title: Microbial sulfite respiration.
abstract: Despite its reactivity and hence toxicity to living cells, sulfite is readily converted by various microorganisms using distinct assimilatory and dissimilatory metabolic routes. In respiratory pathways, sulfite either serves as a primary electron donor or terminal electron acceptor (yielding sulfate or sulfide, respectively), and its conversion drives electron transport chains that are coupled to chemiosmotic ATP synthesis. Notably, such processes are also seen to play a general role in sulfite detoxification, which is assumed to have an evolutionary ancient origin. The diversity of sulfite conversion is reflected by the fact that the range of microbial sulfite-converting enzymes displays different cofactors such as siroheme, heme c, or molybdopterin. This chapter aims to summarize the current knowledge of microbial sulfite metabolism and focuses on sulfite catabolism. The structure and function of sulfite-converting enzymes and the emerging picture of the modular architecture of the corresponding respiratory/detoxifying electron transport chains is emphasized.
authors.affiliation: Department of Biology, Microbial Energy Conversion and Biotechnology, Technische Universität Darmstadt, Schnittspahnstrasse 10, 64287 Darmstadt, Germany. simon@bio.tu-darmstadt.de
authors.forename: Jörg
authors.initials: J
authors.lastname: Simon
authors.forename: Peter M H
authors.initials: PM
authors.lastname: Kroneck
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D001419:Bacteria / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D004579:Electron Transport; D004734:Energy Metabolism; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D010084:Oxidation-Reduction; D013431:Sulfates / Q000378:metabolism; D013440:Sulfides / Q000378:metabolism; D013447:Sulfites / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D004798:Enzymes; D013431:Sulfates; D013440:Sulfides; D013447:Sulfites; D000255:Adenosine Triphosphate