title: [Non-alcoholic fatty liver disease in obese children and adolescents].
abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in children and adolescents in industrialized countries. Recent studies have demonstrated a prevalence rate of NAFLD in overweight and obese children and adolescents in Germany of up to 30%. The spectrum of NAFLD ranges from pure fatty infiltration (simple steatosis) to inflammation (steatohepatitis, synonymous NASH) to fibrosis and cirrhosis. Age, gender, ethnicity, insulin resistance, and sex steroids are implicated in the pathogenesis of NAFLD in childhood and adolescence. Moreover, NAFLD in the pediatric age group is associated with marked cardiovascular comorbidities. This review focuses on current data regarding epidemiology, pathophysiology, comorbidities, and treatment of NAFLD in children and adolescents.
authors.affiliation: Sektion Pädiatrische Endokrinologie und Diabetologie, Universitätsklinik für Kinder und Jugendmedizin, Eythstr. 24, 89075, Ulm, Deutschland. Christian.Denzer@uniklinik-ulm.de
authors.forename: C
authors.initials: C
authors.lastname: Denzer
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004035:Diet Therapy / Q000706:statistics & numerical data*; D005081:Exercise Therapy / Q000706:statistics & numerical data*; D005234:Fatty Liver / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D063766:Pediatric Obesity / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D015995:Prevalence; D012307:Risk Factors; D016896:Treatment Outcome