title: A mucin-rich variant of salivary duct carcinoma with a prominent mucinous component, a tumor that mimics mucinous adenocarcinoma.
abstract: The mucin-rich variant of salivary duct carcinoma (mSDC) is a rare type of salivary duct carcinoma. mSDC usually has both conventional SDC and mucinous adenocarcinoma-like areas. This article describes a first case of mSDC in which 95% of the tumor consisted of a mucinous area without no solid conventional SDC, so that the tumor mimicked mucinous adenocarcinoma. A 55-year-old man was evaluated for a 14 mm mass in the left submandibular gland. The tumor showed that floating tumor nests in a prominent mucinous lake. Some floating tumor nests had focal cribriform pattern with comedo necrosis, and all tumor cells had immunoreactivity for androgen receptor, gross cystic disease fluid protein 15, and Her-2/neu. A diagnosis of mSDC was rendered. mSDC with prominent mucinous component sometimes resembles mucinous adenocarcinoma. Identifying specific histological and immunohistochemical features of floating tumor nests in the mucinous area are important for the diagnosis.
authors.affiliation: Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan. mterasaki@nms.ac.jp
authors.forename: Mika
authors.initials: M
authors.lastname: Terasaki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Terasaki
authors.forename: Kyoko
authors.initials: K
authors.lastname: Wakamatsu
authors.forename: Mikiko
authors.initials: M
authors.lastname: Takahashi
authors.forename: Shinobu
authors.initials: S
authors.lastname: Kunugi
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Urushiyama
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sakanushi
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Okubo
authors.forename: Yuh
authors.initials: Y
authors.lastname: Fukuda
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018987:Salivary Ducts / Q000473:pathology*; D013365:Submandibular Gland Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor