title: Identification of non-volatile compounds and their migration from hot melt adhesives used in food packaging materials characterized by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.
abstract: The identification of unknown non-volatile migrant compounds from adhesives used in food contact materials is a very challenging task because of the number of possible compounds involved, given that adhesives are complex mixtures of chemicals. The use of ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-MS/QTOF) is shown to be a successful tool for identifying non-targeted migrant compounds from two hot melt adhesives used in food packaging laminates. Out of the seven migrants identified and quantified, five were amides and one was a compound classified in Class II of the Cramer toxicity. None of the migration values exceeded the recommended Cramer exposure values.
authors.affiliation: Analytical Chemistry Department, GUIA Group, I3A, EINA, University of Zaragoza, Zaragoza, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Vera
authors.forename: Elena
authors.initials: E
authors.lastname: Canellas
authors.forename: Cristina
authors.initials: C
authors.lastname: Nerín
mesh_terms: D000269:Adhesives / Q000032:analysis* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D018857:Food Packaging; D006358:Hot Temperature; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D053719:Tandem Mass Spectrometry / Q000379:methods*; D044366:Transition Temperature; D014835:Volatilization
chemical_list: D000269:Adhesives