title: Effects of trimetazidine in acute pancreatitis induced by L-arginine.
abstract: BACKGROUND
  In acute pancreatitis, oxygen free radicals (OFRs) and cytokines have been shown to play a role in the failure of pancreatic microcirculation and the development of local tissue damage. We studied the effects of trimetazidine (TMZ), a potent antioxidant and anti-ischemic agent, on acute pancreatitis.
  
  
  METHODS
  Rats were randomized into 3 groups: a control group (n = 15), a study group (n = 15) in which acute pancreatitis was induced with with L-arginine, and a treatment group (n = 15) in which pancreatitis was induced and treated with TMZ intraperitoneally. The rats were followed for 24 hours. At the 24th hour we determined serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), amylase, lactate dehydrogenase (LDH), interleukin 1-Î² (IL-1Î²), interleukin 6 (IL-6) and tumour necrosis factor-Î± (TNF-Î±), and the pancreatic tissues were analyzed histopathologically.
  
  
  RESULTS
  The AST (p < 0.001), ALT (p < 0.01), amylase (p < 0.001), LDH (p < 0.01), TNF-α (p < 0.01), IL-1β (p < 0.001) and IL-6 (p < 0.001) levels, and pancreatic tissue edema (p < 0.01), hemorrhage (p < 0.05), acinar cell necrosis (p < 0.001) and level of perivascular inflammation (p < 0.01), were significantly lower in the treatment group than the study group.
  
  
  CONCLUSIONS
  Trimetazidine markedly decreases biochemical and histopathologic changes during the early stages of acute pancreatitis, thus preserving the pancreas histologically.
authors.affiliation: The Department of General Surgery, Karakocan City Hospital, Elazig, Turkey.
authors.forename: Akan
authors.initials: A
authors.lastname: Yenicerioglu
authors.forename: Ziya
authors.initials: Z
authors.lastname: Cetinkaya
authors.forename: Mustafa
authors.initials: M
authors.lastname: Girgin
authors.forename: Bilal
authors.initials: B
authors.lastname: Ustundag
authors.forename: Ibrahim H
authors.initials: IH
authors.lastname: Ozercan
authors.forename: Refik
authors.initials: R
authors.lastname: Ayten
authors.forename: Burhan H
authors.initials: BH
authors.lastname: Kanat
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000681:Amylases / Q000378:metabolism; D000818:Animals; D001120:Arginine; D001219:Aspartate Aminotransferases / Q000378:metabolism; D004195:Disease Models, Animal; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D010195:Pancreatitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D001120:Arginine; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000681:Amylases; D014292:Trimetazidine