title: Diabetes mellitus and inflammation.
abstract: Type 2 diabetes mellitus (T2DM) is increasingly common worldwide. Related complications account for increased morbidity and mortality, and enormous healthcare spending. Knowledge of the pathophysiological derangements involved in the occurrence of diabetes and related complications is critical for successful prevention and control solutions. Epidemiologic studies have established an association between inflammatory biomarkers and the occurrence of T2DM and complications. Adipose tissue appears to be a major site of production of those inflammatory biomarkers, as a result of the cross-talk between adipose cells, macrophages, and other immune cells that infiltrate the expanding adipose tissue. The triggering mechanisms of the inflammation in T2DM are still ill-understood. Inflammatory response likely contributes to T2DM occurrence by causing insulin resistance, and is in turn intensified in the presence of hyperglycemia to promote long-term complications of diabetes. Targeting inflammatory pathways could possibly be a component of the strategies to prevent and control diabetes and related complications.
authors.affiliation: Laboratory for Molecular and Metabolic Diseases, Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon.
authors.forename: Eric
authors.initials: E
authors.lastname: Lontchi-Yimagou
authors.forename: Eugene
authors.initials: E
authors.lastname: Sobngwi
authors.forename: Tandi E
authors.initials: TE
authors.lastname: Matsha
authors.forename: Andre Pascal
authors.initials: AP
authors.lastname: Kengne
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000266:history / Q000473:pathology*; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000266:history / Q000473:pathology* / Q000517:prevention & control; D018836:Inflammation Mediators / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000473:pathology; D009928:Organ Specificity
chemical_list: D018836:Inflammation Mediators