title: Study of macrophages in BCG granulomas in different compartments of the mononuclear phagocyte system.
abstract: We studied in vitro morphological and functional properties of macrophages associated with their M1 and M2 polarization in different mononuclear phagocyte compartments during BCG-induced granuloma formation, namely expression patterns of cytokines IL-1α, GM-CSF, TNF-α, and clusters of differentiation CD36 and CD16/32. We showed the mosaic pattern of macrophage polarization in BCG granulomatosis manifested by simultaneous formation of different macrophage subpopulations with M1 and M2 phenotypes in the population of mononuclear phagocytes of BCG granulomas and various compartments of the mononuclear phagocyte system. These data clarify the role of the functional polarization of macrophages in the pathogenesis of tuberculosis infection.
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. arkhipov@soramn.ru
authors.forename: S A
authors.initials: SA
authors.lastname: Arkhipov
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupy
authors.forename: M V
authors.initials: MV
authors.lastname: Solomatina
authors.forename: E S
authors.initials: ES
authors.lastname: Akhramenko
authors.forename: D A
authors.initials: DA
authors.lastname: Iljine
mesh_terms: D000818:Animals; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism; D006099:Granuloma / Q000378:metabolism*; D053582:Interleukin-1alpha / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012157:Mononuclear Phagocyte System / Q000166:cytology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D053582:Interleukin-1alpha; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor