title: Selective reduction of PHA biopolyesters and their synthetic analogues to corresponding PHA oligodiols proved by structural studies.
abstract: A highly selective method is described for controlling the degradation of polyhydroxyalkanoates, PHA, via a reduction reaction that uses lithium borohydride. Using this method, oligo(hydroxyalkanoate)diols derived from a poly(3-hydroxybutyrate-co-4-hydroxybutyrate) biopolyester [poly(3HB-co-4HB)] and from synthetic atactic poly[(R,S)-3-hydroxybutyrate] (a-PHB) were obtained. The structural characterization of the oligo(hydroxyalkanoate)diols was conducted using NMR and ESI-mass spectrometry analyses, which confirmed that oligomers that were terminated by two hydroxyl end groups were formed. The reduction of the ester groups occurred in a statistical way regardless of the chemical structure of the comonomer units or of the microstructure of the polyester chain. The presented method can be used to synthesize various PHA oligodiols that are potentially useful in the further synthesis of tailor-made biodegradable materials.
authors: Centre of Polymer and Carbon Materials, Polish Academy of Sciences , 34, M. Curie-Skłodowska Street, 41-819 Zabrze, Poland.
authors: Michał
authors: M
authors: Kwiecień
authors: Grażyna
authors: G
authors: Adamus
authors: Marek
authors: M
authors: Kowalczuk
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D001894:Borohydrides / Q000737:chemistry; D018020:Lithium Compounds / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D054813:Polyhydroxyalkanoates / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D001672:Biocompatible Materials; D001894:Borohydrides; D018020:Lithium Compounds; D011091:Polyesters; D054813:Polyhydroxyalkanoates; C040936:lithium borohydride