title: Influence of peri-implant artifacts on bone morphometric analysis with micro-computed tomography.
abstract: OBJECTIVE
  To determine the optimal dilation pixel size distance from the mini-implant interface needed to compensate for the metal artifact on micro-computed tomography (micro-CT) for bone morphometric analysis.
  
  
  METHODS
  A total of 72 self-drilling mini-implants were placed into the buccal alveolar bone of six male beagle dogs. After 12 weeks of orthodontic loading, specimens were harvested and scanned with micro-CT (Skyscan 1076) at a resolution of 9 μm. Using the reload plug-in and dilation procedure of CTAn, the percentage of bone-implant contact (BIC) and bone volume density (BV/TV, bone volume/total volume), respectively, were measured from one to seven pixels from the metal implant surface. Each pixel size of dilation (PSD) were compared with that of a ground histologic section, and the optimal PSD for bone morphometric analysis using micro-CT was determined.
  
  
  RESULTS
  BIC values from micro-CT analysis decreased when the PSD increased (P < .05). BIC from micro-CT showed the highest correlation coefficient with BIC from histologic slides when the PSD was 5 to 7 (P < .05), whereas BV/TV from micro-CT showed a very high correlation with BV/TV from histologic slides in all ranges (P < .0001).
  
  
  CONCLUSIONS
  To measure BIC and BV/TV using micro-CT, at least 5 PSD from the metal implant surface is needed.
authors.affiliation: Department of Orthodontic, College of Dentistry of Craniofacial Deformity, Yonsei University, Seoul, Korea.
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Song
authors.forename: Jung Yul
authors.initials: JY
authors.lastname: Cha
authors.forename: Till Edward
authors.initials: TE
authors.lastname: Bechtold
authors.forename: Young Chel
authors.initials: YC
authors.lastname: Park
mesh_terms: D000539:Alveolar Process / Q000000981:diagnostic imaging* / Q000473:pathology; D000818:Animals; D016477:Artifacts; D015519:Bone Density; D059605:Dental Implant-Abutment Design; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D019232:Dental Restoration Failure; D004106:Dilatation / Q000379:methods; D004285:Dogs; D008297:Male; D016348:Osseointegration; D055114:X-Ray Microtomography / Q000379:methods
chemical_list: D015921:Dental Implants