title: Adaptive and maladaptive responses in skin: mild heat exposure protects against UVB-induced photoaging in mice.
abstract: In this issue, Matsuda et al. demonstrate the protective effect of mild heat preconditioning on UVB-induced photoaging in SKH-1 hairless mice. Mild heat exposure stimulates the upregulation of HSP70 chaperones, which inhibit the activities of matrix-degenerating enzymes, thereby avoiding wrinkle formation. This newly identified heat-mediated process of adaptation to UVB radiation exposure opens new opportunities to slow extrinsic skin aging.
authors.affiliation: IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Haarmann-Stemmann
authors.forename: Fritz
authors.initials: F
authors.lastname: Boege
authors.forename: Jean
authors.initials: J
authors.lastname: Krutmann
mesh_terms: D000818:Animals; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D018869:Heat-Shock Response / Q000502:physiology*; D051379:Mice; D015595:Skin Aging / Q000235:genetics* / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D018840:HSP70 Heat-Shock Proteins