title: Potential of zebrafish for anticancer drug screening.
abstract: BACKGROUND
  The zebrafish is a powerful vertebrate model organism for large scale genetic and chemical screens.
  
  
  OBJECTIVE
  With the rapid development of cancer modeling in zebrafish, great opportunities exist for chemical screens to find anticancer agents.
  
  
  METHODS
  Using embryos, pathway screens can be designed based on our knowledge of cancer biology. Anticancer chemical screens using tumor bearing adult zebrafish facilitate preclinical testing.
  
  
  CONCLUSIONS
  Current developments in improving cancer models and automated imaging technology have the potential of finding novel compounds that disrupt tumor biology.
authors.affiliation: Stem Cell Program and Hematology/Oncology, Children's Hospital Howard Hughes Medical Institute Harvard Medical School, Boston, MA 02115, USA +1 617 919 2069 ; +1 617 730 0222 ; zon@enders.tch.harvard.edu.
authors.forename: Leonard I
authors.initials: LI
authors.lastname: Zon
authors.forename: Xiuning
authors.initials: X
authors.lastname: Le