title: Assembly of spirooxindole derivatives containing four consecutive stereocenters by using cascade reactions catalyzed by an N-heterocyclic carbene.
abstract: In-spiro-ational: Biologically important and synthetically challenging spirocyclopentaneoxindoles with four consecutive stereocenters, including one spiroquaternary stereocenter, have been constructed in good yields and diastereoselectivity by a cascade reaction catalyzed by an N-heterocyclic carbene (see scheme). This reaction also provides a new strategy to access highly unusual tricyclic oxindoles.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, PR China. zhoubing2012@hotmail.com
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.forename: Zhi
authors.initials: Z
authors.lastname: Luo
authors.forename: Yuanchao
authors.initials: Y
authors.lastname: Li
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D000078183:Oxindoles; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D007211:Indoles; D000078183:Oxindoles; D013141:Spiro Compounds; C022960:2-oxindole; C030011:carbene; D008697:Methane