title: Prognostic significance of Ki-67 expression in rectal carcinoid tumors.
abstract: OBJECTIVE
  Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors.
  
  
  METHODS
  We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis.
  
  
  RESULTS
  The mean age (±SD) of the patients was 56.3±10.7 years, and the male : female ratio was 3.6 : 1. The mean tumor size was 0.5±0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7±1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4±25.4 months, and no recurrences were observed.
  
  
  CONCLUSIONS
  In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.
authors: Department of Internal Medicine, Inje University College of Medicine, Seoul, Korea.
authors: Su Min
authors: SM
authors: Hong
authors: You Sun
authors: YS
authors: Kim
authors: Jung Seop
authors: JS
authors: Moon
authors: Jin Nam
authors: JN
authors: Kim
authors: Myoung Ki
authors: MK
authors: Oh
authors: Sun Ok
authors: SO
authors: Kwon
authors: Seong Yeon
authors: SY
authors: Jeong
authors: Seong Woo
authors: SW
authors: Hong
authors: Yun Kyung
authors: YK
authors: Kang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D019394:Ki-67 Antigen