title: The association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults.
abstract: BACKGROUND
  Chemerin is a recently discovered adipocytokine, associated with adiposity and insulin sensitivity. The current study investigated the effects of lifestyle intervention on circulating chemerin level and its association with insulin resistance and adiponectin in human.
  
  
  METHODS
  Forty male and 20 female obese adults (mean age: 29.7±5.7 y, mean BMI: 29.3±4.5 kg/m(2)) completed an 8-week lifestyle intervention program, which consisted of a home-based diet and exercise program. Anthropometric measurements and biomarkers were assessed at the baseline and at the end of the study.
  
  
  RESULTS
  Eight weeks of lifestyle intervention reduced body weight, visceral fat and subcutaneous fat by 3.8%, 15.3% and 11.5%, respectively. The lifestyle intervention further reduced fasting insulin (10.9±6.6 vs. 7.6±5.3 μU/ml, p<0.001) and homeostasis assessment of insulin resistance (HOMA-IR) (2.3±1.5 vs. 1.6±1.2, p<0.001), chemerin (103.3±20.7 vs. 96.5±19.5 ng/ml, p<0.001) and hs-CRP levels (1.3±1.8 vs. 0.2±0.2 mg/dl, p<0.001) while it increased fasting pentraxin (PTX) 3 (0.6±0.7 vs. 0.7±0.4 ng/ml, p=0.049) level. The Δ chemerin levels correlated with Δ insulin (r=0.349, p=0.024) and HOMA-IR (r=0.333, p=0.36) even after adjusting for age and gender.
  
  
  CONCLUSIONS
  The lifestyle intervention reduced circulating chemerin levels independent of visceral fat mass and adiponectin. Chemerin levels are associated with insulin resistance at the baseline and after the lifestyle intervention.
authors.affiliation: Department of Sport and Leisure Studies, Sport Medicine Laboratory, Yonsei University, Seoul, Republic of Korea.
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Sang Hui
authors.initials: SH
authors.lastname: Chu
authors.forename: Duk Chul
authors.initials: DC
authors.lastname: Lee
authors.forename: Ki Yong
authors.initials: KY
authors.lastname: An
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Park
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Kim
authors.forename: Jiyoung
authors.initials: J
authors.lastname: Kim
authors.forename: Sunghyun
authors.initials: S
authors.lastname: Hong
authors.forename: Jee Aee
authors.initials: JA
authors.lastname: Im
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Justin Y
authors.initials: JY
authors.lastname: Jeon
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D018925:Chemokines / Q000097:blood*; D015444:Exercise; D005215:Fasting; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology; D008019:Life Style; D008297:Male; D009765:Obesity / Q000097:blood* / Q000473:pathology; D050151:Subcutaneous Fat / Q000378:metabolism / Q000473:pathology; D015431:Weight Loss
chemical_list: D052242:Adiponectin; D018925:Chemokines; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; D002097:C-Reactive Protein