title: Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?
abstract: OBJECTIVE
  Plasma levels of some biomarkers and markers of collagen turnover may reflect myocardial structural abnormalities associated with diastolic dysfunction. The aim of this study was to determine whether these markers could contribute to the diagnostics of heart failure with normal ejection fraction (HFNEF).
  
  
  RESULTS
  91 patients with exertional dyspnea and normal left ventricular ejection fraction and 20 healthy controls underwent plasma analysis of markers of collagen turnover and other biomarkers, spirometry, and resting and exercise echocardiography. 38 patients with dyspnea had evidence of HFNEF, diagnosed at the early stage. Compared to the remaining patients, those with HFNEF had a significantly higher plasma levels of carboxy-terminal telopeptide of collagen type I (median 4.5 µg/L vs. 3.5 µg/L, P<0.05) and big endothelin (median 1.1 pmol/L vs 0.9 pmol/L, P<0.05). Univariate logistic regression analysis revealed a significant association between HFNEF and the following biomarkers: big endothelin, amino-terminal propeptide of type III procollagen (PIIINP), and matrix metalloproteinase-2 (MMP-2). However, none of these biomarkers independently contributed to the HFNEF diagnostics in a multivariate logistic regression analysis.
  
  
  CONCLUSIONS
  Plasma levels of big endothelin, PIIINP, and MMP-2 were found to be associated with the presence of early diagnosed HFNEF. However, none of these biomarkers contributed independently to current noninvasive HFNEF diagnostics recommended by the European Society of Cardiology guidelines.
authors: 1st Department of Internal Medicine-Cardioangiology, ICRC, St. Anne's University Hospital in Brno and Masaryk University, Brno, Czech Republic.
authors: Jaroslav
authors: J
authors: Meluzin
authors: Josef
authors: J
authors: Tomandl
authors: Helena
authors: H
authors: Podrouzkova
authors: Zdenka
authors: Z
authors: Gregorova
authors: Vladimir
authors: V
authors: Soska
authors: Petr
authors: P
authors: Dobsak
authors: Ladislav
authors: L
authors: Pecen
authors: Radka
authors: R
authors: Stepanova
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume
chemical_list: D015415:Biomarkers; D003094:Collagen