title: Increased IL-17A but decreased IL-27 serum levels in patients with multiple sclerosis.
abstract: BACKGROUND
  Effector CD4+ T cell subsets play an important role in Multiple Sclerosis (MS). Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of Type 1 regulatory T cells (Tr1).
  
  
  OBJECTIVE
  To identify the relative levels of IL-27 and IL-17A in MS disease.
  
  
  METHODS
  In a case-control study, venous blood was collected from forty MS patients and forty-three healthy subjects as control group. Serum levels of IL-27 and IL-17A were measured by ELISA method.
  
  
  RESULTS
  A significant difference between serum IL-17A concentration in patients (120.68 ± 209.85 pg/ml) and control group (67.26 ± 117.76 pg/ml, p=0.016) was found. Serum IL-27 levels of the MS patients (159.7 ± 581.4 pg/ml) were significantly lower than control subjects (180.35 ± 507.84 pg/ml, p=0.001).
  
  
  CONCLUSIONS
  Our findings show decreased levels of IL-27 against increasing IL-17A levels in patients group which may suggest a suppressive role of IL-27 on inflammatory process of MS.
authors.affiliation: Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, zbabaloo@tbzmed.ac.ir.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Babaloo
authors.forename: Reza Khajir
authors.initials: RK
authors.lastname: Yeganeh
authors.forename: Mehdi
authors.initials: M
authors.lastname: Farhoodi
authors.forename: Behzad
authors.initials: B
authors.lastname: Baradaran
authors.forename: Mohamadreza
authors.initials: M
authors.lastname: Bonyadi
authors.forename: Leili
authors.initials: L
authors.lastname: Aghebati
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D064094:Interleukin-27 / Q000097:blood*; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D064094:Interleukin-27