title: [Gerontological features of changes in indicators of lipid peroxidation and antioxidant enzymes in the wall of the small bowel in patients with acute severe peritonitis].
abstract: The aim of the work was to study age related changes of lipid peroxidation and antioxidant system in the wall of the small bowel in patients with severe secondary peritonitis. Group I, control (n=42) was consisted of patients from 30 to 89 years. Age of the group II patients (n=36) was from 30 to 59 years, III (n=43) from 60 to 74 years and IV (n=28) from 75 to 89 years. The obtained results of the study showed a significant increase in the concentration of conjugated dienes in the wall of the small intestine, especially in third grade enteric insufficiency as in patients of the second group, which amounted 0,34±0,03 s.u./mg of lipids, and in elderly patients - 0,38±0,03 cu./mg of lipids and senile patients 0,42±0,04 s.u./mg of lipids. On increasing the concentration of the toxic products of lipid peroxidation in the intestinal wall testified a negative accumulation of malondialdehyde from 6,91±0,38 nmol/g protein in patients of the second group, even with second degree enteral insufficiency to 7,49±0,51 nmol/g of protein for elderly patients (fourth group).
authors.affiliation: P.L. Shupik National Medical Academy of Post-graduate Education, Kiev, Ukraine.
authors.forename: S
authors.initials: S
authors.lastname: Kerashvili
authors.forename: B
authors.initials: B
authors.lastname: Slonetsky
authors.forename: M
authors.initials: M
authors.lastname: Maksimenko
authors.forename: S
authors.initials: S
authors.lastname: Lobanov
authors.forename: A
authors.initials: A
authors.lastname: Batawil
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D000975:Antioxidants; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007421:Intestine, Small / Q000201:enzymology / Q000473:pathology / Q000601:surgery; D015227:Lipid Peroxidation / Q000235:genetics*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D010538:Peritonitis / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism; D000072105:Superoxide Dismutase-1
chemical_list: D000975:Antioxidants; C000606290:SOD1 protein, human; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1