title: [Haplotype frequency and mutation of 17 Y-STR loci in Han population in Guangdong Province].
abstract: OBJECTIVE
  To investigate the polymorphisms of 17 Y-STR loci in Han population in Guangdong Province and explore its application in forensic medicine.
  
  
  METHODS
  Seventeen Y-STR loci (DYS19, DYS385a/b, DYS635, DYS389I, DYS389II,DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, Y-GATA-H4) were analyzed using Y filer™ kit in 1000 unrelated individuals and 1000 DNA-confirmed father-son pairs. All mutations were confirmed by DNA sequence analysis.
  
  
  RESULTS
  No shared haplotypes were observed among the 1000 unrelated male individuals, and the gene diversity of 17 Y-STR loci ranged from 0.4285 (DYS391) to 0.9654 (DYS385a/b). The samples yielded an overall haplotype diversity of 1.000. A total of 17000 meiotic events were investigated in 1000 father-son pairs with DNA-confirmed biological paternity and 46 differences were observed between the fathers and sons. The average mutation rate was 0.0027 (95%CI, 0.0020-0.0036) per locus.
  
  
  CONCLUSIONS
  The 17 Y-STR loci included in Y-filer have high genetic polymorphisms in South China Han population and have good prospect for application in forensic medicine.
authors.affiliation: Department of Forensic Medicine, Southern Medical University, Guangzhou 510515, China. weixia_weng@hotmail.com
authors.forename: Weixia
authors.initials: W
authors.lastname: Weng
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Shuanglin
authors.initials: S
authors.lastname: Li
authors.forename: Changhui
authors.initials: C
authors.lastname: Liu
authors.forename: Huijun
authors.initials: H
authors.lastname: Wang
mesh_terms: D002681:China; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic