title: A Conspectus of Cellular Mechanisms of Nitrosothiol Formation from Nitric Oxide.
abstract: Although chemical mechanisms for the formation of nitrosothiol from •NO have been studied extensively "in the test tube", surprisingly little is known regarding the mechanism(s) of how nitrosothiols are formedin vivo. This lack of understanding has hampered more general acceptance of the concept of cysteine nitrosothiol formation as a generally applicable, regulated, and functionally significant protein posttranslational modification (as opposed to multiple other •NO-induced thiol modifications). Here we provide a brief overview/summary of the cellular formation of nitrosothiols from •NOviatwo possible mechanisms involving oxygen or transition metals.
authors.affiliation: Center for Free Radical Biology Departments of Anesthesiology, University of Alabama Birmingham, Birmingham, AL 35294.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Jack R
authors.initials: JR
authors.lastname: Lancaster
keywords: cytochrome c; dinitrosyliron complexes; nitric oxide; nitrogen monoxide; nitrosation; nitrosothiol