title: Retinal vasoproliferative tumors: comparative clinical features of primary vs secondary tumors in 334 cases.
abstract: OBJECTIVE
  To compare the clinical features of primary vs secondary retinal vasoproliferative tumors (VPTs).
  
  
  METHODS
  Retrospective case series of 334 tumors in 295 eyes of 275 patients.
  
  
  RESULTS
  Of 275 patients with VPT, 41% (n = 113) were male and 59% (n = 162) were female, with a mean age of 44 years at presentation. Primary VPT occurred in 80% (n = 219) and secondary VPT, in 20% (n = 56) of patients. Secondary VPT (n = 67) occurred in eyes with retinitis pigmentosa (n = 15, 22%), pars planitis (n = 14, 21%), Coats disease (n = 11, 16%), previous retinal detachment surgery (n = 8, 12%), idiopathic peripheral retinal vasculitis (n = 4, 6%), familial exudative vitreoretinopathy (n = 3, 4%), and others (n = 12, 18%). The mean interval between diagnosis of underlying ocular condition and secondary VPT was 160 months. Statistically significant differences (P < .05) in clinical features (primary vs secondary VPTs) included mean age at presentation (46 vs 38 years), visual symptoms (74% vs 87%), poor visual acuity worse than 20/200 (15% vs 28%), bilaterality (4% vs 20%), multifocality (5% vs 15%), postequatorial tumor location (20% vs 33%), tumor basal dimension (6 vs 7 mm), anterior chamber cells (16% vs 30%), and vitreous cells (19% vs 48%).
  
  
  CONCLUSIONS
  Retinal vasoproliferative tumor can be primary (80%) or secondary (20%). Compared with primary VPT, secondary VPT is more often bilateral, multiple, and larger and occurs at an earlier age associated with poorer visual acuity.
authors.affiliation: The OcularOncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.forename: Swathi
authors.initials: S
authors.lastname: Kaliki
authors.forename: Saad
authors.initials: S
authors.lastname: Al-Dahmash
authors.forename: Duangnate
authors.initials: D
authors.lastname: Rojanaporn
authors.forename: Shripaad Y
authors.initials: SY
authors.lastname: Shukla
authors.forename: Brad
authors.initials: B
authors.lastname: Reilly
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005451:Fluorescein Angiography; D018324:Hemangioma, Capillary / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000209:etiology; D015868:Pars Planitis / Q000150:complications; D011183:Postoperative Complications; D012163:Retinal Detachment / Q000150:complications / Q000601:surgery; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000209:etiology; D012171:Retinal Vessels / Q000473:pathology; D012174:Retinitis Pigmentosa / Q000150:complications; D012178:Retinopathy of Prematurity / Q000150:complications; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity; D055815:Young Adult