title: Bone and metabolic markers in women with recurrent calcium stones.
abstract: OBJECTIVE
  The target of our work was to study several biochemical parameters in phospho-calcic and bone metabolism in blood and urine and the bone mineral density of women with recurrent calcium nephrolithiasis.
  
  
  METHODS
  We conducted a cross-sectional study with a control group of 85 women divided into 3 groups: group 1 consisted of 25 women without a history of nephrolithiasis, group 2 consisted of 35 women with only one episode of calcium nephrolithiasis, and group 3 consisted of 25 women with a history of recurrent calcium nephrolithiasis. Blood and urine biochemical study was performed, including markers related to lithiasis, and a bone mineral density study was done by use of bone densitometry.
  
  
  RESULTS
  Patients in group 3 showed statistically significantly elevated calciuria (15.4 mg/dL), fasting calcium/creatinine ratio (0.14), and 24-hour calcium/creatinine ratio (0.21) compared with groups 1 and 2. Moreover, this group of women with recurrent calcium nephrolithiasis had significantly elevated values of beta-crosslaps, a bone resorption marker, compared with groups 1 and 2 (p=0.000) and showed more bone mineral density loss than did these groups.
  
  
  CONCLUSIONS
  Recurrent calcium nephrolithiasis in women has a significant association with bone mineral density loss and with values of calciuria, both fasting and 24-hour.
authors.affiliation: Department of Urology, San Cecilio University Hospital, Granada, Spain.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Arrabal-Polo
authors.forename: Miguel
authors.initials: M
authors.lastname: Arrabal-Martin
authors.forename: Salvador
authors.initials: S
authors.lastname: Arias-Santiago
keywords: Bone density; Calcium; Urolithiasis; Women