title: Bioinspired antimicrobial and biocompatible bacterial cellulose membranes obtained by surface functionalization with aminoalkyl groups.
abstract: There has been a great deal of interest in the use of nanostructured bacterial cellulose membranes for biomedical applications, including tissue implants, wound healing, and drug delivery. However, as bacterial cellulose does not intrinsically present antimicrobial properties, in the present study, antimicrobial bacterial cellulose membranes were obtained by chemical grafting of aminoalkyl groups onto the surface of its nanofibrillar network. This approach intends to mimic intrinsic antimicrobial properties of chitosan. Interestingly, these novel grafted bacterial cellulose membranes (BC-NH2) are simultaneously lethal against S. aureus and E. coli and nontoxic to human adipose-derived mesenchymal stem cells (ADSCs) and thus may be useful for biomedical applications. In addition to these biological properties, the bioactive nanostructured BC-NH2 membranes also present improved mechanical and thermal properties.
authors.affiliation: Department of Chemistry and CICECO, University of Aveiro, 3810-193 Aveiro, Portugal. susana.fernandes@ehu.es
authors.forename: Susana C M
authors.initials: SC
authors.lastname: Fernandes
authors.forename: Patrizia
authors.initials: P
authors.lastname: Sadocco
authors.forename: Ana
authors.initials: A
authors.lastname: Alonso-Varona
authors.forename: Teodoro
authors.initials: T
authors.lastname: Palomares
authors.forename: Arantxa
authors.initials: A
authors.lastname: Eceiza
authors.forename: Armando J D
authors.initials: AJ
authors.lastname: Silvestre
authors.forename: Iñaki
authors.initials: I
authors.lastname: Mondragon
authors.forename: Carmen S R
authors.initials: CS
authors.lastname: Freire
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000737:chemistry* / Q000378:metabolism; D001704:Biopolymers / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002448:Cell Adhesion; D049109:Cell Proliferation; D002482:Cellulose / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D008567:Membranes, Artificial; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects*; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001704:Biopolymers; D008567:Membranes, Artificial; D002482:Cellulose