title: Regulation of intestinal homeostasis and immunity with probiotic lactobacilli.
abstract: The gut microbiota provide important stimuli to the human innate and adaptive immune system and co-mediate metabolic and immune homeostasis. Probiotic bacteria can be regarded as part of the natural human microbiota, and have been associated with improving homeostasis, albeit with different levels of success. Composition of microbiota, probiotic strain identity, and host genetic differences may account for differential modulation of immune responses by probiotics. Here, we review the mechanisms of immunomodulating capacities of specific probiotic strains, the responses they can induce in the host, and how microbiota and genetic differences between individuals may co-influence host responses and immune homeostasis.
authors.affiliation: Host Microbe Interactomics Group, Wageningen University, De Elst 1, 6708WD Wageningen, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: van Baarlen
authors.forename: Jerry M
authors.initials: JM
authors.lastname: Wells
authors.forename: Michiel
authors.initials: M
authors.lastname: Kleerebezem
mesh_terms: D000818:Animals; D059647:Gene-Environment Interaction; D006706:Homeostasis / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D018928:Immunity, Mucosal; D056747:Immunomodulation; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000382:microbiology* / Q000628:therapy; D007422:Intestines / Q000276:immunology* / Q000382:microbiology; D007778:Lactobacillus / Q000276:immunology*; D064307:Microbiota / Q000276:immunology*; D019936:Probiotics