title: Effect of renal graft on longitudinal growth in prepubertal children.
abstract: OBJECTIVE
  Linear growth impairment frequently accompanies chronic kidney disease in children. Despite successful renal transplant, growth retardation may persist in renal allograft recipients.
  
  
  METHODS
  We recorded the longitudinal growth and biochemical data of prepubertal children during the first 2 years after renal transplant in 34 children (18 boys [52.9%]; mean age at renal transplant, 7.3 ± 2.5 y; range, 1.4 to 9.8 y). Height standard deviation scores were calculated. The patients were divided into 2 groups according to the increase in height standard deviation scores over the first 2 years after renal transplant: group 1 (increases in height standard deviation scores < 1) and group 2 (increases in height standard deviation scores > 1).
  
  
  RESULTS
  Increases in height standard deviation scores were 0.12 ± 0.34 and 1.62 ± 0.52 for group 1 and group 2 (P < .001). The number of acute rejection episodes was significantly different between groups (P = .04). At renal transplant, increases in height standard deviation scores were negatively correlated with mean age (r: -0.354; P = .04) and height standard deviation scores (r: -0.353; P = .04). In the multivariate model, mean age and height standard deviation scores at renal transplant remained significantly associated with increases in height standard deviation scores (P = .018; β coefficient: -0.341, 95% CI: -0.17; -0.002; and P = .005; β coefficient: -0.431, 95% CI: -0.519; -0.101).
  
  
  CONCLUSIONS
  Renal transplant improves linear growth by providing moderate or accelerated growth in prepubertal children.
authors.affiliation: Department of Pediatric Nephrology, Akdeniz University, Antalya, Turkey. d.caglaserpil@yahoo.com
authors.forename: Cagla Serpil
authors.initials: CS
authors.lastname: Dogan
authors.forename: Erdem
authors.initials: E
authors.lastname: Durmaz
authors.forename: Elif
authors.initials: E
authors.lastname: Comak
authors.forename: Arife
authors.initials: A
authors.lastname: Uslu Gokceoglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Koyun
authors.forename: Sema
authors.initials: S
authors.lastname: Akman
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D001827:Body Height; D016009:Chi-Square Distribution; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection / Q000209:etiology; D006130:Growth Disorders / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome