title: Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors.
abstract: Meta-iodobenzylguanidine (MIBG), an analog of the adrenergic neurotransmitter norepinephrine, has proven a valuable imaging agent for neuroendocrine and neural crest tumors. Over the past 3 decades, MIBG labeled with [131I] or [123I] has been used widely in imaging of neuroblastoma and pheochromocytoma. Before September 2008 [131I]MIBG was approved as a diagnostic agent only in the US. Due to the excellent physical characteristics of [123I] for imaging with modern scintillation cameras, [123I]MIBG is theoretically more suitable than [131I]MIBG in detecting tumors. In practice, use of [123I]MIBG or [131I]MIBG for diagnostic studies depends on availability and local preference. This review compares [123I]MIBG with [131I]MIBG in imaging of neuroblastoma and other neural crest tumors and also the physical properties of relevant radioisotopes. Dosimetry and scanning protocols of [123I]MIBG and [131I]MIBG, along with their value in depicting disease extent, assessing treatment response and predicting survival are also compared. The performance of post-therapy high-activity [131I]MIBG scans in lesion detectability is also addressed.
authors.affiliation: Department of Nuclear Medicine, West China Hospital Sichuan University, Chengdu, Sichuan, China.
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Zhuang
authors.forename: S
authors.initials: S
authors.lastname: Servaes
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002648:Child; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D009447:Neuroblastoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011874:Radiometry / Q000379:methods; D013997:Time Factors; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D051598:Whole Body Imaging / Q000379:methods
chemical_list: D007457:Iodine Radioisotopes; D019797:3-Iodobenzylguanidine