title: Fetal and neonatal outcomes in women taking domperidone during pregnancy.
abstract: The safety of domperidone in pregnancy remains unknown. Therefore, the study aimed to prospectively evaluate the fetal outcomes of women who were taking domperidone during pregnancy. In a prospective cohort study design, 120 1st- trimester pregnant women who were taking domperidone for controlling gastrointestinal tract symptoms and 212 age-matched pregnant women not exposed to any potential teratogenic agent, were followed-up until delivery. In the case group, domperidone was indicated for control of functional gastrointestinal disorders in 59.2%, the maximum dose was 30 mg/day and exposure occurred between 2(+4) and 20 weeks' gestation. Fetal outcomes including gestational age at birth, birth weight and length, head circumference at birth, and 1- and 5-min Apgar score were similar in the two study groups. There were three babies born with malformations in each group (OR = 0.6; 95% CI 0.1, 2.8). In conclusion, domperidone does not appear to be a major human teratogen. However, our findings require further confirmation in larger studies.
authors: The Korean Motherisk Program, Cheil General Hospital and Women's Healthcare Centre, Kwandong University, College of Medicine, Seoul, Republic of Korea.
authors: J-S
authors: JS
authors: Choi
authors: J-Y
authors: JY
authors: Han
authors: H-K
authors: HK
authors: Ahn
authors: H-M
authors: HM
authors: Ryu
authors: M-Y
authors: MY
authors: Kim
authors: J-H
authors: JH
authors: Yang
authors: A A
authors: AA
authors: Nava-Ocampo
authors: G
authors: G
authors: Koren
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000328:Adult; D000932:Antiemetics / Q000009:adverse effects*; D001724:Birth Weight / Q000187:drug effects*; D004294:Domperidone / Q000009:adverse effects*; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D000932:Antiemetics; D004294:Domperidone