title: Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya.
abstract: The effect of the levonorgestrel-releasing intrauterine device (LNG-IUD) on genital HIV-1 RNA shedding and inflammation among 25 HIV-infected women was evaluated. Blood, endocervical, and cervicovaginal lavage samples were collected from HIV-infected women not taking antiretrovirals before LNG-IUD insertion and 1 month, 3 month, and 6 months thereafter. HIV-1 RNA was quantitated by real-time reverse transcriptase-polymerase chain reaction. Inflammatory markers were measured by enzyme immunoassay. Genital HIV-1 RNA shedding and inflammatory markers did not differ between LNG-IUD placement and month 6, with the exception of interleukin 1β that increased (0.42 log10; 95% confidence interval: 0.10 to 0.75). The LNG-IUD did not increase genital HIV-1 RNA shedding after 6 months of use.
authors: Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. colemanj@jhmi.edu
authors: Jenell S
authors: JS
authors: Coleman
authors: Christina
authors: C
authors: Mwachari
authors: Jennifer
authors: J
authors: Balkus
authors: Lucy
authors: L
authors: Sanguli
authors: Angela
authors: A
authors: Muliro
authors: Kathy
authors: K
authors: Agnew
authors: Robert W
authors: RW
authors: Coombs
authors: Craig R
authors: CR
authors: Cohen
authors: Jane
authors: J
authors: Hitti
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D002584:Cervix Uteri; D003271:Contraceptive Agents, Female / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D007436:Intrauterine Devices, Medicated; D007630:Kenya; D016912:Levonorgestrel / Q000627:therapeutic use*; D012367:RNA, Viral / Q000032:analysis* / Q000097:blood*; D044364:Vaginal Douching
chemical_list: D044966:Anti-Retroviral Agents; D003271:Contraceptive Agents, Female; D053583:Interleukin-1beta; D012367:RNA, Viral; D016912:Levonorgestrel