title: Antifeedant activity of spin-labeled derivatives of deoxypodophyllotoxin against Brontispa longissima larvae.
abstract: To continue our search for natural product-based compounds for the control of Brontispa longissima larvae, eight spin-labeled podophyllotoxin derivatives (4a-h) and the intermediates 2 and 3 were tested for their insect antifeedant activity against third-instar larvae of B. longissima. Among all the tested compounds, 4a, 4c, 2 and 3 showed pronounced antifeedant activities with AFC50 values of 0.16, 0.31, 0.15 and 0.28 mg/mL, respectively. The different antifeedant activity ranges of these compounds indicated that variation of the structures of L-amino acids in these compounds markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it.
authors.affiliation: Key Laboratory of Integrated Pest Management on Tropical Crops, Ministry of Agriculture, Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Science, Danzhou 571737, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.forename: Ying-Qian
authors.initials: YQ
authors.lastname: Liu
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhang
authors.forename: Xuan
authors.initials: X
authors.lastname: Tian
authors.forename: Qi-An
authors.initials: QA
authors.lastname: Jin
authors.forename: Zheng-Qiang
authors.initials: ZQ
authors.lastname: Peng
mesh_terms: D000818:Animals; D001517:Coleoptera / Q000254:growth & development*; D004365:Drugs, Chinese Herbal; D007814:Larva / Q000187:drug effects; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013113:Spin Labels; D013329:Structure-Activity Relationship
chemical_list: D004365:Drugs, Chinese Herbal; D013113:Spin Labels; C014451:deoxypodophyllotoxin; D011034:Podophyllotoxin