title: The mammalian clock and chronopharmacology.
abstract: Increases in our understanding of the molecular control of circadian rhythms and subsequent signaling pathways has allowed for new therapeutic drug targets to be identified as well as for a better understanding of how to more efficaciously and safely utilize current drugs. Here, we review recent advances in targeting components of the molecular clock in mammals for the development of novel therapeutics as well as describe the impact of the circadian rhythm on drug efficacy and toxicity.
authors.affiliation: 130 Scripps Way 2A1, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
authors.forename: Kristine
authors.initials: K
authors.lastname: Griffett
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Burris
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D057906:Circadian Clocks / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects; D055870:Drug Chronotherapy; D006801:Humans
chemical_list: D000970:Antineoplastic Agents