title: Associations of SAA1 gene polymorphism with lipid lelvels and osteoporosis in Chinese women.
abstract: BACKGROUND
  The development of osteoporosis is associated with several risk factors, such as genetic polymorphisms and enviromental factors. This study assessed the correlation between SAA1 gene rs12218 polymorphism and HDL-C lelvels and osteoporosis in a population of Chinese women.
  
  
  METHODS
  A total of 387 postmenopausal female patients who were diagnosed with osteoporosis (case group) based on bone mineral density measurements via dual-energy x-ray absorptiometry and 307 females with no osteoporosis (control group) were included in this study. Correlations between SAA1 gene rs12218 polymorphism and osteoporosis and HDL-C level were investigated through the identification of SAA1 gene rs12218 polymorphism genotypes using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  The TT genotype of rs12218 was more frequently in osteoporosis patients than in control subjects (P <0.001). And the rs12218 was found to be associated with plasma TG, HDL-C, LDL-C, and BMD levels in osteoporosis patients (P<0.05).
  
  
  CONCLUSIONS
  The present results indicate that both osteoporosis and lipids levels are associated with the TT genotype of rs12218 in the human SAA1 gene.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. fengzhengping_f@yeah.net
authors.forename: Zheng-Ping
authors.initials: ZP
authors.lastname: Feng
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Jiang
authors.forename: Hua-Cong
authors.initials: HC
authors.lastname: Deng
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhou
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Que
authors.forename: Jia
authors.initials: J
authors.lastname: Du
mesh_terms: D015519:Bone Density / Q000235:genetics; D002681:China; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008055:Lipids / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000685:Serum Amyloid A Protein / Q000235:genetics*
chemical_list: D008076:Cholesterol, HDL; D008055:Lipids; C521404:SAA1 protein, human; D000685:Serum Amyloid A Protein