title: Relationship between chemokine (C-X-C motif) ligand 12 gene variant (rs1746048) and coronary heart disease: case-control study and meta-analysis.
abstract: The goal of our study is to evaluate the contribution of CXCL12 rs1746048 (hg19, chr10:44775574) to the risk of CHD in Han Chinese, and to summarize its role in CHD through meta-analysis of existing studies among various ethnic groups. Significant association is observed between rs1746048-C and an increased risk of CHD in Han Chinese (χ(2)=5.41, df=1, P=0.02). Post hoc analysis reveals an even stronger association of rs1746048 with the risk of CHD for subjects aged 65 years or older (genotype: χ(2)=8.39, df=2, P=0.015; allele: χ2=9.13, df=1, P=0.003, odd ratio (OR)=1.91, 95% confidential interval (CI)=1.25-2.91). A break down analysis by gender shows that rs1746048 is likely a CHD risk factor under the recessive model in males (CC+CT versus TT: P=0.05, χ(2)=3.59, df=1, OR=1.72, 95% CI=1.00-3.04). In addition, a meta-analysis of ten studies among over 107,000 individuals confirms that rs1746048 is a risk factor of CHD (P<0.0001, OR=1.12, 95% CI=1.09-1.15) and this agrees with the findings of our case-control study in Han Chinese.
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Jianqing
authors.initials: J
authors.lastname: Zhou
authors.forename: Huadan
authors.initials: H
authors.lastname: Ye
authors.forename: Limin
authors.initials: L
authors.lastname: Xu
authors.forename: Yanping
authors.initials: Y
authors.lastname: Le
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Weifeng
authors.initials: W
authors.lastname: Xu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Huang
authors.forename: Jiangfang
authors.initials: J
authors.lastname: Lian
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
mesh_terms: D000368:Aged; D020816:Amino Acid Motifs; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D054377:Chemokine CXCL12 / Q000235:genetics*; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12