title: Role of oxidative stress in infectious diseases. A review.
abstract: Oxidative stress plays a dual role in infections. Free radicals protect against invading microorganisms, and they can also cause tissue damage during the resulting inflammation. In the process of infection, there is generation of reactive species by myeloperoxidase, NADPH oxidase, and nitric oxide synthase. On the other hand, reactive species can be generated among others, by cytochrome P450, some metals, and xanthine oxidase. Some pathologies arising during infection can be attributed to oxidative stress and generation of reactive species in infection can even have fatal consequences. This article reviews the basic pathways in which reactive species can accumulate during infectious diseases and discusses the related health consequences.
authors.affiliation: Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 50001, Hradec Kralove, Czech Republic, miroslav.pohanka@gmail.com.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Pohanka
mesh_terms: D003141:Communicable Diseases / Q000276:immunology* / Q000503:physiopathology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005609:Free Radicals / Q000276:immunology* / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D053858:Metabolic Networks and Pathways; D008670:Metals / Q000378:metabolism; D019255:NADPH Oxidases / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress; D009195:Peroxidase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D005609:Free Radicals; D008670:Metals; D003577:Cytochrome P-450 Enzyme System; D009195:Peroxidase; D019001:Nitric Oxide Synthase; D014969:Xanthine Oxidase; D019255:NADPH Oxidases