title: An Open-Label, Randomized Trial of Methylphenidate and Atomoxetine Treatment in Adults With ADHD.
abstract: To directly compare the efficacy of methylphenidate and atomoxetine in improving symptoms, social functions, and quality of life among adults with ADHD.
  
  
  
  This was an 8-to-10-week, open-label, head-to-head, randomized clinical trial with two treatment arms: immediate-release methylphenidate (IR-methylphenidate; n = 31) and atomoxetine once daily ( n = 32). The outcome measures included ADHD symptom severity, quality of life, and functional impairments.
  
  
  
  We found a significant reduction in overall ADHD symptoms and improvement in social functions and quality of life for both groups at Weeks 4 to 5 and Weeks 8 to 10. There was no significant difference in the slope of improvements over time except that atomoxetine was superior to IR-methylphenidate in reducing hyperactive/impulsive symptoms at Weeks 4 to 5. There was no significant group difference in the rates of adverse effects.
  
  
  
  Both IR-methylphenidate and atomoxetine are well tolerated and efficacious in ethnic Chinese adults with ADHD.
authors.affiliation: 1 National Taiwan University Hospital, Taipei, Taiwan.|2 National Taiwan University College of Medicine, Taipei, Taiwan.|3 Chang Gung Memorial Hospital at Linkou, Taiwan.
authors.forename: Hsing-Chang
authors.initials: HC
authors.lastname: Ni
authors.affiliation: 1 National Taiwan University Hospital, Taipei, Taiwan.|2 National Taiwan University College of Medicine, Taipei, Taiwan.|4 Far Eastern Memorial Hospital, Taipei, Taiwan.
authors.forename: Yu-Ju
authors.initials: YJ
authors.lastname: Lin
authors.affiliation: 1 National Taiwan University Hospital, Taipei, Taiwan.|2 National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Susan Shur-Fen
authors.initials: SS
authors.lastname: Gau
authors.affiliation: 5 National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Huang
authors.affiliation: 1 National Taiwan University Hospital, Taipei, Taiwan.|2 National Taiwan University College of Medicine, Taipei, Taiwan.|6 Beitou Armed Forces Hospital, Taipei, Taiwan.
authors.forename: Li-Kuang
authors.initials: LK
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000069445:Atomoxetine Hydrochloride / Q000008:administration & dosage* / Q000009:adverse effects; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008774:Methylphenidate / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D000069445:Atomoxetine Hydrochloride
keywords: adult ADHD; atomoxetine; life quality; methylphenidate; social function