title: Transmembrane halogen-bonding cascades.
abstract: Halogen bonds have recently been introduced as ideal to transport anions across lipid bilayer membranes. However, activities obtained with small transporters were not impressive, and cyclic arrays of strong halogen-bond donors above a calix[4]arene scaffold gave even weaker activities. Here, we report that their linear alignment for anion hopping along transmembrane rigid-rod scaffolds gives excellent activities with an unprecedented cooperativity coefficient m = 3.37.
authors.affiliation: Department of Organic Chemistry, University of Geneva, Geneva, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Vargas Jentzsch
authors.forename: Stefan
authors.initials: S
authors.lastname: Matile
mesh_terms: D006219:Halogens / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D006219:Halogens; D008051:Lipid Bilayers