title: Novel water-soluble (99m)Tc(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging.
abstract: The synthesis and characterization of two novel water soluble porphyrins with three meso pyridyl rings and one peripheral chelator - either a diethylenetriamine unit (4) or a bipyridyl fragment (8) - for binding to the {(99m)Tc(CO)3}(+) moiety is reported. In 8, despite the presence of a flexible and hydrophilic PEG-like linker that connects the bpy unit to the macrocycle, good water solubility was only obtained by methylation of the pyridyl N atoms that provided three extra positive charges. Furthermore, the water-soluble conjugates of 4 and 8 with either one fac-{Re(CO)3}(+) (9 and 10, respectively) or one fac-{(99m)Tc(CO)3}(+) fragment (9a and 10a, respectively) are described.
authors.affiliation: Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Spagnul
authors.forename: Roger
authors.initials: R
authors.lastname: Alberto
authors.forename: Gilles
authors.initials: G
authors.lastname: Gasser
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrari
authors.forename: Vanessa
authors.initials: V
authors.lastname: Pierroz
authors.forename: Alberta
authors.initials: A
authors.lastname: Bergamo
authors.forename: Teresa
authors.initials: T
authors.lastname: Gianferrara
authors.forename: Enzo
authors.initials: E
authors.lastname: Alessio
mesh_terms: D002851:Chromatography, High Pressure Liquid; D057054:Molecular Imaging; D015394:Molecular Structure; D015609:Organotechnetium Compounds / Q000138:chemical synthesis; D011166:Porphyrins / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*; D012995:Solubility; D013667:Technetium / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D015609:Organotechnetium Compounds; D011166:Porphyrins; D014867:Water; D012211:Rhenium; D013667:Technetium