title: The reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications.
abstract: The reactions of three α-oxoaldehydes (methylglyoxal, glyoxal, and pyruvic acid) with hydroxyl radicals generated by sonolysis of water were investigated using an electron spin resonance (electron paramagnetic resonance) spin-trapping method, and their reaction kinetics were investigated. It is apparent from our experimental results that methylglyoxal exhibits the highest reactivity of the three α-oxoaldehydes. These α-oxoaldehydes can react with hydroxyl radicals faster than other well-known antioxidants can. The reactivity of hydroxyl radicals is higher than that of hydrogen peroxides.
authors.affiliation: Department of Bioengineering, Graduate School of Bioscience and Biochemistry, Tokyo Institute of Technology, 4259-G1-25, Nagatsuda-cho, Midori-ku, Yokohama 226-8502, Japan.
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Atsuo
authors.initials: A
authors.lastname: Iwasawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kamachi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ozawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kohno
keywords: ESR; glucose metabolites; hydroxyl radical; reactive oxygen species; α-oxoaldehyde