title: A click-activated fluorescent probe for selective detection of hydrazoic acid and its application in biological imaging.
abstract: Here we present a new approach to aqueous hydrazoic acid detection through the synthesis and evaluation of an alkyne-based fluorescent probe, which could be applied in the monitoring of hydrazoic acid in both living Hela cells and larval zebrafish. This probe can also serve as an early warning automaton which would alert when both azide and protons exist over the threshold value.
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering and College of Science, Nanjing University of Technology, Nanjing 210009, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Yao
authors.forename: Qi
authors.initials: Q
authors.lastname: Qi
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.forename: Jing-Yun
authors.initials: JY
authors.lastname: Li
authors.forename: Cheng
authors.initials: C
authors.lastname: Yao
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000818:Animals; D001386:Azides / Q000032:analysis* / Q000737:chemistry; D057930:Click Chemistry; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015027:Zebrafish
chemical_list: D000480:Alkynes; D001386:Azides; D005456:Fluorescent Dyes; C007972:hydrazoic acid