title: Serological evidence indicates that foot-and-mouth disease virus serotype O, C and SAT1 are most dominant in eritrea.
abstract: Foot-and-mouth disease (FMD) is endemic in Eritrea and in most parts of Africa. To be able to control FMD using vaccination, information on the occurrence of various foot-and-mouth disease serotypes in Eritrea is needed. In this cross-sectional study, 212 sera samples were collected from FMD infected and recovered animals in Eritrea. These samples were tested for the presence of antibodies against FMD non-structural proteins (NSP) and neutralizing antibodies against six of the seven (all but SAT 3) serotypes of FMD virus (FMDV). Of these, 67.0% tested positive to non-structural protein antibodies in the FMD NS ELISA. By virus neutralization, FMDV serotype O antibodies were shown to be the most dominant (approximately 50%). Virus neutralization test results indicate that infection with serotype C and SAT 1 might have occurred, although there are no reports of isolation of these two serotypes. Because the samples were not randomly selected, further random serological surveillance in all age group animals is necessary both to estimate the prevalence of FMD in the country and to confirm the serological results with serotype C and SAT 1.
authors.affiliation: Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands; National Veterinary Laboratory, Ministry of Agriculture, Asmara, Eritrea.
authors.forename: T
authors.initials: T
authors.lastname: Tekleghiorghis
authors.forename: R J M
authors.initials: RJ
authors.lastname: Moormann
authors.forename: K
authors.initials: K
authors.lastname: Weerdmeester
authors.forename: A
authors.initials: A
authors.lastname: Dekker
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral / Q000097:blood*; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods / Q000662:veterinary; D019017:Eritrea / Q000453:epidemiology; D005536:Foot-and-Mouth Disease / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D065288:Serogroup
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral
keywords: NS ELISA; foot-and-mouth disease virus; serotype; surveillance; validation; virus neutralization test