title: The efficacy of cardiac findings in assessing the outcome in preterms with bronchopulmonary dysplasia.
abstract: OBJECTIVE
  To evaluate if cardiac dysfunctions are important in assessing the outcome in newborns with Bronchopulmonary Dysplasia (BPD), by evaluating cardiac functions with N-terminal prohormone of brain natriüretic peptide (NT-proBNP) levels, M-mode and tissue doppler echocardiography at 6-12 mo of age.
  
  
  METHODS
  Twenty eight patients were retrospectively classified as mild, moderate and severe according to the diagnostic criterias for BPD. All cases were assessed with standard M-mode, tissue doppler echocardiography and NT-proBNP levels. Control group consisted of 28 healthy infants, having similar postnatal ages as patients and were assessed with standard M-mode and tissue doppler echocardiography.
  
  
  RESULTS
  The age of patients with BPD was 9.8 ± 2.3 mo and control group was 9.5 ± 2.6 mo. There was no significant difference between the postnatal ages of two groups (p > 0.05). Neither pulmonary hypertension nor pulmonary/tricuspid regurgitation was detected. The M-mode echocardiography measurements did not differ between patients and control group (p > 0.05). Tissue doppler echocardiography, tricuspid valve medial segment early diastolic myocardial relaxation velocity (TME') measurements of patients were found significantly lower, peak transtricuspid filling velocity in the early diastole (TE)/TME' ratios and isovolumetric relaxation time (IVRT) measurements were found significantly higher than control group (p < 0.05). Tricuspid E, TE/TLE' (Tricuspid valve lateral segment early diastolic myocardial relaxation velocity), TE/RVLE'(Right ventricular lateral segment early diastolic myocardial relaxation velocity), TE/TME' levels were also found as significantly abnormal in patients with severe BPD. A significant correlation was found between right ventricular diastolic disfunctions and severity of BPD (p < 0.05). No statistically significant difference was found between NT-proBNP levels, BPD stages and tissue doppler echocardiography measurements (p > 0.05).
  
  
  CONCLUSIONS
  This is the first study evaluating cardiac findings in patients with BPD by tissue doppler echocardiography and NT-proBNP at the same time. On the basis of cardiac evaluations, tissue doppler echocardiography measurements were found as significant and specific for the early assessment of right ventricular diastolic disfunctions.
authors.affiliation: Department of Pediatrics, Division of Neonatology, Akdeniz University, School of Medicine, 07070, Antalya, Turkey, barisakc@hotmail.com.
authors.forename: Abdullah Barış
authors.initials: AB
authors.lastname: Akcan
authors.forename: Fırat
authors.initials: F
authors.lastname: Kardelen
authors.forename: Seyhan Erişir
authors.initials: SE
authors.lastname: Oygucu
authors.forename: Abdullah
authors.initials: A
authors.lastname: Kocabaş
authors.forename: Deniz
authors.initials: D
authors.lastname: Ozel
authors.forename: Halide
authors.initials: H
authors.lastname: Akbaş
authors.forename: Nihal
authors.initials: N
authors.lastname: Oygür
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000000981:diagnostic imaging* / Q000628:therapy; D004452:Echocardiography; D006801:Humans; D007223:Infant; D007234:Infant, Premature; D012189:Retrospective Studies; D016896:Treatment Outcome