title: [A role of WNT in kidney development and function].
abstract: WNT 4 is a secreted glycoprotein that is critical for nephrogenesis during mesenchymal to epithelial transformation. Lately there are some experimental modles witch confirm a role of Wnt 4 during regeneration process in acute renal failure. On the other hand there are some evidence that Wnt 4 plays important role in renal fibrosis during experimental renal injury in rats that provide tubuloinerstitial fibrosis. When will Wnt 4 have a protective role or when will induce fibrosis still is not known and therefore futher studies will be necessary to gain a more precise understanding.
authors.affiliation: Department of Nephrology, Arterial Hypertension, Dialysis, and Transplantation, Clinic of Internal Medicine, University Hospital Centre Zagreb, Zagreb, Croatia. inesmesar@yahoo.com
authors.forename: Ines
authors.initials: I
authors.lastname: Mesar
authors.forename: Petar
authors.initials: P
authors.lastname: Kes
authors.forename: Nikolina Basić
authors.initials: NB
authors.lastname: Jukić
mesh_terms: D058186:Acute Kidney Injury / Q000503:physiopathology; D000818:Animals; D007668:Kidney / Q000196:embryology* / Q000502:physiology*; D051381:Rats; D012038:Regeneration; D060528:Wnt4 Protein / Q000502:physiology*
chemical_list: D060528:Wnt4 Protein