title: Therapy-related acute myeloid leukemia in a primary pulmonary leiomyosarcoma patient with skin metastasis.
abstract: Primary pulmonary leiomyosarcoma (LMS) is a very unusual tumor. Although LMS has well-known metastatic potential, cutaneous metastasis is a remarkably uncommon. Exposure to cytotoxic agents could lead to "therapy-related myeloid neoplasm" (t-MN). Starting from 2008, the World Health Organization (WHO) has adopted the term to cover the spectrum of malignant diseases previously known as therapy-related acute myeloid leukemia (t-AML), therapy-related myelodysplastic syndrome (t-MDS) and therapy-related myelodysplastic/myelo- proliferative neoplasm (t-MDS/MPN). We described the onset of t-MDS and progression to t-AML in one case diagnosed as primary pulmonary LMS with cutaneous metastasis. This patient achieved complete remission (CR) after three courses of IA regimen chemotherapy (idarubicin 5 mg/d, d 1-3; cytarabine 100 mg/d, d 1-5) and 1 course of HA chemotherapy regimen (homoharringtonine 3 mg/d, d 1-3; cytarabine 100 mg/d, d 1-7). This case presents the natural course of therapy-related neoplasm and provides therapeutic experience for t-AML.
authors: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Yan
authors: Y
authors: Ma
authors: Bo-Bin
authors: BB
authors: Chen
authors: Xiao-Ping
authors: XP
authors: Xu
authors: Guo-Wei
authors: GW
authors: Lin
authors: Yuan
authors: Y
authors: Ji
authors: Sujie
authors: S
authors: Akesu
authors: Haiying
authors: H
authors: Zen
keywords: Leiomyosarcoma; Metastasis; Skin; Therapy-related acute myeloid leukemia; Therapy-related myelodysplastic syndrome