title: NK cell-released exosomes: Natural nanobullets against tumors.
abstract: We have recently reported that human natural killer (NK) cells release exosomes that express both NK-cell markers and cytotoxic molecules. Similar results were obtained with circulating exosomes from human healthy donors. Both NK-cell derived and circulating exosomes exerted a full functional activity and killed both tumor and activated immune cells. These findings indicate that NK-cell derived exosomes might constitute a new promising therapeutic tool.
authors.affiliation: Unit of Antitumor Drugs; Department of Therapeutic Research and Medicines Evaluation; Istituto Superiore di Sanità; Rome, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fais
keywords: exosomes; nanomedicine; natural killer; perorin; theranostic