title: Retinoic acid-producing DCs and gut-tropic FOXP3+regulatory T cells in the induction of oral tolerance.
abstract: The systemic unresponsiveness of the immune system to orally administered antigens is known as oral tolerance. Recent findings describe a new step for the induction of oral tolerance, consisting in the homing of FOXP3+regulatory T cells to the small bowel and the local acquisition of full immunosuppressive capacities, a process in which retinoic acid-producing dendritic cells might play a crucial role.
authors.affiliation: Gastrointestinal Unit; Massachusetts General Hospital/Harvard Medical School; Boston, MA USA.
authors.forename: Eduardo J
authors.initials: EJ
authors.lastname: Villablanca
keywords: FOXP3; dendritic cells; gut homing; oral tolerance; retinoic acid