title: Pregnancy-related human leukocyte antigen sensitization leading to cardiac allograft vasculopathy and graft failure in a heart transplant recipient: a case report.
abstract: In this report, we present a heart transplant recipient who developed cross-reactive paternal and donor-specific human leukocyte antigen (HLA) class II antibodies during pregnancy, leading to accelerated cardiac allograft vasculopathy and severe allograft dysfunction 17 years after transplantation. This resulted in acute heart failure and ventricular arrhythmias requiring repeat heart transplantation.
authors.affiliation: Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: M
authors.initials: M
authors.lastname: Ginwalla
authors.forename: M J
authors.initials: MJ
authors.lastname: Pando
authors.forename: K K
authors.initials: KK
authors.lastname: Khush
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000276:immunology; D009202:Cardiomyopathies / Q000601:surgery*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D003429:Cross Reactions; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D006680:HLA Antigens / Q000276:immunology*; D006333:Heart Failure / Q000276:immunology; D016027:Heart Transplantation / Q000009:adverse effects / Q000276:immunology*; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007518:Isoantibodies / Q000097:blood*; D011247:Pregnancy; D012086:Reoperation; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D006680:HLA Antigens; D007166:Immunosuppressive Agents; D007518:Isoantibodies