title: Resting EEG discrimination of early stage Alzheimer's disease from normal aging using inter-channel coherence network graphs.
abstract: Amnestic mild cognitive impairment (MCI) is a degenerative neurological disorder at the early stage of Alzheimer's disease (AD). This work is a pilot study aimed at developing a simple scalp-EEG-based method for screening and monitoring MCI and AD. Specifically, the use of graphical analysis of inter-channel coherence of resting EEG for the detection of MCI and AD at early stages is explored. Resting EEG records from 48 age-matched subjects (mean age 75.7 years)--15 normal controls (NC), 16 with early-stage MCI, and 17 with early-stage AD--are examined. Network graphs are constructed using pairwise inter-channel coherence measures for delta-theta, alpha, beta, and gamma band frequencies. Network features are computed and used in a support vector machine model to discriminate among the three groups. Leave-one-out cross-validation discrimination accuracies of 93.6% for MCI vs. NC (p < 0.0003), 93.8% for AD vs. NC (p < 0.0003), and 97.0% for MCI vs. AD (p < 0.0003) are achieved. These results suggest the potential for graphical analysis of resting EEG inter-channel coherence as an efficacious method for noninvasive screening for MCI and early AD.
authors.affiliation: Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: McBride
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Zhao
authors.forename: Nancy
authors.initials: N
authors.lastname: Munro
authors.forename: Charles
authors.initials: C
authors.lastname: Smith
authors.forename: Gregory
authors.initials: G
authors.lastname: Jicha
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology* / Q000523:psychology; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000523:psychology; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests