title: Absorption of proteoglycan via clathrin-mediated endocytosis in the small intestine of rats.
abstract: The mechanism underlying proteoglycan (PG) absorption in the intestine is not clear. Hence we analyzed the transport of salmon PG in the rat jejunum, ileum, and colon by the everted-sac method. The jejunum showed the largest capacity for PG transport. Jejunal transport of PG was also greater than that of chondroitin A and C. An inhibitor of clathrin-mediated endocytosis reduced jejunal PG transport. We conclude that intestinal PG transport is highest in the jejunum, and is partially dependent on clathrin-mediated endocytosis.
authors.affiliation: Department of Home Economics, Tohoku Women's College, Hirosaki, Aomori, Japan. ytsuchiya@tojo.ac.jp
authors.forename: Yo
authors.initials: Y
authors.lastname: Tsuchiya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tomita
authors.forename: Makoto
authors.initials: M
authors.lastname: Tsuboi
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Takahashi
authors.forename: Masato
authors.initials: M
authors.lastname: Yonezuka
authors.forename: Satomi
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Sanae
authors.initials: S
authors.lastname: Nagasawa
authors.forename: Airi
authors.initials: A
authors.lastname: Kumazawa
authors.forename: Junko
authors.initials: J
authors.lastname: Kubota
mesh_terms: D000818:Animals; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism*; D051381:Rats
chemical_list: D002966:Clathrin; D011509:Proteoglycans