title: Structural and Physicochemical Aspects of Dasatinib Hydrate and Anhydrate phases.
abstract: Crystal structures for the commercial monohydrate form and an anhydrate form of dasatinib, an oral anti-cancer agent, are presented along with characterization by Raman spectroscopy, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. Solubility measurements conducted in water reveal the anhydrate has dramatically improved solubility compared to the commercial hydrate form. Finally, dasatinib is a rare example of a promiscuous solvate former and the basis for this behavior can now be understood by examining the poor packing efficiency in the unsolvated form.
authors.affiliation: Department of Chemistry and the Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, Michigan- 48109, United States.
authors.forename: Saikat
authors.initials: S
authors.lastname: Roy
authors.forename: Rosalynn
authors.initials: R
authors.lastname: Quiñones
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Matzger