title: Protective effect of Coleus aromaticus Benth (Lamiaceae) against naphthalene-induced hepatotoxicity.
abstract: OBJECTIVE
  To investigate protective effect of Coleus aromaticus leaf extract against naphthalene induced hepatotoxicity in rats.
  
  
  METHODS
  Eighteen male rats were divided into three groups. Group I rats were treated as control. Group II rats were intraperitoneally administered with naphthalene (435 mg/kg b.wt) dissolved in corn oil once a day for a period of 30 days. Group III rats were treated with leaf extract (100 mg/kg b.wt) dissolved in 0.9% saline and naphthalene (435 mg/kg b.wt) dissolved in corn oil once a day for a period of 30 days.
  
  
  RESULTS
  Significant protective effect was observed against naphthalene induced liver damage, which appeared evident from the response levels of marker enzymes (aspartate transaminase, alanine transaminase, acid phosphatase, alkaline phosphatase and lactate dehydrogenase). The biochemical components viz. triglycerides, free fatty acids, cholesterol acyl transferase, high-density lipoprotein, low-density lipoprotein, cholesterol and bilirubin were found to be increased in liver and serum of naphthalene stressed rats when compared to control.
  
  
  CONCLUSIONS
  Treatment of naphthalene intoxicated rats with plant extract reversed these distorted parameters to near normal levels. Liver histology showed supportive evidence regarding the protective nature of plant extract against fatty changes induced by naphthalene. The present study provides a scientific rationale for using C. aromaticus in the management of liver disorders.
authors.affiliation: Department of Biological Sciences, 5047 Gullen Mall, Wayne State University, Detroit-48202, MI, USA. rbashokkumar@yahoo.com
authors.forename: K
authors.initials: K
authors.lastname: Vijayavel
authors.forename: C
authors.initials: C
authors.lastname: Anbuselvam
authors.forename: B
authors.initials: B
authors.lastname: Ashokkumar
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D031330:Coleus / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers / Q000032:analysis; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D009281:Naphthalenes / Q000633:toxicity*; D010636:Phenols / Q000032:analysis; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016166:Free Radical Scavengers; D009281:Naphthalenes; D010636:Phenols; D010936:Plant Extracts; C031721:naphthalene
keywords: Coleus aromaticu; Hepatoprotection; Hepatotoxicity; Histopathology; Naphthalene