title: Regulation of CRAC channels by protein interactions and post-translational modification.
abstract: Store-operated Ca(2+) entry (SOCE) is a widespread mechanism to elevate the intracellular Ca(2+) concentrations and stimulate downstream signaling pathways affecting proliferation, secretion, differentiation and death in different cell types. In immune cells, immune receptor stimulation induces intracellular Ca(2+) store depletion that subsequently activates Ca(2+)-release-activated-Ca(2+) (CRAC) channels, a prototype of store-operated Ca(2+) (SOC) channels. CRAC channel opening leads to activation of diverse downstream signaling pathways affecting proliferation, differentiation, cytokine production and cell death. Recent identification of STIM1 as the endoplasmic reticulum Ca(2+) sensor and Orai1 as the pore subunit of CRAC channels has provided the much-needed molecular tools to dissect the mechanism of activation and regulation of CRAC channels. In this review, we discuss the recent advances in understanding the associating partners and posttranslational modifications of Orai1 and STIM1 proteins that regulate diverse aspects of CRAC channel function.
authors: Department of Physiology; David Geffen School of Medicine at UCLA; Los Angeles, CA USA.
authors: Sonal
authors: S
authors: Srikanth
authors: Department of Physiology; David Geffen School of Medicine at UCLA; Los Angeles, CA USA.
authors: Bernard
authors: B
authors: Ribalet
authors: Department of Physiology; David Geffen School of Medicine at UCLA; Los Angeles, CA USA.
authors: Yousang
authors: Y
authors: Gwack
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D008565:Membrane Proteins / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D000071740:ORAI1 Protein; D011499:Protein Processing, Post-Translational; D000071737:Stromal Interaction Molecule 1
chemical_list: D015220:Calcium Channels; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C103530:STIM1 protein, human; D000071737:Stromal Interaction Molecule 1
keywords: Ca2+-release-activated-Ca2+ channels; Orai1; STIM1; endoplasmic reticulum; plasma membrane junctions; store-operated Ca2+ entry