title: Comparison of oseltamivir and oseltamivir carboxylate concentrations in venous plasma, venous blood, and capillary blood in healthy volunteers.
abstract: Oseltamivir and oseltamivir carboxylate concentrations were measured in venous plasma, venous blood, and capillary blood taken simultaneously from 24 healthy volunteers. Median (range) venous-blood-to-plasma ratios were 1.42 (0.920 to 1.97) for oseltamivir and 0.673 (0.564 to 0.814) for oseltamivir carboxylate. Capillary blood/venous plasma ratios were 1.32 (0.737 to 3.16) for oseltamivir and 0.685 (0.502 to 1.34) for oseltamivir carboxylate. Oseltamivir concentrations in venous and capillary blood were similar. Oseltamivir carboxylate showed a time-dependent distribution between venous and capillary blood.
authors.affiliation: Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Insti
authors.initials: I
authors.lastname: Instiaty
authors.forename: Niklas
authors.initials: N
authors.lastname: Lindegardh
authors.forename: Podjanee
authors.initials: P
authors.lastname: Jittmala
authors.forename: Warunee
authors.initials: W
authors.lastname: Hanpithakpong
authors.forename: Daniel
authors.initials: D
authors.lastname: Blessborn
authors.forename: Sasithon
authors.initials: S
authors.lastname: Pukrittayakamee
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
authors.forename: Joel
authors.initials: J
authors.lastname: Tarning
mesh_terms: D000998:Antiviral Agents / Q000097:blood* / Q000493:pharmacokinetics*; D002196:Capillaries; D005260:Female; D006801:Humans; D008297:Male; D053139:Oseltamivir / Q000031:analogs & derivatives* / Q000097:blood* / Q000493:pharmacokinetics*; D010949:Plasma
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; C535162:oseltamivir carboxylate