title: A dynamic clinical pathway for the treatment of patients with early breast cancer is a tool for better cancer care: implementation and prospective analysis between 2002-2010.
abstract: BACKGROUND
  Due to increasing the complexity of breast cancer treatment it is of paramount importance to develop structured care in order to avoid a chaotic and non-consistent management of patients. Clinical pathways, a result of the adaptation of the documents used in industrial quality management namely the Standard Operating Procedures, can be used to improve efficiency and quality of care. They also aim to re-centre the focus on the patient's overall journey, rather than the contribution of each specialty or caring function independently.
  
  
  METHODS
  The effect of the implementation and prospective systematic evaluation of a clinical care pathway for the management of patients with early breast cancer in a single breast unit is evaluated over a long time interval (between 2002 and 2010). Annual analysis of predefined clinical outcome measures, service indicators, team indicators, process indicators and financial indicators was performed. Pathway quality control meetings were organized at least once a year. Systematic feedback was given to the team members, and if necessary the pathway was adapted according to evidence based literature data and in house pathway related data in order to improve quality.
  
  
  RESULTS
  The annual number of patients included in the pathway (289 vs. 390, P <0.01), proportion of patients with Tis-T1 tumors (42% vs. 58%, P <0.01), negative lymph nodes (44% vs. 58%, P <0.01) and no metastases at diagnosis (91.5% vs. 95.9%) has risen significantly between 2002 and 2010. Evolution of mandatory quality indicators defined by EUSOMA shows a significant improvement of quality of cancer care. Particularly, the proportion of patients having anti-hormonal therapy (84.8% vs. 97.4%, P = 0.002) and adjuvant chemotherapy according to the guidelines (72% vs. 95.6%, P = 0.028) increased dramatically. Patient satisfaction improved significantly (P <0.05). Progression free 4-year survival was significantly higher for all patients, for T1 tumors only and for T2-T4 tumors only, treated between 2006 to 2008 compared to between 1999 to 2002 and 2003 to 2005 (P = 0.006, P = 0.05, P = 0.06, respectively). Overall 4-year survival of the entire population treated between 2006 and 2008 was significantly better (P = 0.05).
  
  
  CONCLUSIONS
  Although the patient characteristics changed over the years due to better screening, this clinical pathway and regular audit of quality indicators for the treatment of patients with operable breast cancer proved to be important tools to improve the quality of care, patient satisfaction and outcome.
authors.affiliation: Breast Unit, Department of Gynecology, Sint-Augustinus Hospital, Wilrijk, Belgium.
authors.forename: Peter A
authors.initials: PA
authors.lastname: van Dam
authors.forename: Gerda
authors.initials: G
authors.lastname: Verheyden
authors.forename: Alessa
authors.initials: A
authors.lastname: Sugihara
authors.forename: Xuan B
authors.initials: XB
authors.lastname: Trinh
authors.forename: Herman
authors.initials: H
authors.lastname: Van Der Mussele
authors.forename: Hilde
authors.initials: H
authors.lastname: Wuyts
authors.forename: Luc
authors.initials: L
authors.lastname: Verkinderen
authors.forename: Jan
authors.initials: J
authors.lastname: Hauspy
authors.forename: Peter
authors.initials: P
authors.lastname: Vermeulen
authors.forename: Luc
authors.initials: L
authors.lastname: Dirix
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D019091:Critical Pathways / Q000458:organization & administration*; D018572:Disease-Free Survival; D019317:Evidence-Based Medicine; D005260:Female; D005500:Follow-Up Studies; D019983:Guideline Adherence / Q000639:trends*; D006801:Humans; D010348:Patient Care Team / Q000458:organization & administration*; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D019984:Quality Indicators, Health Care; D015996:Survival Rate; D013997:Time Factors