title: [Bacterial type I topoisomerases - biological function and potential use as targets for antibiotic treatments].
abstract: The bacterial chromosome is composed of topologically independent domains, whose spatial organization is controlled by enzymes called topoisomerases. Topology maintenance is crucial in many important cellular processes such as replication, transcription and recombination. Moreover, the role of chromosome topology in adaptation of bacteria to environmental changes and, in the case of pathogenic strains, in their virulence was described. In recent years higher numbers of pathogenic strains resistant to antibiotic treatment have been noticed. In this paper we present the current state of knowledge about the structure and cellular functions of bacterial topoisomerases IA. In particular, we discuss the potential use of these enzymes as new targets for antibacterial compounds.
authors.affiliation: Uniwersytet Wrocławski, Wydział Biotechnologii, Wrocław. marcin.szafran@uni.wroc.pl
authors.forename: Marcin
authors.initials: M
authors.lastname: Szafran
authors.forename: Jolanta
authors.initials: J
authors.lastname: Zakrzewska-Czerwińska
authors.forename: Dagmara
authors.initials: D
authors.lastname: Jakimowicz
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000201:enzymology* / Q000472:pathogenicity; D002875:Chromosomes / Q000378:metabolism; D004264:DNA Topoisomerases, Type I / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D015394:Molecular Structure; D014774:Virulence / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004264:DNA Topoisomerases, Type I