title: Nitric oxide signaling in the brain: a new target for inhaled nitric oxide?
abstract: Nitric oxide (NO) is a powerful vasodilator, involved in both physiological functions and pathophysiological alterations of various regulatory processes, for example, the maintenance of vascular tone and inflammation. The recently demonstrated impact of exogenous NO on the central nervous system extends its role under normal and pathological conditions. At times neuroprotective, at times neurotoxic, NO is capable of different effects depending upon the extent of cerebral damage, the cellular redox state, and the spatiotemporal coordinates and concentration at which it is synthesized. This review provides new insights into the short- and long-term effects of endogenous and exogenous NO in brain injury.
authors.affiliation: Paris Diderot University, Sorbonne Paris Cité, INSERM U676, Paris, France; PremUP Foundation.
authors.forename: Christiane
authors.initials: C
authors.lastname: Charriaut-Marlangue
authors.forename: Philippe
authors.initials: P
authors.lastname: Bonnin
authors.forename: Hoa
authors.initials: H
authors.lastname: Pham
authors.forename: Gauthier
authors.initials: G
authors.lastname: Loron
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Leger
authors.forename: Pierre
authors.initials: P
authors.lastname: Gressens
authors.forename: Sylvain
authors.initials: S
authors.lastname: Renolleau
authors.forename: Olivier
authors.initials: O
authors.lastname: Baud
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D001930:Brain Injuries / Q000188:drug therapy / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000008:administration & dosage*; D052248:Nitric Oxide Synthase Type I / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide; D052248:Nitric Oxide Synthase Type I