title: Characterization of a PGA-based scaffold for use in a tissue-engineered neo-urinary conduit.
abstract: A tissue-engineered product needs to be properly characterized in order to be used in vivo. Many methods can be used to characterize a scaffold during creation of a tissue-engineered product. This chapter looks at the mechanical (tensile testing) and biological characterization (cell viability and proliferation) of a polyglycolic acid-based scaffold used to tissue engineer a Neo-Urinary Conduit™. Such methods are more broadly applicable to characterization of other neo-organ product candidates.
authors.affiliation: Tengion Inc., Winston-Salem, NC, USA.
authors.forename: Toyin A
authors.initials: TA
authors.lastname: Knight
authors.forename: Richard G
authors.initials: RG
authors.lastname: Payne
mesh_terms: D049109:Cell Proliferation; D002470:Cell Survival; D003124:Colorimetry / Q000379:methods; D006801:Humans; D011100:Polyglycolic Acid / Q000378:metabolism*; D044968:Regenerative Medicine / Q000379:methods*; D013718:Tensile Strength; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014551:Urinary Tract / Q000166:cytology*
chemical_list: D011100:Polyglycolic Acid