title: High C reactive protein associated with increased pulse wave velocity among urban men with metabolic syndrome in Malaysia.
abstract: OBJECTIVE
  To determine the association between carotid femoral pulse wave velocity (PWVCF); augmentation index (AI); and high-sensitivity C reactive protein (hs-CRP) with metabolic syndrome (MetS), and to determine the influence of ethnicity on PWVCF and AI, and the association between high hs-CRP and increased PWV, and AI in MetS.
  
  
  METHODS
  A cross-sectional study was conducted at Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia from September 2009 to September 2011. Three hundred and eighty men (Chinese and Malays) were recruited from the study. The PWVCF and AI were measured by Vicorder (SMT Medical, Wuerzburg, Germany). The hs-CRP level was also determined. We defined MetS using the International Diabetes Federation (IDF) and harmonized criteria.
  
  
  RESULTS
  Malays had higher AI compared to the Malaysian Chinese. Patients with MetS had higher PWVCF (IDF criteria: 8.5 [8.3-8.7] versus 8.2 [8.0-8.4] m/s, p=0.03; harmonized criteria: 8.5 [8.4-8.7] versus 8.2 [8.0-8.4] m/s, p=0.007) and hs-CRP (IDF criteria: 0.9+/-2.0 versus 0.4+/-1.1 mg/L, p=0.0007; harmonized criteria: 0.8+/-1.9 versus 0.4+/-1.1 mg/L, p=0.002) compared to non-MetS. In subjects with MetS, those with high hs-CRP (>3 mg/L) had higher PWVCF.
  
  
  CONCLUSIONS
  Augmentation index values were significantly higher in Malays compared with Malaysian Chinese. Metabolic syndrome was associated with increased PWVCF and hs-CRP. Patients with MetS and high hs-CRP were associated with higher PWVCF. The measurement of hs-CRP reflects the degree of subclinical vascular damage in MetS.
authors.affiliation: Department of Physiology, Universiti Kebangsaan Malaysia Medical Center, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.
authors.forename: Amilia
authors.initials: A
authors.lastname: Aminuddin
authors.forename: Zaiton
authors.initials: Z
authors.lastname: Zakaria
authors.forename: Ahmad F
authors.initials: AF
authors.lastname: Fuad
authors.forename: Jaarin
authors.initials: J
authors.lastname: Kamsiah
authors.forename: Faizah
authors.initials: F
authors.lastname: Othman
authors.forename: Srijit
authors.initials: S
authors.lastname: Das
authors.forename: Yusof
authors.initials: Y
authors.lastname: Kamisah
authors.forename: Haji S
authors.initials: HS
authors.lastname: Qodriyah
authors.forename: Zakiah
authors.initials: Z
authors.lastname: Jubri
authors.forename: Nor Anita M
authors.initials: NA
authors.lastname: Nordin
authors.forename: Wan Z
authors.initials: WZ
authors.lastname: Ngah
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D006801:Humans; D008296:Malaysia; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000503:physiopathology; D012307:Risk Factors; D014505:Urban Population; D059289:Vascular Stiffness
chemical_list: D002097:C-Reactive Protein