title: Isolation and identification of a new anti-inflammatory cyathane diterpenoid from the medicinal fungus Cyathus hookeri Berk.
abstract: A new cyathane diterpene, named as cyathin I (1), as well as two known cyathane diterpenes (12R)-11a,14a-epoxy-13a,14b,15-trihydroxycyath-3-ene (2) and erinacine I (3), were isolated from the liquid culture of Cyathus hookeri Berk. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-3 showed inhibition against nitric oxide production in macrophages with an IC50 value of 15.5, 52.3, and 16.8 μM, respectively.
authors.affiliation: School of Business Administration, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Xu
authors.forename: Sha
authors.initials: S
authors.lastname: Yan
authors.forename: Kaishun
authors.initials: K
authors.lastname: Bi
authors.forename: Junjie
authors.initials: J
authors.lastname: Han
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhiang
authors.initials: Z
authors.lastname: Wu
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Chen
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D055365:Cyathus / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D007249:Inflammation / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*
chemical_list: D000893:Anti-Inflammatory Agents; D001688:Biological Products; D004224:Diterpenes; C497675:cyathane; C584386:cyathin I; C421185:erinacine I; D009569:Nitric Oxide