title: Matrix metalloproteinase-1 gene polymorphisms and periodontitis susceptibility: a meta-analysis based on 11 case-control studies.
abstract: Matrix metalloproteinase-1 has been implicated in periodontal disease, but the association between the most-studied Matrix metalloproteinase-1 1G-to-2G polymorphism and the risk of periodontal disease were reported with inconclusive results. Therefore, the aim of this study was to investigate the association between the Matrix metalloproteinase-1 1G-to-2G polymorphism and periodontal disease. Electronic databases search yielded 11 studies with 1447 patients and 1710 control subjects evaluated the association of the polymorphisms of Matrix metalloproteinase-1 1G-to-2G and periodontitis risk were brought into this study. The association was evaluated by odds ratio (OR) and its 95% confidence interval (CI). The overall results showed that the variant genotypes were associated with a significantly increased risk of periodontitis (OR=1.45, 95% CI=1.02-1.26 for 2G/2G vs 1G/1G, and OR=2.27, 95% CI=1.22-4.23 for 2G/2G vs 1G/2G+1G/1G). In the stratified analyses, there was a significantly increased risk for the studies of periodontitis (OR=1.59, 95% CI=1.15-2.21 for 2G/2G vs 1G/1G; OR=3.48, 95% CI=1.39-8.71 for 2G/2G vs 1G/2G+1G/1G), which remained for the studies of Asian populations. And there was a significantly increased risk of severe periodontitis (OR=2.15, 95% CI=1.35-3.43 for 2G/2G vs 1G/1G; OR=2.86, 95% CI=1.31-2.64 for 2G/2G vs 1G/2G+1G/1G; OR=1.6, 95% CI=1.12-2.39 for 1G/2G+2G/2G vs 1G/1G; OR=1.61, 95% CI=1.28-2.03 for 2G allele vs 1G allele). The current study demonstrated that the Matrix metalloproteinase-1-1607 1G-to-2G polymorphism was associated with susceptibility to periodontitis, apparently, severe periodontitis.
authors.affiliation: Department of Endodontics, Stomatological Hospital, College of Medicine, Xi'an Jiaotong University, No. 98 Xiwu Road, Xincheng District, Xi'an, Shaanxi 710004, PR China. tiezhou@mail.xjtu.edu.cn
authors.forename: Tiezhou
authors.initials: T
authors.lastname: Hou
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zheng
authors.forename: Zhongqi
authors.initials: Z
authors.lastname: Liu
authors.forename: Cuiyan
authors.initials: C
authors.lastname: Wu
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Shixun
authors.initials: S
authors.lastname: Wu
authors.forename: Xiong
authors.initials: X
authors.lastname: Guo
mesh_terms: D016022:Case-Control Studies; D016001:Confidence Intervals; D020022:Genetic Predisposition to Disease; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D016017:Odds Ratio; D010518:Periodontitis / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D020781:Matrix Metalloproteinase 1