title: Postprandial effects of calcium phosphate supplementation on plasma concentration-double-blind, placebo-controlled cross-over human study.
abstract: BACKGROUND
  The aim of the present study was to examine the postprandial calcium and phosphate concentrations after supplementation with pentacalcium hydroxy-triphosphate (CaP).
  
  
  METHODS
  Ten men participated in this double-blind, placebo-controlled, cross-over study. The participants were divided into two groups. One group consumed bread enriched with CaP (plus 1 g calcium/d) and the other group a placebo product for three weeks. After a two week wash-out, the intervention was switched between the groups for another three weeks. Blood samples were drawn at the beginning (single administration) and at the end (repeated administration) of the intervention periods at 0, 30, 60, 120, 180 and 240 min. Between 0 and 30 min, a test meal, with or without CaP was consumed. The plasma concentrations of calcium and phosphate were examined. One participant dropped out due to personal reasons.
  
  
  RESULTS
  CaP supplementation resulted in a significantly higher plasma calcium concentration after 240 min compared to placebo. After repeated CaP administration, the AUC for the increment in plasma calcium concentration was significantly higher compared to placebo.After single and repeated CaP supplementation, plasma phosphate concentration significantly decreased after 30, 60, 120 and 180 min compared to 0 min. The placebo administration resulted in significant decreases after 30, 60 and 120 min compared to 0 min.
  
  
  CONCLUSIONS
  Our results show that CaP contributes to an adequate calcium supply, but without increasing the plasma concentration of phosphate.
  
  
  BACKGROUND
  www.clinicaltrials.gov; NCT01296997.
authors.affiliation: Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Strasse 24, Jena D-07743, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Trautvetter
authors.forename: Michael
authors.initials: M
authors.lastname: Kiehntopf
authors.forename: Gerhard
authors.initials: G
authors.lastname: Jahreis
mesh_terms: D000328:Adult; D002118:Calcium / Q000097:blood; D002130:Calcium Phosphates / Q000008:administration & dosage* / Q000097:blood*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D010710:Phosphates / Q000097:blood; D019518:Postprandial Period / Q000187:drug effects*; D055815:Young Adult
chemical_list: D002130:Calcium Phosphates; D010710:Phosphates; C020243:calcium phosphate; D002118:Calcium