title: Circadian disruption leads to loss of homeostasis and disease.
abstract: The relevance of a synchronized temporal order for adaptation and homeostasis is discussed in this review. We present evidence suggesting that an altered temporal order between the biological clock and external temporal signals leads to disease. Evidence mainly based on a rodent model of "night work" using forced activity during the sleep phase suggests that altered activity and feeding schedules, out of phase from the light/dark cycle, may be the main cause for the loss of circadian synchrony and disease. It is proposed that by avoiding food intake during sleep hours the circadian misalignment and adverse consequences can be prevented. This review does not attempt to present a thorough revision of the literature, but instead it aims to highlight the association between circadian disruption and disease with special emphasis on the contribution of feeding schedules in circadian synchrony.
authors.affiliation: Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, 04360 Mexico City, DF, Mexico.
authors.forename: Carolina
authors.initials: C
authors.lastname: Escobar
authors.forename: Roberto
authors.initials: R
authors.lastname: Salgado-Delgado
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gonzalez-Guerra
authors.forename: Araceli
authors.initials: A
authors.lastname: Tapia Osorio
authors.forename: Manuel
authors.initials: M
authors.lastname: Angeles-Castellanos
authors.forename: Ruud M
authors.initials: RM
authors.lastname: Buijs