title: Acute kidney injury based on corrected serum creatinine is associated with increased morbidity in children following the arterial switch operation.
abstract: OBJECTIVE
  Evaluate risk factors for and impact of acute kidney injury on children following the arterial switch operation.
  
  
  METHODS
  Single-center retrospective chart review.
  
  
  METHODS
  A tertiary children's hospital.
  
  
  METHODS
  A total of 92 patients receiving the arterial switch operation from 1997 to 2008 at severe acute kidney injury was defined as a 100% serum creatinine rise over baseline.
  
  
  RESULTS
  Of 92 patients, 18 (20%) developed severe acute kidney injury. Neither patient age or weight nor cardiopulmonary bypass time correlated with the development of acute kidney injury. Acute kidney injury was associated with the following: higher postoperative day 1 (POD1) fluid balance, higher inotrope scores (POD1 and POD2), and longer: postoperative ICU length of stay (p = 0.005), overall ICU length of stay (p = 0.05), and postoperative hospital length of stay (p = 0.006). The time to peak creatinine for acute kidney injury patients was between POD1 and POD2. Correction of serum creatinine for fluid balance increased the population defined as severe acute kidney injury and strengthened the association of acute kidney injury with postoperative morbidity.
  
  
  CONCLUSIONS
  Acute kidney injury following the arterial switch operation is associated with increased morbidity. In this single center, single population, and homogenous cohort of patients, the development of acute kidney injury was not correlated with age, size, or cardiopulmonary bypass time, but was still associated with prolonged duration of ventilation and hospitalization. Notably, the failure to correct serum creatinine for fluid balance underestimates the prevalence and impact of acute kidney injury.
authors: Center for Acute Care Nephrology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, USA. Rajit.basu@cchmc.org
authors: Rajit K
authors: RK
authors: Basu
authors: Anne
authors: A
authors: Andrews
authors: Catherine
authors: C
authors: Krawczeski
authors: Peter
authors: P
authors: Manning
authors: Derek S
authors: DS
authors: Wheeler
authors: Stuart L
authors: SL
authors: Goldstein
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D000704:Analysis of Variance; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000401:mortality; D003401:Creatine / Q000097:blood*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007231:Infant, Newborn; D007902:Length of Stay; D008297:Male; D009017:Morbidity; D011183:Postoperative Complications / Q000097:blood*; D012189:Retrospective Studies
chemical_list: D003401:Creatine