title: Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis.
abstract: Nitazoxanide (NTZ) has bactericidal activity against the H37Rv laboratory strain of Mycobacterium tuberculosis with a MIC of 16 μg/ml. However, its efficacy against clinical isolates of M. tuberculosis has not been determined. We found that NTZ's MIC against 50 clinical isolates ranged from 12 to 28 μg/ml with a median of 16 μg/ml and was unaffected by resistance to first- or second-line antituberculosis drugs or a diversity of spoligotypes.
authors.affiliation: Center for Global Health, Department of Medicine, Weill Cornell Medical College, New York, New York, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Shigyo
authors.forename: Oksana
authors.initials: O
authors.lastname: Ocheretina
authors.forename: Yves Mary
authors.initials: YM
authors.lastname: Merveille
authors.forename: Warren D
authors.initials: WD
authors.lastname: Johnson
authors.forename: Jean William
authors.initials: JW
authors.lastname: Pape
authors.forename: Carl F
authors.initials: CF
authors.lastname: Nathan
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Fitzgerald
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000592:standards*; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D009574:Nitro Compounds; D013183:Sputum / Q000382:microbiology; D013844:Thiazoles / Q000494:pharmacology*; D014397:Tuberculosis, Pulmonary / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D009574:Nitro Compounds; D013844:Thiazoles; C041747:nitazoxanide; D007538:Isoniazid