title: [Effects of compound danshen tablet on the expression of Abeta in transgenic cell model of Alzheimer's disease].
abstract: OBJECTIVE
  To study the effects of Compound Danshen Tablet (CDT) on the expression of the beta-amyloid peptide (Abeta) in transgenic cell model of Alzheimer's disease (AD).
  
  
  METHODS
  The previously successfully cultured transgenic cell model was used as AD transgenic cell model. Rats were fed with 0.5, 1, 2, and 4 times CDT. The AD transgenic cells were cultured in 0.5, 1, 2, and 4 times rats' sera. The expressions of Abeta in transgenic cells were detected using Western blot.
  
  
  RESULTS
  The optimal dose effect was obtained in the 1 time CDT group at 24 h.
  
  
  CONCLUSIONS
  CDT could reduce the Abeta expression level in the AD transgenic cell model.
authors.affiliation: Department of Neurology, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007.
authors.forename: Hua
authors.initials: H
authors.lastname: Hu
authors.forename: De-sheng
authors.initials: DS
authors.lastname: Zhou
authors.forename: Rong
authors.initials: R
authors.lastname: Yu
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza / Q000737:chemistry; D019076:Transgenes
chemical_list: D016229:Amyloid beta-Peptides; D004365:Drugs, Chinese Herbal