title: Inhibitory effects of maleimide derivatives from the mycelia of the fungus Antrodia cinnamomea BCRC 36799 on nitric oxide production in lipopolysaccharide (LPS)-activated RAW264.7 macrophages.
abstract: Four new maleimide derivatives, antrocinnamomins E-H (1-4, resp.), together with (3S,4R)-1-hydroxy-3-(4-hydroxyphenyl)-4-(2-methylpropyl)pyrrolidine-2,5-dione (5) and ergosterol were isolated from the mycelia of Antrodia cinnamomea BCRC 36799. The structures were elucidated by 1D- and 2D-NMR spectroscopy, and mass spectrometry. Compounds 1-5 were evaluated for their inhibitory effects on nitric oxide (NO) production by macrophages. Compounds 2 and 4 showed stronger inhibition of NO production than the positive control quercetin.
authors.affiliation: Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan. wmd6610@yahoo.com
authors.forename: Ming-Der
authors.initials: MD
authors.lastname: Wu
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Yech
authors.forename: Gwo-Fang
authors.initials: GF
authors.lastname: Yuan
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000818:Animals; D055491:Antrodia / Q000737:chemistry*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008301:Maleimides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D025282:Mycelium / Q000737:chemistry; D009569:Nitric Oxide / Q000378:metabolism*; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology
chemical_list: D008070:Lipopolysaccharides; D008301:Maleimides; C043592:maleimide; D009569:Nitric Oxide; D011794:Quercetin