title: Phenotypic subgroups of polycystic ovary syndrome have different intra-renal resistance symptoms.
abstract: OBJECTIVE
  The polycystic ovary syndrome (PCOS) is known to be related with increased metabolic and cardiovascular risks. Various phenotypic subgroups of PCOS have been proven to have metabolic and endocrine disorders with varying degrees of severity However, intra-renal vascular resistance, which is an indirect indication of atherosclerosis, remains unknown in PCOS subgroups. In this study we examined whether PCOS subgroups have different intra-renal resistance symptoms.
  
  
  METHODS
  98 PCOS patients (diagnosed according to the Rotterdam criteria) 30 controls were included in the study The diagnosis of PCOS was established in the presence of at least two of the following criteria: 1-oligo and/or amenorrhea (OM); 2-clinic and/or biochemical signs of hyperandrogenism (HA); 3-polycystic ovarian morphology (PCO) detected by transvaginal ultrasonography 37 patients (Group 1) met all three criteria (HA+OM+PCO), 29 patients (Group 2) met two of the criteria including hyperandrogenism (HA+OM or HA+PCO) and the remaining 32 patients (Group 3) had no hyperandrogenism but fulfilled the other two criteria; PCO+OM. Renal Doppler ultrasonography and hormonal/biochemical analyses were carried out. The first outcome measure was designated as the differences in the renal resistive index (RRI) values of the groups, and the second outcome measure was designated as the relation of RRI with the insulin resistance and lipid profile.
  
  
  RESULTS
  In Group 1, the RRI and the homeostasis model assessment of insulin resistance (HOMA-IR) values were significantly higher than in Group 3 and controls (P < 0.031, P < 0.001, respectively after adjusting for age and BMI). The RRI and HOMA-IR values in Group 3 were similar to those of the control group. It was determined that RRI has a positive correlation with HOMA-IR (r = 0.784, P < .0001) and BMI (r = 0.645, P < .0001).
  
  
  CONCLUSIONS
  In this study we demonstrated that PCOS subgroups have metabolic and endocrine disorders and cardiovascular risks of varying degrees of severity Moreover, we showed that there was no increase of metabolic and cardiovascular risks in PCOS patients without hyperandrogenism.
authors.affiliation: Department of Obstetrics and Gynecology, Baskent University Faculty of Medicine, Konya, Turkey.
authors.forename: Ceylan F
authors.initials: CF
authors.lastname: Ciftci
authors.forename: Ayla
authors.initials: A
authors.lastname: Uckuyu
authors.forename: Elif
authors.initials: E
authors.lastname: Karadeli
authors.forename: Erdem
authors.initials: E
authors.lastname: Turhan
authors.forename: Erzat
authors.initials: E
authors.lastname: Toprak
authors.forename: Emel E
authors.initials: EE
authors.lastname: Ozcimen
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology*; D016022:Case-Control Studies; D004700:Endocrine System Diseases / Q000209:etiology*; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000209:etiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D018616:Ultrasonography, Doppler, Duplex; D014655:Vascular Resistance