title: Antioxidative and therapeutic effects of spirulina on trichloroethylene induced cutaneous irritation balb/c mice.
abstract: OBJECTIVE
  To evaluate the antioxidative and therapeutic effects of spirulina on the trichloroethylene induced cutaneous irritation balb/c mice.
  
  
  BACKGROUND
  During recent years, an attention has been focused on the antioxidant potential of Spirulina species.
  
  
  METHODS
  Balb/c mice were randomized into the four groups. At the end of the each application, the rats were sacrificed and dorsal skin was taken. Histopathologic and immunohistochemical evaluations were conducted, oxidative stress was assessed by the measurement of malondialdehyde (MDA) levels, superoxide dismutase (SOD) activities and nitric oxide (NO) production.
  
  
  RESULTS
  There was a statistically significant decreased disruption in epidermal integrity, oedema in intercellular dermis, disorganization in collagen fibres and immunoreactivity in the pre acute dermatitis/ antioxidant and the post acute dermatitis/ treatment groups when compared to the acute dermatitis group (p<0.05).
  
  
  CONCLUSIONS
  The results of the present study indicate the antioxidative and therapeutic effects of Spirulina on trichloroethylene induced cutaneous irritation balb/c mice (Tab. 2, Fig. 8, Ref. 33).
authors.affiliation: Laboratory Animal Breeding and Experimental Research Centre, Faculty of Medicine, Gazi University, Ankara, Turkey. neslihan.gurbuz@gazi.edu.tr
authors.forename: N
authors.initials: N
authors.lastname: Gurbuz
authors.forename: Z K
authors.initials: ZK
authors.lastname: Coskun
authors.forename: S
authors.initials: S
authors.lastname: Omeroglu
authors.forename: A C
authors.initials: AC
authors.lastname: Bayraktar
authors.forename: Z
authors.initials: Z
authors.lastname: Ciraci
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005260:Female; D007509:Irritants / Q000633:toxicity*; D015227:Lipid Peroxidation; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress; D012871:Skin Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D053545:Spirulina; D014241:Trichloroethylene / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D007509:Irritants; D014241:Trichloroethylene