title: Synthetic and structure-activity relationship studies on bioactive natural products.
abstract: This review summarizes our research into the synthesis and structure-activity relationships of epolactaene, neoechinulin A, plakevulin A, pseudodeflectusin and ustusorane C. These natural products are attractive in view of their apoptosis-inducing activity, cytoprotective activity against peroxynitrite, inhibitory activity against DNA polymerases, and cytotoxicity in cancer cells.
authors.affiliation: Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Japan. kuramoch@kpu.ac.jp
authors.forename: Kouji
authors.initials: K
authors.lastname: Kuramochi
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D001688:Biological Products; D009930:Organic Chemicals