title: [Additional indicators of the assessment of efficacy of disease modifying drugs (preliminary results)].
abstract: The working experience of the Moscow oblast center for multiple sclerosis is analyzed. Along with standard methods of treatment efficacy evaluation, a cytokines (tumor necrosis factor alpha, gamma-interferon, interleukins 10 and 17) measurement, a morphological study of CD4 and CD8 lymphocytes with cell microelectrophoresis, a complex of morphometric and optic cell parameters using laser computed phase-interference microscopy and cell optic coherent tomography of the eye's retina are used. Preliminary results of the efficacy of these methods are presented.
authors.forename: T I
authors.initials: TI
authors.lastname: Iakushina
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Lizhdvoĭ
authors.forename: I A
authors.initials: IA
authors.lastname: Vasilenko
authors.forename: O M
authors.initials: OM
authors.lastname: Andriukhina
authors.forename: S V
authors.initials: SV
authors.lastname: Kotov
mesh_terms: D001921:Brain / Q000473:pathology; D016207:Cytokines / Q000097:blood*; D004359:Drug Therapy, Combination; D000068876:Fingolimod Hydrochloride; D005500:Follow-Up Studies; D000068717:Glatiramer Acetate; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016899:Interferon-beta / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D010455:Peptides / Q000627:therapeutic use*; D011409:Propylene Glycols / Q000627:therapeutic use*; D055502:Secondary Prevention; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D010455:Peptides; D011409:Propylene Glycols; D000068717:Glatiramer Acetate; D016899:Interferon-beta; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine