title: Direct syntheses of spiro- and fused-hydrofurans by a tunable tandem semipinacol rearrangement/oxa-Michael addition protocol.
abstract: A highly chemoselective one-pot reaction has been developed involving a tandem semipinacol rearrangement/oxa-Michael addition sequence in which the in situ generated ketol diene intermediate can be transformed specifically to either the spiro- or fused-dihydrofuran products (see scheme). This one-pot tandem reaction represents a general synthetic methodology for the syntheses of the two different kinds of furan derivatives.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Bao-Sheng
authors.initials: BS
authors.lastname: Li
authors.forename: Wen-Xing
authors.initials: WX
authors.lastname: Liu
authors.forename: Qing-Wei
authors.initials: QW
authors.lastname: Zhang
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wang
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Zhang
authors.forename: Shu-Yu
authors.initials: SY
authors.lastname: Zhang
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Tu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Cao
mesh_terms: D053138:Cyclohexenes / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D053138:Cyclohexenes; D005663:Furans; D013141:Spiro Compounds; C519041:semipinacol