title: Autologous bone marrow mononuclear cells transplant in patients with critical leg ischemia: preliminary clinical results.
abstract: OBJECTIVE
  Stem cell transplant can induce vasculogenesis and improve the blood supply to an ischemic region, offering hope for chronic lower extremity ischemic diseases. Bone marrow mononuclear cells are one of the sources for stem cell transplants. We sought to observe the safety and efficacy of autologous bone marrow mononuclear cells transplant for treating critical limb ischemia.
  
  
  METHODS
  Eligible patients were randomized 1:1 to receive placebo (0.9% NaCl) or 1 × 107 piece/mL bone marrow mononuclear cell transplant. For 6 months, patients' skin ulcers, ankle-brachial index, and rest pain were examined and recorded before and after treatment.
  
  
  RESULTS
  Six months after the bone marrow mononuclear cells transplant, clinical symptoms like rest pain and skin ulcers gradually abated (P < .05). Ankle-brachial index also increased after the transplant (P < .01).
  
  
  CONCLUSIONS
  Autologous bone marrow mononuclear cells transplant for treatment of patients with chronic limb ischemia is safe, effective, and feasible.
authors.affiliation: Department of Cardiology Provincial Hospital affiliated to Shandong University, Shandong Province, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Zhou
authors.forename: Xing
authors.initials: X
authors.lastname: Jin
authors.forename: Mo
authors.initials: M
authors.lastname: Wang
authors.forename: Shiyi
authors.initials: S
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D002681:China; D002908:Chronic Disease; D016638:Critical Illness; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D007871:Leg Ulcer / Q000175:diagnosis / Q000209:etiology; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects; D008875:Middle Aged; D010146:Pain / Q000175:diagnosis / Q000209:etiology; D010147:Pain Measurement; D020127:Recovery of Function; D016037:Single-Blind Method; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014945:Wound Healing