title: Day-long reduction of oral malodor by a palatal mucoadhesive tablet containing herbal formulation.
abstract: Previous research has shown the oral malodor reducing abilities of an herbal formulation delivered using a palatal mucoadhesive tablet. The aim of the present study was to test the day-long effect of this preventive treatment on oral malodor reduction as compared with placebo and commercial mouthwash. Forty young healthy subjects (mean age, 25.8 ± 1.8 yrs, 19 females) presenting with oral malodor were randomly assigned to use one of the three tested products: herbal mucoadhesive tablets, placebo mucoadhesive tablets and a commercial mouthwash. Following baseline measurements, subjects were instructed to use the products in the evening of the same day and the following morning. Baseline and follow-up measurements were conducted in the afternoon and included odor judge scores (two judges), volatile sulfide compounds (VSC) levels using a sulfide monitor (Halimeter™) and saliva sample for β-galactosidase activity assay. The herbal mucoadhesive tablet caused a significant reduction in malodor scores (p = 0.004), VSC levels (p = 0.002) and β-galactosidase assay (p = 0.02) as compared to the placebo, and reduced malodor level to below the clinical threshold (mean odor judge score of 1.7). These results demonstrate the efficacy of the herbal formulation delivered using a mucoadhesive tablet for day-long prevention of oral malodor.
authors.affiliation: Department of Prosthodontics, Goldschleger School of Dental Medicine, Tel-Aviv University, Ramat-Aviv 69978, Israel. drsterer@gmail.com
authors.forename: N
authors.initials: N
authors.lastname: Sterer
authors.forename: O
authors.initials: O
authors.lastname: Ovadia
authors.forename: E I
authors.initials: EI
authors.lastname: Weiss
authors.forename: M
authors.initials: M
authors.lastname: Perez Davidi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001944:Breath Tests / Q000379:methods*; D045853:Exhalation; D005260:Female; D005500:Follow-Up Studies; D006209:Halitosis / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D008297:Male; D010160:Palate, Soft; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D010946:Plants, Medicinal; D012463:Saliva / Q000737:chemistry*; D013607:Tablets; D013997:Time Factors; D055549:Volatile Organic Compounds / Q000032:analysis*
chemical_list: D010936:Plant Extracts; D013607:Tablets; D055549:Volatile Organic Compounds