title: Clinical evaluation of β-TCP in the treatment of lacunar bone defects: a prospective, randomized controlled study.
abstract: The aim of this study was to investigate the potential wide application of beta tricalcium phosphate (β-TCP) only for bone defects as compared to allograft. 95 patients with a solitary bone cyst were randomly assigned to the treatment. A new radiographic scoring system was employed to calculate the biodegradation of bone graft and to evaluate the influence of multiple factors. At an average of 28.43 months after surgery, a radiographic semi-quantitative analysis revealed that the degradation rates of β-TCP and the allograft were comparable (p>0.05). Age, complication, packing methods and granule diameters have a significant influence on β-TCP degradation. The loose packing method and 3-5mm granule size should be employed in clinical practice. A histological analysis of biopsy showed that β-TCP supported the growth of fibrous tissue, vascular tissue, as well as bone tissue into the implants. The results proved that single β-TCP is an advantageous alternative to allografts for lacunar bone defect repair and would well guide the design and clinical application of the β-TCP.
authors.affiliation: Department of Orthopaedics, Xijing hospital, Fourth Military Medical University, Xi'an 710032, PR China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Guo
authors.forename: Hua
authors.initials: H
authors.lastname: Bai
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Li
authors.forename: Guojing
authors.initials: G
authors.lastname: Chen
authors.forename: Jianxi
authors.initials: J
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001845:Bone Cysts / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D016723:Bone Remodeling / Q000187:drug effects; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D002130:Calcium Phosphates / Q000494:pharmacology* / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019736:Prostheses and Implants; D011859:Radiography; D055815:Young Adult
chemical_list: D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate