title: Pollution level and human health risk assessment of some pesticides and polychlorinated biphenyls in Nantong of Southeast China.
abstract: Food consumption is one of the key exposure routes of humans to contaminants. This article evaluated the residue levels of 51 pesticides and 16 polychlorinated biphenyls (PCBs) in selected fish and food items which were commonly consumed in the Nantong area of Jiangsu Province, Southeast China. The 51 pesticides and 16 PCBs were analyzed by highly sensitive gas chromatography-tandem mass spectrometry (GC-MS/MS). The results showed that organochlorine pesticides such as dichlorodiphenyltrichloroethanes (DDTs), hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB) and mirex and other pesticides including chlorpyrifos, pyrethroid pesticides, metolachlor, pyridaben and trifluralin were frequently detected in the samples, which was consistent with the accumulation level and characteristics of these toxic chemicals in human adipose tissue of people living in Nantong. Meanwhile, correlation of the residue level of toxic chemicals with their physical chemical properties and historic use pattern in Nantong area was observed. Combined with dietary survey results at the same sampling locations, human health risk assessment of ingestion through the dietary route was performed. The results suggested that the non-cancer risks of the chemicals investigated can be considered negligible in the Nantong area, however, the cancer risks from lifetime dietary exposure to DDTs and HCB have exceeded the acceptable levels.
authors.affiliation: Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing 210042, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Yi
authors.forename: Lili
authors.initials: L
authors.lastname: Shi
authors.forename: Deyang
authors.initials: D
authors.lastname: Kong
authors.forename: Daoji
authors.initials: D
authors.lastname: Cai
authors.forename: Donghua
authors.initials: D
authors.lastname: Wang
authors.forename: Zhengjun
authors.initials: Z
authors.lastname: Shan
mesh_terms: D000818:Animals; D049872:Bivalvia; D002681:China; D004034:Diet Surveys; D005399:Fishes; D005506:Food Contamination; D006801:Humans; D010575:Pesticides / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000737:chemistry*; D018570:Risk Assessment; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000633:toxicity
chemical_list: D010575:Pesticides; D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls