title: Cardiac surgery for ergotamine-induced multivalvular heart disease.
abstract: Ergotamine is used to abort or prevent vascular headache. Valvular heart disease as an adverse effect of long-term ergotamine therapy has been rarely reported in the English literature, with only a few cases published. It is hypothesized that ergot-derived agents stimulate serotonergic receptors (5-HT2B), causing proliferation of myofibroblasts, with subsequent thickening of valve leaflets and chords. This case presentation aims at increasing clinicians' awareness of this potential complication.
authors.affiliation: Department of Cardiac Surgery, Athens Medical Center, Athens, Greece. lazopoulosg@ath.forthnet.gr
authors.forename: George
authors.initials: G
authors.lastname: Lazopoulos
authors.forename: George
authors.initials: G
authors.lastname: Papaioannou
authors.forename: Michael
authors.initials: M
authors.lastname: Kantartzis
mesh_terms: D001022:Aortic Valve Insufficiency / Q000139:chemically induced / Q000601:surgery; D002110:Caffeine / Q000009:adverse effects*; D058385:Cardiac Valve Annuloplasty; D049109:Cell Proliferation / Q000187:drug effects; D004338:Drug Combinations; D018618:Echocardiography, Doppler, Color; D004878:Ergotamine / Q000009:adverse effects*; D005260:Female; D006349:Heart Valve Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation; D006351:Heart Valves / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000139:chemically induced / Q000601:surgery; D058628:Myofibroblasts / Q000187:drug effects / Q000473:pathology; D058826:Serotonin 5-HT2 Receptor Agonists / Q000009:adverse effects*; D016896:Treatment Outcome; D014262:Tricuspid Valve Insufficiency / Q000139:chemically induced / Q000601:surgery
chemical_list: D004338:Drug Combinations; D058826:Serotonin 5-HT2 Receptor Agonists; C037330:caffeine, ergotamine drug combination; D002110:Caffeine; D004878:Ergotamine