title: Nickel(II) dithiocarbamate complexes containing sulforhodamine B as fluorescent probes for selective detection of nitrogen dioxide.
abstract: We synthesized complexes of Ni(II) with dithiocarbamate ligands derived from the ortho and para isomers of sulforhodamine B fluorophores and demonstrated they are highly selective in reactions with nitrogen dioxide (NO2). Compared with the para isomer, the ortho isomer showed a much greater fluorescence increase upon reaction with NO2, which led to oxidation and decomplexation of the dithiocarbamate ligand from Ni(II). We applied this probe for visual detection of 1 ppm NO2 in the gas phase and fluorescence imaging of NO2 in macrophage cells treated with a nitrogen dioxide donor.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Saarangan
authors.initials: S
authors.lastname: Krishnakumar
authors.forename: Huan
authors.initials: H
authors.lastname: Yu
authors.forename: Srinivas
authors.initials: S
authors.lastname: Ramishetti
authors.forename: Lih-Wen
authors.initials: LW
authors.lastname: Deng
authors.forename: Suhua
authors.initials: S
authors.lastname: Wang
authors.forename: Leaf
authors.initials: L
authors.lastname: Huang
authors.forename: Dejian
authors.initials: D
authors.lastname: Huang
mesh_terms: D000818:Animals; D002460:Cell Line; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009585:Nitrogen Dioxide / Q000032:analysis*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry*; D013859:Thiocarbamates / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D012235:Rhodamines; D013859:Thiocarbamates; C022027:lissamine rhodamine B; D009532:Nickel; D009585:Nitrogen Dioxide