title: Mifepristone improves chemo-radiation response in glioblastoma xenografts.
abstract: BACKGROUND
  We have investigated the ability of Mifepristone, an anti-progestin and anti-glucocorticoid drug, to modulate the antitumor effect of current standard clinical treatment in glioblastoma xenografts.
  
  
  METHODS
  The effect of radiation alone or combined with Mifepristone and Temozolamide was evaluated on tumor growth in glioblastoma xenografts, both in terms of preferentially triggering tumor cell death and inhibiting angiogenesis. Tumor size was measured once a week using a caliper and tumor metabolic-activity was carried out by molecular imaging using a microPET/CT scanner. The effect of Mifepristone on the expression of angiogenic factors after concomitant radio-chemotherapy was determined using a quantitative real-time PCR analysis of VEGF gene expression.
  
  
  RESULTS
  The analysis of the data shows a significant antitumoral effect by the simultaneous administration of radiation-Mifepristone-Temozolamide in comparison with radiation alone or radiation-Temozolamide.
  
  
  CONCLUSIONS
  Our results suggest that Mifepristone could improve the efficacy of chemo-radiotherapy in Glioblastoma. The addition of Mifepristone to standard radiation-Temozolamide therapy represents a potential approach as a chemo-radio-sensitizer in treating GBMs, which have very limited treatment options.
authors.affiliation: Instituto Nacional de Cancerología, Subdirección de Investigación Básica, Av, San Fernando No, 22, Tlalpan 14000, Apartado Postal, 22026, México, DF, Mexico. pgarcia_lopez@yahoo.com.mx.
authors.forename: Monserrat
authors.initials: M
authors.lastname: Llaguno-Munive
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Medina
authors.forename: Rafael
authors.initials: R
authors.lastname: Jurado
authors.forename: Mario
authors.initials: M
authors.lastname: Romero-Piña
authors.forename: Patricia
authors.initials: P
authors.lastname: Garcia-Lopez