title: Adenosine A2A receptor antagonist istradefylline reduces daily OFF time in Parkinson's disease.
abstract: BACKGROUND
  We evaluated the efficacy and safety of istradefylline, a selective adenosine A2A receptor antagonist administered as adjunctive treatment to levodopa for 12 weeks in a double-blind manner in Parkinson's disease patients with motor complications in Japan.
  
  
  METHODS
  A total of 373 subjects were randomized to receive placebo (n=126), istradefylline 20 mg/day (n=123), or istradefylline 40 mg/day (n=124). The primary efficacy variable was the change in daily OFF time. Other secondary variables were also evaluated.
  
  
  RESULTS
  The change in daily OFF time was significantly reduced in the istradefylline 20 mg/day (-0.99 hours, P=.003) and istradefylline 40 mg/day (-0.96 hours, P=.003) groups compared with the placebo group (-0.23 hours). The most common adverse event was dyskinesia (placebo, 4.0%; istradefylline 20 mg/day, 13.0%; istradefylline 40 mg/day, 12.1%).
  
  
  CONCLUSIONS
  Istradefylline reduced daily OFF time and was well tolerated in Japanese PD patients with motor complications on levodopa treatment.
authors.affiliation: Kitasato University School of Medicine, Kanagawa, Japan. y_mizuno@juntendo.ac.jp
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Kondo
mesh_terms: D058917:Adenosine A2 Receptor Antagonists / Q000627:therapeutic use*; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D011687:Purines / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D058917:Adenosine A2 Receptor Antagonists; D011687:Purines; C111599:istradefylline
keywords: Parkinson's disease; istradefylline; levodopa; motor complications; wearing-off