title: Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators.
abstract: In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-β), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.
authors.affiliation: School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands. evelyn.peelen@maastrichtuniversity.nl
authors.forename: E
authors.initials: E
authors.lastname: Peelen
authors.forename: M
authors.initials: M
authors.lastname: Thewissen
authors.forename: S
authors.initials: S
authors.lastname: Knippenberg
authors.forename: J
authors.initials: J
authors.lastname: Smolders
authors.forename: A-H
authors.initials: AH
authors.lastname: Muris
authors.forename: P
authors.initials: P
authors.lastname: Menheere
authors.forename: J W Cohen
authors.initials: JW
authors.lastname: Tervaert
authors.forename: R
authors.initials: R
authors.lastname: Hupperts
authors.forename: J
authors.initials: J
authors.lastname: Damoiseaux
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016899:Interferon-beta / Q000627:therapeutic use; D016753:Interleukin-10 / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy / Q000276:immunology*; D010455:Peptides / Q000627:therapeutic use; D011863:Radioimmunoassay; D012008:Recurrence; D012074:Remission Induction; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014807:Vitamin D / Q000097:blood
chemical_list: D007166:Immunosuppressive Agents; D020381:Interleukin-17; D010455:Peptides; D016753:Interleukin-10; D014807:Vitamin D; D000068717:Glatiramer Acetate; D016899:Interferon-beta