title: Sclerosing angiomatoid nodular transformation of the spleen related to IgG4-associated disease: report of a case.
abstract: Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare benign vascular mass, with fewer than 100 cases documented. It is generally recognized as a vascular lesion that develops in the red pulp of the spleen; however, its pathogenesis is not clearly defined. We report a case of SANT of the spleen, which presents evidence to support the hypothesis that this disease entity is associated with IgG4-associated disease. Microscopically, the tumor was composed of multiple vascular structures separated by fibrous connective tissue and immunohistochemical examination revealed positive staining for CD31, CD34, factor VIII, and IgG4. Further research based on large number of cases is warranted to clarify the pathogenesis of this tumor.
authors: Department of Surgery, Chonnam National University Medical School, 322, Seoyang-ro, Hwasun-eup, Hwasun-gun, Gwangju, Jeollanam-do, 519-763, Korea. gskhh@naver.com
authors: Ho-Hyun
authors: HH
authors: Kim
authors: Young-Hoe
authors: YH
authors: Hur
authors: Yang-Seok
authors: YS
authors: Koh
authors: Jung-Chul
authors: JC
authors: Kim
authors: Hyun-Jong
authors: HJ
authors: Kim
authors: Jin-Woong
authors: JW
authors: Kim
authors: Young
authors: Y
authors: Kim
authors: Jae-Hyuk
authors: JH
authors: Lee
authors: Chol-Kyoon
authors: CK
authors: Cho
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D003952:Diagnostic Imaging; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000098:blood supply / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007120:Immunochemistry; D007074:Immunoglobulin G / Q000378:metabolism*; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D013154:Spleen / Q000276:immunology* / Q000473:pathology*; D013160:Splenic Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology*
chemical_list: D018952:Antigens, CD34; D007074:Immunoglobulin G; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D005169:Factor VIII