title: Effect of transplantation of mesenchymal stem cells on the density of pial microvascular network in rats of different age.
abstract: Using a TV device for studying microcirculation (×40), we studied the density of the whole microvascular network and arteriolar its compartment in the pia mater of the sensorimotor cortex in rats of different age (2-3, 12, and 24 months) after intracerebral transplantation of mesenchymal stem cells or nutrient medium (control). The density of the microvascular network in the pia mater remained practically unchanged until 1 year, but then decreased by 1.8 times with adding (up to 2 years). MSC transplantation 1.5-1.8-fold increased the density of the pial microvessels in animals of all age groups in comparison with intact and control rats; the density of the arteriolar compartment increased by 2.1-2.4 times. Intracerebral injection of MSC to 1-year-old animals prevented pathological decrease in the density of microvascular network during the next year of life.
authors.affiliation: Laboratory of Physiology of Circulation, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. sib@kolt.infran.ru
authors.forename: I B
authors.initials: IB
authors.lastname: Sokolova
authors.forename: I V
authors.initials: IV
authors.lastname: Sergeev
authors.forename: S V
authors.initials: SV
authors.lastname: Anisimov
authors.forename: M V
authors.initials: MV
authors.lastname: Puzanov
authors.forename: D P
authors.initials: DP
authors.lastname: Dvoretsky
mesh_terms: D000818:Animals; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology; D055806:Microvessels / Q000166:cytology*; D018919:Neovascularization, Physiologic; D010841:Pia Mater / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar