title: In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe.
abstract: To image implant-surrounding activated macrophages, a macrophage-specific PET probe was prepared by conjugating folic acid (FA) and 2,2',2″,2‴-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetracetic acid (DOTA) to polyethylene glycol (PEG) and then labeling the conjugate with Ga-68. In vivo PET imaging evaluations demonstrate that the probe is able to detect foreign body reactions, and more importantly, quantify the degree of inflammatory responses to an implanted medical device. These results were further validated by histological analysis.
authors.affiliation: Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Guiyang
authors.initials: G
authors.lastname: Hao
authors.forename: Hong
authors.initials: H
authors.lastname: Weng
authors.forename: Yi-Ting
authors.initials: YT
authors.lastname: Tsai
authors.forename: David W
authors.initials: DW
authors.lastname: Baker
authors.forename: Xiankai
authors.initials: X
authors.lastname: Sun
authors.forename: Liping
authors.initials: L
authors.lastname: Tang
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005492:Folic Acid / Q000737:chemistry; D005708:Gallium / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D007249:Inflammation; D008264:Macrophages / Q000166:cytology*; D051379:Mice; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D049268:Positron-Emission Tomography; D051598:Whole Body Imaging
chemical_list: D006573:Heterocyclic Compounds, 1-Ring; D009942:Organometallic Compounds; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D011092:Polyethylene Glycols; D005492:Folic Acid; D005708:Gallium