title: Comparison of the effects of 52 weeks weight loss with either a high-protein or high-carbohydrate diet on body composition and cardiometabolic risk factors in overweight and obese males.
abstract: BACKGROUND
  A high-protein (HP), low-fat weight-loss diet may be advantageous for improving cardiometabolic health outcomes and body composition. To date, only limited research has been conducted in male participants.
  
  
  OBJECTIVE
  To evaluate the medium to long-term effects of two, low-fat, hypocaloric diets differing in carbohydrate:protein ratio on body composition and cardiometabolic health outcomes in overweight and obese males.
  
  
  METHODS
  One hundred and twenty males (age 50.8±9.3 (s.d.) years, body mass index 33.0±3.9 kg m(-2)) were randomly assigned and consumed a low-fat, isocaloric, energy-restricted diet (7 MJ per day) with either HP (protein:carbohydrate:fat %energy, 35:40:25) or high carbohydrate (HC; 17:58:25). Body weight, body composition and cardiometabolic risk factors were assessed at baseline and after 12 and 52 weeks.
  
  
  RESULTS
  Sixty-eight participants completed the study (HP, n=33; HC, n=35). At 1 year both the groups experienced similar reductions in body weight (HP, -12.3±8.0 kg (-12%); HC, -10.9±8.6 kg (-11%); P=0.83 time × group interaction) and fat mass (-9.9±6.0 kg (-27%) vs -7.3±5.8 kg (-22%); P=0.11). Participants who consumed the HP diet lost less fat-free mass (-2.6±3.7 kg (-4%) vs -3.8±4.7 kg (-6%); P<0.01). Both groups experienced similar increases in high-density lipoprotein cholesterol (8%) and reductions in total cholesterol (-7%), low-density lipoprotein cholesterol (-9%), triglycerides (-24%), glucose (-3%), insulin (-38%), blood pressure (-7/-12%) and C-reactive protein (-29%), (P0.14).
  
  
  CONCLUSIONS
  In overweight and obese men, both a HP and HC diet reduced body weight and improved cardiometabolic risk factors. Consumption of a HP diet was more effective for improving body composition compared with an HC diet.
authors: Sansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
authors: T P
authors: TP
authors: Wycherley
authors: G D
authors: GD
authors: Brinkworth
authors: P M
authors: PM
authors: Clifton
authors: M
authors: M
authors: Noakes