title: Are preoperative Kattan and Stephenson nomograms predicting biochemical recurrence after radical prostatectomy applicable in the Chinese population?
abstract: OBJECTIVE
  Kattan and Stephenson nomograms are based on the outcomes of patients with prostate cancer recruited in the USA, but their applicability to Chinese patients is yet to be validated. We aim at studying the predictive accuracy of these nomograms in the Chinese population.
  
  
  METHODS
  A total of 408 patients who underwent laparoscopic or open radical resection of prostate from 1995 to 2009 were recruited. The preoperative clinical parameters of these patients were collected, and they were followed up regularly with PSA monitored. Biochemical recurrence was defined as two or more consecutive PSA levels >0.4 ng/mL after radical resection of prostate or secondary cancer treatment.
  
  
  RESULTS
  The overall observed 5-year and 10-year biochemical recurrence-free survival rates were 68.3% and 59.8%, which was similar to the predicted values by the Kattan and Stephenson nomograms, respectively. The results of our study achieved a good concordance with both nomograms (Kattan: 5-years, 0.64; Stephenson: 5-years, 0.62, 10-years, 0.71).
  
  
  CONCLUSIONS
  The incidence of prostate cancer in Hong Kong is increasing together with the patients' awareness of this disease. Despite the fact that Kattan nomograms were derived from the western population, it has been validated in our study to be useful in Chinese patients as well.
authors.affiliation: Division of Urology, Department of Surgery, Queen Elizabeth Hospital, Hong Kong, China. yeesung@gmail.com
authors.forename: Victor H W
authors.initials: VH
authors.lastname: Yeung
authors.forename: Yi
authors.initials: Y
authors.lastname: Chiu
authors.forename: Sylvia S Y
authors.initials: SS
authors.lastname: Yu
authors.forename: W H
authors.initials: WH
authors.lastname: Au
authors.forename: Steve W H
authors.initials: SW
authors.lastname: Chan
mesh_terms: D044466:Asian People; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007610:Kallikreins / Q000032:analysis; D053208:Kaplan-Meier Estimate; D008297:Male; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D049451:Nomograms; D011237:Predictive Value of Tests; D057234:Preoperative Period; D017430:Prostate-Specific Antigen / Q000032:analysis; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism
chemical_list: C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen