title: Long-term accidental overdose of levetiracetam in an infant.
abstract: Levetiracetam is one of the new anticonvulsant drugs that has a high therapeutic index and potential antiepileptogenic effects. Herein, we report a patient with multidrug refractory epilepsy and Ohtahara syndrome who was accidentally administered 300 mg/kg/d for 35 days by her mother. To our knowledge, there are only a few cases of accidental overdose of levetiracetam in pediatric patients reported in the literature, and this case study is the first to report such a high and long-term dose in an infant who showed no adverse effects.
authors.affiliation: Department of Pediatrics, Baskent University Faculty of Medicine, Adana, Turkey dryaseminozkale@gmail.com.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Özkale
authors.affiliation: Department of Pediatrics, Baskent University Faculty of Medicine, Adana, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Özkale
authors.affiliation: Division of Child Neurology, Baskent University Faculty of Medicine, Adana, Turkey.
authors.forename: Semra
authors.initials: S
authors.lastname: Saygi
authors.affiliation: Division of Child Neurology, Baskent University Faculty of Medicine, Adana, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Erol
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000503:physiopathology*; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D000077287:Levetiracetam; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam
keywords: anticonvulsant; antiepileptic drug; chronic overdosage; epilepsy; levetiracetam