title: Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain.
abstract: The generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neural progenitors survive for up to 6 months and differentiate into neurons, astrocytes, and myelinating oligodendrocytes in the brains of MPTP-induced hemiparkinsonian rhesus monkeys with a minimal presence of inflammatory cells and reactive glia. This finding represents a significant step toward personalized regenerative therapies.
authors.affiliation: Preclinical Parkinson's Research Program, Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.
authors.forename: Marina E
authors.initials: ME
authors.lastname: Emborg
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Jiajie
authors.initials: J
authors.lastname: Xi
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Zhang
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Yin
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Lu
authors.forename: Valerie
authors.initials: V
authors.lastname: Joers
authors.forename: Christine
authors.initials: C
authors.lastname: Swanson
authors.forename: James E
authors.initials: JE
authors.lastname: Holden
authors.forename: Su-Chun
authors.initials: SC
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology; D001921:Brain / Q000166:cytology* / Q000473:pathology; D002454:Cell Differentiation; D005260:Female; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000637:transplantation*; D020267:MPTP Poisoning / Q000628:therapy; D008253:Macaca mulatta; D058953:Neural Stem Cells / Q000166:cytology / Q000637:transplantation*; D009457:Neuroglia / Q000166:cytology; D009474:Neurons / Q000166:cytology; D009836:Oligodendroglia / Q000166:cytology