title: Increased collagen synthesis rate during wound healing in muscle.
abstract: Wound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical incision. Collagen synthesis rate was increased by 480% and 860% on days 2 and 7 respectively after surgery in the wounded muscle compared with an undamaged area of the same muscle. Collagen content was increased by approximately 100% at both day 2 and day 7. These results demonstrate that collagen deposition during wound healing in muscle is achieved entirely by an increase in the rate of collagen synthesis.
authors.affiliation: Diabetes and Nutritional Sciences Division, King's College London, London, United Kingdom.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Zhou
authors.forename: Jonathan
authors.initials: J
authors.lastname: Salisbury
authors.forename: Victor R
authors.initials: VR
authors.lastname: Preedy
authors.forename: Peter W
authors.initials: PW
authors.lastname: Emery
mesh_terms: D000009:Abdominal Muscles / Q000293:injuries* / Q000503:physiopathology*; D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D007700:Kinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000502:physiology*
chemical_list: D003094:Collagen