title: The effect of the excisional biopsy in the detection of the sentinel lymph node by lymphoscintigraphy and intraoperative gamma probe in breast cancer.
abstract: OBJECTIVE
  Sentinel lymph node (SLN) scintigraphy is used widespread in breast cancer, but the effect of the radionuclide agent, injection technique, the method of biopsy, tumor localization, breast size remain controversial. We examined the effects of the excisional biopsy in the rate of the SLN identification with lymphoscintigraphy (LS) and intraoperative gamma probe (IGP).
  
  
  METHODS
  One hundred patients (age range: 28-79 yr) with breast cancer were included in the study. They consisted of two groups: Group 1; there were 58 patients without excisional biopsy Group 2; there were 42 patients with excisional biopsy LS: 2 hours before the operation, 37 MBq/ ml Tc 99m colloidal rhenium sulphide was injected at the periaerolar region intradermally Anterior and lateral static images were acquired. IGP: The hot spot of greatest radioactivity were marked on the skin during the surgery with IGP and removed. Excised SLNs were examined with frozen section. After that histopathological and immunohistochemical examinations were performed.
  
  
  RESULTS
  SLNs were found in all patients in group 1 (100%), in 39 patients of group 2 (93%) with LS. SLNs were excised in 57 of the 58 patients of group 1 (98%), in 38 of the 42 patients of group 2 (90%) with IGF. Metastases were found in SLNs in 27 patients (28%). Axillary dissection was performed in these patients.
  
  
  CONCLUSIONS
  According to results of our study the excisional biopsy was not the only factor but also other factors such as breast mass, calcified or metastatic lymph node may be affected the success rate of the SLN.
  
  
  BACKGROUND
  None declared.
authors.affiliation: Ankara Numune Training and Research Hospital, Nuclear Medicine, Ankara, Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Arıcan
authors.forename: Irfan
authors.initials: I
authors.lastname: Peksoy
authors.forename: Seniha
authors.initials: S
authors.lastname: Naldöken
authors.forename: Betül
authors.initials: B
authors.lastname: Bozkurt
keywords: Breast cancer; intraoperative gamma probe; lymphoscintigraphy; sentinel lymph node