title: Mast cells and the liver aging process.
abstract: It has now ascertained that the clinical manifestations of liver disease in the elderly population reflect both the cumulative effects of longevity on the liver and the generalized senescence of the organism ability to adjust to metabolic, infectious, and immunologic insults. Although liver tests are not significantly affected by age, the presentation of liver diseases such as viral hepatitis may be subtler in the elderly population than that of younger patients.Human immunosenescence is a situation in which the immune system, particularly T lymphocyte function, deteriorates with age, while innate immunity is negligibly affected and in some cases almost up-regulated.We here briefly review the relationships between the liver aging process and mast cells, the key effectors in a more complex range of innate immune responses than originally though.
authors.affiliation: Laboratory of Molecular Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Grizzi
authors.affiliation: Laboratory of Molecular Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Caro
authors.affiliation: Laboratory of Molecular Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Laghi
authors.affiliation: Department of Internal medicine and Gene Therapy Program, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Hermonat
authors.affiliation: Department of Health Sciences, University of Milano-Bicocca, Milan, and Geriatric Clinic, San Gerardo Hospital, Monza, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Mazzola
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
authors.forename: Diane D
authors.initials: DD
authors.lastname: Nguyen
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
authors.forename: Saba
authors.initials: S
authors.lastname: Radhi
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Figueroa
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.|The Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
authors.forename: Everardo
authors.initials: E
authors.lastname: Cobos
authors.affiliation: Department of Health Sciences, University of Milano-Bicocca, Milan, and Geriatric Clinic, San Gerardo Hospital, Monza, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Annoni
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.|The Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Texas Tech University Health Sciences Center, Amarillo, TX, USA.|Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Chiriva-Internati