title: Brain-derived neurotrophic factor blood levels in two models of transient brain ischemia in rats.
abstract: We monitored possible influence of transient focal and global brain ischemia on BDNF blood level. In both models noticeable fluctuation of BDNF concentration mainly in reperfusion was observed. During the first 90 min, BDNF in total blood and in blood cells continuously decreased in both models but plasma BDNF raised at 40 min and peaked at 90 min of reperfusion. Our data confirm the impact of transient brain ischemia on BDNF levels in the circulatory system, suggest blood cells as a possible source of BDNF and demonstrate the interdependence of blood compartments and physiological state of an affected organism.
authors.affiliation: Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovak Republic. gottlieb@saske.sk
authors.forename: Miroslav
authors.initials: M
authors.lastname: Gottlieb
authors.forename: Petra
authors.initials: P
authors.lastname: Bonova
authors.forename: Viera
authors.initials: V
authors.lastname: Danielisova
authors.forename: Miroslava
authors.initials: M
authors.lastname: Nemethova
authors.forename: Jozef
authors.initials: J
authors.lastname: Burda
authors.forename: Dasa
authors.initials: D
authors.lastname: Cizkova
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000097:blood* / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology; D008297:Male; D009474:Neurons / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion; D015427:Reperfusion Injury; D013053:Spectrophotometry / Q000379:methods; D013997:Time Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor