title: Development of CD27+ marginal zone B cells requires GALT.
abstract: In species other than mouse, little is known about the origin and development of marginal zone (MZ) B cells. Using cross-reactive antibodies, we identified and characterized splenic MZ B cells in rabbits as CD27(+) CD23(-). In rabbits in which organized gut-associated lymphoid tissue (GALT) was surgically removed at birth, we found only CD23(+) follicular (FO) B cells and almost no CD27(+) MZ B cells in the spleen, indicating that GALT is required for the development of splenic MZ B cells. These findings lead us to suggest that commensal microbiota contribute to the development of MZ B cells.
authors.affiliation: Department of Microbiology and Immunology, Loyola University, Chicago, IL, USA.
authors.forename: Venkata A
authors.initials: VA
authors.lastname: Yeramilli
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Knight
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D007422:Intestines / Q000276:immunology*; D008221:Lymphoid Tissue / Q000601:surgery; D054892:Metagenome / Q000276:immunology; D051379:Mice; D011817:Rabbits; D017455:Receptors, IgE / Q000378:metabolism; D013154:Spleen / Q000276:immunology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000378:metabolism
chemical_list: D017455:Receptors, IgE; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7