title: Restenosis treatments using nanoparticle-based drug delivery systems.
abstract: Restenosis, the re-narrowing of a blood vessel after removal of atherosclerotic plaque, is a major limitation of surgical treatments for atherosclerosis. Various attempts to prevent or treat restenosis by pharmacological or mechanical approaches have had limited success in clinical trials. Hence, there is wide interest in developing new strategies to prevent or treat restenosis. This review discusses 'a new-generation therapy' that uses functional nanoparticles to effectively deliver active drug molecules. The potential platforms for nanoparticle-based solutions to restenosis include organic (e.g. polymers, liposomes, and proteins) and inorganic nanoparticles (e.g. layered double hydroxides, titanium oxide nanotubes, and magnetic nanoparticles,). Many in vitro and in vivo studies based on these platforms demonstrate the feasibility and potential of using nanoparticle drug delivery systems for preventing or treating restenosis, but as yet few have reached clinical trials. It is suggested that using inorganic nanoparticles to target deliver multi-functional drugs will be a promising approach to preventing or treating restenosis.
authors.affiliation: ARC Centre of Excellence for Functional Nanomaterials, Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia. gordonxu@uq.edu.au.
authors.forename: Zi
authors.initials: Z
authors.lastname: Gu
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Rolfe
authors.forename: Anita C
authors.initials: AC
authors.lastname: Thomas
authors.forename: Zhi Ping
authors.initials: ZP
authors.lastname: Xu
mesh_terms: D000818:Animals; D023903:Coronary Restenosis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D008081:Liposomes; D053758:Nanoparticles; D043942:Nanotubes; D011108:Polymers / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D014025:Titanium / Q000737:chemistry
chemical_list: D008081:Liposomes; D011108:Polymers; D011506:Proteins; C009495:titanium dioxide; D014025:Titanium