title: Synthesis, bifunctionalization, and remarkable adsorption performance of benzene-bridged periodic mesoporous organosilicas functionalized with high loadings of carboxylic acids.
abstract: Highly ordered benzene-bridged periodic mesoporous organosilicas (PMOs) that were functionalized with exceptionally high loadings of carboxylic acid groups (COOH), up to 80 mol % based on silica, have been synthesized and their use as adsorbents for the adsorption of methylene blue (MB), a basic dye pollutant, and for the loading and release of doxorubicin (DOX), an anticancer drug, is demonstrated. These COOH-functionalized benzene-silicas were synthesized by the co-condensation of 1,4-bis(triethoxysilyl) benzene (BTEB) and carboxyethylsilanetriol sodium salt (CES), an organosilane that contained a carboxylic acid group, in the presence of non-ionic oligomeric surfactant Brij 76 in acidic medium. The materials thus obtained were characterized by a variety of techniques, including powder X-ray diffraction (XRD), nitrogen-adsorption/desorption isotherms, TEM, and (13)C and (29)Si solid-state NMR spectroscopy. Owing to the exceptionally high loadings of COOH groups, their high surface areas, and possible π-π-stacking interactions, these adsorbents have very high adsorption capacities and extremely rapid adsorption rates for MB removal and for the controlled loading/release of DOX, thus manifesting their great potential for environmental and biomedical applications.
authors.affiliation: Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Sec. 2, Cheng-Kung Rd, Nei-Hu Dist, Taipei 11490, Taiwan, ROC.
authors.forename: Hao-Yiang
authors.initials: HY
authors.lastname: Wu
authors.forename: Fa-Kuen
authors.initials: FK
authors.lastname: Shieh
authors.forename: Hsien-Ming
authors.initials: HM
authors.lastname: Kao
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Chen
authors.forename: Juti Rani
authors.initials: JR
authors.lastname: Deka
authors.forename: Shih-Hsiang
authors.initials: SH
authors.lastname: Liao
authors.forename: Kevin C-W
authors.initials: KC
authors.lastname: Wu
mesh_terms: D000327:Adsorption; D001555:Benzene Derivatives / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D008751:Methylene Blue / Q000032:analysis* / Q000737:chemistry; D008956:Models, Chemical; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D016062:Porosity; D014961:X-Ray Diffraction
chemical_list: D001555:Benzene Derivatives; D002264:Carboxylic Acids; D017646:Organosilicon Compounds; D004317:Doxorubicin; D008751:Methylene Blue