title: Depressed-Type Colonic Lesions and "De Novo" Cancer in Familial Adenomatous Polyposis: A Colonoscopist's Viewpoint.
abstract: Familial adenomatous polyposis (FAP) is the most common inherited polyposis syndrome. Almost all patients with FAP will develop colorectal cancer if their FAP is not identified and treated at an early stage. Although there are many reports about polypoid lesions and colorectal cancers in FAP patients, little information is available concerning depressed lesions in FAP patients. Several reports suggested that depressed-type lesions are characteristic of FAP and important in the light of their rapid growth and high malignancy. Here, we describe the occurrence of depressed-type lesions in FAP patients treated at our institution. Between April 2001 and March 2010, eight of 18 FAP patients had colorectal cancers. Depressed-type colorectal cancer was found in three patients. It should be kept in mind that depressed-type lesions occur even in FAP.
authors.affiliation: Digestive Disease Center Showa University Northern Yokohama Hospital, Chigasaki Chuo 35-1, Tsuzuki-ku, Yokohama, Kanagawa-ken 224-8503, Japan.
authors.forename: Shin-Ei
authors.initials: SE
authors.lastname: Kudo
authors.forename: Yuusaku
authors.initials: Y
authors.lastname: Sugihara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kida
authors.forename: Fumio
authors.initials: F
authors.lastname: Ishida
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Miyachi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Mori
authors.forename: Masashi
authors.initials: M
authors.lastname: Misawa
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Hisayuki
authors.forename: Kenta
authors.initials: K
authors.lastname: Kodama
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Wakamura
authors.forename: Takemasa
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Wada
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Hamatani