title: Short-term tolerability of morniflumate in patients with cutaneous hypersensitivity reactions to non-steroidal anti-inflammatory drugs.
abstract: Morniflumate is the morpholinoethyl ester of niflumic acid, a non-steroidal anti-inflammatory drug, derived from nicotinic acid. We studied 112 patients who had experienced cutaneous reactions after using non-steroidal anti-inflammatory drugs. Only two of all the patients who underwent an oral challenge with morniflumate had a positive result to the test. By demonstrating the low incidence of reactions to morniflumate through oral challenges, we suggest that patients with non-steroidal anti-inflammatory drug hypersensitivity may tolerate this drug which would therefore be a useful alternative.
authors.forename: F
authors.initials: F
authors.lastname: Mero
authors.forename: E
authors.initials: E
authors.lastname: Nettis
authors.forename: A M
authors.initials: AM
authors.lastname: Aloia
authors.forename: E
authors.initials: E
authors.lastname: Di Leo
authors.forename: A
authors.initials: A
authors.lastname: Ferrannini
authors.forename: A
authors.initials: A
authors.lastname: Vacca
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009544:Niflumic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009544:Niflumic Acid; C027859:morniflumate