title: Association study of rs6812193 polymorphism with Parkinson's disease in a Greek population.
abstract: In a recent web based genome-wide association study (GWA) the rs6812193 polymorphism was identified as a new risk factor for Parkinson's disease (PD). The purpose of our study was to examine the association of the rs6812193 polymorphism with Parkinson's disease (PD) in case-control association study of Greek individuals. We studied a total of 343 individuals, 210 Greek patients with sporadic PD and 133 control subjects, using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We found no differences in genotype or allele frequencies between PD patients and controls (P=0.795 and P=0.892, respectively), suggesting that the rs6812193 polymorphism does not increase susceptibility to PD in the Greek population. Additional studies further investigating the association of the rs6812193 polymorphism with PD are needed in order to clarify the role of this polymorphism in different ethnicities.
authors.affiliation: Department of General Biology, Medical School, Aristotle University of Thessaloniki, GR-54124, Thessaloniki, Greece.
authors.forename: Kallirhoe
authors.initials: K
authors.lastname: Kalinderi
authors.forename: Sevasti
authors.initials: S
authors.lastname: Bostantjopoulou
authors.forename: Zoe
authors.initials: Z
authors.lastname: Katsarou
authors.forename: Liana
authors.initials: L
authors.lastname: Fidani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006115:Greece; D006801:Humans; D051907:Lysosomal Membrane Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D051116:Receptors, Scavenger / Q000235:genetics*
chemical_list: D051907:Lysosomal Membrane Proteins; D051116:Receptors, Scavenger; C074299:SCARB2 protein, human