title: RIG-I goes beyond naked recognition.
abstract: It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors.
authors.affiliation: Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.
authors.forename: J Bradford
authors.initials: JB
authors.lastname: Bowzard
authors.forename: Priya
authors.initials: P
authors.lastname: Ranjan
authors.forename: Suryaprakash
authors.initials: S
authors.lastname: Sambhara