title: An investigation of 125I seed permanent implantation for recurrent carcinoma in the head and neck after surgery and external beam radiotherapy.
abstract: BACKGROUND
  A preliminary assessment was conducted of the feasibility, efficacy, and morbidity of 125I seed implantation for recurrent head and neck carcinoma after surgery and external beam radiotherapy.
  
  
  METHODS
  Nineteen patients with recurrent head and neck carcinomas underwent 125I seed implantation under ultrasound or computed tomography guidance. The actuarial D90 of 125I seed implantation ranged from 90 to 160 Gy (median, 131 Gy). The follow-up period ranged from 3 to 44 months (median, 11 months).
  
  
  RESULTS
  The median local control was 24 months (95% confidence interval, 10.2 to 37.8). The one- year, two-year and three-year local controls were 73.3%, 27.5% and 27.5%, respectively, whereas the one-year, two-year and three-year survival rates were 53.0%, 18.2% and 18.2%, respectively, and the median survival was 13 months (95% confidence interval, 6.6 to 19.4). A total of 26.3% of patients (5/19) died of local recurrence and 21.1% of patients (4/19) died of metastases. One suffered from a grade 1 skin reaction.
  
  
  CONCLUSIONS
  125I seed implantation is feasible and safe as a salvage treatment for patients with recurrent head and neck cancers. The high local control results and low morbidity merits further investigation.
authors.affiliation: Department of Radiation Oncology, Peking University 3rd Hospital, No, 49 Huayuan North road, Haidian district, Beijing, 100191, People's Republic of China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Zhu
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Junjie
authors.initials: J
authors.lastname: Wang
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Ran
authors.forename: Huishu
authors.initials: H
authors.lastname: Yuan
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.forename: Ang
authors.initials: A
authors.lastname: Qu
authors.forename: Ruijie
authors.initials: R
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000628:therapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000532:radiotherapy* / Q000628:therapy; D009367:Neoplasm Staging; D011874:Radiometry; D011880:Radiotherapy Planning, Computer-Assisted; D016879:Salvage Therapy; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes