title: Hypolipidaemic effects of cyanidin 3-glucoside rich extract from black rice through regulating hepatic lipogenic enzyme activities.
abstract: BACKGROUND
  Black rice is rich in anthocyanins, especially cyanidin-3-glucoside (C3G). This study examined the effects of a C3G-rich extract from black rice on hyperlipidaemia induced by a high fat/cholesterol diet (HFCD) in rats.
  
  
  RESULTS
  Male Sprague-Dawley rats were fed either HFCD or HFCD containing 150 mg kg⁻¹ body weight C3G (HFCD+C3G) for 4 weeks. We found that C3G significantly decreased serum levels of total cholesterol, free cholesterol, triglycerides, and free fatty acids in rats fed a HFCD. Similarly, hepatic cholesterol and triglyceride levels and the activities of hepatic lipogenic enzymes (malic enzyme and glucose-6-phosphate dehydrogenase) were significantly reduced by C3G supplementation.
  
  
  CONCLUSIONS
  These results suggest that C3G can ameliorate HFCD-induced hyperlipidaemia in part by modulating the activities of hepatic lipogenic enzymes.
authors.affiliation: Korea Food Research Institute, Seongnam, 463-746, South Korea.
authors.forename: Min Young
authors.initials: MY
authors.lastname: Um
authors.forename: Jiyun
authors.initials: J
authors.lastname: Ahn
authors.forename: Tae Youl
authors.initials: TY
authors.lastname: Ha
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000032:analysis / Q000627:therapeutic use; D002784:Cholesterol / Q000378:metabolism; D019587:Dietary Supplements / Q000032:analysis; D015536:Down-Regulation; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D005960:Glucosides / Q000032:analysis / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000201:enzymology / Q000378:metabolism / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D050155:Lipogenesis; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D012275:Oryza / Q000737:chemistry*; D008517:Phytotherapy; D010858:Pigmentation; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D005960:Glucosides; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; C462279:cyanidin-3-O-beta-glucopyranoside; D002784:Cholesterol; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; C034544:D-malate dehydrogenase (decarboxylating)
keywords: cyanidin-3-glucoside; glucose-6-phosphate dehydrogenase; high fat/cholesterol diet; hypolipidaemic effect; malic enzyme