title: Aphanamgrandiol A, a new triterpenoid with a unique carbon skeleton from Aphanamixis grandifolia.
abstract: Aphanamgrandiol A (1), a novel triterpenoid with a bicyclo[3,2,1]octane ring skeleton produced by 2,3-ring opening and 2,6-ring closure, was isolated from the stems of Aphanamixis grandifolia. The structures were established on the basis of extensive spectroscopic methods, including 1D and 2D NMR techniques, and determined unambiguously by X-ray crystal diffraction. Aphanamgrandiol A showed moderate cytotoxicities against MCG-803, SKOV-3, HCT116 and HepG2 cell lines.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zeng
authors.forename: Bin
authors.initials: B
authors.lastname: Guan
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: Wang
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Cheng
authors.forename: Jiang-Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Hui Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D002244:Carbon / Q000737:chemistry; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes; C584385:aphanamgrandiol A; D002244:Carbon