title: Safety evaluation of excessive ingestion of mozuku fucoidan in human.
abstract: Fucoidan is a sulfated polysaccharide in the brown sea algae. This study was conducted in 20 subjects taking excessive fucoidan up to 4.05 g daily for 2 wk. They recorded questionnaire sheets about their health. Blood and urine were collected before and after 2 wk of ingestion. We found that no disorder was apparent in the test period. Although total cholesterol (P value 0.017) and low-density lipoprotein cholesterol (P value 0.017) showed statistically significant reduction and Cl (P value 0.002) showed significant increase, nothing deviated from the range of normal values. In conclusion, this study showed no abnormalities in the abdominal, fecal states, blood and urine at all.
authors: Marine Products Kimuraya Co., Ltd., Sakaiminato, Tottori 684-0072, Japan. abe@mozuku1-ban.jp
authors: Sunao
authors: S
authors: Abe
authors: Kimiko
authors: K
authors: Hiramatsu
authors: Osamu
authors: O
authors: Ichikawa
authors: Hitoshi
authors: H
authors: Kawamoto
authors: Takeshi
authors: T
authors: Kasagi
authors: Yasunari
authors: Y
authors: Miki
authors: Takayuki
authors: T
authors: Kimura
authors: Tadasu
authors: T
authors: Ikeda
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003257:Consumer Product Safety; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D000459:Phaeophyceae / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage* / Q000097:blood / Q000633:toxicity* / Q000652:urine; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D011134:Polysaccharides; D014280:Triglycerides; C007789:fucoidan