title: Making a NeST for a persistent virus.
abstract: In a recent issue of Cell, Gomez et al. (2013) describe a long intergenic noncoding RNA, called NeST, that regulates the ability of mice to respond to viral and bacterial infections. NeST recruits histone H3 lysine 4 methyltransferases to the IFN-γ gene locus, enhancing IFN-γ expression in key T cell subsets.
authors.affiliation: Department of Molecular Genetics & Microbiology and Center for Virology, Duke University Medical Center, Durham, NC 27710, USA. bryan.cullen@duke.edu
authors.forename: Bryan R
authors.initials: BR
authors.lastname: Cullen