title: Passive tumor targeting of renal-clearable luminescent gold nanoparticles: long tumor retention and fast normal tissue clearance.
abstract: Glutathione-coated luminescent gold nanoparticles (GS-AuNPs) with diameters of ∼2.5 nm behave like small dye molecules (IRDye 800CW) in physiological stability and renal clearance but exhibit a much longer tumor retention time and faster normal tissue clearance, indicating that the well-known enhanced permeability and retention effect, a unique strength of conventional NPs in tumor targeting, still exists in such small NPs. These merits enable the AuNPs to detect tumor more rapidly than the dye molecules without severe accumulation in reticuloendothelial system organs, making them very promising for cancer diagnosis and therapy.
authors.affiliation: Department of Chemistry, The University of Texas at Dallas , Richardson, Texas 75080, United States.
authors.forename: Jinbin
authors.initials: J
authors.lastname: Liu
authors.forename: Mengxiao
authors.initials: M
authors.lastname: Yu
authors.forename: Chen
authors.initials: C
authors.lastname: Zhou
authors.forename: Shengyang
authors.initials: S
authors.lastname: Yang
authors.forename: Xuhui
authors.initials: X
authors.lastname: Ning
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001682:Biological Availability; D001943:Breast Neoplasms / Q000175:diagnosis; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry*; D005919:Glomerular Filtration Rate; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D014018:Tissue Distribution
chemical_list: D005456:Fluorescent Dyes; D006046:Gold