title: Oral soft-tissue angiolipoma: report of two cases of rare oral lipomatous lesion with emphasis on morphological and immunohistochemical features.
abstract: Oral angiolipomas are exceedingly rare and little is known about their morphological and etiological features. Here, we report two cases of oral angiolipoma and discuss their clinicopathological and immunohistochemical features, focusing on endothelial markers. Both lesions presented mature adipocytes interspersed by small blood vessels containing fibrin thrombi. Immunohistochemical analysis showed numerous mast cells and expression of CD34, vascular endothelial growth factor, intercellular adhesion molecule-1, interferon-γ and interleukin 6 in most endothelial and stromal cells. Mast cell-endothelial cell interaction may be responsible for the reactive or neoplastic origin of the vascular proliferation of these entities.
authors.affiliation: Department of Stomatology, School of Dentistry, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Geraldo O
authors.initials: GO
authors.lastname: Silva-Junior
authors.forename: Bruna L
authors.initials: BL
authors.lastname: Picciani
authors.forename: Raphael C
authors.initials: RC
authors.lastname: Costa
authors.forename: Saulo M
authors.initials: SM
authors.lastname: Barbosa
authors.forename: Marcelo G
authors.initials: MG
authors.lastname: Silvares
authors.forename: Ramiro B
authors.initials: RB
authors.lastname: Souza
authors.forename: Marília H
authors.initials: MH
authors.lastname: Cantisano
authors.forename: Fabio R
authors.initials: FR
authors.lastname: Pires
mesh_terms: D017667:Adipocytes / Q000473:pathology; D000328:Adult; D018206:Angiolipoma / Q000473:pathology*; D018952:Antigens, CD34 / Q000032:analysis; D042783:Endothelial Cells / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D005337:Fibrin / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D007371:Interferon-gamma / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D008407:Mast Cells / Q000473:pathology; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology; D013927:Thrombosis / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D015850:Interleukin-6; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma; D005337:Fibrin