title: Taurine-magnesium coordination compound attenuates hypoxia/reoxygenation induced ion channel dysfunction in rat ventricular myocytes.
abstract: Because of the known anti-arrhythmic effects of taurine-magnesium coordination compound (TMCC), the aim of the present study was to explore the electrophysiological effects of TMCC on hypoxia/reoxygenation (H/R)-induced arrhythmias in rat ventricular myocytes. Sodium current (I Na), the L-type calcium current (I Ca,L), and the transient outward potassium current (I to) were evaluated using whole-cell patch-clamp recordings in rat ventricular myocytes following H/R injury. The H/R group significantly decreased sodium currents, while L-type calcium currents and transient outward potassium currents was significantly increased (all p<0.01). TMCC (200 and 400 μM) prevented abnormal sodium currents induced by H/R by inhibiting steady-state inactivation. It also counteracted abnormal L-type calcium currents induced by H/R by inhibiting steady-state activation and facilitating steady-state inactivation. In addition, it mitigated abnormal transient outward potassium currents induced by H/R by inhibiting steady-state activation. TMCC prevents H/R-induced arrhythmias in rat ventricular myocytes by modifying ion channel function.
authors.affiliation: Department of Pharmacology, Tianjin Medical University, Tianjin, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhao
authors.forename: J-S
authors.initials: JS
authors.lastname: Lou
authors.forename: Y
authors.initials: Y
authors.lastname: Kang
mesh_terms: D000818:Animals; D020746:Calcium Channels, L-Type / Q000187:drug effects; D005260:Female; D006352:Heart Ventricles; D007473:Ion Channels / Q000187:drug effects*; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism; D015221:Potassium Channels / Q000187:drug effects; D051381:Rats; D015222:Sodium Channels / Q000187:drug effects; D013654:Taurine / Q000494:pharmacology*
chemical_list: D020746:Calcium Channels, L-Type; D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels; D013654:Taurine; D008274:Magnesium