title: Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy.
abstract: OBJECTIVE
  To explore whether serotonin-related gene polymorphisms influence clinical outcomes of IVF treatment in recipients using donated oocytes.
  
  
  METHODS
  Nested case-control study.
  
  
  METHODS
  University-affiliated infertility clinic.
  
  
  METHODS
  Two hundred forty-five women undergoing IVF treatment with donated oocytes.
  
  
  METHODS
  None.
  
  
  METHODS
  Genotype and haplotype analysis of the serotonin transporter-linked polymorphic region (5-HTTLPR), rs1800532, rs6295, rs6313, and rs3813929, between recipients grouped according to the results of the oocyte donation for IVF treatment.
  
  
  RESULTS
  No differences were found between genotype distribution of the tryptophan hydroxylase 1, serotonin receptor 2A, and serotonin receptor 2C polymorphisms. Recipients carrying the LL genotype for 5-HTTLPR had lower clinical pregnancy rates (PR) and higher biochemical pregnancy loss (BPL) events. Lower implantation rates were found in CC carriers for 5-HT1A.rs6295 who also presented higher BPL rates. A lower incidence of clinical pregnancy was observed for LC haplotypes, corresponding to an increase in BPL rates.
  
  
  CONCLUSIONS
  A strong association was found between early pregnancy loss and recipients carrying the 5-HTTLPR and rs6295 genetic variants. Identifying biological processes involving serotonin and embryo implantation may help to understand the dynamics of the maternal-embryo dialogue.
authors.affiliation: Instituto de Fertilidad Clínica Rincón, IVF Laboratory and I+D+i Unit, Malaga, Spain. arturolrp@fertilidadclinicarincon.com
authors.forename: Arturo R
authors.initials: AR
authors.lastname: Palomares
authors.forename: Ana M
authors.initials: AM
authors.lastname: Lendínez-Ramírez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Pérez-Nevot
authors.forename: Miriam
authors.initials: M
authors.lastname: Cortés-Rodríguez
authors.forename: Francisco
authors.initials: F
authors.lastname: Martínez
authors.forename: Nicolás
authors.initials: N
authors.lastname: Garrido
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Ruiz-Galdón
authors.forename: Armando
authors.initials: A
authors.lastname: Reyes-Engel
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics* / Q000503:physiopathology; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D010064:Embryo Implantation / Q000235:genetics*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D018587:Oocyte Donation; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A