title: Diagnosis and surgical treatment of sporadic meningioangiomatosis.
abstract: OBJECTIVE
  To discuss the clinical characteristics, radiological features, surgical treatment and prognosis of sporadic meningioangiomatosis (MA).
  
  
  METHODS
  We retrospectively analyzed the medical records of ten histopathologically confirmed MA patients who were treated in the Department of Neurosurgery of Huashan hospital from 2002 to 2011. All of the patients presented with symptomatic seizure attacks before craniotomy surgeries. Magnetic resonance imaging (MRI) and/or computed tomography (CT) were the main radiological examination for preoperative diagnosis of all cases.
  
  
  RESULTS
  All patients underwent craniotomy surgeries with gross total resections (GTRs) of the MA lesions. Postoperative follow-ups range from 8 to 108 months, in average 42.7 months, median 40.5 months. No radiological recurrence can be found in any case. Eight patients (80.0%) have achieved total symptomatic remission after surgeries (one of them underwent delayed remission), while two (20.0%) are still suffering from seizure attacks infrequently under several antiepileptic drugs (AEDs).
  
  
  CONCLUSIONS
  Although MA cases are quite rare and usually misdiagnosed presurgically, a correct preoperative diagnosis, at least a differential diagnosis, can be rationally achieved via a triad of patients' ages, symptomatic seizure attacks and radiological features (both CT and MR). MA is curable and the prognosis is excellent since most patients became free of seizure and recurrence after surgical treatments.
authors.affiliation: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Feng
authors.forename: Jie
authors.initials: J
authors.lastname: Hu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Che
authors.forename: Li
authors.initials: L
authors.lastname: Pan
authors.forename: Zhiqiu
authors.initials: Z
authors.lastname: Wang
authors.forename: Mingguang
authors.initials: M
authors.lastname: Zhang
authors.forename: Fengping
authors.initials: F
authors.lastname: Huang
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Renling
authors.initials: R
authors.lastname: Mao
authors.forename: An
authors.initials: A
authors.lastname: Sun
authors.forename: Weimin
authors.initials: W
authors.lastname: Bao
authors.forename: Ping
authors.initials: P
authors.lastname: Zhong
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D003399:Craniotomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008579:Meningioma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery*; D009069:Movement Disorders / Q000209:etiology; D019635:Neurosurgical Procedures / Q000379:methods*; D012640:Seizures / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
keywords: Intractable seizure; Neurofibromatosis type 2 (NF2); Radiological features; Sporadic meningioangiomatosis (MA); Surgical treatment