title: Comparison of the effects of Mg-6Zn and titanium on intestinal tract in vivo.
abstract: To evaluate the ability of Mg-6Zn to replace titanium nails in the reconstruction of the intestinal tract in general surgery, we compared the Mg-6Zn and titanium implants with respect to their effects on rat's intestinal tract by biochemical, radiological, pathological and immunohistochemical methods. The results indicated that Mg-6Zn implants started to degrade at the third week and disintegrate at the fourth week. No bubbles appeared, which may be associated with intestinal absorption of the Mg-6Zn implants. Pathological analyses (containing liver, kidney and cecum tissues) and biochemical measurements, including serum magnesium, creatinine, blood urea nitrogen, glutamic-pyruvic-transaminase and glutamic-oxaloacetic-transaminase proved that degradation of Mg-6Zn did not harm the important organs, which is an improvement over titanium implants. Immunohistochemical results showed that Mg-6Zn could enhance the expression of transforming growth factor-β1. Mg-6Zn reduced the expression of tumor necrosis factor at different stages. In general, our study demonstrates that the Mg-6Zn alloy had good biocompatibility in vivo and performed better than titanium at promoting healing and reducing inflammation. It may be a promising candidate for stapler pins in intestinal reconstruction.
authors.affiliation: Shanghai Jiaotong University School of Medicine, 227 South Chongqing Road, Shanghai 200025, People's Republic of China. junyan007@yahoo.com.cn
authors.forename: Jun
authors.initials: J
authors.lastname: Yan
authors.forename: Yigang
authors.initials: Y
authors.lastname: Chen
authors.forename: Qingling
authors.initials: Q
authors.lastname: Yuan
authors.forename: Song
authors.initials: S
authors.lastname: Yu
authors.forename: Wencai
authors.initials: W
authors.lastname: Qiu
authors.forename: Chengguang
authors.initials: C
authors.lastname: Yang
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Gong
authors.forename: Kaixing
authors.initials: K
authors.lastname: Ai
authors.forename: Qi
authors.initials: Q
authors.lastname: Zheng
authors.forename: Jianan
authors.initials: J
authors.lastname: Li
authors.forename: Shaoxiang
authors.initials: S
authors.lastname: Zhang
authors.forename: Xiaonong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000497:Alloys / Q000009:adverse effects / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry; D002432:Cecum / Q000601:surgery*; D008274:Magnesium / Q000009:adverse effects* / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D051381:Rats; D017207:Rats, Sprague-Dawley; D013537:Sutures / Q000009:adverse effects*; D014025:Titanium / Q000009:adverse effects*; D053706:Typhlitis / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control*; D015032:Zinc / Q000009:adverse effects* / Q000737:chemistry
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D014025:Titanium; D008274:Magnesium; D015032:Zinc