title: Heparin-induced thrombocytopenia leading to stroke, lower extremity arterial occlusive disease, and skin necrosis: a case report.
abstract: Enoxaparin sodium is a low molecular weight heparin (LMWH) used to treat and prevent deep venous thrombosis (DVT). The common complications related to the use of heparin are bleeding, allergic reaction, and osteoporosis. A less common complications are thrombocytopenia and thromboembolism that may not be generally recognized. We present a case of low molecular weight (LMW) heparin-induced thrombocytopenia (HIT) causing stroke, lower extremity arterial occlusion, and skin necrosis. Monitoring the platelet count is essential for early diagnosis of HIT. All patients who undergo heparinization should have a baseline platelet count done before the regimen is started and should be monitored closely especially during the first weeks of treatment.
authors.affiliation: Department of Neurology, Faculty of Medicine, Gazi University , Ankara , Turkey and.
authors.forename: B
authors.initials: B
authors.lastname: Nazliel
authors.forename: H Z
authors.initials: HZ
authors.lastname: Batur Caglayan
authors.forename: I
authors.initials: I
authors.lastname: Yildirim Capraz
authors.forename: C
authors.initials: C
authors.lastname: Irkec
authors.forename: M
authors.initials: M
authors.lastname: Yagci
authors.forename: T
authors.initials: T
authors.lastname: Gesoglu
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000209:etiology* / Q000601:surgery; D017128:Embolectomy; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D020521:Stroke / Q000175:diagnosis / Q000209:etiology*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D006495:Heparin, Low-Molecular-Weight; D006493:Heparin