title: Evaluation of adhesion properties and antibacterial activities of the infant gut commensal Bifidobacterium bifidum PRL2010.
abstract: Bifidobacteria are extensively exploited by the food industry as health-promoting microorganisms. However, very little is known about the molecular mechanisms responsible for these beneficial activities, or the molecular players that sustain their ability to colonize and persist within the human gut. Here, we have investigated the enteric adaptation features of the gut commensal Bifidobacterium bifidum PRL2010, originally isolated from infant feces. This strain was able to survive under gastrointestinal challenges, while it was shown to adhere to human epithelial intestinal cell monolayers (Caco 2 and HT-29), thereby inhibiting adhesion of pathogenic bacteria such as Escherichia coli and Cronobacter sakazakii.
authors.affiliation: Department of Genetics, Biology of Microorganisms, Anthropology and Evolution, University of Parma, Parma, Italy.
authors.forename: Fausta
authors.initials: F
authors.lastname: Serafini
authors.forename: Francesco
authors.initials: F
authors.lastname: Strati
authors.forename: Patricia
authors.initials: P
authors.lastname: Ruas-Madiedo
authors.forename: Francesca
authors.initials: F
authors.lastname: Turroni
authors.forename: Elena
authors.initials: E
authors.lastname: Foroni
authors.forename: Sabrina
authors.initials: S
authors.lastname: Duranti
authors.forename: Francesco
authors.initials: F
authors.lastname: Milano
authors.forename: Alessio
authors.initials: A
authors.lastname: Perotti
authors.forename: Alice
authors.initials: A
authors.lastname: Viappiani
authors.forename: Simone
authors.initials: S
authors.lastname: Guglielmetti
authors.forename: Annamaria
authors.initials: A
authors.lastname: Buschini
authors.forename: Abelardo
authors.initials: A
authors.lastname: Margolles
authors.forename: Douwe
authors.initials: D
authors.lastname: van Sinderen
authors.forename: Marco
authors.initials: M
authors.lastname: Ventura
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000898:Antibiosis; D001422:Bacterial Adhesion; D001644:Bifidobacterium / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification / Q000502:physiology*; D001647:Bile Acids and Salts / Q000494:pharmacology; D018938:Caco-2 Cells; D044083:Cronobacter sakazakii / Q000502:physiology; D004847:Epithelial Cells / Q000382:microbiology; D004926:Escherichia coli / Q000502:physiology; D005243:Feces / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000382:microbiology*; D019073:HT29 Cells; D054884:Host-Pathogen Interactions; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007422:Intestines / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D019936:Probiotics; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001647:Bile Acids and Salts; D012965:Sodium Chloride