title: Functions of the centromere and kinetochore in chromosome segregation.
abstract: Centromeres play essential roles in equal chromosome segregation by directing the assembly of the microtubule binding kinetochore and serving as the cohesion site between sister chromatids. Here, we review the significant recent progress in our understanding of centromere protein assembly and how centromere proteins form the foundation of the kinetochore.
authors.affiliation: Department of Biochemistry, Stanford University Medical School, Stanford, CA 94305, United States.
authors.forename: Frederick G
authors.initials: FG
authors.lastname: Westhorpe
authors.forename: Aaron F
authors.initials: AF
authors.lastname: Straight
mesh_terms: D000818:Animals; D002503:Centromere / Q000378:metabolism*; D002842:Chromatids / Q000378:metabolism; D020090:Chromosome Segregation; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D011485:Protein Binding
chemical_list: D004268:DNA-Binding Proteins