title: Reduced sevoflurane loss during cardiopulmonary bypass when using a polymethylpentane versus a polypropylene oxygenator.
abstract: OBJECTIVE
  The goal of this investigation was to examine the influence of two oxygenators with different membranes, made of either polypropylene (PPL) or polymethylpentane (PMP), on the plasma concentration of sevoflurane during cardiopulmonary bypass.
  
  
  METHODS
  The concentrations of sevoflurane during cardiopulmonary bypass were examined in patient plasma, endotracheal tubes, cardiotomy reservoirs and the outlets of the heart-lung oxygenators in twenty patients who underwent elective heart surgery.
  
  
  RESULTS
  The sevoflurane losses are smaller in cardiopulmonary bypass when using a polymethylpentane versus a polypropylene oxygenator. Ten minutes after beginning cardiopulmonary bypass, the sevoflurane plasma concentration in the PPL oxygenator group compared to the PMP oxygenator group fell significantly (PPL 0.48-1.79 (0.93) vs. PMP 0.80-2.15 (1.56) µL × 100 mL-1, p = 0.02). This difference persisted until ten minutes after the termination of cardiopulmonary bypass.
  
  
  CONCLUSIONS
  The results of this study show that using a polymethylpentane membrane oxygenator rather than a polypropylene oxygenator significantly reduces the losses of sevoflurane, resulting in higher plasma concentrations and greater depth of anesthesia.
authors.affiliation: Department of Anesthesiology, Emergency Medicine and Intensive Care, Georg-August-University of Göttingen, Göttingen, Germany. mail@josehinz.de
authors.forename: Jose
authors.initials: J
authors.lastname: Hinz
authors.forename: Jan Martin
authors.initials: JM
authors.lastname: Molder
authors.forename: Gerd-Gunnar
authors.initials: GG
authors.lastname: Hanekop
authors.forename: Andreas
authors.initials: A
authors.lastname: Weyland
authors.forename: Aron-Frederik
authors.initials: AF
authors.lastname: Popov
authors.forename: Martin
authors.initials: M
authors.lastname: Bauer
authors.forename: Stephan
authors.initials: S
authors.lastname: Kazmaier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018685:Anesthetics, Inhalation / Q000097:blood* / Q000493:pharmacokinetics; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D003243:Consciousness / Q000187:drug effects; D056805:Consciousness Monitors; D017558:Elective Surgical Procedures; D004569:Electroencephalography; D004867:Equipment Design; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000097:blood* / Q000493:pharmacokinetics; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000295:instrumentation / Q000379:methods; D010107:Oxygenators, Membrane; D011108:Polymers / Q000737:chemistry*; D011126:Polypropylenes / Q000737:chemistry*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D011108:Polymers; D011126:Polypropylenes; D000077149:Sevoflurane