title: Dynamic resolution of lithiated ortho-trifluoromethyl styrene oxide and the effect of chiral diamines on the barrier to enantiomerisation.
abstract: The first dynamic thermodynamic resolution of a racemic oxiranyllithium is described with selectivities of up to 82 : 18 from a selection of three types of chiral ligands (seven ligands in total). Both (-)-sparteine and its (+)-surrogate were surprisingly found to increase the enantiomerisation barrier.
authors.affiliation: Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari Aldo Moro, Consorzio C.I.N.M.P.I.S., via E. Orabona 4, I-70125 Bari, Italy.
authors.forename: Rosmara
authors.initials: R
authors.lastname: Mansueto
authors.forename: Filippo Maria
authors.initials: FM
authors.lastname: Perna
authors.forename: Antonio
authors.initials: A
authors.lastname: Salomone
authors.forename: Saverio
authors.initials: S
authors.lastname: Florio
authors.forename: Vito
authors.initials: V
authors.lastname: Capriati
mesh_terms: D003959:Diamines / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D018020:Lithium Compounds / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013034:Sparteine / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003959:Diamines; D004852:Epoxy Compounds; D018020:Lithium Compounds; D009942:Organometallic Compounds; D013034:Sparteine; C013690:styrene oxide