title: Novasure as a mechanical endometrial preparation agent in large uteri.
abstract: OBJECTIVE
  We evaluated Novasure ablation as a mechanical endometrial preparation agent before Roller Ball endometrial ablation in lieu of GnRH agonists in large uteri.
  
  
  METHODS
  A retrospective chart review of 20 consecutive patients undergoing Novasure ablation for mechanical endometrial preparation before Roller Ball ablation (RBNovasure group) was conducted and the results compared to that of 23 consecutive patients who received GnRH agonist (Leuprolide acetate) as a medical endometrial preparation before Roller Ball ablation (RB-Lupron group). The postoperative follow-up time frame was divided into immediate (3 mo), intermediate (3 to 12 mo) and long-term (12 to 32 mo). Rates of amenorrhea, heavy bleeding, cramping, and failure (repeat ablation or hysterectomy for heavy bleeding or persistent pain) were compared between the 2 groups.
  
  
  RESULTS
  The mean rates of amenorrhea for the patients not lost to follow-up at 3 mo, 3 to 12 mo, and 12 to 32 mo visits were 45.5%, 58.8%, and 44.4% for the RB-Lupron group, and 80%, 86.7%, and 100% for the RB-Novasure group (P = .02, P = .08, and P = .02). Failure rates were 4.8%, 6.2%, and 55.6% for the RB-Lupron group; and 0 (0/20), 12.5% (2/16) and 0 (0/8) for the RB-Novasure group (P = .51, P = .50, and P = .02). The RB-Novasure group had a significantly lower rate of heavy bleeding and cramping. 86.4%, 58.8%, and 33.3% patients reported satisfaction with their treatment in the RB-Lupron group and 100%, 87.5%, and 75% in RB-Novasure group (P = .13, P = .07, and P = .11).
  
  
  CONCLUSIONS
  Novasure ablation, for mechanical endometrial preparation before Roller Ball ablation, appears to be a superior alternative to medical preparation with GnRH agonists in patients with large uteri.
authors.affiliation: Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, PA, USA. sushmapotti@gmail.com
authors.forename: Sushma
authors.initials: S
authors.lastname: Potti
authors.forename: Shitanshu
authors.initials: S
authors.lastname: Uppal
authors.forename: Ashwin J
authors.initials: AJ
authors.lastname: Chatwani
authors.forename: Enrique
authors.initials: E
authors.lastname: Hernandez
authors.forename: Vani
authors.initials: V
authors.lastname: Dandolu
mesh_terms: D000328:Adult; D017115:Catheter Ablation / Q000295:instrumentation*; D004717:Endometrium / Q000601:surgery*; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology; D005500:Follow-Up Studies; D006801:Humans; D016729:Leuprolide / Q000494:pharmacology*; D017060:Patient Satisfaction; D011300:Preoperative Care / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014592:Uterine Hemorrhage / Q000601:surgery*
chemical_list: D005300:Fertility Agents, Female; D016729:Leuprolide