title: A single-molecule force spectroscopy study of the interactions between lectins and carbohydrates on cancer and normal cells.
abstract: The interaction forces between carbohydrates and lectins were investigated by single-molecule force spectroscopy on both cancer and normal cells. The binding kinetics was also studied, which shows that the carbohydrate-lectin complex on cancer cells is less stable than that on normal cells.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhao
authors.forename: Mingjun
authors.initials: M
authors.lastname: Cai
authors.forename: Haijiao
authors.initials: H
authors.lastname: Xu
authors.forename: Junguang
authors.initials: J
authors.lastname: Jiang
authors.forename: Hongda
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000737:chemistry; D004285:Dogs; D005947:Glucose / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D061985:Madin Darby Canine Kidney Cells; D008358:Mannose / Q000737:chemistry*; D018625:Microscopy, Atomic Force / Q000379:methods*; D009369:Neoplasms / Q000737:chemistry*; D011485:Protein Binding; D013057:Spectrum Analysis / Q000379:methods*; D014909:Wheat Germ Agglutinins / Q000737:chemistry*
chemical_list: D000954:Antigens, Surface; D014909:Wheat Germ Agglutinins; D005947:Glucose; D008358:Mannose