title: Dabigatran overdose secondary to acute kidney injury and amiodarone use.
abstract: Oral direct thrombin inhibitors have improved treatment of non-valvular atrial fibrillation. Safety concerns have been raised since there is no antidote for treatment of secondary haemorrhages and the absence of widely validated test to monitor drug levels. We present a case of dabigatran overdose in an 82-year-old female who was treated with a seemingly appropriate dose.
authors.affiliation: Department of Medicine, Lenox Hill Hospital, 100 E 77 St, 10075, New York, NY, USA. cfountzilas@nshs.edu
authors.forename: Christos
authors.initials: C
authors.lastname: Fountzilas
authors.forename: Jerry
authors.initials: J
authors.lastname: George
authors.forename: Randy
authors.initials: R
authors.lastname: Levine
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications*; D000369:Aged, 80 and over; D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D000991:Antithrombins / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics*; D001281:Atrial Fibrillation / Q000188:drug therapy; D001562:Benzimidazoles / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics*; D003404:Creatinine / Q000032:analysis; D000069604:Dabigatran; D062787:Drug Overdose; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D013918:Thrombin Time; D015091:beta-Alanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D000889:Anti-Arrhythmia Agents; D000991:Antithrombins; D001562:Benzimidazoles; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D015091:beta-Alanine; D005340:Fibrinogen; D003404:Creatinine; D000069604:Dabigatran; D000638:Amiodarone