title: [Differential diagnosis of lymphoid infiltrates in the central nervous system: experience of the Network Lymphomas and Lymphomatoid Lesions in the Nervous System].
abstract: The differential diagnosis of lymphoid lesions in the central nervous system covers a broad spectrum of neoplastic and inflammatory disorders. Complex cases benefit from the combined expertise in the fields of hematopoietic and neuroepithelial tumors as well as neuroimmunology. The Network Lymphomas and Lymphomatoid Lesions in the Nervous System (NLLLN) recommends performing a biopsy prior to any therapeutic intervention as a precise diagnosis was impossible in approximately 50 % of patients pretreated with corticosteroids. This is based on the analysis of approximately 1,000 cases in the past 4 years. In addition to total NLLLN experiences the characteristics, pathogenesis and differential diagnosis of primary lymphoma of the central nervous system are discussed.
authors.affiliation: Institut für Neuropathologie, Universitätsmedizin Göttingen, Georg-August-Universität, Göttingen, Deutschland.
authors.forename: W
authors.initials: W
authors.lastname: Brück
authors.forename: A
authors.initials: A
authors.lastname: Brunn
authors.forename: W
authors.initials: W
authors.lastname: Klapper
authors.forename: T
authors.initials: T
authors.lastname: Kuhlmann
authors.forename: I
authors.initials: I
authors.lastname: Metz
authors.forename: W
authors.initials: W
authors.lastname: Paulus
authors.forename: M
authors.initials: M
authors.lastname: Deckert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D001706:Biopsy; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000235:genetics / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000235:genetics; D019310:Pseudolymphoma / Q000235:genetics / Q000473:pathology*; D011947:Receptors, Antigen, B-Cell / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D016328:NF-kappa B; D011947:Receptors, Antigen, B-Cell