title: Inorganic-organic hybrid nanoparticles with biocompatible calcium phosphate thin shells for fluorescence enhancement.
abstract: Polymeric micelles consisting of asymmetric triblock copolymers were successfully used for fabrication of robust hybrid nanoparticles with highly biocompatible calcium phosphate shells. The hydrophobic polystyrene core encapsulates hydrophobic fluorescent dyes such as Nile red. The anionic polyacrylic acid provides the site for the mineralization reaction of calcium phosphate. The polyethylene glycol corona stabilizes the hybrid nanoparticles. Fluorescent dyes can be used as imaging agents for determining the location of the nanoparticles and to give an observable indication of drug delivery, while the calcium phosphate shell can enhance the fluorescence of the encapsulated dye.
authors.affiliation: World Premier International (WPI), Research Center for Materials, Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Bishnu Prasad
authors.initials: BP
authors.lastname: Bastakoti
authors.forename: Yin-Chu
authors.initials: YC
authors.lastname: Hsu
authors.forename: Shih-Hsiang
authors.initials: SH
authors.lastname: Liao
authors.forename: Kevin C-W
authors.initials: KC
authors.lastname: Wu
authors.forename: Masamichi
authors.initials: M
authors.lastname: Inoue
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Yusa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakashima
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yamauchi
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002130:Calcium Phosphates / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D013343:Styrenes / Q000138:chemical synthesis* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D004337:Drug Carriers; D005456:Fluorescent Dyes; D013343:Styrenes; C585093:poly(styrene-acrylic acid-ethylene) triblock copolymer; D011092:Polyethylene Glycols; C020243:calcium phosphate