title: [Effect of therapy with diuretics on the functional activity of platelets in patients with arterial hypertension and abdominal obesity].
abstract: The aim of the study was to compare the influence of hypothiazide and indapamide on platelet aggregation in patients with arterial hypertension (AH) and abdominal obesity (AO). 28 and 31 patients were given hypothiazide and indapamide respectively for 16 weeks. The following parameters were estimated: blood lipid spectrum lipid peroxidation in plasma and platelets, platelet aggregation. The data obtained were treated using Student's t-test. Hypothiazide was shown to have beneficial effect on peroxidation syndrome and optimize platelet aggregation. These effects were further promoted by long-term indapamide therapy. Hypothiazide had no effect on the above parameters. It is concluded that a combination of indapamide with non-medicamental factors is needed to reduce body weight in patients with AH and AO.
authors.forename: V B
authors.initials: VB
authors.lastname: Simonenko
authors.forename: I N
authors.initials: IN
authors.lastname: Medvedev
authors.forename: A G
authors.initials: AG
authors.lastname: Briukhovetskiĭ
mesh_terms: D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood* / Q000150:complications; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count
chemical_list: D004232:Diuretics