title: Modeling solid-state transformations occurring in dissolution testing.
abstract: Changes in the solid-state form can occur during dissolution testing of drugs. This can often complicate interpretation of results. Additionally, there can be several mechanisms through which such a change proceeds, e.g. solvent-mediated transformation or crystal growth within the drug material itself. Here, a mathematical model was constructed to study the dissolution testing of a material, which undergoes such changes. The model consisted of two processes: the recrystallization of the drug from a supersaturated liquid state caused by the dissolution of the more soluble solid form and the crystal growth of the stable solid form at the surface of the drug formulation. Comparison to experimental data on theophylline dissolution showed that the results obtained with the model matched real solid-state changes and that it was able to distinguish between cases where the transformation was controlled either by solvent-mediated crystallization or solid-state crystal growth.
authors.affiliation: Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, 00014 University of Helsinki, Finland. timo.laaksonen@helsinki.fi
authors.forename: Timo
authors.initials: T
authors.lastname: Laaksonen
authors.forename: Jaakko
authors.initials: J
authors.lastname: Aaltonen
mesh_terms: D003198:Computer Simulation; D003460:Crystallization; D004355:Drug Stability; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013806:Theophylline / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations; D012997:Solvents; D013806:Theophylline