title: Cutaneous Mycobacterium intracellulare infection in an immuno-competent person.
abstract: Mycobacterium intracellulare-caused pulmonary infections have mostly been reported in immunocompromised hosts, while cutaneous M. intracellulare infections are rare. We describe here an immunocompetent patient with cutaneous lesions due to M. intracellulare, which was diagnosed by acid-fast staining, in vitro culture, histopathology, and PCR-restriction fragment length polymorphism analysis and gene sequencing of heat-shock protein (hsp) 65 and 16S rDNA genes. In vitro susceptibility testing was also carried out and the patient was successfully treated with clarithromycin, rifampicin, and ethambutol.
authors.affiliation: Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Department of Dermatology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 210042 Nanjing, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhou
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Wang
authors.forename: Su-Ying
authors.initials: SY
authors.lastname: Feng
authors.forename: Qiu-Ling
authors.initials: QL
authors.lastname: Wang
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics; D018834:Chaperonin 60 / Q000235:genetics; D017291:Clarithromycin / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000032:analysis; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000627:therapeutic use; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D021521:Ribotyping; D012293:Rifampin / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D017192:Skin Diseases, Bacterial / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D018834:Chaperonin 60; D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S; C074119:heat-shock protein 65, Mycobacterium; D004977:Ethambutol; D017291:Clarithromycin; D012293:Rifampin