title: Preventive effects of multi-lamellar emulsion on low potency topical steroid induced local adverse effect.
abstract: BACKGROUND
  Topical steroid treatment induces diverse local Wand systemic adverse effects. Several approaches have been tried to reduce the steroid-induced adverse effects. Simultaneous application of physiological lipid mixture is also suggested.
  
  
  OBJECTIVE
  Novel vehicles for topical glucocorticoids formulation were evaluated for the efficacy of reducing side-effects and the drug delivery properties of desonide, a low potency topical steroid.
  
  
  METHODS
  Transcutaneous permeation and skin residual amount of desonide were measured using Franz diffusion cells. The in vivo anti-inflammatory activity was evaluated using murine model.
  
  
  RESULTS
  Topical steroids formulation containing desonide, in either cream or lotion form, were prepared using multi-lamellar emulsion (MLE), and conventional desonide formulations were employed for comparison. MLE formulations did not affect the anti-inflammatory activity of the desonide in phobol ester-induced skin inflammation model, compared with conventional formulations. While the penetrated amounts of desonide were similar for all the tested formulations at 24 hours after application, the increased lag time was observed for the MLE formulations. Interestingly, residual amount of desonide in epidermis was significantly higher in lotion type MLE formulation. Steroid-induced adverse effects, including permeability barrier function impairment, were partially prevented by MLE formulation.
  
  
  CONCLUSIONS
  Topical desonide formulation using MLE as a vehicle showed a better drug delivery with increased epidermal retention. MLE also partially prevented the steroid-induced side effects, such as skin barrier impairment.
authors: Department of Biology Education, Korea National University of Education, Cheongwon, Korea.
authors: Geun Dong
authors: GD
authors: Sul
authors: Hyun Jung
authors: HJ
authors: Park
authors: Jong Hwan
authors: JH
authors: Bae
authors: Keum Duck
authors: KD
authors: Hong
authors: Byeong Deog
authors: BD
authors: Park
authors: Jaesun
authors: J
authors: Chun
authors: Se Kyoo
authors: SK
authors: Jeong
authors: Seung Hun
authors: SH
authors: Lee
authors: Sung Ku
authors: SK
authors: Ahn
authors: Hyun Jung
authors: HJ
authors: Kim
keywords: Epidermal permeability barrier function; Multilamellar emulsion; Skin permeation; Topical glucocorticoids