title: Antihyperglycemic effect of Ginkgo biloba extract in streptozotocin-induced diabetes in rats.
abstract: The Ginkgo biloba extract (GBE) has been reported to have a wide range of health benefits in traditional Chinese medicine. The aim of this study was to evaluate the antihyperglycemic effects of GBE on streptozotocin- (STZ-) induced diabetes in rats. Diabetes was induced in male Wistar rats by the administration of STZ (60 mg/kg b.w.) intraperitoneally. GBE (100, 200, and 300 mg/kg b.w.) was administered orally once a day for a period of 30 days. Body weight and blood glucose levels were determined in different experimental days. Serum lipid profile and antioxidant enzymes in hepatic and pancreatic tissue were measured at the end of the experimental period. Significant decreases in body weight and antioxidant ability and increases in blood glucose, lipid profile, and lipid peroxidation were observed in STZ-induced diabetic rats. The administration of GBE and glibenclamide daily for 30 days in STZ-induced diabetic rats reversed the above parameters significantly. GBE possesses antihyperglycemic, antioxidant, and antihyperlipidemia activities in STZ-induced chronic diabetic rats, which promisingly support the use of GBE as a food supplement or an adjunct treatment for diabetics.
authors.affiliation: Department of Transfusion, The First Hospital of China Medical University, North Nanjing Street No. 155, Shenyang 110001, China. dayecheng_cmu@yahoo.cn
authors.forename: Daye
authors.initials: D
authors.lastname: Cheng
authors.forename: Bin
authors.initials: B
authors.lastname: Liang
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Li
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005609:Free Radicals; D020441:Ginkgo biloba / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D015227:Lipid Peroxidation; D008297:Male; D018384:Oxidative Stress; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D005609:Free Radicals; D007004:Hypoglycemic Agents; D010936:Plant Extracts