title: Non-adherence in type 2 diabetes: practical considerations for interpreting the literature.
abstract: The rising prevalence of type 2 diabetes poses a serious threat to human health and the viability of many health care systems around the world. Although several prescription medications can play a vital role in controlling symptoms and preventing complications, non-adherence to these therapies is highly prevalent and has been linked to increases in morbidity, mortality, and health care costs. Although a vast array of significant adherence predictors has been identified, the ability to explain or predict non-adherence with known risk-factors remains poor. Further, the definitions, outcomes, and various measures used in the non-adherence literature can be misleading for the unfamiliar reviewer. In this narrative review, a practical overview of important considerations for interpreting adherence endpoints and measures is discussed. Also, an organizational framework is proposed to consider published adherence interventions. This framework may allow for a unique appreciation into areas of limited knowledge and thus highlights targets for future research.
authors.affiliation: College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan.
authors.forename: David F
authors.initials: DF
authors.lastname: Blackburn
authors.forename: Jaris
authors.initials: J
authors.lastname: Swidrovich
authors.forename: Mark
authors.initials: M
authors.lastname: Lemstra
keywords: adherence interventions; compliance; medication adherence; type 2 diabetes