title: Caveolin-1 as a promoter of tumour spreading: when, how, where and why.
abstract: Caveolae are non-clathrin invaginations of the plasma membrane in most cell types; they are involved in signalling functions and molecule trafficking, thus modulating several biological functions, including cell growth, apoptosis and angiogenesis. The major structural protein in caveolae is caveolin-1, which is known to act as a key regulator in cancer onset and progression through its role as a tumour suppressor. Caveolin-1 can also promote cell proliferation, survival and metastasis as well as chemo- and radioresistance. Here, we discuss recent findings and novel concepts that support a role for caveolin-1 in cancer development and its distant spreading. We also address the potential application of caveolin-1 in tumour therapy and diagnosis.
authors.affiliation: Department of Medical Sciences, University of Turin, Turin, Italy.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Senetta
authors.forename: Giulia
authors.initials: G
authors.lastname: Stella
authors.forename: Ernesto
authors.initials: E
authors.lastname: Pozzi
authors.forename: Niccolo
authors.initials: N
authors.lastname: Sturli
authors.forename: Daniela
authors.initials: D
authors.lastname: Massi
authors.forename: Paola
authors.initials: P
authors.lastname: Cassoni
mesh_terms: D000818:Animals; D051242:Caveolin 1 / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D051242:Caveolin 1