title: [Recent studies on PI3K/AKT/mTOR signaling pathway in hematopoietic stem cells].
abstract: PI3K/AKT/mTOR signaling pathway plays an essential role in the growth, proliferation and survival of various type of cells and also hematopoietic stem cells (HSC). Aberrant activation of PI3K/AKT/mTOR signaling pathway leads to exhaustion of HSC, while the inhibition of PI3K/AKT/mTOR signaling pathway results in blocking of B cell differentiation. This article reviews the latest advances on the role of key components involved in the PI3K/AKT/mTOR signaling pathway, including PI3K, AKT, mTOR, FoxO and GSK-3 in HSC.
authors.affiliation: Chinese Academy of Medical Sciences, Tianjin, China.
authors.forename: Ying-Chi
authors.initials: YC
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Cheng
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Yuan
mesh_terms: D006412:Hematopoietic Stem Cells; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; C546842:MTOR protein, human