title: New therapeutic approaches to acute myeloid leukemia.
abstract: BACKGROUND
  The heterogeneity of acute myeloid leukemia (AML) has been established by many new insights into the pathogenesis and treatment of patients with AML. Understanding the basic cellular and molecular pathogenesis of leukemic cells is vital to the development of new treatment approaches.
  
  
  OBJECTIVE
  To review progress until now with agents that are showing promise in the treatment of AML, we summarize the published preclinical and clinical trials that have been completed.
  
  
  RESULTS
  Based on recent progress of investigations, more specifically targeted agents have been developed for the treatment of AML such as tyrosine kinase inhibitors, monoclonal antibodies, epigenetic agents, antiangiogenic agents, and farnesyl transferase inhibitors.
  
  
  CONCLUSIONS
  In the future, in addition to performing therapeutic trials of these agents, it will be important to identify other highly specific therapeutic agents based on our evolving understanding of the biology of AML.
authors.affiliation: TEPCO Hospital, Department of Internal Medicine, Shinjuku-ku, Tokyo 160-0016, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Uchida
authors.forename: Koiti
authors.initials: K
authors.lastname: Inokuchi
authors.forename: Reiko
authors.initials: R
authors.lastname: Watanabe
authors.forename: Michihide
authors.initials: M
authors.lastname: Tokuhira
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kizaki