title: Invertebrate and fungal model organisms: emerging platforms for drug discovery.
abstract: Early-stage translational research programs have increasingly exploited yeast, worms and flies to model human disease. These genetically tractable organisms represent flexible platforms for small molecule and drug target discovery. This review highlights recent examples of how model organisms are integrated into chemical genomic approaches to drug discovery with an emphasis on fungal yeast, nematode Caenorhabditis elegans and fruit fly Drosophila melanogaster. The roles of these organisms are expanding as novel models of human disease are developed and novel high-throughput screening technologies are created and adapted for drug discovery.
authors.affiliation: Cambria Pharmaceuticals, 8A Henshaw St, MA 01801, Woburn, USA +1 781 938 1333 ; +1 781 938 9520 ; gstilwell@cambriapharma.com.
authors.forename: Geoff E
authors.initials: GE
authors.lastname: Stilwell
authors.forename: Bethany
authors.initials: B
authors.lastname: Westlund