title: A case of male invasive breast carcinoma presenting as a non-healing wound.
abstract: Breast cancer in male patients accounts for less than 1 percent of malignancies in men. When compared to women, men with breast cancer are, on average, older, diagnosed at a more advanced stage, more likely to be hormone-receptor positive, less likely to overexpress HER2/neu, and have a lower overall survival. Owing to the paucity of data, male breast cancer treatment is typically guided by trials from female breast cancer. We report a case of invasive ductal carcinoma in a male patient with the initial presenting morphology of a non-healing chest wound. Interestingly, immunostaining identified positivity for estrogen receptor, progesterone receptor, and HER2/neu in the patients tumor. Although rare, breast carcinoma is an important consideration in any male with a breast mass, retracted nipple, or ulceration, as was seen in our patient.
authors.affiliation: University of Illinois at Chicago, Department of Dermatology, Chicago, Illinois, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Cooper
authors.forename: Adrienne
authors.initials: A
authors.lastname: Schupbach
authors.forename: Lawrence
authors.initials: L
authors.lastname: Chan
mesh_terms: D000328:Adult; D018567:Breast Neoplasms, Male / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D006801:Humans; D008297:Male; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D014945:Wound Healing / Q000502:physiology
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone