title: Gender differences in cholinergic and dopaminergic deficits in Parkinson disease.
abstract: As Parkinson disease (PD) may affect men and women differentially, we investigated gender differences in regional projection system integrity in 148 PD subjects (36 women, 112 men) using monoaminergic [11C]dihydrotetrabenazine and acetylcholinesterase [11C]PMP positron emission tomography. After controlling for age, disease duration, and Hoehn and Yahr score, men showed 5.9% greater caudate dopaminergic denervation (p = 0.0018) and 5.8% greater neocortical cholinergic denervation (p = 0.0097). No significant gender differences were seen in putaminal dopaminergic or thalamic cholinergic denervation.
authors.affiliation: Department of Neurology, University of Michigan, 2301 Commonwealth Blvd, Suite 1013, Ann Arbor, MI, 48105, USA, vikaskot@med.umich.edu.
authors.forename: Vikas
authors.initials: V
authors.lastname: Kotagal
authors.forename: Roger L
authors.initials: RL
authors.lastname: Albin
authors.forename: Martijn L T M
authors.initials: ML
authors.lastname: Müller
authors.forename: Robert A
authors.initials: RA
authors.lastname: Koeppe
authors.forename: Kirk A
authors.initials: KA
authors.lastname: Frey
authors.forename: Nicolaas I
authors.initials: NI
authors.lastname: Bohnen
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D059329:Cholinergic Neurons / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D059290:Dopaminergic Neurons / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D012727:Sex Characteristics