title: Why critically ill patients are protein deprived.
abstract: Critical illness dramatically increases muscle proteolysis and more than doubles the dietary protein requirement. Yet surprisingly, most critically ill patients receive less than half the recommended amount of protein during their stay in a modern intensive care unit. What could explain the wide gap between the recommendations in clinical care guidelines and actual clinical practice? We suggest that an important aspect of the problem is the failure of guidelines to explain the pathophysiology of protein-energy malnutrition and the ways critical illness modifies protein metabolism. The difficulty created by the lack of a framework for reasoning about appropriate protein provision in critical illness is compounded by the many ambiguous and often contradictory ways the word malnutrition is used in the critical care literature. Failing to elucidate these matters, the recommendations for protein provision in the guidelines are incoherent, unconvincing, and easy to ignore.
authors: Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. l.hoffer@mcgill.ca
authors: L John
authors: LJ
authors: Hoffer
authors: Bruce R
authors: BR
authors: Bistrian
mesh_terms: D000328:Adult; D016638:Critical Illness; D004044:Dietary Proteins / Q000008:administration & dosage*; D002149:Energy Intake; D019317:Evidence-Based Medicine; D006801:Humans; D007362:Intensive Care Units; D009747:Nutritional Physiological Phenomena; D009751:Nutritional Requirements; D017410:Practice Guidelines as Topic; D011502:Protein-Energy Malnutrition / Q000503:physiopathology*
chemical_list: D004044:Dietary Proteins