title: Childhood headache and H. pylori--a possible association.
abstract: BACKGROUND
  The prevalence of Helicobacter pylori is thought to be about 40% in developed countries. However, rates are difficult to determine due to many cases being asymptomatic.
  
  
  OBJECTIVE
  We present a case study in which eradication of H. pylori infection in a child, aged 7 years, was followed rapidly by resolution of the patient's recurrent headaches as well as gastrointestinal symptoms. Relevant literature regarding a possible association between H. pylori infection and migraine is discussed.
  
  
  CONCLUSIONS
  Migraine is the most common cause of recurrent headaches in children. Previous reports have suggested a possible association between H. pylori infection and migraine. In the case study presented, H. pylori infection may have been associated with the child's recurrent headaches. Further research is required to confirm these anecdotal findings and to provide guidance for clinicians on whether recurrent headache in childhood is an indication for testing for H. pylori infection with a (13)C-urea breath test and, if necessary, treatment with triple therapy.
authors.affiliation: Discipline of Paediatrics, Sydney Medical School - Nepean, University of Sydney, New South Wales, Australia. l.bradbeer@gmail.com
authors.forename: Lucy
authors.initials: L
authors.lastname: Bradbeer
authors.forename: Swetha
authors.initials: S
authors.lastname: Thakkar
authors.forename: Anthony
authors.initials: A
authors.lastname: Liu
authors.forename: Ralph
authors.initials: R
authors.lastname: Nanan
mesh_terms: D015746:Abdominal Pain / Q000150:complications* / Q000209:etiology; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D017291:Clarithromycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006261:Headache / Q000150:complications* / Q000209:etiology; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D000658:Amoxicillin; D017291:Clarithromycin