title: [Oligodendrocyte and spinal cord injury].
abstract: Spinal cord injury (SCI) is frequently companied by necrosis and apoptosis of oligodendrocytes (OLs), which contributes to demyelination of myelinated nerve fibers and their electrophysiological defects. This pathological demyelination often results in sensory or motor deficits. Here, we first focus on the microenvironment changes after SCI that cause OLs' death, then discuss the major mechanism of endogenous oligodendrocytogenesis and axonal remyelination, and finally summarize current therapies targeting OLs protection and replacement.
authors.affiliation: Basic Medicine and Forensic Medicine of West China School, Sichuan University, Chengdu 610041, China.
authors.forename: Huayan
authors.initials: H
authors.lastname: Xu
authors.forename: Junjuan
authors.initials: J
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhai
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.forename: Xue
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D006801:Humans; D009336:Necrosis / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009416:Nerve Regeneration / Q000502:physiology; D009836:Oligodendroglia / Q000473:pathology*; D013116:Spinal Cord / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy