title: Monetary reward processing in obese individuals with and without binge eating disorder.
abstract: BACKGROUND
  An important step in obesity research involves identifying neurobiological underpinnings of nonfood reward processing unique to specific subgroups of obese individuals.
  
  
  METHODS
  Nineteen obese individuals seeking treatment for binge eating disorder (BED) were compared with 19 non-BED obese individuals (OB) and 19 lean control subjects (LC) while performing a monetary reward/loss task that parses anticipatory and outcome components during functional magnetic resonance imaging. Differences in regional activation were investigated in BED, OB, and LC groups during reward/loss prospect, anticipation, and notification.
  
  
  RESULTS
  Relative to the LC group, the OB group demonstrated increased ventral striatal and ventromedial prefrontal cortex activity during anticipatory phases. In contrast, the BED group relative to the OB group demonstrated diminished bilateral ventral striatal activity during anticipatory reward/loss processing. No differences were observed between the BED and LC groups in the ventral striatum.
  
  
  CONCLUSIONS
  Heterogeneity exists among obese individuals with respect to the neural correlates of reward/loss processing. Neural differences in separable groups with obesity suggest that multiple, varying interventions might be important in optimizing prevention and treatment strategies for obesity.
authors: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors: Iris M
authors: IM
authors: Balodis
authors: Hedy
authors: H
authors: Kober
authors: Patrick D
authors: PD
authors: Worhunsky
authors: Marney A
authors: MA
authors: White
authors: Michael C
authors: MC
authors: Stevens
authors: Godfrey D
authors: GD
authors: Pearlson
authors: Rajita
authors: R
authors: Sinha
authors: Carlos M
authors: CM
authors: Grilo
authors: Marc N
authors: MN
authors: Potenza
mesh_terms: D000328:Adult; D056912:Binge-Eating Disorder / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology; D009765:Obesity / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D012201:Reward