title: Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin: relationships with metabolic outcomes.
abstract: OBJECTIVE
  The effects of fructose and glucose consumption on plasma acylation stimulating protein (ASP), adiponectin, and leptin concentrations relative to energy intake, body weight, adiposity, circulating triglycerides, and insulin sensitivity were determined.
  
  
  METHODS
  Thirty two overweight/obese adults consumed glucose- or fructose-sweetened beverages (25% energy requirement) with their ad libitum diets for 8 weeks, followed by sweetened beverage consumption for 2 weeks with a standardized, energy-balanced diet. Plasma variables were measured at baseline, 2, 8, and 10 weeks, and body adiposity and insulin sensitivity at baseline and 10 weeks.
  
  
  RESULTS
  Fasting and postprandial ASP concentrations increased at 2 and/or 8 weeks. ASP increases correlated with changes in late-evening triglyceride concentrations. At 10 weeks, fasting adiponectin levels decreased in both groups, and decreases were inversely associated with baseline intra-abdominal fat volume. Sugar consumption increased fasting leptin concentrations; increases were associated with body weight changes. The 24-h leptin profiles increased during glucose consumption and decreased during fructose consumption. These changes correlated with changes of 24-h insulin levels.
  
  
  CONCLUSIONS
  The consumption of fructose and glucose beverages induced changes in plasma concentrations of ASP, adiponectin, and leptin. Further study is required to determine if these changes contribute to the metabolic dysfunction observed during fructose consumption.
authors.affiliation: Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Quebec, Canada.
authors.forename: Reza
authors.initials: R
authors.lastname: Rezvani
authors.forename: Katherine
authors.initials: K
authors.lastname: Cianflone
authors.forename: John P
authors.initials: JP
authors.lastname: McGahan
authors.forename: Lars
authors.initials: L
authors.lastname: Berglund
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Bremer
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Keim
authors.forename: Steven C
authors.initials: SC
authors.lastname: Griffen
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Havel
authors.forename: Kimber L
authors.initials: KL
authors.lastname: Stanhope
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050154:Adiposity; D000328:Adult; D000368:Aged; D001628:Beverages; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003176:Complement C3; D004032:Diet; D002149:Energy Intake; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D050152:Intra-Abdominal Fat / Q000378:metabolism; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D064427:Nutritive Sweeteners / Q000008:administration & dosage / Q000009:adverse effects*; D009765:Obesity / Q000097:blood; D017698:Postmenopause; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; C038245:C3 protein, human; D003176:Complement C3; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D064427:Nutritive Sweeteners; D014280:Triglycerides; D005632:Fructose