title: Metabolic management in overweight subjects with naive impaired fasting glycaemia by means of a highly standardized extract from Cynara scolymus: a double-blind, placebo-controlled, randomized clinical trial.
abstract: The aim of this study is to evaluate the efficacy of a dietary supplementation with an extract from Cynara scolymus (Cs) on the glucose pattern in a group of patients with naïve impaired fasting glycaemia (IFG). A randomized, double-blind, placebo-controlled trial has been performed in 55 overweight subjects with IFG (fasting blood glucose [FBG]: 6.11 ± 0.56 mmol/l). These subjects were randomly assigned to supplement their diet with either an extract from Cs (600 mg/d) (26 subjects) or placebo (29 matched subjects) for 8 weeks. The decrease of FBG was the primary endpoint. The assessment of Homeostatic Metabolic Assessment (HOMA), glycosylated haemoglobin, A1c-Derived Average Glucose (ADAG), lipidic pattern and anthropometric parameters were the secondary endpoints. The within groups and percent changes from baseline were analyzed by the signed rank test. The comparison between groups was performed by Wilcoxon's two sample test. The supplemented group had significant decreases of: FBG (-9.6%), HOMA (-11.7%), glycosylated haemoglobin (-2.3%), ADAG (-3.1%) and lipidic pattern. The placebo group did not show any significant difference. Compared with the placebo, the supplemented group showed a significant difference in FBG, HOMA and lipidic pattern. These data demonstrate the efficacy of Cs extract on the reduction of glycometabolic parameters in overweight subjects with IFG.
authors: University of Pavia, Health Sciences Department, Section of Human Nutrition, Azienda di Servizi alla Persona, Via Emilia n.12, Pavia, Italy.
authors: Mariangela
authors: M
authors: Rondanelli
authors: Annalisa
authors: A
authors: Opizzi
authors: Milena
authors: M
authors: Faliva
authors: Patrizio
authors: P
authors: Sala
authors: Simone
authors: S
authors: Perna
authors: Antonella
authors: A
authors: Riva
authors: Paolo
authors: P
authors: Morazzoni
authors: Ezio
authors: E
authors: Bombardelli
authors: Attilio
authors: A
authors: Giacosa
mesh_terms: D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis*; D002784:Cholesterol / Q000097:blood; D031943:Cynara scolymus / Q000737:chemistry*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin; D010936:Plant Extracts; D014280:Triglycerides
keywords: Cynara scolymus; dietary supplement; impaired fasting glycaemia; overweight