title: [Clinical and immunological features of acute hepatitis B in patients with concomitant chronic toxic liver damage].
abstract: The article presents information obtained during the survey in 64 patients with acute hepatitis B. We show that acute hepatitis B in patients with concomitant chronic toxic liver characterized by a marked imbalance of cytokine status due to a lower level of interleukin-2 and a higher content of interleukin-8, the highest levels of nitrite content, spontaneous oxidative modifications of blood proteins and the lowest content of L -arginine in the blood serum in the dynamics of disease compared with patients without this concomitant factor. In the period of convalescence these changes in patients with acute hepatitis B with concomitant chronic toxic liver characterized combined with higher cytolysis of liver cells, often circulating in the blood of HBsAg seroconversion and less frequently with the advent of anti-HBeAg.
authors.affiliation: Zaporozhye State Medical University, Zaporozhye, Ukraine.
authors.forename: E
authors.initials: E
authors.lastname: Furyk
authors.forename: E
authors.initials: E
authors.lastname: Ryabokon
mesh_terms: D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins; D005260:Female; D006509:Hepatitis B / Q000097:blood* / Q000150:complications / Q000473:pathology; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000097:blood / Q000276:immunology; D006515:Hepatitis B virus / Q000472:pathogenicity; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008099:Liver / Q000293:injuries* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010802:Phylogeny
chemical_list: D001798:Blood Proteins; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D007376:Interleukin-2; D016209:Interleukin-8