title: Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus.
abstract: Infections with human coronavirus EMC (HCoV-EMC) are associated with severe pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated antiviral alpha/beta interferon (IFN-α/β) responses. However, HCoV-EMC was markedly more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize a broad range of human cell substrates and suppress IFN induction, but it does not reach the IFN resistance of SARS-CoV.
authors: Institute for Virology, Philipps University Marburg, Marburg, Germany.
authors: Florian
authors: F
authors: Zielecki
authors: Michaela
authors: M
authors: Weber
authors: Markus
authors: M
authors: Eickmann
authors: Larissa
authors: L
authors: Spiegelberg
authors: Ali Moh
authors: AM
authors: Zaki
authors: Mikhail
authors: M
authors: Matrosovich
authors: Stephan
authors: S
authors: Becker
authors: Friedemann
authors: F
authors: Weber
mesh_terms: D000818:Animals; D002460:Cell Line; D017934:Coronavirus / Q000276:immunology / Q000502:physiology*; D018352:Coronavirus Infections / Q000276:immunology* / Q000821:virology; D006801:Humans; D007113:Immunity, Innate; D050838:Interferon Regulatory Factor-3 / Q000276:immunology; D007370:Interferon Type I / Q000276:immunology; D011323:Primates; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology / Q000502:physiology*; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology* / Q000821:virology; D056189:Viral Tropism; D014779:Virus Replication
chemical_list: D050838:Interferon Regulatory Factor-3; D007370:Interferon Type I