title: A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century.
abstract: This article describes our experiences in creating a fully integrated, globally accessible, automated chemical synthesis laboratory. The goal of the project was to establish a fully integrated automated synthesis solution that was initially focused on minimizing the burden of repetitive, routine, rules-based operations that characterize more established chemistry workflows. The architecture was crafted to allow for the expansion of synthetic capabilities while also providing for a flexible interface that permits the synthesis objective to be introduced and manipulated as needed under the judicious direction of a remote user in real-time. This innovative central synthesis suite is herein described along with some case studies to illustrate the impact such a system is having in expanding drug discovery capabilities.
authors.affiliation: Discovery Chemistry & Research Technologies, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, IN 46158, USA. godfrey_alex_g@lilly.com
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Godfrey
authors.forename: Thierry
authors.initials: T
authors.lastname: Masquelin
authors.forename: Horst
authors.initials: H
authors.lastname: Hemmerle
mesh_terms: D057205:Automation, Laboratory; D004209:Disposable Equipment; D055808:Drug Discovery / Q000379:methods / Q000458:organization & administration* / Q000592:standards; D017598:Efficiency, Organizational; D005160:Facility Design and Construction / Q000592:standards; D007753:Laboratories / Q000458:organization & administration* / Q000592:standards; D009936:Organizational Innovation; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000592:standards; D012371:Robotics / Q000458:organization & administration* / Q000592:standards; D012985:Software Design; D013678:Technology, Pharmaceutical / Q000379:methods / Q000458:organization & administration* / Q000592:standards; D014584:User-Computer Interface; D057188:Workflow
chemical_list: D004364:Pharmaceutical Preparations