title: White cell count and platelet count associate with histological alcoholic hepatitis in jaundiced harmful drinkers.
abstract: BACKGROUND
  Patients with suspected alcoholic hepatitis and a Discriminant Function ≥32 underwent liver biopsy to confirm the diagnosis. Of these (n = 58), 43 had histological features of alcoholic hepatitis and 15 (25%) did not.We aimed to determine the laboratory features that differentiated those patients with a histological diagnosis of alcoholic hepatitis from those without, and assess potential clinical utility.
  
  
  METHODS
  Laboratory investigations at presentation for each of the histologically confirmed cases of alcoholic hepatitis (n = 43) were compared to those without (n = 15) to determine whether there were differences between the two groups. Univariate analysis was by Mann Whitney U Test and Multivariate analysis was by a stepwise approach.
  
  
  RESULTS
  White cell count (16.2 ± 10.5 v 6.9 ± 3.5 (× 109/L); p = 0.0001) and platelet count (178 ± 81 v 98.4 ± 43 (× 109/L); p = 0.0005) were higher in the patients with histological features of alcoholic hepatitis than in those without. The area under the ROC curve for AH diagnosis was estimated to be 0.83 (0.73, 0.94) and 0.81 (0.69, 0.93) for white cell count and platelet count respectively.
  
  
  CONCLUSIONS
  Clinicians cannot accurately differentiate patients with or without alcoholic hepatitis without liver biopsy. This is critically important when deciding on specific therapies such as corticosteroids or when interpreting data from future trials in which biopsy is not mandated. In situations where liver biopsy is unsuitable or unavailable the white cell and platelet counts can be used to determine the likelihood of histological alcoholic hepatitis and guide treatment.
authors.affiliation: The Liver Unit, Freeman Hospital, Newcastle upon Tyne, UK.
authors.forename: Timothy
authors.initials: T
authors.lastname: Hardy
authors.forename: Christopher
authors.initials: C
authors.lastname: Wells
authors.forename: Stuart
authors.initials: S
authors.lastname: Kendrick
authors.forename: Mark
authors.initials: M
authors.lastname: Hudson
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Day
authors.forename: Alastair D
authors.initials: AD
authors.lastname: Burt
authors.forename: Steven
authors.initials: S
authors.lastname: Masson
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Stewart
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications*; D000465:Algorithms; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D016022:Case-Control Studies; D005260:Female; D006519:Hepatitis, Alcoholic / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007565:Jaundice / Q000209:etiology; D007958:Leukocyte Count; D008099:Liver / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010976:Platelet Count; D012372:ROC Curve; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers