title: Integrative genomic analyses of recepteur d'origine nantais and its prognostic value in cancer.
abstract: Recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) normally expressed at low levels in epithelial cells. RON is a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity. The extracellular sequences of RON contain several domains including an N-terminal semaphorin (sema) domain, followed by the plexin, semaphorin, integrin (PSI) domain, and four immunoglobulin, plexin, transcription factor (IPT) domains. Here, we identified RON genes from 14 vertebrate genomes and found that RON exists in all types of vertebrates including fish, amphibians, birds and mammals. We found that the human RON gene showed predominant expression in the liver, lymph node, thymus, intestine, lung, mammary gland, bone marrow, brain, heart, placenta, bladder, cortex, cervix, skin, kidney and prostate. When searched in the PrognoScan database, human RON was also found to be expressed in bladder, blood, breast, glioma, esophageal, colorectal, head and neck, ovarian, lung and skin cancer. The relationship between the expression of RON and prognosis was found to vary in different cancer types, even in the same cancer from different databases. This suggests that the function of RON in these tumors may be multidimensional, not just as a tumor suppressor or oncogene. Six available single-nucleotide polymorphisms (SNPs) disrupting existing exonic splicing enhancers were identified in RON. This may contribute to the generation of active RON variants by alternative splicing, which is frequently observed in primary tumors.
authors.affiliation: Department of Clinical Laboratory of the Traditional Chinese Medical Hospital of Nantong City, Nantong, Jiangsu, P.R. China. huizhongyu999@gmail.com
authors.forename: Haizhong
authors.initials: H
authors.lastname: Yu
authors.forename: Jianfen
authors.initials: J
authors.lastname: Yuan
authors.forename: Chunhong
authors.initials: C
authors.lastname: Xiao
authors.forename: Yi
authors.initials: Y
authors.lastname: Qin
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D016678:Genome / Q000235:genetics; D023281:Genomics; D006801:Humans; D015201:Meta-Analysis as Topic; D009369:Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis; D040901:Proteomics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D014714:Vertebrates / Q000235:genetics
chemical_list: C080835:RON protein; D020794:Receptor Protein-Tyrosine Kinases