title: Indoles synthesized from amines via copper catalysis.
abstract: N-substituted indoles are synthesized from primary amines through a tandem reaction sequence. Initial condensation of the amine with an α-(o-haloaryl)ketone or aldehyde is followed by intramolecular aryl amination catalyzed by CuI. A variety of anilines and alkyl amines, including those with significant steric demands, are converted to indoles in high yields and with varying indole substitution.
authors.affiliation: Department of Chemistry, University of Houston, 136 Fleming Building, Houston, Texas 77204-5003, United States.
authors.forename: Ronald
authors.initials: R
authors.lastname: Besandre
authors.forename: Miguel
authors.initials: M
authors.lastname: Jaimes
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: May
mesh_terms: D000586:Amination; D000588:Amines / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000588:Amines; D000814:Aniline Compounds; D007211:Indoles; D003300:Copper; C023650:aniline