title: Overexpression of JAKMIP1 associates with Wnt/β-catenin pathway activation and promotes cancer cell proliferation in vitro.
abstract: JAKMIP1 is a member of the recently characterized JAKMIP1 family of proteins. It has been suggested that JAKMIP1 may play a role in various cell programs, such as cytoskeleton rearrangement, cell polarization, intracellular transport or even cell signaling activities. We examined its protein expression in tumor and followed it with a model that captures its impact on activities of some tumor-linked signaling pathways as well as how its upregulation affects cell proliferation. Here, we demonstrate that JAKMIP1 is highly expressed in tumor samples than in normal tissues. Additionally, higher expression of this protein may activate Wnt signaling activity, potentiate beta-catenin accumulation and enhance proliferation of cancer cells.
authors.affiliation: Department of Histology and Embryology, Dalian Medical University, 9 Western Section, Lvshun South Road, Lvshunkou District, Dalian 11044, China.
authors.forename: Isaac
authors.initials: I
authors.lastname: Okai
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.forename: Linlin
authors.initials: L
authors.lastname: Gong
authors.forename: Benjamin
authors.initials: B
authors.lastname: Arko-Boham
authors.forename: Lihong
authors.initials: L
authors.lastname: Hao
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Qi
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Shujuan
authors.initials: S
authors.lastname: Shao
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis / Q000235:genetics*; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006367:HeLa Cells; D006801:Humans; D016601:RNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C484851:JAKMIP1 protein, human; D016601:RNA-Binding Proteins; D051176:beta Catenin