title: Regulation of angiogenesis by PI3K signaling networks.
abstract: Phosphoinositide 3-kinases (PI3Ks) are an evolutionary conserved family of lipid kinases that control cell growth, metabolism and survival. By generating lipid second messengers that interact with specialized lipid-binding domains found in a wide spectrum of signaling molecules, PI3Ks instigate signaling through a network of downstream effector pathways. Genetic studies in zebrafish and mice revealed the critical importance of intact PI3K signaling in the endothelium and provided first insights into how individual PI3K isoforms are utilized to control vascular development and function. Here, we review the myriad roles of PI3Ks in the endothelium and the mechanisms through which they couple environmental signals with specific steps of angiogenic vessel growth.
authors.affiliation: Vascular Signalling Lab, Angiogenesis Unit, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL), 3a planta-Gran Via de l'Hospitalet, 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Spain. mgraupera@idibell.cat
authors.forename: Mariona
authors.initials: M
authors.lastname: Graupera
authors.forename: Michael
authors.initials: M
authors.lastname: Potente
mesh_terms: D000818:Animals; D006801:Humans; D007527:Isoenzymes / Q000502:physiology; D009369:Neoplasms / Q000098:blood supply; D009389:Neovascularization, Pathologic / Q000201:enzymology*; D018919:Neovascularization, Physiologic; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: D007527:Isoenzymes; D042461:Vascular Endothelial Growth Factor A; D019869:Phosphatidylinositol 3-Kinases; D040262:Receptors, Vascular Endothelial Growth Factor