title: Central nervous system tumors in the first year of life: a clinical and pathologic experience from a single cancer center.
abstract: OBJECTIVE
  This study aims to review our experience with central nervous system (CNS) tumors occurring during the first year of life and to report differing features found in our series.
  
  
  METHODS
  This is a retrospective study of infants with CNS tumors diagnosed at our institution from 2006 to 2011.
  
  
  RESULTS
  A total of 19 cases were identified, with a median age of 232 days and predominance of male gender. Males were younger than females at the time of diagnosis (p value = 0.039). There were 13 low-grade tumors, glial tumors being the most common (11/13, p value = 0.003) and six high-grade tumors, atypical teratoid rhabdoid tumor being the most common (4/6). Low-grade tumors predominated in the supratentorial region, while high-grade tumors were seen in the infratentorial area (p value = 0.035). Males had a predilection to have more supratentorial tumors (p value = 0.058). Four patients underwent gross total resection, and eight received chemotherapy; none received radiotherapy. Two patients had spinal cord tumors; both were of pilomyxoid astrocytoma histology. Rare tumors included hemangiopericytoma (n = 1) and atypical choroid plexus tumor (n = 1), both occurring in the supratentorial area and affecting the youngest patients in this group; they were diagnosed prenatally and at 107 days, respectively. The median progression-free and overall survivals were 269 and 667 days, respectively. Among all tested parameters, only the grade of the tumor affected the outcome.
  
  
  CONCLUSIONS
  Diagnosis and management of infant's CNS tumors remain challenging. Pathologists should be aware of the diversity of histological types. Assigning appropriate tumor grade is fundamental in predicting the outcome.
authors.affiliation: Department of Pathology, King Hussein Cancer Center, Queen Rania Al Abdullah Street, P.O. Box 1269, Al-Jubeiha, Amman, 11941, Jordan, mhussaini@khcc.jo.
authors.forename: Maysa
authors.initials: M
authors.lastname: Al-Hussaini
authors.forename: Maisa
authors.initials: M
authors.lastname: Swaidan
authors.forename: Usama
authors.initials: U
authors.lastname: Al-Jumaily
authors.forename: Awni
authors.initials: A
authors.lastname: Musharbash
mesh_terms: D016543:Central Nervous System Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies