title: Novel nanoporous bioceramic spheres for drug delivery application: a preliminary in vitro investigation.
abstract: BACKGROUND
  Bioceramics and their composites have found myriad applications in medicine as superlative osteoalloplasts. Their potential to function as a biocompatible resorbable drug delivery system is being explored. The present study is a preliminary investigation into the efficacy of these indigenously developed nanoporous materials as vehicles for therapeutic agents. An in vitro experiment was conducted with the goal of assessing this material and comparing it with a commercially available gentamicin-loaded polymethylmethacrylate cement.
  
  
  METHODS
  The drug-eluting characteristics of gentamicin bone cement and indigenously designed nanoporous bioceramic granules were analyzed spectrophotometrically and compared. Regression analysis was done.
  
  
  RESULTS
  The first 5 days saw the elute from both samples containing drug concentrations >100 μg/g.
  
  
  CONCLUSIONS
  Both samples exhibit a high initial-burst release, which is ideal for prophylactic purposes. Drug eluent levels for both materials were >100 μg/g, which is sufficient for bactericidal activity.
authors: Sri Chithra Thirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India. simondeepti@yahoo.co.in
authors: Deepti
authors: D
authors: Simon
authors: Suvy
authors: S
authors: Manuel
authors: Harikrishna
authors: H
authors: Varma
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry; D002516:Ceramics / Q000138:chemical synthesis / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004058:Diffusion; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D008422:Materials Testing; D008863:Microspheres; D049329:Nanostructures / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D016062:Porosity; D013053:Spectrophotometry; D013499:Surface Properties; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D003692:Delayed-Action Preparations; D005839:Gentamicins; D011142:Polyvinyl Alcohol; D019904:Polymethyl Methacrylate; D017886:Durapatite