title: Building a sulfonamide library by eco-friendly flow synthesis.
abstract: A rapid and eco-friendly synthesis of a sulfonamide library under flow conditions is described. The study illustrates an efficient, safe, and easily scalable preparation of sulfonamides by use of a meso-reactor apparatus, thus demonstrating the impact of flow technologies within drug discovery. Waste minimization, employment of green media, and nontoxic reactants are achieved by the optimization of the flow setup and experimental protocol designed to sequentially synthesize primary, secondary, and tertiary sulfonamides. Isolation of the products involves only extraction and precipitation affording pure compounds in good to high yields without further purification for biological evaluation.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia , Via del Liceo, 1, 06123 Perugia, Italy.
authors.forename: Antimo
authors.initials: A
authors.lastname: Gioiello
authors.forename: Emiliano
authors.initials: E
authors.lastname: Rosatelli
authors.forename: Michela
authors.initials: M
authors.lastname: Teofrasti
authors.forename: Paolo
authors.initials: P
authors.lastname: Filipponi
authors.forename: Roberto
authors.initials: R
authors.lastname: Pellicciari
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D013449:Sulfonamides / Q000138:chemical synthesis*
chemical_list: D013449:Sulfonamides