title: Neuropathology and behavioral impairments after bilateral global ischemia surgery and exposure to static magnetic field: Evidence in the motor cortex, the hippocampal CA1 region and the neostriatum.
abstract: OBJECTIVE
  To evaluate the effects of continuous magnetic field stimulation after four days of global encephalic ischemia on motor behavior and brain morphology in gerbils.
  
  
  METHODS
  Sixty Mongolian gerbils were divided into five groups: Control (CG), sham (SG), ischemia (IG), ischemia north (INPG) and south (ISPG) pole. Experimental animals underwent bilateral occlusion of the carotid artery. In groups with magnetic stimulation, a 3200 gauss magnet was fixed to the skull. After brain perfusion, coronal sections of the striatum, motor cortex (M1) and CA1 area of the hippocampus (CA1) were cut and stained with hematoxylin and eosin.
  
  
  RESULTS
  In the open field test (OF) we observed an increase in crossing in the IG compared to the CG, INPG and ISPG (F = 20.19), and a reduction in the time spent on the Rota-rod test (RR) with the IG compared to CG, IPNG and ISPG (F = 17.59). Morphometric analysis revealed a reduction in the density of the neurons in the CA1, in the number of M1 and striatal neurons in the IG compared to the CG, INPG and ISPG.
  
  
  CONCLUSIONS
  Our results demonstrate a potential therapeutic application of static magnetic fields for the preservation of motor behavior and neurons in regions analyzed after global cerebral ischemia.
authors.affiliation: Laboratory of Neuropsychobiology and Motor Behavior, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirão Preto Medical School of the University of São Paulo (USP), São Paulo, Brazil.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Bertolino
authors.forename: Fernanda Lopes Buiatti
authors.initials: FL
authors.lastname: De Araujo
authors.forename: Hugo Celso Dutra
authors.initials: HC
authors.lastname: Souza
authors.forename: Norberto Cysne
authors.initials: NC
authors.lastname: Coimbra
authors.forename: João Eduardo
authors.initials: JE
authors.lastname: De Araujo
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D056547:CA1 Region, Hippocampal / Q000473:pathology; D005849:Gerbillinae; D055909:Magnetic Field Therapy; D008297:Male; D009044:Motor Cortex / Q000473:pathology; D017072:Neostriatum / Q000473:pathology; D009474:Neurons / Q000473:pathology; D020521:Stroke / Q000150:complications