title: Activities of first-choice antimicrobials against gamma interferon-treated Chlamydia trachomatis differ in hypoxia.
abstract: Gamma interferon (IFN-γ)-mediated host responses play a central role in resolving genital Chlamydia trachomatis infections but may also result in persistence of the pathogen, which shows reduced susceptibility to antimicrobials. The antichlamydial function of IFN-γ is oxygen dependent, and the efficacy of antimicrobials against C. trachomatis is reduced in a low-oxygen environment. In this study, we show that the antichlamydial efficacies of azithromycin and doxycycline differ in IFN-γ-treated cells under hypoxia.
authors.affiliation: Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, Germany.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Shima
authors.forename: Matthias
authors.initials: M
authors.lastname: Klinger
authors.forename: Werner
authors.initials: W
authors.lastname: Solbach
authors.forename: Jan
authors.initials: J
authors.lastname: Rupp
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017963:Azithromycin / Q000494:pharmacology* / Q000627:therapeutic use; D015687:Cell Hypoxia; D002690:Chlamydia Infections / Q000188:drug therapy / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000187:drug effects*; D004318:Doxycycline / Q000494:pharmacology* / Q000627:therapeutic use; D006367:HeLa Cells / Q000187:drug effects / Q000382:microbiology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology* / Q000627:therapeutic use; D010100:Oxygen / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D007371:Interferon-gamma; D017963:Azithromycin; D004318:Doxycycline; D010100:Oxygen