title: PEG hydrogel degradation and the role of the surrounding tissue environment.
abstract: Poly(ethylene glycol) (PEG)-based hydrogels are extensively used in a variety of biomedical applications, due to ease of synthesis and tissue-like properties. Recently there have been varied reports regarding PEG hydrogel's degradation kinetics and in vivo host response. In particular, these studies suggest that the surrounding tissue environment could play a critical role in defining the inflammatory response and degradation kinetics of PEG implants. In the present study we demonstrated a potential mechanism of PEG hydrogel degradation, and in addition we show potential evidence of the role of the surrounding tissue environment on producing variable inflammatory responses.
authors.affiliation: Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Branden
authors.initials: B
authors.lastname: Reid
authors.forename: Matthew
authors.initials: M
authors.lastname: Gibson
authors.forename: Anirudha
authors.initials: A
authors.lastname: Singh
authors.forename: Janis
authors.initials: J
authors.lastname: Taube
authors.forename: Cecilia
authors.initials: C
authors.lastname: Furlong
authors.forename: Melissa
authors.initials: M
authors.lastname: Murcia
authors.forename: Jennifer
authors.initials: J
authors.lastname: Elisseeff
mesh_terms: D000818:Animals; D020100:Hydrogels / Q000493:pharmacokinetics* / Q000494:pharmacology; D008422:Materials Testing; D009928:Organ Specificity / Q000187:drug effects; D011092:Polyethylene Glycols / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D020100:Hydrogels; D011092:Polyethylene Glycols; C000595209:polyethylene glycol 1000
keywords: degradation; hydrogel; inflammatory response; macrophages; neutrophils; poly(ethylene glycol); reactive oxygen species (ROS)