title: Anti-inflammatory effects of arsenic trioxide eluting stents in a porcine coronary model.
abstract: Previous research from our group has demonstrated arsenic trioxide eluting stents significantly reduced neointimal area and thickness compared with bare metal stents. In the present study, the anti-inflammatory effects of arsenic trioxide in vitro and arsenic trioxide eluting stents in a porcine coronary model have been explored. Sixty-five pigs underwent placement of 139 oversized stents in the coronary arteries with histologic analysis, endothelial function analysis, and immunohistochemical and western blot analyses. Arsenic trioxide eluting stents effectively inhibited local inflammatory reactions, while no significant difference in endothelialization and endothelial function between arsenic trioxide eluting stents and bare metal stents was observed. Arsenic trioxide eluting stents favorably modulate neointimal formation due to less augmentation of early inflammatory reactions, and quick endothelialization of the stent surface, which might contribute to long-term safety and efficacy of drug eluting stents.
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: Feirong
authors.initials: F
authors.lastname: Gong
authors.forename: Wenjie
authors.initials: W
authors.lastname: Tian
authors.forename: Weiming
authors.initials: W
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Juying
authors.initials: J
authors.lastname: Qian
authors.forename: Aijun
authors.initials: A
authors.lastname: Sun
authors.forename: Yunzeng
authors.initials: Y
authors.lastname: Zou
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Junbo
authors.initials: J
authors.lastname: Ge
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017209:Apoptosis; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000008:administration & dosage / Q000494:pharmacology*; D002453:Cell Cycle; D003331:Coronary Vessels / Q000187:drug effects* / Q000473:pathology; D054855:Drug-Eluting Stents; D006321:Heart / Q000187:drug effects; D007249:Inflammation; D008297:Male; D009206:Myocardium / Q000473:pathology; D010087:Oxides / Q000008:administration & dosage / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry; D013552:Swine; D017539:Tunica Intima / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D001152:Arsenicals; D010087:Oxides; D011108:Polymers; D000077237:Arsenic Trioxide