title: A perfect time to harness advanced molecular technologies to explore the fundamental biology of Toxocara species.
abstract: Toxocarosis is of major canine health and socioeconomic importance worldwide. Although many studies have given insights into toxocarosis, to date, there has been limited exploration of the molecular biology, biochemistry, genetics, epidemiology and ecology of Toxocara species as well as parasite-host interactions using '-omic' technologies. The present article gives a background on Toxocara species and toxocarosis, describes molecular tools for specific identification and genetic analysis, and provides a prospective view of the benefits that advanced molecular technologies will have towards better understanding the parasites and disease. Tackling key biological questions employing a 'systems biology' approach should lead to new and improved strategies for the treatment, diagnosis and control of toxocarosis.
authors.affiliation: Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010, Australia. robinbg@unimelb.edu.au
authors.forename: Robin B
authors.initials: RB
authors.lastname: Gasser
mesh_terms: D000818:Animals; D019295:Computational Biology; D004285:Dogs; D050259:Genes, Mitochondrial / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation; D005828:Genetics, Population; D006790:Host-Parasite Interactions; D006801:Humans; D008967:Molecular Biology; D011634:Public Health; D049490:Systems Biology; D014119:Toxocara / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D017166:Toxocara canis / Q000235:genetics / Q000276:immunology / Q000502:physiology; D014120:Toxocariasis / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology*; D015047:Zoonoses
chemical_list: D005819:Genetic Markers