title: Acquisition of carbapenem resistance in multiresistant Klebsiella pneumoniae isolates of sequence type 11 at a university hospital in China.
abstract: Four closely related KPC-producing Klebsiella pneumoniae strains, which were isolated from the patients with neonatal sepsis, harbored bla(CTX-M-14), bla(TEM-1), bla(CTX-M-15), bla(SHV-11),bla(SHV-12), class 1 integron, qnrS1, acc(6')-Ib-cr, and rmtB genes. Multilocus sequence typing experiments showed that all isolates but Kp122 were proven to share the same sequence type (ST), ST11. These isolates have not yet been previously reported in a university-affiliated children's hospital or in the city of Wenzhou.
authors.affiliation: Department of Bacteriology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong wai zheng jie No. 17, Nanchang, 330006, PR China. ly13767160474@sina.com
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Li
authors.forename: La-Gen
authors.initials: LG
authors.lastname: Wan
authors.forename: Wei-Yan
authors.initials: WY
authors.lastname: Jiang
authors.forename: Jing-Hong
authors.initials: JH
authors.lastname: Yang
authors.forename: Fang-Qu
authors.initials: FQ
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology*; D002681:China; D004269:DNA, Bacterial / Q000302:isolation & purification; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D022761:Gene Transfer, Horizontal; D005798:Genes, Bacterial; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D032023:Integrons; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D058885:Multilocus Sequence Typing; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000302:isolation & purification; D018805:Sepsis / Q000382:microbiology / Q000473:pathology; D017422:Sequence Analysis, DNA
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S