title: Advances in molecular diagnostics of myeloproliferative disorders.
abstract: Incremental advances in the molecular pathogenesis of myeloproliferative disorders (MPDs) have had a substantial impact on clinical practice in terms of both diagnosis and treatment. An array of novel molecular methods are being developed and integrated into the current battery of tests for diagnosis and monitoring of treatment response. Primarily, subjective clinico-histologic approaches to diagnosis are being replaced by more objective semimolecular diagnostic algorithms. Furthermore, identification of disease-specific molecular markers has facilitated the development of small-molecule drugs for targeted therapy. This review provides an overview of MPDs with emphasis on molecular diagnostic tests and their incorporation into contemporary diagnostic and therapeutic algorithms.
authors.affiliation: Associate Professor, Tata Memorial Hospital, Division of Medical Oncology, Mumbai, India.
authors.forename: Brijesh
authors.initials: B
authors.lastname: Arora
authors.forename: Ayalew
authors.initials: A
authors.lastname: Tefferi