title: Validation of the ABCD3-I score to predict stroke risk after transient ischemic attack.
abstract: OBJECTIVE
  The Age, Blood Pressure, Clinical Features, Duration, and Diabetes plus Dual TIA (ABCD(3)-I) score is recommended to predict the risk of early stroke after transient ischemic attack. The aim of this study was to validate the predictive value of the ABCD(3)-I score and compare the accuracy of the Age, Blood Pressure, Clinical Features, Duration, and Diabetes (ABCD(2)) and ABCD(3)-I scores in a Chinese population.
  
  
  METHODS
  Data were prospectively collected from patients who had transient ischemic attack, as defined by the World Health Organization time-based criteria. ABCD(2) and ABCD(3)-I scores were available within 7 days of the index transient ischemic attack. The predictive outcome was stroke occurrence at 90 days. The receiver-operating characteristic curves were plotted, and the C statistics were calculated as a measure of predictive ability. The comparison of the area under the receiver-operating characteristic curve (area under the curve) was performed by Z test.
  
  
  RESULTS
  Among 239 eligible patients, the mean age was 57.4±13.32 years, and 40.2% of the patients were women. The incidence of stroke at 90 days was 12.1%, which ranged from 0% in patients with lower ABCD(3)-I scores (0-3) to 40.91% in those with higher scores of 8 to 13 (P for trend <0.0001). Moreover, the C statistic of ABCD(3)-I scores (0.825; 95% confidence interval, 0.752-0.898) was statistically higher than that of ABCD(2) scores (0.694; 95% confidence interval, 0.601-0.786; P<0.001).
  
  
  CONCLUSIONS
  The ABCD(3)-I score had a higher predictive value than the ABCD(2) score for assessing the risk of early stroke after transient ischemic attack in a Chinese population.
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Jianshe E Rd, Erqi District, Zhengzhou, Henan Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Fang
authors.forename: Lu
authors.initials: L
authors.lastname: Zhao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Song
authors.initials: S
authors.lastname: Tan
authors.forename: Jiameng
authors.initials: J
authors.lastname: Lu
authors.forename: Shilei
authors.initials: S
authors.lastname: Sun
authors.forename: Avinash
authors.initials: A
authors.lastname: Chandra
authors.forename: Ruihao
authors.initials: R
authors.lastname: Wang
authors.forename: Yuming
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D002546:Ischemic Attack, Transient / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012306:Risk; D018570:Risk Assessment; D012720:Severity of Illness Index; D020521:Stroke / Q000453:epidemiology / Q000209:etiology*; D013997:Time Factors