title: Neocortical β-amyloid area is associated with dementia and APOE in the oldest-old.
abstract: OBJECTIVE
  Apolipoprotein E (APOE) ε2 carriers may be protected from dementia because of reduced levels of cortical β-amyloid. In the oldest-old, however, APOE ε2 carriers have high β-amyloid plaque scores and preserved cognition. We compared different measures of β-amyloid pathology across APOE genotypes in the oldest-old, and their relationship with dementia.
  
  
  METHODS
  The study included 96 participants from The 90+ Study. Using all information, dementia diagnoses were made. Neuropathological examination included staging for amyloid plaques and β-amyloid cortical percent area stained by NAB228 antibody.
  
  
  RESULTS
  Both APOE ε2 and APOE ε4 carriers had high Consortium to Establish a Registry for Alzheimer's Disease plaque scores. However, APOE ε2 carriers had low cortical β-amyloid percent areas. β-amyloid percent area was associated with dementia across APOE genotypes.
  
  
  CONCLUSIONS
  Lower levels of percent area in APOE ε2 carriers may reflect lower total β-amyloid and may contribute to APOE ε2 carriers' decreased risk of dementia, despite high β-amyloid plaque scores. The relationship between β-amyloid plaques and dementia in the oldest-old may vary by APOE genotype.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Regis University, Denver, CO, USA. Electronic address: dberlau@regis.edu.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Berlau
authors.forename: María M
authors.initials: MM
authors.lastname: Corrada
authors.forename: John L
authors.initials: JL
authors.lastname: Robinson
authors.forename: Felix
authors.initials: F
authors.lastname: Geser
authors.forename: Steven E
authors.initials: SE
authors.lastname: Arnold
authors.forename: Virginia M-Y
authors.initials: VM
authors.lastname: Lee
authors.forename: Claudia H
authors.initials: CH
authors.lastname: Kawas
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
mesh_terms: D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D053329:Apolipoprotein E2 / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D003704:Dementia / Q000235:genetics* / Q000473:pathology*; D005260:Female; D005838:Genotype; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D019579:Neocortex / Q000378:metabolism*; D016874:Neurofibrillary Tangles / Q000235:genetics / Q000473:pathology; D058225:Plaque, Amyloid / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D053329:Apolipoprotein E2; D053327:Apolipoprotein E4
keywords: Alzheimer; Apolipoprotein E; Beta-amyloid; Dementia; Oldest-old