title: CTX-M-55-type extended-spectrum β-lactamase-producing Shigella sonnei isolated from a Korean patient who had travelled to China.
abstract: We report a case of CTX-M-55-type extended-spectrum β-lactamase (ESBL)-producing Shigella sonnei infection in a 27-year-old Korean woman who had traveled to China. The patient was admitted to the hospital due to abdominal pain, watery diarrhea, and fever (39.3℃). S. sonnei was isolated from her stool specimens, and the pathogen was found to be resistant to cefotaxime due to CTX-M-55-type ESBL. Insertion sequence (IS)Ecp1 was found upstream of the blaCTX-M-55 gene. The blaCTX-M-55 gene was transferred from the S. sonnei isolate to an Escherichia coli J53 recipient by conjugation. Pulsed-field gel electrophoresis and Southern blotting revealed that the blaCTX-M-55 gene was located on a plasmid of approximately 130 kb.
authors.affiliation: Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Wonmok
authors.initials: W
authors.lastname: Lee
authors.forename: Hae-Sun
authors.initials: HS
authors.lastname: Chung
authors.forename: Hyukmin
authors.initials: H
authors.lastname: Lee
authors.forename: Jong Hwa
authors.initials: JH
authors.lastname: Yum
authors.forename: Dongeun
authors.initials: D
authors.lastname: Yong
authors.forename: Seok Hoon
authors.initials: SH
authors.lastname: Jeong
authors.forename: Kyungwon
authors.initials: K
authors.lastname: Lee
authors.forename: Yunsop
authors.initials: Y
authors.lastname: Chong
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D044466:Asian People; D002439:Cefotaxime / Q000494:pharmacology; D002681:China; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D004405:Dysentery, Bacillary / Q000175:diagnosis / Q000382:microbiology*; D016521:Electrophoresis, Gel, Pulsed-Field; D004926:Escherichia coli / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D010957:Plasmids / Q000737:chemistry / Q000235:genetics; D056910:Republic of Korea; D012764:Shigella sonnei / Q000201:enzymology / Q000302:isolation & purification*; D014195:Travel; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; D002439:Cefotaxime
keywords: CTX-M-55; ESBL; Shigella sonnei