title: Adiponectin and visfatin levels in extremely low birth weight infants; they are also at risk for insulin resistance.
abstract: OBJECTIVE
  The aim of this study was to assess adiponectin, visfatin, HOMA-IR, glucose and triglyceride levels in term, preterm and extremely low birth weight (ELBW) babies. Each of these three groups was subdivided into two groups as small-for-gestational age (SGA), and appropriate-for-gestational age (AGA). 30 term, 30 preterm and 30 extremely low birth weight infants were included into the study.
  
  
  RESULTS
  There was no significant difference in term and preterm infants for serum adiponectin, visfatin, and HOMA-IR levels. There were also no significant differences between term and preterm infants for glucose and triglycerides. The serum visfatin, insulin and HOMA-IR levels (p = 0.001, p = 0.001 and p < 0.05, respectively) were higher in ELBW group than preterm group. Comparing the subgroups as SGA and AGA in all main groups, only in ELBW group there were no significant differences in serum adiponectin, visfatin, HOMA-IR and insulin levels.
  
  
  CONCLUSIONS
  We suggest that visfatin can be used as an early indicator of insulin resistance. Independent of being SGA, ELBW itself may be a risk factor for insulin resistance. In the follow-up of these babies the risk of obesity, metabolic syndrome and cardiovascular diseases may be increased as in SGA babies.
authors.affiliation: Department of Neonatology, GATA Medical Faculty, Ankara, Turkey. ferhat_cocuk@hotmail.com
authors.forename: F
authors.initials: F
authors.lastname: Cekmez
authors.forename: F E
authors.initials: FE
authors.lastname: Canpolat
authors.forename: O
authors.initials: O
authors.lastname: Pirgon
authors.forename: G
authors.initials: G
authors.lastname: Aydemir
authors.forename: I A
authors.initials: IA
authors.lastname: Tanju
authors.forename: F A
authors.initials: FA
authors.lastname: Genc
authors.forename: T
authors.initials: T
authors.lastname: Tunc
authors.forename: S
authors.initials: S
authors.lastname: Aydinöz
authors.forename: S
authors.initials: S
authors.lastname: Yildirim
authors.forename: O M
authors.initials: OM
authors.lastname: Ipcioglu
authors.forename: S U
authors.initials: SU
authors.lastname: Sarici
mesh_terms: D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D052577:Infant, Extremely Low Birth Weight / Q000097:blood*; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D012306:Risk; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D016207:Cytokines; D007328:Insulin; D014280:Triglycerides; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human