title: Regulation of postsynaptic retrograde signaling by presynaptic exosome release.
abstract: Retrograde signals from postsynaptic targets are critical during development and plasticity of synaptic connections. These signals serve to adjust the activity of presynaptic cells according to postsynaptic cell outputs and to maintain synaptic function within a dynamic range. Despite their importance, the mechanisms that trigger the release of retrograde signals and the role of presynaptic cells in this signaling event are unknown. Here we show that a retrograde signal mediated by Synaptotagmin 4 (Syt4) is transmitted to the postsynaptic cell through anterograde delivery of Syt4 via exosomes. Thus, by transferring an essential component of retrograde signaling through exosomes, presynaptic cells enable retrograde signaling.
authors.affiliation: Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors.forename: Ceren
authors.initials: C
authors.lastname: Korkut
authors.forename: Yihang
authors.initials: Y
authors.lastname: Li
authors.forename: Kate
authors.initials: K
authors.lastname: Koles
authors.forename: Cassandra
authors.initials: C
authors.lastname: Brewer
authors.forename: James
authors.initials: J
authors.lastname: Ashley
authors.forename: Motojiro
authors.initials: M
authors.lastname: Yoshihara
authors.forename: Vivian
authors.initials: V
authors.lastname: Budnik
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D055354:Exosomes / Q000737:chemistry / Q000378:metabolism*; D009469:Neuromuscular Junction / Q000737:chemistry / Q000378:metabolism; D017729:Presynaptic Terminals / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000737:chemistry / Q000378:metabolism; D055366:Synaptic Potentials / Q000502:physiology*; D050857:Synaptotagmins / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D050857:Synaptotagmins