title: Chromosome segregation: disarming the protector.
abstract: One of the key features of meiosis is that shugoshin in complex with protein phosphatase 2A (PP2A) protects centromeric cohesin during meiosis I, but not during meiosis II. A new model suggests that a PP2A inhibitor mediates deprotection of centromeric cohesin during meiosis II.
authors.affiliation: Max F. Perutz Laboratories, Department of Chromosome Biology, University of Vienna, Dr. Bohr-Gasse 1, 1030 Vienna, Austria.
authors.forename: Swastika
authors.initials: S
authors.lastname: Sanyal
authors.forename: Ines
authors.initials: I
authors.lastname: Kovacikova
authors.forename: Juraj
authors.initials: J
authors.lastname: Gregan
mesh_terms: D000818:Animals; D002938:Ciona intestinalis / Q000502:physiology*; D008297:Male; D008540:Meiosis; D054648:Protein Phosphatase 2 / Q000378:metabolism*; D012854:Sister Chromatid Exchange; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; D054648:Protein Phosphatase 2