title: Reusable electrochemical cell for rapid separation of [¹⁸F]fluoride from [¹⁸O]water for flow-through synthesis of ¹⁸F-labeled tracers.
abstract: A brass-platinum electrochemical micro-flow cell was developed to extract [(18)F]fluoride from an aqueous solution and release it into an organic-based solution, suitable for subsequent radio-synthesis, in a fast and reliable manner. This cell does not suffer electrode erosion and is thus reusable while operating faster by enabling increased voltages. By optimizing temperature, trapping and release potentials, flow rates, and electrode materials, an overall [(18)F]fluoride trapping and release efficiency of 84 ± 5% (n=7) was achieved. X-ray photoelectron spectroscopy (XPS) was used to analyze electrode surfaces of various metal-metal systems and the findings were correlated with the performance of the electrochemical cell. To demonstrate the reactivity of the released [(18)F]fluoride, the cell was coupled to a flow-through reactor and automated synthesis of [(18)F]FDG with a repeatable decay-corrected yield of 56 ± 4% (n=4) was completed in < 15 min. A multi-human dose of 5.92GBq [(18)F]FDG was also demonstrated.
authors.affiliation: Crump Institute for Molecular Imaging and Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, 570 Westwood Plaza, Los Angeles, CA 90095, USA.
authors.forename: Saman
authors.initials: S
authors.lastname: Sadeghi
authors.forename: Vincent
authors.initials: V
authors.lastname: Liang
authors.forename: Shilin
authors.initials: S
authors.lastname: Cheung
authors.forename: Suh
authors.initials: S
authors.lastname: Woo
authors.forename: Curtis
authors.initials: C
authors.lastname: Wu
authors.forename: Jimmy
authors.initials: J
authors.lastname: Ly
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Deng
authors.forename: Mark
authors.initials: M
authors.lastname: Eddings
authors.forename: R Michael
authors.initials: RM
authors.lastname: van Dam
mesh_terms: D004563:Electrochemistry; D004566:Electrodes; D004867:Equipment Design; D017743:Equipment Reuse; D005459:Fluorides; D005462:Fluorine Radioisotopes / Q000302:isolation & purification*; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis*; D010104:Oxygen Radioisotopes / Q000302:isolation & purification; D056951:Photoelectron Spectroscopy; D014867:Water / Q000737:chemistry
chemical_list: D005462:Fluorine Radioisotopes; D010104:Oxygen Radioisotopes; D014867:Water; D019788:Fluorodeoxyglucose F18; D005459:Fluorides