title: Biological evaluation of materials for cardiovascular application: the role of the short-term inflammatory response in endothelial regeneration.
abstract: Because of their suitable bio-mechanical properties, polymeric materials, such as Poly(L-lactic acid) (PLLA), and poly (lactic-co-glycolic acid) (PLGA), are often used in the biomedical field, in particular for cardiovascular applications. Implanted materials induce several events related to the inflammatory reaction, such as macrophage adhesion and activation with following cytokine release. This work considered the effect of macrophage adhesion and related cytokine release on endothelial cells (PAOEC) proliferation and migration. Slight differences have been shown by the macrophages reaction when in contact with PLLA, PLGA, or PLLA/PLGA blend. However, these differences showed to differently enhance endothelial cells behavior in terms of wound healing. These data suggest the inflammatory reaction as a useful way to consider concerning materials biocompatibility, in order to optimize the endothelial regeneration following vascular prosthetic implants.
authors.affiliation: Department of Health Sciences, University of Piemonte Orientale "A. Avogadro," 28100 Novara, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Boccafoschi
authors.forename: C
authors.initials: C
authors.lastname: Mosca
authors.forename: M
authors.initials: M
authors.lastname: Ramella
authors.forename: I
authors.initials: I
authors.lastname: Carmagnola
authors.forename: V
authors.initials: V
authors.lastname: Chiono
authors.forename: G
authors.initials: G
authors.lastname: Ciardelli
authors.forename: M
authors.initials: M
authors.lastname: Cannas
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D017077:Culture Media, Conditioned / Q000494:pharmacology; D016207:Cytokines / Q000096:biosynthesis; D042783:Endothelial Cells / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D004789:Enzyme Activation / Q000187:drug effects; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D019344:Lactic Acid / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D011100:Polyglycolic Acid / Q000494:pharmacology; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012038:Regeneration; D015398:Signal Transduction / Q000187:drug effects; D034421:Sus scrofa; D014945:Wound Healing / Q000187:drug effects; D020830:rac1 GTP-Binding Protein / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D017077:Culture Media, Conditioned; D016207:Cytokines; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D048049:Extracellular Signal-Regulated MAP Kinases; D020830:rac1 GTP-Binding Protein; D020741:rho GTP-Binding Proteins
keywords: PLGA; PLLA; cytokines; endothelial regeneration; wound healing