title: A composite neoplastic lesion of the vulva with mixed features of fibroadenoma and hidradenoma papilliferum combined with pseudoangiomatous stromal hyperplasia containing multinucleated giant cells.
abstract: Anogenital mammary-like glands (AGMLG) are nowadays considered a normal component of the anogenital area. Lesions affecting AGMLG are similar to those seen in breast. We present a case of a complex neoplastic lesion of the AGMLG with mixed features of fibroadenoma and hidradenoma papilliferum combined with pseudoangiomatous stromal hyperplasia. Multinucleated cells were detected in the pseudoangiomatous stromal hyperplasia areas as seen in some patients with neurofibromatosis type 1. The neoplasm is similar to rare mammary composite neoplasms that feature simultaneously patterns of a fibroepithelial neoplasms and intraductal papilloma.
authors.affiliation: *Department of Pathology, Clinical Oncological Scientific and Practical Centre for Specialized Medical Care, Saint Petersburg, Russia; †Department of Pathology Medical Faculty, Saint Petersburg State University, Russia; ‡Sikl's Department of Pathology, Faculty of Medicine in Pilsen, Charles University in Prague, Czech Republic; and §Department of Pathology, Medical Faculty, Bioptical Laboratory, Pilsen, Czech Republic.
authors.forename: Anastasia M
authors.initials: AM
authors.lastname: Konstantinova
authors.forename: Denisa
authors.initials: D
authors.lastname: Kacerovska
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kazakov
mesh_terms: D018250:Acrospiroma / Q000473:pathology*; D000798:Angiomatosis / Q000473:pathology*; D001941:Breast Diseases / Q000473:pathology*; D005260:Female; D018226:Fibroadenoma / Q000473:pathology*; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000473:pathology*; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology*