title: Evaluation of socket healing in patients undergoing bisphosphonate therapy: experience of a single Institution.
abstract: OBJECTIVE
  To assess the clinical features of exodontias performed in cancer patients who have been receiving intravenous bisphosphonates (BPs).
  
  
  METHODS
  This is a retrospective cohort study using a sample of 20 patients receiving BPs who had 62 teeth extracted. An univariate analysis was applied to calculate socket healing time (HT), comparing among exodontias performed according to cause, such as periodontal disease or caries, type of BP, and use of corticosteroid. In order to analyze the influence of each variable on HT, multiple statistical analyses were performed through logistic multiple regression.
  
  
  RESULTS
  From the 62 tooth extractions performed, 5 exodontias had evolved to 4 sites of bisphosphonate-related osteonecrosis of the jaws (BOJ). Of another 57 exodontias without development of BOJ, HT was significantly better for tooth extraction performed in patients receiving corticosteroid (p= .01), for tooth extracted due to caries (p= .04), and for extractions under pamidronate (p= .03). Sockets after exodontias due to periodontal diseases had OR= 5.22 (95% CI 1.73-133.66, p=0.01) for delayed HT, exodontias performed under corticosteroid use had OR=0.04 (95% CI 0.01-0.40, p<0.001), and exodontias performed under zoledronate had OR=0.31 (95% CI 0.08-1.25, p=0.10).
  
  
  CONCLUSIONS
  Exodontias performed in patients under BP therapy had a low rate of BOJ occurrence. Zoledronate and periodontal diseases influence delayed socket healing. Adjuvant antibiotics could be relevant procedures aimed at reducing the risk of BOJ development.
authors.affiliation: Stomatology Department, Hospital AC Camargo, São Paulo, Brazil.
authors.forename: Gabriel-Fukunaga
authors.initials: GF
authors.lastname: Kato
authors.forename: Rodrigo-Nascimento
authors.initials: RN
authors.lastname: Lopes
authors.forename: Graziella-Chagas
authors.initials: GC
authors.lastname: Jaguar
authors.forename: Ana-Paula
authors.initials: AP
authors.lastname: Silva
authors.forename: Fabio-Abreu
authors.initials: FA
authors.lastname: Alves
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004164:Diphosphonates / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014081:Tooth Extraction; D020390:Tooth Socket; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D004164:Diphosphonates