title: Drug testing in mouse models of tuberculosis and nontuberculous mycobacterial infections.
abstract: Mice as a species are susceptible to tuberculosis infection while mouse inbred strains present wide spectrum of susceptibility/resistance to this infection. However, non-tuberculosis Mycobacterial infections usually cannot be modeled in mice of common inbred strains. Introduction of specific properties, such as gene mutations, recombinants, targeted gene knockouts significantly extended the use of mice to mimic human Mycobacterial infections, including non-tuberculosis ones. This review describes the available mouse models of tuberculosis and non-tuberculosis infections and drug therapy in these models. Mouse models of non-tuberculosis infections are significantly less developed than tuberculosis models, hampering the development of therapies.
authors.affiliation: Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20852, USA. borisnikonenko@sequella.com
authors.forename: Boris V
authors.initials: BV
authors.lastname: Nikonenko
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Apt
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests / Q000379:methods; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy* / Q000235:genetics; D014376:Tuberculosis / Q000188:drug therapy* / Q000235:genetics
chemical_list: D000995:Antitubercular Agents