title: Relationship between methyl CpG binding protein 2 and JC viral proteins.
abstract: JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.
authors.affiliation: Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Orba
authors.forename: Taichi
authors.initials: T
authors.lastname: Kimura
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Shinji
authors.initials: S
authors.lastname: Kohsaka
authors.forename: Masumi
authors.initials: M
authors.lastname: Tsuda
authors.forename: Mishie
authors.initials: M
authors.lastname: Tanino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishihara
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagashima
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sawa
authors.forename: Shinya
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D002460:Cell Line; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D007577:JC Virus / Q000472:pathogenicity*; D051783:Methyl-CpG-Binding Protein 2 / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D014764:Viral Proteins / Q000096:biosynthesis*
chemical_list: D051783:Methyl-CpG-Binding Protein 2; D012333:RNA, Messenger; D014764:Viral Proteins