title: [Delay in leprosy diagnosis as a predictor of disability in a cohort of patients in Colombia, 2000-2010].
abstract: OBJECTIVE
  Evaluate predictive factors of disability at time of leprosy diagnosis in a cohort of Colombian patients, from 2000 to 2010.
  
  
  METHODS
  Descriptive and analytical observational study of a retrospective cohort of patients admitted with a leprosy diagnosis to the Centro Dermatológico Federico Lleras Acosta in Bogotá, Colombia, from 2000 to 2010. Variables were analyzed descriptively and predictive factors for disability at diagnosis were identified through simple and multifactorial analyses (Cox proportional hazards model); hazard ratios for each factor in the model were calculated.
  
  
  RESULTS
  Time between first symptoms and diagnosis in the 333 cohort patients was 2.9 years on average; 32.3% had certain degree of disability, especially for the feet. Delay in diagnosis and disability was greater in men than in women and in patients with multibacillary rather than paucibacillary leprosy. Disability was significantly associated with delays of ≥ 1 year in diagnosis, age ≥ 30 years, initial bacillary index of ≥ 2, multibacillary leprosy, and natives of the Cundinamarca or Santander departments. Protective factors were female sex, having some education, and residence in Boyacá.
  
  
  CONCLUSIONS
  Time between first symptoms and diagnosis is the key predictive factor of disability at time of leprosy diagnosis. Strengthening of active searching for infected people and promotion of early diagnosis are recommended.
authors.affiliation: Instituto Nacional de Dermatología, Centro Dermatológico Federico Lleras Acosta, Bogotá, D.C., Colombia. marthainiridag@yahoo.com
authors.forename: Martha Inírida
authors.initials: MI
authors.lastname: Guerrero
authors.forename: Sandra
authors.initials: S
authors.lastname: Muvdi
authors.forename: Clara Inés
authors.initials: CI
authors.lastname: León
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015331:Cohort Studies; D003105:Colombia; D057210:Delayed Diagnosis / Q000009:adverse effects*; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D007918:Leprosy / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult