title: Clinical outcomes of patients with salivary gland carcinomas preoperatively misdiagnosed as benign lesions.
abstract: BACKGROUND
  We compared clinical outcomes between patients with salivary gland carcinomas preoperatively misdiagnosed as benign lesion and properly diagnosed as malignant lesion.
  
  
  METHODS
  The outcomes were compared between patients with benign lesion and malignant lesion (44 each) on preoperative fine-needle aspiration cytology diagnosis who underwent conservative or radical surgery.
  
  
  RESULTS
  Five-year lesion-free survival (DFS) rates were 86.8% for benign lesion and 76.3% for malignant lesion (p = .128). Surgical extent did not significantly affect locoregional recurrence and DFS (p = .360). Univariate analysis showed that sublingual gland tumor, positive resection margin, and extraparenchymal extension (EPE) were significantly associated with DFS (p < .05 each). On multivariate analysis, EPE remained an independent variable (p = .047, hazard ratio = 6.621, 95% confidence interval = 1.393-31.474).
  
  
  CONCLUSIONS
  The clinical outcomes of patients with salivary gland carcinomas misdiagnosed as benign are relatively favorable. Conservative surgery may be sufficient for patients with low-grade and T1-2 salivary gland carcinomas.
authors.affiliation: Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: In Sun
authors.initials: IS
authors.lastname: Ryu
authors.forename: Jong-Lyel
authors.initials: JL
authors.lastname: Roh
authors.forename: Kyung-Ja
authors.initials: KJ
authors.lastname: Cho
authors.forename: Sang-wook
authors.initials: SW
authors.lastname: Lee
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Soon Yuhl
authors.initials: SY
authors.lastname: Nam
authors.forename: Sang Yoon
authors.initials: SY
authors.lastname: Kim
mesh_terms: D008949:Adenoma, Pleomorphic / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D002277:Carcinoma / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D003951:Diagnostic Errors; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local; D057234:Preoperative Period; D018714:Radiotherapy, Adjuvant; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery*; D012469:Salivary Glands / Q000473:pathology / Q000601:surgery; D055815:Young Adult
keywords: diagnosis; outcomes; preoperative cytology; recurrence; salivary gland carcinomas