title: The effect of teucrium polium honey on the wound healing and tensile strength in rat.
abstract: OBJECTIVE
  Wound healing represents a dynamic physiological process influenced by many factors. The aim of the present study was to evaluate the effects of Teucrium polium honey on the wound healing and tensile strength in rat.
  
  
  METHODS
  Thirty-six Sprague-Dawley rats were randomly divided into four equal (n= 9) treatment and control groups. Two full-thickness wounds were made over the dorsal thoracic region according to the incision and excision models. Animals were treated with topical Teucrium polium honey twice a day post surgery until complete healing was achieved. Histopathology and tensiometry were then studied.
  
  
  RESULTS
  The wound healing process occurred faster in the incision model than excision ones (P< 0.05). Teucrium polium honey promoted wound contraction, closure time and tensile strength (P< 0.05). Histopathological study also showed relative epithelial proliferation, improved angiogenesis granulation, and fibrous connective tissue in Teucrium polium honey treated animals.
  
  
  CONCLUSIONS
  The present study demonstrates that Teucrium polium honey can accelerate wound healing as well as tensile strength in rat skin wounds.
authors.affiliation: Cancer Research Centre of Institute Cancer, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali Mohammad
authors.initials: AM
authors.lastname: Alizadeh
authors.forename: Hamid
authors.initials: H
authors.lastname: Sohanaki
authors.forename: Mahmod
authors.initials: M
authors.lastname: Khaniki
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Mohaghgheghi
authors.forename: Giti
authors.initials: G
authors.lastname: Ghmami
authors.forename: Maryamsadat
authors.initials: M
authors.lastname: Mosavi
keywords: Honey; Rat; Teucrium polium; Wound excision; Wound incision