title: Molecularly imprinted SPE combined with dispersive liquid-liquid microextraction for selective analysis of telmisartan in biological and formulation samples.
abstract: BACKGROUND
  The present communication describes the combination of molecularly imprinted SPE and dispersive liquid-liquid microextraction for the selective preconcentration and determination of telmisartan (TEL) in rat urine, plasma and pharmaceutical formulation by HPLC.
  
  
  RESULTS
  Various factors that can affect the extraction efficiency of molecularly imprinted SPE and dispersive liquid-liquid microextraction were optimized. The LOD and LOQ were found to be 0.19 and 0.63 µg ml(-1) in urine, while in plasma it was found to be 0.28 and 0.87 µg ml(-1), respectively. The percentage recovery of TEL in different matrices was found to be in the range of 81-97%.
  
  
  CONCLUSIONS
  The proposed method may find wide applications in clinical, toxicological and QC laboratories for the routine analysis of TEL.
authors.affiliation: Analytical Chemistry Section, CSIR-Indian Institute of Toxicology Research, M G Marg, Lucknow, 226 001, UP, India. mohanitrc@gmail.com
authors.forename: Mohana Krishna Reddy
authors.initials: MK
authors.lastname: Mudiam
authors.forename: Abhishek
authors.initials: A
authors.lastname: Chauhan
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Singh
authors.forename: Vinod Praveen
authors.initials: VP
authors.lastname: Sharma
authors.forename: Prem Narain
authors.initials: PN
authors.lastname: Saxena
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000032:analysis*; D000818:Animals; D001562:Benzimidazoles / Q000032:analysis*; D001565:Benzoates / Q000032:analysis*; D059627:Liquid Phase Microextraction / Q000379:methods*; D008297:Male; D054802:Molecular Imprinting / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D052616:Solid Phase Extraction / Q000379:methods*; D000077333:Telmisartan
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D000077333:Telmisartan