title: Protective effect of a marine polyphenol, dieckol against carbon tetrachloride-induced acute liver damage in mouse.
abstract: In this study, the hepatoprotective effect of dieckol on carbon tetrachloride (CCl4) induced hepatic damages in ICR mice liver was investigated. Mice were randomly divided into 4 groups such as saline treated (negative control), CCl4 treated (positive control), CCl4+dieckol (5mg/kg mouse) and CCl4+dieckol (25mg/kg mouse), respectively. The body weights and survival rates of mice, followed by dieckol treatments were significantly increased compared to the positive control. The level of GOT, GPT and MDA in the serum of the dieckol treated groups were reduced dose dependently than the control, significantly. The antioxidant enzymes including CAT, and GSH-px levels were increased significantly compared to the positive control. However, no significant differences were observed on hepatic histophathological analysis in dieckol treated groups dose dependently. Down-regulation of Bax and up-regulation of Bcl-xl protein expressions were observed in liver tissues of the dieckol administered groups. These results suggested that, dieckol can be developed as a therapeutic agent for liver disease by oxidative stress.
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Min-Cheol
authors.initials: MC
authors.lastname: Kang
authors.forename: Sung-Myung
authors.initials: SM
authors.lastname: Kang
authors.forename: Ginnae
authors.initials: G
authors.lastname: Ahn
authors.forename: Kil-Nam
authors.initials: KN
authors.lastname: Kim
authors.forename: Nalae
authors.initials: N
authors.lastname: Kang
authors.forename: Kalpa W
authors.initials: KW
authors.lastname: Samarakoon
authors.forename: Myung-Cheol
authors.initials: MC
authors.lastname: Oh
authors.forename: Jung-Suck
authors.initials: JS
authors.lastname: Lee
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002251:Carbon Tetrachloride; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D000459:Phaeophyceae / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry; D059808:Polyphenols; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000378:metabolism; D051020:bcl-X Protein / Q000378:metabolism
chemical_list: C494827:Bax protein, mouse; C494812:Bcl2l1 protein, mouse; D001572:Benzofurans; D010936:Plant Extracts; D059808:Polyphenols; D020011:Protective Agents; D017392:Thiobarbituric Acid Reactive Substances; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein; C503840:dieckol; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase