title: Over-expression of Metastasis-associated in Colon Cancer-1 (MACC1) Associates with Better Prognosis of Gastric Cancer Patients.
abstract: OBJECTIVE
  The aim of this study was to detect metastasis-associated in colon cancer-1 (MACC1) expression in Chinese gastric cancer and analyze the relationship between MACC1 expression and postoperative survival.
  
  
  METHODS
  The expression of MACC1 and c-MET protein in a sample of 128 gastric cancer tissues was detected by immunohistochemistry. A retrospective cohort study on the prognosis was carried out and data were collected from medical records.
  
  
  RESULTS
  The positive rate of MACC1 protein expression in gastric cancer was 47.66%, higher than that in adjacent noncancerous mucosa (P<0.001). MACC1 protein expression was not related to the clinicopathological variables involved. Kaplan-Meier analysis revealed that the survival of MACC1 positive group tended to be better than that of MACC1 negative group, particularly in patients with stage III carcinoma (P=0.032). Cox regression analysis revealed that MACC1 protein over-expression in gastric cancer tended to be a protective factor with hazard ratio of 0.621 (P=0.057). Immunohistochemical analysis showed that the positive rate of c-MET protein expression was much higher in cases with positive MACC1 expression in gastric cancer (P=0.002), but P53 expression was not associated with MACC1 expression.
  
  
  CONCLUSIONS
  MACC1 over-expression implies better survival and may be an independent prognostic factor for gastric cancer in Chinese patients.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Beijing Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Ge
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Wu
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Wang
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Xing
authors.forename: Lian-Hai
authors.initials: LH
authors.lastname: Zhang
authors.forename: Yu-Bing
authors.initials: YB
authors.lastname: Zhu
authors.forename: Hong
authors.initials: H
authors.lastname: Du
authors.forename: Bin
authors.initials: B
authors.lastname: Dong
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Ji
keywords: Gastric cancer; MACC1; Prognosis