title: Social isolation perturbs experience-driven synaptic glutamate receptor subunit 4 delivery in the developing rat barrel cortex.
abstract: In neonates, the stress of social isolation can alter developing neural circuits and cause mental illness. However, the molecular and cellular bases for these effects are poorly understood. Experience-driven synaptic AMPA receptor delivery is crucial for circuit organisation during development. In the rat, whisker experience drives the delivery of glutamate receptor subunit 4 (GluA4) but not glutamate receptor subunit 1 (GluA1) to layer 4-2/3 pyramidal synapses in the barrel cortex during postnatal day (P)8-10, whereas GluA1 but not GluA4 is delivered to these synapses during P12-14. We recently reported that early social isolation disrupts experience-driven GluA1 delivery to layer 4-2/3 pyramidal synapses during P12-14. Here, we report that neonatal isolation affects even earlier stages of development by preventing experience-dependent synaptic GluA4 delivery. Thus, social isolation severely affects synaptic maturation throughout early postnatal development.
authors.affiliation: Yokohama City University Graduate School of Medicine, Department of Physiology, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Misako
authors.initials: M
authors.lastname: Kunii
authors.forename: Susumu
authors.initials: S
authors.lastname: Jitsuki
authors.forename: Akane
authors.initials: A
authors.lastname: Sano
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kuroiwa
authors.forename: Takuya
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D017774:Long-Term Potentiation; D019579:Neocortex / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D021381:Protein Transport; D017966:Pyramidal Cells / Q000378:metabolism / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism*; D012934:Social Isolation; D013569:Synapses / Q000378:metabolism* / Q000502:physiology
chemical_list: D018091:Receptors, AMPA; C104724:glutamate receptor ionotropic, AMPA 4