title: [Fluid-structure interaction analysis based on a 3D finite element model of human left ventricular].
abstract: A 3D model of heart configurations and interior structures has been constructed using Visual C++ visualization toolkit based on the Dataset of Visible Chinese Human. The finite element model of left ventricular is obtained from the heart structure model. Both ventricular wall and blood in the cavity are modeled by finite element mesh. The fluid-structure coupling of the left ventricle and blood has been constructed using an arbitrary Lagrange-Euler algorithm. Based on these models, the fluid-structure interaction of the left ventricle and blood in the filling phase is simulated. The simulation result successfully reproduced the biphasic filling flow consisting of early rapid filling and atrial contraction, which is similar to the clinical observation. This study provides a feasible method with which we can use image-based fluid-structure simulation to analyse the structure and haemodynamics properties of heart. It could be applied in heart functional investigations and clinical applications.
authors.affiliation: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.forename: Kaijun
authors.initials: K
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Wan
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D020342:Finite Element Analysis; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006439:Hemodynamics; D006801:Humans; D021621:Imaging, Three-Dimensional; D008955:Models, Cardiovascular