title: Meat, milk and risk of lymphoid malignancies: a case-control study in Uruguay.
abstract: In the time period 1996-2004, 697 cases with lymphoid neoplasms and 3606 controls with nonneoplastic conditions were included in a case-control study conducted in the Cancer Institute of Uruguay. They were administered a routine questionnaire that included 8 sections and a food frequency questionnaire focused on intakes of total meat, red meat, salted meat, barbecued meat, processed meat, milk, total vegetables and total fruits, and alcoholic beverages. Lymphoid cancers were analyzed by multiple polytomous regression. Red meat, salted meat, and milk were positively associated with risk of lymphoid cancers [odds ratios (OR) for the highest tertile vs. the lowest one of red meat = 1.68, 95% confidence interval (CI) 1.37-2.08, OR for whole milk = 2.92, 95% CI 2.63-3.63). On the other hand, plant foods, particularly total fruits, and alcoholic beverages (mainly red wine) were protective. We could conclude that these foods could play a significant role in the etiology of lymphoid malignancies.
authors.affiliation: Department of Pathology, School of Medicine, University of the Republic, Montevideo, Uruguay. edestefani@gmail.com
authors.forename: Eduardo
authors.initials: E
authors.lastname: De Stefani
authors.forename: Alvaro L
authors.initials: AL
authors.lastname: Ronco
authors.forename: Hugo
authors.initials: H
authors.lastname: Deneo-Pellegrini
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Pelayo
authors.initials: P
authors.lastname: Correa
authors.forename: Enrique
authors.initials: E
authors.lastname: Barrios
authors.forename: Gisele
authors.initials: G
authors.lastname: Acosta
authors.forename: María
authors.initials: M
authors.lastname: Mendilaharsu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000434:Alcoholic Beverages; D000818:Animals; D016022:Case-Control Studies; D005260:Female; D005511:Food Handling / Q000379:methods; D005638:Fruit; D006689:Hodgkin Disease / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000453:epidemiology / Q000209:etiology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000209:etiology; D008232:Lymphoproliferative Disorders / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008460:Meat; D008461:Meat Products; D008875:Middle Aged; D008892:Milk; D009101:Multiple Myeloma / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014583:Uruguay / Q000453:epidemiology; D014675:Vegetables; D014920:Wine