title: Orally inhaled fluticasone propionate improved chronic rhinosinusitis with co-morbid asthma: report of a case.
abstract: Chronic rhinosinusitis and asthma are expressions of airway inflammatory diseases that frequently coexist, especially in the case of adult-onset asthma. Both conditions have similar pathological features, while one affects the upper airways and the other the lower airways. Whether the treatment of bronchial inflammation affects the severity of sinus disease remains an unanswered question. We report a case of refractory chronic rhinosinusitis with co-morbid adult-onset asthma that effectively improved upon treatment with a daily dose of 200 μg (100 μg b.i.d.) of inhaled fluticasone propionate (FP).
authors.affiliation: Department of Otolaryngology, Tokyo Women's Medical University of Medicine, Tokyo, Japan. nonaka-m@oto.twmu.ac.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Nonaka
authors.forename: Yukako
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Ruby
authors.initials: R
authors.lastname: Pawankar
authors.forename: Toshio
authors.initials: T
authors.lastname: Yoshihara
mesh_terms: D000280:Administration, Inhalation; D000730:Androstadienes / Q000008:administration & dosage*; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008875:Middle Aged; D012220:Rhinitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D012852:Sinusitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000730:Androstadienes; D001993:Bronchodilator Agents; D000068298:Fluticasone