title: Facile synthesis of novel D-ring modified steroidal dienamides via rearrangement of 2H-pyrans.
abstract: A simple and practical method for synthesis of the D-ring modified steroidal dienamides (4a-k) from the steroidal α,α-dicyanoalkene 3 and aldehydes via vinylogous aldol reaction was first reported. By using NaOAc as a base, the desired products were obtained in moderate to good yields in ethanol under mild conditions. All the synthesized steroidal dienamides are new and are currently being evaluated for their biological activities.
authors: School of Pharmaceutical Sciences and New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, PR China.
authors: Bin
authors: B
authors: Yu
authors: En
authors: E
authors: Zhang
authors: Xiao-Nan
authors: XN
authors: Sun
authors: Jing-Li
authors: JL
authors: Ren
authors: Yuan
authors: Y
authors: Fang
authors: Bao-Le
authors: BL
authors: Zhang
authors: De-Quan
authors: DQ
authors: Yu
authors: Hong-Min
authors: HM
authors: Liu
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D011714:Pyrans / Q000737:chemistry*; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000475:Alkenes; D011714:Pyrans; D013256:Steroids