title: Long noncoding RNAs: cellular address codes in development and disease.
abstract: In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code--how objects are placed and later searched for and retrieved. Long noncoding RNAs (lncRNAs) have emerged as key components of the address code, allowing protein complexes, genes, and chromosomes to be trafficked to appropriate locations and subject to proper activation and deactivation. lncRNA-based mechanisms control cell fates during development, and their dysregulation underlies some human disorders caused by chromosomal deletions and translocations.
authors.affiliation: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Batista
authors.forename: Howard Y
authors.initials: HY
authors.lastname: Chang
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry* / Q000235:genetics; D004194:Disease / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D062085:RNA, Long Noncoding / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: D062085:RNA, Long Noncoding