title: Melanoma metastases in the abdomen and pelvis: Frequency and patterns of spread.
abstract: OBJECTIVE
  To investigate the frequency, typical and atypical locations and patterns of melanoma metastases identifiable by computed tomography (CT) in the abdomen and pelvis.
  
  
  METHODS
  We performed a retrospective review of index CT examinations of the abdomen and pelvis in patients with melanoma and recorded all findings suggestive of metastatic disease.
  
  
  RESULTS
  Metastases were present on 36% (181/508) of the index examinations and most commonly involved the liver (47%) and pelvic lymph nodes (27%). Lower extremity primaries had the highest rate of metastasis (52%). Ocular and head and neck melanomas have a predilection to metastasize to the liver (hepatic involvement in 70% and 63%, respectively, of patients with metastatic disease) and metastases from lower extremity primaries most commonly involve pelvic lymph nodes (54% of patients with metastatic disease). Metastases to atypical locations were present in 14% of patients and most commonly occurred in the subcutaneous tissue and spleen. Primary tumors of the lower extremity, back and head and neck were most commonly associated with atypical metastases. Pelvic metastases are more common with lower extremity primaries (accounting for 70% of cases with pelvic metastases) but 5% of patients with supraumbilical primaries also had pelvic metastases.
  
  
  CONCLUSIONS
  The distribution of metastatic melanoma in the abdomen and pelvis that we have defined should help guide the interpretation of CT exams in these patients.
authors.affiliation: Andrew T Trout, Joel F Platt, Department of Radiology, University of Michigan, Ann Arbor, MI 48109, United States.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Trout
authors.forename: Risa S
authors.initials: RS
authors.lastname: Rabinowitz
authors.forename: Joel F
authors.initials: JF
authors.lastname: Platt
authors.forename: Khaled M
authors.initials: KM
authors.lastname: Elsayes
keywords: Abdomen; Computed tomography; Melanoma; Metastases; Pelvis