title: [Development of sarcoidosis during treatment for chronic hepatitis C with pegylated interferon alfa-2a and ribavirin: case report and literature review].
abstract: Sarcoidosis is a chronic inflammatory multisystem disease of unknown aetiology. IFN-alfa is an immunomodulatory cytokine, currently used with ribavirin in the treatment of chronic hepatitis C infection. Due to its effects on the immune system, IFN-? may lead to the induction or exacerbation of autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and sarcoidosis. We report on a 37-year-old man, presenting with sarcoidosis during a six-month course of PEG-IFN alfa-2a and ribavirin for chronic hepatitis C virus genotype 3 infection.
authors.affiliation: Department of Clinical and Molecular Biomedicine, Division of Infectious Diseases, University of Catania, Italy. cacopardobruno@inwind.it
authors.forename: Bruno
authors.initials: B
authors.lastname: Cacopardo
authors.forename: Marilia Rita
authors.initials: MR
authors.lastname: Pinzone
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nunnari
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects*; D011241:Prednisone / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D012254:Ribavirin / Q000008:administration & dosage / Q000009:adverse effects*; D012507:Sarcoidosis / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000998:Antiviral Agents; D005938:Glucocorticoids; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a; D011241:Prednisone