title: Association between CASP-8 gene polymorphisms and cancer risk in some Asian population based on a HuGE review and meta-analysis.
abstract: Genetic variation in the CASP-8 gene reportedly can increase cancer susceptibility by regulating tumor cell proliferation and apoptosis. Several studies have investigated this possibility; however, the conclusions remain controversial. We made a Human Genome Epidemiology (HuGE) review and did a meta-analysis to explore the association between CASP-8 gene polymorphisms and cancer risk in Asian populations. Based on the inclusion criteria, 12 case-control studies comprising 7720 cancer cases and 9404 healthy controls were retrieved. Meta-analysis results showed that the rs3834129*del allele/carrier were associated with decreased risk of cancer in Asian populations [del allele: odd ratio (OR) = 0.79, 95% confidence interval (95%CI) = 0.75-0.83, P < 0.001; del carrier: OR = 0.77, 95%CI = 0.72-0.82, P < 0.001]. Subgroup analysis showed that the rs3834129*del allele/carrier are protective factors for cancer risk in Chinese populations (del allele: OR = 0.77, 95%CI = 0.73-0.81, P < 0.001; del carrier: OR = 0.75, 95%CI = 0.70-0.80, P < 0.001), but not in Indian and Korean populations. Furthermore, the rs6704688*T allele/carrier, rs3769827*C allele/carrier, rs3769825*C allele/carrier were associated with decreased risk of cancer in Asian populations (all P < 0.05). While the rs7608692*A allele was associated with increased risk of cancer risk in Asian populations (OR = 1.35, 95%CI = 1.02-1.78, P = 0.03). There was also no significant association between rs3769818, rs13030042, rs13030042, rs1045494, rs1045494, rs2823, or rs113686495, and cancer risk in Asian populations (all P > 0.05). This meta-analysis suggests that the rs3834129*del allele/ carrier, rs6704688*T allele/carrier, rs3769827*C allele/carrier, and rs3769825*C allele/carrier might be protective factors for cancer risk in Asian populations, while the rs7608692*A allele might be a risk factor for cancer risk in Asian populations.
authors.affiliation: Department of General Surgery, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Zhang
authors.forename: X P
authors.initials: XP
authors.lastname: Zhong
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: S R
authors.initials: SR
authors.lastname: Liu
authors.forename: G
authors.initials: G
authors.lastname: Wu
authors.forename: Y F
authors.initials: YF
authors.lastname: Liu
mesh_terms: D017209:Apoptosis / Q000235:genetics; D001208:Asia / Q000453:epidemiology; D053181:Caspase 8 / Q000235:genetics*; D049109:Cell Proliferation; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D053181:Caspase 8