title: Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight.
abstract: OBJECTIVE
  Loss of BDNF-TrkB signaling results in obesity in both humans and mice; however, the neural circuit that mediates this effect is unknown. The role of TrkB signaling in dopamine-1 receptor expressing neurons in body weight regulation was tested.
  
  
  METHODS
  Mice with a floxed allele of the TrkB gene were paired with mice expressing Cre-recombinase under control of the D1 promoter to conditionally knock out expression of TrkB receptors from D1-neurons.
  
  
  RESULTS
  Deletion of TrkB receptors from D1 neurons results in obesity in chow fed mice due to increased feed efficiency. In contrast, loss of Trk B signaling in D1 neurons induced hyperphagia and hyperglycemia in mice maintained on high fat diet.
  
  
  CONCLUSIONS
  These findings indicate TrkB signaling in D1 neurons regulates body weight by distinct mechanisms for chow and high fat diet and may be important for defending the body against the development of obesity and obesity-related disorders.
authors.affiliation: Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Brittany L
authors.initials: BL
authors.lastname: Mason
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Lobo
authors.forename: Luis F
authors.initials: LF
authors.lastname: Parada
authors.forename: Michael
authors.initials: M
authors.lastname: Lutter
mesh_terms: D000818:Animals; D001069:Appetite Regulation / Q000235:genetics*; D001835:Body Weight / Q000235:genetics*; D059305:Diet, High-Fat; D004435:Eating / Q000235:genetics; D006963:Hyperphagia / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000378:metabolism*; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics; D020813:Receptor, trkB
chemical_list: D008562:Membrane Glycoproteins; D011505:Protein-Tyrosine Kinases; D017447:Receptors, Dopamine D1; C064371:Ntrk2 protein, mouse; D020813:Receptor, trkB