title: Determination of 30 synthetic food additives in soft drinks by HPLC/electrospray ionization-tandem mass spectrometry.
abstract: A method combining SPE with HPLC/electrospray ionization-MS/MS was developed for simultaneous determination of 30 synthetic food additives, including synthetic colorants, preservatives, and sweeteners in soft drinks. All targets were efficiently separated using the optimized chromatographic and MS conditions and parameters in a single run within 18 min. The LOD of the analytes ranged from 0.01 to 20 microg/kg, and the method was validated with recoveries in the 80.8 to 106.4% range. This multisynthetic additive method was found to be accurate and reliable and will be useful to ensure the safety of food products, such as the labeling and proper use of synthetic food additives in soft drinks.
authors.affiliation: Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100123, People's Republic of China Shandong Agricultural University, Tai'an 271018, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.forename: Minli
authors.initials: M
authors.lastname: Yang
authors.forename: Minglin
authors.initials: M
authors.lastname: Wang
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ya
authors.initials: Y
authors.lastname: Cao
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Chu
mesh_terms: D002253:Carbonated Beverages / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005503:Food Additives / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D005503:Food Additives