title: The role of Type I interferons in immunoregulation of breast cancer metastasis to the bone.
abstract: Breast cancer spread to distant sites is often incurable. Our recent findings demonstrate that Type I interferons secreted by tumor cells induce anti-metastatic immune responses that prevent breast cancer metastasis to the bone. This provides novel insights into the importance of the crosstalk between neoplastic and immune cells in the metastatic process.
authors.affiliation: Research Division; Peter MacCallum Cancer Centre; East Melbourne, Australia ; Sir Peter MacCallum Department of Oncology; The University of Melbourne; Parkville, Australia.
authors.forename: Clare Y
authors.initials: CY
authors.lastname: Slaney
authors.forename: Andreas
authors.initials: A
authors.lastname: Möller
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Hertzog
authors.forename: Belinda S
authors.initials: BS
authors.lastname: Parker
keywords: bone metastasis; breast cancer; interferon; tumor immune surveillance