title: Chronic pulmonary dysfunction following acute inhalation of butyl acrylate.
abstract: Butyl Acrylate (BA) (2-propionic acid; CH2 = CHCOOC4H9) is a colorless liquid commonly used in impregnation agents and adhesives. Dermal contact with BA has previously been reported to cause moderate skin irritation with skin sensitizing potential in humans. Health effects of inhalation of BA have not been previously reported. Accordingly, we document the health conditions of a bystander, first responder and landfill worker exposed to butyl acrylate (BA) released to the atmosphere following a collision and roadside spill in October 1998. Retrospective data were collected via chart review and analyzed for exposure, symptoms, physical findings and radiological, laboratory and spirometry results over a ten-year period. All three patients had similar respiratory symptoms including a dramatic hacking cough and dyspnea. Findings included abnormal pulmonary function tests and breath sounds. These data underscore the potential hazards of BA inhalational exposure and the need to wear additional protective equipment.
authors.affiliation: Section of Cardiology, WVU Heart Institute, WV, USA.
authors.forename: Ravindra
authors.initials: R
authors.lastname: Bhardwaj
authors.forename: Alan
authors.initials: A
authors.lastname: Ducatman
authors.forename: Mitchell S
authors.initials: MS
authors.lastname: Finkel
authors.forename: Edward
authors.initials: E
authors.lastname: Petsonk
authors.forename: Janet
authors.initials: J
authors.lastname: Hunt
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Beto
mesh_terms: D000179:Acrylates / Q000633:toxicity*; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D008171:Lung Diseases / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000179:Acrylates; C032490:n-butyl acrylate