title: Clinical characteristics and long-term outcome of patients with acute coronary syndromes and Takayasu arteritis.
abstract: BACKGROUND
  Monitoring of disease activity and the best therapeutic approach are a challenge in Takayasu arteritis (TA). When associated with acute coronary syndromes (ACS), the best interventional treatment has not been established. The objective of this study was to describe the baseline characteristics, clinical manifestations, treatment and long-term outcome of patients with TA and ACS.
  
  
  METHODS
  We retrospectively analyzed eight patients between 2004 and 2010. The following data were obtained: age, gender, clinical and electrocardiographic manifestations, Killip class, risk factors for ACS, markers of myocardial necrosis (CK-MB and troponin), creatinine clearance, left ventricular ejection fraction, inflammatory markers (C-reactive protein and erythrocyte sedimentation rate [ESR]), medication during hospital stay, angiographic findings, treatment (medical, percutaneous or surgical) and long-term outcome. Statistical data were expressed as percentages and absolute values.
  
  
  RESULTS
  All eight patients were women, median age 49 years. Typical chest pain was present in 37.5%. Elevated ESR was observed in 85.7%. Three patients underwent coronary artery bypass grafting, three underwent percutaneous coronary angioplasty (two with bare-metal stents and one with a drug-eluting stent) and two were treated medically. In-hospital mortality was 25%. There were no deaths during a mean follow-up of 30 months.
  
  
  CONCLUSIONS
  In our study, patients who were discharged home had good outcomes in long-term follow-up with medical, percutaneous or surgical treatment. ESR appears to be associated with ACS in TA.
authors.affiliation: Unidade Clínica de Emergência, Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. alexandre.soeiro@bol.com.br
authors.forename: Alexandre de Matos
authors.initials: Ade M
authors.lastname: Soeiro
authors.forename: Maria Carolina Feres de
authors.initials: MC
authors.lastname: Almeida
authors.forename: Tatiana Andreucci
authors.initials: TA
authors.lastname: Torres
authors.forename: Marcelo
authors.initials: M
authors.lastname: Franken
authors.forename: Felipe Gallego
authors.initials: FG
authors.lastname: Lima
authors.forename: Fernando
authors.initials: F
authors.lastname: Ganem
authors.forename: Roberto R
authors.initials: RR
authors.lastname: Giraldez
authors.forename: Luciano
authors.initials: L
authors.lastname: Baracioli
authors.forename: Múcio Oliveira
authors.initials: MO
authors.lastname: Tavares
authors.forename: Carlos V
authors.initials: CV
authors.lastname: Serrano
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Nicolau
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D013625:Takayasu Arteritis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome