title: Silicon multi-nanochannel FETs to improve device uniformity/stability and femtomolar detection of insulin in serum.
abstract: Here we demonstrate the use of multiple Si nanochannel (NC) or nanograting (NG) instead of the conventional single nanochannel or nanowire design in biosensors. The NG devices can significantly reduce device-to-device variation, and improve device performance, e.g. higher current, higher ON/OFF ratio, smaller subthreshold slope, lower threshold voltage Vt in buffer solution. NG devices also result in higher sensor stability in buffer and diluted human serum. We believe such improvements are due to reduced discrete dopant fluctuation in the Si nanowires and biochemical noise in the solution because of the multiple-channel design. The improved devices allow us to sense pH linearly with 3-aminopropyltriethoxysilane coated devices, and to selectively detect insulin with limit of detection down to 10 fM in both buffer solution and diluted human serum without pre-purification.
authors.affiliation: Department of Physics, University of Texas at Dallas Richardson, TX 75080, USA.
authors.forename: Suresh
authors.initials: S
authors.lastname: Regonda
authors.forename: Ruhai
authors.initials: R
authors.lastname: Tian
authors.forename: Jinming
authors.initials: J
authors.lastname: Gao
authors.forename: Serena
authors.initials: S
authors.lastname: Greene
authors.forename: Jiahuan
authors.initials: J
authors.lastname: Ding
authors.forename: Walter
authors.initials: W
authors.lastname: Hu
mesh_terms: D015374:Biosensing Techniques; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000097:blood / Q000302:isolation & purification*; D057230:Limit of Detection; D049329:Nanostructures / Q000737:chemistry*; D053770:Nanowires / Q000737:chemistry; D011437:Propylamines; D012821:Silanes / Q000737:chemistry; D012825:Silicon / Q000737:chemistry
chemical_list: D007328:Insulin; D011437:Propylamines; D012821:Silanes; C477625:amino-propyl-triethoxysilane; D012825:Silicon