title: Immunology of aging and cancer development.
abstract: The incidence and prevalence of most cancers increase with age. The immune system is a unique mechanism of defense against pathogens and possibly cancers, however there is a body of evidence that the immune system of the aged is eroded, a phenomenon termed immunosenescence. Each arm of the immune system, innate and adaptive, is altered with aging, contributing to increased tumorigenesis. Related to immunosenescence, a low-grade inflammation also develops with aging contributing also to increase carcinogenesis. Understanding the contribution of immunosenescence to cancer development and progression may lead to better interventions in the elderly.
authors.affiliation: Research Center on Aging, Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada. tamas.fulop@usherbrooke.ca
authors.forename: Tamas
authors.initials: T
authors.lastname: Fulop
authors.forename: Anis
authors.initials: A
authors.lastname: Larbi
authors.forename: Rami
authors.initials: R
authors.lastname: Kotb
authors.forename: Graham
authors.initials: G
authors.lastname: Pawelec
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology; D000368:Aged; D000375:Aging / Q000276:immunology*; D000954:Antigens, Surface / Q000378:metabolism; D063646:Carcinogenesis / Q000187:drug effects / Q000276:immunology; D016021:Epidemiologic Studies; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate / Q000502:physiology; D007249:Inflammation / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D059016:Tumor Microenvironment / Q000276:immunology
chemical_list: D000954:Antigens, Surface; D051192:Receptors, Pattern Recognition