title: Bioengineered skin substitutes.
abstract: Bioengineered skin has great potential for use in regenerative medicine for treatment of severe wounds such as burns or chronic ulcers. Genetically modified skin substitutes have also been used as cell-based devices or "live bioreactors" to deliver therapeutics locally or systemically. Finally, these tissue constructs are used as realistic models of human skin for toxicological testing, to speed drug development and replace traditional animal-based tests in a variety of industries. Here we describe a method of generating bioengineered skin based on a natural scaffold, namely, decellularized human dermis and epidermal stem cells.
authors.affiliation: Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Amherst, NY, USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: Lei
authors.forename: Hui
authors.initials: H
authors.lastname: You
authors.forename: Stelios T
authors.initials: ST
authors.lastname: Andreadis
mesh_terms: D000826:Animal Testing Alternatives / Q000379:methods*; D006652:Histological Techniques; D006801:Humans; D007150:Immunohistochemistry; D044968:Regenerative Medicine / Q000379:methods*; D012867:Skin / Q000166:cytology / Q000293:injuries*; D017768:Skin, Artificial; D017695:Soft Tissue Injuries / Q000628:therapy*; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds