title: Single-trial linear correlation analysis: application to characterization of stimulus modality effects.
abstract: A key objective in systems and cognitive neuroscience is to establish associations between behavioral measures and concurrent neuronal activity. Single-trial analysis has been proposed as a novel method for characterizing such correlates by first extracting neural components that maximally discriminate trials on a categorical variable, (e.g., hard vs. easy, correct vs. incorrect etc.), and then correlate those components to a continues dependent variable of interest, e.g., reaction time, difficulty Index, etc. However, often times in experiment design it is difficult to either define meaningful categorical variables, or to record enough trials for the method to extract the discriminant components. Experiments designed for the study of the effects of stimulus presentation modality in working memory provide such a scenario, as will be exemplified. In this paper, we proposed a new approach to single-trial analysis in which we directly extract neural activity that maximally correlates to single-trial manual response times; eliminating the need to define an arbitrary categorical variable. We demonstrate our method on real electroencephalography (EEG) data recordings from the study of stimulus presentation modality effect (SPME).
authors.affiliation: Center for Applied Neuroscience, University of Cyprus Nicosia, Cyprus ; Research and Development Division, R.K.I Leaders Ltd. Larnaca, Cyprus.
authors.forename: Christoforos
authors.initials: C
authors.lastname: Christoforou
authors.forename: Fofi
authors.initials: F
authors.lastname: Constantinidou
authors.forename: Panayiota
authors.initials: P
authors.lastname: Shoshilou
authors.forename: Panagiotis G
authors.initials: PG
authors.lastname: Simos
keywords: EEG; correlated components; machine learning; neuroimaging; single-trial analysis