title: Protective Effect of Urtica dioica L. (Urticaceae) on Morphometric and Morphologic Alterations of Seminiferous Tubules in STZ Diabetic Rats.
abstract: OBJECTIVE
  Urtica dioica L. has been known as a medicinal plant in the world. This study was conducted to determine the effects of the hydroalcoholic extract of Urtica dioica leaves on seminiferous tubules of diabetic rats.
  
  
  METHODS
  Animals were allocated to control, diabetic and protective groups. Treated animals received extract of U. dioica (100 mg/ kg/ day) IP for the first 5 days and STZ injection on the 6th day. After 5 weeks, testes removed and stained with H&E technique.
  
  
  RESULTS
  Tubular cell disintegration, sertoli and spermatogonia cell vacuolization, and decrease in sperm concentration observed in diabetic in comparison with control and protective groups. External seminiferous tubular diameter and seminiferous epithelial height significantly reduced (P< 0.05) in diabetic compared with controls, and these parameters increased (P< 0.05) in the treated compared with diabetics.
  
  
  CONCLUSIONS
  Hydroalcoholic extract of U. dioica, before induction of diabetes; has protective role on seminiferous tubules alterations.
authors.affiliation: Department of Anatomy (Embryology and Histology), Golestan University of Medical Sciences, Gorgan, Iran.
authors.forename: Mohammad Jafar
authors.initials: MJ
authors.lastname: Golalipour
authors.forename: Babak
authors.initials: B
authors.lastname: Kabiri Balajadeh
authors.forename: Soraya
authors.initials: S
authors.lastname: Ghafari
authors.forename: Ramin
authors.initials: R
authors.lastname: Azarhosh
authors.forename: Vahid
authors.initials: V
authors.lastname: Khori
keywords: Diabet mellitus; Morphometry; Rats; Seminiferous tubules; Testis; Urtica dioica