title: Dynamic multivalency for carbohydrate-protein recognition through dynamic combinatorial libraries based on Fe(II)-bipyridine complexes.
abstract: Molecular recognition: Dynamic combinatorial libraries (DCLs) exploiting multivalency effects and metal coordination have been employed for carbohydrate-protein recognition. The interaction of a three-component DCL based on 2,2'-bipyridine (bipy)-Fe(II) complexes with concanavalin A (ConA; see scheme) results in enhanced binding by multivalent presentation with a bias towards mannose-containing library components.
authors.affiliation: The Institute of Chemical Research of Catalonia (ICIQ), Avda. Països Catalans 16, 43007-Tarragona, Spain.
authors.forename: Philipp
authors.initials: P
authors.lastname: Reeh
authors.forename: Javier
authors.initials: J
authors.lastname: de Mendoza
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D003208:Concanavalin A / Q000737:chemistry / Q000378:metabolism; D005296:Ferrous Compounds / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry*; D015394:Molecular Structure; D011506:Proteins / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D005296:Ferrous Compounds; D011506:Proteins; D003208:Concanavalin A; D015082:2,2'-Dipyridyl; D008358:Mannose