title: Evidence-based review for patients undergoing elective hip and knee replacement.
abstract: BACKGROUND
  The objective of this study was to evaluate the evidence for different interventions in the preoperative, perioperative and post-operative care for people undergoing elective total hip (THR) and knee (TKR) replacement surgery.
  
  
  METHODS
  A multidisciplinary working group comprising consumers, managers and clinicians from the areas of orthopaedics, rheumatology, aged care and rehabilitation evaluated randomized controlled trials (RCTs) and systematic reviews/meta-analyses concerning aspects of preoperative, perioperative and post-operative clinical care periods for THR/TKR through systematic searching of Medline, Embase, CENTRAL and the Cochrane Database of Systematic Reviews from May 2007 to April 2011. Multiple reviewers determined study eligibility and one or more members extracted primary study findings. The body of evidence were assessed and specific recommendations made according to NHMRC guidelines.
  
  
  RESULTS
  Twenty-five aspects were identified for review. Recommendations for 16 of 25 areas of care were made: impact of waiting, multidisciplinary preparation, preoperative exercise, smoking cessation, interventions for comorbid conditions, predictors of outcome, clinical pathways, implementation of a blood management programme, antibiotic prophylaxis, regional anaesthesia and analgesia, use of a tourniquet in knee replacement, venous thromboembolism prophylaxis, early post-operative cryotherapy, early mobilization and continuous passive motion. In the post-operative period, study heterogeneity across all aspects of care precluded specific recommendations.
  
  
  CONCLUSIONS
  There was a deficiency in the quality of the evidence supporting key aspects of the continuum of care for primary THR/TKR surgery. Consequently, recommendations were limited. Prioritization and funding for research into areas likely to impact clinical practice and patient outcomes after elective joint replacement surgery are the next important steps.
authors.affiliation: Department of Geriatric Medicine, Gosford Hospital, Gosford, New South Wales, Australia; Department of Medicine, Ryde Hospital, Eastwood, New South Wales, Australia.
authors.forename: Jenson C S
authors.initials: JC
authors.lastname: Mak
authors.forename: Marlene
authors.initials: M
authors.lastname: Fransen
authors.forename: Matthew
authors.initials: M
authors.lastname: Jennings
authors.forename: Lynette
authors.initials: L
authors.lastname: March
authors.forename: Rajat
authors.initials: R
authors.lastname: Mittal
authors.forename: Ian A
authors.initials: IA
authors.lastname: Harris
mesh_terms: D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D003266:Continuity of Patient Care; D017558:Elective Surgical Procedures; D019317:Evidence-Based Medicine; D006801:Humans; D019990:Perioperative Care / Q000379:methods*
keywords: hip and knee osteoarthritis; total hip replacement; total knee replacement