title: Effects of placental secretory factors on cytokine production by endothelial cells.
abstract: We studied the effects of soluble products of the placental tissue from women with normal pregnancy and gestosis on the cytokine secretion by endothelial EA.Hy926 cells. The secretory products of the placental tissue induced the production of angiogenin, bFGF, IL-8, MCP-1, and RANTES by endothelial cells. The secretion of bFGF by EA.Hy926 cells increased, while IL-8 secretion decreased under the effects of factors produced by the placental tissue in gestosis but not in normal pregnancy. This could be aimed at reduction of inflammation intensity in the placental tissue and maintenance of endothelial and trophoblast cells viability.
authors.affiliation: D. O. Ott Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Stepanova
authors.forename: N U
authors.initials: NU
authors.lastname: Safronova
authors.forename: K N
authors.initials: KN
authors.lastname: Furaeva
authors.forename: T U
authors.initials: TU
authors.lastname: Lvova
authors.forename: D I
authors.initials: DI
authors.lastname: Sokolov
authors.forename: S A
authors.initials: SA
authors.lastname: Selkov
mesh_terms: D002460:Cell Line; D018932:Chemokine CCL2 / Q000378:metabolism; D018946:Chemokine CCL5 / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism; D010920:Placenta / Q000166:cytology* / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D012259:Ribonuclease, Pancreatic / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D016207:Cytokines; D016209:Interleukin-8; D016222:Fibroblast Growth Factor 2; C046366:angiogenin; D012259:Ribonuclease, Pancreatic