title: Predictors of alcohol dependence relapse during recurrence of major depression.
abstract: This study sought to determine clinical predictors of alcohol relapse during recurrence of major depression. The total sample included 2,820 adults with a history of alcohol dependence who had a comorbid current episode of major depression. Twenty-six percent had a relapse of alcohol dependence. Relapsers were more likely to be male, single, less educated, and younger than non-relapsers. Early onset alcohol dependence and past year drug use disorder significantly increased the likelihood of relapse. Early onset substance use dependence is a more powerful predictor of alcohol relapse than early onset major depression.
authors.affiliation: Depression Evaluation Service, New York State Psychiatric Institute, New York, New York 10032, USA. agostiv@pi.cpmc.columbia.edu
authors.forename: Vito
authors.initials: V
authors.lastname: Agosti
mesh_terms: D000328:Adult; D017668:Age of Onset; D000437:Alcoholism / Q000453:epidemiology*; D000987:Antisocial Personality Disorder / Q000453:epidemiology; D001008:Anxiety Disorders / Q000453:epidemiology; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000453:epidemiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D018450:Disease Progression; D005260:Female; D006306:Health Surveys / Q000706:statistics & numerical data; D006801:Humans; D007406:Interview, Psychological; D016015:Logistic Models; D008297:Male; D012008:Recurrence; D012307:Risk Factors; D017678:Sex Distribution; D019966:Substance-Related Disorders / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology; D055815:Young Adult