title: Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma.
abstract: TEX101, a member of the Ly-6/urokinase-type plasminogen activator receptor (LU)-family we previously identified, is a germ cell-marker glycoprotein. To date, it is reported that some members of the protein-family are overexpressed in a variety of cancer tissues. We previously reported Ly6k, a member of the LU-family, as an association molecule with TEX101 in murine male germ cells. LY6K (a human homologue of Ly6k) is overexpressed in head and neck squamous cell carcinomas (HNSCC). These facts led us to speculate that TEX101 may also exist in HNSCC, like LY6K. Using an anti-human TEX101 polyclonal antibody (pAb) established, we examined the expression of TEX101 protein in cancer tissues by immunohistochemical analysis. TEX101 was detected in the cancer cells of some tissue specimens from patients with HNSCC, whereas the normal squamous epithelium was immunonegative. The TEX101 protein was detected in cancer cells from 54 out of 64 (80.6%) patients with HNSCC. The rate of lymph nodes metastasis tends to be low in TEX101-positive patients, compared to patients with weakly positive and negative expression of TEX101. The present results imply that TEX101 is a novel cancer-related protein and may be useful as a marker for prognosis/diagnosis of HNSCC.
authors.affiliation: Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshitake
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yokoi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Mayuko
authors.initials: M
authors.lastname: Maruyama
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Endo
authors.forename: Michio
authors.initials: M
authors.lastname: Nojima
authors.forename: Koyo
authors.initials: K
authors.lastname: Yoshida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Fujihiko
authors.initials: F
authors.lastname: Suzuki
authors.forename: Kenji
authors.initials: K
authors.lastname: Takamori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Araki
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D015153:Blotting, Western; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; C539319:TEX101 protein, human