title: Gene expression profiling and molecular pathway analysis for the identification of early-stage lung adenocarcinoma patients at risk for early recurrence.
abstract: Clinicohistopathological staging is insufficient to predict disease progression and clinical outcome in lung carcinoma. Based on the results of the principal component analysis of 24 samples of early-stage lung adenocarcinoma, two subgroups were identified within the early-relapse group. The histological classification of all samples of group A was poorly differentiated, whereas one out of three in group B was poorly differentiated. DAVID functional annotation analysis revealed that the molecular pathways enriched in group A included those associated with cell adhesion molecules (CAMs), cell cycle and antigen processing and presentation, whereas those in group B included CAMs, T cell receptor signaling, cytokine-cytokine receptor interaction, toll-like receptor signaling, chemokine signaling, primary immunodeficiency and natural killer cell-mediated cytotoxicity. The CAM pathway was enriched in both groups. This comprehensive gene expression and functional pathway analysis identified a distinct molecular pathway, CAMs, that correlated with the early relapse of patients with early-stage lung adenocarcinoma.
authors.affiliation: Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan. saji-q@ya2.so-net.ne.jp
authors.forename: Hisashi
authors.initials: H
authors.lastname: Saji
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tsuboi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Shimada
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Kato
authors.forename: Wakako
authors.initials: W
authors.lastname: Hamanaka
authors.forename: Yujin
authors.initials: Y
authors.lastname: Kudo
authors.forename: Koichi
authors.initials: K
authors.lastname: Yoshida
authors.forename: Jun
authors.initials: J
authors.lastname: Matsubayashi
authors.forename: Jitsuo
authors.initials: J
authors.lastname: Usuda
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ohira
authors.forename: Norihiko
authors.initials: N
authors.lastname: Ikeda
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D017951:Antigen Presentation; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D002453:Cell Cycle / Q000235:genetics; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000378:metabolism; D018121:Receptors, Cytokine / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D016207:Cytokines; D018121:Receptors, Cytokine; D051193:Toll-Like Receptors