title: Viscoelastic properties of fibrinogen adsorbed onto poly(ethylene terephthalate) surfaces by QCM-D.
abstract: In presented study a new approach using QCM-D for biocompatibility determination was introduced. The adsorption of fibrinogen on PET and modified PET surfaces was monitored in situ using QCM-D. Protein layer thicknesses were estimated on the basis of a Voight based viscoelastic model. The hydrophilicities and morphologies of the surfaces were investigated using a goniometer and AFM. The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. QCM-D equipped with QTools modelling software is well-applicable to the characterisation of surface properties and can be optimised for biocompatibility determination.
authors: Laboratory for Characterization and Processing of Polymers, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia. ales.doliska@uni-mb.si
authors: Aleš
authors: A
authors: Doliška
authors: Volker
authors: V
authors: Ribitsch
authors: Karin
authors: K
authors: Stana Kleinschek
authors: Simona
authors: S
authors: Strnad
mesh_terms: D000327:Adsorption; D000925:Anticoagulants / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D005340:Fibrinogen / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing / Q000379:methods; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D011092:Polyethylene Glycols / Q000737:chemistry*; D011093:Polyethylene Terephthalates; D011134:Polysaccharides / Q000737:chemistry; D058525:Quartz Crystal Microbalance Techniques / Q000379:methods*; D012984:Software; D013499:Surface Properties; D055682:Viscoelastic Substances / Q000032:analysis* / Q000737:chemistry
chemical_list: D000925:Anticoagulants; D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D011134:Polysaccharides; D055682:Viscoelastic Substances; D011092:Polyethylene Glycols; D005340:Fibrinogen