title: CD8 T Cells and IFN-γ emerge as critical players for psoriasis in a novel model of mouse psoriasiform skin inflammation.
abstract: A pathogenic crosstalk between epithelial and immune cells underpins the aberrant immune and epidermal responses seen in psoriasis. Data from a novel mouse model of psoriasiform skin inflammation not only highlight the importance of the interplay between keratinocytes, targets of genetic manipulation, and T cells as the major effector cells, but also reveal a critical role for CD8 T cells and IFN-γ in disease initiation.
authors.affiliation: MRC National Institute for Medical Research, London, UK. pdimegl@nimr.mrc.ac.uk
authors.forename: Paola
authors.initials: P
authors.lastname: Di Meglio
authors.forename: João H
authors.initials: JH
authors.lastname: Duarte
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology*; D005260:Female; D007371:Interferon-gamma / Q000276:immunology*; D008297:Male; D016283:Proto-Oncogene Proteins p21(ras) / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D007371:Interferon-gamma; D016283:Proto-Oncogene Proteins p21(ras)