title: Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles.
abstract: The low rate of survival for patients diagnosed with glioblastoma may be attributed to the existence of a subpopulation of cancer stem cells. These stem cells have certain properties that enable them to resist chemotherapeutic agents and ionizing radiation. Herein, we show that temozolomide-loaded gold nanostructures are efficient in reducing chemoresistance and destroy 82.7% of cancer stem cells compared with a 42% destruction rate using temozolomide alone. Measurements of in vitro cytotoxicity and apoptosis indicate that combination with gold facilitated the ability of temozolomide, an alkylating drug, to alter the resistance of these cancer stem cells, suggesting a new chemotherapy strategy for patients diagnosed with inoperable recurrent malignant glioma.
authors: Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, Romania.
authors: Anamaria
authors: A
authors: Orza
authors: Olga
authors: O
authors: Soriţău
authors: Ciprian
authors: C
authors: Tomuleasa
authors: Liliana
authors: L
authors: Olenic
authors: Adrian
authors: A
authors: Florea
authors: Ovidiu
authors: O
authors: Pana
authors: Ioan
authors: I
authors: Bratu
authors: Emoke
authors: E
authors: Pall
authors: Stefan
authors: S
authors: Florian
authors: Dan
authors: D
authors: Casciano
authors: Alexandru S
authors: AS
authors: Biris
mesh_terms: D000704:Analysis of Variance; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001224:Aspartic Acid / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D019008:Drug Resistance, Neoplasm; D004355:Drug Stability; D004357:Drug Synergism; D005434:Flow Cytometry; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology; D000077204:Temozolomide
chemical_list: D000970:Antineoplastic Agents; D001224:Aspartic Acid; D006046:Gold; D003606:Dacarbazine; D000077204:Temozolomide
keywords: cancer stem cells; drug delivery; gold nanoparticles; recurrent high-grade gliomas; temozolomide stability; temozolomide therapy