title: The in vivo efficacy of Fluorinex topical fluoridation treatment.
abstract: OBJECTIVE
  This randomized, single-controlled study was performed to validate in vivo the efficacy of single Fluorinex treatment by examining fluoride incorporation into enamel using electron microscopy.
  
  
  METHODS
  Twenty healthy participants referred for routine dental treatment which also required extractions of at least two teeth as part of their treatment plan were included in this study. For each participant, one randomly selected tooth was extracted and sent for blind electron microscopic fluoride assay (control, C). Next, following a single Fluorinex treatment, the second (test, T) tooth was extracted and sent for the same assay. Intra-individual and intergroup fluoride content comparisons were performed, between control and test teeth.
  
  
  RESULTS
  Highly significant intra-individual and intergroup differences were found between the treated and untreated teeth. Fluoride atomic percent (at%) and weight percent (wt%) estimated least squares means of untreated group were found to be 0.56 and 0.48, and in the treated group 17.35 and 14.35. This increase in fluoride at% [16.78 ± 2.3 (SE)], was also significant statistically (P < .0001); likewise, the increase in fluoride wt % [13.86 ± 1.97 (SE)] was similarly significant (P < .0001). The system was well tolerated by the participants with minimal transitional mild side effects.
  
  
  CONCLUSIONS
  In vivo fluoride application using the active Fluorinex system resulted in a significant increase of fluoride content in the enamel of adult permanent teeth compared to untreated internal controls.
authors.affiliation: Department of Periodontology, Academy Centre for Dentistry Amsterdam, The Netherlands.
authors.forename: Otman
authors.initials: O
authors.lastname: Zuabi
authors.forename: Shai
authors.initials: S
authors.lastname: Frankenthal
authors.forename: Kamal
authors.initials: K
authors.lastname: Khawaled
authors.forename: Eli E
authors.initials: EE
authors.lastname: Machtei
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D002327:Cariostatic Agents / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D053672:Electrochemotherapy / Q000295:instrumentation / Q000379:methods; D005260:Female; D005459:Fluorides / Q000032:analysis; D005460:Fluorides, Topical / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D008963:Molar / Q000737:chemistry / Q000187:drug effects; D016037:Single-Blind Method
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D000149:Acidulated Phosphate Fluoride; D005459:Fluorides