title: Soluble tag-assisted peptide head-to-tail cyclization: total synthesis of mahafacyclin B.
abstract: A soluble tag-assisted liquid-phase method was successfully applied to peptide head-to-tail cyclization, leading to the total synthesis of antimalarial cyclic heptapeptide, mahafacyclin B (1). The cyclization was carried out in the liquid phase with the tag remaining, which allowed rapid reaction workup and product isolation.
authors: Department of Applied Biological Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
authors: Yuko
authors: Y
authors: Fujita
authors: Shuji
authors: S
authors: Fujita
authors: Yohei
authors: Y
authors: Okada
authors: Kazuhiro
authors: K
authors: Chiba
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003500:Cyclization; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D010456:Peptides, Cyclic; C512387:mahafacyclin B