title: Liver Oxidative Stress after Renal Ischemia-Reperfusion Injury is Leukocyte Dependent in Inbred Mice.
abstract: OBJECTIVE
  There are some reports in recent years indicating that renal ischemia - reperfusion (IR) induces deleterious changes in remote organs such as liver. The aim of this study was to investigate whether leukocytes have a role on the induction of oxidative stress in liver after renal IR.
  
  
  METHODS
  Inbred mice in IR donor group were subjected to renal IR injury. In sham donor group the procedure was almost the same except that ischemia was not induced. Then, mice were anesthetized and blood was collected. Leukocytes were isolated from donor groups and were then transferred to intact recipient mice (from IR donor mice to IR recipient mice and from sham donor mice to sham recipient mice).
  
  
  RESULTS
  After 24 hr, hepatic superoxide dismutase (SOD) and catalase (CAT) activities decreased significantly in recipient mice that received leukocytes from IR donor mice in comparison to recipient mice received leukocytes from sham donor mice.
  
  
  CONCLUSIONS
  These findings indicate that leukocytes are one of the mediators that induce hepatic oxidative stress after renal IR.
authors.affiliation: School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Khastar
authors.forename: Mehri
authors.initials: M
authors.lastname: Kadkhodaee
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Sadeghipour
authors.forename: Behjat
authors.initials: B
authors.lastname: Seifi
authors.forename: Jamshid
authors.initials: J
authors.lastname: Hadjati
authors.forename: Atefeh
authors.initials: A
authors.lastname: Najafi
authors.forename: Manoocher
authors.initials: M
authors.lastname: Soleimani
keywords: Leukocyte; Liver; Oxidative stress; Renal ischemia