title: Diversified pattern of the human colorectal cancer microbiome.
abstract: BACKGROUND
  The aim of this study is to expand existing knowledge about the CRC-associated microbiome among Han Chinese, and to further discover the variation pattern of the human CRC microbiome across all population.
  
  
  RESULTS
  Using pyrosequencing-based molecular monitoring of bacterial 16S rRNA gene from eight tumor/normal tissue pairs of eight Chinese CRC patients, we analyzed and characterized the basic features of the CRC-associated microbiome. Firstly, we discovered an increasing diversity among tumor-associated bacterial communities. Secondly, in 50% of Chinese CRC patients, we found a significant increase of Roseburia (P = 0.017), and a concurrent decrease of both Microbacterium (P = 0.009) and Anoxybacillus (P = 0.009) in tumor tissue.
  
  
  CONCLUSIONS
  We discovered a novel CRC microbiome pattern in Chinese. Both the over-represented Roseburia bacteria at tumor sites and the over-represented Microbacterium and Anoxybacillus bacteria away from tumor sites were both closely related in Chinese CRC patients. Across several populations reported in this study and previously, we observed both common and distinctive patterns of human CRC microbiome's association with a high-risk of CRC.
authors.affiliation: Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming, 650032, China.|State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Geng
authors.affiliation: Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Gastroenterology, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
authors.forename: Huiqin
authors.initials: H
authors.lastname: Zhai
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhang