title: Regeneration of cirrhotic liver in rabbits after intrahepatic injection of cryoprecipitate.
abstract: The stimulatory effect of cryoprecipitate on liver regeneration was studied in rabbits with cirrhosis of the liver induced by subcutaneous injection of tetrachloromethane. Cryoprecipitate stimulated the hepatocyte regeneration (appearance of binuclear and proliferating cells) in liver tissue in cirrhosis, but the initial structure of the liver was not restored. The newly formed focus of regeneration with proper girder structure of hepatocytes forced back the connective tissue. Highly concentrated solution of fibrinogen, injected by puncture method into cirrhotic hepatic tissue, stimulated its regeneration.
authors.affiliation: Department of Faculty Surgery No. 1, Department of Pathological Anatomy, Therapeutic Faculty, I. M. Sechenov First Moscow State Medical University, Russia.
authors.forename: A F
authors.initials: AF
authors.lastname: Chernousov
authors.forename: T V
authors.initials: TV
authors.lastname: Khorobrykh
authors.forename: R V
authors.initials: RV
authors.lastname: Karpova
authors.forename: T P
authors.initials: TP
authors.lastname: Nekrasova
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride; D049109:Cell Proliferation; D005169:Factor VIII / Q000008:administration & dosage*; D005340:Fibrinogen / Q000008:administration & dosage*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D011817:Rabbits
chemical_list: C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005340:Fibrinogen; D002251:Carbon Tetrachloride