title: Antitumoral potential of Tunisian snake venoms secreted phospholipases A2.
abstract: Phospholipases type A2 (PLA2s) are the most abundant proteins found in Viperidae snake venom. They are quite fascinating from both a biological and structural point of view. Despite similarity in their structures and common catalytic properties, they exhibit a wide spectrum of pharmacological activities. Besides being hydrolases, secreted phospholipases A2 (sPLA2) are an important group of toxins, whose action at the molecular level is still a matter of debate. These proteins can display toxic effects by different mechanisms. In addition to neurotoxicity, myotoxicity, hemolytic activity, antibacterial, anticoagulant, and antiplatelet effects, some venom PLA2s show antitumor and antiangiogenic activities by mechanisms independent of their enzymatic activity. This paper aims to discuss original finding against anti-tumor and anti-angiogenic activities of sPLA2 isolated from Tunisian vipers: Cerastes cerastes and Macrovipera lebetina, representing new tools to target specific integrins, mainly, α5β1 and αv integrins.
authors.affiliation: Laboratoire des Venins et Biomolecules Therapeutiques, Institut Pasteur de Tunis, 13, Place Pasteur, 1002 Tunis, Tunisia. zouari_raoudha@yahoo.fr
authors.forename: Raoudha
authors.initials: R
authors.lastname: Zouari-Kessentini
authors.forename: Najet
authors.initials: N
authors.lastname: Srairi-Abid
authors.forename: Amine
authors.initials: A
authors.lastname: Bazaa
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Ayeb
authors.forename: Jose
authors.initials: J
authors.lastname: Luis
authors.forename: Naziha
authors.initials: N
authors.lastname: Marrakchi
mesh_terms: D000595:Amino Acid Sequence; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D039081:Integrin alpha5beta1 / Q000378:metabolism; D039564:Integrin alphaV / Q000378:metabolism; D007527:Isoenzymes / Q000494:pharmacology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D054467:Phospholipases A2 / Q000494:pharmacology*; D017386:Sequence Homology, Amino Acid; D012910:Snake Venoms / Q000494:pharmacology*; D014416:Tunisia; D017819:Viperidae
chemical_list: D020533:Angiogenesis Inhibitors; D000925:Anticoagulants; D000970:Antineoplastic Agents; D039081:Integrin alpha5beta1; D039564:Integrin alphaV; D007527:Isoenzymes; D012910:Snake Venoms; D054467:Phospholipases A2