title: microRNA aberrations in Waldenström macroglobulinemia.
abstract: Waldenström macroglobulinemia (WM) is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the BM (BM) and monoclonal immunoglobulin M in the circulation. Although WM cells showed minimal changes in cytogenetic studies and gene expression analysis, primary WM tumor cells present with a micro-RNA (miRNA) signature that differentiates them from their normal counterparts. This may suggest the importance of miRNAs in supporting WM pathogenesis. Among deregulated miRNAs, miRNA-155 has been shown to play a pivotal role in the biological characteristics of this disease both in vitro and in vivo, thus providing the rationale for testing miRNA-based therapeutic approaches for the treatment of WM.
authors.affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sacco
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Patricia
authors.initials: P
authors.lastname: Maiso
authors.forename: Salomon
authors.initials: S
authors.lastname: Manier
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rossi
authors.forename: Steven P
authors.initials: SP
authors.lastname: Treon
authors.forename: Irene M
authors.initials: IM
authors.lastname: Ghobrial
authors.forename: Aldo M
authors.initials: AM
authors.lastname: Roccaro
mesh_terms: D002869:Chromosome Aberrations; D015870:Gene Expression; D005786:Gene Expression Regulation; D055785:Gene Knockdown Techniques; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics*
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs