title: Burden of illness and factors associated with duration of illness in clinical campylobacteriosis.
abstract: A population-based study investigated the burden of illness, including the duration of illness associated with laboratory-confirmed cases of campylobacteriosis in two health unit areas. Questionnaire data were collected for 250 cases. The median duration of illness was 8 days and 66% of cases reported symptoms of moderate severity or greater. A Cox proportional hazards model identified antimicrobial use factors associated with a significantly increased rate of symptom resolution (shorter duration of illness): macrolides for less than the recommended number of days, ciprofloxacin for at least 3 days, and antimicrobials not recommended for campylobacteriosis. The impact of antimicrobial use was consistent regardless of when, during the course of illness, the antimicrobial use began. The effectiveness of ciprofloxacin in these results may be due to the low prevalence of resistance to ciprofloxacin in isolates from this study. The effect of antimicrobials not recommended for campylobacteriosis should be further investigated.
authors.affiliation: Population Medicine, University of Guelph, Guelph, Ontario, Canada.
authors.forename: A E
authors.initials: AE
authors.lastname: Deckert
authors.forename: R J
authors.initials: RJ
authors.lastname: Reid-Smith
authors.forename: S
authors.initials: S
authors.lastname: Tamblyn
authors.forename: L
authors.initials: L
authors.lastname: Morrell
authors.forename: P
authors.initials: P
authors.lastname: Seliske
authors.forename: F B
authors.initials: FB
authors.lastname: Jamieson
authors.forename: R
authors.initials: R
authors.lastname: Irwin
authors.forename: C E
authors.initials: CE
authors.lastname: Dewey
authors.forename: P
authors.initials: P
authors.lastname: Boerlin
authors.forename: S A
authors.initials: SA
authors.lastname: McEwen
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002169:Campylobacter Infections / Q000188:drug therapy* / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D017281:Cost of Illness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011795:Surveys and Questionnaires; D013997:Time Factors; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents