title: A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.
abstract: Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.
authors: Department of Chemistry, Texas Christian University, 2800 S. University, Ft. Worth, USA.
authors: Kimberly M
authors: KM
authors: Lincoln
authors: Paulina
authors: P
authors: Gonzalez
authors: Timothy E
authors: TE
authors: Richardson
authors: David A
authors: DA
authors: Julovich
authors: Ryker
authors: R
authors: Saunders
authors: James W
authors: JW
authors: Simpkins
authors: Kayla N
authors: KN
authors: Green
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D053961:Azabicyclo Compounds / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D008970:Molecular Weight; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013329:Structure-Activity Relationship; D028561:Transition Elements / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D053961:Azabicyclo Compounds; D009942:Organometallic Compounds; D017382:Reactive Oxygen Species; D028561:Transition Elements; C582723:pyclen