title: Ineffectiveness of crizotinib on brain metastases in two cases of lung adenocarcinoma with EML4-ALK rearrangement.
authors.affiliation: Centre Léon Bérard, Lyon Cedex, France. denismaillet07@gmail.com
authors.forename: Denis
authors.initials: D
authors.lastname: Maillet
authors.forename: Isabelle
authors.initials: I
authors.lastname: Martel-Lafay
authors.forename: Dominique
authors.initials: D
authors.lastname: Arpin
authors.forename: Maurice
authors.initials: M
authors.lastname: Pérol
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D000077547:Crizotinib; D015321:Gene Rearrangement; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000037:antagonists & inhibitors / Q000235:genetics*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011720:Pyrazoles / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: C522504:EML4-ALK fusion protein, human; D015514:Oncogene Proteins, Fusion; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib