title: Rapidly progressive post-transplant lymphoproliferative disease following withdrawal of sirolimus.
abstract: Sirolimus, a potent inhibitor of B- and T-cell activation. is a commonly used immunosuppressant after renal transplantation. Withdrawal of sirolimus from the immunosuppression regimen may reduce B-cell surveillance. We present a case of rapidly progressive central nervous system (CNS) polymorphic Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disorder following the withdrawal of sirolimus.
authors.affiliation: Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa. marc.mendelson@uct.ac.za
authors.forename: Marc
authors.initials: M
authors.lastname: Mendelson
authors.forename: Zunaid
authors.initials: Z
authors.lastname: Barday
authors.forename: Roland
authors.initials: R
authors.lastname: Eastman
authors.forename: David
authors.initials: D
authors.lastname: Le Feuvre
authors.forename: Sally
authors.initials: S
authors.lastname: Candy
authors.forename: Hue-Tsi
authors.initials: HT
authors.lastname: Wu
authors.forename: Charles
authors.initials: C
authors.lastname: Swanepoel
mesh_terms: D000328:Adult; D001706:Biopsy; D018450:Disease Progression; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D011183:Postoperative Complications; D020123:Sirolimus / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus