title: An antibiotic-resistant class 3 integron in an Enterobacter cloacae isolate from hospital effluent.
abstract: Hospital effluents are involved in dissemination of antibiotic-resistant integrons. We describe here a new class 3 integron, In3-5, detected in an Enterobacter cloacae isolate retrieved from a random French hospital effluent sample collected in 2009. In3-5 carries two gene cassettes: the new blaOXA -256 and an aac(6')-Ib variant, respectively conferring resistance to β-lactams and aminoglycosides. In3-5 is located on an IncQ-like backbone plasmid. Class 3 integrons could thus be involved in the dissemination of antibiotic resistance in both clinical settings and the environment, and could participate in the exchange of antibiotic-resistance genes between these two ecosystems.
authors: INSERM U1092, Université de Limoges, Faculté de Médecine, Limoges, France.
authors: O
authors: O
authors: Barraud
authors: M
authors: M
authors: Casellas
authors: C
authors: C
authors: Dagot
authors: M-C
authors: MC
authors: Ploy
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024881:Drug Resistance, Bacterial; D016972:Enterobacter cloacae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D005602:France; D005798:Genes, Bacterial; D006761:Hospitals; D032023:Integrons; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D062065:Wastewater / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D062065:Wastewater