title: Triterpene esters and biological activities from edible fruits of Manilkara subsericea (Mart.) Dubard, Sapotaceae.
abstract: Manilkara subsericea (Mart.) Dubard (Sapotaceae) is popularly known in Brazil as "guracica." Studies with Manilkara spp indicated the presence of triterpenes, saponins, and flavonoids. Several activities have been attributed to Manilkara spp such as antimicrobial, antiparasitic and antitumoral, which indicates the great biological potential of this genus. In all, 87.19% of the hexanic extract from fruits relative composition were evaluated, in which 72.81% were beta- and alpha-amyrin esters, suggesting that they may be chemical markers for M. subsericea. Hexadecanoic acid, hexadecanoic acid ethyl ester, (E)-9-octadecenoic acid ethyl ester, and octadecanoic acid ethyl ester were also identified. Ethanolic crude extracts from leaves, stems, and hexanic extract from fruits exhibited antimicrobial activity against Staphylococcus aureus ATCC25923. These extracts had high IC50 values against Vero cells, demonstrating weak cytotoxicity. This is the first time, to our knowledge, that beta- and alpha-amyrin caproates and caprylates are described for Manilkara subsericea.
authors.affiliation: Laboratório de Tecnologia de Produtos Naturais, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Doutor Mário Viana 523, Santa Rosa, 24241-000 Niterói, RJ, Brazil.
authors.forename: Caio P
authors.initials: CP
authors.lastname: Fernandes
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Corrêa
authors.forename: Jonathas F R
authors.initials: JF
authors.lastname: Lobo
authors.forename: Otávio P
authors.initials: OP
authors.lastname: Caramel
authors.forename: Fernanda B
authors.initials: FB
authors.lastname: de Almeida
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Castro
authors.forename: Kauê F C S
authors.initials: KF
authors.lastname: Souza
authors.forename: Patrícia
authors.initials: P
authors.lastname: Burth
authors.forename: Lidia M F
authors.initials: LM
authors.lastname: Amorim
authors.forename: Marcelo G
authors.initials: MG
authors.lastname: Santos
authors.forename: José Luiz P
authors.initials: JL
authors.lastname: Ferreira
authors.forename: Deborah Q
authors.initials: DQ
authors.lastname: Falcão
authors.forename: José C T
authors.initials: JC
authors.lastname: Carvalho
authors.forename: Leandro
authors.initials: L
authors.lastname: Rocha
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004952:Esters / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D020128:Inhibitory Concentration 50; D032129:Manilkara / Q000737:chemistry*; D019308:Palmitic Acid / Q000032:analysis; D010936:Plant Extracts / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000378:metabolism; D013229:Stearic Acids / Q000032:analysis; D014315:Triterpenes / Q000737:chemistry*; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; D004952:Esters; D010936:Plant Extracts; D013229:Stearic Acids; D014315:Triterpenes; D019308:Palmitic Acid; C031183:stearic acid