title: Effects of heat-killed Lactobacillus pentosus S-PT84 on postprandial hypertriacylglycerolemia in rats.
abstract: The effect of Lactobacillus pentosus strain S-PT84 (S-PT84) on postprandial hypertriacylglycerolemia was investigated in rats. S-PT84 dose-dependently inhibited the hydrolysis of triacylglycerols by pancreatic lipase in vitro. Intragastric administration of S-PT84 significantly reduced the lymphatic recovery of (3)H-trioleoylglycerol up to 8 h. The oral administration of a fat emulsion, with or without S-PT84, resulted in the concentration of plasma triacylglycerol 2 h and 3 h after administration being significantly lower in the S-PT84 group than in the group without S-PT84 (control group). These results suggest that S-PT84 alleviated postprandial hypertriacylglycerolemia by delaying triacylglycerol absorption in the intestine through the inhibition of pancreatic lipase.
authors.affiliation: Laboratory of Food and Biomolecular Science, Graduate School of Agriculture Science, Tohoku University, Sendai, Japan.
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Zhou
authors.forename: Nao
authors.initials: N
authors.lastname: Inoue
authors.forename: Ran
authors.initials: R
authors.lastname: Ozawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Maekawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Izumo
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kiso
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibata
authors.forename: Ikuo
authors.initials: I
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D006358:Hot Temperature; D015228:Hypertriglyceridemia / Q000378:metabolism / Q000382:microbiology*; D007778:Lactobacillus / Q000502:physiology*; D008049:Lipase / Q000378:metabolism; D008196:Lymph / Q000378:metabolism; D008297:Male; D050296:Microbial Viability; D010179:Pancreas / Q000201:enzymology; D019518:Postprandial Period; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000378:metabolism
chemical_list: D014280:Triglycerides; D008049:Lipase