title: Peach allergy in Spanish children: tolerance to the pulp and molecular sensitization profile.
abstract: BACKGROUND
  Peach allergy is the main cause of vegetable food allergy in the Mediterranean area. Pru p 3 is the major allergen, and it is mainly found in the peel.
  
  
  OBJECTIVE
  We sought to calculate the frequency of tolerance to peach pulp in Spanish children suffering from allergic reactions after eating or having contact with peach and to analyze the sensitization pattern to peach allergens.
  
  
  METHODS
  Fifty-seven children (32 boys; median age, 7.4 yr) were included in the study. A systematized questionnaire on allergic reactions to peach was administered. Prick tests with peach peel and pulp, peach lipid transfer protein (LTP), and profilin were performed. Serum-specific IgE to peach, rPru p 1, rPru p 3, and rPru p 4 was determined by ImmunoCAP. Oral food challenges (OFCs) with peach pulp were performed on all but one child.
  
  
  RESULTS
  Eighty-eight percent of the children had positive prick tests with peach peel, 35% with peach pulp, 88% with peach LTP, and 9% with profilin. Serum-specific IgE to peach was demonstrated in 100% of the patients; rPru p 3-specific IgE in 96%; rPru p 1-specific IgE in 11%; and rPru p 4-specific IgE in 10%. Oral food challenge was negative in 52 (93%) children.
  
  
  CONCLUSIONS
  More than 90% of the study population tolerated peeled peach. Pru p 3 was the major allergen. Pru p 1 and 4 showed low prevalence.
authors.affiliation: Department of Allergy, Hospital La Paz Health Research Institute (IdiPaz), Madrid, Spain. med012396@saludalia.com
authors.forename: Teresa
authors.initials: T
authors.lastname: Boyano-Martínez
authors.forename: María
authors.initials: M
authors.lastname: Pedrosa
authors.forename: Teresa
authors.initials: T
authors.lastname: Belver
authors.forename: Santiago
authors.initials: S
authors.lastname: Quirce
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Ara
mesh_terms: D000293:Adolescent; D052179:Antigens, Plant / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004311:Double-Blind Method; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D005638:Fruit / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests; D008297:Male; D010940:Plant Proteins / Q000276:immunology*; D051304:Profilins / Q000276:immunology; D011446:Prospective Studies; D027861:Prunus / Q000276:immunology*; D013030:Spain; D011795:Surveys and Questionnaires
chemical_list: D052179:Antigens, Plant; D015415:Biomarkers; D002352:Carrier Proteins; D010940:Plant Proteins; D051304:Profilins; C403252:Pru p 1 allergen; C463181:Pru p 3 allergen; C572509:Pru p 4 allergen, Prunus persica; C511920:lipid transfer proteins, plant; D007073:Immunoglobulin E