title: Lack of an association between circulating adiponectin levels and risk of colorectal adenoma.
abstract: BACKGROUND
  The putative association between serum adiponectin levels and colorectal adenomas is actually under debate. The aim of this study was to investigate this association in relation to factors known to influence the levels of adiponectin such as anthropometric, metabolic, inflammatory parameters as well as lifestyle individual characteristics.
  
  
  METHODS
  40 patients with adenomas and 40 controls were enrolled. Body weight, height, waist circumference, and blood pressure were recorded. Fasting plasma glucose, lipids, C-reactive protein, and adiponectin levels were measured. Metabolic Syndrome was defined and lifestyle characteristics assessed.
  
  
  RESULTS
  No differences were found in adiponectin values between patients and controls (p = 0.101). Adiponectin levels were significantly higher in females than in males (p = 0.004). Adiponectin levels did not result in significant association with colorectal adenomas even after adjustment for metabolic and life style parameters.
  
  
  CONCLUSIONS
  This study did not confirm the hypothesis that high levels of adiponectin confer decreased risk of colorectal adenomas.
authors.affiliation: Sezione di Biochimica Clinica, Dipartimento di Scienze della Vitae della Riproduzione, Università di Verona, Italy. elisa.danese@univr.it
authors.forename: Elisa
authors.initials: E
authors.lastname: Danese
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Minicozzi
authors.forename: Martina
authors.initials: M
authors.lastname: Montagnana
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Manzoni
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
authors.forename: Gian Cesare
authors.initials: GC
authors.lastname: Guidi
mesh_terms: D000236:Adenoma / Q000097:blood*; D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000032:analysis; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis; D008875:Middle Aged
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D008055:Lipids; D002097:C-Reactive Protein