title: A pilot trial of autologous bone marrow mononuclear cell transplantation through grafting artery: a sub-study focused on segmental left ventricular function recovery and scar reduction.
abstract: BACKGROUND
  Our preliminary study suggested that patients with chronic myocardial infarction (MI) and heart failure could potentially benefit from CABG combined with aBM-MNC by improving global left ventricular (LV) function. The purpose of this sub-study was to quantitatively evaluate the effectiveness of aBM-MNC transplantation during CABG in patients with chronic MI by intensively analyzing the global and segmental LV function, the scar, and the relationships between the function recovery and the scar transmural extent.
  
  
  METHODS
  A randomized, double-blinded, placebo-controlled study was performed in 50 patients with chronic MI. The patients were randomly allocated into CABG with stem cell transplantation (group A) and CABG only (group B) groups. CMR assessments of global and segmental left ventricular function and scar tissue were performed before surgery and repeated at 12 months after CABG and aBM-MNC transplantation.
  
  
  RESULTS
  The left ventricular ejection fraction (LVEF) improved by 13.5% and 8.0% in group A and B respectively (P=0.04). Segmental analysis of regional LV function recovery indicated that more improvement in contractility was found in group A within the same degree of the infarct transmurality (P=0.017) and showed a predominant interaction in the most severely affected segments (76-100%, P=0.016). Decrease in infarct size between the two groups did not reach statistical difference (9.4% vs. 6.0%, P=0.100).
  
  
  CONCLUSIONS
  CMR assessments revealed reversed ventricular remodeling and improved systolic function and scar reduction in patients who underwent aBM-MNC transplantation during CABG. And the conjunctional use of CABG and stem cell therapy could improve the left ventricular function in patients with chronic MI.
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China.
authors.forename: Minjie
authors.initials: M
authors.lastname: Lu
authors.forename: Sheng
authors.initials: S
authors.lastname: Liu
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zheng
authors.forename: Gang
authors.initials: G
authors.lastname: Yin
authors.forename: Lei
authors.initials: L
authors.lastname: Song
authors.forename: Huaibing
authors.initials: H
authors.lastname: Chen
authors.forename: Xiuyu
authors.initials: X
authors.lastname: Chen
authors.forename: Qiyin
authors.initials: Q
authors.lastname: Chen
authors.forename: Shiliang
authors.initials: S
authors.lastname: Jiang
authors.forename: Liangxin
authors.initials: L
authors.lastname: Tian
authors.forename: Zuoxiang
authors.initials: Z
authors.lastname: He
authors.forename: Shengshou
authors.initials: S
authors.lastname: Hu
authors.forename: Shihua
authors.initials: S
authors.lastname: Zhao
mesh_terms: D016026:Bone Marrow Transplantation / Q000379:methods*; D002921:Cicatrix / Q000209:etiology / Q000517:prevention & control; D001026:Coronary Artery Bypass / Q000379:methods*; D003331:Coronary Vessels; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D010865:Pilot Projects; D013318:Stroke Volume; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Cardiac magnetic resonance; Chronic myocardial infarction; Coronary artery bypass grafting; Mesenchymal stem cells