title: Embroidered and surface coated polycaprolactone-co-lactide scaffolds: a potential graft for bone tissue engineering.
abstract: Tissue engineering and regenerative techniques targeting bone include a broad range of strategies and approaches to repair, augment, replace or regenerate bone tissue. Investigations that are aimed at optimization of these strategies until clinical translation require control of systemic factors as well as modification of a broad range of key parameters. This article reviews a possible strategy using a tissue engineering approach and systematically describes a series of experiments evaluating the properties of an embroidered and surface coated polycaprolactone-co-lactide scaffold being considered as bone graft substitute for large bone defects. The scaffold design and fabrication, the scaffolds properties, as well as its surface modification and their influence in vitro are evaluated, followed by in vivo analysis of the scaffolds using orthotopic implantation models in small and large animals.
authors.affiliation: Catgut GmbH, Markneukirchen, Germany.
authors.forename: Barbe
authors.initials: B
authors.lastname: Rentsch
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bernhardt
authors.forename: Dieter
authors.initials: D
authors.lastname: Scharnweber
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schneiders
authors.forename: Stefan
authors.initials: S
authors.lastname: Rammelt
authors.forename: Claudia
authors.initials: C
authors.lastname: Rentsch
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes; D001842:Bone and Bones / Q000737:chemistry*; D002448:Cell Adhesion; D006801:Humans; D008422:Materials Testing; D010012:Osteogenesis; D011091:Polyesters / Q000737:chemistry*; D019736:Prostheses and Implants; D011474:Prosthesis Design; D051381:Rats; D012756:Sheep; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; C553659:polycaprolactone-co-lactide
keywords: bone substitute; chondroitin sulfate; collagen type I; critical size defect; nude rat; polycaprolactone-co-lactide; scaffold; sheep; tissue engineering