title: Palladium-catalyzed insertion of N-tosylhydrazones for the synthesis of isoindolines.
abstract: Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with α,β-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration of a wide range of functional groups, (2) easy to handle and with mild conditions, (3) enriches the isoindoline family, (4) two new bonds form in one step.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
authors.forename: Ping-Xin
authors.initials: PX
authors.lastname: Zhou
authors.forename: Jian-Yi
authors.initials: JY
authors.lastname: Luo
authors.forename: Lian-Biao
authors.initials: LB
authors.lastname: Zhao
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: Ye
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D006835:Hydrazones / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000814:Aniline Compounds; D006835:Hydrazones; D007211:Indoles; D010165:Palladium; C057812:indoline; C023650:aniline