title: Comparison of new and established full-field digital mammography systems in diagnostic performance.
abstract: OBJECTIVE
  To compare the diagnostic performance of new and established full-field digital mammography (FFDM) systems.
  
  
  METHODS
  During a 15-month period, 1038 asymptomatic women who visited for mammography were prospectively included from two institutions. For women with routine two-view mammograms from established FFDM systems, bilateral mediolateral oblique (MLO) mammograms were repeated using the new FFDM system. One of the four reviewers evaluated two-sets of bilateral MLO mammograms at 4-week intervals by using a five-point score for the probability of malignancy according to a Breast Imaging Reporting and Data System. The lesion type and breast density were determined by the consensus of two readers at each institution. The dichotomized mammographic results correlated with a final pathologic outcome and follow-up data. Receiver operating characteristic (ROC) curves, sensitivity, and specificity were compared in general and according to the lesion type and breast density.
  
  
  RESULTS
  Of the 1038 cases, 193 (18.6%) had cancer. The areas under the ROC curve (AUC), sensitivity, and specificity of the established system were 0.815, 65.3%, and 90.2%, respectively. Those of the new system were 0.839, 68.4%, and 91.7%, respectively. There were no significant differences in the AUCs, sensitivities or the specificities in general between new and established systems (Ps = 0.194, 0.590, 0.322, respectively). We found no significant difference in these parameters according to lesion type or breast density.
  
  
  CONCLUSIONS
  The new FFDM system has a comparable diagnostic performance with established systems.
authors.affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Ko
authors.forename: Boo-Kyung
authors.initials: BK
authors.lastname: Han
authors.forename: Sun Mi
authors.initials: SM
authors.lastname: Kim
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Ko
authors.forename: Mijung
authors.initials: M
authors.lastname: Jang
authors.forename: Chae Yeon
authors.initials: CY
authors.lastname: Lyou
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Chang
authors.forename: Woo Kyung
authors.initials: WK
authors.lastname: Moon
authors.forename: Rock Bum
authors.initials: RB
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D011856:Radiographic Image Enhancement / Q000379:methods*; D056910:Republic of Korea; D012680:Sensitivity and Specificity
keywords: Analysis; Breast; Comparison; Digital mammography; FFDM