title: Relationship between Serum Levels of OPG and TGF- β with Decreasing Rate of BMD in Native Chinese Women.
abstract: The objective of this study was to investigate the relationship between serum levels of OPG, TGF- β 1, and TGF- β 2 and BMD decrease rate (BDR) in native Chinese women. This cross-sectional study was performed on 465 healthy native Chinese women aged 35-80 years. Serum levels of OPG, TGF- β 1, and TGF- β 2 were determined. BDR was measured by DXA at the posteroanterior spine, hip, and distal forearm. At all skeletal sites tested, there was a negative correlation between BDR and serum levels of both OPG (r = -0.122 to -0.230, all P = 0.007-0.000) and TGF- β 2 (r = -0.100 to -0.173, all P = 0.029-0.000) and a positive correlation between BDR and serum TGF- β 1 (r = 0.245 - 0.365, all P = 0.000). After adjustment for age and BMI, there were no statistically significant correlations between serum levels of OPG or TGF- β 2 and BDR. However, statistically significant correlations between serum TGF- β 1 and BDR at the lumbar spine and ultradistal forearm remained. Multiple linear regression stepwise analysis showed that serum OPG could explain 1.4-3.7% of BDR variation. Serum TGF- β 1 was a positive determinant of BDR and could explain 5.3-13.3% of BDR variation.
authors.affiliation: Institute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, China.
authors.forename: Xi-Yu
authors.initials: XY
authors.lastname: Wu
authors.forename: Yi-Qun
authors.initials: YQ
authors.lastname: Peng
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Xie
authors.forename: Zhi-Feng
authors.initials: ZF
authors.lastname: Sheng
authors.forename: Xiang-Hang
authors.initials: XH
authors.lastname: Luo
authors.forename: Ru-Chun
authors.initials: RC
authors.lastname: Dai
authors.forename: Hou-De
authors.initials: HD
authors.lastname: Zhou
authors.forename: Xian-Ping
authors.initials: XP
authors.lastname: Wu
authors.forename: Er-Yuan
authors.initials: EY
authors.lastname: Liao