title: Effects of pancragen on the differentiation of pancreatic cells during their ageing.
abstract: Expression of differentiation markers was found to be reduced during ageing of pancreatic cells. Tetrapeptide pancragen stimulates the expression of differentiation factors of acinar (Pdx1, Ptfla) and islet of Langerhans (Pdx1, Pax6, Pax4, Foxa2, NKx2.2) cells in "young" and " aged" cultures. Differentiation of acinar and islet pancreatic cells induced by pancragen can be a mechanism underlying its anti-diabetic and anti-inflammatory effects. Thus, transcription factors that regulate differentiation of pancreatic cells are a pharmacological target for pancragen, which allows considering it as an effective tool in the treatment of diabetes mellitus and pancreatitis.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: A O
authors.initials: AO
authors.lastname: Durnova
authors.forename: V O
authors.initials: VO
authors.lastname: Polyakova
authors.forename: G H
authors.initials: GH
authors.lastname: Tolibova
authors.forename: N S
authors.initials: NS
authors.lastname: Linkova
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoy
authors.forename: T V
authors.initials: TV
authors.lastname: Kvetnaia
authors.forename: S I
authors.initials: SI
authors.lastname: Tarnovskaya
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D016922:Cellular Senescence / Q000187:drug effects; D000090322:Homeobox Protein Nkx-2.2; D018398:Homeodomain Proteins; D006801:Humans; D009687:Nuclear Proteins; D009842:Oligopeptides / Q000494:pharmacology*; D010179:Pancreas / Q000166:cytology*; D014157:Transcription Factors
chemical_list: D000090322:Homeobox Protein Nkx-2.2; D018398:Homeodomain Proteins; C000715631:NKX2-2 protein, human; D009687:Nuclear Proteins; D009842:Oligopeptides; D014157:Transcription Factors; C531938:lysyl-glutamyl-aspartyl-tryptophanamide