title: PM6 study of free radical scavenging mechanisms of flavonoids: why does O-H bond dissociation enthalpy effectively represent free radical scavenging activity?
abstract: It is well known that the bond dissociation enthalpy (BDE) of the O-H group is related to the hydrogen atom transfer (HAT) mechanism of free radical scavenging that is preferred in gas-phase and non-polar solvents. The present work shows that the BDE may also be related to radical scavenging processes taking place in polar solvents, i.e., single electron transfer followed by proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET). This is so because the total energy requirements related to the SET-PT [sum of the ionization potential (IP) and proton dissociation enthalpy (PDE)] and the SPLET [sum of the proton affinity (PA) and electron transfer enthalpy (ETE)] are perfectly correlated with the BDE. This could explain why the published data for polyphenolic antioxidant activity measured by various assays are better correlated with the BDE than with other reaction enthalpies involved in radical scavenging mechanisms, i.e., the IP, PDE, PA and ETE. The BDE is fairly well able to rank flavonoids as antioxidants in any medium, but to conclude which radical scavenging mechanism represents the most probable reaction pathway from the thermodynamic point of view, the IP and PA (ETE) should also be considered. This is exemplified in the case of the radical scavenging activity of 25 flavonoids.
authors.affiliation: Faculty of Agriculture, The Josip Juraj Strossmayer University, Kralja Petra Svačića 1d, 31000 Osijek, Croatia. damic@pfos.hr
authors.forename: Dragan
authors.initials: D
authors.lastname: Amić
authors.forename: Višnja
authors.initials: V
authors.lastname: Stepanić
authors.forename: Bono
authors.initials: B
authors.lastname: Lučić
authors.forename: Zoran
authors.initials: Z
authors.lastname: Marković
authors.forename: Jasmina M
authors.initials: JM
authors.lastname: Dimitrić Marković
mesh_terms: D005419:Flavonoids / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D006860:Hydrogen Bonding; D008956:Models, Chemical; D010084:Oxidation-Reduction; D011794:Quercetin / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D005419:Flavonoids; D016166:Free Radical Scavengers; D005609:Free Radicals; D012997:Solvents; D006859:Hydrogen; D011794:Quercetin