title: Preparation and protein immobilization of magnetic dialdehyde starch nanoparticles.
abstract: Superparamagnetic Fe3O4 nanoparticles were obtained using a hydrolysis product of starch, i.e., α-d-glucose, as the reducing agent and without any additional stabilizer and dispersant by a facile and green method at mild temperature. Magnetic dialdehyde starch nanoparticles (MDASN) were successfully synthesized with dialdehyde starch (DAS) as wrapper and epichlorohydrin as cross-linker by coembedding method. Bovine serum albumin (BSA) as a model drug was immobilized on the suface of MDASN. The particle size distribution of MDASN was 50-150 nm, and the average size was about 100 nm. The content of aldehyde group in DAS was 59.5%, and the package rate of DAS in MDASN was 33.2%. The loading amount and encapsulation efficiency of MDASN loading BSA were 5.0% and 54.4%, respectively. The saturation magnetization of MDASN at 300 K was 29.5 emu/g without coercivity and remanence. The as-prepared MDASN have not only lots of aldehyde functional groups but also stronger magnetic response, which might have potential applications such as drug carriers and targeted drug release.
authors.affiliation: School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039, PR China.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Lu
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Shen
authors.forename: Anjian
authors.initials: A
authors.lastname: Xie
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002417:Cattle; D003432:Cross-Linking Reagents / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004811:Epichlorohydrin / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D055772:Green Chemistry Technology; D055767:Immobilized Proteins / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D019163:Reducing Agents / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D004337:Drug Carriers; D055767:Immobilized Proteins; D058185:Magnetite Nanoparticles; D019163:Reducing Agents; D004811:Epichlorohydrin; D012710:Serum Albumin, Bovine; D013213:Starch; C012880:dialdehyde starch; D005947:Glucose; D052203:Ferrosoferric Oxide