title: Dynamics of HIV type 1 recombination following superinfection.
abstract: There are currently few detailed studies describing HIV-1 recombination events or the potential impact of recombination on drug resistance. We describe here the viral recombination dynamics in a drug-naive patient initially infected with a circulating recombinant form 19 (CRF19) virus containing transmitted drug resistance mutations followed by superinfection with "wild-type" subtype B virus. Single genome analysis showed replacement of the primary CRF19 virus by recombinants of the CRF19 virus and the superinfecting subtype B virus. The CRF19/B recombinant virus dominating after superinfection had lost drug resistance mutations and at no time was the superinfecting subtype B variant found to be dominant in blood plasma. Furthermore, the detection of recombinant viruses in seminal plasma indicates the potential for onward transmission of these strains.
authors.affiliation: Virus Reference Department, Public Health England, London, UK. fransje.koning@phe.gov.uk
authors.forename: Fransje A
authors.initials: FA
authors.lastname: Koning
authors.forename: Anjna
authors.initials: A
authors.lastname: Badhan
authors.forename: Simon
authors.initials: S
authors.lastname: Shaw
authors.forename: Martin
authors.initials: M
authors.lastname: Fisher
authors.forename: Jean L
authors.initials: JL
authors.lastname: Mbisa
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Cane
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D024882:Drug Resistance, Viral / Q000235:genetics; D015658:HIV Infections / Q000235:genetics / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011995:Recombination, Genetic / Q000235:genetics*; D015163:Superinfection / Q000235:genetics / Q000821:virology*; D013997:Time Factors; D019562:Viral Load / Q000235:genetics