title: Distribution, frequency and clinical implications of napkin-ring sign assessed by multidetector computed tomography.
abstract: BACKGROUND
  Plaque rupture and secondary thrombus formation play key roles in the onset of acute coronary syndrome (ACS). Plaques showing the napkin-ring sign in multidetector computed tomography (MDCT) have been reported as thin-cap fibroatheroma that is recognized as a precursor lesion for plaque rupture. The purpose of this study was to investigate distribution and frequency of napkin-ring sign and its relationship to features indicating coronary plaque vulnerability on MDCT in patients with coronary artery disease.
  
  
  METHODS
  We enrolled 273 patients with ACS (n=61) or stable angina pectoris (SAP, n=212) who were assessed by MDCT. The definition of the napkin-ring sign was the presence of a ring of high attenuation and the CT attenuation of a ring presenting higher than those of the adjacent plaque and no greater than 130HU.
  
  
  RESULTS
  The culprit plaques with the napkin-ring sign show higher remodeling index and lower CT attenuation (1.15±0.12 vs. 1.02±0.12, p<0.01 and 39.9±22.8 vs. 72.7±26.6, p<0.01, respectively). Napkin-ring sign at culprit lesions was more frequent in patients with ACS than those with SAP (49.0% vs. 11.2%, p<0.01). Moreover, napkin-ring sign at non-culprit lesions was more frequently observed in ACS patients compared with SAP patients (12.7% vs. 2.8%, p<0.01). The distribution of the napkin-ring sign in the right coronary arteries and left circumflex arteries of our population was relatively even, whereas the napkin-ring sign in the left anterior descending artery was common in the proximal sites (p<0.01).
  
  
  CONCLUSIONS
  The napkin-ring sign assessed by MDCT represents similar clinical features of fibroatheroma. MDCT could contribute to the search for fibroatheroma.
authors: Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan. mkashi@wakayama-med.ac.jp
authors: Manabu
authors: M
authors: Kashiwagi
authors: Atsushi
authors: A
authors: Tanaka
authors: Kenei
authors: K
authors: Shimada
authors: Hironori
authors: H
authors: Kitabata
authors: Kenichi
authors: K
authors: Komukai
authors: Tsuyoshi
authors: T
authors: Nishiguchi
authors: Yuichi
authors: Y
authors: Ozaki
authors: Takashi
authors: T
authors: Tanimoto
authors: Takashi
authors: T
authors: Kubo
authors: Kumiko
authors: K
authors: Hirata
authors: Masato
authors: M
authors: Mizukoshi
authors: Takashi
authors: T
authors: Akasaka
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging*; D000368:Aged; D060050:Angina, Stable / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000453:epidemiology*