title: Reduction in adiposity, β-cell function, insulin sensitivity, and cardiovascular risk factors: a prospective study among Japanese with obesity.
abstract: BACKGROUND
  A reduction in adiposity may be associated with an improvement in insulin sensitivity and β-cell function as well as cardiovascular disease (CVD) risk factors; however, few studies have investigated these associations in a longitudinal setting.
  
  
  METHODS
  To investigate these associations over a 1-year period, we conducted an observational analysis of 196 Japanese subjects with obesity in the Saku Control Obesity Program. We investigated the relations between changes in adiposity (body mass index [BMI], waist circumference, subcutaneous fat area [SFAT], and visceral fat area [VFAT]) and changes in HbA1c, fasting plasma glucose (FPG), insulin sensitivity index (ISI), the homeostasis model assessment β cell function (HOMA-β), lipids, and blood pressure.
  
  
  RESULTS
  All adiposity changes were positively associated with HbA1c and FPG changes. Reductions in BMI and VFAT were associated with HOMA-β reduction. Reductions in all adiposity measures were associated with an improvement in the ISI. Changes in most adiposity measures were positively associated with changes in blood pressure and lipid levels, except for LDL.
  
  
  CONCLUSIONS
  The present findings provide additional supportive evidence indicating that a reduction in adiposity may lead to an improvement in insulin sensitivity and the reduction of CVD risk factors in obese individuals.
authors.affiliation: Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Goto
authors.forename: Akemi
authors.initials: A
authors.lastname: Morita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Goto
authors.forename: Kijo
authors.initials: K
authors.lastname: Deura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Naomi
authors.initials: N
authors.lastname: Aiba
authors.forename: Takuro
authors.initials: T
authors.lastname: Shimbo
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Terauchi
authors.forename: Motohiko
authors.initials: M
authors.lastname: Miyachi
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Noda
authors.forename: Shaw
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D050154:Adiposity; D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000473:pathology*; D007564:Japan / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids