title: Aortic wall thickness and amniotic fluid albuminuria in growth-restricted twin fetuses.
abstract: OBJECTIVE
  Intrauterine growth restriction (IUGR) may be associated with significantly higher aortic intima-media thickening (aIMT) values. It is unknown if fetal aIMT is associated with glomerulosclerosis and amniotic albuminuria in utero.
  
  
  METHODS
  Fetal abdominal aIMT and amniotic albumin/creatinine ratio (ACR) were measured in 126 individual twin fetuses, recruited by the Obstetrics and Gynaecology Clinics of the University of Padua (Italy) Medical Center. The IUGR twin fetuses were classified into two groups: Group A were those fetuses whose estimated fetal weight (EFW) was <10th percentile with pulsatility index >2 SD and Group B were those fetuses whose EFW was <10th percentile and had no velocimetry abnormalities.
  
  
  RESULTS
  The median fetal aIMT was significantly different in the three groups (Group A = 0.9 mm; Group B = 0.7 mm; and appropriate for gestational age (AGA) = 0.5 mm; p < .0001). It was significantly higher in Group A than in the AGA group (p < .0001) and than in the Group B fetuses (p = .003), respectively. In addition, ACR was different in the three groups (Group A = 183,500 mg/g; Group B = 6,4720 mg/g; and AGA = 8,2750 mg/g; p = .0002). It was significantly higher in Group A than in the AGA group (p = .03) and than in Group B (p = .02), respectively.
  
  
  CONCLUSIONS
  Growth-restricted twin fetuses with velocimetry abnormalities present are associated with aIMT and higher ACR levels in amniotic fluid, which could be possible markers in utero of preclinical atherosclerosis, and early glomerulosclerosis.
authors.affiliation: Department of Pediatrics, University of Padua School of Medicine, Padua, Italy. zanardo@pediatria.unipd.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Zanardo
authors.forename: Silvia
authors.initials: S
authors.lastname: Visentin
authors.forename: Martina
authors.initials: M
authors.lastname: Bertin
authors.forename: Martina
authors.initials: M
authors.lastname: Zaninotto
authors.forename: Daniele
authors.initials: D
authors.lastname: Trevisanuto
authors.forename: Francesco
authors.initials: F
authors.lastname: Cavallin
authors.forename: Erich
authors.initials: E
authors.lastname: Cosmi
mesh_terms: D000419:Albuminuria / Q000000981:diagnostic imaging*; D000653:Amniotic Fluid / Q000000981:diagnostic imaging*; D001011:Aorta / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D018709:Statistics, Nonparametric; D017539:Tunica Intima / Q000000981:diagnostic imaging* / Q000473:pathology; D017540:Tunica Media / Q000000981:diagnostic imaging* / Q000473:pathology; D016216:Ultrasonography, Prenatal