title: [A new antiviral drug Triazavirin: results of phase II clinical trial].
abstract: The results of the clinical trial testing the efficacy of a new anti-influenza drug Triazavirin are presented in this work. The data of the trial were gathered during the 2010 influenza season. The treatment with oral Triazavirin significantly reduced the duration of the main clinical symptoms of influenza (intoxication, fever, respiratory symptoms), decreased the incidence of the influenza-related complications and the use of symptomatic drugs. The re-isolation rate of the influenza A and B viruses was significantly lower in the patients who were using Triazavirin. The analysis of the clinical data showed that the optimal prescribed dosage was 250 mg 3 times a day.
authors.forename: O I
authors.initials: OI
authors.lastname: Kiselev
authors.forename: E G
authors.initials: EG
authors.lastname: Deeva
authors.forename: T I
authors.initials: TI
authors.lastname: Mel'nikova
authors.forename: K N
authors.initials: KN
authors.lastname: Kozeletskaia
authors.forename: A S
authors.initials: AS
authors.lastname: Kiselev
authors.forename: V L
authors.initials: VL
authors.lastname: Rusinov
authors.forename: V N
authors.initials: VN
authors.lastname: Charushin
authors.forename: O N
authors.initials: ON
authors.lastname: Chupakhin
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001393:Azoles / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification; D009981:Influenza B virus / Q000302:isolation & purification; D007251:Influenza, Human / Q000188:drug therapy / Q000821:virology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D014227:Triazines / Q000008:administration & dosage* / Q000009:adverse effects; D014230:Triazoles
chemical_list: D000998:Antiviral Agents; D001393:Azoles; D014227:Triazines; D014230:Triazoles; C539416:riamilovir