title: Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin.
abstract: Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin, which are biosynthetic intermediates from β-carotene to astaxanthin, were investigated. Both adonirubin and adonixanthin showed almost the same activities for inhibition of lipid peroxidation and quenching of singlet oxygen as those of astaxanthin. Furthermore, adonirubin and adonixanthin exhibited an inhibitory effect on Epstein-Barr virus early antigen activation in Raji cells and carcinogensis of mouse skin tumors initiated by 7,12-dimethylbenz[a]anthracene and promoted by 12-O-tetradecanoylphorbol-13-acetate.
authors.affiliation: Research Institute for Production Development, Sakyou-ku, Kyoto 607-0805, Japan. maoka@mbox.kyoto-inet.or.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Maoka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yasui
authors.forename: Aya
authors.initials: A
authors.lastname: Ohmori
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Suzuki
authors.forename: Ayako
authors.initials: A
authors.lastname: Osawa
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shindo
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishibashi
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D016644:Canthaxanthin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D002338:Carotenoids / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D010230:Paracoccus / Q000737:chemistry / Q000378:metabolism; D026082:Singlet Oxygen / Q000737:chemistry; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors; D014763:Viral Matrix Proteins / Q000037:antagonists & inhibitors*
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins; D026082:Singlet Oxygen; D002338:Carotenoids; D016644:Canthaxanthin; D015127:9,10-Dimethyl-1,2-benzanthracene; C586187:adonirubin; D013755:Tetradecanoylphorbol Acetate; C539602:adonixanthin