title: Copy number variation in the autism genome.
abstract: BACKGROUND
  Autism spectrum disorders (ASDs) are among the most heritable of all neurodevelopmental disorders. Despite intense research there has been limited success in deciphering the etiology of ASDs.
  
  
  OBJECTIVE
  It has been shown that chromosomal rearrangements play an important role in ASDs. The recent development of techniques to screen the genome for genetic variation at ever-higher resolution has led to some crucial discoveries over the last year. This progress is described and discussed.
  
  
  METHODS
  This review provides an overview of genetic variation studies in ASD, with a focus on structural genetic variation.
  
  
  CONCLUSIONS
  Screening for copy number variation is an important approach in ASD research. With the introduction of next-generation sequencing, the pace of ASD genetics will increase in the near future.
authors.affiliation: The Hospital for Sick Children, Program in Genetics and Genome Biology, 101 College Street, MaRS - East Tower, Rm 14-701, Toronto, ON M5G 1L7, Canada +1 416 813 7654 ext 1358 ; +1 416 813 8319 ; lfeuk@sickkids.ca.
authors.forename: Lars
authors.initials: L
authors.lastname: Feuk