title: Lung cancer associated with neurofibromatosis type I.
abstract: Lung cancer associated with neurofibromatosis type I is considered very rare, and only a few case reports have been described in the literature. There is some evidence that a genetic linkage between neurofibromatosis and carcinogenesis in the lung may exist. We present a 42-year-old female, lifetime nonsmoker with a known history of neurofibromatosis type I, free of respiratory symptoms, who underwent a low-dose HRCT of the lungs to investigate any occult interstitial lung changes. A solitary ill-defined nodule of a ground-glass opacity was detected incidentally in the middle lobe with no associated lymphadenopathy or metastatic disease. Several thin-walled lung cysts were also seen in the lower lobes. Histological analysis of the nodule after middle lobectomy revealed well-differentiated adenocarcinoma. The patient did not receive systemic chemotherapy or radiotherapy. She was free of disease on 18-month followup.
authors.affiliation: Department of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Oikonomou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Mikroulis
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Mintzopoulou
authors.forename: Lawal
authors.initials: L
authors.lastname: Lukman
authors.forename: Panos
authors.initials: P
authors.lastname: Prassopoulos