title: Selenium-binding protein 1 may decrease gastric cellular proliferation and migration.
abstract: It has been reported that suppression of selenium‑binding protein 1 (SBP1) occurs in many human malignancies which is considered to play an important role in cancer development and progression. Despite its importance in cancer, the function and factors that regulate its expression are not known. Using cell proliferation assays, immunochemical staining and immunoblotting and flow cytometry methods and in a xenograft model, we evaluated the role of SBP1 in proliferation, migration, senescence and chemoresistance of gastric cancer cells (SGC7901 and BGC823) to cisplatin. It was noted that diminished SBP1 expression increased gastric cancer cell proliferation and cell migration and decreased cisplatin-induced apoptosis while its overexpression produced the opposite effects. These results suggest that SBP1 plays a significant role in gastric cancer cell proliferation and modulates its response to anticancer drugs. These results suggest that SBP1 can serve as a potential target to suppress gastric cancer.
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, PR China.
authors.forename: Chenjing
authors.initials: C
authors.lastname: Zhang
authors.forename: Wen
authors.initials: W
authors.lastname: Xu
authors.forename: Wensheng
authors.initials: W
authors.lastname: Pan
authors.forename: Nana
authors.initials: N
authors.lastname: Wang
authors.forename: Guogang
authors.initials: G
authors.lastname: Li
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Fan
authors.forename: Xiang
authors.initials: X
authors.lastname: Xu
authors.forename: Shengrong
authors.initials: S
authors.lastname: Shen
authors.forename: Undurti N
authors.initials: UN
authors.lastname: Das
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D017209:Apoptosis / Q000235:genetics*; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D051379:Mice; D051137:Selenium-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D051137:Selenium-Binding Proteins; D002945:Cisplatin