title: Surface-functionalized nanoparticles for biosensing and imaging-guided therapeutics.
abstract: In this article, the very recent progress of various functional inorganic nanomaterials is reviewed including their unique properties, surface functionalization strategies, and applications in biosensing and imaging-guided therapeutics. The proper surface functionalization renders them with stability, biocompatibility and functionality in physiological environments, and further enables their targeted use in bioapplications after bioconjugation via selective and specific recognition. The surface-functionalized nanoprobes using the most actively studied nanoparticles (i.e., gold nanoparticles, quantum dots, upconversion nanoparticles, and magnetic nanoparticles) make them an excellent platform for a wide range of bioapplications. With more efforts in recent years, they have been widely developed as labeling probes to detect various biological species such as proteins, nucleic acids and ions, and extensively employed as imaging probes to guide therapeutics such as drug/gene delivery and photothermal/photodynamic therapy.
authors.affiliation: Institute of Materials Research and Engineering, A*STAR, 3 Research Link, Singapore 117602.
authors.forename: Shan
authors.initials: S
authors.lastname: Jiang
authors.forename: Khin Yin
authors.initials: KY
authors.lastname: Win
authors.forename: Shuhua
authors.initials: S
authors.lastname: Liu
authors.forename: Choon Peng
authors.initials: CP
authors.lastname: Teng
authors.forename: Yuangang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Han
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003952:Diagnostic Imaging / Q000295:instrumentation*; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D045663:Quantum Dots; D012822:Silicon Dioxide / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D020099:Coated Materials, Biocompatible; D058185:Magnetite Nanoparticles; D011108:Polymers; D006046:Gold; D012822:Silicon Dioxide