title: Development of novel benzotriazines for drug discovery.
abstract: BACKGROUND
  The synthesis of novel benzotriazine heterocycles was developed independently around the same time by Bischler, Bamberger and Arndt. Over the years, different groups have reported the synthesis of benzotriazine based compounds.
  
  
  OBJECTIVE
  This literature review gives an update on recent benzotriazine compounds and their applications.
  
  
  CONCLUSIONS
  The benzotriazine core has been used in various drug discovery projects including anticancer, anti-inflammatory and antimalarial programs. Recently, the benzotriazine core was used to develop selective kinase inhibitors targeting SRC, VEGFr2, BCR-ABL and BCR-ABL-T315I. Two benzotriazine based compounds, tirapazamine for the treatment of cancer and TG100801 for the treatment of age-related macular degeneration, have entered clinical trials.
authors.affiliation: TargeGen, Inc., 9380 Judicial Drive, CA 92121, San Diego, USA +1 858 678 0760 ; +1 858 678 0762 ; Noronha@targegen.com.
authors.forename: Moorthy Ss
authors.initials: MS
authors.lastname: Palanki
authors.forename: Jianguo
authors.initials: J
authors.lastname: Cao
authors.forename: Chun P
authors.initials: CP
authors.lastname: Chow
authors.forename: Elena
authors.initials: E
authors.lastname: Dneprovskaia
authors.forename: Chi Ching
authors.initials: CC
authors.lastname: Mak
authors.forename: Andrew
authors.initials: A
authors.lastname: McPherson
authors.forename: Ved P
authors.initials: VP
authors.lastname: Pathak
authors.forename: Joel
authors.initials: J
authors.lastname: Renick
authors.forename: Richard
authors.initials: R
authors.lastname: Soll
authors.forename: Binqi
authors.initials: B
authors.lastname: Zeng
authors.forename: Glenn
authors.initials: G
authors.lastname: Noronha