title: Association between obesity-related gene FTO and ADHD.
abstract: OBJECTIVE
  Attention-deficit/hyperactivity disorder (ADHD) is an etiologically complex heterogeneous behavioral disorder. Several studies have reported that ADHD subjects are more likely to be overweight/obese and that this comorbidity may be due to shared genetic factors. The objective of this study is to explore the association between ADHD and FTO, a gene strongly associated with obesity in genome-wide studies.
  
  
  METHODS
  One tag SNP (single-nucleotide polymorphism, rs8050136, risk allele A) in the FTO gene was selected and its association with ADHD was tested. Family-based association tests (FBATs) were conducted with the categorical diagnosis of ADHD as well as behavioral and cognitive phenotypes related to ADHD. Furthermore, stratified FBAT analyses based on maternal smoking during pregnancy (MSDP) status were conducted.
  
  
  RESULTS
  Statistically significant associations were observed between rs8050136 and several of the traits tested in the total sample. These associations were stronger when the analysis was restricted to children who were not exposed to MSDP.
  
  
  CONCLUSIONS
  These exploratory results suggest the involvement of the FTO SNP rs8050136 in modulating the risk for ADHD, particularly in those children who were not exposed to MSDP. If confirmed, they may explain, at least in part, the complex links between obesity and ADHD.
authors.affiliation: Clinical Research Division, Douglas Mental Health University Institute, McGill University, Quebec, Canada; Department of Human Genetics, McGill University, Quebec, Canada.
authors.forename: Zia
authors.initials: Z
authors.lastname: Choudhry
authors.forename: Sarojini M
authors.initials: SM
authors.lastname: Sengupta
authors.forename: Natalie
authors.initials: N
authors.lastname: Grizenko
authors.forename: Geeta A
authors.initials: GA
authors.lastname: Thakur
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Fortier
authors.forename: Norbert
authors.initials: N
authors.lastname: Schmitz
authors.forename: Ridha
authors.initials: R
authors.lastname: Joober
mesh_terms: D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology* / Q000235:genetics*; D002648:Child; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology* / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human