title: Epidemiological determinants of successful vaccine development.
abstract: Epidemiological determinants of successful vaccine development were explored using measurable biological variables including antigenic stability and requirement of T-cell immunity. Employing a logistic regression model, we demonstrate that a high affinity with blood and immune cells and pathogen interactions (e.g. interference) would be the risk factors of failure for vaccine development.
authors.affiliation: School of Public Health, The University of Hong Kong, Level 6, Core F, Cyberport 3, 100 Cyberport Road, Pokfulam, Hong Kong SAR, China. nishiurah@gmail.com
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishiura
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizumoto
mesh_terms: D002648:Child; D002675:Child, Preschool; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D016233:Immunotherapy, Active; D007223:Infant; D007231:Infant, Newborn; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination; D014612:Vaccines / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D014612:Vaccines
keywords: Vaccination; epidemiology; immunization; infectious disease; statistical model.