title: Three cases of intraocular mesectodermal leiomyoma expressing progesterone and androgen receptors.
abstract: OBJECTIVE
  A prospective study identified three patients between 2004 and 2010 with mesectodermal leiomyoma. The study was conducted to analyse the presence or absence of sex steroid hormone receptors in mesectodermal leiomyomas.
  
  
  METHODS
  The clinical features were collated. All three patients had operative procedures to either remove or sample the mesectodermal leiomyomas. The tissue was fixed in formalin and exposed to conventional histological processing. Immunohistochemistry using antibodies to androgen (AR), oestrogen (ER), and progesterone (PR) receptors was performed, followed by stain scoring to assess for expression status.
  
  
  RESULTS
  All three cases were confirmed by histology to be examples of mesectodermal leiomyomas. All three expressed sex steroid hormone receptors. One case expressed both PR and AR, one case PR only and another case AR only. None of the cases expressed ER receptors.
  
  
  CONCLUSIONS
  All three cases displayed some sex steroid hormone receptor expression. This is supportive evidence that sex steroid hormones may have a role in the pathogenesis of this tumour and suggest that it may be amenable to hormonal manipulation therapy, in a manner similar to conventional uterine leiomyomas.
authors.affiliation: Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: H
authors.initials: H
authors.lastname: Quhill
authors.forename: I G
authors.initials: IG
authors.lastname: Rennie
authors.forename: P A
authors.initials: PA
authors.lastname: Rundle
authors.forename: H S
authors.initials: HS
authors.lastname: Mudhar
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015811:Iris Neoplasms / Q000378:metabolism*; D007889:Leiomyoma / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011374:Progesterone / Q000378:metabolism*; D011446:Prospective Studies; D011944:Receptors, Androgen / Q000378:metabolism*; D014604:Uveal Neoplasms / Q000378:metabolism*
chemical_list: D011944:Receptors, Androgen; D011374:Progesterone