title: Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide.
abstract: Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free "click" approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.
authors.affiliation: Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum (BMWZ) der Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany;
authors.forename: Lena
authors.initials: L
authors.lastname: Möller
authors.forename: Christian
authors.initials: C
authors.lastname: Hess
authors.forename: Jiří
authors.initials: J
authors.lastname: Paleček
authors.forename: Yi
authors.initials: Y
authors.lastname: Su
authors.forename: Axel
authors.initials: A
authors.lastname: Haverich
authors.forename: Andreas
authors.initials: A
authors.lastname: Kirschning
authors.forename: Gerald
authors.initials: G
authors.lastname: Dräger
keywords: click chemistry; growth factor; nitrenes; plasma chemistry; poly(4-methylpent-1-ene); surface modification