title: Manganese dioxide-methanesulfonic acid promoted direct dehydrogenative alkylation of sp3 C-H bonds adjacent to a heteroatom.
abstract: A manganese dioxide (MnO2)-methanesulfonic acid (CH3SO3H) oxidation system has been developed to efficiently promote direct coupling of benzylic ethers and carbamates with simple ketones via oxidative C-H bond activation. The alkylation proceeds smoothly under air atmosphere to afford the corresponding products in good to excellent yields (53-87%). The employment of the combination of MnO2 and CH3SO3H is attractive on the basis of economical and environmental issues.
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China.
authors.forename: Xigong
authors.initials: X
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Xie
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Qin
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Lou
mesh_terms: D000478:Alkylation; D006865:Hydrogenation; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D017895:Manganese Compounds / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*
chemical_list: D007659:Ketones; D017895:Manganese Compounds; D008698:Mesylates; D010087:Oxides; C045880:methanesulfonic acid; C016552:manganese dioxide