title: [Activation of lipid peroxidation in patients with renal hypertension].
abstract: The study involved 53 patients with arterial hypertension in chronic kidney disease (chronic glomerulonephritis (CGN)). Lipid peroxidation was studied based on the content of diene conjugates and malondialdehyde. Protein peroxidation was studied based on the content of 2,4-dinitphenyl-aldogidrazons. The patients in all clinical variants of the CGN revealed increased activity of lipid peroxidation and the protein peroxidation, which is most pronounced in patients with nephrotic variant of CGN: increased levels of serum malondialdehyde medians occurred in 3.92 times and diene conjugates in 1.52 times (p<0.01). Increased activity of the oxidation of lipids and proteins has a negative impact on the organization of cell membranes of the renal structures and leads to loss of membrane barrier function.
authors.affiliation: Sumy State University, Ukraine.
authors.forename: N
authors.initials: N
authors.lastname: Demikhova
authors.forename: V
authors.initials: V
authors.lastname: Sukhonos
authors.forename: L
authors.initials: L
authors.lastname: Vynnychenko
authors.forename: V
authors.initials: V
authors.lastname: Psareva
authors.forename: O
authors.initials: O
authors.lastname: Prikhodko
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications / Q000473:pathology; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood* / Q000150:complications / Q000235:genetics / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000473:pathology; D015227:Lipid Peroxidation / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction
chemical_list: D008055:Lipids; D008315:Malondialdehyde