title: [Comparative effectiveness study of local antioxidants in complex treatment of chronic periodontal disease].
abstract: Prospective, placebo-control, randomized blind study was carried out on the clinical effectiveness of the local administration of 1% emoxipine solution, 1,5% reamberin solution and 5% mexidol solution in patients with chronic periodontitis (CP). It was determined that all medications under study cause the decrease of simplified oral hygienic index by Green and Vermillion (OHI-S, Green J.C., Vermillion J.R., 1969), papillary-marginal-alveolar index (РМА, Parma C., 1960), papillary bleeding index (PBI, Saxer U.P., Muhlemann M.R., 1975) and increase the sialometry index in the case of CP. The best clinical effect was achieved by the local administration of reamberin, which turned out to be the only medication among those under study to lower the content of lipid peroxidation products in the mixed saliva, to decrease the periodontal index (PI, Russel A., 1956) and to result in the concomitant increase of life satisfaction index in patients with chronic periodontitis.
authors.forename: I A
authors.initials: IA
authors.lastname: Butiugin
authors.forename: N V
authors.initials: NV
authors.lastname: Kornilova
authors.forename: O V
authors.initials: OV
authors.lastname: Abramov
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000188:drug therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives / Q000627:therapeutic use; D009911:Oral Hygiene Index; D010847:Picolines / Q000627:therapeutic use; D013386:Succinates / Q000627:therapeutic use; D024505:Tocopherols / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D010847:Picolines; C549374:Reamberin; D013386:Succinates; C070020:emoxypine succinate; D008536:Meglumine; D024505:Tocopherols; C009820:6-methyl-2-ethyl-3-hydroxypyridine