title: Oligonucleotidic therapeutics.
abstract: Numerous oligonucleotide-based biopharmaceuticals have been tested to suppress disease progression. These potent therapeutics include plasmids containing transgenes, antisense oligonucleotides, ribozymes, DNAzymes, decoys, aptamers and small interfering RNAs. This perspective discusses the mechanisms and clinical applications of such oligonucleotidic therapeutics. In addition, the most promising oligonucleotides, antisense oligonucleotides and small interfering RNAs, are discussed with regard to future applications.
authors.affiliation: Osaka University Graduate School of Medicine, Departments of Advanced Technology for Transplantation, Suite 565-0871, Japan +81 6 6879 3746; +81 6 6879 3749 ; isaka@att.med.osaka-u.ac.jp.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Isaka
authors.forename: Enyu
authors.initials: E
authors.lastname: Imai
authors.forename: Shiro
authors.initials: S
authors.lastname: Takahara
authors.forename: Hiromi
authors.initials: H
authors.lastname: Rakugi