title: Copper-catalyzed N- and O-alkylation of amines and phenols using alkylborane reagents.
abstract: By the reaction of amines with alkylborane reagents in the presence of a catalytic amount of copper(II) acetate Cu(OAc)2 and di-tert-butyl peroxide, a cross-coupling reaction proceeded and alkylated amines were obtained in good to excellent yields. Phenols are also applicable for this reaction, and the corresponding alkyl aryl ethers were produced.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Sueki
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kuninobu
mesh_terms: D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D001880:Boranes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D010545:Peroxides; D010636:Phenols / Q000737:chemistry*
chemical_list: D000588:Amines; D001880:Boranes; D004987:Ethers; D007202:Indicators and Reagents; D010545:Peroxides; D010636:Phenols; C111570:di-tert-butyl peroxide; D003300:Copper