title: Chemotherapy of vulvar cancer: a review.
abstract: Squamous cell carcinoma of the vulva is a rare disease with good prognosis if diagnosed early. The standard primary therapy is surgery. Neoadjuvant radiation or chemotherapy has been used to achieve resectability of the tumor and to decrease the radicality of the surgery. Chemotherapy with platinum compounds, paclitaxel and targeted therapy (erlotinib) has shown activity. International collaborative trials are needed to identify the best therapeutic strategy for patients with squamous cell cancer of the vulva who are not candidates for primary surgery or concomitant chemoradiation. We review the various treatment options available to patients with advanced or recurrent squamous cell cancer of the vulva.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Harper Professional Building, 4160 John R, Suite 721, Detroit, MI, USA.
authors.forename: Gunter
authors.initials: G
authors.lastname: Deppe
authors.forename: Ismail
authors.initials: I
authors.lastname: Mert
authors.forename: Jimmy
authors.initials: J
authors.lastname: Belotte
authors.forename: Ira S
authors.initials: IS
authors.lastname: Winer
mesh_terms: D000970:Antineoplastic Agents / Q000145:classification / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents