title: A new pyrrole synthesis via silver(I)-catalyzed cycloaddition of vinylogous diazoester and nitrile.
abstract: A new synthesis of di- and trisubstituted pyrroles was achieved by treating in situ generated vinylogous diazoesters and readily available nitriles with a catalytic amount of silver(I) antimony hexafluoride at room temperature. This method showcased the potential of utilizing silver(I) carbenoids in preparing heterocyclic compounds.
authors.affiliation: Hoffmann-La Roche Inc., pRED, Pharma Research & Early Development, Small Molecule Research, Discovery Chemistry, 340 Kingsland Street, Nutley, New Jersey 07110, United States.
authors.forename: Roland J
authors.initials: RJ
authors.lastname: Billedeau
authors.forename: Klara R
authors.initials: KR
authors.lastname: Klein
authors.forename: Daniel
authors.initials: D
authors.lastname: Kaplan
authors.forename: Yan
authors.initials: Y
authors.lastname: Lou
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D012834:Silver / Q000737:chemistry*
chemical_list: D009570:Nitriles; D011758:Pyrroles; D012834:Silver