title: The therapeutic efficacy of propranolol in children with recurrent primary epistaxis.
abstract: We hypothesized that some characteristics of beta-blockers, including negative inotropic, peripheral vasoconstrictor, and antiangiogenic effects, might be potentially useful in treating children with epistaxis. From June 2010 to March 2012, a total of seven children with recurrent primary epistaxis resistant to conventional management were observed at our institution. An overall effectiveness of propranolol was noted in all seven children when given a dose of 1.5-2 mg/kg/day (divided into three doses) as a second line therapy for terminating epistaxis. Based on our first experience, we believe that propranolol could be a favorable treatment option for patients with primary epistaxis.
authors: Clinic of Pediatrics, Clinical Center, Nis, Serbia. bojko968@gmail.com
authors: Bojko
authors: B
authors: Bjelakovic
authors: Mila
authors: M
authors: Bojanovic
authors: Stevo
authors: S
authors: Lukic
authors: Ljiljana
authors: L
authors: Saranac
authors: Vladislav
authors: V
authors: Vukomanovic
authors: Sergej
authors: S
authors: Prijic
authors: Nikola
authors: N
authors: Zivkovic
authors: Dusica
authors: D
authors: Randjelovic
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004844:Epistaxis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol
keywords: beta-blocker; children; epistaxis