title: Apolipoprotein L1 risk variants associate with systemic lupus erythematosus-associated collapsing glomerulopathy.
abstract: Collapsing glomerulopathy is a devastating renal disease that primarily affects African Americans and associates with numerous etiologies, such as HIV and autoimmune disease. The presence of APOL1 risk alleles associates with HIV-associated collapsing glomerulopathy, but it is unknown whether these risk alleles also associate with systemic lupus erythematosus (SLE) -associated collapsing glomerulopathy. Here, re-examination of 546 renal biopsies from African-American patients with SLE identified 26 cases of collapsing glomerulopathy, which we genotyped for APOL1 risk alleles using DNA extracted from archived biopsy tissue. APOL1 strongly associated with SLE-associated collapsing glomerulopathy (P<0.001). In a recessive model, two APOL1 risk alleles conferred 5.4-fold (95% CI=2.4 to 12.1) higher odds of developing SLE-associated collapsing glomerulopathy (P<0.001). In conclusion, APOL1 genotyping of African-American patients with SLE might help identify patients at risk for collapsing glomerulopathy, an entity with a poor prognosis that is often resistant to treatment.
authors.affiliation: Nephropath, 10810 Executive Center Drive, Suite 100, Little Rock, AR 72211, USA. chris.larsen@nephropath.com
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Larsen
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: Beggs
authors.forename: Mohammad
authors.initials: M
authors.lastname: Saeed
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Walker
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000483:Alleles; D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000235:genetics* / Q000502:physiology; D015331:Cohort Studies; D005838:Genotype; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D008075:Lipoproteins, HDL / Q000235:genetics* / Q000502:physiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008181:Lupus Nephritis / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D012306:Risk
chemical_list: C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL