title: Taenia crassiceps infection does not influence the development of experimental rheumatoid arthritis.
abstract: It was previously reported by our group that infection with Taenia crassiceps reduces incidence and severity of inflammatory and autoimmune experimental diseases like type 1 diabetes and experimental autoimmune encephalomyelitis. In this research, we set out to study whether infection with T. crassiceps would affect the development of experimental rheumatoid arthritis (RA). We found that mice infected with the parasite and induced with experimental RA showed similar clinical scores as the noninfected experimental RA group; systemic cytokines were not affected while anti-CII Abs were higher in the infected group. Histological evaluation showed damage in both infected and noninfected experimental RA-induced groups and although some surface molecules such as PDL-2 and MR which are associated with immunomodulatory mechanisms were upregulated in the infected and RA-induced group as compared to the noninfected RA group, they did not exert any changes in the outcome of experimental RA. Thus, we determined that infection with T. crassiceps does not influence the outcome of experimental RA.
authors.affiliation: Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), 54090 Tlalnepantla, MEX, Mexico.
authors.forename: Aaxin M
authors.initials: AM
authors.lastname: Ortiz-Flores
authors.forename: Yadira
authors.initials: Y
authors.lastname: Ledesma-Soto
authors.forename: Elsa A
authors.initials: EA
authors.lastname: Calleja
authors.forename: Miriam
authors.initials: M
authors.lastname: Rodríguez-Sosa
authors.forename: Imelda
authors.initials: I
authors.lastname: Juárez
authors.forename: Luis I
authors.initials: LI
authors.lastname: Terrazas
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000150:complications / Q000276:immunology* / Q000469:parasitology; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology* / Q000469:parasitology; D001327:Autoimmune Diseases / Q000276:immunology; D002462:Cell Membrane / Q000378:metabolism; D004195:Disease Models, Animal; D007074:Immunoglobulin G / Q000276:immunology; D007249:Inflammation; D007371:Interferon-gamma / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D013621:Taenia; D013622:Taeniasis / Q000150:complications / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D007371:Interferon-gamma