title: Alkaloids from Lycoris caldwellii and their particular cytotoxicities against the astrocytoma and glioma cell lines.
abstract: Phytochemical investigation of the ethanol extract of the bulbs of Lycoris caldwellii afforded four new alkaloids, (+)-N-methoxylcarbonyl-nandigerine (1), (+)-N-methoxycarbonyl-lindcarpine (2), (+)-10-O-methylhernovine N-oxide (3), and (+)-3-hydroxy-anhydrolycorine N-oxide (4). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the alkaloids were in vitro evaluated for their cytotoxic activities against eight tumor cell lines (BEN-MEN-1, CCF-STTG1, CHG-5, SHG-44, U251, BGC-823, HepG2, and SK-OV-3). Alkaloids 1 and 2 exhibited particular cytotoxic activities against astrocytoma and glioma cell lines with IC₅₀ of 9.2-11.3 μM and 10.4-12.2 μM respectively.
authors.affiliation: Department of Neurosurgery, Institue of Neurology, General Hospital of Shenyang Military Area Command, #83 Wenhua Road, Shenhe District, Shenyang 110018, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cao
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Pan
authors.forename: Song
authors.initials: S
authors.lastname: Han
authors.forename: Chun-Yong
authors.initials: CY
authors.lastname: Yu
authors.forename: Qing-Jie
authors.initials: QJ
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Yong
authors.initials: Y
authors.lastname: Liang
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D000818:Animals; D001254:Astrocytoma / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D005910:Glioma / Q000188:drug therapy / Q000473:pathology; D056945:Hep G2 Cells; D006801:Humans; D031426:Lycoris
chemical_list: D000470:Alkaloids; D003603:Cytotoxins; D004365:Drugs, Chinese Herbal