title: Results at 10 to 14 years after osteochondral autografting (mosaicplasty) in articular cartilage defects in the knee.
abstract: OBJECTIVE
  The aim of this study was to evaluate the medium-term (5-9 years) and long-term (10-14 years) outcomes of mosaicplasty in the knee and identify possible risk factors for poor outcome.
  
  
  METHODS
  We included patients 60 years or younger with symptomatic focal full-thickness chondral lesions. Seventy-three patients (87%) with median age of 34 years were available for analyses. Clinical outcome was evaluated by Lysholm score and VAS of pain.
  
  
  RESULTS
  Both the mean Lysholm score and mean VAS pain score improved significantly from baseline, 49 (SD 17) and 58 (SD 23), respectively, to both the mid-term follow-up, 72 (SD18, p<0.001) and 27 (SD 20, p<0.001), respectively, and the long-term follow-up, 72 (SD 21, p<0.001) and 33 (SD 23, p<0.001), respectively. A poor outcome at the long-term follow-up - defined as a Lysholm score of 64 or less or having had a knee replacement - was found in 40%. A poor outcome was more frequent in patients 40 years or older (59%), in women (61%) and in defects with an area of 3 cm(2) or more (57%). Conversely, in a subgroup of male individuals younger than 40 years with defect size less than 3 cm(2) the failure rate was 12.5% and the mean Lysholm score was 82 (SD 16).
  
  
  CONCLUSIONS
  We conclude that the long-term clinical outcome after mosaicplasty varies greatly depending on age, gender and the size of the lesion.
  
  
  METHODS
  IV-Retrospective Case Series.
authors.affiliation: Deaconess University Hospital, Haraldsplass, Bergen, Norway. eirik.solheim@uib.no
authors.forename: Eirik
authors.initials: E
authors.lastname: Solheim
authors.forename: Janne
authors.initials: J
authors.lastname: Hegna
authors.forename: Jannike
authors.initials: J
authors.lastname: Øyen
authors.forename: Thomas
authors.initials: T
authors.lastname: Harlem
authors.forename: Torbjørn
authors.initials: T
authors.lastname: Strand
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D019645:Arthroplasty, Replacement, Knee / Q000706:statistics & numerical data; D002356:Cartilage / Q000637:transplantation*; D002358:Cartilage, Articular / Q000293:injuries* / Q000601:surgery*; D005260:Female; D005269:Femur / Q000637:transplantation*; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012189:Retrospective Studies; D012737:Sex Factors; D014182:Transplantation, Autologous; D064232:Visual Analog Scale; D055815:Young Adult