title: Multilayered textile coating based on a β-cyclodextrin polyelectrolyte for the controlled release of drugs.
abstract: The aim of this work was to develop the formation of multilayered coating incorporating a cyclodextrin polyelectrolyte onto a non-woven polyethylene terephthalate (PET) textile support in order to obtain reservoir and sustained release properties towards bioactive molecules. We optimized the multilayer assembly immobilization onto the PET surface according to the layer-by-layer (LbL) deposition process. After a pre-treatment of the textile support aiming to offer a sufficient ionic character to the surface, it was alternatively immersed into two polyelectrolytes aqueous solutions consisting of chitosan (CHT) as polycation on the one hand, and a β-cyclodextrin polymer (polyCTR-βCD) as polyanion on the other hand. In a second approach, a TBBA/polyCTR-βCD complex (4-tert-butylbenzoic acid, TBBA) was used in order to load the system with a drug model whose kinetics of release was assessed. Gravimetry, microscopy, OWLS, colorimetric titration, infrared and zetametry were used as characterization techniques. An effective deposition on the textile surface due to ionic interactions with alternation of up to 10 layers of each of both polyelectrolytes was clearly evidenced. However, we observed that layer formation occurred to a lesser extent when TBBA/polyCTR-βCD complex was applied instead of polyCTR-βCD alone. The release study showed that drug reservoir properties and release kinetics could be controlled by the number of layers in the system and that TBBA release was faster than the multilayered coating degradation.
authors.affiliation: Université Lille 1, Unité Matériaux et Transformations UMR CNRS 8207, Villeneuve d'Ascq, France.
authors.forename: Adeline
authors.initials: A
authors.lastname: Martin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Tabary
authors.forename: Laurent
authors.initials: L
authors.lastname: Leclercq
authors.forename: Jatupol
authors.initials: J
authors.lastname: Junthip
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Degoutin
authors.forename: François
authors.initials: F
authors.lastname: Aubert-Viard
authors.forename: Frédéric
authors.initials: F
authors.lastname: Cazaux
authors.forename: Joël
authors.initials: J
authors.lastname: Lyskawa
authors.forename: Ludovic
authors.initials: L
authors.lastname: Janus
authors.forename: Marc
authors.initials: M
authors.lastname: Bria
authors.forename: Bernard
authors.initials: B
authors.lastname: Martel
mesh_terms: D001565:Benzoates / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D007700:Kinetics; D011093:Polyethylene Terephthalates / Q000737:chemistry; D013784:Textiles; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D001565:Benzoates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011093:Polyethylene Terephthalates; D047392:beta-Cyclodextrins; C034290:4-tert-butylbenzoic acid; D048271:Chitosan