title: Lethal aorto-oesophageal fistula - characteristic features and aetiology.
abstract: Aorto-oesophageal fistula refers to a rarely encountered communication between the aorta and the oesophagus that results in massive and lethal haemorrhage into the upper gastrointestinal tract. Although the time between the initial haemorrhage and the terminal event may be days, a clinical diagnosis may not be established by the time of autopsy. A fistulous tract develops between the aorta and the oesophagus most commonly due to expansion of a thoracic aortic aneurysm or from an ingested foreign body. Less common causes include infiltrating neoplasms, oesophageal ulceration, vascular rings and iatrogenic lesions. Three cases are presented to illustrate the features of such cases due to aortic dissection, bronchial carcinoma and tuberculosis. Cases should be suspected if there has been a history of midthoracic pain or dysphagia, a 'herald' haemorrhage and then massive fatal haematemesis with bright red blood. Careful dissection at autopsy is required to demonstrate the site of the fistulous tract.
authors.affiliation: Discipline of Anatomy and Pathology, Level 3 Medical School, North Building, The University of Adelaide, Frome Road, Adelaide 5005, SA, Australia. roger.byard@sa.gov.au
authors.forename: Roger W
authors.initials: RW
authors.lastname: Byard
mesh_terms: D000328:Adult; D000368:Aged; D017541:Aneurysm, False / Q000150:complications / Q000473:pathology; D001018:Aortic Diseases / Q000209:etiology / Q000473:pathology*; D004937:Esophageal Fistula / Q000209:etiology / Q000473:pathology*; D005260:Female; D005402:Fistula / Q000209:etiology / Q000473:pathology*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014388:Tuberculosis, Lymph Node / Q000150:complications / Q000473:pathology