title: Creation of resveratrol-enriched rice for the treatment of metabolic syndrome and related diseases.
abstract: Resveratrol has been clinically shown to possess a number of human health benefits. As a result, many attempts have been made to engineer resveratrol production in major cereal grains but have been largely unsuccessful. In this study, we report the creation of a transgenic rice plant that accumulates 1.9 µg resveratrol/g in its grain, surpassing the previously reported anti-metabolic syndrome activity of resveratrol through a synergistic interaction between the transgenic resveratrol and the endogenous properties of the rice. Consumption of our transgenic resveratrol-enriched rice significantly improved all aspects of metabolic syndrome and related diseases in animals fed a high-fat diet. Compared with the control animals, the resveratrol-enriched rice reduced body weight, blood glucose, triglycerides, total cholesterol, and LDL-cholesterol by 24.7%, 22%, 37.4%, 27%, and 59.6%, respectively. The resveratrol-enriched rice from our study may thus provide a safe and convenient means of preventing metabolic syndrome and related diseases without major lifestyle changes or the need for daily medications. These results also suggest that future transgenic plants could be improved if the synergistic interactions of the transgene with endogenous traits of the plant are considered in the experimental design.
authors.affiliation: National Institute of Crop Science, Rural Development Administration, Iksan, Chonbuk, Korea.
authors.forename: So-Hyeon
authors.initials: SH
authors.lastname: Baek
authors.forename: Woon-Chul
authors.initials: WC
authors.lastname: Shin
authors.forename: Hak-Seung
authors.initials: HS
authors.lastname: Ryu
authors.forename: Dae-Woo
authors.initials: DW
authors.lastname: Lee
authors.forename: Eunjung
authors.initials: E
authors.lastname: Moon
authors.forename: Chun-Sun
authors.initials: CS
authors.lastname: Seo
authors.forename: Eunson
authors.initials: E
authors.lastname: Hwang
authors.forename: Hyun-Seo
authors.initials: HS
authors.lastname: Lee
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Ahn
authors.forename: Youngju
authors.initials: Y
authors.lastname: Jeon
authors.forename: Hyeon-Jung
authors.initials: HJ
authors.lastname: Kang
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Roshan
authors.initials: R
authors.lastname: D'Souza
authors.forename: Hyeon-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Seong-Tshool
authors.initials: ST
authors.lastname: Hong
authors.forename: Jong-Seong
authors.initials: JS
authors.lastname: Jeon
mesh_terms: D000217:Acyltransferases / Q000235:genetics / Q000378:metabolism; D000273:Adipose Tissue; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005527:Food, Fortified; D005960:Glucosides / Q000378:metabolism; D005964:Glucosyltransferases / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D012275:Oryza / Q000235:genetics*; D018515:Plant Leaves / Q000187:drug effects / Q000201:enzymology; D030821:Plants, Genetically Modified; D000077185:Resveratrol; D012639:Seeds / Q000187:drug effects / Q000378:metabolism; D056564:Sirtuin 1 / Q000378:metabolism; D013267:Stilbenes / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D005960:Glucosides; D008055:Lipids; D013267:Stilbenes; D000217:Acyltransferases; C022674:stilbene synthase; D005964:Glucosyltransferases; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D000077185:Resveratrol; C058229:polydatin