title: A general synthesis of bis-indolylpiperazine-2,5-diones.
abstract: The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5'-methoxy-3'-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7'-methyl-3'-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6'-chloro-3'-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by 1H-NMR.
authors.affiliation: Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA. cwhitlock@georgiasouthern.edu
authors.forename: Stephen
authors.initials: S
authors.lastname: Crooke
authors.forename: Christine
authors.initials: C
authors.lastname: Whitlock
mesh_terms: D054659:Diketopiperazines / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D010879:Piperazines / Q000138:chemical synthesis*
chemical_list: D054659:Diketopiperazines; D007211:Indoles; D010879:Piperazines; C522350:1,4-dimethylpiperazine