title: [The first results of a combined all-Russian study on clinical genetics of multiple sclerosis].
abstract: Multiple sclerosis is a classic multifactorial disease in which etiology interaction of external factors and structural features of a large number of genes plays an important role. Identifying risk factors for multiple sclerosis and creating an integrated model of pathogenesis are urgent tasks of neurology. Revealing true risk factors is possible only in studies with sufficient statistical power, so with a large amount of samples. We conducted the association study of CD40 gene's polymorphisms and multiple sclerosis among residents of the Russian Federation. The results demonstrated the need to combine data from different researchers in clinical studies to increase the power of the study.
authors.forename: E A
authors.initials: EA
authors.lastname: Sokolova
authors.forename: N A
authors.initials: NA
authors.lastname: Malkova
authors.forename: D S
authors.initials: DS
authors.lastname: Korobko
authors.forename: A S
authors.initials: AS
authors.lastname: Rozhdestvenskiĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Kakulia
authors.forename: E V
authors.initials: EV
authors.lastname: Khanokh
authors.forename: R A
authors.initials: RA
authors.lastname: Delov
authors.forename: F A
authors.initials: FA
authors.lastname: Platonov
authors.forename: T E
authors.initials: TE
authors.lastname: Popova
authors.forename: E G
authors.initials: EG
authors.lastname: Aref'eva
authors.forename: N N
authors.initials: NN
authors.lastname: Zagorskaia
authors.forename: V M
authors.initials: VM
authors.lastname: Alifirova
authors.forename: M A
authors.initials: MA
authors.lastname: Titova
authors.forename: I V
authors.initials: IV
authors.lastname: Smagina
authors.forename: S A
authors.initials: SA
authors.lastname: El'chaninova
authors.forename: A V
authors.initials: AV
authors.lastname: Popovtseva
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Lichenko
authors.forename: M A
authors.initials: MA
authors.lastname: Dymova
authors.forename: A S
authors.initials: AS
authors.lastname: Vaĭner
authors.forename: O V
authors.initials: OV
authors.lastname: P'iankova
authors.forename: I P
authors.initials: IP
authors.lastname: Oskorbin
authors.forename: A A
authors.initials: AA
authors.lastname: Kechin
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
authors.forename: O G
authors.initials: OG
authors.lastname: Kulakova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Tsareva
authors.forename: O O
authors.initials: OO
authors.lastname: Favorova
authors.forename: S G
authors.initials: SG
authors.lastname: Shur
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Lashch
authors.forename: N F
authors.initials: NF
authors.lastname: Popova
authors.forename: E I
authors.initials: EI
authors.lastname: Gusev
authors.forename: A N
authors.initials: AN
authors.lastname: Boĭko
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Aul'chenko
authors.forename: M L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D000328:Adult; D000483:Alleles; D019013:CD40 Antigens / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology
chemical_list: D019013:CD40 Antigens; D004247:DNA