title: The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes.
abstract: OBJECTIVE
  To determine the impact of histological chorioamnionitis (HCA) and funisitis on neonatal outcome in preterm prelabor rupture of membranes (PPROM) pregnancies.
  
  
  METHODS
  Women with PPROM between 24 + 0 to 36 + 6 weeks of gestation, admitted to the Department of Obstetrics and Gynecology at the University Hospital Hradec Kralove in the Czech Republic, between July 2008 and October 2010, were enrolled in the study (n = 231).
  
  
  RESULTS
  The incidence of early-onset sepsis (EOS) differed significantly in neonates born to women with and without HCA, after adjustment for gestational age (11% versus 1%, p = 0.011). The incidence of EOS in neonates was also significantly different, after adjustment for gestational age, in cases with and without funisitis (18% versus 4%, p = 0.002). The same was also found for retinopathy of prematurity (ROP) cases with and without funisitis (23% versus 4%, p = 0.014), after adjustment for gestational age.
  
  
  CONCLUSIONS
  HCA and funisitis increase the risk of adverse perinatal outcome in PPROM pregnancies.
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden. tsiartaspanos@gmail.com
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Tsiartas
authors.forename: Marian
authors.initials: M
authors.lastname: Kacerovsky
authors.forename: Ivana
authors.initials: I
authors.lastname: Musilova
authors.forename: Helena
authors.initials: H
authors.lastname: Hornychova
authors.forename: Teresa
authors.initials: T
authors.lastname: Cobo
authors.forename: Karin
authors.initials: K
authors.lastname: Sävman
authors.forename: Bo
authors.initials: B
authors.lastname: Jacobsson
mesh_terms: D000328:Adult; D002821:Chorioamnionitis / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D055815:Young Adult