title: Behavioral and corticotropic effects of ACTH during early postnatal ontogeny in rats.
abstract: ACTH1-24(1 mg/kg) administered to 5-7-day-old rats reduced their locomotor activity and did not alter blood levels of corticosterone. ACTH administration on postnatal days 12-14 increased corticosterone levels, but had no effect on locomotor activity. Thus, the behavioral effect of ACTH is not due to corticotropic action of the hormone and is not associated with blood levels of glucocorticoids.
authors.affiliation: Novosibirsk State University, and Laboratiry of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia. sheta@ngs.ru
authors.forename: T V
authors.initials: TV
authors.lastname: Shemenkova
authors.forename: T S
authors.initials: TS
authors.lastname: Kalinina
authors.forename: G T
authors.initials: GT
authors.lastname: Shishkina
authors.forename: N N
authors.initials: NN
authors.lastname: Dygalo
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D005938:Glucocorticoids / Q000097:blood; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone