title: Long-term follow-up of hepatic ultrasound findings in subjects with magnetic resonance imaging defined hepatic steatosis following clinical islet transplantation: a case-control study.
abstract: Hepatic steatosis is one complication patients may experience following clinical islet transplantation (CIT), yet the cause and consequences of this are poorly understood. The purpose of this case-control study was to examine the relationship between hepatic steatosis, metabolic parameters and graft function in an Albertan cohort of CIT recipients. Hepatic steatosis was detected by magnetic resonance imaging (MRI) in n = 10 cases age-matched with n=10 MRI-negative controls. Progression/regression of steatosis was determined by ultrasound (US) in cases. Hepatic steatosis first appeared 2.8 ± 2.2 (mean ± SD) years post-CIT, and lasted approximately 4.6 ± 2.0 years. In five cases steatosis resolved, with recurrence in two cases during the follow-up period (8.5 ± 3.2 years). No evidence of CIT causing deleterious effects on long-term liver function or graft outcome was observed.
authors.affiliation: Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB Canada.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Jackson
authors.forename: Diana R
authors.initials: DR
authors.lastname: Mager
authors.forename: Ravi
authors.initials: R
authors.lastname: Bhargava
authors.forename: Thomas
authors.initials: T
authors.lastname: Ackerman
authors.forename: Sharleen
authors.initials: S
authors.lastname: Imes
authors.forename: Grace
authors.initials: G
authors.lastname: Hubert
authors.forename: Angela
authors.initials: A
authors.lastname: Koh
authors.forename: A M James
authors.initials: AM
authors.lastname: Shapiro
authors.forename: Peter A
authors.initials: PA
authors.lastname: Senior
mesh_terms: D000328:Adult; D000416:Alberta / Q000453:epidemiology; D016022:Case-Control Studies; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D018450:Disease Progression; D005234:Fatty Liver / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006085:Graft Survival; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000009:adverse effects*; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012008:Recurrence; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D012307:Risk Factors; D014463:Ultrasonography; D055815:Young Adult
keywords: clinical islet transplantation; hepatic steatosis; magnetic resonance imaging; type 1 diabetes; ultrasound