title: Foreign body reaction to Radiesse: 2 cases.
abstract: We report 2 cases of a foreign body reaction to Radiesse, a semipermanent soft-tissue filler consisting of 30% calcium hydroxylapatite microspheres and 70% carboxymethyl cellulose gel carrier. In one case, injection of this filler provoked a nodule on the columella, which was discovered during rhinoplasty. In the second case, the reaction was revealed during histopathologic examination of the deep section of a surgically removed basal-cell carcinoma. Histopathology showed a foreign body reaction with numerous giant cells and histiocytes, some plasma cells, and lymphocytes. Within this inflammatory reaction, a nonpolarizing exogenous material was identified consisting of numerous, round, uniformly sized, yellowish, extracellular deposits with a crackled appearance. Although many authors claim that Radiesse does not induce any foreign body reactions, we found a number of similar histopathologic pictures in studies describing animal or human auricular area test sites or even in reports of lip nodules, which are a well-known adverse effect after injection of this filler into this site. The histopathologic appearance of Radiesse is particularly distinctive and easily recognizable by dermatologists and dermatopathologists.
authors.affiliation: Cabinet de Dermatopathologie, Paris, France. imoulonguetmichau@gmail.com
authors.forename: Isabelle
authors.initials: I
authors.lastname: Moulonguet
authors.forename: Eric
authors.initials: E
authors.lastname: Arnaud
authors.forename: Patrick
authors.initials: P
authors.lastname: Bui
authors.forename: Françoise
authors.initials: F
authors.lastname: Plantier
mesh_terms: D000328:Adult; D001672:Biocompatible Materials; D001706:Biopsy; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000009:adverse effects*; D003357:Cosmetic Techniques / Q000009:adverse effects*; D017886:Durapatite / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005549:Foreign-Body Reaction / Q000139:chemically induced* / Q000473:pathology; D005782:Gels; D006801:Humans; D033162:Incidental Findings; D007267:Injections; D008875:Middle Aged; D061214:Patient Safety; D012307:Risk Factors
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D017886:Durapatite; D002266:Carboxymethylcellulose Sodium