title: 18F-FDG PET/CT findings in voltage-gated potassium channel limbic encephalitis.
abstract: Limbic encephalitis (LE) can be associated with cancer, viral infection, or be idiopathic. One such rare but treatable form is associated with voltage-gated potassium channel (VGKC) antibodies. Typical abnormalities are seen in FDG PET/CT. We report a 39-year-old female patient who presented with 3 months of progressive faciobrachial dystonic seizures and limbic encephalitis. Her serum and cerebrospinal fluid Lgi1 antibody titers were elevated. FDG PET/CT showed basal ganglial hypermetabolism and associated abnormalities. Serial MRI demonstrated atrophic changes predominantly involving the temporal lobes. She is on immunosuppressive therapy and shows clinical improvement with lowering of antibody titers.
authors.affiliation: Kovai Medical Centre and Hospital, Coimbatore, India.
authors.forename: Koramadai Karuppuswamy
authors.initials: KK
authors.lastname: Kamaleshwaran
authors.forename: Rajesh Shankar
authors.initials: RS
authors.lastname: Iyer
authors.forename: Joppy
authors.initials: J
authors.lastname: Antony
authors.forename: Edathuruthy Kalarickal
authors.initials: EK
authors.lastname: Radhakrishnan
authors.forename: Ajit
authors.initials: A
authors.lastname: Shinto
mesh_terms: D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D020363:Limbic Encephalitis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D024642:Potassium Channels, Voltage-Gated / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D024642:Potassium Channels, Voltage-Gated; D019788:Fluorodeoxyglucose F18