title: Impaired coronary microvascular function and its association with disease duration and inflammation in patients with psoriasis.
abstract: METHODS
  Thirty-six patients with psoriasis and 56 healthy volunteers were included in this study.
  
  
  METHODS
  Echocardiographic examination included transmitral peak flow velocities of the early phase (E) and late phase (A) of the mitral inflow, left ventricular myocardial velocity measurements, and coronary flow reserve (CFR) measurement.
  
  
  RESULTS
  Baseline coronary diastolic peak flow velocity (DPFV) of left anterior descending artery (LAD) was significantly higher in the psoriasis group. However, hyperemic DPFV was slightly lower and CFR (2.19 ± 0.39 vs. 2.60 ± 0.31, P < 0.0001) was significantly lower in the psoriasis group than in the control group. CFR was significantly and inversely correlated with disease duration, Psoriasis Area and Severity Index (PASI) score, and hsCRP.
  
  
  CONCLUSIONS
  CFR is decreased in patients with psoriasis, and it correlates to disease duration, PASI score, and inflammation.
authors.affiliation: Cardiology Department, Adana Teaching and Medical Research Center, Baskent University, Adana, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Gullu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Caliskan
authors.forename: Recep
authors.initials: R
authors.lastname: Dursun
authors.forename: Ozgur
authors.initials: O
authors.lastname: Ciftci
authors.forename: Aytekin
authors.initials: A
authors.lastname: Guven
authors.forename: Haldun
authors.initials: H
authors.lastname: Muderrisoglu
mesh_terms: D000328:Adult; D015984:Causality; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D055806:Microvessels / Q000000981:diagnostic imaging; D015995:Prevalence; D011565:Psoriasis / Q000175:diagnosis* / Q000453:epidemiology*; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013223:Statistics as Topic; D014421:Turkey / Q000453:epidemiology; D014463:Ultrasonography
keywords: coronary flow reserve; echocardiography; psoriasis