title: Mimosa pudica seed mucilage: isolation; characterization and evaluation as tablet disintegrant and binder.
abstract: In the present study Mimosa pudica seed mucilage was isolated, characterized and evaluated as tablet binder and disintegrant. Several properties of mucilage like high swelling index and gelling nature prompted us to explore its applications as disintegrating and binding agent. Disintegrant properties were evaluated by formulating directly compressed hydrochlorothiazide tablets containing 1%-10% (w/w) of seed mucilage as disintegrant and compared with the standard disintegrants. The disintegration time of mucilage containing tablets was found to be in the order of 3%>1%>5%>7.5%>10%. On comparative evaluation with standard disintegrants, it was observed that the order of disintegration of tablets was Ac-Di-Sol<mucilage (3%, w/w)<corn starch. The results of liquid uptake studies were consistent with the disintegration time studies. The binding and granulating properties of mucilage were evaluated by formulating the paracetamol tablets using the Mimosa mucilage at 6%, 8%, and 10% (w/w) concentration as the binder and compared with tablets prepared using PVP-K25 (1.7%, w/w) and acacia (6.8%, w/w) as the binder. Mimosa mucilage at 10% (w/w) concentration provided tablets with adequate hardness and friability. In conclusion, M. pudica seed mucilage is a potential tablet disintegrant and binder.
authors.affiliation: Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125 001, Haryana, India.
authors.forename: Munish
authors.initials: M
authors.lastname: Ahuja
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.forename: Parvinder
authors.initials: P
authors.lastname: Yadav
authors.forename: Kuldeep
authors.initials: K
authors.lastname: Singh
mesh_terms: D006852:Hydrochlorothiazide / Q000737:chemistry*; D031298:Mimosa / Q000737:chemistry*; D062087:Plant Mucilage / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D013607:Tablets
chemical_list: D062087:Plant Mucilage; D013607:Tablets; D006852:Hydrochlorothiazide