title: Werner syndrome: a changing pattern of clinical manifestations in Japan (1917~2008).
abstract: As ~75% of the Werner syndrome (WS) patients recognized between 1904 and 2008 all over the world are of Japanese origin, the most case reports and clinical studies on WS has been published in Japanese journals. Thus, the detailed English-written clinical review on the recent WS case reports has been warranted. Although WS has been characterized by a variety of clinical manifestations mimicking premature aging, the recent longevity and delayed age-associated manifestations observed both from Japanese WS and general population may suggest a common environmental effect on some gene(s) other than WRN and may give us a newer pathophysiological look at WS and also natural aging through the molecular dysfunction of WRN.
authors.affiliation: Division of Orthopedic Surgery & Rheumatology, East Medical Center, Tokyo Women's Medical University, Tokyo, Japan. werner.goto@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: M
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Furuichi
mesh_terms: D000328:Adult; D019588:Aging, Premature / Q000235:genetics / Q000503:physiopathology*; D005090:Exodeoxyribonucleases / Q000235:genetics*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D009154:Mutation; D053484:RecQ Helicases / Q000235:genetics*; D014898:Werner Syndrome / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D000071657:Werner Syndrome Helicase
chemical_list: D005090:Exodeoxyribonucleases; D053484:RecQ Helicases; C098785:WRN protein, human; D000071657:Werner Syndrome Helicase