title: Circulating levels of novel adipocytokines in patients with colorectal cancer.
abstract: OBJECTIVE
  Adipocytokines have been reported to contribute to the pathogenesis of colorectal cancer (CRC). The aim of this matched case-control study was to explore circulating novel adipocytokines, such as serum visfatin, omentin-1 and vaspin levels in patients with CRC.
  
  
  METHODS
  Serum visfatin, omentin-1, and vaspin levels were measured in 69 subjects (39 patients with colorectal cancer and 30 age- and sex-matched healthy controls) using enzyme-linked immunosorbent assay (ELISA) methods.
  
  
  RESULTS
  Compared with the controls, patients with CRC had significantly higher circulating omentin-1 (203.23 vs 9.12 ng/ml, p < 0.0001) visfatin (4.03 vs 2.01 ng/ml, p < 0.0001) and vaspin (0.54 vs 0.31 ng/ml, p = 0.015) levels. After adjustment for covariates (age and body mass index), patients with CRC had significantly higher serum omentin-1 (p < 0.0001), visfatin (p < 0.0001), and vaspin (p = 0.040) levels than the control group. Furthermore, the results did not change when age and waist-to-hip ratio were considered as covariates in the general linear models.
  
  
  CONCLUSIONS
  The observed higher levels of omentin-1, visfatin, and vaspin in patients with CRC, independent of measures of obesity, suggest that these adipocytokines may have a potential role in the development of CRC through mechanisms other than the indirect mechanisms that are active in the association between obesity and CRC.
authors.affiliation: Department of Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran 1419733141, Iran.
authors.forename: Mohammad Sadegh
authors.initials: MS
authors.lastname: Fazeli
authors.forename: Habibollah
authors.initials: H
authors.lastname: Dashti
authors.forename: Samad
authors.initials: S
authors.lastname: Akbarzadeh
authors.forename: Majid
authors.initials: M
authors.lastname: Assadi
authors.forename: Ali
authors.initials: A
authors.lastname: Aminian
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Keramati
authors.forename: Iraj
authors.initials: I
authors.lastname: Nabipour
mesh_terms: D054392:Adipokines / Q000097:blood*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D015843:Serpins / Q000097:blood*
chemical_list: D054392:Adipokines; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; C507339:SERPINA12 protein, human; D015843:Serpins; D054409:Nicotinamide Phosphoribosyltransferase