title: Light chain proximal tubulopathy without crystals in a case of Burkitt lymphoma presenting with acute kidney injury.
abstract: Acute kidney injury is a common manifestation of malignancies, either directly by the tumor or indirectly from anticancer therapy. The pathologic correlates of acute kidney injury in malignancies are many and can be diagnosed conclusively using kidney biopsy. We report a rare case of a patient with light chain proximal tubulopathy without crystals who presented with acute kidney injury. Kidney biopsy showed proximal tubulopathy without crystals with λ light chain restriction. Detailed investigations lead to a diagnosis of Burkitt lymphoma with surface λ light chain restriction.
authors.affiliation: Department of Histopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Swapnil
authors.initials: S
authors.lastname: Rane
authors.forename: Seema
authors.initials: S
authors.lastname: Rana
authors.forename: Manupdesh
authors.initials: M
authors.lastname: Sachdeva
authors.forename: Kusum
authors.initials: K
authors.lastname: Joshi
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D000328:Adult; D002051:Burkitt Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D003460:Crystallization; D003937:Diagnosis, Differential; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000737:chemistry; D007687:Kidney Tubules, Proximal / Q000276:immunology / Q000473:pathology*; D008297:Male
chemical_list: D007146:Immunoglobulin lambda-Chains
keywords: Acute kidney injury; Burkitt leukemia; kidney biopsy; light chain proximal tubulopathy; light chain proximal tubulopathy without crystals