title: Cognition assessment using the NIH Toolbox.
abstract: Cognition is 1 of 4 domains measured by the NIH Toolbox for the Assessment of Neurological and Behavioral Function (NIH-TB), and complements modules testing motor function, sensation, and emotion. On the basis of expert panels, the cognition subdomains identified as most important for health, success in school and work, and independence in daily functioning were Executive Function, Episodic Memory, Language, Processing Speed, Working Memory, and Attention. Seven measures were designed to tap constructs within these subdomains. The instruments were validated in English, in a sample of 476 participants ranging in age from 3 to 85 years, with representation from both sexes, 3 racial/ethnic categories, and 3 levels of education. This report describes the development of the Cognition Battery and presents results on test-retest reliability, age effects on performance, and convergent and discriminant construct validity. The NIH-TB Cognition Battery is intended to serve as a brief, convenient set of measures to supplement other outcome measures in epidemiologic and longitudinal research and clinical trials. With a computerized format and national standardization, this battery will provide a "common currency" among researchers for comparisons across a wide range of studies and populations.
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern Feinberg School of Medicine, Chicago, IL, USA. sweintraub@northwestern.edu
authors.forename: Sandra
authors.initials: S
authors.lastname: Weintraub
authors.forename: Sureyya S
authors.initials: SS
authors.lastname: Dikmen
authors.forename: Robert K
authors.initials: RK
authors.lastname: Heaton
authors.forename: David S
authors.initials: DS
authors.lastname: Tulsky
authors.forename: Philip D
authors.initials: PD
authors.lastname: Zelazo
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Bauer
authors.forename: Noelle E
authors.initials: NE
authors.lastname: Carlozzi
authors.forename: Jerry
authors.initials: J
authors.lastname: Slotkin
authors.forename: David
authors.initials: D
authors.lastname: Blitz
authors.forename: Kathleen
authors.initials: K
authors.lastname: Wallner-Allen
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Fox
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Beaumont
authors.forename: Dan
authors.initials: D
authors.lastname: Mungas
authors.forename: Cindy J
authors.initials: CJ
authors.lastname: Nowinski
authors.forename: Jennifer
authors.initials: J
authors.lastname: Richler
authors.forename: Joanne A
authors.initials: JA
authors.lastname: Deocampo
authors.forename: Jacob E
authors.initials: JE
authors.lastname: Anderson
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Manly
authors.forename: Beth
authors.initials: B
authors.lastname: Borosh
authors.forename: Richard
authors.initials: R
authors.lastname: Havlik
authors.forename: Kevin
authors.initials: K
authors.lastname: Conway
authors.forename: Emmeline
authors.initials: E
authors.lastname: Edwards
authors.forename: Lisa
authors.initials: L
authors.lastname: Freund
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: King
authors.forename: Claudia
authors.initials: C
authors.lastname: Moy
authors.forename: Ellen
authors.initials: E
authors.lastname: Witt
authors.forename: Richard C
authors.initials: RC
authors.lastname: Gershon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001288:Attention / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000503:physiopathology; D006801:Humans; D007802:Language; D008875:Middle Aged; D009316:National Institutes of Health (U.S.); D009483:Neuropsychological Tests / Q000592:standards*; D015203:Reproducibility of Results; D014481:United States; D055815:Young Adult