title: Toward mucoadhesive hydrogel formulations for the management of xerostomia: the physicochemical, biological, and pharmacological considerations.
abstract: Although hydrogel formulations that may be applied to many mucosal surfaces are now readily accessible, little research effort has been concentrated on the development of systems that may be usefully employed for the prolonged hydration of the oral cavity. To this end, and set within the context of oral care in general, this review considers the requirements for the design of hydrogel formulations with an affinity for buccal cells and details methods for evaluating the performance of these formulations as treatments for the management of xerostomia.
authors.affiliation: School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, PO1 2DT, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Tsibouklis
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Middleton
authors.forename: Nisha
authors.initials: N
authors.lastname: Patel
authors.forename: Jonathan
authors.initials: J
authors.lastname: Pratten
mesh_terms: D000268:Adhesiveness / Q000187:drug effects; D001422:Bacterial Adhesion / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry* / Q000494:pharmacology*; D009061:Mouth Mucosa / Q000187:drug effects*; D014987:Xerostomia / Q000628:therapy*
chemical_list: D020099:Coated Materials, Biocompatible; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: dental care; hyposalivation; mucoadhesive hydrogel; oral care; xerostomia