title: The automated monocyte count is independently predictive of overall survival from diagnosis in chronic lymphocytic leukaemia and of survival following first-line chemotherapy.
abstract: We conducted an analysis of the effect of monocytosis at diagnosis of CLL on subsequent overall (OS) and treatment-free survival (TFS). Monocyte counts were performed using the Sysmex XE2100 analyser. A monocyte count >0.9 × 10(9)L(-1) at the time of diagnosis was associated with a shortened OS and TFS. Monocytosis at diagnosis was associated with lymphocyte count, deletions of chromosomes 17p and 11q, the extent of IgVH somatic hypermutation and Binet stage. A multivariate analysis model which excluded somatic hypermutation found only monocyte count and age to be independently predictive of OS. The automated monocyte count is predictive of OS and TFS in newly diagnosed CLL.
authors.affiliation: Department of Haematology, Queen's Centre for Oncology and Haematology, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK.
authors.forename: Ranjana
authors.initials: R
authors.lastname: Mazumdar
authors.forename: Paul
authors.initials: P
authors.lastname: Evans
authors.forename: Rachel
authors.initials: R
authors.lastname: Culpin
authors.forename: James
authors.initials: J
authors.lastname: Bailey
authors.forename: David
authors.initials: D
authors.lastname: Allsup
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D057205:Automation, Laboratory; D001772:Blood Cell Count / Q000295:instrumentation* / Q000379:methods; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy* / Q000401:mortality*; D008297:Male; D009000:Monocytes / Q000473:pathology*; D020360:Neoadjuvant Therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome