title: An updated meta-analysis of the Fc receptor-like 3 -169T/C polymorphism and rheumatoid arthritis risk.
abstract: OBJECTIVE
  Published studies have shown conflicting results concerning the association between the -169T/C promoter polymorphism in the Fc receptor-like 3 (FCRL3) gene and rheumatoid arthritis (RA). In this study we conducted an up-to-date meta-analysis to examine the relationship.
  
  
  METHODS
  We searched the PubMed database for all papers published up to 20 April 2012. Overall, 18 case-control studies with 12 620 cases and 12 613 controls were retrieved based on the search criteria for RA susceptibility related to the FCRL3 -169T/C polymorphism. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of this association. Publication bias was assessed using the Egger test.
  
  
  RESULTS
  We found that the FCRL3 -169T/C polymorphism increased the risk for RA overall in genetic models (allelic contrast: OR 1.09, 95% CI 1.03-1.14, p = 0.001; homozygote comparison: OR 1.20, 95% CI 1.08-1.34, p = 0.001; dominant genetic model: OR 1.03, 95% CI 1.01-1.05, p = 0.001). Stratified analysis by race also showed a significant positive association with Asians and Caucasians. Subgroup analysis of rheumatoid factor (RF) revealed a slightly positive relationship between the FCRL3 -169T/C polymorphism and RF-positive RA risk. No obvious evidence of publication bias was detected in the overall analysis.
  
  
  CONCLUSIONS
  Our study indicates that the FCRL3 -169T/C polymorphism is significantly associated with increased RA risk.
authors: Department of Orthopaedics, The Affiliated Changzhou No. 2 Hospital of Nanjing Medical University, Changzhou, China.
authors: L M
authors: LM
authors: Nong
authors: K W
authors: KW
authors: Ren
authors: Y Y
authors: YY
authors: Mi
authors: N W
authors: NW
authors: Xu
authors: D
authors: D
authors: Zhou
mesh_terms: D001172:Arthritis, Rheumatoid / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011971:Receptors, Immunologic / Q000235:genetics*; D018570:Risk Assessment; D012680:Sensitivity and Specificity
chemical_list: C457775:FCRL3 protein, human; D011971:Receptors, Immunologic