title: Allogeneic hematopoietic stem cell transplantation may restore gluten tolerance in patients with celiac disease.
abstract: We report on 2 patients affected by both celiac disease (CD) and β-thalassemia major who underwent successful myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for the latter condition. After HSCT, the introduction of a gluten-containing diet did not cause the reappearance of clinical, serological, and histological markers of CD in up to 5 years of follow-up. After transplantation, in both patients, dendritic cells and regulatory FoxP3T cells showed a recovery of normal values and no proliferative T-cell response upon gliadin stimulation was found. These data suggest that allogeneic HSCT may lead to induction of gluten tolerance in patients with CD.
authors.affiliation: Clinica Medica I, Fondazione IRCCS Policlinico San Matteo, Università degli Studi di Pavia, Piazzale Golgi 19, Pavia, Italy. rachele.ciccocioppo@unipv.it
authors.forename: Rachele
authors.initials: R
authors.lastname: Ciccocioppo
authors.forename: Maria Ester
authors.initials: ME
authors.lastname: Bernardo
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Russo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vanoli
authors.forename: Carla
authors.initials: C
authors.lastname: Franco
authors.forename: Myriam
authors.initials: M
authors.lastname: Martinetti
authors.forename: Laura
authors.initials: L
authors.lastname: Catenacci
authors.forename: Giovanna
authors.initials: G
authors.lastname: Giorgiani
authors.forename: Marco
authors.initials: M
authors.lastname: Zecca
authors.forename: Antonio
authors.initials: A
authors.lastname: Piralla
authors.forename: Fausto
authors.initials: F
authors.lastname: Baldanti
authors.forename: Franco
authors.initials: F
authors.lastname: Locatelli
authors.forename: Gino Roberto
authors.initials: GR
authors.lastname: Corazza
mesh_terms: D000293:Adolescent; D002446:Celiac Disease / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D002675:Child, Preschool; D005260:Female; D005983:Glutens / Q000009:adverse effects*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007108:Immune Tolerance; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D007422:Intestines / Q000276:immunology* / Q000473:pathology; D008297:Male; D014184:Transplantation, Homologous / Q000276:immunology; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000150:complications / Q000628:therapy
chemical_list: D005983:Glutens