title: 3.0-T whole-heart coronary magnetic resonance angiography: comparison of gadobenate dimeglumine and gadofosveset trisodium.
abstract: Gadolinium enhanced coronary magnetic resonance angiography (MRA) at 3 T appears to be superior to non-contrast methods. Gadofosveset is an intravascular contrast agent that may be well suited to this application. The purpose of this study was to perform an intra-individual comparison of gadofosveset and gadobenate for coronary MRA at 3 T. In this prospective randomized study, 22 study subjects [8 (36%) male; 27.9 ± 6 years; BMI = 22.8 ± 2 kg/m(2)] underwent two studies using a contrast-enhanced inversion recovery three-dimensional fast low angle shot MRA at 3 T. The order of contrast agent administration was varied randomly, separated by an average of 30 ± 5 days, using either gadobenate dimeglumine (Gd-BOPTA; Bracco, 0.1 mmol/Kg) or gadofosveset trisodium (MS-325; Lantheus Med, 0.03 mmol/Kg). Acquisition time, signal-to-noise ratio (SNR) of coronary vessels and contrast-to-noise ratio (CNR) were evaluated. Of 308 coronary arteries and veins segment analyzed, overall SNR of coronary arteries and veins segments were not different for the two contrast agents (132 ± 79 for gadofosveset vs. 135 ± 78 for gadobenate, p = 0.69). Coronary artery CNR was greater for gadofosveset in comparison to gadobenate (73.5 ± 46.9 vs. 59.3 ± 75.7 respectively, p = 0.03). Gadofosveset-enhanced MRA images displayed better image quality than gadobenate-enhanced MRA images (2.77 ± 0.61 for gadofosveset vs. 2.11 ± 0.51, p < .001). Inter- and intra-reader variability was excellent (ICC > 0.90) for both contrast agents. Gadofosveset trisodium appears to show slightly better performance for coronary MRA at 3 T compared to gadobenate.
authors.affiliation: Radiology and Imaging Sciences, National Institutes of Health of Clinical Center, 10 Center Drive, Building 10, Rm 1C355, Bethesda, MD 20892-1182, USA.
authors.forename: Fabio S
authors.initials: FS
authors.lastname: Raman
authors.forename: Marcelo S
authors.initials: MS
authors.lastname: Nacif
authors.forename: George
authors.initials: G
authors.lastname: Cater
authors.forename: Neville
authors.initials: N
authors.lastname: Gai
authors.forename: Jacquin
authors.initials: J
authors.lastname: Jones
authors.forename: Debiao
authors.initials: D
authors.lastname: Li
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Sibley
authors.forename: Songtao
authors.initials: S
authors.lastname: Liu
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
mesh_terms: D000328:Adult; D003287:Contrast Media; D003331:Coronary Vessels / Q000033:anatomy & histology*; D005260:Female; D005682:Gadolinium; D064368:Healthy Volunteers; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008396:Maryland; D008536:Meglumine / Q000031:analogs & derivatives*; D015588:Observer Variation; D009942:Organometallic Compounds; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D059629:Signal-To-Noise Ratio; D055815:Young Adult
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D005682:Gadolinium; C109932:gadofosveset trisodium