title: Seroprevalence of mumps in The Netherlands: dynamics over a decade with high vaccination coverage and recent outbreaks.
abstract: Here we present mumps virus specific antibody levels in a large cross-sectional population-based serosurveillance study performed in the Netherlands in 2006/2007 (n = 7900). Results were compared with a similar study (1995/1996) and discussed in the light of recent outbreaks. Mumps antibodies were tested using a fluorescent bead-based multiplex immunoassay. Overall seroprevalence was 90.9% with higher levels in the naturally infected cohorts compared with vaccinated cohorts. Mumps virus vaccinations at 14 months and 9 years resulted in an increased seroprevalence and antibody concentration. The second vaccination seemed to be important in acquiring stable mumps antibody levels in the long term. In conclusion, the Dutch population is well protected against mumps virus infection. However, we identified specific age- and population groups at increased risk of mumps infection. Indeed, in 2007/2008 an outbreak has occurred in the low vaccination coverage groups emphasizing the predictive value of serosurveillance studies.
authors.affiliation: Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands. Gaby.Smits@rivm.nl
authors.forename: Gaby
authors.initials: G
authors.lastname: Smits
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Mollema
authors.forename: Susan
authors.initials: S
authors.lastname: Hahné
authors.forename: Hester
authors.initials: H
authors.lastname: de Melker
authors.forename: Irina
authors.initials: I
authors.lastname: Tcherniaeva
authors.forename: Sandra
authors.initials: S
authors.lastname: Waaijenborg
authors.forename: Rob
authors.initials: R
authors.lastname: van Binnendijk
authors.forename: Fiona
authors.initials: F
authors.lastname: van der Klis
authors.forename: Guy
authors.initials: G
authors.lastname: Berbers
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009107:Mumps / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control*; D009108:Mumps Vaccine / Q000008:administration & dosage*; D009426:Netherlands / Q000453:epidemiology; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D009108:Mumps Vaccine