title: Investigation on the interaction behavior between curcumin and PAMAM dendrimer by spectral and docking studies.
abstract: The interactions between PAMAM-C12 25% and curcumin were studied by UV/vis, fluorescence spectroscopy, and molecular modeling methods. The experimental results showed that the formation of PAMAM-C12 25%@curcumin non-covalent adduct induced the fluorescence quenching of PAMAM-C12 25%; Curcumin entered the interface of PAMAM-C12 25% with mainly five classes of binding sites by hydrophobic, hydrogen bonds, and van der Waals forces interactions. The bigger values of binding constants indicated that PAMAM-C12 25% hold the curcumin tightly.
authors.affiliation: Institute of Applied Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng City, Jiangsu Province 224002, People's Republic of China. yctu_caojian@126.com
authors.forename: Jian
authors.initials: J
authors.lastname: Cao
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhang
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Wang
authors.forename: Jinming
authors.initials: J
authors.lastname: Yang
authors.forename: Fuguang
authors.initials: F
authors.lastname: Jiang
mesh_terms: D000042:Absorption; D003474:Curcumin / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D007700:Kinetics; D062105:Molecular Docking Simulation; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
chemical_list: D050091:Dendrimers; C104700:PAMAM Starburst; D003474:Curcumin