title: Beneficial effects of habitual resistance exercise training on coagulation and fibrinolytic responses.
abstract: BACKGROUND
  A sedentary lifestyle is a major risk factor for cardiovascular and thrombotic complications. While habitual endurance activity will reduce the risk of these adverse events, the influence of habitual resistance exercise is less clear. This study examined coagulation and fibrinolytic responses to an acute exhaustive resistance exercise test (AERET) in both resistance-trained (RT, min 2 yr, 5 men and 5 women) and untrained (UT, 5 men and 5 women) subjects.
  
  
  METHODS
  The AERET consisted of six sets of 10 repetitions of squats at 80% of 1-repetition maximum. Venous blood was collected pre-exercise, immediate post exercise (IP), and +15, +60, and +120 minutes post exercise.
  
  
  RESULTS
  Compared to UT, RT exhibited a lower capacity to form a clot as seen by activated partial Thromboplastin time (aPTT) integrated area under the curve over time (iAUC) levels, lower pre-exercise and 120 min post-exercise plasminogen activator inhibitor -1 (PAI-1) activity, and higher tissue plasminogen activator (tPA) activity immediately post-exercise. There were no significant differences between RT and UT for fibrinogen, prothrombin fragment 1+2 (PTF 1+2), and thrombin-antithrombin complexes (TAT).
  
  
  CONCLUSIONS
  These results suggest that habitual resistance exercise training may provide an enhanced fibrinolytic state.
authors.affiliation: Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 2095 Hillside Road, Unit 1110, Storrs, CT 06269-1110, United States. Brian.kupchak@uconn.edu
authors.forename: Brian R
authors.initials: BR
authors.lastname: Kupchak
authors.forename: Brent C
authors.initials: BC
authors.lastname: Creighton
authors.forename: Juan C
authors.initials: JC
authors.lastname: Aristizabal
authors.forename: Courtenay
authors.initials: C
authors.lastname: Dunn-Lewis
authors.forename: Brittanie M
authors.initials: BM
authors.lastname: Volk
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Ballard
authors.forename: Brett A
authors.initials: BA
authors.lastname: Comstock
authors.forename: Carl M
authors.initials: CM
authors.lastname: Maresh
authors.forename: William J
authors.initials: WJ
authors.lastname: Kraemer
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Volek
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D055070:Resistance Training; D010959:Tissue Plasminogen Activator / Q000378:metabolism
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator