title: A case of anaplastic lymphoma kinase-positive large B-cell lymphoma: aspiration cytology findings.
abstract: Anaplastic lymphoma kinase-positive (ALK+) large B-cell lymphoma (LBCL) is a rare subtype of non-Hodgkin B-cell lymphoma that exhibits a more aggressive clinical course and poorer prognosis than the typical diffuse large B-cell lymphoma. In this study, we report the case of a 67-year-old man with left cervical lymph node swelling. Aspiration cytology revealed many clusters of cohesive, large, and solitary cells. The tumor cells had abundant cytoplasm and large round-to-oval nuclei with prominent nucleoli. The Giemsa staining specimens exhibited amorphous global bodies adjacent to some clusters. Histologically, large tumor cells occupied the lymph nodes in a sinusoidal pattern, and immunohistochemically, these cells were cytokeratin-, CD19(-), CD20(-), CD79a(-), CD3(-), CD30(-), CD138(+), IgG(-), IgA(+), and ALK(+). Chromogenic in situ hybridization revealed restricted immunoglobulin light-chain expression. Fluorescent in situ hybridization demonstrated translocation of the ALK gene. The tumor cells were negative for Epstein-Barr virus and human herpesvirus 8. It is important to differentiate ALK+LBCL from metastatic carcinoma and other lymphoma subtypes with similar histological features to ensure a proper treatment strategy and prediction of prognosis.
authors: Department of Pathology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.
authors: Shin-ichi
authors: S
authors: Nakatsuka
authors: Kazuko
authors: K
authors: Oku
authors: Teruaki
authors: T
authors: Nagano
authors: Hayato
authors: H
authors: Kimura
authors: Atsushi
authors: A
authors: Hanamoto
authors: Mahito
authors: M
authors: Ito
authors: Koji
authors: K
authors: Hashimoto
mesh_terms: D000368:Aged; D000077548:Anaplastic Lymphoma Kinase; D001707:Biopsy, Needle; D006801:Humans; D016393:Lymphoma, B-Cell / Q000737:chemistry* / Q000201:enzymology / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008297:Male; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis* / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: anaplastic lymphoma kinase; aspiration cytology; cohesiveness; large B-cell lymphoma