title: Seizures induced by desloratadine, a second-generation antihistamine: clinical observations.
abstract: Some clinical experiences indicate that H1-antihistamines, especially first-generation H1-antagonists, occasionally provoke convulsions in healthy children as well as epileptic patients. Desloratadine is a frequently used second-generation antihistamine considered to be effective and safe for the treatment of allergic diseases. We describe four children who experienced epilepsy associated with the nonsedating H(1)-antagonist desloratadine and discuss the neurophysiologic role of the central histaminergic system in seizure susceptibility. In conclusion, we recommend caution in treating epileptic patients with the histamine H(1)-antagonists, including second- and third-generation drugs that are frequently referred because they are considered to be nonsedating antihistamines.
authors: Department of Neuroscience, Pediatric Neurology Unit, Tor Vergata University of Rome, Rome, Italy. caterinacerminara@hotmail.com
authors: Caterina
authors: C
authors: Cerminara
authors: Nadia
authors: N
authors: El-Malhany
authors: Denis
authors: D
authors: Roberto
authors: Adriana
authors: A
authors: Lo Castro
authors: Paolo
authors: P
authors: Curatolo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000139:chemically induced*; D005260:Female; D039563:Histamine H1 Antagonists, Non-Sedating / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D017336:Loratadine / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male
chemical_list: D039563:Histamine H1 Antagonists, Non-Sedating; D017336:Loratadine; C121345:desloratadine