title: An inflammatory situation: SOX2 and STAT3 cooperate in squamous cell carcinoma initiation.
abstract: Although SOX2 has been identified as a squamous cell carcinoma oncogene, mechanisms of SOX2-induce oncogenesis have remained elusive. In this issue of Cell Stem Cell, Li et al. (2013) show that SOX2 synergizes with inflammation-induced STAT3 activation to transform basal progenitors and initiate squamous cell carcinoma.
authors.affiliation: Division of Molecular and Cellular Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Bass
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Wang