title: A scalable and expedient route to 1-aza[6]helicene derivatives and its subsequent application to a chiral-relay asymmetric strategy.
abstract: A rapid route to diversely functionalized 1-aza[6]helicenes has been achieved via the development of a copper-mediated cross-coupling reaction, followed by PtCl4-catalyzed cycloisomerization. Not only does this method allow access to these functionally important molecules on gram scale, but this strategy is also suitable for relaying the axial chirality of a key intermediate to the helicity of the product.
authors.affiliation: Department of Chemistry, Imperial College London, London SW7 2AZ, United Kingdom.
authors.forename: Marko
authors.initials: M
authors.lastname: Weimar
authors.forename: Rosenildo
authors.initials: R
authors.lastname: Correa da Costa
authors.forename: Fu-Howe
authors.initials: FH
authors.lastname: Lee
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Fuchter