title: Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF.
abstract: Stable IspF substrate analogs were synthesized. In the presence of substrate analogs, theE. coliIspF-MEP complex shows activities distinct from IspF, and bisphosphonates (BP) behave differently than their diphosphate (DP) counterparts. Bisphosphonate analogs activate and/or stabilize IspF, and only the closest structural substrate analog weakly inhibits the IspF-MEP complex.
authors.affiliation: Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
authors.forename: J Kipchirchir
authors.initials: JK
authors.lastname: Bitok
authors.forename: Caren Freel
authors.initials: CF
authors.lastname: Meyers