title: Caspase-11: the noncanonical guardian of cytosolic sanctity.
abstract: Caspase-11 controls a noncanonical inflammasome that responds to Gram-negative bacteria and certain pore-forming toxins. Aachoui et al. (2013) and Case et al. (2013) identify a role for caspase-11 in rapid responses to bacterial pathogens that access the cytosol via vacuolar membrane disruption or the activity of specialized secretion systems.
authors.affiliation: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. sunshin@mail.med.upenn.edu
authors.forename: Sunny
authors.initials: S
authors.lastname: Shin
authors.forename: Igor E
authors.initials: IE
authors.lastname: Brodsky