title: [The role of nitric oxide and taurine in regulation of dogs gastric secretory function].
abstract: The influence of taurine and endogenous nitric oxide on the gastric secretion and secretory process alterations by taurine at the nitric oxide synthesis blockade was investigated in chronic experiments on dogs with gastric fistulas. We determined the intensity of gastric secretion during 1,5 hours and quantitative content of hydrochloric acid, pepsine, total proteins and adenile system components. The NO-synthase inhibition by L-NAME evoked an increase of secreted gastric juice volume stimulated by histamine by 160% (P<0,001), the gastric acid content - by 156,4% (P<0,001), pepsine content - by 184,1% (P<0,001) as compared with control. Taurine increases the volume of gastric juice stimulated by histamine on 129,3% (P<0,001), hydrochloric acid - by 151,4% (P<0,001), pepsine - by 172,2% (P<0,001), total proteins - by 60,5% (P<0,001) as compared with control. Blockade of nitric oxide synthesis did not alter the effect of taurine on histamine gastric secretion. The present results suggest that the endogenous nitric oxide provides an inhibitory influence on gastric secretion and did not participate in realization of regulatory effects of taurine on gastric secretory function.
authors.forename: O A
authors.initials: OA
authors.lastname: Hrinchenko
authors.forename: P I
authors.initials: PI
authors.lastname: Ianchuk
mesh_terms: D000818:Animals; D004285:Dogs; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005747:Gastric Fistula; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010434:Pepsin A / Q000378:metabolism; D013270:Stomach / Q000187:drug effects*; D013654:Taurine / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013654:Taurine; D009569:Nitric Oxide; D006632:Histamine; D019001:Nitric Oxide Synthase; D010434:Pepsin A; D019331:NG-Nitroarginine Methyl Ester