title: Chemotherapy-related cardiotoxicity.
abstract: Cardiovascular toxicity caused by cancer therapy is a challenging area which needs thorough evaluation and research. Numerous studies, meta-analyses and reviews have been published in the past discussing cardiotoxicity caused by chemotherapeutic agents. A brief review of the on-target and off-target cardiotoxicities caused by chemotherapeutic agents is presented here. Cardiotoxicities are broadly outlined in terms of left ventricular dysfunction, hypertension and thromboembolic events. The mechanisms leading to the cardiotoxicity profiles of various chemotherapeutic agents are discussed. The management of various cardiotoxicities of chemotherapeutic agents is also discussed.
authors.affiliation: Department of Medicine, Chicago Medical School/Rosalind Franklin University, 3333, Green Bay Road, North Chicago, IL 60064, USA. drsaurabhaggarwal@ gmail.com
authors.forename: Saurabh
authors.initials: S
authors.lastname: Aggarwal
authors.forename: Jasmine
authors.initials: J
authors.lastname: Kamboj
authors.forename: Rohit
authors.initials: R
authors.lastname: Arora
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D011379:Prognosis; D012307:Risk Factors; D013923:Thromboembolism / Q000139:chemically induced; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents