title: Rare neurological diseases: a practical approach to management.
abstract: Although neurologists are frequently faced with the management of rare diseases, there is little generic guidance for the approach to management. There are complexities with respect to diagnosis, counselling, treatment and monitoring which are idiosyncratic to rare diseases. Here we use a case report as the basis for discussion of the management of rare neurological diseases. We discuss current issues, guidance from regulatory bodies, and offer practical tips for diagnosis, treatment and monitoring, including the use of decision tree analysis. We offer a generic algorithm to aid neurologists when facing rare conditions.
authors.affiliation: Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK. krishna.dani@glasgow.ac.uk
authors.forename: Krishna A
authors.initials: KA
authors.lastname: Dani
authors.forename: Lesley J
authors.initials: LJ
authors.lastname: Murray
authors.forename: Saif
authors.initials: S
authors.lastname: Razvi
mesh_terms: D019468:Disease Management; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000628:therapy*; D020399:Practice Management; D015995:Prevalence; D035583:Rare Diseases / Q000175:diagnosis* / Q000628:therapy*
keywords: Diagnosis; Ethics; Medication; Rare Diseases; Superficial Siderosis