title: Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3+regulatory T cells and are associated with poor prognosis in breast cancer patients.
abstract: The accumulation of plasmacytoid dendritic cells (pDCs) within breast carcinoma lesions is associated with a poor clinical outcome. We demonstrated that the deleterious impact of tumor-associated pDCs (TApDCs) is due to their impaired capacity to produce Type I interferon, which in turn potentiates their ability to sustain the proliferation of immunosuppressive regulatory T cells.
authors.affiliation: Université de Lyon; Lyon, France ; Université Lyon 1; ISPB; Lyon, France ; INSERM U1052; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; CNRS UMR5286; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; LabEx DEVweCAN; Lyon, France ; Centre Léon Bérard; Lyon, France.
authors.forename: Vanja
authors.initials: V
authors.lastname: Sisirak
authors.forename: Julien
authors.initials: J
authors.lastname: Faget
authors.forename: Nelly
authors.initials: N
authors.lastname: Vey
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Blay
authors.forename: Christine
authors.initials: C
authors.lastname: Ménétrier-Caux
authors.forename: Christophe
authors.initials: C
authors.lastname: Caux
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bendriss-Vermare
keywords: breast cancer; immunosuppression; plasmacytoid dendritic cells; regulatory T cells; tolerance