title: Analytical and theranostic applications of gold nanoparticles and multifunctional nanocomposites.
abstract: Gold nanoparticles (GNPs) and GNP-based multifunctional nanocomposites are the subject of intensive studies and biomedical applications. This minireview summarizes our recent efforts in analytical and theranostic applications of engineered GNPs and nanocomposites by using plasmonic properties of GNPs and various optical techniques. Specifically, we consider analytical biosensing; visualization and bioimaging of bacterial, mammalian, and plant cells; photodynamic treatment of pathogenic bacteria; and photothermal therapy of xenografted tumors. In addition to recently published reports, we discuss new data on dot immunoassay diagnostics of mycobacteria, multiplexed immunoelectron microscopy analysis of Azospirillum brasilense, materno-embryonic transfer of GNPs in pregnant rats, and combined photodynamic and photothermal treatment of rat xenografted tumors with gold nanorods covered by a mesoporous silica shell doped with hematoporphyrin.
authors.affiliation: Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS), Russian Federation. khlebtsov@ibppm.sgu.ru
authors.forename: Nikolai
authors.initials: N
authors.lastname: Khlebtsov
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bogatyrev
authors.forename: Lev
authors.initials: L
authors.lastname: Dykman
authors.forename: Boris
authors.initials: B
authors.lastname: Khlebtsov
authors.forename: Sergey
authors.initials: S
authors.lastname: Staroverov
authors.forename: Alexander
authors.initials: A
authors.lastname: Shirokov
authors.forename: Larisa
authors.initials: L
authors.lastname: Matora
authors.forename: Vitaly
authors.initials: V
authors.lastname: Khanadeev
authors.forename: Timofey
authors.initials: T
authors.lastname: Pylaev
authors.forename: Natalia
authors.initials: N
authors.lastname: Tsyganova
authors.forename: Georgy
authors.initials: G
authors.lastname: Terentyuk
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000175:diagnosis / Q000628:therapy; D003952:Diagnostic Imaging / Q000379:methods; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000008:administration & dosage / Q000528:radiation effects; D006046:Gold / Q000528:radiation effects / Q000627:therapeutic use*; D006801:Humans; D053761:Nanocomposites / Q000528:radiation effects / Q000627:therapeutic use*; D053758:Nanoparticles / Q000528:radiation effects / Q000627:therapeutic use*; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D010789:Phototherapy / Q000379:methods; D051381:Rats
chemical_list: D004337:Drug Carriers; D006046:Gold
keywords: Azospirillum brasilense; DNA detection; Gold nanoparticles; cell bioimaging; immunoassay; materno-embryonic transfer of gold nanoparticles.; multifunctional nanocomposites; mycobacteria; photodynamic and photothermal therapy; placental barrier