title: [Cognitive disorders in multiple sclerosis: correlations between neuropsychological, neurophysiological and neuroimaging characteristics].
abstract: Multiple sclerosis (MS) is an autoimmune disease of CNS characterized by myelin destruction and axonal damage. An aim of the study was to analyze the results of neuropsychological tests, cognitive evoked potentials P300 and to evaluate a role of brain atrophy in MS. Neurocognitive functions have been studied in 109 patients with MS. To study cognitive functions, we used the Mini-Mental State Examination (MMSE), the frontal assessment battery, the procedure developed by A.R. Luriya, cognitive evoked potentials P300. Magnetic resonance imaging data were analyzed in 71 patients. Correlations between cognitive functions, the activity of the disease and the expression of brain atrophy were found.
authors.forename: V M
authors.initials: VM
authors.lastname: Alifirova
authors.forename: N F
authors.initials: NF
authors.lastname: Musina
mesh_terms: D000293:Adolescent; D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D009424:Nervous System Physiological Phenomena; D059906:Neuroimaging / Q000379:methods*; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D055815:Young Adult