title: Differential expression of CXCL1, CXCL9, CXCL10 and CXCL12 chemokines in alopecia areata.
abstract: BACKGROUND
  Alopecia Areata (AA) is a non-scarring, autoimmune disorder which causes hair loss. Inflammatory reactions are involved in hair loss of the scalp and/or body. The involvement of chemokine receptors in the pathogenesis of AA is well defined among which, CXCL1 acts on neutrophils and CXCL9, CXCL10 and CXCL12 serve as T lymphocytes recruiters.
  
  
  OBJECTIVE
  To study the serum levels of ELR+ and ELR- CXCL1, CXCL9, CXCL10 and CXCL12 in the patients suffering from AA and healthy controls.
  
  
  METHODS
  The study population consisted of 30 patients suffering from AA and 30 healthy controls. Serum concentrations of CXCL1, CXCL9, CXCL10 and CXCL12 were measured using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Current results showed that AA patients had significantly elevated serum levels of CXCL9 and CXCL10 in comparison to controls (p<0.001). These results also demonstrated that serum levels of CXCL1 and CXCL12 were significantly decreased in AA patients compared to control (p<0.001).
  
  
  CONCLUSIONS
  CXCL9 and CXCL10 are elevated in the AA patients and may be involved in the recruitment of T lymphocytes to the inflamed tissues. Moreover, due to the significant role played by these chemokines in angiogenesis/angiostatis phenomenon they could be considered as useful biomarkers in AA diagnosis and therapy.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, afshinmirzaeik@yahoo.com.
authors.forename: Nahid
authors.initials: N
authors.lastname: Zainodini
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Hassanshahi
authors.forename: Mohammad Kazemi
authors.initials: MK
authors.lastname: Arababadi
authors.forename: Hossein
authors.initials: H
authors.lastname: Khorramdelazad
authors.forename: Afshin
authors.initials: A
authors.lastname: Mirzaei
mesh_terms: D000293:Adolescent; D000328:Adult; D000506:Alopecia Areata / Q000175:diagnosis / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D054360:Chemokine CXCL1 / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D054357:Chemokine CXCL10 / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D054377:Chemokine CXCL12 / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D054370:Chemokine CXCL9 / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054360:Chemokine CXCL1; D054357:Chemokine CXCL10; D054377:Chemokine CXCL12; D054370:Chemokine CXCL9; D011956:Receptors, Cell Surface; C557651:elastin-laminin receptor, human