title: Radical cystectomy and orthotopic urinary diversion in male patients with pT4a urothelial bladder carcinoma: oncological outcomes.
abstract: The aim of the present study was to evaluate the oncological outcomes of radical cystectomy followed by orthotopic urinary diversion in male patients with urothelial bladder carcinoma involving prostatic stroma (pT4a). A total of 1964 patients with urothelial bladder carcinoma who underwent cystectomy between 1971 and 2008 were retrospectively analyzed. Among them, male patients with pT4aN0M0 disease at cystectomy and orthotopic urinary diversion were identified and included in the analysis. Exclusion criteria were perioperative mortality and primary urethrectomy. The outcomes were urethral recurrence, local recurrence, recurrence-free survival and overall survival. Univariate and log-rank statistics were used to examine associations between variables and outcome. A total of 33 patients (1.7%) entered the study with a median age of 71 years. Median follow up was 4.8 years (range 0.1-21 years). A total of two urethral recurrences (6%) occurred at a median of 2.4 years after cystectomy. No patient had local recurrence. The 5-year recurrence-free survival and overall survival was 56% ± 10% and 56% ± 9%, respectively. The probability of urethral and local recurrence after orthotopic diversion in pT4a urothelial bladder carcinoma patients is low. Thus, orthotopic urinary diversion appears to be oncologically safe in this patient population.
authors.affiliation: Norris Comprehensive Cancer Center, USC Institute of Urology, Los Angeles, California, USA.
authors.forename: Hooman
authors.initials: H
authors.lastname: Djaladat
authors.forename: Anirban P
authors.initials: AP
authors.lastname: Mitra
authors.forename: Gus
authors.initials: G
authors.lastname: Miranda
authors.forename: Eila C
authors.initials: EC
authors.lastname: Skinner
authors.forename: Siamak
authors.initials: S
authors.lastname: Daneshmand
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000401:mortality* / Q000601:surgery* / Q000628:therapy; D015653:Cystectomy / Q000379:methods / Q000401:mortality*; D016208:Databases, Factual; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000401:mortality* / Q000601:surgery* / Q000628:therapy; D014547:Urinary Diversion / Q000379:methods / Q000401:mortality*
keywords: cystectomy; urinary bladder neoplasm; urinary diversion