title: Adoptive T-cell transfer combined with a single low dose of total body irradiation eradicates breast tumors.
abstract: The major objectives of tumor vaccination are to induce the regression of established tumors and to favor the establishment of long-lasting tumor-specific immunity, capable of protecting the host from relapse. Immunotherapeutic strategies such as the administration of tumor-associated antigenic peptides offer one means to boost preexisting antitumor CD8+T cell immunity. Our recent work reveals that established breast tumors are rejected and tumor recurrence prevented when low-dose irradiation is combined with the adoptive transfer of Mammaglobin A epitope-specific CD8+T cells.
authors.affiliation: Department of Immunology and Microbiology; Rush University Medical Center; Chicago, IL USA.
authors.forename: Nadine M
authors.initials: NM
authors.lastname: Lerret
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Marzo
keywords: CD8 T cells; Mammaglobin-A; adoptive T-cell therapy; low dose irradiation; tumor eradication