title: PAX5 alteration-associated gene-expression signatures in B-cell acute lymphoblastic leukemia.
abstract: The paired box domain gene 5 (PAX5) is frequently altered in both childhood and adult B-cell acute lymphoblastic leukemia, and takes part in leukemogenesis. We analyzed data from the database of Gene Expression Omnibus (accession number: GSE11877) using bioinformatical and statistical methods. The results showed that cases of PAX5 alteration can cluster using unsupervised clustering algorithms, and one gene, zinc and ring finger 1 (ZNRF1), was characterized and validated by quantitative RT-PCR. ZNRF1 may be associated with leukemogenesis of ALL with PAX5 alteration.
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Da Dao, Wuhan 430030, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Shang
authors.forename: Yuechao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Kuangguo
authors.initials: K
authors.lastname: Zhou
authors.forename: Yanling
authors.initials: Y
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
mesh_terms: D002352:Carrier Proteins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D005260:Female; D020869:Gene Expression Profiling; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007223:Infant; D008297:Male; D051757:PAX5 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000378:metabolism; D059467:Transcriptome; D044767:Ubiquitin-Protein Ligases
chemical_list: D002352:Carrier Proteins; D051757:PAX5 Transcription Factor; D044767:Ubiquitin-Protein Ligases; C544744:ZNRF1 protein, human