title: The dual role of ruthenium and alkali base catalysts in enabling a conceptually new shortcut to N-unsubstituted pyrroles through unmasked α-amino aldehydes.
abstract: A virtually salt-free and straightforward bimolecular assembly giving N-unsubstituted pyrroles through fully unmasked α-amino aldehydes, which was enabled by the dual effects of a catalytic ruthenium complex and an alkali metal base, is reported. Either solvent-free or acceptorless dehydrogenation facilitates high atom, step, and pot economy, which are otherwise difficult to achieve in multistep operations involving protection/deprotection.
authors.affiliation: Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Iida
authors.forename: Takashi
authors.initials: T
authors.lastname: Miura
authors.forename: Junki
authors.initials: J
authors.lastname: Ando
authors.forename: Susumu
authors.initials: S
authors.lastname: Saito