title: Anticancer activity of novel thiophenes containing a biological active diphenylsulfone, diazepin, piperidine, oxazepine, acryladehyde and sulfonamide moieties.
abstract: A variety of thiophene derivatives bearing diphenylsulfone 3,4, diazepines 5b, 6b, phenylamino 7, piperidine 8, benzylpiperidine 9, oxazepines 10b, 11b, acrylaldehydes 12-14 and benzeonesulfanamide 15 were synthesized. some newly synthesized compounds were evaluated for their in vitro cytotoxic activity against human tumor breast cancer cell lines. The tested compounds showed moderate to good cytotoxic activity and indeed, some of them were more potent than doxorubicin as a reference drug.
authors.affiliation: Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud Univ. Riyadh, Saudi Arabia.
authors.forename: M S
authors.initials: MS
authors.lastname: Alsaid
authors.forename: M G
authors.initials: MG
authors.lastname: El-Gazzar
authors.forename: M M
authors.initials: MM
authors.lastname: Ghorab
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D010077:Oxazepines / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010077:Oxazepines; D010880:Piperidines; D013449:Sulfonamides; D013876:Thiophenes