title: Presence of interleukin-17C in the tissue around aseptic loosened implants.
abstract: OBJECTIVE
  The most common long-term complication of joint arthroplasty is aseptic loosening. The proinflammatory cytokines secreted by macrophages are involved in aseptic loosening. Recently, a novel proinflammatory cytokine IL-17C was reported to participate in inflammatory diseases by synergising with proinflammatory cytokines. However, the relationship between IL-17C and the aseptic loosening is unclear.
  
  
  METHODS
  The tissues around aseptic loosened implants were collected during revision surgery and handled by formalin fixation and embedded in paraffin. The presence of IL-17C in the tissues around the aseptic loosened implants was investigated in 12 aseptic loosening patients using immunofluorescence.
  
  
  RESULTS
  The presence of IL-17C protein in the tissues around aseptic loosened implants was detected by immunofluorescence. There are no statistical differences between optical density of IL-17C in aseptic loosening samples and in rheumatoid arthritis samples (positive control).
  
  
  CONCLUSIONS
  These results suggest the presence of IL-17C in aseptic loosening. Interleukin-17C was related to the inflammation of aseptic loosening, possibly by contributing to the inflammation and osteolysis in the tissues surrounding aseptic loosened implants.
authors.affiliation: Joint Department, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 518000, China.
authors.forename: Changhe
authors.initials: C
authors.lastname: Hou
authors.forename: Yangchun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shiming
authors.initials: S
authors.lastname: Yu
authors.forename: Ziqing
authors.initials: Z
authors.lastname: Li
authors.forename: Qiyi
authors.initials: Q
authors.lastname: Zhai
authors.forename: Zhanchun
authors.initials: Z
authors.lastname: Li
authors.forename: Xibao
authors.initials: X
authors.lastname: Zhang
authors.forename: Jianhong
authors.initials: J
authors.lastname: Xiao
authors.forename: Puyi
authors.initials: P
authors.lastname: Sheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001207:Asepsis; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D020381:Interleukin-17 / Q000378:metabolism*; D007595:Joint Prosthesis; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000378:metabolism / Q000473:pathology; D057234:Preoperative Period; D011475:Prosthesis Failure
chemical_list: D020381:Interleukin-17