title: Spectral and Eukaryotic DNA degradation studies for Ni(II), Pd(II), Pt(IV), Cu(II) and UO2(2+) complexes derived from thiouracil derivative.
abstract: A derivative of thiouracil ligand was prepared. Ni(II), Pd(II), Pt(IV), Cu(II) and UO2(2+) complexes were prepared. The elemental and different spectral tools were used for their characterization. A binegative tetradentate mode is the general coordination behavior of the ligand towards all metal ions used. The structural geometries were varied from square-planer (Pt, Pd(II)), square-pyramidal (Cu(II)) and octahedral (UO2(2+)). The geometry optimization implementing the hyperChem reveals that the Cu(II) complex is the most stable one. The thermogravimetric analysis supports the presence of solvent molecules attached with most complexes. The biological investigation was studied on different microorganisms as gram-positive, gram-negative and fungia. The Ni(II) complex shows the most toxic activity towards most organisms used. The degradation effect of DNA was studied by the use of investigated compounds and reveal that the Ni(II) and Pd(II) complexes are the most effective on the DNA degradation.
authors.affiliation: Chemistry Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia. dr.khlood@hotmail.com
authors.forename: Khlood S
authors.initials: KS
authors.lastname: Abou-Melha
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002417:Cattle; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009181:Mycoses / Q000188:drug therapy; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology; D010984:Platinum / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013889:Thiouracil / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D008024:Ligands; D010984:Platinum; D013889:Thiouracil; D010165:Palladium; D003300:Copper; D009532:Nickel; D004247:DNA; C427203:calf thymus DNA