title: Oral and genital HPV genotypic concordance between sexual partners.
abstract: OBJECTIVE
  The aim of this study was to verify human papillomavirus (HPV) transmission and genotype concordance among heterosexual couples.
  
  
  METHODS
  Thirty-one married couples were evaluated. All male subjects presented with clinically diagnosed HPV-related malignant or potentially malignant lesions and underwent peniscopy and penile swab. Their female counterparts underwent swabs of the uterine cervix and oral mucosa. HPV-DNA detection was performed by polymerase chain reaction and restriction fragment length polymorphism.
  
  
  RESULTS
  HPV-DNA was detected in the penis, vagina/cervix, and oral cavity of 16 couples (51.61%). Of these, HPV-DNA concordance was observed in 14 couples (87.5%). HPV-DNA was amplified in penile and oral sites of 14 couples. Of these, 13 couples reported fellatio (92.85%), most of them (10 couples, 76.9%) without condom use. HPV-DNA concordance was observed in 7/10 of these couples (70%). The three couples (100%) who reported use of condom during fellatio were HPV-DNA discordant (p = 0.025).
  
  
  CONCLUSIONS
  Lifetime number of female sexual partners and detection of HPV-DNA in the penile mucosa are surrogate markers of exposure to HPV during marriage. Consistent use of condoms may reduce the risk of HPV transmission.
  
  
  CONCLUSIONS
  Oral acquisition of HPV from oro-genital contact is influenced by lack of condom use and previous sexual behavior of the male partner. In addition, oral transmission of the virus due to fellatio is as common as genital transmission.
authors.affiliation: Departamento de Clinica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Camila Maria
authors.initials: CM
authors.lastname: Beder Ribeiro
authors.forename: Iracema
authors.initials: I
authors.lastname: Ferrer
authors.forename: Andreza Barkokebas
authors.initials: AB
authors.lastname: Santos de Farias
authors.forename: Débora Diniz
authors.initials: DD
authors.lastname: Fonseca
authors.forename: Igor Henrique
authors.initials: IH
authors.lastname: Morais Silva
authors.forename: Luiz Alcino
authors.initials: LA
authors.lastname: Monteiro Gueiros
authors.forename: Alessandra Tavares
authors.initials: AT
authors.lastname: Carvalho
authors.forename: Stephen Ross
authors.initials: SR
authors.lastname: Porter
authors.forename: Jair Carneiro
authors.initials: JC
authors.lastname: Leao
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000235:genetics*; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D005836:Genitalia, Female / Q000821:virology*; D005837:Genitalia, Male / Q000821:virology*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000821:virology*; D016133:Polymerase Chain Reaction; D012747:Sexual Partners; D055815:Young Adult
chemical_list: D017931:DNA Primers