title: Checkpoint kinase 1 in DNA damage response and cell cycle regulation.
abstract: Originally identified as a mediator of DNA damage response (DDR), checkpoint kinase 1 (Chk1) has a broader role in checkpoint activation in DDR and normal cell cycle regulation. Chk1 activation involves phosphorylation at conserved sites. However, recent work has identified a splice variant of Chk1, which may regulate Chk1 in both DDR and normal cell cycle via molecular interaction. Upon activation, Chk1 phosphorylates a variety of substrate proteins, resulting in the activation of DNA damage checkpoints, cell cycle arrest, DNA repair, and/or cell death. Chk1 and its related signaling may be an effective therapeutic target in diseases such as cancer.
authors.affiliation: Department of Cellular Biology and Anatomy, Georgia Regents University and Charlie Norwood VA Medical Center, 1459 Laney Walker Blvd., Augusta, GA, 30912, USA.
authors.forename: Mallikarjun
authors.initials: M
authors.lastname: Patil
authors.forename: Navjotsingh
authors.initials: N
authors.lastname: Pabla
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dong
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D059447:Cell Cycle Checkpoints; D000071877:Checkpoint Kinase 1; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding; D011494:Protein Kinases / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D013045:Species Specificity
chemical_list: D011494:Protein Kinases; C000605867:CHEK1 protein, human; D000071877:Checkpoint Kinase 1