title: Association of the polymorphism of APE1 gene with the risk of prostate cancer in Chinese Han population.
abstract: BACKGROUND
  DNA damage, caused by numerous carcinogens, contributes to the increased risk of different types of cancer. The base excision repair (BER) pathway including the apurinic/apyrimidic endonuclease (APE1, also known as APEX1) gene plays an important role in preventing the accumulation of DNA damage and maintaining genomic stability. The aim of the present study is to determine whether polymorphisms of APE1 are associated with the risk of prostate cancer (PCa) in the Chinese Han population.
  
  
  METHODS
  This study consisted of 198 patients with PCa and 156 healthy controls. The polymorphisms of APE1, Asp148Glu (rs1130409) and -141T/G (rs1760944) were determined by the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  The genotypic distributions of the two polymorphisms in controls were in Hardy-Weinberg equilibrium (p = 0.92 and p = 0.83, respectively). Logistic regression analysis indicated that the -141GG genotype was significantly associated with a decreased risk of PCa compared with the -141TT genotype (p = 0.03; OR 0.49; 95% CI 0.26 - 0.92). The G allele was also significantly associated with a reduced risk of PCa compared with the T allele (p = 0.02; OR 0.71; 95% CI 0.52 - 0.96). However, no association between Asp148Glu polymorphism and the risk of PCa was found.
  
  
  CONCLUSIONS
  The -141GG genotype and G allele of the APE1 gene are associated with a decreased risk of PCa in the Chinese Han population.
authors.affiliation: Department of Urology, The Second Hospital, Tianjin Medical University, Tianjin Institute of Urology, Tianjin, PR China.
authors.forename: Bao
authors.initials: B
authors.lastname: Jing
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Chang
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Yuan-Jie
authors.initials: YJ
authors.lastname: Niu
mesh_terms: D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D017931:DNA Primers; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics*; D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011471:Prostatic Neoplasms / Q000235:genetics*
chemical_list: D017931:DNA Primers; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase