title: Successful treatment of Kasabach-Merritt syndrome with transarterial embolization and corticosteroids.
abstract: Kasabach-Merritt syndrome (KMS) refers to the combination of large neonatal vascular tumors and thrombocytopenic coagulopathy. However, a standard treatment regimen for KMS has not yet been established. We report a case of a 6-week-old male infant with life-threatening KMS who was successfully treated with transarterial embolization and corticosteroids. One week after initiating the corticosteroid treatment, his platelet counts recovered, and the lesion growth halted. The approach with corticosteroid therapy resulted in an excellent response that was maintained long enough for us to perform transarterial embolization therapy. The combination of transarterial embolization and corticosteroid therapy should be considered as an option for Kasabach-Merritt syndrome.
authors.affiliation: Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou 510623, PR China.
authors.forename: Shao-yi
authors.initials: SY
authors.lastname: Zhou
authors.forename: Hai-bo
authors.initials: HB
authors.lastname: Li
authors.forename: Yue-ming
authors.initials: YM
authors.lastname: Mao
authors.forename: Pei-ying
authors.initials: PY
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D059885:Kasabach-Merritt Syndrome / Q000628:therapy*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D012074:Remission Induction
chemical_list: D005938:Glucocorticoids; D011241:Prednisone