title: Ayurvedic drug discovery.
abstract: Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested evidences vouch immense therapeutic benefits for ayurvedic herbs and formulations, several important issues are required to be resolved for successful implementation of ayurvedic principles to present drug discovery methodologies. Additionally, clinical examination in the extent of efficacy, safety and drug interactions of newly developed ayurvedic drugs and formulations are required to be carefully evaluated. Ayurvedic experts suggest a reverse-pharmacology approach focusing on the potential targets for which ayurvedic herbs and herbal products could bring tremendous leads to ayurvedic drug discovery. Although several novel leads and drug molecules have already been discovered from ayurvedic medicinal herbs, further scientific explorations in this arena along with customization of present technologies to ayurvedic drug manufacturing principles would greatly facilitate a standardized ayurvedic drug discovery.
authors.affiliation: University of Mississippi, National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, MS 38677, USA +1 662 915 3463 ; +1 662 915 7062 ; prembala@olemiss.edu.
authors.forename: Premalatha
authors.initials: P
authors.lastname: Balachandran
authors.forename: Rajgopal
authors.initials: R
authors.lastname: Govindarajan