title: Sugary food and beverage consumption and epithelial ovarian cancer risk: a population-based case-control study.
abstract: BACKGROUND
  Ovarian cancer is the deadliest gynecologic cancer in the US. The consumption of refined sugars has increased dramatically over the past few decades, accounting for almost 15% of total energy intake. Yet, there is limited evidence on how sugar consumption affects ovarian cancer risk.
  
  
  METHODS
  We evaluated ovarian cancer risk in relation to sugary foods and beverages, and total and added sugar intakes in a population-based case-control study. Cases were women with newly diagnosed epithelial ovarian cancer, older than 21 years, able to speak English or Spanish, and residents of six counties in New Jersey. Controls met same criteria as cases, but were ineligible if they had both ovaries removed. A total of 205 cases and 390 controls completed a phone interview, food frequency questionnaire, and self-recorded waist and hip measurements. Based on dietary data, we computed the number of servings of dessert foods, non-dessert foods, sugary drinks and total sugary foods and drinks for each participant. Total and added sugar intakes (grams/day) were also calculated. Multiple logistic regression models were used to estimate odds ratios and 95% confidence intervals for food and drink groups and total and added sugar intakes, while adjusting for major risk factors.
  
  
  RESULTS
  We did not find evidence of an association between consumption of sugary foods and beverages and risk, although there was a suggestion of increased risk associated with sugary drink intake (servings per 1,000 kcal; OR=1.63, 95% CI: 0.94-2.83).
  
  
  CONCLUSIONS
  Overall, we found little indication that sugar intake played a major role on ovarian cancer development.
authors: The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany St. New Brunswick, NJ 08903, USA.
authors: Melony G
authors: MG
authors: King
authors: Sara H
authors: SH
authors: Olson
authors: Lisa
authors: L
authors: Paddock
authors: Urmila
authors: U
authors: Chandran
authors: Kitaw
authors: K
authors: Demissie
authors: Shou-En
authors: SE
authors: Lu
authors: Niyati
authors: N
authors: Parekh
authors: Lorna
authors: L
authors: Rodriguez-Rodriguez
authors: Elisa V
authors: EV
authors: Bandera
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001628:Beverages / Q000009:adverse effects; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D015930:Diet Records; D019422:Dietary Sucrose / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology / Q000209:etiology*; D009515:New Jersey / Q000453:epidemiology; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D019422:Dietary Sucrose