title: Update on donor-derived infections in liver transplantation.
abstract: Advances in surgical techniques, immunosuppressive medications, and robust infectious disease prophylaxis have resulted in liver transplantation becoming the treatment of choice for patients with end-stage liver disease and unresectable hepatocellular carcinoma. Nonetheless, organ transplantation is not without risk. Unexpected donor-derived disease transmission is a newly recognized risk that complicates approximately 0.2% of all organ transplants. We review the epidemiology of donor-derived infectious diseases and methods of risk mitigation with a focus on liver transplantation.
authors.affiliation: Division of Infectious Diseases, Northwestern University Transplant Outcomes Research Collaboration, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Ignacio A
authors.initials: IA
authors.lastname: Echenique
authors.forename: Michael G
authors.initials: MG
authors.lastname: Ison
mesh_terms: D001424:Bacterial Infections / Q000453:epidemiology; D046148:Donor Selection; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017093:Liver Failure / Q000628:therapy*; D016031:Liver Transplantation / Q000009:adverse effects*; D009181:Mycoses / Q000453:epidemiology; D010272:Parasitic Diseases / Q000453:epidemiology; D012306:Risk; D014019:Tissue Donors; D014777:Virus Diseases / Q000453:epidemiology
chemical_list: D007166:Immunosuppressive Agents