title: Experimental application of tissue adhesives in corneal traumas.
abstract: OBJECTIVE
  To evaluate intraoperative difficulties of the use of glues for corneal trauma.
  
  
  METHODS
  Partial or full-thickness perpendicular corneal incisions (3-4 mm straight cuts) near the limbus (perpendicular or parallel to it) were made in 8 albino rabbits and were then sealed with fibrin or cyanoacrylate glue. Follow-up examinations were performed under the surgical microscope. Tissue specimens were also taken for light microscopic evaluation.
  
  
  RESULTS
  The cyanoacrylate glue polymerized almost immediately after application on the tissue, limiting the ability of the surgeon to oppose the corneal incisions appropriately. The fibrin glue polymerized more gradually, giving enough time for manipulations to reconstruct the wound properly and for removal of excessive glue, especially when the 2 components were applied separately. Excessive glue and crust formation on the eye surface induced irritation.
  
  
  CONCLUSIONS
  Fibrin glue for the reconstruction of corneal wounds was easier to use than cyanoacrylate glue and caused less glue crust formation on the corneal surface. The speed of polymerization is an important factor. Excessive glue on the cornea was irritating.
authors.affiliation: Laboratory of Experimental Ophthalmology, Aristotle University, Thessaloniki, Greece. domnikipapadopoulou@yahoo.com
authors.forename: Domniki N
authors.initials: DN
authors.lastname: Papadopoulou
authors.forename: Antonia
authors.initials: A
authors.lastname: Sionga
authors.forename: Georgia
authors.initials: G
authors.lastname: Karayannopoulou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Natsis
authors.forename: Anastasia
authors.initials: A
authors.lastname: Komnenou
authors.forename: Georgios
authors.initials: G
authors.lastname: Mangioris
authors.forename: Antonios
authors.initials: A
authors.lastname: Kalpatsanidis
authors.forename: Anastasios
authors.initials: A
authors.lastname: Manthos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Georgiadis
authors.forename: Vasileios
authors.initials: V
authors.lastname: Karampatakis
mesh_terms: D000818:Animals; D003315:Cornea / Q000601:surgery; D065306:Corneal Injuries; D003487:Cyanoacrylates / Q000627:therapeutic use*; D004195:Disease Models, Animal; D015807:Eye Injuries, Penetrating / Q000601:surgery*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D011817:Rabbits
chemical_list: D003487:Cyanoacrylates; D015718:Fibrin Tissue Adhesive