title: Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity.
abstract: It is the first report of 1,3,4,5-tetrasubstituted 1,2,3,6-tetrahydropyrimidines derivatives, catalyzed by ZrOCl2. The mild reaction conditions, excellent yields in shorter reaction time and evasion of cumbersome workup procedures make this process economically lucrative for industrial application. The novelty and highlight of the present method is the promising antibacterial and antifungal activity shown by compounds (4a, 4b, 4e, 4f, 4h and 4l) compared to standard.
authors.affiliation: Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, MS, India.
authors.forename: Sunil N
authors.initials: SN
authors.lastname: Darandale
authors.forename: Dattatraya N
authors.initials: DN
authors.lastname: Pansare
authors.forename: Nayeem A
authors.initials: NA
authors.lastname: Mulla
authors.forename: Devanand B
authors.initials: DB
authors.lastname: Shinde
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002384:Catalysis; D004926:Escherichia coli / Q000187:drug effects; D055772:Green Chemistry Technology; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D015040:Zirconium / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D011743:Pyrimidines; D015040:Zirconium; C030986:pyrimidine; C026090:zirconium oxychloride