title: Genome-wide linkage and regional association study of obesity-related phenotypes: the GenSalt study.
abstract: OBJECTIVE
  To identify chromosomal regions harboring quantitative trait loci for waist circumference (WC) and body mass index (BMI).
  
  
  METHODS
  A genome-wide linkage scan and regional association study WC and BMI among 633 Chinese families was conducted.
  
  
  RESULTS
  A significant linkage signal for WC was observed at 22q13.31-22q13.33 in the overall analysis (LOD = 3.13). Follow-up association study of 22q13.31-13.33 revealed an association between the TBC1D22A gene marker rs16996195 and WC (false discovery rate [FDR]-Q < 0.05). In gender-stratified analysis, suggestive linkage signals were attained for WC at 2p24.3-2q12.2 and 22q13.33 among females (LOD = 2.54 and 2.15, respectively). Among males, 6q12-6q13 was suggestively linked to BMI (LOD = 2.03). Single marker association analyses at these regions identified male-specific relationships of six single nucleotide polymorphisms (SNPs) at 2p24.3-2q12.2 (rs100955, rs13020676, rs13014034, rs12990515, rs17024325, and rs2192712) and five SNPs at 6q12-6q13 (rs7747318, rs7767301, rs12197115, rs12203049, and rs9454847) with the obesity-related phenotypes (all FDR-Q < 0.05). At chromosome 6q12-6q13, markers rs7755450 and rs11758293 predicted BMI in females (both FDR-Q < 0.05).
  
  
  CONCLUSIONS
  Genomic regions on chromosomes 2, 6, and 22 which may harbor important obesity-susceptibility loci were described. Follow-up study of these regions revealed several novel variants associated with obesity related traits. Future work to confirm these promising findings is warranted.
authors.affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill School of Global Public Health, Chapel Hill, North Carolina, USA.
authors.forename: Angela Y
authors.initials: AY
authors.lastname: Liu
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
authors.forename: James E
authors.initials: JE
authors.lastname: Hixson
authors.forename: Dabeeru C
authors.initials: DC
authors.lastname: Rao
authors.forename: Lawrence C
authors.initials: LC
authors.lastname: Shimmin
authors.forename: Cashell E
authors.initials: CE
authors.lastname: Jaquish
authors.forename: De-Pei
authors.initials: DP
authors.lastname: Liu
authors.forename: Jiang
authors.initials: J
authors.lastname: He
authors.forename: Tanika N
authors.initials: TN
authors.lastname: Kelly
mesh_terms: D044466:Asian People; D015992:Body Mass Index; D002681:China; D002889:Chromosomes, Human, Pair 2; D002892:Chromosomes, Human, Pair 22; D002896:Chromosomes, Human, Pair 6; D004039:Diet, Sodium-Restricted; D005260:Female; D020690:GTPase-Activating Proteins / Q000235:genetics* / Q000378:metabolism; D056726:Genetic Association Studies; D008040:Genetic Linkage; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D017419:Potassium, Dietary / Q000627:therapeutic use; D040641:Quantitative Trait Loci; D012727:Sex Characteristics; D055105:Waist Circumference
chemical_list: D020690:GTPase-Activating Proteins; D017419:Potassium, Dietary; C582818:TBC122B protein, human