title: Imaging of chronic inflammatory bowel disease with 18F-FDG PET in children and adolescents.
abstract: Standard for diagnosis of inflammatory bowel disease (IBD) is the endoscopy of the stomach and the intestine. Aim of this study was to determine the value of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in pediatric patients with mild to moderate IBD.We included 23 children and adolescents between 8 and 17 years (median 15 years, 13 boys, 10 girls) in this retrospective study in a routine clinical setting. Diagnoses were Crohn's disease in 19 and ulcerative colitis in 4 cases.3 children had a conventional FDG-PET, 20 patients a combined FDG-PET-computed tomography exam. All children had upper and lower intestinal endoscopy with biopsy and a Hydro-MRI exam to assess the jejunum and proximal ileum. The gastrointestinal tract was divided in 7 segments: Stomach plus duodenum, jejunum and proximal ileum, terminal ileum, cecum plus ascending colon, transverse colon, descending colon, and rectosigmoid.Superficial gastric lesions were missed, gastric ulcerations were detected. For the stomach, the sensitivity was 0.25, the specificity was 1.00, the positive predictive value was 1.00, for the lower intestine (terminal ileum and colon) the values were 0.74, 0.88, and 0.96; for the terminal ileum 0.89, 0.75 and 0.94, respectively.The sensitivity and specificity for of ileal and colonic lesions is high. FDG-PET has to be discussed as a tool for the determination of extent and degree of inflammation, especially in those parts of the small bowel that are not accessible to endoscopy. This has to be weighed against the additional radiation exposure administrated.
authors.affiliation: Diagnostische und Interventionelle Radiologie, Medizinische Hochschule Hannover, Deutschland. berthold.daniel@mh-hannover.de
authors.forename: L D
authors.initials: LD
authors.lastname: Berthold
authors.forename: D
authors.initials: D
authors.lastname: Steiner
authors.forename: D
authors.initials: D
authors.lastname: Scholz
authors.forename: G
authors.initials: G
authors.lastname: Alzen
authors.forename: K-P
authors.initials: KP
authors.lastname: Zimmer
mesh_terms: D000293:Adolescent; D002648:Child; D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging*; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement; D007422:Intestines / Q000000981:diagnostic imaging; D008297:Male; D049268:Positron-Emission Tomography; D012680:Sensitivity and Specificity; D013270:Stomach; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18