title: Plasma oxidative stress is induced by single-sprint anaerobic exercise in young cigarette smokers.
abstract: Cigarette smoking increases oxidative stress, which is a risk factor for several diseases. Smoking has also been reported to enhance plasma oxidative stress during strenuous exercise. However, no prior study has examined the changes in plasma oxidative stress after single-sprint anaerobic exercise in cigarette smokers. The purpose of this study was to investigate these changes in young cigarette smokers by measuring reactive oxygen species generation and total antioxidant content. Participants were 15 male smokers (mean age: 25·9 ± 2·9 years) and 18 male non-smokers (mean age: 24·2 ± 4·3 years). Hydroperoxide concentration and biological antioxidant potential (BAP) in plasma were measured at baseline and after the Wingate anaerobic test. A significant interaction between group and time was observed for plasma hydroperoxide concentration (P = 0·037). Plasma hydroperoxide concentration was significantly increased after exercise in both smokers and non-smokers (P = 0·001 and <0·001, respectively). However, no significant interaction was observed between groups by time on plasma BAP (P = 0·574), and a main effect of time was observed (P<0·001). Plasma BAP was significantly increased after exercise in both groups (both, P<0·001). These findings indicate that plasma oxidative stress is higher in cigarette smokers than in non-smokers after single-sprint anaerobic exercise, which may increase the risk of oxidative damage.
authors.affiliation: Department of Health and Sports Medical Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Taito
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Sekikawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Oura
authors.forename: Norimichi
authors.initials: N
authors.lastname: Kamikawa
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Matsuki
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Kimura
authors.forename: Makoto
authors.initials: M
authors.lastname: Takahashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Inamizu
authors.forename: Hironobu
authors.initials: H
authors.lastname: Hamada
mesh_terms: D000328:Adult; D000367:Age Factors; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015444:Exercise; D005080:Exercise Test; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D008297:Male; D018384:Oxidative Stress; D012907:Smoking / Q000009:adverse effects / Q000097:blood*; D013997:Time Factors; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D006861:Hydrogen Peroxide