title: Ulcers caused by bullous morphea: successful therapy with N-acetylcysteine and topical wound care.
abstract: Bullous morphea is an uncommon form of localized scleroderma. The pathogenesis is unknown and treatment of coexistent ulcers is difficult. The pathogenesis of bullae formation in morphea is multifactorial, but reactive oxygen species production appears to play a key role. We report a patient with bullous morphea with long-standing ulcers whom we successfully treated with N-acetylcysteine and topical wound care. N-acetylcysteine, an antioxidant sulfhydryl substance, promotes the healing of ulcers in patients with bullous morphea.
authors.forename: E
authors.initials: E
authors.lastname: Rosato
authors.forename: M L
authors.initials: ML
authors.lastname: Veneziano
authors.forename: A
authors.initials: A
authors.lastname: Di Mario
authors.forename: I
authors.initials: I
authors.lastname: Molinaro
authors.forename: S
authors.initials: S
authors.lastname: Pisarri
authors.forename: F
authors.initials: F
authors.lastname: Salsano
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use*; D000287:Administration, Topical; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage; D000077325:Ringer's Lactate; D012594:Scleroderma, Localized / Q000150:complications / Q000628:therapy*; D017592:Skin Care / Q000379:methods; D014456:Ulcer / Q000209:etiology / Q000628:therapy*; D014945:Wound Healing
chemical_list: D000975:Antioxidants; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D000111:Acetylcysteine