title: Exercise-induced changes in iron status and hepcidin response in female runners.
abstract: OBJECTIVE
  Exercise-induced iron deficiency is a common finding in endurance athletes. It has been suggested recently that hepcidin may be an important mediator in this process.
  
  
  OBJECTIVE
  To determine hepcidin levels and markers of iron status during long-term exercise training in female runners with depleted and normal iron stores.
  
  
  METHODS
  Fourteen runners were divided into two groups according to iron status. Blood samples were taken during a period of eight weeks at baseline, after training and after ten days' recovery phase.
  
  
  RESULTS
  Of 14 runners, 7 were iron deficient at baseline and 10 after training. Hepcidin was lower at recovery compared with baseline (p<0.05). The mean cell haemoglobin content, haemoglobin content per reticulocyte and total iron binding capacity all decreased, whereas soluble transferrin receptor and hypochromic red cells increased after training and recovery (p<0.05 for all).
  
  
  CONCLUSIONS
  The prevalence of depleted iron stores was 71% at the end of the training phase. Hepcidin and iron stores decreased during long-term running training and did not recover after ten days, regardless of baseline iron status.
authors.affiliation: Faculty of Sport, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Irena
authors.initials: I
authors.lastname: Auersperger
authors.forename: Branko
authors.initials: B
authors.lastname: Škof
authors.forename: Bojan
authors.initials: B
authors.lastname: Leskošek
authors.forename: Bojan
authors.initials: B
authors.lastname: Knap
authors.forename: Aleš
authors.initials: A
authors.lastname: Jerin
authors.forename: Mitja
authors.initials: M
authors.lastname: Lainscak
mesh_terms: D000328:Adult; D056352:Athletes; D015415:Biomarkers / Q000097:blood; D015444:Exercise; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000378:metabolism; D007501:Iron / Q000097:blood*; D000090463:Iron Deficiencies; D011446:Prospective Studies; D011485:Protein Binding; D012156:Reticulocytes / Q000378:metabolism; D012420:Running; D013997:Time Factors
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D064451:Hepcidins; D015850:Interleukin-6; D007501:Iron