title: Isomerization of terminal epoxides by a [Pd-H] catalyst: a combined experimental and theoretical mechanistic study.
abstract: An unusual palladium hydride complex has been shown to be a competent catalyst in the isomerization of a variety of terminal and internal epoxides. The reaction displayed broad scope and synthetic utility. Experimental and theoretical evidence are provided for an unprecedented hydride mechanism characterized by two distinct enantio-determining steps. These results hold promise for the development of an enantioselective variant of the reaction.
authors.affiliation: Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.
authors.forename: Devendra J
authors.initials: DJ
authors.lastname: Vyas
authors.forename: Evgeny
authors.initials: E
authors.lastname: Larionov
authors.forename: Céline
authors.initials: C
authors.lastname: Besnard
authors.forename: Laure
authors.initials: L
authors.lastname: Guénée
authors.forename: Clément
authors.initials: C
authors.lastname: Mazet