title: Efficient synthesis of β'-amino-α,β-unsaturated ketones.
abstract: A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner-Wadsworth-Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.
authors.affiliation: Clermont Université, ENSCCF, Institut de Chimie de Clermont-Ferrand (ICCF), BP 10448, F-63000 Clermont-Ferrand, France ; CNRS, UMR 6296, Institut de Chimie de Clermont-Ferrand (ICCF), BP 80026, F-63171 Aubière, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Abrunhosa-Thomas
authors.forename: Aurélie
authors.initials: A
authors.lastname: Plas
authors.forename: Nishanth
authors.initials: N
authors.lastname: Kandepedu
authors.forename: Pierre
authors.initials: P
authors.lastname: Chalard
authors.forename: Yves
authors.initials: Y
authors.lastname: Troin
keywords: Horner–Wadsworth–Emmons reaction; stereoselective synthesis; β’-amino-α,β-unsaturated ketones