title: Changes in health-related quality of life and functioning ability in help-seeking adolescents and adolescents at heightened risk of developing psychosis during family- and community-oriented intervention model.
abstract: Abstract Objective. Early intervention has been shown to benefit people at-risk for psychosis, but knowledge about how early intervention benefits all help-seeking adolescents is lacking. The aim of the present study was to study change in health-related quality of life (QoL) and functioning ability in help-seeking adolescents who participate in a community- and family-oriented early intervention program. Methods. The data was collected in Finland by an early-intervention team. Ninety help-seeking adolescents between 12 and 21 years of age filled out a questionnaire on QoL (16D) and functioning ability (GAF), which was assessed by workers at the beginning and at the end of the intervention. A PROD screen was used to assess heightened risk of developing psychosis. Results. QoL and functioning ability showed significant differences (p < 0.001) between the beginning and the end of the intervention, as well in a subgroup of participants at heightened risk of developing psychosis (QoL, p = 0.008; GAF, p < 0.001: n = 35). 35.6% improved over the clinical cut-off point in functioning ability and 48.6% of the subjects at-risk. 53.3% reached clinically significant improvement in QoL and 54.2% of the subjects at heightened risk of developing psychosis. Conclusions. The results suggest that there is both statistically and clinically remarkable improvement in QoL and functioning ability after a need-adapted, family- and community-oriented intervention.
authors.affiliation: Helsinki University Central Hospital, Jorvi Hospital, Department of Psychiatry , Finland.
authors.forename: Niklas
authors.initials: N
authors.lastname: Granö
authors.forename: Marjaana
authors.initials: M
authors.lastname: Karjalainen
authors.forename: Virve
authors.initials: V
authors.lastname: Edlund
authors.forename: Erkki
authors.initials: E
authors.lastname: Saari
authors.forename: Arja
authors.initials: A
authors.lastname: Itkonen
authors.forename: Jukka
authors.initials: J
authors.lastname: Anto
authors.forename: Mikko
authors.initials: M
authors.lastname: Roine
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000293:Adolescent; D002648:Child; D003156:Community Mental Health Services; D004198:Disease Susceptibility / Q000523:psychology*; D042241:Early Diagnosis; D061345:Early Medical Intervention / Q000379:methods*; D005196:Family Therapy; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010342:Patient Acceptance of Health Care / Q000523:psychology* / Q000706:statistics & numerical data; D011618:Psychotic Disorders / Q000175:diagnosis / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012307:Risk Factors; D013315:Stress, Psychological / Q000523:psychology / Q000628:therapy; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult