title: Evaluation of the relationship between arterial blood pressure, aortic stiffness and serum endothelin-1 levels in patients with essential hypertension.
abstract: This study has attempted to evaluate the relationship between aortic stiffness, blood pressure (BP) and serum endothelin-1 (ET-1) levels in patients with essential HT. Totally 152 subjects, consisting of 103 patients diagnosed with HT at least 1 year previously and 49 healthy individuals, were enrolled in this study. They were subdivided, on the basis of BP measurements made at home, into three groups as the hypertensives with dysregulated BP (n = 56), the hypertensives with regulated BP (n = 47) and the normotensive controls (n = 49). Statistically significant differences were observed between the three groups with respect to aortic elasticity parameters (p < 0.01 for aortic strain, aortic distensibility and aortic stiffness). Serum ET-1 levels in the three groups were similar (p = 0.101), but a significant correlation was observed between the ET-1 values and the aortic elasticity parameters (p = 0.004). Alteration of the aortic elasticity parameters in patients with HT not only correlates with the serum ET-1 levels indicating endothelial dysfunction but also gives direct clues about status of BP regulation.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University , Samsun , Turkey.
authors.forename: Gokay
authors.initials: G
authors.lastname: Nar
authors.forename: Korhan
authors.initials: K
authors.lastname: Soylu
authors.forename: Murat
authors.initials: M
authors.lastname: Akcay
authors.forename: Okan
authors.initials: O
authors.lastname: Gulel
authors.forename: Serkan
authors.initials: S
authors.lastname: Yuksel
authors.forename: Murat
authors.initials: M
authors.lastname: Meric
authors.forename: Halit
authors.initials: H
authors.lastname: Zengin
authors.forename: Aliriza
authors.initials: A
authors.lastname: Erbay
authors.forename: Rukiye
authors.initials: R
authors.lastname: Nar
authors.forename: Sabri
authors.initials: S
authors.lastname: Demircan
authors.forename: Mahmut
authors.initials: M
authors.lastname: Sahin
mesh_terms: D000328:Adult; D001011:Aorta / Q000503:physiopathology*; D062186:Arterial Pressure / Q000502:physiology*; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000097:blood*; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D019332:Endothelin-1