title: All-trans retinoic acid and late relapses in acute promyelocytic leukemia: very long-term follow-up of the North American Intergroup Study I0129.
abstract: We report a long-term follow-up (median 11.8 years) of the First North American Intergroup Study. 379 patients were randomized to induction with ATRA or to chemotherapy. All complete responders (CR) received consolidation chemotherapy, then randomized to 1 year ATRA or observation. 245 patients received ATRA sometime during the study: 195 (80%) achieved a CR. Nine (4.6%) relapsed late (>3 years from CR), the last occurred after 4.6 years; 7 of them were still alive after 5.5-15 years. In APL patients, late relapses are uncommon, and those who sustain CR >5 years can be considered cured.
authors.affiliation: Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA. douer@mskcc.org
authors.forename: Dan
authors.initials: D
authors.lastname: Douer
authors.forename: Lynette N
authors.initials: LN
authors.lastname: Zickl
authors.forename: Charles A
authors.initials: CA
authors.lastname: Schiffer
authors.forename: Fredrick R
authors.initials: FR
authors.lastname: Appelbaum
authors.forename: James H
authors.initials: JH
authors.lastname: Feusner
authors.forename: Lois
authors.initials: L
authors.lastname: Shepherd
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Willman
authors.forename: Clara D
authors.initials: CD
authors.lastname: Bloomfield
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Paietta
authors.forename: Robert E
authors.initials: RE
authors.lastname: Gallagher
authors.forename: Jae H
authors.initials: JH
authors.lastname: Park
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Rowe
authors.forename: Peter H
authors.initials: PH
authors.lastname: Wiernik
authors.forename: Martin S
authors.initials: MS
authors.lastname: Tallman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D011379:Prognosis; D015996:Survival Rate; D013997:Time Factors; D014212:Tretinoin / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin