title: Acute renal failure associated with diphosphonic acid (HEDP): a case report.
abstract: A 26-year-old man with no significant past medical history presented to emergency department 1 hr after ingesting approximately 200 ml of HEDP 2010 organophosphoric acid corrosion inhibitor. He had normal vital signs, physical examination and biochemical parameters. After 24 hr, he developed nausea with a decreased urine output. While his blood urea nitrogen, creatinine and uric acid levels increased to 36 mg/dl, 3.87 mg/dl, and 8.4 mg/dl, respectively; his serum calcium and phosphorus levels decreased to 7.4 mg/dl and 1.4 mg/dl, respectively. He had proteinuria, glucosuria, leukocyturia and high phosphorus excretion in the urine. On ultrasonographic examination, the kidneys were slightly enlarged and edematous. On the third day of hospitalization, creatinine level increased to 8.81 mg/dl and metabolic acidosis developed. He underwent to hemodialysis therapy and renal functions improved uneventfully.
  
  
  CONCLUSIONS
  This case represents an example of acute renal failure developed and recovering uneventfully after unintentionally ingestion of a bisphosphonate used in industry.
authors.affiliation: Fatih Sultan Mehmet Education and Research Hospital, Department of Internal Medicine, Istanbul, Turkey. alemoz2004@yahoo.com
authors.forename: Ali
authors.initials: A
authors.lastname: Ozdemir
authors.forename: Aysegül
authors.initials: A
authors.lastname: Dalbeler
authors.forename: Aslı
authors.initials: A
authors.lastname: Bilen
authors.forename: Can
authors.initials: C
authors.lastname: Sevinc
authors.forename: Elvan
authors.initials: E
authors.lastname: Isık
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy*; D000328:Adult; D001806:Blood Urea Nitrogen; D004636:Emergency Service, Hospital; D012968:Etidronic Acid / Q000506:poisoning*; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D006435:Renal Dialysis / Q000379:methods*; D018570:Risk Assessment; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D012968:Etidronic Acid