title: Pediatric Acute Kidney Injury: Different From Acute Renal Failure But How And Why.
abstract: Acute kidney injury [AKI] refers to a clinical syndrome encompassing various etiologies and occurring in a variety of clinical settings, with manifestations ranging from subtle biochemical and structural changes, to minimal elevation in serum creatinine, to anuric renal failure. Understanding the spectrum of AKI and the importance of the early pre-clinical damage stage has resulted in an improved ability to define and stage pediatric AKI, to understand the AKI-to-CKD transition, and harness novel damage biomarkers to predict AKI and its adverse outcomes. These concepts are expanded upon in this review, with an emphasis on publications from the past three years.
authors.affiliation: Center for Acute Care Nephrology, Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH 45229-3039. Phone: [513] 636-4531. Fax: [513] 636-7407. prasad.devarajan@cchmc.org.
authors.forename: Prasad
authors.initials: P
authors.lastname: Devarajan
keywords: acute kidney injury; acute renal failure; biomarkers; neutrophil gelatinase-associated liopcalin