title: Dengue fever and human T-cell lymphotropic virus type 1 infection.
abstract: Globalization has increased both the number of emergent diseases and the diversity of co-infections, which could in turn mutually influence the pathogenesis of well-known infectious diseases. Here, we report the first series of chronic human T-cell lymphotropic virus type 1 (HTLV-1) patients co-infected with the dengue fever virus. As both of these diseases are immuno-mediated, we anticipated interference in the development of both diseases, with atypical clinical and laboratory parameter results. All the patients had classic dengue fever, and the main outstanding abnormality was leukopenia associated with lymphopenia. Although a mutual influence was expected, dengue fever did not affect the clinical course of HTLV-1 infection, and HTLV-1 proviral loads revealed unpredictable patterns of change.
authors.affiliation: Laboratório de Pesquisa Clínica em Doenças Infecciosas, Instituto de Pesquisa Clínica Evandro Chagas - Fiocruz, Avenida Brasil 4365, Manguinhos, Rio de Janeiro CEP 21045-900, Brazil.
authors.forename: Cecília Lameirinhas
authors.initials: CL
authors.lastname: Longo
authors.forename: Patricia
authors.initials: P
authors.lastname: Brasil
authors.forename: Otávio de Melo
authors.initials: Ode M
authors.lastname: Espíndola
authors.forename: Ana Claudia Celestino Bezerra
authors.initials: AC
authors.lastname: Leite
authors.forename: Rita Maria Ribeiro
authors.initials: RM
authors.lastname: Nogueira
authors.forename: Otília
authors.initials: O
authors.lastname: Lupi
authors.forename: Elizabeth de Souza
authors.initials: Ede S
authors.lastname: Neves
mesh_terms: D060085:Coinfection; D003715:Dengue / Q000150:complications* / Q000276:immunology; D003716:Dengue Virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015490:HTLV-I Infections / Q000150:complications* / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007970:Leukopenia / Q000821:virology; D008231:Lymphopenia / Q000821:virology; D008297:Male; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D019562:Viral Load
chemical_list: D007075:Immunoglobulin M