title: Biological activity of Pd(II) complexes with mono- and disubstituted pyridines--experimental and theoretical studies.
abstract: Due to the similarity between Pd and Pt, the complexes of palladium(II) can be considered as potential anticancer agents. Activity of six PdCl2(X2Py)2 complexes (Py=pyridine, and X=CH3 or Cl) was measured by MTT test using MCF7, CCRF-SB, PC3 and human B-lymphoblastoid cell lines. We found that the effect of PdCl2(XnPy)2 was cell-specific and time-dependent. Obtained results were discussed and compared with the activation parameters calculated for the hydrolysis of PdCl2(XnPy)2, indicating a correlation between viability of MCF7 and CCRF-SB cells and rates of hydrolysis of the Pd(II) complexes.
authors.affiliation: Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland. akrogul@chem.uw.edu.pl
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Krogul
authors.forename: Jakub
authors.initials: J
authors.lastname: Cedrowski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Wiktorska
authors.forename: Wojciech P
authors.initials: WP
authors.lastname: Oziminski
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Skupińska
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Litwinienko
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D061986:MCF-7 Cells; D008958:Models, Molecular; D008968:Molecular Conformation; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D011725:Pyridines; D010165:Palladium; C008756:palladium chloride; C023666:pyridine