title: A new strategy for efficient synthesis of medium and large ring lactones without high dilution or slow addition.
abstract: We have developed an efficient method for medium and large ring lactone synthesis by a conceptually different ring-expansion strategy. The design of an unprecedented ring conjunction mode of oxetene, combined with the appropriate choice of a Lewis acid promoter and an additive, constitutes the key components of the new process. Enabled by this new approach, the reaction does not require high dilution or slow addition.
authors.affiliation: Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
authors.forename: Wanxiang
authors.initials: W
authors.lastname: Zhao
authors.forename: Zigang
authors.initials: Z
authors.lastname: Li
authors.forename: Jianwei
authors.initials: J
authors.lastname: Sun
mesh_terms: D003500:Cyclization; D003503:Cyclobutanes / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry
chemical_list: D003503:Cyclobutanes; D007783:Lactones; D058116:Lewis Acids