title: Secondary metabolites from Sida rhombifolia L. (Malvaceae) and the vasorelaxant activity of cryptolepinone.
abstract: The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-b-D-glucopyranoside (2a) and stigmasterol-3-O-b-D-glucopyranoside (2b), phaeophytin A (3), 17³-ethoxypheophorbide A (4), 13²-hydroxy phaeophytin B (5), 17³-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by ¹H- and ¹³C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time.
authors: Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil.
authors: Otemberg Souza
authors: OS
authors: Chaves
authors: Roosevelt Albuquerque
authors: RA
authors: Gomes
authors: Anna Cláudia de Andrade
authors: AC
authors: Tomaz
authors: Marianne Guedes
authors: MG
authors: Fernandes
authors: Leônidas
authors: L
authors: das Graças Mendes
authors: Maria
authors: M
authors: de Fátima Agra
authors: Valdir Andrade
authors: VA
authors: Braga
authors: Maria
authors: M
authors: de Fátima Vanderlei de Souza
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000187:drug effects; D019660:Malvaceae / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D014665:Vasodilator Agents / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D014665:Vasodilator Agents