title: Overtone mobility spectrometry: part 5. Simulations and analytical expressions describing overtone limits.
abstract: Mathematical expressions for the analytical duty cycle associated with different overtones in overtone mobility spectrometry are derived from the widths of the transmitted packets of ions under different instrumental operating conditions. Support for these derivations is provided through ion trajectory simulations. The outcome of the theory and simulations indicates that under all operating conditions there exists a limit or maximum observable overtone that will result in ion transmission. Implications of these findings on experimental design are discussed.
authors.affiliation: Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Ewing
authors.forename: Steven M
authors.initials: SM
authors.lastname: Zucker
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Valentine
authors.forename: David E
authors.initials: DE
authors.lastname: Clemmer
mesh_terms: D003198:Computer Simulation; D007477:Ions / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods*; D008962:Models, Theoretical; D010455:Peptides / Q000737:chemistry
chemical_list: D007477:Ions; D010455:Peptides