title: Activity of crude cold-water extract of the culinary-medicinal oyster mushroom, Pleurotus ostreatus (Jacq.:Fr.) P.Kumm. (higher Basidiomycetes), and timolol maleate on induced ocular hypertension.
abstract: Aqueous crude cold-water extract from the fruiting body of the culinary-medicinal oyster mushroom Pleurotus ostreatus was assessed for activity against increased intra-ocular pressure (IOP) in mice. A 0.1% dexamethasone instillation was used to raise the intra-ocular pressure in the animals above the 21-mmHg threshold limit. The extract has intrinsic anti-hypertensive properties that are dose dependent. A comparison analysis indicated that 150 mg/mL of the crude extract produced 57.69% reduction in the intra-ocular pressure, while doses of 100 mg/ mL and 200 mg/mL produced 44.78% and 70.03% IOP reduction, respectively, compared with timolol maleate with 57.69%. The results were significant at 0.05 confidence limit (p < 0.05) when compared to a placebo and therefore support its use for the treatment of increased intra-ocular pressure.
authors.affiliation: Department of Botany, University of Calabar, P.M.B. 1115, Calabar, Nigeria. nedorg@yahoo.com
authors.forename: Joseph Kayefor
authors.initials: JK
authors.lastname: Ebigwai
authors.forename: Esther Aja
authors.initials: EA
authors.lastname: Edu
authors.forename: Edisua Hogan
authors.initials: EH
authors.lastname: Itam
authors.forename: Ann Jerry
authors.initials: AJ
authors.lastname: Mofunanya
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D003080:Cold Temperature; D003907:Dexamethasone / Q000633:toxicity; D005938:Glucocorticoids / Q000633:toxicity; D051379:Mice; D009798:Ocular Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D020076:Pleurotus / Q000737:chemistry*; D011897:Random Allocation; D013999:Timolol / Q000494:pharmacology*; D014867:Water / Q000737:chemistry*
chemical_list: D000319:Adrenergic beta-Antagonists; D005938:Glucocorticoids; D014867:Water; D003907:Dexamethasone; D013999:Timolol