title: BIM, PUMA, and the achilles' heel of oncogene addiction.
abstract: Cancer cells undergo extensive genetic and epigenetic rewiring to support the malignant phenotype, and yet cell survival and proliferation often remain dependent on one or a limited number of driver mutations. This is the concept of oncogene addiction, the elucidation of which has led to substantial progress in therapeutic interventions. However, because resistance mechanisms often emerge, explicating the pathways that connect therapeutic oncogene inactivation to the cell death machinery is critical to exploiting additional synthetic lethal opportunities.
authors.affiliation: Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Quebec H3G 2J7, Canada.
authors.forename: Anne
authors.initials: A
authors.lastname: Roulston
authors.forename: William J
authors.initials: WJ
authors.lastname: Muller
authors.forename: Gordon C
authors.initials: GC
authors.lastname: Shore
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D000072224:Bcl-2-Like Protein 11; D049109:Cell Proliferation; D002470:Cell Survival / Q000235:genetics; D016503:Drug Delivery Systems / Q000379:methods*; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D009857:Oncogenes / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
chemical_list: D051017:Apoptosis Regulatory Proteins; D000072224:Bcl-2-Like Protein 11; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C438378:BBC3 protein, human; C000606775:BCL2L11 protein, human; C508053:ERBB2 protein, human