title: The interleukin-1 gene cluster polymorphisms are associated with Takayasu's arteritis in Mexican patients.
abstract: Takayasu's arteritis (TA) is a chronic inflammatory arteritis of unknown etiology involving mainly the aorta and its major branches. The interleukin (IL) 1β and IL-1 receptor antagonist have been playing an important role as regulators of inflammation. We investigated whether the polymorphisms at the IL-1B and IL-1RN gene cluster were associated with the genetic susceptibility to develop TA. We analyzed the IL-1B, IL-1F10.3, and IL-1RN polymorphisms in a sample of 58 TA patients, and 248 clinically healthy unrelated Mexican individuals by 5' exonuclease TaqMan polymerase chain reaction. Polymorphic haplotypes were constructed after linkage disequilibrium analysis. We found increased frequencies of different polymorphisms (C allele and TC genotype of IL-1F10.3; TT genotype of IL-1RN.4; C allele and TC genotype of IL-1RN6.1; G allele of IL-1RN6.2 and haplotypes "1T" and "1C" of IL-RN VNTR and IL-1RN6.1) in the group of TA when compared to healthy controls. On the other hand, decreased frequency of IL-1-511 TC genotype was found in the TA group compared to controls. IL-1B and IL-1RN gene polymorphisms could be involved in the risk of developing TA in the Mexican population. These associations were independent of the affected vessels.
authors.affiliation: Department of Immunology, National Cardiology Institute Ignacio Chávez, Mexico City, Mexico.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Soto López
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gamboa Ávila
authors.forename: Erick
authors.initials: E
authors.lastname: Hernández
authors.forename: Claudia
authors.initials: C
authors.lastname: Huesca-Gómez
authors.forename: Vicente
authors.initials: V
authors.lastname: Castrejón-Téllez
authors.forename: Oscar
authors.initials: O
authors.lastname: Pérez-Méndez
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Reyes
authors.forename: José M
authors.initials: JM
authors.lastname: Fragoso-Lona
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.forename: David
authors.initials: D
authors.lastname: Cruz-Robles
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D007375:Interleukin-1 / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008800:Mexico; D008875:Middle Aged; D005810:Multigene Family; D011110:Polymorphism, Genetic; D012306:Risk; D013625:Takayasu Arteritis / Q000235:genetics* / Q000276:immunology*; D055815:Young Adult
chemical_list: C430241:IL1F10 protein, human; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D053583:Interleukin-1beta