title: Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors.
abstract: Binding of Leu-enkephalin and [Rh(III)(η(5)-Cp*)(η(6)-Tyr(1))]Leu-enkephalin to the recently published crystal structures of the μ- and δ-opioid receptor is studied. Docking of free Leu-enkephalin reveals two preferred conformations, one of which suggests an alternative binding site for the tyrosine residue. Furthermore, the three-dimensional solution structure of [Rh(III)(η(5)-Cp*)(η(6)-Tyr(1))]Leu-enkephalin was solved by using 2D NMR spectroscopic techniques.
authors.affiliation: Biomolecular NMR, Faculty of Chemistry and Biochemistry, Ruhr-University Bochum, Bochum, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Wieberneit
authors.forename: Annika
authors.initials: A
authors.lastname: Korste
authors.forename: H Bauke
authors.initials: HB
authors.lastname: Albada
authors.forename: Nils
authors.initials: N
authors.lastname: Metzler-Nolte
authors.forename: Raphael
authors.initials: R
authors.lastname: Stoll
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D004743:Enkephalin, Leucine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011957:Receptors, Opioid / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D011957:Receptors, Opioid; D004743:Enkephalin, Leucine; D012238:Rhodium