title: Long-term treatment of hypogonadal men with testosterone produces substantial and sustained weight loss.
abstract: OBJECTIVE
  This study analyzed the effects of normalization of serum testosterone (T) levels on anthropometric parameters in hypogonadal men.
  
  
  METHODS
  Open-label, single-center, cumulative, prospective registry study of 255 men (aged 33-69 years, mean 58.02 ± 6.30 years), with T levels below 12.13 nmol/L (mean: 9.93±1.38). 215 men for at least 2 years, 182 for 3 years, 148 for 4, and 116 for at least 5 years were studied. They received parenteral T undecanoate 1,000 mg/12 weeks after an initial interval of 6 weeks.
  
  
  RESULTS
  Body weight (BW) decreased from 106.22 ± 16.93 kg to 90.07 ± 9.51 kg. Waist circumference (WC) reduced from 107.24 ± 9.14 cm to 98.46 ± 7.39 cm. BMI (m/kg(2) ) declined from 33.9 ± 5.51 m/kg(2) to 29.13 ± 3.09 m/kg(2) . All parameters examined were statistically significant with P < 0.0001 versus baseline and versus the previous year over 5 years indicating a continuous weight loss over the full observation period. The mean per cent weight loss after 1 year was 4.16 ± 0.31%, after 2 years 7.54 ± 0.32%, after 3 years 9.23 ± 0.33%, after 4 years 11.42 ± 0.35% and after 5 years 13.57 ± 0.37%.
  
  
  CONCLUSIONS
  In an uncontrolled, observational cohort, normalizing serum T to normal physiological levels produced consistent loss of BW, WC, and BMI. These improvements were progressive over the full 5 years of the study.
authors.affiliation: Bayer Pharma, Global Medical Affairs Andrology, Berlin, Germany and Gulf Medical University School of Medicine, Ajman, UAE.
authors.forename: Farid
authors.initials: F
authors.lastname: Saad
authors.forename: Ahmad
authors.initials: A
authors.lastname: Haider
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Doros
authors.forename: Abdulmaged
authors.initials: A
authors.lastname: Traish
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005500:Follow-Up Studies; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013739:Testosterone / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D055105:Waist Circumference / Q000187:drug effects*; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D013739:Testosterone; C010792:testosterone undecanoate