title: T-bet and Gata3 in controlling type 1 and type 2 immunity mediated by innate lymphoid cells.
abstract: Innate lymphoid cells (ILCs) are an emerging group of innate lymphocytes that share functional and transcriptional attributes with the various T helper cell effector fates (e.g. Th1, Th2, Th17). ILCs are substantially represented in the intestinal mucosa but are rare in secondary lymphoid organs. They play important roles in epithelial homeostasis, tissue repair and in immunity to intestinal infections. They are also involved in immune-mediated pathology. Here, we will review the emerging roles of the transcription factors T-bet and Gata3 in the development, lineage specification and function of distinct ILC lineages. We will also highlight the requirement of these transcriptional programs for the control of infections and the pathogenesis of inflammatory diseases.
authors.affiliation: Institute of Medical Microbiology and Hygiene, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoyler
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Connor
authors.forename: Elina A
authors.initials: EA
authors.lastname: Kiss
authors.forename: Andreas
authors.initials: A
authors.lastname: Diefenbach
mesh_terms: D000818:Animals; D050990:GATA3 Transcription Factor / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology*; D020825:T-Box Domain Proteins / Q000378:metabolism*; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism
chemical_list: D050990:GATA3 Transcription Factor; D020825:T-Box Domain Proteins