title: Surgical versus low-dose progestin treatment for endometriosis-associated severe deep dyspareunia II: effect on sexual functioning, psychological status and health-related quality of life.
abstract: OBJECTIVE
  Does surgical and low-dose progestin treatment differentially affect endometriosis-associated severe deep dyspareunia in terms of sexual functioning, psychological status and health-related quality of life?
  
  
  CONCLUSIONS
  Surgery and progestin treatment achieved essentially similar benefits at 12-month follow-up, but with different temporal trends.
  
  
  BACKGROUND
  Conservative surgery and hormonal therapies have been used independently for endometriosis-associated deep dyspareunia with inconsistent results.
  
  
  METHODS
  Patient preference, parallel cohort study with 12-month follow-up. The effect of conservative surgery at laparoscopy versus treatment with a low dose of norethisterone acetate per os (2.5 mg/day) in women with persistent/recurrent severe deep dyspareunia after first-line surgery was compared.
  A total of 51 patients chose repeat surgery and 103 progestin treatment. Variations in sexual function, psychological well-being and quality of life were measured by means of the Female Sexual Function Index (FSFI), the Hospital Anxiety and Depression Scale (HADS) and the Endometriosis Health Profile-30 (EHP-30).
  
  
  RESULTS
  Four women in the surgery group and 21 women in the progestin group withdrew from the study for various reasons. Total FSFI scores, anxiety and depression scores and EHP-30 scores improved immediately after surgery, but worsened with time, whereas the effect during progestin use increased more gradually, but progressively, without overall significant between-group differences at 12-month follow-up. A tendency was observed towards a slightly better total FSFI score after surgery at the end of the study period.
  
  
  CONCLUSIONS
  Treatments were not randomly allocated, and distribution of participants as well as of dropouts between study arms was unbalanced. However, the possibility of choosing the treatment allowed assessment of the maximum potential effect size of the interventions.
  
  
  CONCLUSIONS
  Both surgery and medical treatment with progestins are valuable options for improving the detrimental impact of endometriosis-associated dyspareunia on sexual functioning and quality of life. Women should be aware of the pros and cons of both options to decide which one best suits their needs.
  
  
  BACKGROUND
  This study was supported by a research grant from the University of Milan School of Medicine (PUR number 2009-ATE-0570). None of the authors have a conflict of interest.
authors: Clinica Ostetrica e GinecologicaI, Istituto 'Luigi Mangiagalli', Università Statale di Milano, Via Commenda 12, 20122 Milan, Italy. paolo.vercellini@unimi.it
authors: P
authors: P
authors: Vercellini
authors: M P
authors: MP
authors: Frattaruolo
authors: E
authors: E
authors: Somigliana
authors: G L
authors: GL
authors: Jones
authors: D
authors: D
authors: Consonni
authors: D
authors: D
authors: Alberico
authors: L
authors: L
authors: Fedele
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D003863:Depression / Q000150:complications; D004414:Dyspareunia / Q000188:drug therapy* / Q000523:psychology / Q000601:surgery*; D004715:Endometriosis / Q000188:drug therapy* / Q000523:psychology / Q000601:surgery*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D009640:Norethindrone / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077563:Norethindrone Acetate; D057240:Patient Preference; D011372:Progestins / Q000627:therapeutic use*; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D011372:Progestins; D000077563:Norethindrone Acetate; D009640:Norethindrone