title: Novel indole alkaloids from Nauclea latifolia and their renin-inhibitory activities.
abstract: Chemical studies on the crude MeOH extract of stems and barks of Nauclea latifolia resulted in the isolation of five new indole alkaloids, latifoliamides A-E (1-5, resp.), along with one known alkaloid, angustoline (6). The structures of these compounds were elucidated by means of extensive NMR spectral studies. Compound 1 has a 20-ethylidenetetrahydrofuran ring incorporated in its structure and represents the first example of this class of indole alkaloids. All of the isolates exhibited moderate in vitro renin inhibitory activities.
authors.affiliation: Department of Biology, Richardson College for the Environmental and Science Complex, The University of Winnipeg, 599 Portage Ave., Winnipeg, MB, Canada R3B 2G3.
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Agomuoh
authors.forename: Athar
authors.initials: A
authors.lastname: Ata
authors.forename: Chibuike C
authors.initials: CC
authors.lastname: Udenigwe
authors.forename: Rotimi E
authors.initials: RE
authors.lastname: Aluko
authors.forename: Iwu
authors.initials: I
authors.lastname: Irenus
mesh_terms: D000577:Amides / Q000737:chemistry / Q000302:isolation & purification; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012083:Renin / Q000378:metabolism; D019666:Rubiaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship; D000092502:Renin Inhibitors
chemical_list: D000577:Amides; D026121:Indole Alkaloids; D012083:Renin; D000092502:Renin Inhibitors