title: Heparin and carboxymethylchitosan metal nanoparticles: an evaluation of their cytotoxicity.
abstract: In the search for noninvasive diagnostic techniques and new therapies, "nanosystems", which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics.
authors.affiliation: Dipartimento di Biotecnologie e Scienze della Vita, Università dell'Insubria, 21100 Varese, Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Bava
authors.forename: Francesca
authors.initials: F
authors.lastname: Cappellini
authors.forename: Elisa
authors.initials: E
authors.lastname: Pedretti
authors.forename: Federica
authors.initials: F
authors.lastname: Rossi
authors.forename: Enrico
authors.initials: E
authors.lastname: Caruso
authors.forename: Elena
authors.initials: E
authors.lastname: Vismara
authors.forename: Maurizio
authors.initials: M
authors.lastname: Chiriva-Internati
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bernardini
authors.forename: Rosalba
authors.initials: R
authors.lastname: Gornati
mesh_terms: D001672:Biocompatible Materials; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D004337:Drug Carriers; D006493:Heparin / Q000008:administration & dosage* / Q000633:toxicity; D006801:Humans; D007501:Iron / Q000737:chemistry; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000633:toxicity; D046529:Microscopy, Electron, Transmission; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; C514968:carboxymethyl-chitosan; D006493:Heparin; D048271:Chitosan; D007501:Iron