title: Association of angiotensin-converting enzyme (ACE) and fatty acid binding protein 2 (FABP2) genes polymorphism with type 2 diabetes mellitus in Northern India.
abstract: BACKGROUND
  Type 2 diabetes mellitus (T2DM) is growing in an epidemic manner across the world with an expected doubling of the incidence to millions of affected individuals in the last decades. At present, adequate data are not available regarding the ACE and FABP2 polymorphisms and their susceptibility with T2DM cases in the North Indian population. Thus we conceived the need for further study of ACE (I/D) and FABP2 (Ala54Thr) genes polymorphism and its susceptibility to T2DM in the North Indian population.
  
  
  METHODS
  In this study, a total of 300 subjects (including 190 T2DM cases and 110 controls) participated. ACE and FABP2 gene polymorphisms in the cases and controls were evaluated by polymerase chain reaction and restriction fragment length polymorphism.
  
  
  RESULTS
  The frequencies of ACE I/I, I/D and D/D genotypes in T2DM cases and controls were 28.73%, 55.17%, 16.09% and 13.63%, 57.95%, 28.40%, respectively. The frequencies of FABP2 Ala54Ala, Ala54Thr and Thr54Thr in T2DM cases were 18.39%, 66.66%, 14.94% and 22.72%, 61.36%, 15.90% in controls, respectively. ACE I/I genotype was significantly more frequent in cases as compared to controls (p = 0.003, χ(2) = 9.13).
  
  
  CONCLUSIONS
  It appears that the ACE I/I genotype frequency was significantly higher in the T2DM cases as compared to the controls.
authors.affiliation: Department of Biochemistry, Era's Lucknow Medical College and Hospital, India tasleem24@gmail.com.
authors.forename: Syed Tasleem
authors.initials: ST
authors.lastname: Raza
authors.affiliation: Department of Medicine, Era's Lucknow Medical College and Hospital, India.
authors.forename: Jalees
authors.initials: J
authors.lastname: Fatima
authors.affiliation: Department of Biochemistry, Era's Lucknow Medical College and Hospital, India.
authors.forename: Faisal
authors.initials: F
authors.lastname: Ahmed
authors.affiliation: Department of Biochemistry, Era's Lucknow Medical College and Hospital, India.
authors.forename: Shania
authors.initials: S
authors.lastname: Abbas
authors.affiliation: Department of Statistics, Era's Lucknow Medical College and Hospital, India.
authors.forename: Zeashan Haider
authors.initials: ZH
authors.lastname: Zaidi
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Integral University Lucknow, India.
authors.forename: Seema
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, Era's Lucknow Medical College and Hospital, India.
authors.forename: Farzana
authors.initials: F
authors.lastname: Mahdi
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004587:Electrophoresis, Agar Gel; D005006:Ethnicity / Q000235:genetics; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; D007703:Peptidyl-Dipeptidase A
keywords: ACE; FABP2; T2DM; genetic polymorphism; genetic susceptibility