title: Single-cell resolution diagnosis of cancer cells by carbon nanotube electrical spectroscopy.
abstract: We report the use of vertically aligned carbon nanotubes (VACNTs) as electrical endoscopes (biosensors) for cancer metastatic diagnosis at single-cell resolution. The device is based on direct signal extraction by means of vertically aligned conductive carbon nanotubes from a live cell membrane, which has been disrupted during carcinogenesis at its primary and progressive stages. The value of this electrical disruption depends on the cancer metastatic grade. In addition, the electrical resonance behavior of the cell, halted during cancer progression, could be monitored as a new cancer diagnostic profile. By taking a second derivative of the cell impedance with respect to applied frequency, we have arrived at a new spectroscopy tool for distinguishing cancerous stages of colon and breast carcinoma cells.
authors.affiliation: Nano-Electronics center of excellence, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Abdolahad
authors.forename: M
authors.initials: M
authors.lastname: Janmaleki
authors.forename: M
authors.initials: M
authors.lastname: Taghinejad
authors.forename: H
authors.initials: H
authors.lastname: Taghnejad
authors.forename: F
authors.initials: F
authors.lastname: Salehi
authors.forename: S
authors.initials: S
authors.lastname: Mohajerzadeh
mesh_terms: D015374:Biosensing Techniques; D001943:Breast Neoplasms / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology; D058266:Dielectric Spectroscopy / Q000379:methods*; D005260:Female; D019073:HT29 Cells; D006801:Humans; D057230:Limit of Detection; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D009367:Neoplasm Staging / Q000379:methods*; D009369:Neoplasms / Q000473:pathology*; D059010:Single-Cell Analysis / Q000379:methods*; D013499:Surface Properties; D014407:Tumor Cells, Cultured
chemical_list: D037742:Nanotubes, Carbon