title: A bi-faceted role of estrogen receptor β in breast cancer.
abstract: Despite over 15 years of research, the exact role, if any, played by estrogen receptor β (ERβ) in human breast cancer remains elusive. A large body of data both in vitro and in vivo supports its role as an antiproliferative, pro-apoptotic factor especially when co-expressed with ERα. However, there is a smaller body of data associating ERβ with growth and survival in breast cancer. In clinical studies and most often in cell culture studies, the pro-growth and pro-survival activity of ERβ occurs in ERα-negative breast cancer tissue and cells. This bi-faceted role of ERβ is discussed in this review.
authors.affiliation: Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9. eleygue@cc.umanitoba.ca
authors.forename: Etienne
authors.initials: E
authors.lastname: Leygue
authors.forename: Leigh C
authors.initials: LC
authors.lastname: Murphy
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism*; D005260:Female; D006801:Humans
chemical_list: D047629:Estrogen Receptor beta
keywords: breast; endocrine therapy resistance; estrogen receptor; estrogen therapy