title: The role of autoantibodies in autoimmune hepatitis type 2.
abstract: Antibodies play an important role in autoimmune liver diseases, such as autoimmune hepatitis (AIH). On the one hand, they are essential diagnostic markers to identify not only the presentation of AIH, but also the AIH subtype characterized by the presence of particular antibodies to target autoantigens in the liver. On the other hand, such autoantibodies might be directly involved in the etiology and/or pathogenesis of AIH. This review will reflect on the evidence of how specific autoantibodies influence AIH and will further provide insight into the necessities for generating therapeutic antibodies to treat AIH in the future.
authors: Pharmazentrum Frankfurt/ZAFES, Goethe University Hospital Frankfurt, Theodor-Stern Kai 7, 60590 Frankfurt am Main, Germany. christen@med.uni-frankfurt.de
authors: Urs
authors: U
authors: Christen
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology / Q000627:therapeutic use; D001324:Autoantigens / Q000276:immunology; D003577:Cytochrome P-450 Enzyme System / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D019693:Hepatitis, Autoimmune / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018716:Molecular Mimicry
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D003577:Cytochrome P-450 Enzyme System; C509164:CYP2D7 protein, human