title: Transcriptional regulation and its misregulation in disease.
abstract: The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.
authors.affiliation: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
authors.forename: Tong Ihn
authors.initials: TI
authors.lastname: Lee
authors.forename: Richard A
authors.initials: RA
authors.lastname: Young
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics*; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D022661:RNA, Untranslated