title: Reversible hypothalamic dysfunction in optic nerve germinoma.
abstract: Primary optic apparatus germ cell tumors are rare. There have been only 6 cases reported in the literature. Although they often disturb the hypothalamus-pituitary-adrenal axis and cause progressive visual loss, the influence of treatment outcomes on hypothalamic autoregulation has never been mentioned. Here, we report a patient with an optic nerve germinoma who presented with reversible visual and hypothalamic dysfunction, and we discuss the possible mechanisms and pathogenesis.
authors.affiliation: Department of Neurosurgery, China Medical University Hospital; and China Medical University, Taichung, Taiwan.
authors.forename: Chao-Hsuan
authors.initials: CH
authors.lastname: Chen
authors.forename: Hung-Lin
authors.initials: HL
authors.lastname: Lin
authors.forename: Der-Yang
authors.initials: DY
authors.lastname: Cho
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D018237:Germinoma / Q000150:complications / Q000175:diagnosis / Q000532:radiotherapy*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology*; D019574:Optic Nerve Neoplasms / Q000150:complications / Q000175:diagnosis / Q000532:radiotherapy*; D014786:Vision Disorders / Q000209:etiology; D055815:Young Adult