title: New Anti-Inflammatory Aromatic Components from  Antrodia camphorata.
abstract: Three new benzenoids, 3-isopropenyl-2-methoxy-6-methyl-4,5-methylenedioxy- phenol (1), 2-hydroxy-4,4'-dimethoxy-3,3'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (2), 4,4'-dihydroxy-3,3'-dimethoxy-2,2'-dimethyl-5,6,5',6'-bimethylenedioxybiphenyl (3), together with two known benzenoids, 2,3,6-trimethoxy-5-methylphenol (4) and 2,3-methylenedioxy- 4-methoxy-5-methylphenol (5), were isolated from Antrodia camphorata. Our results support that compounds 1-5 potently inhibited LPS (lipopolysaccharide)-induced nitric oxide (NO) production in a dose-dependent manner. The IC(50) values of compounds 1, 3 and 5 were 1.8 ± 0.2, 18.8 ± 0.6 and 0.8 ± 0.3 μg/mL, respectively.
authors: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources,  College of Pharmacy, China Medical University, Taichung 404, Taiwan. kuoyh@mail.cmu.edu.tw.
authors: Yu-Chang
authors: YC
authors: Chen
authors: His-Lin
authors: HL
authors: Chiu
authors: Che-Yi
authors: CY
authors: Chao
authors: Wen-Hsin
authors: WH
authors: Lin
authors: Louis Kuoping
authors: LK
authors: Chao
authors: Guan-Jhong
authors: GJ
authors: Huang
authors: Yueh-Hsiung
authors: YH
authors: Kuo