title: Infantile hemangiomas treated by sequential application of pulsed dye laser and Nd:YAG laser radiation: a retrospective study.
abstract: OBJECTIVE
  Infantile hemangiomas are the most common benign tumor in children. They have 3 phases of development: a proliferative phase, an involuting phase, and involution. Although active treatment is often not required, it is necessary in some cases. Of the possible treatments for hemangiomas, lasers have been shown to be effective in all phases of development. We report our experience with dual-wavelength sequential pulses from a pulsed dye laser and an Nd:YAG laser.
  
  
  METHODS
  This was a retrospective, descriptive study of patients with infantile hemangioma in different phases of development treated with pulsed dye laser pulses followed by Nd:YAG laser pulses. Four dermatologists assessed the effectiveness of treatment on a scale of 10 to 0. Adverse effects and incidents related to treatment were recorded. The median and interquartile range were calculated as descriptive statistics. Pretreatment and posttreatment comparisons were performed using the Wilcoxon test.
  
  
  RESULTS
  Twenty-two patients with hemangiomas in different phases of development were included. A statistically significant improvement was obtained both for the entire group and for different subgroups. Posttreatment events were reported in 4 patients, and included edema and ulceration, skin atrophy, and hyperpigmentation.
  
  
  CONCLUSIONS
  We believe that treatment with dual-wavelength light from a pulsed dye laser and a Nd:YAG laser is a viable treatment option for infantile hemangiomas when first-line therapies are ineffective or contraindicated.
authors.affiliation: Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, Spain. jalcantarag@hotmail.es
authors.forename: J
authors.initials: J
authors.lastname: Alcántara-González
authors.forename: P
authors.initials: P
authors.lastname: Boixeda
authors.forename: M T
authors.initials: MT
authors.lastname: Truchuelo-Díez
authors.forename: B
authors.initials: B
authors.lastname: Pérez-García
authors.forename: L
authors.initials: L
authors.lastname: Alonso-Castro
authors.forename: P
authors.initials: P
authors.lastname: Jaén Olasolo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006391:Hemangioma / Q000601:surgery*; D006801:Humans; D007223:Infant; D054025:Lasers, Dye / Q000627:therapeutic use*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000601:surgery*