title: In vivo antitumour activity of amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B.
abstract: We explore the possible cellular cytotoxic activity of an amphiphilic silicon(IV) phthalocyanine with axially ligated rhodamine B under ambient light experimental environment as well as its in vivo antitumour potential using Hep3B hepatoma cell model. After loading into the Hep3B hepatoma cells, induction of cellular cytotoxicity and cell cycle arrest were detected. Strong growth inhibition of tumour xenograft together with significant tumour necrosis and limited toxicological effects exerted on the nude mice could be identified.
authors.affiliation: Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, China.
authors.forename: Zhinxin
authors.initials: Z
authors.lastname: Zhao
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Kenneth Ka-Ho
authors.initials: KK
authors.lastname: Lee
authors.forename: Stanton Hon-Lung
authors.initials: SH
authors.lastname: Kok
authors.forename: Raymond Siu-Ming
authors.initials: RS
authors.lastname: Wong
authors.forename: Fung-Yi
authors.initials: FY
authors.lastname: Lau
authors.forename: Johnny Cheuk-On
authors.initials: JC
authors.lastname: Tang
authors.forename: Kim-Hung
authors.initials: KH
authors.lastname: Lam
authors.forename: Chor-Hing
authors.initials: CH
authors.lastname: Cheng
authors.forename: Desmond Kwok Po
authors.initials: DK
authors.lastname: Hau
authors.forename: Chung-Hin
authors.initials: CH
authors.lastname: Chui
authors.forename: Wai-Yeung
authors.initials: WY
authors.lastname: Wong
authors.forename: Wai-Kwok
authors.initials: WK
authors.lastname: Wong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D054833:Isoindoles; D008113:Liver Neoplasms / Q000188:drug therapy; D051379:Mice; D008819:Mice, Nude; D011897:Random Allocation; D012235:Rhodamines / Q000737:chemistry* / Q000494:pharmacology*; D012825:Silicon / Q000737:chemistry / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D054833:Isoindoles; D012235:Rhodamines; C029773:rhodamine B; C013647:phthalocyanine; D012825:Silicon