title: A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.
abstract: Monoamine oxidase (MAO) enzyme inhibition is a crucial target for the management of depression and Alzheimer disease and inhibitors of MAO are the most important drugs for their management. Coumarins are a large family of compounds, of natural and synthetic origin, that exhibit a variety of pharmacological activities, including MAO inhibition. The current review highlights the design and synthetic methods of coumarin derivatives as well as coumarins obtained from plant source as MAO inhibitors for treatment of depression and Alzheimer disease with salient finding related to structure-activity relationship. The aim of present review is to find out natural as well as synthetic coumarins as MAO inhibitors.
authors.affiliation: Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur District, Dhule 425405, Maharashtra, India. rxpatilpravin@yahoo.co.in
authors.forename: Pravin O
authors.initials: PO
authors.lastname: Patil
authors.forename: Sanjay B
authors.initials: SB
authors.lastname: Bari
authors.forename: Sandip D
authors.initials: SD
authors.lastname: Firke
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Deshmukh
authors.forename: Shailesh T
authors.initials: ST
authors.lastname: Donda
authors.forename: Dilip A
authors.initials: DA
authors.lastname: Patil
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D003374:Coumarins; D008996:Monoamine Oxidase Inhibitors; C030123:coumarin; D008995:Monoamine Oxidase