title: Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract.
abstract: A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.
authors.affiliation: Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
authors.forename: Gary V
authors.initials: GV
authors.lastname: Martinez
authors.forename: Suryakiran
authors.initials: S
authors.lastname: Navath
authors.forename: Kamini
authors.initials: K
authors.lastname: Sewda
authors.forename: Venkataramanarao
authors.initials: V
authors.lastname: Rao
authors.forename: Parastou
authors.initials: P
authors.lastname: Foroutan
authors.forename: Ramesh
authors.initials: R
authors.lastname: Alleti
authors.forename: Valerie E
authors.initials: VE
authors.lastname: Moberg
authors.forename: Ali M
authors.initials: AM
authors.lastname: Ahad
authors.forename: Domenico
authors.initials: D
authors.lastname: Coppola
authors.forename: Mark C
authors.initials: MC
authors.lastname: Lloyd
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Gillies
authors.forename: David L
authors.initials: DL
authors.lastname: Morse
authors.forename: Eugene A
authors.initials: EA
authors.lastname: Mash
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000737:chemistry; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D051379:Mice; D008809:Mice, Inbred C3H; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry; D013395:Sucrose / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D013395:Sucrose; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate