title: Dicoumarol complexes of Cu(II) based on 1,10-phenanthroline: synthesis, X-ray diffraction studies, thermal behavior and biological evaluation.
abstract: A series of Cu(II) complexes containing dicoumarol derivatives and 1, 10-phenanthroline have been synthesized. Structural and spectroscopic properties of ligands were studied on the basis of mass spectra, NMR ((1)H and (13)C) spectra, FT-IR spectrophotometry and elemental analysis, while physico-chemical, spectroscopic and thermal properties of mixed ligand complexes have been studied on the basis of infrared spectra, mass spectra, electronic spectra, powder X-ray diffraction, elemental analysis and thermogravimetric analysis. X-ray diffraction study suggested the suitable octahedral geometry for hexa-coordinated state. The kinetic parameters such as order of reaction (n), energy of activation (Ea), entropy (S(*)), pre-exponential factor (A), enthalpy (H(*)) and Gibbs free energy (G(*)) have been calculated using Freeman-Carroll method. Ferric-reducing antioxidant power (FRAP) of all complexes were measured. All the compounds were screened for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Streptococcus pyogenes and Bacillus subtilis, while antifungal activity against Candida albicans and Aspergillus niger have been carried out. Also compounds against Mycobacterium tuberculosis shows clear enhancement in the anti-tubercular activity upon copper complexation.
authors.affiliation: V.P. & R.P.T.P. Science College, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India. hitesh.msc123@gmail.com
authors.forename: Hitesh R
authors.initials: HR
authors.lastname: Dholariya
authors.forename: Ketan S
authors.initials: KS
authors.lastname: Patel
authors.forename: Jiten C
authors.initials: JC
authors.lastname: Patel
authors.forename: Kanuprasad D
authors.initials: KD
authors.lastname: Patel
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003300:Copper / Q000494:pharmacology*; D001728:Dicumarol / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004602:Elements; D005658:Fungi / Q000187:drug effects; D007700:Kinetics; D008024:Ligands; D060328:Magnetic Phenomena; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D010618:Phenanthrolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D000995:Antitubercular Agents; D004602:Elements; D008024:Ligands; D010618:Phenanthrolines; D003300:Copper; D001728:Dicumarol; C025205:1,10-phenanthroline