title: Coexistence of placental site nodule and cervical squamous carcinoma in a 72-year-old woman.
abstract: We report a unique case of the coexistence of cervical cancer and placental site nodule (PSN) in a 72-year-old multiparous woman presenting with vaginal bleeding. She had undergone tubal sterilization 30 years before. On admission, she had profuse vaginal bleeding, and a bulky cervical mass was seen on vaginal examination. Histology revealed the coexistence of a moderately differentiated invasive squamous cell carcinoma with a PSN in its stroma. Its immunohistochemistry revealed characteristic phenotypes for both lesions--the squamous carcinoma was strongly positive for p16. The intermediate trophoblasts of the PSN showed a diffuse positivity for CAM 5.2, human placental lactogen, CD10, and α-inhibin and, focally, for human chorionic gonadotropin. This is the first report on the coexistence of these 2 lesions in an elderly postmenopausal patient and demonstrates that PSN can be found after the menopause as an unexpected lesion in this age group, mimicking various cervical malignancies.
authors.affiliation: Department of Pathology, Universidad Nacional Autónoma de Nicaragua, León (UNAN-León), Granada, Spain. darling.valverde@unanleon.edu.ni
authors.forename: Darling Valverde
authors.initials: DV
authors.lastname: Luna
authors.forename: Isabel
authors.initials: I
authors.lastname: Dulcey
authors.forename: Francisco F
authors.initials: FF
authors.lastname: Nogales
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D014327:Trophoblasts / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*