title: Prognostic relevance of PCI-related myocardial infarction.
abstract: Procedure-related myocardial infarction (pMI) is directly associated with a coronary revascularization procedure, such as percutaneous coronary intervention (PCI) or CABG surgery. In contrast to spontaneous myocardial infarction (MI), the prognostic relevance of pMI is the subject of ongoing debate. Data from retrospective analyses of large, randomized clinical trials, and large, contemporary cohort studies have several shortcomings that limit their extrapolation to clinical practice. In our opinion, the currently available evidence is insufficient to conclude that pMI during PCI, as currently defined, always has important prognostic implications. Until further evidence is available, we recommend adopting the definition for MI given in the third universal definition of MI, which differentiates between pMI and spontaneous MI. This is important not only for clinical decision-making but also for the interpretation of pMI as a surrogate end point in clinical trials. Further studies are essential to understand the pathophysiology and consequences of pMI.
authors: Department of Cardiology, Room B2-137, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors: Pier
authors: P
authors: Woudstra
authors: Maik J
authors: MJ
authors: Grundeken
authors: Tim P
authors: TP
authors: van de Hoef
authors: Lars
authors: L
authors: Wallentin
authors: Keith A
authors: KA
authors: Fox
authors: Robbert J
authors: RJ
authors: de Winter
authors: Peter
authors: P
authors: Damman
mesh_terms: D015415:Biomarkers / Q000097:blood; D019317:Evidence-Based Medicine; D006801:Humans; D015201:Meta-Analysis as Topic; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000401:mortality; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers