title: Thrombin-antithrombin levels are associated with survival in patients resuscitated from cardiac arrest.
abstract: BACKGROUND
  Following successful resuscitation from cardiac arrest, a prothrombotic state may contribute to end-organ dysfunction. We examined whether the level of serum thrombin-antithrombin (TAT) in patients hospitalized after cardiac arrest was associated with survival or the development of multiple organ failure (MOF).
  
  
  METHODS
  A prospective cohort study of subjects with in-hospital cardiac arrest (IHCA) or out-of-hospital cardiac arrest (OHCA) treated between 1/1/2007 and 5/30/2010 at a single tertiary care referral center. TAT levels were measured at hospital arrival and 24h after cardiac arrest. Logistic regression was used to determine associations between TAT levels and survival and development of MOF.
  
  
  RESULTS
  Data were available for 86 subjects. TAT levels decreased over time. Initial TAT levels (OR 0.03; 95%CI 0.001, 0.62) and category of illness severity (OR 0.39; 95% CI 0.21, 0.73) were associated with survival. Male gender (OR 3.86; 95% CI 1.17, 12.75) and category of illness severity (OR 1.86; 95% CI 1.09, 3.20), but not TAT levels were associated with development of MOF. Neither the 24-h TAT level, nor the change in TAT from initial to 24h was associated with survival when adjusted for category of illness severity.
  
  
  CONCLUSIONS
  Initial serum TAT levels and category of illness severity are associated with survival. TAT levels are not associated with development of MOF. Initial TAT levels may be a useful prognostic adjunct in the post arrest population.
authors.affiliation: University of Pittsburgh Department of Medicine, United States.
authors.forename: Jonathon
authors.initials: J
authors.lastname: Wertz
authors.forename: Ankur A
authors.initials: AA
authors.lastname: Doshi
authors.forename: Francis X
authors.initials: FX
authors.lastname: Guyette
authors.forename: Clifton W
authors.initials: CW
authors.lastname: Callaway
authors.forename: Jon C
authors.initials: JC
authors.lastname: Rittenberger
mesh_terms: D058833:Antithrombin Proteins / Q000032:analysis*; D005260:Female; D006323:Heart Arrest / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015996:Survival Rate; D013917:Thrombin / Q000032:analysis*
chemical_list: D058833:Antithrombin Proteins; D013917:Thrombin
keywords: Cardiac arrest; Hypothermia; Outcome; Prognostication; Resuscitation; Temperature