title: Obesity, diabetes mellitus, and the risk of female breast cancer in Eastern China.
abstract: BACKGROUND
  This study was designed to explore the relationship between obesity, diabetes mellitus (DM), and female breast cancer in Eastern China.
  
  
  METHODS
  A 1:3 matched case-control study was carried out, comprising 123 women with breast cancer and 369 controls. All of the 492 subjects were selected from a previous epidemiological survey of 122,058 women in Eastern China.
  
  
  RESULTS
  There were significant differences between the case and control groups in waist circumference and body mass index (BMI), but not in waist to hip ratio or hip circumference. There was a significant difference between the two groups in BMI for post-menopausal women, and a significant difference in waist circumference for pre-menopausal women. After adjustment for other factors, BMI was still significantly associated with breast cancer (odds ratio (OR) = 1.58, 95% confidence interval (CI) 1.14 to 2.19). DM was significantly associated with breast cancer (OR = 3.35, 95% CI 1.02 to 11.01) in the univariate analysis but not in the multivariate analysis (P = 0.059).
  
  
  CONCLUSIONS
  Obesity might be a risk factor for female breast cancer. We found different strengths of association for women with different menopausal status when we examined the relationship between obesity and breast cancer. The association between DM and female breast cancer should be further confirmed with larger sample sizes.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 Wenhuaxi Road, Lixia district, Jinan, Shandong, 250012, China.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Wang
authors.forename: Cun-Xian
authors.initials: CX
authors.lastname: Jia
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yu-Yang
authors.initials: YY
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000209:etiology*; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications* / Q000175:diagnosis; D016017:Odds Ratio; D017698:Postmenopause; D017697:Premenopause; D016016:Proportional Hazards Models; D012307:Risk Factors; D055105:Waist Circumference; D049629:Waist-Hip Ratio