title: Clinical trial evaluating color change and tooth sensitivity throughout and following in-office bleaching.
abstract: The aim of this study was to assess the color alteration and sensitivity of teeth throughout and following in-office bleaching. Twenty-two volunteers participated in this clinical trial of bleaching treatment (35% hydrogen peroxide bleaching gel and placebo) applied on maxillary incisors and canines. According to a split-mouth design, the volunteers' maxillary hemi-arches received either the bleaching or placebo agent, applied four times, at 1-week intervals. Color alteration and tooth sensitivity were assessed throughout and following bleaching. Statistical calculations were performed using gamma distribution and repeated-measures ANOVA. There was a statistically significant difference between teeth submitted to a bleaching agent and placebo (P < .001). At the end of the first, second, third, and fourth sessions, the bleached teeth presented color scores statistically lower than those observed immediately before bleaching. There was no difference in the color scale scores of the bleached teeth between bleaching sessions. The sensitivity data test showed a significant difference among treatments (P < .0001). Color alteration and dental sensitivity were altered by the bleaching agent.
authors.affiliation: Department of Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University, São Paulo, Brazil. lucassilveira1@yahoo.com.br
authors.forename: Lucas Silveira
authors.initials: LS
authors.lastname: Machado
authors.forename: Fernanda Garcia
authors.initials: FG
authors.lastname: de Oliveira
authors.forename: Eduardo Passos
authors.initials: EP
authors.lastname: Rocha
authors.forename: Paulo Henrique
authors.initials: PH
authors.lastname: dos Santos
authors.forename: André Luiz Fraga
authors.initials: AL
authors.lastname: Briso
authors.forename: Maria Lúcia Marçal Mazza
authors.initials: ML
authors.lastname: Sundefeld
authors.forename: Renato Herman
authors.initials: RH
authors.lastname: Sundfeld
mesh_terms: D000293:Adolescent; D000328:Adult; D003116:Color; D003481:Cuspid / Q000187:drug effects* / Q000473:pathology; D003807:Dentin Sensitivity / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage / Q000627:therapeutic use; D007180:Incisor / Q000187:drug effects* / Q000473:pathology; D010919:Placebos; D013997:Time Factors; D014073:Tooth Bleaching / Q000379:methods*; D058205:Tooth Bleaching Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D010919:Placebos; D058205:Tooth Bleaching Agents; D006861:Hydrogen Peroxide