title: Combination delivery of antigens and CpG by lanthanides-based core-shell nanoparticles for enhanced immune response and dual-mode imaging.
abstract: Europium-doped GdPO4 hollow spheres/polymer core-shell nanoparticles are functionalized with ovalbumin (OVA) as a model antigen and an oligonucleotide (CpG) that stimulates the immune response. These functionalized core-shell nanoparticles are used as vaccines, where they enable efficient delivery of an antigen to target sites, tracking of the vaccines using non-invasive clinical imaging technology.
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Meili
authors.initials: M
authors.lastname: Yin
authors.forename: Xinjian
authors.initials: X
authors.lastname: Yang
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000276:immunology; D000941:Antigens / Q000737:chemistry* / Q000276:immunology; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry; D018899:CpG Islands; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005682:Gadolinium / Q000737:chemistry; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000000981:diagnostic imaging; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D010047:Ovalbumin / Q000737:chemistry / Q000276:immunology; D011859:Radiography
chemical_list: D000906:Antibodies; D000941:Antigens; D056831:Coordination Complexes; D016207:Cytokines; D028581:Lanthanoid Series Elements; D009838:Oligodeoxyribonucleotides; D010047:Ovalbumin; D005682:Gadolinium
keywords: CpG ODN; antigens; co-delivery; dual-mode imaging; immune