title: Accuracy of positron emission tomography/computed tomography in the diagnosis and restaging for recurrent ovarian cancer: a meta-analysis.
abstract: OBJECTIVE
  A meta-analysis was performed to estimate the diagnostic accuracy of positron emission tomography/computed tomography (PET/CT) in suspected recurrent ovarian cancer.
  
  
  METHODS
  PubMed, The Cochrane Library, Embase, and Web of Science were systematically searched. Studies that compared PET/CT and reference standards within patients for diagnosis of suspected recurrent ovarian cancer were included.
  
  
  RESULTS
  Twenty-nine studies involving 1651 patients with ovarian cancer were analyzed. For recurrent versus nonrecurrent ovarian cancer, the pooled sensitivity, specificity, positive likelihood (LH) ratio, negative LH ratio, and diagnostic odds ratio of ovarian carcinoma were 88.6% (95% confidence interval [CI], 86.6%-90.3%), 90.3% (95% CI, 87.6%-92.7%), 6.104 (95% CI, 3.904-9.543), 0.122 (95% CI, 0.077%-0.192%), and 57.032 (95% CI, 30.764-105.73), respectively, for recurrence in the PET/CT. Because sensitivity, specificity, positive LH ratio, and negative LH ratio were all heterogeneous, random effects model was used, and a summary receiver operating characteristic curve was generated. The area under the curve was 0.9445 for recurrent versus nonrecurrent ovarian cancer.
  
  
  CONCLUSIONS
  Positron emission tomography/computed tomography is a useful tool for predicting the diagnosis and restaging of suspected recurrent ovarian carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Limei
authors.forename: Chen
authors.initials: C
authors.lastname: Yong
authors.forename: Xu
authors.initials: X
authors.lastname: Yan
authors.forename: Tang
authors.initials: T
authors.lastname: Shuai
authors.forename: Xie
authors.initials: X
authors.lastname: Jiangyan
authors.forename: Liang
authors.initials: L
authors.lastname: Zhiqing
mesh_terms: D002277:Carcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D064847:Multimodal Imaging; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000000981:diagnostic imaging*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging