title: Spectrum of hemoglobinopathies among the primitive tribes: a multicentric study in India.
abstract: We evaluated the spectrum of hemoglobinopathies among the primitive tribal groups from 4 states in India. A total of 15,200 individuals from 14 primitive tribal groups were studied by automated high-performance liquid chromatography. The hemoglobin S (HbS) allele frequency varied from 0.011 to 0.120 and the β-thalassemia allele frequency from 0.005 to 0.024. It is interesting to note that a very high HbS allele frequency was observed among the Dravidian (0.060-0.120) and Indo-European (0.060-0.076) as compared with Austro-Asiatic (0.011-0.022) speaking tribal groups. Although statistical analysis of the data did not show any ethnic differences within the states, regional differences were observed between the states for both HbS and β-thalassemia traits. HbS was found to be the most common hemoglobinopathy followed by β-thalassemia. A health plan for identifying sickle-cell homozygotes in the neonatal period with proper medical intervention is desirable.
authors.affiliation: National Institute of Immunohaematology (ICMR), Mumbai, India mohantydipika09@gmail.com.
authors.forename: Dipika
authors.initials: D
authors.lastname: Mohanty
authors.affiliation: National Institute of Immunohaematology (ICMR), Mumbai, India.
authors.forename: Malay B
authors.initials: MB
authors.lastname: Mukherjee
authors.affiliation: National Institute of Immunohaematology (ICMR), Mumbai, India.
authors.forename: Roshan B
authors.initials: RB
authors.lastname: Colah
authors.affiliation: National Institute of Immunohaematology (ICMR), Mumbai, India.
authors.forename: Mahrukh
authors.initials: M
authors.lastname: Wadia
authors.affiliation: National Institute of Immunohaematology (ICMR), Mumbai, India.
authors.forename: Kanjaksha
authors.initials: K
authors.lastname: Ghosh
authors.affiliation: Regional Medical Research Centre (ICMR), Bhubaneshwar, India.
authors.forename: Guru Prasad
authors.initials: GP
authors.lastname: Chottray
authors.affiliation: Government Medical College, Nagpur, India.
authors.forename: Dipty
authors.initials: D
authors.lastname: Jain
authors.affiliation: Bulsar Raktadan Kendra, Valsad, India.
authors.forename: Yazdi
authors.initials: Y
authors.lastname: Italia
authors.affiliation: Nilgiri Adivasi Welfare Association, Nilgiri, India.
authors.forename: Kumar S
authors.initials: KS
authors.lastname: Ashokan
authors.affiliation: Indian Council of Medical Research, New Delhi, India.
authors.forename: Rajni
authors.initials: R
authors.lastname: Kaul
authors.affiliation: Indian Council of Medical Research, New Delhi, India.
authors.forename: Deepak K
authors.initials: DK
authors.lastname: Shukla
authors.affiliation: Indian Council of Medical Research, New Delhi, India.
authors.forename: Vasantha
authors.initials: V
authors.lastname: Muthuswamy
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005787:Gene Frequency; D006451:Hemoglobin, Sickle / Q000235:genetics; D006453:Hemoglobinopathies / Q000208:ethnology*; D006801:Humans; D007194:India / Q000453:epidemiology; D044382:Population Groups
chemical_list: D006451:Hemoglobin, Sickle
keywords: India; anemia; hemoglobinopathies; primitive tribes