title: [Genetic polymorphisms of 18 STR loci in Uygur population of Kashi Prefecture of Xinjiang].
abstract: OBJECTIVE
  To investigate the genetic polymorphisms of 18 STR loci (D18S51, D21S11, D3S1358, FGA, D8S1179, upsilonWA, CSF1PO, D16S539, D7S820, D13S317, D5S818, D2S1338, D19S433, D12S391, TPOX, TH01, Penta E and D6S1043) in unrelated Uygur individuals in Kashi prefecture of Xinjiang and to explore the application value in forensic practice.
  
  
  METHODS
  Blood samples from 1 381 unrelated Uygur individuals were amplified by using DNA Typer 15 Plus kit. The amplified products were detected by using 3130XL Genetic Analyzer and the genotyping was done by using GeneMapper ID v3.2. Population genetics parameters were calculated and compared with that of the other population. The genetic distance of Reynold's was calculated and phylogenetic tree was constructed at last.
  
  
  RESULTS
  Of the 1 381 unrelated Uygur individuals, 231 alleles were detected, with an allele frequency of 0.0004-0.5304. The H values were 0.644-0.923, PIC values were 0.587-0.918, and DP values were 0.817-0.988, respectively, with a CPE > 0.9999999. The genetic distance was the longest (0.088 3) to Guangzhou Han population and the closest (0.0503) to Greek.
  
  
  CONCLUSIONS
  The 18 STR loci in the Uygur population of Kashi prefecture of Xinjiang have high genetic polymorphisms which are close to Europeans, and can be satisfied as genetic markers of population individual identification and paternity testing.
authors.affiliation: Department of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Wei-Xia
authors.initials: WX
authors.lastname: Weng
authors.forename: Chang-Hui
authors.initials: CH
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Tang
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China / Q000208:ethnology; D053803:Forensic Genetics / Q000379:methods; D005787:Gene Frequency / Q000235:genetics*; D056426:Genetic Loci; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic