title: Expression of osteopontin in patients with thyroid dysfunction.
abstract: Thyroid dysfunctions are common endocrine problems. They are often misdiagnosed, misunderstood, and frequently overlooked. These disorders affect almost every aspect of health. Most of them remain undetected because the clinical assessment alone lacks both sensitivity and specificity. As it is not sufficient enough we require the biochemical tests to confirm the diagnosis. As a consequence there is still great interest in new biomarkers that complement existing diagnostic tools. Osteopontin, a glycoprotein that can be detected in plasma, was found to be upregulated in several patients with hyperthyroidism and downregulated in hypothyroid patients so it may represent a new biomarker. 100 patients with thyroid dysfunctions (50 hyperthyroid, 50 hypothyroid) and 100 normal subjects were included in the study. Osteopontin and other clinical parameters for diagnosis of thyroid disorders were measured. Osteopontin is positively correlated with T3 and T4 (r = 0.62 and r = 0.75 respectively) while it is negatively correlated with thyroid stimulating hormone (r = -0.52) showing a significant correlation (p-value <0.001). Our findings suggest that osteopontin might be useful as a novel prognostic biomarker in patients with impaired thyroid function.
authors: Pathology Department, Quaid-e-Azam Medical College, Bahawalpur, Pakistan. sara_qmc@hotmail.com
authors: Sara
authors: S
authors: Reza
authors: Asma
authors: A
authors: Shaukat
authors: Tariq M
authors: TM
authors: Arain
authors: Qasim Sarwar
authors: QS
authors: Riaz
authors: Maria
authors: M
authors: Mahmud
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006111:Graves Disease / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D007037:Hypothyroidism / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D011379:Prognosis; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood
chemical_list: D015415:Biomarkers; D053495:Osteopontin; D013972:Thyrotropin; D013974:Thyroxine