title: [Cytokine profile of mononuclear leukocytes in patients with myocardial infarction complicated by cardiac insufficiency].
abstract: Between the pro- and antiinflammatory components of the immune system there is a dynamic balance, violation of which is an important mechanism of development of many pathological states, in particular, cardiac insufficiency. The purpose of the work was a study of secretion of cytokines by mononuclears in patients under myocardial infarction, uncomplicated (1 group) and complicated (2 group) acute cardiac insufficiency, and determination of balance between pro-(TNF-alpha, IL-6, IL-8) and antiinflammatory (1L-10) factors in development of acute cardiac insufficiency in patients with myocardial infarction. The results indicate that in patients of group 1 there is initially a high level of both proinflammatory and antiinflammatory cytokines. After 10 days, we observed a decline in the IL-6 level and an increase in the TNF-alpha and IL-10 levels. In patients of group 2 we observed initially high levels of TNF-alpha and IL-6 and a reduced levels of IL-8 and 1L-10, as compared to patients of group 1. In dynamics of supervision of this group, further increase of all proinflammatory cytokines and a decline of IL-10 was registered. Balance between the pro- and antiinflammatory cytokines reflects the index of inflammatory activity, determined by formula (TNFalpha+IL-6+IL-8)/IL-10 and testifying that in patients of group 1 in the dynamics of treatment there is normalization of cytokin's balance, accompanied by decline of the index, while in patients of group 2 the index rose at 10th day.
authors.forename: T I
authors.initials: TI
authors.lastname: Havrylenko
authors.forename: O M
authors.initials: OM
authors.lastname: Parkhomenko
authors.forename: N O
authors.initials: NO
authors.lastname: Ryzhkova
authors.forename: S M
authors.initials: SM
authors.lastname: Kozhukhov
authors.forename: L V
authors.initials: LV
authors.lastname: Iakushko
mesh_terms: D016022:Case-Control Studies; D002478:Cells, Cultured; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D016753:Interleukin-10 / Q000096:biosynthesis / Q000378:metabolism*; D015850:Interleukin-6 / Q000096:biosynthesis / Q000378:metabolism*; D016209:Interleukin-8 / Q000096:biosynthesis / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D012720:Severity of Illness Index; D058408:Th1-Th2 Balance; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10