title: DNA gridiron nanostructures based on four-arm junctions.
abstract: Engineering wireframe architectures and scaffolds of increasing complexity is one of the important challenges in nanotechnology. We present a design strategy to create gridiron-like DNA structures. A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons were assembled, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects.
authors.affiliation: The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA. dongran.han@asu.edu
authors.forename: Dongran
authors.initials: D
authors.lastname: Han
authors.forename: Suchetan
authors.initials: S
authors.lastname: Pal
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Shuoxing
authors.initials: S
authors.lastname: Jiang
authors.forename: Jeanette
authors.initials: J
authors.lastname: Nangreave
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure*; D008958:Models, Molecular; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA