title: [Comparative study on anti-inflammatory and antipyretic effects between Dao-di herb and non Dao-di herb of Huangqin].
abstract: OBJECTIVE
  To do some comparative study on anti-inflammatory and antipyretic effects between the Dao-di herb and non Dao-di herb of Huangqin (the roots of Scutellaria baicalensis) and provide thinking and evidence for study on geoherbalism and clinical usage of Huangqin.
  
  
  METHODS
  The anti-inflammatory action was assessed by auricular swelling induced by dimethylbenzene in mice and the antipyretic action was monitored by dried yeast-induced mice fever.
  
  
  RESULTS
  All samples of both Dao-di and non Dao-di herbs of Huangqin showed antipyretic effect. The Dao-di Huangqin samples showed antipyretic effect between 61% to 53% , whereas the non Dao-di Huangqin samples between 53% to 43%. Six Dao-di Huangqin samples showed better antipyretic effect than four non Dao-di Huangqin samples. All samples of both Dao-di and non Dao-di Huangqin showed anti-inflammatory effect. Dao-di Huangqin showed anti-inflammatory effect between 73% to 54%, whereas non dao-di Huangqin between 53% to 34%. Six Dao-di Huangqin showed better anti-inflammatory effect than four non Dao-di Huangqin. In totality, results from analysis of geoherbalism showed that geoherbal production areas of Huangqin had better effect than that of the non geoherbal production areas in anti-inflammatory and antipyretic effects.
  
  
  CONCLUSIONS
  Both the Dao-di and non Dao-di Huangqin have effects of anti-inflammatory and antipyretic to a certain extent, but the efficacy of the Dao-di Huangqin surpass the non Dao-di Huangqin.
authors.affiliation: Department of Integrated Chinese Traditional with Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
authors.forename: Zai-Wang
authors.initials: ZW
authors.lastname: Wu
authors.forename: Zhe-Ming
authors.initials: ZM
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Lu
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Rui-Qin
authors.initials: RQ
authors.lastname: Qian
authors.forename: Ming-Ying
authors.initials: MY
authors.lastname: Shang
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.forename: Shao-Qing
authors.initials: SQ
authors.lastname: Cai
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D058633:Antipyretics / Q000008:administration & dosage*; D002681:China; D004340:Drug Contamination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice; D031364:Scutellaria baicalensis / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D004365:Drugs, Chinese Herbal