title: High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia.
abstract: Carbapenem-resistant Acinetobacter baumannii is becoming increasingly prevalent in patients with diabetes mellitus in the Middle East. We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271 isolates to carbapenems, tigecycline and colistin were determined, followed by detection of carbapenemase genes. A blaVIM gene was detected in ~95 % of isolates; blaOXA-23 and blaOXA-40 genes were also prevalent. Diabetic patients were significantly more likely to carry carbapenem-resistant isolates. Carbapenem-resistant A. baumannii is a serious problem in diabetic patients, and molecular detection of resistance mechanisms in these isolates is required.
authors.affiliation: College of Medicine, King Faisal University, Alahsa 31982, PO Box 400, Kingdom of Saudi Arabia.
authors.forename: A A
authors.initials: AA
authors.lastname: Alsultan
authors.affiliation: Department of Life Sciences, Faculty of Science and Technology, Anglia Ruskin University, East Road, Cambridge CB1 1PT, UK.
authors.forename: B A
authors.initials: BA
authors.lastname: Evans
authors.affiliation: College of Medicine, King Faisal University, Alahsa 31982, PO Box 400, Kingdom of Saudi Arabia.
authors.forename: E A
authors.initials: EA
authors.lastname: Elsayed
authors.affiliation: King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia.
authors.forename: S I
authors.initials: SI
authors.lastname: Al-Thawadi
authors.affiliation: College of Medicine, King Faisal University, Alahsa 31982, PO Box 400, Kingdom of Saudi Arabia.
authors.forename: A Y
authors.initials: AY
authors.lastname: Al-Taher
authors.affiliation: Medical Microbiology, University of Edinburgh, The Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
authors.forename: S G B
authors.initials: SGB
authors.lastname: Amyes
authors.affiliation: College of Medicine, King Faisal University, Alahsa 31982, PO Box 400, Kingdom of Saudi Arabia.
authors.forename: A M
authors.initials: AM
authors.lastname: Al-Dughaym
authors.affiliation: Taibah University, Department of Clinical Biochemistry, Universities Road, Almadinah Almunawarah, PO Box 344, Saudi Arabia.
authors.forename: A
authors.initials: A
authors.lastname: Hamouda
mesh_terms: D000151:Acinetobacter Infections / Q000150:complications* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D015780:Carbapenems / Q000494:pharmacology*; D048909:Diabetes Complications / Q000453:epidemiology* / Q000382:microbiology; D003920:Diabetes Mellitus / Q000453:epidemiology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D012529:Saudi Arabia / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase