title: Cell length sensing for neuronal growth control.
abstract: Neurons exhibit great size differences, and must coordinate biosynthesis rates in cell bodies with the growth needs of different lengths of axons. Classically, axon growth has been viewed mainly as a consequence of extrinsic influences. However, recent publications have proposed at least two different intrinsic axon growth-control mechanisms. We suggest that these mechanisms form part of a continuum of axon growth-control mechanisms, wherein initial growth rates are pre-programmed by transcription factor levels, and subsequent elongating growth is dependent on feedback from intrinsic length-sensing enabled by bidirectional motor-dependent oscillating signals. This model might explain intrinsic limits on elongating neuronal growth and provides a mechanistic framework for determining the connections between genome expression and cellular growth rates in neurons.
authors.affiliation: Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel.
authors.forename: Christin A
authors.initials: CA
authors.lastname: Albus
authors.forename: Ida
authors.initials: I
authors.lastname: Rishal
authors.forename: Mike
authors.initials: M
authors.lastname: Fainzilber
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D049109:Cell Proliferation; D048429:Cell Size; D050677:Core Binding Factor Alpha 3 Subunit / Q000502:physiology; D004398:Dyneins / Q000502:physiology; D006801:Humans; D016547:Kinesins / Q000502:physiology; D008959:Models, Neurological; D016501:Neurites / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D050677:Core Binding Factor Alpha 3 Subunit; D004398:Dyneins; D016547:Kinesins