title: Time to menarche and final height after histrelin implant treatment for central precocious puberty.
abstract: OBJECTIVE
  To compare final height, change in body mass index (BMI), and time from end of treatment until menarche in girls with central precocious puberty treated with the histrelin implant versus depot gonadotropin releasing hormone agonist injections.
  
  
  METHODS
  Chart review, interview, and final height measurements of 2 groups of girls with central precocious puberty; triptorelin depot (TD) group: 23 girls were treated from age 8.4 ± 0.3 with monthly injections of TD, for 26.7 ± 2.5 months; histrelin implant group: 11 girls were treated from age 8.7 ± 0.3 years for 28.4 ± 3.7 months, of whom 9 initially received monthly TD injections for 1.5-39 months. Final height, BMI (pretreatment vs recent), and time between either implant removal or last injection to menarche were compared.
  
  
  RESULTS
  Time between removal of implant or last injection and menarche was 9.3 ± 1.5 (histrelin implant group) versus 16.1 ± 1.7 (TD group) months (P = .02). Predicted height at implant insertion was 156.8 ± 2.6 cm, and final height was 161.1 ± 2.0 cm (not significant [NS]). Predicted height for TD was 155.2 ± 1.9 cm and final height was 157.9 ± 1.7 cm (NS). Change from onset of treatment to final BMI-SDS for histrelin implant was -0.41 ± 0.3, and for TD was -0.03 ± 0.2 (NS).
  
  
  CONCLUSIONS
  Menarche occurred sooner after implant removal. There was no difference in final height or BMI outcomes between the 2 treatment modalities.
authors.affiliation: Hadassah-Hebrew University Medical Center, Jerusalem, Israel. dgillis@hadassah.org.il
authors.forename: David
authors.initials: D
authors.lastname: Gillis
authors.forename: Gilad
authors.initials: G
authors.lastname: Karavani
authors.forename: Harry J
authors.initials: HJ
authors.lastname: Hirsch
authors.forename: David
authors.initials: D
authors.lastname: Strich
mesh_terms: D000367:Age Factors; D001827:Body Height; D015992:Body Mass Index; D002648:Child; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D008572:Menarche; D011629:Puberty, Precocious / Q000188:drug therapy*; D017329:Triptorelin Pamoate / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D004343:Drug Implants; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; C029256:histrelin
keywords: BMI; Body mass index; CPP; Central precocious puberty; FSH; Follicle stimulating hormone; GnRHa; Gonadotropin releasing hormone agonist(s); LH; Luteinizing hormone; NS; Not significant; PAH; Predicted adult height; TD; Triptorelin depot