title: [Mammographic screening with the assessment of risk factors and incidence of BRCA-associated breast cancer in the Republic of India].
abstract: The leading risk factors of breast cancer (BC) were found to affect the efficiency of mammographic screening. The BC screening covered 26 912 women in 2001-2010. Its risk factors were identified using a questionnaire survey. During the BC screening, all the women underwent mammography in the frontal and oblique projections. The BIRADS scale was used to evaluate breast X-ray density. The performed examination revealed that the number of risk factors for BC directly affected its stage. The diagnostic efficiency of screening mammography was found to decline in the groups of patients with high breast X-ray density. The paper provides evidence that it is important to monitor groups of patients having BC risk factors and that it is expedient to estimate breast X-ray density. The frequency of BRCA1/2 gene mutations was determined in patients with BC identified during the mammographic screening. A relationship was found between the diagnosis of end-stage BC and the presence of BRCA1/2 gene mutations.
authors.forename: S K
authors.initials: SK
authors.lastname: Ternovoĭ
authors.forename: S
authors.initials: S
authors.lastname: Matkhev
authors.forename: N V
authors.initials: NV
authors.lastname: Meladze
authors.forename: A E
authors.initials: AE
authors.lastname: Solopova
authors.forename: A B
authors.initials: AB
authors.lastname: Abduraimov
authors.forename: K A
authors.initials: KA
authors.lastname: Les'ko
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008327:Mammography / Q000379:methods*; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009154:Mutation; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
chemical_list: D004273:DNA, Neoplasm