title: Aspirin and heparin as adjuvants during IVF do not improve live birth rates in unexplained implantation failure.
abstract: This study tested the hypothesis that using aspirin and/or heparin as adjuvants in IVF improves the treatment outcome. This retrospective cohort-control study recruited 234 consecutive subjects aged ≤ 44 years who had previously had one or more unsuccessful IVF cycle. All underwent IVF using conventional protocols. The study group received aspirin and/or heparin post embryo transfer until the day of pregnancy test or until 12 weeks of pregnancy. The control group did not receive adjuvant treatment. The outcome measures were live birth, clinical pregnancy and miscarriage rates. The outcomes were compared by chi-squared test and relative-risk analysis. Analysis was performed in 206 subjects. There was no statistically significant difference in the live birth rate (35.0%, 36/103 versus 47.6%, 49/103), clinical pregnancy rate (40.8%, 42/103 versus 53.4%, 55/103) and miscarriage rate (14.3%, 6/42 versus 10.9%, 6/55) between the study group and the control group. The data in this study show that low-dose aspirin and/or heparin as adjuvant therapies during IVF do not improve live birth rates in an unselected group of subfertile women who have previously had one or more unexplained implantation failure following IVF.
authors.affiliation: Nottingham University Research and Treatment Unit in Reproduction (NURTURE), Division of Obstetrics and Gynaecology, School of Clinical Sciences, University of Nottingham, Nottingham, Nottinghamshire NG7 2UH, United Kingdom.
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Akhtar
authors.forename: Hanan
authors.initials: H
authors.lastname: Eljabu
authors.forename: James
authors.initials: J
authors.lastname: Hopkisson
authors.forename: Nick
authors.initials: N
authors.lastname: Raine-Fenning
authors.forename: Siobhan
authors.initials: S
authors.lastname: Quenby
authors.forename: Kannamannadiar
authors.initials: K
authors.lastname: Jayaprakasan
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage*; D001723:Birth Rate; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female; D007248:Infertility, Male; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D006493:Heparin; D001241:Aspirin