title: Eliminating canine rabies, the principal source of human infection: what will it take?
abstract: More than 50,000 people die of rabies each year; most are children in developing countries, and almost all have been bitten by dogs. Eliminating canine rabies throughout the world would save thousands of lives and would reduce the economic impact of the disease by dramatically reducing the requirement for postexposure prophylaxis (PEP). Lengthy experience in the industrialized countries and ongoing programs in Latin America, Africa, and Asia have shown that the elimination of rabies in dogs is an achievable goal. The presence of canine rabies in developing countries is associated with poverty, and most deaths occur in the lowest socioeconomic sectors. To be successful, national rabies control programs should share responsibility with local communities for prevention and control activities and maintaining disease-free status. Legislation should be adapted to local conditions and the realities of dog ownership. While the provision of PEP to all bite victims is affordable in many countries, it is usually beyond the capacity of impoverished nations, which deal with many other health priorities. Ministries of health should provide PEP, either free or with a charge preferably at a subsidized price, replacing the current system in many countries, in which biologics are sold by government-owned and private clinics at a cost beyond the means of bite victims. The public health sector should assume responsibility when animal control strategies are not effectively implemented or when PEP is not administered correctly or is not available. A global strategy is needed to identify gaps in surveillance and diagnosis, improve access to PEP and enhance canine immunization and population management. Such approaches based on a "One Health" model should be coordinated across regions, and should extend control efforts to other dog-related zoonoses. This article introduces a symposium in Antiviral Research on the elimination of canine rabies.
authors.affiliation: Neglected Zoonotic Diseases, Department of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland. meslinf@who.int
authors.forename: F-X
authors.initials: FX
authors.lastname: Meslin
authors.forename: D J
authors.initials: DJ
authors.lastname: Briggs
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000517:prevention & control / Q000821:virology*; D004285:Dogs; D006801:Humans; D011634:Public Health; D011818:Rabies / Q000517:prevention & control* / Q000635:transmission / Q000662:veterinary* / Q000821:virology; D011820:Rabies virus / Q000502:physiology; D015047:Zoonoses / Q000635:transmission / Q000821:virology*