title: Actin cytoskeleton manipulation by effector proteins secreted by diarrheagenic Escherichia coli pathotypes.
abstract: The actin cytoskeleton is a dynamic structure necessary for cell and tissue organization, including the maintenance of epithelial barriers. Disruption of the epithelial barrier coincides with alterations of the actin cytoskeleton in several disease states. These disruptions primarily affect the paracellular space, which is normally regulated by tight junctions. Thereby, the actin cytoskeleton is a common and recurring target of bacterial virulence factors. In order to manipulate the actin cytoskeleton, bacteria secrete and inject toxins and effectors to hijack the host cell machinery, which interferes with host-cell pathways and with a number of actin binding proteins. An interesting model to study actin manipulation by bacterial effectors is Escherichia coli since due to its genome plasticity it has acquired diverse genetic mobile elements, which allow having different E. coli varieties in one bacterial species. These E. coli pathotypes, including intracellular and extracellular bacteria, interact with epithelial cells, and their interactions depend on a specific combination of virulence factors. In this paper we focus on E. coli effectors that mimic host cell proteins to manipulate the actin cytoskeleton. The study of bacterial effector-cytoskeleton interaction will contribute not only to the comprehension of the molecular causes of infectious diseases but also to increase our knowledge of cell biology.
authors.affiliation: Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Apartado Postal 14-740, 07000 México, DF, Mexico. fnavarro@cell.cinvestav.mx
authors.forename: Fernando
authors.initials: F
authors.lastname: Navarro-Garcia
authors.forename: Antonio
authors.initials: A
authors.lastname: Serapio-Palacios
authors.forename: Paul
authors.initials: P
authors.lastname: Ugalde-Silva
authors.forename: Gabriela
authors.initials: G
authors.lastname: Tapia-Pastrana
authors.forename: Lucia
authors.initials: L
authors.lastname: Chavez-Dueñas
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D054324:Enterohemorrhagic Escherichia coli / Q000378:metabolism / Q000472:pathogenicity; D054308:Enteropathogenic Escherichia coli / Q000378:metabolism / Q000472:pathogenicity; D004847:Epithelial Cells / Q000382:microbiology; D004848:Epithelium / Q000378:metabolism / Q000382:microbiology; D004926:Escherichia coli / Q000378:metabolism* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000378:metabolism; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D014774:Virulence; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; D008840:Microfilament Proteins; D037521:Virulence Factors