title: [Impact of hepatitis B virus infection on liver function after hematopoietic stem cell transplantation].
abstract: To analyze the impact of hepatitis B virus (HBV) infection on liver function of patients after hematopoietic stem cell transplantation (HSCT), the transplantation outcome of 48 patients infected with HBV prior to transplantation among 185 patients received HSCT was investigated retrospectively. The results showed that during a follow-up for 6 months after HSCT, the alanine aminotransferase (ALT) peak average values of the patients with HBsAg(+), HBsAb(+) and control groups were (281.6 ± 414.6), (95.4 ± 79.9) and (65.1 ± 44.2) U/L, respectively. The incidences of abnormal liver function of the patients with HBsAg(+), HBsAb(+) and control groups were 61.54%, 40.00% and 30.23% respectively. There were no significant differences between any two groups (P > 0.05). The lethality of those patients at late period after transplantation was not related to HBV infection. The hepatocirrhosis and hepatocarcinoma caused by HBV infection have not become major problems in long-term survivors. It is concluded that in HBsAg(+) patients received HSCT, the damage of liver function is more severe than control group, possibly increasing the development of abnormal liver function. The measures against the liver function damage should be taken. The prophylactic administration of ganciclovir for virus may be effective to prevent the activation of HBV.
authors.affiliation: Department of Hematology, 537 Hospital of PLA, Shanxi Province, China. leon0906@gmail.com
authors.forename: Dong-Ping
authors.initials: DP
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Guang-Wen
authors.initials: GW
authors.lastname: Li
authors.forename: Zong-Ke
authors.initials: ZK
authors.lastname: Gao
authors.forename: Zeng-Qiang
authors.initials: ZQ
authors.lastname: Zhao
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liang
authors.forename: Chao-Lang
authors.initials: CL
authors.lastname: Wei
authors.forename: Bo-Long
authors.initials: BL
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology / Q000517:prevention & control; D006509:Hepatitis B / Q000503:physiopathology*; D006515:Hepatitis B virus; D006801:Humans; D008099:Liver / Q000503:physiopathology* / Q000821:virology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult