title: [Assessment of a Tiapride solution for its administration through continuous intravenous perfusion].
abstract: OBJECTIVE
  Tiapride is a substituted benzamide classified as an atypical neuroleptic. To our knowledge, there are no published data on its stability prepared as a continuous intravenous infusion. The current study analysed its stability in two different infusion solutions and concentrations over 48 hours.
  
  
  METHODS
  Triplicate samples of tiapride were prepared in 0.9% sodium chloride and in 5% dextrose solutions at final concentrations of 1 and 2 mg/ml. Samples were collected in glass bottles without photoprotection and at room temperature (25 ± 2 °C). Sampling times at 0, 1, 3, 6, 12, 24 and 48 hours included a visual inspection for colour changes and appearance of precipitation as well as pH determination. Tiapride was quantified at selected times by mass spectrometry using high-performance liquid chromatography. Concentration values in the samples corresponding to 0 hours were given a reference value of 100%. Concentrations in subsequent samples greater than 90% were considered stable.
  
  
  RESULTS
  No colour change or precipitation was observed during the study period. pH values ranged between 0.1 and 0.4 units. At 48 hours, the concentration of remaining tiapride in sodium chloride 1 mg/ml and 2 mg/ml was 93.8% and 91.6%, respectively. That in 5% dextrose 1 mg/ml and 2 mg/ml was 96.8% and 94.1%, respectively.
  
  
  CONCLUSIONS
  Dilutions of tiapride in 0.9% sodium chloride and in 5% dextrose solution, at concentrations of 1 mg/ml and 2 mg/ml, in glass bottles and at room temperature were stable both physically and chemically during 48 hours.
authors: F
authors: F
authors: Mendoza-Otero
authors: J A
authors: JA
authors: Gómez Vidal
authors: N
authors: N
authors: Vila-Clérigues
authors: M
authors: M
authors: Muros-Ortega
authors: O
authors: O
authors: García-Molina
authors: A
authors: A
authors: De La Rubia Nieto
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000737:chemistry*; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D004349:Drug Packaging; D004355:Drug Stability; D005947:Glucose; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D013058:Mass Spectrometry; D012965:Sodium Chloride; D012996:Solutions; D013696:Temperature; D063325:Tiapride Hydrochloride / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D014150:Antipsychotic Agents; D012996:Solutions; D012965:Sodium Chloride; D063325:Tiapride Hydrochloride; D005947:Glucose