title: Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective.
abstract: Manufacturers have developed prototype cigarettes yielding reduced levels of some tobacco smoke toxicants, when tested using laboratory machine smoking under standardised conditions. For the scientific assessment of modified risk tobacco products, tests that offer objective, reproducible data, which can be obtained in a much shorter time than the requirements of conventional epidemiology are needed. In this review, we consider whether biomarkers of biological effect related to oxidative stress can be used in this role. Based on published data, urinary 8-oxo-7,8-dihydro-2-deoxyguanosine, thymidine glycol, F2-isoprostanes, serum dehydroascorbic acid to ascorbic acid ratio and carotenoid concentrations show promise, while 4-hydroxynonenal requires further qualification.
authors.affiliation: British American Tobacco, Southampton, UK. frazer_lowe@bat.com
authors.forename: Frazer J
authors.initials: FJ
authors.lastname: Lowe
authors.forename: Karsta
authors.initials: K
authors.lastname: Luettich
authors.forename: Evan O
authors.initials: EO
authors.lastname: Gregg
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000447:Aldehydes / Q000652:urine; D001205:Ascorbic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002338:Carotenoids / Q000097:blood; D003683:Dehydroascorbic Acid / Q000097:blood; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D028441:F2-Isoprostanes / Q000652:urine*; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000652:urine; D018384:Oxidative Stress; D012306:Risk; D012907:Smoking / Q000009:adverse effects; D013936:Thymidine / Q000031:analogs & derivatives* / Q000652:urine; D062789:Tobacco Products / Q000009:adverse effects* / Q000032:analysis; D014028:Tobacco Smoke Pollution
chemical_list: D000447:Aldehydes; D015415:Biomarkers; D028441:F2-Isoprostanes; D014028:Tobacco Smoke Pollution; C029390:thymidine glycol; D002338:Carotenoids; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; C027576:4-hydroxy-2-nonenal; D001205:Ascorbic Acid; D013936:Thymidine; D003683:Dehydroascorbic Acid