title: Enantioselective synthesis of 3,4-dihydropyran derivatives via a Michael addition reaction catalysed by chiral pybox-diph-Zn(II) complex.
abstract: An enantioselective Michael addition of cyclic 1,3-dicarbonyls to 2-enoylpyridine N-oxides catalyzed by a chiral pybox-diph-Zn(II) complex has been developed. The corresponding Michael adducts have been obtained in high yields with up to >99% ee. The Michael adduct has been transformed to biologically active 2,4-disubstituted hexahydroquinoline. A plausible transition-state model has been proposed to explain the stereochemical outcome of the reaction.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, UP - 208 016, India.
authors.forename: Sumit K
authors.initials: SK
authors.lastname: Ray
authors.forename: Subhrajit
authors.initials: S
authors.lastname: Rout
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh