title: Coronary slow flow and abnormal nocturnal blood pressure profile in normotensives.
abstract: BACKGROUND
  Abnormal nocturnal blood pressure (BP) profile has been linked to microvascular function and autonomic dysfunction. However, no data were available regarding nocturnal BP profile in coronary slow flow (CSF).
  
  
  OBJECTIVE
  The aim was to investigate any association between CSF and abnormal BP response in normotensive patients.
  
  
  METHODS
  Consecutive 45 patients with CSF and 45 patients with normal blood flow during coronary angiography underwent 24-hour ambulatory BP monitoring. Hemodynamic parameters including 24-hour, daytime and nighttime systolic/diastolic/mean/pulse pressures, and BP % changes were obtained. Dippers, nondippers, and reverse dippers were determined.
  
  
  RESULTS
  Baseline characteristics of both groups were well matched except for TIMI (Thrombosis in Myocardial Infarction) frame counts for all major epicardial coronary arteries. No statistical significance was detected regarding to hemodynamic parameters obtained by 24-hour ambulatory BP monitoring. The prevalence of nondippers was higher in CSF patients compared with controls (51.1% vs 28.9%, respectively). In univariate analysis, systolic BP change (%), 24-hour diastolic BP, diastolic BP change (%), 24-hour mean BP, mean BP change (%), nondipper/reverse dipper, and separately nondipper status were found to be significant predictors for CSF. However, in multivariate logistic regression analysis, systolic BP change (%) (odds ratio [OR], 0.934; 95% confidence interval [CI], 0.874-0.998; P = 0.045), nondipper/reverse dipper status (OR, 0.505; 95% CI, 0.265-0.962; P = 0.038), and separately nondipper status (OR, 0.317; 95% CI, 0.126-0.797; P = 0.015) were found to be significant predictors for CSF.
  
  
  CONCLUSIONS
  The frequency of nondippers was higher in slow flow, and there was a significant association between CSF and abnormal nocturnal BP profile in normotensives.
authors.affiliation: Faculty of Medicine, Department of Cardiology, Yildirim Beyazit University, Ankara, Turkey. drtdurmaz@hotmail.com
authors.forename: Tahir
authors.initials: T
authors.lastname: Durmaz
authors.forename: Telat
authors.initials: T
authors.lastname: Keles
authors.forename: Kemal Esref
authors.initials: KE
authors.lastname: Erdogan
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ayhan
authors.forename: Emine
authors.initials: E
authors.lastname: Bilen
authors.forename: Murat
authors.initials: M
authors.lastname: Akcay
authors.forename: Nihal Akar
authors.initials: NA
authors.lastname: Bayram
authors.forename: Serdal
authors.initials: S
authors.lastname: Bastug
authors.forename: Engin
authors.initials: E
authors.lastname: Bozkurt
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D003326:Coronary Circulation / Q000502:physiology*; D003710:Demography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D054318:No-Reflow Phenomenon / Q000503:physiopathology*; D016017:Odds Ratio; D013599:Systole / Q000502:physiology