title: Cumulative risk of cancer detection in breast cancer screening by protocol strategy.
abstract: BACKGROUND
  There is little information on the individual risk of screen-detected cancer in women over successive participations. This study aimed to estimate the 10-year cumulative breast cancer detection risk (ductal carcinoma in situ and invasive carcinoma) in a population-based breast cancer screening program according to distinct protocol strategies. A further aim was to determine which strategies maximized the cancer detection risk and how this risk was affected by the radiologic protocol variables.
  
  
  METHODS
  Data were drawn from a retrospective cohort of women from nine population-based screening programs in Spain from 1990 to 2006. We used logistic regression with discrete intervals to estimate the cumulative detection risk at 10 years of follow-up according to radiologic variables and protocol strategies.
  
  
  RESULTS
  In women starting screening at the age of 45-59 years, the cumulative risk of screen-detected cancer at 10 years ranged from 11.11 to 16.71 per 1,000 participants according to the protocol strategy. The cumulative detection risk for overall cancer and invasive cancer was the highest with strategies using digital mammography, double reading, and two projections (16.71 and 12.07 ‰, respectively). For ductal carcinoma in situ, cumulative detection risk was the highest with strategies using screen-film, double reading, and two projections (2.32 ‰). The risk was the lowest with strategies using screen-film mammography, single reading, and two projections.
  
  
  CONCLUSIONS
  This study found that at least eleven cancers are detected per 1,000 women screened in the first 10 years of follow-up. Enhanced knowledge of the variability in cumulative risk of screen-detected cancer could improve protocol strategies.
authors.affiliation: Epidemiology and Evaluation Department, Hospital del Mar-IMIM, Passeig Marítim, 25-29, 08003 Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Blanch
authors.forename: M
authors.initials: M
authors.lastname: Sala
authors.forename: M
authors.initials: M
authors.lastname: Román
authors.forename: M
authors.initials: M
authors.lastname: Ederra
authors.forename: D
authors.initials: D
authors.lastname: Salas
authors.forename: R
authors.initials: R
authors.lastname: Zubizarreta
authors.forename: M
authors.initials: M
authors.lastname: Sanchez
authors.forename: M
authors.initials: M
authors.lastname: Rué
authors.forename: X
authors.initials: X
authors.lastname: Castells
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis* / Q000453:epidemiology; D015331:Cohort Studies; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D016015:Logistic Models; D008327:Mammography / Q000379:methods*; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D015233:Models, Statistical; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology