title: Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients.
abstract: This guideline provides an approach to the prevention of acute antineoplastic-induced nausea and vomiting (AINV) in children. It was developed by an international, inter-professional panel using AGREE and CAN-IMPLEMENT methods. Evidence-based interventions that provide optimal AINV control in children receiving antineoplastic agents of high, moderate, low, and minimal emetogenicity are recommended. Recommendations are also made regarding selection of antiemetic agents for children who are unable to receive corticosteroids for AINV control, the role of aprepitant and optimal doses of antiemetic agents. Gaps in the evidence used to support the recommendations were identified. The contribution of this guideline to AINV control in children requires prospective evaluation.
authors.affiliation: Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada. lee.dupuis@sickkids.ca
authors.forename: L Lee
authors.initials: LL
authors.lastname: Dupuis
authors.forename: Sabrina
authors.initials: S
authors.lastname: Boodhan
authors.forename: Mark
authors.initials: M
authors.lastname: Holdsworth
authors.forename: Paula D
authors.initials: PD
authors.lastname: Robinson
authors.forename: Richard
authors.initials: R
authors.lastname: Hain
authors.forename: Carol
authors.initials: C
authors.lastname: Portwine
authors.forename: Erin
authors.initials: E
authors.lastname: O'Shaughnessy
authors.forename: Lillian
authors.initials: L
authors.lastname: Sung
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D019317:Evidence-Based Medicine; D006801:Humans; D009325:Nausea / Q000209:etiology / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy*; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents