title: Periprosthetic aseptic osteolysis in total ankle replacement: cause and management.
abstract: Osteolysis is the loss of bone secondary to a pathologic process and remains the most common cause of failure of total ankle replacement. Friction at the bearing surface results in the generation of abraded wear debris of polyethylene. These activate a biologic cascade that may result in significant bone loss and subsequent loss of fixation of the prosthesis. Revision surgery must address this loss of bone and may be achieved through either bone grafting or use of appropriate revision prosthesis components.
authors: Division of Orthopaedic & Accident Surgery, Nottingham University Hospital NHS Trust, Derby Road, Nottingham NG7 2UH, UK.
authors: Mark T R
authors: MT
authors: Gaden
authors: Benjamin J
authors: BJ
authors: Ollivere
mesh_terms: D000843:Ankle Joint / Q000601:surgery*; D019643:Arthroplasty, Replacement / Q000009:adverse effects*; D016025:Bone Transplantation; D019544:Equipment Failure Analysis; D006801:Humans; D008264:Macrophages / Q000502:physiology; D010006:Osteoblasts / Q000473:pathology / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010014:Osteolysis / Q000145:classification / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D011475:Prosthesis Failure / Q000209:etiology; D019651:Plastic Surgery Procedures; D012086:Reoperation