title: Approach towards developing a novel procedure to selectively quantify topically applied substances in the hair follicles of the model tissue porcine ear skin.
abstract: Hair follicles represent reservoirs for localized drug therapy and transport pathways for systemic drug delivery. This study describes an approach towards developing a novel procedure for quantifying topically applied substances located in the hair follicles of porcine ear skin, a model for human in vivo skin, using a fluorescent dye. Approximately 5% of the topically applied dye was recovered from the hair follicles, which is in accordance with a previous study.
authors.forename: Fanny
authors.initials: F
authors.lastname: Knorr
authors.forename: Alexa
authors.initials: A
authors.lastname: Patzelt
authors.forename: Heike
authors.initials: H
authors.lastname: Richter
authors.forename: Sabine
authors.initials: S
authors.lastname: Schanzer
authors.forename: Wolfram
authors.initials: W
authors.lastname: Sterry
authors.forename: Juergen
authors.initials: J
authors.lastname: Lademann
mesh_terms: D000287:Administration, Topical; D000818:Animals; D016503:Drug Delivery Systems; D004423:Ear / Q000473:pathology; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D018859:Hair Follicle / Q000187:drug effects* / Q000473:pathology; D008856:Microscopy, Fluorescence; D023421:Models, Animal; D012235:Rhodamines / Q000493:pharmacokinetics; D012867:Skin / Q000187:drug effects; D012869:Skin Absorption; D013552:Swine
chemical_list: D005456:Fluorescent Dyes; D012235:Rhodamines; C027755:rhodamine isothiocyanate