title: A case of rapidly progressive, fatal mycosis fungoides presenting as a haematoma-like lesion.
abstract: Mycosis fungoides usually follows an indolent clinical course. We report here a rapidly progressive case of mycosis fungoides with peculiar clinical and histological features, presenting as a haematoma-like mass on the thigh accompanied by multiple reddish brown erythematous lesions on the trunk and extremities. Histopathologically, the erythematous lesions showed epidermotropism of atypical T lymphocytes expressing CD4 and prominent syringotropism without syringometaplasia. The haematoma-like lesion consisted of diffuse and dense infiltrates of medium-to-large-sized pleomorphic lymphocytic cells expressing CD30, suggesting that CD30+ large-cell transformation had occurred. Mycosis fungoides presenting as a haematoma-like lesion is rare and may be a poor prognostic sign.
authors.affiliation: Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. tohatt@gunma-u.ac.jp.
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Hattori
authors.forename: Akihiko
authors.initials: A
authors.lastname: Uchiyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Tago
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Nagai
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006406:Hematoma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D009182:Mycosis Fungoides / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy; D012867:Skin / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen