title: A rare case of ectopic adrenocorticotropic hormone syndrome caused by a metastatic neuroendocrine tumor of the pancreas detected by 68Ga-DOTANOC and 18F-FDG PET/CT.
abstract: We report a rare case of ectopic adrenocorticotropic hormone (ACTH) syndrome caused by a metastatic neuroendocrine tumor (NET) of the pancreas detected by PET/CT using different tracers. A 43-year-old female patient with Cushing syndrome (CS) by suspected ectopic ACTH secretion underwent a 68Ga-DOTANOC and a 18F-FDG PET/CT. Both these functional imaging techniques revealed increased tracer uptake in a pancreatic mass and multiple liver metastases. Histology showed the presence of a mildly differentiated pancreatic NET. 68Ga-DOTANOC PET/CT may be a useful functional imaging method, complementary to 18F-FDG PET/CT, in detecting ACTH-secreting pancreatic NETs.
authors.affiliation: Institute of Nuclear Medicine, Department of Bioimaging and Radiological Sciences, Catholic University of the Sacred Heart, Rome, Italy. giorgiomednuc@libero.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Treglia
authors.forename: Enrica
authors.initials: E
authors.lastname: Salomone
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Petrone
authors.forename: Andrea
authors.initials: A
authors.lastname: Giaccari
authors.forename: Guido
authors.initials: G
authors.lastname: Rindi
authors.forename: Vittoria
authors.initials: V
authors.lastname: Rufini
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000000981:diagnostic imaging / Q000209:etiology*; D000328:Adult; D002454:Cell Differentiation; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D064847:Multimodal Imaging; D009362:Neoplasm Metastasis; D018358:Neuroendocrine Tumors / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D009942:Organometallic Compounds; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: C504894:68Ga-DOTANOC; D009942:Organometallic Compounds; D019788:Fluorodeoxyglucose F18; D005947:Glucose