title: Severe disseminated phaeohyphomycosis in an immunocompetent patient caused by Veronaea botryosa.
abstract: We present a severe case of disseminated phaeohyphomycosis due to Veronaea botryosa. A 32-year-old female, native from Cuautla, Morelos, Mexico, presented a chronic dermatosis which started 10 years earlier with multiple exophytic, multilobulated, soft, and pedunculated or sessile neoformations of diverse sizes from 2 to 10 cm in diameter, which became verrucose and increased in size. The patient was immunocompetent, and no hereditary or familiar precedents of importance were known. No treatment was given, and the dermatosis remained relatively stable until the patient became pregnant in 2001 and 2003. The infection then exacerbated and worsened, leading to dissemination to the extremities, trunk, and face. The initial diagnosis was chromoblastomycosis which was treated with terbinafine and itraconazole but without visible improvement. Histopathology revealed pigmented, irregular, unbranched, and septate hyphae. Veronaea botryosa was isolated (CBS 127264 = JX566723), and its identity was confirmed by sequencing the internal transcribed spacer (ITS) rDNA. Therapy with posaconazole (800 mg/day) was started showing a gradual improvement of lesions with a reduction in size and flattening of the eruptions.
authors.affiliation: Mycology Department, Service of Dermatology, Hospital General de Mexico, Mexico City, Mexico.
authors.forename: Alexandro
authors.initials: A
authors.lastname: Bonifaz
authors.forename: Mehrnaz Mohammad
authors.initials: MM
authors.lastname: Davoudi
authors.forename: G S
authors.initials: GS
authors.lastname: de Hoog
authors.forename: Carmen
authors.initials: C
authors.lastname: Padilla-Desgarennes
authors.forename: Denisse
authors.initials: D
authors.lastname: Vázquez-González
authors.forename: Gisela
authors.initials: G
authors.lastname: Navarrete
authors.forename: Jacques F
authors.initials: JF
authors.lastname: Meis
authors.forename: Hamid
authors.initials: H
authors.lastname: Badali
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001203:Ascomycota / Q000302:isolation & purification*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008800:Mexico; D060446:Phaeohyphomycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D011247:Pregnancy; D017422:Sequence Analysis, DNA; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D014230:Triazoles; C101425:posaconazole