title: Multifunctional nanoparticles based on a single-molecule modification for the treatment of drug-resistant cancer.
abstract: Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy. Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been extensively explored for the treatment of MDR in cancer because of its ability to inhibit P-glycoprotein. Here, we have established multifunctional nanoparticles (MFNPs) using a single-molecule modification of TPGS, which can deliver a hydrophobic drug, paclitaxel (PTX), and a hydrophilic drug, fluorouracil (5-FU), and overcome MDR in cancer. Our data indicated that, when delivered into a PTX-resistant cell line using MFNPs, the combination of PTX and 5-FU was more cytotoxic than each agent individually.
authors.affiliation: Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Dun
authors.initials: D
authors.lastname: Wang
authors.forename: Jingling
authors.initials: J
authors.lastname: Tang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
authors.forename: Srinivas
authors.initials: S
authors.lastname: Ramishetti
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.forename: Kelly
authors.initials: K
authors.lastname: Racette
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000737:chemistry; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015195:Drug Design; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005434:Flow Cytometry; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology; D020112:Rhodamine 123 / Q000494:pharmacology; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D014810:Vitamin E; D020112:Rhodamine 123; D011092:Polyethylene Glycols; C014225:tocophersolan; D017239:Paclitaxel; D005472:Fluorouracil