title: Therapeutic cancer vaccines in the treatment of non-small-cell lung cancer.
abstract: Therapeutic vaccines are different from the well-known prophylactic vaccines in that they are designed to treat patients already suffering from a disease instead of preventing the disease in healthy individuals. Several therapeutic vaccines are today in late-stage clinical development for non-small-cell lung cancer. These vaccines use different approaches including peptides, cell lines and viral vectors, and explore different settings within the pathology. Some are given in monotherapy while others are combined with the classic therapies used with non-small-cell lung cancer. This review gives a summary of the therapeutic vaccines currently in late-stage clinical development for non-small-cell lung cancer.
authors.affiliation: Transgene SA, Boulevard Gonthier d'Andernach, Parc d'Innovation-CS80166, 67405 Illkirch Graffenstaden Cedex, France. limacher@transgene.fr
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Limacher
authors.forename: Clémentine
authors.initials: C
authors.lastname: Spring-Giusti
authors.forename: Nadine
authors.initials: N
authors.lastname: Bellon
authors.forename: Philippe
authors.initials: P
authors.lastname: Ancian
authors.forename: Ronald
authors.initials: R
authors.lastname: Rooke
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Bonnefoy
mesh_terms: D019496:Cancer Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods*; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008562:Membrane Glycoproteins / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use
chemical_list: D019496:Cancer Vaccines; D008562:Membrane Glycoproteins; C518275:TG4010