title: Multiple unrelated malignancies following renal transplantation: an evaluation of four cases.
abstract: The risk of de novo malignancy is significantly higher in patients who have undergone organ transplantation than in the general population. Long-term immunosuppressive treatment, in addition to age, genetic predisposition and infectious agents, plays a major role in the development of malignancy. Although skin and hemopoietic system cancers are common, atypical presentations of malignancies may occasionally be seen during long-term follow-up in patients with functioning allografts. In this report, four cases, each with more than one different primary malignancy (one patient with three malignancies and three patients with two malignancies), are presented.
authors.affiliation: Division of Nephrology, Ege University School of Medicine, Turkey. etatar@hotmail.com
authors.forename: Erhan
authors.initials: E
authors.lastname: Tatar
authors.forename: Banu
authors.initials: B
authors.lastname: Sarsik
authors.forename: Ozkan
authors.initials: O
authors.lastname: Gungor
authors.forename: Banu
authors.initials: B
authors.lastname: Yaman
authors.forename: Nazan
authors.initials: N
authors.lastname: Ozsan
authors.forename: Seckin
authors.initials: S
authors.lastname: Cagirgan
authors.forename: Meltem
authors.initials: M
authors.lastname: Sezis Demirci
authors.forename: Taylan
authors.initials: T
authors.lastname: Ozgur Sezer
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Hoscoskun
authors.forename: Huseyin
authors.initials: H
authors.lastname: Toz
mesh_terms: D000328:Adult; D018265:Carcinoma, Papillary, Follicular / Q000209:etiology; D002292:Carcinoma, Renal Cell / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000209:etiology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000209:etiology; D016030:Kidney Transplantation; D054066:Leukemia, Large Granular Lymphocytic / Q000209:etiology; D008175:Lung Neoplasms / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000209:etiology; D016609:Neoplasms, Second Primary / Q000209:etiology*; D010157:Palatal Neoplasms / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology*; D012514:Sarcoma, Kaposi / Q000209:etiology; D012878:Skin Neoplasms / Q000209:etiology; D013274:Stomach Neoplasms / Q000209:etiology; D013964:Thyroid Neoplasms / Q000209:etiology; D013997:Time Factors; D014134:Tracheal Neoplasms / Q000209:etiology
chemical_list: D007166:Immunosuppressive Agents