title: Expression of p53 protein after nonablative rejuvenation: the other side of the coin.
abstract: BACKGROUND
  Disturbance of p53 expression may play an important role in the pathogenesis of ultraviolet (UV) light-induced skin cancer as well as photoaging.
  
  
  OBJECTIVE
  To objectively evaluate the potential effect of nonablative facial rejuvenation on p53 expression.
  
  
  METHODS
  Thirty patients with Fitzpatrick skin type III to IV were divided into five groups. Each group underwent a different nonablative modality: radiofrequency (RF), intense pulsed light (IPL), electro-optical synergy (ELOS) (combined RF and IPL), 1,320-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, and 2,940-nm erbium-doped (Er):YAG laser minipeel. Skin biopsies were obtained before treatment, by the end of treatment, and 3 months after treatment. Biopsies were also taken from 30 controls. Quantitative evaluation of p53 was performed using computer image analysis for immunostained tissues.
  
  
  RESULTS
  P53 expression was statistically significantly greater at the end of IPL (p = .02) and ELOS (p = .02) treatments than before treatment but was statistically insignificantly lower (p > .05) 3 months after treatment than at the end of treatment. No significant differences (p > .05) were observed in p53 level after RF, 1,320-nm Nd:YAG, and 2,940-nm Er:YAG mini-peel treatments from baseline.
  
  
  CONCLUSIONS
  The increase in epidermal p53 expression after IPL treatment could increase the risk of skin neoplasia by intense pulsed light-induced DNA damage which may lead to dysregulation of apoptosis and initiation of skin cancer.
authors: Department of Dermatology, Al-Minya University, Al-Minya, Egypt. moetazeldomyati@yahoo.com
authors: Moetaz
authors: M
authors: El-Domyati
authors: Tarek S
authors: TS
authors: El-Ammawi
authors: Walid
authors: W
authors: Medhat
authors: Osama
authors: O
authors: Moawad
authors: Mỹ G
authors: MG
authors: Mahoney
authors: Jouni
authors: J
authors: Uitto
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003357:Cosmetic Techniques / Q000009:adverse effects*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012060:Rejuvenation / Q000502:physiology*; D012878:Skin Neoplasms / Q000209:etiology*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D055815:Young Adult
chemical_list: D016159:Tumor Suppressor Protein p53