title: Subcutaneous administration of sodium alginate oligosaccharides prevents salt-induced hypertension in Dahl salt-sensitive rats.
abstract: OBJECTIVE
  We investigated the mechanism of antihypertensive effects of sodium alginate oligosaccharides, which are enzymatic products of high-molecular-weight natural alginate from seaweeds, in Dahl salt-sensitive (Dahl S) rats.
  
  
  METHODS
  Dahl S rats fed a high-salt (4% NaCl) diet were subcutaneously administered sodium alginate oligosaccharides (60 mg/day using a continuous osmotic mini-pump) for 14 days. Systolic blood pressure (SBP) was measured using the tail-cuff method, and we determined the influence of the alginate treatment on the metabolism of sodium by measuring sodium excretions in the feces and urine.
  
  
  RESULTS
  SBP increased in an age-dependent manner in the untreated Dahl S rats. Sodium alginate oligosaccharide treatment via the subcutaneous route almost completely abolished salt-induced hypertension in Dahl S rats fed a high-salt diet. The level of fecal or urinary sodium excretion did not significantly change during the treatment period with the alginate oligosaccharides. The reduction in SBP rapidly recovered after cessation of the treatment. Moreover, the level of urinary protein excretion was lower in the treated Dahl S rats than in the untreated rats during the experimental period.
  
  
  CONCLUSIONS
  Our results suggest that sodium alginate oligosaccharides attenuate salt-induced hypertension in Dahl S rats not through reducing salt absorption, but probably through a direct action on vascular vessels.
authors.affiliation: Department of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women's University , Tokyo , Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Moriya
authors.forename: Yui
authors.initials: Y
authors.lastname: Shida
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamane
authors.forename: Yuki
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Midori
authors.initials: M
authors.lastname: Kimura
authors.forename: Naomi
authors.initials: N
authors.lastname: Huse
authors.forename: Kaori
authors.initials: K
authors.lastname: Ebisawa
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kameda
authors.forename: Ayaka
authors.initials: A
authors.lastname: Nishi
authors.forename: DongDong
authors.initials: D
authors.lastname: Du
authors.forename: Mariko
authors.initials: M
authors.lastname: Yoshinaga
authors.forename: Itsuki
authors.initials: I
authors.lastname: Murota
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Uehara
mesh_terms: D000464:Alginates / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005243:Feces / Q000737:chemistry; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000494:pharmacology; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000494:pharmacology; D006973:Hypertension / Q000139:chemically induced*; D055104:Infusions, Subcutaneous; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009844:Oligosaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D020303:Rats, Inbred Dahl; D012964:Sodium / Q000378:metabolism; D017673:Sodium Chloride, Dietary / Q000506:poisoning*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D009844:Oligosaccharides; D017673:Sodium Chloride, Dietary; D020723:Glucuronic Acid; D012964:Sodium