title: The role of bone marrow biopsy examination at diagnosis of chronic lymphocytic leukemia: a reappraisal.
abstract: According to the International Workshop on Chronic Lymphocytic Leukemia/National Institutes of Health (iwCLL/NIH) guidelines for the diagnosis and treatment of chronic lymphocytic leukemia (CLL), bone marrow biopsy (BMB) is not required at diagnosis, however recommended before initiating treatment. That notwithstanding, histopathological examination of the BMB has the potential to provide important information of both clinical and biological significance. Here we attempt a reappraisal of the role of BMB examination in the modern diagnostic work-up of patients with CLL, based on both the literature and our accumulated experience from the systematic and multiparametric evaluation of a large series of BMB samples taken at diagnosis of CLL. Overall, we argue that the study of BMB offers important information not only for diagnostic purposes but also for elucidating CLL pathobiology.
authors.affiliation: Hematology Department and HCT Unit, G. Papanicolaou Hospital , Thessaloniki , Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Baliakas
authors.forename: George
authors.initials: G
authors.lastname: Kanellis
authors.forename: Niki
authors.initials: N
authors.lastname: Stavroyianni
authors.forename: Maria
authors.initials: M
authors.lastname: Fameli
authors.forename: Achilles
authors.initials: A
authors.lastname: Anagnostopoulos
authors.forename: Kostas
authors.initials: K
authors.lastname: Stamatopoulos
authors.forename: Theodora
authors.initials: T
authors.lastname: Papadaki
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination; D006410:Hematopoiesis; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000473:pathology