title: Dabigatran etexilate tetra-hydrate.
abstract: In the title compound, C34H41N7O5·4H2O (systematic name: ethyl 3-{[2-({4-[(Z)-amino-(hexyl-oxycarbonyl-imino)-meth-yl]anilino}meth-yl)-1-meth-yl-benzimidazole-5-carbon-yl]pyridin-2-yl-amino}-propano-ate tetra-hydrate), the benzene and pyridine rings form dihedral angles of 5.4 (1) and 43.8 (1)°, respectively, with the benzimidazole mean plane. The terminal butyl group is disordered over two conformations in a 0.756 (10):0.244 (10) ratio. There is an intramolecular N-H⋯O hydrogen bond present. In the crystal, the water mol-ecules are involved in the formation of O-H⋯O, O-H⋯N and N-H⋯O hydrogen bonds, which link the components into layers parallel to the ab plane.
authors.affiliation: State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Centre for New Drug Safety Assessment and Research, Tianjin 300193, People's Republic of China ; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, People's Republic of China.
authors.forename: Hong-Qiang
authors.initials: HQ
authors.lastname: Liu
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Zhang
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Cai
authors.forename: Wei-Ren
authors.initials: WR
authors.lastname: Xu
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Shen