title: The volumetric relationship of white matter lesion and contrast-enhanced lesion in delayed radiation brain injury: an MRI-based study.
abstract: OBJECTIVE
  This study investigated the volumetric relationship of white matter lesion (WML) and contrast-enhanced lesion (CEL) in delayed radiation brain injury (RBI) during the course of evolution.
  
  
  METHODS
  MRI results in 45 patients with RBI after receiving radiation for nasopharyngeal carcinoma were analyzed. In total there were 75 lobes with RBI and 114 MRI examinations in this study. WML and CEL lesion volumes were measured. The lesion volume change of less than 5% or 0.25 cm(3) was regarded as being static.
  
  
  RESULTS
  The average WML volume was 16.33 cm(3) (ranging 0.11 cm(3) to 102.83 cm(3)), and the average CEL volume was 3.15 cm(3) (ranging 0.03 cm(3) to 27.85 cm(3)). WML was larger than CEL in 164 measurements, and CEL was larger than WML in 10 measurements. In 64.3% follow-ups WML and CEL evolved in the same pattern; and in most follow-ups (93.8%) WML and CEL did not evolve in the opposite directions. A larger WML volume tended to have a larger CEL volume though this relationship was not linear.
  
  
  CONCLUSIONS
  Evolution of WML and CEL tended to follow the same pattern. WML tended to be larger than CEL, and larger WML tended to be associated with larger CEL.
authors: Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P. R. China. yixiang_wang@cuhk.edu.hk
authors: Y X J
authors: YX
authors: Wang
authors: H
authors: H
authors: Huang
authors: S F
authors: SF
authors: Leung
authors: D K W
authors: DK
authors: Yeung
authors: Y L
authors: YL
authors: Chan
authors: W S
authors: WS
authors: Poon
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000528:radiation effects*; D003287:Contrast Media; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media