title: MicroRNA and Epigenetics: Diagnostic and Therapeutic Opportunities.
abstract: MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that control cellular and developmental processes by targeting messenger RNAs (mRNA). These small non-coding RNAs (ncRNAs) are aberrantly expressed in cancer, and are known to contribute to tumorigenesis and disease progression. Therapeutic strategies based on modulating miRNAs activity are emerging due to the ability of these ncRNAs to influence cellular behavior. MiRNA levels predict disease prognosis and overall patient survival, and reconstituting their basal levels has been proven to inhibit tumor growth and metastasis. Different delivery mechanisms have been testedin vivo, however many challenges need to be overcome before their utilization in the clinic. Moreover, it has been found that circulating miRNAs in body fluids have the potential to reshape cancer diagnosis and prognosis by functioning as biomarkers and indicators of progression and metastasis. These miRNAs as biofluids-based biomarkers provide an alternative strategy for early diagnosis and treatment of cancer patients.
authors.affiliation: Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston TX 77030, USA.
authors.forename: Paloma Del C
authors.initials: PD
authors.lastname: Monroig
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
keywords: Biomarkers; Cancer; Diagnosis; Epigenetics; Pathobiology; Therapy; microRNA