title: A direct and mild formylation method for substituted benzenes utilizing dichloromethyl methyl ether-silver trifluoromethanesulfonate.
abstract: A silver trifluoromethanesulfonate (AgOTf)-promoted direct and mild formylation of benzenes has been developed. The reaction utilizing dichloromethyl methyl ether (Cl2CHOMe) and AgOTf powerfully formylated various substituted benzenes under temperature conditions as low as -78 °C without losing the protecting groups on the phenolic hydroxyl group.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Ohsawa
authors.forename: Masahito
authors.initials: M
authors.lastname: Yoshida
authors.forename: Takayuki
authors.initials: T
authors.lastname: Doi
mesh_terms: D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D001725:Bis(Chloromethyl) Ether / Q000031:analogs & derivatives* / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001555:Benzene Derivatives; D008698:Mesylates; D001725:Bis(Chloromethyl) Ether; C012077:trifluoromethanesulfonic acid