title: Copper-catalyzed direct ortho-alkylation of N-iminopyridinium ylides with N-tosylhydrazones.
abstract: Copper-catalyzed cross-coupling of N-tosylhydrazones with N-iminopyridinium ylides leads to the direct C-H alkylation. This direct C-H bond alkylation transformation uses inexpensive CuI as the catalyst without any ligand. The reaction is operationally simple and conducted under mild conditions, giving the corresponding alkylated pyridines in moderate to good yields. DFT calculation provides insights into the reaction mechanism, suggesting that the reaction proceeds through the Cu carbene migratory insertion process.
authors.affiliation: Beijing National Laboratory of Molecular Sciences, College of Chemistry, Peking University, Beijing 100871, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xiao
authors.forename: Lin
authors.initials: L
authors.lastname: Ling
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.forename: Renchang
authors.initials: R
authors.lastname: Tan
authors.forename: Leiming
authors.initials: L
authors.lastname: Tian
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yuxue
authors.initials: Y
authors.lastname: Li
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang