title: Exosomal miRNAs as Biomarkers for Prostate Cancer.
abstract: miRNAs are small non-coding RNAs that finely regulate gene expression in cells. Alterations in miRNA expression have been associated with development of cancer, and miRNAs are now being investigated as biomarkers for cancer as well as other diseases. Recently, miRNAs have been found outside cells in body fluids. Extracellular miRNAs exist in different forms - associated with Ago2 proteins, loaded into extracellular vesicles (exosomes, microvesicles, or apoptotic bodies) or into high density lipoprotein particles. These extracellular miRNAs are probably products of distinct cellular processes, and might therefore play different roles. However, their functions in vivo are currently unknown. In spite of this, they are considered as promising, non-invasive diagnostic, and prognostic tools. Prostate cancer is the most common cancer in men in the Western world, but the currently used biomarker (prostate specific antigen) has low specificity. Therefore, novel biomarkers are highly needed. In this review we will discuss possible biological functions of extracellular miRNAs, as well as the potential use of miRNAs from extracellular vesicles as biomarkers for prostate cancer.
authors.affiliation: Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital - The Norwegian Radium Hospital Oslo, Norway ; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo Oslo, Norway.
authors.forename: Nina Pettersen
authors.initials: NP
authors.lastname: Hessvik
authors.forename: Kirsten
authors.initials: K
authors.lastname: Sandvig
authors.forename: Alicia
authors.initials: A
authors.lastname: Llorente
keywords: biofluids; biomarkers; exosomes; extracellular miRNA; microvesicles; prostate cancer