title: Factors affecting surgical margin positivity in invasive ductal breast cancer patients who underwent breast-conserving surgery after preoperative core biopsy diagnosis.
abstract: OBJECTIVE
  The aim of our study is to evaluate the factors affecting surgical margin positivity among patients with invasive ductal breast cancer who underwent breast-conserving surgery (BCS) after preoperative diagnostic core biopsy.
  
  
  METHODS
  Two hundred sixteen patients with stage I, II invasive ductal breast carcinoma who had histological diagnosis with preoperative tru-cut biopsy and underwent BCS were included in the present study. Potential factors that affect the positive surgical margin were analyzed. In univariate analysis, the comparisons of the factors affecting the surgical margin positivity were made by chi-square test. Logistic regression test was used to detect the independent factors affecting the surgical margin positivity.
  
  
  RESULTS
  Positive axillary lymph node (odds ratio [OR], 8.2; 95% confidence interval [CI], 3.01 to 22.12), lymphovascular invasion (LVI; OR, 3.9; 95% CI, 1.62 to 9.24), extensive intraductal component (EIC; OR, 6.1; 95% CI, 2.30 to 16.00), presence of spiculation (OR, 5.1; 95% CI, 2.00 to 13.10) or presence of microcalcification in the mammography (OR, 13.7; 95% CI, 4.04 to 46.71) have been found to be the independent and adverse factors affecting surgical margin positivity.
  
  
  CONCLUSIONS
  Considering decision making for the extent of the excision and for achieving negative surgical margin before BCS, positive axillary lymph node, LVI, EIC, spiculation or microcalcification in mammography are related as predictor factors for positive surgical margin.
authors.affiliation: Department of General Surgery, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Koca
authors.forename: Bekir
authors.initials: B
authors.lastname: Kuru
authors.forename: Savas
authors.initials: S
authors.lastname: Yuruker
authors.forename: Barıs
authors.initials: B
authors.lastname: Gokgul
authors.forename: Necati
authors.initials: N
authors.lastname: Ozen
keywords: Breast ductal carcinoma; Large-core needle biopsy; Segmental mastectomy