title: Analysis of impurities in vertilmicin sulfate by liquid chromatography ion-trap mass spectrometry.
abstract: The characterization of impurities present in vertilmicin by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed phase (RP)-LC method using a C18 column resistant to basic pH with an alkaline (pH 11) aqueous mobile phase was developed and coupled to MS with an electrospray ionization (ESI) source in the positive ion mode which provides MS(n) capability. In total, 18 impurities were detected in a commercial sample. Eleven impurities described in this work were newly identified.
authors.affiliation: JiangSu Provincial Institute for Food and Drug Control, Nanjing 210008, China. yuanyaozuo@hotmail.com
authors.forename: Yao-zuo
authors.initials: YZ
authors.lastname: Yuan
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Xia-Lei
authors.initials: XL
authors.lastname: Fan
authors.forename: Chang-qin
authors.initials: CQ
authors.lastname: Hu
authors.forename: Shao-hong
authors.initials: SH
authors.lastname: Jin
authors.forename: Ann
authors.initials: A
authors.lastname: Van Schepdael
authors.forename: Jos
authors.initials: J
authors.lastname: Hoogmartens
authors.forename: Erwin
authors.initials: E
authors.lastname: Adams
mesh_terms: D000617:Aminoglycosides / Q000032:analysis* / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry; D002853:Chromatography, Liquid / Q000379:methods*; D004340:Drug Contamination; D006863:Hydrogen-Ion Concentration; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C487733:vertilmicin