title: Synthesis of pyrazolo[1,5-c]quinazoline derivatives through copper-catalyzed tandem reaction of 5-(2-bromoaryl)-1H-pyrazoles with carbonyl compounds and aqueous ammonia.
abstract: A practical and efficient synthesis of pyrazolo[1,5-c]quinazolines and 5,6-dihydropyrazolo[1,5-c]quinazolines, including several spiro compounds, through copper-catalyzed tandem reaction of 5-(2-bromoaryl)-1H-pyrazoles with carbonyl compounds and aqueous ammonia under air has been developed. Compared with literature methods toward pyrazolo[1,5-c]quinazoline derivatives, the synthetic method reported in this paper has the advantages of readily available and inexpensive starting materials and reagents, broad scope of substrates, and mild reaction conditions.
authors.affiliation: School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, People's Republic of China. shguo@htu.cn
authors.forename: Shenghai
authors.initials: S
authors.lastname: Guo
authors.forename: Jiliang
authors.initials: J
authors.lastname: Wang
authors.forename: Xuesen
authors.initials: X
authors.lastname: Fan
authors.forename: Xinying
authors.initials: X
authors.lastname: Zhang
authors.forename: Dongqiang
authors.initials: D
authors.lastname: Guo
mesh_terms: D000641:Ammonia / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D007659:Ketones; D011720:Pyrazoles; D011799:Quinazolines; C583525:pyrazolo(1,5-c)quinazoline; D014867:Water; D000641:Ammonia; D003300:Copper