title: Metabolic syndrome and cancer: from bedside to bench and back.
abstract: As older patients present with an average of three comorbidities beside their cancer, geriatric oncology can provide unique clues to translational research in aging and cancer. We illustrate this approach with the example of the metabolic syndrome and cancer. Epidemiologic and clinical cohorts highlighted an association between the metabolic syndrome and a higher risk and worse prognosis of various cancers. In a bedside-to-bench transition, this led to an interest in analyzing the potential mechanisms underlying this association. At least ten potential mechanisms could be implicated, with the challenge of understanding which are the dominant ones in human patients. Bench-to-bedside studies are beginning to shed some light on that aspect, and some therapeutic trials are beginning to exploit the lessons learned.
authors.affiliation: Senior Adult Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA. martine.extermann@moffitt.org
authors.forename: Martine
authors.initials: M
authors.lastname: Extermann
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D015897:Comorbidity; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D007249:Inflammation / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism; D009369:Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D011379:Prognosis; D011493:Protein Kinase C / Q000378:metabolism; D012307:Risk Factors; D057170:Translational Research, Biomedical; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D017127:Glycation End Products, Advanced; D007328:Insulin; D047492:Peroxisome Proliferator-Activated Receptors; D042461:Vascular Endothelial Growth Factor A; D007334:Insulin-Like Growth Factor I; D011493:Protein Kinase C