title: A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling-isomerization-condensation reaction.
abstract: A novel Pd/Cu catalyzed domino reaction for the synthesis of functionalized pyrrolo[1,2-b]pyridazines from readily accessible (hetero)aryl propargyl alcohols and 1-amino-2-bromopyrroles was developed. This cascade process involves a Sonogashira cross-coupling reaction, an isomerization and an intramolecular condensation.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Cun
authors.initials: C
authors.lastname: Tan
authors.forename: Qian
authors.initials: Q
authors.lastname: He
authors.forename: Yuyuan
authors.initials: Y
authors.lastname: Xie
authors.forename: Chunhao
authors.initials: C
authors.lastname: Yang
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D054879:Halogenation; D007536:Isomerism; D010165:Palladium / Q000737:chemistry; D020005:Propanols / Q000138:chemical synthesis / Q000737:chemistry; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D020005:Propanols; D011724:Pyridazines; D011758:Pyrroles; D010165:Palladium; D003300:Copper; C028255:propargyl alcohol