title: Bioinspired peptides as versatile nucleic acid delivery platforms.
abstract: Non-viral gene therapy approaches have strongly established the utility of peptides as integral constituents of delivery platforms devised for efficient transfer of therapeutic molecules into cells. Among these, cell-penetrating peptides (CPPs), encompassing a family of short peptide sequences and their chimeric derivatives, have gained versatility through the addition of de novo peptide ligands primarily to facilitate cell-specific nucleic acid delivery in vitro and in vivo. The review illustrates the structural requirements of a noteworthy peptide TAT-PTD and other derivatives chiefly to exemplify their implication in gene therapy. An overview of the emerging concept and recent explorations will be presented through unique examples which form a facet in nanotechnology-based cancer therapy. Finally the basis for the utility of CPPs in plants will be discussed in view of its biotechnological potential.
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad-500007, Andhra Pradesh, India. vijaya@ccmb.res.in
authors.forename: Vijaya
authors.initials: V
authors.lastname: Gopal
mesh_terms: D000818:Animals; D057846:Cell-Penetrating Peptides; D004337:Drug Carriers / Q000008:administration & dosage*; D015696:Gene Products, tat; D006801:Humans; D036103:Nanotechnology; D009696:Nucleic Acids / Q000008:administration & dosage*; D010944:Plants / Q000235:genetics
chemical_list: D057846:Cell-Penetrating Peptides; D004337:Drug Carriers; D015696:Gene Products, tat; D009696:Nucleic Acids