title: Association of an oral formulation of angiotensin-(1-7) with atenolol improves lipid metabolism in hypertensive rats.
abstract: The β-adrenergic blockers and antagonists of the renin-angiotensin system (RAS) are among the drugs that present better results in the control of cardio-metabolic diseases. The aim of the present study was to evaluate the effect of the association of the β-blocker, atenolol, and an oral formulation of Ang-(1-7) on lipid metabolism in spontaneously hypertensive rats (SHR). The main results showed that SHR treated with oral formulation of Ang-(1-7) in combination to atenolol have an improvement of lipid metabolism with a reduction of total plasma cholesterol, improvement of oral fat load tolerance and an increase in the lipolytic response stimulated by the β-adrenergic agonist, isoproterenol, without modification of resting glucose or insulin sensitivity in adipocytes. In conclusion, we showed that administration of an Ang-(1-7) oral formulation in association with a β-blocker induces beneficial effects on dyslipidemia treatment associated with hypertension.
authors.affiliation: National Institute of Science and Technology (INCT-NanoBiofar), Department of Physiology and Biophysics, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Cynthia F F
authors.initials: CF
authors.lastname: Santos
authors.forename: Sérgio H S
authors.initials: SH
authors.lastname: Santos
authors.forename: Adaliene V M
authors.initials: AV
authors.lastname: Ferreira
authors.forename: Leida M
authors.initials: LM
authors.lastname: Botion
authors.forename: Robson A S
authors.initials: RA
authors.lastname: Santos
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Campagnole-Santos
mesh_terms: D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000803:Angiotensin I / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D001262:Atenolol / Q000008:administration & dosage* / Q000494:pharmacology*; D006973:Hypertension / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D000319:Adrenergic beta-Antagonists; D010446:Peptide Fragments; D001262:Atenolol; D000803:Angiotensin I; C118790:angiotensin I (1-7)