title: Methyl jasmonate mediates upregulation of bacoside A production in shoot cultures of Bacopa monnieri.
abstract: Methyl jasmonate (MJ) enhances the production of a range of secondary metabolites including triterpenoid saponins in a variety of plant species. Here, it enhanced production of bacoside A, a valuable triterpenoid saponin having nootropic therapeutic activity in in vitro shoot cultures of Bacopa monnieri, the only known source of bacoside A. The highest yield was with 50 μM MJ giving 4.4 mg bacoside A/g dry wt; an 1.8-fold increase (compared to control) after 1 week.
authors.affiliation: B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad, Gujarat, India.
authors.forename: Poojadevi
authors.initials: P
authors.lastname: Sharma
authors.forename: Sheetal
authors.initials: S
authors.lastname: Yadav
authors.forename: Anshu
authors.initials: A
authors.lastname: Srivastava
authors.forename: Neeta
authors.initials: N
authors.lastname: Shrivastava
mesh_terms: D000085:Acetates / Q000378:metabolism*; D034681:Bacopa / Q000187:drug effects* / Q000378:metabolism*; D003517:Cyclopentanes / Q000378:metabolism*; D054883:Oxylipins / Q000378:metabolism*; D018520:Plant Shoots / Q000187:drug effects / Q000378:metabolism; D012503:Saponins / Q000096:biosynthesis*; D014315:Triterpenes; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000085:Acetates; D003517:Cyclopentanes; D054883:Oxylipins; D012503:Saponins; D014315:Triterpenes; C500175:bacoside A; C072239:methyl jasmonate