title: Influence of lipids on protein-mediated transmembrane transport.
abstract: Transmembrane proteins are responsible for transporting ions and small molecules across the hydrophobic region of the cell membrane. We are reviewing the evidence for regulation of these transport processes by interactions with the lipids of the membrane. We focus on ion channels, including potassium channels, mechanosensitive and pentameric ligand gated ion channels, and active transporters, including pumps, sodium or proton driven secondary transporters and ABC transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. In some cases, a combined approach of molecular and structural biology together with computer simulations has revealed the molecular mechanisms. There are also many transporters whose activity depends on lipids but understanding of the molecular mechanisms is only beginning.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, USA. denniej0@outerbanks.umaryland.edu
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Denning
authors.forename: Oliver
authors.initials: O
authors.lastname: Beckstein
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D050356:Lipid Metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D014867:Water / Q000378:metabolism
chemical_list: D007473:Ion Channels; D008565:Membrane Proteins; D014867:Water