title: The dedifferentiation of neuroendocrine tumor metastases: myth or reality?
abstract: Dedifferentiation is a process that may be found in metastasis from the neuroendocrine tumors. We present the case of a female within the seventh decade of life incidentally diagnosed with a mature teratoma with element of cartilages, bronchia, mucinous glands, and a poorly differentiated neuroendocrine carcinoma (Ki67 of 30%). After six months of chemotherapy and another six months of disease free interval, a metastasis of the great omentum was removed. The dedifferentiation was diagnosed based on much higher Ki67 (of 70%). The loss of estrogen receptor of 40% from the initial site to 3% into metastasis indicates an exclusive neuroendocrine aggressive pattern. The ovarian carcinoid is a rare situation, and metastasis to the great omentum with dedifferentiation is even seldom.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Cătălina
authors.initials: C
authors.lastname: Poiană
authors.forename: M C
authors.initials: MC
authors.lastname: Neamţu
authors.forename: Elena Taina
authors.initials: ET
authors.lastname: Avramescu
authors.forename: Mara
authors.initials: M
authors.lastname: Carşote
authors.forename: Raluca
authors.initials: R
authors.lastname: Trifănescu
authors.forename: Dana
authors.initials: D
authors.lastname: Terzea
authors.forename: Oana Maria
authors.initials: OM
authors.lastname: Neamţu
authors.forename: Rucsandra
authors.initials: R
authors.lastname: Dănciulescu Miulescu
mesh_terms: D000368:Aged; D002276:Carcinoid Tumor / Q000175:diagnosis / Q000473:pathology; D054337:Cell Dedifferentiation / Q000502:physiology; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013724:Teratoma / Q000175:diagnosis / Q000473:pathology