title: Analysis about the influence on the fetus infected with parvovirus B19 using amniotic erythropoietin and troponin-T.
abstract: OBJECTIVE
  We tried to identify the influence on the fetus infected with parvovirus B19 (PB19) and retrospectively analyze the severity of fetal infection.
  
  
  METHODS
  Twenty pregnant women who developed maternal PB19 infection were included in this study. A total of 20 amniotic fluid samples were collected for measurement of PB19-DNA, erythropoietin (Epo) and troponin-T (TnT).
  
  
  RESULTS
  Of the 5 fetuses with hydrops, 2 were rescued by fetal therapy. Significant differences between groups were found for Epo and TnT: Epo 107.1 ± 45.3 mU/ml and TnT 0.040 ± 0.028 ng/ml (mean ± standard deviation) for the symptomatic fetus group; and Epo 18.9 ± 13.7 mU/ml and TnT 0.008 ± 0.014 ng/ml for the asymptomatic fetus group (p = 0.043 for both variables). Setting Epo ≥50 mU/ml as the predictor of disease onset resulted in an Odds ratio of 56.0, with a 95 % confidence interval of 7.68-1,108.76.
  
  
  CONCLUSIONS
  The study has determined an amniotic Epo level of ≥50 mU/ml as a factor of the influence on the fetus infected with PB19. The measurement of amniotic Epo level combined with amniotic TnT level is effective for determining the severity of fetal hypoxia.
authors.affiliation: Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan. masashi0619@nifty.com
authors.forename: Masashi
authors.initials: M
authors.lastname: Yoshida
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsuda
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Yoshinaga
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Asai
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kawashima
authors.forename: Kiguna
authors.initials: K
authors.lastname: Sei
authors.forename: Miho
authors.initials: M
authors.lastname: Horii
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakanishi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Soyama
authors.forename: Kenichi
authors.initials: K
authors.lastname: Furuya
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D004921:Erythropoietin / Q000378:metabolism*; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000821:virology; D015999:Multivariate Analysis; D010322:Parvoviridae Infections / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D016732:Parvovirus B19, Human; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000000981:diagnostic imaging* / Q000378:metabolism; D012189:Retrospective Studies; D020107:Troponin T / Q000378:metabolism*; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D020107:Troponin T; D004921:Erythropoietin