title: Propofol compared with combination propofol or midazolam/fentanyl for endoscopy in a community setting.
abstract: This retrospective cohort study evaluated procedural efficiency and patient satisfaction in patients who had received propofol, midazolam/fentanyl/propofol (MFP), or midazolam/fentanyl, as sedation for either esophagogastroduodenoscopy or colonoscopy. Questionnaires about procedural times and patient satisfaction were administered. Use of propofol for colonoscopy resulted in shorter time (minutes) from induction to start of procedure (mean +/- standard deviation: propofol, 1.3 +/- 0.57; MFP, 3.2 +/- 2.2; midazolam/fentanyl, 3.8 +/- 2.7; P < .04) and shorter procedure time (propofol, 13 +/- 0.36; MFP, 15 +/- 0.004; midazolam/fentanyl, 75 +/- 0.005 minutes; P < .05). Recovery time was less for patients receiving propofol for their colonoscopy compared with the other groups (propofol, 9 +/- 8; MFP, 15 +/- 9; midazolam/ fentanyl, 18 +/- 117 minutes; P < .05). Patients undergoing esophagogastroduodenoscopy who received propofol had a shorter recovery time (9 +/- 7 minutes vs MFP, 14 +/- 9 minutes, and midazolam/fentanyl, 19 +/- 11 minutes; P < .05). Patients receiving propofol felt less discomfort and need for adjustment in the sedation, and remembered less of the procedure compared with the MFP group. Propofol resulted in less time in the endoscopy unit, quicker recovery and discharge, and greater patient satisfaction than did balanced or conscious sedation.
authors.affiliation: Fayetteville Gastroenterology Associates, North Carolina, USA. poulosj@pol.net
authors.forename: John E
authors.initials: JE
authors.lastname: Poulos
authors.forename: Peter T
authors.initials: PT
authors.lastname: Kalogerinis
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Caudle
mesh_terms: D000762:Anesthesia Recovery Period; D003113:Colonoscopy; D004359:Drug Therapy, Combination; D016145:Endoscopy, Digestive System; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D008875:Middle Aged; D017060:Patient Satisfaction; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D012189:Retrospective Studies
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam; D005283:Fentanyl; D015742:Propofol