title: Inferior peripheral nonperfusion in bilateral diffuse uveal melanocytic proliferation.
abstract: Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a paraneoplastic syndrome characterized by cataract, photoreceptor loss and subretinal fluid overlying patchy areas of retinal pigment epithelium atrophy, and a diffusely thickened choroid with focal nodules. We present the case of a 64-year-old woman with a history of endometrial adenocarcinoma who developed BDUMP with bilateral exudative retinal detachments with inferior peripheral retinal ischemia. This new finding of peripheral nonperfusion expands the spectrum of BDUMP.
authors.affiliation: Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yonekawa
authors.forename: Yevgeniy
authors.initials: Y
authors.lastname: Shildkrot
authors.forename: Dean
authors.initials: D
authors.lastname: Eliott
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001284:Atrophy; D049109:Cell Proliferation; D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008544:Melanocytes / Q000473:pathology*; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use; D059545:Paraneoplastic Syndromes, Ocular / Q000175:diagnosis* / Q000188:drug therapy; D012163:Retinal Detachment / Q000175:diagnosis; D055213:Retinal Pigment Epithelium / Q000473:pathology; D041623:Tomography, Optical Coherence; D014057:Tomography, X-Ray Computed; D014603:Uveal Diseases / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel