title: Bioreactor design considerations for hollow organs.
abstract: There are many important considerations in the design, construction, and use of a bioreactor for growing hollow organs such as vessels, gastrointestinal tissue, esophagus, and others. The growth of new organs requires a specialized container that provides sterility and an environment conducive to cell-seeding and attachment onto a three-dimensional bioabsorbable porous scaffold, incubation, maturation, and shipping for implantation. The materials' selection, dimensions, manufacturing, testing, and use of the bioreactor are all factors that should be considered in designing a bioreactor for the development of hollow organs.
authors.affiliation: Tengion Inc., Winston-Salem, NC, USA.
authors.forename: Jeff
authors.initials: J
authors.lastname: Fish
authors.forename: Craig
authors.initials: C
authors.lastname: Halberstadt
authors.forename: Darell W
authors.initials: DW
authors.lastname: McCoy
authors.forename: Neil
authors.initials: N
authors.lastname: Robbins
mesh_terms: D019149:Bioreactors; D006801:Humans; D009924:Organ Culture Techniques / Q000295:instrumentation* / Q000379:methods*; D038081:Organogenesis / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014551:Urinary Tract / Q000166:cytology*