title: Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium.
abstract: Lynch syndrome (LS), an autosomal dominant inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colon cancer (HNPCC), is caused by a germline mutation in one of several DNA mismatch repair (MMR) genes. LS is the most common presentation of hereditary colorectal cancer (CRC), accounting for about 2-5% of all CRC cases. More recently, it is found that a similar number of endometrial cancers is also due to one of the MMR gene mutations. There has been significant progress in LS-related CRC in terms of molecular pathogenesis, risks, genetic basis, and cancer prevention. In contrast, the advance about LS-related endometrial cancer (EC) is very much limited. In this commentary, we summarize the main clinicopathologic features of LS-related EC and propose universal screening for LS in individuals with endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Henan Province People’s Hospital Zhengzhou, Henan, China.
authors.forename: Yiying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Janiel
authors.initials: J
authors.lastname: Cragun
authors.forename: Kenneth
authors.initials: K
authors.lastname: Hatch
authors.forename: Setsuko K
authors.initials: SK
authors.lastname: Chambers
authors.forename: Wenxin
authors.initials: W
authors.lastname: Zheng
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000209:etiology; D016889:Endometrial Neoplasms / Q000150:complications* / Q000235:genetics; D005260:Female; D005820:Genetic Testing; D006801:Humans; D011379:Prognosis