title: [D allele of the angiotensin converting enzyme gene is a putative risk factor of restenosis after coronary stenting in patients with coronary heart disease].
abstract: We undertook a comparative analysis of allele frequency distribution and I/D polymorphism of the angiotensin converting enzyme (ACE) gene in patients with coronary heart disease (CHD) undergoing coronary stenting with and without signs of restenosis. There were no significant difference between the groups in the genotype frequency distribution of I/D polymorphism of the CAE gene (p = 0.061). The occurrence of D allele in the patients with restenosis was higher than that of I allele (chi-square test 4.117, p = 0.042). Relative risk for the carriers of D and I alleles was 0.35 and 2.83 respectively. It is concluded that the presence of D allele of I/D polymorphism of the CAE gene in patients with chronic CHD may be a risk factor of restenosis of stented coronary arteries.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Rebrova
authors.forename: E F
authors.initials: EF
authors.lastname: Muslimova
authors.forename: S A
authors.initials: SA
authors.lastname: Afanas'ev
authors.forename: T N
authors.initials: TN
authors.lastname: Sergienko
authors.forename: A N
authors.initials: AN
authors.lastname: Repin
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000201:enzymology / Q000235:genetics* / Q000601:surgery; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000235:genetics / Q000517:prevention & control; D004247:DNA / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D015607:Stents; D014057:Tomography, X-Ray Computed
chemical_list: D004247:DNA; D007703:Peptidyl-Dipeptidase A