title: First case report of anaphylaxis caused by Rajgira seed flour (Amaranthus paniculatus) from India: a clinico-immunologic evaluation.
abstract: The prevalence of food allergy is reported to be 3-4% in adults and about 6% in children. However food allergy across different countries accounts for 35-50 % all cases of anaphylaxis to foods. In the present study, we have reported a case of anaphylaxis to Amaranth grain (Amaranthus paniculatus) commonly known as Rajgira (Ramdana) in India. A 60 year old female suffered anaphylaxis after consuming Rajgira seed flour generally consumed during fasting. Food allergy to Amaranth seeds is not reported so far. The patient reported to hospital with complaints of itching in mouth, choking throat, redness and swelling of face and burning abdomen within 5 min of consuming Rajgira flour. Clinical and immunological investigations revealed SPT and oral challenge positivity beside high allergen specific IgE in the serum of the patient. Three IgE binding protein fractions were detected in roasted Rajgira seed flour extract which could be considered to be allergenically important for triggering anaphylaxis.
authors.affiliation: Institute of Genomics and Integrative Biology, Delhi, India.
authors.forename: Ramkrashan
authors.initials: R
authors.lastname: Kasera
authors.forename: P V
authors.initials: PV
authors.lastname: Niphadkar
authors.forename: Aditya
authors.initials: A
authors.lastname: Saran
authors.forename: Chandni
authors.initials: C
authors.lastname: Mathur
authors.forename: A B
authors.initials: AB
authors.lastname: Singh
mesh_terms: D000485:Allergens / Q000276:immunology*; D027721:Amaranthus / Q000009:adverse effects* / Q000737:chemistry; D000707:Anaphylaxis / Q000175:diagnosis* / Q000276:immunology*; D003429:Cross Reactions; D005260:Female; D005433:Flour / Q000009:adverse effects*; D005512:Food Hypersensitivity; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007194:India; D008875:Middle Aged; D010940:Plant Proteins / Q000009:adverse effects / Q000276:immunology; D012639:Seeds / Q000737:chemistry / Q000276:immunology; D012882:Skin Tests
chemical_list: D000485:Allergens; D010940:Plant Proteins; D007073:Immunoglobulin E