title: Association between maternal exposure to housing renovation and offspring with congenital heart disease: a multi-hospital case-control study.
abstract: BACKGROUND
  Congenital heart disease (CHD) is one of the most prevalent birth defects. Housing renovations are a newly recognized source of indoor environmental pollution that is detrimental to health. A growing body of research suggests that maternal occupational exposure to renovation materials may be associated with an increased risk of giving birth to fetuses with CHD. However, the effect of indoor housing renovation exposure on CHD occurrence has not been reported.
  
  
  METHODS
  A multi-hospital case-control study was designed to investigate the association between maternal periconceptional housing renovation exposure and the risk of CHD for offspring. In total, 346 cases and 408 controls were enrolled in this study from four hospitals in China. Exposure information was based on a questionnaire given to women during pregnancy. The association between housing renovation exposure and CHD occurrence was assessed by estimating odds ratios (OR) with logistic regression models adjusted for potential confounders.
  
  
  RESULTS
  The risk for CHD in offspring was significantly associated with maternal exposure to housing renovations (AOR: 1.89, 95% CI: 1.29-2.77). There were similar risks for cardiac defects with or without extra-cardiac malformation (AOR of 2.65 and 1.76, respectively). Maternal housing renovation exposure may increase the fetus' risk of suffering from conotruncal defect or anomalous venous return. There were significant risks for cardiac defects if the pregnant woman moved into a new house within one month after decoration at either 3 months before pregnancy (AOR: 2.38, 95% CI: 1.03 to 5.48) or during first trimester (AOR: 4.00, 95% CI: 1.62 to 9.86).
  
  
  CONCLUSIONS
  Maternal exposure to housing renovations may have an increased risk of giving birth to fetuses with some selected types of CHD. This relationship was stronger for women who moved into a newly decorated house. However, considering the limited number of subjects and the problem of multiple exposures, more research is needed to clarify the effects seen here.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Li
authors.forename: Nana
authors.initials: N
authors.lastname: Li
authors.forename: Shengli
authors.initials: S
authors.lastname: Li
authors.forename: Kui
authors.initials: K
authors.lastname: Deng
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lin
authors.forename: Xinlin
authors.initials: X
authors.lastname: Chen
authors.forename: Fengzhi
authors.initials: F
authors.lastname: You
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Dezhi
authors.initials: D
authors.lastname: Mu
authors.forename: Yanping
authors.initials: Y
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D060389:Construction Industry; D005260:Female; D006330:Heart Defects, Congenital / Q000139:chemically induced / Q000453:epidemiology*; D006798:Housing; D006801:Humans; D016015:Logistic Models; D018811:Maternal Exposure; D016273:Occupational Exposure; D016017:Odds Ratio; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D012306:Risk; D055815:Young Adult