title: Effect of interpregnancy interval on outcomes of pregnancy after recurrent pregnancy loss.
abstract: OBJECTIVE
  To examine the effect of interpregnancy interval (IPI) on outcomes of pregnancy after recurrent pregnancy loss (RPL).
  
  
  METHODS
  A retrospective cohort study including 325 patients treated at a RPL clinic, with two or more consecutive pregnancy losses followed by a subsequent (index) pregnancy, of whom 163 had IPI ≤ 6 months, and 212 had IPI > 6 months.
  
  
  RESULTS
  Pregnancy loss rate in the index pregnancy was positively associated with increased IPI (18.6% in women with IPI ≤ 6 months, and 29.7% in women with IPI > 6 months; p = 0.029). In a multivariable logistic analysis, excluding women with fertility problems, and adjusting for maternal age and ethnicity, the OR for pregnancy loss rate for IPI longer than 6 months compared to shorter IPI was 1.76 (95%CI: 0.96-3.22, p = 0.067).
  
  
  CONCLUSIONS
  Our results suggest that IPI shorter than 6 months, in women with no fertility problems, is associated with lower rate of subsequent miscarriage. Further studies are needed to substantiate this finding.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. abashiri@bgu.ac.il
authors.forename: Yaara
authors.initials: Y
authors.lastname: Bentolila
authors.forename: Ronit
authors.initials: R
authors.lastname: Ratzon
authors.forename: Ilana
authors.initials: I
authors.lastname: Shoham-Vardi
authors.forename: Ruslan
authors.initials: R
authors.lastname: Serjienko
authors.forename: Moshe
authors.initials: M
authors.lastname: Mazor
authors.forename: Asher
authors.initials: A
authors.lastname: Bashiri
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology*; D000328:Adult; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D016015:Logistic Models; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult