title: Comparison of the inhibitory effect against copper ion-induced oxidation in rat plasma after oral administration of salvianolic acid B and its decocted solutions.
abstract: The effects of salvianolic acid B (Sal B) decoction on antioxidative activities were evaluated. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity, Fe(2+)-chelating activity, reducing power, and total phenolic content of the Sal B-decocted solutions did not change significantly after decoction in an aqueous solution. However, the formation of cholesteryl ester hydroperoxide (CE-OOH) in rat blood plasma containing the Sal B-decocted solutions was more effectively inhibited than that of plasma containing the Sal B solution, regardless of the decoction time. In addition, the accumulation of CE-OOH in rat plasma after oral administration of the Sal B-decocted solutions was more effectively suppressed than when the Sal B solution was administered, considering the lag time. It is likely that the decoction was partly responsible for the increased antioxidant activity in blood plasma. Therefore, the Sal B-decocted solution may contribute more to antioxidant defense in blood than a Sal B solution that is not decocted.
authors.affiliation: Department of Food Science and Technology, and Functional Food Research Center, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Hyoung Jae
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jeong-Yong
authors.initials: JY
authors.lastname: Cho
authors.forename: Jae-Hak
authors.initials: JH
authors.lastname: Moon
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001572:Benzofurans / Q000032:analysis / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D002614:Chelating Agents / Q000494:pharmacology; D002788:Cholesterol Esters / Q000097:blood*; D003300:Copper / Q000009:adverse effects*; D007477:Ions / Q000009:adverse effects; D008297:Male; D010084:Oxidation-Reduction; D010636:Phenols / Q000032:analysis / Q000494:pharmacology*; D010851:Picrates / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D028321:Plant Preparations; D051381:Rats; D017207:Rats, Sprague-Dawley; D027544:Salvia / Q000737:chemistry*; D053630:Depsides
chemical_list: D000975:Antioxidants; D001572:Benzofurans; D001713:Biphenyl Compounds; D002614:Chelating Agents; D002788:Cholesterol Esters; D003300:Copper; D007477:Ions; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D028321:Plant Preparations; C081459:cholesteryl ester hydroperoxide; C076944:salvianolic acid B; D053630:Depsides; C004931:1,1-diphenyl-2-picrylhydrazyl