title: A cascade approach to fused indolizinones through Lewis acid-copper(I) relay catalysis.
abstract: A relay catalytic cascade process involving Lewis acid triggered ring-opening of cyclopropyl ketones with nitriles, the copper(I)-catalyzed Ritter process, and acid-promoted N-acyliminium ion cyclization is described, which efficiently provides thieno-, furano-, and benzo-indolizinones in moderate to good yields.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, PR China.
authors.forename: Huawen
authors.initials: H
authors.lastname: Huang
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Ji
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007212:Indolizines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry
chemical_list: D007212:Indolizines; D007659:Ketones; D058116:Lewis Acids; D009570:Nitriles; D003300:Copper