title: A case of IgG4-related hypophysitis without pituitary insufficiency.
abstract: BACKGROUND
  IgG4-related hypophysitis is a novel clinical disease entity, which is typically complicated by hypopituitarism.
  
  
  OBJECTIVE
  The objective of the study was to describe a novel case of IgG4-related hypophysitis without pituitary insufficiency and summarize the current relevant literature.
  
  
  METHODS
  A 55-year-old Japanese man presented with an enlarged pituitary gland and bitemporal hemianopsia. Endocrine studies revealed normal pituitary function, although his serum IgG4 level was high. The patient underwent a transsphenoidal biopsy of the pituitary gland, and the pathological tissues were consistent with IgG4-related hypophysitis. Oral prednisolone therapy was started, and after 6 months, his serum IgG4 level decreased and visual field improved.
  
  
  CONCLUSIONS
  We described the first case of IgG4-related hypophysitis without pituitary insufficiency. However, further case collection is needed to characterize the pathophysiology of IgG4-related hypophysitis.
authors.affiliation: Department of Neurosurgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. yujiro@nms.ac.jp
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hattori
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tahara
authors.forename: Yudo
authors.initials: Y
authors.lastname: Ishii
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kitamura
authors.forename: Chie
authors.initials: C
authors.lastname: Inomoto
authors.forename: Robert Yoshiyuki
authors.initials: RY
authors.lastname: Osamura
authors.forename: Akira
authors.initials: A
authors.lastname: Teramoto
authors.forename: Akio
authors.initials: A
authors.lastname: Morita
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006423:Hemianopsia / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009929:Organ Size / Q000187:drug effects; D010900:Pituitary Diseases / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D010902:Pituitary Gland / Q000187:drug effects / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D007074:Immunoglobulin G; D011239:Prednisolone