title: Viruses and prions of Saccharomyces cerevisiae.
abstract: Saccharomyces cerevisiae has been a key experimental organism for the study of infectious diseases, including dsRNA viruses, ssRNA viruses, and prions. Studies of the mechanisms of virus and prion replication, virus structure, and structure of the amyloid filaments that are the basis of yeast prions have been at the forefront of such studies in these classes of infectious entities. Yeast has been particularly useful in defining the interactions of the infectious elements with cellular components: chromosomally encoded proteins necessary for blocking the propagation of the viruses and prions, and proteins involved in the expression of viral components. Here, we emphasize the L-A dsRNA virus and its killer-toxin-encoding satellites, the 20S and 23S ssRNA naked viruses, and the several infectious proteins (prions) of yeast.
authors.affiliation: Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. wickner@helix.nih.gov
authors.forename: Reed B
authors.initials: RB
authors.lastname: Wickner
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fujimura
authors.forename: Rosa
authors.initials: R
authors.lastname: Esteban
mesh_terms: D011328:Prions / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D012328:RNA Viruses / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology / Q000648:ultrastructure; D019244:RNA, Satellite / Q000235:genetics / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000821:virology*
chemical_list: D011328:Prions; D019244:RNA, Satellite