title: Does acetylsalicylic acid or warfarin affect the accuracy of fecal occult blood tests?
abstract: BACKGROUND
  Current guidelines for screening of colorectal cancer do not offer specific recommendations for cessation of antithrombotic agents prior to fecal occult blood test (FOBT).
  
  
  OBJECTIVE
  To asess the accuracy of FOBT in patients taking acetylsalicylic acid (ASA) or warfarin.
  
  
  METHODS
  A literature search was conducted for studies that investigated the accuracy of FOBT in patients taking ASA and warfarin. The primary outcome was the pooled relative risk (RR) for true positive FOBT for detecting significant colonic neoplasia in patients taking ASA or warfarin compared with controls. The secondary outcome was a pooled RR for true positive in guaiac FOBT (g-FOBT) compared with immunochemical FOBT (i-FOBT).
  
  
  RESULTS
  Five observational studies included 759 patients taking ASA and 1652 control subjects. In patients taking ASA, pooled RR for true positive FOBT was 0.82 (95% confidence interval [CI] 0.73-0.93, P=0.0009), pooled RR for true positive g-FOBT was 0.69 (95% CI 0.60-0.79, P<0.0001), whereas pooled RR for true positive i-FOBT was 1.013 (95% CI 0.81-1.30, P=0.8182). Five observational studies included 806 patients taking warfarin and 10 338 control subjects. In patients taking warfarin, pooled RR for true positive FOBT was 1.559 (95% CI 1.349-1.801, P<0.0001).
  
  
  CONCLUSIONS
  The results of our meta-analysis demonstrate that in patients taking ASA, there is a decrease in the positive predictive value (PPV) of g-FOBT but no significant difference in the PPV of i-FOBT compared with control subjects for detecting significant neoplasia. In patients taking warfarin, the PPV of FOBT was increased for detection of colorectal cancer compared with control subjects.
authors.affiliation: Department of Medicine (Division of Internal Medicine), University of Toronto, Toronto, Canada.
authors.forename: Sumeet
authors.initials: S
authors.lastname: Gandhi
authors.forename: Neeraj
authors.initials: N
authors.lastname: Narula
authors.forename: Samir
authors.initials: S
authors.lastname: Gandhi
authors.forename: John K
authors.initials: JK
authors.lastname: Marshall
authors.forename: Michael E
authors.initials: ME
authors.lastname: Farkouh
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D006801:Humans; D009780:Occult Blood; D015203:Reproducibility of Results; D014859:Warfarin / Q000494:pharmacology*
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D001241:Aspirin