title: [Comparative experimental assessment of the impact of gold and silver nanoparticles on the phagocyting cells of the lower airways].
abstract: Judging by the cytological characteristics of the free cell population of the lower airways obtained with assistance of the bronchoalveolar lavage in 24 hours after the intratracheal instillation of equal doses of equidimensional gold or silver nanoparticles, both metals result in active recruitment of phagocytes with domination of neutrophile leukocytes, especially marked after the instillation of the nanosilver. The higher ratio of these cells count to that of alveolar macrophages gives evidence for the significantly higher cytotoxicity of the nanosilver comparing with both nanogold and even the smallest silver particles in the micrometric range. Transmission electron microscopy demonstrates similar pictures of intracellular distribution and ultra-structural damages caused by internalized nanoparticles in both types of phagocytes, while there are significant differences between cells under impact of nanosilver vs. those under impact of nanogold. The highest importance is higher propensity of the nanosilver particles to aggregation and to ingression into mitochondria with damaging these organelles.
authors.forename: L I
authors.initials: LI
authors.lastname: Privalova
authors.forename: M P
authors.initials: MP
authors.lastname: Sutunkova
authors.forename: S V
authors.initials: SV
authors.lastname: Pichugova
authors.forename: B A
authors.initials: BA
authors.lastname: Katsnel'son
authors.forename: L G
authors.initials: LG
authors.lastname: Tulakina
authors.forename: Ia B
authors.initials: IaB
authors.lastname: Beĭkin
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Shur
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002452:Cell Count / Q000379:methods; D003603:Cytotoxins / Q000633:toxicity; D005260:Female; D006046:Gold / Q000008:administration & dosage / Q000633:toxicity; D007322:Instillation, Drug; D008262:Macrophage Activation / Q000187:drug effects*; D016676:Macrophages, Alveolar / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000633:toxicity; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D012834:Silver / Q000008:administration & dosage / Q000633:toxicity; D013997:Time Factors
chemical_list: D003603:Cytotoxins; D012834:Silver; D006046:Gold