title: Resting-state functional connectivity predicts impulsivity in economic decision-making.
abstract: Increasing neuroimaging evidence suggests an association between impulsive decision-making behavior and task-related brain activity. However, the relationship between impulsivity in decision-making and resting-state brain activity remains unknown. To address this issue, we used functional MRI to record brain activity from human adults during a resting state and during a delay discounting task (DDT) that requires choosing between an immediate smaller reward and a larger delayed reward. In experiment I, we identified four DDT-related brain networks. The money network (the striatum, posterior cingulate cortex, etc.) and the time network (the medial and dorsolateral prefrontal cortices, etc.) were associated with the valuation process; the frontoparietal network and the dorsal anterior cingulate cortex-anterior insular cortex network were related to the choice process. Moreover, we found that the resting-state functional connectivity of the brain regions in these networks was significantly correlated with participants' discounting rate, a behavioral index of impulsivity during the DDT. In experiment II, we tested an independent group of subjects and demonstrated that this resting-state functional connectivity was able to predict individuals' discounting rates. Together, these findings suggest that resting-state functional organization of the human brain may be a biomarker of impulsivity and can predict economic decision-making behavior.
authors.affiliation: Chinese Academy of Sciences, Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiao-Song
authors.initials: XS
authors.lastname: He
authors.forename: De-Lin
authors.initials: DL
authors.lastname: Sun
authors.forename: Xian-Ming
authors.initials: XM
authors.lastname: Fu
authors.forename: Xiaochu
authors.initials: X
authors.lastname: Zhang
authors.forename: Shihui
authors.initials: S
authors.lastname: Han
authors.forename: Da-Ren
authors.initials: DR
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D003657:Decision Making / Q000502:physiology*; D060909:Economics, Behavioral; D005260:Female; D019416:Head Movements; D006801:Humans; D021621:Imaging, Three-Dimensional; D007175:Impulsive Behavior / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000098:blood supply / Q000502:physiology; D010100:Oxygen / Q000097:blood; D011237:Predictive Value of Tests; D012146:Rest / Q000502:physiology*; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D010100:Oxygen