title: [3D MRI-based brachytherapy in patients with locally advanced cervical carcinoma - early clinical results].
abstract: OBJECTIVE
  To demonstrate the clinical benefit of MRI-based brachytherapy using CT and MRI data fusion.
  
  
  METHODS
  Clinical trial.
  
  
  METHODS
  Oncology Centre, Multiscan and Pardubice Regional Hospital, Pardubice.
  
  
  METHODS
  Thirty six patients with locally advanced cervical cancer were treated with MRI-based brachytherapy (MRI-based preplanning 15 patients, MRI approximation 21 patients). All patients were continuously followed during and after treatment. Tumor control and toxicity were evaluated at each visit. Late gastrointestinal and genitourinary symptoms were recorded, using Fox Chase (FC) modification of the Radiation Therapy Oncology Group (RTOG) and Late Effects Normal Tissue Task Force (LENT) toxicity criteria.
  
  
  RESULTS
  We observed no complications during the entire MRI procedure at the radiology department. The cumulative incidence of grade 2 late genitourinary and gastrointestinal toxicity at median follow up of 30.3 months was 4.8% and 9.5% for MRI approximation, respectively 0% and 13.3% for MRI-based preplanning. Local control was 86.7% for MRI-based preplanning and 76.2% for MRI approximation.
  
  
  CONCLUSIONS
  3D MRI-based brachytherapy with consecutive CT/MRI data fusion yields excellent local control with minor toxicity.
authors.affiliation: Pardubicka krajska nemocnice, Pardubice. dolezelm@email.cz
authors.forename: M
authors.initials: M
authors.lastname: Doležel
authors.forename: J
authors.initials: J
authors.lastname: Vaňásek
authors.forename: K
authors.initials: K
authors.lastname: Odrážka
authors.forename: T
authors.initials: T
authors.lastname: Kroulík
authors.forename: K
authors.initials: K
authors.lastname: Kudelka
authors.forename: M
authors.initials: M
authors.lastname: Tichý
authors.forename: M
authors.initials: M
authors.lastname: Košťál
authors.forename: Z
authors.initials: Z
authors.lastname: Vocásek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D002277:Carcinoma / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D053783:Magnetic Resonance Imaging, Interventional; D008875:Middle Aged; D011880:Radiotherapy Planning, Computer-Assisted; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*