title: Inter- and intramolecular enantioselective carbolithiation reactions.
abstract: In this review we summarize recent developments in inter- and intramolecular enantioselective carbolithiation reactions carried out in the presence of a chiral ligand for lithium, such as (-)-sparteine, to promote facial selection on a C=C bond. This is an attractive approach for the construction of new carbon-carbon bonds in an asymmetric fashion, with the possibility of introducing further functionalization on the molecule by trapping the reactive organolithium intermediates with electrophiles.
authors.affiliation: Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco / Euskal Herriko Unibertsitatea UPV/EHU, Apdo. 644, 48080 Bilbao, Spain.
authors.forename: Asier
authors.initials: A
authors.lastname: Gómez-Sanjuan
authors.forename: Nuria
authors.initials: N
authors.lastname: Sotomayor
authors.forename: Esther
authors.initials: E
authors.lastname: Lete
keywords: alkenes; asymmetric synthesis; carbolithiation; carbometallation; enantioselectivity; lithium