title: Professor Thomas Lehner: archetypal translational scientist.
abstract: Professor Thomas Lehner is one of the most distinguished oral and dental researchers to have come out of the UK. Over the past 40 years, he has made an astonishing number of discoveries which have had an impact on our understanding of the pathogenesis of a variety of mucosal diseases. He has consistently practiced both basic and clinical research and built an integrated group of clinical and non-clinical researchers, which allowed him easy transition from the laboratory to the clinic. Tom Lehner was among the early scientists studying mucosal immunology, initially exploring oral diseases, with special emphasis on the immunobiology of Streptococcus mutans, leading to active and passive vaccination against dental caries. He was the first to demonstrate cellular immunity as the immunopathological basis of periodontal diseases, recurrent aphthous stomatitis, and candidiasis. Over the past 20 years, his expertise in mucosal immunobiology has been applied to the immunology of HIV/SIV infections. His seminal contributions include regional innate mucosal immunity, prevention of SIV infection in macaques by secretory IgA antibodies, up-regulation of CC chemokines, and the first demonstration of protective CCR5 antibodies. Arguably, his leadership, his students, and the establishment of immunology applied to oral mucosal diseases will be his greatest legacy. His contributions continue unabated.
authors.affiliation: King's College London Dental Institute at Guys Hospital, London SE1 9RT, UK. stephen.challacombe@kcl.ac.uk
authors.forename: S J
authors.initials: SJ
authors.lastname: Challacombe
mesh_terms: D003731:Dental Caries / Q000276:immunology* / Q000517:prevention & control; D018865:Dental Research / Q000266:history; D015658:HIV Infections / Q000276:immunology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009061:Mouth Mucosa / Q000276:immunology*; D010510:Periodontal Diseases / Q000266:history / Q000276:immunology*; D013295:Streptococcus mutans / Q000276:immunology*; D057170:Translational Research, Biomedical / Q000266:history*; D006113:United Kingdom; D014611:Vaccination / Q000266:history