title: Synthesis and structure-activity relationships study of cytotoxic bufalin 3-nitrogen-containing-ester derivatives.
abstract: A series of bufalin 3-nitrogen-containing-ester derivatives (2-6) were designed, synthesized, and evaluated for their proliferation inhibition activities against human cervical epithelial adenocarcinoma (HeLa) and non-small-cell lung cancer (A549) cell lines. The structure-activity relationships (SARs) of this new series were described in this paper. Cytotoxicity data revealed that C3 moiety had important influence on cytotoxic activity. On two cell lines, the bufalin-3-piperidinyl-4-carboxylate compound 2 (IC50 values on HeLa and A549 cell lines were 0.76 nM and 0.34 nM, respectively) displayed a significant cytotoxic potency compared to the parent compound bufalin.
authors.affiliation: Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
authors.forename: Biao
authors.initials: B
authors.lastname: Ma
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Xiao
authors.forename: Yi-Jia
authors.initials: YJ
authors.lastname: Chen
authors.forename: Min
authors.initials: M
authors.lastname: Lei
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Meng
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Hu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002018:Bufanolides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D004952:Esters; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009584:Nitrogen / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002018:Bufanolides; D004952:Esters; D009584:Nitrogen; C022777:bufalin