title: Combined general-epidural anesthesia with continuous postoperative epidural analgesia preserves sigmoid colon perfusion in elective infrarenal aortic aneurysm repair.
abstract: BACKGROUND
  In elective open infrarenal aortic aneurysm repair the use of epidural anesthesia and analgesia may preserve splanchnic perfusion. The aim of this study was to investigate the effects of epidural anesthesia on gut perfusion with gastrointestinal tonometry in patients undergoing aortic reconstructive surgery.
  
  
  METHODS
  THIRTY PATIENTS, SCHEDULED TO UNDERGO AN ELECTIVE INFRARENAL ABDOMINAL AORTIC RECONSTRUCTIVE PROCEDURE WERE RANDOMIZED IN TWO GROUPS: the epidural anesthesia group (Group A, n=16) and the control group (Group B, n=14). After induction of anesthesia, a transanally inserted sigmoid tonometer was placed for the measurement of sigmoid and gastric intramucosal CO2 levels and the calculation of regional-arterial CO2 difference (ΔPCO2). Additional measurements included mean arterial pressure (MAP), cardiac output (CO), systemic vascular resistance (SVR), and arterial lactate levels.
  
  
  RESULTS
  There were no significant intra- and inter-group differences for MAP, CO, SVR, and arterial lactate levels. Sigmoid pH and PCO2 increased in both the groups, but this increase was significantly higher in Group B, 20 min after aortic clamping and 10 min after aortic declamping.
  
  
  CONCLUSIONS
  Patients receiving epidural anesthesia during abdominal aortic reconstruction appear to have less severe disturbances of sigmoid perfusion compared with patients not receiving epidural anesthesia. Further studies are needed to verify these results.
authors.affiliation: Department of Anesthesiology, "Hippokration", Vascular Surgery Unit, University of Athens Medical School, "Hippokration" Hospital of Athens, Athens, Greece.
authors.forename: Venetiana
authors.initials: V
authors.lastname: Panaretou
authors.forename: Ioanna
authors.initials: I
authors.lastname: Siafaka
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Theodorou
authors.forename: Andreas
authors.initials: A
authors.lastname: Manouras
authors.forename: Charalampos
authors.initials: C
authors.lastname: Seretis
authors.forename: Stavros
authors.initials: S
authors.lastname: Gourgiotis
authors.forename: Stylianos
authors.initials: S
authors.lastname: Katsaragakis
authors.forename: Fragiska
authors.initials: F
authors.lastname: Sigala
authors.forename: George
authors.initials: G
authors.lastname: Zografos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Filis
keywords: Anesthesia; aorta; epidural analgesia; intestinal tonometry; splanchnic perfusion