title: [Locally advanced squamous cell carcinoma of the buttocks, which had complete remission induced by chemoradiotherapy with carboplatin].
abstract: The patient was a 72-year-old male who had locally advanced squamous cell carcinoma(10×7 cm)in his buttocks that developed 18 months prior to admission. The lesion was unresectable because of the size and its invasion to the sacrum. We performed concomitant chemoradiotherapy with curative intent. External beam radiotherapy(68 Gy)was given with weekly carboplatin(AUC 2)and paclitaxel(30mg/m2). Because he developed cellulites in the irradiated skin, the concurrent chemotherapy was stopped during treatment(at 10 Gy). After improvement of the cellulites, paclitaxel was switched to S-1(80 mg/body/day)and concurrent chemoradiotherapy was completed without further toxicities. Progression of the tumor outside the irradiated field was seen 4 months after the treatment. Four courses of carboplatin (AUC 5)+infusional 5-FU(1, 000mg/m2 day 1-4)was administered as the tumor regressed. He died of sepsis 36 months post-treatment but the tumor remained stable without progression. Chemoradiotherapy may be an option for locally advanced non-melanoma skin cancer.
authors.affiliation: Dept. of Medical Oncology, Kameda Medical Center, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mikawa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Koyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Gomi
authors.forename: Koji
authors.initials: K
authors.lastname: Nagura
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsuda
authors.forename: Reiko
authors.initials: R
authors.lastname: Seki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanaka
authors.forename: Kazutora
authors.initials: K
authors.lastname: Shoji
authors.forename: Yu
authors.initials: Y
authors.lastname: Oyama
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D006615:Hip / Q000473:pathology*; D006801:Humans; D008297:Male; D012074:Remission Induction; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin