title: Local drug delivery by personalized, intraoperative custom-made implant coating.
abstract: Local administration of drugs can enhance regeneration, prevent infection, or treat postsurgical pain. If used in conjunction with implants, coating strategies should allow the choice of a drug or combination of drugs, their doses, localization, and release due to intraoperative considerations. Current coating technologies lack the ability for personalized medicine strategies. Here, we describe a new intraoperative strategy for drug delivery that allows a personalized approach as local drug delivery by implant coating. A polyvinylalcohol (PVA) patch provides rapid attachment to implant surfaces by cyanoacrylate (CA) adhesives. The CA polymerization was initiated by water uptake of the patch due to exposure to a humid environment. The coating strength depended on the type of the CA, the time of external pressing load and humidification, the properties of the patch and the implant surface. The CA adhesive penetrated and polymerized within the patch without impeding the bioactivity of the embedded molecules or strongly altering the protein release pattern after attachment to the implant surface. The use of CA in combination with the PVA patch proved to be noncytotoxic in vitro. This technology platform opens the possibility for personalized medicine to locally administer drugs due to intraoperative requirements.
authors.affiliation: Julius Wolff Institute, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Trajkovski
authors.forename: A
authors.initials: A
authors.lastname: Petersen
authors.forename: C
authors.initials: C
authors.lastname: Perka
authors.forename: N
authors.initials: N
authors.lastname: Scharnagl
authors.forename: C
authors.initials: C
authors.lastname: Wischke
authors.forename: W
authors.initials: W
authors.lastname: Wagermaier
authors.forename: A
authors.initials: A
authors.lastname: Lendlein
authors.forename: G N
authors.initials: GN
authors.lastname: Duda
mesh_terms: D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003487:Cyanoacrylates / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D006813:Humidity; D007430:Intraoperative Care; D008422:Materials Testing; D011142:Polyvinyl Alcohol / Q000737:chemistry; D057285:Precision Medicine; D019736:Prostheses and Implants; D044968:Regenerative Medicine; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000493:pharmacokinetics; D033081:Shear Strength; D013499:Surface Properties; D014025:Titanium
chemical_list: D020099:Coated Materials, Biocompatible; D003487:Cyanoacrylates; D012710:Serum Albumin, Bovine; D011142:Polyvinyl Alcohol; D014025:Titanium
keywords: cyanoacrylate adhesive; drug delivery; implant coating; intraoperative; polyvinylalcohol