title: Potential of surface acoustic wave biosensors for early sepsis diagnosis.
abstract: Early diagnosis of sepsis is a difficult problem for intensivists and new biomarkers for early diagnosis have been difficult to come by. Here we discuss the potential of adapting a technology from the electronics industry, surface acoustic wave (SAW) sensors, for diagnosis of multiple markers of sepsis in real time, using non-invasive assays of exhaled breath condensate. The principles and advantages of the SAW technology are reviewed as well as a proposed plan for adapting this flexible technology to early sepsis detection.
authors.forename: Marie
authors.initials: M
authors.lastname: Csete
authors.forename: William D
authors.initials: WD
authors.lastname: Hunt
mesh_terms: D000162:Acoustics; D015415:Biomarkers / Q000737:chemistry; D015374:Biosensing Techniques; D001944:Breath Tests; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation / Q000379:methods; D008070:Lipopolysaccharides / Q000378:metabolism; D008991:Monitoring, Physiologic / Q000379:methods; D009991:Oscillometry / Q000379:methods; D019095:Point-of-Care Systems; D011506:Proteins / Q000032:analysis; D018805:Sepsis / Q000175:diagnosis*; D013499:Surface Properties; D013997:Time Factors
chemical_list: D015415:Biomarkers; D008070:Lipopolysaccharides; D011506:Proteins