title: Dissociable functional networks of the human dentate nucleus.
abstract: The cerebellar dentate nucleus has been reported to project to motor and prefrontal cortical regions in nonhuman primates from 2 anatomically distinct areas. However, despite a wealth of human neuroimaging data implicating the cerebellum in motor and cognitive behaviors, evidence of dissociable motor and cognitive networks comprising the human dentate is lacking. To investigate the existence of these 2 networks in the human brain, we used resting-state functional connectivity magnetic resonance imaging. The resting-state fMRI signal was extracted from regions of interest in the dorsal and ventral dentate nucleus. We report a "motor" network involving the dorsal dentate, anterior regions of the cerebellum, and the precentral gyrus, and a "cognitive" network involving the ventral dentate, Crus I, and prefrontal cortex. The existence of these 2 distinct networks supports the notion that cerebellar involvement in cognitive tasks is above and beyond that associated with motor response components.
authors.affiliation: Department of Psychology.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Bernard
authors.affiliation: Functional MRI Laboratory.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Peltier
authors.affiliation: School of Kinesiology, and.
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Benson
authors.affiliation: Department of Psychology.
authors.forename: Jillian Lee
authors.initials: JL
authors.lastname: Wiggins
authors.affiliation: University of Maryland at College Park, College Park, MD 20740, USA.
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Jaeggi
authors.affiliation: Department of Psychology, University of Maryland at College Park, College Park, MD 20740, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Buschkuehl
authors.affiliation: Department of Psychology, Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA and.
authors.forename: John
authors.initials: J
authors.lastname: Jonides
authors.affiliation: Department of Psychology, Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA and.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Monk
authors.affiliation: Department of Psychology, School of Kinesiology, and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA and rseidler@umich.edu.
authors.forename: Rachael D
authors.initials: RD
authors.lastname: Seidler
mesh_terms: D001921:Brain / Q000502:physiology; D001931:Brain Mapping; D002529:Cerebellar Nuclei / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D015203:Reproducibility of Results; D012146:Rest; D055815:Young Adult
keywords: MRI; cerebellum; dentate nucleus; resting state connectivity