title: Pelvic-ureteric junction obstruction and hypertension with target organ damage: a case report and review of the literature.
abstract: Pelvic-ureteric junction obstruction (PUJO) is rare in adults and may be seen when the diagnosis has been missed in childhood. Hypertension may be a feature of PUJO but limited data are currently available in literature to support its association. We report a case of a 29-year-old woman who presented with severe hypertension. Work-up to exclude secondary hypertension showed high plasma renin activity, and imaging by ultrasound and computerized tomography a hydronephrosis and PUJO with impairment of kidney drainage at the renal scintigraphy. After double-J ureteric stenting, blood pressure decreased, antihypertensive medication tapered and the patients was normotensive with no antihypertensive medications after 6 months. We provide an update of the pathophysiology of hypertension in PUJO and a review of the available literature in order better to define the available treatments for these patients.
authors.affiliation: Department of Medicine (DIMED), Clinica Medica 4.
authors.forename: Martino F
authors.initials: MF
authors.lastname: Pengo
authors.forename: Pietro
authors.initials: P
authors.lastname: Soloni
authors.forename: Diego
authors.initials: D
authors.lastname: Cecchin
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maiolino
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Rossi
authors.forename: Lorenzo A
authors.initials: LA
authors.lastname: Calò
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D007682:Kidney Pelvis / Q000503:physiopathology*; D009102:Multiple Organ Failure / Q000503:physiopathology; D016896:Treatment Outcome; D014517:Ureteral Obstruction / Q000503:physiopathology*