title: Ceftobiprole - a case study.
abstract: Ceftobiprole medocaril is a cephalosporin prodrug that is under investigation for treatment of complicated skin and skin-structure infections (cSSSIs) due to methicillin-resistant Staphylococcus aureus (MRSA) and hospital-acquired pneumonia (HAP), including ventilator-associated pneumonia due to suspected or proven MRSA. Ceftobiprole was designed to bind the penicillin-resistant targets in Gram-positive bacteria, resulting in potent bactericidal activity against methicillin-resistant MRSA and penicillin-resistant Streptococcus pneumoniae (PRSP). In microbiological studies, ceftobiprole has demonstrated a broad-spectrum profile, with activity against many Gram-positive bacteria and a variety of important pathogenic Gram-negative bacteria. Ceftobiprole medocaril is being studied in Phase III clinical trials for cSSSI, HAP and hospitalised community-acquired pneumonia (hCAP). Top-line Phase III results in the first cSSSI study (STRAUSS 1) showed a high cure rate and good tolerability. The second cSSSI trial (STRAUSS 2) is targeting infections caused by Gram-positive and Gram-negative bacteria, and includes patients with diabetic foot infections. Ceftobiprole is expected to combine the well-established advantages of the cephalosporin antibiotic class with an enhanced spectrum of action, including against resistant Gram-positive bacteria.
authors.affiliation: Head of Biology, Basilea Pharmaceutica Ltd, Grenzacherstrasse 487, PO Box, CH-4005 Basel, Switzerland. malcolm.page@basilea.com.
authors.forename: Malcolm Gp
authors.initials: MG
authors.lastname: Page