title: T-cell modulatory properties of CD5 and its role in antitumor immune responses.
abstract: The destruction of tumor cells by the immune system is under the control of positive and negative receptors that tightly regulate T-cell effector functions. The T-cell receptor (TCR) inhibitory molecule CD5 critically contributes to the regulation of antitumor immune responses. Indeed, the modulation of CD5 within the tumor microenvironment corresponds to a strategy adopted by tumor-specific cytotoxic T lymphocytes (CTLs) to optimize their cytotoxic and cytokine secretion functions. In this review, we provide insights into the immunobiology of CD5 and its role in regulating antitumor CD8 T-cell responses, and suggest the possibility of targeting CD5 to improve the efficacy of current immunotherapeutic approaches against cancer.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) U753; Team 1: Tumor Antigens and T-Cell Reactivity; Integrated Research Cancer Institute in Villejuif (IRCIV); Institut de Cancérologie Gustave Roussy (IGR); Villejuif, France.
authors.forename: Mouna
authors.initials: M
authors.lastname: Tabbekh
authors.forename: M'barka
authors.initials: M
authors.lastname: Mokrani-Hammani
authors.forename: Georges
authors.initials: G
authors.lastname: Bismuth
authors.forename: Fathia
authors.initials: F
authors.lastname: Mami-Chouaib
keywords: CD5; T cells; antitumor immune responses; tumor-infiltrating T lymphocytes