title: Mechanical support as failure intervention in patients with cavopulmonary shunts (MFICS): rationale and aims of a new registry of mechanical circulatory support in single ventricle patients.
abstract: It is now recognized that a majority of single ventricle patients, those with functionally univentricular hearts, who have survived palliative cavopulmonary connection will experience circulatory failure and end-organ dysfunction due to intrinsic inadequacies of a circulation supported by a single ventricle. Thus, there are an increasing number of patients with functional single ventricles presenting with failing circulations that may benefit from mechanical circulatory support (MCS). The paucity of experience with MCS in this population, even at high volume cardiac centers, contributes to limited available data to guide MCS device selection and management. Thus, a registry of MCS in this population would be beneficial to the field. A conference was convened in January 2012 of pediatric and adult cardiologists, pediatric cardiac intensivists, congenital heart surgeons, and adult cardiothoracic surgeons to discuss the current state of MCS, ventricular assist device, and total artificial heart therapy for patients who have undergone cavopulmonary connection, either superior cavopulmonary connection or total cavopulmonary connection. Specifically, individual experience and challenges with VAD therapy in this population was reviewed and creation of a multiinstitutional registry of MCS/ventricular assist device in this population was proposed. This document reflects the consensus from the meeting and provides a descriptive overview of the registry referred to as Mechanical Support as Failure Intervention in Patients with Cavopulmonary Shunts.
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. rossanoj@email.chop.edu
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Rossano
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Woods
authors.forename: Stuart
authors.initials: S
authors.lastname: Berger
authors.forename: J William
authors.initials: JW
authors.lastname: Gaynor
authors.forename: Nancy
authors.initials: N
authors.lastname: Ghanayem
authors.forename: David L S
authors.initials: DL
authors.lastname: Morales
authors.forename: Chitra
authors.initials: C
authors.lastname: Ravishankar
authors.forename: Michael E
authors.initials: ME
authors.lastname: Mitchell
authors.forename: Tejas K
authors.initials: TK
authors.lastname: Shah
authors.forename: Claudius
authors.initials: C
authors.lastname: Mahr
authors.forename: James S
authors.initials: JS
authors.lastname: Tweddell
authors.forename: Iki
authors.initials: I
authors.lastname: Adachi
authors.forename: Steven
authors.initials: S
authors.lastname: Zangwill
authors.forename: Peter D
authors.initials: PD
authors.lastname: Wearden
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Icenogle
authors.forename: Robert D
authors.initials: RD
authors.lastname: Jaquiss
authors.forename: Jack
authors.initials: J
authors.lastname: Rychik
mesh_terms: D032921:Consensus; D003326:Coronary Circulation; D018610:Heart Bypass, Right / Q000009:adverse effects*; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006352:Heart Ventricles / Q000002:abnormalities / Q000503:physiopathology / Q000601:surgery*; D006353:Heart-Assist Devices / Q000592:standards; D006439:Hemodynamics; D006801:Humans; D015337:Multicenter Studies as Topic; D017410:Practice Guidelines as Topic; D012039:Regional Blood Flow; D012042:Registries / Q000592:standards; D017211:Treatment Failure; D016276:Ventricular Function