title: In vitro three-dimensional tumor microenvironment models for anticancer drug discovery.
abstract: Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.
authors.affiliation: The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA +1 215 898 0002 ; ksmalley@wistar.org.
authors.forename: Keiran Sm
authors.initials: KS
authors.lastname: Smalley
authors.forename: Mercedes
authors.initials: M
authors.lastname: Lioni
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Noma
authors.forename: Nikolas K
authors.initials: NK
authors.lastname: Haass
authors.forename: Meenhard
authors.initials: M
authors.lastname: Herlyn