title: Norfriedelins A-C with acetylcholinesterase inhibitory activity from acerola tree (Malpighia emarginata).
abstract: Three novel norfriedelanes, A-C (1-3), were isolated from the branches and roots of Malpighia emarginata . Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an α-oxo-β-lactone group) and norfriedelin B (with a keto-lactone group) showed acetylcholinesterase inhibitory effects with the IC50 values of 10.3 and 28.7 μM, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China.
authors.forename: Jie-Qing
authors.initials: JQ
authors.lastname: Liu
authors.forename: Xing-Rong
authors.initials: XR
authors.lastname: Peng
authors.forename: Xu-Yang
authors.initials: XY
authors.lastname: Li
authors.forename: Ting-Zhao
authors.initials: TZ
authors.lastname: Li
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Jiang
authors.initials: J
authors.lastname: Han
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Qiu
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D020128:Inhibitory Concentration 50; D029581:Malpighiaceae / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D002800:Cholinesterase Inhibitors; D014315:Triterpenes; C583349:norfriedelin A; C583350:norfriedelin B; C583351:norfriedelin C