title: A convenient synthesis of N-linked diglycose derivatives based on one-pot tandem Staudinger/aza-Wittig/reduction and biological evaluation.
abstract: A series of novel N-linked diglycose derivatives 9 and 10 were conveniently and directly synthesized based on the key step of one-pot tandem Staudinger/aza-Wittig/reduction reaction from the azido sugar and sugar-derived aldehyde followed by deprotection. The biological activities against glycosidases (α-amylase, α-glucosidase, and β-glucosidase) and HIV-RT and antitumor activity of these compounds were preliminarily evaluated.
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, School of Chemistry and Environmental Science, Hebei University, Baoding, Hebei 071002, China.
authors.forename: Pingzhu
authors.initials: P
authors.lastname: Zhang
authors.forename: Yinbo
authors.initials: Y
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Wang
authors.forename: Cuicui
authors.initials: C
authors.lastname: Li
authors.forename: Donglai
authors.initials: D
authors.lastname: Ma
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.forename: Kerang
authors.initials: K
authors.lastname: Wang
authors.forename: Xiaoliu
authors.initials: X
authors.lastname: Li
authors.forename: Jinchao
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D060326:Chemistry Techniques, Synthetic; D004186:Disaccharidases / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
chemical_list: D000447:Aldehydes; D000588:Amines; D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D054303:HIV Reverse Transcriptase; D004186:Disaccharidases; D000516:alpha-Amylases