title: Directing group enhanced carbonylative ring expansions of amino-substituted cyclopropanes: rhodium-catalyzed multicomponent synthesis of N-heterobicyclic enones.
abstract: Aminocyclopropanes equipped with suitable N-directing groups undergo efficient and regioselective Rh-catalyzed carbonylative C-C bond activation. Trapping of the resultant metallacycles with tethered alkynes provides an atom-economic entry to diverse N-heterobicyclic enones. These studies provide a blueprint for myriad N-heterocyclic methodologies.
authors.affiliation: School of Chemistry, University of Bristol , Bristol BS8 1TS, United Kingdom.
authors.forename: Megan H
authors.initials: MH
authors.lastname: Shaw
authors.forename: Ekaterina Y
authors.initials: EY
authors.lastname: Melikhova
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Kloer
authors.forename: William G
authors.initials: WG
authors.lastname: Whittingham
authors.forename: John F
authors.initials: JF
authors.lastname: Bower
mesh_terms: D000588:Amines / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D002384:Catalysis; D003521:Cyclopropanes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000588:Amines; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003521:Cyclopropanes; D007659:Ketones; D012238:Rhodium