title: Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.
abstract: Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM.
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, 151-747 Seoul, Republic of Korea.
authors.forename: Dongyup
authors.initials: D
authors.lastname: Hahn
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Won
authors.forename: Bora
authors.initials: B
authors.lastname: Mun
authors.forename: Hiyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Chulkyeong
authors.initials: C
authors.lastname: Han
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.forename: Taeho
authors.initials: T
authors.lastname: Chun
authors.forename: Sunhee
authors.initials: S
authors.lastname: Park
authors.forename: Dajeong
authors.initials: D
authors.lastname: Yoon
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.forename: Merrick
authors.initials: M
authors.lastname: Ekins
authors.forename: Jungwook
authors.initials: J
authors.lastname: Chin
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D000882:Haplorhini; D006801:Humans; D020014:K562 Cells; D007680:Kidney Neoplasms / Q000188:drug therapy; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D000970:Antineoplastic Agents; D054830:Sesterterpenes