title: Two novel saponins of 20, 26-epoxy derivatives of pseudojujubogenin from the seeds of Hovenia trichocarpa.
abstract: Two new saponins of 20, 26-epoxy derivatives of pseudojujubogenin, hoduloside XI (1) and hoduloside XII (2) were isolated from the seeds of Hovenia trichocarpa. The structures of the new compounds were established by extensive NMR experiments and chemical methods. Hoduloside XI was confirmed to be 3-O-{β-D-glucopyranosyl(1→3)-[β-D-xylopyranosyl(1→2)]-α-L-arabinopyranosyl}-20, 26-epoxypseudojujubogenin. Hoduloside XII was identified as 3-O-{β-D-xylopyranose(1→2)glucopyranosyl(1→3)[rhamnopyranose(1→2)]β-D-glucopyranosyl}-20, 26-epoxypseudojujubogenin. The in vitro cytotoxic activity of compounds 1 and 2 was assayed. They displayed inhibitive activities against human cancer cell lines HL60 and K562.
authors.affiliation: Zhejiang Food and Drug Administration, Hangzhou 310012, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jianke
authors.initials: J
authors.lastname: Yang
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Li
authors.forename: Weiguo
authors.initials: W
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D027823:Rhamnaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D012639:Seeds / Q000737:chemistry; D014315:Triterpenes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C585633:hoduloside XI; C585634:hoduloside XII; C400159:jujubogenin