title: Can vitamin D supplementation improve the severity of congestive heart failure?
abstract: The aim of the present study was to investigate whether vitamin D supplementation could improve biochemical findings and functional capacity of patients with heart failure (HF). One hundred patients with New York Heart Association (NYHA) class I through III HF were included in this prospective study and their 25-hydroxyvitamin D levels were evaluated. Only 6% of the participants had a sufficient serum concentration of 25(OH) D >30 nmol/L. Patients with insufficient or deficient serum levels of 25(OH) D (<30 ng/mL and <20 ng/mL, respectively) received oral vitamin D3 (cholecalciferol) for a total period of 4 months. Vitamin D supplementation increased mean serum concentration of 25(OH) D from 12.63±7.60 nmol/L to 54.49±18.01 nmol/L (P<.001). After vitamin D supplementation, the serum level of pro-brain natriuretic peptide markedly decreased (P<.001). Cholecalciferol significantly decreased high-sensitivity C-reactive protein level (P<.001). Restoration of serum 25(OH) D level was also associated with substantial improvement in NYHA class (P<.001) and 6-minute walk distance (P<.001).
authors.affiliation: Department of Heart Failure and Transplantation, Fellowship in Heart Failure & Transplantation, Rajaei Cardiovascular, Medical and Research Center, Tehran University of Medical Sciences, Tehran, Iran. amina33@gmail.com
authors.forename: Ahmad
authors.initials: A
authors.lastname: Amin
authors.forename: Shima
authors.initials: S
authors.lastname: Minaee
authors.forename: Mitra
authors.initials: M
authors.lastname: Chitsazan
authors.forename: Nassim
authors.initials: N
authors.lastname: Naderi
authors.forename: Sepideh
authors.initials: S
authors.lastname: Taghavi
authors.forename: Maryam
authors.initials: M
authors.lastname: Ardeshiri
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D019587:Dietary Supplements; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D014807:Vitamin D / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D014815:Vitamins; D014807:Vitamin D; D002097:C-Reactive Protein; C104450:25-hydroxyvitamin D