title: High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers.
abstract: OBJECTIVE
  To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.
  
  
  METHODS
  The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).
  
  
  RESULTS
  The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.
  
  
  CONCLUSIONS
  Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.
authors.affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital/China Medical University, Shenyang, Liaoning Province, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Hu
authors.forename: Jian
authors.initials: J
authors.lastname: Gao
authors.forename: Danye
authors.initials: D
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Limei
authors.initials: L
authors.lastname: Yan
authors.forename: Lili
authors.initials: L
authors.lastname: Gao
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Liu
authors.forename: Dawo
authors.initials: D
authors.lastname: Liu
authors.forename: Shulan
authors.initials: S
authors.lastname: Zhang
authors.forename: Bei
authors.initials: B
authors.lastname: Lin
mesh_terms: D000077216:Carcinoma, Ovarian Epithelial; D019008:Drug Resistance, Neoplasm / Q000276:immunology*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000276:immunology*; D007150:Immunohistochemistry; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy* / Q000276:immunology; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000276:immunology
chemical_list: D018960:Hyaluronan Receptors; D007983:Lewis Blood Group Antigens; C094162:Lewis Y antigen