title: Interactions between new quinolone antibacterials and diagnostic drug containing manganese.
abstract: A diagnostic drug containing manganese chloride tetrahydrate as a major ingredient is available since 2006. It is used in magnetic resonance imaging as a negative contrast medium for magnetic resonance cholangiopancreatography of the gastrointestinal tract. However, there is no report regarding interaction between manganese and new quinolone antibacterials. We investigated the interactions between new quinolone antibacterials and a diagnostic drug containing manganese in vitro. We evaluated the rate of formation of chelate complex by reacting new quinolone antibacterials (levofloxacin, ofloxacin, ciprofloxacin) with a diagnostic drug containing manganese. The EC50 values of the formation of chelate complex for levofloxacin, ofloxacin, and ciprofloxacin were 5.14 ± 0.14, 5.29 ± 0.14, and 0.96 ± 0.04 mM, respectively. The rates of formation of chelate complex by levofloxacin, ofloxacin, and ciprofloxacin in a reaction with the diagnostic drug were 17.0, 18.9, and 55.5 % in clinical condition, respectively. Our results suggest that a complex of each antibacterial and manganese was formed, with ciprofloxacin causing the strongest interaction. In addition, our findings indicate that the degree of interaction may be an important problem in clinical settings with concomitant administration of a new quinolone antibacterial and diagnostic drug containing manganese.
authors: Department of Clinical Evaluation of Drug Efficacy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
authors: Moeko
authors: M
authors: Hosono
authors: Haruko
authors: H
authors: Yokoyama
authors: Risa
authors: R
authors: Takayanagi
authors: Yasuhiko
authors: Y
authors: Yamada
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002939:Ciprofloxacin / Q000737:chemistry; D004347:Drug Interactions; D064704:Levofloxacin / Q000737:chemistry; D017895:Manganese Compounds / Q000737:chemistry*; D015242:Ofloxacin / Q000737:chemistry; D015363:Quinolones / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D002614:Chelating Agents; D017895:Manganese Compounds; D015363:Quinolones; D002939:Ciprofloxacin; D064704:Levofloxacin; D015242:Ofloxacin