title: Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumption.
abstract: OBJECTIVE
  Pantothenic acid (PaA) is a vitamin that is an integral part of coenzyme A (CoA). CoA is an essential coenzyme in fat metabolism. The aim of this study was to determine whether PaA deficiency causes the accumulation of tissue fats and, if so, can refeeding of PaA decrease such accumulated fat.
  
  
  METHODS
  Weaning rats were fed the PaA-free diet for 30 d. Rats were then divided into two groups. One group was continuously fed the PaA-free diet, and the other was fed the PaA-containing diet for an additional 13 d. At the end of the experiment, liver fat and perinephric fat were weighed, and plasma triglyceride levels measured. An additional similar experiment was conducted in which rats consumed 15% ethanol instead of water.
  
  
  RESULTS
  Fat that accumulated by consuming the PaA-free diet for 30 d was decreased by consuming the PaA-containing diet for an additional 13 d. Ethanol feeding elicited much greater accumulation of liver, perinephric, and plasma fats if rats were fed the PaA-free diet. In such cases, administration of PaA could decrease the accumulated fat.
  
  
  CONCLUSIONS
  PaA deficiency causes fat accumulation, and readministration of PaA decreases the tissue fat in rats fed the pantothenic acid-free diet. Ethanol accelerated the accumulation of fat in rats fed the PaA-free diet. PaA could be beneficial for decreasing accumulated tissue fat.
authors.affiliation: Department of Food Science and Nutrition, School of Human Cultures, University of Shiga Prefecture, Hikone, Japan. kshibata@shc.usp.ac.jp
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shibata
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fukuwatari
authors.forename: Saori
authors.initials: S
authors.lastname: Higashiyama
authors.forename: Chisa
authors.initials: C
authors.lastname: Sugita
authors.forename: Isao
authors.initials: I
authors.lastname: Azumano
authors.forename: Masaaki
authors.initials: M
authors.lastname: Onda
mesh_terms: D000818:Animals; D003065:Coenzyme A / Q000378:metabolism; D004032:Diet; D000431:Ethanol / Q000009:adverse effects*; D005234:Fatty Liver / Q000209:etiology / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010205:Pantothenic Acid / Q000172:deficiency / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000627:therapeutic use; D014804:Vitamin B Deficiency / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D014886:Weaning
chemical_list: D008055:Lipids; D014803:Vitamin B Complex; D010205:Pantothenic Acid; D000431:Ethanol; D003065:Coenzyme A