title: Prognostic role of microRNA-155 in various carcinomas: results from a meta-analysis.
abstract: BACKGROUND
  Recent studies have shown that microRNAs (miRNA) have prognostic values in cancers. This meta-analysis seeks to summarize the global predicting role of miR-155 for survival in patients with a variety of carcinomas.
  
  
  METHODS
  Eligible studies were identified through multiple search strategies. Data were extracted from studies investigating the relationship between miR-155 expression and survival in cancer patients. Combined hazard ratios (HRs) of miR-155 for outcome were analyzed.
  
  
  RESULTS
  A total of 16 studies dealing with various carcinomas were included for this meta-analysis. For overall survival, higher miR-155 expression could significantly predict worse outcome with the pooled HR of 2.057 (95% CI: 1.392-3.039). For relapse or progress-free survival, elevated miR-155 was also a significant predictor, with a combined HR of 1.918 (95% CI: 1.311-2.806,). In addition, subgroup analysis showed that higher expression of miR-155 had the trends to predict worse outcome in lung cancer. However, the HRs did not reach the statistical significance.
  
  
  CONCLUSIONS
  Our findings suggest that miR-155 detection has a prognostic value in cancer patients. Regularly measuring miR-155 expression may be useful in clinical practice.
authors.affiliation: Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.forename: Fengmei
authors.initials: F
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhu
authors.forename: Xuelian
authors.initials: X
authors.lastname: He
authors.forename: Yuhang
authors.initials: Y
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yulan
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D002277:Carcinoma / Q000175:diagnosis* / Q000628:therapy; D018572:Disease-Free Survival; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs