title: The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
abstract: A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 × 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
authors.forename: Niels
authors.initials: N
authors.lastname: Weinhold
authors.affiliation: Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors.forename: David C
authors.initials: DC
authors.lastname: Johnson
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Chubb
authors.affiliation: German Cancer Research Center, Heidelberg, Germany.
authors.forename: Bowang
authors.initials: B
authors.lastname: Chen
authors.affiliation: German Cancer Research Center, Heidelberg, Germany.|Center for Primary Health Care Research, Lund University, Malmo, Sweden.
authors.forename: Asta
authors.initials: A
authors.lastname: Försti
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors.forename: Fay J
authors.initials: FJ
authors.lastname: Hosking
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Broderick
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors.forename: Yussanne P
authors.initials: YP
authors.lastname: Ma
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors.forename: Sara E
authors.initials: SE
authors.lastname: Dobbins
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.|National Centre for Tumour Diseases, Heidelberg, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Hose
authors.affiliation: Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Walker
authors.affiliation: Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors.forename: Faith E
authors.initials: FE
authors.lastname: Davies
authors.affiliation: Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors.forename: Martin F
authors.initials: MF
authors.lastname: Kaiser
authors.affiliation: Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors.forename: Ni L
authors.initials: NL
authors.lastname: Li
authors.affiliation: University of Leeds, Leeds, UK.
authors.forename: Walter A
authors.initials: WA
authors.lastname: Gregory
authors.affiliation: Royal Victoria Infirmary, Newcastle-on-Tyne, UK.
authors.forename: Graham H
authors.initials: GH
authors.lastname: Jackson
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Witzens-Harig
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Neben
authors.affiliation: Institute of Human Genetics, University of Bonn, Germany.
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
authors.affiliation: Institute of Human Genetics, University of Bonn, Germany.|German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.affiliation: Institute of Human Genetics, University of Bonn, Germany.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Mühleisen
authors.affiliation: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
authors.forename: Lewin
authors.initials: L
authors.lastname: Eisele
authors.affiliation: Cytogenetics Group, Wessex Regional Cytogenetic Laboratory, Salisbury, UK.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Ross
authors.affiliation: Institute of Human Genetics, University of Heidelberg, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Jauch
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.|National Centre for Tumour Diseases, Heidelberg, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Goldschmidt
authors.affiliation: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
authors.affiliation: Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Morgan
authors.affiliation: German Cancer Research Center, Heidelberg, Germany.|Center for Primary Health Care Research, Lund University, Malmo, Sweden.
authors.forename: Kari
authors.initials: K
authors.lastname: Hemminki
mesh_terms: D016022:Case-Control Studies; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics*; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D009101:Multiple Myeloma / Q000209:etiology*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D014178:Translocation, Genetic
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1