title: A feasibility study of the effect of intra-articular corticosteroid injection on isokinetic muscle strength in children with juvenile idiopathic arthritis.
abstract: This study assessed the magnitude of changes in isokinetic muscle strength in children with juvenile idiopathic arthritis (JIA) before and after treatment with intra-articular corticosteroid injection and assessed the feasibility of a larger study of the same effect. Isokinetic dynamometry was used to measure peak knee extension and flexion torque in 12 children before and after treatment for unilateral knee arthritis. Extensor and flexor strength was reduced on the affected side before treatment (-0.56 Nm/kg, p = .004 and -0.24 Nm/kg, p = .02 respectively). Increases in extensor strength were observed at two weeks (p = .01) and twelve weeks postinjection (p = .03). Improvements at 6 weeks approached but did not reach statistical significance (p = .17). Improvements in flexor strength were not observed until 12 weeks postinjection (p = .03). Despite significant improvements in extensor strength, low peak knee extensor torque continued to be observed at 12 weeks (p = .01). Knee extensor and flexor strength is reduced in children with JIA with active arthritis and improves following intra-articular corticosteroid injection. Significant improvements in knee extensor and flexor strength were seen postinjection; however deficits in extensor strength were still evident at three months. Isokinetic dynamometry was safe and well tolerated in our sample of children with JIA with active arthritis.
authors.affiliation: Dept. of Rheumatology, Sydney Children's Hospitals Network, Sydney, NSW, Australia.
authors.forename: Damien
authors.initials: D
authors.lastname: McKay
authors.forename: Genevieve
authors.initials: G
authors.lastname: Ostring
authors.forename: Carolyn
authors.initials: C
authors.lastname: Broderick
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Chaitow
authors.forename: Davinder
authors.initials: D
authors.lastname: Singh-Grewal
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint; D008137:Longitudinal Studies; D008297:Male; D053580:Muscle Strength / Q000187:drug effects*; D053581:Muscle Strength Dynamometer / Q000009:adverse effects; D018482:Muscle, Skeletal / Q000503:physiopathology; D009929:Organ Size / Q000187:drug effects; D016059:Range of Motion, Articular; D013848:Thigh / Q000473:pathology* / Q000503:physiopathology; D013997:Time Factors; D019415:Torque
chemical_list: D000305:Adrenal Cortex Hormones