title: The treatment of heart failure in the 21st century: is the glass half empty or half full?
abstract: The field of heart failure has seen striking advances during the past 50 years, yet the overall economic and social burden imposed by heart failure continues to rise. While neurohormonal models provide many insights in terms of explaining disease progression and informing drug development, mounting clinical evidence suggests that this model provides only a partial explanation of the disease. This paper evaluates the emerging models of heart failure and their potential to reverse the disturbing trends in heart failure morbidity and mortality.
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Biykem
authors.initials: B
authors.lastname: Bozkurt
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Mann
mesh_terms: D000818:Animals; D002309:Cardiology / Q000639:trends*; D004059:Diffusion of Innovation; D005544:Forecasting; D006333:Heart Failure / Q000378:metabolism / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D049674:History, 21st Century; D006801:Humans; D057285:Precision Medicine / Q000639:trends*; D011379:Prognosis; D057170:Translational Research, Biomedical / Q000639:trends*
keywords: Winters Center for Heart Failure Research; acute decompensated HF; heart failure