title: Simple, clean preparation method for cross-linked α-cyclodextrin nanoparticles via inclusion complexation.
abstract: A simple, clean method was presented in this letter to prepare cross-linked α-cyclodextrin (α-CD) nanoparticles with a low dispersion. The nanoparticles were synthesized in water by cross-linking the inclusion complex of α-CDs and poly(ethylene glycol) (PEG). The structure of the nanoparticles was characterized by (1)H NMR, nuclear overhauser enhancement spectroscopy (NOESY), and wide-angle X-ray diffraction (XRD). Spherical morphology was observed by scanning electron microscopy (SEM) for these nanoparticles. Their average hydrodynamic radius was determined to be 67 nm by dynamic light scattering (DLS). Small guest molecules could be included in the cross-linked α-CD nanoparticles, and anticancer drug cisplatin was used to evaluate the drug release behavior.
authors.affiliation: Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhu
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.forename: Yongming
authors.initials: Y
authors.lastname: Chen
authors.forename: Fu
authors.initials: F
authors.lastname: Xi
mesh_terms: D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties; D047391:alpha-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D047391:alpha-Cyclodextrins; C032613:alpha-cyclodextrin