title: "Clickable" hydrosoluble PEGylated cryptophane as a universal platform for 129Xe magnetic resonance imaging biosensors.
abstract: We describe the synthesis of a highly water-soluble cryptophane 1 that can be seen as a universal platform for the construction of (129)Xe magnetic resonance imaging (MRI)-based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon-encapsulation properties. In addition, 1 is nontoxic at the concentrations typically used for hyperpolarized (129)Xe MRI.
authors.affiliation: iBiTecS, Service de Chimie Bioorganique et de Marquage (SCBM), CEA, 91191 Gif-sur-Yvette, France.
authors.forename: Léa
authors.initials: L
authors.lastname: Delacour
authors.forename: Naoko
authors.initials: N
authors.lastname: Kotera
authors.forename: Ténin
authors.initials: T
authors.lastname: Traoré
authors.forename: Sébastien
authors.initials: S
authors.lastname: Garcia-Argote
authors.forename: Céline
authors.initials: C
authors.lastname: Puente
authors.forename: François
authors.initials: F
authors.lastname: Leteurtre
authors.forename: Edmond
authors.initials: E
authors.lastname: Gravel
authors.forename: Nawal
authors.initials: N
authors.lastname: Tassali
authors.forename: Céline
authors.initials: C
authors.lastname: Boutin
authors.forename: Estelle
authors.initials: E
authors.lastname: Léonce
authors.forename: Yves
authors.initials: Y
authors.lastname: Boulard
authors.forename: Patrick
authors.initials: P
authors.lastname: Berthault
authors.forename: Bernard
authors.initials: B
authors.lastname: Rousseau
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D057930:Click Chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011083:Polycyclic Compounds / Q000737:chemistry*; D014867:Water; D014978:Xenon / Q000737:chemistry*
chemical_list: D011083:Polycyclic Compounds; C523242:cryptophane; D014867:Water; D014978:Xenon