title: Poly-L-lysine-modified reduced graphene oxide stabilizes the copper nanoparticles with higher water-solubility and long-term additively antibacterial activity.
abstract: In order to improve the water-solubility and long-term antibacterial activity of copper nanoparticles (CuNPs), a poly-L-lysine-modified reduced graphene oxide (PLL-rGO) was used as the carrier of CuNPs, and a poly-L-lysine/reduced graphene oxide/copper nanoparticles (PLL-rGO-CuNPs) hybrid was prepared by anchoring the CuNPs on the reduced graphene oxide surface. The novel PLL-rGO-CuNPs hybrid was characterized and the antibacterial activity of it on gram-negative Escherichia coli and Gram-positive Staphylococcus aureus was tested. Such a hybrid showed additively antibacterial activity, and the CuNPs on PLL-rGO were more stable than those on polyvinyl pyrrolidone, resulting in long-term additively antibacterial effect. Meanwhile, this hybrid showed excellent water-solubility, suggesting great potential application in microbial control.
authors.affiliation: Guangdong Institute of Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangzhou 510070, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ouyang
authors.forename: Xiang
authors.initials: X
authors.lastname: Cai
authors.forename: QingShan
authors.initials: Q
authors.lastname: Shi
authors.forename: Lili
authors.initials: L
authors.lastname: Liu
authors.forename: Dongliang
authors.initials: D
authors.lastname: Wan
authors.forename: Shaozao
authors.initials: S
authors.lastname: Tan
authors.forename: Yousheng
authors.initials: Y
authors.lastname: Ouyang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D010084:Oxidation-Reduction; D010087:Oxides / Q000494:pharmacology*; D056951:Photoelectron Spectroscopy; D011107:Polylysine / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000166:cytology / Q000187:drug effects; D013997:Time Factors; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D010087:Oxides; D014867:Water; D011107:Polylysine; D006108:Graphite; D003300:Copper