title: Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation.
abstract: A spectrum of kidney diseases besides classic human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) exists in HIV-infected patients. Immune complex-mediated glomerulonephritis has emerged as a significant contributor to the burden of kidney disease in this population, particularly in patients of non-African descent. Lupus-like nephritis, a form of immune complex glomerulonephritis with histologic features identical to lupus nephritis in the absence of clinical or serologic markers of lupus, is well recognized as a cause of end-stage renal disease in HIV-infected patients. None of the HIV-associated kidney lesions, whether classic HIVAN or non-HIVAN, has been reported to recur in kidney transplants. We report here for the first time clinical and histologic recurrence of HIV-associated lupus-like nephritis after successful kidney transplantation, causing proteinuria, hematuria, and impaired kidney transplant function.
authors.affiliation: Department of Medicine-Kidney Transplant Unit, University of California, San Francisco, San Francisco, CA, USA. sindhu.chandran@ucsf.edu
authors.forename: Sindhu
authors.initials: S
authors.lastname: Chandran
authors.forename: Kuang-Yu
authors.initials: KY
authors.lastname: Jen
authors.forename: Zoltan G
authors.initials: ZG
authors.lastname: Laszik
mesh_terms: D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis / Q000276:immunology / Q000601:surgery* / Q000821:virology*; D015658:HIV Infections; D006801:Humans; D007105:Immune Complex Diseases / Q000175:diagnosis / Q000601:surgery* / Q000821:virology*; D016030:Kidney Transplantation; D008181:Lupus Nephritis; D012008:Recurrence
keywords: Human immunodeficiency virus (HIV); kidney transplantation; lupus nephritis; recurrent disease; recurrent glomerulonephritis