title: Synergistic interaction of ferulic acid with commercial hypoglycemic drugs in streptozotocin induced diabetic rats.
abstract: Diabetes mellitus is a chronic disorder characterized by increased blood glucose level. The available commercial oral antidiabetic drugs have some serious side effects; hence there is a need for new hypoglycemic agents which will have therapeutic efficacy as well as less side effects. Ferulic acid, a phytochemical, might be a good supplement to manage diabetes. We investigated the antidiabetic and antilipidemic effect of ferulic acid alone and in combination with oral antidiabetic drugs (metformin and Thiazolidinedione (THZ)). Blood glucose, plasma lipid profiles levels, liver function and kidney function markers were measured in control and streptozotocin induced diabetic rats three weeks after administrating ferulic acid and OHDs (oral hypoglycemic drugs) alone and in combinations. The histopathological analysis of the pancreas was also carried out. Ferulic acid and OHDs significantly reduced the blood glucose, lipid profile, urea, creatinine, serum glutamic pyruvic transaminases (SGPT) and serum glutamic oxaloacetate transaminases (SGOT) in diabetic rats. Same level of reduction in blood glucose levels was achieved when ferulic acid was used in combination with even reduced amounts of OHDs. It decreased most of the side effects when used in combination with THZ. Histopathological analysis showed that combinations increased the number of islets. Ferulic acid interacts synergistically with both the drugs. It might be a good supplement with the OHDs to manage diabetic complications as well as reduces the use of the later.
authors.affiliation: Lovely Faculty of Applied Medical Sciences, LPU, Phagwara 144402, India.
authors.forename: Pranav Kumar
authors.initials: PK
authors.lastname: Prabhakar
authors.forename: Ram
authors.initials: R
authors.lastname: Prasad
authors.forename: Shakir
authors.initials: S
authors.lastname: Ali
authors.forename: Mukesh
authors.initials: M
authors.lastname: Doble
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003373:Coumaric Acids / Q000494:pharmacology / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D045162:Thiazolidinediones / Q000494:pharmacology / Q000627:therapeutic use*; D014508:Urea / Q000097:blood
chemical_list: D001786:Blood Glucose; D003373:Coumaric Acids; D007004:Hypoglycemic Agents; D008055:Lipids; D010936:Plant Extracts; D045162:Thiazolidinediones; D014508:Urea; D008687:Metformin; C004999:ferulic acid; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase