title: Time course of the cytokine profiles during the early period of normal pregnancy and in patients with a history of habitual miscarriage.
abstract: The time course of the peripheral blood cytokine profiles was studied in patients with a history of habitual miscarriages and in normal gestation. Low levels of anti-inflammatory cytokines during the early periods of gestation were characteristic of patients with a history of habitual miscarriages; however, an anti-inflammatory shift of the cytokine spectrum developed by the end of the first trimester.
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health and Social Development, Moscow, Russia. mmz@mail.ru
authors.forename: M M
authors.initials: MM
authors.lastname: Ziganshina
authors.forename: L V
authors.initials: LV
authors.lastname: Krechetova
authors.forename: L V
authors.initials: LV
authors.lastname: Vanko
authors.forename: M A
authors.initials: MA
authors.lastname: Nikolaeva
authors.forename: Z S
authors.initials: ZS
authors.lastname: Khodzhaeva
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D011247:Pregnancy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D018664:Interleukin-12; D015847:Interleukin-4; D007371:Interferon-gamma