title: An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells.
abstract: One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.
authors.affiliation: INSERM, U848; Villejuif, France ; Institut Gustave Roussy; Villejuif, France ; Université Paris Sud/Paris XI; Le Kremlin Bicêtre, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Senovilla
authors.forename: Ilio
authors.initials: I
authors.lastname: Vitale
authors.forename: Isabelle
authors.initials: I
authors.lastname: Martins
authors.forename: Oliver
authors.initials: O
authors.lastname: Kepp
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
authors.forename: Maria
authors.initials: M
authors.lastname: Castedo
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
keywords: HMGB1; breast carcinoma; calreticulin; hyperploidy; immunogenic cell death; mitotic catastrophe