title: General and regulatory proteolysis in Bacillus subtilis.
abstract: The soil-dwelling bacterium Bacillus subtilis is widely used as a model organism to study the Gram-positive branch of Bacteria. A variety of different developmental pathways, such as endospore formation, genetic competence, motility, swarming and biofilm formation, have been studied in this organism. These processes are intricately connected and regulated by networks containing e.g. alternative sigma factors, two-component systems and other regulators. Importantly, in some of these regulatory networks the activity of important regulatory factors is controlled by proteases. Furthermore, together with chaperones, the same proteases constitute the cellular protein quality control (PQC) network, which plays a crucial role in protein homeostasis and stress tolerance of this organism. In this review, we will present the current knowledge on regulatory and general proteolysis in B. subtilis and discuss its involvement in developmental pathways and cellular stress management.
authors.affiliation: Institut für Mikrobiologie, Leibniz Universität Hannover, Schneiderberg 50, 30167, Hannover, Germany, moliere@ifmb.uni-hannover.de.
authors.forename: Noël
authors.initials: N
authors.lastname: Molière
authors.forename: Kürşad
authors.initials: K
authors.lastname: Turgay
mesh_terms: D001412:Bacillus subtilis / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D018832:Molecular Chaperones / Q000378:metabolism*; D059748:Proteolysis; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D001426:Bacterial Proteins; D018832:Molecular Chaperones