title: Reaction of the rat tissues to implantation of polyhydroxyalkanoate films and ultrafine fibers.
abstract: The reaction of various tissues of rats to implantation of polyhydroxyalkanoate films and ultrafine fibers was studied by optic microscopy. Implantation of polyhydroxyalkanoate films into the abdominal cavity caused a peritoneal reaction, leading after 1 month to the formation of fibrous adhesions between polyhydroxyalkanoate and intestinal loops. Under the skin and in the muscle tissue polyhydroxyalkanoate films were encapsulated in a thick fibrous capsule. Implantation of polyhydroxyalkanoate ultrathin fibers led to formation of foreign body granulomas in all tissues with perifocal inflammation and sclerosis of the adjacent tissues. The polymer was fragmented in these granulomas and phagocytosed by macrophages with the formation of giant foreign body cells. Hence, polyhydroxyalkanoate materials implanted in vivo caused chronic granulomatous inflammatory reaction and were very slowly destroyed by macrophages.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. imai@mail.ru
authors.forename: I V
authors.initials: IV
authors.lastname: Maiborodin
authors.forename: A I
authors.initials: AI
authors.lastname: Shevela
authors.forename: V V
authors.initials: VV
authors.lastname: Morozov
authors.forename: Ya V
authors.initials: YV
authors.lastname: Novikova
authors.forename: V A
authors.initials: VA
authors.lastname: Matveeva
authors.forename: M N
authors.initials: MN
authors.lastname: Drovosekov
authors.forename: M I
authors.initials: MI
authors.lastname: Barannik
mesh_terms: D034841:Abdominal Cavity; D000818:Animals; D005547:Foreign Bodies / Q000276:immunology*; D005549:Foreign-Body Reaction / Q000276:immunology* / Q000473:pathology; D006099:Granuloma / Q000139:chemically induced / Q000276:immunology; D015745:Granuloma, Foreign-Body / Q000276:immunology*; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D008853:Microscopy; D010537:Peritoneum / Q000187:drug effects / Q000276:immunology*; D054813:Polyhydroxyalkanoates / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012598:Sclerosis / Q000139:chemically induced / Q000276:immunology; D000267:Tissue Adhesions / Q000139:chemically induced / Q000276:immunology
chemical_list: D054813:Polyhydroxyalkanoates