title: Characterising neurological time series data using biologically motivated networks of coupled discrete maps.
abstract: Artificial biochemical networks (ABNs) are a class of computational dynamical system whose architectures are motivated by the organisation of genetic and metabolic networks in biological cells. Using evolutionary algorithms to search for networks with diagnostic potential, we demonstrate how ABNs can be used to carry out classification when stimulated with time series data collected from human subjects with and without Parkinson's disease. Artificial metabolic networks, composed of coupled discrete maps, offer the best recognition of Parkinsonian behaviour, achieving accuracies in the region of 90%. This is comparable to the diagnostic accuracies found in clinical diagnosis, and is significantly higher than those found in primary and non-expert secondary care. We also illustrate how an evolved classifier is able to recognise diverse features of Parkinsonian behaviour and, using perturbation analysis, show that the evolved classifiers have interesting computational behaviours.
authors.affiliation: Department of Electronics, University of York, Heslington, York YO10 5DD, UK. michael.lones@york.ac.uk
authors.forename: Michael A
authors.initials: MA
authors.lastname: Lones
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Smith
authors.forename: Andy M
authors.initials: AM
authors.lastname: Tyrrell
authors.forename: Jane E
authors.initials: JE
authors.lastname: Alty
authors.forename: D R Stuart
authors.initials: DR
authors.lastname: Jamieson
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D008959:Models, Neurological; D016571:Neural Networks, Computer; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity