title: Gastric bypass and sleeve gastrectomy: the same impact on IL-6 and TNF-α. Prospective clinical trial.
abstract: BACKGROUND
  Due to the association between the quantity of adipose tissue and concentrations of interleukin-6 (IL-6) and tumor necrosis factor (TNF-α), this work aimed to assess the effects of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) procedures on serum IL-6 and TNF-α concentrations.
  
  
  METHODS
  This study evaluated serum IL-6 and TNF-α levels, as well as routine anthropometric and biochemical values, before and 1 year post-bariatric surgery. Fifty percent of patients (n = 24) underwent RYGB, and 50 % (n = 24) underwent SG. Prior to bariatric surgery, IL-6 and TNF-α mRNA expression levels in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were investigated in obese women.
  
  
  RESULTS
  There was a significant reduction (p < 0.05) in all anthropometric and routine biochemical measurements in patients in the RYGB and SG groups 1 year post-surgery. The serum concentrations of IL-6 and TNF-α were reduced following surgery in both groups (p < 0.05). No differences in the relative expression levels of IL-6 and TNF-α were found between SAT and VAT prior to bariatric surgery.
  
  
  CONCLUSIONS
  RYGB and SG procedures demonstrated a similar impact on adipokine levels in women 1 year post-surgery. Both techniques may improve the course of chronic diseases and the state of inflammation associated with obesity.
authors.affiliation: Department of Physiological Sciences, Federal University of Espírito Santo, Rua Marechal Campos, 1468 Vitória, CEP: 29040-090, ES, Brazil. elainecviana@gmail.com
authors.forename: Elaine Cristina
authors.initials: EC
authors.lastname: Viana
authors.forename: Karine L
authors.initials: KL
authors.lastname: Araujo-Dasilio
authors.forename: Gustavo Peixoto Soares
authors.initials: GP
authors.lastname: Miguel
authors.forename: Josefina
authors.initials: J
authors.lastname: Bressan
authors.forename: Elenice Moreira
authors.initials: EM
authors.lastname: Lemos
authors.forename: Margareth Ribeiro
authors.initials: MR
authors.lastname: Moyses
authors.forename: Gláucia Rodrigues
authors.initials: GR
authors.lastname: de Abreu
authors.forename: João Luiz Moreira Coutinho
authors.initials: JL
authors.lastname: de Azevedo
authors.forename: Perseu Seixas
authors.initials: PS
authors.lastname: Carvalho
authors.forename: Maria Rita S
authors.initials: MR
authors.lastname: Passos-Bueno
authors.forename: Flávia Imbroisi Valle
authors.initials: FI
authors.lastname: Errera
authors.forename: Nazaré Souza
authors.initials: NS
authors.lastname: Bissoli
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D005260:Female; D015390:Gastric Bypass; D015391:Gastroplasty; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism*; D009767:Obesity, Morbid / Q000378:metabolism* / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D015431:Weight Loss
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha