title: Why the threshold criteria should not be modified for detection of possibly serious drug-induced hepatotoxicity in special groups of trial subjects.
authors.forename: John R
authors.initials: JR
authors.lastname: Senior
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D002986:Clinical Trials as Topic; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008495:Medical Oncology / Q000706:statistics & numerical data*; D015233:Models, Statistical
chemical_list: D000410:Alanine Transaminase; D001663:Bilirubin