title: The pup-proteasome system of Mycobacterium tuberculosis.
abstract: Proteasomes are ATP-dependent protein degradation machines present in all archaea and eukaryotes, and found in several bacterial species of the order Actinomycetales. Mycobacterium tuberculosis (Mtb), an Actinomycete pathogenic to humans, requires proteasome function to cause disease. In this chapter, we describe what is currently understood about the biochemistry of the Mtb proteasome and its role in virulence. The characterization of the Mtb proteasome has led to the discovery that proteins can be targeted for degradation by a small protein modifier in bacteria as they are in eukaryotes. Furthermore, the understanding of proteasome function in Mtb has helped reveal new insight into how the host battles infections.
authors.affiliation: Department of Microbiology, New York University School of Medicine, 550 First Avenue, MSB 236, New York, NY, 10016, USA.
authors.forename: Marie I
authors.initials: MI
authors.lastname: Samanovic
authors.forename: Huilin
authors.initials: H
authors.lastname: Li
authors.forename: K Heran
authors.initials: KH
authors.lastname: Darwin
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000201:enzymology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D059748:Proteolysis; D014452:Ubiquitins / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; C533288:Pup protein, Mycobacterium tuberculosis; D014452:Ubiquitins; D046988:Proteasome Endopeptidase Complex