title: Feasibility of using biomarkers in blood serum as markers of effect following exposure of the lungs to particulate matter air pollution.
abstract: Particulate matter (PM) air pollution has significant cardiopulmonary health effects. Serum biomarkers may elucidate the disease mechanisms involved and provide a means for biomonitoring exposed populations, thereby enabling accurate policy decisions on air quality standards to be made. For this review, research investigating association of blood serum biomarkers and exposure to PM was identified, finding 26 different biomarkers that were significantly associated with exposure. Recent evidence links different effects to different components of PM. Future research on biomarkers of effect will need to address exposure by all PM size fractions.
authors.affiliation: Cochrane Institute of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff, United Kingdom.
authors.forename: Timothy
authors.initials: T
authors.lastname: Elvidge
authors.forename: Ian P
authors.initials: IP
authors.lastname: Matthews
authors.forename: Clive
authors.initials: C
authors.lastname: Gregory
authors.forename: Bastiaan
authors.initials: B
authors.lastname: Hoogendoorn
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D005240:Feasibility Studies; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D008171:Lung Diseases / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D018384:Oxidative Stress / Q000276:immunology; D052638:Particulate Matter / Q000009:adverse effects; D044967:Serum / Q000737:chemistry
chemical_list: D000393:Air Pollutants; D015415:Biomarkers; D052638:Particulate Matter