title: Influence of a 100-km ultra-marathon on hepatitis B carrier runners.
abstract: This study compares the serological markers between runners who are hepatitis B virus carries (HBVc) and runners who are non-HBVc in a 100-km ultra-marathon race. Blood samples of 8 HBVc and 18 non-HBVc runners were drawn 1 week before, immediately following, and 24 h after the race. Samples were analyzed and compared between the 2 groups for liver function tests, muscle damage markers and oxidative stress cytokines. For HBVc runners, HBV-DNA (hepatitis B virus-deoxyribonucleic acid) levels were also evaluated for virus reactivation. The results demonstrate a statistically significant increase in both immediate and 24-h post-race values for alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), compared with pre-race values. No statistically significant difference was observed between the 2 groups for the values of AST, LDH, CK, hs-CRP, IL-6 and TNF-α either before or after the race. There was also no statistically significant change in the levels of HBV-DNA in HBVc runners. These findings suggest that HBVc runners do not have higher risks of liver function impairment, muscle breakdown and inflammatory response compared to non-HBVc runners in such endurance races.
authors: Department of Emergency Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors: Y-H
authors: YH
authors: Chiu
authors: S-K
authors: SK
authors: Hou
authors: C-K
authors: CK
authors: How
authors: L-H
authors: LH
authors: Li
authors: W-F
authors: WF
authors: Kao
authors: C-C
authors: CC
authors: Yang
authors: S-L
authors: SL
authors: Chou
authors: Y-T S
authors: YT
authors: Shiau
authors: C
authors: C
authors: Lam
authors: R-J
authors: RJ
authors: Chen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002353:Carrier State; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism; D004279:DNA, Viral / Q000378:metabolism; D005260:Female; D006509:Hepatitis B / Q000821:virology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008099:Liver / Q000378:metabolism* / Q000821:virology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010807:Physical Endurance / Q000502:physiology; D012420:Running / Q000502:physiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D004279:DNA, Viral