title: T wave alternans in experimental myocardial infarction: time course and predictive value for the assessment of myocardial damage.
abstract: BACKGROUND
  T-wave alternans (TWA) is associated with prognosis after myocardial infarction (MI), however its link to the extent of ischemic injury has not been clarified. We analyzed the course of TWA and its relation to myocardial damage in experimental myocardial infarction.
  
  
  METHODS
  In 21 pigs, infarction was induced by 40-minute long balloon inflation in LAD under continuous 12-lead ECG monitoring. TWA was assessed in a 32-beat sliding window, using periodic component analysis and the Laplacian Likelihood Ratio method. Myocardium at risk (MaR) and infarct size (IS) were evaluated by SPECT and magnetic resonance imaging respectively.
  
  
  RESULTS
  TWA appeared at 7.2±4.5minutes of occlusion, reached its maximum at 12.7±6.3 and lasted until 26.5±9.2minutes. The maximal level of TWA was associated with both MaR (r=0.499, p=0.035) and IS (r=0.65, p=0.004).
  
  
  CONCLUSIONS
  TWA magnitude is associated with both MaR and IS in experiment, which encourages further studies in clinical settings.
authors.affiliation: Department of Cardiology, Lund University, Lund, Sweden; Federal Centre of Heart, Blood and Endocrinology, St. Petersburg, Russia. marina.demidova@med.lu.se
authors.forename: Marina M
authors.initials: MM
authors.lastname: Demidova
authors.forename: Alba
authors.initials: A
authors.lastname: Martín-Yebra
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Martínez
authors.forename: Violeta
authors.initials: V
authors.lastname: Monasterio
authors.forename: Sasha
authors.initials: S
authors.lastname: Koul
authors.forename: Jesper
authors.initials: J
authors.lastname: van der Pals
authors.forename: Daniel
authors.initials: D
authors.lastname: Romero
authors.forename: Pablo
authors.initials: P
authors.lastname: Laguna
authors.forename: David
authors.initials: D
authors.lastname: Erlinge
authors.forename: Pyotr G
authors.initials: PG
authors.lastname: Platonov
mesh_terms: D000818:Animals; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004562:Electrocardiography / Q000379:methods*; D006339:Heart Rate; D009203:Myocardial Infarction / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D017682:Myocardial Stunning / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine