title: [Applications of numerical simulation in musculoskeletal research and its impact on orthopedic surgery].
abstract: Finite element analyses (FEA) as well as multibody system dynamics (MSD) are the main tools used for numerical simulation in the field of musculoskeletal research. While FEA is utilized for field problems, such as calculation of stress and strain distribution, MSD is applied for solving kinematic analyses, such as calculation of muscle and joint forces. Depending on the focus of investigation, modelling of biological tissue may vary from simple homogeneous behavior to modelling biochemical processes on the microscale and nanoscale. An important milestone in biomechanical research was the analysis of stress shielding, which led to further research on bone remodelling. Various models of implant-bone fixation used for the prediction of micromotion have been published. New possibilities for biomechanical analyses are achieved by consideration of complex muscle forces which are generated by MSD simulation and imported into FEA models as limiting conditions. A numerical model always requires experimental validation. If the results are confirmed experimentally, various advantages of numerical simulation apply and problems can be analysed isolated from many influencing factors. Therefore, straightforward parameter variation is possible, enabling studies which would be impossible in an experimental or clinical setup.
authors.affiliation: Forschungslabor für Biomechanik und Implantattechnologie, Orthopädische Klinik und Poliklinik, Universitätsmedizin Rostock, Doberaner Str. 142, 18057, Rostock, Deutschland. daniel.kluess@med.uni-rostock.de
authors.forename: D
authors.initials: D
authors.lastname: Kluess
authors.forename: C
authors.initials: C
authors.lastname: Hurschler
authors.forename: C
authors.initials: C
authors.lastname: Voigt
authors.forename: A
authors.initials: A
authors.lastname: Hölzer
authors.forename: M
authors.initials: M
authors.lastname: Stoffel
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends*; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D009142:Musculoskeletal Physiological Phenomena; D009141:Musculoskeletal System / Q000601:surgery*; D009716:Numerical Analysis, Computer-Assisted; D019637:Orthopedic Procedures / Q000639:trends*; D025321:Surgery, Computer-Assisted / Q000639:trends*