title: Evaluation of adipokines: apelin, visfatin, and resistin in children with atopic dermatitis.
abstract: Very little is known about the role of adipokines in atopic dermatitis (AD) in children. This study aimed at analyzing the serum levels of resistin, apelin, and visfatin in children with AD in relation to body weight, AD severity, and gender. Serum concentration of adipokines was measured in 27 children with AD and in 46 healthy subjects. Selected biochemical parameters were evaluated and skin prick test was performed. Serum levels of resistin and apelin were significantly higher, whereas serum visfatin concentration was significantly lower in children with AD versus healthy controls, although an increase in resistin levels was exclusively demonstrated in boys. In AD group, a significant increase in apelin levels in girls was documented. There was no relationship between adipokines levels and the degree of allergic sensitization. Receiver operating characteristic curve analysis demonstrated that the serum apelin cutoff value differentiating children with AD from those without was >137.8 pg/mL. Resistin and visfatin cutoff values were >3.8 ng/mL and ≤ 2.13 ng/mL, respectively. Apelin and visfatin can serve as excellent indicators to distinguish children with AD from those without disease.
authors.affiliation: Department of Pediatrics, Medical University of Silesia, Ulica 3-go Maja 13-15, 41-800 Zabrze, Poland. machurae@poczta.fm
authors.forename: Edyta
authors.initials: E
authors.lastname: Machura
authors.forename: Maria
authors.initials: M
authors.lastname: Szczepanska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Ziora
authors.forename: Dariusz
authors.initials: D
authors.lastname: Ziora
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Swietochowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Barc-Czarnecka
authors.forename: Alicja
authors.initials: A
authors.lastname: Kasperska-Zajac
mesh_terms: D054392:Adipokines / Q000097:blood* / Q000378:metabolism; D000293:Adolescent; D000073861:Apelin; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood* / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000378:metabolism; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood / Q000378:metabolism; D052243:Resistin / Q000097:blood / Q000378:metabolism
chemical_list: C115436:APLN protein, human; D054392:Adipokines; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins; D052243:Resistin; D054409:Nicotinamide Phosphoribosyltransferase