title: Targeting metabolism to induce cell death in cancer cells and cancer stem cells.
abstract: Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes.
authors.affiliation: Equipe Labellisée Ligue Contre le Cancer, Equipe 9 CRCNA, INSERM UMR 892, CNRS UMR 6299, 44007 Nantes, France ; Faculté de Médecine, Université de Nantes, 44007 Nantes, France ; Centre de Recherche en Cancérologie Nantes Angers, INSERM UMR 892, CNRS UMR 6299, Université de Nantes 8 Quai Moncousu BP 70721, 44007 Cedex 1 Nantes, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Pecqueur
authors.forename: Lisa
authors.initials: L
authors.lastname: Oliver
authors.forename: Kristell
authors.initials: K
authors.lastname: Oizel
authors.forename: Lisenn
authors.initials: L
authors.lastname: Lalier
authors.forename: François M
authors.initials: FM
authors.lastname: Vallette