title: Redox-activated manganese-based MR contrast agent.
abstract: Here we report a simple Mn coordination complex with utility as a redox-sensitive MR probe. The HBET ligand stabilizes both the Mn(2+) and Mn(3+) oxidation states. In the presence of glutathione (GSH), low relaxivity Mn(III)-HBET is converted to high relaxivity Mn(II)-HBET with a 3-fold increase in relaxivity, and concomitant increase in MR signal. Alternately, hydrogen peroxide can convert Mn(II)-HBET to Mn(III)-HBET with a reduction in MR signal.
authors.affiliation: A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Suite 2301, Charlestown, Massachusetts 02129, USA.
authors.forename: Galen S
authors.initials: GS
authors.lastname: Loving
authors.forename: Shreya
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Peter
authors.initials: P
authors.lastname: Caravan
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D008345:Manganese; D006861:Hydrogen Peroxide; D005978:Glutathione