title: [Giant teratoma of the umbilical cord associated with foetal malformations: a morphological and cytogenetic study].
abstract: We report on an unusually large teratoma of the umbilical cord associated with multiple fetal anomalies. At 18 WG, an umbilical cord tumour was discovered by ultrasonography in a 38 year-old woman. A 2680 g female neonate (46, XX) was delivered at 37 WG by caesarean section. During surgery for exomphalos, a complete bowel malrotation, ischemic jejunal stenoses and bowel duplication were discovered. The tumor (2515 g) was a teratoma supplied by collaterals of the umbilical vein. Proliferative index calculated by flow cytometry was less than 10%. Tumor karyotype revealed several numerical anomalies with no structural abnormalities using multi-FISH analysis. Immunostaining for CEA and AFP were observed in endodermic derivatives of the duplication and associated with transient high levels of AFP in the blood. To our knowledge, it is the first case to be reported in the literature where karyotype, multi-FISH and FCM studies were available.
authors.affiliation: Laboratoire d'anatomie pathologique, pavillon Jacques-Delarue, CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Crahes
authors.forename: Sophie
authors.initials: S
authors.lastname: Patrier
authors.forename: Valentine
authors.initials: V
authors.lastname: Ickowicz
authors.forename: Eléonore
authors.initials: E
authors.lastname: Blondiaux
authors.forename: Frédéric
authors.initials: F
authors.lastname: Elbaz
authors.forename: Alain
authors.initials: A
authors.lastname: Diguet
authors.forename: Annie
authors.initials: A
authors.lastname: Laquerrière
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D013724:Teratoma / Q000150:complications* / Q000473:pathology*; D014470:Umbilical Cord