title: [Clinical and experimental research of immunomodulatory effect of amisulpride].
abstract: Study of immunomodulatory effect of atypical antipsychotic amisulpride has revealed a positive clinical effect after 6-week therapy of schizophrenic patients regarding both positive and negative symptoms. A decrease in activity of humoral immunity factors (B lymphocytes, immunoglobulins, HLADR(+)-cells) identified among schizophrenic patients in the process of amisulpride therapy can be attributed to a positive effect optimizing the ratio Th1/Th2. Amisulpride when used under experimental conditions produced a suppression of IgM-immune response in mice of the C57BL/6J strain. This effect was more expressed in animals with aggressive behavior pattern.
authors.forename: T P
authors.initials: TP
authors.lastname: Vetlugina
authors.forename: O A
authors.initials: OA
authors.lastname: Lobacheva
authors.forename: E L
authors.initials: EL
authors.lastname: Al'perina
authors.forename: E N
authors.initials: EN
authors.lastname: Zhukova
authors.forename: A V
authors.initials: AV
authors.lastname: Semke
authors.forename: V B
authors.initials: VB
authors.lastname: Nikitina
authors.forename: M A
authors.initials: MA
authors.lastname: Cheĭdo
authors.forename: G V
authors.initials: GV
authors.lastname: Idova
mesh_terms: D000328:Adult; D000077582:Amisulpride; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D056724:Immunity, Humoral / Q000187:drug effects*; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012559:Schizophrenia / Q000188:drug therapy* / Q000276:immunology; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000888:Antibodies, Anti-Idiotypic; D014150:Antipsychotic Agents; D007075:Immunoglobulin M; D013469:Sulpiride; D000077582:Amisulpride