title: [Association between plasma leptin level and periodontal parameters in patients with aggressive periodontitis].
abstract: OBJECTIVE
  To detect the plasma leptin levels in patients with aggressive periodontitis (AgP) and to analyze the relationship between circulating leptin level and periodontal condition.
  
  
  METHODS
  A total of 97 patients with AgP and 44 healthy controls were recruited. Detailed clinical examinations were conducted and clinical parameters such as bleeding index (BI), probing depth (PD), attachment loss (AL) were recorded. Plasma leptin level was measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The plasma leptin level in AgP group was significantly higher than that of control subjects [(20.0 ± 4.3) µg/L vs. (7.5 ± 1.3) µg/L, P < 0.01)]. The plasma leptin level was positively related to BI, PD and AL, and the r values were 0.647, 0.596 and 0.632 respectively (P < 0.01).
  
  
  CONCLUSIONS
  Plasma leptin concentration in AgP patients was significantly elevated compared with healthy controls. Circulating leptin level was positively related to periodontal parameters including BI, PD and AL.
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
authors.forename: Yun-yu
authors.initials: YY
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Dong
authors.initials: D
authors.lastname: Shi
authors.forename: Zhi-bin
authors.initials: ZB
authors.lastname: Cheng
authors.forename: Huan-xin
authors.initials: HX
authors.lastname: Meng
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood* / Q000175:diagnosis; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D017622:Periodontal Attachment Loss / Q000097:blood / Q000175:diagnosis; D010512:Periodontal Index; D010949:Plasma / Q000378:metabolism; D055815:Young Adult
chemical_list: D020738:Leptin