title: PedsQL eosinophilic esophagitis module: feasibility, reliability, and validity.
abstract: OBJECTIVE
  Eosinophilic esophagitis (EoE) is a chronic esophageal inflammatory condition with a paucity of information on health-related quality of life (HRQOL). The objective of the study was to report on the measurement properties of the PedsQL EoE Module.
  
  
  METHODS
  The PedsQL EoE Module was completed in a multisite study by 196 pediatric patients with EoE and 262 parents of patients with EoE.
  
  
  RESULTS
  The PedsQL EoE Module scales evidenced excellent feasibility (0.6%-3.1% missing), excellent group comparison reliability across total scale scores (patient α 0.93; parent proxy α 0.94), good reliability for the 7 individual scales (patient α 0.75-0.87; parent proxy α 0.81-0.92), excellent test-retest reliability (patient intraclass correlation coefficient 0.88; parent intraclass correlation coefficient 0.82), demonstrated no floor effects and low ceiling effects, and demonstrated a high percentage of scaling success for most scales. Intercorrelations with the PedsQL Generic Core Scales were in the medium (0.30) to large (0.50) range. PedsQL EoE Module scores were worse among patients with active histologic disease (≥ 5 eos/hpf) compared with those in remission (patient self-report: 63.3 vs 69.9 [P < 0.05]; parent proxy report: 65.1 vs 72.3 [P < 0.01]), and those treated with dietary restrictions compared with those with no restrictions (patient self-report: 61.6 vs 74.3 [P < 0.01]; parent proxy report: 65.5 vs 74.7 [P < 0.01]).
  
  
  CONCLUSIONS
  The results demonstrate excellent measurement properties of the PedsQL EoE Module. Patients with active histologic disease and those treated with dietary restrictions demonstrated worse PedsQL scores. The PedsQL EoE Module may be used in the evaluation of pediatric EoE disease-specific HRQOL in clinical research and practice.
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. jpfranciosi@yahoo.com
authors.forename: James P
authors.initials: JP
authors.lastname: Franciosi
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Hommel
authors.forename: Cristiane B
authors.initials: CB
authors.lastname: Bendo
authors.forename: Eileen C
authors.initials: EC
authors.lastname: King
authors.forename: Margaret H
authors.initials: MH
authors.lastname: Collins
authors.forename: Michael D
authors.initials: MD
authors.lastname: Eby
authors.forename: Keith
authors.initials: K
authors.lastname: Marsolo
authors.forename: J Pablo
authors.initials: JP
authors.lastname: Abonia
authors.forename: Karl F
authors.initials: KF
authors.lastname: von Tiehl
authors.forename: Philip E
authors.initials: PE
authors.lastname: Putnam
authors.forename: Alexandria J
authors.initials: AJ
authors.lastname: Greenler
authors.forename: Allison B
authors.initials: AB
authors.lastname: Greenberg
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Bryson
authors.forename: Carla M
authors.initials: CM
authors.lastname: Davis
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Olive
authors.forename: Sandeep K
authors.initials: SK
authors.lastname: Gupta
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Erwin
authors.forename: Mary D
authors.initials: MD
authors.lastname: Klinnert
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Spergel
authors.forename: Jolanda M
authors.initials: JM
authors.lastname: Denham
authors.forename: Glenn T
authors.initials: GT
authors.lastname: Furuta
authors.forename: Marc E
authors.initials: ME
authors.lastname: Rothenberg
authors.forename: James W
authors.initials: JW
authors.lastname: Varni
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D017281:Cost of Illness; D057765:Eosinophilic Esophagitis / Q000178:diet therapy / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D004947:Esophagus / Q000473:pathology; D005190:Family; D005240:Feasibility Studies; D005260:Female; D006305:Health Status Indicators; D006306:Health Surveys; D006801:Humans; D008297:Male; D011788:Quality of Life; D015203:Reproducibility of Results; D057566:Self Report; D012720:Severity of Illness Index; D014481:United States