title: Sibling embryo blastocyst development as a prognostic factor for the outcome of day-3 embryo transfer.
abstract: This study assessed the development of sibling embryos to blastocyst as a prognostic factor for patients undergoing embryo transfer at day 3. A retrospective analysis of a clinical and embryology database including 353 patients who underwent 393 cycles of intracytoplasmic sperm injection with day-3 embryo transfer and excess embryos, maintained in culture until day 5, was performed. Cycles were divided into group A and group B (with and without blastocyst formation, respectively). Age and basal FSH were similar in both groups. Statistically significant differences in clinical pregnancy rates (55.8% versus 40.6%; P=0.0031), live birth rates (50.0% versus 37.2%; P=0.012) and implantation rates (34.2% versus 23.7%; P=0.0035) were observed in groups A and B, respectively. Odds ratios showed women from group A had 1.85- and 1.68-times the odds of patients from group B of achieving clinical pregnancy and a live birth, respectively. Cumulative live birth rate for group A, after one cycle of vitrified-warmed blastocyst transfer, was 66.4%. The development of sibling embryos to blastocyst is a prognostic factor for the outcome of the cycle in which transfer is performed at day 3 and provides valuable information about the prognosis of subsequent cycles.
authors.affiliation: Unit of Reproductive Medicine, Department of Obstetrics and Gynecology, Clinica Las Condes, Chile. amackenn@clc.cl
authors.forename: Antonio
authors.initials: A
authors.lastname: Mackenna
authors.forename: Javier
authors.initials: J
authors.lastname: Crosby
authors.forename: Fernando
authors.initials: F
authors.lastname: Zegers-Hochschild
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000502:physiology*; D004624:Embryo Transfer / Q000379:methods*; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D006801:Humans; D050498:Live Birth; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D011379:Prognosis; D012189:Retrospective Studies; D035781:Siblings; D020554:Sperm Injections, Intracytoplasmic