title: Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam.
abstract: OBJECTIVE
  To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis).
  
  
  METHODS
  The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells.
  
  
  RESULTS
  It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage).
  
  
  CONCLUSIONS
  Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor.
authors.affiliation: Department of Especialized Health, UEPA, Para, Brazil. narambotelho@gmail.com
authors.forename: Nara Macedo
authors.initials: NM
authors.lastname: Botelho
authors.forename: Suelen Costa
authors.initials: SC
authors.lastname: Corrêa
authors.forename: Rodolfo Costa
authors.initials: RC
authors.lastname: Lobato
authors.forename: Renan Kleber Costa
authors.initials: RK
authors.lastname: Teixeira
authors.forename: Juarez Antônio Simões
authors.initials: JA
authors.lastname: Quaresma
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001453:Balsams / Q000627:therapeutic use*; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D002584:Cervix Uteri / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D005260:Female; D007150:Immunohistochemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001453:Balsams; C114971:copaiba balsam