title: [Sumoylation and its role in hematological disease].
abstract: Small ubiquitin-related modifier (SUMO) can be covalently attached to target proteins and thereby plays a crucial role in regulating the normal functions of cells, such as protein-protein interaction, subcellular localization, DNA repair, cell cycle and transcription factor regulation. Several lines have implicated that sumoylation is important in disease occurrence and development. This brief review will focus on some recent findings about the roles of sumoylation in the etiology and treatment of hematological malignancies.
authors.affiliation: Department of Hematology, The Second Military Medical University, Shanghai, China.
authors.forename: He-Jing
authors.initials: HJ
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Hou
mesh_terms: D000818:Animals; D006402:Hematologic Diseases / Q000473:pathology / Q000628:therapy; D006801:Humans; D058207:Sumoylation