title: [The influence of cardiosurgical intervention type and conditions of artificial blood circulation of perioperative dynamics of cardiac biomarkers].
abstract: 125 patients after cardiac surgery operated on with the use of artificial blood circulation (ABC) were followed-up. Blood levels of cardiac protein, binding aliphatic acids and troponin 1 and 3 days after the operation were registered. The study showed that aorta clamping more then 90 minutes and hypothermic perfusion regimen influence cardiomyocites negatively. The state of "surgical trauma" and reperfusional myocardium damage was approximately the same during aortic surgery, myocardium revascularization with the use of aortic clamping and cardioplegia, and correction of the acquired heart disease, according to the dynamics of the studied proteins in blood. The minimal blood level of cardiac protein, binding aliphatic acids after coronary by-pass surgery on the working heart witnesses about negative influence of crystalloid hypothermic cardioplegia on coronary microcirculation.
authors.forename: I I
authors.initials: II
authors.lastname: Dement'eva
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Morozov
authors.forename: M A
authors.initials: MA
authors.lastname: Charnaia
mesh_terms: D015415:Biomarkers / Q000097:blood*; D006348:Cardiac Surgical Procedures; D002318:Cardiovascular Diseases / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D003326:Coronary Circulation; D005112:Extracorporeal Circulation / Q000379:methods*; D006324:Heart Arrest, Induced; D006801:Humans; D007036:Hypothermia, Induced; D009206:Myocardium / Q000378:metabolism*; D059035:Perioperative Period; D014336:Troponin / Q000097:blood*
chemical_list: D015415:Biomarkers; D014336:Troponin