title: Modeling and simulation for drug discovery and development: current practices and opportunities for advancement.
abstract: This editorial reviews capabilities and usage domains of modeling and simulation software in support of drug development and discovery. Existing models simulate a subset of biological phenomena and lack integration. Development of precise unified systems models for a wide range of biological processes would greatly facilitate drug development and discovery. To improve modeling and simulation, iterative development combining in vitro, in vivo, and in silico source data are recommended.
authors.affiliation: University of Texas at Dallas, School of Management, SM33, 800 West Campbell Road, Richardson, TX, 75080, USA mark.thouin@utdallas.edu.
authors.forename: Mark F
authors.initials: MF
authors.lastname: Thouin