title: Primary Hodgkin lymphoma of the central nervous system: two case reports and review of the literature.
abstract: CNS involvement by systemic Hodgkin lymphoma (HL) is quite rare, but the disease limited to the CNS is an exceptionally rare entity. The incidence of CNS-HL has been estimated at 0.2-0.5% of cases, but a more recent study has modified that figure to less than 0.02%. Like the conventional form, the diagnosis of primary CNS-HL rests upon distinct morphological and immunohistochemical characteristics, including diagnostic Reed-Sternberg cells, in addition to staging studies demonstrating a lack of disease elsewhere. The paucity of cases in the literature precludes reliable clinical and demographic data, as well as a consensus on treatment and prognosis. We present two cases of primary cerebellar HL, one with 10-year follow-up, and a relevant review of the literature.
authors.affiliation: Department of Pathology, University of South Florida, Tampa, Florida, USA; Tampa General Hospital, Tampa, Florida, USA.
authors.forename: Jesse Lee
authors.initials: JL
authors.lastname: Kresak
authors.forename: Johnny
authors.initials: J
authors.lastname: Nguyen
authors.forename: Kondi
authors.initials: K
authors.lastname: Wong
authors.forename: Richard
authors.initials: R
authors.lastname: Davis
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology*; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008297:Male
keywords: CNS Hodgkin; CNS lymphoma; Hodgkin lymphoma; Reed Sternberg; cerebellar lymphoma