title: Acellular biomaterials: an evolving alternative to cell-based therapies.
abstract: Acellular biomaterials can stimulate the local environment to repair tissues without the regulatory and scientific challenges of cell-based therapies. A greater understanding of the mechanisms of such endogenous tissue repair is furthering the design and application of these biomaterials. We discuss recent progress in acellular materials for tissue repair, using cartilage and cardiac tissues as examples of applications with substantial intrinsic hurdles, but where human translation is now occurring.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. burdick2@seas.upenn.edu
authors.forename: Jason A
authors.initials: JA
authors.lastname: Burdick
authors.forename: Robert L
authors.initials: RL
authors.lastname: Mauck
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Gorman
authors.forename: Robert C
authors.initials: RC
authors.lastname: Gorman
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006801:Humans; D009203:Myocardial Infarction / Q000628:therapy; D023822:Tissue Engineering / Q000379:methods
chemical_list: D001672:Biocompatible Materials