title: Rheumatoid arthritis diagnosis with antimutated citrullinated vimentin ELISA by Orgentec Diagnostika.
abstract: BACKGROUND
  There is a need for highly sensitive and specific laboratory tests for the early diagnosis of rheumatoid arthritis (RA). Anticitrullinated protein/peptide antibodies are produced in the sera of RA patients.
  
  
  OBJECTIVE
  To assess and discuss the diagnostic value of Orgentec antimutated citrullinated vimentin (anti-MCV) ELISA and to compare this diagnostic to commercially available anticyclic citrullinated peptide (anti-CCP) tests.
  
  
  METHODS
  The evaluation is based on our recently published study on the comparison of anti-MCV and anti-CCP2 tests, as well as on published studies.
  
  
  CONCLUSIONS
  In established RA, the anti-MCV ELISA exerts a specificity comparable with anti-CCP2. Numerous recent studies suggest that anti-MCV may have higher sensitivity, however there are also some publications stating the opposite. In early RA, anti-MCV may be a better predictor of disease activity and radiological progression than anti-CCP tests.
authors.affiliation: University of Debrecen, Medical and Health Science Centre, Institute of Medicine, Department of Rheumatology, 22 Moricz street, Debrecen, H-4032, Hungary +36 52 314 091 ; +36 52 414 489 ; szekanecz@iiibel.dote.hu.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szekanecz
authors.forename: Gabriella
authors.initials: G
authors.lastname: Lakos