title: [Urachal cancers].
abstract: Urachal cancer is a rare pathology (less than 1% among all bladder tumors) with a poor prognosis for all stages, because of clinical delay leading to a late diagnosis, difficult differential diagnosis with bladder cancer, and no consensus for the treatment, mostly about the chemotherapy for advanced stages, because there are no data from prospective studies. A surgical treatment can be performed for the localized stages, but there are no real guidelines for local relapses and metastatic progression treatment. Those cancers are not radio- or chemosensitive; nevertheless data from fundamental research are missing. As this pathology is really uncommon, there are no clinical studies with targeted therapies. The purpose of this review is to introduce the most important clinical and paraclinical features of those cancers, and the usual treatment performed.
authors.affiliation: Centre Oscar-Lambret, département de cancérologie digestive et urologique, 3, rue Frédérique-Combemale, 59020 Lille cedex, France. peugniezcharlotte@gmail.com
authors.forename: Charlotte
authors.initials: C
authors.lastname: Peugniez
authors.forename: Tarek
authors.initials: T
authors.lastname: Ghoneim
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
authors.forename: Eric
authors.initials: E
authors.lastname: Amela
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Fantoni
authors.forename: Stéphane
authors.initials: S
authors.lastname: Culine
authors.forename: Arnauld
authors.initials: A
authors.lastname: Villers
authors.forename: Antoine
authors.initials: A
authors.lastname: Adenis
mesh_terms: D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D035583:Rare Diseases / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy
keywords: chemotherapy; review; urachus