title: Navigation rules for vessels and neurons: cooperative signaling between VEGF and neural guidance cues.
abstract: Many organs, such as lungs, nerves, blood and lymphatic vessels, consist of complex networks that carry flows of information, gases, and nutrients within the body. The morphogenetic patterning that generates these organs involves the coordinated action of developmental signaling cues that guide migration of specialized cells. Precision guidance of endothelial tip cells by vascular endothelial growth factors (VEGFs) is well established, and several families of neural guidance molecules have been identified to exert guidance function in both the nervous and the vascular systems. This review discusses recent advances in VEGF research, focusing on the emerging role of neural guidance molecules as key regulators of VEGF function during vascular development and on the novel role of VEGFs in neural cell migration and nerve wiring.
authors.affiliation: Aix-Marseille Université, CNRS UMR 7288, IBDM, Campus de Luminy Case 908, 13288, Marseille Cedex 9, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Chauvet
authors.forename: Katja
authors.initials: K
authors.lastname: Burk
authors.forename: Fanny
authors.initials: F
authors.lastname: Mann
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism*; D006801:Humans; D042601:Lymphatic Vessels / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D039921:Neuropilins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D036081:Receptors, Eph Family / Q000378:metabolism; D039961:Semaphorins / Q000378:metabolism; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism
chemical_list: D039921:Neuropilins; D011956:Receptors, Cell Surface; D039961:Semaphorins; D042461:Vascular Endothelial Growth Factor A; D036081:Receptors, Eph Family; D040301:Vascular Endothelial Growth Factor Receptor-2