title: Morphofunctional characteristics of fibroblasts and fibrogenesis in the lungs of mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus.
abstract: Mice C57Bl/6 were intranasally infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The expression of influenza A virus antigen in the lung interstitium fibroblasts was recorded during all periods of the study (on days 1-14 after infection), the maximum expression on days 1 and 3. On day 1, the volume density of collagen fibers in the lungs was 3-fold higher than in intact animals; by day 14 it increased almost 15-fold. The numerical density of PCNA(+)fibroblasts increased almost 2-fold from day 1 to day 10; "fibroplastic activity" of fibroblasts increased more than 3-fold.
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. potapova@soramn.ru
authors.forename: A G
authors.initials: AG
authors.lastname: Anikina
authors.forename: O V
authors.initials: OV
authors.lastname: Potapova
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupy
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D003094:Collagen / Q000032:analysis; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000473:pathology*; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology / Q000502:physiology; D008168:Lung / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000473:pathology* / Q000821:virology; D011658:Pulmonary Fibrosis / Q000473:pathology* / Q000821:virology
chemical_list: D000956:Antigens, Viral; D003094:Collagen