title: DNA/RNA binding and anticancer/antimicrobial activities of polymer-copper(II) complexes.
abstract: Water soluble polymer-copper(II) complexes with various degrees of coordination in the polymer chain were synthesized and characterized by elemental analysis, IR, UV-visible and EPR spectra. The DNA/RNA binding behavior of these polymer-copper(II) complexes was examined by UV-visible absorption, emission and circular dichroism spectroscopic methods, and cyclic voltammetry techniques. The binding of the polymer-copper(II) complexes with DNA/RNA was mainly through intercalation but some amount of electrostatic interaction was also observed. This binding capacity increased with the degree of coordination of the complexes. The polymer-copper(II) complex having the highest degree of coordination was subjected to analysis of cytotoxic and antimicrobial properties. The cytotoxicity study indicated that the polymer-copper(II) complexes affected the viability of MCF-7 mammary carcinoma cells, and the cells responded to the treatment with mostly through apoptosis although a few cells succumbed to necrosis. The antimicrobial screening showed activity against some human pathogens.
authors.affiliation: School of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
authors.forename: Jagadeesan
authors.initials: J
authors.lastname: Lakshmipraba
authors.forename: Sankaralingam
authors.initials: S
authors.lastname: Arunachalam
authors.forename: Anvarbatcha
authors.initials: A
authors.lastname: Riyasdeen
authors.forename: Rajakumar
authors.initials: R
authors.lastname: Dhivya
authors.forename: Sivanandham
authors.initials: S
authors.lastname: Vignesh
authors.forename: Mohammad Abdulkader
authors.initials: MA
authors.lastname: Akbarsha
authors.forename: Rathinam Arthur
authors.initials: RA
authors.lastname: James
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D001940:Breast / Q000166:cytology / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D005260:Female; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000494:pharmacology; D009181:Mycoses / Q000188:drug therapy; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D007364:Intercalating Agents; D011108:Polymers; D012313:RNA; D003300:Copper; D004247:DNA