title: Synthesis and antimalarial bioassay of quinine - peptide conjugates.
abstract: Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100 nm, similar to quinine.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, 32611-7200, USA.
authors.forename: Siva S
authors.initials: SS
authors.lastname: Panda
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Ibrahim
authors.forename: Hasan
authors.initials: H
authors.lastname: Küçükbay
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Meyers
authors.forename: Francis M
authors.initials: FM
authors.lastname: Sverdrup
authors.forename: Said A
authors.initials: SA
authors.lastname: El-Feky
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D001681:Biological Assay; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010455:Peptides / Q000737:chemistry*; D011803:Quinine / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D010455:Peptides; D011803:Quinine
keywords: amino acid; chemical biology; drug design; peptide