title: [Whole-genome sequencing: a new approach for understanding of pathogenesis and individualized treatment of cancer].
abstract: With the development of sequencing technology, the cost of whole-genome sequencing was significantly declined.Meanwhile, with the application of combined whole-genome sequencing with epigenetic analysis on methylation and histone acetylation, the comprehensive and systematic analysis of numerous samples became a reality and we are able to re-understand the genesis and development of cancer. New ideas are emerging in comparative genomics research methods, from comparison of genomes among different individuals to horizontal self-comparison of different tissues and vertical self-comparison of genomes recently.Individualized diagnosis and treatment of cancer has shown a bright future.
authors.affiliation: Taizhou Hospital Affiliated of Wenzhou Medical College, Linhai, China.
authors.forename: Yingqiu
authors.initials: Y
authors.lastname: Pan
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Shuqing
authors.initials: S
authors.lastname: Chen
mesh_terms: D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D057285:Precision Medicine; D017422:Sequence Analysis, DNA / Q000379:methods*