title: HExpoChem: a systems biology resource to explore human exposure to chemicals.
abstract: CONCLUSIONS
  Humans are exposed to diverse hazardous chemicals daily. Although an exposure to these chemicals is suspected to have adverse effects on human health, mechanistic insights into how they interact with the human body are still limited. Therefore, acquisition of curated data and development of computational biology approaches are needed to assess the health risks of chemical exposure. Here we present HExpoChem, a tool based on environmental chemicals and their bioactivities on human proteins with the objective of aiding the qualitative exploration of human exposure to chemicals. The chemical-protein interactions have been enriched with a quality-scored human protein-protein interaction network, a protein-protein association network and a chemical-chemical interaction network, thus allowing the study of environmental chemicals through formation of protein complexes and phenotypic outcomes enrichment.
  
  
  BACKGROUND
  HExpoChem is available at http://www.cbs.dtu.dk/services/HExpoChem-1.0/.
authors.affiliation: Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark.
authors.forename: Olivier
authors.initials: O
authors.lastname: Taboureau
authors.forename: Ulrik Plesner
authors.initials: UP
authors.lastname: Jacobsen
authors.forename: Christian
authors.initials: C
authors.lastname: Kalhauge
authors.forename: Daniel
authors.initials: D
authors.lastname: Edsgärd
authors.forename: Olga
authors.initials: O
authors.lastname: Rigina
authors.forename: Ramneek
authors.initials: R
authors.lastname: Gupta
authors.forename: Karine
authors.initials: K
authors.lastname: Audouze
mesh_terms: D019295:Computational Biology / Q000379:methods; D004194:Disease; D004781:Environmental Exposure; D015386:Hazardous Substances / Q000633:toxicity*; D006801:Humans; D046912:Multiprotein Complexes / Q000187:drug effects* / Q000378:metabolism; D025941:Protein Interaction Mapping; D012984:Software; D049490:Systems Biology / Q000379:methods
chemical_list: D015386:Hazardous Substances; D046912:Multiprotein Complexes