title: The origins of allostery: from personal memories to material for the future.
abstract: This introductory text evokes personal memories about the origins and definition of the word allosteric that is meant to qualify an "indirect" interaction between topographically and stereospecifically distinct sites, mediated by a discrete and reversible conformational change of the protein. The allosteric transition paradigm adds a new dimension and creates new openings to understanding receptors, signal transduction and drug design.
authors.affiliation: Collège de France and Institut Pasteur, Paris, France. changeux@noos.fr
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Changeux
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D015195:Drug Design; D025461:Feedback, Physiological; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008954:Models, Biological; D011978:Receptors, Nicotinic / Q000378:metabolism
chemical_list: D011978:Receptors, Nicotinic