title: Voriconazole induced bradycardia.
abstract: Voriconazole is a triazole antifungal drug that is used to treat invasive fungal infections, especially aspergillus. Here, we report two children who had severe bradycardia associated with voriconazole at a dose of 12 mg/kg per day. Bradycardia resolved in 24 hours in both after decreasing the dose to 10 mg/kg per day. Heart rates were in normal limits on follow-up. Bradycardia may be a side effect of voriconazole treatment in children under immunosuppressive treatment. Heart rate should be monitored in patients receiving voriconazole and other triazole treatments.
authors.affiliation: 1Department of Pediatric Hematology-Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Uludağ
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozdemir
authors.forename: Gülen
authors.initials: G
authors.lastname: Tüysüz
authors.forename: Ayşe Güler
authors.initials: AG
authors.lastname: Eroğlu
authors.forename: Tiraje
authors.initials: T
authors.lastname: Celkan
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001228:Aspergillosis / Q000188:drug therapy*; D001919:Bradycardia / Q000151:congenital* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors; D014230:Triazoles / Q000008:administration & dosage / Q000009:adverse effects*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole