title: Effectiveness of a double-carbapenem regimen for infections in humans due to carbapenemase-producing pandrug-resistant Klebsiella pneumoniae.
abstract: Ertapenem plus doripenem or meropenem were given in three patients suffering from pandrug-resistant, KPC-2-positive Klebsiella pneumoniae bacteremia (2 patients) and urinary tract infection (1 patient), respectively. All responded successfully, without relapse at follow-up. The results obtained should probably be attributed to ertapenem's increased affinity for the carbapenemases hindering doripenem/meropenem degradation in the environment of the microorganism.
authors: 6th Department of Internal Medicine, Hygeia General Hospital, Athens, Greece. e.giamarellou@hygeia.gr
authors: Helen
authors: H
authors: Giamarellou
authors: Lambrini
authors: L
authors: Galani
authors: Fotini
authors: F
authors: Baziaka
authors: Ilias
authors: I
authors: Karaiskos
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D015780:Carbapenems / Q000494:pharmacology*; D000077726:Doripenem; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D000077727:Ertapenem; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development; D008297:Male; D000077731:Meropenem; D008875:Middle Aged; D013845:Thienamycins / Q000494:pharmacology*; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D004338:Drug Combinations; D013845:Thienamycins; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams; D000077726:Doripenem; D001618:beta-Lactamases; C063912:carbapenemase; D000077731:Meropenem; D000077727:Ertapenem