title: Cognitive outcome after on- and off-pump coronary artery bypass grafting surgery: a systematic review and meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to compare cognition following coronary artery bypass grafting (CABG) surgery with or without cardiopulmonary bypass (CPB) (on- or off-pump).
  
  
  METHODS
  Systematic review and meta-analysis of randomized control trials comparing cognitive outcome in patients undergoing CABG surgery on- or off-pump as assessed by continuous measures from a battery of 7 psychometric tests.
  
  
  METHODS
  Multi-institutional centers performing CABG surgery.
  
  
  METHODS
  Patients with coronary artery disease requiring CABG surgery.
  
  
  METHODS
  CABG surgery with or without CPB.
  
  
  RESULTS
  A structured literature search identified 13 randomized control trials that included a total of 2,405 patients. Results from 7 psychometric tests were grouped into early (≤3 months) and late (6-12 months) postoperative periods. No significant differences were found between on- and off-pump groups in any of the 7 psychometric tests in either the early (p range 0.21-0.78) or late (p range 0.09-0.93) postoperative period.
  
  
  CONCLUSIONS
  The results suggested that CPB may not be associated with cognitive decline that is associated with CABG surgery.
authors.affiliation: The University of Edinburgh, College of Medicine and Veterinary Medicine, Edinburgh, UK. E.D.Kennedy@sms.ed.ac.uk
authors.forename: Ewan D
authors.initials: ED
authors.lastname: Kennedy
authors.forename: Kevin C C
authors.initials: KC
authors.lastname: Choy
authors.forename: R Peter
authors.initials: RP
authors.lastname: Alston
authors.forename: Shaoyun
authors.initials: S
authors.lastname: Chen
authors.forename: Muhamed M H
authors.initials: MM
authors.lastname: Farhan-Alanie
authors.forename: Jamie
authors.initials: J
authors.lastname: Anderson
authors.forename: Yun Lin
authors.initials: YL
authors.lastname: Ang
authors.forename: Deborah E
authors.initials: DE
authors.lastname: Moore
authors.forename: Sam A
authors.initials: SA
authors.lastname: Mackenzie
authors.forename: Robert A
authors.initials: RA
authors.lastname: Sykes
mesh_terms: D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D023381:Endpoint Determination; D006801:Humans; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D009483:Neuropsychological Tests; D011184:Postoperative Period; D011594:Psychometrics; D017594:Publication Bias; D016032:Randomized Controlled Trials as Topic; D014145:Trail Making Test; D016896:Treatment Outcome