title: Panton-Valentine leukocidin Staphylococcus causing fatal necrotising pneumonia in a young boy.
abstract: Panton-Valentine leukocidin (PVL) toxin producing strains of Staphylococcus aureus are known to cause skin and soft tissue infection. They can also cause necrotising pneumonia in otherwise healthy individuals. Here we report a case of severe, necrotising, haemorrhagic pneumonia in a 12-year-old boy who presented with a four-day history of a sore throat and fever. During his admission he deteriorated and needed full ventilatory support but despite all efforts he died. Postmortem examination lung swabs confirmed the presence of PVL-associated S aureus. There is a need to improve awareness of this disease among medical practitioners as early diagnosis and appropriate management can save lives.
authors.affiliation: Department of Paediatrics, Macclesfield District General Hospital, Macclesfield, UK. shahzadhaider5@gmail.com
authors.forename: Shahzad
authors.initials: S
authors.lastname: Haider
authors.forename: David
authors.initials: D
authors.lastname: Wright
mesh_terms: D001427:Bacterial Toxins / Q000096:biosynthesis; D002648:Child; D005098:Exotoxins / Q000096:biosynthesis; D017809:Fatal Outcome; D006801:Humans; D007956:Leukocidins / Q000096:biosynthesis; D008297:Male; D009336:Necrosis; D011023:Pneumonia, Staphylococcal / Q000473:pathology / Q000628:therapy; D013211:Staphylococcus aureus / Q000378:metabolism
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin