title: The design of an enzyme: a chronology on the controversy.
abstract: After the publication of the Monod-Wyman-Changeux model, a controversy arose between Jacques Monod, Francis Crick and Jeffries Wyman about the comparison of the regulatory performances of an oligomer undergoing a concerted transition between two states and a monomer having the same composition and subjected to a similar conformational equilibrium. The controversy took place between September 1965 and March 1966. It gave rise to several unpublished notes. Numerous misunderstandings between the participants were not fully dissipated as the controversy abruptly ended.
authors.affiliation: Archives of the Pasteur Institute, Centre d'Information Scientifique, Paris, France. henribuc@pasteur.fr
authors.forename: Henri
authors.initials: H
authors.lastname: Buc
mesh_terms: D000494:Allosteric Regulation; D004798:Enzymes / Q000138:chemical synthesis* / Q000266:history* / Q000378:metabolism; D049673:History, 20th Century; D008958:Models, Molecular; D011487:Protein Conformation; D020836:Protein Structure, Quaternary
chemical_list: D004798:Enzymes