title: Allosteric controls of nuclear receptor function in the regulation of transcription.
abstract: Nuclear receptors control a large number of physiological events through the regulation of gene transcription. Their activation function involves and is controlled by ligands and multiple cofactors (repressors, activators and bridging proteins). Further post-translational modifications resulting from the crosstalk between different signaling pathways provide additional regulations. The numerous players involved allow the sophisticated fine-tuning of transcriptional regulation. The present review describes how allosteric mechanisms are used in the control of the sequential and ordered binding of nuclear receptors and the various protein effectors to target DNA.
authors.affiliation: Department of Integrated Structural Biology, Institute of Genetics and Molecular and Cellular Biology, Centre National de la Recherche Scientifique, UMR 7104, Institut National de la Santé et de la Recherche Médicale U964, Université de Strasbourg, Illkirch 67404, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Billas
authors.forename: Dino
authors.initials: D
authors.lastname: Moras
mesh_terms: D000494:Allosteric Regulation; D018360:Crystallography, X-Ray; D005786:Gene Expression Regulation; D008954:Models, Biological; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D011487:Protein Conformation; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear