title: Hormonal receptors in skeletal muscles of dystrophic mdx mice.
abstract: BACKGROUND
  Several evidences show that muscles have an endocrine function. Glucocorticoid, estrogen, progesterone, and testosterone receptors have already been found in normal skeletal muscles, but not in dystrophic muscles.
  
  
  METHODS
  The gene expression of hormone receptors was compared between dystrophic and healthy muscles in mdx and C57BL6 mice strains.
  
  
  RESULTS
  The mdx mice showed a significant increase in the steroid receptors mRNA when compared to the C57BL6 mice: levels of androgen(s) receptors in the heart, estrogen receptors alpha in the EDL, and estrogen receptors beta in the quadriceps were increased. In addition, significant lowered levels of some other hormone receptors were found: corticosteroid receptors in the EDL and estrogen receptors alpha in the quadriceps.
  
  
  CONCLUSIONS
  Dystrophic muscles bear significant differences in the expression of hormone receptors when compared to the C57BL6 mice strain. The importance of such differences is yet to be better understood.
authors.affiliation: Department of Pharmacology, ABC Medical School, FMABC, Avenue Príncipe de Gales 821, 09060-650 Santo Andre, SP, Brazil.
authors.forename: David
authors.initials: D
authors.lastname: Feder
authors.forename: Ivan
authors.initials: I
authors.lastname: Rodrigues Barros Godoy
authors.forename: Maira Lazzarini
authors.initials: ML
authors.lastname: Guimarães Pereira
authors.forename: Cledson Silveira
authors.initials: CS
authors.lastname: Silva
authors.forename: Diego
authors.initials: D
authors.lastname: Nogueira Silvestre
authors.forename: Fernando Luiz Affonso
authors.initials: FL
authors.lastname: Fonseca
authors.forename: Alzira
authors.initials: A
authors.lastname: Alves de Siqueira Carvalho
authors.forename: Rosangela
authors.initials: R
authors.lastname: Aparecida dos Santos
authors.forename: Maria Helena
authors.initials: MH
authors.lastname: Catteli Carvalho
mesh_terms: D000818:Animals; D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018101:Mice, Inbred mdx; D018482:Muscle, Skeletal / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D011944:Receptors, Androgen; D011960:Receptors, Estrogen