title: Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes.
abstract: Myleodysplastic syndromes (MDS) are pre-malignant hematopoietic diseases that can progress to acute myeloid leukemia (AML) progression in conjunction with changes in immune function. In this model of leukemia evolution, the expansion of immunosuppressive regulatory T cells (Tregs) contributes to immune escape. Here, we discuss the importance of Treg-memory phenotype switching as a poor prognostic indicator in MDS.
authors.affiliation: Immunology Program; H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL USA.
authors.forename: Adam W
authors.initials: AW
authors.lastname: Mailloux
authors.forename: Pearlie K
authors.initials: PK
authors.lastname: Epling-Burnette
keywords: immune escape; immunoediting; leukemia; myelodysplastic syndrome; regulatory T cells