title: Factors affecting the decision to undergo risk-reducing salpingo-oophorectomy among women with BRCA gene mutation.
abstract: The objective of this study was to identify factors that affect the decision to undergo risk-reducing salpingo-oophorectomy (RRSO) in BRCA1 or BRCA2 mutations carriers in South Korea. The medical records of 124 women who had been found to have BRCA1 or BRCA2 gene mutation at our institution between May 2003 and December 2011 were reviewed. The carriers were divided into RRSO and non-RRSO groups for comparison of their clinicopathologic, socio-economic, and psychosocial factors. Of the 71 carriers eligible for RRSO, 21 had undergone RRSO. In univariate analysis, classification of carriers into 3 groups by decade of life (4th, 5th, or 6th and later decade) and subsequent analysis revealed that 52.6% of carriers in the 5th decade had undergone RRSO, a rate significantly higher than that of the other age groups (p = 0.007). The RRSO rate was higher in carriers with a personal history of breast cancer than in those without (39.2% vs. 5.0%, p = 0.004), in carriers with a family history of breast cancer than in those without (35.5% vs. 11.8%, p = 0.065), and in carriers with a family history of ovarian cancer than in those carriers without a family history (66.7% vs. 24.2%, p = 0.016). Multivariate analysis identified age and personal history of breast cancer as independent factors affecting the decision to undergo RRSO. Age and personal history of breast cancer are important factors in the decision to undergo, and should thus be considered when counseling BRCA1/2 mutation carriers.
authors.affiliation: Department of Surgery, Seoul National University Bundang Hospital, 300 Gumidong, Bundanggu, Seongnamsi, Gyeonggido, 463-707, Korea.
authors.forename: Dongwon
authors.initials: D
authors.lastname: Kim
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Kang
authors.forename: Euijun
authors.initials: E
authors.lastname: Hwang
authors.forename: Young
authors.initials: Y
authors.lastname: Sun
authors.forename: Yoonsun
authors.initials: Y
authors.lastname: Hwang
authors.forename: Cha Kyong
authors.initials: CK
authors.lastname: Yom
authors.forename: Kidong
authors.initials: K
authors.lastname: Kim
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: No
authors.forename: Yong-Beom
authors.initials: YB
authors.lastname: Kim
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics / Q000523:psychology / Q000601:surgery*; D003657:Decision Making; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000523:psychology / Q000601:surgery*; D010052:Ovariectomy / Q000706:statistics & numerical data*; D011379:Prognosis; D012307:Risk Factors; D040242:Risk Reduction Behavior; D058994:Salpingectomy / Q000706:statistics & numerical data*
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human