title: Positive association of adiponectin with soluble thrombomodulin, von Willebrand factor and soluble VCAM-1 in dyslipidemic subjects.
abstract: OBJECTIVE
  Both decreased and increased risk of cardiovascular events/mortality have been reported with high adiponectin levels. Only a few studies have reported an association of adiponectin with markers of hemostasis/endothelial dysfunction which might explain the reported discrepancies.
  
  
  METHODS
  We evaluated the association of total adiponectin with von Willebrand factor (vWF), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA), soluble thrombomodulin (sTM), adhesion molecules sICAM-1 and sVCAM-1, lipids and markers of insulin resistance (IR) in 308 asymptomatic dyslipidemic subjects and healthy controls. Subjects were divided into 4 dyslipidemic phenotypes (DLP): DLP1 (TG < 1.5 mmol/L + ApoB < 1.2 g/L), DLP2 (TG ≥ 1.5 + ApoB < 1.2), DLP3 (TG < 1.5 + ApoB ≥ 1.2) and DLP4 (TG ≥ 1.5 + ApoB ≥ 1.2). The results were evaluated also according to the presence (+) and absence (-) of metabolic syndrome (MS).
  
  
  RESULTS
  In hyperlipidemic subjects (DLP2-4), PAI-1, t-PA and sICAM-1 correlated with markers of IR but only t-PA correlated inversely with adiponectin. In contrast positive association of adiponectin with vWF, sTM and sVCAM-1 was found but none of these parameters correlated with markers of insulin resistance. In multiple regression analysis, adiponectin remained independently associated with vWF [in DLP3, DLP4, DLP2-4, MS(-)], with sTM [in DLP2, DLP4, DLP2-4, MS(+)] and with sVCAM-1 [in DLP2, DLP3, DLP4, DLP2-4, MS(+)]. In healthy controls (DLP1), no association between adiponectin and markers of hemostasis/endothelial dysfunction was found.
  
  
  CONCLUSIONS
  The independent positive association of adiponectin with vWF, sTM and sVCAM-1 deserves further evaluation in connection with the risk of atherothrombotic cardiovascular events.
authors.affiliation: 3rd Department of Internal Medicine, Faculty of Medicine and Dentistry UP Olomouc and University Hospital Olomouc, Czech Republic. helena.vaverkova@fnol.cz
authors.forename: Helena
authors.initials: H
authors.lastname: Vaverkova
authors.forename: David
authors.initials: D
authors.lastname: Karasek
authors.forename: Dalibor
authors.initials: D
authors.lastname: Novotny
authors.forename: Dagmar
authors.initials: D
authors.lastname: Kovarova
authors.forename: Milan
authors.initials: M
authors.lastname: Halenka
authors.forename: Ludek
authors.initials: L
authors.lastname: Slavik
authors.forename: Jiri
authors.initials: J
authors.lastname: Frohlich
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001055:Apolipoproteins B / Q000097:blood; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D019743:Chemokines, CXC; D050171:Dyslipidemias / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D018180:Thrombomodulin / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D052242:Adiponectin; D001055:Apolipoproteins B; D015415:Biomarkers; C508524:CXCL17 protein, human; D018925:Chemokines; D019743:Chemokines, CXC; C546931:THBD protein, human; D018180:Thrombomodulin; D014841:von Willebrand Factor; D018799:Intercellular Adhesion Molecule-1