title: Cellular FLICE-like inhibitory protein long form (c-FLIPL) overexpression is related to cervical cancer progression.
abstract: Cervical cancer is a leading cause of cancer deaths in women worldwide and infection by high-risk human papillomavirus types is a precursor event. The cellular FLICE-like inhibitory protein (c-FLIP) has been found to be overexpressed in several types of cancers and could be associated with cervical cancer progression because of its ability to inhibit the apoptotic process. To detect c-FLIP expression in cervical cancer, an immunohistochemical staining was performed, using tissue microarrays, on a series of 536 archival biopsy samples, including normal cervical tissues, low-grade and high-grade squamous intraepithelial lesions, and squamous cervical carcinomas. The epithelium in the normal cervix and low-grade squamous intraepithelial lesions mainly stained negatively for c-FLIP, whereas high-grade intraepithelial lesions and cancer samples showed an elevated expression of c-FLIP. A direct association was observed between the increasing grade of the lesion and the intensity of c-FLIP staining, in which the frequency of intense c-FLIP expression increased from 12.5% in the normal tissue to 82.1% in the cervical cancer tissue. An increased expression of c-FLIP may be an important factor in the progression of cervical cancer. This finding could aid in identifying patients with preneoplastic lesions at greater risk of developing cervical cancer. c-FLIP expression in cervical tissue may be a potential cervical cancer progression marker.
authors.affiliation: Molecular Pathology Laboratory, Department of Pathology, BIOREN-CEGIN, School of Medicine Universidad de La Frontera, Temuco, Chile.
authors.forename: Carmen Gloria
authors.initials: CG
authors.lastname: Ili
authors.forename: Priscilla
authors.initials: P
authors.lastname: Brebi
authors.forename: Oscar
authors.initials: O
authors.lastname: Tapia
authors.forename: Alejandra
authors.initials: A
authors.lastname: Sandoval
authors.forename: Jaime
authors.initials: J
authors.lastname: Lopez
authors.forename: Patricia
authors.initials: P
authors.lastname: Garcia
authors.forename: Pamela
authors.initials: P
authors.lastname: Leal
authors.forename: David
authors.initials: D
authors.lastname: Sidransky
authors.forename: Rafael
authors.initials: R
authors.lastname: Guerrero-Preston
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Roa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000032:analysis / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D046888:Tissue Array Analysis; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein