title: Protein oxidation in a group of subjects with metabolic syndrome.
abstract: OBJECTIVE
  To examine the protein oxidation, marker of the oxidative stress, in metabolic syndrome (MS).
  
  
  METHODS
  We enrolled 106 subjects (45 women and 61 men) with MS of which 43 (14 women and 27 men) were with diabetes mellitus and 63 (31 women and 32 men) were without diabetes mellitus, and 54 subjects (19 women and 35 men) as control group. The protein oxidation, expressed as carbonyl groups, was measured by an enzyme-like immunosorbent assay (ELISA) kit (BioCell PC test kit, Enzo Life Sciences AG, Switzerland).
  
  
  RESULTS
  In the whole group of MS subjects, in comparison with control group, a significant increase in carbonyl groups was present. The same datum was also evident between control group and diabetic subjects with MS and between control group and nondiabetic subjects with MS. No difference was observed between the two subgroups (diabetic and nondiabetic subjects with MS) about NOx. Few information were obtained examining the linear regression among carbonyl groups, age, BMI, waist circumference, blood pressure values and metabolic pattern of MS subjects.
  
  
  CONCLUSIONS
  In MS subject we observed an increase of protein oxidation not influenced by diabetes mellitus. Several strategies may be employed to reduce this parameter.
authors.affiliation: Dipartimento di Medicina Interna e Specialistica, Università di Palermo, Italy.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Caimi
authors.forename: Eugenia
authors.initials: E
authors.lastname: Hopps
authors.forename: Davide
authors.initials: D
authors.lastname: Noto
authors.forename: Baldassare
authors.initials: B
authors.lastname: Canino
authors.forename: Maria
authors.initials: M
authors.lastname: Montana
authors.forename: Daniela
authors.initials: D
authors.lastname: Lucido
authors.forename: Rosalia
authors.initials: R
authors.lastname: Lo Presti
authors.forename: Maurizio R
authors.initials: MR
authors.lastname: Averna
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007249:Inflammation / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D050050:Protein Carbonylation; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D009569:Nitric Oxide