title: Antioxidant properties of Pelargonium graveolens L'Her essential oil on the reproductive damage induced by deltamethrin in mice as compared to alpha-tocopherol.
abstract: BACKGROUND
  Exposure to the pyrethroid pesticide deltamethrin has been demonstrated to exert a wide range of effects on non-targeted organisms. The beneficial effects of geranuim essential oil (EO) as an antioxidant has been assessed in deltamethrin (DL) orally administered mice by studying whether the reprotoxicity caused by deltamethrin can be effectively combated with the geranium oil and the effects were compared to vitamin E, as the standard reference drug.
  
  
  RESULTS
  Sixty male albino mice were divided into six equal groups: a control group, a group of mice was given deltamethrin (5 mg/kg b.w.), two groups were administered deltamethrin after having given geranium essential oil (67 mg/kg b.w.) or vitamin E (Vit E) (100 mg/kg b.w.), and two groups received only EO of geranium or Vit E. When compared to control, a dose of deltamethrin 5 mg/kg/day causes a decrease in the epididymal sperm count motility and viability and an increase in the number of abnormal morphology in spermatozoa. DL-exposed mice showed a significant increase of lipid peroxidation (LPP) in the testis compared to control animals.
  
  
  CONCLUSIONS
  Essential oil of geranium prevented testicular oxidative damage explored by reduced LPP and improved total sperm motility, viability and morphology in mice spermatozoa. Our study showed a positive influence of geranium essential oil in the animal male reproductive system similar than that of Vit E.
authors.forename: Ahlem
authors.initials: A
authors.lastname: Ben Slima
authors.forename: Manel Ben
authors.initials: MB
authors.lastname: Ali
authors.forename: Mohamed
authors.initials: M
authors.lastname: Barkallah
authors.forename: Al Ibrahim
authors.initials: AI
authors.lastname: Traore
authors.forename: Tahia
authors.initials: T
authors.lastname: Boudawara
authors.forename: Noureddine
authors.initials: N
authors.lastname: Allouche
authors.forename: Radhouane
authors.initials: R
authors.lastname: Gdoura
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D009570:Nitriles / Q000633:toxicity*; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D031316:Pelargonium / Q000737:chemistry*; D011722:Pyrethrins / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013737:Testis / Q000187:drug effects; D024502:alpha-Tocopherol / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D007306:Insecticides; D009570:Nitriles; D009822:Oils, Volatile; D011722:Pyrethrins; C017180:decamethrin; D024502:alpha-Tocopherol