title: Can maternal serum placental growth factor estimation in early second trimester predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction? A prospective cohort study.
abstract: OBJECTIVE
  To determine whether maternal serum placental growth factor (PlGF) estimation in early second trimester (20-22 weeks of gestation) can predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction (IUGR).
  
  
  METHODS
  A prospective cohort study was conducted on 722 women with singleton pregnancies, screened from the antenatal clinic, and serum PlGF levels were estimated at 20-22 weeks of gestation. A cut-off value of <155 pg/mL for serum PlGF was determined by receiver operating characteristic (ROC) curve analysis for identifying pregnant women at risk of developing early onset preeclampsia and/or early onset IUGR. Preeclampsia and IUGR were classified as early onset when diagnosed by 32 weeks of gestation. Univariate logistic regression analysis was used to analyze the association between serum PlGF level <155 pg/mL and the two outcome measures (i.e. early onset preeclampsia and early onset IUGR) and odds ratio (OR) was computed. P-value < 0.05 was considered statistically significant.
  
  
  RESULTS
  Maternal serum PlGF level <155 pg/mL at 20-22 weeks of gestation had a strong association with early onset preeclampsia (OR 8.35; 95% CI 1.79-18.94; P = 0.007) and with early onset IUGR (OR 10.73; 95% CI 4.08-20.23; P = 0.000). The sensitivity of serum PlGF < 155 pg/mL for predicting early onset preeclampsia and early onset IUGR were 82 and 84, respectively.
  
  
  CONCLUSIONS
  Maternal serum PlGF level estimation in early second trimester (20-22 weeks of gestation) may be useful in predicting the occurrence of early onset preeclampsia and/or early onset IUGR.
authors.affiliation: Department of Anatomy, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India. drsanjib79@gmail.com
authors.forename: Sanjib Kumar
authors.initials: SK
authors.lastname: Ghosh
authors.forename: Shashi
authors.initials: S
authors.lastname: Raheja
authors.forename: Anita
authors.initials: A
authors.lastname: Tuli
authors.forename: Chitra
authors.initials: C
authors.lastname: Raghunandan
authors.forename: Sneh
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D000328:Adult; D015331:Cohort Studies; D042241:Early Diagnosis; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor