title: Photoreceptor degeneration in mice: adeno-associated viral vector-mediated delivery of erythropoietin.
abstract: The exogenous delivery of erythropoietin (EPO) and EPO derivatives (EPO-Ds) represents a valuable strategy to protect the retina from degeneration. In this chapter we describe a method to deliver EPO and the EPO derivative S100E in the light-damage model of induced retinal degeneration using adeno--associated viral (AAV) vectors and to evaluate the functional and morphological protection of the retina from light damage.
authors: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.
authors: Pasqualina
authors: P
authors: Colella
authors: Alberto
authors: A
authors: Auricchio
mesh_terms: D000818:Animals; D000229:Dependovirus / Q000235:genetics*; D004921:Erythropoietin / Q000235:genetics*; D005822:Genetic Vectors / Q000235:genetics*; D051379:Mice; D010786:Photoreceptor Cells / Q000473:pathology*; D012162:Retinal Degeneration / Q000235:genetics / Q000378:metabolism* / Q000628:therapy
chemical_list: D004921:Erythropoietin