title: Kinetics of cisplatin release by in-vitro using poly(D,L-lactide) coated Fe3O4 nanocarriers.
abstract: Applications of nanoparticles as drug delivery systems for anticancer therapeutics have great potential to revolutionize the future of cancer therapy. In the present study, Fe3O4 nanoparticles were synthesized by co-precipitation method in the alkaline pH medium. The synthesized nanoparticles were characterized by X-ray diffraction and high resolution scanning electron microscope techniques. These analyses reveal the formation of agglomerated single phase Fe3O4 nanoparticles with average crystallite size of 8 nm. The emulsification solvent evaporation method was employed to prepare anti-cancer drug cisplatin loaded biodegradable poly (D, L-lactide) coated magnetic carriers. Fourier transform infrared spectroscopy shows the presence of cisplatin loaded poly(D,L-lactide) coating on the surface of Fe3O4 nanoparticles. Cisplatin loading efficiency and kinetics of drug release in-vitro were investigated by UV-Vis spectrophotometer. The loading efficiency of the drug was found to be 80% and from that 53% of the drug was released over a period of 70 h in phosphate buffer saline (pH 7.4) at ~ 37°C.
authors.affiliation: Department of Medical Bionanotechnology, Chettinad Hospital and Research Institute, Kelambakkam, India. vimaladevi17@gmail.com
authors.forename: S Vimala
authors.initials: SV
authors.lastname: Devi
authors.forename: T
authors.initials: T
authors.lastname: Prakash
mesh_terms: D002945:Cisplatin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D007700:Kinetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D011091:Polyesters; C033616:poly(lactide); D002945:Cisplatin