title: A 12-membered to a strained 11-membered ring: first stereoselective total synthesis of (-)-asteriscunolide C.
abstract: The first stereoselective total synthesis of (-)-asteriscunolide C has been accomplished in 12 steps in a 16% overall yield. The key step is the conversion of a 12-membered to a strained 11-membered ring with one Z- and two E-double bonds employing a late stage ring-closing metathesis.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, Maharashtra, India. rfernand@chem.iitb.ac.in
authors.forename: Rodney A
authors.initials: RA
authors.lastname: Fernandes
authors.forename: Vijay P
authors.initials: VP
authors.lastname: Chavan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D007783:Lactones; D012717:Sesquiterpenes