title: Direct electrical single-molecule detection of DNA through electron transfer induced by hybridization.
abstract: Single-stranded DNA was utilized as a probe tip for single-molecule DNA detection. Hybridization of the DNA tip and target DNA induces electron tunneling through the resulting DNA duplex. It is demonstrated that the DNA tip allows not only genetic detection but also discovery of single-nucleotide polymorphisms at the single-molecule level.
authors.affiliation: Nanoscience and Nanotechnology Research Center, Osaka Prefecture University, Sakai, Osaka 599-8570, Japan. t-nishino@21c.osakafu-u.ac.jp
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nishino
authors.forename: Phuc Tan
authors.initials: PT
authors.lastname: Bui
mesh_terms: D020137:Base Pair Mismatch; D004247:DNA / Q000032:analysis* / Q000378:metabolism; D004277:DNA, Single-Stranded / Q000737:chemistry / Q000378:metabolism; D055664:Electrochemical Techniques; D004566:Electrodes; D004579:Electron Transport; D006046:Gold / Q000737:chemistry; D017403:In Situ Hybridization
chemical_list: D004277:DNA, Single-Stranded; D006046:Gold; D004247:DNA