title: New self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymer methoxy poly (ethylene glycol)-block-poly (ε-caprolactone).
abstract: The objective of the study is to prepare a new self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymers methoxy poly (ethylene glycol)-block-poly (ε-caprolactone) (MPEG-b-PCL) and to investigate the effect of MPEG-b-PCL on the characteristics of SNEDDS. MPEG-b-PCL was synthesized and characterized by (1)H-NMR, IR and GPC. Various ratios of MPEG-b-PCL copolymers and Tween 80 were used as emulsifier to prepare the new SNEDDS. SNEDDS with high oil and low surfactant content forms a semi-solid gel at room temperature, which could be effectively sealed in soft or hard capsules. The mean droplet size of SNEDDS-generated nanoemulsions significantly decreased after the addition of diblock polymer and increased with increase of PCL chain in MPEG-b-PCL. The drug Coenzyme Q10 (CoQ10) was chosen as the model compound in this study due to its insolubility in water. CoQ10 from SNEDDS was rapidly dissolved regardless of the fluid condition.
authors.affiliation: Department of Pharmaceutical Engineering, Shanghai Key Lab New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
authors.forename: Fuzheng
authors.initials: F
authors.lastname: Ren
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Jialei
authors.initials: J
authors.lastname: Chen
authors.forename: Qiufang
authors.initials: Q
authors.lastname: Jing
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
mesh_terms: D002208:Caproates / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D045703:Emulsifying Agents / Q000008:administration & dosage / Q000138:chemical synthesis*; D007783:Lactones / Q000008:administration & dosage / Q000737:chemistry*; D054118:Nanospheres / Q000008:administration & dosage / Q000737:chemistry*; D011091:Polyesters / Q000008:administration & dosage / Q000138:chemical synthesis*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000138:chemical synthesis*; D011136:Polysorbates / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D002208:Caproates; D045703:Emulsifying Agents; D007783:Lactones; D011091:Polyesters; D011136:Polysorbates; C439611:methoxy poly(ethylene glycol-co-epsilon-caprolactone); D011092:Polyethylene Glycols; C121056:caprolactone