title: The ability of a novel blue laser imaging system for the diagnosis of invasion depth of colorectal neoplasms.
abstract: BACKGROUND
  Fujifilm has developed a novel endoscope system with two kinds of lasers that enables us to allow narrow-band light observation with blue laser imaging (BLI). The aim of this study was to evaluate BLI magnification in comparison with narrow-band imaging (NBI) magnification for the diagnosis of colorectal neoplasms.
  
  
  METHODS
  This was a multicenter open study. A total of 104 colorectal neoplasms were examined with BLI and NBI magnifications in Kyoto Prefectural University of Medicine and Fukuoka University Chikushi Hospital. Vascular and surface patterns of tumors under BLI magnification were compared with those under NBI magnification, using a published NBI classification. The main outcome was the correlation between the NBI classification diagnosed by BLI or NBI magnification and the histopathological analyses.
  
  
  RESULTS
  Sixty-two cases of adenoma, 34 cases of intramucosal cancer and shallowly invaded submucosal cancer, and eight cases of deeply invaded submucosal cancer were diagnosed. The diagnostic accuracy of BLI magnification in the NBI classification was 74.0 % (77/104), similar to that of NBI magnification (77.8 %). The consistency rate between BLI and NBI magnification in the NBI classification was 74.0 %. Concerning image evaluation, the interobserver variability of two expert endoscopists (N.Y. and T.H.) in BLI magnification was κ = 0.863. On the other hand, the intraobserver variability of the two endoscopists was κ = 0.893 (N.Y.) and 0.851 (T.H.).
  
  
  CONCLUSIONS
  BLI magnification by laser source could predict histopathological diagnosis and invasion depth of colorectal neoplasms. The diagnostic effectiveness of this method was similar to that of NBI magnification.
authors.affiliation: Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan, naohisa@koto.kpu-m.ac.jp.
authors.forename: Naohisa
authors.initials: N
authors.lastname: Yoshida
authors.forename: Takashi
authors.initials: T
authors.lastname: Hisabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inada
authors.forename: Munehiro
authors.initials: M
authors.lastname: Kugai
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Yagi
authors.forename: Fumihito
authors.initials: F
authors.lastname: Hirai
authors.forename: Kenshi
authors.initials: K
authors.lastname: Yao
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Matsui
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwashita
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Kato
authors.forename: Akio
authors.initials: A
authors.lastname: Yanagisawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D003113:Colonoscopy / Q000295:instrumentation / Q000379:methods; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D004867:Equipment Design; D005260:Female; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging; D009361:Neoplasm Invasiveness; D015588:Observer Variation; D015203:Reproducibility of Results