title: A 3-day randomized clinical trial to investigate the desensitizing properties of three dentifrices.
abstract: BACKGROUND
  The aim of the present study is to evaluate the relative abilities of three desensitizing dentifrices to provide rapid relief of dentin hypersensitivity (DH).
  
  
  METHODS
  Using a double-mask, randomized design, three dentifrices: 1) containing 8% arginine and 1,450 ppm sodium monofluorophosphate; 2) containing 8% strontium acetate and 1,040 ppm sodium fluoride; and 3) containing 30% microaggregation of zinc-carbonate hydroxyapatite nanocrystals were compared after 3-day treatment. Participant's DH was evaluated at baseline and after 3 days using air-blast, tactile, cold water, and subjective tests.
  
  
  RESULTS
  The final sample consisted of 85 individuals: 29 received the arginine-based dentifrice (group 1), 27 the strontium acetate-based dentifrice (group 2), and 29 the dentifrice based on zinc-carbonate hydroxyapatite (group 3). All dentifrices were mostly effective to reduce DH: the percentage of score reduction from baseline to 3 days was >30% for all tests (except for subjective test of group 2). The comparison among the three dentifrices showed that, after 3 days, there was an improvement in air-blast (mean percentage of reduction, 39.2% in group 1, 42.0% in group 2, and 39.2% in group 3), cold water (41.5%, 51.8%, and 50%), tactile (50.3%, 40.1%, and 33.8%), and subjective (33.1%, 17.4%, and 31.4%) test scores, with differences being significant for cold water and subjective tests. For air-blast and tactile tests, there were no significant differences across groups at 3 days. Moreover, no significant differences at any test were observed in a subset of patients that were followed up to 8 weeks: all dentifrices were all highly efficacious.
  
  
  CONCLUSIONS
  This study documents that the three tested dentifrices significantly reduced DH after 3-day treatment, supporting their use in clinical practice. To the best of the authors' knowledge, this is the first report documenting the rapid relief from DH of a zinc-carbonate hydroxyapatite dentifrice.
authors.affiliation: Department of Clinical Sciences and Stomatology, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Orsini
authors.forename: Maurizio
authors.initials: M
authors.lastname: Procaccini
authors.forename: Lamberto
authors.initials: L
authors.lastname: Manzoli
authors.forename: Scilla
authors.initials: S
authors.lastname: Sparabombe
authors.forename: Paolo
authors.initials: P
authors.lastname: Tiriduzzi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Bambini
authors.forename: Angelo
authors.initials: A
authors.lastname: Putignano
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D000388:Air; D001120:Arginine / Q000627:therapeutic use; D002119:Calcium Carbonate / Q000627:therapeutic use; D002254:Carbonates / Q000627:therapeutic use; D003080:Cold Temperature; D003802:Dentifrices / Q000627:therapeutic use*; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D017886:Durapatite / Q000627:therapeutic use; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D005500:Follow-Up Studies; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D053758:Nanoparticles / Q000737:chemistry; D010147:Pain Measurement; D010710:Phosphates / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D013324:Strontium / Q000627:therapeutic use; D014110:Touch; D016896:Treatment Outcome; D014867:Water; D055815:Young Adult; D017967:Zinc Compounds / Q000627:therapeutic use
chemical_list: D000085:Acetates; D002254:Carbonates; D003802:Dentifrices; D057133:Dentin Desensitizing Agents; D010710:Phosphates; D017967:Zinc Compounds; C585805:pro-argin; D014867:Water; C106741:strontium acetate; D012969:Sodium Fluoride; D017886:Durapatite; D001120:Arginine; C036650:zinc carbonate; D002119:Calcium Carbonate; D005459:Fluorides; D013324:Strontium