title: Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas.
abstract: BACKGROUND
  We compared aortic stiffness, aortic impedance and pressure from wave reflections in the setting of bicuspid aortic valve (BAV) to the tricuspid aortic valve (TAV) in the absence of proximal aortic dilation. We hypothesized BAV is associated with abnormal arterial stiffness.
  
  
  METHODS
  Ten BAV subjects (47 ± 4 years, 6 male) and 13 TAV subjects (46 ± 4 years, 10 male) without significant aortic valve disease were prospectively recruited. Characteristic impedance (Zc) was derived from echocardiographic images and pulse wave Doppler of the left ventricular outflow tract. Applanation tonometry was performed to obtain pulse wave velocity (PWV) at several sites as measures of arterial stiffness and augmentation index (AIx) as a measure of wave reflection.
  
  
  RESULTS
  There were no significant differences between BAV and TAV subjects with regard to heart rate or blood pressure. Zc was similar between BAV and TAV subjects (p=0.25) as was carotid-femoral pulse wave velocity (cf-PWV) and carotid-radial PWV (cr-PWV) between BAV and TAV subjects (p=0.99). Carotid AIx was significantly higher in BAV patients compared with TAV patients (14.3 ± 4.18% versus -3.02 ± 3.96%, p=0.007).
  
  
  CONCLUSIONS
  Aortic stiffness and impedance is similar between subjects with BAV and TAV with normal aortic dimensions. The significantly higher carotid AIx in BAV, a proxy of increased pressure from wave reflections, may reflect abnormal vascular function distal to the aorta.
authors.affiliation: Division of Cardiology and Vascular Function Study Group, Tufts Medical Center, Boston, MA, USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Warner
authors.forename: Adeeb
authors.initials: A
authors.lastname: Al-Quthami
authors.forename: Erica L
authors.initials: EL
authors.lastname: Brooks
authors.forename: Alyson
authors.initials: A
authors.lastname: Kelley-Hedgepeth
authors.forename: Eshan
authors.initials: E
authors.lastname: Patvardhan
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Kuvin
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Heffernan
authors.forename: Gordon S
authors.initials: GS
authors.lastname: Huggins
mesh_terms: D000328:Adult; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001021:Aortic Valve / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000503:physiopathology; D062186:Arterial Pressure; D000082882:Bicuspid Aortic Valve Disease; D016009:Chi-Square Distribution; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006339:Heart Rate; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness