title: Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment.
abstract: In the quest for novel tools for early detection and treatment of cancer, we propose the use of multimers targeting overexpressed receptors at the cancer cell surface. Indeed, multimers are prone to create multivalent interactions, more potent and specific than their corresponding monovalent versions, thus enabling the potential for early detection. There is a lack of tools for early detection of pancreatic cancer, one of the deadliest forms of cancer, but CCK2-R overexpression on pancreatic cancer cells makes CCK based multimers potential markers for these cells. In this Letter, we describe the synthesis and evaluation of CCK trimers targeting overexpressed CCK2-R.
authors.affiliation: UPMC Paris 06, UMR 7203, Laboratoire des BioMolécules, Université P et M Curie, 75005 Paris, France.
authors.forename: Nabila
authors.initials: N
authors.lastname: Brabez
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Nguyen
authors.forename: Kara
authors.initials: K
authors.lastname: Saunders
authors.forename: Ryan
authors.initials: R
authors.lastname: Lacy
authors.forename: Liping
authors.initials: L
authors.lastname: Xu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Gillies
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Lynch
authors.forename: Gerard
authors.initials: G
authors.lastname: Chassaing
authors.forename: Solange
authors.initials: S
authors.lastname: Lavielle
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Hruby
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000737:chemistry; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D011949:Receptors, Cholecystokinin / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin