title: Impact of age on myocardial uptake of ¹²³I-mIBG in older adult subjects without coronary heart disease.
abstract: BACKGROUND
  The purpose of this study was to examine the relationship between myocardial uptake of (123)I-mIBG and age in older normal adult subjects.
  
  
  METHODS
  94 subjects (age 29-82, mean 58.5) without coronary heart disease were studied. All subjects underwent early and delayed planar and 4-hour SPECT (123)I-mIBG imaging. (123)I-mIBG uptake was quantified as heart/mediastinum ratio on planar images (H/M p) and on SPECT images (H/M s) reconstructed by filtered backprojection, ordered subsets-expectation maximization (OSEM), and OSEM with compensation for collimator septal penetration (DSP). Relationships between age and (123)I-mIBG uptake were examined by correlation analysis, t-tests, and analysis of variance.
  
  
  RESULTS
  There was no significant correlation between age and H/M p, reflecting comparable increases in activity in the two regions of interest with age. Results on SPECT analyses were comparable, with no significant correlation between age and H/M s. Using DSP, (123)I-mIBG H/M s was significantly higher in subjects ≥70 of age compared with younger subjects.
  
  
  CONCLUSIONS
  Both cardiac and background uptake of (123)I-mIBG increase with age in older subjects without coronary heart disease, resulting in stability of H/M results (planar and SPECT). This study suggests that prognostic analyses of quantitative (123)I-mIBG uptake in patients with heart disease do not require adjustment for patient age.
authors.affiliation: Medical Diagnostics, GE Healthcare, 101 Carnegie Center, Princeton, NJ 08540, USA. arnold.jacobson@ge.com
authors.forename: Arnold F
authors.initials: AF
authors.lastname: Jacobson
authors.forename: Ji
authors.initials: J
authors.lastname: Chen
authors.forename: Liudmilla
authors.initials: L
authors.lastname: Verdes
authors.forename: Russell D
authors.initials: RD
authors.lastname: Folks
authors.forename: Daya N
authors.initials: DN
authors.lastname: Manatunga
authors.forename: Ernest V
authors.initials: EV
authors.lastname: Garcia
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000000981:diagnostic imaging; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D011857:Radiographic Image Interpretation, Computer-Assisted; D019275:Radiopharmaceuticals; D012016:Reference Values; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine; D013667:Technetium