title: Do psychosis prodrome onset negative symptoms predict first presentation negative symptoms?
abstract: BACKGROUND
  Negative symptoms have been previously reported during the psychosis prodrome, however our understanding of their relationship with treatment-phase negative symptoms remains unclear.
  
  
  OBJECTIVE
  We report the prevalence of psychosis prodrome onset negative symptoms (PONS) and ascertain whether these predict negative symptoms at first presentation for treatment.
  
  
  METHODS
  Presence of expressivity or experiential negative symptom domains was established at first presentation for treatment using the Scale for Assessment of Negative Symptoms (SANS) in 373 individuals with a first episode psychosis. PONS were established using the Beiser Scale. The relationship between PONS and negative symptoms at first presentation was ascertained and regression analyses determined the relationship independent of confounding.
  
  
  RESULTS
  PONS prevalence was 50.3% in the schizophrenia spectrum group (n=155) and 31.2% in the non-schizophrenia spectrum group (n=218). In the schizophrenia spectrum group, PONS had a significant unadjusted (χ(2)=10.41, P<0.001) and adjusted (OR=2.40, 95% CI=1.11-5.22, P=0.027) association with first presentation experiential symptoms, however this relationship was not evident in the non-schizophrenia spectrum group. PONS did not predict expressivity symptoms in either diagnostic group.
  
  
  CONCLUSIONS
  PONS are common in schizophrenia spectrum diagnoses, and predict experiential symptoms at first presentation. Further prospective research is needed to examine whether negative symptoms commence during the psychosis prodrome.
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland; College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: johnlyne@mail.com.
authors.forename: J
authors.initials: J
authors.lastname: Lyne
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland; College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: L
authors.initials: L
authors.lastname: Renwick
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland.
authors.forename: K
authors.initials: K
authors.lastname: Madigan
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland; College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: B
authors.initials: B
authors.lastname: O'Donoghue
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Bonar
authors.affiliation: Centre for Support and Training in Analysis and Research (CSTAR), University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: T
authors.initials: T
authors.lastname: Grant
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland.
authors.forename: A
authors.initials: A
authors.lastname: Kinsella
authors.affiliation: Department of Psychiatry, Psychotherapy and Mental Health Research, St. Vincent's University Hospital / School of Medicine and Medical Science, University College Dublin, Elm Park, Dublin 4, Ireland.
authors.forename: K
authors.initials: K
authors.lastname: Malone
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland.
authors.forename: N
authors.initials: N
authors.lastname: Turner
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; St. John of God Community Services Ltd., Blackrock, Co., Dublin, Ireland.
authors.forename: E
authors.initials: E
authors.lastname: O'Callaghan
authors.affiliation: Dublin and East Treatment and Early Care Team (DETECT) Services, Blackrock Co., Dublin, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; St. John of God Community Services Ltd., Blackrock, Co., Dublin, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Clarke
mesh_terms: D000328:Adult; D017668:Age of Onset; D005260:Female; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D062706:Prodromal Symptoms; D011379:Prognosis; D011618:Psychotic Disorders / Q000453:epidemiology / Q000503:physiopathology*; D012559:Schizophrenia / Q000453:epidemiology / Q000503:physiopathology*
keywords: Experiential; Expressivity; Negative symptoms; Psychosis prodrome; Schizophrenia