title: Positive end-expiratory pressure aggravates left ventricular diastolic relaxation further in patients with pre-existing relaxation abnormality.
abstract: BACKGROUND
  Positive end-expiratory pressure (PEEP) has been known to adversely influence cardiac output. Even though left ventricular (LV) diastolic function significantly contributes to LV performance, the effects of PEEP on LV diastolic function remains controversial. We, therefore, aimed to examine the effects of PEEP on LV diastolic function by use of pulsed wave Doppler tissue imaging in patients with pre-existing LV relaxation abnormality.
  
  
  METHODS
  Seventeen patients with peak early diastolic velocity of lateral mitral annulus (E') <8.5 cm s(-1) among patients who underwent coronary artery bypass graft surgery were evaluated. Echocardiographic and haemodynamic variables were measured with 0, 5, and 10 cmH2O of PEEP. E' and deceleration time (DT) of peak early transmitral filling velocity (E) were used as echocardiographic indicators of LV diastolic function.
  
  
  RESULTS
  Mean arterial blood pressure decreased during 10 cmH2O PEEP, compared with that during 0 cmH2O PEEP. E' showed a gradual and significant decrease with an incremental increase in PEEP (6.9 ± 0.9, 5.8 ± 0.9, and 5.2 ± 1.2 cm s(-1) during 0, 5, and 10 cmH2O PEEP, respectively), and DT of E was prolonged during 10 cmH2O PEEP, compared with that during 0 cmH2O PEEP.
  
  
  CONCLUSIONS
  Increasing PEEP led to a progressive decline in LV relaxation in patients with pre-existing LV relaxation abnormality.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap 2-dong, Songpa-gu, Seoul, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Chin
authors.forename: E H
authors.initials: EH
authors.lastname: Lee
authors.forename: W J
authors.initials: WJ
authors.lastname: Kim
authors.forename: D K
authors.initials: DK
authors.lastname: Choi
authors.forename: K D
authors.initials: KD
authors.lastname: Hahm
authors.forename: J Y
authors.initials: JY
authors.lastname: Sim
authors.forename: I C
authors.initials: IC
authors.lastname: Choi
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D062186:Arterial Pressure; D003971:Diastole; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology
keywords: echocardiography; heart, myocardial function; ventilation, positive end-expiratory pressure