title: Phase transfer-catalyzed synthesis of highly acrylated hyaluronan.
abstract: Glycosaminoglycans and its derivatives have gained increasing attention for the fabrication of hydrogels usable in biomedicine. Starting from high molecular weight hyaluronan, a natural glycosaminoglycan that forms a mayor component of the native extracellular matrix, we present an efficient phase-transfer-based synthesis for low molecular weight hyaluronan acrylates with a tailored degree of substitution (DS) ranging up to DS values of 1.7. The ability of these compounds to form dimensionally stable hydrogels was proven using different photo-initiator systems.
authors.affiliation: INNOVENT e.V., Biomaterials Department, Prüssingstr. 27B, D-07745 Jena, Germany.
authors.forename: Jana
authors.initials: J
authors.lastname: Becher
authors.forename: Stephanie
authors.initials: S
authors.lastname: Möller
authors.forename: Matthias
authors.initials: M
authors.lastname: Schnabelrauch
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D006820:Hyaluronic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry; D008027:Light; D008422:Materials Testing; D008970:Molecular Weight; D044367:Phase Transition; D011135:Polysaccharides, Bacterial / Q000737:chemistry; D013291:Streptococcus / Q000737:chemistry
chemical_list: D000179:Acrylates; D003432:Cross-Linking Reagents; D011135:Polysaccharides, Bacterial; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C026200:acryloyl chloride; D006820:Hyaluronic Acid