title: Multifunctional mesoporous silica-coated graphene nanosheet used for chemo-photothermal synergistic targeted therapy of glioma.
abstract: Current therapy of malignant glioma in clinic is unsatisfactory with poor patient compliance due to low therapeutic efficiency and strong systemic side effects. Herein, we combined chemo-photothermal targeted therapy of glioma within one novel multifunctional drug delivery system. A targeting peptide (IP)-modified mesoporous silica-coated graphene nanosheet (GSPI) was successfully synthesized and characterized, and first introduced to the drug delivery field. A doxorubicin (DOX)-loaded GSPI-based system (GSPID) showed heat-stimulative, pH-responsive, and sustained release properties. Cytotoxicity experiments demonstrated that combined therapy mediated the highest rate of death of glioma cells compared to that of single chemotherapy or photothermal therapy. Furthermore, the IP modification could significantly enhance the accumulation of GSPID within glioma cells. These findings provided an excellent drug delivery system for combined therapy of glioma due to the advanced chemo-photothermal synergistic targeted therapy and good drug release properties of GSPID, which could effectively avoid frequent and invasive dosing and improve patient compliance.
authors.affiliation: Center of Analysis and Measurement, Fudan University, Shanghai 200433, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Kaiyuan
authors.initials: K
authors.lastname: Wang
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhao
authors.forename: Xingang
authors.initials: X
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Bu
authors.forename: Xueying
authors.initials: X
authors.lastname: Yan
authors.forename: Rongqin
authors.initials: R
authors.lastname: Huang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced; D049329:Nanostructures / Q000737:chemistry; D055668:Photochemical Processes; D010778:Photochemotherapy; D011522:Protons; D012822:Silicon Dioxide / Q000737:chemistry*; D013696:Temperature
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D011522:Protons; D012822:Silicon Dioxide; D006108:Graphite; D004317:Doxorubicin