title: [Evaluation of TSH cutoff value in blood-spot samples in neonatal screening for the diagnosis of congenital hypothyroidism in the Programa "Primeiros Passos" - IEDE/RJ].
abstract: OBJECTIVE
  To analyze the confirmed or not-confirmed cases of neonatal screening (CH) screened in the Programa "Primeiros Passos", stratifying them into TSH blood-spot (TSH-BS) ranges.
  
  
  METHODS
  To stratify, in ranges of TSH-BS as a function of TSH serum (TSH-S), the cases called for a confirmatory test from January, 2006 to July, 2009.
  
  
  RESULTS
  Around 37% of the confirmed cases (475) showed TSH-F > 9.5 mUi/L, but most of the confirmed cases were in lower TSH-F ranges. Among the unconfirmed cases (4,613), most were found in the lower ranges. There was no TSH-F range exclusive to unconfirmed cases.
  
  
  CONCLUSIONS
  TSH-BS cutoff value used is crucial in the diagnosis of CH and should be low, even if more confirmatory tests are performed. More studies are needed to determine the best cutoff value of TSH-BS for neonatal screening.
authors: Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione (IEDE), Rio de Janeiro, RJ, Brasil. bbarone@terra.com.br
authors: Bianca
authors: B
authors: Barone
authors: Clarisse Lourandes da Silva
authors: CL
authors: Lopes
authors: Latife Salomão
authors: LS
authors: Tyszler
authors: Valéria Borges
authors: VB
authors: do Amaral
authors: Rosa Helena C
authors: RH
authors: Zarur
authors: Valéria Neto
authors: VN
authors: Paiva
authors: Denise Boechat
authors: DB
authors: Leite
authors: Ricardo M R
authors: RM
authors: Meirelles
mesh_terms: D015415:Biomarkers / Q000097:blood; D001938:Brazil; D003409:Congenital Hypothyroidism / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D009313:National Health Programs; D015997:Neonatal Screening / Q000379:methods*; D012016:Reference Values; D012189:Retrospective Studies; D013972:Thyrotropin / Q000097:blood*
chemical_list: D015415:Biomarkers; D013972:Thyrotropin