title: Aspirin use and risk of age-related macular degeneration: a meta-analysis.
abstract: BACKGROUND
  Age-related macular degeneration (AMD) is the main cause of blindness and the curative options are limited. The objective of this meta-analysis was to determine the association between aspirin use and risk of AMD.
  
  
  METHODS
  A comprehensive literature search was performed in PubMed, Embase, Web of Science, and reference lists. A meta-analysis was performed by STATA software.
  
  
  RESULTS
  Ten studies involving 171,729 individuals examining the association between aspirin use and risk of AMD were included. Among the included studies, 2 were randomized-controlled trials (RCTs), 4 were case-control studies and 4 were cohort studies. The relative risks (RRs) were pooled using a random-effects model. Relative risks with 95% confidence intervals (CIs) of aspirin use as a risk for AMD. The pooled RR of 10 included studies between the use of aspirin and risk of AMD was 1.09 (95% CI, 0.96-1.24). The same result was detected in early and late stage AMD subgroup analysis. In the subgroup analyses, the pooled RR of RCTs, case-control studies and cohort studies were 0.81 (95% CI, 0.64-1.02), 1.02 (95% CI, 0.92-1.14) and 1.08 (95% CI, 0.91-1.28), respectively.
  
  
  CONCLUSIONS
  The use of aspirin was not associated with the risk of AMD.
authors.affiliation: Department of Ophthalmology, Affiliated Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Ding
authors.initials: D
authors.lastname: Xu
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Li
authors.forename: Ba
authors.initials: B
authors.lastname: Jun
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
mesh_terms: D001241:Aspirin / Q000009:adverse effects*; D006801:Humans; D008268:Macular Degeneration / Q000139:chemically induced*; D012306:Risk
chemical_list: D001241:Aspirin