title: The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.
abstract: Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
authors.affiliation: Department of Oncological Sciences, Mount Sinai Medical School, New York, NY 10029, USA. Miriam.merad@mssm.edu
authors.forename: Miriam
authors.initials: M
authors.lastname: Merad
authors.forename: Priyanka
authors.initials: P
authors.lastname: Sathe
authors.forename: Julie
authors.initials: J
authors.lastname: Helft
authors.forename: Jennifer
authors.initials: J
authors.lastname: Miller
authors.forename: Arthur
authors.initials: A
authors.lastname: Mortha
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000502:physiology; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology / Q000473:pathology
chemical_list: D018836:Inflammation Mediators