title: Synthesis and antitumor activity of novel chalcone derivatives.
abstract: A novel series of chalcone derivatives containing pyrimidinyl group were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines. Most of the prepared compounds showed potential cytotoxicity against several human cancer cell lines. The compound 5g displayed more potent cytotoxic activities against human cancer cell lines in comparison with Curcumin.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152, Luoyu Road, Wuhan 430079, PR China.
authors.forename: Chuanfei
authors.initials: C
authors.lastname: Jin
authors.forename: Yong-Ju
authors.initials: YJ
authors.lastname: Liang
authors.forename: Hongwu
authors.initials: H
authors.lastname: He
authors.forename: Liwu
authors.initials: L
authors.lastname: Fu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002599:Chalcone / Q000138:chemical synthesis* / Q000627:therapeutic use; D003474:Curcumin / Q000138:chemical synthesis / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D020014:K562 Cells; D061986:MCF-7 Cells; D009369:Neoplasms / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002599:Chalcone; D003474:Curcumin