title: "Nanogold detoxifying machine" to remove idle nanogold particles from blood stream of cancer patients treated with antibody-nanogold therapeutics.
abstract: This hypothesis would help to elevate safety in nanogold-therapy of some cancers. It has no previous record in published media and there is no existing protocol for what is expressed in this paper. The hypothesis makes some experimental recommendations for future research at the interface of nanotechnology and biological systems. It is about reducing toxicity and side effects of nanogold particles (NGPs) in cancer patients treated with antibody-nanogold therapeutics. The hypothesis expresses that how to eliminate idle NGPs from blood stream of treated cancer patients in order to reduce undesirable deposition and accumulation of NGPs in non-target tissues and organs in post therapy. In this regard, at the end of therapy period, blood of treated cancer patient which contains idle nanogold-antibodies is passed through a machine named "Nanogold detoxifying machine" (NDM). This machine behaves like "hemodialysis machine" used for patients with lost kidney function but, instead of dialysis membrane, NDM is equipped with impermeable membrane containing nanotubes to which cancer specific-antigens (CSAs) are attached. While blood circulates in NDM, CSAs attract and immobilize the idle nanogold-antibodies. Implementation of NDM clears patient's blood from idle nanogold-antibodies which were not attached to their targets, the cancer cells. Elimination of idle NGPs from blood would minimize side effects resulting from their deposition or accumulation on non-target cells or tissues. Since NDM reduces anxieties about side effects, it would provide patients with better feelings too. NDM would enhance efficacy of NGPs targeted toward specific cancers. Before using it for clinical trials in human cases, NDM should pass animal evaluations; however, research works should optimize its implementation. I think NDM method holds great promise to reduce the time, effort, and expense in cancer research, screening, detection, and therapy.
authors: Kerman University of Medical Sciences, International Campus, Kerman, Iran. shahidil@ymail.com
authors: Leyla Shahidi
authors: LS
authors: Bonjar
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001781:Blood Component Removal / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006046:Gold / Q000302:isolation & purification* / Q000627:therapeutic use*; D006440:Hemofiltration / Q000295:instrumentation*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D036103:Nanotechnology / Q000295:instrumentation; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy*
chemical_list: D000911:Antibodies, Monoclonal; D006046:Gold