title: Safety of maternal long-term indomethacin tocolysis.
abstract: Indomethacin was utilized in 89 patients in preterm labor; the mean gestational age at the start of indomethacin therapy was 25.4 weeks (± 4.1), mean duration of indomethacin treatment was 43.9 days (± 31.3), mean gestational age at delivery was 33.6 weeks (± 3.2). Long-term ( > 48 h) indomethacin tocolysis evoked serious maternal side effects in 30.3% of patients studied. These side effects included exaggerated hypertensive responses in patients treated concomitantly with beta-blockers, gastric erosion and bleeding, fever, interstitial nephritis and postpartum hemorrhage.
authors.affiliation: Department of Obstetrics and Gynecology, Perinatal and Neonatal Division, Beilinson Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Schoenfeld
authors.forename: M
authors.initials: M
authors.lastname: Hod
authors.forename: P
authors.initials: P
authors.lastname: Merlob
authors.forename: S
authors.initials: S
authors.lastname: Friedman
authors.forename: J
authors.initials: J
authors.lastname: Ovadia