title: The involvement of a polyphenol-rich extract of black chokeberry in oxidative stress on experimental arterial hypertension.
abstract: The aim of this study is to characterize the content of Aronia melanocarpa Elliott (black chokeberry) extract and also to estimate the influence of polyphenolic compounds contained in chokeberries on oxidative stress, on an L-NAME-induced experimental model of arterial hypertension. The rat blood pressure values were recorded using a CODA Noninvasive Blood Pressure System. HPLC/DAD coupled with ElectroSpray Ionization-Mass Spectrometry allowed identification of five phenolic compounds in berries ethanolic extract as follows: chlorogenic acid, kuromanin, rutin, hyperoside, and quercetin. The serous activity of glutathione-peroxidase (GSH-Px) has significantly lower values in the hypertensive (AHT) group as compared to the group protected by polyphenols (AHT + P). The total antioxidant capacity (TAC) values are lower in the AHT group and they are significantly higher in the AHT + P group. All the measured blood pressure components revealed a biostatistically significant blood pressure drop between the AHT group and the AHT + P group. The results reveal the normalization of the reduced glutathion (GSH) concentration as well as a considerable reduction in the malondialdehyde (MDA) serum concentration in the AHT + P group. Ethanolic extract of black chokeberry fruits not only has a potential value as a prophylactic agent but also may function as a nutritional supplement in the management of arterial hypertension.
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa," 700115 Iasi, Romania.
authors.forename: Manuela
authors.initials: M
authors.lastname: Ciocoiu
authors.forename: Laurentiu
authors.initials: L
authors.lastname: Badescu
authors.forename: Anca
authors.initials: A
authors.lastname: Miron
authors.forename: Magda
authors.initials: M
authors.lastname: Badescu