title: Contact sensitization to modern wound dressings in 70 patients with chronic leg ulcers.
abstract: BACKGROUND
  Patients with chronic leg ulcers typically experience contact allergy to topical treatments. Although declared as hypoallergenic, modern wound dressings have caused several reported cases of contact allergy.
  
  
  OBJECTIVE
  The aim of the study was to evaluate any allergenic potential of modern wound dressings in patients with leg ulcers.
  
  
  METHODS
  Seventy-one patients were included in our prospective observation. Patch tests were performed with a selection of 10 modern wound dressings and with selected allergens according to series of the German Contact Dermatitis Research Group (DKG).
  
  
  RESULTS
  Of 70 patients eligible for evaluation, 12 (17%) were positive for the hydrogel NuGel, followed by the hydrocolloid NuDerm (n = 7/70, 10%) and the ionic silver-containing wound dressing Aquacel Ag and the gauze Adaptic (both n = 4/70, 5%). Patients with recalcitrant ulcers of prolonged duration showed a significant higher number of epicutaneous sensitizations to wound dressings than patients with shorter ulcer duration.
  
  
  CONCLUSIONS
  The allergenic potential of modern wound dressings should not be underestimated. There is need for precise declaration of all ingredients.
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig A.ö.R., Leipzig, Germany. regina.renner@uk-erlangen.de
authors.forename: Regina
authors.initials: R
authors.lastname: Renner
authors.forename: Jan C
authors.initials: JC
authors.lastname: Simon
authors.forename: Regina
authors.initials: R
authors.lastname: Treudler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000485:Allergens / Q000009:adverse effects*; D001458:Bandages / Q000009:adverse effects*; D002266:Carboxymethylcellulose Sodium / Q000009:adverse effects; D003102:Colloids / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods; D011446:Prospective Studies; D018030:Silver Compounds / Q000009:adverse effects; D014945:Wound Healing
chemical_list: D000485:Allergens; D003102:Colloids; D018030:Silver Compounds; D002266:Carboxymethylcellulose Sodium