title: A PHD in histone language: on the role of histone methylation in plant responses to phosphate deficiency.
abstract: Post-translational modifications of core histones are important for various DNA-templated processes such as transcription and repair. We recently reported that the ALFIN LIKE 6 (AL6) gene, identified in a forward genetic screen, is critical for phosphate deficiency-induced root hair formation and several other processes associated with the regulation of cellular phosphate homeostasis. AL6 contains a Plant Homeo Domain (PHD) finger that can bind to trimethylated lysine 4 of histone H3 (H3K4me3). Homozygous mutants defective in AL6 expression form very short root hairs under phosphate-deficient conditions, presumably caused by altered expression of putative primary and secondary down-stream targets of AL6. In this Addendum, we speculate about possible roles of AL6, H3K4 trimethylation and other chromatin modifications in the adaptation of plants to low phosphate availability.
authors.affiliation: Molecular and Cell Biology; Taiwan International Graduate Program; Academia Sinica; Graduate Institute of Life Sciences; National Defense Medical Center; Taipei, Taiwan; Institute of Plant and Microbial Biology; Academia Sinica; Taipei, Taiwan.
authors.forename: Nulu Naga Prafulla
authors.initials: NN
authors.lastname: Chandrika
authors.forename: Kalaipandian
authors.initials: K
authors.lastname: Sundaravelpandian
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schmidt
mesh_terms: D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000378:metabolism*; D008745:Methylation; D010710:Phosphates / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: C584518:ALFIN-LIKE 6 protein, Arabidopsis; D029681:Arabidopsis Proteins; D006657:Histones; D018398:Homeodomain Proteins; D010710:Phosphates; D014157:Transcription Factors
keywords: PHD finger; chromatin modificiations; histone methylation; phosphate deficiency; root hairs