title: Influence of GABA on brain protein synthesis mediated by the mammalian target on the rapamycin pathway.
abstract: This study determined the influence of γ-aminobutyric acid (GABA) on brain protein synthesis via the mammalian target of rapamycin (mTOR) pathway. Experiments were carried out on three groups of 6-wk-old male rats with 0%, 0.5%, and 1% GABA. The percentage-phosphorylated S6K1 and growth hormone (GH) concentration was significantly increased by the GABA administration. The insulin level was not significantly changed, while the insulin-like growth factor 1 (IGF-1) level was significantly decreased by the GABA administration.
authors.affiliation: Laboratory of Nutritional Biochemistry and Global COE Program, School of Food and Nutritional Sciences, University of Shizuoka, Japan.
authors.forename: Panicha
authors.initials: P
authors.lastname: Thanapreedawat
authors.forename: Miho
authors.initials: M
authors.lastname: Ohsumi
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Hayase
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Yoshizawa
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Yokogoshi
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D005680:gamma-Aminobutyric Acid; D058570:TOR Serine-Threonine Kinases