title: Thymic stromal lymphopoietin over-expressed in human atherosclerosis: potential role in Th17 differentiation.
abstract: BACKGROUND
  Adaptive immunity plays a critical role in atherosclerosis and T helper 17 (Th17) cells, a new T-cell lineage, are recently reported to be involved in atherosclerosis. However, the mechanism underlying Th17 inflammation in atherosclerosis remains largely unknown. Thymic stromal lymphopoietin (TSLP) is a novel IL-7-like cytokine and mainly responsible for Th2 inflammation in many inflammatory diseases.
  
  
  RESULTS
  Immunohistochemistry showed that TSLP over-expressed in human atherosclerotic lesion and could be induced by ox-LDL in human vascular smooth muscle cells (HVSMCs) and human umbilical vein endothelial cells (HUVECs). TSLP, in turn, could activate dendritic cells (DCs) to differentiate Th17 inflammation in naive CD4(+) T cells.
  
  
  CONCLUSIONS
  TSLP induced by ox-LDL could promote Th17 immune response in vitro, which may be implicated in Th17 inflammation in atherosclerosis.
authors.affiliation: Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.forename: Wei
authors.initials: W
authors.lastname: Chang
authors.forename: Jiangchuan
authors.initials: J
authors.lastname: Dong
authors.forename: Fengxiao
authors.initials: F
authors.lastname: Zhang
authors.forename: Nilesh
authors.initials: N
authors.lastname: Mohabeer
authors.forename: Kishan Kumar
authors.initials: KK
authors.lastname: Kushwaha
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Yousu
authors.initials: Y
authors.lastname: Su
authors.forename: Hongcheng
authors.initials: H
authors.lastname: Fang
authors.forename: Dazhu
authors.initials: D
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation; D002478:Cells, Cultured; D018920:Coculture Techniques; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D003713:Dendritic Cells / Q000166:cytology; D005260:Female; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007150:Immunohistochemistry; D008077:Lipoproteins, LDL / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction; D058504:Th17 Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D008077:Lipoproteins, LDL; D050796:STAT3 Transcription Factor; C099252:oxidized low density lipoprotein; D000094632:Thymic Stromal Lymphopoietin