title: Effects of dietary conjugated linoleic acid and biopolymer encapsulation on lipid metabolism in mice.
abstract: Forty mice were randomly divided into four groups on the basis of the diet to be fed as follows: 5% (low) fat diet (T1: LF); 20% (high) fat diet (T2: HF); 20% fat containing 1% conjugated linoleic acid (CLA) (T3: HFC); and 20% fat containing 1% CLA with 0.5% biopolymers (T4: HFCB). The high-fat with CLA diet groups (HFC and HFCB) and the low-fat diet group (LF) tended to have lower body weights and total adipose tissue weights than those of the high-fat diet group (HF). Serum leptin and triglyceride were significantly lower in the high fat with CLA-fed groups (HFC and HFCB) and the low-fat diet group (LF) than those in the high-fat diet group (HF). It is noteworthy that the high-fat with CLA and biopolymers group (HFCB) showed the lowest serum triglyceride and cholesterol concentrations. In the high-fat-fed group (HF), voluntary travel distance as a measure of physical activity decreased after three weeks of feeding. However, the CLA-fed groups showed increased physical activity. The groups fed high-fat diets supplemented with CLA alone and with CLA and biopolymers had higher viscosity of small intestinal contents than that in the low- and high-fat dietary groups.
authors.affiliation: Department of Bioresources and Food Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Korea. lesikyung@konkuk.ac.kr.
authors.forename: Sun Jin
authors.initials: SJ
authors.lastname: Hur
authors.forename: Doo Hwan
authors.initials: DH
authors.lastname: Kim
authors.forename: Se Chul
authors.initials: SC
authors.lastname: Chun
authors.forename: Si Kyung
authors.initials: SK
authors.lastname: Lee
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects; D000818:Animals; D001704:Biopolymers / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008813:Mice, Inbred ICR; D018613:Microscopy, Confocal; D009929:Organ Size / Q000187:drug effects; D014783:Viscosity / Q000187:drug effects
chemical_list: D001704:Biopolymers; D004041:Dietary Fats; D044243:Linoleic Acids, Conjugated