title: The patients with clinically isolated syndrome and relapsing remitting multiple sclerosis show different levels of advanced protein oxidation products and total thiol content in plasma and CSF.
abstract: Advanced oxidation protein products (AOPP) and total thiol (SH) groups levels in plasma and CSF were studied in a cohort of 50 clinically isolated syndrome (CIS) and 57 relapsing remittent multiple sclerosis (RRMS) patients related to 20 control group (CG) patients' values. The obtained results were compared regarding patients demographic, biochemical, clinical (EDSS) and MRI features (total T2 weighted lesions number and Gd enhancement lesion volume). Plasma and CSF AOPP levels in CIS and RRMS patients were higher than those in CG, while SH groups showed lower values compared to CG (p<0.05). Both parameters were higher in CIS than in RRMS patients (p<0.05). Related to EDSS median range, all patients were divided into those with slight or mild and those with severe clinical presentation. AOPP and SH group changes were more pronounced in both, CIS and RRMS patients with higher, compared to those with lower EDSS (p<0.05). AOPP, SH group levels and EDSS positive correlations were observed in both study groups (p<0.01). Both parameters showed the same approach regarding the median range of total T2 weighted lesions and Gd enhancement lesion volume mean values (p<0.05), but no correlation was found between AOPP and SH levels and these patients radiological characteristics (p>0.01). The data support the fact that oxidative stress is always involved in CIS and RRMS pathophysiology, but not always as a disease determinant dependent on its intensity, which might be important for new therapeutic strategies based on antioxidant approach in those patients.
authors.affiliation: Clinic of Neurology, Clinical Center Nis, Bul. Dr Zorana Djindjica 48, 18000 Nis, Serbia. srljub@gmail.com
authors.forename: Srdjan
authors.initials: S
authors.lastname: Ljubisavljevic
authors.forename: Ivana
authors.initials: I
authors.lastname: Stojanovic
authors.forename: Slobodan
authors.initials: S
authors.lastname: Vojinovic
authors.forename: Dragan
authors.initials: D
authors.lastname: Stojanov
authors.forename: Svetlana
authors.initials: S
authors.lastname: Stojanovic
authors.forename: Tatjana
authors.initials: T
authors.lastname: Cvetkovic
authors.forename: Dejan
authors.initials: D
authors.lastname: Savic
authors.forename: Dusica
authors.initials: D
authors.lastname: Pavlovic
mesh_terms: D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood* / Q000134:cerebrospinal fluid*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000134:cerebrospinal fluid*; D019636:Neurodegenerative Diseases / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000097:blood* / Q000134:cerebrospinal fluid*; D013577:Syndrome; D055815:Young Adult
chemical_list: D062107:Advanced Oxidation Protein Products; D013438:Sulfhydryl Compounds