title: Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control.
abstract: The purpose of this review is to outline our latest hypothesis on the mechanisms responsible for the genesis of paradoxical (REM) sleep (PS). On the basis of recent data, we propose that the onset and maintenance of PS are due to the activation by intrinsic and extrinsic factors of MCH/GABAergic neurons located in the lateral hypothalamic area. These neurons would inhibit during PS, GABAergic PS-off neurons located in the ventrolateral periaqueductal gray region. A number of results strongly suggest that these PS-off neurons gate the activation of the PS-on glutamatergic neurons located in the sublaterodorsal tegmental nucleus (SLD) and responsible for cortical activation and muscle atonia via descending projections to GABA/glycinergic neurons localized in the ventral medullary reticular nuclei.
authors.affiliation: INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Team "Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil", Lyon, France; University Lyon 1, Lyon, France. Electronic address: luppi@sommeil.univ-lyon1.fr.
authors.forename: Pierre-Hervé
authors.initials: PH
authors.lastname: Luppi
authors.forename: Olivier
authors.initials: O
authors.lastname: Clément
authors.forename: Patrice
authors.initials: P
authors.lastname: Fort
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology*