title: Acantholactone, a new manzamine related alkaloid with an unprecedented δ-lactone and ε-lactam ring system.
abstract: A new manzamine-related alkaloid with unprecedented δ-lactone and ε-lactam rings called acantholactone (2), was isolated from the Indonesian spongeAcanthostrongylophorasp. The relative configuration of the two new ring systems was established through detailed analysis of NOESY correlations combined with molecular modeling studies. The absolute configuration of2was determined as 12S, 24R, 25R, 26Rby comparing the computed electronic circular dichroism (ECD) spectra with experimental values.
authors.affiliation: Department of Pharmacognosy, The School of Pharmacy, The University of Mississippi, University, MS 38677, USA ; Department of Chemistry, Faculty of Science, Damietta University, Egypt.
authors.forename: Amir E
authors.initials: AE
authors.lastname: Wahba
authors.forename: Yann
authors.initials: Y
authors.lastname: Fromentin
authors.forename: Yike
authors.initials: Y
authors.lastname: Zou
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
keywords: Manzamine alkaloids