title: Duration of cisplatin excretion in breast milk.
abstract: Cisplatin, a platinum-based chemotherapy agent, is commonly used in treating cancers that may affect women of childbearing age, including cervical cancer, triple-negative breast cancer, and pediatric tumors in adolescents. The authors found that platinum was undetectable in breast milk at 66 hours and beyond following a 70-mg dose of intravenous cisplatin. Relative infant dose of platinum was calculated to be between 0.29% and 0.40% of the maternal dose corrected for body weight. This case demonstrates minimal exposure to platinum via breast milk, following a single 70-mg intravenous dose of cisplatin.
authors.affiliation: 1Department of Pharmacy, University of Washington, Seattle, WA, USA.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Hays
authors.forename: Rachel J
authors.initials: RJ
authors.lastname: Ryu
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Swisher
authors.forename: Eddie
authors.initials: E
authors.lastname: Reed
authors.forename: Terry
authors.initials: T
authors.lastname: McManus
authors.forename: Blanche
authors.initials: B
authors.lastname: Rybeck
authors.forename: William P
authors.initials: WP
authors.lastname: Petros
authors.forename: Mary F
authors.initials: MF
authors.lastname: Hebert
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D001942:Breast Feeding; D002945:Cisplatin / Q000032:analysis* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D008895:Milk, Human / Q000737:chemistry*; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
chemical_list: D002945:Cisplatin
keywords: breast milk; breastfeeding; cisplatin; human milk