title: Vitamin D receptor gene polymorphisms and type 2 diabetes: a meta-analysis.
abstract: OBJECTIVE
  A number of studies have shown that polymorphisms in the vitamin D receptor (VDR) gene are implicated in susceptibility to type 2 diabetes (T2D). However, the results are inconsistent and inconclusive.
  
  
  METHODS
  A meta-analysis was performed to analyze the association among the four polymorphisms (FokI, BsmI, ApaI and TaqI) in the VDR gene and T2D susceptibility. A total of 14 articles were included in this meta-analysis.
  
  
  RESULTS
  FokI polymorphism was associated with an overall significantly increased risk of T2D (f vs. F: OR = 1.25, 95% CI = 1.10, 1.41; the extreme model ff vs. FF: OR = 1.48, 95% CI: 1.13, 1.94; the recessive model ff vs. Ff + FF: OR = 1.51, 95% CI = 1.25, 1.82). Subgroup analysis revealed a significant association between the Fok1 polymorphism and T2D in an Asian population.
  
  
  CONCLUSIONS
  There was no between-study heterogeneity in any of these analyses. No significant associations were observed among the BsmI, ApaI and TaqI variants andT2D risk. This meta-analysis suggests that the FokI polymorphism of the VDR gene could be a risk factor for T2D, especially in an Asian population.
authors.affiliation: Department of Gastroenterology, Shandong Provincial Hospital, Shandong University, Jinan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.forename: Ji-Yong
authors.initials: JY
authors.lastname: Liu
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Yang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017594:Publication Bias; D018167:Receptors, Calcitriol / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D018167:Receptors, Calcitriol