title: Preservative-free treatment in glaucoma: who, when, and why.
abstract: OBJECTIVE
  To review and summarize the available literature on the effect of preservatives on the eye, to provide practical guidance for the clinical assessment of the ocular surface in glaucoma patients, and to define patient populations that might benefit from preservative-free topical intraocular pressure (IOP)-lowering agents.
  
  
  METHODS
  This manuscript is based on a combination of a literature review on preservatives and the eye and expert opinion from glaucoma specialists with an interest in ocular surface disease.
  
  
  RESULTS
  There is an increasingly recognized association between eyedrop preservatives and ocular surface disease. Preservative-free therapy is now available for a wide range of active compounds, although there are still some misconceptions regarding their appropriate use. For patients treated topically for glaucoma or ocular hypertension, a rough estimate could be that 20% may need treatment with topical IOP-reducing agents that are free from preservatives.
  
  
  CONCLUSIONS
  This review provides an up-to-date account of the literature regarding preservatives and the eye, as well as suggestions and recommendations on to when to use preservative-free antiglaucoma treatment.
authors.affiliation: Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium. ingeborg.stalmans@uzleuven.be
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Stalmans
authors.forename: Gordana
authors.initials: G
authors.lastname: Sunaric Mégevand
authors.forename: M Francesca
authors.initials: MF
authors.lastname: Cordeiro
authors.forename: Anton
authors.initials: A
authors.lastname: Hommer
authors.forename: Luca
authors.initials: L
authors.lastname: Rossetti
authors.forename: Francisco
authors.initials: F
authors.lastname: Goñi
authors.forename: Anders
authors.initials: A
authors.lastname: Heijl
authors.forename: Alain
authors.initials: A
authors.lastname: Bron
mesh_terms: D000959:Antihypertensive Agents / Q000737:chemistry* / Q000627:therapeutic use; D005128:Eye Diseases / Q000139:chemically induced* / Q000517:prevention & control; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D009798:Ocular Hypertension / Q000188:drug therapy*; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical