title: R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis.
abstract: The tumor-associated isocitrate dehydrogenase (IDH) mutants are unique in that they have lost their normal catalytic activity and gained a novel function to produce R-2-hydroxyglutarate (R-2-HG). A recent study now shows that R-2-HG can reversibly promote leukemogenesis in vitro, suggesting a therapeutic potential of targeting mutant IDH1 and IDH2.
authors.affiliation: Key Laboratory of Molecular Medicine of Ministry of Education and Institutes of Biomedical Sciences, Shanghai Medical College, College of Life Science, Fudan University, Shanghai 200032, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Ye
authors.forename: Shenghong
authors.initials: S
authors.lastname: Ma
authors.forename: Yue
authors.initials: Y
authors.lastname: Xiong
authors.forename: Kun-Liang
authors.initials: KL
authors.lastname: Guan