title: The role of soluble CD40L in immunosuppression.
abstract: We have recently performed the first comprehensive study of the potential immunosuppressive role of soluble CD40L (sCD40L). In addition, we demonstrated that serum sCD40L can potentially be used as an indicator of response to anticancer therapy, and/or to better identify those patients who would have best chances to benefit from tumor-targeting vaccines or other therapeutic modalities.
authors.affiliation: Laboratory of Tumor Immunology and Biology; Center for Cancer Research; National Cancer Institute; National Institutes of Health; Bethesda, MD USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Schlom
authors.forename: Caroline
authors.initials: C
authors.lastname: Jochems
authors.forename: James L
authors.initials: JL
authors.lastname: Gulley
authors.forename: Jianping
authors.initials: J
authors.lastname: Huang
keywords: immunosuppression; myeloid derived suppressor cells (MDSC); regulatory T cells (Tregs); sCD40L; vaccine therapy