title: Anti-metastatic activities of bibenzyls from Dendrobium pulchellum.
abstract: Our investigation of the stem of Dendrobium pulchellum resulted in the isolation of four known bibenzyls, chrysotobibenzyl (1), chrysotoxine (2), crepidatin (3) and moscatilin (4). The present study reveals for the first time the ability of these four compounds to facilitate anoikis and inhibit the growth of lung cancer cells in anchorage-independent condition. The preliminary data obtained disclose the inhibitory effect on cancer cell metastasis of the isolated compounds, and provide an important new approach for cancer drug development.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Pithi
authors.initials: P
authors.lastname: Chanvorachote
authors.forename: Akkarawut
authors.initials: A
authors.lastname: Kowitdamrong
authors.forename: Thidarat
authors.initials: T
authors.lastname: Ruanghirun
authors.forename: Boonchoo
authors.initials: B
authors.lastname: Sritularak
authors.forename: Chutichot
authors.initials: C
authors.lastname: Mungmee
authors.forename: Kittisak
authors.initials: K
authors.lastname: Likhitwitayawuid
mesh_terms: D023102:Anoikis / Q000187:drug effects; D001632:Bibenzyls / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D031667:Dendrobium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D009362:Neoplasm Metastasis / Q000188:drug therapy*
chemical_list: D001632:Bibenzyls