title: Functional polymorphism in the CAV1 T29107A gene and its association with prostate cancer risk among Japanese men.
abstract: OBJECTIVE
  To evaluate the relationship between the Caveolin-1 (CAV1) T29107A (rs7804372) polymorphism and the risk of prostate cancer among Japanese populations, and the associations between CAV1 polymorphisms and clinicopathological characteristics, including Gleason grade and prostate-specific antigen (PSA) grade.
  
  
  METHODS
  We recruited 134 patients with prostate cancer and 86 healthy controls matched for age and smoking status. The CAV1 T29107A polymorphism status was determined by polymerase chain reaction and restriction fragment-length polymorphism analysis.
  
  
  RESULTS
  Genotype distributions (p=0.0045) and allelic frequencies (p=0.0018) differed between prostate cancer and control groups in terms of the CAV1 T29107A polymorphism (Pearson's χ(2) test). Logistic regression analysis of case and control outcomes showed an odds ratio of 0.35 (95% Condifence interval=0.13-0.91, p=0.033) between the TT and AA polymorphisms, indicating a reduced risk of prostate cancer to be associated with the AA polymorphism. Subset analysis revealed no significant associations between this polymorphism and clinicopathological characteristics of prostate cancer.
  
  
  CONCLUSIONS
  The results of this study demonstrated a relationship between the CAV1 T29107A variant and risk of prostate cancer. This polymorphism thus, merits further investigation as a potential genomic marker for the early detection of prostate cancer. Our results support the hypothesis that the CAV1 T29107A (rs7804372) polymorphism may influence susceptibility to prostate cancer; however, prostate cancer progression was not associated with this polymorphism in a Japanese population.
authors.affiliation: Department of Urology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake-cho, Miyazaki 889-1692, Japan. sugi5255@fc.miyazaki-u.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Sugie
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Tsukino
authors.forename: Takenori
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Mukai
authors.forename: Masato
authors.initials: M
authors.lastname: Fujii
authors.forename: Norihiko
authors.initials: N
authors.lastname: Shibata
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kamoto
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D051242:Caveolin 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D012306:Risk
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1