title: [Reactivity of intrapulmonary arterial rings to thromboxane A2 and endothelin-1 is reduced in patients with chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To investigate the reactivity of intrapulmonary arterial rings to vasoactive substances as thromboxane A2 and endothelin-1 in patients with chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  Intrapulmonary arterial rings isolated from patients with normal lung function and COPD were mounted in a Multi Myograph system to determine the reactivity of the intrapulmonary arterial rings to 60 mmol/L KCl, thromboxane A2 analogue U46619 and endothelin-1 before and after preconditioning with the COX synthase inhibitor indomethacin.
  
  
  RESULTS
  The reactivity of intrapulmonary arterial rings to U46619 and endothelin-1 was significantly decreased in patients with COPD. The reactivity to U46619 was dramatically decreased in patients with normal lung function after application of indomethacin.
  
  
  CONCLUSIONS
  The reactivity of intrapulmonary arterial rings is significantly decreased in patients with COPD.
authors.affiliation: Southern Medical University, Guangzhou 510515, China. coralchan33@126.com
authors.forename: Yijing
authors.initials: Y
authors.lastname: Chen
authors.forename: Chunyu
authors.initials: C
authors.lastname: Deng
authors.forename: Sujuan
authors.initials: S
authors.lastname: Kuang
authors.forename: Jue
authors.initials: J
authors.lastname: Ma
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhao
authors.forename: Guangyan
authors.initials: G
authors.lastname: Zhang
authors.forename: Jianxiu
authors.initials: J
authors.lastname: Cui
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000494:pharmacology; D000368:Aged; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism*; D013928:Thromboxane A2 / Q000378:metabolism*
chemical_list: D019332:Endothelin-1; D013928:Thromboxane A2; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D007213:Indomethacin