title: Vinculin, cell mechanics and tumour cell invasion.
abstract: The focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, and discusses implications for a role of vinculin in promoting cancer cell migration in 3D environments.
authors.affiliation: Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, Germany. wgoldmann@biomed.uni-erlangen.de
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Goldmann
authors.forename: Vera
authors.initials: V
authors.lastname: Auernheimer
authors.forename: Ingo
authors.initials: I
authors.lastname: Thievessen
authors.forename: Ben
authors.initials: B
authors.lastname: Fabry
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D063646:Carcinogenesis; D002448:Cell Adhesion; D002465:Cell Movement; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D016596:Vinculin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000199:Actins; D016596:Vinculin