title: Immunohistochemical analysis of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) expressions in the testes of mice during fetal development.
abstract: The expression patterns of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) in fetal Leydig cells were compared by using immunohistochemistry. While StAR immunoreactivity was detected during the first steps of testis differentiation, SBP expression was detected slightly later. The timing of SBP expression closely correlated with that of the testosterone surge, an event which is known to induce masculinization. Our results suggest that SBP plays an important role in male sexual development via interactions with StAR.
authors.affiliation: Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan. warita@med.kagawa-u.ac.jp
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Warita
authors.forename: Tomoko
authors.initials: T
authors.lastname: Mitsuhashi
authors.forename: Shiho
authors.initials: S
authors.lastname: Fukui
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Ohta
authors.forename: Shingo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Takanori
authors.initials: T
authors.lastname: Miki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Teruo
authors.initials: T
authors.lastname: Sugawara
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Hoshi
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis; D047109:Fetal Development; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D010750:Phosphoproteins / Q000096:biosynthesis*; D013737:Testis / Q000196:embryology / Q000378:metabolism*; D000098682:Steroidogenic Acute Regulatory Protein
chemical_list: D002352:Carrier Proteins; D010750:Phosphoproteins; C585641:StAR-binding protein, mouse; D000098682:Steroidogenic Acute Regulatory Protein