title: [Granulomatous invasive aspergillosis rhinosinusitis].
abstract: BACKGROUND
  Granulomatous invasive aspergillosis rhinosinusitis is a rare disease. Anatomopathologic and mycological examination allows the diagnosis. Treatment must be rapidly started in order to avoid orbital and intracranial complications.
  
  
  OBJECTIVE
  To analyze the main clinical, radiological, histopathological, mycological and therapeutic aspects of granulomatous invasive aspergillosis rhinosinusitis.
  
  
  METHODS
  This is a retrospective study included five patients operated for granulomatous invasive aspergillosis rhinosinusitis at the Otorhinolaryngology Head and Neck Department of La Rabta Hospital from 2000 to 2011.
  
  
  RESULTS
  These are four women and one man with mean age of 24.8 years. Functional symptoms were dominated by nasal obstruction and purulent rhinorrhea. Imaging showed a unilateral pansinusien filling extended to the nasal cavity with bone lysis. An orbital and endocranial extension was noted in two cases. Endonasal approach was performed in four patients and external approach in one patient. Anatomopathologic and mycological examination confirmed the diagnosis. All patients were started on antifungal therapy. One reccurence had been noted. Endonasal approach was performed.
  
  
  CONCLUSIONS
  Granulomatous invasive aspergillosis rhinosinusitis is a rare infection. The prognosis is particularly serious which warrants a rapid therapeutic care to avoid complications.
authors.affiliation: Service ORL et chirurgie maxillo-faciale, hôpital La Rabta, Jabbari, 1007 Tunis, Tunisie. rimzainine@yahoo.fr
authors.forename: R
authors.initials: R
authors.lastname: Zainine
authors.forename: M
authors.initials: M
authors.lastname: Ennaili
authors.forename: S
authors.initials: S
authors.lastname: Anane
authors.forename: Z
authors.initials: Z
authors.lastname: Khlifa
authors.forename: S
authors.initials: S
authors.lastname: Kedous
authors.forename: H
authors.initials: H
authors.lastname: Chahed
authors.forename: N
authors.initials: N
authors.lastname: Beltaief
authors.forename: G
authors.initials: G
authors.lastname: Besbes
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006099:Granuloma / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015508:Nasal Obstruction / Q000209:etiology; D009298:Nasal Polyps / Q000150:complications; D010014:Osteolysis / Q000209:etiology; D012189:Retrospective Studies; D012220:Rhinitis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000601:surgery; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014416:Tunisia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000935:Antifungal Agents