title: A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature.
abstract: Acute myelogenous leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. Specific cytogenetic abnormalities have been identified by karyotype analysis in AML. One of the rare chromosomal abnormalities is a dicentric chromosome, which is defined as an aberrant chromosome having two centromeres. In the literature, a limited number of cases have been reported with dic(1;15) in myeloid disorders, but only one case has been reported with in acute megakaryoblastic leukemia. Herein, we report a case of acute myelogenous leukemia without maturation with a dic(1;15)(p11;p11), resulting in trisomy of the long arm of chromosome 1. To date, this is the second case of dic(1;15) in acute myelogenous leukemia and the first case in acute myeloblastic leukemia without maturation.
authors.affiliation: Department of Hematology, School of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, Turkey.
authors.forename: Deniz Gören
authors.initials: DG
authors.lastname: Sahin
authors.forename: Beyhan
authors.initials: B
authors.lastname: Durak
authors.forename: Eren
authors.initials: E
authors.lastname: Gündüz
authors.forename: Sevilhan
authors.initials: S
authors.lastname: Artan
authors.forename: Olga Meltem
authors.initials: OM
authors.lastname: Akay