title: Whole-brain functional connectivity increases with extended duration of focal epileptiform activity.
abstract: The analysis of interictal epileptiform discharges (IEDs) using magnetoencephalography (MEG) is utilized for the localization of seizure onset zones in the presurgical planning of epilepsy patients. Additionally, resting-state functional connectivity analyses using the IED area may provide novel insight into the underlying brain networks. In this study, we evaluate whether chronicity of seizures is related to whole-brain functional connectivity metrics using the area of IED generation (derived from MEG) as the seed region. We found a positive correlation between the duration of seizures and beta-band functional connectivity between the epileptogenic zone and other brain areas. This suggests the presence of inhibitory GABAergic modulation of distal brain regions in response to chronic epileptiform activity.
authors.affiliation: Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198-2045, USA. deepak.madhavan@unmc.edu
authors.forename: Deepak
authors.initials: D
authors.lastname: Madhavan
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Heinrichs-Graham
authors.forename: Tony W
authors.initials: TW
authors.lastname: Wilson
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002908:Chronic Disease; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male