title: The COBLL1 C allele is associated with lower serum insulin levels and lower insulin resistance in overweight and obese children.
abstract: BACKGROUND
  Childhood obesity is a growing epidemic worldwide, and it is associated with metabolic complications, such as insulin resistance. Recently, a genetic variation (rs7607980) in the COBLL1 gene has been associated with lower insulin resistance in adults. The aim of the study was to investigate if the association between COBLL1 rs7607980 genetic variant and lower insulin resistance was present early in life.
  
  
  METHODS
  This sequence variant was genotyped in 878 overweight and obese children (mean age: 10 years) from Sardinia, Italy, from the outpatient clinic of the Pediatric Endocrine Unit, at the Regional Hospital for Microcitaemia in Cagliari. Insulin resistance was assessed by measurement of fasting circulating insulin levels before and after an oral glucose tolerance test and by HOMA-IR.
  
  
  RESULTS
  The COBLL1 rs7607980 C allele was associated with lower fasting insulin and HOMA-IR levels (p = 0.002 and p = 0.035, respectively) in overweight and obese children. Importantly, lower insulin levels were also observed 2 h after oral glucose tolerance test in C allele carriers (p = 0.009).
  
  
  CONCLUSIONS
  The present study shows for the first time, the association between COBLL1 rs7607980 C allele, lower serum insulin levels and lower insulin resistance in overweight and obese children.
authors: Institute of Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Bruna Stråket 16, Göteborg, Sweden.
authors: Rosellina Margherita
authors: RM
authors: Mancina
authors: Maria Antonella
authors: MA
authors: Burza
authors: Cristina
authors: C
authors: Maglio
authors: Carlo
authors: C
authors: Pirazzi
authors: Federica
authors: F
authors: Sentinelli
authors: Michela
authors: M
authors: Incani
authors: Tiziana
authors: T
authors: Montalcini
authors: Arturo
authors: A
authors: Pujia
authors: Tiziana
authors: T
authors: Congiu
authors: Sandro
authors: S
authors: Loche
authors: Sabrina
authors: S
authors: Pilia
authors: Olov
authors: O
authors: Wiklund
authors: Jan
authors: J
authors: Borén
authors: Stefano
authors: S
authors: Romeo
authors: Marco Giorgio
authors: MG
authors: Baroni
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015536:Down-Regulation; D005260:Female; D056726:Genetic Association Studies; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D007558:Italy; D008297:Male; D009765:Obesity / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D050177:Overweight / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: C584084:COBLL1 protein, human; D007328:Insulin; D014157:Transcription Factors
keywords: COBLL1; children; genetics; insulin resistance; obesity; rs7607980