title: Platelet counts and liver enzymes after bariatric surgery.
abstract: BACKGROUND
  Obesity is characterized by liver steatosis, chronic inflammation, and increased liver enzymes, that is, gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for nonalcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are associated with inflammatory conditions and are a valuable biomarker of the degree of fibrosis in NAFLD. We investigated alterations in PC, GGT, and ALT after biliopancreatic diversion with duodenal switch (BPD-DS) and Roux-en-Y gastric bypass (RYGBP).
  
  
  METHODS
  Ten morbidly obese patients (body mass index, BMI: 53.5 ± 3.8 kg/m(2)) who underwent BPD-DS were evaluated preoperatively (baseline) and 1 year (1st followup) and 3 years (2nd followup) after surgery and compared with 21 morbidly obese patients (BMI: 42.3 ± 5.2 kg/m(2)) who underwent RYGBP.
  
  
  RESULTS
  Over the 3 years of followup, changes in BPD-DS and RYGBP patients (BPD-DS/RYGBP) were as follows: BMI (-44%/-24%), GGT (-63%/-52%), and ALT (-48%/-62%). PC decreased (-21%) statistically significantly only in BPD-DS patients.
  
  
  CONCLUSIONS
  Morbidly obese patients treated by RYGBP or BPD-DS show sustained reductions in BMI, ALT, and GGT. The decrease in PC and liver enzymes after BPD-DS may reflect a more pronounced decrease of liver-fat-content-related inflammation and, as a result, a lowered secondary thrombocytosis.
authors.affiliation: Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden.
authors.forename: Hans-Erik
authors.initials: HE
authors.lastname: Johansson
authors.forename: Arvo
authors.initials: A
authors.lastname: Haenni
authors.forename: Björn
authors.initials: B
authors.lastname: Zethelius
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D050110:Bariatric Surgery; D015904:Biliopancreatic Diversion; D015992:Body Mass Index; D005234:Fatty Liver / Q000209:etiology / Q000628:therapy; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000628:therapy; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D009767:Obesity, Morbid / Q000097:blood / Q000150:complications / Q000601:surgery*; D010976:Platelet Count; D015431:Weight Loss; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase