title: Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy.
abstract: Small-diameter nerve fibers, which subserve nociception, can be affected early in peripheral neuropathies, although their injury may not be detectable by routine neurophysiologic tests. On the other hand, skin biopsy has proved to be a reliable tool to examine nonmyelinated nerve fibers, as assessed by the quantification of intra-epidermal nerve fiber (IENF) density not only along with the degenerative process but, noteworthy, IENF density could be very helpful in evaluating drug efficacy such as erythropoietin (EPO) treatment.
authors: Neuromuscular Diseases Unit, IRCCS Foundation, "Carlo Besta" Neurological Institute, Milan, Italy.
authors: Bianchi
authors: B
authors: Roberto
authors: Lombardi
authors: L
authors: Raffaella
authors: Porretta-Serapiglia
authors: PS
authors: Carla
authors: Lauria
authors: L
authors: Giuseppe
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000503:physiopathology; D004921:Erythropoietin / Q000627:therapeutic use*; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects*; D059225:Nociception / Q000187:drug effects*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004921:Erythropoietin