title: Enhancers: five essential questions.
abstract: It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.
authors.affiliation: Genomics Division, One Cyclotron Road, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. lapennacchio@lbl.gov
authors.forename: Len A
authors.initials: LA
authors.lastname: Pennacchio
authors.forename: Wendy
authors.initials: W
authors.lastname: Bickmore
authors.forename: Ann
authors.initials: A
authors.lastname: Dean
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Nobrega
authors.forename: Gill
authors.initials: G
authors.lastname: Bejerano
mesh_terms: D004742:Enhancer Elements, Genetic / Q000235:genetics*; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009154:Mutation; D011401:Promoter Regions, Genetic / Q000235:genetics*