title: Macrophages: Good guys in colorectal cancer.
abstract: Macrophages play a complex role in tumor progression since they can exert both tumor-preventing (M1 macrophages) and tumor-promoting (M2 macrophages) activities. In colorectal carcinoma (CRC), at odds to many other cancers, macrophage infiltration has been correlated with an improved patient survival. In a recent study, we have evaluated the distribution of M1 and M2 macrophage subtypes in CRC and their impact on patient prognosis.
authors.affiliation: Department of Medical Biosciences, Pathology; Umeå University; Umeå, Sweden.
authors.forename: Sofia
authors.initials: S
authors.lastname: Edin
authors.forename: Maria L
authors.initials: ML
authors.lastname: Wikberg
authors.forename: Per-Arne
authors.initials: PA
authors.lastname: Oldenborg
authors.forename: Richard
authors.initials: R
authors.lastname: Palmqvist
keywords: CpG island methylator phenotype; colorectal cancer; macrophage subtypes; microsatellite instability; prognosis