title: The demyelination neurophysiological criteria can be misleading in Campylobacter jejuni-related Guillain-Barré syndrome.
abstract: OBJECTIVE
  The exclusive association of Campylobacter jejuni infection with the axonal variant of Guillain-Barré syndrome (GBS) is debatable. The current study aims to elucidate the GBS subtypes of patients with an antecedent C. jejuni infection.
  
  
  METHODS
  Nerve conduction study results of 73 patients with GBS were reviewed. Patients were defined as having a recent C. jejuni infection when there was a positive stool culture or serological evidence of C. jejuni in the presence of preceding diarrhea.
  
  
  RESULTS
  A total of 23 patients had evidence of a recent C. jejuni infection. At the early stage, patients were classified as AMAN (n=9; 39%), AIDP (n=3; 13%) or equivocal (n=9) using existing electrophysiological criteria. Prolonged distal latencies and conduction slowing that were seen in 11 patients rapidly normalized within 3 weeks in seven, whereas four had minor abnormalities throughout the course. Subsequently, all patients showed either acute motor axonal neuropathy pattern or reversible conduction failure.
  
  
  CONCLUSIONS
  Serial neurophysiology suggests that C. jejuni infections are exclusive to axonal GBS.
  
  
  CONCLUSIONS
  Our findings suggest that AMAN can demonstrate the full complement of demyelinating features at the early stages of disease.
authors.affiliation: Department of Neurology, Dokkyo Medical University, Tochigi, Japan. kokubun@dokkyomed.ac.jp
authors.forename: Norito
authors.initials: N
authors.lastname: Kokubun
authors.forename: Nortina
authors.initials: N
authors.lastname: Shahrizaila
authors.forename: Michiaki
authors.initials: M
authors.lastname: Koga
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirata
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001369:Axons / Q000382:microbiology / Q000502:physiology; D002169:Campylobacter Infections / Q000150:complications*; D016123:Campylobacter jejuni; D005260:Female; D020275:Guillain-Barre Syndrome / Q000382:microbiology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
keywords: Acute inflammatory demyelinating polyneuropathy; Acute motor axonal neuropathy; Campylobacter jejuni; Guillain–Barré syndrome