title: Haemoglobin SD disease--rare case of jaundice.
abstract: A 15 years old Muslim female presented with moderate anaemia, mild jaundice and hepatosplenomegaly with no history of blood transfusion in the past. Routine examination was suggestive of haemolytic jaundice. High pressure liquid chromatography (HPLC) electrophoresis of the patient's blood showed haemoglobin (Hb) SD disease. As it is a double heterozygous disease, family screening was done. It showed that the father was sickle cell trait. Mother was Hb D trait. Both the brothers were sickle cell trait and the only sister was normal. Hb SD disease is a very rare variety of haemoglobinopathy and the case is presented here due to its rarity.
authors.affiliation: Department of Medicine, RG Kar Medical College, Kolkata.
authors.forename: Udas Chandra
authors.initials: UC
authors.lastname: Ghosh
authors.forename: Krishna
authors.initials: K
authors.lastname: Sen
authors.forename: Atindra
authors.initials: A
authors.lastname: Narayan
authors.forename: Kajal Krishna
authors.initials: KK
authors.lastname: Banik
authors.forename: Pradip Kumar
authors.initials: PK
authors.lastname: Saha
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000175:diagnosis* / Q000235:genetics; D002869:Chromosome Aberrations; D003906:Developing Countries; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D006580:Genetic Carrier Screening; D005820:Genetic Testing; D006451:Hemoglobin, Sickle; D006452:Hemoglobinometry; D006453:Hemoglobinopathies / Q000175:diagnosis* / Q000235:genetics; D006455:Hemoglobins, Abnormal; D006720:Homozygote; D006801:Humans; D007565:Jaundice / Q000175:diagnosis / Q000235:genetics; D008111:Liver Function Tests; D012805:Sickle Cell Trait / Q000097:blood / Q000175:diagnosis* / Q000235:genetics
chemical_list: D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; C032001:hemoglobin D