title: Designing polysaccharide-based antibacterial biomaterials for wound healing applications.
abstract: In this study, the development and characterization of novel polymer blends based on chitosan-poly (vinyl alcohol) and physically cross-linked by freeze-thaw method for possible use in a variety of biomedical application is reported. The present investigation deals with designing savlon-loaded blend hydrogels (coined as cryogels) of poly (vinyl alcohol) (PVA) and chitosan by repeated freeze-thaw method and their characterization by SEM and FTIR techniques. The FTIR spectra clearly reveal that savlon-loaded chitosan and PVA blends are bonded together through hydrogen bonding. The SEM analysis suggests that cryogels show a well-defined porous morphology. The prepared cryogels were also investigated for swelling and deswelling behaviors. The results reveal that both the swelling and deswelling behaviors greatly depend on factors like chemical composition of the cryogels, number of freeze-thaw cycles, pH and temperature of the swelling bath. The savlon-loaded blends were also investigated for their in vitro blood compatibility and antibacterial activity.
authors.affiliation: Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, Madhya Pradesh, India.
authors.forename: Amita
authors.initials: A
authors.lastname: Chhatri
authors.forename: Jaya
authors.initials: J
authors.lastname: Bajpai
authors.forename: A K
authors.initials: AK
authors.lastname: Bajpai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D059985:Cryogels / Q000737:chemistry; D015195:Drug Design; D004926:Escherichia coli / Q000378:metabolism; D005615:Freezing; D006461:Hemolysis; D006801:Humans; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D059985:Cryogels; D011108:Polymers; D011134:Polysaccharides; D011142:Polyvinyl Alcohol; D048271:Chitosan
keywords: antibacterial activity; deswelling; freeze-thaw; hydrogel; wound dressing