title: Myeloid-derived suppressor sells and the efficacy of CD8+T-cell immunotherapy.
abstract: Myeloid-derived suppressor cells (MDSCs) promote immune evasion, a key feature of oncogenesis. The restoration of immunosurveillance by immunomodulatory antibodies improves the survival of a subset of cancer patients. Preclinical studies suggest that the ablation of monocytic MDSCs may be a useful adjunct to available immunotherapeutic strategies against cancer.
authors.affiliation: Memorial Sloan-Kettering Cancer Center; New York, NY USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Lesokhin
authors.forename: Taha
authors.initials: T
authors.lastname: Merghoub
authors.forename: Jedd D
authors.initials: JD
authors.lastname: Wolchok
keywords: CCR2; GM-CSF; adoptive T-cell transfer; immunotherapy; myeloid derived suppressor cells