title: The impact of hypoxia on cell death pathways.
abstract: Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial infarction, stroke and ischaemic acute kidney injury. In these diseases, the presence of hypoxia can significantly affect the rate of cell death and thus may make a significant contribution to disease progression. In the present review, we discuss the complex relationship that exists between the presence of hypoxia and the regulation of cell death pathways.
authors.affiliation: School of Medicine and Medical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Colin R
authors.initials: CR
authors.lastname: Lenihan
authors.forename: Cormac T
authors.initials: CT
authors.lastname: Taylor
mesh_terms: D000818:Animals; D016923:Cell Death; D015687:Cell Hypoxia / Q000235:genetics; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D051793:Hypoxia-Inducible Factor 1; D016328:NF-kappa B