title: A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect.
abstract: The utility of allogeneic stem cell transplantation for treating hematologic malignancies is enhanced by the graft vs. tumor (GvT) effect, but limited by graft vs. host disease (GvHD). Studies involving the inhibition of CD73 by genetic or pharmacologic means suggest that the levels of CD73-generated adenosine may be manipulated to control GvHD, while maintaining the GvT effect.
authors.affiliation: Oklahoma Medical Research Foundation; Oklahoma City, OK USA.
authors.forename: Linda F
authors.initials: LF
authors.lastname: Thompson
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: Petya
authors.initials: P
authors.lastname: Chernogorova
authors.forename: Robert
authors.initials: R
authors.lastname: Zeiser
keywords: CD73; adenosine receptor; graft vs. host disease; graft vs. tumor effect