title: Effect of CdCl2 on Regulatory Volume Decrease (RVD) in Mytilus galloprovincialis digestive cells.
abstract: This study investigated the role of cadmium, a widespread heavy metal in the aquatic environment, on cell volume regulation of digestive cells isolated from the digestive gland of Mytilus galloprovincialis. These cells when exposed to a rapid change (from 1100 to 800 mOsm/kg) of the bathing solution osmolality swelled but thereafter underwent a Regulatory Volume Decrease (RVD), tending to recover the original size. This homeostatic response is altered by cadmium, as suggested by experiments performed both on isolated cells pre-incubated with cadmium (10(-5)M) and on cells isolated from animals exposed to sub-lethal concentrations of the metal (40 μg/l for 21 days). It is suggested that cytoskeleton and Na(+)/K(+)ATPase are the possible targets of cadmium which impairment is responsible of the altered homeostatic response.
authors.affiliation: Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy. ftrischi@unime.it
authors.forename: A
authors.initials: A
authors.lastname: Torre
authors.forename: F
authors.initials: F
authors.lastname: Trischitta
authors.forename: C
authors.initials: C
authors.lastname: Faggio
mesh_terms: D000818:Animals; D019256:Cadmium Chloride / Q000633:toxicity*; D048429:Cell Size / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D041981:Gastrointestinal Tract / Q000166:cytology*; D006706:Homeostasis; D007038:Hypotonic Solutions / Q000494:pharmacology; D049878:Mytilus; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D007038:Hypotonic Solutions; D014874:Water Pollutants, Chemical; D019256:Cadmium Chloride