title: A 22-year Northern Irish experience of carotid body tumours.
abstract: OBJECTIVE
  Carotid body tumours (CBTs) are rare vascular neoplasms originating in paraganglionic cells of the carotid bifurcation. The aim of this study was to review all patients diagnosed with CBTs in Northern Ireland.
  
  
  METHODS
  A retrospective review was performed of all patients who had CBTs treated at our institutions between 1987 and 2009. Patient demographics, clinical symptomatology, investigative modality, therapeutic intervention, pathological analysis and long-term outcomes were assessed.
  
  
  RESULTS
  Twenty-nine patients were identified with 33 CBTs and three glomus intravagale tumours (GITs). Six patients had bilateral CBTs (21%), one of whom had a synchronous GIT. Twenty-six patients underwent a total of 30 operative procedures for the resection of 28 CBTs and 3 GITs. Conventional operative treatment included subadventitial tumour excision. A vascular shunt facilitated arterial reconstruction following the removal of seven (23%) tumours and on six of these occasions (19%) continuity was restored with an interposition vein graft. For access the external carotid artery was ligated during the removal of four tumours (13%). Two tumours were considered malignant. No peri-operative mortalities were recorded. Immediate complications included peri-operative stroke secondary to an occluded vein graft (n=1), requirement of tracheostomy (n=2), emergency haematoma drainage (n=2) and transient cranial nerve damage (n=8). Late complications included pseudoaneurysm of vein graft with subsequent stoke (n=1), permanent cranial nerve damage (n=9), Horner's syndrome (n=1) and an asymptomatic vein graft occlusion (n=1). One patient had tumour recurrence two years post-operatively and died due to pulmonary metastases. Two other patients died of unrelated causes. All other patients remain well with no evidence of tumour recurrence at mean followup of 1801 days (range 159-9208 days).
  
  
  CONCLUSIONS
  Our long-term experience is comparable with other reported case series where surgical intervention conferred a long-term survival advantage despite associated cranial nerve co-morbidities.
authors.affiliation: Department of Vascular and Endovascular Surgery, Royal Victoria Hospital, Northern Ireland.
authors.forename: Stephen
authors.initials: S
authors.lastname: O'Neill
authors.forename: Mark
authors.initials: M
authors.lastname: O'Donnell
authors.forename: Denis
authors.initials: D
authors.lastname: Harkin
authors.forename: Maurice
authors.initials: M
authors.lastname: Loughrey
authors.forename: Bernard
authors.initials: B
authors.lastname: Lee
authors.forename: Paul
authors.initials: P
authors.lastname: Blair
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002345:Carotid Body Tumor / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009660:Northern Ireland / Q000453:epidemiology; D011183:Postoperative Complications; D018714:Radiotherapy, Adjuvant / Q000706:statistics & numerical data; D012189:Retrospective Studies; D014656:Vascular Surgical Procedures; D055815:Young Adult
keywords: Carotid Body; Complications; Outcome; Surgery; Tumour