title: Importance of high-density lipoprotein cholesterol control during pravastatin treatment in hypercholesterolemic Japanese with type 2 diabetes mellitus: a post hoc analysis of MEGA study.
abstract: To investigate the role of HDL-C in cardiovascular risk reduction, we evaluated using data from a diabetic population in a large clinical trial with pravastatin. A significant risk reduction in CVD was found only in diabetic patients who had both a reduction in LDL-C and an increase in HDL-C.
authors.affiliation: Jikei University School of Medicine, Tokyo, Japan. rimei@jikei.ac.jp
authors.forename: Rimei
authors.initials: R
authors.lastname: Nishimura
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakagami
authors.forename: Naoko
authors.initials: N
authors.lastname: Tajima
mesh_terms: D000924:Anticholesteremic Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000097:blood* / Q000178:diet therapy / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000627:therapeutic use*
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017035:Pravastatin