title: A neuropeptide Y variant (rs16139) associated with major depressive disorder in replicate samples from Chinese Han population.
abstract: OBJECTIVE
  This study aimed to investigate the single nucleotide polymorphisms (SNPs) of neuropeptide Y (NPY) and major depressive disorder (MDD) in Chinese Han population.
  
  
  METHODS
  Prospective and randomized studies were carried out.
  
  
  METHODS
  A total of 700 patients (324 male and 376 female; mean age = 40±14.9 years) with depression who met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and 673 healthy controls (313 male and 360 female; mean age = 41.9±17.2 years) were used to investigate the relationship between SNPs of NPY and the pathogenesis of MDD. A total of 417 patients (195 male and 202 female; mean age = 36±14.2 years) diagnosed with MDD and 314 healthy controls (153 male and 161 female; mean age = 37.9±14.2 years) from Chinese Han population were used to verify the relationship between SNPs of NPY and the pathogenesis of MDD.
  
  
  RESULTS
  Ligase detection reactions were performed to detect the SNP sites of NPY. A series of statistical methods was carried out to investigate the correlation between the NPY gene SNP and MDD.
  
  
  RESULTS
  Statistical analysis showed a significant correlation between the SNP sites rs16139 in NPY and the morbidity of depression. Patients with MDD have a lower frequency of A-allele in rs16139 in replicate samples from Chinese Han population. However, the frequency varied between male and female patients.
  
  
  CONCLUSIONS
  The gene polymorphism loci rs16139 was closely related to MDD in Chinese Han population.
authors.affiliation: Beijing Anding Hospital, Capital Medical University, Beijing, China ; Tianjin Anding Hospital, Tianjin, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
authors.forename: Yutao
authors.initials: Y
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Hui
authors.forename: Changle
authors.initials: C
authors.lastname: Tie
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Zhi-Qing David
authors.initials: ZQ
authors.lastname: Xu
authors.forename: Chuanyue
authors.initials: C
authors.lastname: Wang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D009478:Neuropeptide Y