title: Comparison of hematological parameters in untreated and treated subclinical hypothyroidism and primary hypothyroidism patients.
abstract: BACKGROUND
  Thyroid hormones play an important physiological role in human metabolism. Erythrocyte abnormalities are frequently associated with thyroid disorder. However, they are rarely investigated and related to the subclinical and primary hypothyroidism in Kashmiri Patients. In this study an attempt was made to study hematological parameters in untreated and treated subclinical hypothyroidism and primary hypothyroidism patients.
  
  
  METHODS
  This retrospective study included 600 subjects, among which were untreated subclinical hypothyroid (n=110), treated subclinical hypothyroid (n=110), untreated primary hypothyroid (n=100), treated primary hypothyroid (n=100) and euthyroid (n=180). This study was carried out at Department of Biochemistry, Government Medical College Srinagar. The hematological parameters and thyroid profile of the subjects were assessed by the Sysmex (Italy) and ECLIA (Germany) 2010 automatic analyzer. Mean, standard deviation (SD), analysis of variance (Two-way ANOVA), and multiple comparisons were used to report our results, with p<0.05 or p<0.01 considered as statistically significant.
  
  
  RESULTS
  In this study group we compared the hematological parameters in these groups, untreated subclinical hypothyroid, treated subclinical hypothyroid, untreated primary hypothyroid, treated primary hypothyroid and euthyroid. We found that hematological parameters like Hb, RBC, MCV, HCT, RDW,RBC% were significantly increased in untreated subclinical hypothyroidism and untreated primary hypothyroidsm, with the p value being less than 0.05 whereas, in treated SCH & Pr. Hypothyroid, results were insignificant. The results reported in these groups as mean±SD, were statistically tested by ANOVA and multiple comparison tests. In untreated subclinical hypothyroid the values were: Hb (10.83±1.33 g/dl), RBC (4.21±0.66 10(6)/µl), MCV (84.56±6.84 fL), HCT (38.5±2.2%), RDW (17.91±2.37 fL), RBC% (84.36±13.2%) and in untreated primary hypothyroid, Hb (10.73±0.86 g/dl), RBC (4.63±0.51 10(6)/µl), MCV (83.34±6.92 fL), HCT (38.6±2.6%), RDW (14.93±5.47 fL), RBC% (92.63±10.30%) suggesting that these patients were at risk of anemia and other erythrocyte abnormalities. MCV is an inexpensive approach to study the types of anemia and explore related information like production, destruction, loss and morphological changes of RBC'S.
  
  
  CONCLUSIONS
  The thyroid dysfunction is frequently associated with anemia in subclinical hypothyroidism and primary hypothyroidism. Subclinical hypothyroidism (SCH) is associated with serious complications. Substantial numbers of patients with the risk of SCH could be getting converted into primary hypothyroidism. Such conditions should be identified and corrected. On the other hand, their presence could move to a thyroid dysfunction, allowing its early management.
authors.affiliation: MSc, MPhil, Department of biochemistry, GMC, Srinagar, Kashmir, India. haamidb7@gmail.com.
authors.forename: Haamid
authors.initials: H
authors.lastname: Bashir
authors.forename: Mohmmad Hayat
authors.initials: MH
authors.lastname: Bhat
authors.forename: Rabia
authors.initials: R
authors.lastname: Farooq
authors.forename: Sabhiya
authors.initials: S
authors.lastname: Majid
authors.forename: Sheikh
authors.initials: S
authors.lastname: Shoib
authors.forename: Rabia
authors.initials: R
authors.lastname: Hamid
authors.forename: Arshed Ahmad
authors.initials: AA
authors.lastname: Mattoo
authors.forename: Tabassum
authors.initials: T
authors.lastname: Rashid
authors.forename: Arif Akbar
authors.initials: AA
authors.lastname: Bhat
authors.forename: Hilal Ahmad
authors.initials: HA
authors.lastname: Wani
authors.forename: Akbar
authors.initials: A
authors.lastname: Masood
keywords: Blood count; Hemoglobin; Mean corpuscular volume; Primary hypothyroidism; Red cell distribution; Subclinical hypothyroidism