title: Prohibitin ligands in cell death and survival: mode of action and therapeutic potential.
abstract: Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell survival, metabolism, and inflammation. Several drugs that target PHBs have been identified and evaluated for various clinical applications. Preclinical and clinical studies indicate that these PHB ligands may be useful in oncology, cardiology, and neurology, as well as against obesity. This review covers the physiological role of PHBs in health and diseases and current developments concerning PHB ligands.
authors.affiliation: Therapeutic Innovation Laboratory UMR 7200, CNRS/Université de Strasbourg, Faculté de Pharmacie, 67401 Illkirch Cedex, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Thuaud
authors.forename: Nigel
authors.initials: N
authors.lastname: Ribeiro
authors.forename: Canan G
authors.initials: CG
authors.lastname: Nebigil
authors.forename: Laurent
authors.initials: L
authors.lastname: Désaubry
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004194:Disease; D055808:Drug Discovery; D006801:Humans; D008024:Ligands; D000091402:Prohibitins; D012097:Repressor Proteins / Q000378:metabolism*
chemical_list: D008024:Ligands; C000717328:PHB protein, human; D000091402:Prohibitins; D012097:Repressor Proteins