title: A retrospective study of autologous stem cell mobilization to guide an immediate salvage protocol using plerixafor for patients who mobilize stem cells poorly.
abstract: The addition of plerixafor to G-CSF decreases the risk of failed stem cell collection, but at considerable extra cost. Using a logistic regression model based on 354 autologous mobilizations, we have identified a local minimum peripheral blood CD34 count at which the probability of a successful collection is 50%. This seems an appropriate CD34 count at which to add immediate salvage plerixafor.
authors.affiliation: Department of Haematology, NHS Grampian, Scotland; NCIC Clinical Trials Group, Kingston, Canada.
authors.forename: Annette Elizabeth
authors.initials: AE
authors.lastname: Hay
authors.forename: Alastair
authors.initials: A
authors.lastname: Lawrie
authors.forename: Nicolas
authors.initials: N
authors.lastname: Robinson
authors.forename: Bin
authors.initials: B
authors.lastname: Dong
authors.forename: Dominic J
authors.initials: DJ
authors.lastname: Culligan
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D001596:Benzylamines; D001781:Blood Component Removal; D001835:Body Weight; D003362:Cost-Benefit Analysis; D000080027:Cyclams; D016179:Granulocyte Colony-Stimulating Factor / Q000191:economics / Q000627:therapeutic use; D019650:Hematopoietic Stem Cell Mobilization / Q000191:economics / Q000379:methods*; D006571:Heterocyclic Compounds / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008223:Lymphoma / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D009101:Multiple Myeloma / Q000628:therapy*; D012044:Regression Analysis; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000191:economics / Q000379:methods*; D014182:Transplantation, Autologous / Q000191:economics / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor
keywords: apheresis; cost-effectiveness; lymphoma; myeloma; transplant