title: Phylogenetic analysis of six-domain multi-copper blue proteins.
abstract: Multicopper blue proteins, composed of several repetitive copper-binding domains similar to one-domain cupredoxin-like proteins, were found in almost all organisms. They are classified into the three different groups, based on their two-, three- or six-domain organization. We found orthologs of chordate six-domain copper-binding proteins in animals, plants, bacteria and archea. The phylogenetic analysis of 183 multicopper blue proteins and their copper-binding sites comparison make us think that all the modern six-domain blue proteins have originated from the common ancestral six-domain protein in the process of gene duplication and copper-binding sites loss as a result of amino acid substitutions.
authors.affiliation: Reseach Institute of Influenza.
authors.forename: Andrey
authors.initials: A
authors.lastname: Vasin
authors.forename: Sergey
authors.initials: S
authors.lastname: Klotchenko
authors.forename: Ludmila
authors.initials: L
authors.lastname: Puchkova