title: Final height in congenital adrenal hyperplasia: the dilemma of hypercortisolism versus hyperandrogenism.
abstract: OBJECTIVE
  The purpose of this study was to identify factors that might interfere with reaching the final height in patients with 21-hydroxylase deficiency (21-OHD).
  
  
  METHODS
  Thirty-one patients with classical 21-OHD who reached their FH in our Institution were evaluated in order to compare the Z score for final height (FHZ) with: (1) the target height, (2) the standard height for the population, and (3) the hydrocortisone treatment schedule.
  
  
  RESULTS
  The FHZ of -2.13 ± 1.11 had a significant negative correlation with the hydrocortisone doses used throughout the period of study. Patients who reached FH within the normal population range were those who received lower doses of hydrocortisone, as compared to those whose FH remained below -2 SDS.
  
  
  CONCLUSIONS
  We conclude that careful treatment adjustments have a major influence on growth of children with CAH, and that the dose range for hydrocortisone replacement that does not lead to side effects is relatively narrow. The better height outcome was achieved in 21-OHD patients who received lower doses of hydrocortisone.
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Giovana Vignoli
authors.initials: GV
authors.lastname: Cordeiro
authors.forename: Ivani Novato
authors.initials: IN
authors.lastname: Silva
authors.forename: Eugênio Marcos Andrade
authors.initials: EM
authors.lastname: Goulart
authors.forename: Antônio José das
authors.initials: AJ
authors.lastname: Chagas
authors.forename: Cláudio Elias
authors.initials: CE
authors.lastname: Kater
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000188:drug therapy*; D001827:Body Height / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000009:adverse effects; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012016:Reference Values; D016896:Treatment Outcome
chemical_list: D006854:Hydrocortisone