title: [Assessment of the MF59-adjuvanted pandemic influenza A/H1N1 vaccine. Systematic review of literature].
abstract: OBJECTIVE
  To assess the efficacy and safety of MF59-adjuvanted pandemic influenza A/H1N1 vaccine in children.
  
  
  METHODS
  A systematic review of the literature was performed after searching the MedLine and Embase electronic databases, and manual search in specialties journals, with MeSH terms and and free terms. Inclusion criteria were clinical trials with children vaccinated with MF59-adjuvanted influenza A/H1N1 vaccine, compared with other vaccines doses with/without MF59-adjuvanted. The immunogenicity and safety of the vaccine was recorded. The quality of the studies included was assessed by CASPe checklist.
  
  
  RESULTS
  Four clinical trials with moderate quality were selected. The local and systemic adverse effects were rare and mild, with no differences between groups. Seroconversion and seroprotection levels were higher with MF59-adjuvanted vaccines. Antibody titres were also higher with the adjuvant vaccines.
  
  
  CONCLUSIONS
  The adjuvant vaccine has a good efficacy and safety profile. The adverse effects that may occur are common and appear similarly in both vaccination groups.
authors.affiliation: Grupo de Investigación Enfermedades Infecciosas Pediátricas, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address: jesusm.ruiz.ext@juntadeandalucia.es.
authors.forename: J
authors.initials: J
authors.lastname: Ruiz-Aragón
authors.forename: A M
authors.initials: AM
authors.lastname: Grande Tejada
authors.forename: S
authors.initials: S
authors.lastname: Márquez-Peláez
authors.forename: J M
authors.initials: JM
authors.lastname: Molina Linde
authors.forename: R
authors.initials: R
authors.lastname: Yang
mesh_terms: D000276:Adjuvants, Immunologic; D002648:Child; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control*; D058873:Pandemics; D011136:Polysorbates; D013185:Squalene
chemical_list: D000276:Adjuvants, Immunologic; D007252:Influenza Vaccines; C089950:MF59 oil emulsion; D011136:Polysorbates; D013185:Squalene
keywords: Efficacy; Eficacia; Influenza A virus H1N1 subtype; Revisión sistemática; Safety; Seguridad; Systematic review; Vacuna pandémica A/H1N1