title: Nutrient-based dietary patterns of head and neck squamous cell cancer: a factor analysis in Uruguay.
abstract: OBJECTIVE
  The aim of this study was to investigate the association between nutrient-based dietary patterns and squamous cell cancers of the head and neck.
  
  
  METHODS
  We used a case-control study which included 548 cases and 548 controls. From these participants, we derived 23 nutrients and they were then submitted to a factorability analysis in order to conduct a principal component factor analysis.
  
  
  RESULTS
  We were able to identify four nutrient-derived patterns. The first pattern (meat-based pattern) was positively associated with squamous cell cancer of the head and neck (OR 2.85, 95 % CI 1.81-4.15), whereas the third pattern (fruit-based) was strongly protective (OR 0.43, 95 % CI 0.27-0.63). The other nutrient patterns were also significantly associated with head and neck squamous cell carcinoma with minor ORs.
  
  
  CONCLUSIONS
  Both patterns suggest that red meat and fruits are major factors in the etiology of head and neck squamous cell cancer, replicating previous studies in the field.
authors.affiliation: Epidemiology Group, Department of Pathology, School of Medicine, Avenida Brasil 3080 department 402, 11300, Montevideo, Uruguay.
authors.forename: Hugo
authors.initials: H
authors.lastname: Deneo-Pellegrini
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Eduardo
authors.initials: E
authors.lastname: De Stefani
authors.forename: Pelayo
authors.initials: P
authors.lastname: Correa
authors.forename: Alvaro L
authors.initials: AL
authors.lastname: Ronco
authors.forename: Gisele
authors.initials: G
authors.lastname: Acosta
authors.forename: María
authors.initials: M
authors.lastname: Mendilaharsu
authors.forename: Cecilia
authors.initials: C
authors.lastname: Silva
authors.forename: María E
authors.initials: ME
authors.lastname: Luaces
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D004032:Diet / Q000706:statistics & numerical data*; D005163:Factor Analysis, Statistical; D005502:Food / Q000706:statistics & numerical data*; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D008460:Meat; D008875:Middle Aged; D000077195:Squamous Cell Carcinoma of Head and Neck; D011795:Surveys and Questionnaires; D014583:Uruguay / Q000453:epidemiology