title: Changes in visceral adiposity and serum cholesterol with a novel viscous polysaccharide in Japanese adults with abdominal obesity.
abstract: OBJECTIVE
  Evidence supports the role of dietary fiber in improving metabolic health. PolyGlycopleX (PGX), a viscous functional polysaccharide improves lipidemia and glycemia in healthy adults. Our objective was to examine the effects of PGX on risk factors associated with the metabolic syndrome in Japanese adults with abdominal obesity.
  
  
  METHODS
  Sixty four subjects assigned to 14 weeks of 15 g day(-1) of PGX or placebo were assessed in a randomized, double-blind, placebo-controlled, parallel group trial. At week 0 and 14, primary outcome measures were serum lipids, abdominal adiposity, glucose tolerance and blood pressure.
  
  
  RESULTS
  Total and LDL cholesterol were reduced at week 14 with PGX but not placebo (P < 0.05). The reduction in waist circumference at week 14 was greater with PGX versus placebo (P < 0.05). In females, abdominal visceral fat was decreased to a greater extent with PGX versus placebo (P < 0.05). While glucose tolerance worsened with placebo over time, PGX reduced glucose total area under the curve from week 0 to 6 (P = 0.039). Serum concentrations of resistin and IL6 increased slightly in placebo and decreased slightly with PGX .
  
  
  CONCLUSIONS
  PGX is a functional fiber that shows promise in reducing risk factors related to the metabolic syndrome in Japanese adults with abdominal obesity.
authors.affiliation: Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada, T2N 1N4; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada, T2N 1N4.
authors.forename: Raylene A
authors.initials: RA
authors.lastname: Reimer
authors.forename: Hideyo
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Lindsay K
authors.initials: LK
authors.lastname: Eller
authors.forename: Michael R
authors.initials: MR
authors.lastname: Lyon
authors.forename: Roland J
authors.initials: RJ
authors.lastname: Gahler
authors.forename: Veronica
authors.initials: V
authors.lastname: Kacinik
authors.forename: Prateek
authors.initials: P
authors.lastname: Juneja
authors.forename: Simon
authors.initials: S
authors.lastname: Wood
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D004043:Dietary Fiber / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015850:Interleukin-6 / Q000097:blood; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000178:diet therapy* / Q000378:metabolism; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D052243:Resistin / Q000097:blood; D012737:Sex Factors; D014783:Viscosity; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D015850:Interleukin-6; D011134:Polysaccharides; D052243:Resistin; D002784:Cholesterol