title: Experimental study on the efficacy of the drug Brizantin in the model of nicotine dependence.
abstract: We estimated the efficacy of Brizantin preparation in suppressing nicotine dependence in rats. It was shown that nicotine-dependent rats in the situation of choice between the chamber with smoke or the chamber with food more frequently entered the chamber with tobacco smoke and stayed there longer. The rats that received Brizantin demonstrated significantly fewer visits to the chamber with smoke and spent there less time. Reduced locomotor activity and orientation and exploratory behavior in rats against the background of Brizantin administration also suggest reduced motivation for smoke inhalation. Thus, Brizantin effectively diminished nicotine dependence in rats in the model of nicotine addiction.
authors.affiliation: Materia Medica Holding Research-and-Production Company, Moscow, Russia. nauka@materiamedica.ru
authors.forename: I A
authors.initials: IA
authors.lastname: Kheyfets
authors.forename: T M
authors.initials: TM
authors.lastname: Vorob'eva
authors.forename: E V
authors.initials: EV
authors.lastname: Veselovskaya
authors.forename: A V
authors.initials: AV
authors.lastname: Shlyahova
authors.forename: N A
authors.initials: NA
authors.lastname: Kirillova
authors.forename: S P
authors.initials: SP
authors.lastname: Kolyadko
authors.forename: O G
authors.initials: OG
authors.lastname: Berchenko
authors.forename: J L
authors.initials: JL
authors.lastname: Dugina
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D002755:Choice Behavior / Q000187:drug effects*; D004338:Drug Combinations; D005106:Exploratory Behavior / Q000187:drug effects*; D005508:Food Deprivation; D006815:Hunger; D008297:Male; D009042:Motivation; D009538:Nicotine; D051381:Rats; D012646:Self Administration; D012906:Smoke; D012907:Smoking / Q000188:drug therapy; D014029:Tobacco Use Disorder / Q000188:drug therapy*
chemical_list: D000906:Antibodies; C583479:Brizantin; D004338:Drug Combinations; D012906:Smoke; D009538:Nicotine