title: Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues.
abstract: Methamphetamine (METH) is a potent and highly addictive central nervous system (CNS) stimulant. Additionally, METH adversely impacts immunological responses, which might contribute to the higher rate and more rapid progression of certain infections in drug abusers. However no studies have shown the impact of METH on inflammation within specific organs, cellular participation and cytokine production. Using a murine model of METH administration, we demonstrated that METH modifies, with variable degrees, leukocyte recruitment and alters cellular mediators in the lungs, liver, spleen and kidneys of mice. Our findings demonstrate the pleotropic effects of METH on the immune response within diverse tissues. These alterations have profound implications on tissue homeostasis and the capacity of the host to respond to diverse insults, including invading pathogens.
authors.affiliation: Department of Biomedical Sciences, Long Island University-Post, Brookville, NY, USA.
authors.forename: Habibullah
authors.initials: H
authors.lastname: Peerzada
authors.forename: Jay A
authors.initials: JA
authors.lastname: Gandhi
authors.forename: Allan J
authors.initials: AJ
authors.lastname: Guimaraes
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Nosanchuk
authors.forename: Luis R
authors.initials: LR
authors.lastname: Martinez
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D007109:Immunity / Q000187:drug effects*; D007249:Inflammation / Q000276:immunology; D007668:Kidney / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects*; D008099:Liver / Q000187:drug effects; D008694:Methamphetamine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine