title: Association of PvuII polymorphism in ESR1 gene with impaired ovarian reserve in patients from Ukraine.
abstract: The association of ESR1 PvuII polymorphism (rs2334693) with impaired ovarian reserve was studied by genotyping this polymorphism using PCR-RFLP in patients and two control groups from Ukraine. Statistically significant differences in the prevalence of p-allele frequency (-397T) was seen in the group of patients with impaired ovarian reserve (0.597) compared to control groups I under 35years (0.480) and II over 35years (0.453), both p<0.05. The data suggest that PvuII polymorphism of ESR1 is associated with diminished ovarian reserve.
authors.affiliation: Department of Human Genomics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kiev, Ukraine.
authors.forename: Ganna
authors.initials: G
authors.lastname: Livshyts
authors.forename: Svetlana
authors.initials: S
authors.lastname: Podlesnaja
authors.forename: Sergey
authors.initials: S
authors.lastname: Kravchenko
authors.forename: Ludmila
authors.initials: L
authors.lastname: Livshits
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D006801:Humans; D009866:Oogenesis; D011110:Polymorphism, Genetic; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D014455:Ukraine
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha