title: Maternal first-trimester dietary intake and childhood blood pressure: the Generation R Study.
abstract: Suboptimal maternal dietary intake during pregnancy might lead to fetal cardiovascular adaptations and higher blood pressure in the offspring. The aim of the present study was to investigate the associations of maternal first-trimester dietary intake with blood pressure in children at the age of 6 years. We assessed first-trimester maternal daily dietary intake by a FFQ and measured folate, homocysteine and vitamin B₁₂ concentrations in the blood, in a population-based prospective cohort study among 2863 mothers and children. Childhood systolic and diastolic blood pressure was measured using a validated automatic sphygmomanometer. First-trimester maternal daily intake of energy, fat, protein and carbohydrate was not associated with childhood blood pressure. Furthermore, maternal intake of micronutrients was not associated with childhood blood pressure. Also, higher maternal vitamin B₁₂ concentrations were associated with a higher diastolic blood pressure (0·31 mmHg per standard deviation increase in vitamin B₁₂ (95% CI 0·06, 0·56)). After taking into account multiple testing, none of the associations was statistically significant. Maternal first-trimester folate and homocysteine concentrations were not associated with childhood blood pressure. The results from the present study suggest that maternal Fe intake and vitamin B₁₂ concentrations during the first trimester of pregnancy might affect childhood blood pressure, although the effect estimates were small and were not significant after correction for multiple testing. Further studies are needed to replicate these findings, to elucidate the underlying mechanisms and to assess whether these differences in blood pressure persist in later life.
authors.affiliation: The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
authors.forename: Leontine C L
authors.initials: LC
authors.lastname: van den Hil
authors.forename: H
authors.initials: H
authors.lastname: Rob Taal
authors.forename: Layla L
authors.initials: LL
authors.lastname: de Jonge
authors.forename: Denise H M
authors.initials: DH
authors.lastname: Heppe
authors.forename: Eric A P
authors.initials: EA
authors.lastname: Steegers
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Albert J
authors.initials: AJ
authors.lastname: van der Heijden
authors.forename: Vincent W V
authors.initials: VW
authors.lastname: Jaddoe
mesh_terms: D001794:Blood Pressure; D002648:Child; D015331:Cohort Studies; D004032:Diet; D019587:Dietary Supplements / Q000032:analysis; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000737:chemistry; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D018977:Micronutrients / Q000032:analysis; D009426:Netherlands; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D018977:Micronutrients; D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12