title: A feasibility study of induction pemetrexed plus cisplatin followed by pleurectomy/decortication aimed at macroscopic complete resection for malignant pleural mesothelioma.
abstract: A prospective multi-institutional study has been initiated in Japan to evaluate the feasibility of induction chemotherapy using pemetrexed plus cisplatin, followed by pleurectomy/decortication aimed at macroscopic complete resection in patients with resectable malignant pleural mesothelioma. The study was initiated on September 2012, for which 24 patients will be recruited over a period of 2 years. The primary endpoint is the macroscopic complete resection rate, regardless of the surgical technique employed (i.e. pleurectomy/decortication or extrapleural pneumonectomy). The secondary endpoints are the pleurectomy/decortication rate, macroscopic complete resection rate by pleurectomy/decortication, pulmonary function at 3 months after surgery, adverse events, treatment-related mortality, response rate to chemotherapy and 3-year overall survival rate.
authors.affiliation: Clinical Research Institute, National Kyushu Cancer Center, Fukuoka, Japan. shimokawa.m@nk-cc.go.jp
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Shimokawa
authors.forename: Seiki
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Fukuoka
authors.forename: Morihito
authors.initials: M
authors.lastname: Okada
authors.forename: Kohei
authors.initials: K
authors.lastname: Yokoi
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Tanaka
authors.forename: Takeharu
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Daimon
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005240:Feasibility Studies; D005260:Female; D005971:Glutamates / Q000008:administration & dosage; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D060828:Induction Chemotherapy; D007564:Japan; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D000068437:Pemetrexed; D010994:Pleura / Q000601:surgery; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D002945:Cisplatin