title: Anti-inflammatory, antioxidant and cytotoxicity activities of methanolic extract and prenylated flavanones isolated from leaves of Eysehardtia platycarpa.
abstract: From the methanolic extract of Eysenhardtia platycarpa (leaves), were isolated the prenylated flavanones: 5,7-dihydroxy-6-methyl-8-prenylflavanone (1), 5,7-dihydroxy-6-methyl-8-prenyl-4'-methoxy-flavanone (2), 5,7-dihydroxy-6-prenylflavanone (3), 5-dihydroxy-7-methoxy-6-prenylflavanone (4), 5,7-dihydroxy-8-prenyl-4'-methoxy-flavanone (5). Methanolic extract of E. platycarpa (leaves) and flavanones (5), (2) and (3) showed anti-inflammatory activity according to tested quantities. In addition, flavanone (5) revealed the best percentage reduction of free radical DPPH. Finally, after cytotoxic activity study, the methanolic extract from E. platycarpa leaves and flavanone (4) exhibited promising cytotoxic activity on brine shrimp.
authors.affiliation: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001 Cuernavaca, Morelos, México.
authors.forename: Valeri
authors.initials: V
authors.lastname: Domínguez-Villegas
authors.forename: Vanessa
authors.initials: V
authors.lastname: Domínguez-Villegas
authors.forename: María Luisa
authors.initials: ML
authors.lastname: García
authors.forename: Ana
authors.initials: A
authors.lastname: Calpena
authors.forename: Beatriz
authors.initials: B
authors.lastname: Clares-Naveros
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Garduño-Ramírez
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001156:Artemia; D007887:Fabaceae / Q000737:chemistry*; D044950:Flavanones / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D044950:Flavanones; D010936:Plant Extracts