title: First enantioselective synthesis of tetracyclic intermediates en route to madangamine D.
abstract: The enantioselective synthesis of advanced tetracyclic precursors of madangamine D, bearing rings ABCD of this alkaloid, is reported. The saturated 14-membered ring is assembled from functionalized diazatricyclic intermediates following either ring-closing metathesis or macrolactamization strategies.
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona, 08028-Barcelona, Spain. amat@ub.edu
authors.forename: Mercedes
authors.initials: M
authors.lastname: Amat
authors.forename: Roberto
authors.initials: R
authors.lastname: Ballette
authors.forename: Stefano
authors.initials: S
authors.lastname: Proto
authors.forename: Maria
authors.initials: M
authors.lastname: Pérez
authors.forename: Joan
authors.initials: J
authors.lastname: Bosch
mesh_terms: D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; C583216:madangamine D