title: Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.
abstract: Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.
authors.affiliation: University of Vienna, Institute of Inorganic Chemistry, Währinger Str. 42, 1090 Vienna, Austria. wolfgang.kandioller@univie.ac.at
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kandioller
authors.forename: Evelyn
authors.initials: E
authors.lastname: Balsano
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Meier
authors.forename: Ute
authors.initials: U
authors.lastname: Jungwirth
authors.forename: Simone
authors.initials: S
authors.lastname: Göschl
authors.forename: Alexander
authors.initials: A
authors.lastname: Roller
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jakupec
authors.forename: Walter
authors.initials: W
authors.lastname: Berger
authors.forename: Bernhard K
authors.initials: BK
authors.lastname: Keppler
authors.forename: Christian G
authors.initials: CG
authors.lastname: Hartinger
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D006147:Guanine / Q000031:analogs & derivatives / Q000737:chemistry; D006801:Humans; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D009992:Osmium / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012238:Rhodium / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000972:Antineoplastic Agents, Phytogenic; D056831:Coordination Complexes; D009285:Naphthoquinones; D017382:Reactive Oxygen Species; D009992:Osmium; D006147:Guanine; D012428:Ruthenium; C014542:9-ethylguanine; C008252:lapachol; D012238:Rhodium