title: Protective role of ginseng against gentamicin induced changes in kidney of albino mice.
abstract: BACKGROUND
  Use of gentamicin is now limited due to its toxic effects, mainly on kidney and vestibular system. Herbal products including ginseng has been reported to possess protective effects against drugs induced nephrotoxicity in experimental animals. The current investigation was designed to evaluate the effects of ginseng on gentamicin induced nephrotoxicity.
  
  
  METHODS
  Eighteen male albino mice of 6-8 weeks age, were divided into 3 groups. Group-A served as control and was given normal mouse diet; Group-B was given 80 mg/Kg/day of gentamicin intraperitoneally dissolved in 1 ml of distilled water for fifteen days. Group-C was given 80 mg/Kg/day of gentamicin intraperitoneally dissolved in 1 ml of distilled water along with 100 mg/Kg/day of ginseng orally dissolved in 1 ml of distilled water, also for fifteen days. At the end of the experiment, blood was drawn from each animal by cardiac puncture for renal function tests. Each animal was then sacrificed and kidneys removed for routine histological studies.
  
  
  RESULTS
  In group B, weight of the animals and kidneys decreased and there was significant increase in mean serum urea, creatinine and intraluminal diameter (p < 0.001) of proximal convoluted tubules as compared to the controls (group-A). Moderate to severe necrotic and degenerative changes in proximal convoluted tubules were seen in this group. When the Ginseng and gentamicin were given together (group-C), a statistically significant improvement in the mean body and kidney weight along with improvement in renal function tests and tubular diameter were seen (p < 0.001).
  
  
  CONCLUSIONS
  It appears that Ginseng has some protective role against gentamicin induced nephrotoxicity.
authors.affiliation: Department of Anatomy, Amna Inayat Medical College, Sheikhupura, Pakistan.
authors.forename: Muhammad Irfan
authors.initials: MI
authors.lastname: Qadir
authors.forename: Mohammad
authors.initials: M
authors.lastname: Tahir
authors.forename: Khalid P
authors.initials: KP
authors.lastname: Lone
authors.forename: Bushra
authors.initials: B
authors.lastname: Munir
authors.forename: Waqas
authors.initials: W
authors.lastname: Sami
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D005839:Gentamicins / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D007677:Kidney Function Tests; D008297:Male; D051379:Mice; D009929:Organ Size; D005894:Panax; D011897:Random Allocation
chemical_list: D005839:Gentamicins