title: Whole organism approaches to chemical genomics: the promising role of zebrafish (Danio rerio).
abstract: Chemical genomics is a new and rapidly developing field. It refers to the use of cell-permeable small molecules, which are highly specific for their protein targets, in order to dissect biological pathways and to discover new drug leads. Small-molecule screening is usually limited to high-throughput approaches that use defined cell lines; however, whole organism screening is gaining increasing attention. This review addresses the latter concept and highlights the advances in whole organism-based screening, with an emphasis on the use of the zebrafish (Danio rerio).
authors.affiliation: University of Auckland, School of Biological Sciences, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand +64 9 3737599 ; ext: 87228; +64 9 3737417 ; d.love@auckland.ac.nz.
authors.forename: Chuan-Ching
authors.initials: CC
authors.lastname: Lan
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurenson
authors.forename: Brent R
authors.initials: BR
authors.lastname: Copp
authors.forename: Peter M
authors.initials: PM
authors.lastname: Cattin
authors.forename: Donald R
authors.initials: DR
authors.lastname: Love