title: Automatic segmentation of the choroid in enhanced depth imaging optical coherence tomography images.
abstract: Enhanced Depth Imaging (EDI) optical coherence tomography (OCT) provides high-definition cross-sectional images of the choroid in vivo, and hence is used in many clinical studies. However, the quantification of the choroid depends on the manual labelings of two boundaries, Bruch's membrane and the choroidal-scleral interface. This labeling process is tedious and subjective of inter-observer differences, hence, automatic segmentation of the choroid layer is highly desirable. In this paper, we present a fast and accurate algorithm that could segment the choroid automatically. Bruch's membrane is detected by searching the pixel with the biggest gradient value above the retinal pigment epithelium (RPE) and the choroidal-scleral interface is delineated by finding the shortest path of the graph formed by valley pixels using Dijkstra's algorithm. The experiments comparing automatic segmentation results with the manual labelings are conducted on 45 EDI-OCT images and the average of Dice's Coefficient is 90.5%, which shows good consistency of the algorithm with the manual labelings. The processing time for each image is about 1.25 seconds.
authors.affiliation: Nanyang Technological University, Nanyang Avenue 50, 639798 Singapore.
authors.forename: Jing
authors.initials: J
authors.lastname: Tian
authors.forename: Pina
authors.initials: P
authors.lastname: Marziliano
authors.forename: Mani
authors.initials: M
authors.lastname: Baskaran
authors.forename: Tin Aung
authors.initials: TA
authors.lastname: Tun
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
keywords: (100.0100) Image processing; (100.2960) Image analysis; (110.4500) Optical coherence tomography; (170.4470) Ophthalmology