title: [Chemical constituents of Coreopsis tinctoria].
abstract: OBJECTIVE
  To study the chemical constituents of the inflorescences of Coreopsis tinctoria and provide the chemical basis for development and utilization of this plant.
  
  
  METHODS
  Various chromatographic techniques were employed for the isolation and purification of the constituents including silica gel, Sephadex LH-20 and pre-HPLC. The structures of compounds were elucidated by chemical and spectral analysis (NMR, IR, UV and MS).
  
  
  RESULTS
  Eight compounds have been isolated from the inflorescences of C. tinctoria, including three organic acids which are 3,4-dihydroxybenzoicacid (1), 4-hydroxybenzoicacid (2) and caffeic acid (3), one organic ester which is 4-O-beta-D-glucopyranosyl-p-coumaric acid methyl ester (4), two flavonones which are 2S-3',5',7-trihydroxyflavanone (5) and (2R,3R)-3,4',5,7-tetrahydroxylflavanone (6), two sterols which are stigmasterol-3-O-beta-D-glucopyranoside (7) and beta-sitosterol (8).
  
  
  CONCLUSIONS
  Compounds 1-7 were isolated from genus Coreopsis for the first time and compound 8 was isolated first from C. tinctoria.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China. zhangyuanbjcm@gmail.com
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Tu
mesh_terms: D002851:Chromatography, High Pressure Liquid; D031945:Coreopsis / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D004365:Drugs, Chinese Herbal