title: Self-assembled block copolymer photonic crystal for selective fructose detection.
abstract: The use of one-dimensional photonic crystals fabricated from a self-assembled lamellar block copolymer as a sensitive and selective fructose sensor is investigated. The polystyrene-b-poly(2-vinyl pyridine) (PS-b-P2VP) films are functionalized with 2-(bromomethyl)phenylboronic acid. The boronic acid moiety confined within the lamellar morphology can reversibly bind to sugars such as fructose, imparting the photonic properties of the PS-b-P2VP film. The films exhibit a detection limit of 500 μM in water and 1mM in phosphate buffered saline. Exposure to a 50 mM solution of fructose invokes a highly visible color change from blue to orange. The films are also able to selectively recognize and respond to fructose in competitive studies in the presence of glucose, mannose and sucrose.
authors.affiliation: Fischell Department of Bioengineering, Room 2330 Jeong H. Kim Engineering Building, University of Maryland, College Park, MD 20742, USA.
authors.forename: Omar B
authors.initials: OB
authors.lastname: Ayyub
authors.forename: Michael B
authors.initials: MB
authors.lastname: Ibrahim
authors.forename: Robert M
authors.initials: RM
authors.lastname: Briber
authors.forename: Peter
authors.initials: P
authors.lastname: Kofinas
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D001897:Boronic Acids / Q000737:chemistry*; D003460:Crystallization; D005632:Fructose / Q000032:analysis*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D057230:Limit of Detection; D017785:Photons; D011137:Polystyrenes / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D011137:Polystyrenes; D011145:Polyvinyls; C521881:poly(styrene)-block-poly(2-vinylpyrindine) diblock copolymer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D005632:Fructose; C010686:benzeneboronic acid