title: Clinical and cognitive correlations of regional gray matter atrophy in progressive supranuclear palsy.
abstract: BACKGROUND
  Progressive supranuclear palsy is the most common neurodegenerative bradykinetic-rigid syndrome after Parkinson's disease. Several volumetric studies have revealed a widespread cortical and subcortical gray matter atrophy, however the correlations between the pattern of gray matter loss and clinical-cognitive features have been poorly investigated.
  
  
  METHODS
  By using 3-T magnetic-resonance imaging and voxel-based morphometry we compared gray matter volume in 15 patients with progressive supranuclear palsy, 15 patients with Parkinson's disease and 15 healthy controls. All patients underwent a clinical and neuropsychological evaluation.
  
  
  RESULTS
  In agreement with previous studies, patients with progressive supranuclear palsy, compared to patients with Parkinson's disease and healthy controls, showed a reduced gray matter volume in several cortical and subcortical areas including cerebellum, frontal, temporal and parahippocampal cortical structures. We did not find any significant gray matter volume changes when comparing patients with Parkinson's disease vs healthy controls. Among different significant correlations between motor-cognitive features and gray matter loss, we detected a significant correlation between fronto-cerebellar gray matter atrophy and executive cognitive impairment in patients with progressive supranuclear palsy.
  
  
  CONCLUSIONS
  Our findings confirm that gray matter loss in patients with progressive supranuclear palsy involves several brain areas and suggest that cerebellar atrophy may play a role in the pathogenesis of cognitive dysfunction in patients with progressive supranuclear palsy due to a disruption of its modulation on executive functions.
authors.affiliation: Department of Neurology, Second University of Naples, Piazza Miraglia, 2, 80100 Naples, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Giordano
authors.forename: Alessandro
authors.initials: A
authors.lastname: Tessitore
authors.forename: Daniele
authors.initials: D
authors.lastname: Corbo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cirillo
authors.forename: Rosa
authors.initials: R
authors.lastname: de Micco
authors.forename: Antonio
authors.initials: A
authors.lastname: Russo
authors.forename: Sara
authors.initials: S
authors.lastname: Liguori
authors.forename: Mario
authors.initials: M
authors.lastname: Cirillo
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Esposito
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Tedeschi
mesh_terms: D000368:Aged; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013494:Supranuclear Palsy, Progressive / Q000150:complications* / Q000473:pathology*