title: An update on the clinical development of drugs to disable tumor vasculature.
abstract: Traditional methods of improving cancer therapy have focused primarily on achieving increased tumor cell kill. However, more recent strategies involve impairing the nutritional support system of the tumor by targeting the tumor vasculature. Rapid developments in this field in recent years have resulted in the identification of a variety of potential targets and a large number of investigational drugs, many of which are now in clinical development. In the following paper the authors review vascular disrupting therapies.
authors.affiliation: Professor and Associate Chair for Research, University of Florida, Department of Radiation Oncology, Shands Cancer Center, 2000 SW Archer Road, Gainesville, Fl 32610, USA +1 352 265 0287 ; +1 352 265 0759 ; siemadw@ufl.edu.
authors.forename: Dietmar W
authors.initials: DW
authors.lastname: Siemann
authors.forename: David J
authors.initials: DJ
authors.lastname: Chaplin