title: The new revolution in toxicology: the good, the bad, and the ugly.
abstract: In 2007, the United States National Academy of Sciences issued a report entitled Toxicity Testing in the 21(st) Century: A Vision and a Strategy. The report reviewed the state of the science and outlined a strategy for the future of toxicity testing. One of the more significant components of the vision established by the report was an emphasis on toxicity testing in human rather than animal systems. In the context of drug development, it is critical that the tools used to accomplish this strategy are maximally capable of evaluating human risk. Since 2007, many advances toward implementation of this vision have been achieved, particularly with regard to safety assessment of new chemical entities intended for pharmaceutical use.
authors.affiliation: Toxicology and Pharmacology Branch, Developmental Therapeutics Program Division of Cancer Treatment and Diagnosis, The National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA. davismillinm@mail.nih.gov
authors.forename: Myrtle
authors.initials: M
authors.lastname: Davis
authors.forename: Kim
authors.initials: K
authors.lastname: Boekelheide
authors.forename: Darrell R
authors.initials: DR
authors.lastname: Boverhof
authors.forename: Gary
authors.initials: G
authors.lastname: Eichenbaum
authors.forename: Thomas
authors.initials: T
authors.lastname: Hartung
authors.forename: Michael P
authors.initials: MP
authors.lastname: Holsapple
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Jones
authors.forename: Ann M
authors.initials: AM
authors.lastname: Richard
authors.forename: Paul B
authors.initials: PB
authors.lastname: Watkins
mesh_terms: D000826:Animal Testing Alternatives / Q000639:trends; D000818:Animals; D054316:Biomarkers, Pharmacological; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D009307:National Academy of Sciences, U.S.; D018570:Risk Assessment; D018675:Toxicity Tests; D014116:Toxicology / Q000379:methods*; D014481:United States
chemical_list: D054316:Biomarkers, Pharmacological