title: Water-solid interactions in amorphous maltodextrin-crystalline sucrose binary mixtures.
abstract: Amorphous and crystalline solids are commonly found together in a variety of pharmaceutical and food products. In this study, the influence of co-formulation of amorphous maltodextrins (MDs) and crystalline sucrose (S) on moisture sorption, deliquescence, and glass transition (Tg) properties of powder blends was investigated. Individual components and binary mixtures of four different molecular weight MDs with sucrose in 1:1 w/w ratios were exposed to various relative humidity (RH) environments and their equilibrium and dynamic moisture contents were monitored. The deliquescence point (RH0) and dissolution behavior of sucrose alone and in blends was also monitored by polarized light microscopy and second harmonic generation imaging. In S:MD blends, the deliquescence RH of sucrose was lower than the RH0 of sucrose alone, and synergistic moisture sorption also occurred at RHs lower than the RH0. Intimate contact of sucrose crystals with the amorphous MDs resulted in complete dissolution of sucrose at RH < RH0. When blends were stored at conditions exceeding the Tg of the individual MDs (25 °C and 60%, 49% and 34%RH for MD21, MD29 and MD40, respectively), the Tg of the blends was lower than that of individual MDs. Thus, co-formulation of amorphous MDs with crystalline sucrose sensitizes the blend to moisture, potentially leading to deleterious changes in the formulation if storage conditions are not adequately controlled.
authors.affiliation: Department of Industrial and Physical Pharmacy .
authors.forename: Mohamed K
authors.initials: MK
authors.lastname: Ghorab
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Toth
authors.forename: Garth J
authors.initials: GJ
authors.lastname: Simpson
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Mauer
authors.forename: Lynne S
authors.initials: LS
authors.lastname: Taylor
mesh_terms: D003460:Crystallization; D006813:Humidity; D011134:Polysaccharides / Q000737:chemistry*; D013395:Sucrose / Q000737:chemistry*; D044366:Transition Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D011134:Polysaccharides; D014867:Water; D013395:Sucrose; C008315:maltodextrin