title: Effect of adiponectin gene polymorphisms on waist circumference in patients with diabetes.
abstract: BACKGROUND
  Plasma levels of adiponectin which is secreted from adipose tissue are associated with various parameters of metabolic syndrome. This effect seems to be a result of interactions between genetic and environmental factors including central obesity. The present study was carried out to investigate the possibility of relation between single nucleotide polymorphisms of adiponectin gene (+45 T/G and -11391 G/A) and waist circumferences (WC) in patients with type 2 diabetes.
  
  
  METHODS
  This cross-sectional study was conducted on n = 238 diabetic patients selected as cases and n = 159 as healthy control who were recruited from Rafsanjan city in south - east of Iran. The possible association of +45 T/G and -11391 G/A adiponectin gene polymorphisms with WC according to age and sex was evaluated.
  
  
  RESULTS
  There was no significant difference in distribution of frequencies of +45 T/G and -11391 G/A adiponectin gene polymorphisms in each group. We only found a significant association between -11391 G/A adiponectin gene polymorphism with WC in diabetic group (p = 0.021). This association was remained significant after adjustment in multivariate regression model (p = 0.019, OR: 0.244, 95%CI: 0.075-0.791) and also this effect was independent of sex and age.
  
  
  CONCLUSIONS
  We found higher abdominal obesity in GA or AA carriers of adiponectin - 11391 G/A genotype in type 2 diabetes patients independent of age and sex.
authors.affiliation: Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran. amolimm@tums.ac.ir.
authors.forename: Shirin
authors.initials: S
authors.lastname: Hasani-Ranjbar
authors.forename: Mahsa M
authors.initials: MM
authors.lastname: Amoli
authors.forename: Ozra
authors.initials: O
authors.lastname: Tabatabaei-Malazy
authors.forename: Yalda
authors.initials: Y
authors.lastname: Rumi
authors.forename: Javad
authors.initials: J
authors.lastname: Tavakkoly-Bazzaz
authors.forename: Hilda
authors.initials: H
authors.lastname: Samimi
authors.forename: Elnaz
authors.initials: E
authors.lastname: Abbasifarid