title: Asymmetric methallylation of ketones catalyzed by a highly active organocatalyst 3,3'-F2-BINOL.
abstract: (S)-3,3'-F2-BINOL has been synthesized for the first time and demonstrated as a highly active organocatalyst for asymmetric methallylation of ketones. Up to 98:2 enantioselectivity and 99% yield were obtained with 5 mol % catalyst loading. The catalyst (S)-3,3'-F2-BINOL could be easily recovered and reused.
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road/P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States. yongda.zhang@boehringer-ingelheim.com
authors.forename: Yongda
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Qu
authors.forename: Shengli
authors.initials: S
authors.lastname: Ma
authors.forename: Heewon
authors.initials: H
authors.lastname: Lee
authors.forename: Nina C
authors.initials: NC
authors.lastname: Gonnella
authors.forename: Joe
authors.initials: J
authors.lastname: Gao
authors.forename: Wenjie
authors.initials: W
authors.lastname: Li
authors.forename: Zhulin
authors.initials: Z
authors.lastname: Tan
authors.forename: Jonathan T
authors.initials: JT
authors.lastname: Reeves
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Jon C
authors.initials: JC
authors.lastname: Lorenz
authors.forename: Guisheng
authors.initials: G
authors.lastname: Li
authors.forename: Diana C
authors.initials: DC
authors.lastname: Reeves
authors.forename: Ajith
authors.initials: A
authors.lastname: Premasiri
authors.forename: Nelu
authors.initials: N
authors.lastname: Grinberg
authors.forename: Nizar
authors.initials: N
authors.lastname: Haddad
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Lu
authors.forename: Jinhua J
authors.initials: JJ
authors.lastname: Song
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C583118:3,3'-F2-BINOL; C406944:BINOL, naphthol; D007659:Ketones; D009284:Naphthols