title: Antiproliferative activity of epi-cercosporin in human solid tumor cell lines.
abstract: From cultures of Cercospora piaropi, a phytopathogenic fungus isolated from symptomatic leaves of water hyacinth was obtained a red compound, which, according to the spectroscopic data, was epi-cercosporin. It showed in vitro antiproliferative activity against the panel of human solid tumor cells HBL-100, HeLa, SW1573 and WiDr. Cell cycle studies revealed that epi-cercosporin induces accumulation of cells in G2/M phase.
authors.affiliation: Laboratorio de Alta Tecnología de Xalapa, Universidad Veracruzana, Calle Médicos, 5, Col. Unidad del Bosque, 91010 Xalapa, Veracruz, México. atrigos@uv.mx
authors.forename: Angel
authors.initials: A
authors.lastname: Trigos
authors.forename: César
authors.initials: C
authors.lastname: Espinoza
authors.forename: Maricela
authors.initials: M
authors.lastname: Martínez
authors.forename: Olivia
authors.initials: O
authors.lastname: Márquez
authors.forename: Leticia G
authors.initials: LG
authors.lastname: León
authors.forename: José M
authors.initials: JM
authors.lastname: Padrón
authors.forename: Manuel
authors.initials: M
authors.lastname: Norted
authors.forename: José J
authors.initials: JJ
authors.lastname: Fernández
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D010569:Perylene / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; C580698:epi-cercosporin; D010569:Perylene; C026363:cercosporin