title: [Measurement of acetonitrile in blood and urine by head-space gas chromatography].
abstract: OBJECTIVE
  To establish the method for measurement of acetonitrile in blood and urine by head-space gas chromatography.
  
  
  METHODS
  DB-ALC1 (30 m x 320 microm x 1.8 microm) and DB-ALC2 (30 m x 320 microm x 1.2 microm) capillary column were used to measure the acetonitrile in blood and urine with the isopropanol as internal standard reference.
  
  
  RESULTS
  The limits of detection of acetonitrile in both blood and urine were 0.5 microg/mL, with a linear range of 5-1000 microg/mL (r = 0.999).The accuracy of this method was 93.2%-98.0%. The RSD for the intra-day and inter-day were less than 3.7%.
  
  
  CONCLUSIONS
  The method is capable for measurement analysis of acetonitrile in blood and urine.
authors.affiliation: School of Pharmacy, Medical College of Soochow University, Suzhou 215123, China. luoruxin1986@sina.cn
authors.forename: Ru-Xin
authors.initials: RX
authors.lastname: Luo
authors.forename: Xian-Yi
authors.initials: XY
authors.lastname: Zhuo
authors.forename: Bao-Hua
authors.initials: BH
authors.lastname: Shen
mesh_terms: D000097:Acetonitriles / Q000097:blood* / Q000506:poisoning* / Q000652:urine*; D002849:Chromatography, Gas / Q000379:methods*; D003486:Cyanides / Q000097:blood / Q000652:urine; D053593:Forensic Toxicology / Q000379:methods; D006801:Humans; D015203:Reproducibility of Results; D013406:Suicide, Attempted
chemical_list: D000097:Acetonitriles; D003486:Cyanides; C032159:acetonitrile