title: [Prenatal diagnosis of single umbilical artery: implications for chromosomal abnormalities and neonatal outcome].
abstract: OBJECTIVE
  To investigate the implications of a prenatal diagnosis of single umbilical artery (SUA) for chromosomal abnormalities and neonatal outcomes.
  
  
  METHODS
  From January, 2008 to June, 2012, color Doppler ultrasound identified 44 fetuses with SUA. Prenatal diagnoses with amniocentesis or umbilical blood sampling were subsequently ordered for routine chromosome karyotyping and the newborns were followed up for assessing the neonatal outcomes.
  
  
  RESULTS
  Of all the 44 fetuses, 24 had uncomplicated SUA, and 20 had other concurrent abnormalities (including 8 with abnormal ultrasound soft indexes and 12 with chromosomal abnormalities). The two groups of fetuses showed significant differences in gestational weeks at delivery and incidence of chromosomal abnormalities but not in neonatal weight, placenta weight or APGAR score.
  
  
  CONCLUSIONS
  Fetuses with a prenatal diagnosis of SUA and other development abnormities need to undergo prenatal chromosomal examination. For fetuses with uncomplicated SUA, careful ultrasound examination is necessary to avoid missed diagnosis of potential congenital abnormalities.
authors.affiliation: Department of Genecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. qxchang2010@yahoo.cn
authors.forename: Qingxian
authors.initials: Q
authors.lastname: Chang
authors.forename: Cuihua
authors.initials: C
authors.lastname: Chen
authors.forename: Mei
authors.initials: M
authors.lastname: Zhong
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Qiu
authors.forename: Chaoqun
authors.initials: C
authors.lastname: Xiao
authors.forename: Qitao
authors.initials: Q
authors.lastname: Huang
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000328:Adult; D025063:Chromosome Disorders / Q000000981:diagnostic imaging* / Q000235:genetics; D005260:Female; D005333:Fetus / Q000002:abnormalities; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D058529:Single Umbilical Artery / Q000000981:diagnostic imaging*; D016216:Ultrasonography, Prenatal; D055815:Young Adult