title: How quantitative differences in dendritic cell maturation can direct TH1/TH2-cell polarization.
abstract: The polarization of TH1 or TH2 responses by dendritic cells (DCs) requires distinct maturation conditions. Our data indicate that quantitative differences in DC maturation dictate a TH1or TH2-cell polarization outcome. We discuss how chromatin remodeling at DC loci coding for pro-inflammatory vs. polarizing cytokines may explain differential TH-cell polarization.
authors.affiliation: Institute of Virology and Immunobiology; University of Würzburg; Würzburg, Germany.
authors.forename: Manfred B
authors.initials: MB
authors.lastname: Lutz
keywords: HDAC; TH2; chromatin; cytokines; dendritic cells; epigenetic; histone; polarization