title: Functional melanocortin 1 receptor Mc1r is not necessary for an inflammatory response to UV radiation in adult mouse skin.
abstract: The G-protein-coupled receptor, Mc1r, plays a major role in pigment production and has been reported to be important in the inflammatory response. We have investigated the effect of deficiency in Mc1r on UV-induced inflammation. Mice on the same genetic background were used - C57BL/6-c (albino), C57BL/6 (black), C57BL/6-Mc1r(e/e) deficient (yellow). FACS analysis of disaggregated skin showed a similar dose-dependent increase in Ly6G(+) and CD11b(+) cells in response to UV radiation in all groups. No differences in UV-induced edema or in DNA damage were detected between groups. The contact hypersensitivity response, neonatal immune tolerance and UV immunosuppression were all similar in C57BL/6 and C57BL/6-Mc1r(e/e) mice. We conclude that the absence of Mc1r does not impair the inflammatory response to UV radiation or the generation of immunosuppression.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wolnicka-Glubisz
authors.forename: Edward
authors.initials: E
authors.lastname: De Fabo
authors.forename: Frances
authors.initials: F
authors.lastname: Noonan
mesh_terms: D000818:Animals; D000950:Antigens, Ly / Q000378:metabolism; D039481:CD11b Antigen / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008544:Melanocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D023421:Models, Animal; D044102:Receptor, Melanocortin, Type 1 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D012867:Skin / Q000473:pathology / Q000503:physiopathology* / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D015854:Up-Regulation / Q000528:radiation effects; D000521:alpha-MSH / Q000378:metabolism
chemical_list: D000950:Antigens, Ly; D039481:CD11b Antigen; C480309:Ly6G antigen, mouse; D044102:Receptor, Melanocortin, Type 1; D000521:alpha-MSH