title: Folic Acid and coenzyme q10 ameliorate cognitive dysfunction in the rats with intracerebroventricular injection of streptozotocin.
abstract: OBJECTIVE
  The present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme Q10 (CoQ10) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (ICV-STZ), an animal model of sporadic type of Alzheimer's disease.
  
  
  METHODS
  The lesion groups were injected bilaterally with ICV-STZ (1.5 mg/kg b.wt., in normal saline). In the treated groups, rats received folic acid (4 mg/kg; i.p.) or CoQ10 (10 mg/kg; i.p.), either alone or together, for 21 days. Passive avoidance learning test was used for evaluation of learning and memory.
  
  
  RESULTS
  The results showed that learning and memory performance was significantly impaired in the rats with ICV-STZ (P< 0.001), however CoQ10 and folic acid, either alone or together, prevented impairments significantly (P< 0.001), as there was not any significant difference between these treated lesion groups and control group.
  
  
  CONCLUSIONS
  The present results suggest that CoQ10 and folic acid have therapeutic and preventive effects on cognitive impairments in Alzheimer's disease.
authors.affiliation: Department of Basic Sciences, Isfahan Payame Noor University, Isfahan, Ira n.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Dehghani Dolatabadi
authors.forename: Parham
authors.initials: P
authors.lastname: Reisi
authors.forename: Hojjatallah
authors.initials: H
authors.lastname: Alaei
authors.forename: Hamid
authors.initials: H
authors.lastname: Azizi Malekabadi
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Pilehvarian
keywords: Alzheimer disease; Coenzyme Q10; Folic acid; Passive avoidance learning; Streptozotocin.