title: Role of serum IL-23/IL-17 axis in the relationship between periodontitis and coronary heart disease.
abstract: To explore the role of the IL-23/IL-17 axis in the relationship between periodontitis and coronary heart disease (CHD), 97 subjects were recruited and divided into four groups: (1) CHD + periodontitis, (2) CHD, (3) periodontitus alone, and (4) healthy. The demographic characteristics and periodontal status of all subjects were recorded, and the serum levels of IL-23/IL-17 were detected by enzyme-linked immunoabsorbent assay. Results showed that the serum levels of IL-23/IL-17 in groups 1, 2, and 3 were higher compared with group 4. Group 1 manifested the highest level of serum IL-23/IL-17. A significant positive correlation between IL-23 and IL-17 levels was seen in the three patients groups; groups 1 and 3 also had significant positive correlations with probing depth and attachment loss. The results indicate that there may be an association between periodontitis and CHD, and the IL-23/IL-17 axis may play an important role in the pathologic process of both diseases.
authors.affiliation: Department of Periodontology, School of Stomatology, Shandong University, Jinan, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Qi
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.forename: Aimei
authors.initials: A
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Song
authors.forename: Shiguo
authors.initials: S
authors.lastname: Yan
authors.forename: Qinfeng
authors.initials: Q
authors.lastname: Sun
authors.forename: Pishan
authors.initials: P
authors.lastname: Yang
mesh_terms: D016301:Alveolar Bone Loss / Q000097:blood / Q000150:complications / Q000276:immunology; D000787:Angina Pectoris / Q000097:blood / Q000150:complications / Q000276:immunology; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000276:immunology; D023921:Coronary Stenosis / Q000097:blood / Q000150:complications / Q000276:immunology; D003774:Dental Plaque Index; D005260:Female; D005884:Gingival Hemorrhage / Q000097:blood / Q000150:complications / Q000276:immunology; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D053759:Interleukin-23 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000097:blood / Q000150:complications / Q000276:immunology; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000150:complications / Q000276:immunology; D010518:Periodontitis / Q000097:blood* / Q000150:complications / Q000276:immunology
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23