title: The C-terminal extended serine residue is absolutely required in nosiheptide maturation.
abstract: Serine qua non: Substitution of the extended Ser13 in the core peptide of nosiheptide by analogous amino acids prevented enamide dealkylation of the terminal residue for nosiheptide maturation.
authors: State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009, PRC.
authors: Weiying
authors: W
authors: Liu
authors: Min
authors: M
authors: Ma
authors: Yanjiu
authors: Y
authors: Xue
authors: Nan
authors: N
authors: Liu
authors: Shuzhen
authors: S
authors: Wang
authors: Yijun
authors: Y
authors: Chen
mesh_terms: D000577:Amides / Q000737:chemistry; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D012694:Serine / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry / Q000378:metabolism
chemical_list: D000577:Amides; D000596:Amino Acids; D013844:Thiazoles; D012694:Serine; C014134:nosiheptide