title: Proteomics imaging and the kidney.
abstract: Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are advanced technologies capable of revealing the spatial distribution of different molecules--e.g., drugs and their metabolites, endogenous lipids and complex peptides/proteins--directly in tissue specimens at the same time. Information obtained regarding tissues by MALDI profiling/imaging analysis can be correlated with other MS-based techniques, auxiliary imaging technologies and routine immunohistochemical stainings. In this review we describe the MALDI profiling/imaging technologies, providing examples of their application in kidney research.
authors.affiliation: Department of Health Science, University of Milano-Bicocca, Monza, Italy. fulvio.magni@unimib.it
authors.forename: Fulvio
authors.initials: F
authors.lastname: Magni
authors.forename: Maciej
authors.initials: M
authors.lastname: Lalowski
authors.forename: Veronica
authors.initials: V
authors.lastname: Mainini
authors.forename: Martina
authors.initials: M
authors.lastname: Marchetti-Deschmann
authors.forename: Clizia
authors.initials: C
authors.lastname: Chinello
authors.forename: Andrea
authors.initials: A
authors.lastname: Urbani
authors.forename: Marc
authors.initials: M
authors.lastname: Baumann
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000737:chemistry*; D057054:Molecular Imaging / Q000379:methods; D040901:Proteomics / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization