title: Protoporphyrin IX/Cobyrinate Derived Hybrids - Novel Activators of Soluble Guanylyl Cyclase.
abstract: A new cobyrinate/protoporphyrin IX molecular hybrids were prepared via CuAAC reaction. The synthesis involved selective preparation of cobyrinate and PpIX derived building blocks possessing respectively terminal alkyne and azide moieties followed by the CuOAc catalyzed cycloaddition reaction. Synthesized molecules activated soluble guanylyl cyclase showing strong linker length/activation dependence.
authors.affiliation: Institute of Organic Chemistry Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Chromiński
authors.forename: Keith Ó
authors.initials: KO
authors.lastname: Proinsias
authors.forename: Emil
authors.initials: E
authors.lastname: Martin
authors.forename: Dorota
authors.initials: D
authors.lastname: Gryko
keywords: Protoporphyrin IX; Vitamin B12; enzyme activation; ‘click’ chemistry