title: Exercise and coronary heart disease risk markers in South Asian and European men.
abstract: OBJECTIVE
  South Asians have a higher-than-average risk of CHD. The reasons for this are unclear, but physical inactivity and/or poor responsiveness to exercise may play a role. This study compared the effect of prior exercise on postprandial triacylglycerol (TAG), glucose, insulin, interleukin-6, and soluble intercellular adhesion molecule-1 concentrations in South Asian and European men.
  
  
  METHODS
  Ten healthy South Asian men (i.e., nine Indian men and one Pakistani man) and 10 healthy European men age 20 to 28 yr completed two 2-d trials (exercise and control) in a randomized crossover design. On the afternoon of day 1 of the exercise trial, participants ran on a treadmill for 60 min at approximately 70% of maximal oxygen uptake. Participants rested on day 1 of the control trial. On day 2 of both trials, participants rested and consumed high-fat (57% of energy content) test meals for breakfast (0 h) and lunch (4 h). Fourteen venous blood samples were collected from a cannula between 0 and 9 h for metabolic measurements.
  
  
  RESULTS
  Three-way ANOVA identified higher (P < 0.05) postprandial TAG and insulin concentrations in South Asian versus European men. Exercise lowered postprandial TAG and interleukin-6 and elevated soluble intercellular adhesion molecule-1 concentrations. An interaction effect indicated a greater decrease (22% vs 10%) in TAG area under the concentration versus time curve after exercise in South Asian than in European men.
  
  
  CONCLUSIONS
  Postprandial TAG and insulin responses to high-fat meals were elevated in these South Asian men, but acute exercise was equally, if not more, effective for reducing postprandial lipemia in South Asian than in European men.
authors.affiliation: School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, England, United Kingdom.
authors.forename: Saravana Pillai
authors.initials: SP
authors.lastname: Arjunan
authors.forename: Nicolette Claire
authors.initials: NC
authors.lastname: Bishop
authors.forename: Alvaro
authors.initials: A
authors.lastname: Reischak-Oliveira
authors.forename: David John
authors.initials: DJ
authors.lastname: Stensel
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000208:ethnology* / Q000209:etiology / Q000517:prevention & control; D018592:Cross-Over Studies; D059305:Diet, High-Fat; D005080:Exercise Test; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000208:ethnology / Q000517:prevention & control*; D007194:India / Q000208:ethnology; D008297:Male; D062407:Meals; D010154:Pakistan / Q000208:ethnology; D019518:Postprandial Period / Q000502:physiology; D012307:Risk Factors; D012420:Running / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D044465:White People
chemical_list: D015415:Biomarkers; D014280:Triglycerides