title: High serum levels of HIF-1α in psoriatic patients correlate with an over-expression of IL-6.
abstract: Angiogenesis has been considered to be an important step in the initiation and progression of chronic diseases such as psoriasis. The hypoxia inducible factor 1 alpha (HIF-1α), a critical hypoxia-induced factor that regulates angiogenesis has been shown previously to be over-expressed in psoriasis skin both at the mRNA and protein level. In this report we confirm HIF-1α and IL-6 over-expression in psoriatic patients using immunoenzymometric assay and found that the expression of HIF-1α is closely correlated with IL-6 expression (r = 0.61 and p = 0.005), suggesting a close interaction of HIF-1α and IL-6 in the psoriasis immuno-microenvironment. Our findings merit further in vitro and in vivo work before solid suggestions can be made for therapeutic interventions that target HIF-1α pathway and/or IL-6.
authors.affiliation: Department of Biochemistry and Biotechnology, University of Thessaly, Greece. iovasilopoulos@bio.uth.gr
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Vasilopoulos
authors.forename: Fani
authors.initials: F
authors.lastname: Sourli
authors.forename: Efterpi
authors.initials: E
authors.lastname: Zafiriou
authors.forename: Eleni
authors.initials: E
authors.lastname: Klimi
authors.forename: Maria
authors.initials: M
authors.lastname: Ioannou
authors.forename: Zissis
authors.initials: Z
authors.lastname: Mamuris
authors.forename: George
authors.initials: G
authors.lastname: Simos
authors.forename: Giorgos
authors.initials: G
authors.lastname: Koukoulis
authors.forename: Angeliki
authors.initials: A
authors.lastname: Roussaki-Schulze
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood*
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C508600:IL6 protein, human; D015850:Interleukin-6