title: [Efficacy of ceruloplasmin in patients with asthma].
abstract: OBJECTIVE
  To evaluate the efficacy ceruloplasmin (Cp) used in the combination therapy of patients with an asthma exacerbation.
  
  
  METHODS
  The trial included 37 asthmatic patients. Chemiluminescence (ChL) registration was used to study the production of reactive oxygen species (ROS) in the patients' blood. Nineteen patients with asthma received conventional treatment. Cp was used as part of combination therapy in 18 asthmatic patients.
  
  
  RESULTS
  ChL intensity was increased the blood of patients with an asthma exacerbation. Cp treatment resulted in a reduction in the generation of ROS in the blood and contributed to positive changes in the clinical symptoms of asthma. In the patients receiving conventional therapy, the high ChL intensity of blood was retained and the clinical symptoms of the disease reduced.
  
  
  CONCLUSIONS
  The use of Cp in patients with an asthma exacerbation corrects free radical oxidation processes and enhances therapeutic effectiveness.
authors.forename: U R
authors.initials: UR
authors.lastname: Farkhutdinov
authors.forename: Sh U
authors.initials: ShU
authors.lastname: Farkhutdinov
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001682:Biological Availability; D002570:Ceruloplasmin / Q000008:administration & dosage / Q000493:pharmacokinetics; D018450:Disease Progression; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017382:Reactive Oxygen Species / Q000097:blood*; D012129:Respiratory Function Tests / Q000379:methods; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents; D017382:Reactive Oxygen Species; D002570:Ceruloplasmin