title: Novel powdered anti-adhesion material: preventing postoperative intra-abdominal adhesions in a rat model.
abstract: BACKGROUND
  Although laparoscopic surgery has decreased postoperative adhesions, complications induced by adhesions are still of great concern. The aim of this study was to investigate the anti-adhesive effects of a novel powdered anti-adhesion material that can be applied during laparoscopic surgery in comparison with other anti-adhesion materials.
  
  
  METHODS
  Our novel powdered anti-adhesion material is composed of aldehyde dextran and ε-poly(L-lysine). In 40 male rats, a 2.5×2.0-cm abdominal wall resection and cecum abrasion were performed. The rats were randomized into four groups based on the anti-adhesion treatments: normal saline; Seprafilm(®); Interceed(®); and novel powdered anti-adhesion material. The animals were euthanized on days 7 and 28 to evaluate the adhesion severity, area of adhesion formation, gross appearance, and pathological changes.
  
  
  RESULTS
  The adhesion severities on both days 7 and 28 were significantly lower for all anti-adhesion material groups compared with the normal saline group (p<0.05). Pathologically, all groups showed inflammatory cell infiltration on day 7 and complete regeneration of the peritoneum on day 28.
  
  
  CONCLUSIONS
  Our novel powdered anti-adhesion material was found to be effective for reducing postoperative intra-abdominal adhesions and showed equivalent efficacy to commercial anti-adhesion materials.
authors.affiliation: Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. spzq9r39@woody.ocn.ne.jp
authors.forename: Katsunori
authors.initials: K
authors.lastname: Takagi
authors.forename: Masato
authors.initials: M
authors.lastname: Araki
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Fukuoka
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeshita
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Hidaka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nanashima
authors.forename: Terumitsu
authors.initials: T
authors.lastname: Sawai
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagayasu
authors.forename: Suong-Hyu
authors.initials: SH
authors.lastname: Hyon
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakajima
mesh_terms: D000005:Abdomen / Q000473:pathology / Q000601:surgery; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002432:Cecum / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D010537:Peritoneum / Q000473:pathology / Q000601:surgery; D011182:Postoperative Care; D011208:Powders / Q000627:therapeutic use*; D051381:Rats; D000267:Tissue Adhesions / Q000473:pathology / Q000628:therapy*
chemical_list: D001672:Biocompatible Materials; D011208:Powders
keywords: adhesion prevention; anti-adhesion materials; biodegradable material; powder; rat model.