title: Percutaneous pulmonary artery denervation completely abolishes experimental pulmonary arterial hypertension in vivo.
abstract: OBJECTIVE
  The study sought to assess the effect of percutaneous pulmonary artery denervation (PADN) on balloon-occlusion-induced acute pulmonary arterial hypertension (PAH) in vivo. The PADN is a minimally invasive and endovascular catheter-based interventional therapy using radiofrequency ablation to abolish the pulmonary arterial baroreceptors to pressure response.
  
  
  RESULTS
  To examine the efficacy of balloon-occlusion-induced PAH, twenty Mongolian dogs were randomly assigned to one of two groups: group 1 (left distal pulmonary basal trunk occlusion) and group 2 (left pulmonary interlobar artery occlusion). Afterwards, PADN treatment at the main pulmonary artery bifurcation level with left pulmonary interlobar artery occlusion in all 20 dogs was conducted. Haemodynamic parameters were measured at baseline and during balloon occlusion as well as the PADN treatment at different time points: one, two, three, five, and ten minutes. Before the PADN treatment, most haemodynamic parameters of the pulmonary artery remained unchanged in group 1 with distal pulmonary basal trunk occlusion. However, in group 2 with the occlusion of the left pulmonary interlobar artery, mean pulmonary arterial pressure, mean right ventricular pressure, and pulmonary vessel resistance gradually increased, and mean absolute difference reached peak at five minutes (Δ16.6 mmHg, Δ14.1 mmHg and Δ1,144 dye/s/cm5, respectively; each p<0.01). These haemodynamic parameters at five minutes induced by left pulmonary interlobar artery occlusion were completely abolished with the PADN treatment compared to baseline (Δ0.3 mmHg, Δ0.2 mmHg, and Δ34 dye/s/cm5, respectively).
  
  
  CONCLUSIONS
  Balloon occlusion of the left pulmonary interlobar artery led to a significant increase of haemodynamic parameters of the pulmonary artery. The pressure responses were completely abolished by the PADN treatment at the main bifurcation area of the left pulmonary artery.
authors: Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. chmengx126@gmail.com
authors: Shao-Liang
authors: SL
authors: Chen
authors: Yao-Jun
authors: YJ
authors: Zhang
authors: Lin
authors: L
authors: Zhou
authors: Du-Jiang
authors: DJ
authors: Xie
authors: Feng-Fu
authors: FF
authors: Zhang
authors: Hai-Bo
authors: HB
authors: Jia
authors: Sally S
authors: SS
authors: Wong
authors: Tak W
authors: TW
authors: Kwan
mesh_terms: D000818:Animals; D062186:Arterial Pressure; D017704:Baroreflex; D017115:Catheter Ablation; D004195:Disease Models, Animal; D004285:Dogs; D057510:Endovascular Procedures; D065627:Familial Primary Pulmonary Hypertension; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D040542:Mechanotransduction, Cellular; D011311:Pressoreceptors / Q000503:physiopathology / Q000601:surgery; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000294:innervation / Q000503:physiopathology / Q000601:surgery*; D011859:Radiography; D013562:Sympathectomy / Q000379:methods*; D013997:Time Factors