title: Diffusion-weighted imaging for evaluation of uterine arterial embolization of fibroids.
abstract: OBJECTIVE
  To determine whether diffusion-weighted imaging (DWI) characteristics could predict the effectiveness of uterine arterial embolization in treatment of fibroids.
  
  
  METHODS
  This retrospective study included 17 women (27 fibroids) who underwent uterine arterial embolization for fibroids. MR imaging (1.5 T) was performed before, 1 week and 6 months after uterine arterial embolization. The volume, T2 signal, T1 signal, enhancement after contrast media injection, DWI signal (b = 500 s/mm(2) ) and apparent diffusion coefficient (ADC) were assessed for fibroids.
  
  
  RESULTS
  DWI signal or ADC, whether before or 1 week after the procedure, did not show a statistical relationship to success of uterine arterial embolization. On the 1-week follow-up, 22% of fibroids enhanced vs. 85% on baseline, P < 0.0001 and DW signal intensity increased. ADC values in fibroids decreased between baseline and 1-week (1.61 vs. 1.53 × 10(-3) mm(2) /s, P = 0.13). On 6-months, ADC continued to decrease compared with baseline (1.27 × 10(-3) mm(2) /s, P = 0.002), but with a lower signal on DWI. No changes were observed in myometrium ADC at any time point.
  
  
  CONCLUSIONS
  Our study demonstrated that DWI and ADC reflected early and delayed changes in fibroids after embolization; however, we were not able to demonstrate a statistically significant relationship with outcome.
authors: Université Paris Descartes Sorbonne Paris Cité, INSERM UMR-S970, Cardiovascular Research Center-PARCC, Paris, France.
authors: Nathalie
authors: N
authors: Faye
authors: Olivier
authors: O
authors: Pellerin
authors: Rokhaya
authors: R
authors: Thiam
authors: Foucauld
authors: F
authors: Chammings
authors: Marie
authors: M
authors: Brisa
authors: Enio
authors: E
authors: Marques
authors: Charles A
authors: CA
authors: Cuénod
authors: Marc
authors: M
authors: Sapoval
authors: Laure S
authors: LS
authors: Fournier
mesh_terms: D000180:Acrylic Resins / Q000627:therapeutic use*; D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005780:Gelatin / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D007889:Leiomyoma / Q000473:pathology* / Q000628:therapy*; D008875:Middle Aged; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D055357:Uterine Artery Embolization / Q000379:methods*; D014594:Uterine Neoplasms / Q000473:pathology* / Q000628:therapy*
chemical_list: D000180:Acrylic Resins; D006490:Hemostatics; C496735:trisacryl gelatin microspheres; D005780:Gelatin
keywords: MRI; apparent diffusion coefficient; diffusion-weighted imaging; fibroid; uterine arterial embolization