title: Influencing factors for late-onset preeclampsia.
abstract: OBJECTIVE
  Different etiologies for early- (<34.0 weeks) and late (≥34.0 weeks)-onset preeclampsia (EO-LO PE) are reported. The aim of our study is to identify influencing factors for the LO form.
  
  
  METHODS
  Retrospective study of 284 consecutive women diagnosed as preeclamptic at 22.4-41.5 weeks, from 3/2005 to 10/2011, evaluated in relation to EO versus LO PE.
  
  
  RESULTS
  LO PE was identified in 151 cases. Gestational Diabetes Mellitus (11% versus 4%, p = 0.04), body mass index (BMI) ≥35 kg/m(2) (9% versus 2%, p = 0.03), pathological weight gain for BMI class (30% versus 13%, p = 0.001), ≥5 (58% versus 23%, p < 0.001) and ≥7 kg/m(2) BMI increase (19% versus 9%, p = 0.04) were more common in LO than in EO PE. At Estimation Regression analysis weighted for Gestational Age (GA) at delivery BMI ≥35 and ≥5 kg/m(2) BMI increase resulted related to LO PE (OR = 3.76, CI(95%) = 1.97-17.04; OR = 4.28, CI(95%) = 2.44-7.54).
  
  
  CONCLUSIONS
  BMI ≥35 and ≥5 kg/m(2) increase appeared as influencing factors for LO PE, thus supporting the role of systemic inflammation in its pathogenesis.
authors.affiliation: Department of Obstetrics and Gynecology, San Gerardo Hospital, University of Milan-Bicocca, Monza, Italy. sara.ornaghi@virgilio.it
authors.forename: Sara
authors.initials: S
authors.lastname: Ornaghi
authors.forename: Anastasia
authors.initials: A
authors.lastname: Tyurmorezova
authors.forename: Paola
authors.initials: P
authors.lastname: Algeri
authors.forename: Valentina
authors.initials: V
authors.lastname: Giardini
authors.forename: Patriza
authors.initials: P
authors.lastname: Ceruti
authors.forename: Emanuela
authors.initials: E
authors.lastname: Vertemati
authors.forename: Patrizia
authors.initials: P
authors.lastname: Vergani
mesh_terms: D000328:Adult; D017668:Age of Onset; D001724:Birth Weight / Q000502:physiology; D015992:Body Mass Index; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D009017:Morbidity; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors