title: Clinically meaningful responses to sequential gemcitabine-based chemotherapy regimens in a patient with metastatic pancreatic cancer.
abstract: Pancreatic cancer exhibits profound chemoresistance resulting either from pre-existing (intrinsic) mechanisms, or from anticancer drug treatment itself (acquired chemoresistance). We present the case of a patient with pancreatic adenocarcinoma metastatic to the liver who experienced clinical, radiographic and tumor marker response to three lines of gemcitabine-based chemotherapy. The regimens included: 8 cycles of gemcitabine and oxaliplatin (GEMOX), 8 cycles of gemcitabine, docetaxel and capecitabine (GTX) and more than 3 cycles of gemcitabine and nab-paclitaxel, with an exceptional response 2 years from the initiation of chemotherapy for metastatic pancreatic cancer.
authors: Cancer Treatment Centers of America, Philadelphia, Pa., USA.
authors: Eiko
authors: E
authors: Klimant
authors: Maurie
authors: M
authors: Markman
authors: Daniela M
authors: DM
authors: Albu
keywords: Best responders to gemcitabine, pancreatic cancer; Naturopathic regimens, pancreatic cancer; Pancreatic cancer, response to chemotherapy; Pharmacogenomics of gemcitabine, pancreatic adenocarcinoma; Second- and third-line gemcitabine-based chemotherapy, pancreatic carcinoma