title: Asymmetric synthesis of L-carbidopa based on a highly enantioselective α-amination.
abstract: A stereoselective synthesis of L-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox.
authors.affiliation: Department of Chemistry, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
authors.forename: Àlex
authors.initials: À
authors.lastname: Pericas
authors.forename: Alexandr
authors.initials: A
authors.lastname: Shafir
authors.forename: Adelina
authors.initials: A
authors.lastname: Vallribera
mesh_terms: D000586:Amination; D001391:Azo Compounds / Q000737:chemistry; D002230:Carbidopa / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001391:Azo Compounds; C572223:di-tert-butyl azodicarboxylate; D002230:Carbidopa