title: Effects of CXCL13 inhibition on lymphoid follicles in models of autoimmune disease.
abstract: The chemokine CXCL13 has a key role in secondary lymphoid tissue orchestration and lymphoid neogenesis. Transgenic mice deficient in CXCL13 or its receptor CXCR5 have severely impaired lymph node development, lack peritoneal B-lymphocytes and are deficient in circulating antibodies to common bacterial antigens. However, total circulating numbers of B-lymphocytes are slightly elevated and humoral responses to T-dependent or blood-borne antigens are relatively normal. Lymphoid neogenesis is an aberrant process that occurs in chronically inflamed tissue and provides a microenvironment supportive of pathogenic B-cell survival and activation. Here, we describe the impact of therapeutic dosing of a CXCL13 antibody in a mouse model of arthritis, and detail the contribution CXCL13 makes to lymphoid follicle microenvironment, without affecting humoral immune responses.
authors.affiliation: MedImmune Ltd, Cambridge, UK. finchd@medimmune.com
authors.forename: Donna K
authors.initials: DK
authors.lastname: Finch
authors.forename: Rachel
authors.initials: R
authors.lastname: Ettinger
authors.forename: Jodi L
authors.initials: JL
authors.lastname: Karnell
authors.forename: Ronald
authors.initials: R
authors.lastname: Herbst
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Sleeman
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D054382:Chemokine CXCL13 / Q000037:antagonists & inhibitors* / Q000276:immunology; D004195:Disease Models, Animal; D008221:Lymphoid Tissue / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic; D054380:Receptors, CXCR5 / Q000276:immunology
chemical_list: D054382:Chemokine CXCL13; C486386:Cxcl13 protein, mouse; D054380:Receptors, CXCR5