title: Coadjuvant treatment with surgery and pirfenidone in severe facial trauma due to dog bite.
abstract: BACKGROUND
  This case report assesses the effectiveness of surgery plus pirfenidone (PFD) as a concomitant therapy in the management of facial trauma after severe dog bite.
  
  
  METHODS
  A 16-month-old female patient who suffered a severe attack by a big-sized dog (Rottweiler) in the midface area was managed with surgery/PFD combination and followed up for 20 months to evaluate the efficacy to control, prevent, and improve injury sequels.
  
  
  RESULTS
  Surgery/PFD combination offered a good complementary therapy downregulating inflammatory activity, improving blood supply, and activating cytokine modulation and collagen synthesis/biosynthesis (scar control). No side effects were reported in this case report.
  
  
  CONCLUSIONS
  Surgery/PFD management for severe facial dog bites represents a safe and effective therapeutic option to protect and improve a patient's quality of life, minimizing long-time sequels.
authors.affiliation: Hospital Pediátrico Tacubaya, Mexico City, Mexico.
authors.forename: María Zulema
authors.initials: MZ
authors.lastname: Cantú-Cantú
authors.forename: Iván
authors.initials: I
authors.lastname: Lyra-González
authors.forename: Juan
authors.initials: J
authors.lastname: Armendáriz-Borunda
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001733:Bites and Stings / Q000188:drug therapy* / Q000601:surgery*; D004285:Dogs; D005151:Facial Injuries / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D011728:Pyridones / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011728:Pyridones; C093844:pirfenidone