title: Composition, in-vitro anticancer, and antimicrobial activities of the leaf essential oil of Machilus mushaensis from Taiwan.
abstract: This study investigated the chemical composition, in-vitro anticancer, and antimicrobial activities of the essential oil isolated from the leaf of Machilus mushaensis from Taiwan. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Forty compounds were identified, representing 100% of the oil. The main components identified were n-decanal (61.0%), and alpha-cadinol (20.8%). The oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells. The antimicrobial activity of the oil was tested by the disc diffusion and micro-broth dilution methods against ten microbial species. The oil exhibited moderate growth suppression against Gram-positive bacteria and yeast with inhibition zones of 25-29 mm to MIC values of 375-500 microg/mL, respectively. alpha-Cadinol was found to show promising anticancer and antimicrobial activities.
authors.affiliation: Department of Forestry, National Chung Hsing University, 250 Kuo Kuang Rd., Taichung, Taiwan 402.
authors.forename: Yu-Chang
authors.initials: YC
authors.lastname: Su
authors.forename: Chen-Lung
authors.initials: CL
authors.lastname: Ho
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D019770:Lauraceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000032:analysis* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013624:Taiwan
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile