title: Iron(II)-catalyzed benzylic fluorination.
abstract: Direct C-F functionalization of benzylic sp(3) C-H bonds is a synthetic challenge that has yet to be propitiously overcome. A mild, one-pot synthesis of monofluorinated benzylic substrates is reported with commercially available iron(II) acetylacetonate and Selectfluor in good to excellent yields and selectivity. A convenient route to β-fluorinated products of 3-aryl ketones is also highlighted, providing a synthetic equivalent to the difficult to accomplish conjugate addition of fluoride to α,β-unsaturated ketones.
authors.affiliation: Depatment of Chemistry, New Chemistry Building, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.
authors.forename: Steven
authors.initials: S
authors.lastname: Bloom
authors.forename: Cody Ross
authors.initials: CR
authors.lastname: Pitts
authors.forename: Ryan
authors.initials: R
authors.lastname: Woltornist
authors.forename: Andrew
authors.initials: A
authors.lastname: Griswold
authors.forename: Maxwell Gargiulo
authors.initials: MG
authors.lastname: Holl
authors.forename: Thomas
authors.initials: T
authors.lastname: Lectka