title: Hypoxia-inducible factor-1α as prognostic marker.
abstract: BACKGROUND
  Hypoxia-inducible factor-1α (HIF-1α) is a key player in the signaling pathway that mediates a complex and pleiotropic range of adaptive responses to hypoxia. It serves as cellular hypoxia sensor and plays a critical role in physiologic processes including glucose metabolism, iron metabolism, erythropoiesis, angiogenesis, cell survival and apoptosis, but also, pathologic processes such as carcinogenesis, progression and metastasis of many cancers. With the recent advent of new molecular targeted therapies, there is a growing need of molecular understanding of physiology and physiopathology and increased demand of diagnosis, prognosis and follow-up markers.
  
  
  METHODS
  This paper reviews the biology of regulation of HIF-1α, its physiological and physiopathological effects.
  
  
  CONCLUSIONS
  The authors discuss the potential diagnosis and the prognosis significance of HIF-1α that was evaluated in recent studies.
authors.affiliation: Laboratoire de Biochimie et de Biologie moléculaire, Assistance Publique-Hôpitaux de Marseille (AP-HM), Hôpital Nord, Marseille, France. amin.benlassoued@ap-hm.fr
authors.forename: Amin
authors.initials: A
authors.lastname: Ben Lassoued
authors.forename: Nathalie
authors.initials: N
authors.lastname: Beaufils
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Dales
authors.forename: Jean
authors.initials: J
authors.lastname: Gabert
mesh_terms: D015415:Biomarkers / Q000032:analysis; D006331:Heart Diseases / Q000175:diagnosis*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000032:analysis*; D007249:Inflammation / Q000175:diagnosis*; D009369:Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D051795:Hypoxia-Inducible Factor 1, alpha Subunit