title: Targeting SIRPα in cancer.
abstract: Strategies to harness the patient's immune system to fight cancer have mainly involved adoptive T-cell transfer. We and others have recently highlighted an alternative immunotherapeutic approach to cancer that consists of enhancing the macrophage-mediated clearance of leukemia cells through the blockade of inhibitory signals transmitted by signal regulatory protein α (SIRPα).
authors.affiliation: The Campbell Family Cancer Research Institute; Ontario Cancer Institute; Princess Margaret Hospital; Toronto, ON Canada.
authors.forename: Jenny M
authors.initials: JM
authors.lastname: Ho
authors.forename: Jayne S
authors.initials: JS
authors.lastname: Danska
authors.forename: Jean C Y
authors.initials: JC
authors.lastname: Wang
keywords: AML; SIRPα; leukemia; leukemia stem cells; macrophages