title: [Impact of laser therapy on PGE2 level, 24-hour pH-metry changes, and quality of life in patients with gastroesophageal reflux disease].
abstract: OBJECTIVE
  To study the impact of low-intensity laser irradiation on 24-hour pH-metry parameters and prostaglandin E2 (PGE2) levels in patients with gastroesophageal reflux disease (GERD).
  
  
  METHODS
  One hundred and twelve patients aged 19 to 79 years with GERD were examined. Seventy-eight patients received a 10-day course of continuous intravenous laser therapy using a Matrix VLOK laser therapy apparatus (Matrix, Russia) with a wavelength of 0.405 pm, radiation power at the exit of a main light guide 1-1.5 mW, pulse rate 80 Hz. The indicators under study were determined before and after treatment.
  
  
  RESULTS
  After treatment, the intravenous laser therapy group showed a significant increase in PGE2 (1376 +/- 93 pg/ml) to the levels typical of those in healthy individuals and a significant decrease in all esophageal pH-metry parameters; the DeMeester score achieved normal values, and all quality of life (QL) indicators, except for physical function index, significantly improved (10.2 +/- 5.7; p < 0.05).
  
  
  CONCLUSIONS
  The findings are suggestive of elevated PGE2 levels and improved QL during laser therapy.
authors.forename: N M
authors.initials: NM
authors.lastname: Burduli
authors.forename: D Ia
authors.initials: DIa
authors.lastname: Tadtaeva
mesh_terms: D000328:Adult; D015232:Dinoprostone / Q000097:blood / Q000528:radiation effects; D050782:Esophageal pH Monitoring; D004947:Esophagus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology / Q000532:radiotherapy; D006801:Humans; D028022:Low-Level Light Therapy / Q000379:methods / Q000523:psychology; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D057240:Patient Preference; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D015232:Dinoprostone