title: Effect of AMPD1 gene polymorphism on muscle activity in humans.
abstract: Physical activity phenotypes are highly poligenic. Skeletal muscle-specific AMP deaminase isoform, encoded by AMPD1 gene, is stimulated after short-term highly intense exercise and is an important regulator of muscular energy metabolism in exercise. Analysis of restriction fragment length polymorphisms detected much lesser frequency of AMPD1 allele T and genotype TT in athletes engaged in the high-speed and strength sports (N=305) in comparison with humans practicing no sports (N=499). Hence, AMPD1 gene polymorphism C34T can be considered as a marker of liability to the high-speed and strength muscular activity.
authors.affiliation: St. Petersburg Institute of Physical Culture, Russia. o.fedotovska@mail.ru
authors.forename: O N
authors.initials: ON
authors.lastname: Fedotovskaya
authors.forename: A A
authors.initials: AA
authors.lastname: Danilova
authors.forename: I I
authors.initials: II
authors.lastname: Akhmetov
mesh_terms: D000659:AMP Deaminase / Q000235:genetics*; D000328:Adult; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D055815:Young Adult
chemical_list: D000659:AMP Deaminase; C514117:AMPD1 protein, human