title: Effect of antibodies to glutamate on caspase-3 activity in brain structures of rats with experimental Alzheimer's disease.
abstract: Experiments on rats have showed that neurodegenerative damage to the brain induced by injection of a neurotoxic β-amyloid protein fragment β25-35into the basal giant cell nuclei of Meynert activated caspase-3 in the prefrontal cortex and hippocampus on day 3 after injury. Intranasal administration of antibodies to glutamate in a dose of 300 μ g/kg 1 h after damage reduced enzyme activity in these structures in a rat model of Alzheimer's disease.
authors.affiliation: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. f.neurochemistry@gmail.com
authors.forename: V V
authors.initials: VV
authors.lastname: Kolobov
authors.forename: I A
authors.initials: IA
authors.lastname: Zakharova
authors.forename: V G
authors.initials: VG
authors.lastname: Fomina
authors.forename: V Yu
authors.initials: VY
authors.lastname: Gorbatov
authors.forename: T V
authors.initials: TV
authors.lastname: Davydova
mesh_terms: D000281:Administration, Intranasal; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000201:enzymology*; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D053148:Caspase 3 / Q000378:metabolism*; D018698:Glutamic Acid / Q000276:immunology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000906:Antibodies; D018698:Glutamic Acid; D053148:Caspase 3