title: Cytokine profile of a self-healing Fonsecaea pedrosoi infection in murine model.
abstract: Chromoblastomycosis is a chronic infectious disease of the skin and subcutaneous tissue. However, the host-defence response to this fungal infection has not been investigated thoroughly. This study was carried out to analyse the sequential events and the change of local cytokine release in a murine model infected with Fonsecaea pedrosoi in footpad. The anti-inflammatory Th2 cytokine IL-10 demonstrated an upward trend up to 7 days post infection followed by a steady decline. The titers of TNF-α (a pro-inflammatory Th1 cytokine) increased up to 7 days post infection followed by a relatively steady-state until full recovery. The anti-inflammatory cytokine IL-4 showed a similar pattern as TNF-α. The pro-inflammatory cytokine IFN-γ did not increased until 7 days post infection, while demonstrated an upward trend up to 30 days when the mice reached a full recovery from infection.
authors.affiliation: Department of Dermatology, Provincial Hospital Affiliated to Shandong University, 324 Jing Wu Road, Jinan, 250021, People's Republic of China, drhongwang2013@gmail.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Weidong
authors.initials: W
authors.lastname: Mu
authors.forename: Qing
authors.initials: Q
authors.lastname: Ja
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.forename: Ruie
authors.initials: R
authors.lastname: Chen
authors.forename: Guixia
authors.initials: G
authors.lastname: Lv
authors.forename: Yongnian
authors.initials: Y
authors.lastname: Shen
authors.forename: Weida
authors.initials: W
authors.lastname: Liu
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism*; D004195:Disease Models, Animal; D005528:Foot / Q000382:microbiology; D020508:Fungi, Unclassified / Q000502:physiology*; D005786:Gene Expression Regulation; D007963:Leukocytes, Mononuclear / Q000166:cytology; D051379:Mice; D009181:Mycoses / Q000276:immunology / Q000378:metabolism*
chemical_list: D016207:Cytokines