title: Jumping over the fence: RNA nuclear export revisited.
abstract: The nuclear envelope forms a cocoon that surrounds the cellular genome keeping it out of harm's way and can be utilized by the cell as a means of functionally regulating chromatin structure and gene expression. At the same time, this double-layered membrane system constitutes a formidable obstacle to the unimpeded flow of genetic information between the genome and the rest of the cell. The nuclear pore has been long considered the sole passageway between nucleus and cytoplasm. A new report challenges this view and proposes a novel mechanism by which RNA transcripts destined for localized translation in highly polarized cell types, cross both inner and outer nuclear envelope membranes and reach the cytoplasm without utilizing the nuclear pore route.
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA. caterina.strambio@umassmed.edu
authors.forename: Caterina
authors.initials: C
authors.lastname: Strambio-De-Castilla
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000235:genetics*; D002467:Cell Nucleus / Q000235:genetics* / Q000378:metabolism; D016764:Cell Polarity; D002843:Chromatin / Q000235:genetics; D003593:Cytoplasm / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D009685:Nuclear Envelope; D022022:Nuclear Pore / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D034443:RNA Transport / Q000235:genetics; D060449:Wnt Signaling Pathway
chemical_list: D002843:Chromatin; D009687:Nuclear Proteins; D012313:RNA
keywords: RNA export; Wnt signaling; neuromuscular junctions; nuclear envelope; nuclear lamina; nuclear pore complex