title: [Three patients with local recurrence of ER-positive breast cancer for whom anastrozole was clinically effective].
abstract: We treated three postmenopausal female patients with unresectable local recurrence from breast cancer. All pathological diagnoses of the local recurrence lesions were ER-positive breast cancer. For treatment, we administered anastrozole to these three patients. One has been stable disease for 25 months after taking anastrozole. Another has also showed stable disease for 18 months, and the last patient has been a partial response. We performed a biopsy from a recurring lesion on these three patients, and made a diagnosis of ER-positive breast cancer. This strategy of unresectable local recurrence revealed that these three patients could have had a stable condition for a long duration by taking anastrozole.
authors.affiliation: Dept. of Surgery, International University of Health and Welfare, Atami Hospital, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Inari
authors.forename: Masanori
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Kayo
authors.initials: K
authors.lastname: Uesugi
authors.forename: Naoki
authors.initials: N
authors.lastname: Goto
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Hatori
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Tanabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iwasaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001706:Biopsy; D001943:Breast Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D009570:Nitriles / Q000627:therapeutic use*; D017698:Postmenopause; D011960:Receptors, Estrogen / Q000032:analysis; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D011960:Receptors, Estrogen; D014230:Triazoles; D000077384:Anastrozole