title: T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment.
abstract: Recently, we reported the accumulation of CD4+FOXP3+regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression mediated by TiTregs.
authors.affiliation: Department of Gastroenterology and Hepatology; Erasmus MC-University Medical Center; Rotterdam, The Netherlands.
authors.forename: Alexander
authors.initials: A
authors.lastname: Pedroza-Gonzalez
authors.forename: Jaap
authors.initials: J
authors.lastname: Kwekkeboom
authors.forename: Dave
authors.initials: D
authors.lastname: Sprengers
keywords: GITRL; T cells; colorectal cancer; hepatocellular carcinoma; immunotherapy; liver cancer; liver metastasis; regulatory T cells