title: Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs.
abstract: OBJECTIVE
  The aim of this study was to analyze the outcomes of IVF/ICSI cycles in women aged 43 and beyond.
  
  
  METHODS
  Retrospective analysis of clinical pregnancy and live birth rates in 168 fresh, non donor, ART cycles performed in two Connecticut university IVF programs.
  
  
  RESULTS
  In women of 43 and 44 years the overall clinical pregnancy and live birth rates were 8.3% and 5.3% per initiated cycle, respectively. There were no clinical pregnancies in women ≥45 years old. First cycle characteristics were not different from repeated cycles in terms of duration of ovulation induction, number of collected oocytes and transferred embryos (p > 0.05).
  
  
  CONCLUSIONS
  Pregnancies can still be achieved with IVF/ICSI up to the age of 44. Since most pregnancies occurred within the first 3 cycles, another attempt may be a reasonable option before resorting to oocyte donation for patients who failed two previous cycles. Women 45 years and beyond do not benefit from ART procedures using their own oocytes.
authors.affiliation: Obstetrics, Gynecology and Reproductive Sciences, Yale University Fertility Center, New Haven, CT 06511, USA.
authors.forename: Mehmet B
authors.initials: MB
authors.lastname: Cetinkaya
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Siano
authors.forename: Claudio
authors.initials: C
authors.lastname: Benadiva
authors.forename: Denny
authors.initials: D
authors.lastname: Sakkas
authors.forename: Pasquale
authors.initials: P
authors.lastname: Patrizio
mesh_terms: D000328:Adult; D003237:Connecticut / Q000453:epidemiology; D004624:Embryo Transfer / Q000379:methods; D005260:Female; D005307:Fertilization in Vitro; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D054315:Oocyte Retrieval / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data; D009865:Oocytes / Q000166:cytology; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome