title: Short cell-penetrating peptides: a model of interactions with gene promoter sites.
abstract: Analysis of the main parameters of molecular mechanics (number of hydrogen bonds, hydrophobic and electrostatic interactions, DNA-peptide complex minimization energy) provided the data to validate the previously proposed qualitative models of peptide-DNA interactions and to evaluate their quantitative characteristics. Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: S I
authors.initials: SI
authors.lastname: Tarnovskaya
authors.forename: N S
authors.initials: NS
authors.lastname: Linkova
authors.forename: V E
authors.initials: VE
authors.lastname: Pronyaeva
authors.forename: L K
authors.initials: LK
authors.lastname: Shataeva
authors.forename: P P
authors.initials: PP
authors.lastname: Yakutseni
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D018956:CD5 Antigens / Q000235:genetics; D057846:Cell-Penetrating Peptides / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000032:analysis; D004151:Dipeptides / Q000737:chemistry* / Q000378:metabolism; D007376:Interleukin-2 / Q000235:genetics; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism; D010446:Peptide Fragments; D011401:Promoter Regions, Genetic; D055672:Static Electricity
chemical_list: D018956:CD5 Antigens; D057846:Cell-Penetrating Peptides; D004268:DNA-Binding Proteins; D004151:Dipeptides; D007376:Interleukin-2; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009842:Oligopeptides; D010446:Peptide Fragments; C486174:TRAM1 protein, human; D004247:DNA; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine