title: Relationship between ceruloplasmin and oxidative biomarkers including ferritin among healthy Japanese.
abstract: Serum ceruloplasmin (CP), a marker relevant to copper metabolism, is one of famous inflammation markers with a reduction in Wilson's disease, whereas serum ferritin is a marker relevant to iron metabolism. Recently, ferritin is pointed out to be related with oxidative stress. However, there is still no population research which showed the relation of CP and ferritin. Therefore, we investigated the relationship between CP and ferritin including oxidative stress biomarkers among healthy Japanese (n = 389). We measured serum CP, ferritin, Fe, high-sensitivity C-reactive protein (hs-CRP), and urinary oxidative stress biomarkers [H2O2, 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-isoprostane] and so on. Subjects showed that age; 41.7 ± 10.0 (year), CP; 31.9 ± 6.8 (mg/dl), ferritin; 123.5 ± 121.0 (ng/ml), hs-CRP; 0.89 ± 2.53 (mg/l), 8-OHdG; 10.2 ± 4.4 [ng/mg creatinine (Cre)] and H2O2; 6.5 ± 10.9 (µM/g Cre), (All data mentioned above were expressed as mean ± SD). CP was significantly and positively correlated with hs-CRP and inversely correlated with ferritin, Fe and 8-OHdG. By a multiple logistic regression analysis, odds ratio of CP according to quartiles of hs-CRP was 4.86, and according to quartiles of 8-OHdG was 0.39 after adjusting for age and other confounding factors. In conclusion, our findings suggest that CP was an antioxidative biomarker which controls oxidative stress, whereas ferritin was a marker which may participate in the generation of oxidative stress.
authors.affiliation: Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan.
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Inoue
authors.forename: Noriko
authors.initials: N
authors.lastname: Sakano
authors.forename: Keiki
authors.initials: K
authors.lastname: Ogino
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Sato
authors.forename: Da-Hong
authors.initials: DH
authors.lastname: Wang
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kubo
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Sakiko
authors.initials: S
authors.lastname: Kanbara
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyatake
keywords: 8-OHdG; ceruloplasmin; ferritin; high-sensitivity C-reactive protein; oxidative stress