title: Intravenous paracetamol and dipyrone for postoperative analgesia after day-case tonsillectomy in children: a prospective, randomized, double blind, placebo controlled study.
abstract: Tonsillectomy is associated with severe postoperative pain for which, several drugs are employed for management.
  
  
  OBJECTIVE
  In this double-blind, placebo-controlled study we aimed to evaluate the efficacy of intravenous paracetamol and dipyrone when used for post-tonsillectomy analgesia in children.
  
  
  METHODS
  120 children aged 3-6 yr, undergoing tonsillectomy with or without adenoidectomy and/or ventilation tube insertion were randomized to receive intraoperative infusions of paracetamol (15 mg/kg), dipyrone (15 mg/kg) or placebo (0.9% NaCl). Evaluation was carried out at 0.25, 0.50, 1, 2, 4, 6h postoperatively. Pethidine 0.25 mg/kg was utilized as rescue analgesic. Cumulative pethidine requirement was the primary outcome. Pain intensity measurement, pain relief, sedation level, nausea and vomiting, postoperative bleeding and any other adverse effects were noted.
  
  
  RESULTS
  No significant difference was found in pethidine requirement between paracetamol and dipyrone groups. Cumulative pethidine requirement was significantly less in paracetamol and dipyrone groups vs. placebo. No significant difference was observed between groups in postoperative pain intensity scores throughout the study.
  
  
  CONCLUSIONS
  Intravenous paracetamol is found to have a similar analgesic efficacy as intravenous dipyrone and they both help to reduce the opioid requirement for postoperative analgesia in pediatric day-case tonsillectomy.
authors.affiliation: Departamento de Anestesiologia e Reanimação, Universidade Baskent, Turkey.
authors.forename: Aysu Inan
authors.initials: AI
authors.lastname: Kocum
authors.forename: Mesut
authors.initials: M
authors.lastname: Sener
authors.forename: Esra
authors.initials: E
authors.lastname: Caliskan
authors.forename: Nesrin
authors.initials: N
authors.lastname: Bozdogan
authors.forename: Deniz
authors.initials: D
authors.lastname: Micozkadioglu
authors.forename: Ismail
authors.initials: I
authors.lastname: Yilmaz
authors.forename: Anis
authors.initials: A
authors.lastname: Aribogan
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004177:Dipyrone / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008614:Meperidine / Q000008:administration & dosage; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D014068:Tonsillectomy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D004177:Dipyrone; D008614:Meperidine