title: SPG11 Presenting with Tremor.
abstract: BACKGROUND
  Hereditary spastic paraplegias (HSPs) are a clinically and genetically heterogeneous group of neurological diseases, which typically present with progressive lower extremity weakness and spasticity causing progressive walking difficulties. Complicating neurological or extraneurological features may be present.
  
  
  METHODS
  We describe a 19-year-old male who was referred because of an action tremor of the hands; he later developed walking difficulties. Callosal atrophy was present on his cerebral magnetic resonance imaging scan, prompting genetic testing for SPG11, which revealed homozygous mutations.
  
  
  CONCLUSIONS
  The clinical features, differential diagnosis and management of SPG11, the most common form of autosomal recessive complicated HSP with a thin corpus callosum are discussed.
authors: Schilling Section of Clinical and Molecular Neurogenetics, Department of Neurology, University Luebeck, Germany ; Dementia Research Centre, Institute of Neurology, London, United Kingdom.
authors: Susanne A
authors: SA
authors: Schneider
authors: Catherine J
authors: CJ
authors: Mummery
authors: Mohadeseh
authors: M
authors: Mehrabian
authors: Henry
authors: H
authors: Houlden
authors: Peter G
authors: PG
authors: Bain
keywords: SPG11; Tremor; hereditary spastic paraplegia; spatacsin