title: Zanthoxoaporphines A-C: Three new larvicidal dibenzo[de,g]quinolin-7-one alkaloids from Zanthoxylum paracanthum (Rutaceae).
abstract: The bioassay-guided purification of Zanthoxylum paracanthum (Rutaceae) extracts led to the isolation of three new alkaloids, namely 1-hydroxy-10-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxoaporphine A, 2), 1-hydroxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxoaporphine B, 3) and 1,8-dihydroxy-9-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxaporphine C, 4), and a known lignan identified as sesamin (1). Isolation and purification of the constituent compounds was achieved through conventional chromatographic methods. The chemical structures of the isolated compounds were determined on the basis of UV, IR, NMR and MS data, and confirmed by comparison with those reported in the literature. The larvicidal activity of some of the isolated compounds was investigated by using third-instar Anopheles gambiae larvae.
authors.affiliation: Department of Chemistry, Maseno University, P.O. Private Bag Maseno, Kenya ; Department of Chemistry, Kenyatta University, P.O. Box 43844, Nairobi 00100, Kenya.
authors.forename: Fidelis N
authors.initials: FN
authors.lastname: Samita
authors.forename: Louis P
authors.initials: LP
authors.lastname: Sandjo
authors.forename: Isaiah O
authors.initials: IO
authors.lastname: Ndiege
authors.forename: Ahmed
authors.initials: A
authors.lastname: Hassanali
authors.forename: Wilber
authors.initials: W
authors.lastname: Lwande
keywords: Zanthoxylum paracanthum; alkaloids; larvicidal activity