title: Protective potential of Black grapes against lead induced oxidative stress in rats.
abstract: From time immemorial Vitis vinifera (Black grapes) have been used both for medicinal and nourishment purposes. The aim of this study is to investigate the protective effect of Black grapes against lead nitrate induced oxidative stress. Exposure to lead significantly increased malondialdehyde levels with a significant decrease in superoxide dismutase and catalase activities, and the concentration of GSH in the liver and kidneys of rats. Significantly increased levels of AST, ALT, ALP, BUN and serum creatinine and decreased levels of total protein were observed. The administration of lead significantly decreased the body weight and organ weights at the end of the experimental period. Statistically significant decrease in hemoglobin, red blood cell and total leukocyte count was observed. Pretreatment of hydroalcoholic extract of Black grapes to lead exposed rats significantly ameliorated lead-induced oxidative stress in tissues and produced improvement in hematological parameters over lead-exposed rats, indicating the beneficial role of Black grapes to counteract the lead-induced oxidative stress.
authors: Department of Pharmacology, Malla Reddy College of Pharmacy, Dhulapally (via Hakimpet), Maisammaguda, Secunderabad 500014, Andhra Pradesh, India. lakshmi_saineha@yahoo.com
authors: B V S
authors: BV
authors: Lakshmi
authors: M
authors: M
authors: Sudhakar
authors: M
authors: M
authors: Aparna
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D002374:Catalase / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D004785:Environmental Pollutants / Q000633:toxicity*; D004906:Erythrocyte Count; D005978:Glutathione / Q000378:metabolism; D006454:Hemoglobins / Q000032:analysis; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007854:Lead / Q000633:toxicity*; D007958:Leukocyte Count; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009566:Nitrates / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D027843:Vitis
chemical_list: D000975:Antioxidants; D004785:Environmental Pollutants; D006454:Hemoglobins; D009566:Nitrates; D010936:Plant Extracts; D007854:Lead; D008315:Malondialdehyde; C017461:lead nitrate; D003404:Creatinine; D002374:Catalase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005978:Glutathione