title: A new synthesis route to high surface area sol gel bioactive glass through alcohol washing: a preliminary study.
abstract: Bioactive glass is one of the widely used bone repair material due to its unique properties like osteoconductivity, osteoinductivity and biodegradability. In this study bioactive glass is prepared by the sol gel process and stabilized by a novel method that involves a solvent instead of the conventional calcinations process. This study represents the first attempt to use this method for the stabilization of bioactive glass. The bioactive glass stabilized by this ethanol washing process was characterized for its physicochemical and biomimetic property in comparison with similar composition of calcined bioactive glass. The compositional similarity of the two stabilized glass powders was confirmed by spectroscopic and thermogravimetric analysis. Other physicochemical characterizations together with the cell culture studies with L929 fibroblast cells and bone marrow mesenchymal stem cells proved that the stabilization was achieved with the retention of its inherent bioactive potential. However an increase in the surface area of the glass powder was obtained as a result of this ethanol washing process and this add up to the success of the study. Hence the present study exhibits a promising route for high surface area bioactive glass for increasing biomimicity.
authors.affiliation: Division of Tissue Engineering and Regeneration Technologies; Biomedical Technology Wing; Sree Chitra Tirunal Institute for Medical Sciences and Technology; Thiruvananthapuram, Kerala, India.
authors.forename: Lakshmi M
authors.initials: LM
authors.lastname: Mukundan
authors.affiliation: Division of Tissue Engineering and Regeneration Technologies; Biomedical Technology Wing; Sree Chitra Tirunal Institute for Medical Sciences and Technology; Thiruvananthapuram, Kerala, India.
authors.forename: Remya
authors.initials: R
authors.lastname: Nirmal
authors.affiliation: Division of Tissue Engineering and Regeneration Technologies; Biomedical Technology Wing; Sree Chitra Tirunal Institute for Medical Sciences and Technology; Thiruvananthapuram, Kerala, India.
authors.forename: Dhanesh
authors.initials: D
authors.lastname: Vaikkath
authors.affiliation: Division of Tissue Engineering and Regeneration Technologies; Biomedical Technology Wing; Sree Chitra Tirunal Institute for Medical Sciences and Technology; Thiruvananthapuram, Kerala, India.
authors.forename: Prabha D
authors.initials: PD
authors.lastname: Nair
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002478:Cells, Cultured; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology; D051379:Mice; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D016062:Porosity; D013057:Spectrum Analysis; D013499:Surface Properties; D013818:Thermogravimetry
chemical_list: D000438:Alcohols; D001672:Biocompatible Materials; D019904:Polymethyl Methacrylate
keywords: bioactive glass; bioactivity; bone regeneration; hydroxyl carbonate apatite; scaffolds; sol gel synthesis; stabilization; tissue engineering