title: The role of Hispanic ethnicity in pediatric Wilms' tumor survival.
abstract: Wilms' tumors (WT) constitute approximately 6-14% of all childhood cancers and about 95% of all pediatric renal malignancies. While prognostic factors for this malignancy are relatively well-defined, few studies have specifically examined the role of Hispanic ethnicity in pediatric WT survival. The purpose of this study was to compare WT survival among non-Hispanic white (NHW), non-Hispanic black (NHB), and Hispanic cases using data from the Surveillance, Epidemiology, and End Results (SEER) program. WT cases (ICD-O-3 histological code 8960) under age 20 were isolated from a recent subset of the SEER dataset (1990-2009). Demographics and tumor characteristics were compared by race/ethnicity, and 5- and 10-year survival probabilities were calculated. Multivariable Cox proportional hazards regression was used to assess the effects of race/ethnicity on WT survival, adjusting for relevant covariates. Hispanic ethnicity was significantly associated with WT-specific mortality hazard, controlling for age, sex, diagnosis/treatment era, laterality, SEER stage, cancer-directed surgery, and radiation therapy (HR: 1.52, 95% CI: 1.02-2.25). The results of this study suggest that Hispanic pediatric WT cases may have a higher risk of WT-related death, compared to NHW cases. Additional research on racial/ethnic disparities in WT survival is warranted.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Dan L Duncan Cancer Center, One Baylor Plaza, Houston, TX 77030, USA. amirian@bcm.edu
authors.forename: E Susan
authors.initials: ES
authors.lastname: Amirian
mesh_terms: D000293:Adolescent; D044383:Black People; D002648:Child; D002675:Child, Preschool; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000208:ethnology* / Q000401:mortality; D008297:Male; D016016:Proportional Hazards Models; D044465:White People; D009396:Wilms Tumor / Q000208:ethnology* / Q000401:mortality