title: Contrast enhancement during hepatic computed tomography: effect of total body weight, height, body mass index, blood volume, lean body weight, and body surface area.
abstract: OBJECTIVE
  The objective of this study was to evaluate the effect of total body weight, height, body mass index, blood volume, lean body weight, and body surface area (BSA) on aortic and hepatic contrast enhancement during hepatic computed tomography (CT).
  
  
  METHODS
  We calculated the changes in the CT number per gram of iodine ((Δ Hounsfield units/g [ΔHU/g])) for the aorta and the liver during portal venous phase. We performed linear regression analyses between ΔHU/g and each of the body parameters.
  
  
  RESULTS
  ΔHU/g and BSA showed the strongest inverse correlation. The correlation coefficients for the aorta and liver were 0.70 and 0.68 for ΔHU/g and total body weight, 0.41 and 0.37 for height, 0.54 and 0.55 for body mass index, 0.68 and 0.59 for blood volume, 0.70 and 0.62 for lean body weight, and 0.71 and 0.68 for BSA, respectively (P < 0.001 for all).
  
  
  CONCLUSIONS
  Our study supports the use of a protocol with iodine dose adjusted for the patient BSA.
authors.affiliation: Diagnostic Radiology, Amakusa Medical Center, Kumamoto, Japan. masafkidoh@yahoo.co.jp
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kidoh
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakaura
authors.forename: Seitaro
authors.initials: S
authors.lastname: Oda
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Namimoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Awai
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yoshinaka
authors.forename: Kazunori
authors.initials: K
authors.lastname: Harada
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001018:Aortic Diseases / Q000000981:diagnostic imaging*; D001810:Blood Volume; D001827:Body Height; D015992:Body Mass Index; D001830:Body Surface Area; D001835:Body Weight; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016014:Linear Models; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D036542:Tomography, Spiral Computed / Q000379:methods*
chemical_list: D003287:Contrast Media