title: [Roles of trichorhinophalangeal syndrome-1 gene in normal breast development and breast cancer].
abstract: GATA transcription factor family members have been found to involve in the growth and differentiation of mammary gland. Among them GATA-3 is regarded as the most critical regulator involving the tumorigenesis of breast cancer (BC). Recently, trichorhinophalangeal syndrome-1 gene (TRPS-1), a new GATA family member, has been identified to be highly prevalent in breast cancer. Compared with ER-negative breast cancer, the expression of TRPS-1 is higher in ER-positive breast cancer and was significantly correlates with estrogen receptor, progesterone receptor, and GATA-3, indicating it may serve as a ductal epithelial cell-specific regulator in the differentiation of breast ductal epithelial cells. Studies have shown that miR221/222 is able to downregulate the expression of an epithelial cell marker E-cadherin by targeting TRPS-1, resulting in mammary epithelial cells transition to mesenchymal cell (EMT). In addition, it has been well accepted that, and the Science and Technology Bureau of Jiaxing (2012AY1071-2)TRPS-1 plays a role in the differentiation of several other cell types including kidney nephric mesenchymal cells, columnar chondrocytes, and osteoclasts, indicating that TRPS-1 involves in mesenchymal-to-epithelial cell transition (MET). In this article, we summarize the roles of GATA transcription factor TRPS-1 in ductal epithelial cells and the roles of its gene and protein expressions in predicting the prognosis of breast cancer.
authors.affiliation: Central Laboratory, the Second Hospital of Jiaxing, Jiaxing, Zhejiang, China. ybao2011@gmail.com
authors.forename: Yi
authors.initials: Y
authors.lastname: Bao
authors.forename: Zheng-xiang
authors.initials: ZX
authors.lastname: Zhong
authors.forename: Ge
authors.initials: G
authors.lastname: Cui
authors.forename: Li
authors.initials: L
authors.lastname: Guo
authors.forename: Zhao-feng
authors.initials: ZF
authors.lastname: Wang
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics*; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D050990:GATA3 Transcription Factor / Q000235:genetics; D006801:Humans; D012097:Repressor Proteins; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D012097:Repressor Proteins; C108387:TRPS1 protein, human; D014157:Transcription Factors