title: Application of in situ-generated Rh-bound trimethylenemethane variants to the synthesis of 3,4-fused pyrroles.
abstract: Rh-bound trimethylenemethane variants generated from the interaction of a Rh-carbenoid with an allene have been applied to the synthesis of substituted 3,4-fused pyrroles. The pyrrole products are useful starting points for the syntheses of various dipyrromethene ligands. Furthermore, the methodology has been applied to a synthesis of the natural product cycloprodigiosin, which demonstrates antitumor and immunosuppressor activity.
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: Erica E
authors.initials: EE
authors.lastname: Schultz
authors.forename: Richmond
authors.initials: R
authors.lastname: Sarpong
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D007211:Indoles; D008024:Ligands; D011758:Pyrroles; C522820:trimethylenemethane; C108328:cycloprodigiosin; D012238:Rhodium; D008697:Methane