title: Focus issue: From genomic mutations to oncogenic pathways.
abstract: This two-issue series focuses on how understanding how signaling pathways are altered in cancer cells can enable researchers to develop more effective therapies. Cancer is a pleiotropic disease. Tumor cells change over time and, even within a specific tumor, cells may have different mutations and dependencies on different signaling pathways for survival or for metastatic potential. New tools and technologies for genomic- or systems-level analysis, as well as conventional biochemistry and cell biology approaches, are revealing how signaling pathways contribute to cancer development, cancer evolution, and drug resistance.
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Gough
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy; D015398:Signal Transduction / Q000235:genetics*