title: Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers.
abstract: Sinonasal undifferentiated carcinoma is a highly aggressive lesion arising in the superior nasal cavity and paranasal sinuses. Differential diagnosis is wide because a range of similar lesions can present at this site. There is increasing evidence that sinonasal undifferentiated carcinoma is a surface (Schneiderian) epithelial-derived malignancy, with or without concurrent neuroendocrine differentiation. Prognosis is poor; recurrence with metastasis to lymph nodes and distant sites is frequent. A combination of radical surgery, chemotherapy and radiotherapy appears to provide the best chance of survival.
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. diana.bell@mdanderson.org
authors.forename: Diana
authors.initials: D
authors.lastname: Bell
authors.forename: Ehab Y
authors.initials: EY
authors.lastname: Hanna
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D003937:Diagnosis, Differential; D006801:Humans; D008444:Maxillary Sinus Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor