title: [Relationship between genetic polymorphisms of 3 SNP loci in 5-HTT gene and paranoid schizophrenia].
abstract: OBJECTIVE
  To investigate the population genetic data of 3 SNP loci (rs25533, rs34388196 and rs1042173) of 5-hydroxytryptamine transporter (5-HTT) gene and the association with paranoid schizophrenia.
  
  
  METHODS
  Three SNP loci of 5-HTT gene were examined in 132 paranoid schizophrenia patients and 150 unrelated healthy individuals of Northern Chinese Han population by PCR-RFLP technique. The Hardy-Weinberg equilibrium test was performed using the chi-square test and the data of haplotype frequency and population genetics parameters were statistically analyzed.
  
  
  RESULTS
  Among these three SNP loci, four haplotypes were obtained. There were no statistically significant differences between the patient group and the control group (P > 0.05). The DP values of the 3 SNP loci were 0.276, 0.502 and 0.502. The PIC of them were 0.151, 0.281 and 0.281. The PE of them were 0.014, 0.072 and 0.072.
  
  
  CONCLUSIONS
  The three SNP loci and four haplotypes of 5-HTT gene have no association with paranoid schizophrenia, while the polymorphism still have high potential application in forensic practice.
authors.affiliation: School of Forensic Medicine, China Medical University, Shenyang 110001, China.
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Xuan
authors.forename: Mei
authors.initials: M
authors.lastname: Ding
authors.forename: Hao
authors.initials: H
authors.lastname: Pang
authors.forename: Jia-Xin
authors.initials: JX
authors.lastname: Xing
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Li
authors.forename: Bao-Jie
authors.initials: BJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012563:Schizophrenia, Paranoid / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins