title: Anti-inflammatory effects of ellagic acid on acute lung injury induced by acid in mice.
abstract: Acute lung injury (ALI) is characterized by alveolar edema and uncontrolled neutrophil migration to the lung, and no specific therapy is still available. Ellagic acid, a compound present in several fruits and medicinal plants, has shown anti-inflammatory activity in several experimental disease models. We used the nonlethal acid aspiration model of ALI in mice to determine whether preventive or therapeutic administration of ellagic acid (10 mg/kg; oral route) could interfere with the development or establishment of ALI inflammation. Dexamethasone (1 mg/kg; subcutaneous route) was used as a positive control. In both preventive and therapeutic treatments, ellagic acid reduced the vascular permeability changes and neutrophil recruitment to the bronchoalveolar lavage fluid (BALF) and to lung compared to the vehicle. In addition, the ellagic acid accelerated the resolution for lung neutrophilia. Moreover, ellagic acid reduced the COX-2-induced exacerbation of inflammation. These results were similar to the dexamethasone. However, while the anti-inflammatory effects of dexamethasone treatment were due to the reduced activation of NF- κ B and AP-1, the ellagic acid treatment led to reduced BALF levels of IL-6 and increased levels of IL-10. In addition, dexamethasone treatment reduced IL-1 β. Together, these findings identify ellagic acid as a potential therapeutic agent for ALI-associated inflammation.
authors.affiliation: Laboratório de ImunoFarmacologia Experimental (LIFE), Universidade Federal do Triângulo Mineiro (UFTM), Departamento de Clínica Médica, Instituto de Ciências da Saúde, Uberaba MG, Brazil.
authors.forename: Daniely
authors.initials: D
authors.lastname: Cornélio Favarin
authors.forename: Maxelle
authors.initials: M
authors.lastname: Martins Teixeira
authors.forename: Ednéia
authors.initials: E
authors.lastname: Lemos de Andrade
authors.forename: Claudiney
authors.initials: C
authors.lastname: de Freitas Alves
authors.forename: Javier Emilio
authors.initials: JE
authors.lastname: Lazo Chica
authors.forename: Carlos
authors.initials: C
authors.lastname: Artério Sorgi
authors.forename: Lúcia Helena
authors.initials: LH
authors.lastname: Faccioli
authors.forename: Alexandre
authors.initials: A
authors.lastname: Paula Rogerio
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004610:Ellagic Acid / Q000627:therapeutic use*; D005260:Female; D006851:Hydrochloric Acid / Q000633:toxicity*; D016753:Interleukin-10 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000893:Anti-Inflammatory Agents; D053583:Interleukin-1beta; D015850:Interleukin-6; D016753:Interleukin-10; D004610:Ellagic Acid; D006851:Hydrochloric Acid