title: Rhodium-catalyzed conversion of furans to highly functionalized pyrroles.
abstract: The synthesis of highly functionalized pyrroles has been achieved by reaction of rhodium-stabilized imino-carbenes with furans. The reaction features an initial [3+2] annulation to form bicyclic hemiaminals, followed by ring opening to generate trisubstituted pyrroles.
authors.affiliation: Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
authors.forename: Brendan T
authors.initials: BT
authors.lastname: Parr
authors.forename: Samantha A
authors.initials: SA
authors.lastname: Green
authors.forename: Huw M L
authors.initials: HM
authors.lastname: Davies
mesh_terms: D002384:Catalysis; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry*; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
chemical_list: D005663:Furans; D007097:Imines; D011758:Pyrroles; C030011:carbene; D012238:Rhodium; D008697:Methane