title: Inhibition of AGEs formation by natural products.
abstract: Since advanced glycation end-products (AGEs) inhibitors such as benfotiamine, pyridoxamine and aminoguanidine significantly inhibit the development of retinopathy and neuropathy in streptozotocin-induced diabetic rats, treatment with AGEs inhibitors is believed to be a potential strategy for preventing lifestyle-related diseases such as diabetic complications and atherosclerosis. Furthermore, preventive medicine is the most important approach to preventing lifestyle-related diseases, and improving daily nutritional intake is thought to prevent the pathogenesis of such diseases. Therefore, AGEs inhibitors that can be obtained from daily meals are preferred to prescribed drugs. In this article, we describe a strategy for developing new AGEs inhibitors from natural products.
authors.affiliation: Laboratory of Food and Regulation Biology Department of Bioscience, School of Agriculture, Tokai University, Kawayou Minamiaso Aso-gun, Kumamoto, 869-1404, Japan, nagai-883@umin.ac.jp.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Nagai
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Shirakawa
authors.forename: Rei-Ichi
authors.initials: R
authors.lastname: Ohno
authors.forename: Narumi
authors.initials: N
authors.lastname: Moroishi
authors.forename: Mime
authors.initials: M
authors.lastname: Nagai
mesh_terms: D000818:Animals; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D050260:Carbohydrate Metabolism / Q000187:drug effects; D048909:Diabetes Complications / Q000378:metabolism / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D001688:Biological Products; D017127:Glycation End Products, Advanced; C048496:N(6)-carboxymethyllysine; D008239:Lysine