title: [Mean platelet volume and the extent of coronary atherosclerosis in patients with stable coronary artery disease].
abstract: OBJECTIVE
  The aim of this study was to assess the relationship between mean platelet volume (MPV) and the presence and extent of coronary artery disease (CAD) in patients who underwent coronary angiography for stable chest pain.
  
  
  METHODS
  A total of 540 patients (350 male, 190 female; mean age: 59.6±11.4 years) were consecutively included in the study. The patients were divided into four groups according to the presence and extent of their CAD as follows: Group 1 - patients with no significant CAD, group 2 - one vessel disease, group 3 - two vessel diseases, and group 4 - three vessel disease. Also, the Gensini score of each coronary angiogram was calculated.
  
  
  RESULTS
  There were 159 patients in group 1, 169 in group 2, 110 in group 3, and 102 in group 4. As expected, we found significant differences among the groups regarding mean age and other coronary risk factors including gender, hypertension, diabetes mellitus, hyperlipidemia, smoking, and family history of ischemic heart disease. However, there were no significant differences among the groups regarding platelet counts and MPV values (8.5±0.1 fl, 8.5±1.2 fl, 8.6±0.9 fl and 8.6±0.9 fl, MPV values of groups 1-4, respectively). Although the Gensini score was found to be significantly correlated with age, plasma uric acid level, white blood cell count, hemoglobin level, fasting blood glucose, and high density lipoprotein level, no significant association was detected between MPV and Gensini score values.
  
  
  CONCLUSIONS
  This study is one of the largest studies assessing the relationship between MPV and the extent of coronary atherosclerosis in patients with stable CAD to date. However, we found no association between MPV and the presence and extent of coronary atherosclerosis.
authors.affiliation: Department of Radiology, Türkiye Yüksek İhtisas Education and Research Hospital, Ankara, Turkey. adnkrn@gmail.com.
authors.forename: Adnan
authors.initials: A
authors.lastname: Karan
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Güray
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Güray
authors.forename: Burcu
authors.initials: B
authors.lastname: Demirkan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Astan
authors.forename: Erkan
authors.initials: E
authors.lastname: Baysal
authors.forename: Ayşe
authors.initials: A
authors.lastname: Çolak
authors.forename: Fatih Mehmet
authors.initials: FM
authors.lastname: Uçar
authors.forename: Ahmet
authors.initials: A
authors.lastname: Işleyen
authors.forename: Selçuk
authors.initials: S
authors.lastname: Kanat
authors.forename: Şule
authors.initials: Ş
authors.lastname: Korkmaz
mesh_terms: D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood; D003920:Diabetes Mellitus; D006801:Humans; D006973:Hypertension; D063847:Mean Platelet Volume