title: Bilateral lacrimal gland enlargement associated with isotretinoin treatment.
abstract: This report aims to raise awareness of the potential link between isotretinoin use and the development of lacrimal gland enlargement. A 23-year-old woman who was using isotretinoin 40 mg daily for acne vulgaris for 6 months presented with periocular pain and bilateral swelling of upper eyelids. She did not have any signs of inflammation. Her systemic workup including serological tests for autoimmune disorders were within normal limits. MRI of the orbits revealed bilateral enlargement of the lacrimal glands. Discontinuation of isotretinoin resulted in disappearance of her signs and symptoms and the size of the lacrimal glands reverted to normal after 2 months. Isotretinoin use may be associated with lacrimal gland enlargement, and this adverse effect seems to be transient and reversible on cessation of the drug.
authors.affiliation: Ocular Oncology Service, Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: Hayyam
authors.initials: H
authors.lastname: Kiratli
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Dikmetaş
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D001763:Blepharoptosis / Q000139:chemically induced; D003879:Dermatologic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D007765:Lacrimal Apparatus / Q000187:drug effects; D007766:Lacrimal Apparatus Diseases / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin