title: Association of six susceptibility Loci with prostate cancer in northern chinese men.
abstract: OBJECTIVE
  Six prostate cancer (PCa) susceptibility loci were identified in a genome-wide association study (GWAS) in populations of European decent. However, the associations of these 6 single-nucleotide polymorphisms (SNPs) with PCa has remained tobe clarified in men in Northern China. This study aimed to explore the loci associated with PCa risk in a Northern Chinese population.
  
  
  METHODS
  Blood samples and clinical information of 289 PCa patients and 288 controls from Beijing and Tianjin were collected. All risk SNPs were genotyped using polymerase chain reaction (PCR)-high resolution melting curve technology and gene sequencing. Associations between PCa and clinical covariates (age at diagnosis, prostate-specific antigen [PSA], Gleason score, tumor stage, and level of aggressiveness) and frequencies of alleles and genotypes of these SNPs were analyzed using genetic statistics.
  
  
  RESULTS
  Among the candidate SNPs, 11p15 (rs7127900, A) was associated with PCa risk (P = 0.02, odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.09-2.46). Genotypes showed differences between cases and controls on 11p15 (rs7127900, A), 11q13 (rs7931342, T), and HNF1B (rs4430796, A) (P = 0.03, P = 0.01, and P = 0.04, respectively). The genotype TG on 11q13 (rs7931342, T) was positively associated with an increased Gleason score (P = 0.04, OR = 2.15, 95% CI = 1.02-4.55). Patients carrying TG on 17q24 (rs1859962, G) were negatively associated with an increased body mass index (BMI) (P = 0.03, OR = 0.44, 95% CI = 0.21-0.92) while those with AG on HNF1B (rs4430796, A) were more likely to have PSA increase (P = 0.002).
  
  
  CONCLUSIONS
  Our study suggests that 11p15 (rs7127900, A) could be a susceptibility locus associated with PCa in Northern Chinese. Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa.
authors: The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors: Yu-Rong
authors: YR
authors: Zhang
authors: Yong
authors: Y
authors: Xu
authors: Kuo
authors: K
authors: Yang
authors: Ming
authors: M
authors: Liu
authors: Dong
authors: D
authors: Wei
authors: Yao-Guang
authors: YG
authors: Zhang
authors: Xiao-Hong
authors: XH
authors: Shi
authors: Jian-Ye
authors: JY
authors: Wang
authors: Fan
authors: F
authors: Yang
authors: Xin
authors: X
authors: Wang
authors: Si-Ying
authors: SY
authors: Liang
authors: Cheng-Xiao
authors: CX
authors: Zhao
authors: Fei
authors: F
authors: Wang
authors: Xin
authors: X
authors: Chen
authors: Liang
authors: L
authors: Sun
authors: Xiao-Quan
authors: XQ
authors: Zhu
authors: Ling
authors: L
authors: Zhu
authors: Yi-Ge
authors: YG
authors: Yang
authors: Lei
authors: L
authors: Tang
authors: Hai-Yan
authors: HY
authors: Jiao
authors: Zheng-Hao
authors: ZH
authors: Huo
authors: Ze
authors: Z
authors: Yang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency / Q000235:genetics; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics*; D012306:Risk; D044465:White People / Q000235:genetics