title: Effects of nonstarch polysaccharides with different molecular weights on the development of Lewis lung carcinoma in mice and efficiency of cytostatic therapy.
abstract: The effects of nonstarch polysaccharides with different molecular weights on the development of Lewis' lung carcinoma and efficiency of cyclophosphamide therapy in mice were studied. Treatment with these substances with low molecular weights (<30 kDa) caused no changes in the primary tumor growth, but inhibited its metastasizing, while nonstarch polysaccharides with high molecular weights (>400 kDa) inhibited the growth of Lewis' lung carcinoma node. Antimetastatic effects of cyclophosphamide were stimulated by low and high molecular weight polysaccharides.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. zep0929@mail.ru
authors.forename: O Yu
authors.initials: OY
authors.lastname: Rybalkina
authors.forename: T G
authors.initials: TG
authors.lastname: Razina
authors.forename: K A
authors.initials: KA
authors.lastname: Lopatina
authors.forename: E N
authors.initials: EN
authors.lastname: Amosova
authors.forename: S G
authors.initials: SG
authors.lastname: Krylova
authors.forename: L A
authors.initials: LA
authors.lastname: Efimova
authors.forename: E A
authors.initials: EA
authors.lastname: Safonova
authors.forename: E P
authors.initials: EP
authors.lastname: Zueva
authors.forename: M Yu
authors.initials: MY
authors.lastname: Khotimchenko
authors.forename: Yu S
authors.initials: YS
authors.lastname: Khotimchenko
mesh_terms: D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D011134:Polysaccharides / Q000627:therapeutic use*
chemical_list: D011134:Polysaccharides; D003520:Cyclophosphamide