title: Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats.
abstract: This study hypothesized that modification of titanium implant surface, e.g. by the deposition of inorganic/organic coatings, can significantly improve the implant-bone response compared in osteoporotic vs. healthy conditions. After osteoporosis was induced in 15 female Wistar rats by ovariectomy (OVX) and confirmed by in vivo micro-CT analysis, implants coated with calcium phosphate (CaP) or collagen type-I and non-coated implants were placed into bilateral femoral condyles. Another 15 sham-operated rats served as controls. Twelve weeks after implantation, micro-CT bone volume (%BV) and histomorphometrical bone area (%BA) were lower around control implants in osteoporotic rats (BV = 60.4%, BA = 43.8%) compared to sham-operated rats (BV = 74.0%, BA = 62.0%). Interestingly, CaP and collagen type-I surface coatings enhanced bone-to-implant contact (%BIC) compared to non-coated implants in osteoporosis (51.9%, 58.2%) as well as in sham-operated (69.7%, 64.4%) groups. The study confirmed that an osteoporotic condition has a significant effect on the amount of bone present in close vicinity to implants. Evidently, the use of osteogenic surface coatings has a favorable effect on the bone implant interface in both osteoporotic and sham-operated conditions.
authors: Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. h.alghamdi@dent.umcn.nl
authors: Hamdan S
authors: HS
authors: Alghamdi
authors: Ruggero
authors: R
authors: Bosco
authors: Jeroen J J P
authors: JJ
authors: van den Beucken
authors: X Frank
authors: XF
authors: Walboomers
authors: John A
authors: JA
authors: Jansen
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D002130:Calcium Phosphates / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D024042:Collagen Type I / Q000494:pharmacology*; D005260:Female; D020007:Implants, Experimental; D009929:Organ Size / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D014025:Titanium / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects; D055114:X-Ray Microtomography
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D024042:Collagen Type I; C020243:calcium phosphate; D014025:Titanium