title: Sevoflurane has no adverse effects on renal function in cirrhotic patients: a comparison with propofol.
abstract: BACKGROUND
  Cirrhotic patients are prone to developing renal dysfunction after anaesthesia and surgery. However, no consensus has been reached whether sevoflurane could have adverse effects on renal function in cirrhotic patients. We hypothesised that the use of sevoflurane for general anaesthesia would lead to post-operative renal dysfunction in cirrhotic patients undergoing liver resection.
  
  
  METHODS
  A total of 200 patients undergoing liver resection were randomly assigned to a propofol or sevoflurane group. The influence of sevoflurane or propofol on renal function was evaluated by the maximal change, the difference between the pre-operative baseline and the highest values of serum creatinine and blood urea nitrogen measured at day 1, 3 and 6 post-operatively.
  
  
  RESULTS
  The maximal change in serum creatinine after liver resection was -4.52 (5.78) μmol/l and -3.37 (7.34) μmol/l with P = 0.398, and that in blood urea nitrogen was 0.41 (1.49) mmol/l and 0.93 (1.54) mmol/l with P = 0.098 between the sevoflurane group (n = 52) and the propofol group (n = 50), respectively.
  
  
  CONCLUSIONS
  Sevoflurane does not seem to impair post-operative renal function in cirrhotic patients undergoing liver resection.
authors.affiliation: Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
authors.forename: J-C
authors.initials: JC
authors.lastname: Song
authors.forename: M-Z
authors.initials: MZ
authors.lastname: Zhang
authors.forename: Q-C
authors.initials: QC
authors.lastname: Wu
authors.forename: Z-J
authors.initials: ZJ
authors.lastname: Lu
authors.forename: Y-M
authors.initials: YM
authors.lastname: Sun
authors.forename: L-Q
authors.initials: LQ
authors.lastname: Yang
authors.forename: W-F
authors.initials: WF
authors.lastname: Yu
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000009:adverse effects* / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000009:adverse effects* / Q000494:pharmacology; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005440:Fluid Therapy; D006498:Hepatectomy; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology; D007902:Length of Stay / Q000706:statistics & numerical data; D008103:Liver Cirrhosis / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects* / Q000494:pharmacology; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D015742:Propofol / Q000009:adverse effects* / Q000494:pharmacology; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D003404:Creatinine; D015742:Propofol