title: Prediagnosis soy food consumption and lung cancer survival in women.
abstract: OBJECTIVE
  We recently reported an inverse association between soy food intake and lung cancer risk among nonsmoking women. The effect size for aggressive lung cancers was larger than that observed for other types of lung cancer. Therefore, we hypothesized that soy consumption may favorably affect the overall survival of patients with lung cancer.
  
  
  METHODS
  This analysis included 444 women with incident lung cancer identified from the Shanghai Women's Health Study. Prediagnosis soy food intake was assessed at enrollment and reassessed 2 years later. Proportional hazards models were used to evaluate the association between soy food intake and overall survival.
  
  
  RESULTS
  Of the 444 patients with lung cancer, 318 died during follow-up. Initial analyses including all patients showed that higher intake of soy food was associated with better overall survival after adjusting for demographic and lifestyle characteristics and other nonclinical factors. Larger effect sizes for the association were found after additional adjustment for tumor stage and treatment in analyses including 301 patients with data available on these clinical factors. Compared with the median intake of soy food, fully adjusted hazard ratios for total mortality associated with the 10th, 30th, 70th, and 90th percentiles of intake were 1.81 (95% CI, 1.26 to 2.59), 1.25 (95% CI, 1.09 to 1.42), 0.88 (95% CI, 0.80 to 0.97), and 0.89 (95% CI, 0.68 to 1.16), respectively. Similar inverse associations were observed for dietary isoflavone intake.
  
  
  CONCLUSIONS
  This study suggests, to the best of our knowledge for the first time, that, among women with lung cancer, prediagnosis intake of soy food is associated with better overall survival.
authors.affiliation: Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA. gong.yang@vanderbilt.edu
authors.forename: Gong
authors.initials: G
authors.lastname: Yang
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Hong-Lan
authors.initials: HL
authors.lastname: Li
authors.forename: Wong-Ho
authors.initials: WH
authors.lastname: Chow
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wen
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Xianglan
authors.initials: X
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
authors.forename: Bu-Tian
authors.initials: BT
authors.lastname: Ji
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D004435:Eating; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D045730:Soy Foods / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D015996:Survival Rate