title: Clinical and radiologic features of unilateral and bilateral schizencephaly in polish pediatric patients.
abstract: Schizencephaly is a rare and severe congenital brain defect. Its etiology is not unequivocal and its clinical course differs with every case. The aim of the study was to analyze correlations between clinical and radiologic features of schizencephaly in Polish patients. The study group consisted of 25 children. Epileptic seizures were observed in 60% of cases and in 32% epilepsy was drug resistant. Generalized hypotonia was found in 24%, spastic diparesis in 48%, and spastic hemiparesis in 28% of cases. Seizures were more frequent in the bilateral than unilateral schizencephaly subgroup (72% vs 29%, P = .045). There was a correlation between the presence of the bilateral type II schizencephaly and the occurrence of seizures (P = .002, r = 0.578). There is a correlation between the type of schizencephaly and the presence of seizures in Polish pediatric patients. In most of the patients, schizencephaly leads to developmental retardation and epileptic seizures.
authors.affiliation: 1Department of Neuropediatrics, Medical University of Silesia, Katowice, Poland.
authors.forename: Ilona
authors.initials: I
authors.lastname: Kopyta
authors.forename: Ewa
authors.initials: E
authors.lastname: Jamroz
authors.forename: Ewa
authors.initials: E
authors.lastname: Kluczewska
authors.forename: Beata
authors.initials: B
authors.lastname: Sarecka-Hujar
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology*; D004827:Epilepsy / Q000150:complications / Q000175:diagnosis; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009123:Muscle Hypotonia / Q000150:complications / Q000175:diagnosis; D011044:Poland; D011859:Radiography; D065707:Schizencephaly / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D014055:Tomography, Emission-Computed
keywords: children; cleft; developmental delay; epilepsy; microgyria; schizencephaly