title: Primary lung cancer complicated by malignant lymphoma in two cases of epstein-barr virus infection.
abstract: BACKGROUND
  Double cancer is defined as the co-existence of two pathologically distinct cancers. Double cancer consisting of a lung adenocarcinoma and a malignant lymphoma has seldom been reported in time synchronous cases or prior to cases of primary lung cancer, except in those after treatment for malignant lymphoma.
  
  
  METHODS
  Case 1 was a 71-year-old woman who was treated at our hospital for chronic hepatitis C, nontuberculous mycobacteria infection, and bronchiectasis. She was diagnosed with a stage IV lung adenocarcinoma (cT1bN2M1b) with a synchronous complicating diffuse large B-cell-type lymphoma. Case 2 was a 62-year-old man who had undergone resection of a stage IB lung adenocarcinoma (pT2aN0M0). Thirty months after the surgery, a diffuse large B-cell-type lymphoma was discovered. In both cases, high antiviral capsid antigen IgG antibody titers were observed.
  
  
  CONCLUSIONS
  Epstein-Barr virus may be associated with the incidence of multiple cancers given the pathological evidence from our two double cancer cases.
authors.affiliation: Department of Internal Medicine and, Chuno Kosei Hospital, Seki, Japan.
authors.forename: Zentaro
authors.initials: Z
authors.lastname: Ohno
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Tamaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohsuga
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iwata
authors.forename: Norio
authors.initials: N
authors.lastname: Yasuda
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Mori
keywords: Diffuse large B-cell-type lymphoma; Double cancer; Epstein-Barr virus infection; Lung adenocarcinoma