title: Low-density lipoprotein, its susceptibility to oxidation and the role of lipoprotein-associated phospholipase A2 and carboxyl ester lipase lipases in atherosclerotic plaque formation.
abstract: An increased level of low-density lipoprotein (LDL) is a very well established risk factor of coronary artery disease (CAD). Unoxidized LDL is an inert transport vehicle of cholesterol and other lipids in the body and is thought to be atherogenic. Recently it has been appreciated that oxidized products of LDL are responsible for plaque formation properties previously attributed to the intact particle. The goal of this article is to review the recent understanding of the LDL oxidation pathway. The role of oxidized products and key enzymes (lipoprotein-associated phospholipase A2 and carboxyl ester lipase) are also extensively discussed in the context of clinical conditions.
authors.affiliation: Division of Cardiology-Intensive Therapy, Department of Internal Medicine, Poznan University of Medical Sciences, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Burchardt
authors.forename: Jakub
authors.initials: J
authors.lastname: Zurawski
authors.forename: Bartosz
authors.initials: B
authors.lastname: Zuchowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Kubacki
authors.forename: Dawid
authors.initials: D
authors.lastname: Murawa
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Wiktorowicz
authors.forename: Henryk
authors.initials: H
authors.lastname: Wysocki
keywords: atherosclerosis; carboxyl ester lipase; lipoprotein-associated phospholipase A2; lipoproteins