title: [Diagnostic markers of iron deficiency: which should we choose?].
abstract: Iron deficiency is generally investigated when faced with anemia, or with symptoms that could be related to iron deficiency without anemia. This simple disorder is easy to treat, provided that the diagnosis is correct. Several biological tests are available, but their interpretation is oftentimes problematic. Pre-analytical factors can interfere with measurements, normal values can change depending on suppliers, and, above all, results from different markers can be contradictory in some clinical situations. The aim of this article is to evaluate how the evolution of scientific knowledge and clinical trials can contribute to a better understanding and greater reliability in the diagnosis of iron deficiency.
authors.affiliation: Service régional vaudois de transfusion sanguine, Route de la Corniche 2, 1066 Epalinges. sophie.waldvogel@mavietonsang.ch
authors.forename: S
authors.initials: S
authors.lastname: Waldvogel Abramowski
authors.forename: B
authors.initials: B
authors.lastname: Favrat
authors.forename: P
authors.initials: P
authors.lastname: Vaucher
authors.forename: J
authors.initials: J
authors.lastname: Cornuz
authors.forename: J-D
authors.initials: JD
authors.lastname: Tissot
mesh_terms: D000483:Alleles; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000097:blood; D023181:Antimicrobial Cationic Peptides / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002986:Clinical Trials as Topic; D003937:Diagnosis, Differential; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D005293:Ferritins / Q000097:blood*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D064451:Hepcidins; D006801:Humans; D007501:Iron / Q000097:blood*; D009154:Mutation; D010976:Platelet Count; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic; D011990:Receptors, Transferrin / Q000097:blood / Q000235:genetics; D012680:Sensitivity and Specificity; D014131:Trace Elements / Q000097:blood*; D061250:Transferrins / Q000097:blood*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; D006454:Hemoglobins; D064451:Hepcidins; D011990:Receptors, Transferrin; C503640:TFR2 protein, human; D014131:Trace Elements; D061250:Transferrins; D005293:Ferritins; D007501:Iron