title: Receptor-based targeting of therapeutics.
abstract: Receptor-based targeting of therapeutics may be a fascinating proposition to improve the therapeutic efficacy of encapsulated drugs. The development of safe and effective nanomedicines is a prerequisite in the current nanotechnological scenario. Currently, the surface engineering of nanocarriers has attracted great attention for targeted therapeutic delivery by selective binding of targeting ligand to the specific receptors present on the surface of cells. In this review, we have discussed the current status of various receptors such as transferrin, lectoferrin, lectin, folate, human EGF receptor, scavenger, nuclear and integrin, which are over-expressed on the surface of cancer cells; along with the relevance of targeted delivery systems such as nanoparticles, polymersomes, dendrimers, liposomes and carbon nanotubes. The review also focuses on the effective utilization of receptor-based targeted delivery systems for the management of cancer in effective ways by minimizing the drug-associated side effects and improving the therapeutic efficacy of developed nano-architectures.
authors: Department of Pharmaceutical Sciences, Dr HS Gour University, Sagar, India.
authors: Neelesh Kumar
authors: NK
authors: Mehra
authors: Vijay
authors: V
authors: Mishra
authors: Narendra K
authors: NK
authors: Jain
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D066246:ErbB Receptors / Q000187:drug effects; D006801:Humans; D018960:Hyaluronan Receptors / Q000187:drug effects; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*; D011956:Receptors, Cell Surface / Q000187:drug effects*; D054411:Receptors, Leptin / Q000187:drug effects; D011990:Receptors, Transferrin / Q000187:drug effects; D018124:Receptors, Tumor Necrosis Factor / Q000187:drug effects
chemical_list: D018960:Hyaluronan Receptors; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D011990:Receptors, Transferrin; D018124:Receptors, Tumor Necrosis Factor; C038340:lactoferrin receptors; D066246:ErbB Receptors