title: Attenuation of the insulin amyloid aggregation in presence of Fe3O4-based magnetic fluids.
abstract: Presence of protein amyloid deposits is associated with pathogenesis of amyloid-related diseases. Insulin amyloid aggregates have been reported in a patient with diabetes undergoing treatment by injection of insulin. We have investigated the interference of insulin amyloid aggregation with two Fe3O4-based magnetic fluids. The magnetic fluids are able to inhibit insulin amyloid fibrillization and promote disassembly of amyloid fibrils. The cytotoxic effect of amyloid fibrils is attenuated in presence of magnetic fluids probably due to reduction of the fibrils. We suggest that present findings propose the potential use of Fe3O4-based magnetic fluids as the therapeutic agents targeting insulin-associating amyloidosis.
authors.affiliation: Institute of Experimental Physics, Slovak Academy of Sciences, Košice, Slovak Republic.
authors.forename: Katarina
authors.initials: K
authors.lastname: Siposova
authors.forename: Eva
authors.initials: E
authors.lastname: Bystrenova
authors.forename: Andrea
authors.initials: A
authors.lastname: Antosova
authors.forename: Martina
authors.initials: M
authors.lastname: Koneracka
authors.forename: Vlasta
authors.initials: V
authors.lastname: Zavisova
authors.forename: Peter
authors.initials: P
authors.lastname: Kopcansky
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Gazova
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005290:Ferric Compounds / Q000737:chemistry* / Q000528:radiation effects / Q000633:toxicity*; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D007328:Insulin / Q000737:chemistry*; D007928:Lethal Dose 50; D060526:Magnetic Fields; D012996:Solutions
chemical_list: D000682:Amyloid; D005290:Ferric Compounds; D007328:Insulin; D012996:Solutions; C000499:ferric oxide