title: Viral counterattack against the host innate immune system.
abstract: Paramyxoviruses evade antiviral immune response using a small nonstructural protein, V, which binds to the host dsRNA sensor MDA5 and prevents it from activating the interferon signaling pathway. A recent crystal structure of the V protein in complex with MDA5, published in Science, revealed that V disrupts the structure of MDA5 and is integrated into the MDA5 protein fold, providing an intriguing new example of viral mimicry as a countermeasure against the host immune system.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Sun
authors.initials: S
authors.lastname: Hur
mesh_terms: D000818:Animals; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D000072640:Interferon-Induced Helicase, IFIH1; D007372:Interferons / Q000276:immunology / Q000378:metabolism; D018098:Paramyxovirinae / Q000276:immunology*; D017510:Protein Folding; D012330:RNA, Double-Stranded / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D014764:Viral Proteins / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D012330:RNA, Double-Stranded; C502891:V protein, Paramyxovirus; D014764:Viral Proteins; D007372:Interferons; C452815:IFIH1 protein, human; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1