title: Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer.
abstract: Colorectal Cancer (CRC) is the second leading cause of cancer-related mortality and is the fourth most common malignant neoplasm in USA. Escaping apoptosis and cell mutation are the prime hallmarks of cancer. It is apparent that balancing the network between DNA damage and DNA repair is critical in preventing carcinogenesis. One-third of cancers might be prevented by nutritious healthy diet, maintaining healthy weight and physical activity. In this review, an attempt is made to abridge the role of carcinogen in colorectal cancer establishment and prognosis, where special attention has been paid to food-borne mutagens and functional role of beneficial human gut microbiome in evading cancer. Further the significance of tailor-made prebiotics, probiotics and synbiotics in cancer management by bio-antimutagenic and desmutagenic activity has been elaborated. Probiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a healthy benefit on the host. Prebiotics are a selectively fermentable non-digestible oligosaccharide or ingredient that brings specific changes, both in the composition and/or activity of the gastrointestinal microflora, conferring health benefits. Synbiotics are a combination of probiotic bacteria and the growth promoting prebiotic ingredients that purport "synergism."
authors.affiliation: Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences and Bioengineering, Indian Institute of Technology, Chennai, India.
authors.forename: Maya
authors.initials: M
authors.lastname: Raman
authors.forename: Padma
authors.initials: P
authors.lastname: Ambalam
authors.forename: Kanthi Kiran
authors.initials: KK
authors.lastname: Kondepudi
authors.forename: Sheetal
authors.initials: S
authors.lastname: Pithva
authors.forename: Charmy
authors.initials: C
authors.lastname: Kothari
authors.forename: Arti T
authors.initials: AT
authors.lastname: Patel
authors.forename: Ravi Kiran
authors.initials: RK
authors.lastname: Purama
authors.forename: J M
authors.initials: JM
authors.lastname: Dave
authors.forename: B R M
authors.initials: BR
authors.lastname: Vyas
mesh_terms: D016587:Antimutagenic Agents / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000628:therapy*; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage; D054892:Metagenome; D056692:Prebiotics; D019936:Probiotics / Q000008:administration & dosage*; D058616:Synbiotics; D014481:United States
chemical_list: D016587:Antimutagenic Agents; D007155:Immunologic Factors; D056692:Prebiotics
keywords: antimutagens; cancer; colorectal cancer; hetercyclic amines; mutagens; polyaromatic hydrocarbons; prebiotics; probiotics; synbiotics