title: A robust hybrid approach based on estimation of distribution algorithm and support vector machine for hunting candidate disease genes.
abstract: Microarray data are high dimension with high noise ratio and relatively small sample size, which makes it a challenge to use microarray data to identify candidate disease genes. Here, we have presented a hybrid method that combines estimation of distribution algorithm with support vector machine for selection of key feature genes. We have benchmarked the method using the microarray data of both diffuse B cell lymphoma and colon cancer to demonstrate its performance for identifying key features from the profile data of high-dimension gene expression. The method was compared with a probabilistic model based on genetic algorithm and another hybrid method based on both genetics algorithm and support vector machine. The results showed that the proposed method provides new computational strategy for hunting candidate disease genes from the profile data of disease gene expression. The selected candidate disease genes may help to improve the diagnosis and treatment for diseases.
authors.affiliation: Division of Medical Genetics, Tongji University School of Medicine, Shanghai 200092, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Hongmei
authors.initials: H
authors.lastname: Chen
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zhang
authors.forename: Lihua
authors.initials: L
authors.lastname: Bai
authors.forename: Yihan
authors.initials: Y
authors.lastname: Chen
authors.forename: Luying
authors.initials: L
authors.lastname: Peng
mesh_terms: D000465:Algorithms; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D015894:Genome, Human; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000235:genetics; D015233:Models, Statistical; D020411:Oligonucleotide Array Sequence Analysis; D012680:Sensitivity and Specificity; D060388:Support Vector Machine; D059467:Transcriptome