title: Anterior gradient 2: a new target to treat colorectal cancer.
abstract: Colorectal cancer is one of the leading causes of cancer-associated morbidity and mortality across the world. Every year many patients died from the advanced colorectal cancer. We had tried our best to stop the progress by the chemotherapy and radiotherapy, but the process has not stopped. And we just can use the target drug to extend the survival time of the patient who is in advanced stage. It is said that the circulating tumor cells, distributed in the peripheral blood, is the initial material leading to metastases formation. And Anterior gradient 2 is a biomarker of these cells. It shows an enormous role in the process of cancer's occurrence, development and metastasis. It may be a useful target for us to prevent colorectal cancer from progress. And it may be a new way to treat the colorectal cancer.
authors.affiliation: Department of Gastrointestinal Surgery, First Teaching Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Gao
authors.forename: Xincai
authors.initials: X
authors.lastname: Xu
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Wenbin
authors.initials: W
authors.lastname: Zhang
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Geng
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D016503:Drug Delivery Systems; D006801:Humans; D008954:Models, Biological; D009088:Mucoproteins; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009360:Neoplastic Cells, Circulating / Q000378:metabolism*; D015513:Oncogene Proteins; D011506:Proteins / Q000378:metabolism*
chemical_list: C502296:AGR2 protein, human; D014408:Biomarkers, Tumor; D009088:Mucoproteins; D015513:Oncogene Proteins; D011506:Proteins