title: Native kidney BK virus nephropathy associated with acute lymphocytic leukemia.
abstract: BACKGROUND
  Polyoma BK virus nephropathy is a common complication after renal transplantation and is rarely seen in non-renal transplant recipients. There are only a couple of case reports of BK virus nephropathy in native kidneys in non-transplant patients, including a recent report of a 73-year-old patient with chronic lymphatic leukemia. A variety of treatment options, including leflunomide and cidofovir, were reported in these patients.
  
  
  METHODS
  Here we report the case of a 10-year-old boy with acute lymphatic leukemia who presented with non-oliguric hypertensive acute kidney injury at the 12th maintenance cycle of his chemotherapy. The workup supported the clear diagnosis of BK virus nephropathy with tubulointerstitial changes, and the patient responded favorably to intravenous immunoglobulin therapy.
  
  
  CONCLUSIONS
  Pediatric nephrologists need to consider BK virus nephropathy as a differential diagnosis of acute kidney injury in immunocompromised non-transplant patients.
authors: Department of Pathology & Laboratory Medicine, London Health Science Centre-University of Western Ontario, London, ON, Canada. guido.filler@lhsc.on.ca
authors: Guido
authors: G
authors: Filler
authors: Christoph
authors: C
authors: Licht
authors: Aaron
authors: A
authors: Haig
mesh_terms: D001739:BK Virus; D002648:Child; D006801:Humans; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology*; D008297:Male; D027601:Polyomavirus Infections / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D014412:Tumor Virus Infections / Q000209:etiology*