title: Disseminated intravascular coagulation in a dog naturally infected by Leishmania (Leishmania) chagasi from Rio de Janeiro - Brazil.
abstract: BACKGROUND
  Disseminated intravascular coagulation (DIC) is an acquired disorder characterized by the activation of intravascular coagulation and excessive fibrin formation. It always occurs in association with other clinical conditions, including parasitic diseases. DIC has been described as a unusual complication in human and canine visceral leishmaniasis.
  
  
  METHODS
  DIC was found in a seven-year-old male mongrel dog naturally infected by Leishmania (Leishmania) chagasi. Haemostasis parameters demonstrated changes in primary and secondary haemostasis and fibrinolysis.
  
  
  CONCLUSIONS
  DIC is a unusual condition described in canine visceral leishmaniasis and it seems to be associated with several immunological and pathological mechanisms involved in the disease.
authors.affiliation: Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz (Fiocruz), Av, Brasil, 4365, Manguinhos, Rio de Janeiro 21045-900, Brasil. carlahonse@yahoo.com.br
authors.forename: Carla O
authors.initials: CO
authors.lastname: Honse
authors.forename: Fabiano B
authors.initials: FB
authors.lastname: Figueiredo
authors.forename: Nayro X
authors.initials: NX
authors.lastname: de Alencar
authors.forename: Maria de Fátima
authors.initials: Mde F
authors.lastname: Madeira
authors.forename: Isabella D F
authors.initials: ID
authors.lastname: Gremião
authors.forename: Tânia M P
authors.initials: TM
authors.lastname: Schubach
mesh_terms: D000818:Animals; D001938:Brazil; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000469:parasitology* / Q000473:pathology; D004285:Dogs; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D008297:Male