title: Chlorhexidine application in adhesive procedures: a meta-regression analysis.
abstract: OBJECTIVE
  To evaluate the association between chlorhexidine application and the bond strength of an adhesive system to dentin and to assess the association among eight other variables.
  
  
  METHODS
  Laboratory studies evaluating the use of chlorhexidine on dentin that verified the immediate and longitudinal bond strength were included. The terms were selected according to the Medical Subject Headings (MeSH) for PubMed and adapted for the other databases accordingly. Systematic searches were conducted in 3 electronic databases in December 2010: PubMed, EMBASE, and LILACS. Languages were limited to English, Spanish, and Portuguese.
  
  
  RESULTS
  All longitudinal bond strength studies were analyzed in accordance with the inclusion/exclusion criteria, totaling 16 articles. A meta-regression analysis was performed with articles containing complete mean bond strength data (n = 14 articles).
  
  
  CONCLUSIONS
  Our results showed that the association between the concentration of chlorhexidine and the bond strength is, apparently, not linear. Therefore, future large-scale studies should be developed to investigate the association between the chlorhexidine concentration and hybrid layer preservation.
authors.affiliation: Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grandedo Sul, Porto Alegre, RS, Brazil. fabricio.collares@ufrgs.br
authors.forename: Fabrício Mezzomo
authors.initials: FM
authors.lastname: Collares
authors.forename: Stéfani Becker
authors.initials: SB
authors.lastname: Rodrigues
authors.forename: Vicente Castelo
authors.initials: VC
authors.lastname: Leitune
authors.forename: Roger Keller
authors.initials: RK
authors.lastname: Celeste
authors.forename: Fernando
authors.initials: F
authors.lastname: Borba de Araújo
authors.forename: Susana Maria
authors.initials: SM
authors.lastname: Samuel
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000009:adverse effects*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000009:adverse effects*; D001840:Dental Bonding; D003799:Dental Stress Analysis; D003804:Dentin / Q000187:drug effects / Q000201:enzymology; D017220:Dentin-Bonding Agents; D019229:Dentition, Permanent; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors / Q000494:pharmacology; D020782:Matrix Metalloproteinases / Q000378:metabolism; D012044:Regression Analysis; D013718:Tensile Strength; D014094:Tooth, Deciduous
chemical_list: D000891:Anti-Infective Agents, Local; D017220:Dentin-Bonding Agents; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases; D002710:Chlorhexidine