title: Changes in plasma ghrelin and serum leptin levels after Cisplatin-based transcatheter arterial infusion chemotherapy for hepatocellular carcinoma.
abstract: Background and Objective. Cisplatin-based chemotherapy is widely recognized to cause severe gastrointestinal disorders like nausea, vomiting, and appetite loss. The aim of this study was to assess whether cisplatin-based transcatheter arterial infusion (TAI) chemotherapy reduces plasma ghrelin levels and food intake in hepatocellular carcinoma (HCC) patients. Methods. Seventeen patients with HCC who underwent cisplatin-based TAI chemotherapy (80-100 mg/body) were enrolled in this study. Changes in peptide hormones, including ghrelin and leptin, as well as cytokines, were measured before and after chemotherapy. Appetite was evaluated by visual analog scale (VAS) and food intake was scored by eleven stages (0-10). Results. Appetite and food intake were significantly decreased after chemotherapy (P < 0.05). Plasma acylated ghrelin levels before therapy and at day 1, day 7, and day 14 after chemotherapy were 10.4 ± 7.2, 4.7 ± 4.7, 11.7 ± 8.9, and 9.3 ± 6.6 fmol/mL, respectively. The level on day 1 was decreased significantly (P < 0.05). In contrast, the levels of leptin, granulocyte colony-stimulating factor (G-CSF), and monocyte chemotactic protein-1 (MCP-1) on day 1 were increased significantly (P < 0.05). Conclusions. TAI for HCC reduced plasma acylated ghrelin levels, appetite, and food intake significantly. In addition, it increased serum leptin levels.
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan ; Department of Endoscopic Diagnostics and Therapeutics, Chiba University Hospital, Chiba City 260-8670, Japan.
authors.forename: Tomoaki
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authors.lastname: Matsumura
authors.forename: Makoto
authors.initials: M
authors.lastname: Arai
authors.forename: Masaharu
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Kentaro
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authors.lastname: Sudo
authors.forename: Kazuyoshi
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authors.lastname: Nakamura
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Katsuno
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kanai
authors.forename: Taketo
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokosuka