title: Survey of human papillomavirus types and their vertical transmission in pregnant women.
abstract: BACKGROUND
  The prevalence, genotypes, and vertical transmission characteristics of human papillomavirus (HPV) among pregnant women from Nanjing, China was investigated.
  
  
  METHODS
  Cervical cells were collected from healthy pregnant women (n = 3139; stage of gestation, 24.6 ± 2.1 weeks) for cytological evaluation and determination of HPV infection status. Exfoliated oral and genital cells were collected from neonates (<1-day-old, n = 233) whose mothers were positive for HPV DNA. We used HPV Gene Chip technology with 23 HPV genotype probes to conduct our analysis.
  
  
  RESULTS
  Overall prevalence of HPV DNA among pregnant women was 13.4% (422/3139). The most frequently detected HPV genotypes were HPV-16 (29.6%, 125/422), -18 (14.7%, 62/422), and -58 (14.2%, 60/422). The rate of concordance for HPV DNA in maternal-neonatal pairs was 23.6% (55/233), with HPV type-specific concordance occurring in 26 cases. A higher prevalence of HPV DNA was apparent in female neonates compared with males (17.7 vs. 11.6%).
  
  
  CONCLUSIONS
  The prevalence of cervical HPV DNA in pregnant women from Nanjing was low, with vertical transmission rates slightly higher. From our findings, we concluded that there was efficient vertical transmission of three HPV genotypes, with HPV-16 the most prevalent type in pregnant women and newborn babies.
authors: Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China. hongyingwjm@sina.com
authors: Ying
authors: Y
authors: Hong
authors: Shu-Qin
authors: SQ
authors: Li
authors: Ya-Li
authors: YL
authors: Hu
authors: Zhi-Qun
authors: ZQ
authors: Wang
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000145:classification / Q000302:isolation & purification*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000473:pathology / Q000635:transmission* / Q000821:virology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult