title: F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis.
abstract: Primary meningeal melanomatosis is a rare, aggressive variant of primary malignant melanoma of the central nervous system, which arises from melanocytes within the leptomeninges and carries a poor prognosis. We report a case of primary meningeal melanomatosis in a 17-year-old man, which was diagnosed with (18)F-fluorodeoxyglucose (F-18 FDG) PET/CT, and post hoc F-18 FDG PET/MRI fusion images. Whole-body F-18 FDG PET/CT was helpful in ruling out the extracranial origin of melanoma lesions, and in assessing the therapeutic response. Post hoc PET/MRI fusion images facilitated the correlation between PET and MRI images and demonstrated the hypermetabolic lesions more accurately than the unenhanced PET/CT images. Whole body F-18 FDG PET/CT and post hoc PET/MRI images might help clinicians determine the best therapeutic strategy for patients with primary meningeal melanomatosis.
authors.affiliation: Department of Nuclear Medicine, Dongnam Institute of Radiological & Medical Sciences, Busan 619-953, Korea.
authors.forename: Hong Je
authors.initials: HJ
authors.lastname: Lee
authors.forename: Byeong-Cheol
authors.initials: BC
authors.lastname: Ahn
authors.forename: Seong Wook
authors.initials: SW
authors.lastname: Hwang
authors.forename: Suk Kyong
authors.initials: SK
authors.lastname: Cho
authors.forename: Hae Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Lee
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Hwang
authors.forename: Jaetae
authors.initials: J
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: F-18 FDG; Meningeal melanomatosis; PET/CT; post hoc PET/MRI