title: Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention.
abstract: Association of obesity risk alleles of single nucleotide polymorphisms (SNPs) near or in the SH2B adaptor protein 1 gene (SH2B1) and increased body mass index (BMI) has been often described. A gene in close proximity, apolipoprotein B48 receptor gene (APOB48R), is tagged by the same SNP(s).We analyzed 454 overweight and obese children and adolescents (10.8±2.6 years, BMI-SDS 2.4±0.5; 55% girls) who completed a 1-year lifestyle intervention ('Obeldicks' program). Carriers of obesity risk alleles of non-synonymous SNPs in SH2B1 (rs7498665, Thr484Ala) or APOB48R (rs180743, Pro419Ala), as genotyped by TaqMan, were analysed for changes in anthropometrics (body-mass index (BMI), and standardized BMI (BMI-SDS)), blood pressure (systolic and diastolic) and plasma parameters (total cholesterol, LDL-cholesterol, HDL-cholesterol, triacylglycerides, glucose, insulin, and HOMA).We observed no evidence for an association of the obesity risk alleles to alterations in any of the analyzed phenotypes. Both mean BMI and BMI-SDS improved during the intervention independent of genotype. The mean systolic blood pressure was lowered and concentrations of HDL-cholesterol increased significantly.The obesity risk alleles of non-synonymous SNPs at SH2B1 and APOB48R have no strong effect on weight loss-related phenotypes in overweight children after a 1-year lifestyle intervention.
authors.affiliation: Department of Child and Adolescent Psychiatry, University of -Duisburg-Essen, Germany.
authors.forename: A-L
authors.initials: AL
authors.lastname: Volckmar
authors.forename: C
authors.initials: C
authors.lastname: Pütter
authors.forename: J-Y
authors.initials: JY
authors.lastname: Song
authors.forename: J
authors.initials: J
authors.lastname: Graniger
authors.forename: N
authors.initials: N
authors.lastname: Knoll
authors.forename: B
authors.initials: B
authors.lastname: Wolters
authors.forename: J
authors.initials: J
authors.lastname: Hebebrand
authors.forename: A
authors.initials: A
authors.lastname: Scherag
authors.forename: T
authors.initials: T
authors.lastname: Reinehr
authors.forename: A
authors.initials: A
authors.lastname: Hinney
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000097:blood / Q000235:genetics*; D000293:Adolescent; D000483:Alleles; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D018110:Receptors, Lipoprotein / Q000097:blood / Q000235:genetics*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D001786:Blood Glucose; D008078:Cholesterol, LDL; D007328:Insulin; D018110:Receptors, Lipoprotein; C518910:SH2B1 protein, human; D014280:Triglycerides