title: Alkane C-H insertion by aryne intermediates with a silver catalyst.
abstract: Arynes generated directly from alkyne building blocks in the presence of silver catalysts effectively activate primary, secondary, and tertiary alkane C-H bonds. This C-H insertion requires only a catalytic amount of silver complex and modest heating compared to harsh conditions and extra promoters including directing groups, oxidants, and bases in typical transition-metal-based C-H bond functionalizations. Preliminary mechanistic studies suggest that the C-H bond-breaking and new bond-forming events take place in a concerted manner, rendering a formal 1,2-addition of C-H bond across the π-bond of arynes.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, USA.
authors.forename: Sang Young
authors.initials: SY
authors.lastname: Yun
authors.forename: Kung-Pern
authors.initials: KP
authors.lastname: Wang
authors.forename: Nam-Kyu
authors.initials: NK
authors.lastname: Lee
authors.forename: Phani
authors.initials: P
authors.lastname: Mamidipalli
authors.forename: Daesung
authors.initials: D
authors.lastname: Lee