title: Radiation-induced spinal cord glioblastoma with cerebrospinal fluid dissemination subsequent to treatment of lymphoblastic lymphoma.
abstract: BACKGROUND
  Radiation-induced glioma arising in the spinal cord is extremely rare. We report a case of radiation-induced spinal cord glioblastoma with cerebrospinal fluid (CSF) dissemination 10 years after radiotherapy for T-cell lymphoblastic lymphoma.
  
  
  METHODS
  A 32-year-old male with a history of T-cell lymphoblastic lymphoma presented with progressive gait disturbance and sensory disturbance below the T4 dermatome 10 years after mediastinal irradiation. Gadolinium-enhanced magnetic resonance (MR) imaging revealed an intramedullary tumor extending from the C6 to the T6 level, corresponding to the previous radiation site, and periventricular enhanced lesions. In this case, the spinal lesion was not directly diagnosed because the patient refused any kind of spinal surgery to avoid worsening of neurological deficits. However, based on a biopsy of an intracranial disseminated lesion and repeated immmunocytochemical examination of CSF cytology, we diagnosed the spinal tumor as a radiation-induced glioblastoma. The patient was treated with radiotherapy plus concomitant and adjuvant temozolomide. Then, the spinal tumor was markedly reduced in size, and the dissemination disappeared.
  
  
  CONCLUSIONS
  We describe our detailed diagnostic process and emphasize the diagnostic importance of immunocytochemical analysis of CSF cytology.
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kikkawa
authors.forename: Satoshi O
authors.initials: SO
authors.lastname: Suzuki
authors.forename: Akira
authors.initials: A
authors.lastname: Nakamizo
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tsuchimochi
authors.forename: Nobuya
authors.initials: N
authors.lastname: Murakami
authors.forename: Tadamasa
authors.initials: T
authors.lastname: Yoshitake
authors.forename: Shinichi
authors.initials: S
authors.lastname: Aishima
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Okubo
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hata
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Amano
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshimoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mizoguchi
authors.forename: Toru
authors.initials: T
authors.lastname: Iwaki
authors.forename: Tomio
authors.initials: T
authors.lastname: Sasaki
keywords: Glioblastoma multiforme; nonHodgkin's lymphoma; radiotherapy; spinal cord