title: [Hereditary thrombophilia and pregnancy: thrombotic risk and pregnancy outcome].
abstract: Thromboembolic disease and obstetric complications related to ischemia of the placenta are currently the major causes of maternal mortality and morbidity. Thrombophilia been implicated in their aetiology and the magnitude of the risk depends on the type of thrombophilia. As the evidence is still unclear and controversial, questions about the clinical management of pregnant women with thrombophilia are a daily issue. We aim to review, bearing in mind the consensus and controversies, the impact of inherited thrombophilia in the risk of thrombosis related to pregnancy and of obstetric complications. Moreover, the diagnostic, preventive and therapeutic approach during pregnancy and puerperium, including the role of antithrombotic pharmacopoeia available, will be discussed.
authors.affiliation: Serviço de Medicina, Hospital Garcia de Orta. Almada. & Departamento de Saúde Publica, Faculdade de Ciências Médicas, Lisboa, Portugal.
authors.forename: Ana Glória
authors.initials: AG
authors.lastname: Fonseca
mesh_terms: D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011256:Pregnancy Outcome; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy