title: The Evangelismos hospital central nervous system tumor registry: Analysis of 1414 cases (1998-2009).
abstract: BACKGROUND
  The Evangelismos Hospital central nervous system (CNS) Tumor Registry represents the current effort of the Departments of Neurosurgery and Pathology to collect data for primary and metastatic CNS tumor patients. In the present study, 12-year hospital data (1998-2009) were reviewed and analyzed.
  
  
  METHODS
  Patients that underwent surgery for CNS tumors for the first time were identified. Histologically confirmed tumor rates by age and gender were compared. Time trends in annual rates for specific tumor types were investigated. In-hospital mortality rates and length of hospital stay were analyzed by age and gender and their putative variations across the study period investigated.
  
  
  RESULTS
  A total of 1414 patients (age 15-89 years) were identified. The most frequently encountered histologies were gliomas and meningiomas, accounting for, respectively, 32.8% and 29.1% of the total sample. A greater proportion of meningiomas was found in women; the proportion of glioblastomas and metastatic tumors, as well as of mixed gliomas, were greater in men. Increased rates of glioblastoma and meningioma with advancing age at diagnosis were also apparent. There were no significant variations in time trends for specific tumor types. In-hospital mortality was significantly higher for older patients (≥70 years). An increase in the length of hospital stay was apparent between the first and middle third of the study period.
  
  
  CONCLUSIONS
  Analysis of tumor rates in relation to age at diagnosis and gender showed significant bias in accordance with salient literature. Available data indicated no significant variations in time trends for specific tumor types across the study period, while an adverse effect of advanced age on in-hospital mortality was shown. The present findings can guide the formulation of future treatment programs and preventive strategies and provide the basis for further intra- and/or interdepartmental research.
authors.affiliation: Department of Neurosurgery, University of Athens, Evangelismos Hospital, Athens, Greece ; Hellenic Center of Neurosurgical Research (HCNR), "Professor Petros S. Kokkalis", Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Stranjalis
authors.forename: Theodosis
authors.initials: T
authors.lastname: Kalamatianos
authors.forename: Lampis C
authors.initials: LC
authors.lastname: Stavrinou
authors.forename: Dimitris
authors.initials: D
authors.lastname: Mathios
authors.forename: Christos
authors.initials: C
authors.lastname: Koutsarnakis
authors.forename: Chara
authors.initials: C
authors.lastname: Tzavara
authors.forename: Maria
authors.initials: M
authors.lastname: Loufardaki
authors.forename: Despina
authors.initials: D
authors.lastname: Protopappa
authors.forename: Theodore
authors.initials: T
authors.lastname: Argyrakos
authors.forename: Dimitra P
authors.initials: DP
authors.lastname: Rontogianni
authors.forename: Damianos E
authors.initials: DE
authors.lastname: Sakas
keywords: Central nervous system tumors; hospital-based tumor registry; length of hospital stay; mortality; surgical mortality