title: Catalytic enantioselective desymmetrization of meso cyclic anhydrides via iridium-catalyzed hydrogenation.
abstract: A novel method to desymmetrize meso-anhydrides into lactones via asymmetric hydrogenation catalyzed by the Ir-C3*-TunePhos complex has been developed. Various chiral lactones were synthesized with full conversion and excellent enantioselectivity under high reaction temperature.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, 430072, China.
authors.forename: Tang-Lin
authors.initials: TL
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Huiling
authors.initials: H
authors.lastname: Geng
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006358:Hot Temperature; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000812:Anhydrides; D007783:Lactones; D007495:Iridium