title: Pre-filled normal saline syringes to reduce totally implantable venous access device-associated bloodstream infection: a single institution pilot study.
abstract: Flushing totally implantable venous access devices (TIVADs) with manually filled saline syringes may increase contamination and catheter-related bloodstream infection (CRBSI). We used a retrospective cohort study to assess the impact of changing from manually filled syringes to manufactured pre-filled syringes on the frequency of CRBSI in 718 TIVADs. Manually filled syringes were used in 269 patients and pre-filled syringes in 449. The CRBSI rate was 2.7% in the pre-filled syringe group and 6.3% in the manually filled syringe group (P = 0.016). Sex, tumour type and stage, access site and access body side were not independent risk factors for CRBSI.
authors.affiliation: Department of Surgical Sciences (DISC), University of Genova, Largo Rosanna Benzi 10, Genoa, Italy. sergio.bertoglio@istge.it
authors.forename: S
authors.initials: S
authors.lastname: Bertoglio
authors.forename: R
authors.initials: R
authors.lastname: Rezzo
authors.forename: F D
authors.initials: FD
authors.lastname: Merlo
authors.forename: N
authors.initials: N
authors.lastname: Solari
authors.forename: D
authors.initials: D
authors.lastname: Palombo
authors.forename: F
authors.initials: F
authors.lastname: Vassallo
authors.forename: S
authors.initials: S
authors.lastname: Beltramini
authors.forename: A
authors.initials: A
authors.lastname: DeMaria
mesh_terms: D000328:Adult; D055499:Catheter-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects; D004866:Equipment Contamination / Q000517:prevention & control*; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009369:Neoplasms / Q000382:microbiology / Q000628:therapy; D010865:Pilot Projects; D012189:Retrospective Studies; D012307:Risk Factors; D012965:Sodium Chloride; D013594:Syringes
chemical_list: D012965:Sodium Chloride