title: [Therapy of hepatocellular carcinoma before liver transplantation].
abstract: Liver transplantation is the optimal therapy for patients with non-resectable early stage hepatocellular carcinoma (HCC) which is limited to the liver. During the sometimes long waiting period patients usually receive neoadjuvant bridging therapy to avoid tumor progression. The armamentarium of bridging therapies includes local ablative and systemic therapies as well as liver resection. The oncological benefit of neoadjuvant therapy for patients who receive a liver transplantation is unclear; however, bridging therapy keeps patients eligible for transplantation in the formal framework of current allocation rules. Moreover, response to therapy may serve as a surrogate marker for favorable tumor biology and may therefore help to guide the selection process for patients undergoing liver transplantation for HCC.
authors.affiliation: Klinik für Allgemeine-, Viszeral-, Transplantations-, Gefäß- und Thoraxchirurgie, Klinikum der Universität München, Campus Großhadern, Marchioninistr. 15, 81377, München, Deutschland. Markus.Guba@med.uni-muenchen.de
authors.forename: M
authors.initials: M
authors.lastname: Guba
authors.forename: M
authors.initials: M
authors.lastname: Angele
authors.forename: M
authors.initials: M
authors.lastname: Rentsch
authors.forename: K W
authors.initials: KW
authors.lastname: Jauch
authors.forename: R
authors.initials: R
authors.lastname: Zachoval
authors.forename: F
authors.initials: F
authors.lastname: Kolligs
authors.forename: A
authors.initials: A
authors.lastname: Gerbes
authors.forename: C J
authors.initials: CJ
authors.lastname: Bruns
mesh_terms: D002102:Cadaver; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D018450:Disease Progression; D058625:End Stage Liver Disease / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D016031:Liver Transplantation; D020360:Neoadjuvant Therapy; D011379:Prognosis; D014019:Tissue Donors / Q000600:supply & distribution; D014850:Waiting Lists