title: Poor sleep in PCOS; is melatonin the culprit?
abstract: OBJECTIVE
  Are daily cycles in urinary melatonin and oxidative stress marker levels (8-hydroxydeoxyguanosine) altered in PCOS, and is this associated with changes in sleep quality?
  
  
  CONCLUSIONS
  There is an association between elevated nighttime melatonin and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, and poor sleep quality in our PCOS study group.
  
  
  BACKGROUND
  Women with PCOS are known to have poorer sleep. However, there have been few studies examining the possible association between melatonin levels and sleep quality in women with polycystic ovarian syndrome (PCOS).
  
  
  METHODS
  This is a case-control study of PCOS (n = 26) and non-PCOS control (n = 26) subjects recruited from a tertiary gynaecological centre.
  
  
  METHODS
  The participants were requested to complete sleep questionnaires for a month. In a subgroup from these cohorts (PCOS, n = 15; controls, n = 18), urine samples were also collected at various time points over a 24-h period. In addition, their sleep patterns and lighting environment were monitored for 3 consecutive days and nights using a wrist-mounted Actiwatch device.
  
  
  RESULTS
  PCOS women had significantly elevated night-time urinary levels of the melatonin metabolite 6-sulfatoxymelatonin (aMT6s) and of 8-OHdG (both at P < 0.05), as well as significantly reduced sleep quality (P < 0.05), compared with the controls.
  
  
  CONCLUSIONS
  Due to the small sample size of the study, further studies will be required to confirm our findings.
  
  
  CONCLUSIONS
  Our preliminary work provides a possible new insight into the interactions between melatonin, increased oxidative stress and sleep in women with PCOS.
  
  
  BACKGROUND
  The study was funded by the Faculty of Medicine, University of Southampton.
authors: Princess Anne Hospital, University of Southampton, Level F, Southampton University Hospital NHS Trust, Southampton, Hampshire SO16 5YA, UK. ns605@soton.ac.uk
authors: N
authors: N
authors: Shreeve
authors: F
authors: F
authors: Cagampang
authors: K
authors: K
authors: Sadek
authors: M
authors: M
authors: Tolhurst
authors: A
authors: A
authors: Houldey
authors: C M
authors: CM
authors: Hill
authors: N
authors: N
authors: Brook
authors: N
authors: N
authors: Macklon
authors: Y
authors: Y
authors: Cheong
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008550:Melatonin / Q000378:metabolism* / Q000652:urine; D008991:Monitoring, Physiologic; D018384:Oxidative Stress; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000503:physiopathology*; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000150:complications* / Q000175:diagnosis*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D006728:Hormones; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D008550:Melatonin