title: The role of autophagy in plasma cell ontogenesis.
abstract: We have identified in plasma cells a novel ATG5-dependent selective negative control on the secretory pathway, which restricts antibody production, sustaining energy metabolism. Revealing new immune functions, autophagy is required in vivo for antibody responses and to maintain the memory plasma cell compartment.
authors.affiliation: MRC LMCB, University College London, London, UK.
authors.forename: Niccolò
authors.initials: N
authors.lastname: Pengo
authors.forename: Simone
authors.initials: S
authors.lastname: Cenci
mesh_terms: D000818:Animals; D001343:Autophagy / Q000276:immunology*; D002454:Cell Differentiation; D002470:Cell Survival; D019610:Cytoprotection; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010950:Plasma Cells / Q000166:cytology* / Q000276:immunology*; D056811:Unfolded Protein Response
keywords: Blimp-1; XBP-1; antibody; autophagy; bone marrow; immunity; immunological memory; niche; plasma cell; unfolded protein response