title: Comparison of posterior capsule opacification and glistenings with 2 hydrophobic acrylic intraocular lenses: 5- to 7-year follow-up.
abstract: OBJECTIVE
  To compare posterior capsule opacification (PCO) and glistenings 5 to 7 years after cataract surgery with implantation of 2 hydrophobic acrylic intraocular lenses (IOLs) and evaluate the effects on corrected distance visual acuity (CDVA) and contrast sensitivity.
  
  
  METHODS
  St. Erik Eye Hospital, Stockholm, Sweden.
  
  
  METHODS
  Randomized clinical trial.
  
  
  METHODS
  Cataract surgery with standard phacoemulsification was performed in 1 eye of patients. The patients were randomized to an Acrysof SA60AT (1-piece IOL group) or a Sensar AR40e (3-piece IOL group), both hydrophobic acrylic IOLs with a sharp-edged design. Five to 7 years postoperatively, retroillumination images were obtained and the PCO area and severity (area affected within the capsulorhexis and severity) were evaluated using computer software. High-contrast (100%) and low-contrast (2.5%) CDVAs were measured. The neodymium:YAG laser capsulotomy rates were recorded. Scheimpflug images were obtained to evaluate glistenings, which were graded subjectively at the slitlamp and quantified objectively by digital image analysis using computer software.
  
  
  RESULTS
  The study enrolled 80 patients. There were no significant differences in PCO between the 2 groups. The 3-piece IOL group had significantly fewer glistenings (P<.001). There was good correlation between the subjective grading of glistenings and objective computer-processed image grading. The glistenings were not correlated with IOL power, CDVA, or contrast sensitivity.
  
  
  CONCLUSIONS
  There were no significant differences in PCO between the 2 acrylic hydrophobic IOLs 5 to 7 years postoperatively. The 1-piece IOL group developed more glistenings than the 3-piece IOL group.
authors.affiliation: St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Anthony
authors.initials: A
authors.lastname: Chang
authors.forename: Anders
authors.initials: A
authors.lastname: Behndig
authors.forename: Margrethe
authors.initials: M
authors.lastname: Rønbeck
authors.forename: Maria
authors.initials: M
authors.lastname: Kugelberg
mesh_terms: D000180:Acrylic Resins; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058442:Capsule Opacification / Q000209:etiology* / Q000601:surgery; D019923:Capsulorhexis; D015350:Contrast Sensitivity / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053844:Lasers, Solid-State / Q000627:therapeutic use; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D045423:Microbubbles; D008875:Middle Aged; D018918:Phacoemulsification; D057852:Posterior Capsule of the Lens / Q000473:pathology* / Q000601:surgery; D011183:Postoperative Complications; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000180:Acrylic Resins