title: [Research progress of mesenchymal stem cell-derived microvesicle].
abstract: Mesenchymal stem cell-derived microvesicle (MSC-MV) is a membrane secretory system which includes microparticle and exosome, and MSC-MV is released by MSC in resting or activated state. MSC-MV selectively package the biological active substances such as lipids, proteins, mRNA and miRNA but not loads them randomly. It has definitive effect of reducing tissue injury, promoting morphological and functional recovery of the injured tissue, and this effect is probably mediated by miRNA. What is more, the MSC-MV may also possess the biological function of immunological regulation, modulation of cell growth and differentiation. The generation, constitution, and function of MSC-MV are reviewed in this article.
authors.affiliation: Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Wang
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Zhu
authors.forename: Ping
authors.initials: P
authors.lastname: Zou
mesh_terms: D000818:Animals; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism
chemical_list: D035683:MicroRNAs