title: A structure-activity relationship study on multi-heterocyclic molecules: two linked thiazoles are required for cytotoxic activity.
abstract: We report the synthesis, cytotoxicity, and phenotypic analysis of oxazole and thiazole containing fragments. Evaluating the optimal size and heterocycle for growth inhibition and apoptosis showed that activity required at least two thiazoles sequentially connected. This is the first detailed comparison of biological activity between multi-heterocyclic containing fragments.
authors.affiliation: School of Chemistry, 219 Dalton, Gate 2 High Street, University of New South Wales, Sydney, NSW, 2052, Australia. Tel: +61-4-1672-8896.
authors.forename: Seong Jong
authors.initials: SJ
authors.lastname: Kim
authors.forename: Chun Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Chung-Mao
authors.initials: CM
authors.lastname: Pan
authors.forename: Dimple P
authors.initials: DP
authors.lastname: Rananaware
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Ramsey
authors.forename: Shelli R
authors.initials: SR
authors.lastname: McAlpine