title: Genome architecture: domain organization of interphase chromosomes.
abstract: The architecture of interphase chromosomes is important for the regulation of gene expression and genome maintenance. Chromosomes are linearly segmented into hundreds of domains with different protein compositions. Furthermore, the spatial organization of chromosomes is nonrandom and is characterized by many local and long-range contacts among genes and other sequence elements. A variety of genome-wide mapping techniques have made it possible to chart these properties at high resolution. Combined with microscopy and computational modeling, the results begin to yield a more coherent picture that integrates linear and three-dimensional (3D) views of chromosome organization in relation to gene regulation and other nuclear functions.
authors.affiliation: MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH42XU, UK. wendy.bickmore@igmm.ed.ac.uk
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Bickmore
authors.forename: Bas
authors.initials: B
authors.lastname: van Steensel
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism; D002467:Cell Nucleus / Q000235:genetics*; D022004:Chromosome Structures; D002875:Chromosomes / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007399:Interphase; D034881:Nuclear Lamina / Q000378:metabolism