title: T cell co-stimulatory molecules: a co-conspirator in the pathogenesis of eosinophilic esophagitis?
abstract: Eosinophilic esophagitis (EoE) has become a common gastrointestinal disease. It is characterized by severe eosinophil infiltration in the esophagus. EoE is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. Recent studies have shown that the ligation of co-stimulatory molecules contributes to the activation, differentiation, and proliferation of T cells. In this review, we will discuss the growing evidence of co-stimulatory molecules including OX40, Light, and HVEM in the pathogenesis of Th2-driven EoE. Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules.
authors: Department of Pediatrics, Case Western Reserve University School of Medicine, 11000 Euclid Avenue, Cleveland, OH 44106, USA. zili.zhang@uhhospitals.org
authors: Zili
authors: Z
authors: Zhang
authors: Thomas J
authors: TJ
authors: Sferra
authors: Yasemen
authors: Y
authors: Eroglu
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D057765:Eosinophilic Esophagitis / Q000235:genetics / Q000276:immunology*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008213:Lymphocyte Activation; D053262:Receptors, OX40 / Q000378:metabolism*; D053240:Receptors, Tumor Necrosis Factor, Member 14 / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14 / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D053262:Receptors, OX40; D053240:Receptors, Tumor Necrosis Factor, Member 14; C506028:TNFRSF14 protein, human; C505716:TNFRSF4 protein, human; C505914:TNFSF14 protein, human; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14