title: Activity of halogeno-thiazolides against Cryptosporidium parvum in experimentally infected immunosuppressed gerbils (Meriones unguiculatus).
abstract: Nitazoxanide and three halogeno-thiazolides, RM-4850, RM-4865, and RM-5038, were tested against Cryptosporidium parvum in experimentally infected immunosuppressed Mongolian gerbils. Daily 400-mg/kg doses of the four test drugs for 5 to 8 consecutive days produced similar reductions of oocyst shedding. Using early-infected gerbils, a shorter 4-day treatment with RM-5038 reduced oocyst shedding by 95%, compared to 47% for nitazoxanide (P = 0.02), suggesting that RM-5038 is more effective than nitazoxanide under the experimental conditions used.
authors.affiliation: Parasitology Department, Rouen University Hospital & EA 3800, University of Rouen, Rouen, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Gargala
authors.forename: Arnaud
authors.initials: A
authors.lastname: François
authors.forename: Loïc
authors.initials: L
authors.lastname: Favennec
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Rossignol
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D003457:Cryptosporidiosis / Q000188:drug therapy* / Q000469:parasitology; D016785:Cryptosporidium parvum / Q000187:drug effects*; D004195:Disease Models, Animal; D005849:Gerbillinae; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000494:pharmacology; D009574:Nitro Compounds; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000977:Antiparasitic Agents; D007166:Immunosuppressive Agents; D009574:Nitro Compounds; D013844:Thiazoles; C041747:nitazoxanide