title: Nano-graphene oxide: a potential multifunctional platform for cancer therapy.
abstract: Nano-GO is a graphene derivative with a 2D atomic layer of sp² bonded carbon atoms in hexagonal conformation together with sp³ domains with carbon atoms linked to oxygen functional groups. The supremacy of nano-GO resides essentially in its own intrinsic chemical and physical structure, which confers an extraordinary chemical versatility, high aspect ratio and unusual physical properties. The chemical versatility of nano-GO arises from the oxygen functional groups on the carbon structure that make possible its relatively easy functionalization, under mild conditions, with organic molecules or biological structures in covalent or non-covalent linkage. The synergistic effects resulting from the assembly of well-defined structures at nano-GO surface, in addition to its intrinsic optical, mechanical and electronic properties, allow the development of new multifunctional hybrid materials with a high potential in multimodal cancer therapy. Herein, a comprehensive review of the fundamental properties of nano-GO requirements for cancer therapy and the first developments of nano-GO as a platform for this purpose is presented.
authors.affiliation: TEMA-NRD, Mechanical Engineering Department and Aveiro Institute of Nanotechnology (AIN), University of Aveiro, 3810-193 Aveiro, Portugal. ggoncalves@ua.pt.
authors.forename: Gil
authors.initials: G
authors.lastname: Gonçalves
authors.forename: Mercedes
authors.initials: M
authors.lastname: Vila
authors.forename: María-Teresa
authors.initials: MT
authors.lastname: Portolés
authors.forename: María
authors.initials: M
authors.lastname: Vallet-Regi
authors.forename: José
authors.initials: J
authors.lastname: Gracio
authors.forename: Paula Alexandrina A P
authors.initials: PA
authors.lastname: Marques
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D056831:Coordination Complexes / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D006108:Graphite / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D010087:Oxides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011859:Radiography
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D004337:Drug Carriers; D008081:Liposomes; D010087:Oxides; D011092:Polyethylene Glycols; D006108:Graphite
keywords: cancer therapy; graphene; graphene oxide; nanoplatforms; theranostic