title: Multi-residue analysis of pesticides in agricultural products by liquid chromatography time-of-flight mass spectrometry.
abstract: The applicability of liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS) for determining pesticide residues in agricultural products was investigated. TOF-MS conditions for monitoring target ions, together with their fragment ions, were carefully optimized. The developed LC-TOF-MS method was evaluated for 154 pesticides in soybean and spinach by using matrix-matched standards. No significant matrix effect was observed for most of the tested pesticides at a concentration level of 0.01 mg/kg, where the limits of quantification were less than 0.01 mg/kg for 145 of the 154 pesticides (S/N>10). In addition, no significant interference was observed in the chromatograms of the blank extracts. These results indicate that LC-TOF-MS determination may become a powerful tool for multi-residue analysis of pesticides in agricultural products.
authors.affiliation: National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan. shizsaito@nihs.go.jp
authors.forename: Shizuka
authors.initials: S
authors.lastname: Saito
authors.forename: Satoru
authors.initials: S
authors.lastname: Nemoto
authors.forename: Rieko
authors.initials: R
authors.lastname: Matsuda
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D018556:Crops, Agricultural / Q000737:chemistry*; D005504:Food Analysis / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D010573:Pesticide Residues / Q000032:analysis*
chemical_list: D010573:Pesticide Residues