title: The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate.
abstract: Bile acids have emerged as a new class of signaling molecules that play a role in metabolism. Studies in mice have shown that the bile acid receptor TGR5 mediates several of these effects but the metabolic function of TGR5 in humans is less well established. Here we show that human adipose tissue TGR5 expression is positively correlated to obesity and reduced during diet-induced weight loss. Adipose tissue TGR5 expression was also positively correlated to resting metabolic rate. Our study indicates that human adipose tissue contributes to the TGR5 mediated metabolic effects of bile acids and plays a role in energy expenditure.
authors.affiliation: Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. per-arne.svensson@medic.gu.se
authors.forename: Per-Arne
authors.initials: PA
authors.lastname: Svensson
authors.forename: Maja
authors.initials: M
authors.lastname: Olsson
authors.forename: Johanna C
authors.initials: JC
authors.lastname: Andersson-Assarsson
authors.forename: Magdalena
authors.initials: M
authors.lastname: Taube
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Pereira
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
authors.forename: Peter
authors.initials: P
authors.lastname: Jacobson
mesh_terms: D052437:Adipocytes, Brown / Q000378:metabolism / Q000473:pathology; D052438:Adipocytes, White / Q000378:metabolism / Q000473:pathology; D000328:Adult; D001481:Basal Metabolism; D001707:Biopsy, Needle; D015992:Body Mass Index; D031204:Caloric Restriction; D016022:Case-Control Studies; D004734:Energy Metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000378:metabolism; D009765:Obesity / Q000178:diet therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D050151:Subcutaneous Fat / Q000378:metabolism* / Q000473:pathology; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology; D000071256:Uncoupling Protein 1; D015431:Weight Loss
chemical_list: C473772:GPBAR1 protein, human; D007473:Ion Channels; D024101:Mitochondrial Proteins; D043562:Receptors, G-Protein-Coupled; D000071256:Uncoupling Protein 1