title: Left ventricular stiffening as therapeutic target for heart failure with preserved ejection fraction.
abstract: The high prevalence of patients with heart failure (HF) with preserved ejection fraction (HFpEF) has highlighted the pivotal role of diastolic function in the development of HF. Abnormalities of diastolic function induce elevated left ventricular (LV) end-diastolic pressure, which leads to pulmonary edema and the symptoms of HF because the LV, left atrium and the pulmonary veins form 1 chamber while the mitral valve is opening. Thus, LV diastolic dysfunction results in the development of HF, in particular, HFpEF. LV stiffness mainly contributes to the transition to HFpEF, but noninvasive assessment and the therapeutic strategy for LV stiffness have not been fully established. This review will focus on the contribution of LV passive stiffness to the development of HFpEF and on the evaluation and treatment of LV stiffening based on insights gained from a hypertensive HFpEF animal model we have developed.
authors.affiliation: Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan. yasushisk@cardiology.med.osaka-u.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sakata
authors.forename: Tomohito
authors.initials: T
authors.lastname: Ohtani
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Takeda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Mano
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003971:Diastole; D004195:Disease Models, Animal; D006325:Heart Atria / Q000473:pathology / Q000503:physiopathology; D006333:Heart Failure / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D008297:Male; D015995:Prevalence; D011654:Pulmonary Edema / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011667:Pulmonary Veins / Q000473:pathology / Q000503:physiopathology; D013318:Stroke Volume