title: Ultra-small NLC for improved dermal delivery of coenyzme Q10.
abstract: Coenzyme Q10 (CoQ10) acts as an antioxidant in the skin and is frequently contained in anti-aging products. In previous studies, it could be shown that nano-structured lipid carriers (NLC) with a size of about 230 nm are beneficial for the dermal delivery of CoQ10. They increased Q10 skin penetration when compared to equally sized nanoemulsion. In this study, ultra-small NLC were prepared with even smaller mean particles sizes of around 80 nm. The influence of this decrease of particle size was investigated in terms of skin permeation and penetration as well as physicochemical stability of the NLC. Improved dermal delivery of CoQ10 by ultra-small NLC could be achieved.
authors: University of Vienna, Research Platform Characterisation of Drug Delivery Systems on Skin and Investigation of Involved Mechanisms, Althanstraße 14, 1090 Vienna, Austria. julia.schwarz@univie.ac.at
authors: Julia C
authors: JC
authors: Schwarz
authors: Nuttakorn
authors: N
authors: Baisaeng
authors: Magdalena
authors: M
authors: Hoppel
authors: Monika
authors: M
authors: Löw
authors: Cornelia M
authors: CM
authors: Keck
authors: Claudia
authors: C
authors: Valenta
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D008055:Lipids / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013552:Swine; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000975:Antioxidants; D004337:Drug Carriers; D008055:Lipids; D014451:Ubiquinone; C024989:coenzyme Q10