title: The FAT epidemic: a gene family frequently mutated across multiple human cancer types.
authors.forename: Luc G T
authors.initials: LG
authors.lastname: Morris
authors.forename: Deepa
authors.initials: D
authors.lastname: Ramaswami
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Chan
mesh_terms: D000818:Animals; D015820:Cadherins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D009154:Mutation; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction; D051820:TCF Transcription Factors / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism; D000099317:Hippo Kinases
chemical_list: D015820:Cadherins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; D051820:TCF Transcription Factors; D051176:beta Catenin; C502403:FAT1 protein, human; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases
keywords: FAT1; cancer; mutation; signaling; tumor; tumor suppressor; wnt