title: Characterization of anamnestic T-cell responses induced by conventional vaccines against contagious bovine pleuropneumonia.
abstract: A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-γ responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4(+) T lymphocytes. Moreover, CD62L expression indicated that both CD4(+) effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1-vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines.
authors.affiliation: Centre International de Recherche en Agronomie pour le Développement, UMR CMAEE, Montpellier, France. philippe.totte@cirad.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Totte
authors.forename: Aboubakar
authors.initials: A
authors.lastname: Yaya
authors.forename: Amadou
authors.initials: A
authors.lastname: Sery
authors.forename: Hezron
authors.initials: H
authors.lastname: Wesonga
authors.forename: Abel
authors.initials: A
authors.lastname: Wade
authors.forename: Jan
authors.initials: J
authors.lastname: Naessens
authors.forename: Mamadou
authors.initials: M
authors.lastname: Niang
authors.forename: François
authors.initials: F
authors.lastname: Thiaucourt
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D007156:Immunologic Memory; D011002:Pleuropneumonia, Contagious / Q000276:immunology / Q000517:prevention & control*
chemical_list: D001428:Bacterial Vaccines