title: PAI-1 4G/5G polymorphism contributes to cancer susceptibility: evidence from meta-analysis.
abstract: BACKGROUND
  The plasminogen activator inhibitor-1 (PAI-1) is expressed in many cancer cell types and allows the modulation of cancer growth, invasion and angiogenesis. To date, studies investigated the association between a functional polymorphism in PAI-1 (4G/5G) and risk of cancer have shown inclusive results.
  
  
  METHODS
  A meta-analysis based on 25 case-control studies was performed to address this issue. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. The statistical heterogeneity across studies was examined with I(2) test.
  
  
  RESULTS
  Overall, a significant increased risk of cancer was associated with the PAI-1 4G/4G polymorphism for the allele contrast (4G vs. 5G: OR = 1.10, CI = 1.03-1.18, I(2) = 49.5%), the additive genetic model (4G/4G vs. 5G/5G: OR = 1.21, CI = 1.06-1.39, I(2) = 51.9%), the recessive genetic model (4G/4G vs. 4G/5G+5G/5G: OR = 1.11, CI = 1.04-1.18, I(2) = 20.8%). In the subgroup analysis by ethnicity, the results indicated that individuals with 4G/4G genotype had a significantly higher cancer risk among Caucasians (4G/4G vs. 5G/5G: OR = 1.31, 95%CI = 1.09-1.59, I(2) = 59.6%; 4G/4G vs. 4G/5G: OR = 1.12, 95%CI = 1.04-1.21, I(2) = 3.6%; recessive model: OR = 1.12, 95%CI = 1.05-1.21, I(2) = 25.3%).
  
  
  CONCLUSIONS
  The results of the present meta-analysis support an association between the PAI-1 4G/5G polymorphism and increasing cancer risk, especially among Caucasians, and those with 4G allele have a high risk to develop colorectal cancer and endometrial cancer.
authors: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: Shangqian
authors: S
authors: Wang
authors: Qiang
authors: Q
authors: Cao
authors: Xiaoxiang
authors: X
authors: Wang
authors: Bingjie
authors: B
authors: Li
authors: Min
authors: M
authors: Tang
authors: Wanqing
authors: W
authors: Yuan
authors: Jianzheng
authors: J
authors: Fang
authors: Jian
authors: J
authors: Qian
authors: Chao
authors: C
authors: Qin
authors: Wei
authors: W
authors: Zhang
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D017395:Plasminogen Activator Inhibitor 1