title: Pd-catalyzed selective carbonylative and non-carbonylative couplings of propiolic acid: one-pot synthesis of diarylalkynones.
abstract: Diarylalkynones were synthesized from one-pot Pd-catalyzed carbonylative and noncarbonylative coupling reactions of propiolic acid with aryl iodides under a carbon monoxide atmosphere. Aryl iodide (2.0 equiv), propiolic acid (1.0 equiv), Pd(PPh3)2Cl2 (5 mol %), CuCl (10 mol %), Et3N (6.0 equiv), and CO (8 atm) were reacted under optimized conditions in CH3CN at 80 °C for 1 h. This process afforded good yields and functional group tolerance.
authors.affiliation: Department of Chemistry, Chonnam National University, Gwangju, 500-757, Republic of Korea.
authors.forename: Wonyoung
authors.initials: W
authors.lastname: Kim
authors.forename: Kyungho
authors.initials: K
authors.lastname: Park
authors.forename: Ahbyeol
authors.initials: A
authors.lastname: Park
authors.forename: Juseok
authors.initials: J
authors.lastname: Choe
authors.forename: Sunwoo
authors.initials: S
authors.lastname: Lee
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002248:Carbon Monoxide / Q000737:chemistry; D002384:Catalysis; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011422:Propionates / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006847:Hydrocarbons, Iodinated; D007659:Ketones; D011422:Propionates; D010165:Palladium; D002248:Carbon Monoxide; C011537:propiolic acid