title: Fluconazole-malonic acid (1/1).
abstract: Co-crystallizaton of the anti-fungal drug fluconazole [2-(2,4-difluoro-phen-yl)-1,3-bis-(1H-1,2,4-triazol-1-yl)propan-2-ol] with malonic acid in acetonitrile solution resulted in the formation of the title 1:1 co-crystal, C13H12F2N6O·C3H4O4. The geometry around the central fluconazole atom is distorted tetrahedral. The dihedral angles between the triazole rings and the fluorinated phenyl ring are 30.64 (7) and 61.91 (5)°. In the crystal, the basic packing motif may be envisioned as a cyclic aggregate formed of two fluconazole mol-ecules linked by two malonic acid mol-ecules through O-H⋯N and O-H⋯O hydrogen bonds. Such aggregates are further connected into (001) layers by further O-H⋯N hydrogen bonds. The structure also features weak non-classical C-H⋯O and C-H⋯N inter-actions.
authors.affiliation: Krka d.d., Šmarješka cesta 6, 8501 Novo mesto, Slovenia.
authors.forename: Jože
authors.initials: J
authors.lastname: Kastelic
authors.forename: Danijel
authors.initials: D
authors.lastname: Kikelj
authors.forename: Ivan
authors.initials: I
authors.lastname: Leban
authors.forename: Nina
authors.initials: N
authors.lastname: Lah