title: Circulating levels of tissue factor microparticle procoagulant activity are reduced with antiretroviral therapy and are associated with persistent inflammation and coagulation activation among HIV-positive patients.
abstract: Activation of coagulation pathways may contribute to risk for non-AIDS-related conditions among HIV-positive patients. Tissue factor (TF)-dependent procoagulant activity on circulating microparticles (MP-TF) in the plasma of 163 HIV-positive participants, both untreated and treated, with viral suppression was measured. MP-TF activity was 39% lower among treated versus untreated participants (P < 0.001), which persisted in adjusted models (-36%, P = 0.03). Among treated participants, MP-TF activity correlated modestly with D-dimer (r = 0.24, P = 0.01), von Willebrand factor (r = 0.36, P < 0.001), and interleukin-6 (r = 0.20, P = 0.04) levels. Future research should focus on mechanisms driving residual functional TF activity and whether these alterations have clinical consequences for non-AIDS-defining complications.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, MN, USA. baker459@umn.edu
authors.forename: Jason V
authors.initials: JV
authors.lastname: Baker
authors.forename: Katherine
authors.initials: K
authors.lastname: Huppler Hullsiek
authors.forename: Robert L
authors.initials: RL
authors.lastname: Bradford
authors.forename: Rachel
authors.initials: R
authors.lastname: Prosser
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Key
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D002097:C-Reactive Protein / Q000032:analysis; D055252:Cell-Derived Microparticles; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D013925:Thromboplastin / Q000032:analysis / Q000378:metabolism*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D019380:Anti-HIV Agents; D015850:Interleukin-6; D014841:von Willebrand Factor; D002097:C-Reactive Protein; D013925:Thromboplastin