title: Fish oil prevents excessive hepatic lipid accumulation without inducing oxidative stress.
abstract: We examined the effects of fish oil (FO) on high-cholesterol diet-induced hepatic lipid accumulation and oxidative stress. Female C57BL/6J mice were fed diets consisting of safflower oil (SO), 1 en% FO (1FO), 2 en% FO (2FO), or 20 en% FO (20FO) with or without 2 weight% (wt%) cholesterol (SO/CH, 1FO/CH, 2FO/CH, and 20FO/CH groups, respectively) for 8 weeks. The hepatic triacylglyceride levels were significantly lower in the 2FO/CH and 20FO/CH groups than in the SO/CH group. The hepatic mRNAs of fatty acid oxidation-related genes were upregulated and the fatty acid synthesis-related genes were downregulated by the FO feeding. Adverse effects were not observed in the plasma levels of indicators of oxidative stress in response to the consumption of FO up to 20 en%. These results suggest that FO consumption in the range of 2-20 en% prevents hepatic lipid accumulation, thus improving lipid metabolism without causing oxidative stress.
authors.affiliation: Department of Clinical Dietetics & Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirako
authors.forename: Hyoun Ju
authors.initials: HJ
authors.lastname: Kim
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Iizuka
authors.forename: Maki
authors.initials: M
authors.lastname: Nakasatomi
authors.forename: Akiyo
authors.initials: A
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress; D012450:Safflower Oil / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism
chemical_list: D005395:Fish Oils; D014280:Triglycerides; D012450:Safflower Oil; D002784:Cholesterol