title: The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells.
abstract: OBJECTIVE
  Cheongseoikki-tang (CIT, Korean), also called Qingshu Yiqi decoction () and Seisho-ekki-to (Japanese), is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms.
  
  
  METHODS
  In this study, the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated BMMCs. These allergic mediators included interleukin-6 (IL-6), prostaglandin D2 (PGD2), leukotriene C4 (LTC4), and β-hexosaminidase (β-hex).
  
  
  RESULTS
  Our data revealed that CITE inhibited the production of IL-6, PGD2, LTC4, and β-hex induced by PMA plus A23187 (P<0.05).
  
  
  CONCLUSIONS
  These findings indicate that CITE has the potential for use in the treatment of allergy.
authors.affiliation: College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University, Jeonbuk 570-749, Republic of Korea.
authors.forename: Joon-Ho
authors.initials: JH
authors.lastname: Keum
authors.forename: Ok-Hwa
authors.initials: OH
authors.lastname: Kang
authors.forename: Sung-Bae
authors.initials: SB
authors.lastname: Kim
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Mun
authors.forename: Yun-Soo
authors.initials: YS
authors.lastname: Seo
authors.forename: Ma-Ryong
authors.initials: MR
authors.lastname: Kim
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
authors.forename: Young-Seob
authors.initials: YS
authors.lastname: Lee
authors.forename: Chung-Berm
authors.initials: CB
authors.lastname: Park
authors.forename: Young-Guk
authors.initials: YG
authors.lastname: Kim
authors.forename: Yong-Il
authors.initials: YI
authors.lastname: Kim
authors.forename: Sin-Hee
authors.initials: SH
authors.lastname: Han
authors.forename: Dong-Yeul
authors.initials: DY
authors.lastname: Kwon
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001854:Bone Marrow Cells / Q000473:pathology*; D000001:Calcimycin / Q000494:pharmacology; D015550:Cell Degranulation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006967:Hypersensitivity / Q000188:drug therapy* / Q000473:pathology; D015850:Interleukin-6 / Q000378:metabolism; D017997:Leukotriene C4 / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000473:pathology* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D015230:Prostaglandin D2 / Q000096:biosynthesis; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; C588018:cheongseoikki-tang; D017997:Leukotriene C4; D000001:Calcimycin; D001619:beta-N-Acetylhexosaminidases; D013755:Tetradecanoylphorbol Acetate; D015230:Prostaglandin D2