title: TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians.
abstract: Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previously in Caucasian and Asian populations, supporting the hypothesis that TNF block haplotypes are ancient and highly conserved. They are presented here as a tool for disease-association studies.
authors.affiliation: School of Pathology and Laboratory Medicine, University of Western Australia, Western Australia, Australia.
authors.forename: C S N
authors.initials: CS
authors.lastname: Chew
authors.forename: A L
authors.initials: AL
authors.lastname: Wadley
authors.forename: Z
authors.initials: Z
authors.lastname: Lombard
authors.forename: P R
authors.initials: PR
authors.lastname: Kamerman
authors.forename: P
authors.initials: P
authors.lastname: Price
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics*; D016022:Case-Control Studies; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011153:Population / Q000235:genetics; D013019:South Africa; D048069:Tumor Necrosis Factors / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D048069:Tumor Necrosis Factors