title: Guillain-Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c.
abstract: In this report, we present a case of a 50-year-old immunocompetent man with Guillain-Barré syndrome (GBS) associated with an autochthonous hepatitis E virus (HEV) infection. The patient presented with tetraparesis and elevated liver enzymes. HEV infection was confirmed serologically and by polymerase chain reaction (PCR) from blood and stool. Phylogenetic analysis revealed a novel HEV genotype 3 isolate closely related to other subgenotype 3c isolates from pig livers purchased in Germany. This indicates an autochthonous, potentially food-related hepatitis E and is, to our knowledge, the first report about a neurological syndrome associated with an HEV subgenotype 3c infection.
authors.affiliation: Department of Neurology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Scharn
authors.forename: T
authors.initials: T
authors.lastname: Ganzenmueller
authors.forename: J J
authors.initials: JJ
authors.lastname: Wenzel
authors.forename: R
authors.initials: R
authors.lastname: Dengler
authors.forename: A
authors.initials: A
authors.lastname: Heim
authors.forename: F
authors.initials: F
authors.lastname: Wegner
mesh_terms: D000818:Animals; D001769:Blood / Q000821:virology; D005243:Feces / Q000821:virology; D005838:Genotype; D005858:Germany; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000175:diagnosis*; D016751:Hepatitis E / Q000150:complications*; D016752:Hepatitis E virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011782:Quadriplegia / Q000175:diagnosis* / Q000209:etiology; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D012698:Serologic Tests
chemical_list: D012367:RNA, Viral