title: Dynamic integration of splicing within gene regulatory pathways.
abstract: Precursor mRNA splicing is one of the most highly regulated processes in metazoan species. In addition to generating vast repertoires of RNAs and proteins, splicing has a profound impact on other gene regulatory layers, including mRNA transcription, turnover, transport, and translation. Conversely, factors regulating chromatin and transcription complexes impact the splicing process. This extensive crosstalk between gene regulatory layers takes advantage of dynamic spatial, physical, and temporal organizational properties of the cell nucleus, and further emphasizes the importance of developing a multidimensional understanding of splicing control.
authors.affiliation: Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, ON M5S 1A8, Canada.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Braunschweig
authors.forename: Serge
authors.initials: S
authors.lastname: Gueroussov
authors.forename: Alex M
authors.initials: AM
authors.lastname: Plocik
authors.forename: Brenton R
authors.initials: BR
authors.lastname: Graveley
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Blencowe
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics; D002843:Chromatin / Q000378:metabolism; D053263:Gene Regulatory Networks; D006801:Humans; D012326:RNA Splicing; D038621:Regulatory Sequences, Ribonucleic Acid; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D038621:Regulatory Sequences, Ribonucleic Acid