title: Are troponin assays occasionally deceiving us?
abstract: Troponin (I or T) is the principal marker of myocardial injury used in clinical practice. Although immune-based methods to determine troponin I levels are generally reliable, the presence of human antibodies interfering with the assays components could lead to erroneous results. In this report, we will discuss the case of a patient with misleadingly elevated troponin I due to high rheumatoid factor titer and provide an insight into the responsible molecular mechanisms.
authors.affiliation: Department of Internal Medicine, Volos General Hospital, 38222 Volos, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Ntelios
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Mpei
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Gousi
authors.forename: Evangelos
authors.initials: E
authors.lastname: Potolidis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Fanourgiakis
authors.forename: Charalampos
authors.initials: C
authors.lastname: Mandros
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood; D005189:False Positive Reactions; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood; D012217:Rheumatoid Factor / Q000097:blood / Q000276:immunology; D019210:Troponin I / Q000097:blood* / Q000276:immunology
chemical_list: D019210:Troponin I; D012217:Rheumatoid Factor