title: Resveratrol: new avenues for a natural compound in neuroprotection.
abstract: This review summarizes the effects of resveratrol in neurodegenerative diseases and speculates on the direction the field will take in the immediate future. In particular, we emphasize studies on the effects of resveratrol on new pathways related to neurodegenerative diseases such as inflammatory processes, mitochondrial biogenesis and its control through gamma coactivator 1-α (PGC1α), and the role of the tandem sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) in neurodegeneration and in neurohormesis. While not all reported results are free from controversy, the demographic shift toward an older population makes compounds with this broad spectrum of potential clinical applications particularly interesting.
authors.affiliation: Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina (IBUB), Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED). Universitat de Barcelona. Nucli Universitari de. pallas@ub.edu.
authors.forename: Mercè
authors.initials: M
authors.lastname: Pallàs
authors.forename: David
authors.initials: D
authors.lastname: Porquet
authors.forename: Alberto
authors.initials: A
authors.lastname: Vicente
authors.forename: Coral
authors.initials: C
authors.lastname: Sanfeliu
mesh_terms: D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001343:Autophagy; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000494:pharmacology*; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000502:physiology; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D001688:Biological Products; D018696:Neuroprotective Agents; D013267:Stilbenes; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077185:Resveratrol