title: An introductory classroom exercise on protein molecular model visualization and detailed analysis of protein-ligand binding.
abstract: A learning module for molecular level analysis of protein structure and ligand/drug interaction through the visualization of X-ray diffraction is presented. Using DeepView as molecular model visualization software, students learn about the general concepts of protein structure. This Biochemistry classroom exercise is designed to be carried out by following the detailed instructions that make software handling straightforward. Students learn about protein structure and gain insight into the molecular level of the interaction of two active compounds with their receptor. © 2013 by The International Union of Biochemistry and Molecular Biology 41(2):118-124, 2013.
authors.affiliation: Instituto de Química Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario-CONICET, Argentina.
authors.forename: Poeylaut-Palena
authors.initials: PP
authors.lastname: Andrés A
authors.forename: María
authors.initials: M
authors.lastname: de Los Ángeles Laborde
mesh_terms: D001671:Biochemistry / Q000193:education*; D004958:Estradiol / Q000737:chemistry / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008024:Ligands; D008958:Models, Molecular; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D020849:Raloxifene Hydrochloride / Q000737:chemistry / Q000378:metabolism; D012984:Software; D013334:Students
chemical_list: D047628:Estrogen Receptor alpha; D008024:Ligands; D011506:Proteins; D020849:Raloxifene Hydrochloride; D004958:Estradiol