title: Identifying correlations between chromosomal proximity of genes and distance of their products in protein-protein interaction networks of yeast.
abstract: In this article we present evidence for a relationship between chromosome gene loci and the topological properties of the protein-protein interaction network corresponding to the set of genes under consideration. Specifically, for each chromosome of the Saccharomyces cerevisiae genome, the distribution of the intra-chromosome inter-gene distances was analyzed and a positive correlation with the distance among the corresponding proteins of the protein-protein interaction network was found. In order to study this relationship we used concepts based on non-parametric statistics and information theory. We provide statistical evidence that if two genes are closely located, then it is likely that their protein products are closely located in the protein-protein interaction network, or in other words, that they are involved in the same biological process.
authors.affiliation: Institute for System Analysis and Computer Science Antonio Ruberti, National Research Council of Italy, Rome, Italy. daniele.santoni@iasi.cnr.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Santoni
authors.forename: Filippo
authors.initials: F
authors.lastname: Castiglione
authors.forename: Paola
authors.initials: P
authors.lastname: Paci
mesh_terms: D020029:Base Pairing / Q000235:genetics; D002843:Chromatin / Q000378:metabolism; D015825:Chromosomes, Fungal / Q000235:genetics; D005800:Genes, Fungal / Q000235:genetics*; D060066:Protein Interaction Maps / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D002843:Chromatin; D029701:Saccharomyces cerevisiae Proteins