title: Availability of intravenous lipid emulsion therapy on endosulfan-induced cardiovascular collapse.
abstract: Acute Endosulfan poisoning is associated with a high mortality rate in humans, and can exceed 30% [Moon JM, Chun BJ. Acute endosulfan poisoning: a retrospective study. Hum Exp Toxicol 2009;28:309-16]. Prophylactic anticonvulsant therapy for symptomatic patients and aggressive treatment for seizures may limit morbidity, but, no effective antidote is available [Moses V, Peter JV. Acute intentional toxicity: endosulfan and other organochlorines. Clin Toxicol (Phila) 2010;48:539-44]. However, endosulfan poisoning is often completely reversible with the appropriate management [Karatas AD, Aygun D, Baydin A. Characteristics of endosulfan poisoning: a study of 23 cases. Singapore Med J 2006;47:1030-2]. Intravenous lipid emulsion (ILE) may be a useful in treatment of lipophilic medication overdoses as an adjunct to antidotal therapy [Rothschild L, Berns S, Oswald S, et al. Intravenous lipid emulsion in clinical toxicology. Scand J Trauma Resusc Emerg Med 2010;18:51]. We believe that this is its first reported use in endosulfan toxicity.
authors.affiliation: Department of Emergency Medicine, College of Medicine, Soonchunhyang University, Cheonan, Korea.
authors.forename: Hyung Jun
authors.initials: HJ
authors.lastname: Moon
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Lee
mesh_terms: D004726:Endosulfan / Q000506:poisoning*; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced / Q000628:therapy*; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008875:Middle Aged; D013405:Suicide
chemical_list: D005217:Fat Emulsions, Intravenous; D007306:Insecticides; D004726:Endosulfan