title: Strength of Coupling within a mnemonic control network differentiates those who can and cannot suppress memory retrieval.
abstract: The ability to direct our thought processes influences not only what we do, but also what we remember later. Here we sought to identify the brain network that supports the ability to control memory retrieval and to understand the neural basis of age-related changes and individual differences in the capacity for mnemonic control. To this end, we collected functional MRI data from 43 children and young adults while they attempted to retrieve or suppress retrieval of previously learned associations. Seed-based functional connectivity analyses revealed a largely right-lateralized dorsolateral prefrontal cortex-cingulate-parietal-hippocampal network that exhibited strongly correlated activity during retrieval suppression. Regardless of age, individuals who were able to suppress memory retrieval exhibited tighter coupling between key nodes in this dorsolateral prefrontal cortex-cingulate-parietal-hippocampal network than individuals who did not. Further, only those capable of mnemonic control exhibited tighter coupling during successful retrieval suppression (intentional forgetting) than during unsuccessful retrieval (unintentional forgetting). Across both children and adults, individual differences in retrieval suppression were best explained by the strength of these network interactions.
authors.affiliation: Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA. p.pazalonso@bcbl.eu
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Paz-Alonso
authors.forename: Silvia A
authors.initials: SA
authors.lastname: Bunge
authors.forename: Michael C
authors.initials: MC
authors.lastname: Anderson
authors.forename: Simona
authors.initials: S
authors.lastname: Ghetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D000704:Analysis of Variance; D001245:Association Learning / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000254:growth & development / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009434:Neural Pathways / Q000098:blood supply / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D012094:Repression, Psychology; D013850:Thinking / Q000502:physiology; D014825:Vocabulary; D055815:Young Adult
chemical_list: D010100:Oxygen