title: Newborn body fat: associations with maternal metabolic state and placental size.
abstract: BACKGROUND
  Neonatal body composition has implications for the health of the newborn both in short and long term perspective. The objective of the current study was first to explore the association between maternal BMI and metabolic parameters associated with BMI and neonatal percentage body fat and to determine to which extent any associations were modified if adjusting for placental weight. Secondly, we examined the relations between maternal metabolic parameters associated with BMI and placental weight.
  
  
  METHODS
  The present work was performed in a subcohort (n = 207) of the STORK study, an observational, prospective study on the determinants of fetal growth and birthweight in healthy pregnancies at Oslo University Hospital, Norway. Fasting glucose, insulin, triglycerides, free fatty acids, HDL- and total cholesterol were measured at week 30-32. Newborn body composition was determined by Dual-Energy X-Ray Absorptiometry (DXA). Placenta was weighed at birth. Linear regression models were used with newborn fat percentage and placental weight as main outcomes.
  
  
  RESULTS
  Maternal BMI, fasting glucose and gestational age were independently associated with neonatal fat percentage. However, if placental weight was introduced as a covariate, only placental weight and gestational age remained significant. In the univariate model, the determinants of placenta weight included BMI, insulin, triglycerides, total- and HDL-cholesterol (negatively), gestational weight gain and parity. In the multivariable model, BMI, total cholesterol HDL-cholesterol, gestational weight gain and parity remained independent covariates.
  
  
  CONCLUSIONS
  Maternal BMI and fasting glucose were independently associated with newborn percentage fat. This effect disappeared by introducing placental weight as a covariate. Several metabolic factors associated with maternal BMI were associated with placental weight, but not with neonatal body fat. Our findings are consistent with a concept that the effects of maternal BMI and a number of BMI-related metabolic factors on fetal fat accretion to a significant extent act by modifying placental weight.
authors: Section for Obstetrics, Women and Children's Division, Rikshospitalet, Oslo University Hospital, Oslo, Norway. camilla.friis@ous-hf.no
authors: Camilla M
authors: CM
authors: Friis
authors: Elisabeth
authors: E
authors: Qvigstad
authors: Marie Cecilie
authors: MC
authors: Paasche Roland
authors: Kristin
authors: K
authors: Godang
authors: Nanna
authors: N
authors: Voldner
authors: Jens
authors: J
authors: Bollerslev
authors: Tore
authors: T
authors: Henriksen
mesh_terms: D000273:Adipose Tissue / Q000502:physiology*; D000328:Adult; D001724:Birth Weight / Q000502:physiology; D015992:Body Mass Index; D003710:Demography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008660:Metabolism; D009035:Mothers; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology*; D011247:Pregnancy