title: Appearance of neointima according to stent type and restenotic phase: analysis by optical coherence tomography.
abstract: OBJECTIVE
  The features of neointima after bare metal stent (BMS) or drug-eluting stent (DES) implantation have not yet been fully characterised. The aim of this study was to investigate in-stent neointima characteristics according to stent type and restenotic phase.
  
  
  RESULTS
  The study included 59 consecutive patients undergoing target lesion revascularisation for in-stent restenosis (ISR) evaluated by optical coherence tomography (OCT) during the early phase (≤1 year, n=30) and late phase (>1 year, n=29) after either BMS (n=37) or DES (n=22) implantation. The OCT signal patterns of tissues at the minimal lumen area were categorised into three patterns: (1) homogeneous high-signal band, (2) heterogeneous mixed-signal band, and (3) lipid-laden intima. The predominant OCT pattern was homogeneous high-signal band in the BMS early phase (19/21 [91%]), lipid-laden intima in the BMS late phase (12/16 [76%]), and heterogeneous mixed-signal band in the DES late phase (9/13 [69%]). Heterogeneous mixed-signal band was seen more frequently in the DES early phase compared with BMS early phase (44% vs. 9%, p<0.05).
  
  
  CONCLUSIONS
  There were differences of neointima according to stent type and restenotic phase, and this may lead to a better understanding of the different mechanisms of ISR.
authors.affiliation: Fukuyama Cardiovascular Hospital, Fukuyama, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Goto
authors.forename: Hideo
authors.initials: H
authors.lastname: Takebayashi
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Kihara
authors.forename: Arata
authors.initials: A
authors.lastname: Hagikura
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Yuetsu
authors.initials: Y
authors.lastname: Kikuta
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Sato
authors.forename: Sunao
authors.initials: S
authors.lastname: Kodama
authors.forename: Masahito
authors.initials: M
authors.lastname: Taniguchi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hiramatsu
authors.forename: Seiichi
authors.initials: S
authors.lastname: Haruta
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography / Q000379:methods; D023903:Coronary Restenosis / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058426:Neointima / Q000175:diagnosis / Q000473:pathology*; D011474:Prosthesis Design; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods