title: Effect of Infliximab on the UVB-Induced Apoptosis of Keratinocytes Infected by HPV38 E6/E7.
abstract: The question of the effect of anti-TNF-alpha in skin carcinogenesis is especially relevant in view of the increased use of these drugs for the treatment of autoinflammatory immune diseases. Since ultraviolet radiation and human papillomavirus are involved in skin carcinogenesis, we wished to investigate the effect of TNF-alpha antagonists on the UVB-induced apoptosis of keratinocytes infected by HPV38. Our results indicate that anti-TNF agent, infliximab, does not contribute to the survival of HPV38-transduced keratinocytes with UVB-induced DNA damages.
authors.affiliation: Molecular and Cell Biology Laboratory, Université de Franche Comté, EA3181, SFR FED4234, Besançon, France ; Department of Dermatology, Centre Hospitalier Universitaire, 25030 Besançon, France.
authors.forename: François
authors.initials: F
authors.lastname: Aubin
authors.forename: Tarik
authors.initials: T
authors.lastname: Gheit
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Prétet
authors.forename: Massimo
authors.initials: M
authors.lastname: Tommasino
authors.forename: Christiane
authors.initials: C
authors.lastname: Mougin