title: Unexpected selectivity in ruthenium-catalyzed hydrosilylation of primary amides: synthesis of secondary amines.
abstract: Selective ruthenium-catalyzed reductive coupling of primary amides under hydrosilylation conditions is achieved using an one pot procedure. Using 3 equiv. of phenylsilane and [RuCl2(mesitylene)]2 (1-2 mol%) as the catalyst at 100 °C under neat conditions, secondary symmetric amines were obtained in good yields and with high chemoselectivities.
authors.affiliation: UMR 6226 CNRS-Université Rennes1 Institut des Sciences Chimiques de Rennes-Centre of Catalysis and Green Chemistry-Organometallics: Materials and Catalysis, 35042 Rennes cedex, France.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Sortais
authors.forename: Christophe
authors.initials: C
authors.lastname: Darcel
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D017975:Ruthenium Compounds / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D017975:Ruthenium Compounds