title: Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis).
abstract: BACKGROUND
  In an attempt to explore cynomolgus monkeys as an animal model for Alzheimer's disease, the present study focused on the Alzheimer's biomarkers beta amyloid 1-42 (Aβ42 ) in serum, and total tau (t-tau) and phosphorylated tau (p-tau) levels in cerebrospinal fluid.
  
  
  METHODS
  We measured biomarker levels in Young and Aged cynomolgus monkeys and correlated these with performance on three delayed response tasks.
  
  
  RESULTS
  The Aβ42 concentration of the Aged monkeys was significantly lower than in the Young subjects, while the t-tau and p-tau did not significantly differ between the groups. The Young subjects performed significantly better than the Aged individuals on the memory tests. Only Aβ42 levels were significantly correlated with performance in the three delayed response tasks.
  
  
  CONCLUSIONS
  Circulating Aβ42 levels were lower in Aged monkeys and were correlated with inferior performance on delayed response tasks in Aged animals; therefore, both measures may be useful in establishing cynomolgus monkeys as models for studies of AD.
authors.affiliation: Department of Experimental Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
authors.forename: H S
authors.initials: HS
authors.lastname: Darusman
authors.forename: D
authors.initials: D
authors.lastname: Sajuthi
authors.forename: O
authors.initials: O
authors.lastname: Kalliokoski
authors.forename: K R
authors.initials: KR
authors.lastname: Jacobsen
authors.forename: J
authors.initials: J
authors.lastname: Call
authors.forename: S J
authors.initials: SJ
authors.lastname: Schapiro
authors.forename: A
authors.initials: A
authors.lastname: Gjedde
authors.forename: K S P
authors.initials: KS
authors.lastname: Abelson
authors.forename: J
authors.initials: J
authors.lastname: Hau
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000097:blood* / Q000134:cerebrospinal fluid / Q000523:psychology*; D016229:Amyloid beta-Peptides / Q000097:blood; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D004195:Disease Models, Animal; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D008568:Memory; D010446:Peptide Fragments / Q000097:blood; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins