title: Resolvin D1 and its GPCRs in resolution circuits of inflammation.
abstract: Endogenous mechanisms that turn off excessive inflammation and prompt its timely resolution are of considerable interest since unresolved inflammation is associated with several widely recurrent diseases. In recent years, previously unrecognized chemical mediators derived from polyunsaturated fatty acids were identified that control the acute inflammatory response by activating local resolution programs. Resolvin (Rv) D1 is an endogenous chemical mediator biosynthesized from the ω-3 docosahexaenoic acid that exerts potent anti-inflammatory and pro-resolving activities in a stereospecific manner by acting on pro-resolving G-protein coupled receptors (GPCRs). Here, I overviewed the biosynthesis and mechanisms of action of RvD1 focusing on the recently reported miRNAs that underscore its bioactions. The elucidation of RvD1-activated mechanisms operating in vivo to keep acute inflammation under physiologic boundaries and stimulate resolution opened many new opportunities in resolution pharmacology to target inflammation-related human pathologies.
authors.affiliation: Department of Clinical and Experimental Sciences, "G.d'Annunzio" University of Chieti and Center of Excellence on Aging (CeSI) "G.d'Annunzio" University Foundation, Chieti, Italy. Electronic address: a.recchiuti@unich.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Recchiuti
mesh_terms: D000818:Animals; D004281:Docosahexaenoic Acids / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism*; D050356:Lipid Metabolism; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D043562:Receptors, G-Protein-Coupled; C518399:resolvin D1; D004281:Docosahexaenoic Acids
keywords: Lipid mediators: Pharmacology; Macrophages; Omega-3 PUFA; Resolution; microRNAs