title: Ulososides and urabosides--triterpenoid saponins from the Caribbean marine sponge Ectyoplasia ferox.
abstract: Three new triterpene glycosides, named ulososide F (1), urabosides A (2) and B (3), together with the previously reported ulososide A (4), were isolated from the Caribbean marine sponge Ectyoplasia ferox. Their structures were elucidated using extensive interpretation of 1D and 2D-NMR data, as well as HRESIMS. The aglycon of all compounds is a rare 30-norlonastane and the sugar residues were identified after acid hydrolysis and GC analyses. Cytotoxicities of the isolated compounds were evaluated against Jurkat and CHO cell lines by a MTT in vitro assay as well as a hemolysis assay. Unexpectedly, all these saponin derivatives showed very low activity in our bioassays.
authors: Grupo de Investigación Productos Naturales Marinos, Facultad de Química Farmacéutica, Universidad de Antioquia, A.A 1226, Medellín, Colombia. jhonnycolorado@humax.com.co
authors: Jhonny
authors: J
authors: Colorado
authors: Diana
authors: D
authors: Muñoz
authors: Diana
authors: D
authors: Marquez
authors: Maria Elena
authors: ME
authors: Marquez
authors: Juan
authors: J
authors: Lopez
authors: Olivier P
authors: OP
authors: Thomas
authors: Alejandro
authors: A
authors: Martinez
mesh_terms: D000818:Animals; D016466:CHO Cells; D002460:Cell Line; D006224:Cricetinae; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D012503:Saponins; D014315:Triterpenes