title: Trichodermaerin, a new diterpenoid lactone from the marine fungus Trichoderma erinaceum associated with the sea star Acanthaster planci.
abstract: Trichodermaerin (1), a novel diterpenoid lactone, together with the known compound, harziandione (2) were isolated from the culture broth of the fungus Trichoderma erinaceum associated with the sea star Acanthaster planci. Their structures were determined by analysis of the NMR and MS data. 1 was the Baeyer-Villiger monooxygenase catalyzed oxidation product of 2. Compound 2 did not show cytotoxic activities against various cancer cell lines.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China.
authors.forename: Zhong-Liang
authors.initials: ZL
authors.lastname: Xie
authors.forename: Hou-Jin
authors.initials: HJ
authors.lastname: Li
authors.forename: Lai-You
authors.initials: LY
authors.lastname: Wang
authors.forename: Wan-Ling
authors.initials: WL
authors.lastname: Liang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Lan
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D061986:MCF-7 Cells; D015394:Molecular Structure; D013215:Starfish / Q000382:microbiology*; D014242:Trichoderma / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D007783:Lactones; C579667:trichodermaerin