title: Paraneoplastic hypertrophic osteopathy in 30 dogs.
abstract: Paraneoplastic hypertrophic osteopathy (pHO) is known to occur in both canine and human cancer patients. While the pathology of pHO is well-described in the dog, very little information exists regarding the true clinical presentation of dogs affected with pHO. The primary objective of this study was to provide a more comprehensive clinical picture of pHO. To this end, we retrospectively identified 30 dogs and recorded data regarding presenting complaints and physical examination (PE) findings on the date of pHO diagnosis. As a secondary objective, any blood test results were also collected from the computerized records. The most common clinical signs included leg swelling, ocular discharge and/or episcleral injection, lameness, and lethargy. The most common haematological and serum biochemical abnormalities included anaemia, neutrophilia and elevated alkaline phosphatase. In addition to presenting a more detailed clinical description of pHO in the dog, these data support the previously described haematological, serum biochemical and PE abnormalities published in individual case reports.
authors.affiliation: William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Withers
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: E G
authors.initials: EG
authors.lastname: Johnson
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: W T N
authors.initials: WT
authors.lastname: Culp
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: C O
authors.initials: CO
authors.lastname: Rodriguez
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Skorupski
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Rebhun
mesh_terms: D000818:Animals; D001344:Autopsy / Q000662:veterinary; D002140:California; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004285:Dogs; D057286:Electronic Health Records; D005260:Female; D007794:Lameness, Animal / Q000150:complications; D008175:Lung Neoplasms / Q000150:complications / Q000662:veterinary; D008297:Male; D009369:Neoplasms / Q000150:complications; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D011859:Radiography; D012189:Retrospective Studies; D012582:Schools, Veterinary
keywords: comparative oncology; imaging; metastasis; pathology; small animal