title: [Epstein-Barr virus-associated lymphoproliferations and lymphomas].
abstract: Epstein-Barr virus (EBV) is a lymphotropic herpesvirus infecting > 95 % of the worldwide population. In case of an immunodeficiency of various causes, the virus may lead to the development of a wide spectrum of lymphoproliferations and lymphomas. This encompasses mononucleosis-like lymphoproliferations, hyperplasias of various B-cell subsets as well as aggressive non-Hodgkin lymphomas and classical Hodgkin lymphoma. These lesions occur frequently extranodal and present with a polymorphous histology with angioinvasion and necrosis. Clinical data combined with the immunohistological detection of CD30 expression in the activated infected cells and the demonstration of EBV-encoded proteins and RNA transcripts are helpful for achieving precise classification of these lesions.
authors.affiliation: Institut für Pathologie, Charité Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Deutschland. ioannis.anagnostopoulos@charite.de
authors.forename: I
authors.initials: I
authors.lastname: Anagnostopoulos
authors.forename: K
authors.initials: K
authors.lastname: Jöhrens
mesh_terms: D016175:B-Lymphocyte Subsets / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D001808:Blood Vessels / Q000473:pathology; D002472:Cell Transformation, Viral; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000473:pathology / Q000821:virology; D007244:Infectious Mononucleosis / Q000473:pathology / Q000821:virology; D017730:Ki-1 Antigen / Q000032:analysis; D008223:Lymphoma / Q000473:pathology* / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000473:pathology* / Q000821:virology; D009336:Necrosis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009894:Opportunistic Infections / Q000473:pathology; D012322:RNA Precursors / Q000032:analysis; D014764:Viral Proteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen; D012322:RNA Precursors; D014764:Viral Proteins