title: Imaging advances in asthma.
abstract: BACKGROUND
  Asthma is a global burden, affecting 5% of the general adult population, with approximately 5 - 10% suffering from severe asthma. Severe asthma is a complex heterogeneous disease entity, with high morbidity and mortality. Recent years have seen the introduction of a vast array of new imaging technologies, which have provided the ability to comprehensively, non-invasively and functionally assess the lungs. These advances have resulted in a better understanding of the pathophysiology in severe asthma and have the unprecedented potential to unravel the structure-function relationship of severe asthma in the future.
  
  
  METHODS
  This review article chronologically describes the technological advances currently used and to be used in the future. The article covers pitfalls in imaging of the airways and lung parenchyma in asthma from chest x-rays, CT scans, MRI, confocal florescence endomicroscopy to computational fluid dynamics.
  
  
  CONCLUSIONS
  Novel qualitative and quantitative imaging techniques have enabled us to study the large airway architecture in detail, assess the small airway structure and perform functional or novel physiological evaluations. Despite spectacular advances in imaging techniques and the birth of new modalities, there is an urgent need for both proof-of-concept studies, large cross-sectional and longitudinal clinical trials in severe asthma to validate and clinically correlate imaging-derived measures. This will extend our current understanding of the pathophysiology of severe asthma, and unravel the structure-function relationship, with the potential to discover novel severe asthma phenotypes, predict mortality, morbidity and response to existing and novel pharmacological and non-pharmacological therapies.
authors.affiliation: University of Leicester , Institute for Lung Health, Department of Infection , Inflammation and Immunity, Leicester , UK.
authors.forename: Carolina
authors.initials: C
authors.lastname: Walker
authors.forename: Sumit
authors.initials: S
authors.lastname: Gupta
authors.forename: Vimal
authors.initials: V
authors.lastname: Raj
authors.forename: Salman
authors.initials: S
authors.lastname: Siddiqui
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Brightling