title: Effect of amtizol on resistance of SHR mice to acute hypoxia with hypercapnia under conditions of isolated functioning of one cerebral hemisphere.
abstract: Antihypoxant amtizol (25 mg/kg) prolonged the lifespan of intact SHR mice by 46.2% under conditions of isolated functioning of one cerebral hemisphere. The effect of amtizol on sham-operated animals was less pronounced: the lifespan of mice was prolonged by just 28.1%. Injection of amtizol to mice with active right hemisphere significantly prolonged the lifespan of experimental animals (by 64.8%). The drug was ineffective under conditions of active left hemisphere: the result coincided with the lifespan of similar mice without the drug injection. Hence, antihypoxic effect of amtizol was largely determined by its effect on the right, but not the left cerebral hemisphere.
authors.affiliation: Department of Pharmacology, S. M. Kirov Military Medical Academy, St. Petersburg, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Marysheva
authors.forename: V V
authors.initials: VV
authors.lastname: Mikheev
authors.forename: P D
authors.initials: PD
authors.lastname: Shabanov
mesh_terms: D000818:Animals; D054022:Cerebrum / Q000502:physiology*; D006935:Hypercapnia / Q000188:drug therapy*; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D013830:Thiadiazoles / Q000627:therapeutic use*
chemical_list: D013830:Thiadiazoles; C044365:amtizol