title: From macrohemodynamic to the microcirculation.
abstract: ICU patients need a prompt normalization of macrohemodynamic parameters. Unfortunately, this optimization sometimes does not protect patients from organ failure development. Prevention or treatment of organ failure needs another target to be pursued: the microcirculatory restoration. Microcirculation is the ensemble of vessels of maximum 100 μm in diameter. Nowadays the Sidestream Dark Field (SDF) imaging technique allows its bedside investigation and a recent round-table conference established the criteria for its evaluation. First, microcirculatory derangements have been studied in sepsis: they are mainly characterized by a reduction of vessel density, an alteration of flow, and a heterogeneous distribution of perfusion. Endothelial malfunction and glycocalyx rupture were proved to be the main reasons for the observed microthrombi, capillary leakage, leukocyte rolling, and rouleaux phenomenon, even if further studies are necessary for a better explanation. Therapeutic approaches targeting microcirculation are under investigation. Microcirculatory alterations have been recently demonstrated in other diseases such as hypovolemia and cardiac failure but this issue still needs to be explored. The aim of this paper is to gather the already known information, focus the reader's attention on the importance of microvascular physiopathology in critical illness, and prompt him to actively participate to achieve a more comprehensive understanding of the issue.
authors.affiliation: Sezione di Anestesia e Rianimazione, Dipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Via Tronto 10, 60020 Torrette (Ancona), Italy ; AOU Ospedali Riuniti, Via Conca 71, 60020 Ancona, Italy ; Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Abele
authors.initials: A
authors.lastname: Donati
authors.forename: Roberta
authors.initials: R
authors.lastname: Domizi
authors.forename: Elisa
authors.initials: E
authors.lastname: Damiani
authors.forename: Erica
authors.initials: E
authors.lastname: Adrario
authors.forename: Paolo
authors.initials: P
authors.lastname: Pelaia
authors.forename: Can
authors.initials: C
authors.lastname: Ince