title: A new dehydroabietic acid-based arylamine fluorescent probe: Synthesis, structure analysis and in vitro biodiagnose function.
abstract: A new fluorescent probe (methyl 13-(α-naphthalene)aminodeisopropyldehydroabietate) has been synthesized, and its structure was optimized by theoretical DFT calculation and determinated by single-crystal X-ray diffraction analysis. The optimized data are in agreement with the experimental values. The fluorescence properties, photostability, cell toxicity and in vitro fluorescence imaging of the compound have been investigated. The results indicated that it can be effectively taken up by HeLa, 7721, 7901 and A549 cells and strong blue fluorescence signals were detected in these cells.
authors.affiliation: Institute of Chemical Industry of Forestry Products, CAF, National Engineering Lab. for Biomass Chemical Utilization, Key Lab. of Biomass Energy and Material, Jiangsu Province, 16 Suojin Wucun, Nanjing 210042, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Gao
authors.forename: Shanshan
authors.initials: S
authors.lastname: Chen
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Rao
authors.forename: Shibin
authors.initials: S
authors.lastname: Shang
authors.forename: Zhanqian
authors.initials: Z
authors.lastname: Song
mesh_terms: D045784:Abietanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011789:Quantum Theory; D013050:Spectrometry, Fluorescence
chemical_list: D045784:Abietanes; D000588:Amines; D005456:Fluorescent Dyes; C583675:methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate; C013913:dehydroabietic acid