title: Cefotaximase and AmpC-producing Shigella flexneri in case of dysentery from southern India.
abstract: Diarrhoea and dysentery caused by Shigella spp. are major public health concerns. Emerging multidrug resistance (MDR) in this pathogen further complicates this disease. Extended spectrum β-lactamases (ESBLs) have been described in this pathogen, which significantly compromises the treatment options for shigellosis. The usual ESBLs seen are sulfhydryl variable (SHV)-type; cefotaximases (CTX-M) are very uncommonly detected. Here, we report a CTX-M type and AmpC-producing Shigella flexneri from a three-year-old boy residing in Central Kerala, South India.
authors.affiliation: Department of Microbiology, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala, India.
authors.forename: S
authors.initials: S
authors.lastname: Oommen
authors.forename: P M Sivan
authors.initials: PM
authors.lastname: Pillai
authors.forename: S
authors.initials: S
authors.lastname: Sushamabai
authors.forename: P Jose
authors.initials: PJ
authors.lastname: Paul
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism*; D002675:Child, Preschool; D004405:Dysentery, Bacillary / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D006801:Humans; D007194:India; D008297:Male; D008826:Microbial Sensitivity Tests; D012763:Shigella flexneri / Q000201:enzymology* / Q000302:isolation & purification; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C071167:beta-lactamase CTX-2; C048795:AmpC beta-lactamases; D001618:beta-Lactamases