title: Study of glycol chitosan-carboxymethyl β-cyclodextrins as anticancer drugs carrier.
abstract: Efficient target delivery system for insoluble anticancer drugs to increase the intracellular drug concentration has become a focus in cancer therapy. Herein, glycol chitosan-carboxymethyl β-cyclodextrins (G-chitosan-CM-dextrins) was synthesized for delivering different hydrophobic anticancer drugs. Surface plasmon resonance and UV-vis spectroscopy results showed that all the three anticancer drugs (5-fluorouracil, doxorubicin, and vinblastine) could be successfully loaded into the cavities of the covalently linked CM-dextrins. Moreover, the free carboxymethyl groups could enhance the binding interactions between the covalently linked CM-dextrins and anticancer drugs. Release behaviors with pH changes of the three drugs were also explored, result showed different drugs would be released by different ways, as for doxorubicin, pH sensitive release has been realized. The obtained G-chitosan-CM-dextrins carrier has both mucoadhesive property of G-chitosan and hydrophobic cavities of β-cyclodextrins. Therefore, the new synthesized G-chitosan-CM-dextrins carrier exhibits a promising potential capability for anticancer drug delivery in tumor therapy.
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Haina
authors.initials: H
authors.lastname: Tan
authors.forename: Fei
authors.initials: F
authors.lastname: Qin
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Chen
authors.forename: Songbai
authors.initials: S
authors.lastname: Han
authors.forename: Wu
authors.initials: W
authors.lastname: Lu
authors.forename: Xin
authors.initials: X
authors.lastname: Yao
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000032:analysis* / Q000737:chemistry; D005472:Fluorouracil / Q000008:administration & dosage; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D020349:Surface Plasmon Resonance; D014747:Vinblastine / Q000008:administration & dosage; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D047392:beta-Cyclodextrins; C441457:carboxymethyl-beta-cyclodextrin; C118638:glycol-chitosan; D014747:Vinblastine; D004317:Doxorubicin; D048271:Chitosan; D005472:Fluorouracil