title: [Vismodegib in metastasized basal cell carcinoma].
abstract: BACKGROUND
  Generally basal cell carcinoma can be simply and curatively treated. However, large and long-standing tumours can be locally very destructive and in rare cases even metastasize. Hedgehog pathway inhibitors such as vismodegib constitute a new and promising therapy for metastatic or locally advanced basal cell carcinoma.
  
  
  METHODS
  We describe a patient with metastasized basal cell carcinoma and basal cell nevus syndrome who, in the context of a study, was successfully treated with vismodegib. The main undesirable effects in our patient were muscle cramps, loss of taste, nausea and hair loss.
  
  
  CONCLUSIONS
  Basal cell carcinoma is potentially a locally destructive skin tumour that only very rarely metastasizes. Hedgehog pathway inhibitors such as vismodegib can be administered in a selected group of patients with basal cell carcinoma.
authors.affiliation: MUMC, afd. Dermatologie, Maastricht, the Netherlands. marieke.reinders@mumc.nl
authors.forename: M G H C Marieke
authors.initials: MG
authors.lastname: Reinders
authors.forename: Luc
authors.initials: L
authors.lastname: Dirix
authors.forename: Klara
authors.initials: K
authors.lastname: Mosterd
authors.forename: Remco
authors.initials: R
authors.lastname: van Doorn
mesh_terms: D000813:Anilides / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D005260:Female; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D008875:Middle Aged; D011725:Pyridines / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000813:Anilides; D000970:Antineoplastic Agents; D053823:Hedgehog Proteins; C538724:HhAntag691; D011725:Pyridines