title: Dipeptidyl peptidase IV: serum activity and expression on lymphocytes in different hematological malignancies.
abstract: The aim of this research was to determine the serum dipeptidyl peptidase IV (DPPIV) activity as well as the percentages of CD26 + lymphocytes and CD26 + overall white blood cells in patients with hematological malignancies: non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), leukemia, plasmacytoma and multiple myeloma, and in healthy individuals. Data from our study showed significantly decreased serum DPPIV activity and a significant decrease in the percentage of: CD26 + lymphocytes, CD26 + overall white blood cells and lymphocytes in patients with NHL in comparison to healthy controls. Patients with leukemia had a statistically significant lower activity of DPPIV in serum and significant decrease in the percentage of CD26 + lymphocytes in relation to healthy controls. Furthermore, significantly decreased DPPIV serum activity associated with a significantly reduced percentage of CD26 + overall white blood cells and percentage of lymphocytes was found in patients with multiple myeloma when compared to the healthy control group. The obtained results indicate that immune disturbances that can occur in hematological malignancies might be related to the decreased expression and activity of CD26/DPPIV that we observed.
authors.affiliation: Institute of Oncology and Radiology of Serbia , Belgrade , Serbia.
authors.forename: Ivana Z
authors.initials: IZ
authors.lastname: Matić
authors.forename: Milica
authors.initials: M
authors.lastname: Đorđević
authors.forename: Marija
authors.initials: M
authors.lastname: Đorđić
authors.forename: Nađa
authors.initials: N
authors.lastname: Grozdanić
authors.forename: Ana
authors.initials: A
authors.lastname: Damjanović
authors.forename: Branka
authors.initials: B
authors.lastname: Kolundžija
authors.forename: Ana
authors.initials: A
authors.lastname: Vidović
authors.forename: Jelena
authors.initials: J
authors.lastname: Bila
authors.forename: Slobodan
authors.initials: S
authors.lastname: Ristić
authors.forename: Biljana
authors.initials: B
authors.lastname: Mihaljević
authors.forename: Dragica
authors.initials: D
authors.lastname: Tomin
authors.forename: Nenad
authors.initials: N
authors.lastname: Milanović
authors.forename: Dušan
authors.initials: D
authors.lastname: Ristić
authors.forename: Mila
authors.initials: M
authors.lastname: Purić
authors.forename: Dušica
authors.initials: D
authors.lastname: Gavrilović
authors.forename: Oscar J
authors.initials: OJ
authors.lastname: Cordero
authors.forename: Zorica D
authors.initials: ZD
authors.lastname: Juranić
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018819:Dipeptidyl Peptidase 4 / Q000097:blood* / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D019337:Hematologic Neoplasms / Q000097:blood* / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D018819:Dipeptidyl Peptidase 4