title: Clinical trial of treatment programs for purulent vaginal discharge in lactating dairy cattle in New Zealand.
abstract: Studies of treatment of postpartum endometritis in dairy cows indicate that prostaglandin (PGF2α) might result in similar outcomes as intrauterine antibiotics, but the effect might depend on the presence of a CL. The objective was to compare reproductive performance in cows with purulent vaginal discharge treated on the basis of having or not having a CL (CL-dependent treatment; CLdep), versus treatment of all affected cows with an intrauterine antibiotic alone. Cows (N = 756) from 36 seasonal calving dairy herds in New Zealand were enrolled on the basis of having a vaginal discharge score (VDS) ≥2 (mucus with flecks of pus or more purulent) after examination with the Metricheck device (Simcro, Hamilton, New Zealand) and ≥14 days after calving. The presence of a CL was assessed by transrectal palpation. Cows were randomly assigned within farm to be treated with an intrauterine antibiotic (0.5 g cephapirin) irrespective of CL status, or treated with PGF2α if a CL was present and cephapirin if a CL was not present (CLdep). The VDS was reassessed 14 days later. Cows were bred using standard practices and pregnancy was tested to define the date of conception. The proportion of cows clinically cured (i.e., with a VDS ≤1 at reexamination) did not differ between treatment groups (0.82 ± 0.03 vs. 0.80 ± 0.03) for the group of cows treated with an intrauterine antibiotic irrespective of CL status and the CLdep groups, respectively (P = 0.66). The proportions of cows submitted for AI by 21 days into the breeding program, pregnant to first breeding, pregnant by 42 days into the breeding program, and at the end of the breeding program, and the interval from the start of the mating program to pregnancy did not differ among treatment groups. Cows that had positive VDS (i.e., >1) at Day 14 after treatment had lower proportions of conception and pregnancy than those with lower (<2) VDS. A treatment protocol in which cows with purulent vaginal discharge with a palpable CL were treated with PGF2α and those without a CL with intrauterine cephapirin resulted in reproductive performance that was not inferior to treating all cows with an intrauterine antibiotic.
authors.affiliation: Cognosco, Anexa Animal Health, Morrinsville, New Zealand. smcdougall@anexa.co.nz
authors.forename: Scott
authors.initials: S
authors.lastname: McDougall
authors.forename: Melvin
authors.initials: M
authors.lastname: de Boer
authors.forename: Chris
authors.initials: C
authors.lastname: Compton
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Leblanc
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002417:Cattle / Q000502:physiology; D002418:Cattle Diseases / Q000188:drug therapy*; D002514:Cephapirin / Q000008:administration & dosage* / Q000494:pharmacology; D003612:Dairying; D004716:Endometritis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary; D005260:Female; D007436:Intrauterine Devices, Medicated / Q000662:veterinary; D007774:Lactation / Q000187:drug effects / Q000502:physiology; D009520:New Zealand; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000662:veterinary*; D018873:Pregnancy Rate; D013492:Suppuration / Q000150:complications / Q000188:drug therapy* / Q000662:veterinary; D019522:Vaginal Discharge / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D016585:Vaginosis, Bacterial / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents; D002514:Cephapirin