title: [Studies of effects of aluminum oxide nanoparticles after intragastric administration].
abstract: Growing Wistar rats received intragastrically nanoparticles (NPs) of aluminum oxide (Al2O3) daily during 28 days at doses of 1 or 100 mg per kg body mass. There were studied body mass of animals, relative mass of internals, rate of protein macromolecules absorption in the gut, oxidative damage of DNA, pool of tissue thiols, activity of hepatic enzymes of xenobiotic detoxication system, biochemical and hematological blood indices, stability of lysosome membranes, condition of antioxidant defense system, apoptosis of hepatocytes. Conducted experiments didn't reveal any marked toxic action of Al2O3 NPs on rats after 28 days of administration both in high and low dose. Among effects probably related to NPs influence on animals there were lowering of relative liver and lung masses, decrease of hepatic thiol pool, activity of CYP1A1 isoform in liver and glutathione reductase in erythrocytes, increase of diene conjugates of fatty acids in blood plasma. Said shifts were small in magnitude, didn't come out of margins of physiological norm and didn't show any distinct relation to NPs dose. However considering great importance of this nanomaterial as probable environmental contaminant the studies of it's toxicity must be continued in conditions of low doses (less than 1 mg per kg body mass) for long period of time.
authors.forename: A A
authors.initials: AA
authors.lastname: Shumakova
authors.forename: O N
authors.initials: ON
authors.lastname: Tananova
authors.forename: E A
authors.initials: EA
authors.lastname: Arianova
authors.forename: G Iu
authors.initials: GIu
authors.lastname: Mal'tsev
authors.forename: É N
authors.initials: ÉN
authors.lastname: Trushina
authors.forename: O K
authors.initials: OK
authors.lastname: Mustafina
authors.forename: G V
authors.initials: GV
authors.lastname: Guseva
authors.forename: N V
authors.initials: NV
authors.lastname: Trusov
authors.forename: S Kh
authors.initials: SKh
authors.lastname: Soto
authors.forename: N É
authors.initials: NÉ
authors.lastname: Sharanova
authors.forename: A V
authors.initials: AV
authors.lastname: Selifanov
authors.forename: I V
authors.initials: IV
authors.lastname: Gmoshinskiĭ
authors.forename: S A
authors.initials: SA
authors.lastname: Khotimchenko
mesh_terms: D000537:Aluminum Oxide / Q000009:adverse effects* / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D004249:DNA Damage; D004912:Erythrocytes / Q000378:metabolism / Q000473:pathology; D022781:Hepatocytes / Q000201:enzymology / Q000473:pathology; D007408:Intestinal Absorption / Q000187:drug effects; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008247:Lysosomes / Q000378:metabolism / Q000473:pathology; D008297:Male; D053758:Nanoparticles / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000097:blood; D013997:Time Factors
chemical_list: D000975:Antioxidants; D013438:Sulfhydryl Compounds; D019363:Cytochrome P-450 CYP1A1; D000537:Aluminum Oxide