title: Comparison of two intravaginal progesterone releasing devices (PRID-Delta vs CIDR) in dairy cows: blood progesterone profile and field fertility.
abstract: Objectives were to compare circulating progesterone (P4) profile and pregnancies per AI (P/AI) of two commercial intravaginal P4 devices (PRID-Delta(®) vs CIDR(®)). In Experiment 1, ovariectomized dairy cows (PRID-Delta, n=6 vs CIDR, n=6) were sampled throughout 7 days to measure circulating P4. In Experiment 2 (PRID-Delta, n=399 vs CIDR, n=375), cows were assigned to treatments, as follows: D0, an intravaginal P4 device containing 1.38g of P4 (CIDR) or 1.55g of P4 (PRID-Delta); D6: 25mg PGF2α (Dinoprost) and P4 devices were removed 24h later. Insemination was performed at 56h after P4 removal. Cows visually detected in estrus between days 18 and 24 after 1st synchronized AI were re-inseminated. PRID-Delta produced greater circulating P4 compared to CIDR, particularly within 4 days after insertion (P<0.01). The logistic regression analysis indicated a tendency for improved P/AI at 1st AI in PRID-Delta cows compared to CIDR (36% vs 31%, P=0.10). More cows were detected in estrus in the following cycle nearly 21d after 1st AI when treated with PRID-Delta (28% vs 16%), but P/AI in the returning-natural estrus breedings did not differ (PRID-Delta=56% vs CIDR=55%; P=0.91). As a result, final cumulative P/AI was greater in cows receiving PRID-Delta (46% vs 37%, P=0.02). These results indicate that PRID-Delta seem to maintain greater circulating P4 levels as compared to CIDR in non-lactating dairy cows. This might explain potential benefits in fertility of dairy cows found in Experiment 2. Underlying physiological consequence of greater circulating P4 during synchronization programs in lactating cows in terms of oocyte quality and other reproductive structures warrants further investigation.
authors.affiliation: University Farm Animal Practice, Dorpsstraat 221a, Harmelen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: van Werven
authors.forename: F
authors.initials: F
authors.lastname: Waldeck
authors.forename: A H
authors.initials: AH
authors.lastname: Souza
authors.forename: S
authors.initials: S
authors.lastname: Floch
authors.forename: M
authors.initials: M
authors.lastname: Englebienne
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D002417:Cattle / Q000097:blood / Q000502:physiology; D003612:Dairying; D015237:Dinoprost / Q000008:administration & dosage / Q000493:pharmacokinetics; D004973:Estrus Synchronization / Q000379:methods; D005260:Female; D005298:Fertility / Q000187:drug effects* / Q000502:physiology; D007315:Insemination, Artificial / Q000706:statistics & numerical data / Q000662:veterinary; D007436:Intrauterine Devices, Medicated; D007774:Lactation / Q000097:blood / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D011374:Progesterone; D015237:Dinoprost