title: Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.
abstract: In this paper structural and microbiological studies on the ionophorous antibiotic monensin A and its derivatives have been collected. Monensin A is an ionophore which selectively complexes and transports sodium cation across lipid membranes, and therefore it shows a variety of biological properties. This antibiotic is commonly used as coccidiostat and nonhormonal growth promoter. The paper focuses on both the latest and earlier achievements concerning monensin A antimicrobial activity. The activities of monensin derivatives, including modifications of hydroxyl groups and carboxyl group, are also presented.
authors.affiliation: Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland. daniel.lowicki@uj.edu.pl
authors.forename: Daniel
authors.initials: D
authors.lastname: Aowicki
authors.forename: Adam
authors.initials: A
authors.lastname: Huczyński
mesh_terms: D000577:Amides / Q000737:chemistry; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002412:Cations; D003049:Coccidiostats / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D015195:Drug Design; D007476:Ionophores / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D008985:Monensin / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000890:Anti-Infective Agents; D002412:Cations; D003049:Coccidiostats; D007476:Ionophores; D008985:Monensin