title: Cardiometabolic consequences of gestational dysglycemia.
abstract: The development of gestational diabetes and even milder forms of dysglycemia during pregnancy represents a maternal phenotype at increased subsequent risk for developing type 2 diabetes mellitus, metabolic syndrome, and, with time, overt cardiovascular disease. A careful and systematic dissection of the hormonal, metabolic, and vascular changes occurring in such women during pregnancy and over the postpartum years provides a unique opportunity to identify conventional and novel conditions and biomarkers whose modification may attenuate adverse long-term outcomes, particularly cardiovascular risk. The purpose of this review is to summarize current understanding of the magnitude of such risk and its potential causes, with a particular focus on postpartum alterations in endothelial and vascular smooth muscle responsiveness.
authors.affiliation: Mount Sinai Hospital Department of Medicine, University of Toronto, Ontario, Canada.
authors.forename: Shireen
authors.initials: S
authors.lastname: Brewster
authors.forename: Bernard
authors.initials: B
authors.lastname: Zinman
authors.forename: Ravi
authors.initials: R
authors.lastname: Retnakaran
authors.forename: John S
authors.initials: JS
authors.lastname: Floras
mesh_terms: D052242:Adiponectin / Q000097:blood; D000465:Algorithms; D002318:Cardiovascular Diseases / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D044882:Glucose Metabolism Disorders / Q000503:physiopathology; D006801:Humans; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D052242:Adiponectin
keywords: AUC(gluc); BMI; CI; CVD; EDD; EID; FMD; GCT; GDM; GIGT; HR; NGT; NO; OGTT; OR; T2DM; area under the glucose curve; body mass index; cardiovascular disease; cardiovascular risk; confidence interval; endothelial function; endothelium-dependent dilation; endothelium-independent dilation; flow-mediated dilation; gestational diabetes; gestational diabetes mellitus; gestational impaired glucose tolerance; glucose challenge test; hazard ratio; nitric oxide; normal glucose tolerance; odds ratio; oral glucose tolerance test; type 2 diabetes mellitus