title: Hypoxia-driven immunosuppression contributes to the pre-metastatic niche.
abstract: Primary tumor cells create favorable microenvironments in secondary organs, termed pre-metastatic niches, that promote the formation of metastases. Using immune competent syngenic breast cancer mouse models, we have recently demonstrated that factors secreted by hypoxic tumor cells condition pre-metastatic niches by recruiting CD11b+/Ly6Cmed/Ly6G+myeloid cells and suppressing natural killer cell functions.
authors.affiliation: Cancer Genomics and Genetics Laboratory; Peter MacCallum Cancer Centre; East Melbourne, VIC Australia ; Department of Pathology and Sir Peter MacCallum Department of Oncology; The University of Melbourne; Parkville; VIC Australia.
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Sceneay
authors.forename: Belinda S
authors.initials: BS
authors.lastname: Parker
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Smyth
authors.forename: Andreas
authors.initials: A
authors.lastname: Möller
keywords: MDSC; NK cells; bone marrow-derived cells; breast cancer; hypoxia; immunosuppression; pre-metastatic niche