title: Autotransplantation or replantation of cryopreserved teeth: a case series and literature review.
abstract: The aim of this report was to evaluate the outcome of autotransplantation or replantation of cryopreserved teeth clinically and radiographically. Donor teeth were slowly frozen in a controlled-rate freezer using 5% dimethylsulfoxide (DMSO) and 6% hydroxyethyl starch (HES) as protectants. Seven cryopreserved teeth, with duration of storage ranging from 4 to 36 months, were autotransplanted or replanted at Niigata University Medical and Dental Hospital. Endodontic treatment involving root canal debridement followed by interim root canal filling with calcium hydroxide was started 3 weeks after the operation and continued with replacement of the calcium hydroxide filling at 2-week to 3-month intervals. Three transplants showed periodontal regeneration clinically and radiographically, whereas replacement root resorption was observed in the remaining transplants. From the results, it can be concluded that cryopreserved tooth autotransplantation has potential for clinical use; however, the risk of replacement root resorption remains.
authors.affiliation: Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Yoshizawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Koyama
authors.forename: Naoya
authors.initials: N
authors.lastname: Izumi
authors.forename: Kanae
authors.initials: K
authors.lastname: Niimi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ono
authors.forename: Hisao
authors.initials: H
authors.lastname: Ajima
authors.forename: Akinori
authors.initials: A
authors.lastname: Funayama
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Mikami
authors.forename: Tadaharu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ono
authors.forename: Ritsuo
authors.initials: R
authors.lastname: Takagi
authors.forename: Chikara
authors.initials: C
authors.lastname: Saito
mesh_terms: D000293:Adolescent; D000328:Adult; D002126:Calcium Hydroxide / Q000008:administration & dosage; D015925:Cryopreservation; D004708:Endodontics; D005260:Female; D006801:Humans; D008297:Male; D014090:Tooth Replantation / Q000009:adverse effects / Q000379:methods*; D014182:Transplantation, Autologous / Q000009:adverse effects / Q000379:methods*; D055815:Young Adult
chemical_list: D002126:Calcium Hydroxide
keywords: autotransplantation; cryopreservation; replantation; tooth