title: Synthesis of peptide radiopharmaceuticals for the therapy and diagnosis of tumor diseases.
abstract: Despite the advances in molecular biology and biochemistry, the prognosis of patients suffering from tumor diseases remains poor. The limited therapeutic success can be explained by the insufficient performance of the common chemotherapeutic drugs that lack the ability to specifically target tumor tissues. Recently peptide radiopharmaceuticals have been developed that enable the concurrent imaging and therapy of tumors expressing a specific target. Here, with a special emphasis on the synthesis of the building blocks required for the complexation of metallic radioisotopes, the requirements to the.
authors.affiliation: Department of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany.
authors.forename: Mazen
authors.initials: M
authors.lastname: Jamous
authors.forename: Uwe
authors.initials: U
authors.lastname: Haberkorn
authors.forename: Walter
authors.initials: W
authors.lastname: Mier
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D006801:Humans; D007553:Isotope Labeling; D009369:Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000627:therapeutic use; D017433:Protein Structure, Secondary; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000627:therapeutic use; D018000:Receptors, Peptide / Q000378:metabolism
chemical_list: D002614:Chelating Agents; D006571:Heterocyclic Compounds; D009842:Oligopeptides; D019275:Radiopharmaceuticals; D018000:Receptors, Peptide