title: Concentrations of amoxicillin and clindamycin in teeth following a single dose of oral medication.
abstract: OBJECTIVE
  The main purpose of this study is the detection of amoxicillin and clindamycin concentrations in teeth.
  
  
  METHODS
  Eleven patients received 2 g of amoxicillin, and 11 patients received 600 mg of clindamycin in a single dose of oral medication at least 60 min prior to tooth extraction due to systemic diseases. The concentrations were determined in crowns and roots separately using liquid chromatography-tandem mass spectrometry (LC-MS-MS).
  
  
  RESULTS
  Amoxicillin (13 samples) and clindamycin (12 samples) were detected in the samples of the root and crown preparations of the extracted teeth. The mean concentration of amoxicillin was 0.502 μg/g in the roots and 0.171 μg/g in the crowns. The mean concentration of clindamycin was 0.270 μg/g in the roots and 0.064 μg/g in the crowns.
  
  
  CONCLUSIONS
  A single dose of oral amoxicillin and clindamycin leads to concentrations of both antibiotics in teeth which exceed the minimal inhibition concentration of some oral bacteria.
  
  
  CONCLUSIONS
  The proof of antibacterial activity in dental hard tissue after oral single-dose application is new. The antimicrobial effect of amoxicillin and clindamycin concentrations in roots of teeth may be of clinical relevance to bacterial reinfection from dentinal tubules.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Albert-Ludwigs-Universität Freiburg, Hugstetterstr. 55, 79106, Freiburg, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Schüssl
authors.forename: Klaus
authors.initials: K
authors.lastname: Pelz
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kempf
authors.forename: Jörg-Elard
authors.initials: JE
authors.lastname: Otten
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002853:Chromatography, Liquid; D002981:Clindamycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D057230:Limit of Detection; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D053719:Tandem Mass Spectrometry; D014018:Tissue Distribution; D014070:Tooth / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin; D000658:Amoxicillin