title: Anti-obesity effect and action mechanism of Adenophora triphylla root ethanol extract in C57BL/6 obese mice fed a high-fat diet.
abstract: This study investigated the anti-obesity effect of Adenophora triphylla root ethanol extract (ATREE). C57BL/6 mice were divided into five groups, a normal diet group (N), a control group fed only high-fat diet (HFD) (C), a positive control group fed HFD with 0.5% catechin (PC), and groups fed HFD with 0.5% (E1) or 1% (E2) ATREE. The body weight gain, hematological and serum biochemistry data, and anti-oxidative index in the liver and epididymal adipose tissue were improved significantly in the E group (E1, E2), as compared to the C group. As for histological findings, adipocyte size was reduced by ATREE. E group (E1, E2) showed significant increases in adiponectin, AMPK, and PPAR-α, and significant decreases in TNF-α, GPDH, and PPAR-γ, as compared to the C group. The above findings indicate that ATREE might have an anti-obesity effect through antioxidant and anti-inflammatory action. It is considered ATREE can be used as a natural treatment for obesity and metabolic syndrome induced by oxidative stress.
authors.affiliation: Department of Public Health, Keimyung University, Daegu, Republic of Korea.
authors.forename: Seong-Eun
authors.initials: SE
authors.lastname: Lee
authors.forename: Eun-Hei
authors.initials: EH
authors.lastname: Lee
authors.forename: Tae-Jong
authors.initials: TJ
authors.lastname: Lee
authors.forename: Seung-Won
authors.initials: SW
authors.lastname: Kim
authors.forename: Bae-Hwan
authors.initials: BH
authors.lastname: Kim
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000821:Animal Feed; D000818:Animals; D019440:Anti-Obesity Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D029422:Campanulaceae / Q000737:chemistry*; D059305:Diet, High-Fat / Q000009:adverse effects*; D004326:Drinking / Q000187:drug effects; D000431:Ethanol / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D019440:Anti-Obesity Agents; D000975:Antioxidants; D010936:Plant Extracts; D000431:Ethanol