title: Clinical significance of yes-associated protein overexpression in cervical carcinoma: the differential effects based on histotypes.
abstract: OBJECTIVE
  The objective of this study was to explore the prognostic values of Yes-associated protein (YAP) expression in cervical carcinoma.
  
  
  METHODS
  We compared the YAP expression of 120 samples from squamous cell carcinomas (SCCs) and 42 samples from adenocarcinomas with 22 normal cervical specimens by immunohistochemistry. The expressions of cytoplasmic and nuclear YAP were analyzed separately.
  
  
  RESULTS
  Yes-associated protein expression in tumors is significantly higher than the level in normal tissues. In SCCs, cytoplasmic YAP expression is associated with histologic grading, lymph node metastasis, and recurrence. Nuclear expression of YAP is absent in SCC. In adenocarcinomas, cytoplasmic YAP overexpression is associated with histologic grading, and nuclear overexpression is associated with shorter overall survival and disease-free survival.
  
  
  CONCLUSIONS
  Our results indicate the oncogenic potential of YAP in cervical cancer and its distinct functions in SCC and adenocarcinoma.
authors.affiliation: Department of Gynecology, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Liu
authors.forename: Yunduo
authors.initials: Y
authors.lastname: Liu
authors.forename: Hongyu
authors.initials: H
authors.lastname: Gao
authors.forename: Fanling
authors.initials: F
authors.lastname: Meng
authors.forename: Shanshan
authors.initials: S
authors.lastname: Yang
authors.forename: Ge
authors.initials: G
authors.lastname: Lou
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis* / Q000235:genetics* / Q000378:metabolism; D000230:Adenocarcinoma / Q000378:metabolism*; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D002584:Cervix Uteri / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D010750:Phosphoproteins / Q000096:biosynthesis* / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human