title: [Association of polymorphism TaqI of vitamin de receptor with bone mineral density in young Mexican women].
abstract: BACKGROUND
  Osteoporosis is a multifactorial disease characterized by a low bone mineral density (BMD). Osteoporosis and the occurrence of fractures in postmenopausal women have been associated to the TaqI polymorphism in the vitamin D receptor (VDR) gene.
  
  
  OBJECTIVE
  To analyze the association of the different genotypes of TaqI polymorphism of the VDR gene with BMD in young Mexican women.
  
  
  METHODS
  Dual X-ray absorptiometry was carried out in 150 women aged 19 to 29 years in order to determine their total bone mineral density (tBMD) and dual BMD of the femur (dfBMD). DNA was extracted from peripheral blood to determine the genotype of the TaqI polymorphism in the VDR gene. The data obtained were analyzed by simple linear regression and ANOVA.
  
  
  RESULTS
  Mean tBMD was 1.096 ± 0.064 mean dfBMD was 0.960 ± 0.107 g/cm². The frequency of the TaqI polymorphisms was 57% (TT), 37% (Tt) and 6% (tt), the frequency of the alleles was 75% (T) and 25% (t). Ths statistical analysis showed a lack of association between BMD and the genotypes of TaqI polymorphism in the VDR gene.
  
  
  CONCLUSIONS
  These results suggest that may exist factors other than the TaqI polymorphism in the VDR gene contributing to BMD in young women from Northern Mexico.
authors.affiliation: Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors.forename: Z
authors.initials: Z
authors.lastname: Jiménez-Salas
authors.forename: E A
authors.initials: EA
authors.lastname: Hernández-Tobías
authors.forename: T E
authors.initials: TE
authors.lastname: Ramírez-López
authors.forename: E
authors.initials: E
authors.lastname: Campos-Góngora
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015519:Bone Density / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics / Q000502:physiology; D018167:Receptors, Calcitriol / Q000235:genetics*; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D018167:Receptors, Calcitriol; D004247:DNA; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases