title: Expression of Cyclon/CCDC86, a novel nuclear protein, in the hippocampus of adult non-human primates.
abstract: Cyclon (cytokine-induced protein with coiled-coil domain), also known as CCDC86 (coiled-coil domain-containing protein 86), is a nuclear protein expressed in lymphocytes in mice where it regulates T-cell responses. Here we show that Cyclon/CCDC86 is expressed in the hippocampus of adult macaque monkeys, including both the hippocampus proper (cornu Ammonis) and the dentate gyrus. Cyclon/CCDC86 was localized to neurons and astrocytes in cornu Ammonis, while in the dentate gyrus the protein was also expressed in immature neurons and a very small fraction of proliferating cells. These results point to a novel expression pattern of Cyclon/CCDC86 beyond its currently known immune cell localization.
authors.affiliation: Department of Psychiatry and Medical Psychology, Medical University-Varna, Varna, Bulgaria.
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Shishkov
authors.forename: Trifon
authors.initials: T
authors.lastname: Chervenkov
authors.forename: Tetsumori
authors.initials: T
authors.lastname: Yamashima
authors.forename: Anton B
authors.initials: AB
authors.lastname: Tonchev
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D008251:Macaca; D008840:Microfilament Proteins; D009474:Neurons / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D033921:Vesicular Transport Proteins
chemical_list: D008840:Microfilament Proteins; D009687:Nuclear Proteins; C527550:Ccdc88a protein, mouse; D033921:Vesicular Transport Proteins