title: Uncovering the mechanisms that regulate tumor-induced T-cell anergy.
abstract: Helper T cells become hyporesponsive in the tumor microenvironment (at least in part) owing to the NFAT1-dependent expression of anergy-associated genes. Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immune responses and improve the efficacy of immunotherapy.
authors.affiliation: Albert Einstein College of Medicine; Bronx, NY USA.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Abe
authors.forename: Fernando
authors.initials: F
authors.lastname: Macian
keywords: NFAT; T helper cell; anergy; immune evasion; melanoma