title: Reversible cerebral vasoconstriction syndrome.
abstract: Reversible cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular disorder with a clinical picture that continues to be refined. It has presented to multiple subspecialties over the past several decades, bringing with it many questions regarding risk factors, diagnosis, and management. Answers have been forthcoming but many questions remain. RCVS presents with recurrent, secondary thunderclap headaches and predominantly affects young women. The mechanism of vasoconstriction is unclear, but there has been speculation regarding a hyperadrenergic state. Diagnosis requires physician awareness, vascular imaging, and knowledge of the differential. The hallmark of its diagnosis is reversibility. Management is empiric, usually with calcium-channel blockers, as there are no controlled treatment trials for RCVS. Randomized controlled trials are needed.
authors.affiliation: Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.
authors.forename: Holly
authors.initials: H
authors.lastname: Yancy
authors.forename: Joyce K
authors.initials: JK
authors.lastname: Lee-Iannotti
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Schwedt
authors.forename: David W
authors.initials: DW
authors.lastname: Dodick
mesh_terms: D000328:Adult; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D014057:Tomography, X-Ray Computed; D014661:Vasoconstriction / Q000502:physiology*; D020301:Vasospasm, Intracranial / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D014711:Vertebral Artery / Q000000981:diagnostic imaging / Q000473:pathology