title: Utility of the AD8 as a self-rating tool for cognitive impairment in an Asian population.
abstract: BACKGROUND
  AD8 is a brief informant interview used to detect early cognitive change. This study evaluated the diagnostic performance of the participant-rated AD8 (p-AD8) in a predominantly Chinese population.
  
  
  METHODS
  Data on demographics, clinical, and cognitive features were collected from 73 participants with no cognitive impairment (NCI), 27 participants with mild cognitive impairments, and 78 participants with Alzheimer's disease-informant dyads. Agreement and discriminative properties of p-AD8 were assessed.
  
  
  RESULTS
  AD8 scores were associated with dementia severity. Participant and informant AD8 scores were moderately correlated within dementia dyads. The p-AD8 showed good diagnostic performance in differentiating between participants with NCI and participants with cognitive impairment (sensitivity = 85.0%, specificity = 74.0%, and area under the curve = 0.80), with a cutoff score of ≥1. Combination of impairment in Mini-Mental State Examination and p-AD8 is more useful in detecting cognitive impairment than using the AD8 alone.
  
  
  CONCLUSIONS
  Within a transcultural setting, the p-AD8 demonstrated good discriminative validity and can be used to gain a preliminary understanding of an individual's cognitive status.
authors.affiliation: Department of Neurology, National Neuroscience Institute, Singapore.
authors.forename: Rowena
authors.initials: R
authors.lastname: Chin
authors.forename: Amanda
authors.initials: A
authors.lastname: Ng
authors.forename: Kaavya
authors.initials: K
authors.lastname: Narasimhalu
authors.forename: Nagaendran
authors.initials: N
authors.lastname: Kandiah
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000208:ethnology; D044466:Asian People; D003072:Cognition Disorders / Q000175:diagnosis* / Q000208:ethnology; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000208:ethnology; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods* / Q000592:standards; D008875:Middle Aged; D015999:Multivariate Analysis; D011594:Psychometrics / Q000379:methods / Q000592:standards; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index