title: Arachidonic and docosahexaenoic acid in the blood of a mother and umbilical vein in diabetic pregnant women.
abstract: OBJECTIVE
  The aim of the study was to determine the total concentration of fatty acids (FAs) in the maternal vein serum and in the umbilical vein serum in pregnant women suffering from Type 1 diabetes compared to healthy women. Additional goal was to determine the percentages of arachidonic (AA) and docosahexaenoic acid (DHA) in comparison to the total concentration of FAs.
  
  
  METHODS
  The study included 63 pregnant women, 32 suffering from Type 1 diabetes and 31 healthy pregnant women. Extraction of total lipids was performed using gas chromatography.
  
  
  RESULTS
  There was statistically significant difference in the total FAs concentration in the maternal vein serum and the umbilical vein serum between the two groups. There was a statistically significant higher concentration of total FAs in the maternal and umbilical vein serum of the diabetic group. Higher AA and DHA concentrations were found in the maternal vein serum compared to an umbilical vein serum of the diabetic group.
  
  
  CONCLUSIONS
  No difference was found in AA and DHA percentages in the maternal or in the umbilical vein serum of diabetic pregnant women. Despite of T1DM, a good metabolic control leads to insignificant changes in the AA and DHA levels in diabetic pregnancy.
authors.affiliation: University Clinic for Women's Diseases and Delivery, University Clinical Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia. edinaberberovic@yahoo.com
authors.forename: Edina
authors.initials: E
authors.lastname: Berberovic
authors.forename: Marina
authors.initials: M
authors.lastname: Ivanisevic
authors.forename: Josip
authors.initials: J
authors.lastname: Juras
authors.forename: Marina
authors.initials: M
authors.lastname: Horvaticek
authors.forename: Ivancica
authors.initials: I
authors.lastname: Delas
authors.forename: Josip
authors.initials: J
authors.lastname: Djelmis
mesh_terms: D000328:Adult; D016718:Arachidonic Acid / Q000097:blood*; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D004281:Docosahexaenoic Acids / Q000097:blood*; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D009035:Mothers; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D014471:Umbilical Veins / Q000737:chemistry*
chemical_list: D005227:Fatty Acids; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid