title: Relationship between diffusion tensor fractional anisotropy and motor outcome in patients with hemiparesis after corona radiata infarct.
abstract: This study examined the relationship between fractional anisotropy (FA) values of magnetic resonance-diffusion tensor imaging (DTI) and motor outcome (1 month after onset) in 15 patients with hemiparesis after ischemic stroke of corona radiata lesions. DTI data were obtained on days 14-18. FA values within the cerebral peduncle were analyzed using a computer-automated method. Motor outcome of hemiparesis was evaluated according to Brunnstrom stage (BRS; 6-point scale: severe to normal) for separate shoulder/elbow/forearm, wrist/hand, and lower extremity functions. The ratio of FA values in the affected hemisphere to those in the unaffected hemisphere (rFA) was assessed in relation to the BRS data (Spearman rank correlation test, P<.05). rFA values ranged from .715 to 1.002 (median=.924). BRS ranged from 1 to 6 (median=4) for shoulder/elbow/forearm, from 1 to 6 (median=5) for wrist/hand, and from 2 to 6 (median=4) for the lower extremities. Analysis revealed statistically significant relationships between rFA and upper extremity functions (correlation coefficient=.679 for shoulder/elbow/forearm and .706 for wrist/hand). Although slightly less evident, the relationship between rFA and lower extremity function was also statistically significant (correlation coefficient=.641). FA values within the cerebral peduncle are moderately associated with the outcome of both upper and lower extremity functions, suggesting that DTI may be applicable for outcome prediction in stroke patients with corona radiata infarct.
authors.affiliation: Department of Rehabilitation Medicine, Nishinomiya Kyoritsu Neurosurgical Hospital, Nishinomiya, Hyogo; Department of Physical Medicine and Rehabilitation, Hyogo College of Medicine, Nishinomiya, Hyogo. Electronic address: koyama.t@nk-hospital.or.jp.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Koyama
authors.forename: Kohei
authors.initials: K
authors.lastname: Marumoto
authors.forename: Hiroji
authors.initials: H
authors.lastname: Miyake
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Domen
mesh_terms: D000368:Aged; D016880:Anisotropy; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002544:Cerebral Infarction / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D065850:Cerebral Peduncle / Q000473:pathology; D056324:Diffusion Tensor Imaging; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D010291:Paresis / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D020127:Recovery of Function; D020521:Stroke / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome
keywords: Ischemia; paresis; prognosis; recovery; stroke