title: Thyroid involvement by laryngeal cancer among Iranian patients.
abstract: OBJECTIVE
  Asian patients with laryngeal cancer have been reported to have a high prevalence of thyroid involvement. This study aimed to investigate the prevalence of thyroid invasion in Iranian patients with laryngeal cancer.
  
  
  METHODS
  Hospital records for all patients with a definite diagnosis of laryngeal cancer between 1996 and 2009 (351 patients) were reviewed, and the prevalence of thyroid invasion was established based on the pathology report at the time of surgery.
  
  
  RESULTS
  Thyroid invasion was found in 16 patients (4.55 percent), and was limited to one thyroid lobe in two-thirds of cases. All instances of thyroid invasion occurred in patients with stage III (81.25 percent) or IV (18.75 percent) cancer. No case of metastasis was reported. The glottic region was identified as the tumour origin in most cases of thyroid invasion (56.25 percent).
  
  
  CONCLUSIONS
  Most cases of thyroid invasion by laryngeal cancer occurred in cancer stage III, at grades G1 and G2, among male patients, and arose from tumours of the glottic region.
authors.affiliation: Department of Otolaryngology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: B
authors.initials: B
authors.lastname: Naghibzadeh
authors.forename: E
authors.initials: E
authors.lastname: Razmpa
authors.forename: N
authors.initials: N
authors.lastname: Amiri
authors.forename: Gh
authors.initials: G
authors.lastname: Naghibzadeh
authors.forename: F
authors.initials: F
authors.lastname: Bandarian
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007492:Iran; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D015995:Prevalence; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000473:pathology*