title: Flexizyme-mediated genetic reprogramming as a tool for noncanonical peptide synthesis and drug discovery.
abstract: Noncanonical peptides occur frequently in Nature, and often display high bioactivity. However, the lack of tractable systems for the synthesis of diverse libraries of such peptides has thus far hampered their development as drugs. Genetic reprogramming techniques, in which noncanonical amino acids may be incorporated into peptides, have largely removed this limitation. This Concept article outlines the development of these techniques with an emphasis on drug discovery.
authors.affiliation: Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Toby
authors.initials: T
authors.lastname: Passioura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Suga
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D015195:Drug Design; D055808:Drug Discovery; D015394:Molecular Structure; D010452:Peptide Biosynthesis; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D010456:Peptides, Cyclic; D016337:RNA, Catalytic