title: Chronic alcohol ingestion changes the landscape of the alveolar epithelium.
abstract: Similar to effects of alcohol on the heart, liver, and brain, the effects of ethanol (EtOH) on lung injury are preventable. Unlike other vital organ systems, however, the lethal effects of alcohol on the lung are underappreciated, perhaps because there are no signs of overt pulmonary disorder until a secondary insult, such as a bacterial infection or injury, occurs in the lung. This paper provides overview of the complex changes in the alveolar environment known to occur following both chronic and acute alcohol exposures. Contemporary animal and cell culture models for alcohol-induced lung dysfunction are discussed, with emphasis on the effect of alcohol on transepithelial transport processes, namely, epithelial sodium channel activity (ENaC). The cascading effect of tissue and phagocytic Nadph oxidase (Nox) may be triggered by ethanol exposure, and as such, alcohol ingestion and exposure lead to a prooxidative environment; thus impacting alveolar macrophage (AM) function and oxidative stress. A better understanding of how alcohol changes the landscape of the alveolar epithelium can lead to improvements in treating acute respiratory distress syndrome (ARDS) for which hospitalized alcoholics are at an increased risk.
authors.affiliation: Department of Pediatrics, Emory-Children Center for Developmental Lung Biology, 2015 Uppergate Drive, Suite 316K, Atlanta, GA 30322, USA.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Downs
authors.forename: David
authors.initials: D
authors.lastname: Trac
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Brewer
authors.forename: Lou Ann
authors.initials: LA
authors.lastname: Brown
authors.forename: My N
authors.initials: MN
authors.lastname: Helms
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D000434:Alcoholic Beverages / Q000009:adverse effects; D000437:Alcoholism / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D004848:Epithelium / Q000187:drug effects* / Q000503:physiopathology; D000431:Ethanol / Q000009:adverse effects; D006801:Humans; D007249:Inflammation; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D016676:Macrophages, Alveolar / Q000187:drug effects; D018384:Oxidative Stress; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000628:therapy; D015398:Signal Transduction
chemical_list: D000431:Ethanol