title: Levels of metallic elements and their potential relationships to cognitive function among elderly from Federal Land Development Authority (FELDA) settlement in Selangor Malaysia.
abstract: Exposure to toxic metals and excessive amount of trace elements is a risk factor of cognitive decline. Continuous monitoring of these elements by the use of metabolically inactive tissues such as fingernails may help in taking preventive measures to delay the cognitive decline process. In this study, the cognitive function of 54 elderlies (60-72 years old) from FELDA Sungai Tengi, Selangor, was evaluated using the Malay version of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). The levels of arsenic (As), cadmium (Cd), copper (Cu), manganese (Mn), lead (Pb), and zinc (Zn) in fingernail were detected using Inductively Coupled Plasma-Mass Spectrometry. Results showed that (92.6 %) our population was cognitively impaired based on the MoCA with mean score of 18.07 ± 5.11. The mean level of elements in fingernails for As, Cd, Cu, Mn, Pb, and Zn were 16.68 ± 3.52, 4.26 ± 0.91, 4.81 ± 1.16, 1.00 ± 0.23, 1.83 ± 0.47, and 40.86 ± 10.81 μg/g, respectively. Significant inverse correlations were observed between MoCA with age (r = -0.543, p < 0.01), Cu level (r = -0.330, p < 0.05), and Mn level (r = -0.496, p < 0.01). MMSE was correlated to age (r = -0.346, p < 0.05) only. In conclusion, besides aging, the progression of cognitive decline among the elderly FELDA population was associated with increased levels of copper and manganese.
authors.affiliation: Biomedical Science Programme, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia. rohi@fskb.ukm.my
authors.forename: Ahmad Rohi
authors.initials: AR
authors.lastname: Ghazali
authors.forename: Firdaus
authors.initials: F
authors.lastname: Kamarulzaman
authors.forename: Che Din
authors.initials: CD
authors.lastname: Normah
authors.forename: Mahadir
authors.initials: M
authors.lastname: Ahmad
authors.forename: Shazli Ezzat
authors.initials: SE
authors.lastname: Ghazali
authors.forename: Norhayati
authors.initials: N
authors.lastname: Ibrahim
authors.forename: Zaini
authors.initials: Z
authors.lastname: Said
authors.forename: Suzana
authors.initials: S
authors.lastname: Shahar
authors.forename: Norhana
authors.initials: N
authors.lastname: Angkat
authors.forename: Rosdinom
authors.initials: R
authors.lastname: Razali
mesh_terms: D000368:Aged; D003071:Cognition / Q000187:drug effects*; D003430:Cross-Sectional Studies; D006801:Humans; D008296:Malaysia; D008670:Metals / Q000032:analysis / Q000633:toxicity*; D008875:Middle Aged; D009262:Nails / Q000737:chemistry*
chemical_list: D008670:Metals