title: Realization of a poro-elastic ultrasound replica of pulmonary tissue.
abstract: In this work we describe the fabrication of a biocompatible hydrophilic scaffold composed of cross-linked gelatin that mimics the porous three-dimensional structure of pulmonary tissue as well as its water content and mechanical properties. The lung replica also reproduces the characteristic sonographic signs of pulmonary interstitial syndrome, the B-lines or ultrasound lung comets.
authors.affiliation: Interdepartmental Research Center E. Piaggio, University of Pisa, Pisa, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Spinelli
authors.forename: Bruna
authors.initials: B
authors.lastname: Vinci
authors.forename: Annalisa
authors.initials: A
authors.lastname: Tirella
authors.forename: Marco
authors.initials: M
authors.lastname: Matteucci
authors.forename: Luna
authors.initials: L
authors.lastname: Gargani
authors.forename: Arti
authors.initials: A
authors.lastname: Ahluwalia
authors.forename: Claudio
authors.initials: C
authors.lastname: Domenici
authors.forename: Eugenio
authors.initials: E
authors.lastname: Picano
authors.forename: Piero
authors.initials: P
authors.lastname: Chiarelli
mesh_terms: D000162:Acoustics; D001672:Biocompatible Materials / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D004548:Elasticity; D005780:Gelatin / Q000737:chemistry*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D017563:Lung Diseases, Interstitial / Q000503:physiopathology*; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D019047:Phantoms, Imaging; D016062:Porosity; D013314:Stress, Mechanical; D013997:Time Factors; D054457:Tissue Scaffolds; D014463:Ultrasonography; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D014867:Water; D005780:Gelatin; D003094:Collagen
keywords: B-lines; echographic signals; gelatin; hydrogels; lung replica; mechanical properties; porosity