title: The adult mammalian pancreas contains separate precursors of pancreatic and neural crest developmental origins.
abstract: The developmental origin of a pancreatic precursor cell could provide clues to properties that may be crucial to its molecular regulation and therapeutic potential. Previously, lineage tracing experiments showed that multipotent precursors in mouse islets had a pancreatic and not a neural crest developmental origin. However, a different Cre reporter system reveals that there is, in fact, a rare population of proliferative cells in the pancreas that is descended from the Wnt1 neural crest lineage, in addition to the majority population descended from the Pdx1 pancreatic lineage. These two proliferative cell populations are distinct in their gene expression and differentiation potential. This evidence suggests that there are at least two distinct types of precursors present in adult pancreatic islets, one of pancreatic origin and one of neural crest origin.
authors.affiliation: Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. margot.arntfield@utoronto.ca
authors.forename: Margot
authors.initials: M
authors.lastname: Arntfield
authors.forename: Derek
authors.initials: D
authors.lastname: van der Kooy
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D002478:Cells, Cultured; D005136:Eye Proteins; D055785:Gene Knockdown Techniques; D018398:Homeodomain Proteins / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D009432:Neural Crest / Q000166:cytology*; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D010183:Pancreatic Ducts / Q000166:cytology* / Q000254:growth & development; D012097:Repressor Proteins; D018874:Spheroids, Cellular / Q000166:cytology; D015534:Trans-Activators / Q000378:metabolism
chemical_list: D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; C000605732:Pax6 protein, mouse; D012097:Repressor Proteins; D015534:Trans-Activators; C084010:pancreatic and duodenal homeobox 1 protein