title: Brain MRI volumetry in a single patient with mild traumatic brain injury.
abstract: This letter to the editor describes the case of a 42 year old man with mild traumatic brain injury and multiple neuropsychiatric symptoms which persisted for a few years after the injury. Initial CT scans and MRI scans of the brain showed no signs of atrophy. Brain volume was measured using NeuroQuant®, an FDA-approved, commercially available software method. Volumetric cross-sectional (one point in time) analysis also showed no atrophy. However, volumetric longitudinal (two points in time) analysis showed progressive atrophy in several brain regions. This case illustrated in a single patient the principle discovered in multiple previous group studies, namely that the longitudinal design is more powerful than the cross-sectional design for finding atrophy in patients with traumatic brain injury.
authors.forename: David E
authors.initials: DE
authors.lastname: Ross
authors.forename: Cody
authors.initials: C
authors.lastname: Castelvecchi
authors.forename: Alfred L
authors.initials: AL
authors.lastname: Ochs
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D038223:Post-Concussion Syndrome / Q000473:pathology*; D014481:United States