title: Metabonomics study of essential hypertension and its chinese medicine subtypes by using gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy.
abstract: A metabonomic study was performed to investigate the metabolic mechanism of essential hypertension and its Chinese medicine subtypes, including "Yin-deficiency and Yang-hyperactivity syndrome" (YDYHS) and "Yin-Yang deficiency syndrome" (YYDS). Plasma samples from 22 healthy volunteers, 31 hypertensive patients with YDYHS, and 29 hypertensive patients with YYDS were analyzed by (1)H-NMR spectroscopy and gas chromatography coupled with mass spectrometry (GC-MS). The three groups were distinctly classified by principal components analysis (PCA) and partial least squares discriminant analysis (PLS-DA). According to identified biomarkers and their related pathways, abnormal glucose metabolism might be the main common pathway from YDYHS to YYDS, and sympathetic nervous system activation would play an important role in the pathogenesis of YDYHS, while a low metabolic rate usually occurred in YYDS.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
authors.forename: Yunlun
authors.initials: Y
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Nie
authors.forename: Haiqiang
authors.initials: H
authors.lastname: Jiang
authors.forename: Jiamao
authors.initials: J
authors.lastname: Lin
authors.forename: Honglei
authors.initials: H
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.forename: Zhengjun
authors.initials: Z
authors.lastname: Qu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Qi
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Zhang