title: Preparation and optical property of new fluorescent nanoparticles.
abstract: A new fluorescent nanoparticle (PIOT-HA) is synthesized with cationic polyester (PIOT) and anionic hyaluronic acid (HA) by electrostatic interactions in an aqueous solution. The nanoparticles (NPs) are degradable upon treatments with alkali or hyaluronidase, which exhibits better biological safety and potential application in vitro and in vivo. Through specific interactions between the HA locating on the surfaces of PIOT-HA NPs and the CD44 protein over-expressed on the MDA-MB-231 cancer cell line, PIOT-HA NPs could selectively image the cancer cells. Upon white light irradiation, the PIOT-HA NPs can sensitize oxygen to generate reactive oxygen species (ROS) that inactivate the neighboring CD44 protein, which inhibits the migration of MDA-MB-231 cancer cells.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chong
authors.forename: Chunlei
authors.initials: C
authors.lastname: Zhu
authors.forename: Jinzhao
authors.initials: J
authors.lastname: Song
authors.forename: Liheng
authors.initials: L
authors.lastname: Feng
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.forename: Libing
authors.initials: L
authors.lastname: Liu
authors.forename: Fengting
authors.initials: F
authors.lastname: Lv
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
mesh_terms: D015374:Biosensing Techniques; D045744:Cell Line, Tumor; D002465:Cell Movement; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D006820:Hyaluronic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D009904:Optical Rotation; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D018960:Hyaluronan Receptors; D011091:Polyesters; D017382:Reactive Oxygen Species; D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase