title: Polysaccharides and their derivatives for versatile tissue engineering application.
abstract: Research and development in the design, synthesis, modification, evaluation, and characterization of polysaccharide-based bioactive polymeric materials for guiding and promoting new tissue in-growth is reviewed. Emphasis is given in this interdisciplinary field of tissue engineering (TE) with particular reference to bone, cartilage, and skin TE. Current strategies in scaffold-guided TE approaches using polymers of natural origin and their composites are elaborated. Innovative modification techniques in creating functional materials for advanced TE applications are presented. Challenges and possible solutions in the technological innovation in factor molecules incorporation and surface functionalization for improving the fabrication of biomaterials scaffolds for cost-effective TE are also presented.
authors.affiliation: School of Chemistry, The University of Edinburgh, West Mains Road, Kings Buildings, EH9 3JJ, UK. ferdous.khan0@gmail.com
authors.forename: Ferdous
authors.initials: F
authors.lastname: Khan
authors.forename: Sheikh Rafi
authors.initials: SR
authors.lastname: Ahmad
mesh_terms: D000464:Alginates / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D001842:Bone and Bones / Q000737:chemistry*; D002356:Cartilage / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry; D002686:Chitin / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D003432:Cross-Linking Reagents; D006820:Hyaluronic Acid / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D012867:Skin / Q000737:chemistry*; D013213:Starch / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D011134:Polysaccharides; D002686:Chitin; D002482:Cellulose; D006820:Hyaluronic Acid; D013213:Starch; D048271:Chitosan