title: X-ray fluorescence tomographic system design and image reconstruction.
abstract: In this paper, we presented a new design of x-ray fluorescence CT imaging system. For detecting fuorescence signals of gold nanoparticles in-vivo, multiple spectroscopic detectors are arranged and rotated orthogonal to an excited region of interest so that a localized scan can be acquired with a maximized efficiency. Excitation filtration was employed to minimize the effects of low-energy x-rays and background scattering for lowering radiation dose to the object. Numerical simulations showed that the radiation dose is less than 300 mGy/second for a complete 30 views tomographic scan; and the sensitivity of 3D fluorescence signal detection is up to 0.2% contrast concentrations of nanoparticles. The x-ray fluorescence computed tomography is an important molecular imaging tool. It can be used directly in samall animal research. It has great translational potential for future clinical applications.
authors.affiliation: School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA, USA.
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Cong
authors.forename: Haiou
authors.initials: H
authors.lastname: Shen
authors.forename: Guohua
authors.initials: G
authors.lastname: Cao
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Ge
authors.initials: G
authors.lastname: Wang
mesh_terms: D003198:Computer Simulation; D006046:Gold / Q000737:chemistry; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry; D061848:Optical Imaging / Q000295:instrumentation* / Q000379:methods*; D019047:Phantoms, Imaging; D014057:Tomography, X-Ray Computed / Q000295:instrumentation* / Q000379:methods*
chemical_list: D006046:Gold