title: Fluid therapy LiDCO controlled trial-optimization of volume resuscitation of extensively burned patients through noninvasive continuous real-time hemodynamic monitoring LiDCO.
abstract: This pilot trial aims at gaining support for the optimization of acute burn resuscitation through noninvasive continuous real-time hemodynamic monitoring using arterial pulse contour analysis. A group of 21 burned patients meeting preliminary criteria (age range 18-75 years with second- third- degree burns and TBSA ≥10-75%) was randomized during 2010. A hemodynamic monitoring through lithium dilution cardiac output was used in 10 randomized patients (LiDCO group), whereas those without LiDCO monitoring were defined as the control group. The modified Brooke/Parkland formula as a starting resuscitative formula, balanced crystalloids as the initial solutions, urine output of 0.5 ml/kg/hr as a crucial value of adequate intravascular filling were used in both groups. Additionally, the volume and vasopressor/inotropic support were based on dynamic preload parameters in the LiDCO group in the case of circulatory instability and oligouria. Statistical analysis was done using t-tests. Within the first 24 hours postburn, a significantly lower consumption of crystalloids was registered in LiDCO group (P = .04). The fluid balance under LiDCO control in combination with hourly diuresis contributed to reducing the cumulative fluid balance approximately by 10% compared with fluid management based on standard monitoring parameters. The amount of applied solutions in the LiDCO group got closer to Brooke formula whereas the urine output was at the same level in both groups (0.8 ml/kg/hr). The new finding in this study is that when a fluid resuscitation is based on the arterial waveform analysis, the initial fluid volume provided was significantly lower than that delivered on the basis of physician-directed fluid resuscitation (by urine output and mean arterial pressure).
authors.affiliation: From the *Third Faculty of Medicine, Charles University, Prague Burn Center, Faculty Hospital Kralovske Vinohrady, Prague, Czech Republic; †Department of Clinical and Experimental Medicine, Linköping University, Sweden; ‡Department of Anesthesiology, Resuscitation and Intensive Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.
authors.forename: Monika
authors.initials: M
authors.lastname: Tokarik
authors.forename: Folke
authors.initials: F
authors.lastname: Sjöberg
authors.forename: Martin
authors.initials: M
authors.lastname: Balik
authors.forename: Igor
authors.initials: I
authors.lastname: Pafcuga
authors.forename: Ludomir
authors.initials: L
authors.lastname: Broz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002056:Burns / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D002302:Cardiac Output / Q000502:physiology; D000077324:Crystalloid Solutions; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000502:physiology; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D015601:Injury Severity Score; D007552:Isotonic Solutions / Q000494:pharmacology; D008094:Lithium; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D010865:Pilot Projects; D011446:Prospective Studies; D012016:Reference Values; D012151:Resuscitation / Q000379:methods* / Q000401:mortality; D018570:Risk Assessment; D012769:Shock / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D008094:Lithium