title: The effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra-abdominal sepsis.
abstract: In the present study, the effects of dexmedetomidine on secondary lung and kidney injuries were studied in the rat model of intra-abdominal sepsis by immunohistological and biochemical examinations. We measured serum creatinine, kidney tissue malondialdehide and plasma neutrophil gelatinase-associated lipocalin levels. In order to evaluate tissue injury we determined kidney tissue mononuclear cell infiltration score, alveolar macrophage count, histological kidney and lung injury scores and kidney and lung tissue immunoreactivity scores. We demonstrated that dexmedetomidine attenuates sepsis-induced lung and kidney injuries and apoptosis in the rat model of sepsis. There is still need for comparative studies in order to determine the effects of dexmedetomidine on organ functions in early human sepsis.
authors.affiliation: Department of Anaesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, Inciralti, 35340 İzmir, Turkey. ugur.koca@deu.edu.tr
authors.forename: Uğur
authors.initials: U
authors.lastname: Koca
authors.forename: Çimen Gülben
authors.initials: ÇG
authors.lastname: Olguner
authors.forename: Bekir Uğur
authors.initials: BU
authors.lastname: Ergür
authors.forename: Emel
authors.initials: E
authors.lastname: Altekin
authors.forename: Aydın
authors.initials: A
authors.lastname: Taşdöğen
authors.forename: Seden
authors.initials: S
authors.lastname: Duru
authors.forename: Pelin
authors.initials: P
authors.lastname: Girgin
authors.forename: Kerim
authors.initials: K
authors.lastname: Gündüz
authors.forename: Serap
authors.initials: S
authors.lastname: Cilaker Mıcılı
authors.forename: Seda
authors.initials: S
authors.lastname: Güzeldağ
authors.forename: Muhammed
authors.initials: M
authors.lastname: Akkuş
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000473:pathology; D055371:Acute Lung Injury / Q000188:drug therapy* / Q000473:pathology; D000209:Acute-Phase Proteins; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D002432:Cecum / Q000293:injuries*; D002452:Cell Count; D003404:Creatinine / Q000097:blood; D053938:DNA Fragmentation; D020927:Dexmedetomidine / Q000494:pharmacology*; D004195:Disease Models, Animal; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood; D008168:Lung / Q000187:drug effects / Q000473:pathology; D016676:Macrophages, Alveolar / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000473:pathology*
chemical_list: D000209:Acute-Phase Proteins; C097278:Lcn2 protein, rat; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D008315:Malondialdehyde; D020927:Dexmedetomidine; D003404:Creatinine; C505410:Casp3 protein, rat; D053148:Caspase 3