title: IL-1 and EGF regulate expression of genes important in inflammation and cancer.
abstract: This review focuses on the mechanisms by which the expression of specific genes is regulated by two proteins that are important in inflammation and cancer, namely the pro-inflammatory cytokine interleukin (IL)-1β and epidermal growth factor (EGF). In the review the receptors that recognize factors that cause inflammation are described with main focus on the receptors associated with activation of IL-1β. The function of IL-1β and pathways leading to activation of transcription factors, particularly NFκB and Elk-1 are analyzed. Then the mechanisms of EGF action, with particular emphasis of the activation of Elk-1 are illustrated. The link between aberrant signaling of EGF receptor family members and cancer development is explained. The relationship between inflammation and tumorigenesis is discussed.
authors.affiliation: Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland. aneta.kasza@uj.edu.pl
authors.forename: Aneta
authors.initials: A
authors.lastname: Kasza
mesh_terms: D000818:Animals; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000473:pathology; D007375:Interleukin-1 / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D018123:Receptors, Interleukin / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D018123:Receptors, Interleukin; D004815:Epidermal Growth Factor; D066246:ErbB Receptors