title: Impact of refining the assessment of dietary exposure to cadmium in the European adult population.
abstract: Exposure assessment constitutes an important step in any risk assessment of potentially harmful substances present in food. The European Food Safety Authority (EFSA) first assessed dietary exposure to cadmium in Europe using a deterministic framework, resulting in mean values of exposure in the range of health-based guidance values. Since then, the characterisation of foods has been refined to better match occurrence and consumption data, and a new strategy to handle left-censoring in occurrence data was devised. A probabilistic assessment was performed and compared with deterministic estimates, using occurrence values at the European level and consumption data from 14 national dietary surveys. Mean estimates in the probabilistic assessment ranged from 1.38 (95% CI = 1.35-1.44) to 2.08 (1.99-2.23) µg kg⁻¹ bodyweight (bw) week⁻¹ across the different surveys, which were less than 10% lower than deterministic (middle bound) mean values that ranged from 1.50 to 2.20 µg kg⁻¹ bw week⁻¹. Probabilistic 95th percentile estimates of dietary exposure ranged from 2.65 (2.57-2.72) to 4.99 (4.62-5.38) µg kg⁻¹ bw week⁻¹, which were, with the exception of one survey, between 3% and 17% higher than middle-bound deterministic estimates. Overall, the proportion of subjects exceeding the tolerable weekly intake of 2.5 µg kg⁻¹ bw ranged from 14.8% (13.6-16.0%) to 31.2% (29.7-32.5%) according to the probabilistic assessment. The results of this work indicate that mean values of dietary exposure to cadmium in the European population were of similar magnitude using determinist or probabilistic assessments. For higher exposure levels, probabilistic estimates were almost consistently larger than deterministic counterparts, thus reflecting the impact of using the full distribution of occurrence values to determine exposure levels. It is considered prudent to use probabilistic methodology should exposure estimates be close to or exceeding health-based guidance values.
authors.affiliation: Nutrition and Metabolism Section, International Agency for Research on Cancer-IARC, Lyon, France.
authors.forename: Pietro
authors.initials: P
authors.lastname: Ferrari
authors.forename: Davide
authors.initials: D
authors.lastname: Arcella
authors.forename: Fanny
authors.initials: F
authors.lastname: Heraud
authors.forename: Stefano
authors.initials: S
authors.lastname: Cappé
authors.forename: Stefan
authors.initials: S
authors.lastname: Fabiansson
mesh_terms: D000328:Adult; D002104:Cadmium / Q000633:toxicity*; D004032:Diet; D004781:Environmental Exposure; D005060:Europe; D005506:Food Contamination; D006801:Humans; D011336:Probability; D018570:Risk Assessment
chemical_list: D002104:Cadmium