title: Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer.
abstract: OBJECTIVE
  Altered expression of epithelial or stromal caveolin-1 (Cav-1) is observed in various types of human cancers. However, the clinical significance of Cav-1 expression in gastric cancer (GC) remains largely unknown. The present study aims to explore the clinicopathological significance and prognostic value of both tumor cells and cancer associated fibroblasts (CAFs) Cav-1 in GC.
  
  
  RESULTS
  Quantum dots immunofluorescence histochemistry was performed to examine the expression of Cav-1 in 20 cases of gastritis without intestinal metaplasia (IM), 20 cases of gastritis with IM and 286 cases of GC. Positive rates of epithelial Cav-1 in gastritis without IM, gastritis with IM and GC showed a decreasing trend (P = 0.012). Low expression of Cav-1 in CAFs but not in tumor cells was an independent predictor of poor prognosis in GC patients (P = 0.034 and 0.005 respectively in disease free survival and overall survival). Cav-1 level in tumor cells and CAFs showed no significant correlation with classic clinicopathological features.
  
  
  CONCLUSIONS
  Loss of epithelial Cav-1 may promote malignant progression and low CAFs Cav-1 level herald worse outcome of GC patient, suggesting CAFs Cav-1 may be a candidate therapeutic target and a useful prognostic marker of GC.
authors.affiliation: Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, P. R. China.
authors.forename: Xianda
authors.initials: X
authors.lastname: Zhao
authors.forename: Yuyu
authors.initials: Y
authors.lastname: He
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Lifang
authors.initials: L
authors.lastname: Fan
authors.forename: Zonghuan
authors.initials: Z
authors.lastname: Li
authors.forename: Guifang
authors.initials: G
authors.lastname: Yang
authors.forename: Honglei
authors.initials: H
authors.lastname: Chen
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D051242:Caveolin 1 / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D011485:Protein Binding; D012372:ROC Curve; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D055815:Young Adult
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D014408:Biomarkers, Tumor; D051242:Caveolin 1