title: [The influence of vitamin C and E use on concentration of endothelin-1 and lipid peroxides in the serum of pregnant women with arterial hypertension].
abstract: BACKGROUND
  Hypertension occurs in 6 to 10 percent of pregnancies. It remains one of the most common disorders in pregnancy and the leading causes of maternal and fetal morbidity The changes in blood vessel endothelium have impact on the pathogenesis of hypertension and preeclampsia.
  
  
  OBJECTIVE
  The aim of this study was to establish endothelin- 1 and lipids peroxides content in blood during hypertension and the influence of vitamin C and E supplementation on the concentration of both parameters.
  
  
  METHODS
  Two study groups (pregnancy complicated with hypertension, pregnancy complicated with hypertension treated with vitamins C and E) and a control group with uncomplicated pregnancies were distinguished. Blood samples from maternal peripheral venous circulation were collected and ET-1 and lipids peroxides levels were determined from the blood samples.
  
  
  RESULTS
  Concentration of endothelin-1 in the group with hypertension and with vitamin supplementation was INCREASED (66.18 +/- 26.66 pg/ml) in comparison with normal pregnant (36.50 +/- 13.25) and hypertension group (41.02 +/- 15.98). The difference was significant. Lipid peroxides concentrations were significantly higher in the group with hypertension (1.18 +/- 0.69) in comparison with both groups - controls (0.73 +/- 0.35) and the group with hypertension and vitamin supplementation (0.77 +/- 0.42).
  
  
  CONCLUSIONS
  No significant differences in the endothelin- 1 level between healthy pregnant and pregnant women with hypertension were found. Vitamin supplementation decreases the concentrations of lipid peroxides.
authors.affiliation: Klinika Patologii Ciazy I Katedra Ginekologii i Potoznictwa Uniwersytet Medyczny w Łodzi, Polska. jpp79@wp.pl
authors.forename: Jacek
authors.initials: J
authors.lastname: Pasiński
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Swierczewski
authors.forename: Dorota
authors.initials: D
authors.lastname: Estemberg
authors.forename: Urszula
authors.initials: U
authors.lastname: Kowalska-Koprek
authors.forename: Agata
authors.initials: A
authors.lastname: Karowicz-Bilińska
mesh_terms: D000284:Administration, Oral; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004334:Drug Administration Schedule; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000188:drug therapy*; D008054:Lipid Peroxides / Q000097:blood*; D011247:Pregnancy; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D008054:Lipid Peroxides; D014810:Vitamin E; D001205:Ascorbic Acid