title: GATA-3 locks the door to the B-cell option.
abstract: In this issue of Blood, García-Ojeda et al demonstrate a key mechanism that drives T and B lymphocytes to divergent fates from early in their development.
authors.affiliation: California Institute of Technology, CA, USA.
authors.forename: Ellen V
authors.initials: EV
authors.lastname: Rothenberg
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology*; D005260:Female; D050990:GATA3 Transcription Factor / Q000502:physiology*; D008297:Male; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology*
chemical_list: D050990:GATA3 Transcription Factor; C494748:Gata3 protein, mouse