title: Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe.
abstract: Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β-synthase activity, and is suitable for the high-throughput discovery of novel enzyme inhibitors.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
authors.forename: Megan K
authors.initials: MK
authors.lastname: Thorson
authors.forename: Tomas
authors.initials: T
authors.lastname: Majtan
authors.forename: Jan P
authors.initials: JP
authors.lastname: Kraus
authors.forename: Amy M
authors.initials: AM
authors.lastname: Barrios
mesh_terms: D003541:Cystathionine beta-Synthase / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000737:chemistry*; D057166:High-Throughput Screening Assays; D006862:Hydrogen Sulfide / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D005456:Fluorescent Dyes; D003541:Cystathionine beta-Synthase; D006862:Hydrogen Sulfide