title: Targeting PI3Kδ: One man's meat is another man's poison.
abstract: We have recently uncovered the indispensable role of phosphoinositide-3-kinase δ (PI3Kδ) at different stages of the canonical killing pathway of cytotoxic T lymphocytes (CTLs). The interception of PI3Kδ-conveyed signals has been considered a valuable therapeutic strategy in oncology. However, our observations predict that the benefits of this approach may be limited by a trade-off between direct anticancer effects and an impaired ability of CTLs and NK cells to attack tumor cells.
authors.affiliation: Institute of Pharmacology and Toxicology; Department for Biomedical Science; University of Veterinary Medicine Vienna; Vienna, Austria.
authors.forename: Michaela
authors.initials: M
authors.lastname: Prchal-Murphy
authors.forename: Eva Maria
authors.initials: EM
authors.lastname: Putz
authors.forename: Michael
authors.initials: M
authors.lastname: Freissmuth
authors.forename: Veronika
authors.initials: V
authors.lastname: Sexl
authors.forename: Eva
authors.initials: E
authors.lastname: Zebedin-Brandl
keywords: cytotoxic T lymphocytes (CTLs); natural killer (NK) cells; signal-interception based therapy; tumor immunosurveillance