title: Exposure to solvents in health care workers: assessment of the hepatic effects.
abstract: OBJECTIVE
  The use of organic solvents has been linked to pathologies of different apparatuses. The purpose of this study is to analyze the liver damage induced by organic solvents.
  
  
  METHODS
  We analyzed 556 workers, 278 exposed to organic solvents (group 1) and 278 not exposed to organic solvents (group 2). The exposed group was further divided into 2 subgroups: group 1A (139 workers exposed to considerable doses) and group 1B (139 workers exposed to negligible doses). Mean and standard deviation of some liver parameters was calculated. Statistically significant differences between the liver parameters in the different groups and subgroups were detected using the t-test. Multiple linear regression models were used to examine the associations between laboratory parameters and the independent variable.
  
  
  RESULTS
  The data so far obtained showed the existence of statistically significant differences with regard to the total protein, total bilirubin, transaminase GOT and GPT, Gamma Glutamyl Transferase (gamma-GT).
  
  
  CONCLUSIONS
  Our results confirm that exposure to solvents can alter some liver parameters. The blood tests we used can be useful tool for the assessment of the actual occupational hazards and to verify the effectiveness of the measures taken for the prevention and protection.
authors.affiliation: Department of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine, Sapienza University of Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Caciari
authors.forename: T
authors.initials: T
authors.lastname: Casale
authors.forename: B
authors.initials: B
authors.lastname: Pimpinella
authors.forename: L
authors.initials: L
authors.lastname: Montuori
authors.forename: L
authors.initials: L
authors.lastname: Trovè
authors.forename: G
authors.initials: G
authors.lastname: Tomei
authors.forename: A
authors.initials: A
authors.lastname: Capozzella
authors.forename: M P
authors.initials: MP
authors.lastname: Schifano
authors.forename: M
authors.initials: M
authors.lastname: Fiaschetti
authors.forename: B
authors.initials: B
authors.lastname: Scala
authors.forename: F
authors.initials: F
authors.lastname: Tomei
authors.forename: M V
authors.initials: MV
authors.lastname: Rosati
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000410:Alanine Transaminase / Q000097:blood; D000428:Alcohol Drinking / Q000453:epidemiology; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007755:Laboratories, Hospital; D059232:Laboratory Personnel / Q000706:statistics & numerical data; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure; D010564:Personnel, Hospital / Q000706:statistics & numerical data; D012907:Smoking / Q000453:epidemiology; D012997:Solvents / Q000633:toxicity*; D055549:Volatile Organic Compounds / Q000633:toxicity*; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D001798:Blood Proteins; D012997:Solvents; D055549:Volatile Organic Compounds; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin