title: Genophenotypic analysis of angiotensinogen gene M235T polymorphism and preeclampsia.
abstract: We studied phenotypes of the circulating renin-angiotensin-aldosterone system and circadian BP during preeclampsia depending on polymorphism of angiotensinogen gene M235T. The TT genotype or T allele of angiotensinogen M235T gene polymorphism is associated with the risk of preeclampsia. Plasma renin activity significantly decreases under conditions of preeclampsia. The TT genotype of angiotensin M235T gene polymorphism is associated with highest renin activity and highest 24-h diastolic BP in comparison with MT and MM genotypes in patients with preeclampsia. Plasma aldosterone level is lower in patients with preeclampsia, but this is not related to angiotensinogen M235T gene polymorphism.
authors.affiliation: Tver' State Medical Academy, Ministry of Health Care and Social Development of the Russian Federation, Russia. unag@mail.ru
authors.forename: O V
authors.initials: OV
authors.lastname: Radkov
authors.forename: M N
authors.initials: MN
authors.lastname: Kalinkin
authors.forename: V V
authors.initials: VV
authors.lastname: Zavarin
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D001794:Blood Pressure; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000235:genetics*
chemical_list: D000808:Angiotensinogen; D000450:Aldosterone; D012083:Renin