title: Radiotherapy for inverted papilloma: a case report and review of the literature.
abstract: BACKGROUND
  Sinonasal inverted papilloma (IP) is a rare, usually benign tumor arising from the respiratory mucosa of the sinonasal tract. Surgical resection is the treatment of choice. In histologically overt benign IPs (i.e. without associated malignancy) irradiation was employed only anecdotally. The patient with gross residual of benign IP after up-front surgery that was subsequently treated with irradiation is presented and the literature reports on the use of radiotherapy (RT) in this tumor type are reviewed.
  
  
  METHODS
  After the surgical treatment the residuum in the region of the sphenoid and adjacent cavernous sinus was irradiated to 54 Gy in 1.8 Gy daily fractions. No recurrence or deterioration of olfaction, hearing or vision was observed 2.6 years post-RT.
  
  
  METHODS
  In the literature, six reports were identified with 16 patients describing necessary details on RT and outcome. Twelve of 14 cases (our case included) with gross or subtotal tumor resection and postoperative RT were locally controlled. The lowest and the median irradiation doses were 47.15 Gy and 56.5 Gy, respectively, and the follow-up period ranged between 0.5-20.5 years (median 7.8 years).
  
  
  CONCLUSIONS
  RT is safe and valuable treatment option in histologically overt benign IPs. It is indicated when the risk of tumor recurrence after surgery is increased and in inoperable tumors.
authors: Department of Radiation Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
authors: Primoz
authors: P
authors: Strojan
authors: Simona
authors: S
authors: Jereb
authors: Imre
authors: I
authors: Borsos
authors: Jasna
authors: J
authors: But-Hadzic
authors: Nina
authors: N
authors: Zidar
keywords: inverted papilloma; local control; radiotherapy; surgery