title: Computational modeling with fluid-structure interaction of the severe m1 stenosis before and after stenting.
abstract: OBJECTIVE
  Image-based computational models with fluid-structure interaction (FSI) can be used to perform plaque mechanical analysis in intracranial artery stenosis. We described a process in FSI study applied to symptomatic severe intracranial (M1) stenosis before and after stenting.
  
  
  METHODS
  Reconstructed 3D angiography in STL format was transferred to Magics for smoothing of vessel surface and trimming of branch vessels and to HyperMesh for generating tetra volume mesh from triangular surface-meshed 3D angiogram. Computational analysis of blood flow in the blood vessels was performed using the commercial finite element software ADINA Ver 8.5. The distribution of wall shear stress (WSS), peak velocity and pressure was analyzed before and after intracranial stenting.
  
  
  RESULTS
  The wall shear stress distributions from Computational fluid dynamics (CFD) simulation with rigid wall assumption as well as FSI simulation before and after stenting could be compared. The difference of WSS between rigid wall and compliant wall model both in pre- and post-stent case is only minor except at the stenosis region. These WSS values were greatly reduced after stenting to 15~20 Pa at systole and 3~5 Pa at end-diastole in CFD simulation, which are similar in FSI simulations.
  
  
  CONCLUSIONS
  Our study revealed that FSI simulation before and after intracranial stenting was feasible despite of limited vessel wall dimension and could reveal change of WSS as well as flow velocity and wall pressure.
authors.affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Soonchan
authors.initials: S
authors.lastname: Park
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Lee
authors.forename: Ok Kyun
authors.initials: OK
authors.lastname: Lim
authors.forename: Inki
authors.initials: I
authors.lastname: Min
authors.forename: Minhtuan
authors.initials: M
authors.lastname: Nguyen
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Ko
authors.forename: Kyunghwan
authors.initials: K
authors.lastname: Yoon
authors.forename: Dae Chul
authors.initials: DC
authors.lastname: Suh
keywords: Atherosclerosis; Cerebral artery; Computational modeling; Fluid structure interaction; Stenting