title: Signaling via MYD88 in the pancreatic tumor microenvironment: A double-edged sword.
abstract: We have recently shown that Toll-like receptor (TLR) signaling exacerbates pancreatic fibro-inflammation and promotes carcinogenesis in mice. Paradoxically, inhibition of the TLR-MYD88 signaling pathway is pro-tumorigenic owing to the dendritic cell-mediated TH2-polarization of CD4+T cells. TLR signaling appears to be central in pancreatic cancer-associated inflammation.
authors.affiliation: Department of Surgery; S. Arthur Localio Laboratory; New York University School of Medicine; New York, NY USA.
authors.forename: Constantinos P
authors.initials: CP
authors.lastname: Zambirinis
authors.forename: George
authors.initials: G
authors.lastname: Miller
keywords: MYD88; Toll-like receptors; cancer-associated inflammation; dendritic cells; innate immunity; pancreatic cancer; pattern-recognition receptors; tumor microenvironment