title: Curcuminoids modulate pro-oxidant-antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals.
abstract: Curcuminoids have potentially important functional qualities including anti-inflammatory and antioxidant properties. In this randomized double-blind placebo-controlled cross-over trial, the effects of a curcuminoid supplement on serum pro-oxidant-antioxidant balance (PAB) and antibody titres to Hsp27 (anti-Hsp27) and oxLDL (anti-oxLDL) were investigated. Thirty obese individuals were randomized to receive either curcuminoids (1 g/day) or placebo for a period of 30 days. After a wash-out period of 2 weeks, subjects were crossed over to the alternate regimen for another 30 days. Serum PAB along with anti-Hsp27 and anti-oxLDL titres was measured at the beginning and at the end of each study period. There was no significant carry-over effect for any of the assessed parameters. Curcuminoid supplementation was associated with a significant decrease in PAB (p = 0.044). However, no significant change was observed in serum concentrations of anti-Hsp27 or anti-oxLDL (p > 0.05). These findings suggest that oral curcuminoids supplementation (1g/day) is effective in reducing oxidative stress burden, though this needs to be validated in larger study populations.
authors.affiliation: Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Biochemistry and Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.forename: Akram
authors.initials: A
authors.lastname: Mohammadi
authors.forename: Ali
authors.initials: A
authors.lastname: Atabati
authors.forename: Shamim
authors.initials: S
authors.lastname: Rahiman
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Iranshahi
authors.forename: Saeed
authors.initials: S
authors.lastname: Akhlaghi
authors.forename: Gordon Aa
authors.initials: GA
authors.lastname: Ferns
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D000975:Antioxidants / Q000378:metabolism*; D018592:Cross-Over Studies; D003474:Curcumin / Q000494:pharmacology*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000276:immunology*; D006360:Heat-Shock Proteins; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D009765:Obesity / Q000276:immunology*; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000906:Antibodies; D000975:Antioxidants; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D008077:Lipoproteins, LDL; D018832:Molecular Chaperones; D016877:Oxidants; D017382:Reactive Oxygen Species; C099252:oxidized low density lipoprotein; D003474:Curcumin
keywords: curcumin; heat shock protein 27; oxidative stress; oxidized low-density lipoprotein