title: Pharmacokinetic study of hydroxypropylmethylcellulose microparticles loaded with cimetidine.
abstract: OBJECTIVE
  The objective of this study was to assess the pharmacokinetic behavior of floating hydroxypropylmethylcellulose microparticles loaded with cimetidine (FMC) prepared using the non-solvent addition coacervation technique.
  
  
  METHODS
  Based on the physico-chemical characteristics of three formulations (FMC1, FMC2 and FMC3), FMC2 having a 1:3 ratio of cimetidine:HPMC was found optimum. For in vivo analysis, a new HPLC analytical method was developed and validated. The optimized formulations were subjected to in vivo studies to calculate the various pharmacokinetic parameters for developed optimized microparticulate formulation FMC3. The developed floating microparticles of cimetidine were further evaluated by in vivo experimentation.
  
  
  RESULTS
  The bioavailability parameters were found as: Cmax 1508.79 ± 37.95 ng/ml, Tmax 3.67 ± 0.17 h and AUC 14366.19 ± 377.64 ng h /mL.
  
  
  CONCLUSIONS
  For prolonged drug release in the stomach, developed floating microparticles of cimetidine (FMC3) may be used, thereby improving the bioavailability and patient compliance.
authors.affiliation: Faculty of Pharmacy & Alternative Medicine, the Islamia University of Bahawalpur, Punjab, Pakistan.
authors.forename: Rozina
authors.initials: R
authors.lastname: Kousar
authors.forename: Mahmood
authors.initials: M
authors.lastname: Ahmad
authors.forename: Ghulam
authors.initials: G
authors.lastname: Murtaza
authors.forename: Shujaat A
authors.initials: SA
authors.lastname: Khan
authors.forename: Sabiha
authors.initials: S
authors.lastname: Karim
authors.forename: Izhar
authors.initials: I
authors.lastname: Hussain
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D002927:Cimetidine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D065347:Hypromellose Derivatives; D008297:Male; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008863:Microspheres; D012015:Reference Standards; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D065347:Hypromellose Derivatives; D002927:Cimetidine; D008747:Methylcellulose