title: Use of nitric oxide producer L-arginine during infusion therapy of experimental hemorrhagic shock.
abstract: Experiments on rats showed that infusion of NO precursor L-arginine before bleeding enhanced their tolerance to hemorrhagic shock. When infused after blood loss as a component of saline solution, L-arginine improved efficiency of infusion therapy for hemorrhagic shock and increased survival rate of the animals.
authors.affiliation: Department of Blood Substitutes and Components, Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological Agency, St. Petersburg, Russia. bloodscience@mail.ru
authors.forename: G V
authors.initials: GV
authors.lastname: Grishina
authors.forename: K A
authors.initials: KA
authors.lastname: Gerbut
authors.forename: M I
authors.initials: MI
authors.lastname: Remizova
authors.forename: E A
authors.initials: EA
authors.lastname: Selivanov
mesh_terms: D000138:Acidosis / Q000188:drug therapy; D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D062186:Arterial Pressure / Q000187:drug effects*; D001775:Blood Circulation / Q000187:drug effects*; D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D009569:Nitric Oxide / Q000096:biosynthesis; D051381:Rats; D012771:Shock, Hemorrhagic / Q000188:drug therapy*
chemical_list: D009569:Nitric Oxide; D001120:Arginine