title: Comparison of beneficial actions of non-steroidal anti-inflammatory drugs to flavonoids.
abstract: Inflammation is involved in increasing number of diseases necessitating the development of new, effective and safe treatments. Non steroidal anti-inflammatory drugs (NSAIDs) have been helpful in many instances, but they only inhibit cyclooxygenase (COX), but not the generation or actions of cytokines. Instead, some natural flavonoids have multiple anti-inflammatory effects, including COX inhibition, and a much safer profile. Increasing evidence indicates that inflammation plays a critical role in the pathogenesis of many diseases that also involve mast cells. Consequently, the need for new, effective and safe anti-inflammatory drugs is all the more urgent. Corticosteroids are quite potent, but have many adverse effects such as increased risk of infections, osteoporosis, glaucoma and depression. Biological agents such anti-TNF are useful in certain conditions, such as rheumatoid arthritis and psoriasis, but has been associated with increased risk of infection and leukemia.
authors.forename: P
authors.initials: P
authors.lastname: Conti
authors.forename: G
authors.initials: G
authors.lastname: Varvara
authors.forename: G
authors.initials: G
authors.lastname: Murmura
authors.forename: S
authors.initials: S
authors.lastname: Tete
authors.forename: G
authors.initials: G
authors.lastname: Sabatino
authors.forename: A
authors.initials: A
authors.lastname: Saggini
authors.forename: M
authors.initials: M
authors.lastname: Rosati
authors.forename: E
authors.initials: E
authors.lastname: Toniato
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.forename: F
authors.initials: F
authors.lastname: Pandolfi
authors.forename: G
authors.initials: G
authors.lastname: Potalivo
authors.forename: R
authors.initials: R
authors.lastname: Galzio
authors.forename: T C
authors.initials: TC
authors.lastname: Theoharides
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D047311:Luteolin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D047311:Luteolin