title: Palladium-catalyzed synthesis of N-aryl carbamates.
abstract: An efficient synthesis of aryl carbamates was achieved by introducing alcohols into the reaction of palladium-catalyzed cross-coupling of ArX (X = Cl, OTf) with sodium cyanate. The use of aryl triflates as electrophilic components in this transformation allowed for an expanded substrate scope for direct synthesis of aryl isocyanates. This methodology provides direct access to major carbamate protecting groups, S-thiocarbamates, and diisocyanate precursors to polyurethane materials.
authors: Massachusetts Institute of Technology, Department of Chemistry, Cambridge, Massachusetts 02139, USA.
authors: Ekaterina V
authors: EV
authors: Vinogradova
authors: Nathaniel H
authors: NH
authors: Park
authors: Brett P
authors: BP
authors: Fors
authors: Stephen L
authors: SL
authors: Buchwald
mesh_terms: D000438:Alcohols / Q000737:chemistry; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003485:Cyanates / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D002219:Carbamates; D003485:Cyanates; D010165:Palladium; C009281:sodium cyanate