title: Pre-sporulation stages of Streptomyces differentiation: state-of-the-art and future perspectives.
abstract: Streptomycetes comprise very important industrial bacteria, producing two-thirds of all clinically relevant secondary metabolites. They are mycelial microorganisms with complex developmental cycles that include programmed cell death (PCD) and sporulation. Industrial fermentations are usually performed in liquid cultures (large bioreactors), conditions in which Streptomyces strains generally do not sporulate, and it was traditionally assumed that there was no differentiation. In this work, we review the current knowledge on Streptomyces pre-sporulation stages of Streptomyces differentiation.
authors.affiliation: Área de Microbiología, Departamento de Biología Funcional, and IUBA, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Yagüe
authors.forename: Maria T
authors.initials: MT
authors.lastname: López-García
authors.forename: Beatriz
authors.initials: B
authors.lastname: Rioseras
authors.forename: Jesús
authors.initials: J
authors.lastname: Sánchez
authors.forename: Angel
authors.initials: A
authors.lastname: Manteca
mesh_terms: D008954:Models, Biological; D013171:Spores, Bacterial / Q000166:cytology* / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D013302:Streptomyces / Q000166:cytology* / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism