title: [Involvement of some subtypes of 5-HT2-receptors in affective behavior in female rats].
abstract: The present work was devoted to the comparative analysis of influence of chronic administration of 5-HT(2B/2C) receptors agonist - m-CPP (0,5 mg/kg, i.p.) and 5-HT(2A/2C) receptors antagonist - ketanserine (0,1 mg/kg, i.p.) for 14 days on the anxiety and depressive-like behavior in adult female rats. It was established that chronic ketanserine administration rendered antidepressive and anxiolytic effects in females during estrous and proestrous. M-CPP administration also resulted in antidepressive effect in estrous and proestrous. Also, it was noted definite modulation of anxiety behavior in connection of ovary cycle phases in rats treated with m-CPP: at increased level of estrogens was anxiolytic effect while at reduced level of estrogen - anxiogenic effect. It is suggested the involvement of different subtypes of 5-HT receptors in the mechanisms of anxiety-depressive-like behavior at alterations of hormonal balance during ovary cycle. The data obtained indicate a close interaction between the ovary hormonal and serotonergic systems of the brain in the mechanisms of anxiety and depression.
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Fedotova
authors.forename: N E
authors.initials: NE
authors.lastname: Ordian
authors.forename: H O
authors.initials: HO
authors.lastname: Frolova
authors.forename: V I
authors.initials: VI
authors.lastname: Soboliev
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001007:Anxiety / Q000503:physiopathology / Q000517:prevention & control*; D003863:Depression / Q000503:physiopathology / Q000517:prevention & control*; D004967:Estrogens / Q000378:metabolism; D004971:Estrus / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007274:Injections, Intraperitoneal; D007650:Ketanserin / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011359:Proestrus / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D044403:Receptor, Serotonin, 5-HT2B / Q000378:metabolism*; D044405:Receptor, Serotonin, 5-HT2C / Q000378:metabolism*; D058826:Serotonin 5-HT2 Receptor Agonists / Q000494:pharmacology; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D004967:Estrogens; D010879:Piperazines; D044402:Receptor, Serotonin, 5-HT2A; D044403:Receptor, Serotonin, 5-HT2B; D044405:Receptor, Serotonin, 5-HT2C; D058826:Serotonin 5-HT2 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D007650:Ketanserin; C015068:1-(3-chlorophenyl)piperazine