title: Using susceptibility-weighted images to quantify iron deposition differences in amnestic mild cognitive impairment and Alzheimer's disease.
abstract: OBJECTIVE
  To quantify iron deposition in Alzheimer's disease (AD), amnestic mild cognitive impairment (aMCI), and control individuals using susceptibility weighted imaging (SWI).
  
  
  METHODS
  Sixty participants (22 aMCI, 20 AD, 18 normal controls) underwent conventional magnetic resonance imaging (MRI) and SWI using axial/oblique coronal sequences. Phase images were used to calculate bilateral iron deposition in 18 regions of interest (ROI). The radian angle value was calculated and compared between the three participant groups.
  
  
  RESULTS
  The difference in radian angle value was significant between the aMCI and control groups in the left (L)-hippocampus, L-head of the caudate nucleus, R-lenticular nucleus, L-lenticular nucleus (P =0.02239, <0. 001, 0.03571, 0.00943, respectively). The difference in radian angle value was significant between the AD and aMCI groups in the R-cerebellar hemisphere, L-cerebellar hemisphere, R-hippocampus, L-hippocampus, R-red nucleus, R-thalamus, L-thalamus, and splenium of corpus callosum (P =0.02754, 0.01839, 0.00934, 0.04316, 0.02472, 0.00152, <0.001, 0.01448, respectively). Pearson correlation coefficients of the Mini-Mental State Examination score were all significant for the bilateral cerebellar hemisphere, hippocampus, red nucleus, lenticular nucleus, thalamus, R-head of the caudate nucleus, and splenium of corpus callosum.
  
  
  CONCLUSIONS
  Iron deposition in the hippocampus, head of the caudate nucleuslenticular nucleus, and thalamus are significantly different between individuals with aMCI, AD, and controls. The thalamus is a particularly sensitive area. Using SWI to quantify the iron deposition is a useful tool in detecting aMCI and AD.
authors: Department of Diagnostic and Interventional Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors: Dan
authors: D
authors: Wang
authors: Dan
authors: D
authors: Zhu
authors: Xiao-Er
authors: XE
authors: Wei
authors: Yue-Hua
authors: YH
authors: Li
authors: Wen-Bin
authors: WB
authors: Li
mesh_terms: D000544:Alzheimer Disease; D060825:Cognitive Dysfunction; D006624:Hippocampus; D006801:Humans; D007501:Iron; D008279:Magnetic Resonance Imaging
chemical_list: D007501:Iron