title: A chemiluminescence imaging array for the detection of cancer cells by dual-aptamer recognition and bio-bar-code nanoprobe-based rolling circle amplification.
abstract: A chemiluminescence imaging array was developed for Ramos cell detection by employing a HRP-labeled bio-bar-code AuNP probe to amplify signals and dual-aptamer recognition to improve specificity, achieving high throughput, easy operation, rapid analysis, and high sensitivity for cancer cells.
authors.affiliation: Key Laboratory of Biochemical Analysis, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P.R. China.
authors.forename: Sai
authors.initials: S
authors.lastname: Bi
authors.forename: Bin
authors.initials: B
authors.lastname: Ji
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shusheng
authors.initials: S
authors.lastname: Zhang
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D015374:Biosensing Techniques; D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008163:Luminescent Measurements; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry*; D009360:Neoplastic Cells, Circulating / Q000737:chemistry* / Q000378:metabolism; D021141:Nucleic Acid Amplification Techniques; D019809:Streptavidin / Q000737:chemistry / Q000378:metabolism; D046888:Tissue Array Analysis
chemical_list: D052157:Aptamers, Nucleotide; D006046:Gold; D019809:Streptavidin; D006735:Horseradish Peroxidase