title: Regenerative therapy and tissue engineering for the treatment of end-stage cardiac failure: new developments and challenges.
abstract: Regeneration of myocardium through regenerative therapy and tissue engineering is appearing as a prospective treatment modality for patients with end-stage heart failure. Focusing on this area, this review highlights the new developments and challenges in the regeneration of myocardial tissue. The role of various cell sources, calcium ion and cytokine on the functional performance of regenerative therapy is discussed. The evolution of tissue engineering and the role of tissue matrix/scaffold, cell adhesion and vascularisation on tissue engineering of cardiac tissue implant are also discussed.
authors.affiliation: Polymer Science Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India.
authors.forename: G T
authors.initials: GT
authors.lastname: Finosh
authors.forename: Muthu
authors.initials: M
authors.lastname: Jayabalan
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D002448:Cell Adhesion; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D007477:Ions; D009203:Myocardial Infarction / Q000628:therapy; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000166:cytology; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D016207:Cytokines; D007477:Ions; D002118:Calcium
keywords: end-stage cardiac failure; new developments and challenges; regenerative therapy; tissue engineering