title: In vivo evaluation of lesion sterilization and tissue repair in primary teeth pulp therapy using two antibiotic drug combinations.
abstract: OBJECTIVE
  The purpose of this study is to evaluate and compare the clinical and radiographic effectiveness of Ciprofloxacin, Minocycline, Metronidazole combination with Ciprofloxacin, Minocycline and Tinidazole combination when used for Lesion Sterilization and Tissue Repair in primary teeth.
  
  
  METHODS
  25 healthy children, visiting Dept. of Pediatric & Preventive Dentistry, D.A.P.M.R.V. Dental College, Bangalore, India, aged between 6-9 years who were having 30 infected primary teeth are selected and divided into 2 groups. In Group A, a mixture of 3mix-MP Ciprofloxacin, Metronidazole and Minocycline was placed on the floor of the pulp chamber covering the root canal orifices. In Group B a mixture of Ciprofloxacin, Tinidazole and Minocycline was placed as a layer on the floor of the pulp chamber. The procedure was completed in a single visit. Post operative clinical evaluation was done after 1,6,12 and 24 months. Postoperative radiographic evaluation was done at 6, 12 and 24 months.
  
  
  RESULTS
  No statistically significant difference is observed between both the groups and a combination of Ciprofloxacin, Minocycline and Tinidazole antibacterial drugs can be used on teeth pulpally involved with physiologic root resorption.
  
  
  CONCLUSIONS
  After a 24 Month follow up, we can conclude that primary teeth with the periradicular lesions, can be conserved by using combination of Ciprofloxacin, Minocycline and Tinidazole antibacterial drugs.
authors.affiliation: Department of Pedodontics, Rajarajeshwari Dental College, Bangalore, India.
authors.forename: A R
authors.initials: AR
authors.lastname: Jaya
authors.forename: P
authors.initials: P
authors.lastname: Praveen
authors.forename: A
authors.initials: A
authors.lastname: Anantharaj
authors.forename: Karthik
authors.initials: K
authors.lastname: Venkataraghavan
authors.forename: Prathibha S
authors.initials: PS
authors.lastname: Rani
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002939:Ciprofloxacin / Q000627:therapeutic use; D003790:Dental Pulp Necrosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D008911:Minocycline / Q000627:therapeutic use; D010149:Postoperative Pain / Q000517:prevention & control; D010482:Periapical Abscess / Q000517:prevention & control; D011859:Radiography; D012038:Regeneration; D012388:Root Canal Irrigants / Q000627:therapeutic use*; D012391:Root Resorption; D014011:Tinidazole / Q000627:therapeutic use*; D014086:Tooth Mobility / Q000517:prevention & control; D014094:Tooth, Deciduous; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D012388:Root Canal Irrigants; D014011:Tinidazole; D008795:Metronidazole; D002939:Ciprofloxacin; D008911:Minocycline