title: Shell crosslinked knedel-like nanoparticles for delivery of cisplatin: effects of crosslinking.
abstract: Polymeric micelles and shell crosslinked knedel-like (SCK) nanoparticles were loaded with up to 48% (w/w) cisplatin. These spherical cisplatin-loaded nanoparticles displayed sustained platinum release over 5 days in PBS, enhanced stability over free cisplatin in aqueous milieu, and significant antitumor activity in vitro against two cancer cell lines.
authors.affiliation: Department of Chemistry, Laboratory for Synthetic - Biologic Interactions, Texas A&M University, P.O. Box 30012, 3255 TAMU, College Station, Texas 77842-3012, USA.
authors.forename: Fuwu
authors.initials: F
authors.lastname: Zhang
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Elsabahy
authors.forename: Shiyi
authors.initials: S
authors.lastname: Zhang
authors.forename: Lily Yun
authors.initials: LY
authors.lastname: Lin
authors.forename: Jiong
authors.initials: J
authors.lastname: Zou
authors.forename: Karen L
authors.initials: KL
authors.lastname: Wooley
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002478:Cells, Cultured; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D006801:Humans; D051379:Mice; D008823:Micelles; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D057145:Nanoshells / Q000737:chemistry; D010316:Particle Size
chemical_list: D000970:Antineoplastic Agents; D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D008823:Micelles; D002945:Cisplatin