title: Interference of xenoestrogen o,p'-DDT on the action of endogenous estrogens at environmentally realistic concentrations.
abstract: Estrogenic effects of individual chemicals and mixtures of 17β-estradiol (E2) and o,p'-DDT were examined using pS2 and PR gene expressions in MCF-7 cells. Interactions between E2 and o,p'-DDT were evaluated by a statistical method based on factorial design. At levels close to environmentally realistic concentrations, no significant interactions between E2 and o,p'-DDT were observed, suggesting that the xenoestrogen (o,p'-DDT) could act in an additive way with the endogenous estrogen (E2). These results demonstrated the utility of this statistical method in a mixture study, and highlight the potential interference and health risk of low-level xenoestrogens, such as o,p'-DDT.
authors.affiliation: School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
authors.forename: Lingying
authors.initials: L
authors.lastname: Zhong
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiang
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Pei
authors.initials: P
authors.lastname: Zhou
authors.forename: Lumei
authors.initials: L
authors.lastname: Wang
mesh_terms: D003634:DDT / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D052244:Endocrine Disruptors / Q000633:toxicity; D004785:Environmental Pollutants / Q000633:toxicity; D004958:Estradiol / Q000633:toxicity; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D061986:MCF-7 Cells; D053766:Presenilin-2 / Q000235:genetics / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D004968:Estrogens, Non-Steroidal; C508861:PSEN2 protein, human; D053766:Presenilin-2; D011980:Receptors, Progesterone; D004958:Estradiol; D003634:DDT; C016340:o,p'-DDT