title: One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial.
abstract: OBJECTIVE
  To evaluate the effect of initial low energy permissive underfeeding ("trophic feeding") versus full energy enteral feeding ("full feeding") on physical function and secondary outcomes in patients with acute lung injury.
  
  
  METHODS
  Prospective longitudinal follow-up evaluation of the NHLBI ARDS Clinical Trials Network's EDEN trial
  
  
  METHODS
  41hospitals in the United States.
  
  
  METHODS
  525 patients with acute lung injury.
  
  
  METHODS
  Randomised assignment to trophic or full feeding for up to six days; thereafter, all patients still receiving mechanical ventilation received full feeding.
  
  
  METHODS
  Blinded assessment of the age and sex adjusted physical function domain of the SF-36 instrument at 12 months after acute lung injury. Secondary outcome measures included survival; physical, psychological, and cognitive functioning; quality of life; and employment status at six and 12 months.
  
  
  RESULTS
  After acute lung injury, patients had substantial physical, psychological, and cognitive impairments, reduced quality of life, and impaired return to work. Initial trophic versus full feeding did not affect mean SF-36 physical function at 12 months (55 (SD 33) v 55 (31), P=0.54), survival to 12 months (65% v 63%, P=0.63), or nearly all of the secondary outcomes.
  
  
  CONCLUSIONS
  In survivors of acute lung injury, there was no difference in physical function, survival, or multiple secondary outcomes at 6 and 12 month follow-up after initial trophic or full enteral feeding.
  
  
  BACKGROUND
  NCT No 00719446.
authors.affiliation: Outcomes After Critical Illness and Surgery Group, Johns Hopkins University, Baltimore, MD 21205, USA. dale.needham@jhmi.edu
authors.forename: Dale M
authors.initials: DM
authors.lastname: Needham
authors.forename: Victor D
authors.initials: VD
authors.lastname: Dinglas
authors.forename: O Joseph
authors.initials: OJ
authors.lastname: Bienvenu
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Colantuoni
authors.forename: Amy W
authors.initials: AW
authors.lastname: Wozniak
authors.forename: Todd W
authors.initials: TW
authors.lastname: Rice
authors.forename: Ramona O
authors.initials: RO
authors.lastname: Hopkins
mesh_terms: D055371:Acute Lung Injury / Q000401:mortality / Q000628:therapy*; D000328:Adult; D000368:Aged; D016638:Critical Illness / Q000401:mortality / Q000628:therapy; D002149:Energy Intake; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009751:Nutritional Requirements; D010288:Parenteral Nutrition / Q000379:methods*; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods; D018570:Risk Assessment; D016037:Single-Blind Method; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States