title: Plasma phospholipid trans fatty acids and risk of heart failure.
abstract: BACKGROUND
  Although trans fatty acids (TFAs) may increase the risk of dyslipidemia and coronary artery disease (CAD), limited data are available on their association with heart failure (HF).
  
  
  OBJECTIVE
  Our goal was to assess associations of plasma and dietary TFAs with HF and CAD.
  
  
  METHODS
  We used a prospective, nested case-control design to select 788 incident HF cases and 788 matched controls from the Physicians' Health Study for biomarker analyses and a prospective cohort for the dietary analyses. Plasma fatty acids were assessed by using gas chromatography, and dietary intake was estimated by using a food-frequency questionnaire. Self-reported HF was ascertained by using annual follow-up questionnaires with validation in a subsample. We used conditional logistic (or Cox) regression to estimate multivariable-adjusted ORs (or HRs) for HF and CAD.
  
  
  RESULTS
  Multivariable-adjusted ORs (95% CIs) for HF across consecutive quintiles of plasma trans 18:2 (linoleic acid) fatty acids were 1.0 (reference), 1.10 (0.79, 1.54), 0.88 (0.62, 1.25), 0.71 (0.49, 1.02), and 0.67 (0.45, 0.98) (P-trend = 0.01). Each SD of plasma trans 18:2 was associated with a 22% lower risk of HF (95% CI: 6%, 36%). Plasma trans 16:1 and 18:1 were not associated with risk of HF (P > 0.05). Dietary trans fats were not associated with incident HF or CAD.
  
  
  CONCLUSIONS
  Our data are consistent with a lower risk of HF with higher concentrations of plasma trans 18:2 but not with trans 16:1 or trans 18:1 fatty acids in male physicians. Dietary TFAs were not related to incident HF or CAD.
authors: Divisions of Aging and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
authors: Oluwabunmi A
authors: OA
authors: Tokede
authors: Andrew B
authors: AB
authors: Petrone
authors: Naomi Q
authors: NQ
authors: Hanson
authors: Michael Y
authors: MY
authors: Tsai
authors: Natalie A
authors: NA
authors: Weir
authors: Robert J
authors: RJ
authors: Glynn
authors: J Michael
authors: JM
authors: Gaziano
authors: Luc
authors: L
authors: Djoussé
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology*; D004311:Double-Blind Method; D006333:Heart Failure / Q000097:blood / Q000209:etiology*; D006801:Humans; D019787:Linoleic Acid / Q000097:blood / Q000494:pharmacology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010743:Phospholipids / Q000097:blood*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D057566:Self Report; D011795:Surveys and Questionnaires; D044242:Trans Fatty Acids / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*
chemical_list: D010743:Phospholipids; D044242:Trans Fatty Acids; D019787:Linoleic Acid