title: IκB-ζ deficiency leaves epithelial cells high and dry.
abstract: The pathogenic mechanisms driving Sjögren's syndrome (SS) are unclear. In this issue of Immunity, Okuma et al. (2013) demonstrate that tissue-specific dysfunction, namely deficiency of the transcriptional regulator IκB-ζ in epithelial cells, rather than hematopoietic cell pathology, is sufficient to elicit SS-like inflammation.
authors.affiliation: Institute of Neuropathology, University of Freiburg, 79100 Freiburg, Germany.
authors.forename: Stefanie M
authors.initials: SM
authors.lastname: Brendecke
authors.forename: Marco
authors.initials: M
authors.lastname: Prinz