title: State of the art for cardiotoxicity due to chemotherapy and to targeted therapies: a literature review.
abstract: Cardiotoxicity is a common complication of many anti-cancer agents and it remains a major limitation, strongly impacting the quality of life and the overall survival, regardless of the oncologic prognosis. Cardiotoxicity may occur during or shortly after treatment (within days or weeks), or it may become evident months, and sometimes years, after completion of chemotherapy. Cardiotoxicity associated with cancer therapies can range from asymptomatic subclinical abnormalities, including electrocardiographic changes and temporary left ventricular ejection fraction decline, to life-threatening events such as congestive heart failure or acute coronary syndromes. The aim of this review is to summarize potential cancer chemotherapeutics-related cardiovascular toxicities in adult cancer-patients and to suggest monitoring and treatment options for each agent, that can serve as a tool in the clinical practice.
authors.affiliation: Medical Oncology, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I - GM Lancisi - G Salesi, Ancona, Italy. Electronic address: r.berardi@univpm.it.
authors.forename: Rossana
authors.initials: R
authors.lastname: Berardi
authors.forename: Miriam
authors.initials: M
authors.lastname: Caramanti
authors.forename: Agnese
authors.initials: A
authors.lastname: Savini
authors.forename: Silvia
authors.initials: S
authors.lastname: Chiorrini
authors.forename: Chiara
authors.initials: C
authors.lastname: Pierantoni
authors.forename: Azzurra
authors.initials: A
authors.lastname: Onofri
authors.forename: Zelmira
authors.initials: Z
authors.lastname: Ballatore
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: De Lisa
authors.forename: Paola
authors.initials: P
authors.lastname: Mazzanti
authors.forename: Stefano
authors.initials: S
authors.lastname: Cascinu
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents
keywords: Anticancer therapy; Cardiotoxicity; Cardiovascular toxicity; Chemotherapy; Targeted therapies