title: Inhibitory effects of Olea ferruginea crude leaves extract against some bacterial and fungal pathogen.
abstract: This work aimed to evaluate the inhibitory effects of Olea ferruginea crude leaves extract that are commonly used as remedy to cure infections in the tribal (Khyber Agency) areas of Pakistan against some of bacterial and fungal pathogens. The crude n-hexane fraction was appreciably active against both gram positive and negative microorganisms (MIC ranged from 7.5 to 15 mg/ml) followed by butanol fraction (MIC 15 to 30 mg/ml). Conversely least biological activity was shown by chloroform (30mg/ml) and methanol (15 to 30mg/ml) crude fractions. The MBC observed for all crude fractions was same or 2 times higher when compared with MIC for all crude extract fractions. Likewise all the fractions showed activity against Aspergillus niger and maximum zones of inhibition were shown by the n-hexane fraction (14 ± (0.02), butanol (13 ± (0.02) followed by methanol (9 ± (0.05) and chloroform fractions (7 ± (0.02). These results clearly imitate the antibacterial and antifungal potential of Olea ferruginea and hence we recommend the whole plant for further futuristic studies.
authors: Gomal University, D.I. Khan, Pakistan. dani_amin79@yahoo.com
authors: Adnan
authors: A
authors: Amin
authors: Muhammad Ayaz
authors: MA
authors: Khan
authors: Swahid
authors: S
authors: Shah
authors: Mushatq
authors: M
authors: Ahmad
authors: Muhammad
authors: M
authors: Zafar
authors: Abdul
authors: A
authors: Hameed
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects / Q000254:growth & development; D002725:Chloroform / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D006586:Hexanes / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D031658:Olea / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D010946:Plants, Medicinal; D012997:Solvents / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006586:Hexanes; D010936:Plant Extracts; D012997:Solvents; C026385:n-hexane; D002725:Chloroform; D000432:Methanol