title: Physiological temperature has a crucial role in amyloid β in the absence and presence of hydrophobic and hydrophilic nanoparticles.
abstract: Amyloid beta fibrillation can lead to major disorder of neurons processes and is associated with several neuronal diseases (e.g., Alzheimer's disease). We report here an importance of slight temperature changes, in the physiological range (35-42 °C), on the amyloid fibrillation process in the presence and absence of hydrophilic (silica) and hydrophobic (polystyrene) nanoparticles (NPs). The results highlight the fact that slight increases in temperature can induce inhibitory and acceleratory effects of hydrophobic and hydrophilic NPs on the fibrillation process, respectively. Using further in vivo considerations, the outcomes of this study can be used for considerable modifications on the current diagnosis and treatment approaches in amyloid-involved diseases.
authors.affiliation: National Cell Bank, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Ghavami
authors.forename: Meisam
authors.initials: M
authors.lastname: Rezaei
authors.forename: Reza
authors.initials: R
authors.lastname: Ejtehadi
authors.forename: Mina
authors.initials: M
authors.lastname: Lotfi
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Shokrgozar
authors.forename: Baharak
authors.initials: B
authors.lastname: Abd Emamy
authors.forename: Jens
authors.initials: J
authors.lastname: Raush
authors.forename: Morteza
authors.initials: M
authors.lastname: Mahmoudi
mesh_terms: D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology*; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity*; D010829:Physiological Phenomena / Q000502:physiology*; D011137:Polystyrenes / Q000737:chemistry / Q000633:toxicity; D012822:Silicon Dioxide / Q000737:chemistry / Q000633:toxicity; D013696:Temperature
chemical_list: D016229:Amyloid beta-Peptides; D011137:Polystyrenes; D012822:Silicon Dioxide