title: Efficacy of methods used for the diagnosis of bacterial vaginosis.
abstract: BACKGROUND
  Bacterial vaginosis (BV) has been associated with pelvic inflammatory disease, adverse pregnancy outcomes, increased susceptibility to sexually transmitted infections and infertility. Diagnosis of BV should be rapid, reliable and safe. This is especially vital in pregnant women where intervention may be necessary for the well-being of both the mother and the foetus.
  
  
  METHODS
  This paper consulted PUBMED, LISTA and Web of Science for point-of-care and laboratory-based tests commonly used for the diagnosis and management of BV in pregnant women. An overview of strengths and weaknesses of the methods used may partially explain why treatment plans have failed. Differences in sampling and detection methods, time of gestation, inter-examiner variability and interpretation of data, and the use of different reference tests, amongst many other factors, complicated a meta-analysis of the data.
  
  
  CONCLUSIONS
  Inconsistencies found in clinical and laboratory detection methods used for the monitoring of treatment have a direct impact on success rates. With current advances in technology, the diagnosis of BV is taking on a new perspective. New information implicating specific vaginal biofilms in adverse pregnancy outcomes through the application of advanced technology promises to change the way we view the aetiology, diagnosis and management of BV.
authors.affiliation: University of the Western Cape, Department of Medical Biosciences, Life Sciences Building, Cape Town, South Africa. cafrica@uwc.ac.za
authors.forename: Charlene W J
authors.initials: CW
authors.lastname: Africa
mesh_terms: D001431:Bacteriological Techniques; D005260:Female; D006801:Humans; D025202:Molecular Diagnostic Techniques; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D016585:Vaginosis, Bacterial / Q000175:diagnosis*