title: [Genetic polymorphisms of the dinucleotide STR locus D6S261].
abstract: OBJECTIVE
  To investigate the application of dinucleotide STR locus in paternity testing.
  
  
  METHODS
  Dinucleotide STR locus D6S261 was selected and the paternity testing blood samples were amplified using 200 random blood samples, 16 family samples and 193 paternity test samples. Data of the PCR products were collected by 3130XL Genetic Analyzer and the genetic parameters of population were calculated by PowerStats v12.
  
  
  RESULTS
  Fifteen alleles and 50 genotypes were found and H, DP, PE and PIC were 0.850, 0.953, 0.695, and 0.820, respectively. The typing results of both family samples and paternity test samples were accord with the law of inheritance, which no mutation was discovered.
  
  
  CONCLUSIONS
  The genetic polymorphisms of D6S261 show good characteristics with low mutation rate and high stability. It can be an effective method to solve the indetermination caused by mutation in paternity testing if the stutter bands can be decreased.
authors.affiliation: Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Liu
authors.forename: Yan-Chai
authors.initials: YC
authors.lastname: Nie
authors.forename: Huai-Gu
authors.initials: HG
authors.lastname: Zhou
authors.forename: Zi-Qin
authors.initials: ZQ
authors.lastname: Zhao
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001483:Base Sequence; D053803:Forensic Genetics / Q000379:methods*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D009711:Nucleotides / Q000235:genetics*; D010334:Paternity; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic
chemical_list: D009711:Nucleotides