title: Antityrosinase and antimicrobial activities of furfuryl alcohol, furfural and furoic acid.
abstract: The inhibitory kinetics of furfuryl alcohol, furfural and furoic acid on mushroom tyrosinase have been investigated. The results showed that these furan compounds were reversible inhibitors of the enzyme. Furthermore, furfuryl alcohol and furfural were found to be mixed-type inhibitors while furoic acid is uncompetitive inhibitor. The inhibition constants have been confirmed and the order of the inhibiting ability was furfural>furoic acid>furfuryl alcohol. They indicate that the functional groups on the furan ring play a crucial role in the inhibition on the enzyme. In addition, it was also found that these furan compounds could inhibit the proliferation of Salmonella bacteria and Bacillus subtilis to different extents. The minimum inhibitory concentration (MIC) values of furfuryl alcohol, furfural and furoic acid against B. subtilis and S. bacteria were 0.115, 0.027, 0.015 and 0.115, 0.029, 0.009 μM, respectively. The minimum bactericidal concentration (MBC) values of that were 0.115, 0.027, 0.015 and 0.231, 0.121, 0.030 μM, respectively.
authors: School of Life Sciences, Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems, Xiamen University, Xiamen 361005, China.
authors: Wei-Ming
authors: WM
authors: Chai
authors: Xuan
authors: X
authors: Liu
authors: Yong-Hua
authors: YH
authors: Hu
authors: Hui-Ling
authors: HL
authors: Feng
authors: Yu-Long
authors: YL
authors: Jia
authors: Yun-Ji
authors: YJ
authors: Guo
authors: Han-Tao
authors: HT
authors: Zhou
authors: Qing-Xi
authors: QX
authors: Chen
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000254:growth & development*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005656:Fungal Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D005662:Furaldehyde / Q000737:chemistry / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000494:pharmacology*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D012475:Salmonella / Q000254:growth & development*
chemical_list: D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D005656:Fungal Proteins; D005663:Furans; C012986:furfuryl alcohol; D005662:Furaldehyde; D014442:Monophenol Monooxygenase