title: Fascia implantation with fibroblast growth factor on vocal fold paralysis.
abstract: OBJECTIVE
  The purpose of this prospective study was to determine the effect of autologous transplantation of fascia into the vocal fold (ATFV) with controlled release of basic fibroblast growth factor (bFGF) on unilateral vocal fold paralysis (UVFP) in a rat model.
  
  
  METHODS
  Unilateral recurrent laryngeal nerve (RLN) section was performed on 15 rats. Ten rats received an autologous fascia implant and gelatin hydrogel with or without bFGF (1 μg) to their larynxes (fascia only, "fascia group"; bFGF + fascia, "fascia + bFGF group"), while the rest underwent RLN transection ("RLN section group"). Four months later, evaluation of the laryngeal glottal gap and histological analysis were performed.
  
  
  RESULTS
  The glottal gap was significantly reduced in the fascia + bFGF group, and fat volume increased significantly relative to the RLN section. The volume of the remaining fascia in the bFGF + fascia group was significantly greater than that of the fascia group.
  
  
  CONCLUSIONS
  ATFV with controlled release of bFGF may compensate for diminished laryngeal volume in UVFP by reducing resorption of the implanted fascia and increasing fat volume. Our findings suggest that this modality may represent an attractive option for treating UVFP.
authors.affiliation: Department of Otolaryngology, Yamato Municipal Hospital, Yamato City, Kanagawa, Japan. hiromi.nagai@yamatocity-hosp.jp
authors.forename: Hiromi
authors.initials: H
authors.lastname: Nagai
authors.forename: Koichiro
authors.initials: K
authors.lastname: Nishiyama
authors.forename: Yutomo
authors.initials: Y
authors.lastname: Seino
authors.forename: Yu
authors.initials: Y
authors.lastname: Kimura
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tabata
authors.forename: Makito
authors.initials: M
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005205:Fascia / Q000637:transplantation*; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D019651:Plastic Surgery Procedures / Q000379:methods; D020127:Recovery of Function; D018709:Statistics, Nonparametric; D013524:Surgical Flaps / Q000098:blood supply*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014826:Vocal Cord Paralysis / Q000473:pathology / Q000601:surgery*; D014827:Vocal Cords / Q000187:drug effects / Q000601:surgery
chemical_list: D016222:Fibroblast Growth Factor 2