title: An unusual unifocal presentation of Castleman's disease in a young woman with a detailed description of sonographic findings to reduce diagnostic uncertainty: a case report.
abstract: BACKGROUND
  Castleman's disease is a rare lymphoproliferative disorder. It typically presents as mediastinal masses and causes a wide range of clinical symptoms. Histologically, Castleman's disease is classified as either a hyalinic vascular or plasma cell variant. The prognosis mainly depends on the histological type and broadly varies. We herein report our sonographic findings in a patient with Castleman's disease, including gray-scale ultrasonography, color Doppler ultrasonography, and sonoelastography ultrasonography, which have not been previously reported in the literature. These findings allowed for a preoperative diagnosis and avoidance of overly aggressive therapy.
  
  
  METHODS
  A 28-year-old European female patient with unicentric Castleman's disease of hyalinic vascular type (HV) restricted to the axilla was referred to us because of a 4-month history of a painless, solitary mass located in the left axilla. The patient's medical history was unremarkable.
  
  
  CONCLUSIONS
  Castleman's disease is a pathologic entity of unknown etiology and pathogenesis. In this case report of unicentric HV-type CD, we demonstrate that typical sonographic findings can lead to a preoperative diagnosis of Castleman's disease. Core needle biopsy usually allows for a final diagnosis and helps to avoid unnecessary operations and overtreatment.
authors.affiliation: Department of Obstetrics and Gynecology, Marienhospital Essen, Hospitalstrasse 24, Essen 45329, Germany. norbertwausu@yahoo.de
authors.forename: Norbert
authors.initials: N
authors.lastname: Wagner
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Maden
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D018615:Ultrasonography, Doppler, Color; D035501:Uncertainty