title: Synthetic genomics and the construction of a synthetic bacterial cell.
abstract: The first synthetic cellular organism was created in 2010 and based on a very small, very simple bacterium called Mycoplasma mycoides. The bacterium was called synthetic because its DNA genome was chemically synthesized rather than replicated from an existing template DNA, as occurs in all other known cellular life on Earth. The experiment was undertaken in order to develop a system that would allow creation of a minimal bacterial cell that could lead to a better understand of the first principles of cellular life. The effort resulted in new synthetic genomics techniques called genome assembly and genome transplantation. The ability of scientists to design and build bacteria opens new possibilities for creating microbes to solve human problems.
authors.affiliation: J. CraigVenter Institute, 9704 Medical Center Drive, Rockville, MD 20874, USA. jglass@jcvi.org
authors.forename: John I
authors.initials: JI
authors.lastname: Glass
mesh_terms: D000818:Animals; D035843:Biomedical Research; D004269:DNA, Bacterial / Q000138:chemical synthesis*; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D005838:Genotype; D006801:Humans; D008954:Models, Biological; D008967:Molecular Biology; D009176:Mycoplasma mycoides / Q000235:genetics*; D010641:Phenotype; D058615:Synthetic Biology; D049490:Systems Biology
chemical_list: D004269:DNA, Bacterial