title: [Application of TNF-alpha blocker concentration assays in the treatment of inflammatory bowel diseases].
abstract: Application of TNF-alpha blocker concentration assays in the treatment of inflammatory bowel diseases Concentration assays for the biological drugs infliximab and adalimumab have proven useful in optimizing drug therapy in inflammatory bowel diseases as well as in rheumatic diseases. Drug dosing can be controlled and a better response strived for by determining the drug level especially in cases of unsatisfactory treatment response. To support the treatment decision, antibody assays of biological drug therapy seem to be beneficial when contemplating a change of medication.
authors.affiliation: HYKS, Meilahden sairaala, gastroenterologian klinikka.
authors.forename: Taina
authors.initials: T
authors.lastname: Sipponen
authors.forename: Kaija-leena
authors.initials: KL
authors.lastname: Kolho
mesh_terms: D000068879:Adalimumab; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D000069285:Infliximab; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D005765:Gastrointestinal Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D000068879:Adalimumab