title: Synthesis of indolizines and heterocyclic chalcones catalyzed by supported copper nanoparticles.
abstract: Solvent decides: Versatile copper nanoparticles (Cu NPs) on activated carbon have been found to catalyze the multicomponent synthesis of indolizines in dichloromethane and the synthesis of heterocyclic chalcones in the absence of solvent, in both cases, from pyridine-2-carbaldehyde derivatives, secondary amines, and terminal alkynes (see scheme).
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Albaladejo
authors.forename: Francisco
authors.initials: F
authors.lastname: Alonso
authors.forename: Miguel
authors.initials: M
authors.lastname: Yus
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000588:Amines; D047188:Chalcones; D006571:Heterocyclic Compounds; D007212:Indolizines; D011725:Pyridines; C432864:pyridine-2-carbaldehyde; D003300:Copper