title: Characterizing alcohol use disorders and suicidal ideation in young women.
abstract: OBJECTIVE
  Alcohol use disorders (AUDs) and suicidal ideation (SI) co-occur, yet few studies have investigated the risk and protective factors that infl uence their comorbidity.
  
  
  METHODS
  Data from 3,787 twin women ages 18`27 years were analyzed. AUD was defined as a lifetime history of alcohol abuse or dependence as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. SI was coded as a lifetime report of any SI, and all subjects were queried about SI. Subjects were divided into those with neither AUD nor SI (AUD-SI-), those with AUD but no SI (AUD+SI-), those with SI but no AUD (AUD-SI+), and those with comorbid AUD and SI (AUD+SI+). Association with multiple measures of psychopathology, negative life events, personality, and family history was assessed using multinomial logistic regression.
  
  
  RESULTS
  Women with AUD were at 3.1 (95% confidence interval [2.5, 3.8]) odds of also reporting a lifetime history of SI. Psychopathology and negative life events were consistently high in the AUD+SI+ group. AUD+SI+ women also were more likely to report drinking to cope. Substance use was more common in the AUD+SI- versus the AUD-SI+ women, whereas major depressive disorder, social phobia, and panic attacks were more commonly reported by the AUD-SI+ versus the AUD+SI- women.
  
  
  CONCLUSIONS
  The comorbidity between AUD and SI is characterized in young women by co-occurring psychopathology, drinking to cope, and negative life events.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA. arpana@wustl.edu
authors.forename: Arpana
authors.initials: A
authors.lastname: Agrawal
authors.forename: Anna M
authors.initials: AM
authors.lastname: Constantino
authors.forename: Kathleen K
authors.initials: KK
authors.lastname: Bucholz
authors.forename: Anne
authors.initials: A
authors.lastname: Glowinski
authors.forename: Pamela A F
authors.initials: PA
authors.lastname: Madden
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Heath
authors.forename: Michael T
authors.initials: MT
authors.lastname: Lynskey
mesh_terms: D000293:Adolescent; D000328:Adult; D019973:Alcohol-Related Disorders / Q000453:epidemiology*; D000437:Alcoholism / Q000453:epidemiology*; D003865:Major Depressive Disorder / Q000453:epidemiology; D005260:Female; D006801:Humans; D008016:Life Change Events; D016015:Logistic Models; D016584:Panic Disorder / Q000453:epidemiology; D010698:Phobic Disorders / Q000453:epidemiology; D012306:Risk; D059020:Suicidal Ideation; D014427:Twins; D055815:Young Adult