title: The SLC41 family of MgtE-like magnesium transporters.
abstract: Magnesium is one of the most predominant intracellular divalent cations and is requisite to the regulation of a diverse array of cellular functions. Although accumulating data from multiple studies have begun to illuminate the critical role(s) played by Mg(2+) transporters in pathways involved in cell signaling, metabolism, growth and proliferation, there is still a lack of understanding of the underlying molecular mechanisms that govern those various functions. In this review, we focus on the recently described SLC41 family of magnesium transporters, two members of which have been shown to mediate Mg(2+) uptake and transport, and highlight what is known about their expression, localization, and function, as well as their roles and contributions to cellular Mg(2+) transport.
authors.affiliation: Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101, USA. slc41a2@gmail.com
authors.forename: Jaya
authors.initials: J
authors.lastname: Sahni
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Scharenberg
mesh_terms: D000595:Amino Acid Sequence; D027682:Cation Transport Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D011487:Protein Conformation; D016415:Sequence Alignment; D015398:Signal Transduction / Q000235:genetics
chemical_list: D027682:Cation Transport Proteins; C476304:SLC41A1 protein, human; D008274:Magnesium