title: Production of early IL-1β induced by human serum γ-globulin metal complexes.
abstract: Plasma γ-globulin fraction proteins, copper and zinc cations, and metal complexes formed by them with human serum γ-globulin induce the production of early (24-h incubation) IL-1β by human blood cells. The protein modified by Zn cations 1.2 times more actively (p<0.01) induced early IL-1β than the control γ-globulin, while γ-globulin metal complex with copper was 1.4 times less active (p<0.1) than the control protein. The regularities of induction changed over the course of 48-h incubation: zinc cations chelated by γ-globulin fraction protein reduced, while copper cations stimulated the realization of the protein induction potential in the metal complex.
authors.affiliation: Laboratory of Cell-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Ministry of Health and Social Development of Russia, Moscow, Russia. cheknev@gamaleya.org
authors.forename: S B
authors.initials: SB
authors.lastname: Cheknev
authors.forename: I E
authors.initials: IE
authors.lastname: Efremova
authors.forename: L S
authors.initials: LS
authors.lastname: Piskovskaya
authors.forename: E N
authors.initials: EN
authors.lastname: Yushkovets
authors.forename: A A
authors.initials: AA
authors.lastname: Babajanz
mesh_terms: D002478:Cells, Cultured; D056831:Coordination Complexes / Q000097:blood*; D003300:Copper / Q000097:blood / Q000378:metabolism*; D006801:Humans; D053583:Interleukin-1beta / Q000096:biosynthesis / Q000097:blood*; D015032:Zinc / Q000097:blood / Q000378:metabolism*; D005719:gamma-Globulins / Q000378:metabolism*
chemical_list: D056831:Coordination Complexes; D053583:Interleukin-1beta; D005719:gamma-Globulins; D003300:Copper; D015032:Zinc