title: A case of syndrome of inappropriate scretion of anti-diuretic hormone associated with sodium valproate.
abstract: We report a rare case of the concurrent manifestation of central diabetes insipidus (CDI) and type 2 diabetes mellitus (DM). A 56 year-old man was diagnosed as a type 2 DM on the basis of hyperglycemia with polyuria and polydipsia at a local clinic two months ago and started an oral hypoglycemic medication, but resulted in no symptomatic improvement at all. Upon admission to the university hospital, the patient's initial fasting blood sugar level was 140 mg/dL, and he showed polydipsic and polyuric conditions more than 8 L urine/day. Despite the hyperglycemia controlled with metformin and diet, his symptoms persisted. Further investigations including water deprivation test confirmed the coexisting CDI of unknown origin, and the patient's symptoms including an intense thirst were markedly improved by desmopressin nasal spray (10 µg/day). The possibility of a common origin of CDI and type 2 DM is raised in a review of the few relevant adult cases in the literature.
authors.affiliation: Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Hong Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jung Kook
authors.initials: JK
authors.lastname: Wi
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Moon
authors.forename: Kyung Hwan
authors.initials: KH
authors.lastname: Jeong
authors.forename: Chun Gyoo
authors.initials: CG
authors.lastname: Ihm
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Tae Won
authors.initials: TW
authors.lastname: Lee
keywords: Central diabetes insipidus; Polyuria; Type 2 diabetes mellitus; Water deprivation test