title: Neuroendocrine tumor in liver with positive ACTH receptor: a case report.
abstract: A rare case of possible primary ectopic adrenocorticotropic hormone (ACTH)-producing tumor in the liver mimicking a liver hemangioma is reported. A 9-year-old boy, with Cushing syndrome, was referred for the assessment of ectopic ACTH-producing tumor. Ultrasound, CT scan, and MRI of the abdomen revealed a liver lesion suggestive of a hemangioma. (111)In-octreotide scintigraphy revealed focal activity in the liver, indicative of a somatostatin-positive lesion. (99m)Tc-labeled RBC scintigraphy was negative for hemangioma. After surgical resection of the tumor, the cortisol level converted to a normal range indicative of a rare possible primary ACTH-producing tumor in the liver, which was confirmed by histopathology.
authors.affiliation: Department of Diagnostic Imaging, Division of Nuclear Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Mohamad
authors.initials: M
authors.lastname: El Zein
authors.forename: Reza
authors.initials: R
authors.lastname: Vali
authors.forename: Martin
authors.initials: M
authors.lastname: Charron
authors.forename: David
authors.initials: D
authors.lastname: Manson
authors.forename: Kusiel
authors.initials: K
authors.lastname: Perlman
authors.forename: Amer
authors.initials: A
authors.lastname: Shammas
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D002648:Child; D003480:Cushing Syndrome / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D008297:Male; D018358:Neuroendocrine Tumors / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D018043:Receptors, Corticotropin / Q000378:metabolism*
chemical_list: D018043:Receptors, Corticotropin; D000324:Adrenocorticotropic Hormone