title: Amyloid pathology in spinal cord of the transgenic Alzheimer's disease mice is correlated to the corticospinal tract pathway.
abstract: The transgenic TgCRND8 mouse is widely used as an animal model of Alzheimer's disease (AD) and exhibits an early onset of senile plaque pathogenesis in the brain. Here we report that TgCRND8 mice also have amyloid-β (Aβ) neuropathology in spinal cord. TgCRND8 mice began to show obvious Aβ deposition in both gray matter of dorsal horn and white matter in the central part of dorsal column of the spinal cord at 10 months of age onward. Further experiments showed that the distribution of Aβ deposition in the spinal cord corresponds to the corticospinal tract pathway and its projection regions in TgCRND8 mice. We hypothesized that neurons in the sensorimotor cortex is the source of the Aβ peptide deposited in the spinal cord of these mice. To test the hypothesis, we ablated the sensorimotor cortex to interrupt connections between the sensorimotor cortex and spinal cord. We found that Aβ burden was significantly reduced in the denervated side compared to the contralateral side. Our results suggest that the sensorimotor cortex might be the primary source of Aβ in spinal cord of TgCRND8 mice. This is consistent with the observation that the sensorimotor cortex is one region particularly vulnerable during the progression of AD. The characteristics of Aβ distribution in TgCRND8 mice suggest that there are other ways related to the formation of Aβ plaques in addition to the terminal and synaptic release of Aβ.
authors.affiliation: Faculty of Science, School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T, Hong Kong SAR, China.
authors.forename: Qiuju
authors.initials: Q
authors.lastname: Yuan
authors.forename: Huanxing
authors.initials: H
authors.lastname: Su
authors.forename: Yalun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wing Hin
authors.initials: WH
authors.lastname: Chau
authors.forename: Cheung Toa
authors.initials: CT
authors.lastname: Ng
authors.forename: You-Qiang
authors.initials: YQ
authors.lastname: Song
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Huang
authors.forename: Wutian
authors.initials: W
authors.lastname: Wu
authors.forename: Zhi-Xiu
authors.initials: ZX
authors.lastname: Lin
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology*; D000682:Amyloid; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000686:Amyloidosis / Q000473:pathology; D000818:Animals; D003714:Denervation; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008822:Mice, Transgenic; D009044:Motor Cortex / Q000473:pathology; D004856:Postural Balance / Q000235:genetics / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D011712:Pyramidal Tracts / Q000473:pathology*; D013003:Somatosensory Cortex / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology*
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides