title: Soy milk consumption and blood pressure among type 2 diabetic patients with nephropathy.
abstract: OBJECTIVE
  The purpose of this study was to determine the effects of soy milk consumption cardiovascular risk and biomarkers of renal function in type 2 diabetic patients with nephropathy.
  
  
  METHODS
  This randomized, crossover, controlled clinical trial was conducted in 29 type 2 diabetic patients with nephropathy. Participants were randomly assigned to consume a diet containing soy milk, or a diet containing cow's milk, each for 4 weeks. There was a 2-week washout between the two intervention periods. Anthropometric and biochemical measurements were performed according to standard protocols.
  
  
  RESULTS
  The mean age and body mass index of patients were 51 ± 10 years and 28 ± 4 kg/m(2), respectively. Consumption of soy milk resulted in a significant reduction in systolic blood pressure compared with consumption of cow's milk (percent change: -4.50 vs. 5.89%; P = .03). Serum triglyceride levels decreased significantly after soy milk consumption (percent change: -15.22 vs. 2.37%; P = .02). After adjustment for carbohydrate intake, the effect of soy milk on triglyceride level was not significant. There were no significant differences between soy milk and cow's milk consumption in terms of their effect on cardiovascular risks and markers of kidney function.
  
  
  CONCLUSIONS
  Soy milk consumption was associated with better blood pressure control among diabetic patients with nephropathy.
authors.affiliation: Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Maryam Sadat
authors.initials: MS
authors.lastname: Miraghajani
authors.forename: Mojgan Mortazavi
authors.initials: MM
authors.lastname: Najafabadi
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Surkan
authors.forename: Ahmad
authors.initials: A
authors.lastname: Esmaillzadeh
authors.forename: Maryam
authors.initials: M
authors.lastname: Mirlohi
authors.forename: Leila
authors.initials: L
authors.lastname: Azadbakht
mesh_terms: D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications; D002784:Cholesterol / Q000097:blood; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D004032:Diet; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D008892:Milk; D012307:Risk Factors; D041942:Soy Milk / Q000008:administration & dosage*; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D002784:Cholesterol