title: The clinical and immunomodulatory effects of green soybean extracts.
abstract: The present study was performed to investigate the immune-modulating activities of extracts from green soybean (Glycine max) in a 2,4-toluene diisocyanate (TDI)-inducing guinea pig rhinitis model and a human trial study for allergic rhinitis. Hot water extracts of green soybean were chosen for animal experimentation on the basis of their ability to regulate the production of B cell-activating factor of the TNF family and a proliferation-inducing ligand in mouse spleen cells. Green soybean extracts significantly decreased the levels of ovalubumin (OVA)-specific IgE in mice and significantly suppressed the TDI-induced nasal mucosa secretion. An open-label human pilot study was performed on 16 subjects, using Japanese cedar pollinosis. The symptom scores for Japanese cedar pollinosis were better in the long-term green soybean extracts intake group than in the withdrawal short-term intake group. Green soybean extracts had great potential as an orally active immune modulator for the treatment of various allergic diseases.
authors.affiliation: Health Care Research Center, Nisshin Pharma Inc., 5-3-1, Fujimino, Saitama 356-8511, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Katayanagi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Yasui
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ikemoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Taguchi
authors.forename: Ryuta
authors.initials: R
authors.lastname: Fukutomi
authors.forename: Mamoru
authors.initials: M
authors.lastname: Isemura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakayama
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Imai
mesh_terms: D000328:Adult; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007155:Immunologic Factors / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D010865:Pilot Projects; D010936:Plant Extracts / Q000008:administration & dosage*; D011058:Pollen / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology*; D012639:Seeds / Q000737:chemistry / Q000254:growth & development; D013025:Glycine max / Q000737:chemistry* / Q000254:growth & development
chemical_list: D007155:Immunologic Factors; D010936:Plant Extracts; D007073:Immunoglobulin E