title: Can chitotriosidase be a surrogate marker for invasive fungal disease?
abstract: BACKGROUND
  Chitotriosidase (CHT) enzyme has been known to be secreted from the activated macrophages. We infer with these data that CHT activity is an indicator for the defence.
  
  
  METHODS
  In this study, we evaluated CHT levels in both neutropenic and non neutropenic patients. CHT enzyme activity was measured and compared to each other groups.
  
  
  RESULTS
  Chitotriosidase levels were found to be significantly higher in neutropenic patients with candidemia.
  
  
  CONCLUSIONS
  In the comparison between neutropenic and non neutropenic patients, there was a significant difference for CHT levels. The use of this enzyme as a surrogate marker for candidemias were evaluated in neutropenic and non neutropenic patients.
authors.affiliation: Gulhane Military Medical Academy Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey. coskunomer23@hotmail.com
authors.forename: O
authors.initials: O
authors.lastname: Coskun
authors.forename: M
authors.initials: M
authors.lastname: Ozturk
authors.forename: H
authors.initials: H
authors.lastname: Erdem
authors.forename: R
authors.initials: R
authors.lastname: Gumral
authors.forename: H
authors.initials: H
authors.lastname: Yaman
authors.forename: A
authors.initials: A
authors.lastname: Karakas
authors.forename: S
authors.initials: S
authors.lastname: Kilic
authors.forename: C P
authors.initials: CP
authors.lastname: Eyigun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D016470:Bacteremia / Q000097:blood / Q000150:complications; D015415:Biomarkers; D058387:Candidemia / Q000097:blood* / Q000150:complications / Q000201:enzymology / Q000276:immunology; D060085:Coinfection; D005260:Female; D005656:Fungal Proteins / Q000097:blood*; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D016867:Immunocompromised Host; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D009503:Neutropenia / Q000097:blood / Q000139:chemically induced; D011237:Predictive Value of Tests; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005656:Fungal Proteins; D006596:Hexosaminidases; C086400:chitotriosidase