title: Acute disseminated encephalomyelitis in two renal transplant patients: is there a role for Epstein-Barr virus reactivation?
abstract: Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system, usually occurring after a vaccination or infectious disease. It has been exceptionally described in transplanted patients. The pathophysiology remains incompletely understood. We report the clinical, biological and magnetic resonance imaging (MRI) presentation and evolution of two kidney-transplanted patients with ADEM associated with local Epstein-Barr virus (EBV) reactivation. ADEM may occur in transplanted patients with favorable evolution. Its pathophysiology is uncertain, and the implication of EBV is discussed.
authors: Department of Neurology, CHU Reims, France.
authors: N
authors: N
authors: Caucheteux
authors: A
authors: A
authors: Maarouf
authors: L
authors: L
authors: Daelman
authors: O
authors: O
authors: Toupance
authors: S
authors: S
authors: Lavaud
authors: A
authors: A
authors: Tourbah
mesh_terms: D004673:Encephalomyelitis, Acute Disseminated / Q000276:immunology* / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000276:immunology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014775:Virus Activation / Q000276:immunology
keywords: Epstein-Barr virus; acute disseminated encephalomyelitis; immunodeficiency; kidney; physiopathology; transplantation