title: Plasma levels of CXCL1 (GRO-alpha) and CXCL10 (IP-10) are elevated in type 2 diabetic patients: evidence for the involvement of inflammation and angiogenesis/angiostasis in this disease state.
abstract: BACKGROUND
  Recent evidence has demonstrated that environment and genetic factors play pivotal roles in diabetes and its related complications. The significant contributory role of cytokines in pathogenesis of type 2 diabetes is also well documented. This study was aimed to examine and compare both CXCL1 (GRO-alpha) and CXCL10 (IP-10) circulating levels in type 2 diabetic patients and healthy controls.
  
  
  METHODS
  Peripheral blood samples were collected from 100 type 2 diabetic patients and 150 healthy controls. Circulating CXCL1 and CXCL10 levels were measured by ELISA.
  
  
  RESULTS
  Elevated serum levels of both CXCL1 and CXCL10 were found in type 2 diabetic patients in comparison to controls.
  
  
  CONCLUSIONS
  Elevated levels of CXCL1 and CXCL10 could possibly be used as a marker of inflammation and angiogenesis/angiostasis in type 2 diabetes.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Seyyed Mohamad Ali
authors.initials: SM
authors.lastname: Sajadi
authors.forename: Hossein
authors.initials: H
authors.lastname: Khoramdelazad
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Hassanshahi
authors.forename: Houshang
authors.initials: H
authors.lastname: Rafatpanah
authors.forename: Javad
authors.initials: J
authors.lastname: Hosseini
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mahmoodi
authors.forename: Mohammad Kazemi
authors.initials: MK
authors.lastname: Arababadi
authors.forename: Reza
authors.initials: R
authors.lastname: Derakhshan
authors.forename: Roshanak
authors.initials: R
authors.lastname: Hasheminasabzavareh
authors.forename: Seyed-Mostafa
authors.initials: SM
authors.lastname: Hosseini-Zijoud
authors.forename: Zahra
authors.initials: Z
authors.lastname: Ahmadi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D054360:Chemokine CXCL1 / Q000097:blood*; D054357:Chemokine CXCL10 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic
chemical_list: D015415:Biomarkers; C114753:CXCL10 protein, human; D054360:Chemokine CXCL1; D054357:Chemokine CXCL10