title: Evaluation of essential and toxic trace elements in pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
abstract: Pseudoexfoliation syndrome (PEX), an age-related disorder of the eye, is associated with significant ophthalmic morbidity and can lead to pseudoexfoliation glaucoma (PEG). The etiology of this disorder has not been clearly understood. Trace elements have been suggested to have roles in the pathogenesis of several disorders. This study aimed to determine whether trace element levels have a role in the development of PEX and/or PEG. Levels of zinc (Zn), copper (Cu), selenium (Se), manganese (Mn), chromium (Cr), cobalt (Co), molybdenum (Mo), nickel (Ni), vanadium (V), arsenic (As), aluminum (Al), mercury (Hg), cadmium (Cd), and strontium (Sr) were determined in serum samples of 32 cases of PEX, 30 cases of PEG, and 32 control subjects using inductively coupled plasma-mass spectrometry. Mn, Mo, and Hg concentrations were found to be significantly increased in patients with PEX. Logistic regression revealed Mn and Hg as the strongest determinants of PEX and Mo as the strongest determinant of PEG in the studied Turkish subjects. Levels of Mn, Cr, Co, Mo, Al, Hg, Sr, Ni, V, and As were determined for the first time in these ophthalmological disorders. Increased levels of serum Mn, Mo, and Hg suggest a possible role of these elements in the pathobiology of PEX.
authors.affiliation: Ophthalmology Department, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Osman Melih
authors.initials: OM
authors.lastname: Ceylan
authors.forename: Birsen
authors.initials: B
authors.lastname: Can Demirdöğen
authors.forename: Tarkan
authors.initials: T
authors.lastname: Mumcuoğlu
authors.forename: Osman
authors.initials: O
authors.lastname: Aykut
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D017889:Exfoliation Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D014131:Trace Elements / Q000097:blood* / Q000633:toxicity
chemical_list: D014131:Trace Elements