title: Mechanisms of calcification in aortic valve disease: role of mechanokinetics and mechanodynamics.
abstract: The aortic valve is highly responsive to cyclical and continuous mechanical forces, at the macroscopic and cellular levels. In this report, we delineate mechanokinetics (effects of mechanical inputs on the cells) and mechanodynamics (effects of cells and pathologic processes on the mechanics) of the aortic valve, with a particular focus on how mechanical inputs synergize with the inflammatory cytokine and other biomolecular signaling to contribute to the process of aortic valve calcification.
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, 2213 Garland Ave, 9445 MRB IV, Nashville, TN, 37232-0493, USA. david.merryman@vanderbilt.edu
authors.forename: W David
authors.initials: WD
authors.lastname: Merryman
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Schoen
mesh_terms: D001021:Aortic Valve / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D000082882:Bicuspid Aortic Valve Disease; D001696:Biomechanical Phenomena; D002114:Calcinosis / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D006330:Heart Defects, Congenital / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D006349:Heart Valve Diseases / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology