title: Plasma selenium levels in Turkish women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate selenium (Se) levels in serum and their relation with hyperandrogenism and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and in control subjects.
  
  
  METHODS
  Women with any gynecological problem who presented to the Kahramanmaras Sutcuimam University Medical Faculty Gynecology and Obstetric Outpatient Clinic were invited to participate. Group 1 consisted of 36 cases with a diagnosis of PCOS according to the 2003 Rotterdam Consensus Criteria, and Group 2 (control group) consisted of 33 age- and BMI-matched healthy women. In all cases, serum total testosterone (tT), dihydroepiandrostenedione-sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), insulin, glucose (mg/dL), total cholesterol (TC) (mg/dL), high density lipoprotein-cholesterol (HDL-C) (mg/dL), low density lipoprotein-cholesterol (LDL-C) (mg/dL), triglyceride (TG) (mg/dL) and Se levels were measured.
  
  
  RESULTS
  The level of FSH was significantly lower, and the levels of LH, E2, tT, and DHEAS were significantly higher in group 1 than in group 2 (p<0.05). The hirsutism score was significantly higher among PCOS women compared to the control group (p<0.05). Although insulin levels and HOMA-IR were markedly increased in the PCOS group compared to the control group, the differences were not significant (p>0.05). The plasma Se level was significantly lower in PCOS women compared to the control group (p<0.05). When we combined the all women in two groups, regarding them as one group (combined group, n=69), a negative correlation between Se and LH and tT was present (p<0.05).
  
  
  CONCLUSIONS
  Our results show decreased plasma concentrations of Se and a negative correlation between Se and LH, tT in women with PCOS. These results indicate that Se may play a role in the pathogenesis of PCOS related with hyperandrogenism.
authors.affiliation: Kahramanmaras Sutcuimam University Medical Faculty, Department of Obstetrics and Gynecology, Kahramanmaras, Turkey. drayhancoskun@hotmail.com
authors.forename: Ayhan
authors.initials: A
authors.lastname: Coskun
authors.forename: Tugba
authors.initials: T
authors.lastname: Arikan
authors.forename: Metin
authors.initials: M
authors.lastname: Kilinc
authors.forename: Deniz Cemgil
authors.initials: DC
authors.lastname: Arikan
authors.forename: Hasan Çetin
authors.initials: HÇ
authors.lastname: Ekerbiçer
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D015536:Down-Regulation; D004958:Estradiol / Q000097:blood; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology*; D007333:Insulin Resistance; D007986:Luteinizing Hormone / Q000097:blood; D050177:Overweight / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D012643:Selenium / Q000097:blood* / Q000172:deficiency; D013739:Testosterone / Q000097:blood*; D014421:Turkey; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D043373:Follicle Stimulating Hormone, Human; D013739:Testosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D007986:Luteinizing Hormone; D012643:Selenium