title: What is the next step for gastric atypical epithelium on histological findings of endoscopic forceps biopsy?
abstract: BACKGROUND
  Gastric atypical epithelium on endoscopic biopsy is borderline lesions between benign and malignant. Definitive management of this lesion remains debatable.
  
  
  OBJECTIVE
  We aimed to analyze the final histological diagnosis for atypical epithelium on endoscopic biopsy and to examine the discrepancy rate between the final histological diagnosis and the initial endoscopic assessment.
  
  
  METHODS
  This retrospective study finally enrolled 24 cases proven atypical epithelium on initial histology of an endoscopic biopsy. Of 24 cases, endoscopic submucosal dissection (n = 22), operation (n = 1) and follow-up biopsy without endoscopic submucosal dissection (n = 1) were performed.
  
  
  RESULTS
  Of the 24 cases, early gastric cancer (n = 15, 62%) and adenoma (n = 7, 30%) lesions were finally diagnosed in 22 cases. Age, sex, endoscopic results and number of biopsy did not significantly influence the result of final outcome. Between the initial endoscopic assessment and the final histological diagnosis, 12 cases (50%) showed a concordant diagnosis, but eight (33%) and four cases (17%) showed upgraded and downgraded diagnoses, respectively.
  
  
  CONCLUSIONS
  Of atypical epithelium cases, the rate of malignant and premalignant lesions was 92% and it was difficult to distinguish between malignant and benign lesions using the initial endoscopic findings. Therefore, endoscopic submucosal dissection can be considered in patients with atypical epithelium on endoscopic biopsy.
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Konkuk University Medical Center, Seoul, Republic of Korea.
authors.forename: So-I
authors.initials: SI
authors.lastname: Kim
authors.forename: Hye Seung
authors.initials: HS
authors.lastname: Han
authors.forename: Jeong Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Kyung-Ju
authors.initials: KJ
authors.lastname: Lee
authors.forename: Sung Noh
authors.initials: SN
authors.lastname: Hong
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Heung Up
authors.initials: HU
authors.lastname: Kim
authors.forename: Tae Sik
authors.initials: TS
authors.lastname: Sung
authors.forename: Heifeng
authors.initials: H
authors.lastname: Zheng
authors.forename: In-Kyung
authors.initials: IK
authors.lastname: Sung
authors.forename: Hyung Seok
authors.initials: HS
authors.lastname: Park
authors.forename: Chan Sup
authors.initials: CS
authors.lastname: Shim
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000236:Adenoma / Q000473:pathology* / Q000601:surgery; D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D004210:Dissection; D055088:Early Detection of Cancer; D004848:Epithelium / Q000473:pathology / Q000601:surgery; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology* / Q000601:surgery; D005756:Gastritis / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery