title: Palladium-catalyzed oxidative insertion of carbon monoxide to N-sulfonyl-2-aminobiaryls through C-H bond activation: access to bioactive phenanthridinone derivatives in one pot.
abstract: Palladium-catalyzed oxidative carbonylation of N-sulfonyl-2-aminobiaryls through C-H bond activation and C-C, C-N bond formation under TFA-free and milder conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important phenanthridinone derivatives in yields up to 94%.
authors.affiliation: Department of Applied Chemistry, National Chiao Tung University, Hsinchu 30010, Taiwan, ROC.
authors.forename: Venkatachalam
authors.initials: V
authors.lastname: Rajeshkumar
authors.forename: Tai-Hua
authors.initials: TH
authors.lastname: Lee
authors.forename: Shih-Ching
authors.initials: SC
authors.lastname: Chuang
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D047151:Amaryllidaceae Alkaloids; D010616:Phenanthrenes; D010165:Palladium; D002248:Carbon Monoxide