title: Pure autonomic failure with cold induced sweating.
abstract: Pure autonomic failure (PAF) is a progressive autonomic neurodegenerative disorder. Cold induced sweating occurred in syndromes with mutations in CRLF1 and CLCF1 genes and in a case of cervical dissection. A patient with PAF developed sweating induced by cool ambient temperatures. He had severe orthostatic hypotension, abnormal cardiovagal reflexes, and paradoxical sweating in the upper trunk at a room temperature of 18°C. Skin biopsy showed involvement of somatic epidermal unmyelinated nerve fibers. Quantitative sensory testing showed abnormal thresholds to all thermal modalities. Possible mechanisms include cold induced noradrenaline release in remaining autonomic innervation and a supersensitive sudomotor response.
authors.affiliation: Universidad de Valparaíso. School of Medicine, Valparaíso Chile. idiaquez@123.cl
authors.forename: Juan
authors.initials: J
authors.lastname: Idiaquez
authors.forename: Ricardo
authors.initials: R
authors.lastname: Fadic
authors.forename: Renato
authors.initials: R
authors.lastname: Verdugo
authors.forename: Juan F
authors.initials: JF
authors.lastname: Idiaquez
authors.forename: Valeria
authors.initials: V
authors.lastname: Iodice
authors.forename: David A
authors.initials: DA
authors.lastname: Low
authors.forename: C J
authors.initials: CJ
authors.lastname: Mathias
authors.forename: Raffaela
authors.initials: R
authors.lastname: Lombardi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lauria
mesh_terms: D000368:Aged; D003080:Cold Temperature; D006801:Humans; D008297:Male; D054970:Pure Autonomic Failure / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D013546:Sweating / Q000502:physiology*