title: Altered microRNA expression in the ischemic-reperfusion spinal cord with atorvastatin therapy.
abstract: We explored the neuroprotection by atorvastatin in the ischemia/reperfusion model of rat and its microRNA-related mechanisms. At first, we uncovered a previously unknown alteration in temporal expression of a large set of microRNAs following spinal cord ischemia-reperfusion injury (IRI). The target genes for the differentially expressed microRNAs include genes encoding components that are involved in the inflammation, apoptosis, and neural damage that are known to play important roles in IRI. Atorvastatin pretreatment restored part of the up or down regulations. These findings suggest that altered expression of microRNAs may contribute to the mechanism of neuroprotection of statins in spinal cord IRI.
authors.affiliation: Department of Spine Surgery, the Second Xiangya Hospital of Central South University, PR China.
authors.forename: Jia-Rui
authors.initials: JR
authors.lastname: Hu
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Lv
authors.forename: Bang-Liang
authors.initials: BL
authors.lastname: Yin
mesh_terms: D000818:Animals; D000069059:Atorvastatin; D004195:Disease Models, Animal; D015870:Gene Expression / Q000187:drug effects*; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D035683:MicroRNAs / Q000378:metabolism*; D018696:Neuroprotective Agents; D011758:Pyrroles / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D060888:Real-Time Polymerase Chain Reaction; D015427:Reperfusion Injury / Q000235:genetics* / Q000473:pathology; D013116:Spinal Cord / Q000378:metabolism; D020760:Spinal Cord Ischemia / Q000235:genetics* / Q000473:pathology
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D035683:MicroRNAs; D018696:Neuroprotective Agents; D011758:Pyrroles; D000069059:Atorvastatin