title: Evaluation of racial differences in resting and postprandial endothelial function in postmenopausal women matched for age, fitness and body composition.
abstract: OBJECTIVE
  We investigated endothelial function at rest and after a high-fat meal challenge in African American (AA) and Caucasian postmenopausal women matched for age, body mass index, percent fat and fitness level.
  
  
  METHODS
  Pilot study.
  
  
  METHODS
  University of Virginia General Clinical Research Center.
  
  
  METHODS
  Eight AA and 8 Caucasian postmenopausal women.
  
  
  METHODS
  PARTICIPANTS underwent a VO2 peak treadmill protocol, percent fat assessment, and brachial artery flow-mediated dilation measurements (baseline and 4 hours following a high-fat meal).
  
  
  METHODS
  Baseline and postprandial flow mediated dilation (FMD) following a high-fat meal.
  
  
  RESULTS
  FMD values were similar in AA (5.4%, 95% CI: 3.3, 7.4) and Caucasian women (4.0%, 95% CI: 2.0, 6.1). There was no significant change in FMD from baseline to four hours following the meal challenge within groups (AA: .9%, P = .397, Caucasian: 2.3%, P = .063) or between groups (P = .449), despite a significant increase in triglycerides (AA: 81.8 mg/dL, P < .001, Caucasian: 99.7 mg/dL, P = .004).
  
  
  CONCLUSIONS
  The present pilot study found that when postmenopausal AA and Caucasian women are matched for age, fitness and body composition, reported racial differences in resting endothelial function were not observed. Additionally, there were no racial differences in postprandial endothelial function or metabolism following a high-fat meal.
authors.affiliation: Department of Human Services, General Clinical Research Center, University of Virginia, Charlottesville, Virginia, USA. Damon.Swift@pbrc.edu
authors.forename: Damon L
authors.initials: DL
authors.lastname: Swift
authors.forename: Judith Y
authors.initials: JY
authors.lastname: Weltman
authors.forename: James T
authors.initials: JT
authors.lastname: Patrie
authors.forename: Eugene J
authors.initials: EJ
authors.lastname: Barrett
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Gaesser
authors.forename: Arthur
authors.initials: A
authors.lastname: Weltman
mesh_terms: D001741:Black or African American; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D001916:Brachial Artery / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D010101:Oxygen Consumption; D010809:Physical Fitness; D010865:Pilot Projects; D017698:Postmenopause / Q000502:physiology; D019518:Postprandial Period / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D014664:Vasodilation / Q000502:physiology; D044465:White People
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides