title: F-18 FDG-PET/CT in evaluation of patients with fever of unknown origin.
abstract: OBJECTIVE
  This study was carried out to evaluate the diagnostic utility of FDG-PET/CT in patients with fever of unknown origin (FUO).
  
  
  METHODS
  Medical records of 103 patients who underwent FDG-PET/CT and anatomic imaging as a part of FUO workup were analyzed. Final diagnosis of the cause of FUO was reached based on serologic assays, cultures, biopsy, surgery or 6 months of clinical follow-up.
  
  
  RESULTS
  The definite cause of fever was established in 69/103 patients. Abnormal FDG uptake was found in 63/103 patients and contributed to the final diagnosis (TP) in 62 patients (98.48 %). Of the remaining 40 patients with negative PET/CT, the final definite cause of fever (FN) could be determined only in seven patients (17.5 %). PET/CT had a sensitivity, specificity, positive predictive value and negative predictive value of 90, 97, 98.4 and 82.5 % compared to 43.5, 67.6, 73.2 and 37.1 %, respectively, for anatomic imaging. FDG-PET/CT had a higher accuracy (92.2 vs. 51.5 %; p = 0.003) compared to anatomic imaging for suggesting a cause of FUO.
  
  
  CONCLUSIONS
  PET/CT showed high sensitivity and specificity in suggesting a definite diagnosis in the evaluation of FUO.
authors: Department of Nuclear Medicine & PET, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
authors: Kuruva
authors: K
authors: Manohar
authors: Bhagwant Rai
authors: BR
authors: Mittal
authors: Sanjay
authors: S
authors: Jain
authors: Aman
authors: A
authors: Sharma
authors: Naveen
authors: N
authors: Kalra
authors: Anish
authors: A
authors: Bhattacharya
authors: Subhash
authors: S
authors: Varma
mesh_terms: D000368:Aged; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019788:Fluorodeoxyglucose F18