title: Primary motor cortex hyperexcitability in Fabry's disease.
abstract: OBJECTIVE
  Involvement of pyramidal cells and/or changes in excitability of brain areas remote from an ischemic stroke has been demonstrated. Since in Fabry disease (FD), specific cerebrovascular lesions are present, we thought to investigate motor cortex excitability, using transcranial magnetic stimulation.
  
  
  METHODS
  Resting (RMT) and active (AMT) motor threshold, input-output curve (IN-OUT), central motor conduction time (CMCT), cortical silent period (cSP), short and long interval intracortical inhibition (SICI and LICI), intracortical facilitation (ICF), short interval intracortical facilitation (SICF) and short afferent inhibition (SAI) were measured in the cortical representation of the right first dorsal interosseous muscle in 11 patients with FD and 11 sex- and age matched healthy subjects.
  
  
  RESULTS
  FD patients showed a significant increase of steepness in IN-OUT, ICF and SICF curves. RMT, AMT, CMCT, SICI, LICI and SAI were normal.
  
  
  CONCLUSIONS
  Our data documented an increased activity of motor cortex glutamatergic excitatory circuits in FD, evident also in patients without brain MRI lesions. Following enzyme replacement treatment, this abnormality was partly reversed.
  
  
  CONCLUSIONS
  We suggest that our findings are expression of subtle "biochemical brain lesions", due to an early involvement of neurons and/or astrocytes by the cascade of pathologic events leading to brain damage in FD.
authors.affiliation: Neurology Unit, A. Segni Hospital, ASL 1 Sassari, via Colle Cappuccini, 07014 Ozieri (SS), Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Ortu
authors.forename: Laura
authors.initials: L
authors.lastname: Fancellu
authors.forename: GianFranco
authors.initials: G
authors.lastname: Sau
authors.forename: Paolo
authors.initials: P
authors.lastname: Falchi
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Traccis
authors.forename: Giovanni Mario
authors.initials: GM
authors.lastname: Pes
authors.forename: Antonello
authors.initials: A
authors.lastname: Ganau
authors.forename: Gianpietro
authors.initials: G
authors.lastname: Sechi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001703:Biophysics; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D000795:Fabry Disease / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D012146:Rest; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult