title: CoupTFI interacts with retinoic acid signaling during cortical development.
abstract: We examined the role of the orphan nuclear hormone receptor CoupTFI in mediating cortical development downstream of meningeal retinoic acid signaling. CoupTFI is a regulator of cortical development known to collaborate with retinoic acid (RA) signaling in other systems. To examine the interaction of CoupTFI and cortical RA signaling we utilized Foxc1-mutant mice in which defects in meningeal development lead to alterations in cortical development due to a reduction of RA signaling. By analyzing CoupTFI(-/-);Foxc1(H/L) double mutant mice we provide evidence that CoupTFI is required for RA rescue of the ventricular zone and the neurogenic phenotypes in Foxc1-mutants. We also found that overexpression of CoupTFI in Foxc1-mutants is sufficient to rescue the Foxc1-mutant cortical phenotype in part. These results suggest that CoupTFI collaborates with RA signaling to regulate both cortical ventricular zone progenitor cell behavior and cortical neurogenesis.
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, California, USA.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Harrison-Uy
authors.forename: Julie A
authors.initials: JA
authors.lastname: Siegenthaler
authors.forename: Andrea
authors.initials: A
authors.lastname: Faedo
authors.forename: John L R
authors.initials: JL
authors.lastname: Rubenstein
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Pleasure
mesh_terms: D000818:Animals; D051838:COUP Transcription Factor I / Q000378:metabolism*; D002540:Cerebral Cortex / Q000196:embryology*; D051858:Forkhead Transcription Factors / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D005838:Genotype; D008578:Meninges / Q000196:embryology; D051379:Mice; D009154:Mutation; D055495:Neurogenesis / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D010641:Phenotype; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology; D013997:Time Factors; D014212:Tretinoin / Q000378:metabolism*
chemical_list: D051838:COUP Transcription Factor I; D051858:Forkhead Transcription Factors; C112890:Foxc1 protein, mouse; D014212:Tretinoin