title: Imaging mass spectrometry-based molecular histology differentiates microscopically identical and heterogeneous tumors.
abstract: Many tumors display significant cellular heterogeneity as well as molecular heterogeneity. Sensitive biomarkers that differentiate between diagnostically challenging tumors must contend with this heterogeneity. Mass spectrometry-based molecular histology of a patient series of heterogeneous, microscopically identical bone tumors highlighted the tumor cell types that could be characterized by a single profile and led to the identification of specific peptides that differentiate between the tumors.
authors.affiliation: Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center , Leiden, The Netherlands.
authors.forename: Emrys A
authors.initials: EA
authors.lastname: Jones
authors.forename: Nicole
authors.initials: N
authors.lastname: Schmitz
authors.forename: Cathelijn J F
authors.initials: CJ
authors.lastname: Waaijer
authors.forename: Christian K
authors.initials: CK
authors.lastname: Frese
authors.forename: Alexandra
authors.initials: A
authors.lastname: van Remoortere
authors.forename: René J M
authors.initials: RJ
authors.lastname: van Zeijl
authors.forename: Albert J R
authors.initials: AJ
authors.lastname: Heck
authors.forename: Pancras C W
authors.initials: PC
authors.lastname: Hogendoorn
authors.forename: André M
authors.initials: AM
authors.lastname: Deelder
authors.forename: A F Maarten
authors.initials: AF
authors.lastname: Altelaar
authors.forename: Judith V M G
authors.initials: JV
authors.lastname: Bovée
authors.forename: Liam A
authors.initials: LA
authors.lastname: McDonnell
mesh_terms: D000595:Amino Acid Sequence; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology*; D002813:Chondrosarcoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D057054:Molecular Imaging / Q000379:methods; D008969:Molecular Sequence Data; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry