title: Transient optic perineuritis as the initial presentation of central nervous system involvement by pre-B cell lymphocytic leukemia.
abstract: A 20-year-old man with a history of pre-B cell acute lymphocytic leukemia (ALL) presented with optic perineuritis of the right eye while undergoing chemotherapy. Evaluation failed to reveal an infectious or neoplastic cause, and the patient improved with oral corticosteroid treatment. He returned 10 weeks later with complete loss of vision in the right eye. Optic nerve biopsy revealed leukemic infiltration of the optic nerve, and the patient was treated for central nervous system (CNS) relapse of ALL. Transient optic perineuritis may be the initial manifestation of CNS involvement of pre-B cell ALL.
authors.affiliation: Department of Ophthalmology, Emory Eye Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Justin H
authors.initials: JH
authors.lastname: Townsend
authors.forename: Sander R
authors.initials: SR
authors.lastname: Dubovy
authors.forename: Joshua
authors.initials: J
authors.lastname: Pasol
authors.forename: Byron L
authors.initials: BL
authors.lastname: Lam
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002490:Central Nervous System / Q000473:pathology*; D005451:Fluorescein Angiography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009902:Optic Neuritis / Q000188:drug therapy / Q000503:physiopathology*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000473:pathology*; D014786:Vision Disorders / Q000209:etiology / Q000473:pathology; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones