title: Incidence and prevalence of cancer in kidney transplantation waiting list patients: an Italian experience.
abstract: BACKGROUND
  Evaluation of kidney transplant candidates is based on strict exclusion of major pathologies, such as neoplastic disease. The aim of this study is to evaluate epidemiological and clinical impact of tumor disease in an Italian renal transplant waiting list and to propose a screening schedule for neoplastic detection.
  
  
  METHODS
  We retrospectively observed data of patients enrolled on the Emilia-Romagna kidney transplant waiting list between 1st August 2008 and 31st December 2010, evaluating the different causes of getting out from the list, the histologic type and incidence of cancer and the correlation between cancer onset and clinical features. The ratio of observed to expected cancer numbers (standardized incidence ratio, SIR), was estimated.
  
  
  RESULTS
  We observed 2345 patients; 1297 got out from the waiting list; 57 of them (4,4%) got out because the onset of tumor. The overall incidence rate of cancer was 1354.8 (x 100,000 person-year) (1045.9 person-year in patients awaiting for first transplant(FT), 1851.5 person-year in patients awaiting for second transplant(ST)). The overall prevalence of cancer was 2,43% (2.2% in FT, 3.4% in ST) with a SIR of 1.8; In our population the prevalence of cancers related to ESKD was 52.6% with a SIR of 15.8.
  
  
  CONCLUSIONS
  Kidney transplant waiting list patients present a higher incidence and prevalence of cancer compared to general population; it could be important to evaluate them for ESKD related malignancies because of their high incidence.
authors.affiliation: Section of Nephrology, Department of Internal Medicine, Aging and Renal Disease, St.Orsola Hospital, University of Bologna, Bologna, Italy. g.mosconi@libero.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Mosconi
authors.forename: Francesca
authors.initials: F
authors.lastname: Centofanti
authors.forename: Irene
authors.initials: I
authors.lastname: Capelli
authors.forename: Andrea
authors.initials: A
authors.lastname: Ricci
authors.forename: Elisa
authors.initials: E
authors.lastname: Persici
authors.forename: Ilaria
authors.initials: I
authors.lastname: Gandolfini
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Rubbiani
authors.forename: Carlo
authors.initials: C
authors.lastname: Buzio
authors.forename: Gianni
authors.initials: G
authors.lastname: Cappelli
authors.forename: Alessandro Nanni
authors.initials: AN
authors.lastname: Costa
authors.forename: Sergio
authors.initials: S
authors.lastname: Stefoni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D013997:Time Factors; D014850:Waiting Lists; D055815:Young Adult