title: [Meta-analysis of randomized trials of antimicrobial drugs in the treatment of coronary heart disease].
abstract: The meta-analysis of 12 clinical research of application of antibiotics (azithromycin, roxithromycin clarithromycin, gatifloxacin) in 24 949 patients with coronary heart disease were carried out. The obtained results were shown that application of short courses of antibiotic therapy in patients with severe morphological changes in small coronary vessels were not enough effective. Contrariwise, long-term courses of antibiotic therapy could be effective in patients with initial lesions of blood vessels and presence of chronic infections.
authors.forename: O V
authors.initials: OV
authors.lastname: Skochko
authors.forename: I P
authors.initials: IP
authors.lastname: Kaĭdashev
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017963:Azithromycin / Q000494:pharmacology / Q000627:therapeutic use*; D023521:Chlamydophila Infections / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D016993:Chlamydophila pneumoniae / Q000187:drug effects / Q000254:growth & development; D017291:Clarithromycin / Q000494:pharmacology / Q000627:therapeutic use*; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology / Q000627:therapeutic use*; D000077734:Gatifloxacin; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D016480:Helicobacter pylori / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D008297:Male; D010919:Placebos; D015575:Roxithromycin / Q000494:pharmacology / Q000627:therapeutic use*; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D010919:Placebos; D015575:Roxithromycin; D017963:Azithromycin; D017291:Clarithromycin; D000077734:Gatifloxacin