title: Adenoid cystic carcinoma of the head and neck: clinicopathologic analysis of 218 cases in a Chinese population.
abstract: OBJECTIVE
  The aim of this study was to analyze the clinicopathologic characteristics and prognostic factors of adenoid cystic carcinoma of the head and neck (ACCHN).
  
  
  METHODS
  This was a retrospective study of 218 patients with ACCHN.
  
  
  RESULTS
  The cohort included 110 men and 108 women; the parotid and the palate were the most common site of involvement. Of 203 patients with follow-up information (range 2-132 months), 57 had died of the tumor. Distant metastasis (DM) and local recurrence (LR) were documented in 83 (40.9%) and 34 (16.7%) patients, respectively. Cox regression analysis indicated that a solid pattern was a marker for LR and that positive margins and older age were risk factors for DM. Histologic pattern, T stage, N stage, LR, DM, and patient age contributed to the prediction of disease-specific survival.
  
  
  CONCLUSIONS
  A solid pattern, metastasis, LR, and older age are the most important factors for predicting poor prognosis in Chinese patients with ACCHN.
authors: Department of Oral Pathology, 9th People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors: Chun-Ye
authors: CY
authors: Zhang
authors: Rong-Hui
authors: RH
authors: Xia
authors: Jing
authors: J
authors: Han
authors: Bing-Shun
authors: BS
authors: Wang
authors: Wei-Dong
authors: WD
authors: Tian
authors: Lai-Ping
authors: LP
authors: Zhong
authors: Zhen
authors: Z
authors: Tian
authors: Li-Zhen
authors: LZ
authors: Wang
authors: Yu-Hua
authors: YH
authors: Hu
authors: Jiang
authors: J
authors: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology* / Q000556:secondary; D002423:Cause of Death; D002681:China; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D010157:Palatal Neoplasms / Q000473:pathology; D010307:Parotid Neoplasms / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000473:pathology; D055815:Young Adult