title: Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica.
abstract: OBJECTIVE
  Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their anti-inflammatory, antipruritic and mast cell stabilizing activity.
  
  
  METHODS
  Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound 48/80 and sheep serum induced mast cell degranulation methods.
  
  
  RESULTS
  The ethanol extract (300 mg/kg) and petroleum ether extract (100 mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (69%) by compound 48/80 model. In sheep serum model the ethanol extracts (150 and 300 mg/kg) and petroleum ether extract (100 mg/kg) showed good mast cell stabilizing activity (66-67%). Ethanol extract at 150 mg/kg showed 70% reduction of rat paw oedema and also significantly reduced the scratching response.
  
  
  CONCLUSIONS
  Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity.
authors.affiliation: Department of Pharmaceutical Chemistry, MCOPS, Manipal University, Karnataka, India.
authors.forename: Jessy Elizabeth
authors.initials: JE
authors.lastname: Mathew
authors.forename: Srinivasan Keloth
authors.initials: SK
authors.lastname: Kaitheri
authors.forename: Seekarajapuram
authors.initials: S
authors.lastname: Dinakaranvachala
authors.forename: Magi
authors.initials: M
authors.lastname: Jose
keywords: Anti-antipruritic; Anti-inflammatory; Aristolochia indica; Mast cell stabilizing activity