title: [Chromosomal aberrations and genetic polymorphism in genes of the xenobiotic detoxification and DNA repair enzymes in thermoelectric power plant employers].
abstract: The results of the investigation of the interrelationship between frequency of chromosomal aberrations and detoxification enzymes (GSTM1, GSTT1) and DNA repair (hOGG1, XPD) genes in the employees of fuel energy complex in Kemerovo are presented In the group of the workers frequency of metaphases with aberrations (3,9 +/- 0,2%: n = 288) was shown to be significantly higher than in the comparison group (2,1 0, 2%: n = +/- 141). In the group of workers and control donors statistically significant differences were revealed in the frequency of distribution of the GSTT1 and hOGG1 genes. The level of chromosomal aberrations was established to be higher in patients with GSTM1 genotype "0/0" in the group of control donors.
authors: Ia A
authors: IaA
authors: Savchenko
authors: V I
authors: VI
authors: Minina
authors: M L
authors: ML
authors: Bakanova
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000493:pharmacokinetics / Q000633:toxicity*; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000139:chemically induced* / Q000706:statistics & numerical data; D045647:DNA Glycosylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008658:Inactivation, Metabolic; D011110:Polymorphism, Genetic; D011210:Power Plants / Q000592:standards; D060888:Real-Time Polymerase Chain Reaction; D015262:Xenobiotics / Q000493:pharmacokinetics / Q000633:toxicity*; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics
chemical_list: D000395:Air Pollutants, Occupational; D045647:DNA Glycosylases; D045643:DNA Repair Enzymes; D005982:Glutathione Transferase; D015262:Xenobiotics; D051759:Xeroderma Pigmentosum Group D Protein; C413545:glutathione S-transferase T1; C479058:oxoguanine glycosylase 1, human; C497292:ERCC2 protein, human