title: Establishing the role of tyrosine kinase 2 in cancer.
abstract: Tyrosine kinase 2 (TYK2) is a member of the Janus family of non-receptor tyrosine kinases involved in cytokine signaling. TYK2 deficiency is associated with increased susceptibility to mycobacterial and viral infections, hyper IgE syndrome as well as with allergic asthma. However the precise role of TYK2 in oncogenesis and tumor progression is not clear yet. Tyk2-deficient mice are prone to develop tumors because they lack efficient cytotoxic CD8+T-cell antitumor responses as a result of deficient Type I interferon signaling. However, as TYK2 functions downstream of growth factor receptors that are often hyperactivated in cancer, inhibiting TYK2 might also have beneficial effects for cancer treatment.
authors.affiliation: Laboratory of Cellular and Molecular Lung Immunology; Institute of Molecular Pneumology; University of Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: Caroline
authors.initials: C
authors.lastname: Ubel
authors.forename: Stephanie
authors.initials: S
authors.lastname: Mousset
authors.forename: Denis
authors.initials: D
authors.lastname: Trufa
authors.forename: Horia
authors.initials: H
authors.lastname: Sirbu
authors.forename: Susetta
authors.initials: S
authors.lastname: Finotto
keywords: JAK-STAT signalling; TYK2; cancer; cytokines; lung cancer; tumor therapy