title: Neonatal infectious diseases: evaluation of neonatal sepsis.
abstract: Neonatal sepsis remains a feared cause of morbidity and mortality in the neonatal period. Maternal, neonatal, and environmental factors are associated with risk of infection, and a combination of prevention strategies, judicious neonatal evaluation, and early initiation of therapy are required to prevent adverse outcomes. This article reviews recent trends in epidemiology and provides an update on risk factors, diagnostic methods, and management of neonatal sepsis.
authors.affiliation: Division of Pediatric Infectious Diseases, Emory Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA. acamac2@emory.edu
authors.forename: Andres
authors.initials: A
authors.lastname: Camacho-Gonzalez
authors.forename: Paul W
authors.initials: PW
authors.lastname: Spearman
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Stoll
mesh_terms: D056704:Adaptive Immunity; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001424:Bacterial Infections / Q000150:complications; D015415:Biomarkers / Q000097:blood*; D001772:Blood Cell Count; D002097:C-Reactive Protein / Q000378:metabolism; D002177:Candidiasis / Q000150:complications; D004927:Escherichia coli Infections / Q000150:complications* / Q000276:immunology; D015725:Fluconazole / Q000008:administration & dosage; D023281:Genomics; D006801:Humans; D007113:Immunity, Innate; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D007781:Lactoferrin / Q000008:administration & dosage; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D040901:Proteomics; D012307:Risk Factors; D018805:Sepsis / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D013290:Streptococcal Infections / Q000150:complications* / Q000276:immunology; D013292:Streptococcus agalactiae / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D000911:Antibodies, Monoclonal; D000935:Antifungal Agents; D015415:Biomarkers; D016756:Immunoglobulins, Intravenous; D015725:Fluconazole; D002097:C-Reactive Protein; D007781:Lactoferrin