title: Inhalation delivery of protein therapeutics.
abstract: Inhaled therapeutics are used routinely to treat a variety of pulmonary diseases including asthma, COPD and cystic fibrosis. In addition, biological therapies represent the fastest growing segment of approved pharmaceuticals. However, despite the increased availability of biological therapies, nearly all inhaled therapeutics are small molecule drugs with only a single inhaled protein therapeutic approved. There remains a significant unmet need for therapeutics in pulmonary diseases, and biological therapies with potential to alter disease progression represent a significant opportunity to treat these challenging diseases. This review provides a background into efforts to develop inhaled biological therapies and highlights some of the associated challenges. In addition, we speculate on the ideal properties of a biologic therapy for inhaled delivery.
authors.affiliation: Centyrex, Janssen Research & Development, 1400 McKean Road, Spring House, PA 19477, USA.
authors.forename: Colleen
authors.initials: C
authors.lastname: Kane
authors.forename: Karyn
authors.initials: K
authors.lastname: O'Neil
authors.forename: Michelle
authors.initials: M
authors.lastname: Conk
authors.forename: Kristen
authors.initials: K
authors.lastname: Picha
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001688:Biological Products / Q000008:administration & dosage*; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy*; D011506:Proteins / Q000008:administration & dosage*
chemical_list: D001688:Biological Products; D011506:Proteins