title: Cocaine postmortem distribution in three brain structures: a comparison with whole blood and vitreous humour.
abstract: The presence of cocaine (COC) in fluids or tissues does not prove that death was due to drug consumption and the interpretation of postmortem concentrations is more complex than attempts at making such correlations in the living. The purpose of this study was to investigate the distribution of cocaine and its metabolite benzoylecgonine in brain and compare with whole blood and vitreous humour. The distribution in three brain structures (prefrontal cortex, basal ganglia and cerebellum) was homogeneous. There is a strong correlation for cocaine concentrations between vitreous humour and brain, vitreous humour and whole blood, and whole blood and brain in overdose cases. In addition, the comparison of COC/benzoylecgonine (BE) ratios in different experimental specimens proved to be more appropriate for evaluating cocaine-related death than individual drug values. These findings suggest that the comparison of cocaine levels in different compartments is essential to assess the cause of death.
authors.affiliation: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, Departamento de Análises Clínicas e Toxicológicas, Av. Prof. Lineu Prestes, 580, 05508-900 São Paulo, Brazil. vmcar@usp.br
authors.forename: Virginia M
authors.initials: VM
authors.lastname: Carvalho
authors.forename: André R
authors.initials: AR
authors.lastname: Fukushima
authors.forename: Luiz R
authors.initials: LR
authors.lastname: Fontes
authors.forename: Daniela V
authors.initials: DV
authors.lastname: Fuzinato
authors.forename: Jorge C
authors.initials: JC
authors.lastname: Florio
authors.forename: Alice A M
authors.initials: AA
authors.lastname: Chasin
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001479:Basal Ganglia / Q000737:chemistry*; D002531:Cerebellum / Q000737:chemistry*; D003042:Cocaine / Q000031:analogs & derivatives / Q000032:analysis* / Q000493:pharmacokinetics; D062787:Drug Overdose; D005260:Female; D053593:Forensic Toxicology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009294:Narcotics / Q000032:analysis* / Q000493:pharmacokinetics; D011180:Postmortem Changes; D017397:Prefrontal Cortex / Q000737:chemistry*; D014822:Vitreous Body / Q000737:chemistry*; D055815:Young Adult
chemical_list: D009294:Narcotics; C005618:benzoylecgonine; D003042:Cocaine