title: [Incidence of chemotherapy-induced nausea and vomiting in patients receiving carboplatin-including chemotherapy].
abstract: The present study was designed to evaluate the incidence ofchemotherapy -induced nausea and vomiting(CINV)in patients receiving carboplatin. Chemo-naÏve patients with thoracic and gynecological malignancy, who were intended to be given carboplatin-including chemotherapy without aprepitant as antiemesis, were enrolled. CINV was assessed using a visual analog scale for a week after the final chemotherapy. Thirty-one patients were evaluated, and 6.5% and 48.4% of them developed vomiting and nausea after chemotherapy, respectively. Nausea in the delayed phase tended to be increased compared with that in the acute phase. The higher incidence of CINV was significantly correlated with younger ages(odds ratio= 0.355, 95% CI: 0.132-0.951, p=0.039). Our results indicate that further intensive antiemetic prophylaxis, such as using aprepitant or palonosetron, should be considered in patients receiving carboplatin.
authors.affiliation: Dept. of Nursing, Shinshu University Hospital, Japan.
authors.forename: Hanako
authors.initials: H
authors.lastname: Momose
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ide
authors.forename: Kazunari
authors.initials: K
authors.lastname: Tateishi
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016190:Carboplatin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced*; D009369:Neoplasms / Q000188:drug therapy; D014839:Vomiting / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin