title: Unilateral humoral rejection after reoperative single-lung transplant.
abstract: The role of antibody-mediated rejection in acute and chronic rejection after lung transplantation is poorly understood. We report the case of a prior single-lung transplant recipient undergoing an acute antibody-mediated rejection isolated to her new, contralateral single-lung transplant. A 44-year-old woman 6 years after undergoing a single-lung transplant for idiopathic pulmonary fibrosis underwent a second single-lung transplant for bronchiolitis obliterans syndrome. Despite a negative crossmatch, she subsequently exhibited severe antibody-mediated rejection to her new allograft within 6 days of transplantation. The process of allograft sensitization is dynamic, and further study is warranted to better understand this process.
authors.affiliation: Division of Cardiac Surgery, Department of Surgical Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
authors.forename: Claude A
authors.initials: CA
authors.lastname: Beaty
authors.forename: Alexander
authors.initials: A
authors.lastname: Yang
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: George
authors.forename: Peter B
authors.initials: PB
authors.lastname: Illei
authors.forename: Ashish S
authors.initials: AS
authors.lastname: Shah
mesh_terms: D000328:Adult; D000917:Antibody Formation; D001989:Bronchiolitis Obliterans / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D005260:Female; D006084:Graft Rejection / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral; D016040:Lung Transplantation / Q000379:methods*; D011658:Pulmonary Fibrosis / Q000601:surgery; D012086:Reoperation; D012307:Risk Factors; D014184:Transplantation, Homologous
chemical_list: D006680:HLA Antigens