title: Concurrent treatment of chronic psoriasis and asthma with ustekinumab.
abstract: A 56-year-old woman with a 40-year history of guttate flares of psoriasis associated with stress and infection as well as chronic asthma was treated with subcutaneous injections of ustekinumab, repeated after 1 month and then every 3 months. Her psoriasis completely resolved, and her capacity for exercise was markedly increased and asthma maintenance medications were no longer needed. Ustekinumab is a human monoclonal antibody that binds the p40 subunit of IL-12 and IL-23 to limit the progression of the Th1 and Th17 inflammatory immune responses that maintain many autoimmune and inflammatory diseases. Th17-related responses drive inflammation during late stages of chronic asthma and can also be blocked by ustekinumab. Blocking the underlying cytokine-mediated inflammatory responses for psoriasis with ustekinumab can also treat other chronic inflammatory diseases.
authors.affiliation: Departments of Internal Medicine, Dermatology, Northeast Ohio Medical University , Rootstown, OH , USA.
authors.forename: Ajay
authors.initials: A
authors.lastname: Amarnani
authors.forename: Ken S
authors.initials: KS
authors.lastname: Rosenthal
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Mercado
authors.forename: Robert T
authors.initials: RT
authors.lastname: Brodell
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000378:metabolism / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy; D007279:Injections, Subcutaneous; D018664:Interleukin-12 / Q000378:metabolism; D053759:Interleukin-23 / Q000378:metabolism; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D000069549:Ustekinumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007166:Immunosuppressive Agents; D053759:Interleukin-23; D018664:Interleukin-12; D000069549:Ustekinumab