title: High melting lipid based approach for drug delivery: solid lipid nanoparticles.
abstract: Poor solubility of newly developed drug molecules is the main problem in recent drug discovery research, so novel drug delivery approaches are being used to deliver these molecular entities for pharmacological action. Colloidal carriers (emulsion, suspensions, liposomes, polymer nanoparticles and solid lipid nanoparticles) have been used to administer poorly soluble drugs, but solid lipid nanoparticles are found to be the most reliable carriers for this type of drugs due to its advantages over other carriers. Solid lipid nanoparticles have the potential to solve the drug delivery problems with safe excipients used in its formulation. In this review all the aspects of solid lipid nanoparticles production, stability, characterization, differentiation based on route, preservation and storage have been discussed.
authors.affiliation: Centre for Material Science and Engineering, National Institute of Technology, Hamirpur 177005 (H.P), India.
authors.forename: Sacheen
authors.initials: S
authors.lastname: Kumar
authors.forename: Jaspreet Kaur
authors.initials: JK
authors.lastname: Randhawa
mesh_terms: D002626:Chemistry, Pharmaceutical; D004333:Drug Administration Routes; D016503:Drug Delivery Systems / Q000379:methods*; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: D008055:Lipids