title: Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy.
abstract: OBJECTIVE
  To quantitatively evaluate the time course of macular choroidal blood flow velocity in acute central serous chorioretinopathy (CSC).
  
  
  METHODS
  This retrospective observational case series included 21 eyes of 20 patients (17 men, 3 women; mean age, 53.0 years) with treatment-naïve acute CSC. Laser speckle flowgraphy was performed to calculate macular mean blur rate (MBR), an indicator of relative blood flow velocity at the first visit, 3 and 6 months thereafter. Changes in average MBR values were compared with visual improvement at 6 months.
  
  
  RESULTS
  Subretinal fluid completely resolved in all eyes within 6 months, while best-corrected visual acuity (BCVA) significantly improved at 6 months compared to the initial BCVA. During the follow-up period, the average MBR significantly decreased to 92.8% and 82.3% at 3 and 6 months, respectively, against baseline (100%). Importantly, there was a negative correlation between the BCVA recovery and the MBR decrease, showing the possible association of MBR increase with poor visual prognosis. Multiple regression analysis demonstrated no significant correlation between MBR and ocular perfusion pressure.
  
  
  CONCLUSIONS
  These results indicate that macular choroidal blood flow velocity decreases concurrently with regression of CSC, suggesting a validity of choroidal blood flow elevation in the pathogenesis of acute CSC.
authors.affiliation: Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Michiyuki
authors.initials: M
authors.lastname: Saito
authors.forename: Wataru
authors.initials: W
authors.lastname: Saito
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Chikako
authors.initials: C
authors.lastname: Yoshizawa
authors.forename: Akio
authors.initials: A
authors.lastname: Fujiya
authors.forename: Kousuke
authors.initials: K
authors.lastname: Noda
authors.forename: Susumu
authors.initials: S
authors.lastname: Ishida
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D056833:Central Serous Chorioretinopathy / Q000473:pathology / Q000503:physiopathology*; D002829:Choroid / Q000473:pathology / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008266:Macula Lutea / Q000098:blood supply* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012171:Retinal Vessels / Q000503:physiopathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence