title: Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates.
abstract: OBJECTIVE
  To determine the effects of low-dose dopamine on urine output (UOP) in very low birth weight premature neonates.
  
  
  METHODS
  Retrospective cohort study of all low-dose (3-5 μg kg(-1) per min) dopamine infusions >24-h duration in neonates 1500 g and 32 weeks gestation from August 2009 through September 2011. Linear regression was used to estimate the impact of covariates on UOP.
  
  
  RESULTS
  We identified 91 episodes of low-dose dopamine use in 65 neonates. Increased UOP occurred in 64% of episodes. Low-dose dopamine use was associated with a 0.6 ml kg(-1) h(-1) increase in UOP (P<0.001) and a 1.3 ml kg(-1)h(-1) increase when baseline UOP was <1.5 ml kg(-1) h(-1) (P<0.001). The improvement remained statistically significant after controlling for medications (diuretics and hydrocortisone) and fluid intake.
  
  
  CONCLUSIONS
  Low-dose dopamine use was associated with increased UOP in very low birth weight neonates.
authors: Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
authors: J L
authors: JL
authors: Crouchley
authors: P B
authors: PB
authors: Smith
authors: C M
authors: CM
authors: Cotten
authors: C D
authors: CD
authors: Hornik
authors: R N
authors: RN
authors: Goldberg
authors: J W
authors: JW
authors: Foreman
authors: J L
authors: JL
authors: Wynn
mesh_terms: D004298:Dopamine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000502:physiology*; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D012189:Retrospective Studies; D014554:Urination / Q000187:drug effects*; D014556:Urine
chemical_list: D004298:Dopamine