title: Involvement of STAT3 in immune evasion during lung tumorigenesis.
abstract: In a recent study, we have shown that STAT3 expressed by tumor cells blunts antitumor immunity during carcinogen-induced lung tumorigenesis. STAT3 inhibits the production of pro-inflammatory chemokines and MHC Class I chain-related gene A. In contrast, STAT3 promotes the expression of MHC class I molecules. Consequently, STAT3 promotes tumor cell resistance to NK cell-mediated cytotoxicity.
authors.affiliation: Department of Respiratory Medicine, Allergy and Rheumatic Diseases; Osaka University Graduate School of Medicine; Suita, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kida
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ihara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kumanogoh
keywords: MHC Class I; MICA; NK cell; STAT3; antitumor immunity; lung; tumorigenesis