title: [Expression of RAGE-1 gene in acute myeloid leukemia].
abstract: The purpose of this study was to detect the expression of RAGE-1 transcript in the bone marrow mononuclear cells (BMMNC) from patients with acute myeloid leukemia (AML) and to investigate the relationship of RAGE-1 expression level with clinical variables. The expression level of RAGE-1 gene in BMMNC from 94 newly diagnosed AML patients was measured using RQ-PCR. The relationship between RAGE-1 expression level and clinical parameters (age, sex, blood cell counts, diagnosis and prognosis) was investigated, and the levels of RAGE-1 expression were compared in patients before and after treatment. The results showed that overexpression of RAGE-1 transcript was found in 28% (26/94) AML patients (1.34 - 16.34, median 3.07). No significant difference was observed in sex, age, blood parameters and FAB subtypes between the groups with and without RAGE-1 overexpression. There was also no significant difference in the frequency of RAGE-1 overexpression among different cytogenetic risk groups and among the patients with different types of karyotypes. The level of RAGE-1 transcript significantly decreased in those patients obtained complete remission after treatment. The overall survival of AML patients with RAGE-1 overexpression was similar as that in those without RAGE-1 overexpression. It is concluded that RAGE-1 overexpression is a common event in AML, but has no impact on the prognosis of patients.
authors.affiliation: Shanxi Medical University First Clinical Hospital, Taiyuan, Shanxi Province, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Chai
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.forename: Jiang
authors.initials: J
authors.lastname: Lin
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.forename: Cui-Zhu
authors.initials: CZ
authors.lastname: Wang
authors.forename: Xing-Xing
authors.initials: XX
authors.lastname: Chen
authors.forename: Qin
authors.initials: Q
authors.lastname: Chen
authors.forename: Zhao-Qun
authors.initials: ZQ
authors.lastname: Deng
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Yao
authors.forename: Ji-Chun
authors.initials: JC
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D045744:Cell Line, Tumor; D005260:Female; D015870:Gene Expression; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult; D000951:Antigens, Neoplasm; D020928:Mitogen-Activated Protein Kinases
chemical_list: D000951:Antigens, Neoplasm; C498978:MOK protein, human; D020928:Mitogen-Activated Protein Kinases