title: Association between C-reactive protein, pro-oxidant-antioxidant balance and traditional cardiovascular risk factors in an Iranian population.
abstract: BACKGROUND
  Inflammatory states are known to cause an imbalance in the redox status. We aimed to study the possible associations between pro-oxidant-antioxidant balance (PAB) and serum high-sensitive C-reactive protein (hs-CRP) concentrations and traditional cardiovascular disease (CVD) risk factors in an unselected Iranian population and in groups of individuals with specific disease.
  
  
  METHODS
  The study was conducted among an unselected population of 758 male subjects. Biochemical markers, including hs-CRP and PAB values, were measured.
  
  
  RESULTS
  Serum hs-CRP concentrations were positively associated with serum PAB values (r = 0.260, P ≤ 0.001). Univariate analysis showed that PAB values were statistically higher in individuals who were obese or smokers compared with non-obese and non-smokers individuals (P < 0.01). While serum hs-CRP concentrations were significantly higher in older subjects, subjects with obesity, diabetes mellitus, metabolic syndrome, central obesity, hypertriglyceridaemia, higher low-density lipoprotein cholesterol concentrations, positive history of CVD and lower physical activity than subjects without these risk factors (P < 0.05). Comparing hs-CRP and PAB values in different CVD risk score subgroups showed a significant incremental rise in both parameters as CVD risk score increased (P < 0.05). Using multiple linear regression analysis we found a strong association between PAB values and hs-CRP concentrations.
  
  
  CONCLUSIONS
  This study showed that among Iranian subjects, the inflammatory marker, hs-CRP, was strongly and positively associated with a marker of oxidative stress and also with several traditional risk factors of CVD. Moreover, the impact of traditional cardiovascular risk factors on hs-CRP concentrations and PAB values differed.
authors: Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Science, 9196773117, Mashhad, Iran.
authors: Akramosadat
authors: A
authors: Razavi
authors: Mohammad Reza
authors: MR
authors: Baghshani
authors: Amir Ali
authors: AA
authors: Rahsepar
authors: Hossein
authors: H
authors: Mohaddes Ardabili
authors: Mohammad Sobhan
authors: MS
authors: Sheikh Andalibi
authors: Seyyed Mohammad
authors: SM
authors: Reza Parizadeh
authors: Shima
authors: S
authors: Tavallaie
authors: Somayeh
authors: S
authors: Mousavi
authors: Majid
authors: M
authors: Ghayour-Mobarhan
authors: Gordon
authors: G
authors: Ferns
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species; D002097:C-Reactive Protein