title: Angiotensin-converting enzyme insertion/deletion gene polymorphisms and risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies.
abstract: Studies investigating the association between the intron 16 insertion/deletion (I/D) polymorphism (rs4646994) in the angiotensin-converting enzyme (ACE) gene and risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. Published literature from the National Library of Medline and Embase databases were retrieved. Odds ratios (OR) and 95% confidence limits (CLs) were calculated in fixed- or random-effects models when appropriate. Subgroup analyses were performed by race. This meta-analysis included six case-control studies, which included 744 ICH cases and 1411 controls. The combined results based on all studies showed that ICH cases had a significantly lower frequency of ID genotype (OR (codominant model) = 0.43, 95% CL = 0.22, 0.84, p = 0.01). In the subgroup analysis by race, we found that ICH cases had a significantly lower frequency of II genotype in Asians (OR (recessive model) = 0.50, 95% CL = 0.38, 0.66, p < 0.001; OR (codominant model) = 0.25, 95% CL = 0.09, 0.71, p = 0.009). In conclusion, our meta-analysis suggests that ACE I/D polymorphisms are associated with ICH, especially in Asians.
authors.affiliation: Department of Neurosurgery, Guangxi Minzu Hospital, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Guang
authors.initials: G
authors.lastname: Li
authors.forename: Huan
authors.initials: H
authors.lastname: Lan
authors.forename: GuanYan
authors.initials: G
authors.lastname: Zhao
authors.forename: ChunZhen
authors.initials: C
authors.lastname: Huang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage; D056726:Genetic Association Studies; D006801:Humans; D054643:INDEL Mutation; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme; gene polymorphism; intracerebral hemorrhage; meta-analysis