title: [Clinical study of invasive fungal infection secondary to systemic lupus erythematosus].
abstract: OBJECTIVE
  To study the clinical characteristics of invasive fungal infection secondary to systemic lupus erythematosus (SLE).
  
  
  METHODS
  We observed the clinical features and experimental examination in 91 patients treated in Xiangya Hospital in recent years, of which 48 patients with invasive fungal infection and 41 patients without invasive fungal infection.
  
  
  RESULTS
  The invasive fungal infection secondary to SLE mainly occurred in the lungs, nervous system, and urinary system. The fungi were mainly Candida albins and Aspergillus. The rate of invasive fungal infection in SLE patients and the level of CRP and TNF-α in these patients were significantly increased. The occurrence of invasive fungal infection was positively correlated with the prolonged course of disease, long-term use of immunosuppressants and antibiotics, and occurrence of complications, such as hypoproteinemia, leukocytopenia, and so on. The levels of C-reactive protein (CRP) and tumor necrosis factor-α(TNF-α) were increased in SLE patients with invasive fungal infection.
  
  
  CONCLUSIONS
  The clinical features of SLE patients with invasive fungal infections are long course of disease, long-time use of immunosuppressants or antibiotics, and occurrence of complications, such as hypoproteinemia or leukopenia. The level of CRP and TNF-α can be used as an important reference index for diagnosing invasive fungal infections.
authors: Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China.
authors: Hongxiang
authors: H
authors: Deng
authors: Yunhui
authors: Y
authors: You
authors: Ping
authors: P
authors: Liu
authors: Hongjun
authors: H
authors: Zhao
authors: Ya'ou
authors: Y
authors: Zhou
authors: Yanli
authors: Y
authors: Xie
authors: Xiaoxia
authors: X
authors: Zuo
mesh_terms: D000293:Adolescent; D000328:Adult; D001230:Aspergillus / Q000302:isolation & purification; D002097:C-Reactive Protein / Q000378:metabolism; D002176:Candida albicans / Q000302:isolation & purification; D020314:Central Nervous System Fungal Infections / Q000453:epidemiology; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000150:complications*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein