title: Characteristics of heme oxygenase-1 expression in rat hepatocytes during the development of nonalcoholic steatohepatitis.
abstract: We studied heme oxygenase-1 expression in rat liver during the development of nonalcoholic steatohepatitis simulated by feeding high-fat ration for 30, 90, and 180 days. Increased number of hepatocytes synthesizing heme oxygenase-1 was demonstrated at all stages of pathology development. Herewith, the intensity of enzyme expression by individual cells was reduced on experimental day 180 during the development of liver fibrosis.
authors.affiliation: Vladivostok Branch of Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Research Institute of Medical Climatology and Restoring Treatment, Russia.
authors.forename: Yu K
authors.initials: YK
authors.lastname: Karaman
authors.forename: N V
authors.initials: NV
authors.lastname: Bivalkevich
authors.forename: T P
authors.initials: TP
authors.lastname: Novgorodtseva
authors.forename: T A
authors.initials: TA
authors.lastname: Gvozdenko
mesh_terms: D000818:Animals; D005234:Fatty Liver / Q000201:enzymology*; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D022781:Hepatocytes / Q000201:enzymology*; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D051381:Rats; D017208:Rats, Wistar
chemical_list: D051547:Heme Oxygenase-1