title: [Characterization of influenza virus reassortants based on new donor strain A/HK/1/68/162/35(H3N2)].
abstract: Influenza reassortant viruses A/SPb/HK/09(H1N1), A/Astana/HK/2009 (H5N1), A/Otar/HK/2010(H3N8), and A/Perth/ HK/2011(H3N2), carrying surface antigens of different subtypes, were constructed on the basis of new potential unified donor strain A/HK/1/68/162/35(H3N2). The virulence and reproduction activity of the obtained reassortants were tested. The safety of the candidate live and inactivated influenza vaccines produced from the reassortant viruses was demonstrated. The study demonstrates that A/HK/1/68/162/35 can be used as a unified donor for attenuated and high-yield vaccine reassortants.
authors.forename: M V
authors.initials: MV
authors.lastname: Potapchuk
authors.forename: I A
authors.initials: IA
authors.lastname: Repko
authors.forename: M V
authors.initials: MV
authors.lastname: Sergeeva
authors.forename: A V
authors.initials: AV
authors.lastname: Korotkov
authors.forename: A B
authors.initials: AB
authors.lastname: Komissarov
authors.forename: N T
authors.initials: NT
authors.lastname: Sandybaev
authors.forename: O V
authors.initials: OV
authors.lastname: Cherviakova
authors.forename: V M
authors.initials: VM
authors.lastname: Khaĭrullin
authors.forename: L M
authors.initials: LM
authors.lastname: Tsybalova
mesh_terms: D000818:Animals; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D053123:Influenza A Virus, H3N8 Subtype / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D007252:Influenza Vaccines / Q000235:genetics; D007251:Influenza, Human / Q000235:genetics / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D051379:Mice; D014613:Vaccines, Attenuated / Q000235:genetics / Q000276:immunology; D015164:Vaccines, Inactivated / Q000235:genetics / Q000276:immunology; D014779:Virus Replication / Q000235:genetics
chemical_list: D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated