title: Thyroid hormones-mediated effects of insulin on antioxidant enzymes from diabetic rat hearts.
abstract: Free radicals, oxidative stress, and antioxidants have become commonly used terms in modern discussion of disease mechanisms. Accumulation of evidence suggests that toxic oxygen-derived reactive free radicals (superoxide, peroxide and hydroxyl radicals) play a crucial role in etiology of diabetes and its complication. Thus, it was aimed to determine the role of thyroid hormones in reversal of antioxidatant enzyme activities and lipid peroxidation alterations observed in experimentally induced diabetic rat hearts. The present study investigates the antioxidant enzyme activities such as SOD, CAT, GSH-Px and lipid peroxidation products in cardiac tissues of streptozotosin (STZ)-induced diabetic rats before and after thyroidectomy. Our results showed that CAT, GPx enzyme activities and FOX, MDA levels were increased (p<0.05) during diabetes, hypothyroidism and hypothyroidism with diabetes, which can be regulated in different percentages with treatment of insulin and various doses of thyroid hormone ((p<0.05). In conclusion, in this study, the possible contribution of thyroid hormones to the insulin effect of normalizing the induced diabetic changes in cardiac tissue and serum of rat has been seen (Tab. 5, Ref. 32).
authors.affiliation: Celal Bayar University School of Health, Manisa, Turkey. fundakosova@gmail.com
authors.forename: F
authors.initials: F
authors.lastname: Kosova
authors.forename: N
authors.initials: N
authors.lastname: Altan
authors.forename: A
authors.initials: A
authors.lastname: Sepici
authors.forename: A
authors.initials: A
authors.lastname: Engin
authors.forename: N
authors.initials: N
authors.lastname: Kocamanoglu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*; D013963:Thyroid Hormones / Q000494:pharmacology*; D013965:Thyroidectomy
chemical_list: D000975:Antioxidants; D007328:Insulin; D013963:Thyroid Hormones; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase