title: Targeting cellular apoptotic pathway with peptides from marine organisms.
abstract: Apoptosis is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. Targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Peptides from marine organisms have become important sources in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. This primer summarizes several marine peptides, based on their effects on apoptotic signaling pathways, although most of these peptides have not yet been studied in depth for their mechanisms of action. Novel peptides that induce an apoptosis signal pathway are presented in association with their pharmacological properties.
authors.affiliation: Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China.
authors.forename: Lanhong
authors.initials: L
authors.lastname: Zheng
authors.forename: Xiukun
authors.initials: X
authors.lastname: Lin
authors.forename: Ning
authors.initials: N
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jun
authors.initials: J
authors.lastname: Sheng
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Ji
authors.forename: Mi
authors.initials: M
authors.lastname: Sun
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D059001:Aquatic Organisms / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010446:Peptide Fragments / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010446:Peptide Fragments