title: Chiral magnesium(II) binaphtholates as cooperative Brønsted/Lewis acid-base catalysts for the highly enantioselective addition of phosphorus nucleophiles to α,β-unsaturated esters and ketones.
abstract: A little cooperation goes a long way: The cooperative Brønsted/Lewis acid-base supramolecular catalysts formed in situ from simple chiral magnesium(II) binaphtholate aqua complexes promoted the highly enantioselective 1,4-hydrophosphinylation of α,β-unsaturated esters with diaryl phosphine oxides and 1,2-hydrophosphonylation of α,β-unsaturated ketones with dialkyl phosphites (see scheme).
authors.affiliation: Graduate School of Engineering, Nagoya University, Japan Science and Technology Agency (JST), CREST, Furo-cho, Chikusa, Nagoya 464-8603, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hatano
authors.forename: Takahiro
authors.initials: T
authors.lastname: Horibe
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ishihara
mesh_terms: D002384:Catalysis; D002413:Cations, Divalent / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry; D058115:Lewis Bases / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002413:Cations, Divalent; D004952:Esters; D007659:Ketones; D058116:Lewis Acids; D058115:Lewis Bases; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D008274:Magnesium