title: Multiple targeted drugs carrying biodegradable membrane barrier: anti-adhesion, hemostasis, and anti-infection.
abstract: A multiple targeted drug carrying bilayer membrane for preventing an abdominal adhesion is prepared by electrospinning. Two bioactive drugs were successfully incorporated into this bilayer membrane and can be independently released from nanofibrous scaffolds without losing structural integrity and functionality of the anti-adhesion membrane. Besides, the drug release profile could be easily adjusted by optimizing the swelling behavior of the fibrous scaffold. The inner layer of the bilayered fibrous membranes loaded with carbazochrome sodium sulfonate (CA) showed an excellent vascular hemostatic efficacy and formed little clot during in vivo experiment. The outer layer loaded with tinidazole (TI) had outstanding antibacterial effect against the anaerobe. We believe this approach could serve as a model technique to guide the design of implants with drug delivery functions.
authors: State Key Laboratory of Polymer Physics and Chemistry, Joint Laboratory of Polymer Science and Materials, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
authors: Heran
authors: H
authors: Wang
authors: Min
authors: M
authors: Li
authors: Jianming
authors: J
authors: Hu
authors: Chenhong
authors: C
authors: Wang
authors: Shanshan
authors: S
authors: Xu
authors: Charles C
authors: CC
authors: Han
mesh_terms: D000323:Adrenochrome / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems; D015195:Drug Design; D004343:Drug Implants; D004926:Escherichia coli / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D019344:Lactic Acid; D008051:Lipid Bilayers / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D011092:Polyethylene Glycols / Q000737:chemistry; D011098:Polyglactin 910 / Q000737:chemistry; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014011:Tinidazole / Q000737:chemistry / Q000378:metabolism; D000267:Tissue Adhesions / Q000188:drug therapy / Q000517:prevention & control*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D004343:Drug Implants; D008051:Lipid Bilayers; C102418:poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer; D014011:Tinidazole; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011098:Polyglactin 910; D011092:Polyethylene Glycols; D000323:Adrenochrome; C073338:carbazochrome