title: Two-photon photodynamic therapy by water-soluble self-assembled conjugated porphyrins.
abstract: Studies on two-photon absorption (2PA) photodynamic therapy (PDT) by using three water-soluble porphyrin self-assemblies consisting of ethynylene-linked conjugated bis (imidazolylporphyrin) are reviewed. 2PA cross-section values in water were obtained by an open aperture Z-scan measurement, and values were extremely large compared with those of monomeric porphyrins such as hematoporphyrin. These compounds were found to generate singlet oxygen efficiently upon one- as well as two-photon absorption as demonstrated by the time-resolved luminescence measurement at the characteristic band of singlet oxygen at 1270 nm and by using its scavenger. Photocytotoxicities for HeLa cancer cells were examined and found to be as high as those of hematoporphyrin, demonstrating that these compounds are potential candidates for 2PA-photodynamic therapy agents.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0101, Japan. kogawa@yamanashi.ac.jp
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ogawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kobuke
mesh_terms: D000818:Animals; D006367:HeLa Cells; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D011166:Porphyrins / Q000737:chemistry* / Q000627:therapeutic use*; D026082:Singlet Oxygen / Q000737:chemistry / Q000378:metabolism
chemical_list: D011166:Porphyrins; D026082:Singlet Oxygen