title: Localized Histoplasma capsulatum osteomyelitis of the fibula in an immunocompetent teenage boy: a case report.
abstract: BACKGROUND
  Infection of local bone with Histoplasma capsulatum is rare and difficult to diagnosis, and occurs particularly in immunocompetent subjects, who are more likely to be affected by a wide range of organisms.
  
  
  METHODS
  An 11-year-old boy presented with localized histoplasmosis osteomyelitis in the left fibula without any evidence of abnormal immunological function or systemic disease. After surgical clearance of the lesion and homologous cancellous bone, the patient was treated orally with voriconazole for 6 months. The patient completely recovered with full function of his left leg during the 5-year follow-up.
  
  
  CONCLUSIONS
  Histoplasmosis osteomyelitis can occasionally occur in immunocompetent individuals and can be complete cured by surgical clearance of the lesion and antibiotic treatment.
authors.affiliation: Department of Orthopedics, the Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jie Fang Road, Hangzhou, Zhejiang 310009, PR China.
authors.forename: Lu
authors.initials: L
authors.lastname: Huang
authors.forename: Yongping
authors.initials: Y
authors.lastname: Wu
authors.forename: Xudong
authors.initials: X
authors.lastname: Miao
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D005360:Fibula / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D006658:Histoplasma / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007121:Immunocompetence; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D011743:Pyrimidines / Q000627:therapeutic use; D011859:Radiography; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole