title: Sesquineolignans and terpene-sesquineolignans: anti-acetylcholinesterase constituents from Illicium simonsii.
abstract: Chemical investigation of the aerial parts of Illicium simonsii resulted in the isolation of nine new compounds, simonsols A-E (1-5), simonsins A-B (7-8), terpene-sesquineolignans, clovanedunnianol (9), and p-menthadunnianol (10). Compound 5 was equilibrated with 7 as an inseparable mixture. The structures were elucidated by extensive NMR and MS analysis. Compounds 9, 10, and the mixture of 5 and 7 moderately inhibited acetylcholinesterase with IC50 values of 4.58 µM, 6.55 µM, and 10.34 µM, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
authors.forename: Chuanfu
authors.initials: C
authors.lastname: Dong
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Xiaonian
authors.initials: X
authors.lastname: Li
authors.forename: Zhengye
authors.initials: Z
authors.lastname: Guan
authors.forename: Huairong
authors.initials: H
authors.lastname: Luo
authors.forename: Yifen
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D029523:Illicium / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001572:Benzofurans; D002800:Cholinesterase Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D006576:Heterocyclic Compounds, 4 or More Rings