title: [Genetic polymorphism affects the clinical effects of opioids after surgery].
abstract: Post-operative pain-management (PPM) should first of all be decided by the specific surgical procedure in each case, but it also seems that genetic polymorphism affects the clinical effects of the pharmacological treatment. In this article we summarize the existing evidence of the hypothesis that the A118G-variant of the µ-opioidreceptor-gene OPRM1 affects clinical response to opioids after gynaecological and abdominal surgery. If the genetic profile of each patient becomes easier accessible in the future, PPM might be planned accordingly to surgical procedure as well as to genetic profile to avoid post-operative pain and pharmacological adverse effects.
authors.affiliation: Anæstesiologisk Afdeling I, Herlev Hospital, Denmark. andreas.fryd@get2net.dk
authors.forename: Andreas
authors.initials: A
authors.lastname: Frydshou
authors.forename: Egon Godthåb
authors.initials: EG
authors.lastname: Hansen
authors.forename: Ismail
authors.initials: I
authors.lastname: Gögenur
mesh_terms: D000005:Abdomen / Q000601:surgery; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy / Q000235:genetics* / Q000517:prevention & control; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017450:Receptors, Opioid, mu / Q000235:genetics*
chemical_list: D000701:Analgesics, Opioid; C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu