title: Consumption of Chinese tea-flavor liquor improves circulating insulin levels without affecting hepatic lipid metabolism-related gene expression in Sprague-Dawley rats.
abstract: OBJECTIVE
  To examine the effect of two Chinese liquors with quite different nonalcoholic components on insulin sensitivity, tissue polyunsaturated fatty acids (PUFA), and hepatic lipid metabolism in SD rats.
  
  
  METHODS
  Thirty-three SD rats were randomized into four groups and maintained in each treatment for 10 weeks: Chinese tea-flavor liquor (TFL, n=9), traditional Chinese liquor (TCL, n=8), ethanol control (EC, n=8), and water control (WC, n=8).
  
  
  RESULTS
  TFL significantly decreased plasma insulin (P=0.009) and marginally decreased Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) (P=0.05), compared with WC. Hepatic total and n-6 PUFA compositions were significantly decreased in TFL, TCL, and EC groups compared with WC group (P<0.05). TFL significantly increased kidney n-6 PUFA (P=0.05) and total PUFA (P=0.039), compared with EC group. EC group showed significant higher gene expressions of acetyl-CoA carboxylase and steroid response element-binding protein (1c and 2), while there were no significant differences of these gene expressions in TFL or TCL group compared with WC.
  
  
  CONCLUSIONS
  TFL has a beneficial effect on metabolic disorder in relation to improved circulating insulin levels without affecting hepatic lipid metabolism-related gene expressions in rats.
authors.affiliation: Department of Food Science and Nutrition, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.
authors.forename: Ju-Sheng
authors.initials: JS
authors.lastname: Zheng
authors.forename: Yuan-Qing
authors.initials: YQ
authors.lastname: Fu
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Duo
authors.initials: D
authors.lastname: Li
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000434:Alcoholic Beverages; D000818:Animals; D001835:Body Weight; D004353:Drug Evaluation, Preclinical; D015525:Fatty Acids, Omega-3 / Q000097:blood / Q000378:metabolism; D005421:Flavoring Agents / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000032:analysis; D007328:Insulin / Q000097:blood* / Q000235:genetics; D007333:Insulin Resistance; D007668:Kidney / Q000378:metabolism; D050356:Lipid Metabolism / Q000235:genetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015525:Fatty Acids, Omega-3; D005421:Flavoring Agents; D007004:Hypoglycemic Agents; D007328:Insulin; D012333:RNA, Messenger; D000103:Acetyl-CoA Carboxylase