title: Serum Concentrations of S100B are not Affected by Cycling to Exhaustion With or Without Vibration.
abstract: The calcium-binding protein S100B is produced primarily by astrocytes and exerts concentration-dependent paracrine and autocrine effects on neurons and glia. The numerous findings of a correlation between S100B and traumatic brain injury (TBI) have resulted in the employment of this protein as a clinical biomarker for such injury. Our present aim was to determine whether cycling with (V) or without (NV) vibration alters serum concentrations of S100B. Twelve healthy, male non-smokers (age: 25.3±1.6 yrs, body mass: 74.2±5.9 kg, body height: 181.0±3.7 cm, VO2peak: 56.9±5.1 ml·min(-1)·kg(-1) (means ± SD)) completed in random order two separate trials to exhaustion on a vibrating bicycle (amplitude 4 mm and frequency 20 Hz) connected to an ergometer. The initial workload of 100 W was elevated by 50 W every 5 min and the mean maximal period of exercise was 25:27±1:30 min. The S100B in venous blood taken at rest, immediately after the test, and 30, 60 and 240 min post-exercise exhibited no significant differences (p>0.05), suggesting that cycling with and without vibration does not influence this parameter.
authors.affiliation: Institute of Motor Control and Movement Technique, German Sport University Cologne, Cologne, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Schulte
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schiffer
authors.forename: Billy
authors.initials: B
authors.lastname: Sperlich
authors.forename: Heinz
authors.initials: H
authors.lastname: Kleinöder
authors.forename: Hans Christer
authors.initials: HC
authors.lastname: Holmberg
keywords: biomarker; endurance; hormone; neurotrophin; serum