title: Organohalide respiration: microbes breathing chlorinated molecules.
abstract: Bacterial respiration has taken advantage of almost every redox couple present in the environment. The reduction of organohalide compounds to release the reduced halide ion drives energy production in organohalide respiring bacteria. This process is centred around the reductive dehalogenases, an iron-sulfur and corrinoid containing family of enzymes. These enzymes, transcriptional regulators and the bacteria themselves have potential to contribute to future bioremediation solutions that address the pollution of the environment by halogenated organic compounds.
authors.affiliation: Manchester Institute of Biotechnology, University of Manchester, MIB 131 Princess Street, Manchester, UK. david.leys@manchester.ac.uk
authors.forename: David
authors.initials: D
authors.lastname: Leys
authors.forename: Lorenz
authors.initials: L
authors.lastname: Adrian
authors.forename: Hauke
authors.initials: H
authors.lastname: Smidt
mesh_terms: D001419:Bacteria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001673:Biodegradation, Environmental; D004147:Dioxins / Q000378:metabolism; D004579:Electron Transport; D005798:Genes, Bacterial; D054879:Halogenation; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D014158:Transcription, Genetic; D014871:Water Microbiology
chemical_list: D001426:Bacterial Proteins; D004147:Dioxins; D010100:Oxygen