title: Biomarkers of renal toxicity caused by exposure to arsenic in drinking water.
abstract: This study is intended to explore effective and sensitive biomarkers for kidney damage after low level arsenic (As) exposure and to provide scientific evidence on cut-off values of arsenic concentrations in drinking water. The levels of α1-MG detected in urine samples were found to have statistically significant differences between high As group (As>0.05 mg/L) and a combination of low and medium As exposure groups (As<0.05 mg/L, p=0.018), as well as between the patient and high As groups (As in two group were both higher than 0.05 mg/L, p<0.001). After the logistic regression analysis the AUC values of α1-MG between two comparisons were 0.613 and 0.701, and p value was less than 0.05. The present data demonstrate the potential value of α1-MG excretion as a biomarker of renal toxicity, which could contribute to the enforcement of the maximum limit of 0.05 mg/L arsenic in drinking water for non-central water supply in rural areas.
authors.affiliation: Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Key Lab of Etiology and Epidemiology, Education Bureau of HeiLong Jiang Province & Ministry of Health (23618104), Harbin 150081, China.
authors.forename: Hongqi
authors.initials: H
authors.lastname: Feng
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Gao
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhao
authors.forename: Yudan
authors.initials: Y
authors.lastname: Wei
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.forename: Dianjun
authors.initials: D
authors.lastname: Sun
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000368:Aged; D000418:Albumins / Q000032:analysis; D000510:Alpha-Globulins / Q000652:urine; D001151:Arsenic / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D002681:China; D060766:Drinking Water / Q000009:adverse effects / Q000032:analysis; D004781:Environmental Exposure / Q000009:adverse effects; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D000418:Albumins; D000510:Alpha-Globulins; D015415:Biomarkers; D060766:Drinking Water; D014874:Water Pollutants, Chemical; C016001:alpha-1-microglobulin; D000118:Acetylglucosaminidase; D001151:Arsenic