title: Management of cataracts and oculo-cutaneous malignancy in xeroderma pigmentosum.
abstract: This case report describes the management of a 17-year-old woman with xeroderma pigmentosum (XP) with bilateral mature cataract, conjunctival squamous cell carcinoma in the left eye (OS) and a cutaneous squamous cell carcinoma on her nose. To our knowledge, this is the first reported XP case with a cataract developing in the last couple of years without any ocular trauma, any history of inadequate diet or of previous corticosteroid use. We believe that cataracts can be related to improper working of the DNA repair mechanism of the lens epithelial cells in XP patients.
authors: Department of Ophthalmology, Ankara Training and Research Hospital, Ministry of Health, Ankara, Turkey.
authors: Dilek
authors: D
authors: Yuksel
authors: Mustafa
authors: M
authors: Kosker
authors: Jagadesh C
authors: JC
authors: Reddy
authors: Tuba
authors: T
authors: Celik
mesh_terms: D000293:Adolescent; D001684:Biological Dressings; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D002386:Cataract / Q000209:etiology / Q000628:therapy*; D003230:Conjunctival Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular; D016685:Mitomycin / Q000008:administration & dosage; D018918:Phacoemulsification; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D014792:Visual Acuity / Q000502:physiology; D014983:Xeroderma Pigmentosum / Q000150:complications*
chemical_list: D016685:Mitomycin