title: Impact of HPV infection on the development of head and neck cancer.
abstract: Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is considered to be a distinct clinical entity with better prognosis than the classical tobacco- and alcohol-associated tumors. The increasing incidence of this neoplasia during the last decades highlights the need to better understand the role of HPV in the development of these cancers. Although the proportion of HNSCC attributed to HPV varies considerably according to anatomical site, overall approximately 25% of all HNSCC are HPV-DNA positive, and HPV-16 is by far the most prevalent type. In this review we discuss the existing evidence for a causal association between HPV infection and HNSCC at diverse anatomical head and neck subsites.
authors.affiliation: Laboratório de Biologia Molecular, Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo,São Paulo, SP, Brasil.
authors.forename: J
authors.initials: J
authors.lastname: Betiol
authors.forename: L L
authors.initials: LL
authors.lastname: Villa
authors.forename: L
authors.initials: L
authors.lastname: Sichero
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000821:virology*; D006258:Head and Neck Neoplasms / Q000821:virology*; D006801:Humans; D030361:Papillomavirus Infections; D011379:Prognosis; D012307:Risk Factors; D000077195:Squamous Cell Carcinoma of Head and Neck