title: Vinylic amino group activation: a new and general strategy leading to functionalized fused heteroaromatics.
abstract: A conceptually new and general strategy has been developed for the construction of a benzimidazole or a benzoxazole ring fused with isoquinolinone affording a diverse and unique class of small molecules as potential and novel inhibitors of PDE4.
authors.affiliation: Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India.
authors.forename: Rajnikanth
authors.initials: R
authors.lastname: Sunke
authors.forename: Raju
authors.initials: R
authors.lastname: Adepu
authors.forename: Ravikumar
authors.initials: R
authors.lastname: Kapavarapu
authors.forename: Swetha
authors.initials: S
authors.lastname: Chintala
authors.forename: Chandana Lakshmi Teja
authors.initials: CL
authors.lastname: Meda
authors.forename: Kishore V L
authors.initials: KV
authors.lastname: Parsa
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry*; D001583:Benzoxazoles / Q000737:chemistry*; D003500:Cyclization; D007475:Ion Exchange Resins / Q000737:chemistry; D007546:Isoquinolines / Q000737:chemistry*; D058988:Phosphodiesterase 4 Inhibitors / Q000737:chemistry*; D013343:Styrenes / Q000737:chemistry
chemical_list: D001562:Benzimidazoles; D001583:Benzoxazoles; D007475:Ion Exchange Resins; D007546:Isoquinolines; D058988:Phosphodiesterase 4 Inhibitors; D013343:Styrenes; C528218:amberlyst-15; C031000:benzimidazole