title: Prostate cancer detection at repeat biopsy: can pelvic phased-array multiparametric MRI replace saturation biopsy?
abstract: OBJECTIVE
  Magnetic resonance imaging (MRI) accuracy in prostate cancer (PCa) diagnosis in men submitted to saturation prostate biopsy (SPBx) was evaluated.
  
  
  METHODS
  From June 2011 to December 2012, 78 patients (median 63 years) underwent repeat SPBx (median 28 cores). Multiparametric MRI using a 3 Tesla pelvic phased-array coil was performed before SPBx and lesions suspicious for PCa were submitted to additional targeted biopsies.
  
  
  RESULTS
  A T1c PCa was found in 32 (41%) cases. SPBx vs. MRI-suspicious targeted biopsy diagnosed 28 (87.5%) vs. 26 (81.2%) PCa missing four (12.5%) and six (18.8%) cancers localized in the anterior zone and in the lateral margin of the prostate, respectively; moreover, MRI diameter lesions correlated with PCa diagnosis and Gleason score (p<0.05).
  
  
  CONCLUSIONS
  Multiparametric MRI improved SPBx accuracy in diagnosing PCa of the anterior zone; moreover, suspicious areas >10 mm resulted as highly predictive of cancer (about 70% of the cases).
authors.affiliation: Urology Unit, Cannizzaro Hospital, via Messina 829, Catania, Italy. piepepe@hotmail.com
authors.forename: Pietro
authors.initials: P
authors.lastname: Pepe
authors.forename: Antonio
authors.initials: A
authors.lastname: Garufi
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Priolo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Candiano
authors.forename: Francesco
authors.initials: F
authors.lastname: Pietropaolo
authors.forename: Michele
authors.initials: M
authors.lastname: Pennisi
authors.forename: Filippo
authors.initials: F
authors.lastname: Fraggetta
authors.forename: Francesco
authors.initials: F
authors.lastname: Aragona
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis*