title: The impact of computed tomography on early glottic cancer outcomes.
abstract: OBJECTIVE
  Aim of this study was to evaluate the impact of computed tomography (CT)-based simulation and planning on early glottic cancer outcomes and toxicity.
  
  
  METHODS
  This is a single-institution retrospective study of 253 patients with T1-2 glottic cancer who underwent radiation therapy (RT) from January 1998-2010. Group A (80%) underwent 2-dimensional RT (2DRT) and group B (20%) 3-dimensional RT (3DRT). 76% of patients in group A and 84% in group B had T1 cancer. The median dose and fraction size were 63 Gy and 2.25 Gy, respectively.
  
  
  RESULTS
  With a median follow-up of 83, 93, and 30 months for the whole cohort, group A and B, respectively, the loco-regional control (LRC) was 97.6%. The rate of LRC for T1 disease was 99.5% and for T2 disease 91%. According to the RT modality, rates of LRC were 99.4 and 100% in groups A and B for T1, and 89.8 and 100% for T2. Long-term toxicity was negligible in both groups. Kaplan-Meier Curve showed the 5-year cause-specific survival to be 100%. Chi-square and multivariate analysis tests showed a significant relationship between CT simulation (3DRT) and LRC (p < 0.0001).
  
  
  CONCLUSIONS
  CT-based simulation and planning provided better LRC and less acute side effects compared to 2DRT.
authors.affiliation: Beth Israel Medical Center, New York, NY, USA. Waleed246@gmail.com
authors.forename: Waleed F
authors.initials: WF
authors.lastname: Mourad
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Hu
authors.forename: Rania A
authors.initials: RA
authors.lastname: Shourbaji
authors.forename: Dan
authors.initials: D
authors.lastname: Ishihara
authors.forename: Wilson
authors.initials: W
authors.lastname: Lin
authors.forename: Mahesh
authors.initials: M
authors.lastname: Kumar
authors.forename: Dukagjin M
authors.initials: DM
authors.lastname: Blakaj
authors.forename: Louis B
authors.initials: LB
authors.lastname: Harrison
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000401:mortality / Q000532:radiotherapy*; D015897:Comorbidity; D005260:Female; D005931:Glottis / Q000000981:diagnostic imaging; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D011832:Radiation Injuries / Q000401:mortality*; D020266:Radiotherapy, Conformal / Q000401:mortality*; D061089:Radiotherapy, Image-Guided / Q000401:mortality / Q000706:statistics & numerical data; D018570:Risk Assessment; D016019:Survival Analysis; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000401:mortality / Q000706:statistics & numerical data*; D016896:Treatment Outcome