title: Anesthesia for in utero repair of myelomeningocele.
abstract: Recently published results suggest that prenatal repair of fetal myelomeningocele is a potentially preferable alternative when compared to postnatal repair. In this article, the pathology of myelomeningocele, unique physiologic considerations, perioperative anesthetic management, and ethical considerations of open fetal surgery for prenatal myelomeningocele repair are discussed. Open fetal surgeries have many unique anesthetic issues such as inducing profound uterine relaxation, vigilance for maternal or fetal blood loss, fetal monitoring, and possible fetal resuscitation. Postoperative management, including the requirement for postoperative tocolysis and maternal analgesia, are also reviewed. The success of intrauterine myelomeningocele repair relies on a well-coordinated multidisciplinary approach. Fetal surgery is an important topic for anesthesiologists to understand, as the number of fetal procedures is likely to increase as new fetal treatment centers are opened across the United States.
authors.affiliation: Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
authors.forename: Marla
authors.initials: M
authors.lastname: Ferschl
authors.forename: Robert
authors.initials: R
authors.lastname: Ball
authors.forename: Hanmin
authors.initials: H
authors.lastname: Lee
authors.forename: Mark D
authors.initials: MD
authors.lastname: Rollins
mesh_terms: D000328:Adult; D000698:Analgesia; D000758:Anesthesia / Q000379:methods*; D005260:Female; D046128:Fetal Therapies / Q000941:ethics; D005333:Fetus / Q000502:physiology / Q000601:surgery*; D005865:Gestational Age; D006801:Humans; D007430:Intraoperative Care; D008591:Meningomyelocele / Q000000981:diagnostic imaging / Q000601:surgery*; D011182:Postoperative Care; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011300:Preoperative Care; D016135:Spinal Dysraphism / Q000000981:diagnostic imaging / Q000601:surgery*; D014463:Ultrasonography