title: Myocardial no-reflow treatment.
abstract: No-reflow phenomenon is a consequence of percutaneous coronary intervention (PCI) which arises most of the time in the setting of myocardial infarction, but can be also the consequence of PCI in stable angina patients (rotatablator ablation technique or angioplasty in saphenous vein grafts). In this review, we summarize two ways of treating the no-reflow according to the current literature. First through the pharmacological approach where several compounds have been assessed like adenosine, nitroprusside, verapamil, nicorandil, dipyridamole, epinephrine or cyclosporine. Second through the mechanical approach where few strategies have been examined like intra-aortic balloon pumping or postconditioning. Finally, we provide an algorithm for treating a no-reflow even though no studies showed a beneficial effect in terms of clinical endpoints.
authors.affiliation: Cardiology department, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 21, Lausanne, Switzerland.
authors.forename: Olivier
authors.initials: O
authors.lastname: Muller
authors.forename: Catalina
authors.initials: C
authors.lastname: Trana
authors.forename: Eric
authors.initials: E
authors.lastname: Eeckhout
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy; D054318:No-Reflow Phenomenon / Q000503:physiopathology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents