title: [Kidney transplantation epidemiology in France].
abstract: Kidney transplantation activity in France is among the most important worldwide: in 2011, 2976 transplants have been performed (47.5 per million population), and the number of patients living with a functional graft is estimated around 30,000, representing 44.7% of all patients (n = 67,270) treated for end-stage renal failure. However, the rate of preemptive kidney transplants remains very low, only 3.3% of incident patients starting renal replacement therapy. The analysis of demand showed a progressive increase in recent years, as demonstrated by the registration rate on the kidney transplantation waiting list, increasing by 5% yearly between 2006 and 2010, but with huge differences according to age categories and regional registration areas, reflecting discrepant appreciations in indications for kidney transplantation. The median waiting time between registration and transplantation increased progressively in recent years, reaching 22.3 months with considerable variations according to regional areas and transplantation teams. Kidney transplantation activity, while increasing continuously, is far to cover the rising demand, and inexorably patients accumulate on the waiting list (around 9000 patients were registered by January 2012). This situation is the consequence of insufficient organ procurement activity. The deceased organ procurement rate remained high: 1572 harvested donors in 2011 (24.1 per million population), but the proportion of older donors rose in recent years, to reach the rate of 26% of donors older than 65 years in 2011. The procurement activity of donors after cardiac arrest was reintroduced in 2006, but increased slowly: 65 transplants were performed in 2011 using kidney procured in non heart-beating donors. The living donor kidney transplantation activity has markedly increased recently: 302 living donor transplantations were performed in 2011, representing 10.1% of the kidney transplantations. Facing the predictable increase in the number of candidates, all efforts should be put together, by increasing the living donor transplantation activity and by supporting and promoting the deceased donor procurement activity.
authors.affiliation: Service de néphrologie et de transplantation rénale, hôpital Foch, 40, rue Worth, BP 36, 92151 Suresnes cedex, France; Université Paris-Ouest, 92000 Nanterre, France. Electronic address: christianhiesse@gmail.com.
authors.forename: Christian
authors.initials: C
authors.lastname: Hiesse
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000601:surgery; D016030:Kidney Transplantation / Q000706:statistics & numerical data* / Q000639:trends; D019520:Living Donors / Q000706:statistics & numerical data / Q000600:supply & distribution; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors / Q000706:statistics & numerical data / Q000600:supply & distribution; D020858:Tissue and Organ Harvesting / Q000706:statistics & numerical data / Q000639:trends; D009927:Tissue and Organ Procurement; D014850:Waiting Lists; D055815:Young Adult
keywords: Donneur vivant; End-stage renal failure; Epidemiology; Greffe préemptive; Insuffisance rénale chronique terminale; Kidney transplantation; Living donor; Organ procurement; Preemptive transplantation; Prélèvement d’organes; Transplantation rénale; Épidémiologie