title: Effect of a hypocaloric diet with a commercial formula in weight loss and quality of life in obese patients with chronic osteoarthritis.
abstract: BACKGROUND
  The aim of our study was to evaluate in patients with obesity and chronic osteoarthritis the impact on quality of life and metabolic control of a dietary intervention with a hypocaloric commercial formula.
  
  
  METHODS
  A sample of 55 obese patients with chronic osteoarthritis was enrolled. The study consisted of a 12-week weight reduction program where the participants received an oral diet replaced with 2 bricks of Optisource Plus®.
  
  
  RESULTS
  In order to assess the effect of weight loss on different parameters, patients were divided in two groups by the median of weight loss percentage (9%); group 1 (< 9%) and group 2 (> 9%). In group 2, patients showed an improvement in total SF-36 score (4.0 ± 6.1 points), physical function domain of SF 36 (1.8 ± 3.4 points), role physical domain of SF 36 (0.6 ± 1.6 points) and vitality domain of SF 36 (2.7 ± 4.6 points) improved. Total score of WOMAC test (- 8.2 ± 15.0 points), function domain of WOMAC test (- 6.5 ± 10.6 points) and stiffness domain of WOMAC test (-0.7 ± 2.1 points) improved, too.
  
  
  CONCLUSIONS
  The effect on metabolic response, functionality and quality of life was better in patients with a percentage of weight loss > 9% than patients with a lower weight loss.
authors.affiliation: Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School, Unit of Investigation, University of Valladolid. Valladolid. Spain. dadluis@yahoo.es
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.forename: O
authors.initials: O
authors.lastname: Izaola
authors.forename: M
authors.initials: M
authors.lastname: García Alonso
authors.forename: R
authors.initials: R
authors.lastname: Aller
authors.forename: G
authors.initials: G
authors.lastname: Cabezas
authors.forename: B
authors.initials: B
authors.lastname: de la Fuente
mesh_terms: D000368:Aged; D000886:Anthropometry; D015992:Body Mass Index; D031204:Caloric Restriction / Q000379:methods*; D002908:Chronic Disease; D005247:Feeding Behavior; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000178:diet therapy* / Q000523:psychology*; D010003:Osteoarthritis / Q000150:complications / Q000523:psychology*; D010146:Pain / Q000453:epidemiology; D011788:Quality of Life / Q000523:psychology*; D015431:Weight Loss / Q000502:physiology*