title: Acute alcohol intoxication in adolescents: frequency of respiratory depression.
abstract: BACKGROUND
  Adolescents and young adults are frequent users of alcohol. Younger patients may be more sensitive to the effects of alcohol than their adult counterparts, and toxicity has been known to occur at lower doses. Respiratory depression is a serious adverse effect of alcohol intoxication; however, current monitoring practices may not adequately detect respiratory depression.
  
  
  OBJECTIVE
  Our objective was to determine the frequency of hypoventilation as measured by capnography among adolescents with acute alcohol intoxication. Our secondary objective was to determine if an association exists between alcohol levels and incidence of hypoventilation.
  
  
  METHODS
  This was a prospective observational pilot study of patients 14-20 years of age with acute alcohol intoxication. Blood or breath alcohol measurements were obtained on arrival. Hourly measurements of vital signs including capnography were recorded.
  
  
  RESULTS
  Sixty-five subjects were analyzed. Mean alcohol level was 185 mg/dL. Twenty-eight percent of subjects had episodes of hypoventilation. Episodes occurred in similar proportions on arrival and during the first 5 h of measurements. There was no difference in alcohol levels between subjects who did and did not hypoventilate (185 mg/dL vs. 186 mg/dL; 95% confidence interval -29 to 25). Oxygen desaturations occurred in 14 subjects and were associated with hypoventilation (p = 0.015).
  
  
  CONCLUSIONS
  Hypoventilation is common among adolescents who are acutely intoxicated with alcohol. It is independent of alcohol level and occurs at a steady rate during the first several hours of intoxication. Capnography should be considered as an additional monitoring device to detect these episodes and enhance patient safety.
authors.affiliation: Department of Pediatrics, Section of Emergency Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Langhan
mesh_terms: D000293:Adolescent; D000435:Alcoholic Intoxication / Q000097:blood / Q000453:epidemiology*; D019296:Capnography; D002492:Central Nervous System Depressants / Q000097:blood; D004636:Emergency Service, Hospital; D000431:Ethanol / Q000097:blood; D005260:Female; D006801:Humans; D007040:Hypoventilation / Q000453:epidemiology*; D008297:Male; D010092:Oximetry; D010100:Oxygen / Q000097:blood; D010865:Pilot Projects; D011446:Prospective Studies; D019037:Urban Health Services; D055986:Vital Signs; D055815:Young Adult
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol; D010100:Oxygen