title: Synthesis and cellular compatibility of biomineralized Fe3O4 nanoparticles in tumor cells targeting peptides.
abstract: Fe3O4 nanoparticles (NPs) coated with WSG-peptide were prepared via a facile biomineralization technique at room temperature. The concentration of the peptides and the mixing time could substantially influence the morphology of as-prepared particles. The saturation magnetization of WSG-coated Fe3O4 particles were 35.92 emu/g, slightly higher than that of Fe3O4 without WSG peptides. Cell viability assay revealed that WSG-coated Fe3O4 particles had a good cellular compatibility. In addition, compared with Fe3O4 NPs, the mineralized Fe3O4 NPs coated with WSG peptides could more easily assemble into the cancer cell, indicating that the WSG-Fe3O4 NPs possess cancer targeting property. Thus, the WSG-coated Fe3O4 NPs could be used in cancer diagnosis and treatment fields.
authors.affiliation: College of Materials Science and Engineering, Sichuan University, Chengdu 610065, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wei
authors.forename: Guangfu
authors.initials: G
authors.lastname: Yin
authors.forename: Chuying
authors.initials: C
authors.lastname: Ma
authors.forename: Zhongbing
authors.initials: Z
authors.lastname: Huang
authors.forename: Xianchun
authors.initials: X
authors.lastname: Chen
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Liao
authors.forename: Yadong
authors.initials: Y
authors.lastname: Yao
authors.forename: Hao
authors.initials: H
authors.lastname: Yin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002152:Calorimetry, Differential Scanning; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D052203:Ferrosoferric Oxide / Q000138:chemical synthesis* / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D060328:Magnetic Phenomena; D051379:Mice; D008903:Minerals / Q000494:pharmacology*; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D008903:Minerals; D010455:Peptides; D052203:Ferrosoferric Oxide