title: Characterization of N-trimethyl chitosan/alginate complexes and curcumin release.
abstract: N-trimethyl chitosan of two quaternization degrees, DQ=20 and 80mol% and labeled as TMC20 and TMC80, were synthesized and characterized by (1)H NMR. Polyelectrolyte complexes (PECs) of TMC/alginate (TMC/ALG) were prepared at pHs 2, 7 and 10 by mixing the aqueous solutions of unlike polymers. The PECs were characterized through infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG) and wide-angle X-ray scattering (WAXS). Using the TMC of DQ=20 mol% and following the same methodology for preparing the PECs, beads of TMC20/ALG were obtained at pH 2 and loaded with curcumin (CUR) at pH 6.0-6.5. The morphology of the beads was evaluated by scanning electron microscopy (SEM). Studies in vitro of the controlled release of CUR from beads were investigated in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) and treated using conventional and partition-diffusion models. Results indicated that the beads based on TMC20 and ALG presented potential as drug-carrier to improve the solubility and biological activity of CUR at pH close to physiological one.
authors.affiliation: Grupo de Materiais Poliméricos e Compósitos, GMPC - Departamento de Química, Universidade Estadual de Maringá - UEM, Av. Colombo 5790 - CEP 87020-900, Maringá, Paraná, Brazil. afmartins50@yahoo.com.br
authors.forename: Alessandro F
authors.initials: AF
authors.lastname: Martins
authors.forename: Pedro V A
authors.initials: PV
authors.lastname: Bueno
authors.forename: Elizângela A M S
authors.initials: EA
authors.lastname: Almeida
authors.forename: Francisco H A
authors.initials: FH
authors.lastname: Rodrigues
authors.forename: Adley F
authors.initials: AF
authors.lastname: Rubira
authors.forename: Edvani C
authors.initials: EC
authors.lastname: Muniz
mesh_terms: D000464:Alginates / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D003474:Curcumin / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D020723:Glucuronic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006603:Hexuronic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; C118071:N-trimethyl chitosan chloride; D020723:Glucuronic Acid; D048271:Chitosan; D003474:Curcumin