title: Epidemiology of head and neck squamous cell carcinoma not related to tobacco or alcohol.
abstract: OBJECTIVE
  This review intends to present some epidemiological findings regarding the epidemiology of head and neck squamous cell carcinoma not related to alcohol or tobacco (HNSCCNAT).
  
  
  RESULTS
  Twenty-five percent of squamous cell carcinomas of head and neck are not related to tobacco or alcohol consumption. The risk factors for this group of malignancies are not very well established yet. HNSCCNAT are more likely to occur in the oropharynx. The diagnosis is more frequent at young age (before 50). The prevalence of human papillomavirus (HPV-positive) infection is high.
  
  
  CONCLUSIONS
  Monitoring HPV status in head and neck cancer patients who are not tobacco or alcohol consumers will enable physicians to better plan treatment.
authors.affiliation: International Prevention Research Institute, Ecully, France. maria-paula.curado@i-pri.org
authors.forename: Maria P
authors.initials: MP
authors.lastname: Curado
authors.forename: Peter
authors.initials: P
authors.lastname: Boyle
mesh_terms: D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking / Q000453:epidemiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000821:virology; D005260:Female; D014943:Global Health / Q000706:statistics & numerical data; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000453:epidemiology; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology*; D000077195:Squamous Cell Carcinoma of Head and Neck