title: HIV mother-to-child transmission: a complex genetic puzzle tackled by Brazil and Argentina research teams.
abstract: Human immunodeficiency virus (HIV) mother-to-child transmission is a complex event, depending upon environmental factors and is affected by host genetic factors from mother and child, as well as viral genetic elements. The integration of multiple parameters (CD4 cell count, virus load, HIV subtype, and host genetic markers) could account for the susceptibility to HIV infection, a multifactorial trait. The goal of this manuscript is to analyze the immunogenetic factors associated to HIV mother-to-child transmission, trying to unravel the genetic puzzle of HIV mother-to-child transmission and considering the experience in this topic of two research groups from Brazil and Argentina.
authors.affiliation: Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, s/n°, CEP 50.670-420, Cidade Universitária, Recife, Pernambuco, Brazil; Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Av. Prof. Moraes Rego, s/n°, CEP 50.670-420, Cidade Universitária, Recife, Pernambuco, Brazil.
authors.forename: R Celerino
authors.initials: RC
authors.lastname: da Silva
authors.forename: E
authors.initials: E
authors.lastname: Bedin
authors.forename: A
authors.initials: A
authors.lastname: Mangano
authors.forename: P
authors.initials: P
authors.lastname: Aulicino
authors.forename: A
authors.initials: A
authors.lastname: Pontillo
authors.forename: L
authors.initials: L
authors.lastname: Brandão
authors.forename: R
authors.initials: R
authors.lastname: Guimarães
authors.forename: L C
authors.initials: LC
authors.lastname: Arraes
authors.forename: L
authors.initials: L
authors.lastname: Sen
authors.forename: S
authors.initials: S
authors.lastname: Crovella
mesh_terms: D001118:Argentina; D001938:Brazil; D004198:Disease Susceptibility; D005260:Female; D015658:HIV Infections / Q000235:genetics / Q000276:immunology / Q000635:transmission / Q000821:virology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious
keywords: HIV; Host genome; Immunogenetics markers; Mother-to-child transmission; Protection; Susceptibility