title: Novel ternary vanadium-betaine-peroxido species suppresses H-ras and matrix metalloproteinase-2 expression by increasing reactive oxygen species-mediated apoptosis in cancer cells.
abstract: Vanadium is known for its antitumorigenicity. Poised to investigate the impact of well-defined forms of vanadium on processes and specific biomolecules (oncogenes-proteins) involved in cancer cell physiology, a novel ternary V(V)-peroxido-betaine compound was employed in experiments targeting cell viability, apoptosis, reactive oxygen species (ROS) production, H-ras signaling, and matrix metalloproteinase-2 (MMP-2) expression in human breast cancer epithelial and lung adenocarcinoma cells. The results reveal that vanadium imparts a significant decrease in cancer cell viability, reducing H-ras and MMP-2 expression by increasing ROS-mediated apoptosis, distinctly emphasizing the nature, structure and properties of ternary ligands on vanadium anti-tumor activity and its future potential as a metallodrug.
authors.affiliation: Laboratory of Inorganic Chemistry, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
authors.forename: Savvas
authors.initials: S
authors.lastname: Petanidis
authors.forename: Efrosini
authors.initials: E
authors.lastname: Kioseoglou
authors.forename: Margarita
authors.initials: M
authors.lastname: Hadzopoulou-Cladaras
authors.forename: Athanasios
authors.initials: A
authors.lastname: Salifoglou
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000077192:Adenocarcinoma of Lung; D017209:Apoptosis / Q000187:drug effects; D001622:Betaine / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D061986:MCF-7 Cells; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis / Q000187:drug effects / Q000378:metabolism; D010545:Peroxides / Q000737:chemistry / Q000494:pharmacology*; D016283:Proto-Oncogene Proteins p21(ras) / Q000096:biosynthesis / Q000187:drug effects / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D014639:Vanadium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010545:Peroxides; D017382:Reactive Oxygen Species; D014639:Vanadium; D001622:Betaine; D020778:Matrix Metalloproteinase 2; D016283:Proto-Oncogene Proteins p21(ras)