title: Mulberry leaf reduces oxidation and C-reactive protein level in patients with mild dyslipidemia.
abstract: C-reactive protein (CRP) is the inflammatory marker that could represent the inflammation in blood vessels resulted from dyslipidemia. The objective of this study was to evaluate the antioxidative activity of mulberry leaf powder using DPPH assay and the effect of mulberry leaf powder on lipid profile, CRP level, and antioxidative parameters in mild dyslipidemia patients. A within-subjects design was conducted and patients received three tablets of 280 mg mulberry leaf powder three times a day before meals for 12 weeks. Total of 25 patients were enrolled but one subject was excluded. After three months of mulberry leaf consumption, serum triglyceride and low-density lipoprotein (LDL) level were significantly reduced and more than half of all patients' CRP levels decreased every month as well as the mean CRP level but no statistically significant difference was found. The average erythrocyte glutathione peroxidase activity of patients was increased but not at significant level; however, the mean serum 8-isoprostane level was significantly lower after mulberry treatment for 12 weeks. It can be concluded that mulberry leaf powder exhibited antioxidant activity and mulberry leaf powder has potential to decrease serum triglyceride, LDL, and CRP levels in mild dyslipidemia patients without causing severe adverse reactions.
authors.affiliation: Bioactive Resources for Innovative Clinical Applications Research Unit, and Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, PhayaThai Road, Phatumwan, Bangkok 10330, Thailand. aramwit@gmail.com
authors.forename: Pornanong
authors.initials: P
authors.lastname: Aramwit
authors.forename: Ouppatham
authors.initials: O
authors.lastname: Supasyndh
authors.forename: Tippawan
authors.initials: T
authors.lastname: Siritienthong
authors.forename: Nipaporn
authors.initials: N
authors.lastname: Bang
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D002097:C-Reactive Protein / Q000378:metabolism*; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D031625:Morus; D010084:Oxidation-Reduction / Q000187:drug effects; D008517:Phytotherapy; D018515:Plant Leaves; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002097:C-Reactive Protein; D005979:Glutathione Peroxidase