title: Effects of krill oil intake on plasma cholesterol and glucose levels in rats fed a high-cholesterol diet.
abstract: BACKGROUND
  In this study, whole krill oil (WKO) and phospholipid-type krill oil (PKO) with different lipid composition were prepared. The effects of KO intake on plasma cholesterol and glucose levels in Wistar rats fed a high-cholesterol diet (HCD) were investigated.
  
  
  RESULTS
  WKO contained 37.63% triglycerides, 48.37% phospholipids, 13.54% free fatty acids and 0.66% cholesterol, whereas the corresponding values for PKO were 0.59, 69.80, 28.53 and 1.09% respectively. Meanwhile, PKO contained much more polyunsaturated fatty acids (PUFA, 37.76%) than WKO (28.36%). After 4 weeks of HCD consumption, plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose increased significantly, but that of high-density lipoprotein cholesterol (HDL-C) decreased significantly. The intake of PKO and WKO for 4 weeks caused a significant reduction in body weight gain and plasma levels of TC and LDL-C in HCD-fed rats. Compared with WKO, PKO was more effective in decreasing plasma TC and LDL-C levels.
  
  
  CONCLUSIONS
  PKO showed better overall cholesterol-lowering effects than WKO, which may be due to its higher n-3 PUFA levels.
authors.affiliation: School of Food Science and Technology, Dalian Polytechnic University, Engineering Research Center of Seafood of Ministry of Education, International Science & Technology Cooperation Base for Precious Seafood Deep Processing, Dalian, 116034, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Li
authors.forename: Da-Yong
authors.initials: DY
authors.lastname: Zhou
authors.forename: Bei-Wei
authors.initials: BW
authors.lastname: Zhu
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Chi
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Sun
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Dong
authors.forename: Lei
authors.initials: L
authors.lastname: Qin
authors.forename: Wei-Zhou
authors.initials: WZ
authors.lastname: Qiao
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Murata
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000009:adverse effects; D004032:Diet; D033201:Euphausiacea; D009821:Oils / Q000737:chemistry / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D002791:Cholesterol, Dietary; D009821:Oils; D002784:Cholesterol
keywords: cholesterol-lowering effect; glucose-lowering effect; high-cholesterol-fed rat; krill oil; n-3 polyunsaturated fatty acids; phospholipids