title: Interactions of CT-DNA with Hypocrellin A and its Al(3+)-Hypocrellin A complex.
abstract: In this study, the chelation of Hypocrellin A (HA) with Al(3+) in water solution has been synthesized, and the interactions of HA and Al(3+)-HA complex with calf thymus DNA are in detail compared by UV-vis and fluorescence spectroscopic techniques, circular dichroism spectroscopy and viscosity measurement. The experiment results suggest that HA and Al(3+)-HA complex both could bind to CT DNA by intercalation mode, and double helix of DNA was damaged. Moreover, Al(3+)-HA complex not only displays higher absorption at therapeutic window but also displays stronger binding affinity to CT DNA than HA.
authors.affiliation: Analysis and Testing Center, School of Geograph Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210046, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ma
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Ge
authors.forename: Heyong
authors.initials: H
authors.lastname: Huang
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.forename: Lina
authors.initials: L
authors.lastname: Han
authors.forename: Jiahong
authors.initials: J
authors.lastname: Zhou
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Yang
mesh_terms: D000535:Aluminum / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D002942:Circular Dichroism; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D009690:Nucleic Acid Conformation / Q000187:drug effects; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D019800:Phenol; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D011809:Quinones / Q000737:chemistry / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D056831:Coordination Complexes; D004365:Drugs, Chinese Herbal; D017319:Photosensitizing Agents; D011809:Quinones; D019800:Phenol; D010569:Perylene; D004247:DNA; C427203:calf thymus DNA; D000535:Aluminum; C048388:hypocrellin A