title: Serum total adiponectin level and the risk of cardiovascular disease in general population: a meta-analysis of 17 prospective studies.
abstract: OBJECTIVE
  Many studies have assessed the association between serum adiponectin and the risk of cardiovascular disease (CVD), yet whether adiponectin is an independent risk factor for CVD remains controversial. We performed a meta-analysis of 17 prospective epidemiologic studies to evaluate this relationship in the general population.
  
  
  METHODS
  PubMed and Embase databases were searched through June 2012 to identify studies meeting a priori inclusion criteria, in addition to conducting a secondary reference review. Two principle investigators respectively extracted the information with either fixed-effect model or random-effect model to calculate the relationship between adiponectin and the risk of CVD.
  
  
  RESULTS
  We summarized 17 prospective studies with a total of 23,717 participants. Overall, higher serum adiponectin was related to an increased risk of ischemic stroke: pooled risk ratio (RR) of 1.34 [95% confidence intervals (CI): 1.06-1.69] with no heterogeneity (Q = 1.23; P = 0.541). Serum adiponectin was not related to coronary heart disease (CHD) or CVD: pooled RR of 0.96 (95% CI: 0.85-1.08) and 1.00 (95% CI: 0.89-1.13), respectively.
  
  
  CONCLUSIONS
  Increased serum adiponectin was related to an elevated risk of ischemic stroke, but there was no clear evidence indicating a positive relationship between adiponectin and the risk of CHD or CVD.
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Hao
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Guo
authors.forename: Jin-Gang
authors.initials: JG
authors.lastname: Yang
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Tian
authors.forename: Man-Yun
authors.initials: MY
authors.lastname: Liu
authors.forename: Ya-Guang
authors.initials: YG
authors.lastname: Peng
authors.forename: Zeng-Wu
authors.initials: ZW
authors.lastname: Wang
mesh_terms: D052242:Adiponectin / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin