title: Molecular typing of PPRV strains detected during an outbreak in sheep and goats in south-eastern Gabon in 2011.
abstract: BACKGROUND
  Peste des petits ruminanats (PPR) is an economically important viral disease affecting goats and sheep. Four genetically distinct lineages of peste des petits ruminants virus (PPRV) have been identified. In Gabon, the virus has not so far been detected.
  
  
  RESULTS
  Epidemiological investigations of Aboumi PPR outbreak revealed a high case fatality rate in sheep (98.9%). We detected and characterized peste des petits ruminants virus (PPRV), in October 2011, during the suspected outbreak in sheep and goats in Aboumi village located in the south-eastern. PPRV RNA was detected in 10 of 14 samples from three sick animals. Phylogenetic analysis revealed that the PPRV strain belonged to lineage IV and was closely related to strain circulating in neighboring Cameroon.
  
  
  CONCLUSIONS
  This is the first molecular detection and typing of the PPRV strain associated with fatal PPR infection in these small ruminants and concrete evidence that PPRV is present and circulating in Gabon.
authors.affiliation: Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
authors.forename: Gael D
authors.initials: GD
authors.lastname: Maganga
authors.forename: Delphine
authors.initials: D
authors.lastname: Verrier
authors.forename: Rodrigo M
authors.initials: RM
authors.lastname: Zerbinati
authors.forename: Christian
authors.initials: C
authors.lastname: Drosten
authors.forename: Jan F
authors.initials: JF
authors.lastname: Drexler
authors.forename: Eric M
authors.initials: EM
authors.lastname: Leroy
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D004196:Disease Outbreaks; D005681:Gabon / Q000453:epidemiology; D005838:Genotype; D015511:Goat Diseases / Q000453:epidemiology* / Q000821:virology; D006041:Goats; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D058889:Molecular Typing; D029021:Peste-des-Petits-Ruminants / Q000453:epidemiology* / Q000821:virology; D018107:Peste-des-petits-ruminants virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology* / Q000821:virology
chemical_list: D012367:RNA, Viral