title: Evaluation of the toxicity of Pradosia huberi extract during the preimplantation in Wistar rats.
abstract: The treatment during the embryonic preimplantation phase of Wistar rats with the Pradosia huberi extract did not interfere with the water and feed consumption, as well as upon the body-weight gain. However, it has expressed a decrease of the uterine implant number, followed by the preimplantation losses at all applied doses (1.22, 6.1, and 30.5 mg/kg), and the number of embryonic resorptions in the two highest doses (6.1 and 30.5 mg/kg). After the organ weighing (hypophysis, ovaries, and uterus), only the relative weight of the hypophysis was raised at the different doses (1.22, 6.1, and 30.5 mg/kg). It was concluded that the hydroalcoholic extract of Pradosia huberi compromises the reproductive ability during the embryonic preimplantation phase, suggesting a possible toxic effect upon the reproductive system of Wistar rats.
authors.affiliation: Biotechnology Center, Federal University of Paraíba, P.O. Box 5009, 58051-970 João Pessoa, PB, Brazil. aldeiderocha@hotmail.com
authors.forename: Aldeíde de Oliveira Batista
authors.initials: Ade O
authors.lastname: Rocha
authors.forename: Liliane de Queirós
authors.initials: Lde Q
authors.lastname: Sousa
authors.forename: Clélia de Alencar Xavier
authors.initials: Cde A
authors.lastname: Mota
authors.forename: Elane Cristina S
authors.initials: EC
authors.lastname: Santos
authors.forename: Margareth de Fátima Formiga Melo
authors.initials: Mde F
authors.lastname: Diniz
authors.forename: Marcelo Sobral
authors.initials: MS
authors.lastname: da Silva
authors.forename: Martina Bragante F
authors.initials: MB
authors.lastname: Pimenta
authors.forename: Rita de Cássia
authors.initials: Rde C
authors.lastname: da Silveira e Sá
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001755:Blastocyst / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D018811:Maternal Exposure; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D029632:Sapotaceae / Q000737:chemistry*
chemical_list: D010936:Plant Extracts