title: Sex-associated expression of co-stimulatory molecules CD80, CD86, and accessory molecules, PDL-1, PDL-2 and MHC-II, in F480+ macrophages during murine cysticercosis.
abstract: Macrophages are critically involved in the interaction between T. crassiceps and the murine host immune system. Also, a strong gender-associated susceptibility to murine cysticercosis has been reported. Here, we examined the sex-associated expression of molecules MHC-II, CD80, CD86, PD-L1, and PD-L2 on peritoneal F4/80(hi) macrophages of BALB/c mice infected with Taenia crassiceps. Peritoneal macrophages from both sexes of mice were exposed to T. crassiceps total extract (TcEx). BALB/c Females mice recruit higher number of macrophages to the peritoneum. Macrophages from infected animals show increased expression of PDL2 and CD80 that was dependent from the sex of the host. These findings suggest that macrophage recruitment at early time points during T. crassiceps infection is a possible mechanism that underlies the differential sex-associated susceptibility displayed by the mouse gender.
authors.affiliation: Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, 04510 México, DF, Mexico.
authors.forename: Cristián
authors.initials: C
authors.lastname: Togno-Peirce
authors.forename: Karen
authors.initials: K
authors.lastname: Nava-Castro
authors.forename: Luis Ignacio
authors.initials: LI
authors.lastname: Terrazas
authors.forename: Jorge
authors.initials: J
authors.lastname: Morales-Montor
mesh_terms: D000818:Animals; D018122:B7-1 Antigen / Q000276:immunology / Q000378:metabolism*; D051940:B7-2 Antigen / Q000276:immunology / Q000378:metabolism*; D060890:B7-H1 Antigen / Q000378:metabolism*; D003551:Cysticercosis / Q000276:immunology / Q000378:metabolism* / Q000469:parasitology; D004198:Disease Susceptibility; D005260:Female; D005786:Gene Expression Regulation; D006183:H-2 Antigens / Q000378:metabolism*; D008262:Macrophage Activation / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000276:immunology / Q000378:metabolism*; D008297:Male; D051379:Mice; D061027:Programmed Cell Death 1 Ligand 2 Protein / Q000378:metabolism*; D012727:Sex Characteristics; D013621:Taenia / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity
chemical_list: D018122:B7-1 Antigen; D051940:B7-2 Antigen; D060890:B7-H1 Antigen; C497965:Cd86 protein, mouse; D006183:H-2 Antigens; C556978:Pdcd1lg2 protein, mouse; D061027:Programmed Cell Death 1 Ligand 2 Protein