title: [Evaluation of transdermal property in vitro of different breviscapine lipid carrier gels].
abstract: OBJECTIVE
  To prepare four breviscapine lipid carrier gels and general gel, and to study the transdermal promotive effects of them in vitro.
  
  
  METHODS
  Improved Franz-type diffusion cell and isolated rat skin were used as transdermal barrier, and the transdermal property was fitted by pharmacokinetics equations. The unit area cumulative permeation quantity of breviscapine was determined by HPLC method.
  
  
  RESULTS
  The 24 hours' unit area cumulative permeation quantity of SLN gel was the highest, followed in descending order were transfersomal gel, liposomal gel, NLC gel and general gel. The transdermal property in vitro of SLN gel fitted in with Higuchi pharmacokinetics equation.
  
  
  CONCLUSIONS
  The lipid carrier gels had different transdermal promotive effects to breviscapine, SLN gel was the best one as breviscapine transdermal carrier.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. huanhuanleslie@sina.com
authors.forename: Xin
authors.initials: X
authors.lastname: Xiong
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Xu
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Yin
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Chen
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D008055:Lipids / Q000737:chemistry*; D008297:Male; D051379:Mice; D012869:Skin Absorption
chemical_list: D004337:Drug Carriers; D005419:Flavonoids; D008055:Lipids; C061097:breviscapine