title: Cyanobacteria: potential candidates for drug discovery.
abstract: Cyanobacteria are a rich source of vast array of bioactive molecules including toxins with wide pharmaceutical importance. They show varied bioactivities like antitumor, antiviral, antibacterial, antifungal, antimalarial, antimycotics, antiproliferative, cytotoxicity, immunosuppressive agents and multi-drug resistance reversers. A number of techniques are now developed and standardized for the extraction, isolation, detection and purification of cyanobacterial bioactive molecules. Some of the compounds are showing interesting results and have successfully reached to phase II and phase III of clinical trials. These compounds also serve as lead compounds for the development of synthetic analogues with improved bioactivity. Cyanobacterial bioactive molecules hold a bright and promising future in scientific research and great opportunity for drug discovery. This review mainly focuses on anticancerous, antiviral and antibacterial compounds from cyanobacteria; their clinical status; extraction and detection techniques.
authors.affiliation: Algology Section, CSIR-National Botanical Research Institute, Lucknow, 226001, Uttar Pradesh, India. rakhi.bajpayi@gmail.com
authors.forename: Rakhi Bajpai
authors.initials: RB
authors.lastname: Dixit
authors.forename: M R
authors.initials: MR
authors.lastname: Suseela
mesh_terms: D001688:Biological Products / Q000302:isolation & purification* / Q000494:pharmacology*; D000458:Cyanobacteria / Q000737:chemistry* / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D055442:Metabolome
chemical_list: D001688:Biological Products