title: Direct asymmetric aldol addition-isomerization of α,β-unsaturated γ-butyrolactam with aryl α-ketoesters: synthesis of MBH-type products.
abstract: A highly efficient direct asymmetric aldol addition-isomerization reaction at the α-position of α,β-unsaturated γ-butyrolactam and aryl α-ketoesters by using a bifunctional thiourea catalyst was achieved. Morita-Baylis-Hillman type adducts containing a quaternary stereocenter can be obtained in high yields and with excellent enantioselectivities (up to 99% ee).
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Zhang
authors.forename: Xihong
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Ma
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D007536:Isomerism; D007769:Lactams / Q000737:chemistry*; D013890:Thiourea / Q000737:chemistry
chemical_list: D000447:Aldehydes; D004952:Esters; D007769:Lactams; C116609:3-hydroxybutanal; D013890:Thiourea