title: [The activity of components of system of matrix metalloproteinase and tissue inhibitors of metalloproteinase on different stages of chronic cardiac failure].
abstract: The article discusses the results of detection of activity of matrix metalloproteinase-9, tissue inhibitors of metalloproteinases-4, endotoxin, tumor necrosis factor-alpha, C-reactive protein, sE-selectine in blood of patients with chronic cardiac failure depending on severity of disease. It is demonstrated that progressing of chronic cardiac failure is associated with the increase of level of endotoxemia, activation of systemic inflammation and misbalance in the system of matrix metalloproteinase and tissue inhibitors of metalloproteinase.
authors.forename: E N
authors.initials: EN
authors.lastname: Egorova
authors.forename: M I
authors.initials: MI
authors.lastname: Kuz'mina
authors.forename: V V
authors.initials: VV
authors.lastname: Mazur
authors.forename: M N
authors.initials: MN
authors.lastname: Kalinkin
authors.forename: E S
authors.initials: ES
authors.lastname: Mazur
authors.forename: M A
authors.initials: MA
authors.lastname: Gorshkova
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D002908:Chronic Disease; D004731:Endotoxins / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D019714:Tissue Inhibitor of Metalloproteinases / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D000097792:Tissue Inhibitor of Metalloproteinase-4
chemical_list: D002097:C-Reactive Protein; D004731:Endotoxins; D020780:Matrix Metalloproteinase 9; D020097:Natriuretic Peptide, Brain; D010446:Peptide Fragments; D019714:Tissue Inhibitor of Metalloproteinases; D014409:Tumor Necrosis Factor-alpha; D000097792:Tissue Inhibitor of Metalloproteinase-4; C109794:pro-brain natriuretic peptide (1-76)