title: Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women.
abstract: In previous studies of postmenopausal women, overall intake of fruits and vegetables groups has been inversely associated with estrogen receptor-negative (ER-) breast cancer. In this analysis, we prospectively examined the associations of specific fruits and vegetables with risk of ER- postmenopausal breast cancer among 75,929 women aged 38-63 years at baseline and followed for up to 24 years. Dietary data were collected seven times during this period. Cox proportional hazard models were used, adjusting for potential confounders, including a modified Alternate Mediterranean Diet score. We ascertained 792 incident cases of ER- postmenopausal breast cancer. The multivariate relative risk (RR) for every 2 servings/week consumption for total berries was 0.82 (95 % CI = 0.71-0.96, p = 0.01), and the RR for women who consumed at least one serving of blueberries a week was 0.69 (95 % CI = 0.50-0.95, p = 0.02) compared with non-consumers. Also, the RR for consuming at least 2 servings of peaches/nectarines per week was 0.59 (95 % CI = 0.37-0.93, p = 0.02). Risk of ER- breast cancer was not associated with intakes of other specific fruits or vegetables. In conclusion, higher intake of berries and peaches was associated with lower risk of ER- breast cancer among postmenopausal women. These results are considered exploratory and need to be confirmed in further studies.
authors.affiliation: Department of Nutrition, Simmons College, 300 The Fenway, Boston, MA 02115, USA. fung@simmons.edu
authors.forename: Teresa T
authors.initials: TT
authors.lastname: Fung
authors.forename: Stephanie E
authors.initials: SE
authors.lastname: Chiuve
authors.forename: Walter C
authors.initials: WC
authors.lastname: Willett
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Holmes
mesh_terms: D000328:Adult; D029798:Blueberry Plants; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology; D004032:Diet; D005260:Female; D005500:Follow-Up Studies; D005638:Fruit; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D017698:Postmenopause; D016016:Proportional Hazards Models; D011446:Prospective Studies; D027861:Prunus; D011960:Receptors, Estrogen / Q000378:metabolism*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014481:United States; D014675:Vegetables
chemical_list: D011960:Receptors, Estrogen