title: Total synthesis of pyoverdin D.
abstract: Pyoverdin D is an important siderophore that is used by the human pathogen Pseudomonas aeruginosa to import iron and gain a competitive advantage. This unique partially cyclic octapeptide bears four nonproteinogenic amino acids, including (δ)N-formyl-(δ)N-hydroxy-l-ornithine, and a catechol containing chiral chromophore. Here, we report the first total synthesis of pyoverdin D.
authors.affiliation: Department of Chemistry and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel.
authors.forename: Roi
authors.initials: R
authors.lastname: Mashiach
authors.forename: Michael M
authors.initials: MM
authors.lastname: Meijler
mesh_terms: D006801:Humans; D007501:Iron / Q000378:metabolism; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D017262:Siderophores / Q000737:chemistry / Q000378:metabolism
chemical_list: D009842:Oligopeptides; D017262:Siderophores; C042453:pyoverdin; D007501:Iron