title: Phenotypic vs. target-based drug discovery for first-in-class medicines.
abstract: Current drug discovery strategies include both molecular and empirical approaches. The molecular approaches are predominantly hypothesis-driven and are referred to as target-based. The empirical approaches are referred to as phenotypic because they rely on phenotypic measures of response. A recent analysis revealed the phenotypic approaches to be the more successful strategy for small-molecule, first-in-class medicines. The rationalization for this success was the unbiased identification of the molecular mechanism of action (MMOA).
authors.affiliation: Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, California, USA. david.swinney@irnd3.org
authors.forename: D C
authors.initials: DC
authors.lastname: Swinney
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*