title: Nitrosothiol Signaling in Anoikis Resistance and Cancer Metastasis.
abstract: Nitric oxide (NO) has been widely recognized as an important cell-signaling molecule that regulates various physiological and pathological processes.S-nitrosylation, or covalent attachment of NO to protein sulfhydryl groups, is a key mechanism by which NO regulates protein functions and cellular processes. In this article we discuss the various roles of NO and protein nitrosylation in cancer development, with a focus on cell invasion and anoikis resistance, both of which are key determinants of cancer metastasis. We specially address some of the mechanisms by which NO-mediatedS-nitrosylation modulates substrates that have putative effects on key steps of metastasis. We propose that nitrosothiol signaling is a key regulatory mechanism common to several pathways involved in cancer progression and metastasis, and identifying such a mechanism will improve our understanding of the disease process and aid in the development of novel anticancer therapeutics.
authors.affiliation: Department of Pharmaceutical Sciences, Hampton University, Hampton, Virginia.
authors.forename: Sudjit
authors.initials: S
authors.lastname: Luanpitpong
authors.forename: Anand Krishnan V
authors.initials: AK
authors.lastname: Iyer
authors.forename: Neelam
authors.initials: N
authors.lastname: Azad
authors.forename: Liying
authors.initials: L
authors.lastname: Wang
authors.forename: Yon
authors.initials: Y
authors.lastname: Rojanasakul
keywords: S-nitrosylation; anoikis; cancer; invasion; metastasis; nitric oxide