title: Effects of a low-carbohydrate diet on weight loss and cardiometabolic profile in Chinese women: a randomised controlled feeding trial.
abstract: Little is known about the potential adherence to and the effectiveness of a low-carbohydrate (LC) diet on weight loss and cardiometabolic risk factors in Chinese adults with a habitually high carbohydrate intake. In the present controlled feeding trial, fifty overweight or obese women (age 47·9 (sem 0·9) years; BMI 26·7 (sem 0·3) kg/m²) were randomly assigned to a LC non-energy-restricted diet (initial carbohydrate intake 20 g/d, with a 10 g increase weekly) or an energy-restricted (ER) diet (carbohydrate intake 156-205 g/d, ER to 5021 or 6276 kJ/d, 35% average energy reduction) for 12 weeks. Over the intervention period, the two diets had comparable compliance (96%) and self-reported acceptability. At week 12, carbohydrate intake in the LC and ER groups contributed to 36·1 and 51·1% of total energy, respectively (P < 0·001). Although both diets showed similarly decreased mean body weight (LC - 5·27 (95% CI - 6·08, - 4·46) kg; ER - 5·09 (95% CI - 5·50, - 4·67) kg, P = 0·67) and percentage of fat mass measured by dual-energy X-ray absorptiometry (LC - 1·19 (95% CI - 1·88, - 0·50)%; ER - 1·56 (95% CI - 2·20, - 0·92)%, P = 0·42), participants in the LC group had greater reductions in the ratio of total cholesterol:HDL-cholesterol (P= 0·03) and also in the ratio of TAG:HDL-cholesterol (P = 0·01) than those in the ER group. The present 12-week diet trial suggested that both a LC non-energy-restricted diet and an ER diet were acceptable to Chinese women and both diets were equally effective in reducing weight and fat mass. Moreover, the LC diet showed beneficial effects on blood lipid profiles.
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, 294 Tai-Yuan Road, Shanghai 200031, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Geng
authors.initials: G
authors.lastname: Zhang
authors.forename: Xingwang
authors.initials: X
authors.lastname: Ye
authors.forename: Huaixing
authors.initials: H
authors.lastname: Li
authors.forename: Xiafei
authors.initials: X
authors.lastname: Chen
authors.forename: Lixin
authors.initials: L
authors.lastname: Tang
authors.forename: Ying
authors.initials: Y
authors.lastname: Feng
authors.forename: Iris
authors.initials: I
authors.lastname: Shai
authors.forename: Meir J
authors.initials: MJ
authors.lastname: Stampfer
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Xu
authors.initials: X
authors.lastname: Lin
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D002241:Carbohydrates / Q000008:administration & dosage*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002319:Cardiovascular System; D002681:China; D008076:Cholesterol, HDL / Q000032:analysis; D050528:Diet, Carbohydrate-Restricted; D005260:Female; D006801:Humans; D008875:Middle Aged; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D002241:Carbohydrates; D008076:Cholesterol, HDL