title: Structure, mechanical properties, corrosion behavior and cytotoxicity of biodegradable Mg-X (X=Sn, Ga, In) alloys.
abstract: As-cast Mg-Sn, Mg-Ga and Mg-In alloys containing 1-7 wt.% of alloying elements were studied in this work. Structural and chemical analysis of the alloys was performed by using light and scanning electron microscopy, energy dispersive spectrometry, x-ray diffraction, x-ray photoelectron spectroscopy and glow discharge spectrometry. Mechanical properties were determined by Vickers hardness measurements and tensile testing. Corrosion behavior in a simulated physiological solution (9 g/l NaCl) was studied by immersion tests and potentiodynamic measurements. The cytotoxicity effect of the alloys on human osteosarcoma cells (U-2 OS) was determined by an indirect contact assay. Structural investigation revealed the dendritic morphology of the as-cast alloys with the presence of secondary eutectic phases in the Mg-Sn and Mg-Ga alloys. All the alloying elements showed hardening and strengthening effects on magnesium. This effect was the most pronounced in the case of Ga. All the alloying elements at low concentrations of approximately 1 wt.% were also shown to positively affect the corrosion resistance of Mg. But at higher concentrations of Ga and Sn the corrosion resistance worsened due to galvanic effects of secondary phases. Cytotoxicity tests indicated that Ga had the lowest toxicity, followed by Sn. The most severe toxicity was observed in the case of In.
authors.affiliation: Department of Metals and Corrosion Engineering, Institute of Chemical Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. Jiri.Kubasek@vscht.cz
authors.forename: J
authors.initials: J
authors.lastname: Kubásek
authors.forename: D
authors.initials: D
authors.lastname: Vojtěch
authors.forename: J
authors.initials: J
authors.lastname: Lipov
authors.forename: T
authors.initials: T
authors.lastname: Ruml
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D003343:Corrosion; D006801:Humans; D008422:Materials Testing; D055595:Mechanical Phenomena / Q000187:drug effects*; D008670:Metals / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D056951:Photoelectron Spectroscopy; D011199:Potentiometry; D013718:Tensile Strength / Q000187:drug effects
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D008670:Metals