title: Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo.
abstract: β-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified β-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these β-glucan rich compounds had marked effects in vivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.
authors.affiliation: Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.
authors.forename: Mohlopheni J
authors.initials: MJ
authors.lastname: Marakalala
authors.forename: David L
authors.initials: DL
authors.lastname: Williams
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Hoving
authors.forename: Rolf
authors.initials: R
authors.lastname: Engstad
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
authors.forename: Gordon D
authors.initials: GD
authors.lastname: Brown
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005936:Glucans / Q000276:immunology*; D037181:Lectins, C-Type / Q000276:immunology*; D008024:Ligands; D051379:Mice; D009102:Multiple Organ Failure; D013203:Staphylococcal Infections / Q000276:immunology / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000276:immunology; D015054:Zymosan / Q000276:immunology / Q000633:toxicity; D000099181:Dectin-1
chemical_list: D005936:Glucans; D037181:Lectins, C-Type; D008024:Ligands; D015054:Zymosan; D000099181:Dectin-1