title: Mitochondria and cancer: past, present, and future.
abstract: The area of mitochondrial genomics has undergone unprecedented growth over the past several years. With the advent of the age of omics, investigations have reached beyond the nucleus to encompass the close biological communication and finely coordinated interactions between mitochondria and their nuclear cell mate. Application of this holistic approach, to all metabolic interactions within the cell, is providing a more complete understanding of the molecular transformation of the cell from normal to malignant behavior, before histopathological indications are evident. In this review the surging momentum in mitochondrial science, as it relates to cancer, is described in three progressive perspectives: (1) Past: the historical contributions to current directions of research; (2) Present: Contemporary findings, results and approaches to mitochondria and cancer, including the role of next generation sequencing and proteomics; (3) FUTURE: Based on the present body of knowledge, the potential assets and benefits of mitochondrial research are projected into the near future.
authors.affiliation: Juravinski Cancer Centre, 699 Concession Street, Hamilton, ON, Canada L8V 5C2.
authors.forename: M L
authors.initials: ML
authors.lastname: Verschoor
authors.forename: R
authors.initials: R
authors.lastname: Ungard
authors.forename: A
authors.initials: A
authors.lastname: Harbottle
authors.forename: J P
authors.initials: JP
authors.lastname: Jakupciak
authors.forename: R L
authors.initials: RL
authors.lastname: Parr
authors.forename: G
authors.initials: G
authors.lastname: Singh
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D004272:DNA, Mitochondrial / Q000378:metabolism; D054629:Genome, Mitochondrial / Q000235:genetics; D023281:Genomics; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D009154:Mutation; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D010084:Oxidation-Reduction; D011110:Polymorphism, Genetic; D040901:Proteomics / Q000379:methods; D017382:Reactive Oxygen Species / Q000378:metabolism; D017422:Sequence Analysis, DNA
chemical_list: D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species