title: Pure red cell aplasia caused by Parvo B19 virus in a kidney transplant recipient.
abstract: Parvo B19 is a single stranded DNA virus, which typically has affinity for erythroid progenitor cells in the bone marrow and produces a severe form of anemia known as pure red cell aplasia. This condition is particularly worse in immunocompromised individuals. We herein report a young Nepali male who developed severe and persistent anaemia after kidney transplantation while being on immunosuppressive therapy. His bone marrow examination revealed morphological changes of pure red cell aplasia, caused by parvovirus B19. The IgM antibody against the virus was positive and the virus was detected by polymerase chain reaction in the blood. He was managed with intravenous immunoglobulin. He responded well to the treatment and has normal hemoglobin levels three months post treatment. To the best of our knowledge, this is the first such case report from Nepal.
authors.affiliation: Department of Nephrology, National Academy of Medical Sciences, Bir Hospital, Kathmandu.
authors.forename: A
authors.initials: A
authors.lastname: Baral
authors.forename: B
authors.initials: B
authors.lastname: Poudel
authors.forename: R K
authors.initials: RK
authors.lastname: Agrawal
authors.forename: R
authors.initials: R
authors.lastname: Hada
authors.forename: S
authors.initials: S
authors.lastname: Gurung
mesh_terms: D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human; D012010:Red-Cell Aplasia, Pure / Q000276:immunology / Q000473:pathology / Q000821:virology*