title: Prognostic importance of some clinical and therapeutic factors for the effect of portal vein embolization in patients with primarily inoperable colorectal liver metastases.
abstract: BACKGROUND
  Portal vein embolization (PVE) may increase the resectability of liver metastases. However, the problem of PVE is insufficient growth of the liver or tumor progression in some patients. The aim of this study was to evaluate the significance of commonly available clinical factors for the result of PVE.
  
  
  METHODS
  Portal vein embolization was performed in 38 patients with colorectal liver metastases. Effects of age, gender, time between PVE and liver resection, oncological therapy after PVE, indocyanine green retention rate test, synchronous, metachronous and extrahepatic metastases, liver volume before and after PVE, increase of liver volume after PVE and the quality of liver parenchyma before PVE on the result of PVE were evaluated.
  
  
  RESULTS
  Liver resection was performed in 23 (62.2%) patients within 1.3 ±0.4 months after PVE. Tumor progression occurred in 9 (23.7%) patients and 6 (15.8%) patients had insufficient liver hypertrophy. Significant clinical factors of PVE failure were number of liver metastases (cut-off - 4; odds ratio - 4.7; p < 0.03), liver volume after PVE (cut-off 1000 cm(3); odds ratio - 5.1; p < 0.02), growth of liver volume after PVE (cut-off 150 cm(3); odds ratio - 18.7; p < 0.002), oncological therapy administered concomitantly with PVE (p < 0.003).
  
  
  CONCLUSIONS
  Negative clinical factors of resectability of colorectal cancer liver metastases after PVE included more than four liver metastases, liver volume after PVE < 1000 cm(3), growth of the contralateral lobe by less than 150 cm(3) and concurrent oncological therapy.
authors.affiliation: University Hospital, School of Medicine, Pilsen, Czech Republic.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Treska
authors.forename: Tomas
authors.initials: T
authors.lastname: Skalicky
authors.forename: Alan
authors.initials: A
authors.lastname: Sutnar
authors.forename: Liska
authors.initials: L
authors.lastname: Vaclav
authors.forename: Jakub
authors.initials: J
authors.lastname: Fichtl
authors.forename: Judita
authors.initials: J
authors.lastname: Kinkorova
authors.forename: Monika
authors.initials: M
authors.lastname: Vachtova
authors.forename: Andrea
authors.initials: A
authors.lastname: Narsanska
keywords: colorectal liver metastases; portal vein embolization; prognostic factors