title: A ~60-min brisk walk increases insulin-stimulated glucose disposal but has no effect on hepatic and adipose tissue insulin sensitivity in older women.
abstract: The purpose of this study was to determine whether brisk walking improves multiorgan (liver, muscle, adipose tissue) insulin sensitivity in older women. Ten nonobese older women (age: 66.7 ± 1.5 yr, mean ± SE) completed two 2-stage hyperinsulinemic-euglycemic clamp procedures [insulin infusion rate stage 1: 10 mU/m(2) body surface area (BSA) per min; stage 2: 50 mU/m(2) BSA per min] in conjunction with stable isotope-labeled glucose and palmitate tracer infusions: one in the morning after a single, ∼1-h bout of brisk treadmill walking, the other after an equivalent period of rest in the late afternoon of the preceding day. We found that basal glucose rate of appearance (Ra) into plasma was not different after rest and after exercise (17.3 ± 0.8 and 17.1 ± 0.4 μmol/kg fat-free mass per min, respectively). The insulin-mediated decrease in glucose Ra during stage 1 of the clamp was also not different after rest and exercise (82.2% ± 3.4% and 77.7% ± 2.1%, respectively), but glucose rate of disappearance (Rd) during stage 2 of the clamp was significantly greater (P < 0.05) after exercise than rest (88.0 ± 5.9 and 78.4 ± 6.5 μmol/kg fat-free mass per min, respectively). There were no differences in palmitate Ra during basal conditions or insulin infusion after exercise and after rest. Therefore, we conclude that a single bout of brisk walking for ∼1 h improves muscle insulin sensitivity but has no effect on liver and adipose tissue insulin sensitivity in older women.
authors.affiliation: Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, Missouri, USA. xwang@sc.edu
authors.forename: Xuewen
authors.initials: X
authors.lastname: Wang
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Patterson
authors.forename: Gordon I
authors.initials: GI
authors.lastname: Smith
authors.forename: Janine
authors.initials: J
authors.lastname: Kampelman
authors.forename: Dominic N
authors.initials: DN
authors.lastname: Reeds
authors.forename: Shelby A
authors.initials: SA
authors.lastname: Sullivan
authors.forename: Bettina
authors.initials: B
authors.lastname: Mittendorfer
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D018482:Muscle, Skeletal / Q000502:physiology*; D010807:Physical Endurance / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology; D016138:Walking / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: exercise; insulin sensitivity; older adults