title: Diagnostic methods of lung cancer and its subtypes by comparative genomic hybridization.
abstract: Comparative genomic hybridization technologies have been applied to study genome-wide detection of copy number alterations in virtually all commonly diagnosed cancer types and several other diseases. The patent under evaluation describes a tool that can be used in principle to produce genome signatures with diagnostic and prognostic utility in lung cancer. Specific regions of genomic alterations correlate with either disease subtype, patient age or overall survival. The ability to characterize these phenotype-associated genome alterations in a clinical setting would presumably facilitate more robust disease diagnosis and also have potential for tailoring treatment strategies.
authors.affiliation: Massachusetts Institute of Technology Center for Cancer Research, Room E17 529, 77 Massachusetts Avenue, Cambridge MA 02139, USA cgarnis@bccrc.ca.
authors.forename: Cathie
authors.initials: C
authors.lastname: Garnis