title: Synthesis of ligand-functionalized water-soluble [18F]YF3 nanoparticles for PET imaging.
abstract: We report a simple, efficient synthesis of novel (18)F-labeled imaging agents based on YF3 nanoparticles. Targeting ligands and antitumor drug molecules can be introduced onto the YF3 nanoparticles in a one-pot synthesis. The (18)F-labeling reaction proceeds in aqueous solutions at room temperature with excellent radiolabeling yields (>80%) in a very short time (5-10 min). (18)F-labeled YF3 nanoparticles displayed high stability in mouse and human serum, and their application for mapping lymph nodes in live rats after local injection has also been demonstrated.
authors.affiliation: Stanford Molecular Imaging Program (MIPS), Department of Radiology, Stanford University, Stanford, CA 94305-5484, USA. xiongliqin@sjtu.edu.cn
authors.forename: Liqin
authors.initials: L
authors.lastname: Xiong
authors.forename: Bin
authors.initials: B
authors.lastname: Shen
authors.forename: Deepak
authors.initials: D
authors.lastname: Behera
authors.forename: Sanjiv S
authors.initials: SS
authors.lastname: Gambhir
authors.forename: Frederick T
authors.initials: FT
authors.lastname: Chin
authors.forename: Jianghong
authors.initials: J
authors.lastname: Rao
mesh_terms: D000818:Animals; D005459:Fluorides / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D008024:Ligands; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*; D051381:Rats; D012995:Solubility; D014407:Tumor Cells, Cultured; D014867:Water / Q000737:chemistry; D015019:Yttrium / Q000737:chemistry*
chemical_list: D005462:Fluorine Radioisotopes; D008024:Ligands; D014867:Water; D015019:Yttrium; D005459:Fluorides