title: Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
abstract: Intestinal Peyer's patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin A (IgA) for gut homeostasis. Through the use of interleukin 17 (IL-17) fate-reporter mice, we found here that endogenous cells of the TH17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23. In Peyer's patches, such TH17 cells acquired a follicular helper T cell (TFH cell) phenotype and induced the development of IgA-producing germinal center B cells. Mice deficient in TH17 cells failed to generate antigen-specific IgA responses, which provides evidence that TH17 cells are the crucial subset required for the production of high-affinity T cell-dependent IgA.
authors.affiliation: Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, Mill Hill, London, UK.
authors.forename: Keiji
authors.initials: K
authors.lastname: Hirota
authors.forename: Jan-Eric
authors.initials: JE
authors.lastname: Turner
authors.forename: Matteo
authors.initials: M
authors.lastname: Villa
authors.forename: João H
authors.initials: JH
authors.lastname: Duarte
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Demengeot
authors.forename: Oliver M
authors.initials: OM
authors.lastname: Steinmetz
authors.forename: Brigitta
authors.initials: B
authors.lastname: Stockinger
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D005260:Female; D018858:Germinal Center / Q000166:cytology / Q000276:immunology; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000276:immunology*; D007071:Immunoglobulin A, Secretory / Q000276:immunology; D017578:Immunoglobulin Class Switching / Q000235:genetics / Q000276:immunology; D053759:Interleukin-23 / Q000235:genetics / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D053759:Interleukin-23