title: A comparative study of isolated and metachronous oesophageal squamous cell carcinoma with antecedent upper aerodigestive tract cancer.
abstract: OBJECTIVE
  Metachronous oesophageal squamous cell carcinoma (OSCC) has been increasing in long-term survivors of upper aerodigestive tract (UADT) cancers in recent years, but the treatment of such cases is not well established. The aim of this study was to compare the prognosis between patients with metachronous OSCC who had antecedent UADT cancers and patients with isolated OSCC.
  
  
  METHODS
  From January 1995 to December 2009, we retrospectively compared the data from 84 patients with metachronous OSCC who had antecedent UADT cancers (metachronous group) with the data from 527 patients with isolated OSCC (isolated group) according to their treatment modalities at Kaohsiung Chang Gung Memorial Hospital.
  
  
  RESULTS
  Overall, the metachronous group had significantly (P = 0.03) worse overall survival than the isolated group. For patients receiving surgery or preoperative chemoradiotherapy followed by surgery, the overall survival rates and incidence of postoperative complications were not significantly different. For patients receiving definite chemoradiotherapy or radiotherapy alone, the metachronous group had significantly (P = 0.02) inferior overall survival compared with the isolated group.
  
  
  CONCLUSIONS
  Offering a radical approach for the treatment of patients with metachronous OSCC who had antecedent UADT cancers is justifiable, with survival rates similar to those of patients with isolated OSCC.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Hung-I
authors.initials: HI
authors.lastname: Lu
authors.forename: Shau-Hsuan
authors.initials: SH
authors.lastname: Li
authors.forename: Wan-Ting
authors.initials: WT
authors.lastname: Huang
authors.forename: Kun-Ming
authors.initials: KM
authors.lastname: Rau
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Fang
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Wang
authors.forename: Wei-Che
authors.initials: WC
authors.lastname: Lin
authors.forename: Wan-Yu
authors.initials: WY
authors.lastname: Tien
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000628:therapy*; D004938:Esophageal Neoplasms / Q000556:secondary* / Q000628:therapy*; D000077277:Esophageal Squamous Cell Carcinoma; D016629:Esophagectomy; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000628:therapy*; D012189:Retrospective Studies; D013624:Taiwan
keywords: Metachronous cancer; Oesophageal squamous cell carcinoma; Oesophagectomy; Radiotherapy; Upper aerodigestive tract cancer