title: Susac syndrome and multifocal motor neuropathy first manifesting in pregnancy.
abstract: Susac Syndrome (SS) and multifocal motor neuropathy (MMN) are rare autoimmune neurological conditions which can affect women of childbearing years. The effect of pregnancy on these disorders is poorly characterised. We report a case of SS first manifesting in pregnancy with challenges in diagnosis and management and a poor clinical outcome, and a case of MMN manifesting in pregnancy then relapsing in a subsequent pregnancy. A summary of other cases in the literature and the postulated underlying immune mechanisms is presented.
authors.affiliation: Royal Brisbane and Women's Hospital-Neurology, Butterfield Street, Herston, Brisbane, QLD 4029, Australia. z.ioannides@gmail.com
authors.forename: Zara A
authors.initials: ZA
authors.lastname: Ioannides
authors.forename: Caroline
authors.initials: C
authors.lastname: Airey
authors.forename: Narelle
authors.initials: N
authors.lastname: Fagermo
authors.forename: Stefan
authors.initials: S
authors.lastname: Blum
authors.forename: Pamela A
authors.initials: PA
authors.lastname: McCombe
authors.forename: Robert D
authors.initials: RD
authors.lastname: Henderson
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Henderson
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000175:diagnosis*; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D004401:Dysarthria; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D018908:Muscle Weakness; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000188:drug therapy; D055955:Susac Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
chemical_list: D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D008727:Methotrexate