title: Evaluation of structural and functional changes in non-pathologic myopic fundus using multifocal electroretinogram and optical coherence tomography.
abstract: OBJECTIVE
  To evaluate structural and functional changes in non-pathologic myopic fundus using multifocal electroretinogram (mfERG) and spectral domain-optical coherence tomography (SD-OCT).
  
  
  METHODS
  A total of 90 myopic subjects underwent mfERG and SD-OCT. The subjects were divided into four groups according to spherical equivalent refractive error: Group 1 (-0.50 to -2.75 D), Group 2 (-3.00 to -5.75 D), Group 3 (-6.00 to -9.75 D), and Group 4 (-10.0 to -15.0 D). Total retinal thickness, photoreceptor retinal thickness (PR), outer nuclear retinal thickness and mid-inner retinal thickness (MIR) were measured using SD-OCT in foveola and two perifoveal retinal regions 2.0 mm nasal and temporal from the foveola. The amplitude and implicit time of N1 and P1 mfERG responses were analyzed using six-concentric-ring grouping. Correlations between each retinal thickness, amplitude, and implicit time among the four myopic groups were analyzed.
  
  
  RESULTS
  PR thickness in the foveola and MIR thickness in the perifoveal retina were significantly reduced with increasing myopic refractive errors (p = 0.001, respectively). Significant correlations appeared between N1 amplitude, P1 amplitude, P1 implicit time, and refractive errors (p = 0.001, respectively). Significant correlations appeared between MIR thickness and N1, P1 amplitude (p = 0.001, respectively) as well as N1, P1 implicit time (p = 0.02 and 0.03, respectively) in the perifoveal retina corresponding to ring 4.
  
  
  CONCLUSIONS
  The correlation between structural and functional changes in myopia should be considered when interpreting retinal structure and function using SD-OCT and mfERG, especially in high myopia.
authors.affiliation: Department of Ophthalmology, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital, #1174 Jung-dong, Wonmi-gu, Bucheon 420-767, Korea.
authors.forename: Saemi
authors.initials: S
authors.lastname: Park
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Tae Kwann
authors.initials: TK
authors.lastname: Park
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Ohn
mesh_terms: D000328:Adult; D004596:Electroretinography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology / Q000503:physiopathology; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000473:pathology* / Q000503:physiopathology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D055815:Young Adult