title: [Effect of topical application of a recombinant adenovirus carrying promyelocytic leukemia gene in a psoriasis-like mouse model].
abstract: OBJECTIVE
  To investigate the effects of topical treatment with adenovirus-mediated promyelocytic leukemia gene (PML) gene in a psoriasis-like mouse model.
  
  
  METHODS
  The effect of adenovirus-mediated PML gene on the granular layer of mouse tail scale epidermis and epithelial mitosis were observed on longitudinal histological sections prepared from the tail skin and vaginal epithelium of the mice.
  
  
  RESULTS
  Adenovirus-mediated PML gene significantly inhibited mitosis of mouse vaginal epithelial cells and promoted the formation of granular layer in mouse tail scale epidermis.
  
  
  CONCLUSIONS
  The therapeutic effect of PML gene in the psoriasis-like mouse model may be associated with increased granular cells and suppressed epidemic cell proliferation.
authors.affiliation: Department of Dermatology, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China. wqy0811@163.com
authors.forename: Qiongyu
authors.initials: Q
authors.lastname: Wang
authors.forename: Aijun
authors.initials: A
authors.lastname: Zhang
authors.forename: Huiqun
authors.initials: H
authors.lastname: Ma
authors.forename: Shijie
authors.initials: S
authors.lastname: Wang
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Ma
authors.forename: Xingwei
authors.initials: X
authors.lastname: Zou
authors.forename: Ruilian
authors.initials: R
authors.lastname: Li
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000287:Administration, Topical; D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000166:cytology*; D005260:Female; D005822:Genetic Vectors; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008938:Mitosis; D009687:Nuclear Proteins / Q000235:genetics*; D000071156:Promyelocytic Leukemia Protein; D011565:Psoriasis / Q000628:therapy*; D012867:Skin / Q000166:cytology; D014157:Transcription Factors / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D014621:Vagina / Q000166:cytology
chemical_list: D009687:Nuclear Proteins; C513293:Pml protein, mouse; D000071156:Promyelocytic Leukemia Protein; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins