title: The treatment effect of porous titanium alloy rod on the early stage talar osteonecrosis of sheep.
abstract: Osteonecrosis of the talus (ONT) may severely affect the function of the ankle joint. Most orthopedists believe that ONT should be treated at an early stage, but a concise and effective surgical treatment is lacking. In this study, porous titanium alloy rods were prepared and implanted into the tali of sheep with early-stage ONT (IM group). The curative effect of the rods was compared to treatment by core decompression (DC group). No significant differences in bone reconstruction were observed between the two groups at 1 month after intervention. After 3 months, the macroscopic view of gross specimens of the IM group showed ordinary contours, but the specimens of the DC group showed obvious partial bone defects and cartilage degeneration. Quantitative analysis of the reconstructed trabeculae by micro-CT and histological study suggested that the curative effect of the IM group was superior to that of the DC group at 3 months after intervention. These favorable short-term results of the implantation of porous titanium alloy rods into the tali of sheep with early-stage ONT may provide insight into an innovative surgical treatment for ONT.
authors.affiliation: Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Xiao-Kang
authors.initials: XK
authors.lastname: Li
authors.forename: Chao-Fan
authors.initials: CF
authors.lastname: Yuan
authors.forename: Jun-Lin
authors.initials: JL
authors.lastname: Wang
authors.forename: Yong-Quan
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000497:Alloys; D000818:Animals; D000843:Ankle Joint / Q000473:pathology / Q000601:surgery; D005260:Female; D019637:Orthopedic Procedures; D010020:Osteonecrosis / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D016062:Porosity; D013628:Talus / Q000473:pathology*; D014025:Titanium; D014057:Tomography, X-Ray Computed
chemical_list: D000497:Alloys; D014025:Titanium