title: Two new tirucallane triterpenoids from the leaves of Aquilaria sinensis.
abstract: Two new tirucallane triterpenoids, aquilacallanes A-B (1-2), together with 15 known compounds (3-17) were isolated from the leaves of Aquilaria sinensis. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analyses. All compounds were evaluated for their cytotoxic activity against five human cancer cell lines. The known compounds, ursolic acid (7) and 5,7,4'-trimethoxyflavone (14), exhibited weak cytotoxic activity against some cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, People's Republic of China.
authors.forename: Jin Tang
authors.initials: JT
authors.lastname: Cheng
authors.forename: Ya Qiong
authors.initials: YQ
authors.lastname: Han
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Xing
authors.initials: X
authors.lastname: De Wu
authors.forename: Liao Bin
authors.initials: LB
authors.lastname: Dong
authors.forename: Li Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Qin Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002681:China; D002851:Chromatography, High Pressure Liquid; D055808:Drug Discovery; D020834:Ethnopharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D029645:Thymelaeaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes