title: Phytochemical investigation of Annulohypoxylon ilanense, an endophytic fungus derived from Cinnamomum species.
abstract: Cultivation of the fungal strain Annulohypoxylon ilanense, an endophytic fungus isolated from the wood of medicinal plant Cinnamomum species, resulted in the isolation of one new furanoid derivative, ilanefuranone (1), one new pyrrole alkaloid, ilanepyrrolal (2), and one new biarylpropanoid derivative, ilanenoid (3), together with 22 known compounds, of which one α-tetralone analog, (-)-(4R)-3,4-dihydro-4,6-dihydroxynaphthalen-1(2H)-one (4) was isolated for the first time from a natural source. The structures were elucidated on the basis of physicochemical evidence, in-depth NMR spectroscopic analysis, and high-resolution mass spectrometry, and the antimycobacterial activities were also evaluated.
authors.affiliation: Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan.
authors.forename: Ming-Der
authors.initials: MD
authors.lastname: Wu
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Yung-Shun
authors.initials: YS
authors.lastname: Su
authors.forename: Sung-Yuan
authors.initials: SY
authors.lastname: Hsieh
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Chang
authors.forename: Gwo-Fang
authors.initials: GF
authors.lastname: Yuan
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D027424:Cinnamomum / Q000382:microbiology*; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010946:Plants, Medicinal / Q000382:microbiology; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004718:Saccharomycetales / Q000737:chemistry* / Q000302:isolation & purification; D044024:Tetralones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C583435:5-((2-(4-hydroxyphenyl)ethoxy)methyl)-1H-pyrrole-2-carbaldehyde; C583434:5-(2-hydroxyethyl)-2-methyl-2-tetradecylfuran-3(2H)-one; D000470:Alkaloids; D000995:Antitubercular Agents; D005663:Furans; D011758:Pyrroles; D044024:Tetralones; D006139:Guaiacol