title: Association between glucose transporter 1 rs841853 polymorphism and type 2 diabetes mellitus risk may be population specific (1rs8418532).
abstract: BACKGROUND
  So far, studies on the association between the glucose transporter 1 (GLUT1) rs841853 polymorphism and type 2 diabetes mellitus (T2DM) risk have generated considerable controversy. The present study was performed to clarify the association of this genetic variation with T2DM.
  
  
  METHODS
  A comprehensive literature search of electronic databases was conducted to obtain articles focused on the relationship between the GLUT1 rs841853 polymorphism and T2DM, followed by a systemic meta-analysis.
  
  
  RESULTS
  Fourteen articles and 19 individual studies were included for analysis. Main analyses revealed extreme heterogeneity and random effect pooled odds ratios (OR) were weakly significant in allele contrast (OR 1.28; 95% confidence interval [CI] 1.01, 1.63; P=0.04) and dominant model (OR 1.52; 95% CI 1.19, 1.94; P=0.0008) for T allele. Subgroup analyses for Caucasians showed marginal positive results in the dominant model. However, analyses for Asians yielded an obvious relationship to T2DM risk in all genetic models. Interestingly, T allele even seemed to be a protective factor against the development of T2DM in Blacks in allele contrast. Sensitivity analyses did not alter materially for most comparisons and no publication bias was found in this meta-analysis.
  
  
  CONCLUSIONS
  The results of the present meta-analysis provide evidence that the GLUT1 rs841853 polymorphism may confer increased susceptibility to T2DM in Asians. However, there is no currently available strong evidence supporting the association between this genetic variation and T2DM in Caucasians, Blacks, or the overall population.
authors.affiliation: Second Division of the First Hospital, Jilin University, Changchun, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Du
authors.forename: Shengmao
authors.initials: S
authors.lastname: Liu
authors.forename: Chengji
authors.initials: C
authors.lastname: Cui
authors.forename: Songyan
authors.initials: S
authors.lastname: Wang
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Cui
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D051272:Glucose Transporter Type 1 / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D051272:Glucose Transporter Type 1; C495677:SLC2A1 protein, human
keywords: gene polymorphism; glucose transporter 1; meta-analysis; rs841853; type 2 diabetes mellitus; 基因多态性， 对葡萄糖转移酶1，Meta分析，rs841853，2型糖尿病