title: Cell mechanosensitivity: mechanical properties and interaction with gravitational field.
abstract: This paper addressed the possible mechanisms of primary reception of a mechanical stimulus by different cells. Data concerning the stiffness of muscle and nonmuscle cells as measured by atomic force microscopy are provided. The changes in the mechanical properties of cells that occur under changed external mechanical tension are presented, and the initial stages of mechanical signal transduction are considered. The possible mechanism of perception of different external mechanical signals by cells is suggested.
authors.affiliation: State Research Center of Russian Federation Institute of Biomedical Problems, Russian Academy of Sciences, 76-a, Khoroshevskoyoe shosse, Moscow 123007, Russia. iogneva@yandex.ru
authors.forename: I V
authors.initials: IV
authors.lastname: Ogneva
mesh_terms: D000818:Animals; D002460:Cell Line; D003599:Cytoskeleton / Q000378:metabolism; D004574:Electromagnetic Fields; D006112:Gravitation; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D040542:Mechanotransduction, Cellular; D051379:Mice; D008809:Mice, Inbred C3H; D018625:Microscopy, Atomic Force; D018482:Muscle, Skeletal / Q000473:pathology; D009206:Myocardium / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000166:cytology; D011817:Rabbits; D013314:Stress, Mechanical
chemical_list: D007473:Ion Channels