title: Determinants of microdamage in elderly human vertebral trabecular bone.
abstract: Previous studies have shown that microdamage accumulates in bone as a result of physiological loading and occurs naturally in human trabecular bone. The purpose of this study was to determine the factors associated with pre-existing microdamage in human vertebral trabecular bone, namely age, architecture, hardness, mineral and organic matrix. Trabecular bone cores were collected from human L2 vertebrae (n = 53) from donors 54-95 years of age (22 men and 30 women, 1 unknown) and previous cited parameters were evaluated. Collagen cross-link content (PYD, DPD, PEN and % of collagen) was measured on surrounding trabecular bone. We found that determinants of microdamage were mostly the age of donors, architecture, mineral characteristics and mature enzymatic cross-links. Moreover, linear microcracks were mostly associated with the bone matrix characteristics whereas diffuse damage was associated with architecture. We conclude that linear and diffuse types of microdamage seemed to have different determinants, with age being critical for both types.
authors: INSERM, UMR 1033, Lyon, France. Helene.Follet@inserm.fr
authors: Hélène
authors: H
authors: Follet
authors: Delphine
authors: D
authors: Farlay
authors: Yohann
authors: Y
authors: Bala
authors: Stéphanie
authors: S
authors: Viguet-Carrin
authors: Evelyne
authors: E
authors: Gineyts
authors: Brigitte
authors: B
authors: Burt-Pichat
authors: Julien
authors: J
authors: Wegrzyn
authors: Pierre
authors: P
authors: Delmas
authors: Georges
authors: G
authors: Boivin
authors: Roland
authors: R
authors: Chapurlat
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D002113:Calcification, Physiologic; D003094:Collagen / Q000032:analysis; D005260:Female; D006244:Hardness; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000032:analysis; D013131:Spine / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D008903:Minerals; D003094:Collagen