title: Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population.
abstract: BACKGROUND
  To compare the neocortical amyloid loads among cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) subjects with [(18)F]AV-45 positron emission tomography (PET).
  
  
  METHODS
  [(18)F]AV-45 PET was performed in 11 CN, 13 aMCI, and 12 AD subjects to compare the cerebral cortex-to-whole cerebellum standard uptake value ratios (SUVRs) of global and individual volumes of interest (VOIs) cerebral cortex. The correlation between global cortical [(18)F]AV-45 SUVRs and Mini-Mental State Examination (MMSE) scores was analyzed.
  
  
  RESULTS
  The global cortical [(18)F]AV-45 SUVRs were significantly different among the CN (1.08±0.08), aMCI (1.27±0.06), and AD groups (1.34±0.13) (p = 0.0003) with amyloidosis positivity rates of 9%, 62%, and 92% in the three groups respectively. Compared to CN subjects, AD subjects had higher SUVRs in the global cortical, precuneus, frontal, parietal, occipital, temporal, and posterior cingulate areas; while aMCI subjects had higher values in the global cortical, precuneus, frontal, occipital and posterior cingulate areas. There were negative correlations of MMSE scores with SUVRs in the global cortical, precuneus, frontal, parietal, occipital, temporal, posterior cingulate and anterior cingulate areas on a combined subject pool of the three groups after age and education attainment adjustment.
  
  
  CONCLUSIONS
  Amyloid deposition occurs relatively early in precuneus, frontal and posterior cingulate in aMCI subjects. Higher [(18)F]AV-45 accumulation is present in parietal, occipital and temporal gyri in AD subjects compared to the aMCI group. Significant correlation between MMSE scores and [(18)F]AV-45 SUVRs can be observed among CN, aMCI and AD subjects.
authors.affiliation: Department of Neurology and Dementia Center, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
authors.forename: Kuo-Lun
authors.initials: KL
authors.lastname: Huang
authors.forename: Kun-Ju
authors.initials: KJ
authors.lastname: Lin
authors.forename: Ing-Tsung
authors.initials: IT
authors.lastname: Hsiao
authors.forename: Hung-Chou
authors.initials: HC
authors.lastname: Kuo
authors.forename: Wen-Chuin
authors.initials: WC
authors.lastname: Hsu
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Chuang
authors.forename: Mei-Ping
authors.initials: MP
authors.lastname: Kung
authors.forename: Shiaw-Pyng
authors.initials: SP
authors.lastname: Wey
authors.forename: Chia-Ju
authors.initials: CJ
authors.lastname: Hsieh
authors.forename: Yau-Yau
authors.initials: YY
authors.lastname: Wai
authors.forename: Tzu-Chen
authors.initials: TC
authors.lastname: Yen
authors.forename: Chin-Chang
authors.initials: CC
authors.lastname: Huang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism*; D000647:Amnesia / Q000175:diagnosis / Q000378:metabolism*; D000682:Amyloid / Q000378:metabolism*; D044466:Asian People; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D000682:Amyloid; D019788:Fluorodeoxyglucose F18