title: Parahydrogen-induced polarization transfer to 19F in perfluorocarbons for 19F NMR spectroscopy and MRI.
abstract: Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen-induced polarization (PHIP) is applied to enhance (19)F MR signals of (perfluoro-n-hexyl)ethene and (perfluoro-n-hexyl)ethane. Unexpectedly, the end-standing CF3 group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non-intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and (19)F-(19)F NOESY spectra, as well as (19)F T1 values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF3 group, first (19)F MR images of hyperpolarized linear semifluorinated alkenes were recorded.
authors.affiliation: Department of Biometry and Medical Informatics, Otto-von-Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany. markus.plaumann@med.ovgu.de
authors.forename: Markus
authors.initials: M
authors.lastname: Plaumann
authors.forename: Ute
authors.initials: U
authors.lastname: Bommerich
authors.forename: Thomas
authors.initials: T
authors.lastname: Trantzschel
authors.forename: Denise
authors.initials: D
authors.lastname: Lego
authors.forename: Sonja
authors.initials: S
authors.lastname: Dillenberger
authors.forename: Grit
authors.initials: G
authors.lastname: Sauer
authors.forename: Joachim
authors.initials: J
authors.lastname: Bargon
authors.forename: Gerd
authors.initials: G
authors.lastname: Buntkowsky
authors.forename: Johannes
authors.initials: J
authors.lastname: Bernarding
mesh_terms: D005466:Fluorocarbons / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons
chemical_list: D005466:Fluorocarbons; D011522:Protons; D006859:Hydrogen