title: De novo synthesis of D- and L-fucosamine containing disaccharides.
abstract: The availability of rare monosaccharides that cannot be isolated from natural sources is currently limiting the access to the synthesis and the biological evaluation of complex bacterial cell-surface glycans. Here, we report the synthesis of D- and L-fucosamine building blocks by a de novo approach from L- and D-Garner aldehydes. These differentially protected monosaccharide building blocks were utilized to prepare disaccharides present on the surface of Pseudomonas aeruginosa bacteria.
authors.affiliation: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany.
authors.forename: Daniele
authors.initials: D
authors.lastname: Leonori
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
keywords: de novo synthesis; fucosamine; glycan; pseudomonas aeruginosa; vaccine