title: A New Route to Azafluoranthene Natural Products via Direct Arylation.
abstract: Microwave-assisted direct arylation was successfully employed in the synthesis of azafluoranthene alkaloids for the first time. Direct arylation reactions on a diverse set of phenyltetrahydroisoquinolines produces the indeno[1,2,3-ij]isoquinoline nucleusen routeto a high yielding azafluoranthene synthesis. The method was used as a key step in the efficient preparation of the natural products rufescine and triclisine. As demonstrated herein, this synthetic approach should be generally applicable to the preparation of natural and un-natural azafluoranthene alkaloids as well as "azafluoranthene-like" isoquinoline alkaloids.
authors.affiliation: Chemistry Department, Hunter College, City University of New York, 695 Park Avenue, NY 10065, USA.
authors.forename: Shashikanth
authors.initials: S
authors.lastname: Ponnala
authors.forename: Wayne W
authors.initials: WW
authors.lastname: Harding
keywords: Alkaloid; C-H Activation; Total Synthesis