title: Nordihydroguaiaretic acid attenuates the oxidative stress-induced decrease of CD33 expression in human monocytes.
abstract: Nordihydroguaiaretic acid (NDGA) is a natural lignan with recognized antioxidant and beneficial properties that is isolated from Larrea tridentata. In this study, we evaluated the effect of NDGA on the downregulation of oxidant stress-induced CD33 in human monocytes (MNs). Oxidative stress was induced by iodoacetate (IAA) or hydrogen peroxide (H(2)O(2)) and was evaluated using reactive oxygen species (ROS) production, and cell viability. NDGA attenuates toxicity, ROS production and the oxidative stress-induced decrease of CD33 expression secondary to IAA or H(2)O(2) in human MNs. It was also shown that NDGA (20  μ M) attenuates cell death in the THP-1 cell line that is caused by treatment with either IAA or H(2)O(2). These results suggest that NDGA has a protective effect on CD33 expression, which is associated with its antioxidant activity in human MNs.
authors.affiliation: Departamento de Microbiología en Investigación, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, Calzada de Tlalpan 4502, Sección XVI, 14080 México, DF, Mexico.
authors.forename: Silvia
authors.initials: S
authors.lastname: Guzmán-Beltrán
authors.forename: José
authors.initials: J
authors.lastname: Pedraza-Chaverri
authors.forename: Susana
authors.initials: S
authors.lastname: Gonzalez-Reyes
authors.forename: Fernando
authors.initials: F
authors.lastname: Hernández-Sánchez
authors.forename: Ulises E
authors.initials: UE
authors.lastname: Juarez-Figueroa
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Gonzalez
authors.forename: Karen
authors.initials: K
authors.lastname: Bobadilla
authors.forename: Martha
authors.initials: M
authors.lastname: Torres
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D015536:Down-Regulation; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity; D007461:Iodoacetates / Q000633:toxicity; D032442:Larrea / Q000737:chemistry; D009637:Masoprocol / Q000737:chemistry / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D063268:Sialic Acid Binding Ig-like Lectin 3 / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D007461:Iodoacetates; D017382:Reactive Oxygen Species; D063268:Sialic Acid Binding Ig-like Lectin 3; D009637:Masoprocol; D006861:Hydrogen Peroxide; D005978:Glutathione