title: [The experimental search of immunological criteria for identifying stages of development of chronic fluoride intoxication].
abstract: The experiment has shown the staging of the development of immune response to the chronic fluoride intoxication. Diagnostic criteria of the initial compensation stage are: leukocytosis against the background of reduced number of lymphocytes and increased one of monocytes; high levels of ceruloplasmin in blood plasma, a progressive increase in TNFalpha and cytokine IL-10. At the decompensation stage there are: leukocytosis with increased number of neutrophils; low levels of ceruloplasmin and the cytokines IL-1beta, IL-4 and the high level of TNFalpha, IL-6, IL-10. At the stage of exhaustion there are: leukopenia against the background of lymphocytosis, a high level of Hp, the low values of the level of IgM, IgG.
authors.forename: N N
authors.initials: NN
authors.lastname: Mikhaĭlova
authors.forename: A S
authors.initials: AS
authors.lastname: Kazitskaia
authors.forename: L G
authors.initials: LG
authors.lastname: Gorokhova
authors.forename: A G
authors.initials: AG
authors.lastname: Zhukova
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D004195:Disease Models, Animal; D005458:Fluoride Poisoning / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D017611:Fluorine Compounds / Q000008:administration & dosage / Q000276:immunology / Q000633:toxicity; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D015166:Monitoring, Immunologic / Q000379:methods; D051381:Rats; D013997:Time Factors
chemical_list: D015415:Biomarkers; D016207:Cytokines; D017611:Fluorine Compounds; D007074:Immunoglobulin G; D007075:Immunoglobulin M