title: Correlation between serum adiponectin and risk factors in patients with coronary artery disease.
abstract: BACKGROUND
  To investigate the correlation between serum adiponectin (ADP) and high sensitivity C-reactive protein (hsCRP) as well as risk factors in patients with coronary artery disease (CAD).
  
  
  METHODS
  90 patients with coronary artery disease (CAD) who were subjected to coronary angiography were involved. Among the patients, 41 had acute myocardial infarction (AMI), 27 had unstable angina pectoris (UAP), and 22 had stable angina pectoris (SAP). 20 healthy people comprised the control group (NC). Serum ADP was measured using an enzyme linked immunosorbent assay (ELISA). hsCRP was measured using immunoturbidimetry. Cardiovascular risk factors were also investigated.
  
  
  RESULTS
  The serum ADP concentrations in the AMI group and the UAP group were significantly lower than those in the SAP group (p < 0.05) and the NC group (p < 0.01). The hsCRP concentrations in the AMI group and the UAP group were significantly higher than those in the SAP group (p < 0.05) and the NC group (p < 0.05). The ADP concentration was negatively correlated with the hsCRP concentration in the acute coronary syndrome group (r = -0.33, p < 0.05). Moreover, the more risk factors there were, the lower the serum ADP concentration in the CAD patients was.
  
  
  CONCLUSIONS
  Serum ADP is associated with CAD and cardiovascular risk factors. ADP has anti-inflammatory and anti-atherogenic properties, which may have a predictive value for the genesis and development of ACS.
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Suxin
authors.initials: S
authors.lastname: Luo
authors.forename: Han
authors.initials: H
authors.lastname: Lei
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000244:Adenosine Diphosphate / Q000097:blood; D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D000244:Adenosine Diphosphate; D002097:C-Reactive Protein