title: Gene loops and HDACs to promote transcription directionality.
abstract: Gene loops have been described in different organisms from yeast to human and form through interaction between components of the transcription pre-initiation complex and Ssu72, a member of the 3' end cleavage and polyadenylation complex. A recent study by Tan-Wong et al. reports a new role for gene loops in promoting ORF transcription directionality from otherwise bidirectional promoters.
authors.affiliation: Department of Cell Biology, NCCR Frontiers in Genetics, iGE3 and University of Geneva, Geneva, Switzerland.
authors.forename: Manuele
authors.initials: M
authors.lastname: Castelnuovo
authors.forename: Françoise
authors.initials: F
authors.lastname: Stutz
mesh_terms: D000107:Acetylation; D006655:Histone Deacetylases / Q000235:genetics* / Q000378:metabolism; D006657:Histones / Q000235:genetics; D006801:Humans; D011401:Promoter Regions, Genetic; D012313:RNA / Q000235:genetics*; D014158:Transcription, Genetic; D015003:Yeasts / Q000235:genetics
chemical_list: D006657:Histones; D012313:RNA; D006655:Histone Deacetylases
keywords: antisense RNA; bidirectional promoters; gene loop; histone deacetylase; non-coding RNA