title: Coronary stents: historical development, current status and future directions.
abstract: BACKGROUND
  Coronary angioplasty with stenting has revolutionized the treatment of coronary artery disease. This article describes the history of coronary angioplasty and stenting, reviews the contemporary stents and recommendations and highlights the on-going work and potential future directions.
  
  
  METHODS
  This review examined the data on coronary stents available in PubMed.
  
  
  RESULTS
  Coronary artery stenting is the treatment of choice for patients requiring coronary angioplasty. Stents, and particularly drug-eluting stents, reduce the risk of restenosis, but may be associated with the hazard of late stent thrombosis. Dual anti-platelet treatment is recommended for patients receiving coronary stents.
  
  
  RESULTS
  The selection of stents for various lesions and patients and the duration of anti-platelet therapy remain debated areas.
  
  
  CONCLUSIONS
  There are on-going preclinical and clinical studies to develop better stent platforms, more biocompatible polymers, novel anti-proliferative and anti-platelet drugs, pro-healing stents and bioresorbable scaffolds.
authors.affiliation: Thorax Centre, Erasmus Medical Centre, Rotterdam, The Netherlands. p.w.j.c.serruys@erasmus.nl
authors.forename: Javaid
authors.initials: J
authors.lastname: Iqbal
authors.forename: Julian
authors.initials: J
authors.lastname: Gunn
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D020341:Absorbable Implants; D015906:Angioplasty, Balloon, Coronary / Q000639:trends*; D003324:Coronary Artery Disease / Q000628:therapy*; D054855:Drug-Eluting Stents; D004867:Equipment Design; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D015607:Stents / Q000639:trends*
chemical_list: D010975:Platelet Aggregation Inhibitors
keywords: angioplasty; bare metal stents; bioresorbable vascular scaffold; drug-eluting stents; stents