title: [Expression of survivin in rheumatoid arthritis].
abstract: OBJECTIVE
  To detect the correlation between survivin and rheumatoid arthritis (RA) to determine the possible mechanism of RA and multidrug resistance in refractory rheumatoid arthritis (RRA).
  
  
  METHODS
  We collected 15 normal controls, 35 early untreated RA patients, 20 effectively treated RA patients and 25 RRA patients according to selection standard. The expression of survivin in the peripheral blood lymphocytes was detected by immunocytochemical method.
  
  
  RESULTS
  There was significant difference in the survivin expression in the peripheral blood lymphocytes between the early untreated and normal control group (χ(2)=29.59, P<0.01). The survivin expression in the peripheral blood lymphocytes of effectively treated RA group slightly elevated, but had no significant difference with the normal control group (χ(2)=1.591, P>0.05). The survivin expression in the peripheral blood lymphocytes of the RRA group was significantly stronger than in the effectively treated RA group (χ(2)=24.35, P<0.01), and normal control group (χ(2)=26.53, P<0.01), with no significant difference compared with early untreated group (χ(2)=0.014,P>0.05).
  
  
  CONCLUSIONS
  Survivin has an influential role in the occurrence and development of rheumatism arthritis. Survivin might be involved in refractory multidrug resistance of RA and be one of the multidrug resistance mechanism of RRA.
authors: Department of Rheumatology, Central South University, Changsha, China. jinwei73104@yahoo.com.cn
authors: Jinwei
authors: J
authors: Chen
authors: Ming
authors: M
authors: Liu
authors: Ni
authors: N
authors: Mao
authors: Yan
authors: Y
authors: Zeng
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism*; D016022:Case-Control Studies; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D000077022:Survivin; D055815:Young Adult
chemical_list: D018501:Antirheumatic Agents; C107489:BIRC5 protein, human; D007166:Immunosuppressive Agents; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin