title: Identification of a nitric oxide generation-stimulative principle in Scutellariae radix.
abstract: Scutellariae radix (SR, from the roots of Scutellaria baicalensis Georgi) is thought to regulate blood pressure. In this study, HPLC-based purification coupled with MS, NMR analysis revealed that baicalin, a major flavone in SR, stimulates endothelial NO generation, suggesting its potential as an ingredient in medicinal food and beverage to treat hypertension.
authors.affiliation: United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Japan.
authors.forename: Ziyang
authors.initials: Z
authors.lastname: Chen
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nihei
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Uda
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Kabuyama
mesh_terms: D005419:Flavonoids / Q000494:pharmacology; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis*; D010936:Plant Extracts / Q000494:pharmacology*; D031364:Scutellaria baicalensis / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; D009569:Nitric Oxide; C038044:baicalin