title: [The effect of fatty component of diet and coenzyme Q10 on rat sufficiency with vitamins-antioxidans in chronic experiments].
abstract: The full replacement of fatty component of a diet (10% of feed mass, sunflower-seed oil and lard 1:1) on enriched with alpha-tocopherol acetate fish oil or on linen oil under additional coenzyme Q10 intake (100 mg per 1 kg body weight) within 12 months led to a significant vitamin A blood serum decrease on 23-31%, 2-2,8 fold fall of vitamin E blood serum level and vitamin C rat liver diminution due to significant dehydroascorbic acid reduction on 28-45%. In both cases, the intensification of POL was not observed. The use of palm-oil as a fatty component led to a significant vitamin A blood serum decrease on 31%, but didn't effect on all other investigated parameters. The deterioration of antioxidant status indexes (MDA in blood serum and liver and diene conjugates in serum), observed after 3 months of the additional PUFA omega-3 introduction into the diet under coenzyme Q10 intake, after the 12-month use of modified diet leveled. Age increase of vitamin A blood serum concentration in rats fed diets with high PUFA omega-3 content was 2-fold higher and amounted to 68-78% compared to 31-33% in the control group of rats and rats treated with palm oil. Alpha-Tocopherol serum content was significantly increased in all groups with increasing of rats age. 8,9 fold elevation was observed in the group of animals treated with linseed oil, and 2,5-3,2 fold in all other groups. The conclusion about the necessity of supplementary intake of vitamin E or a complex of vitamins-antioxidants under enrichment of a diet with omega-3 polyunsaturated fatty acids has been done.
authors.forename: O A
authors.initials: OA
authors.lastname: Vrzhesinskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Beketova
authors.forename: O V
authors.initials: OV
authors.lastname: Kosheleva
authors.forename: Z V
authors.initials: ZV
authors.lastname: Karagodina
authors.forename: O G
authors.initials: OG
authors.lastname: Pereverzeva
authors.forename: V M
authors.initials: VM
authors.lastname: Zhminchenko
authors.forename: V M
authors.initials: VM
authors.lastname: Kodentsova
authors.forename: A V
authors.initials: AV
authors.lastname: Vasil'ev
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D015525:Fatty Acids, Omega-3 / Q000493:pharmacokinetics / Q000494:pharmacology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D000073878:Palm Oil; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D014815:Vitamins / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D010938:Plant Oils; D014815:Vitamins; D014451:Ubiquinone; D008315:Malondialdehyde; D000073878:Palm Oil; C024989:coenzyme Q10