title: Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma?
abstract: Resection of musculoskeletal sarcoma can result in large bone defects where regeneration is needed in a quantity far beyond the normal potential of self-healing. In many cases, these defects exhibit a limited intrinsic regenerative potential due to an adjuvant therapeutic regimen, seroma, or infection. Therefore, reconstruction of these defects is still one of the most demanding procedures in orthopaedic surgery. The constraints of common treatment strategies have triggered a need for new therapeutic concepts to design and engineer unparalleled structural and functioning bone grafts. To satisfy the need for long-term repair and good clinical outcome, a paradigm shift is needed from methods to replace tissues with inert medical devices to more biological approaches that focus on the repair and reconstruction of tissue structure and function. It is within this context that the field of bone tissue engineering can offer solutions to be implemented into surgical therapy concepts after resection of bone and soft tissue sarcoma. In this paper we will discuss the implementation of tissue engineering concepts into the clinical field of orthopaedic oncology.
authors.affiliation: Regenerative Medicine Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4049, Australia ; Department of Orthopaedic Surgery, König-Ludwig-Haus, Orthopaedic Center for Musculoskeletal Research, University of Würzburg, Brettreich Straße 11, 97072 Würzburg, Germany.
authors.forename: Boris Michael
authors.initials: BM
authors.lastname: Holzapfel
authors.forename: Mohit Prashant
authors.initials: MP
authors.lastname: Chhaya
authors.forename: Ferry Petrus Wilhelmus
authors.initials: FP
authors.lastname: Melchels
authors.forename: Nina Pauline
authors.initials: NP
authors.lastname: Holzapfel
authors.forename: Peter Michael
authors.initials: PM
authors.lastname: Prodinger
authors.forename: Ruediger
authors.initials: R
authors.lastname: von Eisenhart-Rothe
authors.forename: Martijn
authors.initials: M
authors.lastname: van Griensven
authors.forename: Jan-Thorsten
authors.initials: JT
authors.lastname: Schantz
authors.forename: Maximilian
authors.initials: M
authors.lastname: Rudert
authors.forename: Dietmar Werner
authors.initials: DW
authors.lastname: Hutmacher