title: Impending corneal perforation after collagen cross-linking for herpetic keratitis.
abstract: Collagen crosslinking (CXL) has been proposed as a treatment for infectious keratitis. Given the insurgence of antibiotic-resistant microorganisms and frequent toxicity of topical medications, CXL may be a potential treatment for corneal infections. However, corneal infection is itself a possible complication of this treatment. We describe a case of severe corneal thinning and melting in a woman who had a CXL procedure as a treatment for herpetic keratitis.
authors.affiliation: G.B. Bietti Foundation-IRCCS, Rome, Italy. ferrari.giulio@hsr.it
authors.forename: Giulio
authors.initials: G
authors.lastname: Ferrari
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Iuliano
authors.forename: Maurizia
authors.initials: M
authors.lastname: Viganò
authors.forename: Paolo
authors.initials: P
authors.lastname: Rama
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D003094:Collagen / Q000378:metabolism*; D003131:Combined Modality Therapy; D003315:Cornea / Q000473:pathology; D057112:Corneal Perforation / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D003319:Corneal Stroma / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016849:Keratitis, Herpetic / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D015948:Keratoplasty, Penetrating; D008875:Middle Aged; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011183:Postoperative Complications; D012256:Riboflavin / Q000627:therapeutic use; D014466:Ultraviolet Rays
chemical_list: D000998:Antiviral Agents; D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin; D000212:Acyclovir