title: Reference intervals of serum cystatin C for determining cystatin C-based glomerular filtration rates in preterm neonates.
abstract: OBJECTIVE
  The aim of this study is to determine the reference values of serum Cystatin C (CysC) and CysC-based estimated glomerular filtration rate (GFR) on the 3rd and 30th day of life in comparison with serum creatinine (Cr) and Cr-based estimated GFR.
  
  
  METHODS
  This prospective study was performed on 52 preterm neonates whose gestational ages were between 28 and 34 weeks. Preterm neonates were divided into three groups according to the gestational age as follows: gestational week of 28-29 (group 1), gestational week of 30-32 (group 2) and gestational week of 33-34 (group 3). Blood samples were obtained on the 3rd and the 30th days of life. CysC was determined by particle-enhanced nephelometric immunoassay.
  
  
  RESULTS
  The group 1 preterm neonates have higher CysC values (1.34 ± 0.1 mg/L) on the 3rd day of life than the group 2 (1.28 ± 0.2 mg/L) and the group 3 (1.24 ± 0.2 mg/L) but the differences were not significant (p > 0.05, for each). CysC values were independent of gestational age, birth weight and gender (p > 0.05, for each). No correlation was found between CysC and Cr on the 3rd day of life (p > 0.05).
  
  
  CONCLUSIONS
  CysC is regarded as an alternative for assessing the renal function in preterm neonates.
authors.affiliation: Department of Pediatric Nephrology, Faculty of Medicine, University of Inonu .
authors.forename: Ahmet Taner
authors.initials: AT
authors.lastname: Elmas
authors.forename: Yılmaz
authors.initials: Y
authors.lastname: Tabel
authors.forename: Ozlem Nalbantoğlu
authors.initials: ON
authors.lastname: Elmas
mesh_terms: D001724:Birth Weight; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005865:Gestational Age; D005919:Glomerular Filtration Rate; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D015931:Intensive Care, Neonatal; D007677:Kidney Function Tests; D008297:Male; D011446:Prospective Studies; D012016:Reference Values
chemical_list: D055316:Cystatin C; D003404:Creatinine