title: [Study on the effect of selective serotonin reuptake inhibitor fluoxetine on seizures and inborn behavior of rats with different phenotype of the nervous system].
abstract: Effects of increased levels of selective reuptake inhibitor fluoxetine were studied in Wistar male rats with different individual reactivity of the nervous system. Different behavioral models were used. In rats tolerant to audiogenic stress, drug administration led to a decrease in exploratory behaviour and increase in emotional excitability in the open-field test, whereas in rats with high predisposition to audiogenic seizures, this drug decreased emotional excitability and strength of seizure reactions. The results suggest the existence of anxiogenic, anxiolytic and anti-seizure effects of the drug in Wistar rats with different phenotype of the nervous system and different original brain monoamine levels.
authors.forename: Kh Iu
authors.initials: KhIu
authors.lastname: Ismaĭlova
authors.forename: M B
authors.initials: MB
authors.lastname: Miadzhidi
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D000927:Anticonvulsants / Q000008:administration & dosage; D015306:Biogenic Monoamines / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D005106:Exploratory Behavior / Q000187:drug effects*; D005473:Fluoxetine / Q000008:administration & dosage*; D006613:Higher Nervous Activity; D008297:Male; D009420:Nervous System / Q000187:drug effects / Q000503:physiopathology; D010641:Phenotype; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D015306:Biogenic Monoamines; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors