title: Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial.
abstract: OBJECTIVE
  Multiple sclerosis is a neurodegenerative and demyelinating disease of central nervous system. High levels of oxidative stress are associated with inflammation and play an important role in pathogenesis of multiple sclerosis. This double-blind, randomized controlled clinical study was carried out to determine the effect of daily consumption of lipoic acid on oxidative stress among multiple sclerosis patients.
  
  
  METHODS
  A total of 52 relapsing-remitting multiple sclerosis patients, aged 18-50 years with Expanded Disability Status Scale ≤5.5 were assigned to consume either lipoic acid (1200 mg/day) or placebo capsules for 12 weeks. Fasting blood samples were collected before the first dose taken and 12 hours after the last. Dietary intakes were obtained by using 3-day dietary records.
  
  
  RESULTS
  Consumption of lipoic acid resulted in a significant improvement of total antioxidant capacity (TAC) in comparison to the placebo group (P = 0.004). Although a significant change of TAC (-1511 mmol/L, P = 0.001) was found within lipoic acid group, other markers of oxidative stress including superoxide dismutase activity, glutathione peroxidase activity, and malondialdehyde levels were not affected by lipoic acid consumption.
  
  
  CONCLUSIONS
  These results suggest that 1200 mg of lipoic acid improves serum TAC among multiple sclerosis patients but does not affect other markers of oxidative stress.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khalili
authors.forename: Shahryar
authors.initials: S
authors.lastname: Eghtesadi
authors.forename: Abbas
authors.initials: A
authors.lastname: Mirshafiey
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Eskandari
authors.forename: Meisam
authors.initials: M
authors.lastname: Sanoobar
authors.forename: Mohamad Ali
authors.initials: MA
authors.lastname: Sahraian
authors.forename: Abbas
authors.initials: A
authors.lastname: Motevalian
authors.forename: Abbas
authors.initials: A
authors.lastname: Norouzi
authors.forename: Shirin
authors.initials: S
authors.lastname: Moftakhar
authors.forename: Amirreza
authors.initials: A
authors.lastname: Azimi
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood; D008063:Thioctic Acid / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008315:Malondialdehyde; D008063:Thioctic Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Glutathione peroxidase; Lipoic acid; Malondialdehyde; Multiple sclerosis; Oxidative stress; Reactive oxygen species; Superoxide dismutase; Total antioxidant capacity