title: Luminescent organoplatinum(II) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity.
abstract: A panel of luminescent platinum(II) complexes containing bidentate N-heterocyclic carbene ligands selectively localize to the endoplasmic reticulum (ER) domain, induce ER stress and cell apoptosis. Some of them show potent photo-toxicity to cancer cells.
authors.affiliation: State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong.
authors.forename: Taotao
authors.initials: T
authors.lastname: Zou
authors.forename: Chun-Nam
authors.initials: CN
authors.lastname: Lok
authors.forename: Yi Man Eva
authors.initials: YM
authors.lastname: Fung
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects; D006801:Humans; D008024:Ligands; D008027:Light; D049449:Luminescence; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D056831:Coordination Complexes; D003603:Cytotoxins; D008024:Ligands; D009944:Organoplatinum Compounds; C030011:carbene; D008697:Methane