title: Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts.
abstract: To distinguish hypertrophic cardiomyopathy (HCM) from hypertensive left ventricular hypertrophy (H-LVH) based on a morphological examination is often challenging. Growth differentiation factor 15 (GDF-15) is a novel diagnostic and prognostic biomarker for several cardiovascular diseases. In patients with LVH, GDF-15 promises to be a useful biomarker to distinguish between HCM and H-LVH. We evaluated 93 patients with H-LVH, 28 with HCM, and 28 disease control individuals. Serum GDF-15 concentrations were measured with an enzyme-linked immunosorbent assay. Circulating GDF-15 levels were significantly higher in patients with H-LVH than with HCM (P = 0.003). On the other hand, values for plasma B-type natriuretic peptide (BNP) levels were significantly lower in patients with H-LVH than with HCM (P = 0.004). Serum GDF-15 and plasma BNP levels positively correlated in patients with H-LVH but not with HCM. Multivariate logistic regression analysis revealed GDF-15 (odds ratio 12.06, confidence interval 1.85-78.77, P < 0.01) as an independent predictor of H-LVH among patients with LVH. In receiver-operating characteristic analysis, GDF-15 achieved an area under the curve of 0.70 for the identification of H-LVH. We found that GDF-15 might be a useful biomarker for discriminating HCM from H-LVH. Understanding serum GDF-15 values may have clinical utility for patients with LVH because the therapeutic strategies for treating HCM and H-LVH differ.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Hanatani
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Izumiya
authors.forename: Seiji
authors.initials: S
authors.lastname: Takashio
authors.forename: Sunao
authors.initials: S
authors.lastname: Kojima
authors.forename: Megumi
authors.initials: M
authors.lastname: Yamamuro
authors.forename: Satoshi
authors.initials: S
authors.lastname: Araki
authors.forename: Taku
authors.initials: T
authors.lastname: Rokutanda
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tsujita
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Yamamoto
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tanaka
authors.forename: Shinji
authors.initials: S
authors.lastname: Tayama
authors.forename: Koichi
authors.initials: K
authors.lastname: Kaikita
authors.forename: Seiji
authors.initials: S
authors.lastname: Hokimoto
authors.forename: Seigo
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000175:diagnosis; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005260:Female; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve
chemical_list: D015415:Biomarkers; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15; D020097:Natriuretic Peptide, Brain