title: Regulated unfolding of proteins in signaling.
abstract: The transduction of biological signals often involves structural rearrangements of proteins in response to input signals, which leads to functional outputs. This review discusses the role of regulated partial and complete protein unfolding as a mechanism of controlling protein function and the prevalence of this regulatory mechanism in signal transduction pathways. The principles of regulated unfolding, the stimuli that trigger unfolding, and the coupling of unfolding with other well characterized regulatory mechanism are discussed.
authors: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
authors: Diana M
authors: DM
authors: Mitrea
authors: Richard W
authors: RW
authors: Kriwacki
mesh_terms: D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D058767:Protein Unfolding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011506:Proteins