title: Bioactive carbazole alkaloids from Murraya koenigii (L.) Spreng.
abstract: Four new carbazole alkaloids (1-4) and fourteen known carbazole alkaloids (5-18) were isolated from Murraya koenigii. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 4, 6, 16, and 17 (10 μM) had moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage. Compounds 11, 12 and 18 showed significant PTP1B inhibitory activity with IC50 values of 1.773, 1.875 and 2.286 μM, respectively.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. maqinge2010@163.com
authors.forename: Qinge
authors.initials: Q
authors.lastname: Ma
authors.forename: Jin
authors.initials: J
authors.lastname: Tian
authors.forename: Jianbo
authors.initials: J
authors.lastname: Yang
authors.forename: Aiguo
authors.initials: A
authors.lastname: Wang
authors.forename: Tengfei
authors.initials: T
authors.lastname: Ji
authors.forename: Yangai
authors.initials: Y
authors.lastname: Wang
authors.forename: Yalun
authors.initials: Y
authors.lastname: Su
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005688:Galactosamine; D006801:Humans; D020128:Inhibitory Concentration 50; D008099:Liver / Q000187:drug effects*; D015394:Molecular Structure; D032101:Murraya / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*
chemical_list: D000470:Alkaloids; D002227:Carbazoles; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D005688:Galactosamine; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1