title: Biodegradable β-tricalcium phosphate cement with anti-washout property based on chelate-setting mechanism of inositol phosphate.
abstract: Novel biodegradable β-tricalcium phosphate (β-TCP) cements with anti-washout properties were created on the basis of chelate-setting mechanism of inositol phosphate (IP6) using β-TCP powders. The β-TCP powders were ball-milled using ZrO₂ beads for 0-6 h in the IP6 solutions with concentrations from 0 to 10,000 ppm. The chelate-setting β-TCP cement with anti-washout property was successfully fabricated by mixing the β-TCP powder ball-milled in 3,000 ppm IP6 solution for 3 h and 2.5 mass% Na₂HPO₄ solution, and compressive strength of the cement was 13.4 ± 0.8 MPa. An in vivo study revealed that the above cement was directly in contact with host and newly formed bones without fibrous tissue layers, and was resorbed by osteoclast-like cells on the surface of the cement. The chelate-setting β-TCP cement with anti-washout property is promising for application as a novel injectable artificial bone with both biodegradability and osteoconductivity.
authors.affiliation: Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan. ap-konishi@newkast.or.jp
authors.forename: Toshiisa
authors.initials: T
authors.lastname: Konishi
authors.forename: Shuhei
authors.initials: S
authors.lastname: Takahashi
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhuang
authors.forename: Kohei
authors.initials: K
authors.lastname: Nagata
authors.forename: Minori
authors.initials: M
authors.lastname: Mizumoto
authors.forename: Michiyo
authors.initials: M
authors.lastname: Honda
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Hitomi
authors.initials: H
authors.lastname: Matsunari
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagashima
authors.forename: Mamoru
authors.initials: M
authors.lastname: Aizawa
mesh_terms: D020341:Absorbable Implants; D000268:Adhesiveness; D000818:Animals; D001843:Bone Cements / Q000737:chemistry* / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000737:chemistry* / Q000627:therapeutic use*; D002478:Cells, Cultured; D006244:Hardness; D007295:Inositol Phosphates / Q000737:chemistry*; D008422:Materials Testing; D016348:Osseointegration / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects*; D011208:Powders; D013552:Swine; D013978:Tibial Fractures / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D007295:Inositol Phosphates; D011208:Powders; C485817:beta-tricalcium phosphate