:Multilevel Analysis; D009784:Occupational Diseases / Q000145:classification / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D016273:Occupational Exposure / Q000009:adverse effects / Q000145:classification / Q000517:prevention & control; D011336:Probability; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013997:Time Factors