title: A new approach to classification of disease severity and progression of COPD.
abstract: BACKGROUND
  Most current classification schemes for COPD use lung function as the primary way of classifying disease severity and monitoring disease progression. This approach misses important components of the disease process.
  
  
  METHODS
  We evaluated existing data to develop a classification scheme for COPD using measures beyond lung function, including respiratory symptoms, exacerbation history, quality-of-life assessment, comorbidity, and BMI. We then applied this scheme to data from the Lung Health Study, calculating a score for study subjects in year 1 and year 5 of the study, along with the difference between year 1 and year 5.
  
  
  RESULTS
  We developed a four-point scale ranging from 1.00 (mild) to 4.00 (very severe). In year 1 of the study, the mean COPD score was 1.76; in year 5 it was 1.82. The mean difference from year 1 to year 5 was an increase (worsening) of 0.06 and a range from -1.0 to 1.6. The COPD score at year 1, year 5, and the difference between these scores were all predictive of mortality at follow-up. For example, the 14.0% of subjects whose score improved by at least 0.25 between year 1 and 5 had decreased mortality compared with those with stable scores (between -0.25 and 0.25; hazard ratio, 0.6; 95% CI, 0.4, 0.8).
  
  
  CONCLUSIONS
  A COPD severity score that includes components in addition to lung function and allows for both improvement and worsening of disease may provide additional guidance to COPD classification, management, and prognosis.
authors.affiliation: Department of Preventive Medicine and Environmental Health, College of Medicine, University of Kentucky, Lexington, KY; College of Public Health and Division of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Kentucky, Lexington, KY. Electronic address: dmannino@uky.edu.
authors.forename: David M
authors.initials: DM
authors.lastname: Mannino
authors.affiliation: College of Public Health and Division of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Kentucky, Lexington, KY.
authors.forename: Enrique
authors.initials: E
authors.lastname: Diaz-Guzman
authors.affiliation: Department of Preventive Medicine and Environmental Health, College of Medicine, University of Kentucky, Lexington, KY.
authors.forename: John
authors.initials: J
authors.lastname: Pospisil
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000145:classification*; D012720:Severity of Illness Index