title: Increasing thyroid-stimulating hormone is associated with impaired glucose metabolism in euthyroid obese children and adolescents.
abstract: BACKGROUND
  Contrasting data exist regarding the relationship between thyroid-stimulating hormone (TSH) and obesity-related risk factors in children. In the present study, we investigated the association between TSH, free T4 (fT4) and cardiometabolic risk factors in euthyroid obese children and adolescents.
  
  
  METHODS
  A retrospective analysis of patient records was performed on data from 703 multi-ethnic obese children and adolescents who visited an obesity-outpatient clinic. We performed anthropometric measurements, an oral glucose tolerance test, and measured serum TSH, fT4 and lipid levels.
  
  
  RESULTS
  A positive association between TSH and the standard deviation score of the body mass index (BMI-Z) was found. After adjustment for ethnicity, sex, pubertal stage and BMI-Z, logistic regression analysis showed significant associations between TSH levels and impaired fasting glucose, impaired glucose tolerance, high total cholesterol, high low-density lipoprotein cholesterol and high triglycerides. No significant associations between fT4 levels and cardiometabolic risk factors were found in linear/logistic regression analysis.
  
  
  CONCLUSIONS
  In our multi-ethnic cohort of euthyroid obese children and adolescents increasing TSH was associated with impaired glucose metabolism and dyslipidemia.
authors.affiliation: Department of Pharmacy and Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands. Nalini.Radhakishum@slz.nl
authors.forename: Nalini N E
authors.initials: NN
authors.lastname: Radhakishun
authors.forename: Mariska
authors.initials: M
authors.lastname: van Vliet
authors.forename: Ines A
authors.initials: IA
authors.lastname: von Rosenstiel
authors.forename: Olivier
authors.initials: O
authors.lastname: Weijer
authors.forename: Jos H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: Dees P M
authors.initials: DP
authors.lastname: Brandjes
authors.forename: Michaela
authors.initials: M
authors.lastname: Diamant
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D050171:Dyslipidemias / Q000453:epidemiology / Q000378:metabolism; D005260:Female; D044882:Glucose Metabolism Disorders / Q000453:epidemiology* / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology* / Q000378:metabolism*; D015995:Prevalence; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000378:metabolism*; D055815:Young Adult
chemical_list: D013972:Thyrotropin