title: Applicability of second-generation colon capsule endoscope to ulcerative colitis: a clinical feasibility study.
abstract: OBJECTIVE
  Colon capsule endoscopy has already been used for colon visualization and detection of polyps but its applicability to inflammatory bowel disease is still unconfirmed. The aim of this study was to assess the feasibility of evaluating the severity of mucosal inflammation in patients with ulcerative colitis (UC) using a second-generation colon capsule endoscope (CCE-2).
  
  
  METHODS
  Forty patients with histological confirmed diagnosis of UC were enrolled. Low-volume (2 L) polyethylene glycol solution with prokinetics (mosapride citrate and metoclopramide) regimen was used for the bowel preparation. In Phase 1, consisting of 10 patients, to confirm appropriate CCE-2 bowel preparation for UC. In Phase 2, consisting of 30 patients, CCE-2 was performed with a fixed bowel preparation regimen. CCE-2 findings were recorded for 8 h starting from capsule ingestion and conventional colonoscopy was subsequently performed on the same day. CCE-2 procedure completion rate and the colon cleansing level with a 4-point grading scale (poor, fair, good, and excellent) were evaluated in Phase 2. Correlations between Matts endoscopic scores as judged by CCE-2 and conventional colonoscopy were calculated.
  
  
  RESULTS
  CCE-2 procedure was completed within 8 h in 69% of the patients. The proportion of patients with good or excellent cleansing level was below 50%. However, Matts endoscopic scores determined by CCE-2 showed a strong correlation with scores obtained by conventional colonoscopy (average ρ = 0.797).
  
  
  CONCLUSIONS
  Although modifications in bowel preparation are needed, CCE-2 might be feasible for assessing the severity of mucosal inflammation in patients with UC.
authors.affiliation: Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan. nhosoe@z5.keio.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Hosoe
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Makoto
authors.initials: M
authors.lastname: Naganuma
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Ida
authors.forename: Yuka
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Kayoko
authors.initials: K
authors.lastname: Kimura
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Yoneno
authors.forename: Shingo
authors.initials: S
authors.lastname: Usui
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kashiwagi
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Hisamatsu
authors.forename: Nagamu
authors.initials: N
authors.lastname: Inoue
authors.forename: Takanori
authors.initials: T
authors.lastname: Kanai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Imaeda
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ogata
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
mesh_terms: D000328:Adult; D000368:Aged; D053704:Capsule Endoscopy; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000473:pathology*; D003113:Colonoscopy / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D055815:Young Adult