title: A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2011.
abstract: Cancer continues to be a major public health problem despite the efforts that have been made in the search for novel drugs and treatments. The current sources sought for the discovery of new molecules are plants, animals and minerals. During the past decade, the search for anticancer agents of marine origin to fight chemo-resistance has increased greatly. Each year, several novel anticancer molecules are isolated from marine organisms and represent a renewed hope for cancer therapy. The study of structure-function relationships has allowed synthesis of analogues with increased efficacy and less toxicity. In this report, we aim to review 42 compounds of marine origin and their derivatives that were published in 2011 as promising anticancer compounds.
authors.affiliation: Laboratory of Molecular and Cellular Biology of Cancer (LBMCC), Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg. marcdiederich@snu.ac.kr
authors.forename: Wamtinga Richard
authors.initials: WR
authors.lastname: Sawadogo
authors.forename: Marc
authors.initials: M
authors.lastname: Schumacher
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Teiten
authors.forename: Claudia
authors.initials: C
authors.lastname: Cerella
authors.forename: Mario
authors.initials: M
authors.lastname: Dicato
authors.forename: Marc
authors.initials: M
authors.lastname: Diederich
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products