title: IFNγ in combination with IL-7 enhances immunotherapy in two rat glioma models.
abstract: Peripheral immunization, using a combination of interferon-gamma (IFNγ)- and interleukin-7 (IL-7)-producing tumor cells, eradicated 75% of pre-established intracerebral N32 rat glioma tumors, and prolonged survival in the more aggressive RG2 model. Rats immunized with IFNγ- and IL7-transduced N32 cells displayed increases in IFNγ plasma levels and proliferating circulating T cells when compared with rats immunized with N32-wild type cells. Following irradiation, the expression of MHC I and II was high on N32-IFNγ cells, but low on RG2-IFNγ cells. In conclusion, IFNγ and IL-7 immunizations prolong survival in two rat glioma models.
authors.affiliation: Division of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden. sara.fritzell@med.lu.se
authors.forename: Sara
authors.initials: S
authors.lastname: Fritzell
authors.forename: Sofia
authors.initials: S
authors.lastname: Eberstål
authors.forename: Emma
authors.initials: E
authors.lastname: Sandén
authors.forename: Edward
authors.initials: E
authors.lastname: Visse
authors.forename: Anna
authors.initials: A
authors.lastname: Darabi
authors.forename: Peter
authors.initials: P
authors.lastname: Siesjö
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000276:immunology*; D004195:Disease Models, Animal; D005910:Glioma / Q000276:immunology*; D007167:Immunotherapy / Q000379:methods*; D007371:Interferon-gamma / Q000008:administration & dosage / Q000276:immunology*; D015851:Interleukin-7 / Q000008:administration & dosage / Q000276:immunology*; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015851:Interleukin-7; D007371:Interferon-gamma