title: Association between polymorphisms in genes encoding methylenetetrahydrofolate reductase and the risk of Ménière's disease.
abstract: Folate metabolism is essential for cellular functioning. Despite extensive research on the roles of folate-metabolism-related gene polymorphisms in the pathophysiology of many diseases, such as cardiovascular disease, cancers, and sudden sensorineural hearing loss, little is known about their association with Ménière's disease (MD). The aim of this study was to investigate the effect of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms (C677T and A1298C) on the risk of MD in a Japanese population. We examined the C677T and A1298C (rs1801133 and rs1801131) polymorphisms in the MTHFR gene and compared them between 1946 adults (986 men and 960 women) participating in the National Institute for Longevity Sciences Longitudinal Study of Aging and 86 cases of MD. A multiple logistic regression was performed to obtain odds ratios (ORs) for the risk of MD regarding the MTHFR polymorphisms before (model 1) and after (model 2) adjustment for age and sex factors. The OR of MTHFR C677T for the risk of MD was 0.669 (95% confidence interval [CI], 0.479-0.934) in model 1 and 0.680 (95% CI, 0.484-0.954) in model 2. In contrast, the OR of MTHFR A1298C for the risk of MD was 1.503 (95% CI, 1.064-2.123) in model 1 and 1.505 (95% CI, 1.045-2.167) in model 2. Our results imply that the MTHFR C677T and A1298C polymorphisms are associated with the risk of MD.
authors.affiliation: Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Yang
authors.initials: Y
authors.lastname: Huang
authors.forename: Masaaki
authors.initials: M
authors.lastname: Teranishi
authors.forename: Yasue
authors.initials: Y
authors.lastname: Uchida
authors.forename: Naoki
authors.initials: N
authors.lastname: Nishio
authors.forename: Ken
authors.initials: K
authors.lastname: Kato
authors.forename: Hironao
authors.initials: H
authors.lastname: Otake
authors.forename: Tadao
authors.initials: T
authors.lastname: Yoshida
authors.forename: Michihiko
authors.initials: M
authors.lastname: Sone
authors.forename: Saiko
authors.initials: S
authors.lastname: Sugiura
authors.forename: Fujiko
authors.initials: F
authors.lastname: Ando
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimokata
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D005260:Female; D005804:Genes, Lethal; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008575:Meniere Disease / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011571:Psychoacoustics; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)