title: Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks.
abstract: Monocyte/macrophages are important players in orchestrating the immune response as well as connecting innate and adaptive immunity. Myelopoiesis and monopoiesis are characterized by the interplay between expansion of stem/progenitor cells and progression towards further developed (myelo)monocytic phenotypes. In response to a variety of differentiation-inducing stimuli, various prominent signaling pathways are activated. Subsequently, specific transcription factors are induced, regulating cell proliferation and maturation. This review article focuses on the integration of signaling modules and transcriptional networks involved in the determination of monocytic differentiation.
authors.affiliation: Institute of Clinical Chemistry, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany, huber.rene@mh-hannover.de.
authors.forename: René
authors.initials: R
authors.lastname: Huber
authors.forename: Daniel
authors.initials: D
authors.lastname: Pietsch
authors.forename: Johannes
authors.initials: J
authors.lastname: Günther
authors.forename: Bastian
authors.initials: B
authors.lastname: Welz
authors.forename: Nico
authors.initials: N
authors.lastname: Vogt
authors.forename: Korbinian
authors.initials: K
authors.lastname: Brand
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D014157:Transcription Factors