title: Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus.
abstract: From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 microg/mL respectively.
authors.affiliation: Department of Chemistry, Nairobi University, P Bag 30197-00100, Nairobi, Kenya.
authors.forename: Leonidah Omosa
authors.initials: LO
authors.lastname: Kerubo
authors.forename: Jacob Ogweno
authors.initials: JO
authors.lastname: Midiwo
authors.forename: Solomon
authors.initials: S
authors.lastname: Derese
authors.forename: Moses K
authors.initials: MK
authors.lastname: Langat
authors.forename: Hosea M
authors.initials: HM
authors.lastname: Akala
authors.forename: Norman C
authors.initials: NC
authors.lastname: Waters
authors.forename: Martin
authors.initials: M
authors.lastname: Peter
authors.forename: Matthias
authors.initials: M
authors.lastname: Heydenreich
mesh_terms: D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D012674:Senecio / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D005419:Flavonoids