title: Synthesis, crystal structure and biological evaluation of a main group seven-coordinated bismuth(III) complex with 2-acetylpyridine N4-phenylthiosemicarbazone.
abstract: Up to now, bismuth(III) complexes with thiosemicarbazones have been comparatively rare. Here, a main group seven-coordinated bismuth(III) complex [Bi(L)(NO3)2(CH3CH2OH)] (1) (HL = 2-acetylpyridine N(4)-phenylthiosemicarbazone) has been synthesized and characterized by elemental analysis, IR, (1)H NMR and single-crystal X-ray diffraction studies. The cytotoxicity data suggest that 1 exhibits higher in vitro antiproliferative activity in four human cancer cells tested. Its possible apoptotic mechanism has been evaluated in HepG2 cells. Compound 1 promotes a dose-dependent apoptosis in HepG2 cells and the apoptosis is associated with an increase in intracellular reactive oxygen species (ROS) production and reduction of mitochondrial membrane potential (MMP).
authors.affiliation: Henan Key Laboratory of Polyoxometalates, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, PR China.
authors.forename: Yan-Ke
authors.initials: YK
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Ming-Xue
authors.initials: MX
authors.lastname: Li
authors.forename: Han
authors.initials: H
authors.lastname: Yu
authors.forename: He-Chen
authors.initials: HC
authors.lastname: Wu
authors.forename: Song-Qiang
authors.initials: SQ
authors.lastname: Xie
mesh_terms: D001729:Bismuth / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D056831:Coordination Complexes; D011725:Pyridines; D013882:Thiosemicarbazones; C543930:2-acetylpyridine; D001729:Bismuth