title: [Recommendations for therapeutic monitoring of antidepressants].
abstract: Therapeutic drug monitoring (TDM), combined in certain situations with pharmacogenetic tests of metabolism, has proven a valuable tool for psychopharmacotherapy. Uncertain drug adherence, suboptimal tolerability, nonresponse at therapeutic doses, or pharmacokinetic drug-drug interactions are typical situations when measurement of medication concentrations is helpful. This article is an adaptation of guidelines recently issued by the AGNP-TDM group (Hiemke et al., www. agnp.de), but its content focuses mainly on the TDM of antidepressants. Finally, the potential benefits of TDM for optimization of pharmacotherapy can only be obtained if the method is adequately integrated into the clinical treatment process.
authors.affiliation: Département de psychiatrie Site de Cery, CHUV, Prilly-Lausanne. pierre.baumann@chuv.ch
authors.forename: P
authors.initials: P
authors.lastname: Baumann
authors.forename: M
authors.initials: M
authors.lastname: Rougemont
authors.forename: E
authors.initials: E
authors.lastname: Corruble
authors.forename: C
authors.initials: C
authors.lastname: Hiemke
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D055118:Medication Adherence; D010597:Pharmacogenetics; D017410:Practice Guidelines as Topic
chemical_list: D000928:Antidepressive Agents