title: Minireview: Obesity and breast cancer: a tale of inflammation and dysregulated metabolism.
abstract: In addition to the spectrum of conditions known collectively as the Metabolic Syndrome, obesity is now recognized to be associated with increased risk of several cancers including colon, endometrial, and breast cancer. Obesity and carcinogenesis share 2 characteristics in common. On the one hand, they involve inflammatory pathways, and on the other hand, they involve dysregulated metabolism. In this review we focus on postmenopausal breast cancer and discuss the metabolic and cellular mechanisms whereby obesity and breast cancer are related. Because a majority of postmenopausal breast tumors are estrogen responsive, we include a discussion of the action of obesity-related factors on estrogen formation within the breast.
authors.affiliation: Prince Henry's Institute of Medical Research-Monash Medical Centre, Block E, Level 4246 Clayton Road, PO Box 5152, Clayton, Victoria-3168, Australia. evan.simpson@princehenrys.org
authors.forename: Evan R
authors.initials: ER
authors.lastname: Simpson
authors.forename: Kristy A
authors.initials: KA
authors.lastname: Brown
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D063646:Carcinogenesis / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology*; D009765:Obesity / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents