title: UVA radiation induced ultrafast electron transfer from a food carcinogen benzo[a]pyrene to organic molecules, biological macromolecules, and inorganic nano structures.
abstract: Reactions involving electron transfer (ET) and reactive oxygen species (ROS) play a pivotal role in carcinogenesis and cancer biochemistry. Our present study emphasizes UVA radiation induced ET reaction as one of the key aspects of a potential carcinogen, benzo[a]pyrene (BP), in the presence of a wide variety of molecules covering organic p-benzoquinone (BQ), biological macromolecules like calf-thymus DNA (CT-DNA), human serum albumin (HSA) protein, and inorganic zinc oxide (ZnO) nanorods (NRs). Steady-state and picosecond-resolved fluorescence spectroscopy have been used to monitor such ET reactions. Physical consequences of BP association with CT-DNA have been investigated through temperature-dependent circular dichroism (CD) spectroscopy. The temperature-dependent steady-state, picosecond-resolved fluorescence lifetime and anisotropy studies reveal the effect of temperature on the perturbation of such ET reactions from BP to biological macromolecules, highlighting their temperature-dependent association. Furthermore, the electron-donating property of BP has been corroborated by measuring wavelength-dependent photocurrent in a BP-anchored ZnO NR-based photodevice, offering new physical insights for the carcinogenic study of BP.
authors.affiliation: UNANST, Department of Chemical, Biological & Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, India.
authors.forename: Soma
authors.initials: S
authors.lastname: Banerjee
authors.forename: Soumik
authors.initials: S
authors.lastname: Sarkar
authors.forename: Karthik
authors.initials: K
authors.lastname: Lakshman
authors.forename: Joydeep
authors.initials: J
authors.lastname: Dutta
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Pal
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene / Q000737:chemistry*; D016227:Benzoquinones / Q000737:chemistry; D002273:Carcinogens / Q000737:chemistry*; D002417:Cattle; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D004579:Electron Transport; D004583:Electrons; D006801:Humans; D043942:Nanotubes / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014466:Ultraviolet Rays; D015034:Zinc Oxide / Q000737:chemistry
chemical_list: D016227:Benzoquinones; D002273:Carcinogens; D017382:Reactive Oxygen Species; D012710:Serum Albumin, Bovine; D001564:Benzo(a)pyrene; D004247:DNA; C427203:calf thymus DNA; D015034:Zinc Oxide