title: Contribution of bone marrow derived cells to the pancreatic tumor microenvironment.
abstract: Pancreatic cancer is a complex, aggressive, and heterogeneous malignancy driven by the multifaceted interactions within the tumor microenvironment. While it is known that the tumor microenvironment accommodates many cell types, each playing a key role in tumorigenesis, the major source of these stromal cells is not well-understood. This review examines the contribution of bone marrow-derived cells (BMDC) to pancreatic carcinogenesis, with respect to their role in constituting the tumor microenvironment. In particular, their role in supporting fibrosis, immunosuppression, and neovascularization will be discussed.
authors.affiliation: Food Bioactives and Pancreatic Cancer Biology Group, School of Environmental and Life Sciences, University of Newcastle Ourimbah, NSW, Australia ; Cancer Research Program, Garvan Institute of Medical Research Darlinghurst, Sydney, NSW, Australia.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Scarlett
keywords: bone marrow derived stem cells; fibrosis; immunosuppression; neovascularization; pancreatic cancer; pancreatic stellate cells; stroma