title: The co-imaging of gamma camera measurements of aerosol deposition and respiratory anatomy.
abstract: The use of gamma camera imaging following the inhalation of a radiolabel has been widely used by researchers to investigate the fate of inhaled aerosols. The application of two-dimensional (2D) planar gamma scintigraphy and single-photon emission computed tomography (SPECT) to the study of inhaled aerosols is discussed in this review. Information on co-localized anatomy can be derived from other imaging techniques such as krypton ventilation scans and low- and high-resolution X-ray computed tomography (CT). Radionuclide imaging, combined with information on anatomy, is a potentially useful approach when the understanding of regional deposition within the lung is central to research objectives for following disease progression and for the evaluation of therapeutic intervention.
authors.affiliation: Faculty of Health Sciences, University of Southampton, Southampton, UK SO16 6YD. jhc@soton.ac.uk
authors.forename: Joy
authors.initials: J
authors.lastname: Conway
authors.forename: John
authors.initials: J
authors.lastname: Fleming
authors.forename: Michael
authors.initials: M
authors.lastname: Bennett
authors.forename: Tom
authors.initials: T
authors.lastname: Havelock
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D016503:Drug Delivery Systems; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism; D011877:Radionuclide Imaging / Q000379:methods*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D000336:Aerosols; D004364:Pharmaceutical Preparations