title: Neuropsychiatric disease in patients with periventricular heterotopia.
abstract: Periventricular heterotopia (PH) is a disorder of neuronal migration. Previous clinical reports of PH have largely focused on the seizure-related and neurodevelopmental consequences of this condition. The authors report four unrelated individuals with PH, with particular emphasis on their behavioral and psychiatric morbidity. A review of the literature suggests that neuropsychiatric presentations are an underrecognized consequence of PH. Clinicians need to be alert to psychiatric complications associated with PH and related disorders of neuronal migration.
authors.affiliation: Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK. Fry2@wales.nhs.uk
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Fry
authors.forename: Michael P
authors.initials: MP
authors.lastname: Kerr
authors.forename: Frances
authors.initials: F
authors.lastname: Gibbon
authors.forename: Peter D
authors.initials: PD
authors.lastname: Turnpenny
authors.forename: Khalid
authors.initials: K
authors.lastname: Hamandi
authors.forename: Neil
authors.initials: N
authors.lastname: Stoodley
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Robertson
authors.forename: Daniela T
authors.initials: DT
authors.lastname: Pilz
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D001523:Mental Disorders / Q000150:complications*; D054091:Periventricular Nodular Heterotopia / Q000150:complications*; D055815:Young Adult