title: Self-assembly of DNA rings from scaffold-free DNA tiles.
abstract: We report a scaffold-free approach in which four- and six-helix DNA bundle units, assembled from a small number of single stranded DNA oligonucleotides precisely arranged in networks of contiguous and semicrossover strands, are connected into DNA nano rings. Nearly uniform structures with well-defined diameters of 53 ± 7, 81 ± 9, 85 ± 8, and 166 ± 13 nm were achieved by introducing uniform, in-plane curvature to the repeating units. We demonstrate that precise higher order assemblies can be achieved by fine tuning the particular features of the individual building blocks.
authors.affiliation: Center for Single Molecule Biophysics, the Biodesign Institute, Arizona State University, Tempe, Arizona 85287, United States.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Zhao
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.forename: Jeanette
authors.initials: J
authors.lastname: Nangreave
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
mesh_terms: D004247:DNA / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D004247:DNA