title: Tolerance to ischemia - an increasingly complex biology.
abstract: In this review we identify and discuss some of the genomics studies of preconditioning and the ischemic tolerance phenomenon. Such studies have been attempted in multiple species, using different array technologies and with different preconditioning and tolerance models. In addition, studies are starting to reveal epigenetic mechanisms and modifiers of tolerance and preconditioning. Together these studies are starting to reveal some of the immense complexity of the ischemic tolerance phenomenon, yet further studies await to be performed.
authors.affiliation: Neuroscience Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495 ; Department of Neurobiology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495 ; Department of Pharmacology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495.
authors.forename: Robert
authors.initials: R
authors.lastname: Meller
authors.forename: Roger P
authors.initials: RP
authors.lastname: Simon
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000235:genetics* / Q000628:therapy*; D023281:Genomics; D006801:Humans; D019194:Ischemic Preconditioning; D051379:Mice; D051381:Rats