title: Structural Biology of a Major Signaling Network that Regulates Plant Abiotic Stress: The CBL-CIPK Mediated Pathway.
abstract: The Arabidopsis SOS2 family of twenty-six protein kinases (CIPKs), their interacting activators, the SOS3 family of ten calcium-binding proteins (CBLs) and protein phosphatases type 2C (PP2C), function together in decoding calcium signals elicited by different environmental stimuli. Biochemical data suggest that stable CBL-CIPK or CIPK-PP2C complexes may be regulating the activity of various substrates controlling ion homeostasis. The available structural information provides a general regulatory mechanism in which calcium perception by CBLs and kinase activation is coupled. The structural basis of this molecular mechanism and the specificity of the network is reviewed and discussed in detail.
authors.affiliation: Department of Crystallography and Structural Biology, Instituto de Química Física "Rocasolano", Consejo Superior de Investigaciones Científicas, Serrano 119, Madrid E-28006, Spain. xalbert@iqfr.csic.es.
authors.forename: María José
authors.initials: MJ
authors.lastname: Sánchez-Barrena
authors.forename: Martín
authors.initials: M
authors.lastname: Martínez-Ripoll
authors.forename: Armando
authors.initials: A
authors.lastname: Albert