title: Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
abstract: Bioassay-guided fractionation of the CHCl3 layer of Solanum violaceum areal parts methanolic extract led to the isolation of four new steroidal sapogenins, indiosides L-O (1-4), along with eight known steroids, one lignin, and a coumarin. Indioside L is a rare spirostanoid possessing a 1,4-dien-3-one moiety in ring A. Moreover, compounds 3 and 4 represent rare examples of spirostene with the 3β,7α-diol-5,6-ene moiety compared to the normal 3β,7β-diol-5,6-ene derivatives. The cytotoxic activity of the isolates (5-14) was evaluated against human hepatoma (HepG2 and Hep3B), human lung carcinoma (A549), and human breast carcinoma (MDA-MB-231 and MCF-7).
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Chiao-Ting
authors.initials: CT
authors.lastname: Yen
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Shazly
authors.forename: Cheng-Ying
authors.initials: CY
authors.lastname: Yu
authors.forename: Ming-Hong
authors.initials: MH
authors.lastname: Yen
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Chen
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D032322:Solanum / Q000737:chemistry*; D013150:Spirostans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D013150:Spirostans