title: The role of platelet serotonin and depression in the acute coronary syndrome population.
abstract: Platelet serotonin has been associated with depression and coronary artery disease. Understanding the association between platelet serotonin and depressive symptoms during acute coronary syndrome (ACS) may explain some of the ACS events seen in depressed individuals. The objectives were to evaluate whether levels of platelet serotonin during an ACS event differ between individuals who screen positive or negative for depressive symptoms and to determine if a linear relationship exists. In this cross-sectional study, data were collected on 51 patients with ACS. Multiple linear regression models were examined. Platelet serotonin levels were not significantly different between the depressed and non-depressed groups (β = -4.093 and p = .293); a linear relationship was not found (β = -.254 and p = .250). In conclusion, a relationship between platelet serotonin and depressive symptoms was not found. It remains unclear if an association exists between platelet serotonin levels and depressive symptoms during hospitalization for ACS.
authors.affiliation: The University of Texas Health Science Center at Houston School of Nursing, Houston, Texas 77030, USA. jennifer.e.sanner@uth.tmc.edu
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Sanner
authors.forename: Lorraine
authors.initials: L
authors.lastname: Frazier
authors.forename: Malini
authors.initials: M
authors.lastname: Udtha
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000523:psychology; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003863:Depression / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000097:blood*
chemical_list: D012701:Serotonin
keywords: acute coronary syndrome; cardiovascular; depression; platelet serotonin; serotonin