title: Amygdalin inhibits renal fibrosis in chronic kidney disease.
abstract: Renal interstitial fibrosis is a common outcome of chronic renal diseases. Amygdalin is one of a number of nitrilosides, the natural cyanide‑containing substances abundant in the seeds of plants of the prunasin family that are used to treat cancer and relieve pain. However, whether amygdalin inhibits the progression of renal fibrosis or not remains unknown. The present study aimed to assess the therapeutic potential of amygdalin by investigating its effect and potential mechanism on the activation of renal interstitial fibroblast cells and renal fibrosis in rat unilateral ureteral obstruction (UUO). Treatment of the cultured renal interstitial fibroblasts with amygdalin inhibited their proliferation and the production of transforming growth factor (TGF)‑β1. In the rat model of obstructive nephropathy, following ureteral obstruction, the administration of amygdalin immediately eliminated the extracellular matrix accumulation and alleviated the renal injury on the 21st day. Collectively, amygdalin attenuated kidney fibroblast (KFB) activation and rat renal interstitial fibrosis. These results indicate that amygdalin is a potent antifibrotic agent that may have therapeutic potential for patients with fibrotic kidney diseases.
authors.affiliation: Organ Transplant Institute, Fuzhou General Hospital, Dong Fang Hospital of Xiamen University and Fujian Key Laboratory of Transplant Biology, Fuzhou, Fujian 350025, PR China.
authors.forename: Junqi
authors.initials: J
authors.lastname: Guo
authors.forename: Weizheng
authors.initials: W
authors.lastname: Wu
authors.forename: Mingxiong
authors.initials: M
authors.lastname: Sheng
authors.forename: Shunliang
authors.initials: S
authors.lastname: Yang
authors.forename: Jianming
authors.initials: J
authors.lastname: Tan
mesh_terms: D000678:Amygdalin / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010641:Phenotype; D051381:Rats; D017208:Rats, Wistar; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control*; D013194:Staining and Labeling; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D014517:Ureteral Obstruction / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
chemical_list: D053773:Transforming Growth Factor beta1; D000678:Amygdalin