title: Beneficial effects of a higher-protein breakfast on the appetitive, hormonal, and neural signals controlling energy intake regulation in overweight/obese, "breakfast-skipping," late-adolescent girls.
abstract: BACKGROUND
  Breakfast skipping is a common dietary habit practiced among adolescents and is strongly associated with obesity.
  
  
  OBJECTIVE
  The objective was to examine whether a high-protein (HP) compared with a normal-protein (NP) breakfast leads to daily improvements in appetite, satiety, food motivation and reward, and evening snacking in overweight or obese breakfast-skipping girls.
  
  
  METHODS
  A randomized crossover design was incorporated in which 20 girls [mean ± SEM age: 19 ± 1 y; body mass index (in kg/m(2)): 28.6 ± 0.7] consumed 350-kcal NP (13 g protein) cereal-based breakfasts, consumed 350-kcal HP egg- and beef-rich (35 g protein) breakfasts, or continued breakfast skipping (BS) for 6 d. On day 7, a 10-h testing day was completed that included appetite and satiety questionnaires, blood sampling, predinner food cue-stimulated functional magnetic resonance imaging brain scans, ad libitum dinner, and evening snacking.
  
  
  RESULTS
  The consumption of breakfast reduced daily hunger compared with BS with no differences between meals. Breakfast increased daily fullness compared with BS, with the HP breakfast eliciting greater increases than did the NP breakfast. HP, but not NP, reduced daily ghrelin and increased daily peptide YY concentrations compared with BS. Both meals reduced predinner amygdala, hippocampal, and midfrontal corticolimbic activation compared with BS. HP led to additional reductions in hippocampal and parahippocampal activation compared with NP. HP, but not NP, reduced evening snacking of high-fat foods compared with BS.
  
  
  CONCLUSIONS
  Breakfast led to beneficial alterations in the appetitive, hormonal, and neural signals that control food intake regulation. Only the HP breakfast led to further alterations in these signals and reduced evening snacking compared with BS, although no differences in daily energy intake were observed. These data suggest that the addition of breakfast, particularly one rich in protein, might be a useful strategy to improve satiety, reduce food motivation and reward, and improve diet quality in overweight or obese teenage girls. This trial was registered at clinicaltrials.gov as NCT01192100.
authors: Department of Nutrition and Exercise Physiology, School of Medicine, University of Missouri, Columbia, MO 65201, USA. leidyh@health.missouri.edu
authors: Heather J
authors: HJ
authors: Leidy
authors: Laura C
authors: LC
authors: Ortinau
authors: Steve M
authors: SM
authors: Douglas
authors: Heather A
authors: HA
authors: Hoertel
mesh_terms: D000293:Adolescent; D000328:Adult; D001069:Appetite Regulation / Q000187:drug effects*; D015992:Body Mass Index; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D062408:Breakfast; D018592:Cross-Over Studies; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D004531:Eggs; D002149:Energy Intake; D005260:Female; D005768:Gastrointestinal Hormones / Q000097:blood*; D054439:Ghrelin / Q000097:blood; D006801:Humans; D062407:Meals; D008460:Meat; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D019894:Peptide YY / Q000097:blood; D012527:Satiation; D015398:Signal Transduction; D055815:Young Adult
chemical_list: D004041:Dietary Fats; D004044:Dietary Proteins; D005768:Gastrointestinal Hormones; D054439:Ghrelin; D019894:Peptide YY