title: L28. Relevance of detection techniques for ANCA testing.
abstract: ANCA are a good serologic marker for AAV, especially for GPA and MPA. Today, the best diagnostic performance is obtained when indirect immunofluorescence test is combined with antigen-specific assay. The new developed more sensitive and specific methods for ANCA detection in AAV, which may replace the need for a combined analysis with IFT and ELISA in the future, should be evaluated in multicentre studies. ANCA testing can be improved by restricting the use of the tests to clinical situations with a rather high pretest probability for AAV, and carefully searching for conditions such as drug exposures and infections that are known to be associated with the occurrence of ANCA, whether the vasculitis is present or not. Therefore, a rational strategy for ANCA testing is needed and the International consensus statement on testing of ANCA should urgently be revised.
authors.affiliation: Medical University Luebeck, Department of Rheumatology, Klinikum Bad Bramstedt, Germany. csernok@klinikumbb.de
authors.forename: Csernok
authors.initials: C
authors.lastname: Elena
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D001706:Biopsy; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D008403:Mass Screening; D053146:Myeloblastin / Q000276:immunology; D009195:Peroxidase / Q000276:immunology; D011237:Predictive Value of Tests
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D000939:Epitopes; D009195:Peroxidase; D053146:Myeloblastin