title: Volatiles, a glutarimide alkaloid and antimicrobial effects of Croton pullei (Euphorbiaceae).
abstract: Chemical investigation of Croton pullei (Euphorbiaceae) collected in the Brazilian Amazon region was revisited. The chemical composition of the essential oils of leaves and stems was analyzed by GC/MS. It was found that both the oils comprise mainly terpenes, among which linalool was the major one (24.90 and 39.72%, respectively). Phytochemical investigation of the stem methanol extract led to the isolation of a new natural product from the glutarimide alkaloid group named N-[2,6-dioxo-1-(2-phenylethyl)-3-piperidinyl]-acetamide, confirming that C. pullei is a rich source of this class of alkaloids. The hexane and methanol extracts of the stems of C. pullei showed moderate antibacterial and antifungal activity and the highest inhibition was observed when the methanol extract was tested against Staphylococcus aureus CCMB 262 and CCMB 263.
authors.affiliation: Programa de Pós-graduação em Química, Universidade Federal do Pará, Av. Augusto Corrêa 01, 66075-110, Belém-PA, Brazil. rosana.nsp@gmail.com
authors.forename: Rosana N S
authors.initials: RN
authors.lastname: Peixoto
authors.forename: Giselle M S P
authors.initials: GM
authors.lastname: Guilhon
authors.forename: Maria
authors.initials: M
authors.lastname: das Graças B Zoghbi
authors.forename: Isabella S
authors.initials: IS
authors.lastname: Araújo
authors.forename: Ana Paula T
authors.initials: AP
authors.lastname: Uetanabaro
authors.forename: Lourivaldo S
authors.initials: LS
authors.lastname: Santos
authors.forename: Davi
authors.initials: D
authors.lastname: do S B Brasil
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D029802:Croton / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D010881:Piperidones / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D055549:Volatile Organic Compounds / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D010881:Piperidones; D010936:Plant Extracts; D055549:Volatile Organic Compounds; C007864:glutarimide