title: Serum leptin levels in patients with coronary artery disease.
abstract: BACKGROUND
  Cardiovascular diseases (CVD) are the leading cause of morbidity, mortality and disability worldwide. Leptin, a 16kDa product of ob gene, is an endocrine hormone produced by white adipose tissue. It is primarily involved in the regulation of food intake and energy expenditure. Hyperleptinemia is one of the novel risk factors contributing in many ways to CVD.
  
  
  OBJECTIVE
  The objective of the study was to find the level of leptin in patients with coronary artery disease (CAD) and compare it with healthy people in our population.
  
  
  METHODS
  Our study was an analytical and cross-sectional study. Our study included 60 patients with a history of CAD and 60 healthy controls (aged 40-60 years, both sexes). Leptin levels were measured by ELISA.
  
  
  RESULTS
  Mean serum leptin level in patients was 11.48 +/- 11.25 etag/ml, while control group had a mean leptin level of 8.22 +/- 8.01 etag/ml (p = 0.071).
  
  
  CONCLUSIONS
  Leptin levels were higher in patients but the difference was non-significant. More studies are needed with larger sample size in our population.
authors.affiliation: Department of Biochemistry, University of Health Sciences, Lahore, Pakistan. shamaakram@yahoo.com
authors.forename: Shama
authors.initials: S
authors.lastname: Akram
authors.forename: Zamir
authors.initials: Z
authors.lastname: Ahmed
authors.forename: Iram
authors.initials: I
authors.lastname: Fayyaz
authors.forename: Sadia
authors.initials: S
authors.lastname: Mehmood
authors.forename: Mansoor
authors.initials: M
authors.lastname: Ghani
authors.forename: Anbreen Mazhar
authors.initials: AM
authors.lastname: Choudhary
authors.forename: Imran
authors.initials: I
authors.lastname: Shah
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D020738:Leptin