title: Synthesis of indene frameworks via rhodium-catalyzed cascade cyclization of aromatic ketone and unsaturated carbonyl compounds.
abstract: A novel rhodium(III)-catalyzed direct functionalization of the ortho-C-H bond of aromatic ketone derivatives and an intramolecular cyclization sequence produced indene derivatives in moderate to good yields. This cascade cyclization involves a conjugate addition of α,β-unsaturated ketone and subsequent aldol condensation. The reaction occurred efficiently in the presence of water and under an atmosphere of air.
authors.affiliation: Department of Chemistry, McGill University, Montreal, QC H3A 2K6, Canada.
authors.forename: Xian-Ying
authors.initials: XY
authors.lastname: Shi
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Li
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000475:Alkenes; D007192:Indenes; D007659:Ketones; D014867:Water; D012238:Rhodium