title: Humoral mechanisms regulating the functions of progenitor cells in chronic hepatitis.
abstract: We studied the secretory function of the liver and bone marrow microenvironment cells under conditions of chronic CCl4-induced hepatitis. Enhanced production of substances stimulating parenchymal tissue-specific precursors and stem cell homing factors by liver cells was observed. In situ binding of stem cells by bone marrow elements increased due to production of various cooperation and adhesion factors against the background of reduced SDF-1 secretion.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: R V
authors.initials: RV
authors.lastname: Gurto
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskiy
authors.forename: T S
authors.initials: TS
authors.lastname: Markova
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism*; D002251:Carbon Tetrachloride; D002465:Cell Movement; D060833:Cellular Microenvironment; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000378:metabolism / Q000473:pathology*; D054377:Chemokine CXCL12 / Q000378:metabolism; D017077:Culture Media, Conditioned / Q000737:chemistry; D006521:Hepatitis, Chronic / Q000378:metabolism / Q000473:pathology*; D008099:Liver / Q000166:cytology* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D055153:Stem Cell Niche; D013234:Stem Cells / Q000502:physiology*
chemical_list: D054377:Chemokine CXCL12; D017077:Culture Media, Conditioned; C515256:Cxcl12 protein, mouse; D002251:Carbon Tetrachloride