title: Three times spontaneous remission of severe aplastic anemia following granulocyte transfusion from related donors: a case report and literature review.
abstract: Aplastic anemia (AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes, resulting in the apoptosis of hematopoietic cells and bone marrow failure. Currently, hematopoietic stem cell transplantation (HSCT), immunosuppressive - therapy (IST), and supportive care (e.g. transfusion adjuvant therapy, hematopoietic growth factors, and prevention of infection) are the main treatments of AA. Granulocyte transfusion has recently been accepted as an useful adjuvant therapy of HSCT and intensive IST. This article reported a severe AA patient who failed to respond to IST, but achieved spontaneous remission three times after granulocyte transfusions from related donors. Such cases have rarely been reported. Existence of human leukocyte antigen (HLA) cross between the patient and his relatives may influence the T cell-mediated immunity, which might explain this patient's recovery.
authors.affiliation: Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Bao-zhi
authors.initials: BZ
authors.lastname: Fang
authors.forename: Guang-sheng
authors.initials: GS
authors.lastname: He
authors.forename: Hai-xia
authors.initials: HX
authors.lastname: Zhou
authors.forename: Hui-rong
authors.initials: HR
authors.lastname: Chang
authors.forename: De-pei
authors.initials: DP
authors.lastname: Wu
authors.forename: Ai-ning
authors.initials: AN
authors.lastname: Sun
authors.forename: Su-ning
authors.initials: SN
authors.lastname: Chen
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy*; D006098:Granulocytes / Q000637:transplantation*; D006801:Humans; D017708:Leukocyte Transfusion; D008297:Male; D012075:Remission, Spontaneous