title: Recent technologies in pulsatile drug delivery systems.
abstract: Pulsatile drug delivery systems (PDDS) have attracted attraction because of their multiple benefits over conventional dosage forms. They deliver the drug at the right time, at the right site of action and in the right amount, which provides more benefit than conventional dosages and increased patient compliance. These systems are designed according to the circadian rhythm of the body, and the drug is released rapidly and completely as a pulse after a lag time. These products follow the sigmoid release profile characterized by a time period. These systems are beneficial for drugs with chronopharmacological behavior, where nocturnal dosing is required, and for drugs that show the first-pass effect. This review covers methods and marketed technologies that have been developed to achieve pulsatile delivery. Marketed technologies, such as Pulsincap™, Diffucaps(®), CODAS(®), OROS(®) and PULSYS™, follow the above mechanism to render a sigmoidal drug release profile. Diseases wherein PDDS are promising include asthma, peptic ulcers, cardiovascular ailments, arthritis and attention deficit syndrome in children and hypercholesterolemia. Pulsatile drug delivery systems have the potential to bring new developments in the therapy of many diseases.
authors.affiliation: Bhagyoday Tirth Pharmacy College, Sagar, Madhya Pradesh, India.
authors.forename: Deepika
authors.initials: D
authors.lastname: Jain
authors.forename: Richa
authors.initials: R
authors.lastname: Raturi
authors.forename: Vikas
authors.initials: V
authors.lastname: Jain
authors.forename: Praveen
authors.initials: P
authors.lastname: Bansal
authors.forename: Ranjit
authors.initials: R
authors.lastname: Singh
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000639:trends*; D002940:Circadian Rhythm; D003692:Delayed-Action Preparations; D055870:Drug Chronotherapy; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations
keywords: capsular system; pulsatile drug delivery system; pulse; rupturable coating