title: Modulation of the antibiotic activity by extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan.
abstract: The aim of this study was to verify the possible interactions between ethanol extracts of Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan, combined with six antimicrobial drugs against multiresistant strains of Staphylococcus aureus and Escherichia coli isolated from humans. The antibacterial activity of the extracts was determined using the minimum inhibitory concentration (MIC). The microdilution assay was performed to verify the interactions between the natural products and the antibiotics using a subinhibitory concentration. The activity of amikacin associated with the extract of Anadenanthera macrocarpa against EC 27 was enhanced, demonstrating an MIC reduction from 128 to 4  μg/mL. Among the β-lactams, no potentiation on its activity was observed, with exception to the antagonism of the natural products with ampicillin against S. aureus 358.
authors.affiliation: Faculdade Leão Sampaio, 63100-000, Juazeiro do Norte, CE, Brazil.
authors.forename: Fernando G
authors.initials: FG
authors.lastname: Figueredo
authors.forename: Emerson O
authors.initials: EO
authors.lastname: Ferreira
authors.forename: Bruno F F
authors.initials: BF
authors.lastname: Lucena
authors.forename: Cícero M G
authors.initials: CM
authors.lastname: Torres
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Lucetti
authors.forename: Elaine C P
authors.initials: EC
authors.lastname: Lucetti
authors.forename: João Marcos F L
authors.initials: JM
authors.lastname: Silva
authors.forename: Francisco A V
authors.initials: FA
authors.lastname: Santos
authors.forename: Cássio R
authors.initials: CR
authors.lastname: Medeiros
authors.forename: Gardênia M M
authors.initials: GM
authors.lastname: Oliveira
authors.forename: Aracélio V
authors.initials: AV
authors.lastname: Colares
authors.forename: José G M
authors.initials: JG
authors.lastname: Costa
authors.forename: Henrique D M
authors.initials: HD
authors.lastname: Coutinho
authors.forename: Irwin R A
authors.initials: IR
authors.lastname: Menezes
authors.forename: Júlio C F
authors.initials: JC
authors.lastname: Silva
authors.forename: Marta R
authors.initials: MR
authors.lastname: Kerntopf
authors.forename: Patrícia R L
authors.initials: PR
authors.lastname: Figueiredo
authors.forename: Edinardo F F
authors.initials: EF
authors.lastname: Matias
mesh_terms: D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D031298:Mimosa / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D047090:beta-Lactams; D000667:Ampicillin; D000583:Amikacin