title: Size-tunable drug-delivery capsules composed of a magnetic nanoshell.
abstract: Nano-sized FePt capsules with two types of ultrathin shell were fabricated using a template method for use in a nano-scale drug delivery system. One capsule was composed of an inorganic-organic hybrid shell of a water-soluble polymer and FePt nanoparticles, and the other capsule was composed of a network of fused FePt nanoparticles. We demonstrated that FePt nanoparticles selectively accumulated on the polymer molecules adsorbed on the template silica particles, and investigated the morphologies of the particle accumulation by changing the concentration of the polymer solution with which the template particles were treated. Capsular size was reduced from 340 to less than 90 nm by changing the size of the silica template particles, and the shell thickness was controlled by changing the amount of FePt nanoparticles adsorbed on the template particles. The hybrid shell was maintained by the connection of FePt nanoparticles and polymer molecules, and the shell thickness was 10 nm at the maximum. The FePt network shell was fabricated by hydrothermal treatment of the FePt/polymer-modified silica composite particles. The FePt network shell was produced from only the FePt alloy, and the shell thickness was 3 nm. Water-soluble anti-cancer drugs could be loaded into the hollow space of FePt network capsules, and lipid-coated FePt network capsules loaded with anti-cancer drugs showed cellular toxicity. The nano-sized capsular structure and the ultrathin shell suggest applicability as a drug carrier in magnetically guided drug delivery systems.
authors.affiliation: Department of Innovative and Engineered Materials, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: Teruaki
authors.initials: T
authors.lastname: Fuchigami
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kitamoto
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Namiki
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D002214:Capsules / Q000737:chemistry; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D057145:Nanoshells / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D002214:Capsules; D004337:Drug Carriers; D008055:Lipids; D011108:Polymers; D012822:Silicon Dioxide
keywords: hydrothermal treatment; magnetic hollow sphere; magnetically guided drug delivery system; nano-scale drug delivery system; organic-inorganic magnetic material; porous capsule; size-controllable