title: [A case of reversible encephalopathy syndrome caused by hyponatremia during neoadjuvant 5-FU+CDDP therapy for esophageal cancer].
abstract: We present a case of reversible encephalopathy syndrome caused by hyponatremia during neoadjuvant chemotherapy with 5-FU+CDDP for esophageal cancer. A 52-year-old woman visited another hospital with the complaint of discomfort during swallowing. Upper gastrointestinal endoscopy revealed an ulcerated lesion in the lower thoracic esophagus, which was pathologically diagnosed as squamous cell carcinoma. She was admitted to our institution, and the diagnosis of esophageal cancer Mt-Lt, type 2, cT2N1M0, stage II was made. We obtained informed consent for her treatment with both CRT and surgery, and she selected surgery. Therefore, she was administered neoadjuvant chemotherapy with 5-FU+CDDP therapy. On day 4, abnormalities of the central nerve, such as unconsciousness, difficulty in speaking, and muscle cramps were, observed. After the examinations she was diagnosed with encephalopathy. It should be noted that hyponatremia induced by renal sodium wasting syndrome(RSWS)was considerd to be the cause, and we report our case with the literature cited.
authors.affiliation: Dept. of Surgery, National Hospital Organization, Shikoku Cancer Center, Japan.
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Isao
authors.initials: I
authors.lastname: Nozaki
authors.forename: Shinji
authors.initials: S
authors.lastname: Hato
authors.forename: Takaya
authors.initials: T
authors.lastname: Kobatake
authors.forename: Koji
authors.initials: K
authors.lastname: Ohta
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Kubo
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanada
authors.forename: Akira
authors.initials: A
authors.lastname: Kurita
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004938:Esophageal Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging
chemical_list: D002945:Cisplatin; D005472:Fluorouracil