title: Favorable outcome under anticoagulant therapy in a high risk pregnancy case report and short review of the (recent) literature.
abstract: The incidence of venous thromboembolism is significantly increased during pregnancy, recurrent venous thromboembolism being a serious complication because it is potentially life-threatening. According to recent ACCP guidelines, women with "high-risk" thrombophilias (e.g., homozygosity for factor V Leiden) who had a single prior episode of VTE treated with oral anticoagulants, should receive LMWH or UFH during pregnancy and puerperium, followed by resumption of long-term anticoagulants postpartum.We present the case of a young woman with a history of severe deep vein thrombosis of the inferior vena cava, occurring during oral contraceptive use. Subsequent investigation revealed homozygosity for Leiden mutation. She was treated with enoxaparin throughout gestation and 6 weeks postpartum and no complications appeared.
authors.affiliation: Department of Hematology, Emergency University Hospital, Bucharest, Romania.
authors.forename: Irina
authors.initials: I
authors.lastname: Voican
authors.forename: Prof Ana Maria
authors.initials: PA
authors.lastname: Vladareanu
authors.forename: Minodora
authors.initials: M
authors.lastname: Onisai
authors.forename: Anca
authors.initials: A
authors.lastname: Nicolescu
authors.forename: Prof Radu
authors.initials: PR
authors.lastname: Vladareanu
keywords: anticoagulant therapy; pregnancy; thromboembolism