title: Dipeptidyl peptidase-IV and related molecules: markers of malignancy?
abstract: BACKGROUND
  The dipeptidyl peptidase-IV (DPP-IV) family has outgrown its humble origins as a simple enzymatic activity cleaving dipeptides from peptides with an accessible N-terminal penultimate proline with no clear role in metabolism. It is now understood to play a critical role in regulating signaling capacity of chemokines, neuropeptides and other extracellular messengers in addition to playing direct roles by means of non-enzymatic interactions to regulate the local extracellular proliferative environment. Consequently, examination of DPP-IV family representation and activity in immune and oncogenic processes has become a major focus.
  
  
  OBJECTIVE
  To review the evidence for DPP-IV family members as markers of malignancy.
  
  
  METHODS
  Overview of published data.
  
  
  CONCLUSIONS
  The DPP-IV family, which is probably linked directly to the pathogenesis of cancer, holds significant promise for exploitation in the diagnostic arena.
authors.affiliation: Charles University in Prague, Laboratory of Cancer Cell Biology of the 1st Faculty of Medicine, U Nemocnice 5, 128 53, Prague 2, Czech Republic, +420 728 748 692 ; +420 224 965 826 ; aleksi@cesnet.cz.
authors.forename: Aleksi
authors.initials: A
authors.lastname: Sedo
authors.forename: Jarmila
authors.initials: J
authors.lastname: Stremenová
authors.forename: Petr
authors.initials: P
authors.lastname: Bušek
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Duke-Cohan