title: The effect of low-dose aspirin treatment on biochemical markers in pregnant hypertensive patients.
abstract: We evaluated the known metabolic effects of aspirin in pregnant hypertensive patients. Eighty-seven pregnant women (12th-24th gestational week) were randomly allocated to low-dose aspirin or placebo treatment. Between the 24th-28th gestational week the following tests were performed: oral glucose tolerance test, venous blood pH and base excess, coagulation profile, platelet count, morning (8 a.m.) cortisol, creatinine clearance and serum uric acid. A significantly higher serum uric acid level was detected in the low-dose aspirin group (5.6±2.2 mg/dl) compared with the placebo group (4.7±1.2 mg/dl, p=0.048). No other significant difference was found for any of the other parameters tested. We conclude that low-dose aspirin treatment during the second half of pregnancy in hypertensive patients seems safe in terms of its effect on various maternal metabolic effects.
authors.affiliation: Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Bar
authors.forename: D
authors.initials: D
authors.lastname: Rabinerson
authors.forename: A
authors.initials: A
authors.lastname: Padoa
authors.forename: Z
authors.initials: Z
authors.lastname: Nitzan
authors.forename: A
authors.initials: A
authors.lastname: Neri
authors.forename: B
authors.initials: B
authors.lastname: Fisch
authors.forename: M
authors.initials: M
authors.lastname: Hod