title: Atherosclerosis subclinical and inflammatory markers in obese and nonobese children and adolescents.
abstract: We conducted a systematic review of intima-media thickness(IMT) and inflammatory markers, compared IMT and identified by meta-analysis related to EMI and inflammatory variables in obese and non-obese children and adolescents. We searched for articles in databases Pubmed, Bireme and Science Direct, during years 2000 to 2010, with the following key words in English: "obesity", "adolescents", "atherosclerosis" and "child ", They were used in two combinations: obesity + adolescents + atherosclerosis + child + obesity and atherosclerosis. We used meta-analysis to compare IMT between obese and non-obese patients. We carefully selected 16 articles for final analysis. There were differences in the thickness of IMT between obese and non-obese patients in 12 studies, confirmed by meta-analysis. Obese patients had concentrations of C-reactive protein higher in 13 articles analyzed (p < 0.05) and lower adiponectin levels in 4 (p < 0.05). In general, obese men had lower concentrations of adiponectin and higher values of IMT and C-reactive protein than non-obese men, showing the relationship between obesity and early inflammatory process. We concluded that there is a relationship of obesity with increased IMT and changes in concentrations of inflammatory markers in this phase.
authors.affiliation: Departamento de Educação Física, Universidade Federal do Paraná, Brazil. larisilva99@yahoo.com.br
authors.forename: Larissa R
authors.initials: LR
authors.lastname: Silva
authors.forename: Joice M F
authors.initials: JM
authors.lastname: Stefanello
authors.forename: Juliana
authors.initials: J
authors.lastname: Pizzi
authors.forename: Luciana S
authors.initials: LS
authors.lastname: Timossi
authors.forename: Neiva
authors.initials: N
authors.lastname: Leite
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D059168:Carotid Intima-Media Thickness; D002648:Child; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications / Q000473:pathology; D015201:Meta-Analysis as Topic; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000473:pathology
chemical_list: D015415:Biomarkers