title: Site-selective reactions of hydrazonoyl chlorides with cyanoacetic hydrazide and its N-arylidene derivatives and anti-aggressive activity of prepared products.
abstract: Reactions of hydrazonoyl halides with cyanoacetic hydrazide and its N-arylidene derivatives proceeded site-selectively and afforded the respective pyrazolo[3,4-d]pyridazine and aldehyde N-(1-aryl-3-acetyl-4-cyanopyrazol-5-yl)hydrazone derivatives. The structures of the products were elucidated on the basis of their spectral and elemental analyses. The anti-aggressive activity of the compounds prepared was screened.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt. as_shawali@mail.com
authors.forename: Ahmad Sami
authors.initials: AS
authors.lastname: Shawali
authors.forename: Thoraya A
authors.initials: TA
authors.lastname: Farghaly
authors.forename: Shadia M
authors.initials: SM
authors.lastname: Hussein
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Abdalla
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D004195:Disease Models, Animal; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D006835:Hydrazones; D011720:Pyrazoles; D011724:Pyridazines; C502763:pyrazolo(3,4-d)pyridazin