title: Assessment of the elasticity properties of the ascending aorta in patients with subclinical hypothyroidism by tissue Doppler imaging.
abstract: OBJECTIVE
  We aimed to investigate whether aortic elastic properties were affected in subclinical hypothyroidism (SCH) by using tissue Doppler imaging (TDI).
  
  
  METHODS
  Forty-three patients with newly diagnosed SCH and forty-eight healthy controls were included to the study. Systolic and diastolic diameters of the ascending aorta were measured by M-mode transthoracic echocardiography, and the upper wall velocities of ascending aorta and mitral annulus velocities were measured by TDI. Aortic stiffness index (ASI) and aortic distensibility were computed using the formulas accepted in literature.
  
  
  RESULTS
  The clinical and demographic features of both groups were comparable. Aortic distensibility was significantly lower, and ASI was significantly higher in SCH patients than in controls. Systolic aortic upper wall velocity (Sao) was also significantly lower in SCH patients. Early (Eao) and late diastolic aortic upper wall (Aao) velocities did not differ between the two groups. Mitral annulus (Sm, Em, and Am) velocities were also similar between the groups. Sao was negatively correlated with ASI, and positively correlated with aortic distensibility. TSH level was positively correlated with ASI, total cholesterol and low-density lipoprotein-cholesterol, and negatively correlated with aortic distensibility and Sao.
  
  
  CONCLUSIONS
  In this study, our results showed that SCH is associated with impaired elasticity of the ascending aorta. Elastic properties of the ascending aorta can be directly evaluated by the reproducibly measurement of the upper wall movements of the ascending aorta by TDI in SCH patients.
authors.affiliation: Lokman Hekim Hospital, Department of Cardiology, Van, Turkey. mustafayurtdas@yahoo.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yurtdaş
authors.forename: Ramazan
authors.initials: R
authors.lastname: Gen
authors.forename: Turkay
authors.initials: T
authors.lastname: Özcan
authors.forename: Mehmet Kasim
authors.initials: MK
authors.lastname: Aydın
mesh_terms: D000328:Adult; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D004548:Elasticity / Q000502:physiology*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D059289:Vascular Stiffness / Q000502:physiology*