title: Small animal positron emission tomography imaging and in vivo studies of atherosclerosis.
abstract: Atherosclerosis is a growing health challenge globally, and despite our knowledge of the disease has increased over the last couple of decades, many unanswered questions remain. As molecular imaging can be used to visualize, characterize and measure biological processes at the molecular and cellular levels in living systems, this technology represents an opportunity to investigate some of these questions in vivo. In addition, molecular imaging may be translated into clinical use and eventually pave the way for more personalized treatment regimes in patients. Here, we review the current knowledge obtained from in vivo positron emission tomography studies of atherosclerosis performed in small animals.
authors.affiliation: Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. annemf@sund.ku.dk
authors.forename: Anne Mette Fisker
authors.initials: AM
authors.lastname: Hag
authors.forename: Rasmus Sejersten
authors.initials: RS
authors.lastname: Ripa
authors.forename: Sune Folke
authors.initials: SF
authors.lastname: Pedersen
authors.forename: Rasmus Poul
authors.initials: RP
authors.lastname: Bodholdt
authors.forename: Andreas
authors.initials: A
authors.lastname: Kjaer
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D049628:Body Size; D004195:Disease Models, Animal; D019788:Fluorodeoxyglucose F18; D006801:Humans; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011817:Rabbits; D019275:Radiopharmaceuticals; D057170:Translational Research, Biomedical
chemical_list: D015415:Biomarkers; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18