title: [Effects on the pharmacokinetics of furosemide after acute exposure to high altitude at 4010 meters in rats].
abstract: The paper is to report the pharmacokinetics of furosemide in rats living at plain area and high altitude. After intragastric administration of furosemide (2.87 mg x kg(-1)), serial blood samples (0.5 mL) were collected by retro-orbital puncture at 0, 20 min, 40 min, 1, 1.5, 2, 3, 4, 6, 8, 12 and 24 h, samples were determined by LC-MS/MS, and plasma concentration-time data were analyzed by DAS 2.0 software to get the related pharmacokinetic parameters. The main pharmacokinetic parameters: area under curve (AUC), mean residence time (MRT), the biological half-life (t1/2) and the peak concentration (C(max)) of furosemide, were significantly increased at high altitude, the time to reach peak concentration (t(max)) and clearance (CL) was significantly decreased. This study found significant changes on the pharmacokinetics of furosemide under the special environment of high altitude. This finding may provide some references for clinical rational application of furosemide at high altitude.
authors: Key Laboratory of the Plateau of the Environmental Damage Control, General Hospital of Lanzhou Military Command, PLA, Lanzhou 730050, China.
authors: Wen-Bin
authors: WB
authors: Li
authors: Rong
authors: R
authors: Wang
authors: Hua
authors: H
authors: Xie
authors: Juan-Hong
authors: JH
authors: Zhang
authors: Xi-Hui
authors: XH
authors: Xie
authors: Xiao-Yu
authors: XY
authors: Wu
authors: Zheng-Ping
authors: ZP
authors: Jia
mesh_terms: D000284:Administration, Oral; D000531:Altitude; D000818:Animals; D019540:Area Under Curve; D002853:Chromatography, Liquid; D005665:Furosemide / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D006207:Half-Life; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
chemical_list: D005665:Furosemide