title: [Association between adipokines and the development of osteopenic syndrome in end-stage lung disease].
abstract: OBJECTIVE
  To study of an association between adipokines, nutritional status, and bone mineral density (BMD) in end-stage lung disease (ESLD).
  
  
  METHODS
  Forty-seven patients aged 26 to 62 years with ESLD were examined. BMD in the lumbar spine (L(II)-L(IV)) and left femoral neck (FN) was estimated using dual-energy X-ray absorptiometry (DXA). The serum levels of adipokines (leptin, adiponectin resistin, tumor necrosis factor-alpha (TNF-alpha), and its receptors sTNFR I, II) were determined. A control group consisted of 45 healthy volunteers matched for age and gender.
  
  
  RESULTS
  Osteopenic syndrome (T-score < -1 SD) was recorded in 43 (91%) of the 47 examined patients with ESLD. In lung diseases, the concentrations of adiponectin, resistin, TNF-alpha, and its receptors were higher and the level of leptin was lower than in the control group. There was a positive correlation between the content of leptin (r = 0.64, p = 0.0002; r = 0.52, p = 0.009) and a negative correlation between adiponectin (r = -0.54, p = 0.009; r = -0.47, p = 0.003), TNF-alpha (r = -0.43, p = 0.03; r = -0.41, p = 0.04), and BMD in FN and FN L(II)-L(IV). Correlation analysis showed a positive correlation between the level of resistin (r = 0.57; p = 0.004), sTNFR I (r = 0.42; p = 0.03), sTNFR II (r = 0.44; p = 0.04), and BMD in L(II)-L(IV) only. The serum leptin level was positively correlated with body mass index (BMI) (r = 0.82; p < 0.0001) and total fat mass (TFM) (r = 0.84; p < 0.0001). On the contrary, the level of adiponectin was inversely correlated with BMI (r = -0.68; p < 0.001), serum resistin concentration (r = -0.57; p = 0.004), sTNFR I (r = -0.58; p = 0.007), and sTNFR II (r = -0.53; p = 0.006). It was stated that there was a strong inverse correction between the levels of leptin and adiponectin (r = -0.67; p = 0.0008).
  
  
  CONCLUSIONS
  The found associations between adipokines and BMD may suggest that these markers are implicated in the pathogenesis of osteopenic syndrome in ESLD.
authors.forename: E A
authors.initials: EA
authors.lastname: Kochetkova
authors.forename: L G
authors.initials: LG
authors.lastname: Ugaĭ
authors.forename: K A
authors.initials: KA
authors.lastname: Buria
authors.forename: V A
authors.initials: VA
authors.lastname: Nevzorova
authors.forename: J
authors.initials: J
authors.lastname: Massard
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D054392:Adipokines / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D012129:Respiratory Function Tests / Q000379:methods; D012720:Severity of Illness Index; D013223:Statistics as Topic; D048069:Tumor Necrosis Factors / Q000097:blood*
chemical_list: D054392:Adipokines; D015415:Biomarkers; D018124:Receptors, Tumor Necrosis Factor; D048069:Tumor Necrosis Factors