title: Host-guest inclusion system of mangiferin with β-cyclodextrin and its derivatives.
abstract: The characterization, inclusion complexation behavior and binding ability of the inclusion complexes of mangiferin (MGF) with β-cyclodextrin and its derivatives (hydroxypropyl-β-cyclodextrin (HPβCD), sulfobutyl ether β-cyclodextrin (SBEβCD) and mono (6-ethylene-diamino-6-deoxy)-β-cyclodextrin (ENβCD)) were investigated in both solution and solid state by means of PL spectroscopy, (1)H and 2D NMR, XRD, TG and DSC. The results showed that the water solubility and thermal stability of MGF were significantly increased in the inclusion complex with cyclodextrins. The MGF/CDs complexes will be potentially useful for the design of a novel formulation of mangiferin for herbal medicine.
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Yang
authors.forename: Yulin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yunjian
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiali
authors.initials: X
authors.lastname: Liao
authors.forename: Chuanzhu
authors.initials: C
authors.lastname: Gao
authors.forename: Dan
authors.initials: D
authors.lastname: Xiao
authors.forename: Qixue
authors.initials: Q
authors.lastname: Qin
authors.forename: Dong
authors.initials: D
authors.lastname: Yi
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D011208:Powders; D012995:Solubility; D013050:Spectrometry, Fluorescence; D013816:Thermodynamics; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D044004:Xanthones / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D011208:Powders; D044004:Xanthones; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C013592:mangiferin; C093196:SBE4-beta-cyclodextrin