title: Non-classical anticancer agents: on the way to water soluble zinc(II) heteroleptic complexes.
abstract: Two new heteroleptic Zn(II) complexes of the 4,4'-bis(hydroxymethyl)-2,2'-bipyridine have been synthesized by using different stoichiometric ratios of tropolone. In an attempt to induce the formation of metal complex co-crystals, liquid assisted solid state reaction followed by solvent crystallization has been conducted by using the new Zn(II) tropolonate derivatives 1 and 2 with saccharin. The novel Zn(II) species obtained exhibits different structures and properties with respect to their precursors, due to a hydrogen exchange between saccharin and the tropolonate coordinated ligand.
authors.affiliation: Centro di Eccellenza CEMIF.CAL, LASCAMM CR-INSTM and Laboratorio Regionale Licryl, CNR-INFM, Dipartimento di Chimica, Università della Calabria, 87030 Arcavacata di Rende (CS), Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Sanz Mendiguchia
authors.forename: Daniela
authors.initials: D
authors.lastname: Pucci
authors.forename: Teresa F
authors.initials: TF
authors.lastname: Mastropietro
authors.forename: Mauro
authors.initials: M
authors.lastname: Ghedini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Crispini
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D012439:Saccharin / Q000737:chemistry; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D014867:Water; D015082:2,2'-Dipyridyl; D012439:Saccharin; D015032:Zinc