title: ENETS TNM Staging Predicts Prognosis in Small Bowel Neuroendocrine Tumours.
abstract: Introduction. Small bowel neuroendocrine tumours (NETs) are the most common type of gastrointestinal neuroendocrine tumours. The incidence and prevalence of these tumours are on the rise. The aims of this study were to determine prognostic clinicopathological features and whether the ENETS TNM staging system predicts prognosis and also. Method. Clinical data was collected retrospectively from 138 patients with histologically proven small bowel NETs managed at King's College Hospital. Histology was reviewed and small bowels tumours, were staged according to the ENETS TNM staging system. Results. Median age was 65 years (range 29-87). The 5-year survival was 79.5% and the 10-year survival was 48.5%. Resection of the primary tumour was associated with improved survival (120 versus 56 months, P < 0.05). On multivariate analysis prognostic factors were primary tumour resection and not having a carcinoid heart disease. TNM staging significantly separated survival of stage 2 and stage 3 from stage 4 NETs. Conclusion. Small bowel primary tumour resection and not having carcinoid heart disease are prognostic factors. The ENETS TNM staging and grading system appears to be of prognostic relevance to small bowel NETs.
authors.affiliation: Institute of Liver Studies, King's College Hospital, London SE5 9RS, UK ; Department of Gastroenterology, University Hospital Lewisham, London SE13 6LH, UK.
authors.forename: Rajaventhan
authors.initials: R
authors.lastname: Srirajaskanthan
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authors.lastname: Ahmed
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authors.lastname: Prachialias
authors.forename: P
authors.initials: P
authors.lastname: Srinivasan
authors.forename: N
authors.initials: N
authors.lastname: Heaton
authors.forename: N
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authors.lastname: Jervis
authors.forename: A
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authors.lastname: Quaglia
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authors.lastname: Vivian
authors.forename: J K
authors.initials: JK
authors.lastname: Ramage