title: Complete form of pachydermoperiostosis: a case report.
abstract: Pachydermoperiostosis is a primary form of hypertrophic osteoarthropathy, which presents with pachydermia, digital clubbing, and radiologic periostosis. Pachydermoperiostosis occurs owing to mutations of the gene encoding for 15-hydroxyprostaglandin dehydrogenase (15HPGD). Clinical manifestations of PDP are thought to relate to excessive collagen formation and dysregulation of matrix proteins because of fibroblastic hyperactivation. We present a very rare case of the complete form of pachydermoperiostosis in a young Indian male.
authors.affiliation: Lady Hardinge Medical College, New Delhi, India.
authors.forename: Ram
authors.initials: R
authors.lastname: Chander
authors.forename: Sushil
authors.initials: S
authors.lastname: Kakkar
authors.forename: Arpita
authors.initials: A
authors.lastname: Jain
authors.forename: Meenu
authors.initials: M
authors.lastname: Barara
authors.forename: Kiran
authors.initials: K
authors.lastname: Agarwal
authors.forename: Bincy
authors.initials: B
authors.lastname: Varghese
mesh_terms: D044466:Asian People / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation; D010004:Osteoarthropathy, Primary Hypertrophic / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D010522:Periostitis / Q000209:etiology* / Q000473:pathology; D055815:Young Adult