title: Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice.
abstract: The cancer chemopreventive potential of sarcophine-diol in a chemical carcinogen initiation-promotion experimental tumor model in mice was evaluated. Sarcophine-diol, when given orally, afforded significant protection in the mouse skin cancer model initiated by the topical administration of (+/-)-(E)-4-methyl-2-[(E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide (NOR-1) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA). These findings, along with our initial reports, suggest that sarcophine-diol is an effective cancer chemopreventive agent, even when administered orally and at a very low dose and thus indicating possible potential human applications in the control of malignancy.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA.
authors.forename: Pawel T
authors.initials: PT
authors.lastname: Szymanski
authors.forename: Safwat A
authors.initials: SA
authors.lastname: Ahmed
authors.forename: Sherief
authors.initials: S
authors.lastname: Khalifa
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Ichiishi
authors.forename: Akira
authors.initials: A
authors.lastname: Iida
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Suzuki
authors.forename: Hesham
authors.initials: H
authors.lastname: Fahmy
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology*; D005260:Female; D006898:Hydroxylamines / Q000494:pharmacology*; D051379:Mice; D008812:Mice, Hairless; D012878:Skin Neoplasms / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate
chemical_list: C477506:(+-)-E-4-methyl-2-((E)-hydroxylamino)-5-nitro-6-methoxy-3-hexanamide; D016588:Anticarcinogenic Agents; D004224:Diterpenes; D006898:Hydroxylamines; C573078:sarcophine-diol; D013755:Tetradecanoylphorbol Acetate