title: Acyl glycosides lignans, coumarins, and terpenes from the stems of Erycibe obtusifolia.
abstract: Nine new acyl glycosides, obtusifosides A-I (1-9), and eight known compounds have been isolated from an EtOH extract of the stems of Erycibe obtusifolia. Their structures were elucidated on the basis of a spectroscopic data analysis (NMR, HRESIMS, and CD) and chemical evidence. The hepatoprotective effects of some of the compounds from d-galactosamine-induced cytotoxicity in HL-7702 hepatic cells were evaluated. Compounds 1, 10, 11, 13, 16, and 17 showed significant hepatoprotective activities compared with the positive control bicyclol at concentrations of 1×10(-5)M.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Zhao-Zhen
authors.initials: ZZ
authors.lastname: Liu
authors.forename: Zhi-Lai
authors.initials: ZL
authors.lastname: Zhan
authors.forename: Fu
authors.initials: F
authors.lastname: Liu
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Yang
authors.forename: Zi-Ming
authors.initials: ZM
authors.lastname: Feng
authors.forename: Jian-Shuang
authors.initials: JS
authors.lastname: Jiang
authors.forename: Pei-Cheng
authors.initials: PC
authors.lastname: Zhang
mesh_terms: D001713:Biphenyl Compounds / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002942:Circular Dichroism; D027722:Convolvulaceae / Q000737:chemistry*; D003374:Coumarins / Q000302:isolation & purification*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005688:Galactosamine / Q000009:adverse effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology*; D013729:Terpenes / Q000302:isolation & purification*
chemical_list: D001713:Biphenyl Compounds; D003374:Coumarins; D006027:Glycosides; D017705:Lignans; D010936:Plant Extracts; D020011:Protective Agents; D013729:Terpenes; D005688:Galactosamine; C477843:bicyclol