title: MCCC1/LAMP3 reduces risk of sporadic Parkinson's disease in Han Chinese.
abstract: BACKGROUND
  A recent large-scale replication and heterogeneity study reported the new described GWAS locus (MCCC1/LAMP3 rs11711441) was associated with a reduced risk of Parkinson disease (PD) in Asian and Caucasian populations. Its role is still unknown in a Han Chinese population from mainland China. We genotyped the rs11711441 variant to investigate the association with risk of PD.
  
  
  METHODS
  Using a case-control methodology, a total of 1428 Han Chinese study subjects were genotyped. We also conducted further stratified analysis according to age at onset and compared the clinical characteristics of GA + AA subjects with GG subjects.
  
  
  RESULTS
  In this study, we confirmed that the A allele of MCCC1/LAMP3 (rs11711441) polymorphism reduces the risk to develop sporadic PD (P = 0.043). Additionally, subjects with GA + AA genotypes have a reduced risk compared to those with GG genotype (P = 0.022). The association was seen among the older age group (P = 0.014), but was not significant among the younger age group (P = 0.641). No significant differences were observed in gender, age at onset, and onset symptoms between GA + AA subjects and GG subjects.
  
  
  CONCLUSIONS
  Our study, the first from Mainland China demonstrates that MCCC1/LAMP3 (rs11711441) is associated with a lower risk of PD. Further studies in additional Chinese populations and other cohorts will be useful.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: N N
authors.initials: NN
authors.lastname: Li
authors.forename: E K
authors.initials: EK
authors.lastname: Tan
authors.forename: X L
authors.initials: XL
authors.lastname: Chang
authors.forename: X Y
authors.initials: XY
authors.lastname: Mao
authors.forename: D M
authors.initials: DM
authors.lastname: Zhao
authors.forename: J H
authors.initials: JH
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Liao
authors.forename: R
authors.initials: R
authors.lastname: Peng
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D051907:Lysosomal Membrane Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D059666:Lysosomal-Associated Membrane Protein 3
chemical_list: D051907:Lysosomal Membrane Proteins; D009363:Neoplasm Proteins; C114233:LAMP3 protein, human; D059666:Lysosomal-Associated Membrane Protein 3
keywords: MCCC1/LAMP3; Parkinson's disease; rs11711441