title: Predictive value of health-related quality of life in progression of disability and depression in persons with multiple sclerosis: a 3-year study.
abstract: In our study, we examined whether health-related quality of life (HRQoL) could predict changes in disability, depression, and fatigue in patients with multiple sclerosis (MS) over a 3-year follow-up period. A group of 109 consecutive MS patients (McDonald's criteria) referring to the Institute of Neurology, Belgrade were enrolled in the study. At two time points during the study (baseline, and after a 3-year period) an HRQoL (measured by MSQoL-54), EDSS, Hamilton Rating Scale for Depression (HDRS) and Fatigue Severity Scale (FSS) were assessed. At the end of a 3-year follow-up, 12 out of 109 patients (11%) had dropped out. Multiple linear regression analysis showed that Physical Health scale of MSQoL-54 is significant independent predictor of change in EDSS after 3 years (p = 0.035). Mental health composite score of MSQoL-54 was predictor of change in HDRS score (p = 0.049). In separate regression analysis, only social function was independent predictor of the development of depression (p = 0.041). None of the HRQoL domains had predictive effect on the change of FSS. Our study suggests that baseline HRQoL scores, measured by MSQoL-54, could be applied as a prognostic marker for progression of both, disability, and severity of depressive symptoms in MS.
authors: Faculty of Medicine, Institute of Epidemiology, University of Belgrade, Visegradska 26, 11000, Belgrade, Serbia.
authors: Darija
authors: D
authors: Kisic Tepavcevic
authors: Tatjana
authors: T
authors: Pekmezovic
authors: Nebojsa
authors: N
authors: Stojsavljevic
authors: Jelena
authors: J
authors: Kostic
authors: Irena
authors: I
authors: Dujmovic Basuroski
authors: Sarlota
authors: S
authors: Mesaros
authors: Jelena
authors: J
authors: Drulovic
mesh_terms: D000328:Adult; D003863:Depression / Q000175:diagnosis / Q000209:etiology; D004185:Disability Evaluation; D018450:Disease Progression; D005221:Fatigue / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000523:psychology*; D011237:Predictive Value of Tests; D011788:Quality of Life / Q000523:psychology; D011795:Surveys and Questionnaires; D055815:Young Adult