title: Incidence of sexually transmitted infections in HIV-infected and HIV-uninfected adolescents in the USA.
abstract: Little is known about the incidence of bacterial sexually transmitted infections (STIs) among HIV-infected versus HIV-uninfected adolescents. This secondary analysis of a national, multisite study included adolescents aged 12-18 years who were behaviourally HIV-infected (n = 346) or HIV-uninfected but at-risk (n = 182). Incidence rates of bacterial STIs (gonorrhoea, chlamydia [CT] and trichomonas [TV; women]) were calculated using Poisson modelling. Factors associated with incident STIs were explored using Cox proportional hazards modelling. HIV-infected versus HIV-uninfected women had higher TV incidence (1.3 versus 0.6/100 person-months; P = 0.002). HIV-uninfected versus HIV-infected women had higher CT incidence (1.6 versus 1.1/100 person-months; P = 0.04). Among women, demographic, behavioural and HIV-related factors were associated with incident STIs. Among men, there were no differences in incident STIs. In this first analysis comparing STI incidence between HIV-infected and HIV-uninfected adolescents, bacterial STI incidence among women significantly differed by HIV status, and factors associated with incident STIs varied by STI and HIV status.
authors: Division of Adolescent Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center.
authors: T L K
authors: TL
authors: Mullins
authors: B J
authors: BJ
authors: Rudy
authors: C M
authors: CM
authors: Wilson
authors: H
authors: H
authors: Sucharew
authors: J A
authors: JA
authors: Kahn
mesh_terms: D000293:Adolescent; D002648:Child; D002690:Chlamydia Infections / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006069:Gonorrhea / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D018023:HIV Seronegativity; D006801:Humans; D015994:Incidence; D007407:Interviews as Topic; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012307:Risk Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D014245:Trichomonas Infections / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D014481:United States / Q000453:epidemiology
keywords: HIV; STI; adolescent; incidence; risk factors; sexually transmitted infection