title: Diffusion-weighted imaging to assess treatment response in a child with trilateral retinoblastoma.
abstract: Trilateral retinoblastoma (TRb) is a rare condition in which children with bilateral retinoblastoma develop primary midline intracranial neuroblastic tumors. The intracranial lesions are difficult to follow after treatment due to residual mass-like enhancement that may represent persistent tumor or treated disease. We highlight a case where close evaluation of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) characteristics accurately depicted the extent of treated disease versus residual tumor after chemotherapy.
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Bonci
authors.forename: Marc K
authors.initials: MK
authors.lastname: Rosenblum
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Gilheeney
authors.forename: Ira J
authors.initials: IJ
authors.lastname: Dunkel
authors.forename: Andrei I
authors.initials: AI
authors.lastname: Holodny
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D012175:Retinoblastoma / Q000175:diagnosis* / Q000628:therapy*; D013577:Syndrome; D016896:Treatment Outcome