title: The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis.
abstract: Chemokine receptors (CCRs) play important roles in the pathogenesis of immune-mediated diseases, as well as in normal immune response. We examined the role of CCR6 and CCR4 in experimental autoimmune encephalomyelitis (EAE) by using CCR6(-/-)CCR4(-/-) double knockout (DKO) and single knockout mice. DKO mice developed less severe EAE and presented repressed recall response in the induction phase, especially in the activity of T helper 17 (Th17) cells. CCR6 expression in central nervous system (CNS)-infiltrated cells was diminished in DKO. Our results suggest that CCR6 and CCR4 were involved in a more rapid progression of EAE and that their regulation might be a therapeutic target of human inflammatory demyelinating diseases.
authors.affiliation: Division of Neurology, Department of Internal Medicine 3, National Defense Medical College, Tokorozawa, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Moriguchi
authors.forename: Katsuichi
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Noriko
authors.initials: N
authors.lastname: Tanaka
authors.forename: Osamu
authors.initials: O
authors.lastname: Yoshie
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
mesh_terms: D000818:Animals; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D054398:Receptors, CCR4 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D054399:Receptors, CCR6 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: C498126:CCR6 protein, mouse; C515355:Ccr4 protein, mouse; D054398:Receptors, CCR4; D054399:Receptors, CCR6