title: Multi-step down-regulation of the secretory pathway in mitosis: a fresh perspective on protein trafficking.
abstract: The secretory pathway delivers proteins synthesized at the rough endoplasmic reticulum (RER) to various subcellular locations via the Golgi apparatus. Currently, efforts are focused on understanding the molecular machineries driving individual processes at the RER and Golgi that package, modify and transport proteins. However, studies are routinely performed using non-dividing cells. This obscures the critical issue of how the secretory pathway is affected by cell division. Indeed, several studies have indicated that protein trafficking is down-regulated during mitosis. Moreover, the RER and Golgi apparatus exhibit gross reorganization in mitosis. Here I provide a relatively neglected perspective of how the mitotic cyclin-dependent kinase (CDK1) could regulate various stages of the secretory pathway. I highlight several aspects of the mitotic control of protein trafficking that remain unresolved and suggest that further studies on how the mitotic CDK1 influences the secretory pathway are necessary to obtain a deeper understanding of protein transport.
authors.affiliation: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. foong_may_yeong@nuhs.edu.sg
authors.forename: Foong May
authors.initials: FM
authors.lastname: Yeong
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D016203:CDC2 Protein Kinase / Q000235:genetics / Q000378:metabolism*; D016466:CHO Cells; D003412:Cricetulus; D018870:Endoplasmic Reticulum, Rough / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006056:Golgi Apparatus / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000235:genetics / Q000378:metabolism; D008938:Mitosis / Q000235:genetics*; D021381:Protein Transport; D055571:Secretory Pathway / Q000235:genetics*
chemical_list: D000199:Actins; D016203:CDC2 Protein Kinase