title: Efficacy of triclosan-based toothpastes in the prevention and treatment of plaque-induced periodontal and peri-implant diseases.
abstract: OBJECTIVE
  To evaluate the efficacy of triclosan (T)-based toothpaste formulations in the prevention and treatment of plaque-induced periodontal and peri-implant diseases.
  
  
  METHODS
  A review of the existing literature was conducted with a systematic approach in order to retrieve pertinent articles.
  
  
  CONCLUSIONS
  i) Compared with a control fluoride dentifrice, a fluoride dentifrice containing T formulations provides a more effective level of plaque control and gingival health in patients affected by gingivitis; ii) 0.3% T/2% copolymer/0.243% NaF formulation and 0.3% T/0.13% Ca glicerophosphate/1000 ppm F toothpaste in a natural Ca carbonate base seem the most effective T-based toothpaste formulations in controlling plaque and gingival inflammation in patients with gingivitis or mild/moderate periodontitis over a 6-month period; iii) 0.3% T/2% copolymer/0.243% NaF toothpaste formulation can reduce clinical attachment loss in young adolescents when compared with a 0.243% NaF toothpaste formulation, the magnitude of the difference being greater for patients with deep periodontal pockets at baseline; iv) 0.3% T/2% copolymer/0.243% NaF toothpaste formulation is either similarly or more efficacious in preventing the progression/recurrence of periodontal destruction when compared to a conventional fluoride toothpaste; v) 0.3% T/2% copolymer/0.243% NaF toothpaste formulation seems to be more effective than a fluoride toothpaste formulation in controlling the severity of mucosal inflammation, the incidence of mucosal bleeding as well as reducing probing pocket depth around dental implants.
authors.affiliation: Research Centre for the Study of Periodontal and Peri-implant Diseases University of Ferrara, Ferrara, Italy. leonardo.trombelli@unife.it
authors.forename: L
authors.initials: L
authors.lastname: Trombelli
authors.forename: R
authors.initials: R
authors.lastname: Farina
mesh_terms: D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D015921:Dental Implants; D003773:Dental Plaque / Q000150:complications* / Q000628:therapy; D004341:Drug Evaluation; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use; D005884:Gingival Hemorrhage / Q000517:prevention & control / Q000628:therapy; D005891:Gingivitis / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D010510:Periodontal Diseases / Q000517:prevention & control* / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000517:prevention & control / Q000628:therapy; D010518:Periodontitis / Q000517:prevention & control / Q000628:therapy; D011446:Prospective Studies; D012189:Retrospective Studies; D014099:Toothbrushing; D014100:Toothpastes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D014260:Triclosan / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D015921:Dental Implants; D014100:Toothpastes; D014260:Triclosan; D005459:Fluorides