title: Gold(I)-catalyzed macrocyclization of 1,n-enynes.
abstract: The gold(I)-catalyzed [2 + 2] cycloaddition of large 1,n-enynes (n = 10-16) provides access to 9- to 15-membered ring macrocycles incorporating a cyclobutene moiety. The reaction requires the use of a gold(I) catalyst bearing a sterically hindered biphenylphosphine ligand.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Carla
authors.initials: C
authors.lastname: Obradors
authors.forename: David
authors.initials: D
authors.lastname: Leboeuf
authors.forename: Juhanes
authors.initials: J
authors.lastname: Aydin
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Echavarren
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D008024:Ligands; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D008024:Ligands; D047028:Macrocyclic Compounds; D006046:Gold