title: Effects of Peripheral and Intra-hippocampal Administration of Sodium Salicylate on Spatial Learning and Memory of Rats.
abstract: OBJECTIVE
  Cyclooxygenases (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since sodium salicylate is an inhibitor of COX, we have evaluated the effect of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory in male rats.
  
  
  METHODS
  Male rats were studied in two groups; the first group received different intraperitoneal (i.p.) sodium salicylate doses (0, 200, 300, and 400 mg/kg) and the second group received intra-hippocampal doses of the drug (0, 30, 50, and 100 μg/0.5 μl/side). The spatial performance of rats was tested using Morris water maze (MWM) task. The spatial learning and memory parameters were analyzed using ANOVA.
  
  
  RESULTS
  Peripheral and intra-hippocampal administration of sodium salicylate did not lead to a statistically significant change in the mean time (escape latency), and also the distance traveled for finding the hidden platform during the training days, compared with the control group. But at the probe trial, the percentage of time spent in the target quadrant by rats which received the highest doses of drug significantly increased.
  
  
  CONCLUSIONS
  We found that both peripheral and intra-hippocampal administration of sodium salicylate facilitates the process of spatial memory consolidation in the MWM.
authors.affiliation: Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran ; Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Azimi
authors.forename: Ali
authors.initials: A
authors.lastname: Pourmotabbed
authors.forename: Mohammad Rasool
authors.initials: MR
authors.lastname: Ghadami
authors.forename: Seyed Ershad
authors.initials: SE
authors.lastname: Nedaei
authors.forename: Targol
authors.initials: T
authors.lastname: Pourmotabbed
keywords: Cyclooxygenase; Rat; Sodium salicylate; Spatial memory