title: Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder.
abstract: Major depressive disorder (MDD) is a long-term, recurrent condition that often takes a chronic course. It seems imperative that research should be focused on gaining a better understanding of what predicts recurrent MDD. As a major mediator of the stress response, corticotropin-releasing-hormone receptor 1 (CRHR1) has been demonstrated to be an important contributor to the pathogenesis of MDD. In this study, we show a significant increase in the G-allele (rs242939) of the CRHR1 gene in the recurrent MDD group compared with the control group, and an overrepresentation of G-G-T hyplotype of the CRHR1 gene in recurrent MDD. We also demonstrate the interaction of the CRHR1 gene and negative life events in recurrent MDD. These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood.
authors.affiliation: Department of Psychiatry, Renmin Hospital, Wuhan University, Wuhan, China.
authors.forename: Zhongchun
authors.initials: Z
authors.lastname: Liu
authors.forename: Wanhong
authors.initials: W
authors.lastname: Liu
authors.forename: Lihua
authors.initials: L
authors.lastname: Yao
authors.forename: Can
authors.initials: C
authors.lastname: Yang
authors.forename: Ling
authors.initials: L
authors.lastname: Xiao
authors.forename: Qirong
authors.initials: Q
authors.lastname: Wan
authors.forename: Kai
authors.initials: K
authors.lastname: Gao
authors.forename: Huiling
authors.initials: H
authors.lastname: Wang
authors.forename: Fan
authors.initials: F
authors.lastname: Zhu
authors.forename: Gaohua
authors.initials: G
authors.lastname: Wang
authors.forename: Zheman
authors.initials: Z
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D003865:Major Depressive Disorder / Q000235:genetics* / Q000523:psychology*; D005260:Female; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics*; D012008:Recurrence; D055815:Young Adult; D000099052:CRF Receptor, Type 1
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1