title: Indian Ocean crossroads: human genetic origin and population structure in the Maldives.
abstract: The Maldives are an 850 km-long string of atolls located centrally in the northern Indian Ocean basin. Because of this geographic situation, the present-day Maldivian population has potential for uncovering genetic signatures of historic migration events in the region. We therefore studied autosomal DNA-, mitochondrial DNA-, and Y-chromosomal DNA markers in a representative sample of 141 unrelated Maldivians, with 119 from six major settlements. We found a total of 63 different mtDNA haplotypes that could be allocated to 29 mtDNA haplogroups, mostly within the M, R, and U clades. We found 66 different Y-STR haplotypes in 10 Y-chromosome haplogroups, predominantly H1, J2, L, R1a1a, and R2. Parental admixture analysis for mtDNA- and Y-haplogroup data indicates a strong genetic link between the Maldive Islands and mainland South Asia, and excludes significant gene flow from Southeast Asia. Paternal admixture from West Asia is detected, but cannot be distinguished from admixture from South Asia. Maternal admixture from West Asia is excluded. Within the Maldives, we find a subtle genetic substructure in all marker systems that is not directly related to geographic distance or linguistic dialect. We found reduced Y-STR diversity and reduced male-mediated gene flow between atolls, suggesting independent male founder effects for each atoll. Detected reduced female-mediated gene flow between atolls confirms a Maldives-specific history of matrilocality. In conclusion, our new genetic data agree with the commonly reported Maldivian ancestry in South Asia, but furthermore suggest multiple, independent immigration events and asymmetrical migration of females and males across the archipelago.
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, Postzone S5, 2300 RC Leiden, The Netherlands. knijff@lumc.nl
authors.forename: Jeroen
authors.initials: J
authors.lastname: Pijpe
authors.forename: Alex
authors.initials: A
authors.lastname: de Voogt
authors.forename: Mannis
authors.initials: M
authors.lastname: van Oven
authors.forename: Peter
authors.initials: P
authors.lastname: Henneman
authors.forename: Kristiaan J
authors.initials: KJ
authors.lastname: van der Gaag
authors.forename: Manfred
authors.initials: M
authors.lastname: Kayser
authors.forename: Peter
authors.initials: P
authors.lastname: de Knijff
mesh_terms: D044466:Asian People / Q000235:genetics*; D041322:Chromosomes, Human, Y; D004272:DNA, Mitochondrial / Q000235:genetics; D005260:Female; D051456:Gene Flow; D005819:Genetic Markers / Q000235:genetics; D005828:Genetics, Population; D006239:Haplotypes; D049690:History, Ancient; D063426:Human Migration / Q000266:history*; D006801:Humans; D007195:Indian Ocean Islands; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D004272:DNA, Mitochondrial; D005819:Genetic Markers