title: Induction of S100B gene expression in long-term potentiation in the hippocampal CA1 field depends on activity of NMDA receptors.
abstract: The effects of NMDA receptor blocker MK-801 on the increase in S100B protein mRNA content induced by long-term posttetanic potentiation in the hippocampal sections were studied. The level of S100B mRNA after 30-min tetanization in the presence of 10 μM MK-801 constituted 132% of the basal level, which was significantly (226%) lower than the control level. Hence, gene expression, induced by long-term posttetanic potentiation, in the glial cells (similarly as in the neurons) depended significantly on NMDA receptors.
authors.affiliation: Designing and Technological Institute of Computer Engineering, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: P D
authors.initials: PD
authors.lastname: Lisachev
authors.forename: V O
authors.initials: VO
authors.lastname: Pustylnyak
authors.forename: M B
authors.initials: MB
authors.lastname: Shtark
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000378:metabolism*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D009414:Nerve Growth Factors; D016194:Receptors, N-Methyl-D-Aspartate; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579158:S100b protein, rat; D016291:Dizocilpine Maleate