title: Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.
abstract: The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.
authors.affiliation: Laboratory of Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece. gepsomas@chem.auth.gr
authors.forename: George
authors.initials: G
authors.lastname: Psomas
authors.forename: Dimitris P
authors.initials: DP
authors.lastname: Kessissoglou
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D006801:Humans; D019216:Metals, Heavy / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry; D015363:Quinolones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D015032:Zinc / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019216:Metals, Heavy; D015363:Quinolones; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc