title: Spontaneous clearance and treatment of acute hepatitis C infection in HIV-positive men with 48 weeks of interferon-alpha and ribavirin.
abstract: Acute hepatitis C infection in the context of HIV is an emerging problem in men who have sex with men (MSM). We conducted a retrospective cohort study of MSM diagnosed with and treated for acute hepatitis C infection over 10 years. Genotype 1 was the commonest type representing 69% of cases; the spontaneous clearance rate was 20%. The overall sustained virological response (SVR) rate on an intention-to-treat basis was 83%; SVR and was 92% for those completing 48 weeks of treatment. The presence of detectable RNA at week 12 had a 100% negative predictive value for SVR. This is the largest single cohort treated with 48 weeks of interferon and ribavirin and the treatment SVR is one of the highest reported. We propose that a 48-week treatment regimen may be superior to shorter (24-week) regimens though we acknowledge the need for a randomized controlled trial.
authors.affiliation: Brighton and Sussex Medical School, Falmer.
authors.forename: D P
authors.initials: DP
authors.lastname: Webster
authors.forename: T
authors.initials: T
authors.lastname: Wojcikiewicz
authors.forename: M
authors.initials: M
authors.lastname: Keller
authors.forename: D
authors.initials: D
authors.lastname: Castelnovo
authors.forename: H
authors.initials: H
authors.lastname: Mistry
authors.forename: Y
authors.initials: Y
authors.lastname: Gilleece
authors.forename: J
authors.initials: J
authors.lastname: Tibble
authors.forename: M
authors.initials: M
authors.lastname: Fisher
mesh_terms: D000208:Acute Disease; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D005838:Genotype; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D018451:Homosexuality, Male; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000235:genetics; D012189:Retrospective Studies; D012254:Ribavirin / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D019562:Viral Load / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D012367:RNA, Viral; D012254:Ribavirin
keywords: HIV; MSM; acute; hepatitis C; interferon; men who have sex with men; ribavirin; treatment