title: ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis.
abstract: The ADAM and ADAMTS families, also called adamalysins belong to an important group of extracellular matrix proteins. The ADAMs family belong to both the transmembrane and secreted proteins, while ADAMTS family only contains secreted forms. Adamalysins play an important role in the cell phenotype regulation via their activities in signaling pathways, cell adhesion and migration. The human proteome contains 21 ADAM, and 19 ADAMTS proteins, which are involved in extracellular matrix remodeling, shedding of various substrates such as: adhesion ligands, growth factors, their receptors and diverse cytokines. Recent studies provide evidence that adamalysins play a crucial role in colorectal cancer (CRC) etiopathogenesis. It seems possible that adamalysins might be used as CRC prediction markers or potential pharmaceutical targets.
authors.affiliation: Department of Genetics, Wroclaw Medical University, Wroclaw, Poland. przemyslaw.leszczynski@am.wroc.pl
authors.forename: Leszczynski
authors.initials: L
authors.lastname: Przemyslaw
authors.forename: Hendrich Andrzej
authors.initials: HA
authors.lastname: Boguslaw
authors.forename: Szmida
authors.initials: S
authors.lastname: Elzbieta
authors.forename: Sasiadek Maria
authors.initials: SM
authors.lastname: Malgorzata
mesh_terms: D051722:ADAM Proteins / Q000502:physiology*; D015179:Colorectal Neoplasms / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*
chemical_list: D051722:ADAM Proteins; D046988:Proteasome Endopeptidase Complex