title: Opening up the window into "chemobrain": a neuroimaging review.
abstract: As more chemotherapy-treated cancer patients are reaching survivorship, side-effects such as cognitive impairment warrant research attention. The advent of neuroimaging has helped uncover a neural basis for these deficits. This paper offers a review of neuroimaging investigations in chemotherapy-treated adult cancer patients, discussing the benefits and limitations of each technique and study design. Additionally, despite the assumption given by the chemobrain label that chemotherapy is the only causative agent of these deficits, other factors will be considered. Suggestions are made on how to more comprehensively study these cognitive changes using imaging techniques, thereby promoting generalizability of the results to clinical applications. Continued investigations may yield better long-term quality of life outcomes by supporting patients' self-reports, and revealing brain regions being affected by chemotherapy.
authors: Memory and Aging Center, Neurology, UCSF, Sandler Neuroscience Center, 675 Nelson Rising Lane, San Francisco, CA 94158, USA. cscherling@memory.ucsf.edu
authors: Carole S
authors: CS
authors: Scherling
authors: Andra
authors: A
authors: Smith
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D003072:Cognition Disorders / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009369:Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D059906:Neuroimaging / Q000379:methods; D011788:Quality of Life; D011859:Radiography