title: Periaortitis associated with anti-neutrophil cytoplasmic antibodies induced by bevacizumab combination therapy.
abstract: Drug-induced vessel vasculitis is a rare complication of chemotherapy. In particular, few reports have investigated drug-induced large vessel vasculitis. We herein report the case of a 57-year-old woman with advanced lung adenocarcinoma who developed perinuclear anti-neutrophil cytoplastic antibodies (p-ANCA)-positive periaortitis induced by bevacizumab combination chemotherapy. With the increasing use of combination therapy with bevacizumab, the incidence of vascular complications will potentially increase. A noninfectious fever occurring during chemotherapy might be a sign of vasculitis; therefore, we must ensure that possible periaortitis is not overlooked.
authors: Department of Thoracic Oncology, Kanagawa Cancer Center Hospital, Japan. murakamis@kcch.jp
authors: Shuji
authors: S
authors: Murakami
authors: Haruhiro
authors: H
authors: Saito
authors: Miki
authors: M
authors: Ohe
authors: Tetsuro
authors: T
authors: Kondo
authors: Fumihiro
authors: F
authors: Oshita
authors: Kouzo
authors: K
authors: Yamada
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D000077192:Adenocarcinoma of Lung; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000009:adverse effects* / Q000096:biosynthesis*; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001025:Aortitis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D000068258:Bevacizumab; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008875:Middle Aged
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab