title: [The use of reamberin for the correction of endogenous intoxication syndrome associated with salmonellosis].
abstract: The aim of the work was to study characteristics of endogenous intoxication (EI) associated with salmonellosis under conditions of basal therapy and its supplementation by detoxicant reamberin. The study included 66 patients with the gastroenteric variant of moderately severe S. enteriditis infection. The infection was accompanied by well-apparent manifestations of EI (increased leukocyte index, elevated level of medium weight molecules, and reduced detoxification potency of albumin) Persistent EI promotes development of secondary immunodeficiency; the recovery from the disease does not exclude long-term carriage of the pathogen and the development of chronic gastrointestinal diseases. It requires new approaches to the treatment of salmonellosis, such as the use of detoxicants like reamberin that decrease the severity of EI. It is concluded that introduction of reamberin in the combined treatment of salmonellosis can be recommended as a promising option for the management of infectious diseases.
authors.forename: V F
authors.initials: VF
authors.lastname: Pavelkina
authors.forename: R Z
authors.initials: RZ
authors.lastname: Al'miasheva
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Uskova
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged; D012480:Salmonella Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D012477:Salmonella enteritidis / Q000302:isolation & purification*; D013386:Succinates / Q000008:administration & dosage*; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C549374:Reamberin; D013386:Succinates; D008536:Meglumine