title: Genotypic and phenotypic analysis of in vivo tissue regeneration in an animal model.
abstract: Determining the in vivo response to cellular therapies is important in evaluating the effectiveness of regenerative medicine therapies. Such treatment modalities leverage the treated individual's ability to elicit the body's innate healing response to repair/regenerate damaged tissues or organs. Detailed within this chapter is the process of evaluating the host tissue response to a candidate cell therapy through analysis of key transcript and protein targets.
authors.affiliation: Tengion Inc., Winston-Salem, NC, USA.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Genheimer
mesh_terms: D000818:Animals; D015153:Blotting, Western; D007668:Kidney / Q000502:physiology*; D060888:Real-Time Polymerase Chain Reaction; D012038:Regeneration / Q000502:physiology*; D044968:Regenerative Medicine / Q000379:methods*; D051436:Renal Insufficiency, Chronic / Q000628:therapy*; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*