title: The role of myeloperoxidase and myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCAs) in the pathogenesis of human MPO-ANCA-associated glomerulonephritis.
abstract: It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis. We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis. Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.
authors.affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan. arimuray@ks.jkyorin-u.ac.jp.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Arimura
authors.affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
authors.forename: Soko
authors.initials: S
authors.lastname: Kawashima
authors.affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Yoshihara
authors.affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Komagata
authors.affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kaname
authors.affiliation: First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yamada
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000628:therapy; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D002196:Capillaries / Q000276:immunology* / Q000473:pathology; D016207:Cytokines / Q000097:blood; D005921:Glomerulonephritis / Q000097:blood / Q000201:enzymology / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply*; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology*; D009195:Peroxidase / Q000276:immunology*; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D016207:Cytokines; D009195:Peroxidase