title: A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction.
abstract: Patients with opioid addiction who receive prescription opioids for treatment of nonmalignant chronic pain present a therapeutic challenge. Fifty-four participants with chronic pain and opioid addiction were randomized to receive methadone or buprenorphine/naloxone. At the 6-month follow-up examination, 26 (48.1%) participants who remained in the study noted a 12.75% reduction in pain (P = 0.043), and no participants in the methadone group compared to 5 in the buprenorphine group reported illicit opioid use (P = 0.039). Other differences between the two conditions were not found. Long-term, low-dose methadone or buprenorphine/naloxone treatment produced analgesia in participants with chronic pain and opioid addiction.
authors.affiliation: Primary Care Research Institute, Department of Family Medicine, State University of New York at Buffalo, Buffalo, New York, USA.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Neumann
authors.forename: Richard D
authors.initials: RD
authors.lastname: Blondell
authors.forename: Urmo
authors.initials: U
authors.lastname: Jaanimägi
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Giambrone
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Homish
authors.forename: Jacqueline R
authors.initials: JR
authors.lastname: Lozano
authors.forename: Urszula
authors.initials: U
authors.lastname: Kowalik
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Azadfard
mesh_terms: D000286:Administration, Sublingual; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use* / Q000652:urine; D000704:Analysis of Variance; D002047:Buprenorphine / Q000008:administration & dosage / Q000627:therapeutic use*; D059350:Chronic Pain / Q000150:complications / Q000188:drug therapy*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009270:Naloxone / Q000008:administration & dosage / Q000627:therapeutic use; D009293:Opioid-Related Disorders / Q000150:complications / Q000188:drug therapy* / Q000652:urine; D063487:Prescription Drug Misuse; D012720:Severity of Illness Index; D015813:Substance Abuse Detection; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D004338:Drug Combinations; D009270:Naloxone; D002047:Buprenorphine; D008691:Methadone