title: Anti-Candida zeylanoides activity of some Iranian plants used in traditional medicine.
abstract: OBJECTIVE
  To assess anti-Candida zeylanoides activity of the essential oils (EOs) of five Iranian medicinal plants and to determine the different components of the EOs.
  
  
  METHODS
  Anti-C. zeylanoides effects of the EOs and reference drugs were determined by disc diffusion method. The EOs from Trachyspermum copticum, Zataria multiflora, Nigella sativa, Ziziphora clinopodiodes and Heracleum persicum were analyzed by gas chromatography/mass spectroscopy (GC/MS).
  
  
  RESULTS
  The mean values of inhibition zones were found to be more than 60mm for T. copticum, 56.7 mm for Z. multiflora, 40.8mm for N. sativa, 33.7 mm for Z. clinopodiodes and 18.7 mm for H. persicum. In GC/MS analysis, thymol (63.4%), carvacrol (61%), trans anthol (39%), pulegone (37%) and hexyl butyrate (30.2%) were found to be the major components of T. copticum, Z. multiflora, N. sativa, Z. clinopodiodes and H. persicum, respectively.
  
  
  CONCLUSIONS
  The EOs showed strong anti-C. zeylanoides activities, which strengthen the potential use of these substances for the treatment of candidiasis.
authors.affiliation: Faculty of Veterinary Medicine, University of Mazandaran, 24th, aftab Imam Khomeini Street, Amol 46168-49767, Iran. hshokri@umz.ac.ir
authors.forename: H
authors.initials: H
authors.lastname: Shokri
authors.forename: A
authors.initials: A
authors.lastname: Sharifzadeh
authors.forename: I
authors.initials: I
authors.lastname: Ashrafi Tamai
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D052978:Disk Diffusion Antimicrobial Tests; D004353:Drug Evaluation, Preclinical; D008401:Gas Chromatography-Mass Spectrometry; D007492:Iran; D008519:Medicine, Traditional; D009822:Oils, Volatile / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D009822:Oils, Volatile; D010938:Plant Oils