title: [The combined therapy with valdoxan and amitriptyline of treatment resistant somatized depression].
abstract: The combined treatment with valdoxan and amitriptyline has been suggested as one of the possible variants to overcome treatment resistance in somatized depression. A study design was based on the rhythmological model of depression which clinically characterized by altered sleep-awakeness cycles. According to this notion, 36 patients were divided into two groups by the presence (20 patients) or absence (16 patients) of severe sleep disorders. The combined treatment was more effective in the first group of patients with insomnia which was an indicator of altered sleep-awakeness cycles.
authors.forename: V S
authors.initials: VS
authors.lastname: Sobennikov
authors.forename: M L
authors.initials: ML
authors.lastname: Prokop'eva
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D061218:Depressive Disorder, Treatment-Resistant / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008550:Melatonin / Q000819:agonists; D008875:Middle Aged; D012890:Sleep / Q000502:physiology; D016896:Treatment Outcome; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000639:Amitriptyline; D000929:Antidepressive Agents, Tricyclic; D006993:Hypnotics and Sedatives; D008550:Melatonin; C084711:agomelatine; D009281:Naphthalenes