title: Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells.
abstract: Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT 06510-3221, USA. jean-leon.thomas@yale.edu
authors.forename: Jean-Leon
authors.initials: JL
authors.lastname: Thomas
authors.forename: Kasey
authors.initials: K
authors.lastname: Baker
authors.forename: Jinah
authors.initials: J
authors.lastname: Han
authors.forename: Charles
authors.initials: C
authors.lastname: Calvo
authors.forename: Harri
authors.initials: H
authors.lastname: Nurmi
authors.forename: Anne C
authors.initials: AC
authors.lastname: Eichmann
authors.forename: Kari
authors.initials: K
authors.lastname: Alitalo
mesh_terms: D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000378:metabolism; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism*; D015398:Signal Transduction; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism
chemical_list: D051880:Receptors, Notch; D042442:Vascular Endothelial Growth Factors; D040262:Receptors, Vascular Endothelial Growth Factor