title: Partial volume correction using structural-functional synergistic resolution recovery: comparison with geometric transfer matrix method.
abstract: We validated the use of a novel image-based method for partial volume correction (PVC), structural-functional synergistic resolution recovery (SFS-RR) for the accurate quantification of dopamine synthesis capacity measured using [(18)F]DOPA positron emission tomography. The bias and reliability of SFS-RR were compared with the geometric transfer matrix (GTM) method. Both methodologies were applied to the parametric maps of [(18)F]DOPA utilization rates (ki(cer)). Validation was first performed by measuring repeatability on test-retest scans. The precision of the methodologies instead was quantified using simulated [(18)F]DOPA images. The sensitivity to the misspecification of the full-width-half-maximum (FWHM) of the scanner point-spread-function on both approaches was also assessed. In the in-vivo data, the ki(cer) was significantly increased by application of both PVC procedures while the reliability remained high (intraclass correlation coefficients >0.85). The variability was not significantly affected by either PVC approach (<10% variability in both cases). The corrected ki(cer) was significantly influenced by the FWHM applied in both the acquired and simulated data. This study shows that SFS-RR can effectively correct for partial volume effects to a comparable degree to GTM but with the added advantage that it enables voxelwise analyses, and that the FWHM used can affect the PVC result indicating the importance of accurately calibrating the FWHM used in the recovery model.
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul 110-744, Korea. euitae.kim@gmail.com
authors.forename: Euitae
authors.initials: E
authors.lastname: Kim
authors.forename: Miho
authors.initials: M
authors.lastname: Shidahara
authors.forename: Charalampos
authors.initials: C
authors.lastname: Tsoumpas
authors.forename: Colm J
authors.initials: CJ
authors.lastname: McGinnity
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon
authors.forename: Oliver D
authors.initials: OD
authors.lastname: Howes
authors.forename: Federico E
authors.initials: FE
authors.lastname: Turkheimer
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D055815:Young Adult
chemical_list: C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D004298:Dopamine