title: Unique microstructural design of ceramic scaffolds for bone regeneration under load.
abstract: During the past two decades, research on ceramic scaffolds for bone regeneration has progressed rapidly; however, currently available porous scaffolds remain unsuitable for load-bearing applications. The key to success is to apply microstructural design strategies to develop ceramic scaffolds with mechanical properties approaching those of bone. Here we report on the development of a unique microstructurally designed ceramic scaffold, strontium-hardystonite-gahnite (Sr-HT-gahnite), with 85% porosity, 500μm pore size, a competitive compressive strength of 4.1±0.3MPa and a compressive modulus of 170±20MPa. The in vitro biocompatibility of the scaffolds was studied using primary human bone-derived cells. The ability of Sr-HT-gahnite scaffolds to repair critical-sized bone defects was also investigated in a rabbit radius under normal load, with β-tricalcium phosphate/hydroxyapatite scaffolds used in the control group. Studies with primary human osteoblast cultures confirmed the bioactivity of these scaffolds, and regeneration of rabbit radial critical defects demonstrated that this material induces new bone defect bridging, with clear evidence of regeneration of original radial architecture and bone marrow environment.
authors: Biomaterials and Tissue Engineering Research Unit, School of AMME, The University of Sydney, Sydney 2006, Australia.
authors: S I
authors: SI
authors: Roohani-Esfahani
authors: C R
authors: CR
authors: Dunstan
authors: J J
authors: JJ
authors: Li
authors: Zufu
authors: Z
authors: Lu
authors: B
authors: B
authors: Davies
authors: S
authors: S
authors: Pearce
authors: J
authors: J
authors: Field
authors: R
authors: R
authors: Williams
authors: H
authors: H
authors: Zreiqat
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000138:chemical synthesis*; D002516:Ceramics / Q000737:chemistry*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D017102:Fracture Healing / Q000502:physiology; D048091:Guided Tissue Regeneration / Q000295:instrumentation* / Q000379:methods; D008297:Male; D008422:Materials Testing; D011817:Rabbits; D011885:Radius Fractures / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D054457:Tissue Scaffolds; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes