title: An ATP2B4 polymorphism protects against malaria in pregnancy.
abstract: Polymorphisms of ATP2B4 encoding an ubiquitous Ca(2+) pump protect against severe childhood malaria. We assessed the influence of a main polymorphism (rs10900585) on malaria among 834 delivering Ghanaian women. In homozygous primiparae, the odds of placental Plasmodium falciparum infection were reduced by 64%. No influence of the polymorphism on parasite density, low birth weight, or preterm delivery was discernible. However, malarial anemia was greatly reduced in primiparous carriers of the variant allele, paralleling the reduced impact of malaria on hemoglobin levels in this group. A common ATP2B4 polymorphism protects against malaria in pregnancy and related maternal anemia, suggesting ATP2B4 variant associated protection not to be limited to severe childhood malaria.
authors: Department of Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors: George
authors: G
authors: Bedu-Addo
authors: Stefanie
authors: S
authors: Meese
authors: Frank P
authors: FP
authors: Mockenhaupt
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D000740:Anemia / Q000235:genetics* / Q000469:parasitology; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000235:genetics* / Q000469:parasitology; D010920:Placenta / Q000469:parasitology / Q000473:pathology; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000235:genetics*; D055815:Young Adult
chemical_list: D006454:Hemoglobins; C507517:ATP2B4 protein, human; D053499:Plasma Membrane Calcium-Transporting ATPases