title: Noninvasive arterial studies including transcutaneous oxygen pressure measurements with the limbs elevated or dependent to predict healing after partial foot amputation.
abstract: OBJECTIVE
  Noninvasive arterial studies have been used to determine level of amputation. The objective of this study was to examine each component of the noninvasive arterial studies to determine optimal cut points to predict healing and to evaluate whether physiologic maneuvers could improve the utility of transcutaneous oxygen pressure (TcPO2) values to predict healing of partial foot amputation.
  
  
  METHODS
  The authors conducted a retrospective, observational study of 307 patients who underwent partial foot amputation and had noninvasive arterial studies in the perioperative period.
  
  
  RESULTS
  The TcPO2 values were significantly predictive of healing. Specifically, a cut point TcPO2 value of 38 mm Hg had a sensitivity and a specificity of 71% for predicting healing or failure. The optimal cut point was mostly unaffected by patient characteristics. The addition of noninvasive arterial studies recorded in a position with the limb elevated improved prediction in the subgroup with supine TcPO2 values of 38 mm Hg or lower.
  
  
  CONCLUSIONS
  The findings of this study validate previous reports and confirm that TcPO2 measurements are valuable to more accurately determine the correct amputation level and, in turn, obtain better outcomes. TcPO2 measurements may provide better prognostic value than do ankle-brachial indices for healing after partial foot amputation. TcPO2 measurements are useful but should not be used in isolation to make treatment decisions regarding amputation level.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Andrews
authors.forename: Mansour Y
authors.initials: MY
authors.lastname: Dib
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Shives
authors.forename: Tanya L
authors.initials: TL
authors.lastname: Hoskin
authors.forename: David A
authors.initials: DA
authors.lastname: Liedl
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: Boon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care / Q000379:methods; D000671:Amputation, Surgical / Q000379:methods*; D055109:Ankle Brachial Index / Q000379:methods*; D019540:Area Under Curve; D001785:Blood Gas Monitoring, Transcutaneous / Q000379:methods; D015331:Cohort Studies; D017719:Diabetic Foot / Q000601:surgery; D005260:Female; D005528:Foot / Q000601:surgery*; D006801:Humans; D007866:Leg / Q000098:blood supply*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D019990:Perioperative Care; D016491:Peripheral Vascular Diseases / Q000175:diagnosis / Q000601:surgery; D011237:Predictive Value of Tests; D011312:Pressure; D011379:Prognosis; D012039:Regional Blood Flow / Q000502:physiology; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D014945:Wound Healing / Q000502:physiology*