title: Metformin-acting through cyclic AMP as well as AMP?
abstract: Metformin, developed from an ancient herbal remedy, remains the front-line drug for treatment of type 2 diabetes. Several targets to account for its therapeutic effects have been proposed, but a recent paper suggests a novel mechanism in which it antagonizes the cyclic AMP-dependent effects of glucagon on hepatic glucose production.
authors.affiliation: Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK. d.g.hardie@dundee.ac.uk
authors.forename: D Grahame
authors.initials: DG
authors.lastname: Hardie