title: Niacin inhibits carrageenan-induced neutrophil migration in mice.
abstract: Several emerging lines of evidence support an anti-inflammatory role for nicotinic acid (niacin); however, its role in the regulation of leukocyte migration in response to inflammatory stimuli has not been elucidated until now. Herein, we have examined the effect of nicotinic acid on neutrophil recruitment in experimentally induced inflammation. We demonstrated that nicotinic acid treatment inhibited interleukin (IL)-8-induced, leukotriene (LT)B4-induced, and carrageenan-induced neutrophil migration into the pleural cavity of BALB/c mice and reduced neutrophil rolling and adherence in a mouse cremaster muscle preparation. Surprisingly, nicotinic acid treatment increased the level of the neutrophil chemoattractant KC in response to carrageenan. These results suggest that nicotinic acid plays an important role in the regulation of inflammation due to its ability to inhibit the actions of the neutrophil chemoattractants IL-8 and LTB4. Further inhibition of chemoattractants leads to impairment of leukocyte rolling and adherence to the vascular endothelium in the microcirculation of inflamed tissues.
authors.affiliation: Laboratory of Inflammation and Pain, Institute of Biological Sciences, UFMG, Belo Horizonte, Brazil.
authors.forename: Raphael Gomes
authors.initials: RG
authors.lastname: Ferreira
authors.forename: Tamires Cardoso
authors.initials: TC
authors.lastname: Matsui
authors.forename: Lindisley Ferreira
authors.initials: LF
authors.lastname: Gomides
authors.forename: Adriana Martins
authors.initials: AM
authors.lastname: Godin
authors.forename: Gustavo Batista
authors.initials: GB
authors.lastname: Menezes
authors.forename: Márcio
authors.initials: M
authors.lastname: de Matos Coelho
authors.forename: André
authors.initials: A
authors.lastname: Klein
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D054360:Chemokine CXCL1 / Q000378:metabolism; D004195:Disease Models, Animal; D007154:Immune System Diseases / Q000517:prevention & control*; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology; D016209:Interleukin-8 / Q000494:pharmacology; D007960:Leukocyte Disorders / Q000517:prevention & control*; D036904:Leukocyte Rolling / Q000187:drug effects; D007975:Leukotriene B4 / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D020556:Neutrophil Infiltration / Q000187:drug effects; D009525:Niacin / Q000494:pharmacology*; D035422:Pleural Cavity / Q000187:drug effects / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D054360:Chemokine CXCL1; C475895:Cxcl1 protein, mouse; D016209:Interleukin-8; D007975:Leukotriene B4; D009525:Niacin; D002351:Carrageenan