title: Fatal histoplasmosis in a non-HIV patient in French Guiana.
abstract: Histoplasmosis is an endemic fungal infection that causes no symptoms or minor self-limited illnesses in most cases. Severe forms are commonly reported in patients with immunodeficiency disorders; histoplasmosis is considered to be an opportunistic infection in patients with AIDS. We report a case of disseminated histoplasmosis in a patient with no induced active suppression of the immune response. The infection was fulminant, and antifungal treatment was delayed because of a misdiagnosis of tuberculosis.
authors.affiliation: Laboratoire hospitalo-universitaire de parasitologie mycologie, centre hospitalier de Cayenne, avenue des flamboyants, Cayenne, French Guiana. lncormier@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Cormier
authors.forename: N
authors.initials: N
authors.lastname: Perez
authors.forename: D
authors.initials: D
authors.lastname: Blanchet
authors.forename: P
authors.initials: P
authors.lastname: Couppié
authors.forename: B
authors.initials: B
authors.lastname: Carme
authors.forename: C
authors.initials: C
authors.lastname: Aznar
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D001938:Brazil / Q000208:ethnology; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D057210:Delayed Diagnosis; D003951:Diagnostic Errors; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D017809:Fatal Outcome; D005616:French Guiana; D018023:HIV Seronegativity; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007121:Immunocompetence; D008172:Lung Diseases, Fungal / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008906:Mining; D009784:Occupational Diseases / Q000175:diagnosis* / Q000188:drug therapy; D014391:Tuberculosis, Miliary / Q000175:diagnosis
chemical_list: D000935:Antifungal Agents; D000995:Antitubercular Agents; D000666:Amphotericin B