title: Screening for predementia AD: time-dependent operating characteristics of episodic memory tests.
abstract: OBJECTIVE
  Data from the Einstein Aging Study (EAS) were used to prospectively evaluate the free recall score from the free and cued selective reminding test (FCSRT-FR) and logical memory I immediate recall (LM-IR) subtest of the Wechsler memory scale-revised for prediction of incident Alzheimer disease (AD) dementia among individuals from a community-based cohort with memory complaints.
  
  
  METHODS
  Analyses included 854 participants, age ≥70 years, who initially had no dementia, and had memory complaints. Clinic evaluations were completed annually and AD dementia was diagnosed using standard criteria (n = 86 cases; average follow-up 4.1 years). Time-dependent receiver operating characteristic analysis was used to evaluate the prognostic ability of FCSRT-FR and LM-IR for incident AD over various durations of follow-up.
  
  
  RESULTS
  For identifying those with memory complaints who will develop incident AD dementia over 2-4 years, the FCSRT-FR had better operating characteristics than LM-IR. APOE ε4 status, age, and education did not affect cut points; however, positive predictive values were higher among APOE ε4-positive individuals.
  
  
  CONCLUSIONS
  For follow-up intervals of 2-4 years, the FCSRT-FR is more predictive than the LM-IR for identifying individuals with memory complaints who will develop incident AD. APOE ε4 status improves positive predictive value, but does not affect the choice of optimal cuts.
authors.affiliation: Department of Neurology, Division of Cognitive Aging and Dementia and the Einstein Aging Study, Albert Einstein College of Medicine, Bronx, NY, USA. carol.derby@einstein.yu.ed
authors.forename: Carol A
authors.initials: CA
authors.lastname: Derby
authors.forename: Leah C
authors.initials: LC
authors.lastname: Burns
authors.forename: Cuiling
authors.initials: C
authors.lastname: Wang
authors.forename: Mindy J
authors.initials: MJ
authors.lastname: Katz
authors.forename: Molly E
authors.initials: ME
authors.lastname: Zimmerman
authors.forename: Gilbert
authors.initials: G
authors.lastname: L'italien
authors.forename: Zhenchao
authors.initials: Z
authors.lastname: Guo
authors.forename: Robert M
authors.initials: RM
authors.lastname: Berman
authors.forename: Richard B
authors.initials: RB
authors.lastname: Lipton
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008403:Mass Screening; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology; D061212:Memory, Episodic; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D013997:Time Factors
chemical_list: D053327:Apolipoprotein E4