title: Association between MMP-1 g.-1607dupG polymorphism and periodontitis susceptibility: a meta-analysis.
abstract: BACKGROUND
  Matrix metalloproteinase-1 (MMP-1) plays an important role during the destruction of periodontal tissue. Although multiple studies had focused on the association between MMP-1 g.-1607dupG and periodontitis susceptibility, the results remained inconclusive. The purpose of this meta-analysis was to explore its role in the development of periodontitis.
  
  
  METHODS
  Retrieved studies from Pubmed, Web of Science, Medline and Google Scholar Search regarding MMP-1 g.-1607dupG and periodontitis susceptibility were included into the final analysis with definite selection and exclusion criteria. Overall and stratified analyses based on disease type, severity, ethnicity and smoking status were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the association between MMP-1 g.-1607dupG and periodontitis susceptibility, while Q test and Egger's test were adopted respectively to assess heterogeneity among studies and publication bias.
  
  
  RESULTS
  A total of 1580 periodontitis cases and 1386 controls in 11 case-control studies were included in the meta-analysis. The pooled results showed significant association between periodontitis susceptibility and MMP-1 g.-1607dupG polymorphism in homozygote (2G/2G versus 1G/1G, OR = 1.50, 95% CI = 1.02-2.20) and dominant model analysis (2G/2G+2G/1G versus 1G/1G, OR = 1.28, 95% CI = 1.04-1.57). For subgroups by type of periodontitis, increased risk of chronic periodontitis was observed on heterozygote (2G/1G versus 1G/1G, OR = 2.01, 95% CI = 1.58-2.56) and dominant model (OR = 1.27, 95% CI = 1.03-1.57). Furthermore, similar association was also detected in severe chronic periodontitis (2G/2G versus 1G/1G, OR = 2.15, 95% CI = 1.35-3.43; 2G/2G+2G/1G versus 1G/1G, OR = 1.64, 95% CI = 1.12-2.39; 2G/2G versus 2G/1G+1G/1G, OR = 1.86, 95% CI = 1.31-2.64).
  
  
  CONCLUSIONS
  Our meta-analysis demonstrated that MMP-1 g.-1607dupG polymorphism was associated with chronic periodontitis, especially the severity of the disease condition.
authors.affiliation: Institute of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Li
authors.forename: Qi
authors.initials: Q
authors.lastname: Cai
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Junqing
authors.initials: J
authors.lastname: Ma
authors.forename: Weibing
authors.initials: W
authors.lastname: Zhang
authors.forename: Yongchu
authors.initials: Y
authors.lastname: Pan
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016014:Linear Models; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D015233:Models, Statistical; D016017:Odds Ratio; D010518:Periodontitis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
chemical_list: D020781:Matrix Metalloproteinase 1