title: Acquired melanonychia in chilean patients with essential thrombocythemia treated with hydroxyurea: a report of 7 clinical cases and review of the literature.
abstract: Longitudinal melanonychia has been associated with a range of drugs, especially chemotherapeutic agents. We report 7 cases of melanonychia associated with the use of hydroxycarbamide for essential thrombocythemia. Of a patient population of 27, 7 (26%) developed melanonychia over a period of 2-7 years, and was not dose dependent. The high incidence of melanonychia in Chilean patients may be in part due to their Hispanic descent or to the high levels of UV radiation found in Santiago.
authors.affiliation: Hematology Department, Hospital de Carabineros, Simon Bolıvar 2200, Nunoa, 7770199 Santiago, Chile ; Faculty of Medicine, University Mayor, Renato Sanchez 4369, Las Condes, 27550224 Santiago, Chile.
authors.forename: Nigel P
authors.initials: NP
authors.lastname: Murray
authors.forename: Pablo
authors.initials: P
authors.lastname: Tapia
authors.forename: Jose
authors.initials: J
authors.lastname: Porcell
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Echavarria
authors.forename: Hernán
authors.initials: H
authors.lastname: Suazo