title: Permissive hypotension does not reduce regional organ perfusion compared to normotensive resuscitation: animal study with fluorescent microspheres.
abstract: BACKGROUND
  The objective of this study was to investigate regional organ perfusion acutely following uncontrolled hemorrhage in an animal model that simulates a penetrating vascular injury and accounts for prehospital times in urban trauma. We set forth to determine if hypotensive resuscitation (permissive hypotension) would result in equivalent organ perfusion compared to normotensive resuscitation.
  
  
  METHODS
  Twenty four (n=24) male rats randomized to 4 groups: Sham, No Fluid (NF), Permissive Hypotension (PH) (60% of baseline mean arterial pressure - MAP), Normotensive Resuscitation (NBP). Uncontrolled hemorrhage caused by a standardised injury to the abdominal aorta; MAP was monitored continuously and lactated Ringer's was infused. Fluorimeter readings of regional blood flow of the brain, heart, lung, kidney, liver, and bowel were obtained at baseline and 85 minutes after hemorrhage, as well as, cardiac output, lactic acid, and laboratory tests; intra-abdominal blood loss was assessed. Analysis of variance was used for comparison.
  
  
  RESULTS
  Intra-abdominal blood loss was higher in NBP group, as well as, lower hematocrit and hemoglobin levels. No statistical differences in perfusion of any organ between PH and NBP groups. No statistical difference in cardiac output between PH and NBP groups, as well as, in lactic acid levels between PH and NBP. NF group had significantly higher lactic acidosis and had significantly lower organ perfusion.
  
  
  CONCLUSIONS
  Hypotensive resuscitation causes less intra-abdominal bleeding than normotensive resuscitation and concurrently maintains equivalent organ perfusion. No fluid resuscitation reduces intra-abdominal bleeding but also significantly reduces organ perfusion.
authors.affiliation: Federal University of Minas Gerais, Av, Prof, Alfredo Balena 190, Belo Horizonte, MG, 30130-100, Brazil. jbrezende.ufmg@gmail.com.
authors.forename: Bruno M
authors.initials: BM
authors.lastname: Schmidt
authors.forename: Joao B
authors.initials: JB
authors.lastname: Rezende-Neto
authors.forename: Marcus V
authors.initials: MV
authors.lastname: Andrade
authors.forename: Philippe C
authors.initials: PC
authors.lastname: Winter
authors.forename: Mario G
authors.initials: MG
authors.lastname: Carvalho
authors.forename: Thiago A
authors.initials: TA
authors.lastname: Lisboa
authors.forename: Sandro B
authors.initials: SB
authors.lastname: Rizoli
authors.forename: Jose Renan
authors.initials: JR
authors.lastname: Cunha-Melo