title: Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones.
abstract: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in cancer cells over normal cells; however, tumor cells may develop TRAIL resistance. Here, we demonstrate that this resistance can be overcome in the presence of bacterial acylhomoserine lactones (AHLs) or AHL-producing bacteria through the combined effect of TRAIL-induced apoptosis and AHL-mediated inhibition of inflammation regulated by NF-κB signaling. This discovery unveils a previously unrecognized symbiotic link between bacteria and host immunosurveillance.
authors.affiliation: Department of Immunology and Microbial Sciences and ‡Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kravchenko
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Garner
authors.forename: John
authors.initials: J
authors.lastname: Mathison
authors.forename: Alim
authors.initials: A
authors.lastname: Seit-Nebi
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.forename: Irina P
authors.initials: IP
authors.lastname: Gileva
authors.forename: Richard
authors.initials: R
authors.lastname: Ulevitch
authors.forename: Kim D
authors.initials: KD
authors.lastname: Janda
mesh_terms: D054742:Acyl-Butyrolactones / Q000737:chemistry / Q000276:immunology*; D017209:Apoptosis; D045744:Cell Line, Tumor; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D016328:NF-kappa B / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000737:chemistry / Q000276:immunology*; D015398:Signal Transduction; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000276:immunology
chemical_list: D054742:Acyl-Butyrolactones; D016207:Cytokines; D016328:NF-kappa B; D053221:TNF-Related Apoptosis-Inducing Ligand