title: Correlates of 25-hydroxyvitamin D and breast cancer stage in the Women's Healthy Eating and Living Study.
abstract: Inverse associations between circulating 25-hydroxyvitamin D [25(OH)D] and breast cancer stage have been reported, thus it is critical to understand the variables that contribute to 25(OH)D levels among women with breast cancer. Among 904 women in the Women's Healthy Eating and Living Study, plasma 25(OH)D concentrations were measured and data on demographic characteristics, diet, physical activity, and tumor characteristics were collected at study entry. Statistically significant associations with 25(OH)D concentrations were observed for body mass index (BMI), body surface area (BSA), height, smoking, total vitamin D intake, physical activity, and race or ethnicity. Of the correlates of 25(OH)D, BMI, BSA, height, physical activity, and study site were associated with stage of breast cancer; however, concentrations of 25(OH)D were not significantly related to stage. In fully adjusted logistic regression models, the ORs (95% CIs) for the association between vitamin D deficiency and Stage II and III cancers were 0.85 (0.59-1.22) and 1.23 (0.71-2.15), respectively (P trend = 0.59), compared to Stage I. This study confirms previous work regarding the correlates of 25(OH)D concentrations but does not provide support for an association between vitamin D status and breast cancer stage.
authors: Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona 85724-5024, USA. jacobse@u.arizona.edu
authors: Elizabeth T
authors: ET
authors: Jacobs
authors: Cynthia A
authors: CA
authors: Thomson
authors: Shirley W
authors: SW
authors: Flatt
authors: Vicky A
authors: VA
authors: Newman
authors: Cheryl L
authors: CL
authors: Rock
authors: John P
authors: JP
authors: Pierce
mesh_terms: D000328:Adult; D000368:Aged; D001130:Arizona; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood* / Q000209:etiology / Q000473:pathology*; D002140:California; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009922:Oregon; D012044:Regression Analysis; D013781:Texas; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D