title: Pharmacomechanical thrombolysis in the management of paget-schroetter syndrome.
abstract: Paget-Schroetter syndrome (PSS) is a rare form of thoracic outlet syndrome caused by axillosubclavian vein thrombosis which typically presents in healthy young adults. Prompt therapy, traditionally by means of catheter-directed thrombolysis (CDT) prior to definitive surgery, can prevent the subsequent onset of postthrombotic syndrome (PTS) and considerable disability. As CDT is associated with major haemorrhage and high overall treatment cost, pharmacomechanical thrombectomy (PMT) seems to be an attractive alternative which combines pharmacological thrombolysis with mechanical clot disruption. The Trellis-8 peripheral infusion catheter is an example of such a treatment which provides topical thrombolysis in an isolated zone. We describe the use of the Trellis-8 PMT system in the successful management of three patients with PSS.
authors.affiliation: Multidisciplinary Endovascular Team, University College London Hospitals, 235 Euston Road, London NW1 2BU, UK.
authors.forename: Elli
authors.initials: E
authors.lastname: Papantoniou
authors.forename: Luke
authors.initials: L
authors.lastname: Morgan-Rowe
authors.forename: Edward
authors.initials: E
authors.lastname: Johnston
authors.forename: Duncan
authors.initials: D
authors.lastname: Brennand
authors.forename: Jowad
authors.initials: J
authors.lastname: Raja
authors.forename: Julian
authors.initials: J
authors.lastname: Hague