title: Gross and fine motor skills in children treated for acute lymphoblastic leukaemia.
abstract: OBJECTIVE
  Chemotherapy treatment for acute lymphoblastic leukaemia (ALL) may disrupt motor development, with suggestions that gross and fine motor deficits are different depending on time since treatment.
  
  
  METHODS
  Thirty-seven participants aged between 2.5 to 5 years at the time of diagnosis were assessed using the Movement Assessment Battery for Children, 2nd Edition (MABC-2) and the Bruininks-Oseretsky Test of Motor Proficiency, 2nd Edition, Short Form (BOT-2 SF), and divided into groups (i.e., months-off-treatment): (1) 0-12, (2) 13-24, and (3) 25-60 for comparison.
  
  
  RESULTS
  MABC-2 and BOT-2 SF mean total scores fell within the average range. Twenty-six percent of the sample performed in the impaired range on the MABC-2. Group 2 had significantly lower Manual Dexterity scores than the normative population and lower BOT-2 SF scores than Group 1.
  
  
  CONCLUSIONS
  Most children treated for ALL display appropriate motor skills, yet around a quarter experience general motor difficulties. Time-off-treatment did not affect the prevalence of motor impairments on any measure.
authors.affiliation: Children's Cancer Centre, The Royal Children's Hospital, Melbourne, Australia.
authors.forename: Cinzia R
authors.initials: CR
authors.lastname: De Luca
authors.forename: Maria
authors.initials: M
authors.lastname: McCarthy
authors.forename: Jane
authors.initials: J
authors.lastname: Galvin
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Green
authors.forename: Alexandra
authors.initials: A
authors.lastname: Murphy
authors.forename: Sarah
authors.initials: S
authors.lastname: Knight
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Williams
mesh_terms: D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000502:physiology*; D011795:Surveys and Questionnaires