title: Efficacy of different mouthrinse formulations in reducing oral malodour: a randomized clinical trial.
abstract: OBJECTIVE
  The aim of this study was to assess the efficacy of mouthrinses formulations in oral malodour.
  
  
  METHODS
  This single-centre, double-blind, randomized, parallel group clinical trial compared the efficacy of Halita™ and meridol(®) with and without zinc lactate versus negative and positive control. Volunteers with confirmed oral malodour (18/group) rinsed with one mouthrinse during 7 days (15 ml, 2x/day for 1 min.). 15 min. after a first rinse (masking effect), and after 7 days (therapeutic effect) the change in organoleptic scores and level of sulphur compounds was recorded.
  
  
  RESULTS
  All rinses showed a masking effect (OLS 1 to 2 values reduced), only the rinses with antimicrobial ingredients showed a therapeutic effect (OLS 1 to 1.5 value less). The addition of zinc resulted in a more pronounced masking effect. Halita™ and meridol(®) with zinc showed the best therapeutic effect.
  
  
  CONCLUSIONS
  Although the masking effect of the rinses can be attributed partially to a dilution and the effect of aromas, the therapeutic effect should be linked to the anti-microbial action of active ingredients and counter action of zinc ions on VSC. A complete resolution of the unpleasant breath by additional mechanical intervention remains to be proven.
authors.affiliation: Department of Periodontology, Catholic University Leuven, Leuven, Belgium.
authors.forename: Jesica
authors.initials: J
authors.lastname: Dadamio
authors.forename: Marie
authors.initials: M
authors.lastname: Van Tournout
authors.forename: Wim
authors.initials: W
authors.lastname: Teughels
authors.forename: Christel
authors.initials: C
authors.lastname: Dekeyser
authors.forename: Wim
authors.initials: W
authors.lastname: Coucke
authors.forename: Marc
authors.initials: M
authors.lastname: Quirynen
mesh_terms: D000588:Amines / Q000737:chemistry / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000737:chemistry / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000627:therapeutic use; D058491:Bacterial Load / Q000187:drug effects; D002594:Cetylpyridinium / Q000737:chemistry / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D002849:Chromatography, Gas / Q000295:instrumentation; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006209:Halitosis / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis; D007773:Lactates / Q000737:chemistry / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D016877:Oxidants / Q000737:chemistry / Q000627:therapeutic use; D012463:Saliva / Q000382:microbiology; D013438:Sulfhydryl Compounds / Q000032:analysis; D014002:Tin Fluorides / Q000737:chemistry / Q000627:therapeutic use; D014059:Tongue / Q000382:microbiology; D016896:Treatment Outcome; D055549:Volatile Organic Compounds / Q000032:analysis; D017967:Zinc Compounds / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000588:Amines; D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D007773:Lactates; D009067:Mouthwashes; D016877:Oxidants; D013438:Sulfhydryl Compounds; D014002:Tin Fluorides; D055549:Volatile Organic Compounds; D017967:Zinc Compounds; C059813:Meridol; C005231:methylmercaptan; D002594:Cetylpyridinium; C010882:chlorhexidine gluconate; D002710:Chlorhexidine; D006862:Hydrogen Sulfide