title: Large-scale studies to identify biomarkers for heart disease: a role for proteomics?
abstract: BACKGROUND
  In clinical practice, timely detection of disease and accurate diagnosis are highly important for the effective treatment of various patient populations. Biomarkers offer a new and innovative means of assessing the disease state during early, mid and late stages of progression.
  
  
  OBJECTIVE
  Advancements in various proteomic platforms used to study the disease proteome and their applications to the field of clinical medicine are reviewed.
  
  
  METHODS
  A literature review was done to study proteomic technology and its contribution to the discovery of cardiac biomarkers.
  
  
  CONCLUSIONS
  Proteomic profiling experiments can allow for the establishment of cardiac biomarkers, which can often offer information regarding the severity of the disease state. As high-throughput evaluation of various cardiac disease proteomes continues to improve in precision, the prospect of offering medical treatment that is tailored to the individual could follow.
authors.affiliation: University of Toronto, Department of Physiology, 112 College St, Rm 307, ON, Canada M5G 1L6 +1 416 978 5609 ; +1 416 978 8528 ; anthony.gramolini@utoronto.ca.
authors.forename: Shaan
authors.initials: S
authors.lastname: Chugh
authors.forename: Peter
authors.initials: P
authors.lastname: Liu
authors.forename: Andrew
authors.initials: A
authors.lastname: Emili
authors.forename: Anthony
authors.initials: A
authors.lastname: Gramolini