title: Pre-existing immunity to norovirus GII-4 virus-like particles does not impair de novo immune responses to norovirus GII-12 genotype.
abstract: Noroviruses (NoVs) are one of the leading causes of acute nonbacterial gastroenteritis in humans of all ages. In the 1990s, NoV genotype GII-4 became responsible for the majority of NoV sporadic gastroenteritis cases and outbreaks worldwide. Vaccine development against NoV GII-4 is underway. At the same time, there is concern of new emerging NoV genotypes, such as GII-12, which has been recently associated with increasing numbers of NoV outbreaks worldwide. The specific question is whether type-specific pre-existing immunity to NoV GII-4 might impair cognate immune response induced by new viral infections or vaccines. Using GII-4 and GII-12 virus-like particles, we tested the impact of the immunity generated against NoV GII-4 on de novo antibody responses to GII-12 in mice. We found that pre-existing immunity to NoV GII-4 did not impair de novo immune response to the novel antigen, therefore suggesting lack of original antigenic sin (OAS).
authors: Vaccine Research Center, University of Tampere Medical School, Tampere, Finland.
authors: Kirsi
authors: K
authors: Tamminen
authors: Leena
authors: L
authors: Huhti
authors: Timo
authors: T
authors: Vesikari
authors: Vesna
authors: V
authors: Blazevic
mesh_terms: D000818:Animals; D017250:Caliciviridae Infections / Q000276:immunology* / Q000821:virology*; D003429:Cross Reactions; D005260:Female; D005838:Genotype; D007108:Immune Tolerance; D051379:Mice; D008807:Mice, Inbred BALB C; D029322:Norovirus / Q000145:classification / Q000235:genetics / Q000276:immunology*; D058425:Vaccines, Virus-Like Particle / Q000008:administration & dosage / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D058425:Vaccines, Virus-Like Particle; D014765:Viral Vaccines