title: Interaction of anticancer ruthenium compounds with proteins: high-resolution X-ray structures and raman microscopy studies of the adduct between hen egg white lysozyme and AziRu.
abstract: The binding properties of AziRu, a ruthenium(III) complex with high antiproliferative activity, toward a hen egg white lysozyme have been investigated by X-ray crystallography and Raman microscopy. The data provide clear evidence on the mechanism of AziRu-protein adduct formation and of ligand exchange in the crystal state.
authors.affiliation: Department of Chemical Sciences, University of Naples Federico II, Napoli, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vergara
authors.forename: Gerardino
authors.initials: G
authors.lastname: D'Errico
authors.forename: Daniela
authors.initials: D
authors.lastname: Montesarchio
authors.forename: Gaetano
authors.initials: G
authors.lastname: Mangiapia
authors.forename: Luigi
authors.initials: L
authors.lastname: Paduano
authors.forename: Antonello
authors.initials: A
authors.lastname: Merlino
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism*; D002645:Chickens; D018360:Crystallography, X-Ray; D004121:Dimethyl Sulfoxide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D008853:Microscopy; D008958:Models, Molecular; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism*; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism; D012428:Ruthenium / Q000737:chemistry / Q000378:metabolism*; D017975:Ruthenium Compounds
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D011725:Pyridines; D017975:Ruthenium Compounds; C113661:imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III); D012428:Ruthenium; C421864:hen egg lysozyme; D009113:Muramidase; D004121:Dimethyl Sulfoxide