title: Effect of iloprost on erythrocyte deformability in rat's lower extremity undergoing an ischemia reperfusion injury.
abstract: OBJECTIVE
  Ischemia reperfusion injury (I/R) in lower extremity is a frequent and important clinical phenomenon. The protective effect of iloprost on local and distant organ injury due to I/R has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of iloprost on erythrocyte deformability in the infrarenal aorta of rats undergoing I/R.
  
  
  METHODS
  Our study was conducted with 18 Wistar albino rats. Rats were divided into the 3 groups; the randomized control group (group C; n=6), I/R group without iloprost (group I/R; n=6) and I/R group with iloprost - 10 mcg.kg-1, 30 min infusion (group I/R-I; n=6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were done.
  
  
  RESULTS
  The comparisons of the control and I/R-I groups revealed similar results (p=0.951). The values of the IR group were significantly higher than those of the control and IR-I groups (p=0.006, p=0.011, respectively).
  
  
  CONCLUSIONS
  In our study, we detected the unfavourable effects of I/R on erythrocyte deformability, which may lead to disturbance in blood flow and hence tissue perfusion in the infrarenal rat aorta. We also found that Iloprost had beneficial effects by reversing the undesirable effects of I/R (Fig. 1, Ref. 15).
authors.affiliation: Department of Anaesthesiology and Reanimation, Gazi University Medical Faculty, Ankara, Turkey. marslan36@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Arslan
authors.forename: T
authors.initials: T
authors.lastname: Donmez
authors.forename: D
authors.initials: D
authors.lastname: Erer
authors.forename: T
authors.initials: T
authors.lastname: Tatar
authors.forename: F M
authors.initials: FM
authors.lastname: Comu
authors.forename: M
authors.initials: M
authors.lastname: Alkan
mesh_terms: D000818:Animals; D004907:Erythrocyte Deformability / Q000187:drug effects*; D006614:Hindlimb / Q000098:blood supply; D016285:Iloprost / Q000494:pharmacology*; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D016285:Iloprost