title: Effect of a low dose of gonadotropin releasing hormone antagonist on in vitro fertilization outcomes.
abstract: OBJECTIVE
  This study aims to determine whether a low dose of the gonadotropin releasing hormone antagonist, cetrorelix, prevents a premature luteinizing hormone (LH) surge and affects in vitro fertilization (IVF) outcomes compared to the standard dose of 0.25 mg/day.
  
  
  METHODS
  In this study, 45 IVF/intracytoplasmic sperm injection patients were stimulated with recombinant follicle stimulation hormone from day 2 of the cycle. Cetrorelix was injected daily from day 6 of gonadotropin administration. Twenty-two patients received cetrorelix at a dose of 0.25 mg/day, whereas 23 participants received half dose.
  
  
  RESULTS
  The mean consumption of gonadotropins was significantly higher in patients receiving 0.25 mg/day of cetrorelix (2,213 vs. 1,350 U; p = 0.046). The clinical pregnancy rates were similar in both groups (31.8 vs. 47.8 %; p = 0.273). Premature LH surge was detected in 9.1 % of the patients receiving cetrorelix 0.25 mg/day and in 13 % of the patients receiving cetrorelix 0.125 mg/day (p > 0.05). The difference between two groups was not statistically significant (p > 0.05).
  
  
  CONCLUSIONS
  Our results suggest that there is no difference between a cetrorelix dose of 0.125 or 0.25 mg/day in preventing premature LH rise during ovarian stimulation for IVF.
authors.affiliation: Department of Obstetrics and Gynecology, Selçuk University Medicine Faculty, Konya, Turkey. ozlemsecilmis@hotmail.com
authors.forename: Ozlem Seçilmiş
authors.initials: OS
authors.lastname: Kerimoğlu
authors.forename: Cihangir Mutlu
authors.initials: CM
authors.lastname: Ercan
authors.forename: Uğur
authors.initials: U
authors.lastname: Keskin
authors.forename: Cem
authors.initials: C
authors.lastname: Korkmaz
authors.forename: Namık Kemal
authors.initials: NK
authors.lastname: Duru
authors.forename: Ali
authors.initials: A
authors.lastname: Ergün
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; C062876:cetrorelix