title: Exercise-related complications in sickle cell trait.
abstract: This review presents the epidemiological data regarding the exercise-related complication in exercising sickle cell trait carriers, and focuses on the different potential mechanisms that could be involved in these adverse events, such as hemorheological alterations, inflammation, vascular adhesion of circulating blood cells, oxidative stress and impaired nitric oxide metabolism. We also discuss the effects of different modulating factors such as vascular function, environment (hot temperature), hydration status, physical fitness, exercise intensity and genetic factors.
authors.affiliation: Department of Exercise Physiology, National Institute of Health and Nutrition, Shinjuku, Tokyo, Japan.
authors.forename: Julien
authors.initials: J
authors.lastname: Tripette
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Hardy-Dessources
authors.forename: Marc
authors.initials: M
authors.lastname: Romana
authors.forename: Olivier
authors.initials: O
authors.lastname: Hue
authors.forename: Mor
authors.initials: M
authors.lastname: Diaw
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Samb
authors.forename: Saliou
authors.initials: S
authors.lastname: Diop
authors.forename: Philippe
authors.initials: P
authors.lastname: Connes
mesh_terms: D015444:Exercise / Q000502:physiology*; D018056:Hemorheology / Q000502:physiology; D006801:Humans; D012805:Sickle Cell Trait / Q000097:blood / Q000150:complications* / Q000503:physiopathology
keywords: Sickle cell trait; exercise-related sudden death; hemorheology; inflammation; vascular function