title: Surface modification of iron oxide nanoparticles by biocompatible polymers for tissue imaging and targeting.
abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) are excellent MR contrast agents when coated with biocompatible polymers such as hydrophilic synthetic polymers, proteins, polysaccharides, and lipids, which improve their stability and biocompatibility and reduce their aggregation. Various biocompatible materials, coated or conjugated with targeting moieties such as galactose, mannose, folic acid, antibodies and RGD, have been applied to SPION surfaces to provide tissue specificity to hepatocytes, macrophages, and tumor regions in order to reduce non-specific uptake and improve biocompatibility. This review discusses the recent progress in the development of biocompatible and hydrophilic polymers for improving stability of SPIONs and describes the carbohydrates based biocompatible materials that are providing SPIONs with cell/tissue specificity as ligands.
authors.affiliation: Department of Biomedical Sciences and Center for Biomedical Human Resources (BK-21 project), Chonnam National University Medical School, Gwangju 501-757, South Korea; Clinical Vaccine R&D Center, Chonnam National University Hwasun Hospital, Jeonnam 519-763, South Korea.
authors.forename: Muthunarayanan
authors.initials: M
authors.lastname: Muthiah
authors.forename: In-Kyu
authors.initials: IK
authors.lastname: Park
authors.forename: Chong-Su
authors.initials: CS
authors.lastname: Cho
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002460:Cell Line; D006801:Humans; D058185:Magnetite Nanoparticles; D051379:Mice; D057054:Molecular Imaging; D011108:Polymers; D013499:Surface Properties; D051598:Whole Body Imaging
chemical_list: D001672:Biocompatible Materials; D058185:Magnetite Nanoparticles; D011108:Polymers
keywords: Biocompatible polymer; Iron oxide nanoparticles; Surface modification; Targeting; Tissue imaging