title: Polymorphisms of paraoxonase 1 and 2 genes and the risk of multiple sclerosis in the Polish population.
abstract: OBJECTIVE
  The aim of this study was to test the hypothesis that polymorphisms of the paraoxonase genes PON1 and PON2 may be associated with increased risk of developing multiple sclerosis (MS) in the Polish population.
  
  
  METHODS
  We studied the significance of the PON gene polymorphisms C311S, A162G, Q192R and L55M in 221 patients (including 145 women) with MS and in 661 healthy controls. In the MS population, mean Expanded Disability Status Scale score was 2.92, mean age was 36.8 years, and mean disease duration was 7.7 years. PON genotyping was determined using polymerase chain reaction and restriction enzyme digestion.
  
  
  RESULTS
  According to our results, the PON1 and PON2 genotypes distribution did not differ between the MS patients and the controls.
  
  
  CONCLUSIONS
  The polymorphisms of the PON genes studied are not related to increased risk of MS in the Polish population.
authors.affiliation: Katedra i Klinika Neurologii, Warszawski Uniwersytet Medyczny, Warszawa, Polska. beata.zakrzewska-pniewska@wum.edu.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Zakrzewska-Pniewska
authors.forename: Monika
authors.initials: M
authors.lastname: Nojszewska
authors.forename: Teresa
authors.initials: T
authors.lastname: Róg
authors.forename: Jarosław
authors.initials: J
authors.lastname: Pniewski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Dorobek
authors.forename: Maria
authors.initials: M
authors.lastname: Styczyńska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szczudlik
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics* / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C468411:PON2 protein, human