title: Interactions of a periplasmic binding protein with a tetradentate siderophore mimic.
abstract: Iron-bound structure: The ferric complex of a tetradentate siderophore mimic was synthesized and co-crystallized with the periplasmic binding protein CeuE of Campylobacter jejuni. In addition to electrostatic and hydrogen-bonding interactions between the binding pocket and the substrate, the structure showed direct coordination of two amino acid side chains to the Fe(III) center (orange, see figure).
authors.affiliation: Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Raines
authors.forename: Olga V
authors.initials: OV
authors.lastname: Moroz
authors.forename: Keith S
authors.initials: KS
authors.lastname: Wilson
authors.forename: Anne-K
authors.initials: AK
authors.lastname: Duhme-Klair
mesh_terms: D000595:Amino Acid Sequence; D040761:Biomimetic Materials / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry*; D008958:Models, Molecular; D033902:Periplasmic Binding Proteins / Q000737:chemistry*; D017262:Siderophores / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D033902:Periplasmic Binding Proteins; D017262:Siderophores