title: Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits.
abstract: Deposition of aggregated Aβ peptide in the brain is one of the major hallmarks of Alzheimer's disease. Using a combination of two structurally different, but related, hypersensitive fluorescent amyloid markers, LCOs, reporting on separate ultrastructural elements, we show that conformational rearrangement occurs within Aβ plaques of transgenic mouse models as the animals age. This important mechanistic insight should aid the design and evaluation of experiments currently using plaque load as readout.
authors.affiliation: IFM-Department of Chemistry, Linköping University , Linköping, Sweden.
authors.forename: Sofie
authors.initials: S
authors.lastname: Nyström
authors.forename: Katarzyna M
authors.initials: KM
authors.lastname: Psonka-Antonczyk
authors.forename: Pål Gunnar
authors.initials: PG
authors.lastname: Ellingsen
authors.forename: Leif B G
authors.initials: LB
authors.lastname: Johansson
authors.forename: Nina
authors.initials: N
authors.lastname: Reitan
authors.forename: Susann
authors.initials: S
authors.lastname: Handrick
authors.forename: Stefan
authors.initials: S
authors.lastname: Prokop
authors.forename: Frank L
authors.initials: FL
authors.lastname: Heppner
authors.forename: Bettina M
authors.initials: BM
authors.lastname: Wegenast-Braun
authors.forename: Mathias
authors.initials: M
authors.lastname: Jucker
authors.forename: Mikael
authors.initials: M
authors.lastname: Lindgren
authors.forename: Bjørn Torger
authors.initials: BT
authors.lastname: Stokke
authors.forename: Per
authors.initials: P
authors.lastname: Hammarström
authors.forename: K Peter R
authors.initials: KP
authors.lastname: Nilsson
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000473:pathology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D061848:Optical Imaging; D058225:Plaque, Amyloid / Q000473:pathology*; D011487:Protein Conformation
chemical_list: D016229:Amyloid beta-Peptides