title: Significant decrease in plasma midregional proadrenomedullin level in patients with end-stage renal disease after living kidney transplantation.
abstract: Impaired renal function has been suggested to significantly impact plasma midregional proADM (MR-proADM) level. The aim of this study was to assess whether improvement of renal function after living kidney transplantation has an impact on plasma MR-proADM-like immunoreactive substance (IS) level. Eleven patients with end-stage renal disease (ESRD) who were scheduled to undergo the first living kidney allograft transplantation were enrolled. Plasma MR-proADM-IS levels were measured before and 3, 7, 10, 14, 21, 30, 60 and 90 days after kidney transplantation. Plasma MR-proADM-IS level decreased significantly from day 3 after kidney transplantation compared to before kidney transplantation. A significant negative correlation was observed between creatinine clearance and plasma MR-proADM-IS level from before to 90 days after kidney transplantation (rs=-0.70, p<0.0001). These results suggest that recovery of kidney function after kidney transplantation may lead to decrease in plasma MR-proADM level in patients with ESRD, and that plasma MR-proADM level may depend largely on renal function.
authors.affiliation: Department of Clinical Pharmacy, Oita University Hospital, Hasama-machi, Oita 879-5593, Japan. y-suzuki@oita-u.ac.jp
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Itoh
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Katagiri
authors.forename: Fuminori
authors.initials: F
authors.lastname: Sato
authors.forename: Kanako
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Yukie
authors.initials: Y
authors.lastname: Sato
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Sato
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Mimata
authors.forename: Masaharu
authors.initials: M
authors.lastname: Takeyama
mesh_terms: D053607:Adrenomedullin / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood*
chemical_list: D011498:Protein Precursors; C088633:proadrenomedullin; D053607:Adrenomedullin