title: Pentoxifylline potentiates antiepileptic activity of diazepam on the model of treatment-resistant focal epilepsy.
abstract: Kindling-syndrome was modeled in male Wistar rats using repeated corazole administration (25-30 mg/kg intraperitoneally). The effects of pentoxifylline (25 and 100 mg/kg intraperitoneally) and diazepam (0.05 and 1 mg/kg intraperitoneally) were studied in 3 weeks after kindling development under conditions of acute observation on the model of penicillin-induced foci in cerebral cortex. An anticonvulsant effect of combined treatment with diazepam and pentoxifylline in the doses, ineffective if administered separately (0.05 and 25 mg/kg intraperitoneally), was demonstrated.
authors.affiliation: Odessa National Medical University, Ukraine; Peoples' Friendship University of Russia, Moscow, Russia. godlevsky@odmu.edu.ua
authors.forename: L S
authors.initials: LS
authors.lastname: Godlevsky
authors.forename: G A
authors.initials: GA
authors.lastname: Drozdova
authors.forename: E V
authors.initials: EV
authors.lastname: Kobolev
authors.forename: V F
authors.initials: VF
authors.lastname: Mustyatsa
authors.forename: V A
authors.initials: VA
authors.lastname: Polyasnyi
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism; D058256:Brain Waves / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology; D003975:Diazepam / Q000494:pharmacology / Q000627:therapeutic use*; D004357:Drug Synergism; D004828:Epilepsies, Partial / Q000188:drug therapy*; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use*; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D010406:Penicillins; D010431:Pentoxifylline / Q000494:pharmacology / Q000627:therapeutic use*; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000927:Anticonvulsants; D016166:Free Radical Scavengers; D010406:Penicillins; D003975:Diazepam; D010431:Pentoxifylline; D010433:Pentylenetetrazole