title: Bromotyrosine alkaloids from the Australian marine sponge Pseudoceratina verrucosa.
abstract: Two new bromotyrosine alkaloids, pseudoceralidinone A (1) and aplysamine 7 (2), along with three known compounds were isolated from the Australian sponge Pseudoceratina verrucosa. Their structures were characterized by NMR and MS data and the synthetic route. Their cytotoxicity was evaluated against cancer cell lines (HeLa and PC3) and a noncancer cell line (NFF).
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
authors.forename: Trong D
authors.initials: TD
authors.lastname: Tran
authors.forename: Ngoc B
authors.initials: NB
authors.lastname: Pham
authors.forename: Gregory
authors.initials: G
authors.lastname: Fechner
authors.forename: John N A
authors.initials: JN
authors.lastname: Hooper
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001315:Australia; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010080:Oxazoles; D011161:Porifera / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014443:Tyrosine / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000470:Alkaloids; D006842:Hydrocarbons, Brominated; D010080:Oxazoles; D013844:Thiazoles; C582581:aplysamine 7; C475724:bromotyrosine; C582582:pseudoceralidinone A; D014443:Tyrosine