title: A silver complex of N,N'-disubstituted cyclic thiourea as an anti-inflammatory inhibitor of IκB kinase.
abstract: A silver complex of N,N'-disubstituted cyclic thiourea inhibits inflammatory cytokine-stimulated NF-κB activity via IκB kinase inactivation.
authors.affiliation: Department of Chemistry, State Key Laboratory of Synthetic Chemistry, HKU Shenzhen Institute of Research and Innovation, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Iris Wing-Shan
authors.initials: IW
authors.lastname: Lin
authors.forename: Chun-Nam
authors.initials: CN
authors.lastname: Lok
authors.forename: Kun
authors.initials: K
authors.lastname: Yan
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors*; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000737:chemistry; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013890:Thiourea / Q000737:chemistry / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D047428:Protein Kinase Inhibitors; D014409:Tumor Necrosis Factor-alpha; D012834:Silver; D051550:I-kappa B Kinase; D013890:Thiourea