title: The role of FTO genotype on eating behavior in obese Sardinian children and adolescents.
abstract: OBJECTIVE
  We aimed to study the influence of the fat mass and obesity-associated (FTO) gene on eating behavior in 412 obese Sardinian children and adolescents. Genome-wide association studies (GWAS) have identified several susceptibility loci for obesity. Among these, the polymorphisms in the intron 1 of the FTO gene has been found associated to weight gain and obesity in various populations.
  
  
  METHODS
  All obese patients were genotyped for the FTO single nucleotide polimorphysm (SNP) rs9939609. In all subjects we evaluated eating behavior using the Child Eating Behaviour Questionnaire (CEBQ).
  
  
  RESULTS
  We found no differences in eating behavior according to the genotype, either in the entire cohort, or when subjects were subdivided into four different age groups.
  
  
  CONCLUSIONS
  FTO genotype is associated with body mass index but does not influence eating behavior in a selected cohort of obese children from the isolated genetic population of Sardinia.
authors.affiliation: Servizio di Endocrinologia Pediatrica, Ospedale Microcitemico, ASL Cagliari, Italy.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Ibba
authors.forename: Sabrina
authors.initials: S
authors.lastname: Pilia
authors.forename: Patrizia
authors.initials: P
authors.lastname: Zavattari
authors.forename: Alberto
authors.initials: A
authors.lastname: Loche
authors.forename: Chiara
authors.initials: C
authors.lastname: Guzzetti
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Casini
authors.forename: Luigi
authors.initials: L
authors.lastname: Minerba
authors.forename: Sandro
authors.initials: S
authors.lastname: Loche
mesh_terms: D000293:Adolescent; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D007558:Italy; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D011506:Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human