title: The prognostic value of platelet endothelial cell adhesion molecule-1 in non-small-cell lung cancer patients.
abstract: Our previous studies have shown that platelet endothelial cell adhesion molecule-1 (PECAM-1), a member of the immunoglobulin superfamily, is a critical mediator of anchorage-independent growth and anoikis resistance in lung carcinoma cells. The purpose of this study was to analyze the protein expression of PECAM-1 in non-small-cell lung carcinoma (NSCLC) tissues and its clinical significance in NSCLC patients. By immunohistochemical analysis, high microvessel density (MVD) of PECAM-1 was detected in the stromal tissues of NSCLC. The MVD of PECAM-1 was strongly correlated with the N stage (p = 0.029), M stage (p = 0.001) and clinical stage (p = 0.001) of NSCLC patients. Survival analysis revealed high MVD of PECAM-1 in both primary NSCLC lesions and metastatic lymph node tissues, and these results were found to be significantly correlated with poor overall survival in NSCLC patients (p < 0.001 and p = 0.021, respectively). Moreover, patients with high PECAM-1 MVD had worse overall survival in either adenocarcinoma or EGFR mutation subgroups. Multivariate analysis revealed that the MVD of PECAM-1 was an independent prognostic factor for NSCLC patients. The MVD of PECAM-1 is also a potential predictor for NSCLC patients treated with first-line platinum-based doublet chemotherapy, as high PECAM-1 MVD correlated with worse overall survival. Our results demonstrated that MVD of PECAM-1 could be a potential prognostic factor and therapeutic target in NSCLC.
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, 651 East Dongfeng Road, Guangzhou 510060, China.
authors.forename: Bo-hua
authors.initials: BH
authors.lastname: Kuang
authors.forename: Xi-zhi
authors.initials: XZ
authors.lastname: Wen
authors.forename: Ya
authors.initials: Y
authors.lastname: Ding
authors.forename: Rui-qing
authors.initials: RQ
authors.lastname: Peng
authors.forename: Pei-qiang
authors.initials: PQ
authors.lastname: Cai
authors.forename: Meng-qing
authors.initials: MQ
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.forename: Xiao-shi
authors.initials: XS
authors.lastname: Zhang
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D008297:Male; D055806:Microvessels / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000096:biosynthesis / Q000502:physiology*; D011379:Prognosis; D015996:Survival Rate / Q000639:trends
chemical_list: D014408:Biomarkers, Tumor; D019408:Platelet Endothelial Cell Adhesion Molecule-1