title: Serum paraoxonase-1 activity in neonatal calves: age related variations and comparison between healthy and sick animals.
abstract: Early detection of inflammation in neonatal calves allows early intervention, which may reduce mortality. Paraoxonase-1 (PON1) is a negative acute phase protein in humans. The aims of this study were to investigate age-related variability in serum PON1 activity and its clinical usefulness in neonatal calves. In healthy calves (n=9), PON1 activity increased with age from 2 to 21 days of age. There was no significant increase in PON1 activity in healthy calves from days 21 to 120 (n=15), but PON1 activity was significantly higher in adult cattle (n=45). In sick calves, serum PON1 was significantly lower in calves <7 days of age with diarrhoea (n=8) and in calves >28- to 120-days-old with respiratory disease (n=8) in comparison with age matched controls (n=20 and n=15, respectively). These results support the role of PON1 as a negative acute phase protein in cattle.
authors.affiliation: Department of Veterinary Sciences and Public Health, University of Milan, Via Celoria, 10, 21033 Milan, Italy. alessia.giordano@unimi.it
authors.forename: A
authors.initials: A
authors.lastname: Giordano
authors.forename: M C
authors.initials: MC
authors.lastname: Veronesi
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: F
authors.initials: F
authors.lastname: Pezzia
authors.forename: M
authors.initials: M
authors.lastname: Probo
authors.forename: L
authors.initials: L
authors.lastname: Giori
authors.forename: S
authors.initials: S
authors.lastname: Paltrinieri
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D043303:Aryldialkylphosphatase / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000201:enzymology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*
chemical_list: D043303:Aryldialkylphosphatase
keywords: Acute phase protein; Age; Calves; Paraoxonase-1