title: Synthesis and application of a chiral ionic liquid functionalized β-cyclodextrin as a chiral selector in capillary electrophoresis.
abstract: A novel chiral ionic liquid functionalized β-cyclodextrin, 6-O-2-hydroxpropyltrimethylammonium-β-cyclodextrin tetrafluoroborate ([HPTMA-β-CD][BF4]), was synthesized and used as a chiral selector in capillary electrophoresis. [HPTMA-β-CD][BF4] not only increased the solubility in aqueous buffer in comparison with the parent compound, but also provided a stable reversal electroosmotic flow, and the enantioseparation of eight chiral drugs was examined in phosphate buffer containing [HPTMA-β-CD][BF4] as the chiral selector. The effects of the [HPTMA-β-CD][BF4] concentration and the background electrolyte pH were studied. Moreover, the chiral separation abilities of β-CD and [HPTMA-β-CD][BF4] were compared and possible mechanisms for the chiral recognition of [HPTMA-β-CD][BF4] are discussed.
authors.affiliation: Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yu
authors.forename: Lihua
authors.initials: L
authors.lastname: Zuo
authors.forename: Hongjiao
authors.initials: H
authors.lastname: Liu
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhang
authors.forename: Xingjie
authors.initials: X
authors.lastname: Guo
mesh_terms: D019075:Electrophoresis, Capillary / Q000295:instrumentation* / Q000379:methods; D052578:Ionic Liquids / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000302:isolation & purification; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D052578:Ionic Liquids; D004364:Pharmaceutical Preparations; D047392:beta-Cyclodextrins
keywords: 6-O-2-hydroxpropyltrimethylammonium-β-cyclodextrin tetrafluoroborate; capillary electrophoresis; chiral ionic liquid; enantioseparation