title: Diagnostic and prognostic morphometric features in WHO2003 invasive endometrial stromal tumours.
abstract: OBJECTIVE
  The aim of this study was to determine the value of morphometric features in distinguishing mild and moderate atypia and predicting the recurrence of World Health Organization 2003-defined endometrial stromal sarcoma and highly malignant undifferentiated endometrial sarcoma.
  
  
  RESULTS
  Nuclear and cytological size, shape and arrangement were morphometrically evaluated in 41 cases with consensus no/mild (n = 38) or moderate (n = 3) atypia. None of the cases showed necrosis. The prognostic value of these features in predicting recurrence was also assessed. Seven features differed. The mean and standard deviation of the nuclear volume and the distance between the nuclei were the best discriminators between the no/mild and moderate atypia, with the maximum of the nuclear volume being a practically and rapidly evaluable alternative. With the use of these features, all mild and moderate atypias were correctly classified. Seven cases recurred. The distance between the nuclei and the percentage of nuclei with one neighbour (assessed with morphometric minimum spanning tree analysis) predicted recurrence.
  
  
  CONCLUSIONS
  In invasive endometrial stromal tumours, morphometric features are useful diagnostic support tools for distinguishing mild from moderate atypia and predicting recurrence.
authors.affiliation: Department of Gynaecology, Hospital of Fudan University, Shanghai, China. jingsakura@gmail.com
authors.forename: Weiwei
authors.initials: W
authors.lastname: Feng
authors.forename: Anais
authors.initials: A
authors.lastname: Malpica
authors.forename: Yu
authors.initials: Y
authors.lastname: Yinhua
authors.forename: Emiel
authors.initials: E
authors.lastname: Janssen
authors.forename: Einar
authors.initials: E
authors.lastname: Gudlaugsson
authors.forename: Xianrong
authors.initials: X
authors.lastname: Zhou
authors.forename: Jan P A
authors.initials: JP
authors.lastname: Baak
mesh_terms: D000328:Adult; D002467:Cell Nucleus / Q000473:pathology*; D053145:Cell Nucleus Size; D048430:Cell Shape; D048429:Cell Size; D002681:China / Q000453:epidemiology; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000401:mortality; D036821:Endometrial Stromal Tumors / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult