title: The use of DWI to assess spleen and liver quantitative ADC changes in the detection of liver fibrosis stages in chronic viral hepatitis.
abstract: This study aimed to evaluate the changes in spleen and liver diffusion-weighted magnetic resonance imaging (DWI) in chronic viral hepatitis patients. The study comprised 47 patients and 30 healthy volunteers. DWIs were obtained. Apparent Diffusion Coefficient (ADC) measurements were made by transferring the images to the workstation. The measurements of value b 1000 were made from a total of five points of the liver and three points of the spleen. Liver biopsy was performed on the 47 patients. The fibrosis stages of the patients were defined according to the METAVIR scoring system. Student's t-test was used in the comparison of mean ages, liver and spleen ADC values between the patient and the control group. Kruskal-Wallis followed by Mann-Whitney U Test with Bonferroni adjustment was performed in the comparison of mean ADC values of the patients at different stages and the control group. A statistically significant difference was determined between the patient and control group in respect of liver and spleen mean ADC values (P<0.05). F3 group showed a significant difference compared to control and F1 and F4 group showed a significant difference compared to control, F1, F2 and F3 group in terms of the mean liver ADC value (P<0.01). F3 and F4 group showed a significant difference compared to control and F1 group in terms of the mean spleen ADC value (P<0.01). As a result we believe that the measurement of liver and spleen ADC values may be an indicator in the determination of the level of fibrosis.
authors.affiliation: Harran University, Faculty of Medicine, Department of Radiology, Sanliurfa, Turkey. hasan_cece@yahoo.com
authors.forename: Hasan
authors.initials: H
authors.lastname: Cece
authors.forename: Abdulbasit
authors.initials: A
authors.lastname: Ercan
authors.forename: Sema
authors.initials: S
authors.lastname: Yıldız
authors.forename: Ekrem
authors.initials: E
authors.lastname: Karakas
authors.forename: Omer
authors.initials: O
authors.lastname: Karakas
authors.forename: Fatıma Nurefsan
authors.initials: FN
authors.lastname: Boyacı
authors.forename: Timucin
authors.initials: T
authors.lastname: Aydogan
authors.forename: Emel Yigit
authors.initials: EY
authors.lastname: Karakas
authors.forename: Nesat
authors.initials: N
authors.lastname: Cullu
authors.forename: Turgay
authors.initials: T
authors.lastname: Ulas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013154:Spleen / Q000473:pathology*; D055815:Young Adult