title: Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector.
abstract: Direct monitoring of singlet oxygen (¹O₂) luminescence is a particularly challenging infrared photodetection problem. ¹O₂, an excited state of the oxygen molecule, is a crucial intermediate in many biological processes. We employ a low noise superconducting nanowire single-photon detector to record ¹O₂ luminescence at 1270 nm wavelength from a model photosensitizer (Rose Bengal) in solution. Narrow band spectral filtering and chemical quenching is used to verify the ¹O₂ signal, and lifetime evolution with the addition of protein is studied. Furthermore, we demonstrate the detection of ¹O₂ luminescence through a single optical fiber, a marked advance for dose monitoring in clinical treatments such as photodynamic therapy.
authors.affiliation: Scottish Universities Physics Alliance and School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK.
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Gemmell
authors.forename: Aongus
authors.initials: A
authors.lastname: McCarthy
authors.forename: Baochang
authors.initials: B
authors.lastname: Liu
authors.forename: Michael G
authors.initials: MG
authors.lastname: Tanner
authors.forename: Sander D
authors.initials: SD
authors.lastname: Dorenbos
authors.forename: Valery
authors.initials: V
authors.lastname: Zwiller
authors.forename: Michael S
authors.initials: MS
authors.lastname: Patterson
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Buller
authors.forename: Brian C
authors.initials: BC
authors.lastname: Wilson
authors.forename: Robert H
authors.initials: RH
authors.lastname: Hadfield
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D004553:Electric Conductivity; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D008027:Light; D008163:Luminescent Measurements / Q000295:instrumentation*; D043942:Nanotubes / Q000737:chemistry / Q000528:radiation effects*; D010783:Photometry / Q000295:instrumentation*; D017785:Photons; D026082:Singlet Oxygen / Q000032:analysis*
chemical_list: D026082:Singlet Oxygen