title: Pyridone alkaloids from a marine-derived fungus, Stagonosporopsis cucurbitacearum, and their activities against azole-resistant Candida albicans.
abstract: Four new 4-hydroxy-2-pyridone alkaloids, didymellamides A-D (1-4), were isolated from the marine-derived fungus Stagonosporopsis cucurbitacearum. The structures of 1-4 were elucidated from spectroscopic data (NMR, MS, and IR), and the absolute configuration of 1 was determined by X-ray diffraction analysis. Didymellamide A (1) exhibited antifungal activity against azole-resistant Candida albicans.
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
authors.forename: Asami
authors.initials: A
authors.lastname: Haga
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tamoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ishino
authors.forename: Eriko
authors.initials: E
authors.lastname: Kimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugita
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Kunio
authors.initials: K
authors.lastname: Takahashi
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Koyama
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents; D001393:Azoles; D011728:Pyridones