title: Tu-be or not tu-be: that is the question… about serous ovarian carcinogenesis.
abstract: Our understanding of the early natural history of epithelial ovarian carcinoma is limited by the access to early lesions as the disease is very often diagnosed at advanced stages. The incessant ovulation theory from the last century that indicated the ovary as the site for the initiation of high-grade serous cancers is contrary to the newly emerging idea that ovarian cancer could arise from the distal fallopian tube. In view of the recent pathological and molecular studies, we propose to discuss the genesis of high-grade serous ovarian cancer.
authors.affiliation: Department of Histopathology, Centre Jean Perrin, Clermont-Ferrand, France; Department of Surgery, Centre Jean Perrin, Clermont-Ferrand, France; Department of Obstetrics and Gynecology, CHU St Etienne, France. Electronic address: chenegautier@yahoo.fr.
authors.forename: G
authors.initials: G
authors.lastname: Chene
authors.forename: J
authors.initials: J
authors.lastname: Dauplat
authors.forename: N
authors.initials: N
authors.lastname: Radosevic-Robin
authors.forename: A
authors.initials: A
authors.lastname: Cayre
authors.forename: F
authors.initials: F
authors.lastname: Penault-Llorca
mesh_terms: D002278:Carcinoma in Situ; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D018293:Cystadenoma, Serous / Q000209:etiology* / Q000473:pathology*; D005185:Fallopian Tube Neoplasms / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000473:pathology*; D011230:Precancerous Conditions
keywords: Fallopian tube; Ovarian cancer; Ovarian carcinogenesis; Ovarian dysplasia; STIC; Serous tubal intraepithelial carcinoma