title: Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond.
abstract: During development and cellular differentiation, tissue- and cell-specific programs mediate mitochondrial biogenesis to meet physiological needs. However, environmental and disease-associated factors can perturb mitochondrial activities, requiring cells to adapt to protect mitochondria and maintain cellular homeostasis. Several mitochondrion-to-nucleus signaling pathways, or retrograde responses, have been described, but the mechanisms by which mitochondrial stress or dysfunction is sensed to coordinate precisely the appropriate response has only recently begun to be understood. Recent studies of the mitochondrial unfolded-protein response (UPRmt) indicate that the cell monitors mitochondrial protein import efficiency as an indicator of mitochondrial function. Here, we review how the cell evaluates mitochondrial function and regulates transcriptional induction of the UPRmt, adapts protein-synthesis rates and activates mitochondrial autophagy to promote mitochondrial function and cell survival during stress.
authors.affiliation: Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. haynesc@mskcc.org
authors.forename: Cole M
authors.initials: CM
authors.lastname: Haynes
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Fiorese
authors.forename: Yi-Fan
authors.initials: YF
authors.lastname: Lin
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism; D008954:Models, Biological; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D056811:Unfolded Protein Response / Q000502:physiology*
chemical_list: D024101:Mitochondrial Proteins; D017382:Reactive Oxygen Species