title: Lack of association between carotid intima-media thickness and apolipoprotein (a) isoforms in a sample of Spanish general population.
abstract: OBJECTIVE
  The purpose of this study was to examine the relationship between apolipoprotein (a) isoforms and early atherosclerosis, assessed by carotid artery intima-media thickness in a sample of adults of the general population of Burgos, a city in the north of Spain.
  
  
  METHODS
  Lipids, lipoprotein (a), number of carotid atherosclerotic plaques, if any, and the intima-media thickness in the far wall of both common carotid arteries by B-mode ultrasound were determined in a group of 171 adults from the general population of Burgos, Spain. Apolipoprotein (a) isoforms were determined in a random subset of 119 subjects.
  
  
  RESULTS
  Increasing age, male sex, and past personal cardiovascular history were significantly associated with increased left, right, or average intima-media thickness of both carotid arteries in multivariate analysis. No statistically significant association was found between apolipoprotein (a) isoforms and mean carotid intima-media thickness by bivariate or multivariate regression analysis.
  
  
  CONCLUSIONS
  In this sample of the general Spanish population, no association was found between apolipoprotein (a) isoforms and carotid artery intima-media thickness.
authors.affiliation: Hospital Universitario Miguel Servet, Zaragoza, Spain. mpcalmarza@salud.aragon.es
authors.forename: Pilar
authors.initials: P
authors.lastname: Calmarza
authors.forename: Jose M
authors.initials: JM
authors.lastname: Trejo
authors.forename: Carlos
authors.initials: C
authors.lastname: Lapresta
authors.forename: Pilar
authors.initials: P
authors.lastname: Lopez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053241:Apoprotein(a) / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020033:Protein Isoforms / Q000097:blood; D011897:Random Allocation; D013030:Spain; D044465:White People
chemical_list: D020033:Protein Isoforms; D053241:Apoprotein(a)