title: Synthesis and characterization of theranostic poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymer targeting tumor angiogenesis: tumor localization visualized by positron emission tomography.
abstract: Poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymers were synthesized and characterized for tumor localization in vivo as a theranostic scaffold for cancer imaging and anticancer drug delivery targeting tumor angiogenesis. Tumor localization of the poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymers was visualized in mice bearing human prostate cancer xenografts by positron emission tomography (PET) using a microPET scanner. PET quantitative analysis demonstrated that tumor 64Cu radioactivity (2.75 ± 0.34 %ID/g) in tumor-bearing mice 3 hours following intravenous injection of the poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymers was significantly higher than the tumor 64Cu radioactivity (1.29 ± 0.26 %ID/g) in tumor-bearing mice injected with the nontargeted poly(HPMA)-DOTA-64Cu copolymers (p = .004). The poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymers hold potential as a theranostic scaffold for cancer imaging and radiochemotherapy of prostate cancer targeting tumor angiogenesis by noninvasive tracking with PET.
authors.affiliation: Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA.
authors.forename: Jianchao
authors.initials: J
authors.lastname: Yuan
authors.forename: Haiyuan
authors.initials: H
authors.lastname: Zhang
authors.forename: Harpreet
authors.initials: H
authors.lastname: Kaur
authors.forename: David
authors.initials: D
authors.lastname: Oupicky
authors.forename: Fangyu
authors.initials: F
authors.lastname: Peng
mesh_terms: D000818:Animals; D003301:Copper Radioisotopes / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000737:chemistry*; D051379:Mice; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis*
chemical_list: D003301:Copper Radioisotopes; D006573:Heterocyclic Compounds, 1-Ring; D008689:Methacrylates; D011108:Polymers; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; C032802:hydroxypropyl methacrylate