title: SOX2 overexpression correlates with poor prognosis in laryngeal squamous cell carcinoma.
abstract: OBJECTIVE
  The aim of present study was to investigate the expression of SOX2, a key transcription factor, in LSCC and to assess its prognostic significance.
  
  
  METHODS
  SOX2 expression of 161 LSCC tissues was detected by immunohistochemistry using a tissue microarray and statistically analyzed for its correlation with clinicopathological charateristics and patient outcome. In addition, SOX2 expression was also observed in 20 self-paired fresh LSCC tissues by western blot.
  
  
  RESULTS
  SOX2 was overexpressed in LSCC tissues as compared to the corresponding adjacent normal tissues. SOX2 expression was significantly associated with tumour T classification (p<0.001), clinical stage (p<0.001), lymph node metastasis (p=0.007) and recurrence (p=0.001). Univariate analysis revealed that patients with high SOX2 expression were significantly related to overall survival (p<0.001). Multivariate survival analysis further demonstrated that SOX2 expression was an independent prognostic factor for LSCC patients.
  
  
  CONCLUSIONS
  SOX2 may contribute to the malignant progression of laryngeal squamous cell carcinoma (LSCC), and present as a useful prognostic marker and a potential therapeutic target for LSCC patients.
authors: Department of Otolaryngology, Head and Neck Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, PR China.
authors: Xia-bing
authors: XB
authors: Tang
authors: Xiao-hui
authors: XH
authors: Shen
authors: Lei
authors: L
authors: Li
authors: Yi-fen
authors: YF
authors: Zhang
authors: Guo-qian
authors: GQ
authors: Chen
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055748:SOXB1 Transcription Factors / Q000378:metabolism*; D046888:Tissue Array Analysis
chemical_list: D015415:Biomarkers; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors