title: Gastroesophageal reflux disease and its association with bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplant recipients.
abstract: OBJECTIVE
  Bronchiolitis obliterans syndrome is a significant postallogeneic hematopoietic stem cell transplant problem. Recent data in lung transplant patients suggest an association with gastroesophageal reflux disease and bronchiolitis obliterans syndrome. We studied posthematopoietic stem cell transplant patients with bronchiolitis obliterans syndrome for gastroesophageal reflux disease and its response to a proton pump inhibitor.
  
  
  METHODS
  Seven postallogeneic hematopoietic stem cell transplant patients with bronchiolitis obliterans syndrome were studied. Gastroesophageal reflux disease was assessed by 24-hour pH monitoring with a Bravo catheter-free radio pH capsule. Patients with positive gastroesophageal reflux disease were started on omeprazole. Pretreatment and posttreatment pulmonary function tests were done at 3-month intervals.
  
  
  RESULTS
  Of 7 patients, 5 had positive results for gastroesophageal reflux disease (71%). Omeprazole had a disease-stabilizing effect on the patients' pulmonary function tests.
  
  
  CONCLUSIONS
  Our study shows a significant association between bronchiolitis obliterans syndrome and gastroesophageal reflux disease in postallogeneic hematopoietic stem cell transplant patients. Use of omeprazole may have a disease-stabilizing effect in short-term follow-up.
authors.affiliation: Department of Pulmonary Medicine and Gastroenterology, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia. mkhalid@kfshrc.edu.sa
authors.forename: Mohammed
authors.initials: M
authors.lastname: Khalid
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Aljurf
authors.forename: Sarfraz
authors.initials: S
authors.lastname: Saleemi
authors.forename: Mohammed Qaseem
authors.initials: MQ
authors.lastname: Khan
authors.forename: Basha
authors.initials: B
authors.lastname: Khan
authors.forename: Shad
authors.initials: S
authors.lastname: Ahmed
authors.forename: Khalid El Tayeb
authors.initials: Kel T
authors.lastname: Ibrahim
authors.forename: Abdullah
authors.initials: A
authors.lastname: Mobeireek
authors.forename: Fahad
authors.initials: F
authors.lastname: Al Mohareb
authors.forename: Naeem
authors.initials: N
authors.lastname: Chaudhri
mesh_terms: D000328:Adult; D001989:Bronchiolitis Obliterans / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D050782:Esophageal pH Monitoring; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012129:Respiratory Function Tests; D012307:Risk Factors; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D054328:Proton Pump Inhibitors; D009853:Omeprazole