title: A newly identified polysaccharide from Ganoderma atrum attenuates hyperglycemia and hyperlipidemia.
abstract: A polysaccharide from Ganoderma atrum (PSG-1) was purified and characterized, and its hypoglycemic and hypolipidemic effects were investigated in high fat diet- and streptozotocin-induced type 2 diabetic rats. Oral administration of PSG-1 at 200 or 400 mg/kg body weight significantly reduced fasting blood glucose and serum insulin levels. PSG-1 significantly decreased the levels of serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, free fatty acid and insulin resistance, and increased high-density lipoprotein cholesterol level and insulin sensitivity. In addition, PSG-1 inhibited the expression of pro-apoptotic protein, Bax and increased the expression of anti-apoptotic protein, Bcl-2 in pancreatic cells, suggesting that PSG-1 exerted a protective role in the pancreas of diabetic rats. These results indicated that PSG-1 may have a potential for the treatment of hyperglycemia, hyperlipidemia, hyperinsulinemia and insulin resistance in type 2 diabetes.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
authors.forename: Kexue
authors.initials: K
authors.lastname: Zhu
authors.forename: Shaoping
authors.initials: S
authors.lastname: Nie
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.forename: Suli
authors.initials: S
authors.lastname: Lin
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Xing
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Li
authors.forename: Deming
authors.initials: D
authors.lastname: Gong
authors.forename: Mingyong
authors.initials: M
authors.lastname: Xie
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D062610:Fungal Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D032902:Ganoderma / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy*; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis
chemical_list: C494828:Bax protein, rat; D062610:Fungal Polysaccharides; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D051028:bcl-2-Associated X Protein