title: Does high-frequency chest wall oscillation therapy have any impact on the infective exacerbations of chronic obstructive pulmonary disease? A randomized controlled single-blind study.
abstract: OBJECTIVE
  To investigate the impact of high-frequency chest wall oscillation in chronic obstructive pulmonary disease patients with infective exacerbation.
  
  
  METHODS
  Clinical randomized controlled trial.
  
  
  METHODS
  Patients received high-frequency chest wall oscillation therapy at the Department of Pulmonology.
  
  
  METHODS
  Stage III-IV chronic obstructive pulmonary disease patients hospitalized with acute infective exacerbation who had received high-frequency chest wall oscillation therapy were studied.
  
  
  METHODS
  Patients were randomized into two groups, which were classified as I and II. All patients have been treated with bronchodilators, antibiotics, if necessary oxygen and patient education, as part of acute chronic obstructive pulmonary disease exacerbation protocol. Group II patients received additional high-frequency chest wall oscillation therapy.
  
  
  METHODS
  Body mass index (B), forced expiratory volume in the first second (O), modified Medical Research Council dyspnea scale (D) and 6-minute walking test (E) (BODE) index, forced expiratory volume in the first second, dyspnea, exercise capacity, oxygenation parameters and hospitalization of duration were recorded at baseline and at three-days and five-days follow-up.
  
  
  RESULTS
  From April 2009 to July 2011, a total of 99 patients were assessed for eligibility, 50 patients were enrolled and randomized into two groups. A total of 50 (100%) patients (25 in Group I and 25 in Group II) were followed up for five days. Application of high-frequency chest wall oscillation therapy resulted in no significant advantage in all outcomes (p > 0.05). Mean (SD) baseline BODE index value in Group I was 7.72 (1.76), in Group II was 7.72(1.89) (p = 0.55). On the fifth-day assessment, mean (SD) BODE index value in Group I was 7.24 (1.83), in group II was 6.44 (2.46) (p = 0.18).
  
  
  CONCLUSIONS
  The application of high-frequency chest wall oscillation therapy offers no additional advantages on infective exacerbations in chronic obstructive pulmonary disease.
authors.affiliation: Department of Pulmonology, Celal Bayar University, Turkey. tugbagoktalay@yahoo.com
authors.forename: Tugba
authors.initials: T
authors.lastname: Goktalay
authors.forename: Selim E
authors.initials: SE
authors.lastname: Akdemir
authors.forename: Aylin O
authors.initials: AO
authors.lastname: Alpaydin
authors.forename: Aysin S
authors.initials: AS
authors.lastname: Coskun
authors.forename: Pinar
authors.initials: P
authors.lastname: Celik
authors.forename: Arzu
authors.initials: A
authors.lastname: Yorgancioglu
mesh_terms: D015992:Body Mass Index; D035641:Chest Wall Oscillation / Q000379:methods*; D018450:Disease Progression; D004417:Dyspnea / Q000145:classification / Q000209:etiology / Q000628:therapy*; D005080:Exercise Test; D005541:Forced Expiratory Volume; D006801:Humans; D007239:Infections / Q000209:etiology / Q000628:therapy*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000628:therapy*; D014421:Turkey
keywords: Chronic obstructive pulmonary disease exacerbations; high-frequency chest wall oscillation; pulmonary rehabilitation