title: Role of plasmacytoid dendritic cells in breast cancer bone dissemination.
abstract: Elevated levels of plasmacytoid dendritic cells (pDC) have been observed as breast cancer disseminates to the bone. The selective depletion of pDC in mice led to a total abrogation of bone metastasis as well as to an increase in TH1 antitumor response, suggesting that pDC may be considered as a potential therapeutic target for metastatic breast cancer.
authors.affiliation: Department of Pathology; The University of Alabama at Birmingham; Birmingham, AL USA.
authors.forename: Anandi
authors.initials: A
authors.lastname: Sawant
authors.forename: Selvarangan
authors.initials: S
authors.lastname: Ponnazhagan
keywords: bone metastasis; breast cancer; osteoclasts; plasmacytoid dendritic cells