title: Facile fabrication of multistimuli-responsive metallo-supramolecular core cross-linked block copolymer micelles.
abstract: Metallo-supramolecular core cross-linked (CCL) micelles are fabricated from terpyridine-functionalized double hydrophilic block copolymers, poly(2-(2-methoxyethoxy)ethyl methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate-co-4'-(6-methacryloxyhexyloxy)-2,2':6',2″-terpyridine) [PMEO2 MA-b-P(DEA-co-TPHMA)] via the formation of bis(terpyridine)ruthenium(II) complexes. These metallo-supramolecular CCL micelles exhibit not only high structural integrity under different pH values and temperatures in aqueous solution, but multistimuli responsiveness including pH-responsive cores, thermo-responsive shells, and reversible dissociation of bis(terpyridine)ruthenium(II) complexes upon addition of competitive metal ion chelator, which allows for precisely controlled release of the encapsulated hydrophobic guest molecules via the combination of different stimuli.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China Hefei, Anhui 230026, P. R. China. gezs@ustc.edu.cn
authors.forename: Zhishen
authors.initials: Z
authors.lastname: Ge
authors.forename: Shiyong
authors.initials: S
authors.lastname: Liu
mesh_terms: D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D017975:Ruthenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature
chemical_list: D008823:Micelles; D011108:Polymers; D017975:Ruthenium Compounds; D012428:Ruthenium