title: Chaste: an open source C++ library for computational physiology and biology.
abstract: Chaste - Cancer, Heart And Soft Tissue Environment - is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac electrophysiology and cancer development. A large number of cardiac electrophysiology studies have been enabled and performed, including high-performance computational investigations of defibrillation on realistic human cardiac geometries. New models for the initiation and growth of tumours have been developed. In particular, cell-based simulations have provided novel insight into the role of stem cells in the colorectal crypt. Chaste is constantly evolving and is now being applied to a far wider range of problems. The code provides modules for handling common scientific computing components, such as meshes and solvers for ordinary and partial differential equations (ODEs/PDEs). Re-use of these components avoids the need for researchers to 're-invent the wheel' with each new project, accelerating the rate of progress in new applications. Chaste is developed using industrially-derived techniques, in particular test-driven development, to ensure code quality, re-use and reliability. In this article we provide examples that illustrate the types of problems Chaste can be used to solve, which can be run on a desktop computer. We highlight some scientific studies that have used or are using Chaste, and the insights they have provided. The source code, both for specific releases and the development version, is available to download under an open source Berkeley Software Distribution (BSD) licence at http://www.cs.ox.ac.uk/chaste, together with details of a mailing list and links to documentation and tutorials.
authors.affiliation: Computational Biology, Department of Computer Science, University of Oxford, Oxford, United Kingdom. gary.mirams@cs.ox.ac.uk
authors.forename: Gary R
authors.initials: GR
authors.lastname: Mirams
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Arthurs
authors.forename: Miguel O
authors.initials: MO
authors.lastname: Bernabeu
authors.forename: Rafel
authors.initials: R
authors.lastname: Bordas
authors.forename: Jonathan
authors.initials: J
authors.lastname: Cooper
authors.forename: Alberto
authors.initials: A
authors.lastname: Corrias
authors.forename: Yohan
authors.initials: Y
authors.lastname: Davit
authors.forename: Sara-Jane
authors.initials: SJ
authors.lastname: Dunn
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Fletcher
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Harvey
authors.forename: Megan E
authors.initials: ME
authors.lastname: Marsh
authors.forename: James M
authors.initials: JM
authors.lastname: Osborne
authors.forename: Pras
authors.initials: P
authors.lastname: Pathmanathan
authors.forename: Joe
authors.initials: J
authors.lastname: Pitt-Francis
authors.forename: James
authors.initials: J
authors.lastname: Southern
authors.forename: Nejib
authors.initials: N
authors.lastname: Zemzemi
authors.forename: David J
authors.initials: DJ
authors.lastname: Gavaghan
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D016208:Databases, Factual; D006801:Humans; D008955:Models, Cardiovascular; D009369:Neoplasms