title: Bone metastases radiopharmaceuticals: an overview.
abstract: The skeleton is one of the preferential sites for metastases of solid tumors, and metastatic disease is the most common malignancy of the bone. Diagnosis and evaluation of skeletal metastases require more frequently a combined approach of different diagnostic methods. Between the currently available imaging modalities, a major role is devoted to two radionuclide functional techniques namely scintigraphy and positron emission tomography (PET) imaging. Both these techniques require the use of different radiopharmaceuticals. The aim of this paper is to review the most important radiocompounds that can be successfully used to detect and/or characterize bone metastases.
authors.affiliation: Department of Radiological Sciences - Second University of Naples, Naples, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cuccurullo
authors.forename: Giuseppe Lucio
authors.initials: GL
authors.lastname: Cascini
authors.forename: Oscar
authors.initials: O
authors.lastname: Tamburrini
authors.forename: Antonio
authors.initials: A
authors.lastname: Rotondo
authors.forename: Luigi
authors.initials: L
authors.lastname: Mansi
mesh_terms: D019797:3-Iodobenzylguanidine; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D002794:Choline; D004295:Dihydroxyphenylalanine; D004164:Diphosphonates; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007457:Iodine Radioisotopes; D049268:Positron-Emission Tomography / Q000379:methods*; D016719:Radioimmunodetection / Q000379:methods*; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride; D013004:Somatostatin / Q000031:analogs & derivatives; D013667:Technetium; D013936:Thymidine; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D004164:Diphosphonates; D005462:Fluorine Radioisotopes; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D019797:3-Iodobenzylguanidine; D013004:Somatostatin; D004295:Dihydroxyphenylalanine; D013667:Technetium; D012969:Sodium Fluoride; D002794:Choline; D013936:Thymidine