title: Complete resection of recurrent and initially unresectable dermatofibrosarcoma protuberans downsized by Imatinib.
abstract: Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors.
authors.affiliation: Department of Surgical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands.
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Wicherts
authors.forename: Frits
authors.initials: F
authors.lastname: van Coevorden
authors.forename: Houke M
authors.initials: HM
authors.lastname: Klomp
authors.forename: Martine A
authors.initials: MA
authors.lastname: van Huizum
authors.forename: J Martijn
authors.initials: JM
authors.lastname: Kerst
authors.forename: Rick L M
authors.initials: RL
authors.lastname: Haas
authors.forename: Hester H
authors.initials: HH
authors.lastname: van Boven
authors.forename: J A
authors.initials: JA
authors.lastname: van der Hage
mesh_terms: D001549:Benzamides / Q000627:therapeutic use*; D018223:Dermatofibrosarcoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D010879:Piperazines / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate