title: Cutaneous carcinoma of the head and neck with clinical features of perineural infiltration treated with radiotherapy.
abstract: OBJECTIVE
  To review the outcome of patients with non-melanomatous carcinoma of the skin of the head and neck with perineural infiltration (PNI) with clinical features treated with radiotherapy.
  
  
  METHODS
  Between 1991 and 2004, 56 patients with non-melanomatous skin carcinoma with PNI with clinical features were identified from the institution's oncology database. All patients had radiotherapy as either definitive or adjuvant treatment. The factors that affected outcome were analysed. The primary end point was the 5 year relapse-free survival (RFS) from the time of diagnosis of PNI.
  
  
  RESULTS
  The overall 5 year RFS for the whole group was 48%. Squamous histology had a more unfavourable outcome than basal cell histology (5 year RFS: 39% versus 80%; P = 0.07). Tumours located in the distribution of the cranial nerves V1 and V2 had a worse outcome than tumours at other sites (5 year RFS: 33% versus 72%, P = 0.056). Those with multiple cranial nerve involvement did worse than those with single nerve involvement (27% versus 62%, P = 0.1). The pattern of relapse was predominantly local (87%), with a low rate (15%) of successful salvage.
  
  
  CONCLUSIONS
  Radiotherapy with or without surgery is curative in about half head and neck cutaneous non-melanomatous carcinomas with clinical PNI. The frequent local failure suggests that improvements in local treatment are required.
authors.affiliation: Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. Charles_Lin@health.qld.gov.au
authors.forename: Charles
authors.initials: C
authors.lastname: Lin
authors.forename: Lee
authors.initials: L
authors.lastname: Tripcony
authors.forename: Jacqui
authors.initials: J
authors.lastname: Keller
authors.forename: Michael
authors.initials: M
authors.lastname: Poulsen
authors.forename: Graeme
authors.initials: G
authors.lastname: Dickie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010525:Peripheral Nerves / Q000473:pathology*; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D000077195:Squamous Cell Carcinoma of Head and Neck; D016896:Treatment Outcome