title: Inflammatory markers in the second trimester prior to clinical onset of preeclampsia, intrauterine growth restriction, and spontaneous preterm birth.
abstract: Low-grade inflammation has been associated with pregnancy complications including preeclampsia (PE), intrauterine growth restriction (IUGR), and spontaneous preterm birth (SPB). In an unmatched, nested case-control study, we assessed the possible predictive association of maternal C-reactive protein (CRP), interferon-γ-inducible protein 10 (IP-10), and soluble urokinase plasminogen activator receptor (suPAR) in second trimester plasma samples in relation to later development of PE (n = 29), IUGR (n = 53), and SPB (n = 9). Inflammatory marker levels in these groups were compared to normotensive healthy pregnant controls (n = 127). We found no statistically significant difference in CRP, IP-10, or suPAR in second trimester plasma samples from pregnant women with later PE, IUGR, and SPB when compared to normotensive healthy controls. Second trimester plasma samples of CRP, IP-10, and suPAR cannot be used as a prognostic marker for PE, IUGR, and SPB.
authors.affiliation: Department of Obstetrics and Gynaecology, Hvidovre Hospital, University of Copenhagen, Kettegaard Allé 30, 2650 Hvidovre, Denmark. sofiehaedersdal@gmail.com
authors.forename: Sofie
authors.initials: S
authors.lastname: Haedersdal
authors.forename: Jannie D
authors.initials: JD
authors.lastname: Salvig
authors.forename: Martine
authors.initials: M
authors.lastname: Aabye
authors.forename: Christian W
authors.initials: CW
authors.lastname: Thorball
authors.forename: Morten
authors.initials: M
authors.lastname: Ruhwald
authors.forename: Steen
authors.initials: S
authors.lastname: Ladelund
authors.forename: Jesper
authors.initials: J
authors.lastname: Eugen-Olsen
authors.forename: Niels J
authors.initials: NJ
authors.lastname: Secher
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D054357:Chemokine CXCL10 / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis*; D006801:Humans; D007249:Inflammation / Q000097:blood; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood; D047928:Premature Birth / Q000175:diagnosis*; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; C524898:PLAUR protein, human; D055293:Receptors, Urokinase Plasminogen Activator; D002097:C-Reactive Protein