title: Narrow band imaging with magnification can pick up esophageal squamous cell carcinoma more efficiently than lugol chromoendoscopy in patients after chemoradiotherapy.
abstract: Aim. Little is known about the usefulness of narrow band imaging (NBI) for surveillance of patients after chemoradiotherapy for esophageal neoplasia. Its usefulness in detecting esophageal squamous cell carcinoma (SCC) or high-grade intraepithelial neoplasia (HGIN) in these patients was retrospectively compared to Lugol chromoendoscopy. Patients and Methods. We assessed the diagnostic ability of NBI with magnification based on the biopsy specimens obtained from iodine-unstained lesions. Seventy-two iodine-unstained lesions were biopsied and consecutively enrolled for this study. The lesions were divided into NBI positive and NBI negative. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of NBI with magnification and PPV of Lugol chromoendoscopy was calculated using histological assessment as a gold standard. Results. Forty-six endoscopic examinations using NBI with magnification followed by Lugol chromoendoscopy were performed to 28 patients. The prevalence of SCC and HGIN was 21.4%. Sensitivity, specificity, PPV, NPV, and accuracy of NBI were 100.0%, 98.5%, 85.7%, 100%, and 98.6%, respectively. On the contrary, PPV of Lugol chromoendoscopy were 8.3%. Compared to Lugol chromoendoscopy, NBI with magnification showed equal sensitivity and significantly higher PPV (P < 0.0001). Conclusion. NBI with magnification would be able to pick up esophageal neoplasia more efficiently than Lugol chromoendoscopy in patients after chemoradiotherapy.
authors.affiliation: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Itsuko
authors.initials: I
authors.lastname: Asada-Hirayama
authors.forename: Shinya
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authors.lastname: Kodashima
authors.forename: Mitsuhiro
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authors.lastname: Fujishiro
authors.forename: Satoshi
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authors.lastname: Ono
authors.forename: Keiko
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authors.lastname: Niimi
authors.forename: Satoshi
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authors.lastname: Mochizuki
authors.forename: Maki
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authors.lastname: Konno-Shimizu
authors.forename: Rie
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authors.lastname: Mikami-Matsuda
authors.forename: Chihiro
authors.initials: C
authors.lastname: Minatsuki
authors.forename: Chiemi
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authors.lastname: Nakayama
authors.forename: Yu
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Nobutake
authors.initials: N
authors.lastname: Yamamichi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Koike