title: A rare case of squamous cell carcinoma of the lung harbouring ALK and BRAF activating mutations.
abstract: The management of non-small cell lung cancer has significantly changed over the past few years through greater understanding of tumour biology. The identification of activating mutations has led to the development of targeted agents. Coexisting mutations in non-small cell lung cancer is uncommon, particularly in squamous cell carcinoma. Our case represents a late gentleman with squamous cell carcinoma of the lung with both a BRAF mutation and ALK rearrangement prior to treatment.
authors.affiliation: St Georges Healthcare NHS Trust, London, UK. doraid123@hotmail.com
authors.forename: Doraid
authors.initials: D
authors.lastname: Alrifai
authors.forename: Sanjay
authors.initials: S
authors.lastname: Popat
authors.forename: Merina
authors.initials: M
authors.lastname: Ahmed
authors.forename: David
authors.initials: D
authors.lastname: Gonzalez
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Nicholson
authors.forename: John du
authors.initials: Jd
authors.lastname: Parcq
authors.forename: Tim
authors.initials: T
authors.lastname: Benepal
mesh_terms: D000368:Aged; D000077548:Anaplastic Lymphoma Kinase; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D015533:Transcriptional Activation
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf