title: Development and evaluation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and polycaprolactone microparticles of nimodipine.
abstract: Polymeric microparticles containing the calcium channel blocker nimodipine were successfully obtained through simple emulsion/ organic solvent evaporating method. The extended release formulations, composed by the polymers poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV) and polycaprolactone (PCL), were submitted to characterization through X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TG), Fourier transform infrared analysis (FT-IR) and determination of the mean particle diameter. All formulations obtained revealed an amorphous characteristic, proven through XRPD and DSC results. Besides, no chemical interaction was observed between drug and polymer in polymeric microparticles. PHBV-NMP formulation showed a higher drug entrapment, a larger particle size, a thermal degradation behavior similar to that observed for nimodipine and a longer drug release time, being selected for in vivo evaluation. The PHBV-NMP polymeric microparticles were able to keep the pharmacological antihypertensive effect for a longer period of time, becoming a good alternative to control nimodipine release in hypertension treatment.
authors.forename: Manoela K
authors.initials: MK
authors.lastname: Riekes
authors.forename: Luiz R Olchanheski
authors.initials: LR
authors.lastname: Junior
authors.forename: Rafael N
authors.initials: RN
authors.lastname: Pereira
authors.forename: Paola A A
authors.initials: PA
authors.lastname: Borba
authors.forename: Daniel
authors.initials: D
authors.lastname: Fernandes
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianopolis, SC 88040- 970, Brazil. hellen.stulzer@gmail.com.
authors.forename: Hellen K
authors.initials: HK
authors.lastname: Stulzer
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D008863:Microspheres; D009553:Nimodipine / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D011091:Polyesters / Q000008:administration & dosage* / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014961:X-Ray Diffraction; D000094122:Polyhydroxybutyrates
chemical_list: D009553:Nimodipine; D011091:Polyesters; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates; C016240:polycaprolactone