title: Enantioselective tandem reaction of chromone-derived Morita-Baylis-Hillman carbonates with benzylamines catalyzed by a trifunctional organocatalyst: the synthesis of chiral 3-aminomethylene-flavanones.
abstract: An enantioselective tandem reaction of chromones-derived MBH carbonates (1) with benzylamines (2) catalyzed by a trifunctional organocatalyst, cinchonidine-amide-thiourea, has been developed in moderate to good yields (50-87%) and enantioselectivities (up to 89% ee).
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Neng-jun
authors.initials: NJ
authors.lastname: Zhong
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Chen
mesh_terms: D000577:Amides / Q000737:chemistry; D001596:Benzylamines / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D002384:Catalysis; D002867:Chromones / Q000737:chemistry; D002930:Cinchona Alkaloids / Q000737:chemistry; D044950:Flavanones / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
chemical_list: D000577:Amides; D001596:Benzylamines; D002254:Carbonates; D002867:Chromones; D002930:Cinchona Alkaloids; D044950:Flavanones; C041622:cinchonidine; D013890:Thiourea