title: Creatine kinase response to high-intensity aerobic exercise in adult-onset muscular dystrophy.
abstract: BACKGROUND
  We investigated the effect of high-intensity exercise on plasma creatine kinase (CK) in patients with muscular dystrophies.
  
  
  METHODS
  Fourteen patients with Becker (BMD), facioscapulohumeral (FSHD), or limb-girdle type 2 (LGMD2) muscular dystrophy, and 8 healthy subjects performed 5 cycling tests: an incremental max test, and tests at 65%, 75%, 85%, and 95% of maximal oxygen uptake (VO2max ). Heart rate and oxygen consumption were measured during the tests, and plasma CK was measured before, immediately after, and 24 hours after exercise.
  
  
  RESULTS
  All subjects were able to perform high-intensity exercise at the different levels. In patients with LGMD2 and FSHD, CK normalized 24 hours after exercise compared with the pre-exercise value, whereas those with BMD and healthy controls had elevated CK values 24 hours after exercise.
  
  
  CONCLUSIONS
  The findings suggest that high-intensity exercise is generally well tolerated in patients with LGMD2 and FSHD, whereas those with BMD may be more prone to exercise-induced damage.
authors.affiliation: Neuromuscular Research Unit, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
authors.forename: Søren P
authors.initials: SP
authors.lastname: Andersen
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Sveen
authors.forename: Regitze S
authors.initials: RS
authors.lastname: Hansen
authors.forename: Karen L
authors.initials: KL
authors.lastname: Madsen
authors.forename: Jonas B
authors.initials: JB
authors.lastname: Hansen
authors.forename: Mads
authors.initials: M
authors.lastname: Madsen
authors.forename: John
authors.initials: J
authors.lastname: Vissing
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000097:blood*; D004421:Dystonia / Q000097:blood* / Q000503:physiopathology*; D015444:Exercise; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D049288:Muscular Dystrophies, Limb-Girdle / Q000097:blood; D020391:Muscular Dystrophy, Facioscapulohumeral / Q000097:blood; D009224:Myotonia Congenita / Q000097:blood; D010101:Oxygen Consumption; D064232:Visual Analog Scale; D055815:Young Adult
chemical_list: D003402:Creatine Kinase
keywords: Becker muscular dystrophy; creatine kinase; facioscapulohumeral muscular dystrophy; limb-girdle muscular dystrophy type 2; muscular dystrophy