title: Transcriptional profile of Marek's disease virus genes in chicken thymus during different phases of MDV infection.
abstract: In this study, 86 Marek's disease virus (MDV) transcripts were detected in chicken thymus infected with RB1B strain. Forty-seven of them, which were mainly involved in viral replication and immune escape, were detected at 7 days postinfection (dpi). Expression of most of the genes was increased at 21 and 28 dpi but reduced or shut down at 14 dpi. Unlike others tissues, we found that a latent infection was established at 14 dpi in infected thymus. Here, we show the kinetics of expression of MDV transcripts and their relative expression in infected thymus.
authors.affiliation: Ministry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, No. 12 East Wenhui Road, Yangzhou, Jiangsu 225009, People's Republic of China.
authors.forename: Xuming
authors.initials: X
authors.lastname: Hu
authors.forename: Aijian
authors.initials: A
authors.lastname: Qin
authors.forename: Ji
authors.initials: J
authors.lastname: Miao
authors.forename: Wencai
authors.initials: W
authors.lastname: Xu
authors.forename: Chuan
authors.initials: C
authors.lastname: Yu
authors.forename: Kun
authors.initials: K
authors.lastname: Qian
authors.forename: Hongxia
authors.initials: H
authors.lastname: Shao
mesh_terms: D000818:Animals; D002645:Chickens; D005814:Genes, Viral; D057131:Immune Evasion; D025922:Mardivirus / Q000235:genetics* / Q000254:growth & development* / Q000276:immunology / Q000502:physiology; D008380:Marek Disease / Q000821:virology*; D013950:Thymus Gland / Q000821:virology*; D013997:Time Factors; D059467:Transcriptome; D014779:Virus Replication