title: Using high frequency Raman spectra for colonic neoplasia detection.
abstract: Raman systems have tremendous potential as adjunct devices for endoscopes to improve the identification of early colon cancers. However, the traditional low frequency (LF) measurement range has several obstacles that make it challenging to develop a routine clinical tool. An alternative is to use high frequency (HF) range. To test this idea Raman spectra were obtained in both the LF and HF ranges from the same colon lesions. Multivariate analyses predicted the pathology with high sensitivity and specificity for both the LF and HF data sets. This suggests that Raman systems that measure HF spectra, and are simpler to adopt into the clinic, could be used in vivo to improve the identification of neoplastic lesions.
authors.affiliation: Imaging Unit - Integrative Oncology Department, British Columbia Cancer Agency Research Centre, 675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Short
authors.forename: Isabella T
authors.initials: IT
authors.lastname: Tai
authors.forename: David
authors.initials: D
authors.lastname: Owen
authors.forename: Haishan
authors.initials: H
authors.lastname: Zeng
mesh_terms: D000465:Algorithms; D003110:Colonic Neoplasms / Q000175:diagnosis*; D003627:Data Interpretation, Statistical; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman / Q000379:methods*