title: Clostridium difficile-associated diarrhea in an ocelot (Leopardus pardalis).
abstract: The aim of this study is to report a case of Clostridium difficile-associated diarrhea in an ocelot (Leopardus pardalis) in the state of Mato Grosso do Sul, Brazil. The animal, a 24-month-old male, was referred to the Centro de Reabilitação de Animais Silvestres (CRAS) with a history of having been run over and tibia and fibula fractures. After a surgery to repair the fractures, the ocelot underwent antibiotic therapy with two doses of sodium cefovecin, during which he presented with diarrhea. A stool sample was positive for A/B toxins by a cytotoxicity assay, and a toxigenic strain of C. difficile was isolated. No other enteropathogens were detected. The association between the history, clinical signs and laboratory exams confirmed the diagnosis of C. difficile-associated diarrhea. The present report confirms C. difficile as a potential pathogen for wild felids and suggests that the C. difficile-associated diarrhea should be considered in diarrhea cases, especially when the clinical signs began after antimicrobial use.
authors: Veterinary School, Universidade Federal de Minas Gerais (UFMG), Antônio Carlos Avenue 6627, Belo Horizonte 31.270-901, MG, Brazil. rodrigo.otaviosilva@gmail.com
authors: Rodrigo Otávio Silveira
authors: RO
authors: Silva
authors: Mirella Lauria
authors: ML
authors: D'elia
authors: Danielle Ferreira
authors: DF
authors: de Magalhães Soares
authors: Álvaro Roberto
authors: ÁR
authors: Cavalcanti
authors: Rodrigo Costa
authors: RC
authors: Leal
authors: Guilherme
authors: G
authors: Cavalcanti
authors: Pedro Lúcio Lithg
authors: PL
authors: Pereira
authors: Francisco Carlos Faria
authors: FC
authors: Lobato
mesh_terms: D000818:Animals; D000835:Animals, Wild / Q000382:microbiology; D001938:Brazil; D016360:Clostridioides difficile / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D003967:Diarrhea / Q000175:diagnosis / Q000382:microbiology / Q000662:veterinary*; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000382:microbiology / Q000662:veterinary*; D005243:Feces / Q000382:microbiology; D045989:Felidae / Q000382:microbiology*; D008297:Male