title: Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer.
abstract: The blockade of the PD-1 pathway can increase the production of interferon γ by tumor-specific T cells located within or in the proximity of the malignant lesion, thereby increasing the chemokine-dependent trafficking of immune effector cells. This can boost the efficacy of adoptive T-cell therapy to achieve superior antitumor responses.
authors.affiliation: Department of Melanoma Medical Oncology; The Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center; Houston, TX USA.
authors.forename: Weiyi
authors.initials: W
authors.lastname: Peng
authors.forename: Gregory
authors.initials: G
authors.lastname: Lizée
authors.forename: Patrick
authors.initials: P
authors.lastname: Hwu
keywords: PD-1; PD-L1; adoptive cell therapy; cancer immunotherapy; checkpoint blockade; melanoma