title: Novel application of a multiscale entropy index as a sensitive tool for detecting subtle vascular abnormalities in the aged and diabetic.
abstract: Although previous studies have shown the successful use of pressure-induced reactive hyperemia as a tool for the assessment of endothelial function, its sensitivity remains questionable. This study aims to investigate the feasibility and sensitivity of a novel multiscale entropy index (MEI) in detecting subtle vascular abnormalities in healthy and diabetic subjects. Basic anthropometric and hemodynamic parameters, serum lipid profiles, and glycosylated hemoglobin levels were recorded. Arterial pulse wave signals were acquired from the wrist with an air pressure sensing system (APSS), followed by MEI and dilatation index (DI) analyses. MEI succeeded in detecting significant differences among the four groups of subjects: healthy young individuals, healthy middle-aged or elderly individuals, well-controlled diabetic individuals, and poorly controlled diabetic individuals. A reduction in multiscale entropy reflected age- and diabetes-related vascular changes and may serve as a more sensitive indicator of subtle vascular abnormalities compared with DI in the setting of diabetes.
authors.affiliation: Department of Electrical Engineering, National Dong Hwa University, Hualien, No. 1, Section 2, Da-Hsueh Road, Shoufeng, Hualien 97401, Taiwan. dsphans@mail.ndhu.edu.tw
authors.forename: Hsien-Tsai
authors.initials: HT
authors.lastname: Wu
authors.forename: Men-Tzung
authors.initials: MT
authors.lastname: Lo
authors.forename: Guan-Hong
authors.initials: GH
authors.lastname: Chen
authors.forename: Cheuk-Kwan
authors.initials: CK
authors.lastname: Sun
authors.forename: Jian-Jung
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000465:Algorithms; D000886:Anthropometry; D001794:Blood Pressure; D001808:Blood Vessels / Q000473:pathology*; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000175:diagnosis*; D019277:Entropy; D005260:Female; D006442:Glycated Hemoglobin / Q000737:chemistry; D006439:Hemodynamics; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D006442:Glycated Hemoglobin; D008055:Lipids