title: Regeneration of tissues of the oral complex: current clinical trends and research advances.
abstract: Regenerative therapy in oral health care is limited by both the body's natural capacity for regeneration and the materials and methods currently available. Research on various aspects of regenerative therapy, such as tissue engineering and stem cell and gene therapy, has produced promising results. Compelling advances, ranging from the discovery and characterization of stem cell populations in oral tissue to the engineering and transplantation of whole tooth structures, could result in exciting new treatment methods for clinicians in the near future. In this review, we discuss the limitations of natural healing and regeneration of various tissues of the oral complex, including teeth, periodontium and salivary glands, and summarize current treatment methods for tissue damage as well as research advances in oral tissue regeneration.
authors.affiliation: McGill University, Montreal, Quebec.
authors.forename: Thomas T
authors.initials: TT
authors.lastname: Nguyen
authors.forename: Brennan
authors.initials: B
authors.lastname: Mui
authors.forename: Mahsa
authors.initials: M
authors.lastname: Mehrabzadeh
authors.forename: Yannie
authors.initials: Y
authors.lastname: Chea
authors.forename: Zoya
authors.initials: Z
authors.lastname: Chaudhry
authors.forename: Kamran
authors.initials: K
authors.lastname: Chaudhry
authors.forename: Simon D
authors.initials: SD
authors.lastname: Tran
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology* / Q000637:transplantation; D016301:Alveolar Bone Loss / Q000601:surgery; D000818:Animals; D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use; D001861:Bone Regeneration; D003746:Dental Enamel Proteins / Q000627:therapeutic use; D003782:Dental Pulp / Q000166:cytology; D015316:Genetic Therapy; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods / Q000639:trends; D006801:Humans; D010513:Periodontal Ligament / Q000166:cytology; D010519:Periodontium / Q000502:physiology*; D012038:Regeneration; D012469:Salivary Glands / Q000166:cytology / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D003746:Dental Enamel Proteins; C109069:enamel matrix proteins