title: DAR2 acts as an important node connecting cytokinin, auxin, SHY2 and PLT1/2 in root meristem size control.
abstract: Cytokinin and auxin antagonistically affect cell proliferation and differentiation and thus regulate root meristem size by influencing the abundance of SHORT HYPOCOTYL2 (SHY2/IAA3). SHY2 affects auxin distribution in the root meristem by repressing the auxin-inducible expression of PIN-FORMED (PIN) auxin transport genes. The PLETHORA (PLT1/2) genes influence root meristem growth by promoting stem cells and transit-amplifying cells. However, the factors connecting cytokinin, auxin, SHY2 and PLT1/2 are largely unknown. In a recent study, we have shown that the DA1-related protein 2 (DAR2) acts downstream of cytokinin and SHY2 but upstream of PLT1/2 to affect root meristem size. Here, we discuss the possible molecular mechanisms by which Arabidopsis DAR2 controls root meristem size.
authors.affiliation: State Key Laboratory of Plant Cell and Chromosome Engineering; Institute of Genetics and Developmental Biology; Chinese Academy of Sciences; Beijing, China.
authors.forename: Yuancheng
authors.initials: Y
authors.lastname: Peng
authors.forename: Liangliang
authors.initials: L
authors.lastname: Chen
authors.forename: Yaru
authors.initials: Y
authors.lastname: Lu
authors.forename: Wenying
authors.initials: W
authors.lastname: Ma
authors.forename: Yiping
authors.initials: Y
authors.lastname: Tong
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Li
mesh_terms: D017360:Arabidopsis / Q000254:growth & development / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D003583:Cytokinins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D007210:Indoleacetic Acids / Q000378:metabolism; D018519:Meristem / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D003583:Cytokinins; C582826:DA1-related protein 2, Arabidopsis; D004268:DNA-Binding Proteins; D007210:Indoleacetic Acids; D009687:Nuclear Proteins; C493246:PLT1 protein, Arabidopsis; C493247:PLT2 protein, Arabidopsis; C117994:SHY2 protein, Arabidopsis; D014157:Transcription Factors
keywords: DAR2; auxin; cytokinin; root meristem size; stem cell niche activity