title: Cytotoxic effects of secosterols and their derivatives on several cultured cells.
abstract: The cytotoxic effects of various oxysterols on several culture cells were examined. Ozonolysis products of cholesterol, secosterols (3β-hydroxy-5-oxo-5,6-secocholestan-6-al) and its aldolization product (3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde) and their keto alcohol and acid derivatives, were found to have potent cytotoxic activities, as compared with major endogenous oxysterols such as 5β,6β-epoxycholesterol, 7β-hydroxycholesterol, 7-ketocholesterol, and 25-hydroxycholesterol. Secosterols might play important roles in tissue damage and inflammation-associated diseases.
authors.affiliation: Laboratory of Biochemistry, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, Graduate Program in Food and Nutritional Sciences, University of Shizuoka, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Tomono
authors.forename: Yukari
authors.initials: Y
authors.lastname: Yasue
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Miyoshi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohshima
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002778:Cholestanones / Q000737:chemistry* / Q000633:toxicity*; D003603:Cytotoxins / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D012632:Secosteroids / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D002778:Cholestanones; D003603:Cytotoxins; D012632:Secosteroids; C082684:3-hydroxy-5-oxo-5,6-secocholestan-6-al