title: Lacosamide-induced valproic acid toxicity.
abstract: Valproic acid is commonly used in the treatment of both focal and generalized epilepsies and is often well tolerated. There are many reported cases of hyperammonemic encephalopathy and other well-known side effects reported during use of valproic acid either alone or in combination with other antiepileptics. This case report demonstrates valproic acid toxicity in the presence of lacosamide, which has not previously been reported. Full recovery occurred after withdrawal of both valproic acid and lacosamide.
authors.affiliation: Department of Neurology, Section of Pediatric Neurology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, USA. gljones2@cmh.edu
authors.forename: Gina L
authors.initials: GL
authors.lastname: Jones
authors.forename: Gautam S
authors.initials: GS
authors.lastname: Popli
authors.forename: Mary T
authors.initials: MT
authors.lastname: Silvia
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000009:adverse effects*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D022124:Hyperammonemia / Q000139:chemically induced* / Q000175:diagnosis*; D000078334:Lacosamide; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide; D014635:Valproic Acid