title: Highly sensitive glucose sensor based on pt nanoparticle/polyaniline hydrogel heterostructures.
abstract: Glucose enzyme biosensors have been shown useful for a range of applications from medical diagnosis, bioprocess monitoring, to beverage industry and environmental monitoring. We present here a highly sensitive glucose enzyme sensor based on Pt nanoparticles (PtNPs)-polyaniline (PAni) hydrogel heterostructures. High-density PtNPs were homogeneously loaded onto the three-dimensional (3D) nanostructured matrix of the PAni hydrogel. The PtNP/PAni hydrogel heterostructure-based glucose sensor synergizes the advantages of both the conducting hydrogel and the nanoparticle catalyst. The porous structure of the PAni hydrogel favored the high density immobilization of the enzyme and the penetration of water-soluble molecules, which helped efficiently catalyze the oxidation of glucose. In addition, the PtNPs catalyzed the decomposition of hydrogen peroxide that was generated during the enzymatic reaction. The transferred charges from these electrochemical processes were efficiently collected by the highly conducting PtNP/PAni hydrogel heterostructures. The glucose enzyme sensor based on this heterostructure exhibited unprecedented sensitivity, as high as 96.1 μA·mM(-1)·cm(-2), with a response time as fast as 3 s, a linear range of 0.01 to 8 mM, and a low detection limit of 0.7 μM.
authors.affiliation: School of Electronic Science and Engineering, National Laboratory of Microstructures, Nanjing, Nanjing University, Nanjing 210093, China.
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Zhai
authors.forename: Borui
authors.initials: B
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.forename: Lijia
authors.initials: L
authors.lastname: Pan
authors.forename: Yaqun
authors.initials: Y
authors.lastname: Wang
authors.forename: Wenbo
authors.initials: W
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Guihua
authors.initials: G
authors.lastname: Yu
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D005949:Glucose Oxidase / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry; D008839:Microelectrodes; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010984:Platinum / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D020100:Hydrogels; C416807:polyaniline; D010984:Platinum; D005949:Glucose Oxidase; D005947:Glucose