title: [Pregnancy-Associated Breast Cancer: An analytical observational study].
abstract: OBJECTIVE
  Pregnancy-associated breast cancer is defined as breast cancer diagnosed during pregnancy and up to one year postpartum.
  
  
  METHODS
  A retrospective, analytical, observational study comparing 56 cases of breast cancer and pregnancy (PABC) diagnosed 1976-2008 with 73 patients with breast cancer not associated with pregnancy (non-PABC) was performed. Demographic data, prognostic factors, treatment and survival were reviewed and compared.
  
  
  RESULTS
  The prevalence of PABC in our center is 8.3/10,000. The highest frequency (62%) appeared during the postpartum period. The stages are higher in PABC, being 31.3% advanced (EIII and EIV) in PABC versus 13.3% in non-PABC (P < .05). Regarding prognostic factors, 27.3% in PABC had a tumoral grade 3 versus 15.8% of non-PABC. Among women with PABC, 33.3% had negative estrogen receptors, 48.7% negative progesterone receptors and 34.5% positive Her2Neu compared with 22.2, 24.1 and 31%, respectively of non-PABC patients. Finally, positive lymph nodes were found in 52.8% of PABC, versus 33.8% non-PABC (P < .05). Overall and disease-free survival rate at 5 years for PABC was 63.7 and 74.2%, respectively.
  
  
  CONCLUSIONS
  The poorer survival observed is possibly due to the presence of adverse prognostic features such as lymph node metastases, negative hormone receptors, tumoral grade iii, as well as a delay in diagnosis with a higher rate of advanced stages.
authors.affiliation: Unidad de Ginecología Oncológica y Mastología, Departamento de Obstetricia, Ginecología y Reproducción Humana, Institut Universitari Dexeus, Barcelona, España. Electronic address: sonbau@dexeus.com.
authors.forename: Sonia
authors.initials: S
authors.lastname: Baulies
authors.affiliation: Unidad de Ginecología Oncológica y Mastología, Departamento de Obstetricia, Ginecología y Reproducción Humana, Institut Universitari Dexeus, Barcelona, España.
authors.forename: Maite
authors.initials: M
authors.lastname: Cusidó
authors.affiliation: Departamento de Anatomía Patológica, Institut Universitari Dexeus, Barcelona, España.
authors.forename: Francisco
authors.initials: F
authors.lastname: Tresserra
authors.affiliation: Unidad de Epidemiología y Estadística, Departamento de Obstetricia, Ginecología y Reproducción Humana, Institut Universitari Dexeus, Barcelona, España.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodríguez
authors.affiliation: Unidad de Diagnóstico Ginecológico por la Imagen, Departamento de Obstetricia, Ginecología y Reproducción Humana, Institut Universitari Dexeus, Barcelona, España.
authors.forename: Belén
authors.initials: B
authors.lastname: Ubeda
authors.affiliation: Unidad de Ginecología Oncológica y Mastología, Departamento de Obstetricia, Ginecología y Reproducción Humana, Institut Universitari Dexeus, Barcelona, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Ara
authors.affiliation: Unidad de Ginecología Oncológica y Mastología, Departamento de Obstetricia, Ginecología y Reproducción Humana, Institut Universitari Dexeus, Barcelona, España.
authors.forename: Rafael
authors.initials: R
authors.lastname: Fábregas
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D011644:Puerperal Disorders / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor
keywords: Breast cancer; Cáncer de mama; Embarazo; Factores pronósticos; Management; Pregnancy; Prognostic factors; Tratamiento