title: The effect of ergocalciferol on uremic pruritus severity: a randomized controlled trial.
abstract: OBJECTIVE
  Hemodialysis (HD) patients have a high prevalence of pruritus. 25-Hydroxy vitamin D deficiency is common in this population and may play a role in its etiology. Because of this, we studied whether vitamin D2 treatment with ergocalciferol is effective for relief of uremic pruritus severity as measured by pruritus severity surveys.
  
  
  METHODS
  In this double-blind, placebo-controlled, randomized trial, the effect of 12 weeks of ergocalciferol administration on uremic pruritus severity was evaluated.
  
  
  METHODS
  Fifty HD patients randomly received either ergocalciferol 50,000 international units (IU) or placebo once weekly for 12 weeks.
  
  
  METHODS
  Pruritus severity surveys were completed every 2 weeks by all patients starting from baseline until 12 weeks and serve as the main outcome variable.
  
  
  RESULTS
  Twenty-five study participants were randomized to ergocalciferol therapy and 25 were randomized to placebo. At baseline, the only significant difference between the two groups was time on dialysis and white blood cell count. Both groups experienced a decrease in pruritus scores from the beginning to the end of study (percent change -38.9% in the treatment group vs. -47.5% in the placebo group). By intention to treat, the treatment × time effect was not statistically significant (F = 0.71, df = (1, 282), P = .34), indicating that the pruritus score was not significantly lower in the treatment group than the placebo group throughout the study.
  
  
  CONCLUSIONS
  In conclusion, we did not find ergocalciferol to be effective for the treatment of uremic pruritus.
authors: Division of Nephrology, Winthrop University Hospital, Mineola, New York, USA. sshirazian@winthrop.org
authors: Shayan
authors: S
authors: Shirazian
authors: Mary
authors: M
authors: Schanler
authors: Shuba
authors: S
authors: Shastry
authors: Shaunak
authors: S
authors: Dwivedi
authors: Maanvi
authors: M
authors: Kumar
authors: Kathleen
authors: K
authors: Rice
authors: Nobuyuki
authors: N
authors: Miyawaki
authors: Samiran
authors: S
authors: Ghosh
authors: Steven
authors: S
authors: Fishbane
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D004872:Ergocalciferols / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010352:Patient Dropouts; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis / Q000009:adverse effects; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D004872:Ergocalciferols