title: Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's disease.
abstract: BACKGROUND
  Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large-scale studies. Therefore, we assessed using a questionnaire-based diagnostic approach.
  
  
  METHODS
  The patient-administered RBD questionnaire and bed-partner-administered question 1 of the Mayo questionnaire were prospectively validated.
  
  
  RESULTS
  Seventy-five PD patients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty-eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%-100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram-confirmed RBD. Among those who achieved REM sleep (n=65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%-92.6%).
  
  
  CONCLUSIONS
  A combination of patient and bed-partner questionnaires is a useful tool to detect RBD.
authors.affiliation: Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. lamachahine@hotmail.com
authors.forename: Lama M
authors.initials: LM
authors.lastname: Chahine
authors.forename: Joseph
authors.initials: J
authors.lastname: Daley
authors.forename: Stacy
authors.initials: S
authors.lastname: Horn
authors.forename: Amy
authors.initials: A
authors.lastname: Colcher
authors.forename: Howard
authors.initials: H
authors.lastname: Hurtig
authors.forename: Charles
authors.initials: C
authors.lastname: Cantor
authors.forename: Nabila
authors.initials: N
authors.lastname: Dahodwala
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000150:complications*; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis* / Q000209:etiology*; D012372:ROC Curve; D057566:Self Report; D011795:Surveys and Questionnaires
keywords: Parkinson's disease; REM sleep behavior disorder