title: Retinoic acid on stage in antitumor immunity.
abstract: The morphogenic role of retinoic acid (RA) in regulating immunity is underscored by our recent studies that show increased regional concentrations of RA and commensurate RA signaling in CD8+T cells within the tumor microenvironment. This study demonstrated for the first time that intrinsic RA signaling is required for tumor associated antigen (TAA)-specific CD8+T-cell survival and hence for tumor surveillance.
authors.affiliation: Department of Microbiology and Immunology; The Geisel School of Medicine; Dartmouth University; Lebanon, NH USA.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Guo
authors.forename: Randolph J
authors.initials: RJ
authors.lastname: Nolle
keywords: CD8+ T cell; anti-tumor immunity; retinoic acid; survival; tumor microenvironment