title: Default mode network functional connectivity altered in failed back surgery syndrome.
abstract: The purpose of this study was to identify alterations in the default mode network of failed back surgery syndrome patients as compared to healthy subjects. Resting state functional magnetic resonance imaging was conducted at 3 Tesla and data were analyzed with an independent component analysis. Results indicate an overall reduced functional connectivity of the default mode network and recruitment of additional pain modulation brain regions, including dorsolateral prefrontal cortex, insula, and additional sensory motor integration brain regions, including precentral and postcentral gyri, for failed back surgery syndrome patients.
  
  
  CONCLUSIONS
  This article presents alterations in the default mode network of chronic low back pain patients with failed back surgery syndrome as compared to healthy participants.
authors.affiliation: Magnetic Resonance Technology, Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Canada. jennifer.kornelsen@nrc-cnrc.gc.ca
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kornelsen
authors.forename: Uta
authors.initials: U
authors.lastname: Sboto-Frankenstein
authors.forename: Theresa
authors.initials: T
authors.lastname: McIver
authors.forename: Patricia
authors.initials: P
authors.lastname: Gervai
authors.forename: Paul
authors.initials: P
authors.lastname: Wacnik
authors.forename: Neil
authors.initials: N
authors.lastname: Berrington
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Tomanek
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D055111:Failed Back Surgery Syndrome / Q000473:pathology* / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009434:Neural Pathways / Q000098:blood supply / Q000473:pathology; D010100:Oxygen / Q000097:blood; D011581:Psychological Tests
chemical_list: D010100:Oxygen