title: Anti-parkinsonism, hypoglycemic and anti-microbial activities of new poly fused ring heterocyclic candidates.
abstract: A new series of poly fused pyrazolothienopyrimidine derivatives (2-14) were synthesized and their anti-parkinsonism, hypoglycemic and anti-microbial activities were evaluated. Some of the newly synthesized compounds exhibited better pharmacological and biological activities than the reference controls with low concentrations. The structures of newly synthesized compounds were confirmed by chemical, elemental and spectroscopic evidences. The detailed synthesis, spectroscopic data, and pharmacological activities were reported.
authors.affiliation: Pharmacology and Toxicology Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Naif O
authors.initials: NO
authors.lastname: Al-Harbi
authors.forename: Saleh A
authors.initials: SA
authors.lastname: Bahashwan
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Fayed
authors.forename: Moutasem S
authors.initials: MS
authors.lastname: Aboonq
authors.forename: Abd El-Galil E
authors.initials: Ael-G
authors.lastname: Amr
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000978:Antiparkinson Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000254:growth & development*; D001419:Bacteria / Q000254:growth & development*; D002176:Candida albicans / Q000254:growth & development*; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D000978:Antiparkinson Agents; D006574:Heterocyclic Compounds, 2-Ring; D007004:Hypoglycemic Agents