title: Tissue and plasma thioredoxin reductase expressions in patients with glioblastoma multiforme.
abstract: OBJECTIVE
  Thioredoxin reductase (TrxR) is a redox protein that is considered to play a role in tumor progression. The purpose of this study was to assess the expression of TrxR in blood and tumor samples of glioblastoma multiforme (GBM) patients.
  
  
  METHODS
  TrxR levels were evaluated in blood and GBM tissues extracted from 27 patients, in normal brain tissues of 12 autopsy cases, and in blood samples of 12 healthy subjects. The results were compared between tumor and control groups.
  
  
  RESULTS
  The mean level of TrxR in GBM tissues (74.5 ± 14.9 U/g wet tissue) was remarkably higher than in normal brain tissues (14.8 ± 3.4 U/g wet tissue). The mean TrxR levels in blood were significantly higher in GBM patients (296.3 ± 43.6 U/mL) than in the controls (203.0 ± 11.3 U/mL).
  
  
  CONCLUSIONS
  These findings suggest that high levels of TrxR may be related to progression of GBM.
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Rahsan
authors.initials: R
authors.lastname: Kemerdere
authors.forename: Tibet
authors.initials: T
authors.lastname: Kacira
authors.forename: Hakan
authors.initials: H
authors.lastname: Hanimoglu
authors.forename: Mine
authors.initials: M
authors.lastname: Kucur
authors.forename: Taner
authors.initials: T
authors.lastname: Tanriverdi
authors.forename: Bulent
authors.initials: B
authors.lastname: Canbaz
mesh_terms: D000328:Adult; D001344:Autopsy; D005260:Female; D005909:Glioblastoma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D013880:Thioredoxin-Disulfide Reductase / Q000097:blood / Q000378:metabolism*
chemical_list: D013880:Thioredoxin-Disulfide Reductase