title: Differences in accuracy and underestimation rates for 14- versus 16-gauge core needle biopsies in ultrasound-detectable breast lesions.
abstract: OBJECTIVE
  Core needle biopsy (CNB) was widely used in the diagnosis of ultrasound-detectable breast lesions. We aimed at assessing the diagnostic performance differences between 14- and 16-gauge ultrasound-guided core biopsies.
  
  
  METHODS
  This retrospective study enrolled patients receiving CNB from January 2001 to December 2007. The results of 14- and 16-gauge breast CNBs were compared with pathology reports of open surgical biopsy (OSB).
  
  
  RESULTS
  A total of 1024 paired CNB and OSB results were obtained from 1732 CNB procedures in 1630 patients.Those CNB results reached 92.9% sensitivity, 99.7% specificity, 5.96% underestimation, and 94.8% accuracy rates. There was no difference in sensitivity (p=0.17) or specificity (p=0.38) between 14- and 16-gauge needles. However, better overall accuracy (p=0.02), less underestimation (p<0.001), and lower false-negative (p=0.02) rates were found for the 14-gauge CNB.
  
  
  CONCLUSIONS
  Regarding accuracy and underestimation rates, a 14-gauge needle is preferred to a 16-gauge one in ultrasound-guided biopsies.
authors.affiliation: Comprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Hung-Wen
authors.initials: HW
authors.lastname: Lai
authors.forename: Hwa-Koon
authors.initials: HK
authors.lastname: Wu
authors.forename: Shou-Jen
authors.initials: SJ
authors.lastname: Kuo
authors.forename: Shou-Tung
authors.initials: ST
authors.lastname: Chen
authors.forename: Hsin-Shun
authors.initials: HS
authors.lastname: Tseng
authors.forename: Ling-Ming
authors.initials: LM
authors.lastname: Tseng
authors.forename: Dar-Ren
authors.initials: DR
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D062005:Biopsy, Large-Core Needle / Q000295:instrumentation*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary; D055815:Young Adult