title: The MHC2TA 1614 C>G gene polymorphism is associated with risk of developing acute coronary syndrome.
abstract: BACKGROUND
  Inflammation plays an essential role in the development and progression of atherosclerotic lesions. The major histocompatibility complex class II trans-activator (MHC2TA) is considered an important molecule in the inflammatory process regulation. The aim of the present study was to evaluate the role of MHC2TA gene polymorphisms as susceptibility markers for acute coronary syndrome (ACS).
  
  
  METHODS
  Three polymorphisms (-168 A>G, 1614 C>G, and 2536 G>A) of the MHC2TA gene were analyzed by 5' exonuclease TaqMan genotyping assays in a group of 297 patients with ACS and 283 healthy controls. Haplotypes were constructed after linkage disequilibrium analysis.
  
  
  RESULTS
  The 1614 C allele and CC genotype were associated with risk of developing ACS (PC=0.014, OR=1.37 and PC=0.006, OR=1.90, respectively). Based on Hosmer-Lemeshow Goodness of Fit test, the recessive model was selected to estimate risk between ACS patients and controls adjusted by cardiovascular risk factors using a multiple logistic analysis. In this case, the OR adjusted was 1.78 for the 1614 CC genotype (P=0.023). The analysis of linkage disequilibrium showed one risk haplotype (ACG) and one protective haplotype (AGG) for developing ACS (P=0.02, OR=1.5 and P=0.04, OR=0.72, respectively).
  
  
  CONCLUSIONS
  The results suggest that MHC2TA 1614 gene polymorphism could be involved in the risk of developing ACS.
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Martínez-Ríos
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Peña-Duque
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
authors.forename: Guillermo
authors.initials: G
authors.lastname: Cardoso-Saldaña
authors.forename: Maite
authors.initials: M
authors.lastname: Vallejo
authors.forename: Julián
authors.initials: J
authors.lastname: Ramírez-Bello
authors.forename: Oscar
authors.initials: O
authors.lastname: Pérez-Méndez
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics* / Q000276:immunology*; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D015534:Trans-Activators / Q000235:genetics*
chemical_list: C083728:MHC class II transactivator protein; D009687:Nuclear Proteins; D015534:Trans-Activators