title: Platelets, photosensitizers, and PDT.
abstract: Photodynamic therapy (PDT) has both direct cell and indirect vascular effects. Both are well established and the latter has given rise to specifically target angiogenesis in PDT treatments. While the vascular effects are well understood, further advances in anti-angiogenesis require a detailed understanding of PDT effects at the microvasculature level. Although some of the earliest investigations of PDT noted effects on platelet aggregation the importance of their interaction with endothelial cells and the crucial role of various signaling pathways is only now emerging. This review aims to give a general overview of PDT related studies on platelets, vascular effects, and their interaction with endothelial cells to indicate the potential for studies in this area.
authors: Medicinal Chemistry, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland. sengem@tcd.ie
authors: Mathias O
authors: MO
authors: Senge
authors: Marek W
authors: MW
authors: Radomski
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D042783:Endothelial Cells / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D006801:Humans; D008027:Light; D010778:Photochemotherapy / Q000639:trends*; D017319:Photosensitizing Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*
chemical_list: D017319:Photosensitizing Agents