title: Sarcoidosis and Sjögren's syndrome: clinical and salivary evaluation.
abstract: BACKGROUND
  Sarcoidosis and Sjögren's syndrome are two different diseases; however, when affecting the salivary glands, both diseases exhibit similar clinical signs and symptoms, which often complicates the diagnosis. The purpose of this study was to investigate the possibility of using salivary electrophoresis to differentiate between the two diseases.
  
  
  METHODS
  Saliva was collected from patients with sarcoidosis and patients with Sjögren's syndrome. Salivary flow rate, total protein, and electrophoretic profiles were examined.
  
  
  RESULTS
  Mean salivary flow rate was 0.41 ± 0.07 ml/min/gland vs. 0.43 ± 0.07 ml/min/gland; total salivary protein was 130.0 ± 29.2 mg% vs. 104.0 ± 8.8 mg% for sarcoidosis vs. Sjögren's syndrome, respectively. No differences were observed in salivary flow rate, total salivary protein, or electrophoretic profile between patients with sarcoidosis and patients with Sjögren's syndrome (P = 0.768, 0.718, and 1.000, respectively).
  
  
  CONCLUSIONS
  Salivary protein electrophoresis does not appear to be useful to differentiate between sarcoidosis and Sjögren's syndrome.
authors.affiliation: Private Practice, Dallas, TX, USA.
authors.forename: Mohammed J
authors.initials: MJ
authors.lastname: Mansour
authors.forename: Cixin
authors.initials: C
authors.lastname: He
authors.forename: Sharif T
authors.initials: ST
authors.lastname: Al-Farra
authors.forename: Sadik A
authors.initials: SA
authors.lastname: Khuder
authors.forename: John M
authors.initials: JM
authors.lastname: Wright
authors.forename: Harvey P
authors.initials: HP
authors.lastname: Kessler
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hinton
authors.forename: Ibtisam
authors.initials: I
authors.lastname: Al-Hashimi
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003371:Cough / Q000175:diagnosis; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000175:diagnosis; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007525:Isoelectric Focusing / Q000379:methods; D008297:Male; D008875:Middle Aged; D009668:Nose Diseases / Q000175:diagnosis; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012466:Salivary Gland Diseases / Q000175:diagnosis*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D012507:Sarcoidosis / Q000175:diagnosis*; D012636:Secretory Rate / Q000502:physiology; D012793:Sialadenitis / Q000175:diagnosis; D012859:Sjogren's Syndrome / Q000175:diagnosis*; D013651:Taste Disorders / Q000175:diagnosis; D014985:Xerophthalmia / Q000175:diagnosis; D014987:Xerostomia / Q000175:diagnosis
chemical_list: D012471:Salivary Proteins and Peptides
keywords: Sjögren's syndrome; diagnosis; gel electrophoresis; salivary flow rate; salivary protein; sarcoidosis; xerostomia