title: A map of Alzheimer's disease-signaling pathways: a hope for drug target discovery.
abstract: Alzheimer’s disease (AD) is a complex neurodegenerative condition, and its drug therapy is challenging. To inform AD drug discovery, we developed the “AlzPathway,” a prototype of a comprehensive map of AD-related signaling pathways, from information obtained through studies in the public domain. The AlzPathway provides an integrated platform for systems analyses of AD-signaling pathways and networks.
authors.affiliation: Department of Bioclinical Informatics, Tohoku Medical Megabank Organization, Tohoku University, Sendai-shi, Japan. ogishima@sysmedbio.org
authors.forename: S
authors.initials: S
authors.lastname: Ogishima
authors.forename: S
authors.initials: S
authors.lastname: Mizuno
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: A
authors.initials: A
authors.lastname: Miyashita
authors.forename: R
authors.initials: R
authors.lastname: Kuwano
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: J
authors.initials: J
authors.lastname: Nakaya
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000503:physiopathology*; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy; D015398:Signal Transduction; D049490:Systems Biology