title: Role of the coagulation system in development.
abstract: The generation of knock out mice urged researchers, not always voluntarily, to newly define developmental functions of the gene knocked out. Among others, this has led to the establishment of the field of developmental haemostasis. The work in this field identified a role of coagulation proteases and their regulators independent of haemostasis in the embryo proper. Rather, coagulation proteases regulate cellular function through receptor dependent signalling in the embryo proper, both within and outside the vasculature. Likewise, coagulation proteases modulate placental development independent of haemostasis through mechanisms involving the activation of maternal myeloid derived cells. The following review summarizes the current knowledge in the field of developmental haemostasis and pinpoints open questions within this evolving field.
authors: Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany.
authors: Muhammed
authors: M
authors: Kashif
authors: Berend
authors: B
authors: Isermann
mesh_terms: D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000737:chemistry; D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism; D002319:Cardiovascular System / Q000196:embryology*; D005260:Female; D006487:Hemostasis; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D010920:Placenta / Q000098:blood supply*; D010929:Placentation; D011247:Pregnancy; D011270:Pregnancy, Animal; D044462:Receptors, Proteinase-Activated; D015398:Signal Transduction; D014327:Trophoblasts / Q000502:physiology
chemical_list: D017152:Antibodies, Antiphospholipid; D044462:Receptors, Proteinase-Activated