title: A positive effect of immune suppression on corrected count increment after platelet transfusion at 1 but not at 24h.
abstract: The effects of patient characteristics on corrected count increment (CCI) in hemato-oncology patients were studied. CCI values were 13.6 ± 6.5 (1h, n=79) and 6.3 ± 5.3 (24h, n=69). With concomitant immune suppression CCI was higher at 1h (20.0 ± 7.9 versus 13.2 ± 6.3, p=0.023), but not at 24h (5.9 ± 6.7 versus 6.3 ± 5.2; p=0.88). The observed effect is short lived, potentially benefiting bleeding patients, but may not increase intervals between transfusions. Further, CCI1h was lower if fever was present (9.7 ± 3.6 versus 14.3 ± 6.7; p=0.002), and corresponding CCI24h values were 3.7 ± 6.3 versus 6.7 ± 5.0 (p=0.09). At 24h an effect for previous transfusions was observed, 6.7 ± 5.1 (with) versus 1.6 ± 5.4 (without p=0.02).
authors.affiliation: Sanquin Blood Supply, P.O. Box 1191, 9701 BD Groningen, The Netherlands. Electronic address: m.dijkstra@sanquin.nl.
authors.forename: M J
authors.initials: MJ
authors.lastname: Dijkstra-Tiekstra
authors.forename: J M M
authors.initials: JM
authors.lastname: Rondeel
authors.forename: J
authors.initials: J
authors.lastname: Slomp
authors.forename: W M
authors.initials: WM
authors.lastname: Smid
authors.forename: J
authors.initials: J
authors.lastname: de Wildt-Eggen
mesh_terms: D005260:Female; D019337:Hematologic Neoplasms / Q000097:blood* / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D017713:Platelet Transfusion; D013997:Time Factors
keywords: Corrected count increment; Immune suppression; Platelet; Transfusion