title: Mumps virus encephalomyelitis in a 19-year old male patient with an undefined severe combined immunodeficiency post-haematopoietic bone marrow transplantation: a rare fatal complication.
abstract: We describe a rare case of fatal mumps encephalomyelitis occurring in 19-year old male following matched unrelated donor peripheral blood haematopoietic stem cell transplantation (HSCT). The indication for HSCT was for an undefined form of severe combined immunodeficiency (SCID). Molecular typing of the mumps viral RNA isolated from neural tissue indicated that the infection was acquired at the time of a mumps outbreak in England and Wales that occurred between 2004 and 2006. This case highlights the importance of considering mumps in the differential diagnosis of central nervous system infection in highly immunosuppressed patients.
authors.affiliation: Wessex Blood and Marrow Transplantation Programme, Department of Haematology, Southampton University Hospitals Trust, SO16 6YD, UK.
authors.forename: Toby A
authors.initials: TA
authors.lastname: Eyre
authors.forename: Emanuela
authors.initials: E
authors.lastname: Pelosi
authors.forename: Stephen
authors.initials: S
authors.lastname: McQuaid
authors.forename: Deborah
authors.initials: D
authors.lastname: Richardson
authors.forename: Joan
authors.initials: J
authors.lastname: Newman
authors.forename: Kate
authors.initials: K
authors.lastname: Hill
authors.forename: Paul
authors.initials: P
authors.lastname: Veys
authors.forename: Graham
authors.initials: G
authors.lastname: Davies
authors.forename: Kim H
authors.initials: KH
authors.lastname: Orchard
mesh_terms: D000328:Adult; D004679:Encephalomyelitis / Q000150:complications* / Q000821:virology*; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009107:Mumps / Q000150:complications* / Q000821:virology; D009109:Mumps virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D016511:Severe Combined Immunodeficiency / Q000628:therapy*; D055815:Young Adult