title: Clinical MRI for iron detection in Parkinson's disease.
abstract: We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R2* was able to reflect symptoms of PD. In addition, the clinically used susceptibility-weighted imaging differentiated between controls and patients, whereas T2-weighted imaging did not. Disease-related changes were present not only in substantia nigra but also in globus pallidus. Such changes are associated with neurodegeneration, reflecting the severity of motor impairment.
authors.affiliation: Medical Imaging Centre, Department of Radiology, Tampere University Hospital, Tampere, Finland. maija.rossi@pshp.fi
authors.forename: Maija
authors.initials: M
authors.lastname: Rossi
authors.forename: Hanna
authors.initials: H
authors.lastname: Ruottinen
authors.forename: Seppo
authors.initials: S
authors.lastname: Soimakallio
authors.forename: Irina
authors.initials: I
authors.lastname: Elovaara
authors.forename: Prasun
authors.initials: P
authors.lastname: Dastidar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping / Q000379:methods; D002421:Caudate Nucleus / Q000737:chemistry / Q000473:pathology; D003337:Corpus Callosum / Q000737:chemistry / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005917:Globus Pallidus / Q000737:chemistry* / Q000473:pathology*; D006801:Humans; D007501:Iron / Q000032:analysis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis*; D013378:Substantia Nigra / Q000737:chemistry* / Q000473:pathology*
chemical_list: D007501:Iron