title: An autonomous mobile system for the management of COPD.
abstract: BACKGROUND
  Managing chronic disease through automated systems has the potential to both benefit the patient and reduce health-care costs. We have developed and evaluated a disease management system for patients with chronic obstructive pulmonary disease (COPD). Its aim is to predict and detect exacerbations and, through this, help patients self-manage their disease to prevent hospitalisation.
  
  
  METHODS
  The carefully crafted intelligent system consists of a mobile device that is able to collect case-specific, subjective and objective, physiological data, and to alert the patient by a patient-specific interpretation of the data by means of probabilistic reasoning. Collected data are also sent to a central server for inspection by health-care professionals.
  
  
  METHODS
  We evaluated the probabilistic model using cross-validation and ROC analyses on data from an earlier study and by an independent data set. Furthermore a pilot with actual COPD patients has been conducted to test technical feasibility and to obtain user feedback.
  
  
  RESULTS
  Model evaluation results show that we can reliably detect exacerbations. Pilot study results suggest that an intervention based on this system could be successful.
authors.affiliation: Institute for Computing and Information Sciences, Radboud University Nijmegen, The Netherlands. m.vanderheijden@cs.ru.nl
authors.forename: Maarten
authors.initials: M
authors.lastname: van der Heijden
authors.forename: Peter J F
authors.initials: PJ
authors.lastname: Lucas
authors.forename: Bas
authors.initials: B
authors.lastname: Lijnse
authors.forename: Yvonne F
authors.initials: YF
authors.lastname: Heijdra
authors.forename: Tjard R J
authors.initials: TR
authors.lastname: Schermer
mesh_terms: D001185:Artificial Intelligence; D016494:Computer Security; D019468:Disease Management; D005240:Feasibility Studies; D006801:Humans; D020407:Internet; D008962:Models, Theoretical; D010865:Pilot Projects; D011336:Probability; D029424:Pulmonary Disease, Chronic Obstructive / Q000628:therapy*; D012372:ROC Curve; D017216:Telemedicine