title: Preliminary specificity study of the Bestel-Clément-Sorine electromechanical model of the heart using parameter calibration from medical images.
abstract: Patient-specific cardiac modelling can help in understanding pathophysiology and predict therapy effects. This requires the personalization of the geometry, kinematics, electrophysiology and mechanics. We use the Bestel-Clément-Sorine (BCS) electromechanical model of the heart, which provides reasonable accuracy with a reduced parameter number compared to the available clinical data at the organ level. We propose a preliminary specificity study to determine the relevant global parameters able to differentiate the pathological cases from the healthy controls. To this end, a calibration algorithm on global measurements is developed. This calibration method was tested successfully on 6 volunteers and 2 heart failure cases and enabled to tune up to 7 out of the 14 necessary parameters of the BCS model, from the volume and pressure curves. This specificity study confirmed domain-knowledge that the relaxation rate is impaired in post-myocardial infarction heart failure and the myocardial stiffness is increased in dilated cardiomyopathy heart failures.
authors.affiliation: INRIA, Asclepios Research Project, Sophia Antipolis, France. stephanie.marchesseau@inria.fr
authors.forename: S
authors.initials: S
authors.lastname: Marchesseau
authors.forename: H
authors.initials: H
authors.lastname: Delingette
authors.forename: M
authors.initials: M
authors.lastname: Sermesant
authors.forename: M
authors.initials: M
authors.lastname: Sorine
authors.forename: K
authors.initials: K
authors.lastname: Rhode
authors.forename: S G
authors.initials: SG
authors.lastname: Duckett
authors.forename: C A
authors.initials: CA
authors.lastname: Rinaldi
authors.forename: R
authors.initials: R
authors.lastname: Razavi
authors.forename: N
authors.initials: N
authors.lastname: Ayache
mesh_terms: D000465:Algorithms; D002138:Calibration; D003198:Computer Simulation; D006329:Heart Conduction System / Q000503:physiopathology*; D006331:Heart Diseases / Q000503:physiopathology*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology*; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity