title: Maintenance of the response to dimethyl sulfoxide treatment using hyperbaric oxygen in interstitial cystitis/painful bladder syndrome: a prospective, randomized, comparative study.
abstract: BACKGROUND
  Interstitial cystitis (IC)/painful bladder syndrome (PBS) is a difficult disease to manage and creates critical limitations in patients' daily lives. Our objective was to determine the efficacy of hyperbaric oxygen (HBO) therapy in the maintenance of response after the administration of intravesical dimethyl sulfoxide (DMSO).
  
  
  METHODS
  We conducted an open, prospective, randomized, comparative pilot study with women diagnosed with IC/PBS according to the European Society for the Study of Interstitial Cystitis criteria. In the first phase, DMSO was given to all patients. In the second phase, we used 1:1 randomization and administered HBO to 10 women. The evaluated variables were pain (through a visual analog scale), frequency and urgency of voids, nocturia, and quality of life using the O'Leary-Sant Interstitial Cystitis Score/Problem Index and the King's Health Questionnaire. In the second phase, we measured the length of time that clinical improvement was maintained.
  
  
  RESULTS
  The mean age was 47.6 years (SD 18.4). Out of 20 patients, 14 experienced clinical improvement after DMSO in all of the evaluated symptoms (p < 0.05; 95% CI). After the second phase, all patients who received HBO had a more substantive and prolonged maintenance of the effects of DMSO.
  
  
  CONCLUSIONS
  In this study, HBO improved the maintenance of the beneficial effects of DMSO among women with IC/PBS.
authors.affiliation: Department of Urology, Hospital General Castellón, Castellón, Spain. dagalvi@hotmail.com
authors.forename: Daniel
authors.initials: D
authors.lastname: Gallego-Vilar
authors.forename: Gonzalo
authors.initials: G
authors.lastname: García-Fadrique
authors.forename: Ivan
authors.initials: I
authors.lastname: Povo-Martin
authors.forename: Manuel
authors.initials: M
authors.lastname: Salvador-Marin
authors.forename: Juan
authors.initials: J
authors.lastname: Gallego-Gomez
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D018856:Cystitis, Interstitial / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D016014:Linear Models; D008875:Middle Aged; D015999:Multivariate Analysis; D010147:Pain Measurement; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life; D013997:Time Factors; D016896:Treatment Outcome; D014554:Urination / Q000187:drug effects
chemical_list: D004121:Dimethyl Sulfoxide