title: Liver function tests in preeclampsia.
abstract: BACKGROUND
  Preeclampsia is a multisystem disorder that can induce damage to cardiovascular system, kidneys, brain and liver. Pregnancy-induced hypertension (PIH) is responsible for significant maternal and perinatal morbidity. This study was conducted to compare the liver function tests in preeclampsia with normal pregnancy.
  
  
  METHODS
  This study was carried out on 100 pregnant women after 20 weeks of gestation admitted in Obs/Gyn units of Ayub Teaching Hospital, Abbottabad. The subjects were divided into two groups. Group A consisted of 50 cases of preeclampsia having blood pressure > or = 140/90 mmHg, proteinuria in 24 hours > or = 300 mg and oedema; Group B had 50 normal pregnant women after 20 weeks of gestation. The data including BMI, parity, period of gestation, blood pressure and presenting complaints of all subjects were recorded. Serum bilirubin and plasma levels of liver enzymes ALT, AST and ALK were measured.
  
  
  RESULTS
  The mean BMI of the cases was 29.04 +/- 3.97 and that of controls was 26.54 +/- 3.11. The mean value of serum bilirubin in cases was 10.78 +/- 3.74 micromol/L and in controls it was 7.92 +/- 2.42 micromol/L (p < 0.001). The mean values of enzyme ALT in cases was 55.81 +/- 31.93 U/L while in the controls it was 15.22 +/- 3.30 U/L (p < 0.001). Mean serum AST in the cases was 41.34 +/- 10.76 U/L and in the controls it was 24 +/- 2.54 U/L (p < 0.001). Mean ALK level of cases before delivery was 454.16 +/- 243.69 U/L, and in controls it was 181.34 +/- 66.76 U/L (p < 0.001).
  
  
  CONCLUSIONS
  Raised levels of serum bilirubin and liver enzymes ALT, AST and ALK were found in preeclampsia cases.
authors.affiliation: Department of Physiology, Ayub Medical College, Abbottabad, Pakistan. drmunazzaqasim@gmail.com
authors.forename: Bibi
authors.initials: B
authors.lastname: Munazza
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Raza
authors.forename: Ayesha
authors.initials: A
authors.lastname: Naureen
authors.forename: Shahbaz Ali
authors.initials: SA
authors.lastname: Khan
authors.forename: Fozia
authors.initials: F
authors.lastname: Fatima
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ayub
authors.forename: Muhammad
authors.initials: M
authors.lastname: Sulaman
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy