title: Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
abstract: Two new prenylated indole alkaloids, 17-epi-notoamides Q and M (1 and 2), and two new phenyl ether derivatives, cordyols D and E (9 and 13), together with 10 known compounds (3-8, 10-12, 14) were isolated from a marine-derived Aspergillus sp. fungus. Among them, 1/5 and 2/4 were pairs of epimers. The planar structures and absolute configurations of the new compounds were determined by extensive NMR spectroscopic data as well as CD spectra. The absolute configuration of 3 was confirmed by single-crystal X-ray diffraction analysis for the first time. All isolated metabolites (1-14) and eight synthetic phenyl ether derivatives (12a, 14a-14g) were evaluated for their antibacterial activities in vitro. The polybromide phenyl ether 14g showed pronounced antibacterial activity against Staphylococcus epidermidis with an MIC value of 0.556 μM, stronger than that of the positive control ciprofloxacin (MIC = 3.13 μM).
authors.affiliation: Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Fu
authors.forename: Ru-Fang
authors.initials: RF
authors.lastname: Xu
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Zheng
authors.forename: Dong-Lin
authors.initials: DL
authors.lastname: Zhao
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: She
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: C582584:17-epi-notoamide M; C582583:17-epi-notoamide Q; D000900:Anti-Bacterial Agents; D026121:Indole Alkaloids