title: Outcome of radical surgery for pulmonary metastatic osteosarcoma with secondary spontaneous pneumothorax: case series report.
abstract: Secondary spontaneous pneumothorax (SSP) caused by malignant tumors is rare, which often makes the choice of treatment difficult. In our hospital, we performed radical surgery for all pulmonary metastases arising from osteosarcoma (OS) in seven patients with SSP from February 1988 to February 2008 and retrospectively examined the clinicopathological features and postoperative outcomes. The common SSP etiology was tumor tissue rupture at the lung periphery. All patients died of OS recurrence within 18 months. A short disease-free interval (DFI) and a short interval to the second recurrence were the common clinical risk factors of poor prognosis. Curative surgery for pulmonary metastases in OS with SSP is unlikely, but in OS patients with peripheral metastatic lesions that are not accompanied by SSP and have a satisfactory DFI and few lesions, surgical resection should be strongly considered.
authors.affiliation: Department of Thoracic Surgical Oncology, Japanese Foundation for Cancer Research, Cancer Institute Hospital.
authors.forename: Takeo
authors.initials: T
authors.lastname: Nakada
authors.forename: Sakae
authors.initials: S
authors.lastname: Okumura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kuroda
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Uehara
authors.forename: Mingyon
authors.initials: M
authors.lastname: Mun
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Sakao
authors.forename: Ken
authors.initials: K
authors.lastname: Nakagawa
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D059146:Metastasectomy / Q000379:methods*; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000150:complications / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D011013:Pneumonectomy / Q000379:methods*; D011030:Pneumothorax / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult