title: One-lung ventilation does not result in cerebral desaturation during application of lung protective strategy if normocapnia is maintained.
abstract: BACKGROUND
  Previously a report has suggested that administration of lung protective strategy for one-lung ventilation(OLV) results in oxygen desaturation of the brain parenchyma. The aim of our work was to confirm that the maintenance of normocapnia during protective OLV strategy results in alteration of cerebral blood fl ow and cerebral oxygen saturation as compared to double-lung ventilation.
  
  
  METHODS
  Data were obtained from 24 patients undergoing thoracic surgery. Cerebral oxygen saturation (rSO2) was continuously monitored by INVOS 5100C Cerebral Oxymeter System along with measurement of cerebral blood fl ow velocity (MCAV) by transcranial Doppler sonography. Arterial blood samples were taken for blood gas analysis in the awake state, in the supine and lateral decubitus position during double-lung ventilation (DLV), and during OLV.
  
  
  RESULTS
  When ventilation was changed from DLV to OLV, no significant change was observed in rSO2. A significant decrease of rSO2 was found compared to the value observed during DLV in lateral decubitus at the time point 60 minutes after the start of OLV. No clinically significant changes in the MCAV was observed throughout the course of the thoracic surgical procedure.
  
  
  CONCLUSIONS
  OLV does not result in clinically relevant decreases in cerebral blood fl ow and cerebral oxygen saturation during application of lung protective ventilation if normocapnia is maintained.
authors.affiliation: University of Debrecen Departments of Anesthesiology and Intensive Care Debrecen Hungary Outcomes Research Consortium Cleveland USA University of Debrecen Department of Anesthesiology and IC, Medical and Health Science Center Nagyerdei krt 98 H-4032 Debrecen Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Végh
authors.forename: S
authors.initials: S
authors.lastname: Szatmári
authors.forename: M
authors.initials: M
authors.lastname: Juhász
authors.forename: I
authors.initials: I
authors.lastname: László
authors.forename: A
authors.initials: A
authors.lastname: Vaskó
authors.forename: I
authors.initials: I
authors.lastname: Takács
authors.forename: L
authors.initials: L
authors.lastname: Szegedi
authors.forename: B
authors.initials: B
authors.lastname: Fülesdi
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D061810:One-Lung Ventilation / Q000379:methods*; D010100:Oxygen / Q000097:blood; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen