title: Experimental assessment of temperature influence on miriplatin and cisplatin iodized-oil suspension viscosity.
abstract: OBJECTIVE
  To evaluate differences in the viscosity of a platinum iodized-oil suspension on the kind of platinum agent and temperature.
  
  
  METHODS
  Viscosities of a 70 mg miriplatin and 3.5 ml iodized-oil suspension (MO suspension) and that of 100 mg cisplatin and 10 ml iodized-oil suspension (CO suspension) were evaluated at three temperatures: 25, 37, and 50 °C. Iodized-oil was used as the control. Each liquid was injected into a capillary tube and allowed to drip separately. The liquid transit time was measured, and the viscosity of each liquid was calculated at each temperature.
  
  
  RESULTS
  The viscosity of each liquid decreased as the temperature increased: 43.3 ± 0.5, 39.2 ± 0.7, and 34.7 ± 0.6 mPa s for MO suspension, 41.3 ± 0.2, 36.9 ± 0.3, and 32.7 ± 0.9 mPa s for CO suspension, and 40.5 ± 0.2, 36.8 ± 0.2, and 33.8 ± 0.7 mPa s for iodized-oil at 25, 37, and 50 °C, respectively. The MO suspension group viscosity was significantly higher than that of the CO suspension group (p < 0.05) and the control (p < 0.05). Significant differences were found in viscosities among groups divided by temperature (25 °C-group vs. 37 °C-group, p < 0.05; 37 °C-group vs. 50 °C-group, p < 0.05).
  
  
  CONCLUSIONS
  The viscosity of the platinum iodized-oil suspension can be adjusted by changing temperature.
authors.affiliation: Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. hasegawat@clin.medic.mie-u.ac.jp
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Takaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Masashi
authors.initials: M
authors.lastname: Fujimori
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Nakatsuka
authors.forename: Junji
authors.initials: J
authors.lastname: Uraki
authors.forename: Tomomi
authors.initials: T
authors.lastname: Yamada
authors.forename: Hajime
authors.initials: H
authors.lastname: Sakuma
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yamakado
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D016461:Chemoembolization, Therapeutic / Q000379:methods; D002945:Cisplatin / Q000737:chemistry / Q000493:pharmacokinetics*; D005217:Fat Emulsions, Intravenous / Q000493:pharmacokinetics; D006801:Humans; D007459:Iodized Oil / Q000493:pharmacokinetics; D008113:Liver Neoplasms / Q000628:therapy; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D013696:Temperature; D013997:Time Factors; D014783:Viscosity
chemical_list: D000970:Antineoplastic Agents; D005217:Fat Emulsions, Intravenous; D009944:Organoplatinum Compounds; C406530:miriplatin; D007459:Iodized Oil; D002945:Cisplatin