title: Genetic susceptibility to non-necrotizing erysipelas/cellulitis.
abstract: BACKGROUND
  Bacterial non-necrotizing erysipelas and cellulitis are often recurring, diffusely spreading infections of the skin and subcutaneous tissues caused most commonly by streptococci. Host genetic factors influence infection susceptibility but no extensive studies on the genetic determinants of human erysipelas exist.
  
  
  METHODS
  We performed genome-wide linkage with the 10,000 variant Human Mapping Array (HMA10K) array on 52 Finnish families with multiple erysipelas cases followed by microsatellite fine mapping of suggestive linkage peaks. A scan with the HMA250K array was subsequently performed with a subset of cases and controls.
  
  
  RESULTS
  Significant linkage was found at 9q34 (nonparametric multipoint linkage score (NPL(all)) 3.84, p=0.026), which is syntenic to a quantitative trait locus for susceptibility to group A streptococci infections on chromosome 2 in mouse. Sequencing of candidate genes in the 9q34 region did not conclusively associate any to erysipelas/cellulitis susceptibility. Suggestive linkage (NPL(all)>3.0) was found at three loci: 3q22-24, 21q22, and 22q13. A subsequent denser genome scan with the HMA250K array supported the 3q22 locus, in which several SNPs in the promoter of AGTR1 (Angiotensin II receptor type I) suggestively associated with erysipelas/cellulitis susceptibility.
  
  
  CONCLUSIONS
  Specific host genetic factors may cause erysipelas/cellulitis susceptibility in humans.
authors: Department of Medical Genetics, University of Helsinki, and Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland. katariina.hannula@helsinki.fi
authors: Katariina
authors: K
authors: Hannula-Jouppi
authors: Satu
authors: S
authors: Massinen
authors: Tuula
authors: T
authors: Siljander
authors: Siru
authors: S
authors: Mäkelä
authors: Katja
authors: K
authors: Kivinen
authors: Rasko
authors: R
authors: Leinonen
authors: Hong
authors: H
authors: Jiao
authors: Päivi
authors: P
authors: Aitos
authors: Matti
authors: M
authors: Karppelin
authors: Jaana
authors: J
authors: Vuopio
authors: Jaana
authors: J
authors: Syrjänen
authors: Juha
authors: J
authors: Kere
mesh_terms: D000818:Animals; D002481:Cellulitis / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D004886:Erysipelas / Q000235:genetics*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D051379:Mice; D018895:Microsatellite Repeats / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D010375:Pedigree; D020161:Physical Chromosome Mapping; D015203:Reproducibility of Results
chemical_list: D005819:Genetic Markers