title: Roles of the epoxygenase CYP2J2 in the endothelium.
abstract: Cytochrome p450 (CYP)2J2 is an epoxygenase enzyme that metabolises arachidonic acid to epoxyeicosatrienoic acids (EETs). EETs are inactivated by soluble epoxide hydrolase (sEH), which converts them in to their corresponding dihydroxyeicosatrienoic acids (DHETs). CYP2J2 is highly expressed in cardiovascular tissue including the heart and vascular endothelial cells. CYP2J2 and the EETs it produces have been shown to have a diverse range of effects on the vasculature, including the regulation of inflammation, vascular tone, cellular proliferation, angiogenesis, and metabolism. This review will examine these established and emerging roles of CYP2J2 in the biology of vascular endothelial cells.
authors.affiliation: Translational Medicine & Therapeutics, William Harvey Research Institute, Barts & the London, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom.
authors.forename: Ara
authors.initials: A
authors.lastname: Askari
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Thomson
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Edin
authors.forename: Darryl C
authors.initials: DC
authors.lastname: Zeldin
authors.forename: David
authors.initials: D
authors.lastname: Bishop-Bailey
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000201:enzymology; D000090762:Cytochrome P-450 CYP2J2; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology*; D042783:Endothelial Cells / Q000201:enzymology; D004730:Endothelium, Vascular / Q000201:enzymology*; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D018919:Neovascularization, Physiologic
chemical_list: C000717350:CYP2J2 protein, human; D005227:Fatty Acids; D003577:Cytochrome P-450 Enzyme System; D000090762:Cytochrome P-450 CYP2J2
keywords: Angiogenesis; Dilation; Endothelial; Epoxygenase; Inflammation; Metabolism