title: Association of adiponectin with dietary factors and cardiovascular risk factors in type 2 diabetes mellitus patients.
abstract: OBJECTIVE
  Adiponectin, is an adipose tissue-specific adipokine, that circulates in human plasma at high levels, although lower levels are noted with insulin resistance and atherosclerosis. We investigated the relationship of adiponectin concentrations with dietary factors and some of the cardiovascular risk factors in patients with T2DM.
  
  
  RESULTS
  Totally 107 patients with T2DM were recruited from the out patients clinic of Shariati Hospital, Tehran, Iran. Patients were evaluated for laboratory and anthropometric measurements including serum adiponectin, fasting insulin, FPG, OGTT, HbA1c, HOMA-IR, hsCRP, weight, height, BMI and WHR. Nutrients intakes were obtained via 24-h recall from each patient in three successive days. Nutrients and data analysis were done using FPII and SPSS version 13 softwares. The mean of log10-transformed serum adiponectin concentration was 0.79±0.27μg/ml. The univariate linear regression analysis could not show any significant relation between the log of serum adiponectin and dietary factors. In multivariate linear regression after multiple adjustment, the log of serum adiponectin was independently associated with WHR (P=0.02, t=-2.33), HDL-C (P=0.050, t=2.03) and markedly but not significantly with age of patients (P=0.058, t=1.92).
  
  
  CONCLUSIONS
  Our findings showed that WHR, one of the important cardiovascular risk factors, can modulate independently adiponectin levels of T2DM patients in inverse manner. Also, the age of patients and HDL-C levels have marked positive effect on circulating levels of this adipocytokine. Thus, adiponectin might be a useful biomarker to prevent developing CVD in type 2 diabetes.
authors.affiliation: Nutrition and Biochemistry Department, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Javad Hosseinzadeh
authors.initials: MJ
authors.lastname: Attar
authors.forename: Somayeh
authors.initials: S
authors.lastname: Mohammadi
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Karimi
authors.forename: Arash
authors.initials: A
authors.lastname: Hosseinnezhad
authors.forename: Seyed Hossein
authors.initials: SH
authors.lastname: Hosseini
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Eshraghian
authors.forename: Nazila
authors.initials: N
authors.lastname: Jafari
authors.forename: Mazaher
authors.initials: M
authors.lastname: Rahmani
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Karimi
authors.forename: Mohammad Kamali
authors.initials: MK
authors.lastname: Nezhad
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D015930:Diet Records; D005215:Fasting; D005247:Feeding Behavior; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D007492:Iran / Q000453:epidemiology; D008297:Male; D009765:Obesity / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human