title: Bioavailability of quercetin: problems and promises.
abstract: Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including antiinflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.
authors.forename: X
authors.initials: X
authors.lastname: Cai
authors.forename: Z
authors.initials: Z
authors.lastname: Fang
authors.forename: J
authors.initials: J
authors.lastname: Dou
authors.forename: A
authors.initials: A
authors.lastname: Yu
authors.forename: G
authors.initials: G
authors.lastname: Zhai
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001682:Biological Availability; D004337:Drug Carriers / Q000737:chemistry; D006207:Half-Life; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry / Q000493:pharmacokinetics; D011794:Quercetin / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D008081:Liposomes; D008823:Micelles; D011355:Prodrugs; D011794:Quercetin