title: Proteasome-independent p53 degradation.
abstract: The intracellular levels of the p53 tumor suppressor protein are regulated through various pathways and involve numerous regulatory components. A recent study published in Cell Research identifies a proteasome-independent pathway of p53 protein degradation in the nucleolus that is dependent on Def and Calpain3.
authors.affiliation: Department of Biology, York University, Toronto, ON, Canada.
authors.forename: Mais M
authors.initials: MM
authors.lastname: Nuaaman
authors.forename: Samuel
authors.initials: S
authors.lastname: Benchimol
mesh_terms: D000818:Animals; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53; D029961:Zebrafish Proteins; C507219:digestive-organ expansion factor, zebrafish; D046988:Proteasome Endopeptidase Complex