title: Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactions.
abstract: Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenylmethoxycarbonyl).
authors.affiliation: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, UK.
authors.forename: Natasha S
authors.initials: NS
authors.lastname: Murphy
authors.forename: Panchami
authors.initials: P
authors.lastname: Prabhakaran
authors.forename: Valeria
authors.initials: V
authors.lastname: Azzarito
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Plante
authors.forename: Michaele J
authors.initials: MJ
authors.lastname: Hardie
authors.forename: Colin A
authors.initials: CA
authors.lastname: Kilner
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Warriner
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Wilson
mesh_terms: D000478:Alkylation; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D005449:Fluorenes / Q000737:chemistry*; D015394:Molecular Structure; D017433:Protein Structure, Secondary
chemical_list: C496789:9-fluorenylmethoxycarbonyl; D001549:Benzamides; D005449:Fluorenes