title: Progressive presynaptic dopaminergic deterioration in Huntington disease: a [123I]-FP-CIT SPECT two-year follow-up study.
abstract: To illustrate the potential of [I]-FP-CIT SPECT DaTSCAN® in investigating the progression of presynaptic dopaminergic degeneration in Huntington disease (HD), we performed a 2-year follow-up [I]-FP-CIT study on 4 HD patients, evaluating the SPECT imaging based on qualitative and semiquantitative analysis. The mean annual decline in [I]-FP-CIT uptake in caudate and putamen after 2 years of follow-up was 5.8% and 9.6%, respectively. Our findings suggest that [I]-FP-CIT SPECT is useful in investigating the progression of presynaptic dopaminergic degeneration in HD, and may be useful as a disease biomarker, providing an objective method for measuring the effectiveness of future neuroprotective therapies.
authors.affiliation: From the *Neurology Department, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), and †Servei de Medicina Nuclear, Hospital Universitari Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain; and ‡Department of Statistics, University of Barcelona, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Gamez
authors.forename: Carles
authors.initials: C
authors.lastname: Lorenzo-Bosquet
authors.forename: Gemma
authors.initials: G
authors.lastname: Cuberas-Borrós
authors.forename: Francesc
authors.initials: F
authors.lastname: Carmona
authors.forename: Mercedes
authors.initials: M
authors.lastname: Badía
authors.forename: Joaquin
authors.initials: J
authors.lastname: Castilló
authors.forename: Mercedes
authors.initials: M
authors.lastname: Badía
authors.forename: Oriol
authors.initials: O
authors.lastname: de Fabregues
authors.forename: Jorge
authors.initials: J
authors.lastname: Hernández-Vara
authors.forename: Joan
authors.initials: J
authors.lastname: Castell-Conesa
mesh_terms: D059290:Dopaminergic Neurons / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013569:Synapses / Q000473:pathology*; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
chemical_list: D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane