title: Autonomic nervous system balance in children and adolescents with craniopharyngioma and hypothalamic obesity.
abstract: OBJECTIVE
  Dysregulation of the autonomic nervous system is thought to be involved in craniopharyngioma-related hypothalamic obesity (CRHO). Increased parasympathetic activity and decreased sympathetic activity have been suggested. We aimed to study autonomic activity using heart rate variability (HRV) and biochemical measures in youth with CRHO compared with controls and to explore relationships between obesity and autonomic indices.
  
  
  METHODS
  A cross-sectional study of 16 youth with CRHO and 16 controls matched for sex, age, and BMI.
  
  
  METHODS
  Anthropometrics, fasting blood-work, resting energy expenditure (REE), 24-h HRV, and 24-h urine catecholamines were assessed. Quality of life, sleepiness, and autonomic symptoms were evaluated. Power spectral analysis of the HRV was performed.
  
  
  RESULTS
  HRV power spectral analysis parameters of both parasympathetic activity (mean high frequency (HF (ms(2))) 611±504 vs 459±336, P=0.325) and sympathetic activity (median low frequency/HF 1.62 (1.37, 2.41) vs 1.89 (1.44, 2.99), P=0.650) did not differ between the groups. Parasympathetic activity negatively correlated with central adiposity in both groups (r=-0.53, P=0.034 and r=-0.54, P=0.029) and sympathetic activity positively correlated with central adiposity in CRHO (r=0.51, P=0.043). Youth with CRHO had significantly lower REE; lower health and activity scores in the quality of life questionnaires, and higher sleepiness scores.
  
  
  CONCLUSIONS
  Autonomic activity was similar in CRHO and control subjects. The degree of central adiposity correlated negatively with parasympathetic activity and positively with sympathetic activity in children with CRHO. These results provide a new perspective regarding autonomic balance in this unique patient population.
authors.affiliation: Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Michal
authors.initials: M
authors.lastname: Cohen
authors.forename: Catriona
authors.initials: C
authors.lastname: Syme
authors.forename: Brian W
authors.initials: BW
authors.lastname: McCrindle
authors.forename: Jill
authors.initials: J
authors.lastname: Hamilton
mesh_terms: D000293:Adolescent; D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D002648:Child; D003397:Craniopharyngioma / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007027:Hypothalamic Diseases / Q000503:physiopathology*; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D055815:Young Adult