title: Poly (dextrogyr-levogyr) lactide acid-triiodothyronine scaffold for peripheral nerve regeneration.
abstract: OBJECTIVE
  To evaluate the poly(dextrogyr-levogyr) lactide acid-triiodothyronine (PDLLA-T3) seeded with Schwann cells conduit for repairing sciatic nerve defect.
  
  
  METHODS
  The rats were divided into three groups: autologous nerve transplantation (Group A), PDLLA-T3 + Schwann cells (Group B) and PDLLA + Schwann cells (Group C).
  
  
  RESULTS
  Myelin sheath thickness was significantly greater in Group A compared with Group B and Group C. The regenerated nerves had nearly normal structure in Group A, and in Groups B and C nerve tissues filled in the anastomotic site and angiogenesis was noted. The mean number of myelinated nerve fibers and neurons in Group B was greater than in Group C.
  
  
  CONCLUSIONS
  PDLLA-T3 is superior to PDLLA alone for repairing nerve defects.
authors.affiliation: Department of Orthopaedics, Third Military Medical University, Chongqing City, China. 52solar@sina.cn
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Hao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000502:physiology; D006735:Horseradish Peroxidase / Q000493:pharmacokinetics; D019344:Lactic Acid / Q000494:pharmacology*; D046529:Microscopy, Electron, Transmission; D009186:Myelin Sheath / Q000502:physiology / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology*; D011091:Polyesters; D011108:Polymers / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D009418:S100 Proteins / Q000378:metabolism; D012583:Schwann Cells / Q000637:transplantation* / Q000648:ultrastructure; D012584:Sciatic Nerve / Q000502:physiology / Q000648:ultrastructure; D020426:Sciatic Neuropathy / Q000503:physiopathology / Q000628:therapy*; D016622:Silver Staining; D054457:Tissue Scaffolds; D014284:Triiodothyronine / Q000494:pharmacology*
chemical_list: D011091:Polyesters; D011108:Polymers; D009418:S100 Proteins; D014284:Triiodothyronine; D019344:Lactic Acid; C033616:poly(lactide); D006735:Horseradish Peroxidase