title: Total synthesis of the big four antibiotics and related antibiotics.
abstract: The first total syntheses of a variety of antibiotics have been accomplished by using carbohydrates as a chiral source. The key target molecules were members of the 'Big Four' classes of antibiotics (macrolides, aminoglycosides, β-lactams and tetracyclines), naphthoquinone antibiotics and their related antibiotics.
authors.affiliation: Research Institute for Science and Engineering, Waseda University, Tokyo, Japan. tatsuta@waseda.jp
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Tatsuta
mesh_terms: D000617:Aminoglycosides / Q000138:chemical synthesis / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry; D013754:Tetracyclines / Q000138:chemical synthesis / Q000737:chemistry; D047090:beta-Lactams / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001688:Biological Products; D002241:Carbohydrates; D018942:Macrolides; D009285:Naphthoquinones; D013754:Tetracyclines; D047090:beta-Lactams