title: Intermediate-term outcome of single kidney grafts from pediatric donors weighing 10-14 kg in adult recipients.
abstract: BACKGROUND
  Kidneys from pediatric donors weighing <10 kg are preferably transplanted en bloc, while kidneys from donors weighing >15 kg can be safely transplanted as single kidneys. However, single kidney transplantation from donors weighing 10-14 kg is controversial and has not been well investigated.
  
  
  METHODS
  We analyzed the outcome of 15 recipients of single kidneys from donors weighing 10-14 kg (study group) with 40 recipients receiving an allograft from ideal deceased donors (control group).
  
  
  RESULTS
  After a follow-up of three yr, death-censored graft survival was 100% in both groups. The calculated creatinine clearance was lower in the study group at six months (53 vs. 71 mL/min; p = 0.01) and similar at 12 months (68 vs. 68 mL/min; p = 0.48), 24 months (81 vs. 70 mL/min; p = 0.58), and 36 months (74 vs. 69 mL/min; p = 0.59). Urinary albumin/creatinine ratios were comparable between the two groups up to two yr. At three yr, urinary albumin/creatinine ratios were higher in the study group than the control group (10.5 vs. 0.9 mg/mmol; p = 0.007). Surveillance biopsies at three and six months post-transplant revealed no evidence for focal segmental glomerulosclerosis in the study group.
  
  
  CONCLUSIONS
  Transplantation of single pediatric kidneys from donors weighing 10-14 kg into adult recipients provides excellent intermediate-term outcomes. Low-grade albuminuria, three yr post-transplant, might indicate late-onset hyperfiltration injury.
authors.affiliation: Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.
authors.forename: Isabel
authors.initials: I
authors.lastname: Gröschl
authors.forename: Thomas
authors.initials: T
authors.lastname: Wolff
authors.forename: Lorenz
authors.initials: L
authors.lastname: Gürke
authors.forename: Thomas
authors.initials: T
authors.lastname: Eugster
authors.forename: Helmut
authors.initials: H
authors.lastname: Hopfer
authors.forename: Jürg
authors.initials: J
authors.lastname: Steiger
authors.forename: Stefan
authors.initials: S
authors.lastname: Schaub
authors.forename: Felix
authors.initials: F
authors.lastname: Burkhalter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000150:complications / Q000401:mortality / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D055815:Young Adult