title: Notch signaling and bone remodeling.
abstract: Notch signaling plays context-dependent roles in the development and maintenance of many cell types and tissues in mammals. In the skeleton, both osteoblasts and osteoclasts require Notch signaling for proper differentiation and function, and the specific roles of Notch are dependent on the differentiation status of the cell. The recent discovery of activating NOTCH2 mutations as the cause of Hajdu-Cheney syndrome has highlighted the significance of Notch signaling in human bone physiology.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Jenna
authors.initials: J
authors.lastname: Regan
authors.forename: Fanxin
authors.initials: F
authors.lastname: Long
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000235:genetics*; D002454:Cell Differentiation; D004247:DNA / Q000235:genetics*; D004252:DNA Mutational Analysis; D006801:Humans; D009154:Mutation; D010006:Osteoblasts / Q000378:metabolism / Q000473:pathology*; D010010:Osteoclasts / Q000378:metabolism / Q000473:pathology*; D051880:Receptors, Notch / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch; D004247:DNA