title: Mean central corneal thickness and corneal power measurements in pigmented and white rabbits using Visante optical coherence tomography and ATLAS corneal topography.
abstract: OBJECTIVE
  To document central corneal thickness (CCT) and power measurements in pigmented and white rabbits using Visante anterior segment optical coherence tomography (AS-OCT) and the Humphrey ATLAS Corneal Topography System (HACTS).
  
  
  METHODS
  Fourteen female rabbits (seven pigmented and seven white rabbits) were involved in this study.
  
  
  METHODS
  Twenty-eight eyes underwent AS-OCT and HACTS examination. Central corneal thickness, corneal power in the steepest and flattest meridians, astigmatism, pupil diameter (PD), and white-to-white (WTW) were calculated.
  
  
  RESULTS
  The CCT was 390 ± 14.2 and 373 ± 7.2 μm for pigmented and white rabbits, respectively. The CCT values showed statistical difference between the two breeds (P = 0.017). The corneal power in the steepest meridian was 44.6 ± 1.9 Diopter (D) in pigmented rabbits and 47.8 ± 1.5 D in white rabbits. The corneal power in the flattest meridian was 44.0 ± 2.1 D in pigmented rabbits and 47.4 ± 1.5 D in white rabbits. The astigmatism, PD, and WTW values were 0.6 ± 0.22 D, 7.9 ± 0.9, and 14.5 ± 0.1 mm in pigmented rabbits, respectively. The corresponding values in white rabbits were 0.4 ± 0.23 D, 7.5 ± 0.5, and 13.5 ± 0.2 mm. There was a statistically significant difference in corneal power in the steepest and flattest meridians and for WTW. No such difference was observed for astigmatism or PD between them.
  
  
  CONCLUSIONS
  Differences exist in the CCT, corneal power, and WTW between 5-month-old pigmented and white rabbits. Such difference should be considered when designing cornea-related experiments in rabbits.
authors.affiliation: Department of Ophthalmology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, No. 600 Yishan Road, Shanghai, 200233, China.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000818:Animals; D003315:Cornea / Q000033:anatomy & histology* / Q000502:physiology*; D005260:Female; D010860:Pigments, Biological; D011817:Rabbits; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods / Q000662:veterinary*
chemical_list: D010860:Pigments, Biological
keywords: cornea; corneal topographer; optical coherence tomography; pigmented rabbit; white rabbit