title: Closed versus open cell stent for high-risk percutaneous coronary interventions in ST-elevation acute myocardial infarction: the Closed versus Open Cells stent for High risk percutaneous coronary Interventions in ST-Elevation acute myocardial infarction (COCHISE) pilot study.
abstract: BACKGROUND
  Stent deployment may be associated with distal embolization and slow flow in coronary thrombotic lesions. There are no data on the risk of distal thrombus embolization according to the stent design. The aim was to evaluate coronary flow after percutaneous coronary interventions (PCI) in acute myocardial infarction according to the employed stent (closed versus open cell design).
  
  
  METHODS
  From March 2010 to December 2011, 223 consecutive patients with acute ST-elevation myocardial infarction were randomized to primary PCI either with an open cell (112 patients, 88 men) or with a closed cell stent design (111 patients, 92 men). The primary endpoint was the corrected TIMI frame count (cTFC) after the procedure.
  
  
  RESULTS
  There were no significant differences in procedural success nor in-stent deployment in the 2 groups. At baseline, there were no significant differences in cTFC between the 2 groups (70 ± 37 and 67 ± 39, P = .65, respectively). After the procedure, the open cell group showed significantly higher cTFC compared to the closed cell group (18 ± 11 and 15 ± 5, P = .003 respectively). This difference was associated with a significant lower rate of TIMI 3 flow (87% and 95%, P = .037) and myocardial blush grade 3 (65% and 87%, P = .001) in the open compared to the closed cell group. There were 2 cases of death in the open cell and 1 case in the closed cell group.
  
  
  CONCLUSIONS
  The use of a closed cell stent design rather than an open cell during PCI for acute ST-elevation myocardial infarction is associated with better coronary angiographic flow after PCI.
authors: UOC Cardiologia, Policlinico Casilino - ASL RMB, Rome, Italy. alessandro.sciahbasi@fastwebnet.it
authors: Alessandro
authors: A
authors: Sciahbasi
authors: Gianluca
authors: G
authors: Pendenza
authors: Luca
authors: L
authors: Golino
authors: Enrico
authors: E
authors: Romagnoli
authors: Giorgia
authors: G
authors: Caferri
authors: Roberto
authors: R
authors: Patrizi
authors: Francesco
authors: F
authors: Summaria
authors: Francesco
authors: F
authors: Serra
authors: Maria Benedetta
authors: MB
authors: Giannico
authors: Emanuele
authors: E
authors: Bruno
authors: Luigi
authors: L
authors: Sommariva
authors: Ernesto
authors: E
authors: Lioy
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D010865:Pilot Projects; D011474:Prosthesis Design; D015607:Stents; D013927:Thrombosis / Q000000981:diagnostic imaging*; D016896:Treatment Outcome