title: [Role of chemokine receptor 2 in renal damage induced by deoxycorticosterone acetate-salt hypertension].
abstract: OBJECTIVE
  To determine the role of chemokine receptor 2 (CCR2) in the development of salt-sensitive hypertension-induced renal damage.
  
  
  METHODS
  We investigated the renal damage induced by uninephrectomy and deoxycorticosterone acetate (DOCA)-salt in mice treated with or without a selective CCR2 antagonist RS504393 for 4 weeks. Sham mice underwent uninephrectomy without receiving DOCA and saline. Systolic blood pressure, urinary excretion of albumin and 8-isoprostane, creatinine clearance, glomerulosclerosis, renal tubulointerstitial injury, and renal monocyte/macrophage infiltration were measured.
  
  
  RESULTS
  DOCA-salt treatment led to increased systolic blood pressure, increased urinary excretion of albumin and 8-isoprostane, decreased creatinine clearance, glomerulosclerosis, renal tubulointerstitial injury, and renal monocyte/macrophage infiltration compared with the sham mice (P<0.05). All of them were prevented by CCR2 inhibition (P<0.05).
  
  
  CONCLUSIONS
  Blockade of CCR2 prevents renal damage induced by DOCA-salt treatment, suggesting that CCR2-mediated monocyte/macrophage infiltration may contribute to salt-sensitive hypertension-induced renal injury.
authors.affiliation: Division of Cardiology, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Sun
authors.forename: Lin
authors.initials: L
authors.lastname: Cui
authors.forename: Wei-hong
authors.initials: WH
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Si
authors.initials: S
authors.lastname: Shen
authors.forename: Ming-jun
authors.initials: MJ
authors.lastname: Zhu
authors.forename: You-ping
authors.initials: YP
authors.lastname: Wang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D054390:Receptors, CCR2 / Q000378:metabolism*; D017673:Sodium Chloride, Dietary / Q000633:toxicity
chemical_list: C515335:Ccr2 protein, mouse; D054390:Receptors, CCR2; D017673:Sodium Chloride, Dietary