title: The cell biology of genomes: bringing the double helix to life.
abstract: The recent ability to routinely probe genome function at a global scale has revolutionized our view of genomes. One of the most important realizations from these approaches is that the functional output of genomes is affected by the nuclear environment in which they exist. Integration of sequence information with molecular and cellular features of the genome promises a fuller understanding of genome function.
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. mistelit@mail.nih.gov
authors.forename: Tom
authors.initials: T
authors.lastname: Misteli
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D057890:Epigenomics; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D014158:Transcription, Genetic
chemical_list: D004247:DNA