title: Effects of selenoprotein P on the contraction and relaxation of the airway smooth muscle.
abstract: Selenoprotein P (SeP) not only represents the major selenoprotein in plasma, but also provides more than 50% of the total plasma selenium. However, there is no report concerning the direct action of selenium or selenium-containing compounds on the contraction and relaxation of the airway smooth muscle. Therefore, we investigated the effects of SeP and sodium selenite (SS) on the indirectly induced contraction and relaxation of the cat bronchi, and gel contraction of cultured bovine tracheal smooth muscle cells (BTSMC) induced by ATP. In the present results, SeP or SS suppressed the amplitude of twitch-like contractions of cat bronchiole without affecting the non-adrenergic and non-cholinergic (NANC) relaxations evoked by electrical field stimulation. SeP also suppressed the ATP-induced gel contraction of BTSMC. These results suggest that SeP suppresses the amplitude of twitch-like contraction of cat bronchiole by acting directly on the bronchiolar smooth muscle.
authors.affiliation: Research Division for Life Sciences, Kumamoto Health Science University, Kumamoto, Japan.
authors.forename: Sachie K
authors.initials: SK
authors.lastname: Ogawa
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Masaki
authors.initials: M
authors.lastname: Hirashima
authors.forename: Norio
authors.initials: N
authors.lastname: Akaike
authors.forename: Yushi
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D055745:Bronchioles / Q000378:metabolism; D002415:Cats; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D004560:Electricity; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000378:metabolism*; D032389:Myocytes, Smooth Muscle / Q000166:cytology; D012643:Selenium / Q000097:blood*; D051149:Selenoprotein P / Q000378:metabolism / Q000494:pharmacology*; D018038:Sodium Selenite / Q000494:pharmacology; D013314:Stress, Mechanical; D013997:Time Factors; D014132:Trachea / Q000378:metabolism
chemical_list: D051149:Selenoprotein P; D000255:Adenosine Triphosphate; D012643:Selenium; D018038:Sodium Selenite