title: MicroRNA-mediated control of macrophages and its implications for cancer.
abstract: Deregulation of microRNAs (miRNAs) can drive oncogenesis, tumor progression, and metastasis by acting cell-autonomously in cancer cells. However, solid tumors are also infiltrated by large amounts of non-neoplastic stromal cells, including macrophages, which express several active miRNAs. Tumor-associated macrophages (TAMs) enhance angiogenic, immunosuppressive, invasive, and metastatic programming of neoplastic tissue and reduce host survival. Here, we review the role of miRNAs (including miR-155, miR-146, and miR-511) in the control of macrophage production and activation, and examine whether reprogramming miRNA activity in TAMs and/or their precursors might be effective for controlling tumor progression.
authors.affiliation: The Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.
authors.forename: Mario Leonardo
authors.initials: ML
authors.lastname: Squadrito
authors.forename: Martin
authors.initials: M
authors.lastname: Etzrodt
authors.forename: Michele
authors.initials: M
authors.lastname: De Palma
authors.forename: Mikael J
authors.initials: MJ
authors.lastname: Pittet
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D002454:Cell Differentiation / Q000276:immunology*; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D035683:MicroRNAs / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*
chemical_list: D035683:MicroRNAs