title: Tumor indicating normal tissue could be a new source of diagnostic and prognostic markers for prostate cancer.
abstract: BACKGROUND
  Prostate cancer is a common and multifocal disease but the diagnostic methods available are unsatisfactory. Most tumors present are of low malignant potential, whereas others are highly aggressive. At present, imaging cannot be used to guide tissue biopsies safely towards the most aggressive tumor present. To handle this problem multiple needle biopsies are taken. The biopsies often contain only normal prostate tissue, and even if the tumor is sampled it is not known whether a more aggressive cancer is present elsewhere in the organ. If changes in the normal tissue indicate the presence and nature of tumors, this information could be used to improve diagnostics and prognostics of prostate cancer.
  
  
  METHODS
  Current evidence that the tumor-adjacent morphologically normal prostate tissue is not completely normal is reviewed, and that this tissue, named tumor indicating normal tissue (TINT) by the authors, can be used to diagnose prostate cancer.
  
  
  RESULTS
  The reader will understand that tumors need to affect their surroundings in order to grow and metastasize and that the normal prostate tissue is therefore tinted by the presence and nature of cancer and that this knowledge can be used to develop new diagnostic and prognostic markers.
  
  
  CONCLUSIONS
  TINT changes could probably, when more rigorously defined and validated, be used to diagnose and prognosticate prostate cancer.
authors.affiliation: Umeå University, Department of Medical Biosciences, Pathology, Building 6M, Second Floor, S-90187 Umeå, Sweden +46 90 785 15 30 ; +46 90 785 44 84 ; anders.bergh@medbio.umu.se.
authors.forename: Sofia
authors.initials: S
authors.lastname: Halin
authors.forename: Peter
authors.initials: P
authors.lastname: Hammarsten
authors.forename: Hani
authors.initials: H
authors.lastname: Adamo
authors.forename: Pernilla
authors.initials: P
authors.lastname: Wikström
authors.forename: Anders
authors.initials: A
authors.lastname: Bergh