title: [Assessment of the risk of the transition of a monofocal clinically isolated syndrome to clinically definite multiple sclerosis].
abstract: We followed up 102 patients with a monofocal clinically isolated syndrome (CIS) during 8 years. Factors determining its transition to definite multiple sclerosis were singled out according to the data of anamnesis and MRI scans. Age of patients at the onset of CIS and the volume of demyelination measured by the first MRI were the most significant predictors of the transition of CIS to definite multiple sclerosis. A mathematical model based on logistic regression analysis for the estimation of the risk of this transition is suggested.
authors.forename: A V
authors.initials: AV
authors.lastname: Zakharov
authors.forename: E V
authors.initials: EV
authors.lastname: Khinivtseva
authors.forename: I E
authors.initials: IE
authors.lastname: Poverennova
authors.forename: E A
authors.initials: EA
authors.lastname: Gindullina
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Vlasov
authors.forename: E V
authors.initials: EV
authors.lastname: Sineok
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D003711:Demyelinating Diseases / Q000150:complications / Q000175:diagnosis*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D013116:Spinal Cord / Q000473:pathology*; D013577:Syndrome; D013997:Time Factors; D055815:Young Adult