title: Extracorporeal pulmonary support in severe pulmonary failure in adults: a treatment rediscovered.
abstract: BACKGROUND
  Severe, acute respiratory failure in adults still carries a high mortality. In recent years, improved pulmonary support techniques have been used increasingly alongside conventional treatment. About 1000 such treatments are performed in Germany annually, and the number is rising rapidly. The two types of systems currently in use involve venovenous extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide elimination.
  
  
  METHODS
  The underlying principles, technical implementation, efficacy, and adverse effects of the new techniques are summarized in the light of a selective review of the literature, supplemented by the authors' personal experience. Recommendations are given for clinical use.
  
  
  RESULTS
  Currently, only limited high-quality data (from prospective randomized trials) are available to support the use of either of these techniques in adults. Veno-venous ECMO systems can effectively secure gas exchange in patients with severe respiratory failure, with experienced centers reporting survival rates from 63% to 75%. Either pump-free arteriovenous systems or low-flow ECMO systems can be used for extracorporeal carbon dioxide elimination. Complications can be serious or life-threatening and must, therefore, be rapidly recognized and treated: these include vascular injury during cannulation, venous thrombosis in a cannulated vessel, an increased hemorrhagic tendency, and thrombocytopenia.
  
  
  CONCLUSIONS
  Modern miniaturized pulmonary support systems enable protective mechanical ventilation with low tidal volumes, reduce ventilator-associated lung injury, and can improve survival rates in critically ill patients with a manageable adverse effect profile.
authors.affiliation: Department of Internal Medicine II, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany. thomas.mueller@klinik.uni-regensburg.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Müller
authors.forename: Thomas
authors.initials: T
authors.lastname: Bein
authors.forename: Alois
authors.initials: A
authors.lastname: Philipp
authors.forename: Bernhard
authors.initials: B
authors.lastname: Graf
authors.forename: Christof
authors.initials: C
authors.lastname: Schmid
authors.forename: Günter
authors.initials: G
authors.lastname: Riegger
mesh_terms: D000208:Acute Disease; D002245:Carbon Dioxide / Q000097:blood* / Q000302:isolation & purification*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation* / Q000379:methods*; D006440:Hemofiltration / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D012131:Respiratory Insufficiency / Q000097:blood / Q000534:rehabilitation*
chemical_list: D002245:Carbon Dioxide