title: The contribution of the C-824T tyrosine hydroxylase polymorphism to the prevalence of hypertension in a South African cohort: the SABPA study.
abstract: The C-824T single nucleotide polymorphism in the promoter region of the tyrosine hydroxylase gene has been associated with hypertension. It is well documented that African South Africans exhibit a higher prevalence of hypertension than Caucasians. However, the possible role of this mutation on 24-hour ambulatory blood pressure (AMBP) has not been investigated in African South Africans. Blood samples of 409 South Africans were screened for the mutation. Ambulatory blood pressure and lifestyle factors were also measured. Africans had higher incidence of hypertension and higher occurrence of the mutation. However, the contribution of the tyrosine hydroxylase C-824T single nucleotide polymorphism to hypertension could not be confirmed in our cohort.
authors.affiliation: Centre for Human Metabonomics, North-West University (Potchefstroom Campus) , Potchefstroom , South Africa.
authors.forename: Cindy A
authors.initials: CA
authors.lastname: van Deventer
authors.forename: Roan
authors.initials: R
authors.lastname: Louw
authors.forename: Francois H
authors.initials: FH
authors.lastname: van der Westhuizen
authors.forename: Chris B
authors.initials: CB
authors.lastname: Vorster
authors.forename: Leoné
authors.initials: L
authors.lastname: Malan
mesh_terms: D000328:Adult; D044383:Black People / Q000235:genetics* / Q000706:statistics & numerical data; D001794:Blood Pressure / Q000235:genetics*; D018660:Blood Pressure Monitoring, Ambulatory; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D013019:South Africa / Q000453:epidemiology; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*; D044465:White People / Q000235:genetics* / Q000706:statistics & numerical data
chemical_list: D014446:Tyrosine 3-Monooxygenase