title: Evaluation of the effects of ozone therapy on Escherichia coli-induced cytitis in rat.
abstract: OBJECTIVE
  The aim of the study was to investigate the effect of ozone on oxidative/nitrosative stress and bladder injury caused by Escherichia coli in rat bladder.
  
  
  METHODS
  Twenty-one Wistar-Albino-type female rats included in the study were divided into three groups of equal number: (1) sham operation (control), (2) E. coli-only (EC), (3) EC + ozone. After ozone therapy for 3 days, urine and tissue samples were obtained for biochemical, microbiological, and histopathological analysis.
  
  
  RESULTS
  Tissue malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) level were increased, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity was decreased in the EC group. MDA, MPO, and NO levels were decreased, whereas SOD, GPx activity was increased in the ozone-treated group. Also, there was no bacterial translocation in this group.
  
  
  CONCLUSIONS
  The results of the present study suggest that ozone may be used as an agent to protect the bladder from oxidative/nitrosative stress occurring in cystitis.
authors: Department of Urology, School of Medicine, Inonu University, Malatya, Turkey, tasdemrcemal@yahoo.com.
authors: C
authors: C
authors: Tasdemir
authors: S
authors: S
authors: Tasdemir
authors: N
authors: N
authors: Vardi
authors: B
authors: B
authors: Ates
authors: Y
authors: Y
authors: Onal
authors: S
authors: S
authors: Erdogan
authors: A
authors: A
authors: Yucel
authors: E
authors: E
authors: Aglamis
authors: Y
authors: Y
authors: Yakupogullari
authors: R
authors: R
authors: Altıntas
authors: A
authors: A
authors: Karaman
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018988:Bacterial Translocation / Q000187:drug effects; D003556:Cystitis / Q000188:drug therapy* / Q000382:microbiology; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010126:Ozone / Q000494:pharmacology*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D001743:Urinary Bladder / Q000187:drug effects* / Q000382:microbiology; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D009569:Nitric Oxide; D008315:Malondialdehyde; D010126:Ozone; D009195:Peroxidase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase