title: Long-term outcome of lung transplantation in previous intravenous drug users with talc lung granulomatosis.
abstract: Talc lung granulomatosis results from the intravenous use of medication intended for oral use. Talc (magnesium silicate) acts as filler in some oral medications; when injected intravenously, it deposits in the lungs leading to airflow obstruction and impaired gas exchange. Allocation of donor lungs to previous intravenous drug users is controversial. After a careful selection process, 19 patients with talc lung granulomatosis have received lung allografts in our program. Long-term survival for these patients is excellent and our results suggest the previous use of intravenous drugs should not necessarily preclude lung transplantation.
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. justin.weinkauf@ualberta.ca
authors.forename: J G
authors.initials: JG
authors.lastname: Weinkauf
authors.forename: L
authors.initials: L
authors.lastname: Puttagunta
authors.forename: R
authors.initials: R
authors.lastname: Nador
authors.forename: K
authors.initials: K
authors.lastname: Jackson
authors.forename: K
authors.initials: K
authors.lastname: LaBranche
authors.forename: A
authors.initials: A
authors.lastname: Kapasi
authors.forename: J
authors.initials: J
authors.lastname: Mullen
authors.forename: D L
authors.initials: DL
authors.lastname: Modry
authors.forename: K C
authors.initials: KC
authors.lastname: Stewart
authors.forename: M
authors.initials: M
authors.lastname: Thakrar
authors.forename: K
authors.initials: K
authors.lastname: Doucette
authors.forename: D C
authors.initials: DC
authors.lastname: Lien
mesh_terms: D055030:Drug Users; D005079:Excipients / Q000009:adverse effects*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D006801:Humans; D007275:Injections, Intravenous; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D016040:Lung Transplantation; D008297:Male; D018579:Patient Selection; D012189:Retrospective Studies; D015819:Substance Abuse, Intravenous / Q000150:complications* / Q000534:rehabilitation; D013627:Talc / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005079:Excipients; D013627:Talc