title: Ischemic postconditioning may increase serum fetuin-A level in patients with acute ST-segment elevation myocardial infarction undergoing percutaneous intervention.
abstract: BACKGROUND
  Fetuin-A inhibits inflammation and has a protective effect against myocardial ischemia. We investigated the influence of ischemic postconditioning on serum fetuin-A levels and high-sensitive C-reactive protein (hs-CRP) in patients with acute ST-segment elevation myocardial infarction undergoing percutaneous intervention.
  
  
  METHODS
  Forty-five patients undergoing percutaneous coronary intervention (PCI) were randomly assigned to a control (n = 21) or postconditioning (PC, n = 24) group within 90 minutes after admission. After predilatation, in the control group, no intervention was applied in the first 3 minutes of reperfusion, while in the postconditioning group, three cycles of 30-second angioplasty balloon deflation and 30-second inflation were repetitively applied. Blood samples were obtained and assayed for creatine kinase MB (CK-MB), fetuin-A and hs-CRP.
  
  
  RESULTS
  The control group presented with higher peak CK-MB as compared with the PC group (123.67 +/- 44.19 vs. 93.08 +/- 35.29 U/L, p < 0.05). After PCI, PC was associated with a lower level of hs-CRP in comparison with the control group (6.07 +/- 1.35 vs. 7.03 +/- 1.27 mg/L, p < 0.05). Serum fetuin-A levels in the PC group was higher than in the control (161.06 +/- 23.98 mg/L vs. 144.59 +/- 22.76 mg/L, p < 0.05).
  
  
  CONCLUSIONS
  Postconditioning may increase serum fetuin-A levels and decrease high-sensitive C-reactive protein in myocardial infarction patients.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Hebei University, Baoding 071000, China. markliu1@163.com
authors.forename: Sheng-Hui
authors.initials: SH
authors.lastname: Liu
authors.forename: Yu-E
authors.initials: YE
authors.lastname: Huo
authors.forename: Bo-Ying
authors.initials: BY
authors.lastname: Yin
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Li
authors.forename: Yan-Fei
authors.initials: YF
authors.lastname: Wang
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D004562:Electrocardiography; D005260:Female; D006801:Humans; D057775:Ischemic Postconditioning; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology* / Q000601:surgery*; D062645:Percutaneous Coronary Intervention; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D060749:alpha-2-HS-Glycoprotein