title: Aminoacyl-tRNA synthetase-interacting multi-functional protein 1/p43: an emerging therapeutic protein working at systems level.
abstract: BACKGROUND
  Drug discovery programs are based on the presumption of one drug-one action-one disease, which is frustrated by the complexity of biological systems. Because the aberration of a single gene often leads to multiple pathological symptoms, we should understand the functional network of the disease-related proteins to develop effective therapy.
  
  
  OBJECTIVE
  To describe how activities of proteins are reflected in phenotypes and their pathological implications using aminoacyl-tRNA synthetase-interacting multi-functional protein 1 (AIMP1).
  
  
  METHODS
  The physiological activities of AIMP1 are unveiled through in vitro approaches and in vivo phenotyptic investigation. Bioinformatics tool was used to combine all AIMP1-target proteins.
  
  
  CONCLUSIONS
  Although a cytosolic protein, AIMP1 can be secreted as a cytokine to control immune response, angiogenesis and wound healing, and as a glucagon-like hormone for glucose homeostasis. It is involved in the regulation of autoimmune control and TGF-β signaling within the cells. AIMP1-deficient mice developed multiple phenotypes in immune systems, metabolism and body growth. The therapeutic potential of this multi-functional protein with associated biological activities are discussed.
authors.affiliation: Seoul National University of Education, Department of Science and Technology Education for Life, 1650, Seocho-dong, Seocho-gu, Seoul 137-742, Korea.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Gyuyoup
authors.initials: G
authors.lastname: Kim
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Kim