title: Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride.
abstract: Terbinafine hydrochloride (TH), a poorly water soluble antifungal agent, was characterized by solid state techniques including differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, optical and electron microscopies, Fourier transform infrared, Raman and solid-state nuclear magnetic resonance spectroscopies and intrinsic dissolution rate (IDR). A colorless single crystal of TH was grown from an ethanol:water solution and its crystalline structure was determined through X-ray single crystal diffraction. Also, a new crystal habit of TH was obtained through the slow solvent evaporation technique revealing a needle-like shape. A comparison between the IDR results for the TH raw material and TH needle-like crystal revealed lower values for the new crystal habit, which can be attributed to the preferential orientation of the crystals in the compressed disks.
authors.affiliation: Programa de Pós-graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-970, Brazil. giskuminek@gmail.com
authors.forename: Gislaine
authors.initials: G
authors.lastname: Kuminek
authors.forename: Gabriela Schneider
authors.initials: GS
authors.lastname: Rauber
authors.forename: Manoela Klüppel
authors.initials: MK
authors.lastname: Riekes
authors.forename: Carlos Eduardo Maduro
authors.initials: CE
authors.lastname: de Campos
authors.forename: Gustavo Alberto
authors.initials: GA
authors.lastname: Monti
authors.forename: Adailton João
authors.initials: AJ
authors.lastname: Bortoluzzi
authors.forename: Sílvia Lucia
authors.initials: SL
authors.lastname: Cuffini
authors.forename: Simone Gonçalves
authors.initials: SG
authors.lastname: Cardoso
mesh_terms: D002152:Calorimetry, Differential Scanning; D008855:Microscopy, Electron, Scanning; D009281:Naphthalenes / Q000737:chemistry*; D033362:Powder Diffraction; D012995:Solubility; D013057:Spectrum Analysis; D000077291:Terbinafine
chemical_list: D009281:Naphthalenes; D000077291:Terbinafine