title: Neurotrophin 3 genotype and emotional adverse effects of osmotic-release oral system methylphenidate (OROS-MPH) in children with attention-deficit/hyperactivity disorder.
abstract: Neurotrophin 3 (NTF3) has been studied in relation to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD) and mood disorders as well as psychostimulant action. We hypothesized that the risk of an emotional side effect to methylphenidate (MPH) treatment may be associated with NTF3 genotypes. Ninety-six medication-naïve children with ADHD (mean age 8.70, standard deviation 1.41 years, 79 males) were genotyped and treated with MPH. At baseline, which was prior to MPH treatment, and after two weeks of medication, investigators asked children and their parents or caregivers about adverse events using a symptom rating scale. ADHD subjects with the A/A genotype at the NTF3 rs6332 polymorphism showed the highest 'Emotionality' and 'Over-focus/euphoria' factor scores, followed by those with the G/A genotype and those with the G/G genotype (p=0.042 and p=0.045, respectively). ADHD subjects with the A/A genotype at the NTF3 rs6332 polymorphism showed the highest 'Proneness to crying' and 'Nail biting' item scores, followed by those with the G/A genotype and those with the G/G genotype (p=0.047 and p=0.017, respectively). These data provide preliminary evidence that genetic variation in the NTF3 gene is related to susceptibility to emotional side effects in response to MPH treatment in Korean children with ADHD.
authors.affiliation: 1Department of Child and Adolescent Psychiatry, Seoul National University Hospital, Seoul, Korea.
authors.forename: Subin
authors.initials: S
authors.lastname: Park
authors.forename: Bung-Nyun
authors.initials: BN
authors.lastname: Kim
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Min-Sup
authors.initials: MS
authors.lastname: Shin
authors.forename: Soo-Churl
authors.initials: SC
authors.lastname: Cho
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Jung-Woo
authors.initials: JW
authors.lastname: Son
authors.forename: Yun-Mi
authors.initials: YM
authors.lastname: Shin
authors.forename: Un-Sun
authors.initials: US
authors.lastname: Chung
authors.forename: Doug-Hyun
authors.initials: DH
authors.lastname: Han
mesh_terms: D044466:Asian People / Q000235:genetics; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000235:genetics*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000627:therapeutic use; D004644:Emotions / Q000187:drug effects*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage* / Q000627:therapeutic use; D020933:Neurotrophin 3 / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D000697:Central Nervous System Stimulants; D003692:Delayed-Action Preparations; D020933:Neurotrophin 3; D008774:Methylphenidate
keywords: Attention-deficit/hyperactivity disorder; emotional side effect; neurotrophin 3