title: Catalytic asymmetric diaziridination.
abstract: The first catalytic enantio- and diastereoselective synthesis of diaziridines is presented. Aziridination of N-tosyl aldimines applying modified hydroxylamine under asymmetric phase-transfer catalysis furnished optically active diaziridines. The diaziridines are formed as a single diastereomer in up to 96% ee, containing two orthogonal N-protecting groups, which can be deprotected selectively.
authors.affiliation: Center for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark.
authors.forename: Lennart
authors.initials: L
authors.lastname: Lykke
authors.forename: Kim Søholm
authors.initials: KS
authors.lastname: Halskov
authors.forename: Bjørn Dreiø
authors.initials: BD
authors.lastname: Carlsen
authors.forename: Victor X
authors.initials: VX
authors.lastname: Chen
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jørgensen