title: Evaluation of factors that motivate participants to consent for non-therapeutic trials in India.
abstract: OBJECTIVE
  Several factors that motivate individuals to participate in non-therapeutic studies have been identified. This study was conducted as limited data is available regarding these motivations from developing countries.
  
  
  METHODS
  This was a single-centre study conducted over 4 months in which a questionnaire was administered to 102 healthy participants and 16 patient participants who had earlier taken part in non-therapeutic studies at our centre. Descriptive statistics and univariate analysis were used to analyse data.
  
  
  RESULTS
  The most common motivation among healthy participants was financial reward (65%) followed by altruism, free medical check up, curiosity and personal health benefit. Patient participants, however, most commonly said they consented to take part in the trial as they were 'invited to participate by the treating physician' (88%). In comparison with the patient participants, healthy participants were more likely to be satisfied with the financial reward (p=0.02), and recommend participation in studies to friends or relatives (p=0.0013).
  
  
  CONCLUSIONS
  The most common motivating factor to participate in non-therapeutic studies appears to be different for healthy participants (financial reward) and patient participants (invitation to participate by the physician). Participants also felt that adequate information and care was given to them during the trial, and that they would participate in future clinical studies, and would also recommend such studies to their friends.
authors.affiliation: Department of Clinical Pharmacology, 1st Floor, MSB, Seth GS Medical College and KEM Hospital, Acharya Donde Marg, Parel, Mumbai, Maharashtra 400012, India. urmilathatte@gmail.com
authors.forename: Maulik Sumantbhai
authors.initials: MS
authors.lastname: Doshi
authors.forename: Shaunak P
authors.initials: SP
authors.lastname: Kulkarni
authors.forename: Canna J
authors.initials: CJ
authors.lastname: Ghia
authors.forename: Nithya J
authors.initials: NJ
authors.lastname: Gogtay
authors.forename: Urmila Mukund
authors.initials: UM
authors.lastname: Thatte
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003906:Developing Countries; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009042:Motivation; D033281:Nontherapeutic Human Experimentation; D010361:Patients / Q000523:psychology; D010819:Physician's Role; D010817:Physician-Patient Relations; D060926:Remuneration; D035842:Research Subjects / Q000523:psychology; D012201:Reward; D011795:Surveys and Questionnaires
keywords: Informed Consent