title: The clinical utility of genetic risk variants in type 2 diabetes.
abstract: BACKGROUND
  Type 2 diabetes is one of the first success stories in the application of genome-wide linkage and association studies to find genetic variants contributing to its risk.
  
  
  OBJECTIVE
  Are the genetic markers found so far useful in predicting which individuals are more likely to develop type 2 diabetes? Can they find which patients with prediabetes are more likely to convert to type 2 diabetes and therefore may benefit the most from lifestyle or pharmacologic prevention strategies?
  
  
  METHODS
  The literature pertaining to the discovery and replications of genes contributing to type 2 diabetes was focused on.
  
  
  CONCLUSIONS
  Substantial risk for type 2 diabetes is represented by the top 8 genes, including TCF7L2, and in certain circumstances may be useful for prevention strategies targeted to those with highest risk.
authors.affiliation: Decode Genetics, Inc., Sturlugata 8, 101 Reykjavik, Iceland jeffrey.gulcher@decode.is.
authors.forename: Jeff
authors.initials: J
authors.lastname: Gulcher
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson