title: NKG2D ligands link oncogenic RAS to innate immunity.
abstract: RAS is constitutively active in multiple types of tumor cells. We have recently demonstrated that H-RASV12 enhances the translation of ligands for the activating immune receptor NKG2D, hence rendering cells more susceptible to natural killer (NK) cell-mediated lysis. This effect depends on MAPK and PI3K signaling, but not on the DNA damage response.
authors.affiliation: Immunology Programme; Centre of Life Sciences, Department of Microbiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.
authors.forename: Samantha S W
authors.initials: SS
authors.lastname: Ho
authors.forename: Stephan
authors.initials: S
authors.lastname: Gasser
keywords: NK cells; cytotoxicity; signal transduction; tumor immunology