title: Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts.
abstract: Rapid thiolate exchange of dimethylarsonium, Me2As(+), is observed between two different thiolate species in solution. NMR is used to characterize the equilibrium constants for interthiol transfer as well the rapid intra molecular conformational dynamics which leads to the coalescence of diastereotopic methyl resonances. These rapid exchange kinetics have important consequences of arsenic's toxicity and pharmacology.
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke St. W. Montreal, H3A 2K6 Canada. scott.bohle@mcgill.ca
authors.forename: D Scott
authors.initials: DS
authors.lastname: Bohle
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Gu
mesh_terms: D001152:Arsenicals / Q000737:chemistry*; D003545:Cysteine / Q000031:analogs & derivatives*; D005978:Glutathione / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D001152:Arsenicals; D013438:Sulfhydryl Compounds; D005978:Glutathione; D003545:Cysteine