title: Airway management using a supraglottic airway device without endotracheal intubation for positive ventilation of anaesthetized rats.
abstract: Endotracheal intubation is often necessary for positive pressure ventilation of rats during open thoracic surgery. Since endotracheal intubation in rats is technically difficult and is associated with numerous complications, many techniques using various devices have been described in the scientific literature. In this study, we compared the effectiveness of airway management of a home-made supraglottic airway device (SAD), which is cheap to fabricate and easy to place with that of an endotracheal intubation tube in enflurane-anaesthetized rats. Twenty male Sprague-Dawley rats (200-300 g) were randomly assigned to two equal groups for positive pressure mechanical ventilation using either the SAD or an endotracheal intubation tube. The carotid artery of each rat was cannulated for continuous blood pressure measurements and obtaining blood samples for determination of oxygen tension, carbon dioxide tension, and blood acidity before, during and after SAD placement or endotracheal intubation. Proper placement of the SAD was confirmed by observing chest wall movements that coincided with the operation of the mechanical ventilator. No complications and adverse events were encountered in the rats in which the SAD was placed, during SAD placement and immediate removal, during their mechanical ventilation through the SAD, and one week after SAD removal. From the results of blood gas analyses, we conclude that anaesthetized rats can be successfully ventilated using an SAD for open thoracic surgery.
authors.affiliation: Department of Anesthesiology, Paik Hospital, Inje University, Gaegumdong, Jingu, Busan, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Cheong
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: M H
authors.initials: MH
authors.lastname: Kim
authors.forename: K R
authors.initials: KR
authors.lastname: Cho
authors.forename: S H
authors.initials: SH
authors.lastname: Lim
authors.forename: K M
authors.initials: KM
authors.lastname: Lee
authors.forename: M Y
authors.initials: MY
authors.lastname: Park
authors.forename: Y I
authors.initials: YI
authors.lastname: Yang
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: C S
authors.initials: CS
authors.lastname: Choi
mesh_terms: D058109:Airway Management / Q000009:adverse effects / Q000295:instrumentation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D000818:Animals; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D004737:Enflurane / Q000008:administration & dosage; D007442:Intubation, Intratracheal / Q000009:adverse effects / Q000295:instrumentation / Q000662:veterinary*; D008297:Male; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration / Q000009:adverse effects / Q000295:instrumentation / Q000662:veterinary*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018685:Anesthetics, Inhalation; D002245:Carbon Dioxide; D004737:Enflurane; D010100:Oxygen