title: [Impact of cutaneous toxicities associated with targeted therapies on quality of life. Results of a longitudinal exploratory study].
abstract: Targeted therapies represent a promising option in cancer treatment, which have shown tumor control and patients survival benefits. But these drugs have systemic side effects, in particular frequent and various cutaneous effects. Few data have been published about the impact of these symptoms on patients' quality of life, particularly for psychological and social aspects. That is why we wished to evaluate this impact in order to propose a preventive management and optimize patients' care. Twenty-seven patients participated in both evaluation times of a longitudinal quantitative pilot study. They completed the same set of psychological questionnaires before taking treatment and 30 days after. Patients were mainly men with a metastatic lung, digestive or cutaneous cancer. Analyses showed that dermatological symptoms in 22 patients were associated for a majority of them with a decrease of quality of life, characterized by difficulties in houseworks and leisure activities, and a social functioning impairment. Adverse skin events did not seem to affect emotional state. These results must be confirmed by further investigations in a larger-scale prospective research.
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, institut de psychologie, laboratoire de psychopathologie et processus de santé - EA 4057 - IUPDP, 71, avenue Édouard-Vaillant, 92100 Boulogne, France. cecile.charles@igr.fr
authors.forename: Cécile
authors.initials: C
authors.lastname: Charles
authors.forename: Serge
authors.initials: S
authors.lastname: Sultan
authors.forename: Catherine
authors.initials: C
authors.lastname: Bungener
authors.forename: Christina
authors.initials: C
authors.lastname: Mateus
authors.forename: Emilie
authors.initials: E
authors.lastname: Lanoy
authors.forename: Sarah
authors.initials: S
authors.lastname: Dauchy
authors.forename: Michèle
authors.initials: M
authors.lastname: Verschoore
authors.forename: Caroline
authors.initials: C
authors.lastname: Robert
mesh_terms: D000203:Activities of Daily Living; D004067:Digestive System Neoplasms / Q000188:drug therapy / Q000523:psychology; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology / Q000523:psychology; D005260:Female; D006801:Humans; D007899:Leisure Activities; D008175:Lung Neoplasms / Q000188:drug therapy / Q000523:psychology; D008297:Male; D008875:Middle Aged; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D009369:Neoplasms / Q000188:drug therapy* / Q000523:psychology; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000523:psychology; D011795:Surveys and Questionnaires; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000523:psychology; D013997:Time Factors
keywords: cancer; quality of life; skin toxicities; targeted therapies