title: The plant-unique cis-element that mediates signaling from multiple endoplasmic reticulum stress sensors.
abstract: The accumulation of unfolded proteins in the ER lumen induces intracellular signaling mediated by the ER stress sensor protein IRE1. Our recent study identified a new common cis-element of ER stress-responsive genes (such as rice BiP paralogs and WRKY45) that were regulated via an IRE1-dependent pathway. ER stress-responsive cis-elements had been expected to be conserved between plants and mammals. However, contrary to expectations, sequences of the plant cis-element, pUPRE-II, were not identical to those of its mammalian counterpart. Additionally, pUPRE-II also interacted with another ER stress sensor protein and mediated multiple signaling pathways. Here, we provide a summary of the results that suggest the complicated mechanism underlying the regulation of ER stress-responsive gene expression in plants.
authors.affiliation: Genetically Modified Organism Research Center; National Institute of Agrobiological Sciences; Tsukuba, Ibaraki, Japan.
authors.forename: Shimpei
authors.initials: S
authors.lastname: Hayashi
authors.forename: Fumio
authors.initials: F
authors.lastname: Takaiwa
mesh_terms: D059865:Endoplasmic Reticulum Stress; D018506:Gene Expression Regulation, Plant; D006801:Humans; D012275:Oryza / Q000378:metabolism*
keywords: Oryza sativa; cis-elements; endoplasmic reticulum stress; plants; transcription factors; unfolded protein response