title: Comparative study on in vitro activities of citral, limonene and essential oils from Lippia citriodora and L. alba on yellow fever virus.
abstract: The aim of this study was to compare the antiviral activities in vitro of citral, limonene and essential oils (EOs) from Lippia citriodora and L. alba on the replication of yellow fever virus (YFV). Citral and EOs were active before and after virus adsorption on cells; IC50 values were between 4.3 and 25 microg/mL and SI ranged from 1.1 to 10.8. Results indicate that citral could contribute to the antiviral activity of the L. citriodora EO. Limonene was not active and seemed to play an insignificant role in the antiviral activity of the examined EOs.
authors.affiliation: Centro Nacional de Investigaciones para la Agroindustrialización de Especies Vegetales Aromáticas y Medicinales Tropicales (CENIVAM), Universidad Industrial de Santander, Bucaramanga, Colombia.
authors.forename: Luz Angela
authors.initials: LA
authors.lastname: Gómez
authors.forename: Elena
authors.initials: E
authors.lastname: Stashenko
authors.forename: Raquel Elvira
authors.initials: RE
authors.lastname: Ocazionez
mesh_terms: D000080462:Acyclic Monoterpenes; D000998:Antiviral Agents / Q000494:pharmacology*; D053138:Cyclohexenes / Q000494:pharmacology*; D000077222:Limonene; D032411:Lippia / Q000737:chemistry*; D039821:Monoterpenes / Q000494:pharmacology*; D009822:Oils, Volatile / Q000494:pharmacology*; D013729:Terpenes / Q000494:pharmacology*; D015005:Yellow fever virus / Q000187:drug effects*
chemical_list: D000080462:Acyclic Monoterpenes; D000998:Antiviral Agents; D053138:Cyclohexenes; D039821:Monoterpenes; D009822:Oils, Volatile; D013729:Terpenes; D000077222:Limonene; C007076:citral