title: Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression.
abstract: Gastritis cystica profunda (GCP) is a rare condition caused by ectopic entrapment of gastric glands, probably secondary to the disruption of muscularis mucosae. GCP is often associated with gastric adenocarcinoma, and loss of the KCNE2 subunit from potassium channel complexes is considered a common primary target molecule leads to both GCP and malignancy. In this study, we, for the first time, analyzed the expression of KCNE2 in surgically excised tissue from human gastric cancer associated with GCP and confirmed that reduced KCNE2 expression correlates with disease formation.
authors.affiliation: Department of Molecular Pathology, Ehime University, Graduate School of Medicine, Ehime 791-0295, Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Kuwahara
authors.forename: Riko
authors.initials: R
authors.lastname: Kitazawa
authors.forename: Koto
authors.initials: K
authors.lastname: Fujiishi
authors.forename: Yusa
authors.initials: Y
authors.lastname: Nagai
authors.forename: Ryuma
authors.initials: R
authors.lastname: Haraguchi
authors.forename: Sohei
authors.initials: S
authors.lastname: Kitazawa
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D015536:Down-Regulation; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000737:chemistry / Q000473:pathology; D005756:Gastritis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D024642:Potassium Channels, Voltage-Gated / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; C489619:KCNE2 protein, human; D024642:Potassium Channels, Voltage-Gated
keywords: Gastritis cystica profunda; Immunohistochemistry; KCNE2