title: A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils.
abstract: IL-33, a proposed alarmin, stimulates innate immune cells and Th2 cells to produce IL-13 and is rapidly upregulated upon antigen exposure in murine helminth infection. The human IL-33 response to helminth antigen was analysed in Malians infected with Schistosoma haematobium by disrupting parasite integrity via chemotherapy. Plasma IL-33 was measured pretreatment, and 24 h and 9 weeks post-treatment. At 24 h post-treatment, IL-33 levels were low. Nine week post-treatment IL-33 levels were elevated and were associated with an increase in intracellular IL-13 in eosinophils. Up-regulation of intracellular IL-13 in eosinophils was also associated with eosinophil expression of ST2L, the IL-33 receptor. IL-33 may play an important downstream role in the human response to schistosome adult worm antigen exposure.
authors.affiliation: Department of Pathology, University of Cambridge, Cambridge, UK. sw320@cam.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Wilson
authors.forename: F M
authors.initials: FM
authors.lastname: Jones
authors.forename: H K M
authors.initials: HK
authors.lastname: Fofana
authors.forename: A
authors.initials: A
authors.lastname: Landouré
authors.forename: G
authors.initials: G
authors.lastname: Kimani
authors.forename: J K
authors.initials: JK
authors.lastname: Mwatha
authors.forename: M
authors.initials: M
authors.lastname: Sacko
authors.forename: B J
authors.initials: BJ
authors.lastname: Vennervald
authors.forename: D W
authors.initials: DW
authors.lastname: Dunne
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004804:Eosinophils / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D018793:Interleukin-13 / Q000097:blood* / Q000276:immunology; D000067596:Interleukin-33; D015848:Interleukin-5 / Q000097:blood / Q000276:immunology; D007378:Interleukins / Q000097:blood* / Q000276:immunology; D008297:Male; D011223:Praziquantel / Q000627:therapeutic use; D011956:Receptors, Cell Surface / Q000097:blood; D012548:Schistosoma haematobium / Q000276:immunology; D012553:Schistosomiasis haematobia / Q000188:drug therapy / Q000276:immunology*; D012556:Schistosomicides / Q000627:therapeutic use; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D000947:Antigens, Helminth; C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D018793:Interleukin-13; D000067596:Interleukin-33; D015848:Interleukin-5; D007378:Interleukins; D011956:Receptors, Cell Surface; D012556:Schistosomicides; D011223:Praziquantel
keywords: IL-13; IL-33; ST2; eosinophils; helminth; human; schistosomiasis