title: Cell cultured chondrocyte implantation and scaffold techniques for osteochondral talar lesions.
abstract: Cell cultured techniques have gained interest and popularity in osteochondral defects because, unlike bone marrow stimulation methods, where fibrocartilage fills the defect, they allow for the regeneration of "hyaline-like cartilage" with better stiffness, resilience, and wear characteristics. Osteochondral defects in the ankle are a rare but challenging problem to treat in young active patients. If left alone, they can cause pain and reduced function and risk progressive degenerative changes in the joint. Clinical results of cell cultured and scaffold technology in the ankle, although still limited by small studies and midterm follow-up, are certainly encouraging.
authors: Trauma and Orthopaedic Department, Robert Jones and Agnes Hunt Orthopaedic and District Hospital NHS Trust, Oswestry, Shropshire SY10 7AG, UK.
authors: Ben
authors: B
authors: Johnson
authors: Caroline
authors: C
authors: Lever
authors: Sally
authors: S
authors: Roberts
authors: James
authors: J
authors: Richardson
authors: Helen
authors: H
authors: McCarthy
authors: Paul
authors: P
authors: Harrison
authors: Patrick
authors: P
authors: Laing
authors: Nilesh
authors: N
authors: Makwana
mesh_terms: D000843:Ankle Joint / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D002358:Cartilage, Articular / Q000473:pathology* / Q000601:surgery; D018929:Cell Culture Techniques; D019902:Chondrocytes / Q000637:transplantation*; D006801:Humans; D019637:Orthopedic Procedures / Q000379:methods*; D010007:Osteochondritis / Q000601:surgery*; D013628:Talus / Q000601:surgery* / Q000637:transplantation; D014182:Transplantation, Autologous / Q000379:methods*