title: Endoglin (CD105) expression on microvessel endothelial cells in juvenile nasopharyngeal angiofibroma: tissue microarray analysis and association with prognostic significance.
abstract: BACKGROUND
  The purpose of this study was to examine endoglin (CD105) expression on microvessel endothelial cells (ECs) in juvenile nasopharyngeal angiofibroma (JNA) and its relationship with recurrence.
  
  
  METHODS
  Immunohistochemistry was performed to detect CD105 expression in a tissue microarray from 70 patients with JNA. Correlation between CD105 expression on microvessel ECs and clinicopathological features, as well as tumor recurrence, were analyzed.
  
  
  RESULTS
  Immunohistochemistry revealed CD105 expression on ECs but not in stroma of patients with JNA. Chi-square analysis indicated CD105-based microvessel density (MVD) was correlated with JNA recurrence (p = .013). Univariate and multivariate analyses determined that MVD was a significant predictor of time to recurrence (p = .009). The CD105-based MVD was better for predicting disease recurrence (AUROC: 0.673; p = .036) than other clinicopathological features.
  
  
  CONCLUSIONS
  MVD is a useful predictor for poor prognosis of patients with JNA after curative resection. Angiogenesis, which may play an important role in the occurrence and development of JNA, is therefore a potential therapeutic target for JNA.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Wang
authors.forename: Xi-Cai
authors.initials: XC
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Hu
authors.forename: Zhuo-Fu
authors.initials: ZF
authors.lastname: Liu
authors.forename: Hua-Peng
authors.initials: HP
authors.lastname: Yu
authors.forename: Han
authors.initials: H
authors.lastname: Li
authors.forename: Shu-Yi
authors.initials: SY
authors.lastname: Wang
authors.forename: De-Hui
authors.initials: DH
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D015703:Antigens, CD / Q000378:metabolism*; D002648:Child; D000071063:Endoglin; D042783:Endothelial Cells / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D055806:Microvessels / Q000166:cytology*; D015999:Multivariate Analysis; D009303:Nasopharyngeal Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D011379:Prognosis; D012372:ROC Curve; D011956:Receptors, Cell Surface / Q000378:metabolism*; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface
keywords: endoglin (CD105); immunohistochemistry; juvenile nasopharyngeal angiofibroma (JNA); microvessel density (MVD); tissue microarray (TMA)