title: One-pot tandem cyclization of enantiopure asymmetric cis-2,5-disubstituted pyrrolidines: Facile access to chiral 10-heteroazatriquinanes.
abstract: A series of chiral 10-heteroazatriquinanes were synthesized from enantiopure asymmetric cis-2,5-disubstituted pyrrolidines through a one-pot tandem cyclization procedure. The structures and configurations of these new chiral 10-heteroazatriquinanes are confirmed by X-ray single-crystal diffraction analysis.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, The Fourth Military Medical University, Changle Xilu 17, Xi-An, 710032, P. R. China.
authors.forename: Ping-An
authors.initials: PA
authors.lastname: Wang
authors.forename: Sheng-Yong
authors.initials: SY
authors.lastname: Zhang
authors.forename: Henri B
authors.initials: HB
authors.lastname: Kagan
keywords: 10-heteroazatriquinane; X-ray single-crystal diffraction analysis; cis-2,5-disubstituted pyrrolidine; tandem cyclization