title: Effect of vitamin E on alloxan-induced mouse diabetes.
abstract: OBJECTIVE
  Alloxan generates hydrogen peroxide in the body, and a small amount of alloxan administered to acatalasemic mice results in diabetes. D-α-Tocopherol (vitamin E) is an antioxidant which helps prevent excess oxidation in the body. In this study, we examined the effect of vitamin E on diabetes caused by alloxan administration in mice.
  
  
  METHODS
  Mice were maintained on a vitamin E-deprived diet and supplemented diet, respectively, for 14 weeks. Alloxan was then intraperitoneally administered, and blood glucose, glucose tolerance and the insulin level in mouse blood were examined.
  
  
  RESULTS
  Hyperglycemia was observed in the mice maintained on the vitamin E-deprived diet. The incidence of hyperglycemia in the mice maintained on the vitamin E-deprived diet was significantly higher than that in the mice maintained on the supplemented diet. The abnormal glucose metabolism caused by alloxan administration was ameliorated by the vitamin E-supplemented diet.
  
  
  CONCLUSIONS
  It is deduced that vitamin E can prevent a decrease of insulin concentration in the blood in this mouse model.
authors.affiliation: Department of Life Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan.
authors.forename: Wakana
authors.initials: W
authors.lastname: Kamimura
authors.forename: Wakana
authors.initials: W
authors.lastname: Doi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Takemoto
authors.forename: Kohji
authors.initials: K
authors.lastname: Ishihara
authors.forename: Da-Hong
authors.initials: DH
authors.lastname: Wang
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Sen-Ichi
authors.initials: S
authors.lastname: Oda
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Masuoka
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000284:Administration, Oral; D000496:Alloxan; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D002096:C-Peptide / Q000097:blood; D002374:Catalase / Q000097:blood; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D018384:Oxidative Stress; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D000496:Alloxan; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002374:Catalase; D003849:Deoxyguanosine; D024502:alpha-Tocopherol