title: Fusaodavinvin, a novel metabolite containing sulfur from the endophytic fungus Fusarium sp. (CTGU-ZL-34).
abstract: A novel metabolite containing sulfur, fusaodavinvin (1), was isolated from an endophytic fungus Fusarium sp.(CTGU-ZL-34), together with seven known compounds 2-8, and their structures were elucidated by NMR spectroscopy and MS. This is the first record of 3-(2R-hydroxyl-1-one-propane)-indole (compound 2) from nature. The isolated compounds were evaluated using the A549, Hep G2, Caski and MCF-7 cell lines by the MTT method, and compound 1 displayed significant inhibiting activity of four cancer cell lines with IC50 values of 11.5, 15.3, 15.2 and 60.5 microg/mL, respectively. However, compound 2 displayed no significant anticancer activity to the above four cancer cell lines.
authors.affiliation: Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang, 443002, P. R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhangshuang
authors.initials: Z
authors.lastname: Deng
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Guo
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Chen
authors.forename: Xuan
authors.initials: X
authors.lastname: Tu
authors.forename: Kun
authors.initials: K
authors.lastname: Zou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry / Q000378:metabolism; D005670:Fusarium / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D061986:MCF-7 Cells; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification*; D013455:Sulfur / Q000378:metabolism; D013457:Sulfur Compounds / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011753:Pyrones; D013457:Sulfur Compounds; C579670:fusaodavinvin; D013455:Sulfur