title: SLC13 family of Na⁺-coupled di- and tri-carboxylate/sulfate transporters.
abstract: The SLC13 family comprises five genes (SLC13A1, SLC13A2, SLC13A3, SLC13A4, and SLC13A5) encoding structurally related multi-spanning transporters (8-13 transmembrane domains) with orthologues found in prokaryotes and eukaryotes. Mammalian SLC13 members mediate the electrogenic Na(+)-coupled anion cotransport at the plasma membrane of epithelial cells (mainly kidney, small intestine, placenta and liver) or cells of the central nervous system. While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and α-ketoglutarate. All these transporters play a variety of physiological and pathophysiological roles in the different organs. Thus, the purpose of this review is to summarize the roles of SLC13 members in human physiology and pathophysiology and what the therapeutic perspectives are. We have also described the most recent advances on the structure, expression, function and regulation of SLC13 transporters.
authors.affiliation: Axe des Neurosciences Cellulaires et Moléculaires, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Université Laval, 2601 Chemin de Canardière, Québec, Canada G1J 2G3. marc.bergeron.2@ulaval.ca
authors.forename: M J
authors.initials: MJ
authors.lastname: Bergeron
authors.forename: B
authors.initials: B
authors.lastname: Clémençon
authors.forename: M A
authors.initials: MA
authors.lastname: Hediger
authors.forename: D
authors.initials: D
authors.lastname: Markovich
mesh_terms: D027682:Cation Transport Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D003998:Dicarboxylic Acids / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D005810:Multigene Family / Q000235:genetics*; D011487:Protein Conformation; D000077003:Sodium Sulfate Cotransporter; D027981:Symporters / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D014233:Tricarboxylic Acids / Q000378:metabolism
chemical_list: D027682:Cation Transport Proteins; D003998:Dicarboxylic Acids; D000077003:Sodium Sulfate Cotransporter; D027981:Symporters; D014233:Tricarboxylic Acids