title: CancerDR: cancer drug resistance database.
abstract: Cancer therapies are limited by the development of drug resistance, and mutations in drug targets is one of the main reasons for developing acquired resistance. The adequate knowledge of these mutations in drug targets would help to design effective personalized therapies. Keeping this in mind, we have developed a database "CancerDR", which provides information of 148 anti-cancer drugs, and their pharmacological profiling across 952 cancer cell lines. CancerDR provides comprehensive information about each drug target that includes; (i) sequence of natural variants, (ii) mutations, (iii) tertiary structure, and (iv) alignment profile of mutants/variants. A number of web-based tools have been integrated in CancerDR. This database will be very useful for identification of genetic alterations in genes encoding drug targets, and in turn the residues responsible for drug resistance. CancerDR allows user to identify promiscuous drug molecules that can kill wide range of cancer cells. CancerDR is freely accessible at http://crdd.osdd.net/raghava/cancerdr/
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Kumar
authors.forename: Kumardeep
authors.initials: K
authors.lastname: Chaudhary
authors.forename: Sudheer
authors.initials: S
authors.lastname: Gupta
authors.forename: Harinder
authors.initials: H
authors.lastname: Singh
authors.forename: Shailesh
authors.initials: S
authors.lastname: Kumar
authors.forename: Ankur
authors.initials: A
authors.lastname: Gautam
authors.forename: Pallavi
authors.initials: P
authors.lastname: Kapoor
authors.forename: Gajendra P S
authors.initials: GP
authors.lastname: Raghava
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D016208:Databases, Factual; D019008:Drug Resistance, Neoplasm; D006801:Humans; D020407:Internet; D009154:Mutation; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D014584:User-Computer Interface
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins