title: The Saccharomyces cerevisiae RhoGAP Rgd1 is phosphorylated by the Aurora B like kinase Ipl1.
abstract: Polarized growth of the yeast Saccharomyces cerevisiae depends on different biological processes and requires several signaling pathways. Signaling is mediated through a set of proteins, which include Rho3p and Rho4p GTPases. Although these two proteins are involved in the control of distinct aspects of polarized growth in yeast, they have a common regulator: the Rgd1 RhoGAP protein. Here we demonstrate that Rgd1p is phosphorylated by the Aurora B like kinase Ipl1 and we observe that loss of Ipl1 function leads to a new Rgd1p distribution in a small part of the cell population.
authors: Univ. Bordeaux, Institut de Biochimie et Génétique Cellulaires, UMR CNRS 5095, F-33000 Bordeaux, France.
authors: Aurélie
authors: A
authors: Vieillemard
authors: Valérie
authors: V
authors: Prouzet-Mauléon
authors: Michel
authors: M
authors: Hugues
authors: Fabien
authors: F
authors: Lefebvre
authors: Romain
authors: R
authors: Mitteau
authors: Stéphane
authors: S
authors: Claverol
authors: Marc
authors: M
authors: Bonneu
authors: Marc
authors: M
authors: Crouzet
authors: François
authors: F
authors: Doignon
authors: Didier
authors: D
authors: Thoraval
mesh_terms: D064127:Aurora Kinases; D048749:Cytokinesis; D020690:GTPase-Activating Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005800:Genes, Fungal; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020690:GTPase-Activating Proteins; D047908:Intracellular Signaling Peptides and Proteins; C449479:RGD1 protein, S cerevisiae; D011993:Recombinant Fusion Proteins; D029701:Saccharomyces cerevisiae Proteins; D064127:Aurora Kinases; C576961:IPL1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases