title: Expanding the synthesis of new trans-sulfonamide platinum complexes: cytotoxicity, SAR, fluorescent cell assays and stability studies.
abstract: In this manuscript, we describe the synthesis of new trans-N-sulfonamide platinum complexes and their antiproliferative activity (GI50, μM) in human solid tumors cells. The structure activity relationships (SAR), with different new synthesized complexes by variation in ligand, halogen and also in the stereochemistry of the ligand, has been studied. Solubility and stability studies have also been carried out as well as fluorescent cell assays in order to clarify the final target in the tumor cells.
authors.affiliation: Departamento de Química Inorgánica (Módulo 7), Facultad de Ciencias, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Del Solar
authors.forename: Adolfo
authors.initials: A
authors.lastname: Quiñones-Lombraña
authors.forename: Silvia
authors.initials: S
authors.lastname: Cabrera
authors.forename: José M
authors.initials: JM
authors.lastname: Padrón
authors.forename: Carla
authors.initials: C
authors.lastname: Ríos-Luci
authors.forename: Amparo
authors.initials: A
authors.lastname: Alvarez-Valdés
authors.forename: Carmen
authors.initials: C
authors.lastname: Navarro-Ranninger
authors.forename: José
authors.initials: J
authors.lastname: Alemán
mesh_terms: D001681:Biological Assay; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004355:Drug Stability; D005453:Fluorescence; D006801:Humans; D010984:Platinum / Q000737:chemistry*; D011810:Quinoxalines / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013424:Sulfanilamides / Q000737:chemistry / Q000494:pharmacology; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D056831:Coordination Complexes; D011810:Quinoxalines; D013424:Sulfanilamides; D013449:Sulfonamides; D010984:Platinum; C048021:5-chloroquinoxaline-2-sulfanilamide
keywords: Fluorescent assays; SAR; Sulfonamides; Trans-platinum complexes