title: Assessment of anti-inflammatory, lipid peroxidation and acute toxicity of extracts obtained from wild higher basidiomycetes mushrooms collected from Akure (southwest Nigeria).
abstract: Ethanolic extracts of three wild medicinal mushrooms, namely Lenzites betulina (LET), Trametes versicolor (TET), and Coriolopsis polyzona (CET), collected from Akure, southwest Nigeria, were assessed for their lipid peroxidation, anti-inflammatory, and acute toxicity effects. The inhibition of the formation of thiobarbituric acid reactive species (TBARS) by extracts was concentration dependent and ranged from 86.99% to 92.18% at 1000 µg/ mL. The IC50 of the extracts was also in the range of 222.81 µg/mL to 737.13 µg/mL. The anti-inflammatory effect measured by inhibition of mice ear edema was higher and significantly different (P ≤ 0.05) than the control. The acute toxicity test also revealed tolerance to the three ethanolic extracts by Artemia salina at concentrations of 10 µg/mL to 1000 µg/mL, except for ethanolic extracts of LET and TET, which exhibited toxicity against this invertebrate at 1000 µg/mL. This research has shown that ethanolic extracts of these three macrofungi could be good sources of safe and effective antioxidant and antinflammatory agents for biopharmaceutical exploitation.
authors.affiliation: Department of Microbiology, Federal University of Technology, Akure, Nigeria. ovofuta@yahoo.com
authors.forename: Victor O
authors.initials: VO
authors.lastname: Oyetayo
authors.forename: Antonio
authors.initials: A
authors.lastname: Nieto-Camacho
authors.forename: Baldomero Esquivel
authors.initials: BE
authors.lastname: Rodriguez
authors.forename: Manuel
authors.initials: M
authors.lastname: Jimenez
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D001487:Basidiomycota / Q000737:chemistry*; D001681:Biological Assay; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D009288:Naproxen / Q000494:pharmacology; D009549:Nigeria; D051381:Rats; D017392:Thiobarbituric Acid Reactive Substances
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D017392:Thiobarbituric Acid Reactive Substances; D009288:Naproxen