title: Genetic analysis of the FBXO48 gene in Chinese Han patients with Parkinson disease.
abstract: The F-box only protein 48 gene (FBXO48) is located in 2p13.3, the disease gene locus of Parkinson disease type 3 (PARK3), and it is one of the paralogs of the F-box only protein 7 gene (FBXO7), which is a causative gene of the Parkinson disease type 15 (PARK15; also known as Parkinsonian-pyramidal disease, PPD). To determine whether genetic mutation in the coding region of the FBXO48 gene plays a role in the etiology of PD, we screened DNA samples from 350 Chinese Han patients with PD. No mutation in the coding region of the FBXO48 gene was identified in our PD cohort, suggesting that mutations in the coding region of the FBXO48 gene play little or no role in the development of PD.
authors.affiliation: Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Xiu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Song
authors.forename: Kai
authors.initials: K
authors.lastname: Gao
authors.forename: Xiong
authors.initials: X
authors.lastname: Deng
authors.forename: Yong
authors.initials: Y
authors.lastname: Qi
authors.forename: Anding
authors.initials: A
authors.lastname: Zhu
authors.forename: Lina
authors.initials: L
authors.lastname: Gong
authors.forename: Hao
authors.initials: H
authors.lastname: Deng
mesh_terms: D000368:Aged; D044466:Asian People; D044783:F-Box Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*
chemical_list: D044783:F-Box Proteins