title: Optical imaging of the spontaneous depolarization wave in the mouse embryo: origins and pharmacological nature.
abstract: Spontaneous embryonic movements, called embryonic motility, are produced by correlated spontaneous activity in the cranial and spinal nerves, which is driven by brainstem and spinal networks. Using optical imaging with a voltage-sensitive dye, we revealed previously in the chick and rat embryos that this correlated activity is a widely propagating wave of neural depolarization, which we termed the depolarization wave. One important consideration is whether a depolarization wave with similar characteristics occurs in other species, especially in different mammals. Here, we provide evidence for the existence of the depolarization wave in the mouse embryo by summarizing spatiotemporal characteristics and pharmacological natures of the widely propagating wave activity. The findings show that a synchronized wave with common characteristics is expressed in different species, suggesting its fundamental roles in neural development.
authors.affiliation: Department of Health and Nutrition, Kanto Gakuin University, College of Human and Environmental Studies, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Momose-Sato
authors.forename: Katsushige
authors.initials: K
authors.lastname: Sato
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects* / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D009434:Neural Pathways / Q000187:drug effects / Q000196:embryology*; D055495:Neurogenesis / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000494:pharmacology*; D061848:Optical Imaging / Q000379:methods; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects / Q000196:embryology / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents