title: Hydroxysafflor yellow A (HSYA) from flowers of Carthamus tinctorius L. and its vasodilatation effects on pulmonary artery.
abstract: Flowers of Carthamus tinctorius L. are traditionally used in China to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of Carthamus tinctorius L. flowers, is known for its multiple biological activities. In the present study, HSYA was isolated from Carthamus tinctorius L. flowers by a macroporous resin adsorption chromatography method coupled with a Waters high-throughput auto-purification system and it's vasodilatation effects on pulmonary artery (PA) were explored by an assay of tension study on rat pulmonary artery (PA) rings. Results suggest that HSYA possesses vascular relaxation effects on rat PA by activating the KV channel in pulmonary vascular smooth muscle cells (PVSMCs).
authors.affiliation: College of Pharmacy, Harbin Medical University, Harbin 150081, Heilongjiang, China. wulijun_111@hotmail.com.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Bai
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
authors.forename: Chenghua
authors.initials: C
authors.lastname: Han
authors.forename: Chunyue
authors.initials: C
authors.lastname: Yu
authors.forename: Minggang
authors.initials: M
authors.lastname: Chen
authors.forename: Fa
authors.initials: F
authors.lastname: He
authors.forename: Dan
authors.initials: D
authors.lastname: Yi
authors.forename: Lijun
authors.initials: L
authors.lastname: Wu
mesh_terms: D000818:Animals; D031187:Carthamus tinctorius / Q000737:chemistry*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002681:China; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D035264:Flowers / Q000737:chemistry*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D011651:Pulmonary Artery / Q000187:drug effects* / Q000378:metabolism; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal; D011809:Quinones; C085278:hydroxysafflor yellow A; D002599:Chalcone