title: Birth defects after incestuous mating: calculating the probability of causality and reflecting on the desirability of genetic testing.
abstract: In this short communication we (1) show that, despite the rarity of autosomal recessive inheritance, primary congenital hydrocephalus in a girl stemming from father-daughter incest is most likely due to the incestuous union of her parents, and (2) reflect on the question, among others, whether actual genetic work-up to support victim indemnification is ever in the interest of the child.
authors.affiliation: Department of Clinical Genetics and Institute of Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. lp.tenkate@vumc.nl
authors.forename: Leo P
authors.initials: LP
authors.lastname: Ten Kate
authors.forename: Matthias
authors.initials: M
authors.lastname: Rath
authors.forename: Ute
authors.initials: U
authors.lastname: Felbor
authors.forename: Suzanna M G
authors.initials: SM
authors.lastname: Frints
mesh_terms: D002648:Child; D002650:Child Abuse, Sexual / Q000175:diagnosis*; D003241:Consanguinity; D005220:Fathers; D005260:Female; D056426:Genetic Loci; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D006849:Hydrocephalus / Q000235:genetics* / Q000473:pathology; D009679:Nuclear Family; D011336:Probability