title: CD19+CD5+ B cells and B1-like cells following allogeneic hematopoietic stem cell transplantation.
abstract: We and others have previously reported the expansion of CD5(+)CD19(+) B cells after allogeneic hematopoietic stem cell transplantation. Recently, the equivalent of B1 cells in mice has been described in humans as CD20(+)CD27(+)CD43(+)CD70(-) B cells. In this article, we report that although 39% of CD5(+)CD19(+) cells were CD43(+) in controls, >75% of CD5(+)CD19(+) cells were CD43(+) in patients independent of the presence or absence of chronic graft-versus-host disease (GVHD) (P = .0001). CD5(+)CD19(+) B cell, CD5(+)CD43(+)CD19(+) B cell, and CD27(+)CD43(+) B cell counts were significantly lower in the patients with previous chronic GVHD, and this effect of GVHD was similar in both CD5(+) and CD5(-) within the CD27(+)CD43(+) B cell subset. Our results strongly suggest that the previously reported expansion of the CD5(+)CD19(+) population might be related to an expansion of the CD27(+)CD43(+) B cell subset and that CD27(+)CD43(+) B cell reconstitution is impaired in patients with chronic GVHD.
authors.affiliation: INSERM UMRS-940, Institut Universitaire d'Hématologie, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Moins-Teisserenc
authors.forename: Marc
authors.initials: M
authors.lastname: Busson
authors.forename: Adel
authors.initials: A
authors.lastname: Herda
authors.forename: Sandrine
authors.initials: S
authors.lastname: Apete
authors.forename: Regis
authors.initials: R
authors.lastname: Peffault de Latour
authors.forename: Marie
authors.initials: M
authors.lastname: Robin
authors.forename: Aliénor
authors.initials: A
authors.lastname: Xhaard
authors.forename: Antoine
authors.initials: A
authors.lastname: Toubert
authors.forename: Gérard
authors.initials: G
authors.lastname: Socié
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology*; D049109:Cell Proliferation; D002908:Chronic Disease; D015870:Gene Expression; D006086:Graft vs Host Disease / Q000276:immunology / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016130:Immunophenotyping; D014184:Transplantation, Homologous
chemical_list: D015703:Antigens, CD