title: Castleman's disease in the orbit of a 17-year-old girl: a case report.
abstract: Castleman's disease is an atypical lympho proliferative disorder comprising hyaline vascular elements, plasma cells, or a mixture of both, which can present in unicentric or multicentric fashion. Resection of unicentric lesions is typically curative, but multicentric disease, also characterized by constitutional symptoms and a poorer prognosis, often requires treatment with chemotherapy, radiation, steroids, or immune modulators. Castleman's disease is rarely diagnosed in the orbit. The authors present the clinical and histopathological findings of a 17-year-old who was found to have a focal lesion in her orbit. She was successfully treated with surgical resection and was free of disease recurrence or other sequelae at 10-months follow up.
authors.affiliation: *Princeton University, Princeton, New Jersey; †Department of Surgery and §Department of Pathology, NorthShore University HealthSystem, Evanston, Illinois; ‡Department of Ophthalmology, Rush University Medical Center, Chicago, Illinois, U.S.A.
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Jones
authors.forename: Tamara R
authors.initials: TR
authors.lastname: Fountain
authors.forename: Beenu
authors.initials: B
authors.lastname: Thakral
authors.forename: Mohamed
authors.initials: M
authors.lastname: Eldibany
mesh_terms: D000293:Adolescent; D001706:Biopsy; D005871:Castleman Disease / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008279:Magnetic Resonance Imaging; D009916:Orbital Diseases / Q000175:diagnosis* / Q000601:surgery