title: Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 2: is recombinant factor VIIa beneficial in the management of acute spontaneous intracerebral haemorrhage?
abstract: A short-cut review was carried out to establish whether recombinant factor VIIa (rFVIIa) improves survival and functional outcome in acute spontaneous intracranial haemorrhage. Ninety-two papers were found using the reported searches, of which two presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. It is concluded that current evidence does not support the use of rFVIIa in acute spontaneous intracranial haemorrhage.
authors.affiliation: Luton and Dunstable Hospital.
authors.forename: Edward
authors.initials: E
authors.lastname: Dewhirst
mesh_terms: D000208:Acute Disease; D002543:Cerebral Hemorrhage / Q000188:drug therapy*; D003029:Coagulants / Q000627:therapeutic use*; D055416:Evidence-Based Emergency Medicine; D015942:Factor VIIa / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D003029:Coagulants; D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa