title: Implications of multipotent mesenchymal stromal cell aging.
abstract: Aging is defined as the progressive and generalized impairment of function, resulting in an increasing vulnerability to environmental challenges and a growing risk of disease and death. The decline in the regenerative capacity of resident stem cells across different tissues is a central mediator of aging. In this paper we review the evidence implicating multipotent mesenchymal stromal cells as being subject to and causes of tissue and organismal aging. We specifically discuss the nuclear changes that occur in the context of Hutchinson-Gilford progeria syndrome, a premature aging syndrome that preferentially affects tissues of mesenchymal origin.
authors.affiliation: Department of Physiology, McGill University, McIntyre Medical Sciences Building, Room 1115, 3655 Promenade Sir William Osler, Montréal, Québec H3G 1Y6, Canada.
authors.forename: Ursula
authors.initials: U
authors.lastname: Stochaj
authors.forename: Mohamed
authors.initials: M
authors.lastname: Kodiha
authors.forename: Dominique
authors.initials: D
authors.lastname: Shum-Tim
authors.forename: Inés
authors.initials: I
authors.lastname: Colmegna
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology; D016922:Cellular Senescence; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D008322:Mammals; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D011371:Progeria / Q000473:pathology