title: Phenolic constituents from the twigs of Euonymus alatus and their cytotoxic and anti-inflammatory activity.
abstract: A bioassay-guided fractionation and chemical investigation of the MeOH extract of the twigs of Euonymus alatus resulted in the isolation and identification of five new phenolic compounds, named alatusols A-E (1-5), together with six known compounds (6-11). The structures of these new compounds were elucidated through spectral analysis, including extensive 2D-NMR data, and their absolute configurations were determined by the modified Mosher's method. Compounds 1-3 and 7-9 showed consistent cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values of 15.20-29.81 µM. In addition, compounds 5 and 7 inhibited nitric oxide production in lipopolysaccharide-activated BV-2 cells with IC50 values of 22.77 and 32.52 µM, respectively.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Sang Keun
authors.initials: SK
authors.lastname: Ha
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D029756:Euonymus / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D010636:Phenols