title: Metabolic and cardiovascular effects of beta cell replacement in type 1 diabetes.
abstract: Type 1 diabetes is associated with high morbidity and mortality, mostly due to the acute and chronic complications of the disease. Restoration of the lost beta cell mass by pancreas transplantation is the treatment of choice in selected type 1 diabetic patients. Growing data show that successful pancreas transplantation normalizes the metabolic alterations of diabetes, and can slow the progression, stabilize, and even favor the regression of secondary complications of the disease, including those at the cardiovascular level.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Pisa, Cisanello AOUP University Hospital, Pisa, Italy. piero.marchetti@med.unipi.it
authors.forename: Piero
authors.initials: P
authors.lastname: Marchetti
authors.forename: Margherita
authors.initials: M
authors.lastname: Occhipinti
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Rondinini
authors.forename: Rita
authors.initials: R
authors.lastname: Mariotti
authors.forename: Gabriella
authors.initials: G
authors.lastname: Amorese
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Barsotti
authors.forename: Fabio
authors.initials: F
authors.lastname: Vistoli
authors.forename: Ugo
authors.initials: U
authors.lastname: Boggi
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology*; D008055:Lipids / Q000097:blood; D016035:Pancreas Transplantation
chemical_list: D008055:Lipids