title: Copper-catalyzed formal C-N bond cleavage of aromatic methylamines: assembly of pyridine derivatives.
abstract: An efficient copper-catalyzed C-N bond cleavage of aromatic methylamines was developed to construct pyridine derivatives. With neat conditions and facile operation, the fragment-assembling strategy affords a broad range of 2,4,6-trisubstituted pyridines in up to 95% yield from simple and readily available starting materials. Interestingly, when pyridin-2-yl methylamine was employed as the substrate, α-alkylation reaction of ketones readily occurred to give β-(pyridin-2-yl) ketones instead of the 2,4,6-trisubstituted pyridines.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China.
authors.forename: Huawen
authors.initials: H
authors.lastname: Huang
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Ji
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.forename: Liangbin
authors.initials: L
authors.lastname: Huang
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000478:Alkylation; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008744:Methylamines / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*
chemical_list: D007659:Ketones; D008744:Methylamines; D011725:Pyridines; D003300:Copper