title: Epizootic neoplasia of the lateral line system of lake trout (Salvelinus namaycush) in New York's Finger Lakes.
abstract: This article documents an epizootic of inflammation and neoplasia selectively affecting the lateral line system of lake trout (Salvelinus namaycush) in 4 Finger Lakes in New York from 1985 to 1994. We studied more than 100 cases of this disease. Tumors occurred in 8% (5/64) of mature and 21% (3/14) of immature lake trout in the most severely affected lake. Lesions consisted of 1 or more neoplasm(s) in association with lymphocytic inflammation, multifocal erosions, and ulcerations of the epidermis along the lateral line. Lesions progressed from inflammatory to neoplastic, with 2-year-old lake trout showing locally extensive, intense lymphocytic infiltrates; 2- to 3-year-old fish having multiple, variably sized white masses up to 3 mm in diameter; and fish over 5 years old exhibiting 1 or more white, cerebriform masses greater than 1 cm in diameter. Histologic diagnoses of the tumors were predominantly spindle cell sarcomas or benign or malignant peripheral nerve sheath neoplasms, with fewer epitheliomas and carcinomas. Prevalence estimates did not vary significantly between sexes or season. The cause of this epizootic remains unclear. Tumor transmission trials, virus isolation procedures, and ultrastructural study of lesions failed to reveal evidence of a viral etiology. The Finger Lakes in which the disease occurred did not receive substantially more chemical pollution than unaffected lakes in the same chain during the epizootic, making an environmental carcinogen an unlikely primary cause of the epizootic. A hereditary component, however, may have contributed to this syndrome since only fish of the Seneca Lake strain were affected.
authors.affiliation: Department of Microbiology, 220 Nash Hall, Oregon State University, Corvallis, OR 97331, USA. spitsbej@onid.orst.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Spitsbergen
authors.forename: S A
authors.initials: SA
authors.lastname: Frattini
authors.forename: P R
authors.initials: PR
authors.lastname: Bowser
authors.forename: R G
authors.initials: RG
authors.lastname: Getchell
authors.forename: L L
authors.initials: LL
authors.lastname: Coffee
authors.forename: M J
authors.initials: MJ
authors.lastname: Wolfe
authors.forename: J P
authors.initials: JP
authors.lastname: Fisher
authors.forename: S J
authors.initials: SJ
authors.lastname: Marinovic
authors.forename: K E
authors.initials: KE
authors.lastname: Harr
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000662:veterinary; D058872:Epidemics / Q000662:veterinary; D005260:Female; D005393:Fish Diseases / Q000453:epidemiology / Q000473:pathology*; D005618:Fresh Water; D006257:Head / Q000473:pathology; D007150:Immunohistochemistry / Q000662:veterinary; D007249:Inflammation / Q000662:veterinary; D060106:Lakes; D053403:Lateral Line System / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D009369:Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D009518:New York / Q000453:epidemiology; D015995:Prevalence; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D014337:Trout
chemical_list: D012194:RNA-Directed DNA Polymerase
keywords: Finger Lakes; electron microscopy; epizootic; fish; lake trout; lateral line; neoplasia