title: 18F-FDG PET/CT demonstration of diffuse lymphohistiocytic granulomatous vasculitis.
abstract: Surveillance FDG PET/CT was performed in a 75-year-old woman with history of melanoma and colon cancer. She had rash and erythematous papules on the forearms, elbows, knees, and thighs and then developed right-leg weakness, difficulty with fine motor movement, and ptosis. Chest CT identified a right-lung spiculated nodule. Skin and pulmonary nodule biopsies showed lymphohistiocytic infiltrate with granulomatous features, without lymphoid cells, metastatic carcinoma or melanoma cells, or microorganisms. Epstein-Barr immunostain result was negative, making lymphomatoid granuloma unlikely. The inflammatory process involved the peripheral vasculature on FDG PET, and given the related neuropathy, findings were compatible with granulomatous vasculitis.
authors.affiliation: Stanford University Medical Center, and Division of Nuclear Medicine, Department of Radiology, Stanford University Medical Center, Stanford, CA 94305, USA.
authors.forename: Meena
authors.initials: M
authors.lastname: Kumar
authors.forename: Andrei
authors.initials: A
authors.lastname: Iagaru
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006099:Granuloma / Q000150:complications*; D015614:Histiocytosis / Q000150:complications*; D006801:Humans; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D019788:Fluorodeoxyglucose F18