title: Proteomic signatures implicate cAMP in light and temperature responses in Arabidopsis thaliana.
abstract: The second messenger 3'-5'-cyclic adenosine monophosphate (cAMP) and adenylyl cyclases (ACs), enzymes that catalyse the formation of cAMP from ATP, are increasingly recognized as important signaling molecules in a number of physiological responses in higher plants. Here we used proteomics to identify cAMP-dependent protein signatures in Arabidopsis thaliana and identify a number of differentially expressed proteins with a role in light- and temperature-dependent responses, notably photosystem II subunit P-1, plasma membrane associated cation-binding protein and chaperonin 60 β. Based on these proteomics results we conclude that, much like in cyanobacteria, algae and fungi, cAMP may have a role in light signaling and the regulation of photosynthesis as well as responses to temperature and we speculate that ACs could act as light and/or temperature sensors in higher plants.
  
  
  CONCLUSIONS
  This current study is significant since it presents the first proteomic response to cAMP, a novel and key second messenger in plants. It will be relevant to researchers in plant physiology and in particular those with an interest in second messengers and their role in biotic and abiotic stress responses.
authors.affiliation: Proteomics core laboratory, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
authors.forename: Ludivine
authors.initials: L
authors.lastname: Thomas
authors.forename: Claudius
authors.initials: C
authors.lastname: Marondedze
authors.forename: Luisa
authors.initials: L
authors.lastname: Ederli
authors.forename: Stefania
authors.initials: S
authors.lastname: Pasqualini
authors.forename: Chris
authors.initials: C
authors.lastname: Gehring
mesh_terms: D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006358:Hot Temperature; D008027:Light; D015290:Second Messenger Systems / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D029681:Arabidopsis Proteins; D000242:Cyclic AMP