title: Markedly increased 18F-FDG uptake in a nonfunctioning adrenal adenoma mimicking malignancy.
abstract: A 63-year-old woman underwent (18)F-FDG PET/CT searching for the cause of a fever of unknown origin. (18)F-FDG PET/CT incidentally detected a focal area of markedly increased radiopharmaceutical uptake in the right adrenal gland; this finding was suspicious for an adrenal malignancy or a functioning adenoma. Nevertheless, histology and laboratory data demonstrated the presence of a nonfunctioning adenoma. This case highlights that nonfunctioning adrenal adenomas should be considered as possible false-positive (18)F-FDG PET/CT findings for malignancy in the evaluation of adrenal incidentalomas, even when marked (18)F-FDG uptake is revealed.
authors.affiliation: Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Rome, Italy. giorgiomednuc@libero.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Treglia
authors.forename: Luigi
authors.initials: L
authors.lastname: Oragano
authors.forename: Guido
authors.initials: G
authors.lastname: Fadda
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: De Gaetano
authors.forename: Marco
authors.initials: M
authors.lastname: Raffaelli
authors.forename: Vittoria
authors.initials: V
authors.lastname: Rufini
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D001692:Biological Transport; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D011859:Radiography; D011877:Radionuclide Imaging
chemical_list: D019788:Fluorodeoxyglucose F18