title: Idiopathic thrombocytopenic purpura associated with splenic tuberculosis: case report.
abstract: Tuberculosis is still one of the most prevalent and fatal infectious diseases in spite of considerable improvements in medical science. Splenic tuberculosis is a rare form of extrapulmonary tuberculosis. There are limited numbers of cases in which immune thrombocytopenia is associated with splenic tuberculosis. We report a case of immune thrombocytopenic purpura due to splenic tuberculosis. Our case was a 58-year-old female with headache, gum bleeding, redness in legs, and ecchymoses on the arms for 10 days. On admission to hospital, laboratory tests were as follows: platelet count 6.000/mmc (150 000-450 000), haemoglobin: 12 g/dl, WBC: 8000/mm3, erythrocyte sedimentation rate: 58 mm/h and C-reactive protein was in normal ranges. After standard laboratory tests, the patient was diagnosed with idiopathic thrombocytopenic purpura. The patient presented abdominal lymphadenopathies and spleen in normal size in radiological examinations. Diagnostic laparotomy and splenectomy and lymph node excision was performed and splenic tuberculosis was detected in pathologic and microbiologic examination. The patient was successfully treated with apheresis platelets suspension, intravenous immunoglobulin and antituberculous therapy. In conclusion, splenic tuberculosis should be suspected in patients who have fever, abdominal lymphadenopathies and immune thrombocytopenic purpura. Histopathological examination is still an ideal method to confirm the diagnosis, suitably aided by microbiological examination.
authors.affiliation: Department of Hematology, Dicle University, Diyarbakir, Turkey.
authors.forename: Mehmet Sinan
authors.initials: MS
authors.lastname: Dal
authors.forename: Tuba
authors.initials: T
authors.lastname: Dal
authors.forename: Recep
authors.initials: R
authors.lastname: Tekin
authors.forename: Erdal
authors.initials: E
authors.lastname: Bodakçi
authors.forename: Yakup
authors.initials: Y
authors.lastname: Düzköprü
authors.forename: Mehmet Orhan
authors.initials: MO
authors.lastname: Ayyildiz
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004438:Ecchymosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000209:etiology; D006261:Headache / Q000209:etiology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008197:Lymph Node Excision; D008875:Middle Aged; D010976:Platelet Count; D017713:Platelet Transfusion / Q000379:methods; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D013156:Splenectomy; D016896:Treatment Outcome; D014400:Tuberculosis, Splenic / Q000150:complications* / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D034941:Upper Extremity / Q000473:pathology
chemical_list: D000995:Antitubercular Agents; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors