title: Effectiveness of disinfectants used in hemodialysis against both Candida orthopsilosis and C. parapsilosis sensu stricto biofilms.
abstract: Biofilms have been observed in the fluid pathways of hemodialysis machines. The impacts of four biocides used for the disinfection of hemodialysis systems were tested against Candida parapsilosis sensu stricto and Candida orthopsilosis biofilms generated by isolates obtained from a hydraulic circuit that were collected in a hemodialysis unit. Acetic acid was shown to be the most effective agent against Candida biofilms. Strategies for effective disinfection procedures used for hemodialysis systems should also seek to kill and inhibit biofilms.
authors.affiliation: Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Univ Estadual Paulista-UNESP, Araraquara, São Paulo, Brazil.
authors.forename: Regina Helena
authors.initials: RH
authors.lastname: Pires
authors.forename: Julhiany de Fátima
authors.initials: Jde F
authors.lastname: da Silva
authors.forename: Carlos Henrique
authors.initials: CH
authors.lastname: Martins
authors.forename: Ana Marisa
authors.initials: AM
authors.lastname: Fusco Almeida
authors.forename: Christiane
authors.initials: C
authors.lastname: Pienna Soares
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Soares Mendes-Giannini
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D004202:Disinfectants / Q000494:pharmacology*; D006436:Hemodialysis Units, Hospital; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007688:Kidneys, Artificial / Q000382:microbiology*; D010463:Peracetic Acid / Q000494:pharmacology; D012973:Sodium Hypochlorite / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D004202:Disinfectants; D006861:Hydrogen Peroxide; D012973:Sodium Hypochlorite; D010463:Peracetic Acid; D019342:Acetic Acid