title: The influence of transition metal ions on collagen mineralization.
abstract: The ions in body fluid play an important role in bone formation besides being a synthesizing material. Transition metal ions Co(2+), Ni(2+), Zn(2+), Fe(3+), Mn(2+), Cu(2+), Cd(2+) and Hg(2+) doped hydroxyapatite (HAP)/collagen composites were synthesized successfully in the presence of collagen traces at mild acidic pH for the first time. However, the amount of doped Hg(2+) and Cd(2+) was relatively low. Meanwhile, through soaking the collagen sponge as a template in simulated body fluid (SBF) which contains different transition metal ions (Mn(2+), Cu(2+), Ni(2+), Co(2+), Cd(2+), Hg(2+)), bone-like HAP/collagen composites were synthesized. Hg(2+) had a certain inhibitory effect on the formation of HAP crystals on the surface of the collagen sponge while Co(2+) can promote the formation of HAP on the collagen sponge. For both HAP/collagen composites and HAP/collagen sponge, it was found that transition metal ions Mn(2+) had a significant effect on the morphology of HAP particles and could induce to form floc-like HAP particle aggregates.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.
authors.forename: Mingfen
authors.initials: M
authors.lastname: Jia
authors.forename: Yuanping
authors.initials: Y
authors.lastname: Hong
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Duan
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Yuan
authors.forename: Fengzhi
authors.initials: F
authors.lastname: Jiang
mesh_terms: D001826:Body Fluids / Q000737:chemistry; D003094:Collagen / Q000737:chemistry* / Q000648:ultrastructure; D017886:Durapatite / Q000737:chemistry; D007477:Ions; D008903:Minerals / Q000737:chemistry*; D011208:Powders; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D028561:Transition Elements / Q000097:blood / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D007477:Ions; D008903:Minerals; D011208:Powders; D028561:Transition Elements; D003094:Collagen; D017886:Durapatite