title: New azalomycin F analogs from mangrove Streptomyces sp. 211726 with activity against microbes and cancer cells.
abstract: Seven new azalomycin F analogs (1-7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F5a monoester (1), 23-valine demalonylazalomycin F5a ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F3a ester (3), F4a ester (4) and F5a ester (5), 23-(9-methyl)decanoic acid demalonylazalomycin F4a ester (6) and 23-(10-methyl)undecanoic acid demalony lazalomycin F4a ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F3a, F4a and F5a. Biological assays exhibited that 1-7 showed broad-spectrum antimicrobial and anti HCT-116 activities.
authors.affiliation: College of Bioscience and Engineering, Jiangxi Agricultural University, 1101 Zhimin Road, Nanchang 330045, China. sqlygj@126.com
authors.forename: Ganjun
authors.initials: G
authors.lastname: Yuan
authors.forename: Kui
authors.initials: K
authors.lastname: Hong
authors.forename: Haipeng
authors.initials: H
authors.lastname: Lin
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
authors.forename: Jia
authors.initials: J
authors.lastname: Li
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D018942:Macrolides; C000232:azalomycin-F