title: HER2 Ile655Val Single Nucleotide Polymorphism in Patients with Ovarian Cancer.
abstract: BACKGROUND
  The association between HER2 Ile655Val single nucleotide polymorphism and cancer is controversial.
  
  
  OBJECTIVE
  The aim of our study was to investigate this polymorphism in patients with ovarian cancer.
  
  
  METHODS
  Genomic DNA was extracted from peripheral blood leukocytes of 107 patients and 130 healthy women. HER2 gene polymorphism was assessed by PCR-RFLP.
  
  
  RESULTS
  No significant difference was observed in genotype and allele frequency between patient and control groups according to HER2 Ile655Val polymorphism. The disease stage, age, and histological type were also not associated with the polymorphism.
  
  
  CONCLUSIONS
  Our data showed that HER2 Ile655Val single nucleotide polymorphism was not significantly associated with onset, histological type, age, and stage of ovarian cancer in Iranian patients.
authors.affiliation: Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Mojtahedi
authors.forename: Nasroolah
authors.initials: N
authors.lastname: Erfani
authors.forename: Mahyar
authors.initials: M
authors.lastname: Malekzadeh
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Haghshenas
authors.forename: Abbas
authors.initials: A
authors.lastname: Ghaderi
authors.forename: Alamtaj
authors.initials: A
authors.lastname: Samsami Dehaghani
keywords: Carcinoma, Endometrioid; HER2; Polymorphism, Single Nucleotide