title: Investigation of oxidative stress markers in essential hypertension.
abstract: BACKGROUND
  The main goal of this study was to evaluate ischemia modified albumin (IMA), total antioxidant status (TAS), and total oxidant status (TOS) levels in treated essential hypertensive patients and to compare them with levels of normotensive subjects.
  
  
  METHODS
  In 45 hypertensive and 30 control subjects, serum levels of IMA were determined manually using a spectrophotometric Co(II)-albumin binding assay. TAS and TOS levels were evaluated spectrophotometrically. Lipid profile was estimated by routine methods.
  
  
  RESULTS
  Hypertensive patients had significantly higher levels of TOS and IMA (p = 0.020 and p = 0.034, respectively) and lower levels of TAS (p = 0.016) in comparison with control subjects. Serum levels of TAS were negatively correlated with TOS and IMA levels in the patient group. Serum levels of TOS were also positively correlated with IMA levels. There was no significant correlation between blood pressure and TAS, TOS, and IMA levels.
  
  
  CONCLUSIONS
  Our results showed higher levels of IMA in hypertensive patients. We suggest that higher levels of IMA may result from increased oxidative stress and decreased antioxidant status in hypertensive patients.
authors.affiliation: Necmettin Erbakan University, Meram Medical Faculty, Department of Biochemistry, Meram/Konya, Turkey. aysuntoker@gmail.com
authors.forename: Aysun
authors.initials: A
authors.lastname: Toker
authors.forename: Idris
authors.initials: I
authors.lastname: Mehmetoglu
authors.forename: F Humeyra
authors.initials: FH
authors.lastname: Yerlikaya
authors.forename: Suleyman
authors.initials: S
authors.lastname: Nergiz
authors.forename: Sevil
authors.initials: S
authors.lastname: Kurban
authors.forename: Hasan
authors.initials: H
authors.lastname: Gok
mesh_terms: D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers