title: The association between the poly(A) polymorphism in the VDR gene and cancer risk: a meta-analysis.
abstract: The poly(A) polymorphism (L/S) in the VDR gene has been implicated in susceptibility of cancer, but a number of studies have reported inconclusive results. The aim of this study is to investigate the relationship between the poly(A) polymorphism in the VDR gene and cancer risk by meta-analysis. We searched PubMed database, EMBASE database, CNKI database, and Wanfang database, covering all studies until January 22, 2013. Statistical analysis was performed by using the software Revman4.2 and STATA 10.0. A total 8,186 cancer cases and 8,685 controls in 19 case-control studies from 15 studies were identified for data analysis. The results suggested that the S allele carriers (SS+SL) did not have an increased or decreased risk of cancer when compared with the homozygote LL carriers (odds ratio (OR) =0.96, 95 % CI=0.87-1.06, P=0.43 for SS+SL vs. LL). In addition, in the subgroup analysis by ethnicity and cancer type, no significant association was found among Caucasians, African-Americans, prostate cancer, or breast cancer. This current meta-analysis suggested that the poly(A) polymorphism in the VDR gene may not contribute to the risk of cancer. Future studies are needed to validate our findings.
authors.affiliation: West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Jiqiao
authors.initials: J
authors.lastname: Yang
authors.forename: Haichuan
authors.initials: H
authors.lastname: Wang
authors.forename: Tianyuan
authors.initials: T
authors.lastname: Xiong
authors.forename: Hongbo
authors.initials: H
authors.lastname: Zhang
authors.forename: Yaxian
authors.initials: Y
authors.lastname: Ma
authors.forename: Xiaoze
authors.initials: X
authors.lastname: Wang
authors.forename: Jichong
authors.initials: J
authors.lastname: Huang
authors.forename: Liang
authors.initials: L
authors.lastname: Du
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human