title: Changes in brain cortex sensitivity to epileptogens under conditions of ketogenic diet.
abstract: The epileptogenic effects of applications of NMDA and kainic acid solutions to the frontal cortex were attenuated in rats receiving ketogenic diet (80% lipids, 3.3% carbohydrates, and 16.7% proteins) during 4 weeks. Spike latency increased, the power of focal epileptic activity decreased, and focus lifetime was shortened in these animals. Sodium benzylpenicillin and strychnine nitrate less markedly reduced epileptogenic activity.
authors.affiliation: Odessa National Medical University, Ukraine.
authors.forename: V I
authors.initials: VI
authors.lastname: Kresyun
authors.forename: V A
authors.initials: VA
authors.lastname: Polyasny
authors.forename: V V
authors.initials: VV
authors.lastname: Godovan
authors.forename: L S
authors.initials: LS
authors.lastname: Godlevsky
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D055423:Diet, Ketogenic; D004827:Epilepsy / Q000139:chemically induced / Q000178:diet therapy*; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D010400:Penicillin G / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013331:Strychnine / Q000627:therapeutic use
chemical_list: D016202:N-Methylaspartate; D013331:Strychnine; D010400:Penicillin G; D007608:Kainic Acid