title: Salen promoted enantioselective Nazarov cyclizations of activated and unactivated dienones.
abstract: A novel class of chiral 5,5'-di(2,4,6-trialkyl)aryl salen-metal complexes have been developed and shown to catalyze highly enantioselective Nazarov cyclization reactions, giving rise to cyclopentenoids in 90:10-98:2 er. Significantly, the catalysts also promote, for the first time, highly enantioselective Nazarov reactions of "unactivated" dienones, producing hydrindenone products having in place three contiguous chiral centers.
authors.affiliation: Department of Chemistry, The University of Chicago , 5735 South Ellis Avenue, Chicago, Illinois 60637, United States.
authors.forename: Gerri E
authors.initials: GE
authors.lastname: Hutson
authors.forename: Yunus E
authors.initials: YE
authors.lastname: Türkmen
authors.forename: Viresh H
authors.initials: VH
authors.lastname: Rawal
mesh_terms: D002384:Catalysis; D002857:Chromium / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D003500:Cyclization; D005029:Ethylenediamines / Q000138:chemical synthesis / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D056831:Coordination Complexes; D005029:Ethylenediamines; D007659:Ketones; D002857:Chromium; C011452:disalicylaldehyde ethylenediamine