title: Mathematics of small stochastic reaction networks: a boundary layer theory for eigenstate analysis.
abstract: We study and analyze the stochastic dynamics of a reversible bimolecular reaction A + B ↔ C called the "trivalent reaction." This reaction is of a fundamental nature and is part of many biochemical reaction networks. The stochastic dynamics is given by the stochastic master equation, which is difficult to solve except when the equilibrium state solution is desired. We present a novel way of finding the eigenstates of this system of difference-differential equations, using perturbation analysis of ordinary differential equations arising from approximation of the difference equations. The time evolution of the state probabilities can then be expressed in terms of the eigenvalues and the eigenvectors.
authors.affiliation: Department of Computer Science, and Institute for Genomics and Bioinformatics, University of California, Irvine, California 92617, USA. emj@uci.edu
authors.forename: Eric
authors.initials: E
authors.lastname: Mjolsness
authors.forename: Upendra
authors.initials: U
authors.lastname: Prasad
mesh_terms: D001669:Biochemical Phenomena; D003198:Computer Simulation; D007700:Kinetics; D008954:Models, Biological; D015233:Models, Statistical; D013269:Stochastic Processes