title: Trends in research on energy balance supported by the National Cancer Institute.
abstract: Over the past decade, the body of research linking energy balance to the incidence, development, progression, and treatment of cancer has grown substantially. No prior NIH portfolio analyses have focused on energy balance within one institute. This portfolio analysis describes the growth of National Cancer Institute (NCI) grant research on energy balance-related conditions and behaviors from 2004 to 2010 following the release of an NCI research priority statement in 2003 on energy balance and cancer-related research. Energy balance grants from fiscal years (FY) 2004 to 2010 were identified using multiple search terms and analyzed between calendar years 2008 and 2010. Study characteristics related to cancer site, design, population, and energy balance area (physical activity, diet, and weight) were abstracted. From FY2004 to FY2010, the NCI awarded 269 energy balance-relevant grants totaling $518 million. In FY2010, 4.2% of NCI's total research project grants budget was allocated to energy balance research, compared to 2.1% in FY2004. The NCI more than doubled support for investigator-initiated research project grants (R01) and increased support for cooperative agreement (U01, U54) and exploratory research (R21) grants. In the portfolio, research examining energy balance areas in combination accounted for 41.6%, and observational and interventional studies were equally represented (38.3% and 37.2%, respectively). Breast cancer was the most commonly studied cancer. Inclusion of minorities rose, and funding specific to cancer survivors more than doubled. From FY2004 to FY2010, NCI's investment in energy balance and related health behavior research showed growth in funding and diversity of mechanisms, topics, and disciplines-growth that reflects new directions in this field.
authors.affiliation: Applied Research Program, Division of Cancer Control and Population Sciences, NIH, Bethesda, Maryland. Electronic address: barbashr@mail.nih.gov.
authors.forename: Rachel
authors.initials: R
authors.lastname: Ballard-Barbash
authors.affiliation: Applied Research Program, Division of Cancer Control and Population Sciences, NIH, Bethesda, Maryland.
authors.forename: Sameer M
authors.initials: SM
authors.lastname: Siddiqi
authors.affiliation: Applied Research Program, Division of Cancer Control and Population Sciences, NIH, Bethesda, Maryland.
authors.forename: David A
authors.initials: DA
authors.lastname: Berrigan
authors.affiliation: Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland.
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Ross
authors.affiliation: Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland.
authors.forename: Linda C
authors.initials: LC
authors.lastname: Nebeling
authors.affiliation: Institute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Dowling
mesh_terms: D035843:Biomedical Research / Q000191:economics / Q000639:trends*; D004734:Energy Metabolism / Q000502:physiology*; D005380:Financing, Government; D015438:Health Behavior; D006801:Humans; D054547:National Cancer Institute (U.S.); D009369:Neoplasms / Q000453:epidemiology / Q000473:pathology*; D012107:Research Design; D012109:Research Support as Topic / Q000639:trends; D014481:United States