title: Predictive value of circulating interleukin-6 and heart-type fatty acid binding protein for three months clinical outcome in acute cerebral infarction: multiple blood markers profiling study.
abstract: BACKGROUND
  There is no single blood marker for predicting the prognosis in ischemic stroke. A combination of multiple blood markers may enhance the ability to predict long-term outcome following ischemic stroke.
  
  
  METHODS
  Blood concentrations of neuronal markers (neuron-specific enolase, visinin-like protein 1, heart type fatty acid binding protein (hFABP) and neuroglobin), astroglial markers (S100B and glial fibrillary acidic protein), inflammatory markers (IL-6, TNF-α, and C-reactive protein), blood-brain barrier marker (matrix metalloproteinase 9), and haemostatic markers (D-dimer and PAI-1) were measured within 24 hours after stroke onset. The discrimination and reclassification for favorable and poor outcome were compared after adding individual or a combination of blood markers to the clinical model of stroke outcome.
  
  
  RESULTS
  In multivariate analysis, natural log-transformed (log) IL-6 (odds ratio (OR): 1.75, 95% CI: 1.25 to 2.25, P=0.001) and loghFABP (OR: 3.23, 95% CI: 1.44 to 7.27, P=0.005) were independently associated with poor outcome. The addition of a single blood marker to the clinical model did not improve the discriminating ability of the clinical model of stroke outcome. However, the addition of the combination of logIL-6 and loghFABP to the clinical model showed improved discrimination (area under receiver operating characteristic (AUROC) curve: 0.939 versus 0.910, P=0.03) and reclassification performance (net reclassification improvement index: 0.18, P=0.005).
  
  
  CONCLUSIONS
  A combination of circulating IL-6 and hFABP level has an additive clinical value for the prediction of stroke outcome.
authors.forename: So-Young
authors.initials: SY
authors.lastname: Park
authors.forename: Jinkwon
authors.initials: J
authors.lastname: Kim
authors.forename: Ok-Joon
authors.initials: OJ
authors.lastname: Kim
authors.forename: Jin-Kyeoung
authors.initials: JK
authors.lastname: Kim
authors.forename: Jihwan
authors.initials: J
authors.lastname: Song
authors.forename: Dong-Ah
authors.initials: DA
authors.lastname: Shin
authors.forename: Seung-Hun
authors.initials: SH
authors.lastname: Oh
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002544:Cerebral Infarction / Q000097:blood* / Q000175:diagnosis*; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; C508600:IL6 protein, human; D015850:Interleukin-6