title: Vascular endothelial growth factors (VEGFs) and stroke.
abstract: Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA. dgreenberg@buckinstitute.org
authors.forename: David A
authors.initials: DA
authors.lastname: Greenberg
authors.forename: Kunlin
authors.initials: K
authors.lastname: Jin
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D006801:Humans; D007511:Ischemia / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism / Q000637:transplantation; D055495:Neurogenesis; D020521:Stroke / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*; D042561:Vascular Endothelial Growth Factor B / Q000378:metabolism*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A; D042561:Vascular Endothelial Growth Factor B; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2