title: The relationship between implant stability and bone health markers in post-menopausal women with bisphosphonate exposure.
abstract: OBJECTIVE
  The authors assessed the relationship between implant stability and bone turnover markers in patients with and without a history of bisphosphonate (BP) exposure for treatment of osteopenia/osteoporosis.
  
  
  METHODS
  One dental implant site was evaluated in 58 post-menopausal women with a spectrum of bone health in a "best practice" prospective cohort study. Each site had a previous or simultaneous bone augmentation procedure. BP exposure at enrollment was categorized as "never" or "past/current" exposure. Implant stability was assessed by resonance frequency analysis (RFA ISQ) at surgery and 8 weeks post-implant. Bone turnover markers, C-telopeptide collagen crosslinks (sCTX) and procollagen -1 N-terminal telopeptide (P1NP), were measured pre-treatment, 1, and 8 weeks following implant surgery.
  
  
  RESULTS
  Mean age was 62.4 ± 6.8 years; 66 % were osteopenic/osteoporotic. Average RFA ISQ at placement for all participants was 63.5 ± 11.3, at 8 weeks post-surgery 74.2 ± 9.4 (p < 0.01). Among "past/current" BP users, there was a significant negative correlation between RFA ISQ values at 8 weeks post-implant placement and sCTX and P1NP values at 1 week (ρ = -.65 and ρ = -.55, respectively; p < 0.01) and 8 weeks (ρ = -.64 and ρ = -.52, respectively; p < 0.05).
  
  
  CONCLUSIONS
  RFA ISQ values increased between implant placement and 8 weeks post-surgery demonstrating successful osseointegration. Lower bone turnover was associated with better implant stability among patients with a history of BP exposure.
  
  
  CONCLUSIONS
  Further investigation of the relationship between BP exposure and implant stability is warranted in a larger population, as results may strongly impact on clinical practice decisions.
authors.affiliation: University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030-5456, USA, taxel@nso.uchc.edu.
authors.forename: Pamela
authors.initials: P
authors.lastname: Taxel
authors.forename: Denise
authors.initials: D
authors.lastname: Ortiz
authors.forename: David
authors.initials: D
authors.lastname: Shafer
authors.forename: David
authors.initials: D
authors.lastname: Pendrys
authors.forename: Susan
authors.initials: S
authors.lastname: Reisine
authors.forename: Kandasamy
authors.initials: K
authors.lastname: Rengasamy
authors.forename: Martin
authors.initials: M
authors.lastname: Freilich
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D003758:Dental Implantation, Endosseous / Q000379:methods; D017268:Dental Prosthesis Retention; D019232:Dental Restoration Failure; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D017698:Postmenopause; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D004164:Diphosphonates