title: Efficacy of sertraline in a patient with Neuro-Beçhet's disease.
abstract: Behçet's disease (BD) is a heterogeneous multisystem inflammatory disorder of unknown etiology, of which the involvement of the central nervous system is a serious manifestation (Neuro-Behçet's syndrome, NBS). We report a 65-year-old patient who presented with a progressive cognitive impairment and behavioral disturbances (depression and apathy). He fulfilled the International Study Group criteria for BD. Treatment with sertraline was then commenced with an objective improvement of his cognitive and behavioral status. The current report describes a patient with an extensive history of NBS (almost 20 years) and a possible therapeutic option for behavioral impairment.
authors.affiliation: Memory Clinic, Department of Neurology and Psychiatry, la Sapienza University, viale dell'Università 30, Rome 00185, Italy. giuseppe.tosto@yahoo.it
authors.forename: G
authors.initials: G
authors.lastname: Tosto
authors.forename: F
authors.initials: F
authors.lastname: Letteri
authors.forename: M
authors.initials: M
authors.lastname: Canevelli
authors.forename: G
authors.initials: G
authors.lastname: Bruno
mesh_terms: D000368:Aged; D001528:Behcet Syndrome / Q000150:complications / Q000188:drug therapy*; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline