title: Association between a MYH9 polymorphism (rs3752462) and renal function in the Spanish RENASTUR cohort.
abstract: The MYH9 gene encodes a protein that is expressed in the kidney glomerular podocytes. MYH9 single nucleotide polymorphisms (SNPs) have been linked to the risk for chronic kidney disease (CKD) and end stage renal disease. Our aim was to determine whether MYH9 SNPs were associated with renal disease in Spanish Caucasians. The RENASTUR cohort consisted of 592 Spanish Caucasians, aged 55-85 years. They were genotyped for SNPs rs3752462 and rs4821480, which tagged haplotype E. The main values between individuals with a glomerular filtration rate (eGFR) <60 and ≥ 60 ml/min/1.73 m(2) were statistically compared. The next variables were significantly associated with the eGFR in the univariate analysis: age, gender, type 2 diabetes, total cholesterol, total LDL-cholesterol, and the MYH9 rs3752462 (TC+TT genotypes; p=0.003). This SNP remained significantly associated with the eGFR in the multivariate analysis. In conclusion, SNP rs3752462 was an independent predictor of reduced eGFR in the Spanish RENASTUR population. The genotyping of this MYH9 SNP could help to identify individuals at risk of developing CKD.
authors.affiliation: Genética Molecular-Laboratorio Medicina, HUCA, Oviedo, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Tavira
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.forename: Juan
authors.initials: J
authors.lastname: Gómez
authors.forename: Salvador
authors.initials: S
authors.lastname: Tranche
authors.forename: Kevin
authors.initials: K
authors.lastname: Miguélez
authors.forename: Francisco
authors.initials: F
authors.lastname: Ortega
authors.forename: Beatriz
authors.initials: B
authors.lastname: Díez
authors.forename: Emilio
authors.initials: E
authors.lastname: Sánchez
authors.forename: Rafael
authors.initials: R
authors.lastname: Marín
authors.forename: Jorge
authors.initials: J
authors.lastname: Arenas
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D005919:Glomerular Filtration Rate; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020409:Molecular Motor Proteins / Q000235:genetics*; D015999:Multivariate Analysis; D018995:Myosin Heavy Chains / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology / Q000235:genetics*; D013030:Spain / Q000453:epidemiology; D044465:White People / Q000235:genetics
chemical_list: C103814:MYH9 protein, human; D020409:Molecular Motor Proteins; D018995:Myosin Heavy Chains