title: A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components.
abstract: The metabolic syndrome (MetS) is a common disorder, where systemic insulin-resistance is associated with increased risk for type 2 diabetes (T2D) and cardiovascular disease. Identifying genetic traits influencing risk and progression of MetS is important. We and others previously reported a functional HMGA1 gene variant, rs146052672, predisposing to T2D. Here we investigated the association of rs146052672 variant with MetS and related components. In a case-control study from Italy and Turkey, increased risk of MetS was seen among carriers of the HMGA1 variant. In the larger Italian cohort, this variant positively correlated with BMI, hyperglycemia and insulin-resistance, and negatively correlated with serum HDL-cholesterol. Association between rs146052672 variant and MetS occurred independently of T2D, indicating that HMGA1 gene defects play a pathogenetic role in MetS and other insulin-resistance-related conditions. Overall, our results indicate that the rs146052672 variant represents an early predictive marker of MetS, as well as a predictive tool for therapy.
authors.affiliation: Department of Health Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.
authors.forename: Eusebio
authors.initials: E
authors.lastname: Chiefari
authors.forename: Sinan
authors.initials: S
authors.lastname: Tanyolaç
authors.forename: Stefania
authors.initials: S
authors.lastname: Iiritano
authors.forename: Angela
authors.initials: A
authors.lastname: Sciacqua
authors.forename: Carmelo
authors.initials: C
authors.lastname: Capula
authors.forename: Biagio
authors.initials: B
authors.lastname: Arcidiacono
authors.forename: Aurora
authors.initials: A
authors.lastname: Nocera
authors.forename: Katiuscia
authors.initials: K
authors.lastname: Possidente
authors.forename: Francesco
authors.initials: F
authors.lastname: Baudi
authors.forename: Valeria
authors.initials: V
authors.lastname: Ventura
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Brunetti
authors.forename: Francesco S
authors.initials: FS
authors.lastname: Brunetti
authors.forename: Raffaella
authors.initials: R
authors.lastname: Vero
authors.forename: Raffaele
authors.initials: R
authors.lastname: Maio
authors.forename: Manfredi
authors.initials: M
authors.lastname: Greco
authors.forename: Maria
authors.initials: M
authors.lastname: Pavia
authors.forename: Ugur
authors.initials: U
authors.lastname: Hodoglugil
authors.forename: Vincent
authors.initials: V
authors.lastname: Durlach
authors.forename: Clive R
authors.initials: CR
authors.lastname: Pullinger
authors.forename: Ira D
authors.initials: ID
authors.lastname: Goldfine
authors.forename: Francesco
authors.initials: F
authors.lastname: Perticone
authors.forename: Daniela
authors.initials: D
authors.lastname: Foti
authors.forename: Antonio
authors.initials: A
authors.lastname: Brunetti
mesh_terms: D016022:Case-Control Studies; D003710:Demography; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D025741:HMGA1a Protein / Q000235:genetics*; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D007558:Italy; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D014421:Turkey
chemical_list: D025741:HMGA1a Protein