title: Extraction of the volatile oil from Carum carvi of Tunisia and Lithuania by supercritical carbon dioxide: chemical composition and antiulcerogenic activity.
abstract: This study investigates whether the essential oil prepared from Carum carvi seeds exhibits antiulcerogenic activity. Its volatile oil was obtained by supercritical fluid extraction (SFE) and by hydrodistillation. The essential oils were analysed by GC-MS to monitor their composition. The chemical analysis revealed that the essential oils extracted under SFE conditions had high carvone and limonene contents. The antiulcerogenic activity was evaluated by the HCl/ethanol method, which causes injury to the gastric mucosa. Three treated groups received the essential oil (100-300 mg/kg). The reference group received omeprazole (30 mg/kg) and the control group received NaCl. After 30 min, all groups were treated with HCl/EtOH for gastric ulcer induction. The results show C. carvi essential oil enhanced a significant inhibition of 47%, 81% and 88%, respectively, for three doses of essential oil used, which was similar to that induced by omeprazole (95%) (p < 0.005).
authors.affiliation: a Laboratory of Pharmacology, Faculty of Medicine, University of Monastir , 5019 , Monastir , Tunisia.
authors.forename: Sameh
authors.initials: S
authors.lastname: Baananou
authors.forename: Edita
authors.initials: E
authors.lastname: Bagdonaite
authors.forename: Bruno
authors.initials: B
authors.lastname: Marongiu
authors.forename: Alessandra
authors.initials: A
authors.lastname: Piras
authors.forename: Silvia
authors.initials: S
authors.lastname: Porcedda
authors.forename: Danilo
authors.initials: D
authors.lastname: Falconieri
authors.forename: Naceur
authors.initials: N
authors.lastname: Boughattas
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D019661:Apiaceae / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D008297:Male; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D009853:Omeprazole; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy*
chemical_list: D000897:Anti-Ulcer Agents; D009822:Oils, Volatile; D002245:Carbon Dioxide; D009853:Omeprazole