title: Biologic agents in experimental autoimmune uveitis.
abstract: Experimental uveitis models were developed in an effort to elucidate the pathogenesis of human uveitis. The therapeutic effects of numerous anti-inflammatory agents including corticosteroids and immunomodulatory agents including biologic response modifiers have been investigated in both experimental and human uveitis. Monoclonal antibodies to tumor necrosis factor alpha and anti-interleukins, among others, demonstrate efficacy and are employed in the treatment of uveitis refractory to conventional immunomodulatory agents.
authors.affiliation: Centro de Cirugía Oftalmológica (CECOF), Caracas, Venezuela, gpgiuliari@gmail.com.
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Giuliari
authors.forename: Ama
authors.initials: A
authors.lastname: Sadaka
authors.forename: David M
authors.initials: DM
authors.lastname: Hinkle
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy*; D001685:Biological Factors / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007167:Immunotherapy; D007378:Interleukins / Q000276:immunology; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000379:methods*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D014605:Uveitis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D001685:Biological Factors; D018796:Immunoconjugates; D007166:Immunosuppressive Agents; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha