title: Gold nanorods mediated controlled release of doxorubicin: nano-needles for efficient drug delivery.
abstract: Use of cysteamine hydrochloride (Cys-HCl) protected gold nanorods (GNRs) as efficient carrier of widely used anti-cancer drug doxorubicin using folic acid as navigational molecule is presented in this work. GNRs were found to have excellent drug loading capacity of >97 %. A detailed comprehension of in vitro drug release profile under ideal physiological condition was found to obey 1st order kinetics at pH 6.8, 5.3 and 7.2, an ideal milieu for drug delivery to solid tumours.
authors.affiliation: N. S. N. Research Centre for Nanotechnology and Bionanotechnology, Jambhul Phata, Ambernath (W), 421 505, Maharashtra, India. gurus.spandey@gmail.com
authors.forename: Sunil
authors.initials: S
authors.lastname: Pandey
authors.forename: Ritu
authors.initials: R
authors.lastname: Shah
authors.forename: Ashmi
authors.initials: A
authors.lastname: Mewada
authors.forename: Mukeshchand
authors.initials: M
authors.lastname: Thakur
authors.forename: Goldie
authors.initials: G
authors.lastname: Oza
authors.forename: Madhuri
authors.initials: M
authors.lastname: Sharon
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000295:instrumentation; D004526:Efficiency; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D036103:Nanotechnology / Q000379:methods; D043942:Nanotubes / Q000737:chemistry*; D009339:Needles; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006046:Gold; D004317:Doxorubicin