title: Anthropometric factors in relation to risk of glioma.
abstract: BACKGROUND
  Increased height and greater adiposity have been linked to an increased risk of many cancer types, though few large studies have examined these associations in glioma. We examined body weight and height as potential risk factors for glioma in a large US-based case-control study.
  
  
  METHODS
  The analysis included 1,111 glioma cases and 1,096 community controls. In a structured interview, participants reported their height and weight at 21 years of age, lowest and highest weight in adulthood, and weight 1-5 years in the past.
  
  
  RESULTS
  Being underweight at age 21 (BMI < 18.5 kg/m(2)) was inversely associated with the risk of glioma development. This protective association was observed in both men and women, but reached statistical significance in women only (multivariate OR 0.68; 95 % CI 0.48, 0.96). When BMI at age 21 was assessed as a continuous variate, a small but significant increase in risk was observed per unit increase in kg/m(2) (OR 1.04; 95 % CI 1.02, 1.07). Adult height, recent body weight, and weight change in adulthood were not associated with glioma risk. All results were similar among never smokers and were consistent after stratifying by glioma subtype.
  
  
  CONCLUSIONS
  The present data suggest that a low body weight in early adulthood is associated with a reduced risk of glioma later in life. Results are consistent with previous studies in showing no material association of glioma risk with usual adult body weight. The present study does not support any association of adult stature with glioma risk.
authors: Neuro-oncology Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors: Rebecca B
authors: RB
authors: Little
authors: Melissa H
authors: MH
authors: Madden
authors: Reid C
authors: RC
authors: Thompson
authors: Jeffrey J
authors: JJ
authors: Olson
authors: Renato V
authors: RV
authors: Larocca
authors: Edward
authors: E
authors: Pan
authors: James E
authors: JE
authors: Browning
authors: Kathleen M
authors: KM
authors: Egan
authors: L Burton
authors: LB
authors: Nabors
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D001827:Body Height; D001835:Body Weight; D016022:Case-Control Studies; D016543:Central Nervous System Neoplasms / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005910:Glioma / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment