title: Changes in self-regulation-related prefrontal activities in eating disorders: a near infrared spectroscopy study.
abstract: OBJECTIVE
  The aim of this study is to clarify the symptomatology of the eating disorders examining the prefrontal function and activity associated with self-regulation among participants with or without eating disorders.
  
  
  METHODS
  Ten patients with anorexia nervosa, fourteen with bulimia nervosa, and fourteen healthy control participants performed two cognitive tasks assessing self-regulatory functions, an auditorily distracted word fluency task and a rock-paper-scissors task under the measurements on prefrontal oxyhemoglobin concentration with near infrared spectroscopy. The psychiatric symptoms of patient groups were assessed with several questionnaires.
  
  
  RESULTS
  Patients with bulimia nervosa showed decreased performances and prefrontal hyper activation patterns. Prefrontal activities showed a moderate negative correlation with task performances not in the patient groups but only in the healthy participants. The prefrontal activities of the patient groups showed positive correlations with some symptom scale aspects.
  
  
  CONCLUSIONS
  The decreased cognitive abilities and characteristic prefrontal activation patterns associated with self-regulatory functions were shown in patients with bulimia nervosa, which correlated with their symptoms. These findings suggest inefficient prefrontal self-regulatory function of bulimia nervosa that associate with its symptoms.
authors.affiliation: Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University Chiba Chuo, Chiba, Japan. csutoh@graduate.chiba-u.jp
authors.forename: Chihiro
authors.initials: C
authors.lastname: Sutoh
authors.forename: Michiko
authors.initials: M
authors.lastname: Nakazato
authors.forename: Daisuke
authors.initials: D
authors.lastname: Matsuzawa
authors.forename: Kadushi
authors.initials: K
authors.lastname: Tsuru
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Niitsu
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
mesh_terms: D003071:Cognition / Q000502:physiology*; D001068:Feeding and Eating Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007564:Japan; D010108:Oxyhemoglobins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D012927:Social Control, Informal; D013055:Spectrophotometry, Infrared; D011795:Surveys and Questionnaires
chemical_list: D010108:Oxyhemoglobins