title: Different mechanisms regulate productive herpes simplex virus 1 (HSV-1) and HSV-2 infections in adult trigeminal neurons.
abstract: Herpes simplex virus 1 (HSV-1) and HSV-2 establish latency in different neuronal subtypes (A5+ and KH10+) in murine trigeminal ganglia, results which correlate with restricted productive infection in these neurons in vitro. HSV-2 latency-associated transcript (LAT) contains a cis-acting regulatory element near the transcription start site that promotes productive infection in A5+ neurons and a second element in exon 1 that inhibits productive infection in KH10+ neurons. HSV-1 contains no such regulatory sequences, demonstrating different mechanisms for regulating productive HSV infection in neurons.
authors.affiliation: F.I. Proctor Foundation and Department of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Bertke
authors.forename: AyeAye
authors.initials: A
authors.lastname: Ma
authors.forename: Mathew S
authors.initials: MS
authors.lastname: Margolis
authors.forename: Todd P
authors.initials: TP
authors.lastname: Margolis
mesh_terms: D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D015967:Gene Expression Regulation, Viral; D006561:Herpes Simplex / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000235:genetics* / Q000502:physiology; D018258:Herpesvirus 2, Human / Q000235:genetics* / Q000502:physiology; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009474:Neurons / Q000821:virology*; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D012668:Trigeminal Ganglion / Q000166:cytology / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D017735:Virus Latency
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins