title: Local and systemic biochemical alterations induced by Bothrops atrox snake venom in mice.
abstract: The local and systemic alterations induced by Bothrops atrox snake venom (BaV) injection in mice were studied. BaV induced superoxide production by migrated neutrophils, mast cell degranulation and phagocytosis by macrophages. Moreover, BaV caused hemorrhage in dorsum of mice after 2hr post- injection. Three hours post-injection in gastrocnemius muscle, we also observed myonecrosis, which was assessed by the determination of serum and tissue CK besides the release of urea, but not creatinine and uric acid, indicating kidney alterations. BaV also induced the release of LDH and transaminases (ALT and AST) indicating tissue and liver abnormalities. In conclusion, the data indicate that BaV induces events of local and systemic importance.
authors.affiliation: Laboratório de Bioquímica e Biotecnologia/Cultivo Celular, Instituto de Pesquisas em Patologias Tropicais, IPEPATRO/FIOCRUZ Rondônia, Porto Velho-RO, Brazil.
authors.forename: Carlos At
authors.initials: CA
authors.lastname: de Souza
authors.forename: Anderson M
authors.initials: AM
authors.lastname: Kayano
authors.forename: Sulamita S
authors.initials: SS
authors.lastname: Setúbal
authors.forename: Adriana S
authors.initials: AS
authors.lastname: Pontes
authors.forename: Juliana L
authors.initials: JL
authors.lastname: Furtado
authors.forename: Fábio H
authors.initials: FH
authors.lastname: Kwasniewski
authors.forename: Kayena D
authors.initials: KD
authors.lastname: Zaqueo
authors.forename: Andreimar M
authors.initials: AM
authors.lastname: Soares
authors.forename: Rodrigo G
authors.initials: RG
authors.lastname: Stábeli
authors.forename: Juliana P
authors.initials: JP
authors.lastname: Zuliani
keywords: Bothrops atrox; Snake venom; hemorrhage; leukocytes; liver abnormalities; myonecrosis; renal failure