title: The effect of Helicobacter pylori on gastroesophageal reflux disease.
abstract: OBJECTIVE
  Helicobacter pylori infection represents one of the most common and medically prominent infections worldwide. Gastroesophageal reflux disease (GERD) has a multifactorial etiology. The nature of the relationship between Helicobacter pylori infection (HP) and reflux esophagitis is still not clear. This study is designed to find the influence of HP on GERD.
  
  
  METHODS
  The study was conducted retrospectively at Sakarya Newcity Hospital between January 2006 and January 2009. Data were collected on patient's age, sex, weight, the grade of GERD and the severity of HP.
  
  
  RESULTS
  There were 1,307 women and 1,135 men in this review with a mean age of 39,54 (range, 17 to 70) years. Helicobacter pylori positive (1 to 3 severity) was frequently seen in patients with GERD. A statistically significant relationship was found between HP positivity and the grade of GERD. The Helicobacter pylori infection (1 to 3 severity) was found in 1,437 (82.5%) of patients with GERD in our series.
  
  
  CONCLUSIONS
  Controversy still exists about the association between GERD and HP infection. Based on our findings, significant evidence suggests the potential role of HP infection in the development of GERD. Also, the current data provide sufficient evidence to define the relationship between GERD and HP infection.
authors.affiliation: Department of Surgery, New City State Hospital, Sakarya, Turkey. polat22@hotmail.com
authors.forename: Fatin R
authors.initials: FR
authors.lastname: Polat
authors.forename: Sabriye
authors.initials: S
authors.lastname: Polat
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D016145:Endoscopy, Digestive System; D004941:Esophagitis / Q000382:microbiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000382:microbiology