title: Etoricoxib attenuates effect of antihypertensives in a rodent model of DOCA-salt induced hypertension.
abstract: While it is known that non-steroidal anti-inflammatory drugs including selective cyclooxygenase-2 (COX-2) inhibitors influence BP, the exact relationship and underlying mechanisms are still unclear. We investigated the effect of etoricoxib, a selective COX-2 inhibitor on the antihypertensive efficacy of atenolol; beta-blocker, ramipril; angiotensin converting enzyme inhibitor and telmisartan; angiotensin receptor blocker in deoxycorticosterone acetate (DOCA)-salt hypertensive rats, a mineralocorticoid volume expansion model. Etoricoxib attenuated the antihypertensive-induced reduction of systolic (atenolol; P < .001, ramipril; P = .011, telmisartan; P = .003) and mean arterial pressure (atenolol; P < .001, ramipril; P = .032, telmisartan; P = .023). These results demonstrate that COX-2 dependent mechanisms play a significant role in blood pressure regulation, and etoricoxib-induced COX-2 inhibition blunts the therapeutic effect of different classes of antihypertensives in this mineralocorticoid volume expansion model of hypertension.
authors.affiliation: Department of Pharmacology, Maulana Azad Medical College , New Delhi 110002 , India.
authors.forename: Preeta Kaur
authors.initials: PK
authors.lastname: Chugh
authors.forename: Monica
authors.initials: M
authors.lastname: Gupta
authors.forename: Monika
authors.initials: M
authors.lastname: Agarwal
authors.forename: Uma
authors.initials: U
authors.lastname: Tekur
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001262:Atenolol / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology*; D064791:Desoxycorticosterone Acetate; D004195:Disease Models, Animal; D000077613:Etoricoxib; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D008901:Mineralocorticoids / Q000506:poisoning*; D011725:Pyridines / Q000494:pharmacology*; D017257:Ramipril / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000506:poisoning*; D013450:Sulfones / Q000494:pharmacology*; D000077333:Telmisartan
chemical_list: D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001565:Benzoates; D052246:Cyclooxygenase 2 Inhibitors; D008901:Mineralocorticoids; D011725:Pyridines; D013450:Sulfones; D012965:Sodium Chloride; D001262:Atenolol; D064791:Desoxycorticosterone Acetate; D017257:Ramipril; D000077333:Telmisartan; D000077613:Etoricoxib