title: Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2.
abstract: The molecular mechanism to regulate energy balance is not completely understood. Here we observed that Egr-1 expression in white adipose tissue (WAT) was highly correlated with dietary-induced obesity and insulin resistance both in mice and humans. Egr-1 null mice were protected from diet-induced obesity and obesity-associated pathologies such as fatty liver, insulin resistance, hyperlipidemia and hyperinsulinemia. This phenotype can be largely explained by the increase of energy expenditure in Egr-1 null mice. Characterization of these mice revealed that the expression of FOXC2 and its target genes were significantly elevated in white adipose tissues, leading to WAT energy expenditure instead of energy storage. Altogether, these studies suggest an important role for Egr-1, which, by repressing FOXC2 expression, promotes energy storage in WAT and favored the development of obesity under high energy intake.
authors.affiliation: Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, MSRB III 7301E, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tingwan
authors.initials: T
authors.lastname: Sun
authors.forename: Fang
authors.initials: F
authors.lastname: Guo
authors.forename: Shengping
authors.initials: S
authors.lastname: Huang
authors.forename: Menisha
authors.initials: M
authors.lastname: Chandalia
authors.forename: Nicola
authors.initials: N
authors.lastname: Abate
authors.forename: Daping
authors.initials: D
authors.lastname: Fan
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Xin
authors.forename: Y Eugene
authors.initials: YE
authors.lastname: Chen
authors.forename: Mingui
authors.initials: M
authors.lastname: Fu
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D004032:Diet; D051766:Early Growth Response Protein 1 / Q000235:genetics*; D004734:Energy Metabolism; D051858:Forkhead Transcription Factors / Q000235:genetics*; D007333:Insulin Resistance; D051379:Mice; D018345:Mice, Knockout; D009765:Obesity / Q000209:etiology / Q000235:genetics* / Q000517:prevention & control
chemical_list: D051766:Early Growth Response Protein 1; C486109:Egr1 protein, mouse; D051858:Forkhead Transcription Factors; C082078:mesenchyme fork head 1 protein