title: [Effect of anticonvulsants on the nitric oxide system].
abstract: The effect of phenobarbital, carbamazepine, valproate sodium, depakine, topiramate and lamotrigine on the content of NO and NO-synthase activity in white rat brain tissues has been studied. It was established that the action of carbamazepine, valproate sodium, topiramate and lamotrigine decreases the activity of NO-synthase and the level of NO in the brain tissues. The amount of NO does not change while NO-synthase activity increases with the introduction of phenobarbital. The involvement of nitric oxide in the mechanism of action of the studied anticonvulsant drugs is discussed.
authors.forename: L A
authors.initials: LA
authors.lastname: Gromov
authors.forename: I F
authors.initials: IF
authors.lastname: Belenichev
authors.forename: L G
authors.initials: LG
authors.lastname: Gonchar-Cherdakli
authors.forename: G A
authors.initials: GA
authors.lastname: Zhernovaia
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002220:Carbamazepine / Q000494:pharmacology; D054022:Cerebrum / Q000187:drug effects* / Q000201:enzymology; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D000077213:Lamotrigine; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D000077236:Topiramate; D014227:Triazines / Q000494:pharmacology; D014635:Valproic Acid / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077236:Topiramate; D005632:Fructose; D009569:Nitric Oxide; D002220:Carbamazepine; D014635:Valproic Acid; D019001:Nitric Oxide Synthase; D000077213:Lamotrigine; D010634:Phenobarbital