title: Thyroid function and cognition in the euthyroid elderly: a case-control study embedded in Quebec longitudinal study - NuAge.
abstract: It is presently unclear whether there is a significant association between thyroid function and cognitive decline in euthyroid elderly. This case-control study aimed to examine serum thyroid stimulating hormone (TSH), total thyroxine, free thyroxine, total triiodothyronine, and free triiodothyronine in relation to cognitive decline over a 3-year period in a subsample of 62 participants (31 pairs) aged 67 years and over at baseline from the NuAge study (Quebec longitudinal study). They were matched for age, sex and global cognition. In conditional regression logistic models, there was no significant association between any thyroid function indices and the 3-year risk of cognitive decline as measured with the Modified Mini-Mental State Examination (3MS). TSH and thyroid hormones do not appear to be associated with cognitive decline in euthyroid older persons. These findings need confirmation given the small number of pairs of subjects.
authors.affiliation: Research Center on Aging, Sherbrooke, QC, Canada J1H 4C4; Department of Physiology and Biophysics, Université de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4. Electronic address: Alexandre.Castellano@USherbrooke.ca.
authors.forename: Christian-Alexandre
authors.initials: CA
authors.lastname: Castellano
authors.forename: Danielle
authors.initials: D
authors.lastname: Laurin
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Langlois
authors.forename: Mélanie
authors.initials: M
authors.lastname: Fortier
authors.forename: Daniel
authors.initials: D
authors.lastname: Tessier
authors.forename: Pierrette
authors.initials: P
authors.lastname: Gaudreau
authors.forename: Guylaine
authors.initials: G
authors.lastname: Ferland
authors.forename: Hélène
authors.initials: H
authors.lastname: Payette
authors.forename: Dominique
authors.initials: D
authors.lastname: Lorrain
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Cunnane
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011792:Quebec; D012306:Risk; D012494:Sampling Studies; D011795:Surveys and Questionnaires; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
keywords: Aging; Cognition; Euthyroidism; NuAge cohort; TSH; Thyroid hormones