title: Orosomucoid, a new biomarker in the association between obesity and periodontitis.
abstract: Epidemiological data indicate an association between periodontitis and obesity. The biological mechanisms of this relationship remain unclear. A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common systemic inflammatory markers in 32 morbidly obese patients recruited in a Clinical Nutrition department. Periodontal condition was evaluated using pocket depth (PD) measurement, a classical clinical marker of ongoing periodontitis. Major periodontal risk factors were recorded (age, gender, diabetes and smoking status), as well as plasma levels of inflammatory markers (CRP, orosomucoid, IL-6) and adipokines (adiponectin, leptin). All patients included in the sample exhibited evidence of periodontitis, 16 of whom were diagnosed as having severe disease. Adjusted logistic regression analysis indicated that the severity of periodontitis was associated with the plasma level of orosomucoid (p<0.04) after adjustment for age, gender and smoking. Our study thus suggests that the severity of periodontitis, in morbidly obese patients, is associated with the increase of orosomucoid levels.
authors.affiliation: Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7-Denis Diderot University, U.F.R. of Odontology, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Rangé
authors.forename: Christine
authors.initials: C
authors.lastname: Poitou
authors.forename: Adrien
authors.initials: A
authors.lastname: Boillot
authors.forename: Cécile
authors.initials: C
authors.lastname: Ciangura
authors.forename: Sandrine
authors.initials: S
authors.lastname: Katsahian
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Lacorte
authors.forename: Sébastien
authors.initials: S
authors.lastname: Czernichow
authors.forename: Olivier
authors.initials: O
authors.lastname: Meilhac
authors.forename: Philippe
authors.initials: P
authors.lastname: Bouchard
authors.forename: Catherine
authors.initials: C
authors.lastname: Chaussain
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000150:complications*; D009961:Orosomucoid / Q000378:metabolism*; D010518:Periodontitis / Q000097:blood* / Q000150:complications* / Q000473:pathology; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D009961:Orosomucoid; D002097:C-Reactive Protein