title: R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla.
abstract: A number of single gene mutations in laboratory mice produce hair follicle defects resulting in deformed hair shafts. The radiation-induced (SB/LeJ-Foxq1(sa)) satin mutant mice have a satin-like sheen to their hair and dilute colouration. This sheen is due to failure of the hair shafts to develop normal medullas, while the pigment dilution is due to the unrelated beige (lysosomal trafficking regulator, Lyst(bg)) mutation. A new allelic mutation, Foxq1(sa-J), arose spontaneously on the albino (tyrosinase, Tyr(c)) MRL/MpJ-Fas(lpr) background. The Foxq1(sa-J) allele has a C to T transition at position 490. By contrast, the Foxq1(sa) mutant allele was confirmed to be a 67 base pair deletion followed by two base changes (GA to AT). Morphologic changes were similar to those seen in Hoxc13 transgenic and targeted mutant mice. This new allelic mutation provides yet another tool to investigate formation of the interior structures of hair shafts.
authors.forename: Baojin
authors.initials: B
authors.lastname: Wu
authors.forename: C
authors.initials: C
authors.lastname: Herbert Pratt
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Potter
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Silva
authors.forename: Vicki
authors.initials: V
authors.lastname: Kennedy
authors.forename: John P
authors.initials: JP
authors.lastname: Sundberg
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D051858:Forkhead Transcription Factors / Q000032:analysis / Q000235:genetics*; D006200:Hair Color / Q000235:genetics*; D018859:Hair Follicle / Q000196:embryology*; D051379:Mice; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D023421:Models, Animal; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D010641:Phenotype
chemical_list: D051858:Forkhead Transcription Factors; C107579:Foxq1 protein, mouse