title: SLC17: a functionally diverse family of organic anion transporters.
abstract: Molecular studies have determined that the SLC17 transporters, a family of nine proteins initially implicated in phosphate transport, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated by this family of proteins is involved in diverse processes ranging from the vesicular storage of the neurotransmitters, to urate metabolism, to the degradation and metabolism of glycoproteins.
authors.affiliation: Neurogenetics Division Department of Neurology and Neurological Sciences, Stanford University School of Medicine, P211 MSLS, 1201 Welch Road, Stanford, CA 94305, USA. rjreimer@stanford.edu
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Reimer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D027361:Organic Anion Transporters / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D010802:Phylogeny; D011487:Protein Conformation; D050609:Sodium-Phosphate Cotransporter Proteins, Type I / Q000235:genetics; D027981:Symporters / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D022161:Transport Vesicles / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D018377:Neurotransmitter Agents; D027361:Organic Anion Transporters; C493546:SLC17A1 protein, human; D050609:Sodium-Phosphate Cotransporter Proteins, Type I; D027981:Symporters; D014527:Uric Acid; D019158:N-Acetylneuraminic Acid