title: Plasma N-terminal pro-brain natriuretic peptide levels are positively correlated with pulmonary arterial pressure in atrial septal defect patients.
abstract: N-terminal pro-brain natriuretic peptide (NT-proBNP), a pro-hormone secreted by the myocardium in response to various stimuli, was found to be correlated with several hemodynamic parameters in pulmonary hypertension associated with systemic sclerosis. We investigated plasma NT-proBNP levels and the relationships between NT-proBNP and several hemodynamic parameters in atrial septal defect (ASD) patients with or without pulmonary arterial hypertension (PAH). We found that plasma NT-proBNP level was significantly higher in PAH group compared with the control group (5495.4±388.4 pg/ml vs 4005.1±260.5 pg/ml, P<0.05). In a multiple regression model analysis, only mean pulmonary arterial pressure was an independent predictor of NT-proBNP (standardized coefficient=0.663, P=0.002). In the PAH group, only right atrial systolic pressure was found to be positively correlated with NT-proBNP, whereas other parameters were not found to be correlated with NT-proBNP. Our data suggests that NT-proBNP might also be a predictor of the severity of pulmonary hypertension in the ASD patients.
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Department of Cardiology, No. 88 Hospital of PLA, Tai'an City, Shandong Province, 271000, China.
authors.forename: Zhao-Feng
authors.initials: ZF
authors.lastname: Li
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Da-Xin
authors.initials: DX
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Qi-Bing
authors.initials: QB
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Wen-Zhi
authors.initials: WZ
authors.lastname: Pan
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. Electronic address: jbge@zs-hospital.sh.cn.
authors.forename: Jun-Bo
authors.initials: JB
authors.lastname: Ge
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000097:blood* / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain