title: Resurrecting the protein fold for disease intervention.
abstract: Because proteostasis networks manage the cellular proteome, their pharmacological manipulation might correct pathologies associated with numerous protein misfolding diseases. In this issue of Chemistry & Biology, Tong Ong and colleagues identify a novel biosynthetic juncture for glucocerebrosidase as a site for therapeutic intervention in Gaucher's disease.
authors.affiliation: Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. rsifers@bcm.edu
authors.forename: Richard N
authors.initials: RN
authors.lastname: Sifers