title: Addition of nanoscaled bioinspired surface features: A revolution for bone related implants and scaffolds?
abstract: Our expanding ability to handle the "literally invisible" building blocks of our world has started to provoke a seismic shift on the technology, environment and health sectors of our society. During the last two decades, it has become increasingly evident that the "nano-sized" subunits composing many materials—living, natural and synthetic—are becoming more and more accessible for predefined manipulations at the nanosize scale. The use of equally nanoscale sized or functionalised tools may, therefore, grant us unprecedented prospects to achieve many therapeutic aims. In the past decade it became clear that nano-scale surface topography significantly influences cell behaviour and may, potentially, be utilised as a powerful tool to enhance the bioactivity and/ or integration of implanted devices. In this review, we briefly outline the state of the art and some of the current approaches and concepts for the future utilisation of nanotechnology to create biomimetic implantable medical devices and scaffolds for in vivo and in vitro tissue engineering,with a focus on bone. Based on current knowledge it must be concluded that not the materials and surfaces themselves but the systematic biological evaluation of these new material concepts represent the bottleneck for new biomedical product development based on nanotechnological principles.
authors.affiliation: Empa, Swiss Federal Laboratories for Materials Testing and Research, Laboratory for Materials - Biology Interaction, Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland.
authors.forename: Arie
authors.initials: A
authors.lastname: Bruinink
authors.forename: Malak
authors.initials: M
authors.lastname: Bitar
authors.forename: Miriam
authors.initials: M
authors.lastname: Pleskova
authors.forename: Peter
authors.initials: P
authors.lastname: Wick
authors.forename: Harald F
authors.initials: HF
authors.lastname: Krug
authors.forename: Katharina
authors.initials: K
authors.lastname: Maniura-Weber
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes
keywords: Nanotechnology; bone; cell culture; implant; surface design