title: Nicotinic acid conjugates of nonsteroidal anti-inflammatory drugs (NSAID's) and their anti-inflammatory properties.
abstract: A series of nicotinic acid conjugates with non-steroidal anti-inflammatory drugs (NSAID's) have been effectively synthesized using TBTU in high yield and purity. All the synthesized conjugates were evaluated for their in vitro anti-inflammatory activity.
authors.affiliation: Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT-University, Vellore 632 014, Tamil Nadu, India.
authors.forename: Machhindra
authors.initials: M
authors.lastname: Gund
authors.forename: Fazlur-Rahman Nawaz
authors.initials: FR
authors.lastname: Khan
authors.forename: Amit
authors.initials: A
authors.lastname: Khanna
authors.forename: Varadhan
authors.initials: V
authors.lastname: Krishnakumar
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D009525:Niacin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D009525:Niacin