title: Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia.
abstract: Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant for psychiatric disorders.
authors.affiliation: Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USA.
authors.forename: Rachael J
authors.initials: RJ
authors.lastname: Bloom
authors.forename: Anna K
authors.initials: AK
authors.lastname: Kähler
authors.forename: Ann L
authors.initials: AL
authors.lastname: Collins
authors.forename: Guanhua
authors.initials: G
authors.lastname: Chen
authors.forename: Tyrone D
authors.initials: TD
authors.lastname: Cannon
authors.forename: Christina
authors.initials: C
authors.lastname: Hultman
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Sullivan
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D055028:Comparative Genomic Hybridization; D056915:DNA Copy Number Variations / Q000235:genetics*; D004200:Diseases in Twins / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D012559:Schizophrenia / Q000235:genetics*; D013548:Sweden; D014430:Twins, Monozygotic; D014481:United States