title: Lobar hepatocellular carcinoma with ipsilateral portal vein tumor thrombosis treated with yttrium-90 glass microsphere radioembolization: preliminary results.
abstract: Portal vein tumor thrombosis (PVTT) is a common complication of hepatocellular carcinoma (HCC) and has a negative impact on prognosis. This characteristic feature led to the rationale of the present trial designed to assess the efficacy and the safety of yttrium-90 glass-microsphere treatment for advanced-stage lobar HCC with ipsilateral PVTT. 18 patients with unresectable lobar HCC and ipsilateral PVTT were treated in our institution with (90)Y-microS radioembolization. Patients were evaluated every 3 to 6 months for response, survival, and toxicity. Mean follow-up was 13.0 months (2.2-50.6). Outcomes were: complete response (n = 2), partial response (n = 13), stable disease (n = 1), and progressive disease (n = 2) giving a disease control rate of 88.9%. Four patients were downstaged. Treating lobar hepatocellular carcinoma with ipsilateral portal vein thrombosis with yttrium-90 glass-microsphere radioembolization is safe and efficacious. Further clinical trials are warranted to confirm these results and to compare (90)Y-microS with sorafenib, taking into account not only survival but also the possibility of secondary surgery for putative curative intention after downstaging.
authors.affiliation: Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, France ; University of Rennes 1, 35043 Rennes, France ; INSERM U-991 Liver Metabolisms and Cancer, 35033 Rennes, France.
authors.forename: M
authors.initials: M
authors.lastname: Pracht
authors.forename: J
authors.initials: J
authors.lastname: Edeline
authors.forename: L
authors.initials: L
authors.lastname: Lenoir
authors.forename: M
authors.initials: M
authors.lastname: Latournerie
authors.forename: H
authors.initials: H
authors.lastname: Mesbah
authors.forename: O
authors.initials: O
authors.lastname: Audrain
authors.forename: Y
authors.initials: Y
authors.lastname: Rolland
authors.forename: B
authors.initials: B
authors.lastname: Clément
authors.forename: J L
authors.initials: JL
authors.lastname: Raoul
authors.forename: E
authors.initials: E
authors.lastname: Garin
authors.forename: E
authors.initials: E
authors.lastname: Boucher