title: Synthesis and antimicrobial activity of silver-doped hydroxyapatite nanoparticles.
abstract: The synthesis of nanosized particles of Ag-doped hydroxyapatite with antibacterial properties is of great interest for the development of new biomedical applications. The aim of this study was the evaluation of Ca(10-x)Ag(x)(PO4)6(OH)2 nanoparticles (Ag:HAp-NPs) for their antibacterial and antifungal activity. Resistance to antimicrobial agents by pathogenic bacteria has emerged in the recent years and became a major health problem. Here, we report a method for synthesizing Ag doped nanocrystalline hydroxyapatite. A silver-doped nanocrystalline hydroxyapatite was synthesized at 100°C in deionised water. Also, in this paper Ag:HAp-NPs are evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria and fungal strains. The specific antimicrobial activity revealed by the qualitative assay is demonstrating that our compounds are interacting differently with the microbial targets, probably due to the differences in the microbial wall structures.
authors.affiliation: Department of Multifunctional Materials and Structures Laboratory, National Institute of Materials Physics, 105 Bis Atomistilor, P.O. Box MG 07, 077125 Magurele, Romania.
authors.forename: Carmen Steluta
authors.initials: CS
authors.lastname: Ciobanu
authors.forename: Simona Liliana
authors.initials: SL
authors.lastname: Iconaru
authors.forename: Mariana Carmen
authors.initials: MC
authors.lastname: Chifiriuc
authors.forename: Adrian
authors.initials: A
authors.lastname: Costescu
authors.forename: Philippe
authors.initials: P
authors.lastname: Le Coustumer
authors.forename: Daniela
authors.initials: D
authors.lastname: Predoi
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D018441:Biofilms; D015195:Drug Design; D017886:Durapatite / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D012834:Silver; D017886:Durapatite