title: The serum IL-6 profile and Treg/Th17 peripheral cell populations in patients with type 1 diabetes.
abstract: IL-6 is a pleiotropic cytokine involved in the regulation of the immune response, inflammation, and hematopoeisis. Its elevated levels are found in a range of autoimmune and chronic inflammatory diseases. IL-6 is also involved in regulation of the balance between two T cell subsets: Tregs and Th17, which have contradictory functions in the control of inflammation. The present study provides a quantitative analysis regarding the Th17/Treg cell balance in peripheral blood of children with type 1 diabetes and its association with serum IL-6 level.
authors.affiliation: Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland. akinomab@gumed.edu.pl
authors.forename: Monika
authors.initials: M
authors.lastname: Ryba-Stanisławowska
authors.forename: Maria
authors.initials: M
authors.lastname: Skrzypkowska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Myśliwska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Myśliwiec
mesh_terms: D000293:Adolescent; D002478:Cells, Cultured; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D016176:T-Lymphocyte Subsets / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology*; D058504:Th17 Cells / Q000166:cytology*
chemical_list: D015850:Interleukin-6