title: Diffuse follicular variant of papillary thyroid carcinoma in a 69-year-old man with extensive extrathyroidal extension: a case report.
abstract: Diffuse follicular variant papillary thyroid carcinoma (DFVPTC) is a rare variant papillary thyroid carcinoma. DFVPTC typically occurs in young females, extensively involves one lobe or both lobes entirely with frequent nodal metastasis and vascular invasion. In contrast to the other subtypes of follicular variant, DFVPTC has biologically aggressive behavior. We present a case of DFVPTC arising in a 69-yr-old male patient. He presented hoarseness for a few months. Following diagnosis of malignancy on aspiration cytology, total thyroidectomy with neck dissection was performed. The tumor involved both lobes of thyroid, encroaching the surrounding structures including tracheal cartilage and esophagus. Multiple lymph node metastasis and vascular invasion were also found. The patient passed away due to the unexplained bleeding of surgical site.
authors.affiliation: Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Yoon Jin
authors.initials: YJ
authors.lastname: Cha
authors.forename: Hang-Seok
authors.initials: HS
authors.lastname: Chang
authors.forename: Soon Won
authors.initials: SW
authors.lastname: Hong
mesh_terms: D000368:Aged; D019002:CD56 Antigen / Q000378:metabolism; D018265:Carcinoma, Papillary, Follicular / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D037502:Galectin 3 / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D053539:Keratin-19 / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed
chemical_list: D019002:CD56 Antigen; D037502:Galectin 3; D053539:Keratin-19
keywords: Metastasis; Papillary Carcinoma; Thyroid Neoplasm