title: Oxygen tension in rat brain during hyperoxia [corrected].
abstract: Critical value of oxygen tension (Po2) and cerebral blood flow in the striatum for seizure appearance during hyperbaric oxygenation (5 ATA) were determined in awake Wistar rats. Seizure activity was observed at Po2=1030±102 mm Hg. A relationship between brain Po2 and blood flow was revealed at different regimens of hyperbaric oxygenation using a mathematical model. Comparison of experimental data and mathematical model showed that seizure-inducing levels of Po2during hyperbaric oxygenation at 4, 5, and 6 ATA can be achieved after increasing blood flow by 1.5-3.0, 1.2-2.0, and 0.8-1.1, respectively.
authors.affiliation: Laboratory for Hyperbaric Physiology, I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences, Sankt-Petersburg, Russia. moskvin_an@mail.ru
authors.forename: A N
authors.initials: AN
authors.lastname: Moskvin
authors.forename: Yu I
authors.initials: YI
authors.lastname: Luchakov
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology; D006439:Hemodynamics; D006931:Hyperbaric Oxygenation; D008297:Male; D008962:Models, Theoretical; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology