title: Relationship between corneal hysteresis and optic nerve parameters measured with spectral domain optical coherence tomography.
abstract: BACKGROUND
  Corneal hysteresis (CH) has been associated with visual field damage in glaucoma and is related to the velocity of perimetric glaucoma progression. We undertook this investigation to determine whether CH is associated with structural markers of glaucoma damage on spectral domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  In this retrospective study, 131 patients under glaucoma evaluation were evaluated with SD-OCT (Cirrus; Carl Zeiss Meditec, Dublin, CA) and had CH measurements with the ocular response analyzer (Reichert, Inc., Buffalo, NY). Pearson and partial correlation adjusting for age were preformed to examine the association between CH and variables of interest. Generalized estimating equations were used to construct simple and multiple linear models.
  
  
  RESULTS
  While Pearson correlations were modest overall, CH best correlated with mean deviation (MD; r = 0.19) followed by average retinal nerve fiber layer (RNFL) thickness (r = 0.18) and vertical cup to disc ratio (r = -0.11) in the open angle glaucoma group. In univariable models, CH varied as a function of MD (ß = 0.1, 95 % CI 0.03, 0.1; p < 0.001) and of average RNFL thickness (ß = 0.2, 95 % CI 0.1, 0.4; p = 0.001). In a multivariable analysis including MD, age, average RNFL thickness, and glaucoma status, MD (p = 0.001) and age (p < 0.001) retained significant associations with CH.
  
  
  CONCLUSIONS
  In patients under evaluation and treatment for glaucoma, CH was more closely related to visual field MD than to structural markers of glaucoma damage as measured by SD-OCT.
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, 11th Floor, New York, NY 10021, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Vu
authors.forename: Fabiana Q
authors.initials: FQ
authors.lastname: Silva
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Haseltine
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Ehrlich
authors.forename: Nathan M
authors.initials: NM
authors.lastname: Radcliffe
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D003315:Cornea / Q000502:physiology*; D063171:Corneal Pachymetry; D003430:Cross-Sectional Studies; D004548:Elasticity / Q000502:physiology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000188:drug therapy / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014794:Visual Fields / Q000502:physiology
chemical_list: D000959:Antihypertensive Agents