title: Epidemiology of mecA-Methicillin Resistant Staphylococcus aureus (MRSA) in Iran: A Systematic Review and Meta-analysis.
abstract: OBJECTIVE
  Staphylococcus aureus (S. aureus) is a prevalent pathogen worldwide. Methicillin resistant S. aureus (MRSA), which is usually multi-resistant in hospitals, has been a daunting challenge for clinicians for more than half a century. The aim of this systematic review and meta-analysis is to determine the relative frequency (R.F.) of MRSA in different regions of Iran.
  
  
  METHODS
  Search terms "Staphylococcus aureus", "Methicillin", "mecA" and "Iran" were used in PubMed, Scirus and Google Scholar. Two Persian scientific search engines and ten recent national congresses were also explored. Articles/abstracts, which used clinical specimens and had done PCR to detect the mecA gene, were included in this review. Comprehensive Meta-Analysis and Meta-Analyst software were used for statistical analysis.
  
  
  RESULTS
  Out of 2690 results found in the mentioned databases, 48 articles were included in the final analysis. These studies were done in Ahvaz, Falavarjan, Fasa, Gorgan, Hamedan, Isfehan, Kashan, Mashhad, Sanandaj, Shahrekord, Shiraz, Tabriz, Tehran and Tonekabon. Pooled estimation of 7464 S. aureus samples showed that 52.7%±4.7 (95% confidence interval [CI]) of strains were mecA positive. MRSA R.F. in different studies varied from 20.48% to 90% in Isfehan and Tehran, respectively. We found a moderate heterogeneity (I(2)= 48.5%) of MRSA R.F. among studies conducted in Tehran (ranging from 28.88% to 90%, mean 52.7% [95% CI: 46.6%±0.58.8%]).
  
  
  CONCLUSIONS
  According to the results of this study, MRSA R.F. in Iran is in the high range. Thus, measures should be taken to keep the emergence and transmission of these strains to a minimum.
authors.affiliation: Mashhad Medical Microbiology Student Research Group, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Emran
authors.initials: E
authors.lastname: Askari
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Soleymani
authors.forename: Arash
authors.initials: A
authors.lastname: Arianpoor
authors.forename: Seyed Meghdad
authors.initials: SM
authors.lastname: Tabatabai
authors.forename: Aminreza
authors.initials: A
authors.lastname: Amini
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Naderinasab
keywords: Iran; MRSA; Staphylococcus aureus; Systematic Review; mecA gene