title: DNA thermodynamics shape chromosome organization and topology.
abstract: How much information is encoded in the DNA sequence of an organism? We argue that the informational, mechanical and topological properties of DNA are interdependent and act together to specify the primary characteristics of genetic organization and chromatin structures. Superhelicity generated in vivo, in part by the action of DNA translocases, can be transmitted to topologically sensitive regions encoded by less stable DNA sequences.
authors.affiliation: Jacobs University Bremen, School of Engineering and Science, Campus Ring 1, D-28759 Bremen, Germany. aat@mrc-lmb.cam.ac.uk
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Travers
authors.forename: Georgi
authors.initials: G
authors.lastname: Muskhelishvili
mesh_terms: D002875:Chromosomes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D016680:Genome, Bacterial / Q000235:genetics; D016681:Genome, Fungal / Q000235:genetics; D009690:Nucleic Acid Conformation; D013816:Thermodynamics
chemical_list: D004247:DNA