title: The effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats.
abstract: OBJECTIVE
  Cytokines such as IL-1β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1β after traumatic brain injury (TBI) in male rats.
  
  
  METHODS
  Rats were assigned into 6 groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations were quantified by ELISA kits.
  
  
  RESULTS
  Groups showed no significant difference in brain IL-10 either after TBI induction or after treatment with ibuprofen or celecoxib. Serum IL-10 in vehicle or ibuprofen treated animals was lower than in sham groups (P< 0.01). Brain IL-1β decreased after treatment by ibuprofen or celecoxib (P< 0.001). There was no statistical difference in serum IL-1β in TBI and intact. Serum IL-1β significantly decreased in rats that received celecoxib compared to TBI group (P< 0.01).
  
  
  CONCLUSIONS
  Based on our study IL-1β can decrease through both cyclooxygenase 1 (COX-1) and COX-2 pathway but serum IL-1β can decrease only by COX-2 pathway.
authors.affiliation: North Khorasan University of Medical Sciences, Bojnord, Iran.
authors.forename: Zakieh
authors.initials: Z
authors.lastname: Keshavarzi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khaksari
authors.forename: Zohre
authors.initials: Z
authors.lastname: Razmi
authors.forename: Ava
authors.initials: A
authors.lastname: Soltani Hekmat
authors.forename: Vida
authors.initials: V
authors.lastname: Naderi
authors.forename: Sima
authors.initials: S
authors.lastname: Rostami
keywords: Brain injury; Celecoxib; Ibuprofen; Interleukin-10