title: Quality of life is impaired not only in vitamin D deficient but also in vitamin D-insufficient pre-menopausal women.
abstract: BACKGROUND
  Vitamin D deficiency may be more common in pre-menopausal women than previously thought and it may impair quality of life (QoL).
  
  
  OBJECTIVE
  The aim of this study is to evaluate QoL in pre-menopausal women with vitamin D deficiency and insufficiency.
  
  
  METHODS
  This is a cross-sectional study in which subjects were enrolled between September 1st and November 30th, 2011. Healthy premenopausal women with weakness, fatigue and non-specific pain were assigned into three groups according to their 25- hydroxyvitamin D (25-OHD) levels: ≤20 ng/ml (vitamin D deficient, no.=30), 21-29 ng/ml (vitamin D insufficient, no.=30) and ≥30 ng/ml (vitamin D sufficient, no.=20). Short form-36 (SF- 36) scores, age, calcium (Ca), phosphorus (P), and PTH levels were compared among the groups and correlations of SF-36 scores with age, serum 25-OHD, Ca, P, and PTH were done.
  
  
  RESULTS
  There were significant differences among the groups with regard to PTH (p=0.008), physical component score (p=0.02), mental component score (p=0.035), physical functioning score (p=0.0001), and vitality score (p=0.05). Apart from PTH and physical functioning score, the results were significant when vitamin D-insufficient and -sufficient women were compared. Serum 25-OHD, but not PTH was correlated with some of the scales of SF-36.
  
  
  CONCLUSIONS
  Some components of QoL are impaired not only in vitamin D deficient but also in insufficient pre-menopausal women, and impairment is related to 25-OHD rather than PTH levels.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Ondokuz Mayis University School of Medicine, Kurupelit Samsun 55139, Turkey.
authors.forename: G C
authors.initials: GC
authors.lastname: Ecemis
authors.forename: A
authors.initials: A
authors.lastname: Atmaca
mesh_terms: D000328:Adult; D002118:Calcium / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008593:Menopause; D010281:Parathyroid Hormone / Q000097:blood; D011788:Quality of Life; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000523:psychology
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium