title: Hemolytic anemia and methemoglobinemia in a preterm baby as a complication of antenatal intraamnial injection of toluidine blue.
abstract: A late preterm infant was born 4.5 h after intraamniotic injection of 90 mg of Toluidine blue to confirm premature rupture of membranes. Due to the fetal exposition to the dye, the entire body of the patient was blue stained and the baby suffered from methemoglobinemia, Heinz' body positive hemolytic anemia and hyperbilirubinaemia requiring exchange transfusion. These complications underline that antenatal exposition of toluidine blue may result in considerable postnatal infant morbidity. Therefore intraamniotic application of toluidine blue should be discouraged.
authors.affiliation: Children's Hospital, University of cologne, Cologne, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Mehler
authors.forename: A
authors.initials: A
authors.lastname: Oberthuer
authors.forename: G
authors.initials: G
authors.lastname: Weisshaar
authors.forename: M
authors.initials: M
authors.lastname: Valter
authors.forename: A
authors.initials: A
authors.lastname: Vierzig
authors.forename: F
authors.initials: F
authors.lastname: Eifinger
mesh_terms: D000328:Adult; D000650:Amnion; D000745:Anemia, Hemolytic, Congenital / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D002585:Cesarean Section; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis*; D005500:Follow-Up Studies; D005858:Germany; D005865:Gestational Age; D006366:Heinz Bodies; D006801:Humans; D006932:Hyperbilirubinemia / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D007267:Injections; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D011247:Pregnancy; D014048:Tolonium Chloride / Q000009:adverse effects*
chemical_list: D014048:Tolonium Chloride