title: SPLUNC1 regulates cell progression and apoptosis through the miR-141-PTEN/p27 pathway, but is hindered by LMP1.
abstract: Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.
authors.affiliation: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan, PR China.
authors.forename: Pan
authors.initials: P
authors.lastname: Chen
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Guo
authors.forename: Houde
authors.initials: H
authors.lastname: Zhou
authors.forename: Wenling
authors.initials: W
authors.lastname: Zhang
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Zeng
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Liao
authors.forename: Xiayu
authors.initials: X
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Xiang
authors.forename: Jianbo
authors.initials: J
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Ma
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.forename: Shuping
authors.initials: S
authors.lastname: Peng
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Xiang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Li
authors.forename: Colvin Wanshura
authors.initials: CW
authors.lastname: L E
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.forename: James B
authors.initials: JB
authors.lastname: McCarthy
authors.forename: Guiyuan
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D017209:Apoptosis; D002277:Carcinoma; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018920:Coculture Techniques; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000378:metabolism*; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000378:metabolism; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism*; D015398:Signal Transduction; D014763:Viral Matrix Proteins / Q000378:metabolism*
chemical_list: C485599:BPIFA1 protein, human; C436291:CDKN1B protein, human; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D006023:Glycoproteins; C533895:MIRN141 microRNA, human; D035683:MicroRNAs; D010750:Phosphoproteins; D014763:Viral Matrix Proteins; D049452:Green Fluorescent Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human