title: Ruthenium(II)-catalyzed regioselective reductive coupling of α-imino esters with dienes.
abstract: A method for the highly regioselective reductive coupling reaction of N-aryl-α-imino esters with dienes is described. The method utilizes the RuHCl(CO)(PPh3)3/iPrOH catalytic system under an Ar atmosphere and provides α-branched allylic α-amino acid derivatives. Application of this transformation to the concise synthesis of a natural plant growth regulator is demonstrated.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Shujie
authors.initials: S
authors.lastname: Zhu
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Lu
authors.forename: Yueting
authors.initials: Y
authors.lastname: Luo
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
authors.forename: Wei
authors.initials: W
authors.lastname: Zeng
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004952:Esters; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D010937:Plant Growth Regulators / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000466:Alkadienes; D000596:Amino Acids; D004952:Esters; D007097:Imines; D010937:Plant Growth Regulators; D012428:Ruthenium