title: A retrospective longitudinal cohort study of antihypertensive drug use and new-onset diabetes in Taiwanese patients.
abstract: Antihypertensive drugs have been linked to new-onset diabetes (NOD); however, data on the effect of these drugs on the development of NOD in hypertensive patients has not been well determined in a clinical setting. The aim was to investigate the association between antihypertensive drugs and NOD in Taiwan. We conducted a retrospective study of hypertensive Taiwanese patients receiving antihypertensive drugs treatment between January 2006 and December 2011. Clinical information and laboratory parameters were collected by reviewing the medical records. We estimated the odds ratios (ORs) of NOD associated with antihypertensive drug use; nondiabetic subjects served as the reference group. A total of 120 NOD cases were identified in 1001 hypertensive patients during the study period. The risk of NOD after adjusting sex, age, baseline characteristics, and lipid profiles was higher among users of thiazide diuretics (OR, 1.65; 95% confidence interval (CI), 1.12-2.45) and nondihydropyridine (non-DHP) calcium channel blockers (CCBs) (OR, 1.96; 95% CI, 1.01-3.75) than among nonusers. Other antihypertensive drug classes were not associated with risk of NOD. Our results show that patients with hypertension who take thiazide diuretics and non-DHP CCBs are at higher risk of developing NOD than those who take other classes of antihypertensive drugs in Taiwan.
authors.affiliation: Department of Pharmacy, China Medical University Hospital, Beikang Campus, Taichung 40402, Taiwan.
authors.forename: Ching-Ya
authors.initials: CY
authors.lastname: Huang
authors.forename: Tsochiang
authors.initials: T
authors.lastname: Ma
authors.forename: Liyun
authors.initials: L
authors.lastname: Tien
authors.forename: Yow-Wen
authors.initials: YW
authors.lastname: Hsieh
authors.forename: Shwu-Yi
authors.initials: SY
authors.lastname: Lee
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Chen
authors.forename: Gwo-Ping
authors.initials: GP
authors.lastname: Jong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan; D049971:Thiazides / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D049971:Thiazides