title: Frequency of impaired glucose tolerance and diabetes mellitus in subjects with fasting blood glucose below 6.1 mmol/L (110 mg/dL).
abstract: The diagnosis of diabetes mellitus by the available criteria is controversial and relies heavily on fasting glucose results. This cross-sectional study in 2010-2011 aimed to measure the frequency of impaired glucose tolerance and diabetes mellitus in 127 subjects having fasting blood glucose < 7.0 mmol/L and to measure the agreement between different standard diagnostic criteria. Subjects presenting to a laboratory for analysis of fasting blood glucose for excluding diabetes mellitus underwent a 2-hour 75 g oral glucose challenge. A total of 40.6% of subjects with fasting blood glucose from 5.6-6.0 mmol/L had abnormal glucose regulation on the basis ofthe gold standard glucose challenge. Agreement between American Diabetes Association and World Health Organization diagnostic criteria was only fair (kappa = 0.32). Abnormalities of glucose metabolism including impaired glucose tolerance and diabetes mellitus can exist at fasting blood glucose results < 6.1 mmol/L (110 mg/dL).
authors.affiliation: Department of Pathology, PNS Rahat Hospital, Karachi, Pakistan. sik_cpsp@yahoo.com
authors.forename: S H
authors.initials: SH
authors.lastname: Khan
authors.forename: A
authors.initials: A
authors.lastname: Ijaz
authors.forename: S A Raza
authors.initials: SA
authors.lastname: Bokhari
authors.forename: M S
authors.initials: MS
authors.lastname: Hanif
authors.forename: N
authors.initials: N
authors.lastname: Azam
mesh_terms: D000328:Adult; D001786:Blood Glucose; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D005951:Glucose Tolerance Test / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D012307:Risk Factors; D014944:World Health Organization
chemical_list: D001786:Blood Glucose