title: Red-light-controlled protein-RNA crosslinking with a genetically encoded furan.
abstract: Well red: A protein-RNA crosslinker has been genetically encoded that can be controlled with red light, thus offering high penetration depths in biological materials. This should enable the discovery and mapping of transient protein-RNA interactions and enable the design of peptide- and protein-based drugs for RNA-targeted photodynamic therapy.
authors.affiliation: Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.
authors.forename: Moritz J
authors.initials: MJ
authors.lastname: Schmidt
authors.forename: Daniel
authors.initials: D
authors.lastname: Summerer
mesh_terms: D000595:Amino Acid Sequence; D005663:Furans / Q000737:chemistry*; D008969:Molecular Sequence Data; D010778:Photochemotherapy; D016601:RNA-Binding Proteins / Q000032:analysis / Q000737:chemistry* / Q000235:genetics
chemical_list: D005663:Furans; D016601:RNA-Binding Proteins; C039281:furan