title: Tension-induced autophagy: may the chaperone be with you.
abstract: Impairment of autophagy in patients and animal models severely affects mechanically strained tissues such as skeletal muscle, heart, lung and kidney, leading for example to muscle dystrophy, cardiomyopathy and renal injury. However, the reason for this high reliance on autophagy remained largely elusive. Recent work in our lab now provides a possible explanation. We identified chaperone-assisted selective autophagy (CASA) as a tension-induced autophagy pathway essential for mechanotransduction in mammalian cells.
authors.affiliation: Institute for Cell Biology, University of Bonn, Bonn, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Ulbricht
authors.forename: Jörg
authors.initials: J
authors.lastname: Höhfeld
mesh_terms: D000818:Animals; D001343:Autophagy; D006801:Humans; D051379:Mice; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D018832:Molecular Chaperones
keywords: BAG3; CASA; Hsp70; WW domain; chaperone; mechanotransduction