title: The liver toxicity knowledge base: a systems approach to a complex end point.
abstract: Drug-induced liver injury (DILI) is a major concern in public health management, drug development, and regulatory implementation. The Liver Toxicity Knowledge Base (LTKB) was developed with the specific aim of enhancing our understanding of DILI. It seeks to achieve improvement in DILI prediction through integrated analysis of diverse sources of drug-elicited data. The project has also produced a centralized resource of data as well as predictive models that will be useful for research and drug regulation.
authors.affiliation: Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA.
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: R
authors.initials: R
authors.lastname: Kelly
authors.forename: G
authors.initials: G
authors.lastname: Zhou
authors.forename: H
authors.initials: H
authors.lastname: Fang
authors.forename: J
authors.initials: J
authors.lastname: Borlak
authors.forename: W
authors.initials: W
authors.lastname: Tong
mesh_terms: D035843:Biomedical Research / Q000379:methods; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000503:physiopathology; D016208:Databases, Factual; D015195:Drug Design; D004335:Drug and Narcotic Control; D064420:Drug-Related Side Effects and Adverse Reactions; D023381:Endpoint Determination; D006801:Humans; D008954:Models, Biological