title: Hematological alterations and thymic function in newborns of HIV-infected mothers receiving antiretroviral drugs.
abstract: OBJECTIVE
  To investigate the effects of antiretroviral (ARV) drugs on hematological parameters and thymic function in HIV-uninfected newborns of HIV-infected mothers.
  
  
  METHODS
  Cross sectional study.
  
  
  METHODS
  Chiang-Mai University Hospital, Chiang-Mai, Thailand.
  49 HIV-uninfected and 26 HIV-infected pregnancies.
  
  
  METHODS
  Cord blood samples of newborns from HIV-uninfected and HIV-infected mothers were collected. Hematological parameters were measured using automatic blood cell count. T-cell receptor excision circles (TRECs) levels in cord blood mononuclear cells (CBMCs), CD4+ and CD8+ T-cells were quantified using real-time PCR..
  
  
  METHODS
  Hemotological parameters and thymic function.
  
  
  RESULTS
  Newborn of HIV-infected mother tended to have lower mean levels of hemoglobin than those of HIV-uninfected mother (137 ±22 vs 146 ±17 g/L, P = 0.05). Furthermore, mean of red blood cell (RBC) counts and hematocrit and median of TRECs in CD4+ T-cells in the newborns of the former were significantly lower than those of the latter [3.6 ±0.7 vs 4.8 ±0.6 x 1012 cells/L, P <0.001; 0.40 ±0.07 vs 0.46 ±0.05 L/L, P < 0.001 and 0.53 (IQR: 0.03-5.76) vs 13.20 (IQR: 2.77-27.51) x 10-3 pg/uL, P = 0.02, respectively].
  
  
  CONCLUSIONS
  ARV drugs altered hematological parameters and thymic function (TRECs CD4+ T-cells) in HIV-uninfected newborns of HIV-infected mothers.
authors.affiliation: Department of Medical Technology, Faculty of Associated Medical Sciences, Research Institute for Health Sciences, Chiang-Mai University, Chiang-Mai, Thailand.
authors.forename: Rotjanee
authors.initials: R
authors.lastname: Wongnoi
authors.forename: Nawaporn
authors.initials: N
authors.lastname: Penvieng
authors.forename: Panthong
authors.initials: P
authors.lastname: Singboottra
authors.forename: Doungnapa
authors.initials: D
authors.lastname: Kingkeow
authors.forename: Peninnah
authors.initials: P
authors.lastname: Oberdorfer
authors.forename: Pannee
authors.initials: P
authors.lastname: Sirivatanapa
authors.forename: Sakorn
authors.initials: S
authors.lastname: Pornprasert
mesh_terms: D044966:Anti-Retroviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009035:Mothers; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology*; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D044966:Anti-Retroviral Agents; D006454:Hemoglobins