title: Changes in the prevalence of the measles, rubella, varicella-zoster, and mumps virus antibody titers in Japanese pregnant women.
abstract: In the present study, immunity against infectious diseases, which are capable of influencing both the mother and fetus during pregnancy and the infant in the postnatal period, were assessed in pregnant women to elucidate the necessity of vaccination during the childbearing age. It was determined that there was a trend of increases in the proportion of patients that had low antibody titers observed at a young age. Overall, after adjusting for age, low antibody titers of measles (≤ 4 via the neutralization test [NT]), rubella (≤ 16 via the hemagglutination inhibition [HI]), and varicella and mumps (plus minus or negative on the enzyme-linked immunosorbent assay [EIA]) indicated that the rates of necessity for vaccination against measles, rubella, varicella, and mumps were 27.6%, 16.1%, 3.9%, and 23.8%, respectively. In Japan, acquired immunity for measles, rubella, and mumps was dependent on vaccination, whereas acquired immunity for varicella was dependent on natural infection. We recommend that women be vaccinated after delivery, as these vaccines are live, and thereby, are contraindicated during pregnancy.
authors.affiliation: National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Masachi
authors.initials: M
authors.lastname: Hanaoka
authors.forename: Michi
authors.initials: M
authors.lastname: Hisano
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Watanabe
authors.forename: Kana
authors.initials: K
authors.lastname: Sugawara
authors.forename: Yukari
authors.initials: Y
authors.lastname: Kambe
authors.forename: Eriko
authors.initials: E
authors.lastname: Kanda
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sago
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kato
authors.forename: Koushi
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002644:Chickenpox / Q000276:immunology / Q000517:prevention & control; D019433:Chickenpox Vaccine / Q000008:administration & dosage / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006562:Herpes Zoster; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008457:Measles / Q000276:immunology / Q000517:prevention & control; D008459:Measles virus / Q000276:immunology*; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000276:immunology; D009107:Mumps / Q000276:immunology / Q000517:prevention & control; D009109:Mumps virus / Q000276:immunology*; D009500:Neutralization Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control*; D015995:Prevalence; D012409:Rubella / Q000276:immunology / Q000517:prevention & control; D012412:Rubella virus / Q000276:immunology*; D014611:Vaccination; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D019433:Chickenpox Vaccine; D022542:Measles-Mumps-Rubella Vaccine