title: Role of endothelial dysfunction and lymphocyte-platelet adhesion in the pathogenesis of bile peritonitis.
abstract: Bile peritonitis is associated with endotoxemia, endothelial dysfunction, and increased level of pro-inflammatory cytokines. Under these conditions, serum concentration of NO metabolites (nitrate/nitrite ratio) and NO production by platelets significantly increase in animals with bile peritonitis, which reflects the development of inflammatory process and its antithrombotic activity, respectively. At the same time, platelet adhesion to lymphocytes increased in animals with bile peritonitis. The observed effect was confirmed by a direct correlation between the adhesion activity of lymphocytes to platelets and the content of desquamated endotheliocytes. This phenomenon played a crucial role in the development of protective and reparative processes in the damaged surface of vessel wall.
authors.affiliation: Department of Operative Surgery and Topographic Anatomy, Kuban State Medical University, Krasnodar, Russia. superego_ksmu@mail.ru
authors.forename: E A
authors.initials: EA
authors.lastname: Petrosyan
authors.forename: O A
authors.initials: OA
authors.lastname: Tereshenko
authors.forename: A A
authors.initials: AA
authors.lastname: Botashev
authors.forename: M A
authors.initials: MA
authors.lastname: Khasaeva
authors.forename: U V
authors.initials: UV
authors.lastname: Pomeshik
authors.forename: S G
authors.initials: SG
authors.lastname: Gubaz
authors.forename: V I
authors.initials: VI
authors.lastname: Sergienko
mesh_terms: D000818:Animals; D001792:Blood Platelets; D002448:Cell Adhesion / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D004285:Dogs; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D010538:Peritonitis / Q000378:metabolism / Q000473:pathology*
chemical_list: D016207:Cytokines; D009569:Nitric Oxide