title: The glucocorticoid antagonist RU-486 suppresses HIV infectivity and replication.
abstract: The effects of RU-486, a glucocorticoid antagonist, on HIV infection and replication in depressed and nondepressed women were studied using ex vivo models of HIV infection. RU-486 treatment of cells decreased HIV reverse transcriptase activity of monocyte-derived macrophages in a model of acute infectivity. RU-486 also decreased HIV viral replication in the chronically-infected T-cell line ACH-2, but not in the promonocyte cell line U1. No differences were associated with depression status. Thus, glucocorticoid antagonism may suppress HIV infectivity and replication ex vivo. Studies to determine the role of glucocorticoid antagonists in the host defense against HIV should be performed.
authors.affiliation: Children’s Hospital of Philadelphia Research Institute, Division of Allergy and Immunology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA. bentont@e-mail.chop.edu
authors.forename: Tami D
authors.initials: TD
authors.lastname: Benton
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Lynch
authors.forename: Benoit
authors.initials: B
authors.lastname: Dubé
authors.forename: David R
authors.initials: DR
authors.lastname: Gettes
authors.forename: Nancy B
authors.initials: NB
authors.lastname: Tustin
authors.forename: David S
authors.initials: DS
authors.lastname: Metzger
authors.forename: Joshua
authors.initials: J
authors.lastname: Blume
authors.forename: Steven D
authors.initials: SD
authors.lastname: Douglas
authors.forename: Dwight L
authors.initials: DL
authors.lastname: Evans
mesh_terms: D000293:Adolescent; D000328:Adult; D002460:Cell Line; D003863:Depression / Q000188:drug therapy / Q000209:etiology / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D015735:Mifepristone / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000187:drug effects / Q000821:virology; D019562:Viral Load / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*; D055815:Young Adult
chemical_list: D006727:Hormone Antagonists; D015735:Mifepristone