title: Association of polymorphism in MicroRNA 219-1 with clearance of hepatitis B virus infection.
abstract: Polymorphisms in the primary microRNA region may be associated with natural course of hepatitis B virus (HBV) infection. This study evaluated if the mircoRNA 219-1 (miR-219-1) polymorphism can influence the susceptibility towards persistence of HBV infection and the progression to hepatocellular carcinoma (HCC) in patients with chronic HBV infection. A total of 1,439 individuals having either past or present evidence of HBV infection were enrolled for the study. The subjects were divided into four groups; (1) spontaneous recovery (n = 404), (2) chronic HBV carrier (n = 313), (3) chronic HBV carrier with cirrhosis (n = 305), and (4) hepatocellular carcinoma (n = 417). Genotyping was performed at three polymorphic variants (rs421446, rs107822, and rs213210) in the pri-miRNA region of miR-219-1. The rs421446 T allele was found to be strongly associated with HBV clearance (OR = 0.73, P = 0.0005 in a codominant model and OR = 0.67, P = 0.0009 in a dominant model, OR = 0.69, P = 0.04 in a recessive model, respectively). The rs107822 G allele was also found to be associated with HBV clearance (OR = 0.79, P = 0.008 in a codominant model and OR = 0.72, P = 0.01 in a dominant model, respectively). In haplotype analysis, ht2 (T-G-T) and ht1 (C-A-C) were found to be in significant association with the clearance of HBV. However, no significant association was observed between miR-219-1 polymorphism and the risk of HCC occurrence. This result suggests that polymorphisms in the pri-miRNA region of miR-219-1 might be a genetic factor for HBV clearance after infection.
authors.affiliation: Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Jae Youn
authors.initials: JY
authors.lastname: Cheong
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Yoon Jun
authors.initials: YJ
authors.lastname: Kim
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Cho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000276:immunology / Q000821:virology; D002353:Carrier State / Q000276:immunology / Q000821:virology; D016022:Case-Control Studies; D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000235:genetics / Q000276:immunology / Q000821:virology; D008113:Liver Neoplasms / Q000235:genetics / Q000276:immunology / Q000821:virology; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000276:immunology*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: C578248:MIRN219 microRNA, human; D035683:MicroRNAs