title: Peptidomics in drug research.
abstract: BACKGROUND
  Because of their wide range of functions, endogenous peptides have great potential either as drugs themselves or as drug targets.
  
  
  OBJECTIVE
  To provide an overview of the current use of peptides as drugs (targets) and describe how improvements in peptide biochemistry and the application of peptidomics studies can lead to the discovery of new diagnostic and therapeutic targets.
  
  
  METHODS
  We discuss the different peptidomics technologies and their application in the study of human and animal disease models, animal venoms, antimicrobial peptides, G-protein-coupled receptor ligands and biomarkers.
  
  
  CONCLUSIONS
  At present, peptide drugs represent a small but growing number of pharmaceutical molecules. The peptidomics methodology, which was introduced 7 years ago to study naturally occurring peptides, will lead to a plethora of new peptide drug leads.
authors.affiliation: Research Group Functional Genomics and Proteomics, K.U. Leuven, Naamsestraat 59, 3000 Leuven, Belgium +32 16 324260 ; +32 16 323902 ; Elke.Clynen@bio.kuleuven.be.
authors.forename: E
authors.initials: E
authors.lastname: Clynen
authors.forename: G
authors.initials: G
authors.lastname: Baggerman
authors.forename: Sj
authors.initials: S
authors.lastname: Husson
authors.forename: B
authors.initials: B
authors.lastname: Landuyt
authors.forename: L
authors.initials: L
authors.lastname: Schoofs