title: Topical latanoprost does not cause macular thickening after uncomplicated cataract surgery.
abstract: OBJECTIVE
  To explore changes in central macular thickness (CMT) after a two-month period of glaucoma therapy with topical latanoprost after uneventful phacoemulsification.
  
  
  METHODS
  Forty-one eyes of 31 patients with primary open angle or pseudoexfoliative glaucoma who required glaucoma medications after cataract surgery were prospectively enrolled. All eyes had undergone uneventful phacoemulsification with intraocular lens implantation at least 4 months before initiation of latanoprost. After a complete ophthalmic examination, spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) were performed at baseline before starting latanoprost. All eyes received latanoprost for 2 months, and clinical examinations were repeated one and two months afterwards; OCT and FA were repeated after 2 months. Outcome measures were CMT and loss of more than 2 lines of best corrected visual acuity (BCVA).
  
  
  RESULTS
  Mean patient age was 71.6±7.8 years. Intraocular pressure decreased from 21.5±3.4 mmHg to 14.4±2.6 mmHg (p<0.001) at 2 months. None of the eyes developed reduction of BCVA exceeding 2 lines, or angiographic cystoid macular edema (CME). Likewise no significant change was noted in CMT (249.9±29.8 vs 248.8±30.7µm), average macular thickness (274.5±15.0 vs 273.8±17.0µm), or macular volume (9.6±1.0 vs 9.6±1.1µm2) after treatment as compared to baseline (P>0.05 for all comparisons).
  
  
  CONCLUSIONS
  Topical use of latanoprost later than 4 months after uncomplicated cataract surgery does not seem to predispose to increased macular thickness or CME and may safely be used in this setting.
authors.affiliation: Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sasan
authors.initials: S
authors.lastname: Moghimi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Zandian
authors.forename: Golshan
authors.initials: G
authors.lastname: Latifi
authors.forename: Heydar
authors.initials: H
authors.lastname: Amini
authors.forename: Yadollah
authors.initials: Y
authors.lastname: Eslami
authors.forename: Reza
authors.initials: R
authors.lastname: Zarei
authors.forename: Ghasem
authors.initials: G
authors.lastname: Fakhraie
authors.forename: Kouros
authors.initials: K
authors.lastname: Nouri-Mahdavi
keywords: Cystoid Macular Edema; Latanoprost; Macular Thickness