title: Functional living biointerphases.
abstract: Lactococcus lactis is modified to express a fibronectin fragment (FNIII₇₋₁₀) as a membrane protein. This interphase, based on a living system, can be further exploited to provide spatio-temporal factors to direct cell function at the material interface. This approach establishes a new paradigm in biomaterial surface functionalization for biomedical applications.
authors: Abengoa Research, Abengoa, Campus Palmas Altas, Sevilla, Spain.
authors: Anas
authors: A
authors: Saadeddin
authors: Aleixandre
authors: A
authors: Rodrigo-Navarro
authors: Vicente
authors: V
authors: Monedero
authors: Patricia
authors: P
authors: Rico
authors: David
authors: D
authors: Moratal
authors: María Luisa
authors: ML
authors: González-Martín
authors: David
authors: D
authors: Navarro
authors: Andrés J
authors: AJ
authors: García
authors: Manuel
authors: M
authors: Salmerón-Sánchez
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D002470:Cell Survival; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D005353:Fibronectins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D013294:Lactococcus lactis / Q000378:metabolism*; D051379:Mice; D018613:Microscopy, Confocal; D011485:Protein Binding; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013499:Surface Properties
chemical_list: D005353:Fibronectins; D011993:Recombinant Fusion Proteins; D049452:Green Fluorescent Proteins; D051416:Focal Adhesion Protein-Tyrosine Kinases
keywords: bacteria; cell adhesion; fibronectin; integrin; interface