title: Akathisia in association with herpes simplex encephalitis relapse and opercular syndrome in children.
abstract: We report a 2-year-old boy with herpes simplex virus type 1 encephalitis (HSE) and opercular syndrome who presented with clinical relapse characterized by chorea-like involuntary movements that suggest akathisia. The patient initially presented with multiple focal seizures that cause epilepsia partialis continua, polymerase chain reaction (PCR) for herpes simplex virus type 1 was positive. He developed hypersalivation, speech and swallowing difficulties within 30days. Based on these findings the patient was diagnosed as having opercular syndrome due to HSE. He developed akathisia on 44th day of admission as a relapse and he was successfully treated with propranolol. Opercular syndrome might be seen HSE in children and it may cause neurological suquela. Akathisia might be seen after encephalitic process as a symptom of relapse, however diagnosis of akathisia is difficult in young children. It should be noted that because propranolol effective for these involuntary movements. It can be add additional choice of treatment in these patients.
authors.affiliation: Department of Pediatric Neurology, Osmangazi University Medicine Faculty, Eskisehir, Turkey. Electronic address: ozankocak79@gmail.com.
authors.forename: Ozan
authors.initials: O
authors.lastname: Kocak
authors.affiliation: Department of Pediatric Neurology, Osmangazi University Medicine Faculty, Eskisehir, Turkey. Electronic address: coskunyarar26@yahoo.com.
authors.forename: Coskun
authors.initials: C
authors.lastname: Yarar
authors.affiliation: Department of Pediatric Neurology, Osmangazi University Medicine Faculty, Eskisehir, Turkey. Electronic address: ayakut@ogu.edu.tr.
authors.forename: Ayten
authors.initials: A
authors.lastname: Yakut
authors.affiliation: Department of Pediatric Neurology, Osmangazi University Medicine Faculty, Eskisehir, Turkey. Electronic address: drarzuekici@gmail.com.
authors.forename: Arzu
authors.initials: A
authors.lastname: Ekici
authors.affiliation: Department of Pediatric Neurology, Osmangazi University Medicine Faculty, Eskisehir, Turkey. Electronic address: sevgifahri@yahoo.com.
authors.forename: Sevgi
authors.initials: S
authors.lastname: Yimenicioglu
authors.affiliation: Department of Radiology, Osmangazi University Medicine Faculty, Eskisehir, Turkey. Electronic address: sunasel06@yahoo.com.
authors.forename: Suzan
authors.initials: S
authors.lastname: Saylisoy
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D020803:Encephalitis, Herpes Simplex / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D017034:Epilepsy, Frontal Lobe / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D011595:Psychomotor Agitation / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D011433:Propranolol
keywords: Akathisia; Opercular syndrome; Propranolol; Relapsing herpes simplex encephalitis