title: Triphosgene-amine base promoted chlorination of unactivated aliphatic alcohols.
abstract: Unactivated α-branched primary and secondary aliphatic alcohols have been successfully transformed into their corresponding alkyl chlorides in high yields upon treatment with a mixture of triphosgene and pyridine in dichloromethane at reflux. These mild chlorination conditions are high yielding, stereospecific, and well tolerated by numerous sensitive functionalities. Furthermore, no nuisance waste products are generated in the course of the reactions.
authors.affiliation: Department of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, Louisiana 70803, USA.
authors.forename: Andrés
authors.initials: A
authors.lastname: Villalpando
authors.forename: Caitlan E
authors.initials: CE
authors.lastname: Ayala
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Watson
authors.forename: Rendy
authors.initials: R
authors.lastname: Kartika