title: A histopathological and immunohistochemical analysis of ameloblastic fibrodentinoma.
abstract: Ameloblastic fibrodentinoma (AFD) is considered a mixed odontogenic tumor that is characterized by conserved epithelial and ectomesenchymal neoplastic components. AFD is composed of long narrow cords and islands of odontogenic epithelium; the epithelial strands lie in a myxoid cell-rich ectomesenchymal tissue with stellate-shaped fibroblasts that exhibit long slender cytoplasmic extensions that resemble dental papilla. The lesions show the presence of dysplastic dentin. Although AFD is a rare entity and its very existence is not completely accepted, based on the extent of histodifferentiation, it is considered to represent a stage between ameloblastic fibroma and ameloblastic fibroodontoma. This study aimed to provide a histopathological and immunohistochemical characterization of this infrequent tumor. A large panel of antibodies including amelogenin, Ck 19, calretinin, syndecan-1, E-cadherin, MSH2, histone H3, and Ki-67 was used to illustrate the nature of the tumor.
authors.affiliation: Oral Pathology, Research Department, School of Dentistry, Universidad Juárez del Estado de Durango (UJED), 34000 Durango, DGO, Mexico ; School of Dentistry, Universidad de la República (UDELAR), 19200 Montevideo, Uruguay.
authors.forename: Ronell
authors.initials: R
authors.lastname: Bologna-Molina
authors.forename: Sirced
authors.initials: S
authors.lastname: Salazar-Rodríguez
authors.forename: Ana María
authors.initials: AM
authors.lastname: Bedoya-Borella
authors.forename: Ramón Gil
authors.initials: RG
authors.lastname: Carreón-Burciaga
authors.forename: Gabriel
authors.initials: G
authors.lastname: Tapia-Repetto
authors.forename: Nelly
authors.initials: N
authors.lastname: Molina-Frechero