title: Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study.
abstract: OBJECTIVE
  There are many studies demonstrating deteriorated ventricle and endothelium functions in familial Mediterranean fever (FMF) patients. As FMF is an autoinflammatory disease with an ongoing inflammatory activity and inflammation plays an important role in the development and progression of atherosclerosis in some of the rheumatic diseases, we aimed to investigate the early markers of atherosclerosis in patients with FMF by the measurements of serum paraoxonase-1 (PON-1) activity, mean platelet volume (MPV) and malondialdehyde (MDA) level.
  
  
  METHODS
  This study is a cross-sectional, observational study. Forty consecutive patients with FMF and twenty healthy volunteers were selected to form the study population. The diagnosis of FMF was based on Tel-Hashomer criteria. Serum PON-1 activity, MPV and MDA level were determined to examine their association with FMF. Student's t-test, Mann-Whitney U test, Pearson correlation analysis were used for statistical analysis.
  
  
  RESULTS
  The mean PON-1 activity in FMF patients was significantly lower than in the healthy population (141.46±38.29 vs. 179.62±10.73 U/l, p<0.01). Serum MDA levels were the same between the groups (1.08±0.66 vs. 1.08±0.33 nmol/mL, p=0.99). MPV was higher in FMF patients than in the control l group (8.87±0.99 vs. 8.22±0.45 fl, p=0.04). PON, MPV and MDA levels were the same in FMF patients with acute attack and attack -free period.
  
  
  CONCLUSIONS
  Our results show that PON-1 activity is lower in patients with FMF. Reduced PON-1 activity and increased MPV, independent of the oxidative stress status of these patients, may lead to increased atherosclerotic propensity in FMF.
authors.affiliation: Clinic of Cardiology, Balıkesir State Hospital, Balıkesir-Turkey. ozlemkarakurt55@yahoo.com
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Karakurt Arıtürk
authors.forename: Kemal
authors.initials: K
authors.lastname: Üreten
authors.forename: Münevver
authors.initials: M
authors.lastname: Sarı
authors.forename: Nuray
authors.initials: N
authors.lastname: Yazıhan
authors.forename: Ezgi
authors.initials: E
authors.lastname: Ermiş
authors.forename: İmge
authors.initials: İ
authors.lastname: Ergüder
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D001792:Blood Platelets / Q000166:cytology*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D010505:Familial Mediterranean Fever / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D010976:Platelet Count; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D008315:Malondialdehyde; D002784:Cholesterol; D043303:Aryldialkylphosphatase