title: In vivo recordings of brain activity using organic transistors.
abstract: In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and for brain-machine interfaces. Organic electronic devices constitute a promising candidate because of their mechanical flexibility and biocompatibility. Here we demonstrate the engineering of an organic electrochemical transistor embedded in an ultrathin organic film designed to record electrophysiological signals on the surface of the brain. The device, tested in vivo on epileptiform discharges, displayed superior signal-to-noise ratio due to local amplification compared with surface electrodes. The organic transistor was able to record on the surface low-amplitude brain activities, which were poorly resolved with surface electrodes. This study introduces a new class of biocompatible, highly flexible devices for recording brain activity with superior signal-to-noise ratio that hold great promise for medical applications.
authors.affiliation: Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541 Gardanne, France.
authors.forename: Dion
authors.initials: D
authors.lastname: Khodagholy
authors.forename: Thomas
authors.initials: T
authors.lastname: Doublet
authors.forename: Pascale
authors.initials: P
authors.lastname: Quilichini
authors.forename: Moshe
authors.initials: M
authors.lastname: Gurfinkel
authors.forename: Pierre
authors.initials: P
authors.lastname: Leleux
authors.forename: Antoine
authors.initials: A
authors.lastname: Ghestem
authors.forename: Esma
authors.initials: E
authors.lastname: Ismailova
authors.forename: Thierry
authors.initials: T
authors.lastname: Hervé
authors.forename: Sébastien
authors.initials: S
authors.lastname: Sanaur
authors.forename: Christophe
authors.initials: C
authors.lastname: Bernard
authors.forename: George G
authors.initials: GG
authors.lastname: Malliaras
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation*; D004569:Electroencephalography; D055724:Electrophysiological Phenomena / Q000502:physiology*; D004827:Epilepsy / Q000503:physiopathology; D051381:Rats; D020318:Rats, Long-Evans; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013003:Somatosensory Cortex / Q000502:physiology; D014173:Transistors, Electronic