title: Can sinogram-affirmed iterative (SAFIRE) reconstruction improve imaging quality on low-dose lung CT screening compared with traditional filtered back projection (FBP) reconstruction?
abstract: OBJECTIVE
  To evaluate the performance of sinogram-affirmed iterative (SAFIRE) reconstruction on image quality of low-dose lung computed tomographic (CT) screening compared with filtered back projection (FBP).
  
  
  METHODS
  Three hundred four patients for annual low-dose lung CT screening were examined by a dual-source CT system at 120 kilovolt (peak) with reference tube current of 40 mA·s. Six image serials were reconstructed, including one data set of FBP and 5 data sets of SAFIRE with different reconstruction strengths from 1 to 5. Image noise was recorded; and subjective scores of image noise, images artifacts, and the overall image quality were also assessed by 2 radiologists.
  
  
  RESULTS
  The mean ± SD weight for all patients was 66.3 ± 12.8 kg, and the body mass index was 23.4 ± 3.2. The mean ± SD dose-length product was 95.2 ± 30.6 mGy cm, and the mean ± SD effective dose was 1.6 ± 0.5 mSv. The observation agreements for image noise grade, artifact grade, and the overall image quality were 0.785, 0.595 and 0.512, respectively. Among the overall 6 data sets, both the measured mean objective image noise and the subjective image noise of FBP was the highest, and the image noise decreased with the increasing of SAFIRE reconstruction strength. The data sets of S3 obtained the best image quality scores.
  
  
  CONCLUSIONS
  Sinogram-affirmed iterative reconstruction can significantly improve image quality of low-dose lung CT screening compared with FBP, and SAFIRE with reconstruction strength 3 was a pertinent choice for low-dose lung CT.
authors.affiliation: Department of Radiology, Rui Jin Hospital, Medical School, Shanghai Jiao Tong University, Shanghai, PR China.
authors.forename: Wen Jie
authors.initials: WJ
authors.lastname: Yang
authors.forename: Fu Hua
authors.initials: FH
authors.lastname: Yan
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Li Fang
authors.initials: LF
authors.lastname: Pang
authors.forename: Liang
authors.initials: L
authors.lastname: Hou
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.forename: Zi Lai
authors.initials: ZL
authors.lastname: Pan
authors.forename: Ke Min
authors.initials: KM
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000704:Analysis of Variance; D016477:Artifacts; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*