title: Prognostic and predictive biomarkers in gastroenteropancreatic neuroendocrine tumors.
abstract: Neuroendocrine tumors (NET) are a diverse group of tumors that derive from epithelial cells with neuroendocrine differentiation. Gastroenteropancreatic NETs are a subset of NET that arise from the gastrointestinal tract. The natural history and prognosis varies widely between different gastroenteropancreatic NETs, highlighting the importance of identifying accurate prognostic and predictive biomarkers. At the 2013 ASCO Gastrointestinal Cancers Symposium, De Braud et al. (Abstract #186) and Bellister et al. (Abstract #163) present data on two new possible biomarkers.
authors.affiliation: Tufts University School of Medicine, Boston, MA, USA. rstevenson@tuftsmedicalcenter.org
authors.forename: Ryan
authors.initials: R
authors.lastname: Stevenson
authors.forename: Steven K
authors.initials: SK
authors.lastname: Libutti
authors.forename: Muhammad Wasif
authors.initials: MW
authors.lastname: Saif
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D054316:Biomarkers, Pharmacological / Q000097:blood / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000068338:Everolimus; D005770:Gastrointestinal Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018358:Neuroendocrine Tumors / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011379:Prognosis; D020123:Sirolimus / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D054316:Biomarkers, Pharmacological; D014408:Biomarkers, Tumor; D000068338:Everolimus; C541572:PHLPP2 protein, human; D010749:Phosphoprotein Phosphatases; D020123:Sirolimus