title: Evaluation of constituents of Piper retrofractum fruits on neurotrophic activity.
abstract: Three new compounds, 1-3, together with 22 known compounds, were isolated from the fruits of Piper retrofractum. The structures of the new compounds were elucidated on the basis of spectroscopic data analysis and comparison with literature values. Compound 1 was found to enhance the neurite outgrowth of NGF-mediated PC12 cells at concentrations ranging from 0.1 to 10 μM.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan. miwa-k@ph.bunri-u.ac.jp
authors.forename: Miwa
authors.initials: M
authors.lastname: Kubo
authors.forename: Rina
authors.initials: R
authors.lastname: Ishii
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ishino
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Matsui
authors.forename: Masaaki
authors.initials: M
authors.lastname: Akagi
authors.forename: Eishin
authors.initials: E
authors.lastname: Kato
authors.forename: Shinya
authors.initials: S
authors.lastname: Hosoda
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Fukuyama
mesh_terms: D000818:Animals; D005638:Fruit / Q000737:chemistry; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000187:drug effects; D016501:Neurites / Q000187:drug effects; D031701:Piper / Q000737:chemistry*; D051381:Rats; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D009414:Nerve Growth Factors; D013729:Terpenes; C582679:indotertine B