title: Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells.
abstract: We studied molecular mechanisms of immunoprotective effects of two dipeptides, AB-O and R-1, on cultured human and rat thymic cells. Both dipeptides were shown to increase the expression of lymphocyte differentiation marker CD5 in thymic cells. Dipeptide AB-O induced T-cells precursor differentiation towards CD4(+)T-helpers and its effect was weaker than that of dipeptide R-1. Dipeptide R-1 stimulates differentiation of CD5(+) cells to mature T-helpers and cytotoxic CD8(+) T cells and hence can be considered as a bioactive substance possessing immunomodulator and antiallergic activity.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, Russian Academy of Medical Sciences, St. Petersburg, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Sevostianova
authors.forename: N S
authors.initials: NS
authors.lastname: Linkova
authors.forename: V O
authors.initials: VO
authors.lastname: Polyakova
authors.forename: N A
authors.initials: NA
authors.lastname: Chervyakova
authors.forename: A V
authors.initials: AV
authors.lastname: Kostylev
authors.forename: A O
authors.initials: AO
authors.lastname: Durnova
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoy
authors.forename: R I
authors.initials: RI
authors.lastname: Abdulragimov
authors.forename: V H
authors.initials: VH
authors.lastname: Khavinson
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D004151:Dipeptides / Q000494:pharmacology*; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000187:drug effects; D013950:Thymus Gland / Q000166:cytology*
chemical_list: D004151:Dipeptides; C415909:lysylglutamic acid