title: [A relationship between analgesic and neurotropic effects by the example of milgamma].
abstract: Combined vitamin preparations containing thiamine (vitamin B1), pyridoxine (vitamin B6), and cyanocobalamin (vitamin B12) are widely used in medical practice. The results of investigations have confirmed that it is expedient to potentiate an analgesic effect due to the concurrent use of vitamin B group and nonsteroidal anti-inflammatory drugs given to relieve significant neuropathic pain. Milgamma compositum (Wörwag Pharma, Germany) is one of the most studied drugs on the Russian market, which contains a combination of vitamin B group (including benfotiamin).
authors.forename: M V
authors.initials: MV
authors.lastname: Zhuravleva
authors.forename: E V
authors.initials: EV
authors.lastname: Shikh
authors.forename: A A
authors.initials: AA
authors.lastname: Makhova
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005947:Glucose / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006031:Glycosylation / Q000187:drug effects*; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D018696:Neuroprotective Agents; D010147:Pain Measurement; D016032:Randomized Controlled Trials as Topic; D013831:Thiamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D017127:Glycation End Products, Advanced; D018696:Neuroprotective Agents; D014803:Vitamin B Complex; D003577:Cytochrome P-450 Enzyme System; D005947:Glucose; D013831:Thiamine; C013835:benphothiamine