title: Cubic phase nanoparticles for sustained release of ibuprofen: formulation, characterization, and enhanced bioavailability study.
abstract: In order to improve the oral bioavailability of ibuprofen, ibuprofen-loaded cubic nanoparticles were prepared as a delivery system for aqueous formulations. The cubic inner structure was verified by cryogenic transmission electron microscopy. With an encapsulation efficiency greater than 85%, the ibuprofen-loaded cubic nanoparticles had a narrow size distribution around a mean size of 238 nm. Differential scanning calorimetry and X-ray diffraction determined that ibuprofen was in an amorphous and molecular form within the lipid matrix. The in vitro release of ibuprofen from cubic nanoparticles was greater than 80% at 24 hours, showing sustained characteristics. The pharmacokinetic study in beagle dogs showed improved absorption of ibuprofen from cubic nanoparticles compared to that of pure ibuprofen, with evidence of a longer half-life and a relative oral bioavailability of 222% (P < 0.05). The ibuprofen-loaded cubic nanoparticles provide a promising carrier candidate with an efficient drug delivery for therapeutic treatment.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, People's Republic of China.
authors.forename: Linghui
authors.initials: L
authors.lastname: Dian
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Zhouhua
authors.initials: Z
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Pan
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Peng
authors.forename: Xintian
authors.initials: X
authors.lastname: Huang
authors.forename: Zhefei
authors.initials: Z
authors.lastname: Guo
authors.forename: Guilan
authors.initials: G
authors.lastname: Quan
authors.forename: Xuan
authors.initials: X
authors.lastname: Shi
authors.forename: Bao
authors.initials: B
authors.lastname: Chen
authors.forename: Ge
authors.initials: G
authors.lastname: Li
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Wu
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004285:Dogs; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D005260:Female; D007052:Ibuprofen / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007052:Ibuprofen
keywords: bioavailability; cubic nanoparticles; ibuprofen; oral drug delivery