title: Rapid EEG activity during sleep dominates in mild traumatic brain injury patients with acute pain.
abstract: Chronic pain is a highly prevalent post-concussion symptom occurring in a majority of patients with mild traumatic brain injury (mTBI). About half of patients with mTBI report sleep-wake disturbances. It is known that pain can alter sleep quality in this population, but the interaction between pain and sleep is not fully understood. This study aimed to identify how pain affects subjective sleep (Pittsburgh Sleep Quality Index [PSQI]), sleep architecture, and quantitative electroencephalographic (qEEG) brain activity after mTBI. Twenty-four mTBI patients complaining of sleep-wake disturbances, with and without pain (8 and 16, respectively), were recruited 45 (±22.7) days post-trauma on average. Data were compared with those of 18 healthy controls (no sleep or pain complaints). The PSQI, sleep architecture, and qEEG activity were analyzed. Pain was assessed using questionnaires and a 100-mm visual analogue scale. Patients with mTBI reported three times poorer sleep quality than controls on the PSQI. Sleep architecture significantly differed between patients with mTBI and controls but was within normal range. Global qEEG showed lower delta (deep sleep) and higher beta and gamma power (arousal) at certain EEG derivations in patients with mTBI compared with controls (p<0.04). Patients with mTBI with pain, however, showed greater increase in rapid EEG frequency bands, mostly during REM sleep, and beta bands in non-REM sleep compared with patients with mTBI without pain and controls (p<0.001). Pain in patients with mTBI was associated with more rapid qEEG activity, mostly during REM sleep, suggesting that pain is associated with poor sleep and is a critical factor in managing post-concussion symptoms.
authors.affiliation: Centre for Advanced Research in Sleep Medicine, Sacré-Cœur Hôspital, Montreal, Québec H4J 1C5, Canada.
authors.forename: Samar
authors.initials: S
authors.lastname: Khoury
authors.forename: Florian
authors.initials: F
authors.lastname: Chouchou
authors.forename: Florin
authors.initials: F
authors.lastname: Amzica
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Giguère
authors.forename: Ronald
authors.initials: R
authors.lastname: Denis
authors.forename: Guy A
authors.initials: GA
authors.lastname: Rouleau
authors.forename: Gilles J
authors.initials: GJ
authors.lastname: Lavigne
mesh_terms: D059787:Acute Pain / Q000209:etiology* / Q000503:physiopathology; D000293:Adolescent; D001930:Brain Injuries / Q000150:complications; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography; D038223:Post-Concussion Syndrome / Q000150:complications*; D012890:Sleep / Q000502:physiology; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000503:physiopathology; D055815:Young Adult