title: An update on mouse brain tumor models in cancer drug discovery.
abstract: Gliomas and medulloblastomas are the most common primary brain tumors in adults and children, respectively. Although the standard of care for gliomas may have evolved slightly over the last 50 years, the clinical outcome of this disease remains unchanged. Therefore, further research to improve the treatment modalities is urgently needed. An important step forward is the use of genetically and histologically accurate mouse glioma models that mimic the human tumors in their native microenvironment in order to fully understand the biology and mechanistic causes of this disease. Such strategy will help us to identify novel targets for therapies and use these models for preclinical testing.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, Department of Cancer Biology and Genetics, 1275 York Avenue, New York, NY 10021, USA.
authors.forename: Dolores
authors.initials: D
authors.lastname: Hambardzumyan
authors.forename: Yelena
authors.initials: Y
authors.lastname: Lyustikman
authors.forename: Eric C
authors.initials: EC
authors.lastname: Holland