title: Zephgrabetaine: a new betaine-type amaryllidaceae alkaloid from Zephyranthes grandiflora.
abstract: Zephgrabetaine (1), a new betaine type Amaryllidaceae alkaloid, along with seven known alkaloids, lycorine, galanthine, lycoramine, hamayne, haemanthamine, tortuosine, and ungeremine were isolated from the bulbs of Zephyranthes grandiflora and their structures elucidated by spectroscopic data analysis. The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary cells). A dose dependent cytotoxic effect was exhibited by all the alkaloids on these two cancer cell lines with prominent activity of lycorine and haemanthamine.
authors.affiliation: Natural Plant Products Division, CSIR - Institute of Himalayan Bioresource Technology, Post Box No. 6, Palampur 176 061 (HP), India.
authors.forename: Deepali
authors.initials: D
authors.lastname: Katoch
authors.forename: Dharmesh
authors.initials: D
authors.lastname: Kumar
authors.forename: Upendra
authors.initials: U
authors.lastname: Sharma
authors.forename: Neeraj
authors.initials: N
authors.lastname: Kumar
authors.forename: Yogendra S
authors.initials: YS
authors.lastname: Padwad
authors.forename: Brij
authors.initials: B
authors.lastname: Lal
authors.forename: Bikram
authors.initials: B
authors.lastname: Singh
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001622:Betaine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008647:Mesocricetus; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D047151:Amaryllidaceae Alkaloids; C580696:zephgrabetaine; D001622:Betaine