title: Corneal thickness measured by Scheimpflug imaging in children with Down syndrome.
abstract: OBJECTIVE
  To measure corneal thickness via the use of a Scheimpflug imaging system (OCULUS Optikgeräte GmbH, Wetzlar, Germany) in children with Down syndrome.
  
  
  METHODS
  This prospective, nonrandomized, clinical trial included children with Down syndrome and age- and sex-matched healthy controls. All subjects received a complete ophthalmologic examination. Corneal topography measurements were acquired by means of Scheimpflug imaging. Central corneal thickness (CCT), thinnest point of cornea (TP), and corneal volume (CV) were analyzed.
  
  
  RESULTS
  A total of 27 children with Down syndrome and 37 control subjects were included in the study. In children with Down syndrome, the mean CCT was 494.27 ± 47 μm, the mean TP was 487 ± 49 μm, and the mean CV was 56.2 ± 6. In the controls, the mean CCT was 539.3 ± 40 μm, the mean TP was 538.0 ± 40.8 μm, and the mean CV was 61.3 ± 4. For all 3 parameters, the difference was statistically significant (P < 0.001). In the Down syndrome group, the CCT was <500 μm in 16 subjects (59.2%) and <450 μm in 5 (18.5%). In the control group, the CCT was <500 μm in 14 subjects (37.8%) and <450 μm in 2 (5.4%).
  
  
  CONCLUSIONS
  In this study, corneal thickness was less in children with Down syndrome than in healthy control subjects. Decreased corneal thickness may be an early sign of a degenerative corneal disease such as keratoconus in children with Down syndrome.
authors.affiliation: Ophthalmology Department, KSU Faculty of Medicine, Kahramanmaraş, Turkey. lokaslan46@yahoo.com
authors.forename: Lokman
authors.initials: L
authors.lastname: Aslan
authors.forename: Murat
authors.initials: M
authors.lastname: Aslankurt
authors.forename: Erdem
authors.initials: E
authors.lastname: Yüksel
authors.forename: Murat
authors.initials: M
authors.lastname: Özdemir
authors.forename: Esin
authors.initials: E
authors.lastname: Aksakal
authors.forename: Yakup
authors.initials: Y
authors.lastname: Gümüşalan
authors.forename: Gökhan
authors.initials: G
authors.lastname: Özdemir
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000473:pathology*; D063171:Corneal Pachymetry / Q000379:methods*; D019781:Corneal Topography / Q000379:methods; D004314:Down Syndrome / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies