title: Molecular characterization and in vitro antifungal susceptibility profile of Schizophyllum commune, an emerging basidiomycete in bronchopulmonary mycoses.
abstract: Schizophyllum commune (n = 30) showed lowest geometric mean MICs of isavuconazole (0.19 μg/ml), itraconazole (0.2 μg/ml), voriconazole (0.24 μg/ml), and amphotericin B (0.29 μg/ml) and high geometric mean MICs of fluconazole (19.39 μg/ml) and flucytosine (17.28 μg/ml). Five cases (of 8) of allergic bronchopulmonary mycosis that were treated with itraconazole had no recrudescence after 6 to 24 months of follow-up. One case each of invasive pulmonary mycosis and fungal ball were treated successfully with voriconazole and itraconazole.
authors.affiliation: Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Chowdhary
authors.forename: Shallu
authors.initials: S
authors.lastname: Kathuria
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Singh
authors.forename: Kshitij
authors.initials: K
authors.lastname: Agarwal
authors.forename: Shailendra N
authors.initials: SN
authors.lastname: Gaur
authors.forename: Pradip
authors.initials: P
authors.lastname: Roy
authors.forename: Harbans S
authors.initials: HS
authors.lastname: Randhawa
authors.forename: Jacques F
authors.initials: JF
authors.lastname: Meis
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D017964:Itraconazole / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D012567:Schizophyllum / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D065819:Voriconazole