title: Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians.
abstract: BACKGROUND
  Recent genome-wide association studies and meta-analyses have identified 47 susceptibility loci for ulcerative colitis (UC) in Caucasian populations. A previous genome-wide association study of UC in a Japanese population suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. We performed a genome-wide association studies to identify UC susceptibility loci in a Korean population and further comparative study.
  
  
  METHODS
  We analyzed 581,060 autosomal single-nucleotide polymorphisms (SNPs) in 388 individuals with UC and 739 control subjects in the discovery stage. For the validation, 64 suggestive SNPs were analyzed in an additional 417 affected individuals and 732 control subjects.
  
  
  RESULTS
  Three genetic loci were validated for significant association, and all were previously reported in Caucasians including the major histocompatibility complex region (top SNP, rs9271366; P = 1.03 × 10(-18), odds ratio [OR] = 2.10), 16q24.1 (rs16940186; P = 4.39 × 10(-10), OR = 1.56), and RNF186-OTUD3-PLA2G2E at chromosome arm 1p36.13 (top SNP, rs4654903 in OTUD3; P = 7.43 × 10(-9), OR = 0.64). Although failed to reach genome-wide statistical significance, 2 additional loci previously reported in Caucasians including rs17085007 at chromosome arm 13q12 and JAK2 at chromosome arm 9p24 were significant after Bonferroni correction (P(corrected) = 0.0016 and P(corrected) = 0.0056, respectively). FOS, UBE2L3, the JAK2 gene region, and rs1297265 at chromosome arm 21q21.1 likely play a role in both Crohn's disease and UC.
  
  
  CONCLUSIONS
  Our data support the biologic significance of the overlapping loci for UC between Caucasian and Korean populations. Our data suggest that genetic associations for UC tend to overlap more extensively among different ethnic groups than those for Crohn's disease, which shows well-established dependence on ethnicity.
authors.affiliation: Department of Gastroenterology, Asan Medical Center, Seoul, South Korea.
authors.forename: Suk-Kyun
authors.initials: SK
authors.lastname: Yang
authors.forename: Myunghee
authors.initials: M
authors.lastname: Hong
authors.forename: Wanting
authors.initials: W
authors.lastname: Zhao
authors.forename: Yusun
authors.initials: Y
authors.lastname: Jung
authors.forename: Naeimeh
authors.initials: N
authors.lastname: Tayebi
authors.forename: Byong Duk
authors.initials: BD
authors.lastname: Ye
authors.forename: Kyung-Jo
authors.initials: KJ
authors.lastname: Kim
authors.forename: Sang Hyoung
authors.initials: SH
authors.lastname: Park
authors.forename: Inchul
authors.initials: I
authors.lastname: Lee
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Lyoung Hyo
authors.initials: LH
authors.lastname: Kim
authors.forename: Hyo-Jong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sung-Ae
authors.initials: SA
authors.lastname: Jung
authors.forename: Daehee
authors.initials: D
authors.lastname: Kang
authors.forename: Hee-Shang
authors.initials: HS
authors.lastname: Youn
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Kyuyoung
authors.initials: K
authors.lastname: Song
mesh_terms: D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000378:metabolism*; D016022:Case-Control Studies; D002874:Chromosome Mapping; D003093:Colitis, Ulcerative / Q000235:genetics*; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: D015415:Biomarkers