title: Feast or famine: the host-pathogen battle over amino acids.
abstract: Intracellular bacterial pathogens often rely on their hosts for essential nutrients. Host cells, in turn, attempt to limit nutrient availability, using starvation as a mechanism of innate immunity. Here we discuss both host mechanisms of amino acid starvation and the diverse adaptations of pathogens to their nutrient-deprived environments. These processes provide both key insights into immune subversion and new targets for drug development.
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Yanjia J
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Rubin
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001419:Bacteria / Q000378:metabolism* / Q000472:pathogenicity*; D002468:Cell Physiological Phenomena; D003593:Cytoplasm / Q000378:metabolism* / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans
chemical_list: D000596:Amino Acids