title: CD4 and CD8 T cells directly recognize murine gammaherpesvirus 68-immortalized cells and prevent tumor outgrowth.
abstract: There has been extensive research regarding T cell recognition of Epstein-Barr virus-transformed cells; however, less is known regarding the recognition of B cells immortalized by gamma-2 herpesviruses. Here we show that B cells immortalized by murine gammaherpesvirus 68 (MHV-68, γHV-68) can be controlled by either CD4 or CD8 T cells in vivo. We present evidence for the direct recognition of infected B cells by CD4 and CD8 T cells. These data will help in the development of immunotherapeutic approaches combating gamma-2 herpesvirus-related disease.
authors.affiliation: Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Xiaozhan
authors.initials: X
authors.lastname: Liang
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Crepeau
authors.forename: Weijun
authors.initials: W
authors.lastname: Zhang
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Speck
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Usherwood
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000821:virology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D045744:Cell Line, Tumor; D002472:Cell Transformation, Viral; D051379:Mice; D008810:Mice, Inbred C57BL; D018144:Rhadinovirus / Q000472:pathogenicity*