title: Urinary determination of 2-isopropyl-4-methyl-6-hydroxypyrimidine in case of non fatal poisoning with diazinon.
abstract: We reported one non fatal case (42 month old boy) of intoxication with diazinon following accidental ingestion. Diazinon and three of its metabolites (2 common metabolites with other organophosphate pesticides: diethylphosphate and diethylthiophosphate; one specific metabolite: 2-isopropyl-4-methyl-6-hydroxypyrimidine) were determined in serum and in urine, respectively, using three liquid chromatography-tandem mass spectrometry methods. Diazinon was detected in serum while its metabolites were detected in urine. The concentrations of diazinon and its common metabolites were compared to concentrations previously described in literature in the same intoxication context and were discussed. The concentration of the specific metabolite was compared to concentrations highlighted in occupational exposure, because to the best of our knowledge, we reported here the first urinary concentration of this metabolite in an acute intoxication context.
authors.affiliation: CHU Dupuytren, Department of Pharmacology and Toxicology, 87042 Limoges, France. sylvain.dulaurent@unilim.fr
authors.forename: S
authors.initials: S
authors.lastname: Dulaurent
authors.forename: J-M
authors.initials: JM
authors.lastname: Gaulier
authors.forename: A
authors.initials: A
authors.lastname: Blanc-Lapierre
authors.forename: L
authors.initials: L
authors.lastname: Imbert
authors.forename: G
authors.initials: G
authors.lastname: Lachâtre
mesh_terms: D000059:Accidents; D002675:Child, Preschool; D002853:Chromatography, Liquid; D003976:Diazinon / Q000008:administration & dosage / Q000097:blood / Q000652:urine*; D053593:Forensic Toxicology; D006801:Humans; D007306:Insecticides / Q000008:administration & dosage / Q000097:blood / Q000652:urine*; D057230:Limit of Detection; D008297:Male; D011743:Pyrimidines / Q000652:urine*; D053719:Tandem Mass Spectrometry
chemical_list: D007306:Insecticides; D011743:Pyrimidines; C009991:G 27550; D003976:Diazinon