title: Total syntheses of ainsliadimer B and gochnatiolides a and B.
abstract: Oh my goch: The total syntheses of ainsliadimer B and gochnatiolides A and B from α-santonin have been accomplished in 25 steps with approximately 1 % overall yield. A Diels-Alder reaction of natural dehydrozaluzanin C with a monomeric guaianolide derivative allows stereoselective assembly of a dimeric gochnatiolide-type skeleton with the required stereochemistry and preinstalled functionalities for the synthesis of dimeric ainsliadimer B and gochnatiolides A and B (see scheme).
authors: Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610041, PR China.
authors: Dongliang
authors: D
authors: Xia
authors: Yu
authors: Y
authors: Du
authors: Zhi
authors: Z
authors: Yi
authors: Hao
authors: H
authors: Song
authors: Yong
authors: Y
authors: Qin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry; D061565:Cycloaddition Reaction; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C584492:ainsliadimer B; C414948:dehydrozaluzanin C; C584491:gochnatiolide A; C584490:gochnatiolide B