title: The many uses of autophagosomes.
abstract: Autophagy has emerged as a significant innate immune response to pathogens. Typically, autophagosomes deliver their contents to lysosomes for degradation. Some pathogens such as Salmonella enterica serovar Typhimurium succumb to autophagy and are transported to lysosomes for degradation. Yet, many professional pathogens, including Legionella pneumophila and Burkholderia cenocepacia, subvert this pathway exploiting autophagy to their advantage.
authors.affiliation: Department of Microbial Infection and Immunity, Ohio State University, Columbus, OH, USA.
authors.forename: Amal O
authors.initials: AO
authors.lastname: Amer
mesh_terms: D000818:Animals; D001343:Autophagy; D001419:Bacteria / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D010588:Phagosomes / Q000378:metabolism*
keywords: Anaplasma; Burkholderia; Francisella; Legionella; autophagosomes; bacteria; lysosome fusion