title: Targeting apoptosis by the remodelling of calcium-transporting proteins in cancerogenesis.
abstract: Calcium is a universal messenger regulating many physiological functions, including the ability of the cell to undergo orderly self-destruction upon completion of its function, called apoptosis. In physiopathological conditions such as cancer, apoptotic processes become deregulated, leading to apoptosis-resistant phenotypes. Recently, perturbations of cellular calcium homeostasis have been described in apoptosis-resistant cell phenotypes. Thereby, new molecular actors have been identified, offering more accurate research possibilities in the field of apoptosis resistance and providing the bases for more rational approaches to cancer treatments. In this review, we focus on the calcium-transporting protein-dependent pathways involved in apoptosis, which are deregulated by cancer. We present the calcium-transporting proteins involved in the deregulation of apoptosis, and those chemotherapies that target actors in calcium-induced apoptosis.
authors.affiliation: Inserm, U-1003, Equipe labellisée par la Ligue Nationale contre le cancer. Laboratory of Excellence, Ion Channels Science and Therapeutics, Université des Sciences et Technologies de Lille (USTL), Villeneuve d'Ascq, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Dubois
authors.forename: Fabien
authors.initials: F
authors.lastname: Vanden Abeele
authors.forename: Natacha
authors.initials: N
authors.lastname: Prevarskaya
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D002352:Carrier Proteins; D002118:Calcium
keywords: apoptosis; calcium; cancer; chemotherapy; resistance