title: Microwave-assisted three-component domino reaction: Synthesis of indolodiazepinotriazoles.
abstract: A microwave-assisted three-component protocol involving N-1 alkylation of 2-alkynylindoles with epichlorohydrin, ring opening of the epoxide with sodium azide, and an intramolecular Huisgen azide-internal alkyne 1,3-dipolar cycloaddition domino sequence has been described. The efficacy of the methodology has been demonstrated by treating various 2-alkynylindoles (aromatic/aliphatic) with epichlorohydrin and sodium azide furnishing annulated tetracyclic indolodiazepinotriazoles in satisfactory yields.
authors.affiliation: Medicinal & Process Chemistry Division CSIR-Central Drug Research Institute, Lucknow-226001, India.
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Arigela
authors.forename: Sudhir K
authors.initials: SK
authors.lastname: Sharma
authors.forename: Brijesh
authors.initials: B
authors.lastname: Kumar
authors.forename: Bijoy
authors.initials: B
authors.lastname: Kundu
keywords: 1,3-dipolar cycloaddition; 2-alkynylindoles; azides; domino reaction; indolodiazepinotriazoles