title: Synthesis and characterization of a new class of anti-angiogenic agents based on ruthenium clusters.
abstract: New triruthenium-carbonyl clusters derivatized with glucose-modified bicyclophosphite ligands have been synthesized. These compounds were found to have cytostatic and cytotoxic activity and depending on the number of bicyclophosphite ligands, and could be tuned for either anti-cancer or specific anti-angiogenic activity. While some compounds had a broad cellular toxicity profile in several cell types others showed endothelial cell specific dose-dependent anti-proliferative and anti-migratory efficacy. A profound inhibition of angiogenesis was also observed in the in vivo chicken chorioallantoic membrane (CAM) model, and consequently, these new compounds have considerable potential in drug design, e.g. for the treatment of cancer.
authors.affiliation: 1] Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland [2] Department of Chemistry, Moscow State University, Leninskie Gory, 119991, Moscow, Russia.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Nazarov
authors.forename: Mathurin
authors.initials: M
authors.lastname: Baquié
authors.forename: Patrycja
authors.initials: P
authors.lastname: Nowak-Sliwinska
authors.forename: Olivier
authors.initials: O
authors.lastname: Zava
authors.forename: Judy R
authors.initials: JR
authors.lastname: van Beijnum
authors.forename: Michael
authors.initials: M
authors.lastname: Groessl
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Chisholm
authors.forename: Zohrab
authors.initials: Z
authors.lastname: Ahmadi
authors.forename: J Scott
authors.initials: JS
authors.lastname: McIndoe
authors.forename: Arjan W
authors.initials: AW
authors.lastname: Griffioen
authors.forename: Hubert
authors.initials: H
authors.lastname: van den Bergh
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dyson
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002642:Chick Embryo; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D018919:Neovascularization, Physiologic / Q000187:drug effects; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D020533:Angiogenesis Inhibitors; D012428:Ruthenium