title: Efficacy of low-dose tylvalosin for the control of clostridiosis in broilers and its effect on productive parameters.
abstract: The study was carried out under field conditions in a commercial farm, and 1,440 as-hatched Ross-308 broilers were included. Broilers were randomly distributed into 24 experimental 4-m(2) pens (60 broilers/pen). Pens were randomized to the 3 treatment groups: a) tylvalosin 10 mg/kg of live BW during 2 d, b) positive control (tylosin during 2 d), and c) negative control (no treatment). The drugs were provided in the water supply. Mortality, individual BW, and feed intake were assessed. Clostridium presence was assessed in fecal and cecal samples, coccidian oocyst counts were assessed in fecal samples, and bacterial diversity was assessed in ileal content. Live BW at 42 d old was significantly better in the tylvalosin group than in tylosin and no-treatment groups, with tylvalosin-treated broilers reaching 80 to 100 g higher final live weight. Average daily gain results mirrored BW findings. The improvement of feed conversion rate with tylvalosin amounted to 0.13 and to 0.10 versus tylosin and no-treatment, respectively, with mortality being similar in all groups. Significantly reduced sulfite-reducing Clostridium and Clostridium perfringens counts in tylvalosin and tylosin groups versus the no-treatment group were observed in cecum content samples. In conclusion, according to the present study results, tylvalosin, at doses substantially lower than registered for poultry in Europe, has proven effective in controlling the colonization of the cecum by Clostridium ssp. in broilers, improving some productive performances.
authors.affiliation: Facultad de Veterinaria, Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Garcés-Narro
authors.forename: J I
authors.initials: JI
authors.lastname: Barragán
authors.forename: M D
authors.initials: MD
authors.lastname: Soler
authors.forename: M
authors.initials: M
authors.lastname: Mateos
authors.forename: M C
authors.initials: MC
authors.lastname: López-Mendoza
authors.forename: J
authors.initials: J
authors.lastname: Homedes
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000302:isolation & purification; D044822:Biodiversity; D001835:Body Weight; D002432:Cecum / Q000382:microbiology; D002645:Chickens / Q000254:growth & development* / Q000502:physiology; D003015:Clostridium Infections / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control / Q000662:veterinary*; D003016:Clostridium perfringens / Q000302:isolation & purification; D003048:Coccidiosis / Q000469:parasitology / Q000662:veterinary; D015169:Colony Count, Microbial / Q000662:veterinary; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004435:Eating; D004539:Eimeria / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology / Q000469:parasitology; D005247:Feeding Behavior; D007082:Ileum / Q000382:microbiology; D007410:Intestinal Diseases / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012150:Polymorphism, Restriction Fragment Length; D011201:Poultry Diseases / Q000382:microbiology / Q000401:mortality / Q000469:parasitology / Q000517:prevention & control*; D012336:RNA, Ribosomal, 16S / Q000235:genetics / Q000378:metabolism; D015645:Tylosin / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S; C545430:tylvalosin; D015645:Tylosin