title: Biomolecular magic-angle spinning solid-state NMR: recent methods and applications.
abstract: The link of structure and dynamics of biomolecules and their complexes to their function and to many cellular processes has driven the quest for their detailed characterization by a variety of biophysical techniques. Magic-angle spinning solid-state nuclear magnetic resonance spectroscopy provides detailed information on the structural properties of such systems and in particular contributes invaluable information on non-soluble, large molecular-weight and non-crystalline biomolecules. This review summarizes the recent progress that has been made in the characterization of macromolecular assemblies, viruses, membrane proteins, amyloid fibrils, protein aggregates and more by magic-angle spinning solid-state NMR.
authors.affiliation: School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel. amirgo@post.tau.ac.il
authors.forename: Amir
authors.initials: A
authors.lastname: Goldbourt
mesh_terms: D000682:Amyloid / Q000737:chemistry; D000818:Animals; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D014780:Viruses / Q000737:chemistry*
chemical_list: D000682:Amyloid; D011506:Proteins