title: Synthesis of C17-OH-north unit of ritterazine G via "Red-Ox" modifications of hecogenin acetate.
abstract: The C17-OH-north unit of ritterazine G was prepared in 13 steps from hecogenin acetate. This synthesis features a highly efficient and stereoselective introduction of the C17-OH via E-ring cleavage/F-ring formation, D-ring oxidation, and F-ring cleavage/E-ring formation.
authors.affiliation: The Division of Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA.
authors.forename: Young
authors.initials: Y
authors.lastname: Cheun
authors.forename: Yi
authors.initials: Y
authors.lastname: Kou
authors.forename: Begoña
authors.initials: B
authors.lastname: Stevenson
authors.forename: Hee-Kwon
authors.initials: HK
authors.lastname: Kim
authors.forename: Myong Chul
authors.initials: MC
authors.lastname: Koag
authors.forename: Seongmin
authors.initials: S
authors.lastname: Lee
mesh_terms: D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010619:Phenazines / Q000138:chemical synthesis* / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry*
chemical_list: D010619:Phenazines; D013141:Spiro Compounds; D013256:Steroids; C505698:hecogenin acetate