title: Treatment of peritoneal carcinomatosis from breast cancer by maximal cytoreduction and HIPEC: a preliminary report on 5 cases.
abstract: Although peritoneal carcinomatosis from breast cancer is a rare event it frequently causes morbidity and mortality. Current literature provides scarce information on its management. We report outcomes in 5 patients (mean age 59.4 years) with peritoneal carcinomatosis from breast cancer treated with maximal cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) by the closed technique, at 40 °C for 1 h with cisplatin 75 mg/m(2). The primary breast cancer was a ductal carcinoma in 3 patients and a lobular carcinoma in 2. Mean peritoneal cancer index was 20.2. In 4 of the 5 patients surgery achieved macroscopic complete cytoreduction. One patient died of disease at 56 months, 4 are alive and disease-free at 13, 45, 74 and 128 months. These encouraging outcomes suggest that cytoreduction and HIPEC is a promising approach to offer to highly selected patients with peritoneal carcinomatosis from breast cancer and that this approach merit investigation in a larger series.
authors.affiliation: Dipartimento di Chirurgia "P. Valdoni", Università di Roma "Sapienza", Azienda Policlinico Umberto I°, Viale del Policlinico 161, 00155 Rome, Italy. Electronic address: maurizio.cardi@uniroma1.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Cardi
authors.forename: Paolo
authors.initials: P
authors.lastname: Sammartino
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Framarino
authors.forename: Daniele
authors.initials: D
authors.lastname: Biacchi
authors.forename: Enrico
authors.initials: E
authors.lastname: Cortesi
authors.forename: Simone
authors.initials: S
authors.lastname: Sibio
authors.forename: Fabio
authors.initials: F
authors.lastname: Accarpio
authors.forename: Claudio
authors.initials: C
authors.lastname: Luciani
authors.forename: Antonella
authors.initials: A
authors.lastname: Palazzo
authors.forename: Angelo
authors.initials: A
authors.lastname: di Giorgio
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000556:secondary / Q000601:surgery / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000556:secondary / Q000601:surgery / Q000628:therapy*; D010534:Peritoneal Neoplasms / Q000556:secondary / Q000601:surgery / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: Breast cancer; Cytoreduction; HIPEC; Peritoneal metastases