title: Predictive factors of overall well-being using the EORTC QLQ-C15-PAL extracted from the EORTC QLQ-C30.
abstract: OBJECTIVE
  The European Organization of Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire - Core 15 Palliative (EORTC QLQ-C15-PAL) was developed to assess quality of life (QOL) for the palliative cancer population to decrease patient burden. The purpose of this study was to compare predictive factors for well-being in the QLQ-C15-PAL extracted from the EORTC Quality of Life Questionnaire - Core 30 (QLQ-C30) with the QLQ-C30 itself.
  
  
  METHODS
  Patients with advanced cancer referred for treatment of bone metastases completed the QLQ-C30. Fifteen items from the QLQ-C15-PAL were extracted from the QLQ-C30. Univariate and multivariate analyses were used to determine predictive factors of the global QOL/health score in both tools. In the multivariate analyses, a p value of <0.003 indicated statistical significance.
  
  
  RESULTS
  Overall, predictive factors were similar when analyzing data from both tools. Predictive factors for the QLQ-C30 were role functioning (p<0.0001), fatigue (p<0.0001), nausea/vomiting (p<0.0001), and financial problems (p<0.0001) and factors for the extracted QLQ-C15-PAL were physical functioning (p<0.0001) and fatigue (p<0.0001).
  
  
  CONCLUSIONS
  Extraction of the QLQ-C15-PAL items from the QLQ-C30 resulted in similar predictive QOL domains for all patient subgroups analyzed individually. The QLQ-C15-PAL is reflective of the QLQ-C30 domains and is recommended for future studies involving patients in a palliative setting, as this shorter questionnaire reduces patient burden and may increase accrual and compliance, while maintaining a similar breadth of coverage and achieving the same predictive ability.
authors: Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Kinsey
authors: K
authors: Lam
authors: Liang
authors: L
authors: Zeng
authors: Liying
authors: L
authors: Zhang
authors: Ling-Ming
authors: LM
authors: Tseng
authors: Ming-Feng
authors: MF
authors: Hou
authors: Alysa
authors: A
authors: Fairchild
authors: Vassilios
authors: V
authors: Vassiliou
authors: Reynaldo
authors: R
authors: Jesus-Garcia
authors: Mohamed A
authors: MA
authors: Alm El-Din
authors: Aswin
authors: A
authors: Kumar
authors: Fabien
authors: F
authors: Forges
authors: Wei-Chu
authors: WC
authors: Chie
authors: Arjun
authors: A
authors: Sahgal
authors: Michael
authors: M
authors: Poon
authors: Edward
authors: E
authors: Chow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009369:Neoplasms; D010166:Palliative Care; D010549:Personal Satisfaction; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires / Q000592:standards*