title: Aggressive silent GH pituitary tumor resistant to multiple treatments, including temozolomide.
abstract: Temozolomide (TMZ) has been proposed as a therapeutic option in aggressive pituitary tumors. Among the published cases, GH expressing tumors were rare. We describe a patient with initially benign silent GH adenoma that transformed into an aggressive GH secreting tumor resistant to usual therapy. MGMT expression was high and the MGMT promoter was unmethylated. Before this aggressive course, patient received three cycles of TMZ; no response was observed. Four cases of GH aggressive tumor treated by TMZ have been reported. Response to TMZ was observed in one of these four patients. Predictive factors of failure of TMZ remain unclear.
authors.affiliation: Department Endocrinologie, CHU Clermont-Ferrand, Clermont-Ferrand, France. mbatisse@chu-clermontferrand.fr
authors.forename: Marie
authors.initials: M
authors.lastname: Batisse
authors.forename: Gérald
authors.initials: G
authors.lastname: Raverot
authors.forename: Salwan
authors.initials: S
authors.lastname: Maqdasy
authors.forename: Xavier
authors.initials: X
authors.lastname: Durando
authors.forename: Nathalie
authors.initials: N
authors.lastname: Sturm
authors.forename: Pierre-François
authors.initials: PF
authors.lastname: Montoriol
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Kemeny
authors.forename: Jean
authors.initials: J
authors.lastname: Chazal
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Trouillas
authors.forename: Igor
authors.initials: I
authors.lastname: Tauveron
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D015254:DNA Modification Methylases / Q000032:analysis / Q000235:genetics; D045643:DNA Repair Enzymes / Q000032:analysis / Q000235:genetics; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000077204:Temozolomide; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D025521:Tumor Suppressor Proteins / Q000032:analysis / Q000235:genetics
chemical_list: D018906:Antineoplastic Agents, Alkylating; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D019382:Human Growth Hormone; D003606:Dacarbazine; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes; D000077204:Temozolomide