title: The DHH1/RCKp54 family of helicases: an ancient family of proteins that promote translational silencing.
abstract: Translational control is a vital aspect of gene expression. Message specific translational repressors have been known for decades. Recent evidence, however, suggests that a general machinery exists that dampens the translational capacity of the majority of mRNAs. This activity has been best ascribed to a conserved family of RNA helicases called the DHH1/RCKp54 family. The function of these helicases is to promote translational silencing. By transitioning mRNA into quiescence, DHH1/RCKp54 helicases promote either mRNA destruction or storage. In this review we describe the known roles of these helicases and propose a mechanistic model to explain their mode of action. This article is part of a Special Issue entitled: The Biology of RNA helicases - Modulation for life.
authors.affiliation: Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Vlad
authors.initials: V
authors.lastname: Presnyak
authors.forename: Jeff
authors.initials: J
authors.lastname: Coller
mesh_terms: D000818:Animals; D053487:DEAD-box RNA Helicases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D034622:RNA Interference; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D053487:DEAD-box RNA Helicases