title: Effect of vitamin supplementation on serum oxidized low-density lipoprotein levels in male subjects with cardiovascular disease risk factors.
abstract: OBJECTIVE
  Oxidized low-density lipoproteins (ox-LDLs) appear to play a significant role in atherogenesis. In fact, circulating ox-LDL concentrations have been recognized as a risk factor for cardiovascular disease (CVD). The main objectives of this study were to assess the effects of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD risk factors.
  
  
  METHODS
  The effect of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD in male subjects with CVD risk factors at baseline and after 12 weeks of supplementation with vitamin E (400 IU), C (500 mg), ß-carotene (15 mg), and the combined supplements (E, C, and ß-carotene) respectively defined as group E, C, B and control group was considered as group P.
  
  
  RESULTS
  The mean values for ox-LDL at the baseline were 86.93 ± 26.30 U/l in group C, 94.52 ± 38.40 U/l in group E, 79.73±2.07 U/l in group B, 85.97±23.07 U/l in combined group, and 84.90± 14.66 U/l in group P. After 12 weeks of intervention the percentage of changes for group C, group E, group B, COM group, and group P were (-18.32), (-2286), (-17.31), (-19.01) and (-2.0), respectively. Using Wilcoxon method, significant differences were detected in the mean ox-LDL concentrations of baseline and after intervention, values in the C, E, B and combined groups (P< 005).
  
  
  CONCLUSIONS
  This study illustrated that diet supplemented with vitamin C (500 mg), vitamin E (400 IU), ß-carotene (15 mg), and the combination of these vitamins was associated with lower serum ox-LDL levels.
authors.affiliation: Faculty of Health, Bushehr University of Medical Sciences. Bushehr, Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Najafpour Boushehri
authors.forename: Rokiah Mohammad
authors.initials: RM
authors.lastname: Yusof
authors.forename: Mohammad
authors.initials: M
authors.lastname: Nasir Mohammad Taib
authors.forename: Kamran
authors.initials: K
authors.lastname: Mirzaei
authors.forename: Narges
authors.initials: N
authors.lastname: Yazdekhasti
authors.forename: Samad
authors.initials: S
authors.lastname: Akbarzadeh
keywords: Cardiovascular Diseases; Oxidized Low-Density Lipoprotein; Vitamin C; Vitamin E; ß-carotene