title: Effects of high dose of anisodamine on the respiratory function of patients with traumatic acute lung injury.
abstract: The objective of this study is to observe the effects of high dose of anisodamine in the respiratory function of patients with acute lung injury (ALI) induced by trauma. Fifty cases of patients with complicated ALI after trauma were randomly divided into the anisodamine treatment group (n = 26) and the conventional treatment group (n = 24). Intravenous injection of high dose of anisodamine was administrated in the anisodamine treatment group on the basis of conventional treatment. Acute lung injury scores, oxygenation index, PaO2, respiratory mechanic index, mechanical ventilation time, and the occurrence of adverse reactions in the two groups were observed. Acute lung injury scores and respiratory parameters were all significantly improved in the two groups of patients after the treatment (P < 0.05); compared with the conventional treatment group, the improvements of respiratory function in the anisodamine treatment group were more obvious (P < 0.05), the mechanical ventilation time was shorter (P < 0.05), and there was no significant adverse reaction. In conclusion, high dose of anisodamine contributed to improve the respiratory function of the patients with traumatic ALI.
authors.affiliation: Department of Traumatology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan, 430030, Hubei, China. gszheng@tjh.tjmu.edu.cn
authors.forename: Zheng
authors.initials: Z
authors.lastname: Guoshou
authors.forename: Zhan
authors.initials: Z
authors.lastname: Chengye
authors.forename: Li
authors.initials: L
authors.lastname: Zhihui
authors.forename: Luo
authors.initials: L
authors.lastname: Jinlong
mesh_terms: D018806:APACHE; D055371:Acute Lung Injury / Q000188:drug therapy* / Q000209:etiology; D000328:Adult; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D012121:Respiration, Artificial; D015656:Respiratory Mechanics; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*; D014947:Wounds and Injuries / Q000150:complications
chemical_list: D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine