title: Evaluation of effectiveness of osteoporosis treatment in patient with pachydermoperiostosis according to densitometric findings. Case study.
abstract: This study presents the outcome of osteoporosis treatment in a 29-year-old male patient with full-blown Touraine-Solente-Gole syndrome. His first DXA densitometry of the proximal femur demonstrated severe osteoporosis (BMD 0.628 g/cm(2); T-score -3.84 SD, Z-score -3.37 SD). Bisphosphonate treatment (alendronate 70 mg once weekly) produced considerable clinical improvement during a 36-month follow-up. A follow-up densitometry showed a reduction of the osteoporotic indices (BMD 0.665 g/cm(2); T-score -3.54 SD, Z-score -2.93 SD). These findings indicate that it is necessary to treat osteoporosis in pachydermoperiostosis and prevent pathologic bone fractures in these patients.
authors.affiliation: Department of Arthroscopy, Low-Invasive Surgery and Sports Traumatology, Medical University, Łodź, Poland. mwaszczykowski@wp.pl
authors.forename: Michał
authors.initials: M
authors.lastname: Waszczykowski
authors.forename: Jarosław
authors.initials: J
authors.lastname: Fabiś
authors.forename: Tomasz Jacek
authors.initials: TJ
authors.lastname: Zwierzchowski
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Waszczykowska
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D008297:Male; D010004:Osteoarthropathy, Primary Hypertrophic / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates