title: Too much or too little, how much HDAC activity is good for you?
abstract: In this issue of Blood, Heideman and colleagues show that the major class I histone deacetylases (HDACs) HDAC1 and HDAC2 can act to suppress tumors in mouse thymocytes.
authors.affiliation: Friedrich Miescher Institute For Biomedical Research, Switzerland.
authors.forename: Patrick
authors.initials: P
authors.lastname: Matthias
mesh_terms: D000818:Animals; D018628:Gene Dosage / Q000502:physiology*; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D056284:Histone Deacetylase 1 / Q000235:genetics*; D056464:Histone Deacetylase 2 / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: C489428:Myc protein, mouse; D016271:Proto-Oncogene Proteins c-myc; D016159:Tumor Suppressor Protein p53; C484389:Hdac1 protein, mouse; C533424:Hdac2 protein, mouse; D056284:Histone Deacetylase 1; D056464:Histone Deacetylase 2