title: Aiming for the outliers: cancer precision medicine through targeting kinases with extreme expression.
abstract: With the increasing availability of highly potent, pharmacologically active, and selective protein kinase inhibitors, identification of individuals who would benefit from targeted kinase inhibitors could facilitate application of precision medicine strategies for cancer therapy. A recent study by Kothari and colleagues reports preclinical studies that highlight the potential of targeting kinases with extreme expression for cancer precision medicine, warranting further clinical investigation of an individual-specific outlier kinase targeting approach.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center, The Sol Golman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21231, USA. syegnasu@jhmi.edu
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Yegnasubramanian
authors.forename: Anirban
authors.initials: A
authors.lastname: Maitra
mesh_terms: D000818:Animals; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011494:Protein Kinases / Q000096:biosynthesis*; D017423:Sequence Analysis, RNA / Q000379:methods*
chemical_list: D047428:Protein Kinase Inhibitors; D011494:Protein Kinases