title: Time course of thrombocytes in burn patients and its predictive value for outcome.
abstract: Thrombocytopenia is common in trauma and critically ill patients and is associated with a poor outcomes. The objective of this retrospective study was to investigate the course of thrombocyte concentration changes in burn patients, the influences of various factors on this course, and a possible predictive value of thrombocyte counts on outcome in 244 patients admitted to our burn centre. Their thrombocyte counts were obtained until 50 days after burn. Data on patient demographics, total percentage burned surface area (%TBSA), sepsis and mortality were collected. Multilevel multivariable analysis was performed to investigate the influence of the variables on the platelet course. Cox regression analysis was performed to analyse the predictive value of the variables for mortality. A distinct pattern of thrombocyte counts was observed, with a nadir at day 3 followed by a peak at day 15 and a temporary thrombocytosis. %TBSA and age (p<0.05) influence this course. The mean thrombocyte course of septic and non-surviving patients depicts a significant lower nadir. Furthermore, higher age, %TBSA and low thrombocyte counts at the peak are predictive for 50 day mortality (p<0.05). Platelets follow a distinct course after burn, influenced by %TBSA and age. These factors and a low thrombocyte peak count predict mortality.
authors.affiliation: Association Dutch Burn Centers, Beverwijk, The Netherlands. roosmarck@me.com
authors.forename: Roos Elisabeth
authors.initials: RE
authors.lastname: Marck
authors.forename: Harriet Leonie
authors.initials: HL
authors.lastname: Montagne
authors.forename: Willem Eduard
authors.initials: WE
authors.lastname: Tuinebreijer
authors.forename: Roelf Simon
authors.initials: RS
authors.lastname: Breederveld
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000166:cytology*; D002056:Burns / Q000097:blood* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012189:Retrospective Studies; D018805:Sepsis / Q000097:blood; D012737:Sex Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers