title: The effects of endovenous radiofrequency ablation  on coagulation and the vein wall in an experimental  canine model.
abstract: Endovenous radiofrequency ablation (RFA) has been introduced as a less invasive alternative to traditional surgery for varicose veins, but vein thrombosis after RFA remains a concern. This study investigated the influence of endovenous RFA on coagulable states of canine blood, and changes in the vein wall and lumen. Eight canines underwent RFA of the iliac-femoral vein. Levels of plasma granule membrane protein-140, tissue plasminogen activator and plasminogen activator inhibitor-1 increased at different time points after RFA, which were monitored by enzyme-linked immunosorbent assay. Venography after ablation showed that there was left iliac-femoral vein occlusion in three canines and vein stenosis in the remaining five. Histological examination revealed intimal injury and inflammatory cell infiltration of the vessel wall. Our findings suggest that RFA is an effective microinvasive technique, which can result in a hypercoagulable state, with venous thrombosis and stenosis.
authors.affiliation: Department of Interventional Radiology, Nanjing First Hospital affiliated to Nanjing Medical University, Nanjing, Jiangsu 210006, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Tao
authors.forename: Gu
authors.initials: G
authors.lastname: Jian-ping
authors.forename: He
authors.initials: H
authors.lastname: Xu
authors.forename: Lou
authors.initials: L
authors.lastname: Wen-sheng
authors.forename: Chen
authors.initials: C
authors.lastname: Liang
authors.forename: Chen
authors.initials: C
authors.lastname: Guo-ping
authors.forename: Su
authors.initials: S
authors.lastname: Hao-bo
authors.forename: Song
authors.initials: S
authors.lastname: Jin-hua
mesh_terms: D000818:Animals; D017115:Catheter Ablation; D004285:Dogs; D005268:Femoral Vein / Q000601:surgery; D053685:Laser Therapy; D012501:Saphenous Vein / Q000601:surgery; D016896:Treatment Outcome; D014648:Varicose Veins / Q000601:surgery; D020246:Venous Thrombosis / Q000601:surgery