title: Molecular detection of TT virus and SEN virus infections in hemodialysed patients and blood donors in south of Iran.
abstract: BACKGROUND
  SEN virus (SEN-V) and TT virus (TTV) have been classified in the circoviridae family. Both are single-stranded, non-enveloped DNA viruses of about 3800 nucleotides. Patients on maintenance hemodialysis (HD) have a high risk of blood-borne viral infections. SEN-V and TTV has been reported from a number of HD units from various countries throughout the world.
  
  
  METHODS
  A total of 377 blood samples obtained from 150 healthy donors and 227 HD patients were collected at the HD center. SEN-V and TTV DNA was determined by polymerase chain reaction (PCR) in all samples.
  
  
  RESULTS
  TTV was detected in 109 (48.01%) of 227 hemodialysed patients and 14 (9.33%) of 150 voluntary blood donors (significant, P<0.05). The PCR results for SEN-V-D/H DNA showed that 65 (28.63%) were positive for SEN-V-D and 33 (14.53%) were positive for SEN-V-H. 9.69% of 227 patients were positive for SEN-V-D/H co-infection. In the control group, SEN-V-D was detected in 14 (9.33%) and SEN-V-H was detected in 15 (10%) of the 150 (100%) blood donors.
  
  
  CONCLUSIONS
  These findings show that the prevalence of SEN-V-D/H and TTV is higher than healthy blood donors. Also, these results indicate that the prevalence of SEN-V and TTV infections in our region is similar with that in other countries.
authors: Department of microbiology, Jahrom Branch, Young Researchers Club, Islamic Azad University, Jahrom, Iran.
authors: Rouhi
authors: R
authors: Afkari
authors: Aliyar
authors: A
authors: Pirouzi
authors: Mehdi
authors: M
authors: Mohsenzadeh
authors: Mohammad
authors: M
authors: Azadi
authors: Mohammad
authors: M
authors: Jafari
mesh_terms: D000328:Adult; D001782:Blood Donors; D017848:Blood-Borne Pathogens / Q000302:isolation & purification*; D004266:DNA Virus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D016133:Polymerase Chain Reaction / Q000379:methods; D015995:Prevalence; D006435:Renal Dialysis / Q000009:adverse effects; D022783:Torque teno virus / Q000235:genetics / Q000302:isolation & purification*