title: A case of acute myelogenous leukaemia characterised by the BCR-FGFR1 translocation.
abstract: The 8p11 myeloproliferative syndrome is a rare atypical disorder defined by the presence of rearrangements between the fibroblast growth factor receptor 1 (FGFR1) and 1 of 13 partner genes described to date, including the BCR gene on chromosome 22. The disease characterised by the BCR-FGFR1 fusion gene has distinct biological and clinical features, with significant diversity among the published cases. We report a case of BCR-FGFR1 disease which was presented as acute myeloid leukaemia with an aggressive clinical course and we review all the adult cases published in the literature.
authors.affiliation: Hematology and Lymphoma Department, 'Evangelismos' Athens General Hospital, Athens, Greece. almatikas@gmail.com
authors.forename: Alexios
authors.initials: A
authors.lastname: Matikas
authors.forename: Ifigeneia
authors.initials: I
authors.lastname: Tzannou
authors.forename: Dimitra
authors.initials: D
authors.lastname: Oikonomopoulou
authors.forename: Maria
authors.initials: M
authors.lastname: Bakiri
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D051562:Proto-Oncogene Proteins c-bcr / Q000235:genetics*; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D051496:Receptor, Fibroblast Growth Factor, Type 1; D051562:Proto-Oncogene Proteins c-bcr