title: Multilocus sequence typing of Candida albicans isolates from candidemia and superficial candidiasis in Israel.
abstract: Forty two Candida albicans isolates were collected from clinical samples in Israel. Twenty strains were isolated from blood cultures and 22 from superficial candidiasis. Isolates were typed by MLST analysis. Thirty-seven Diploid Sequence Types (DSTs) were identified. Seventeen isolates (40.5%) displayed new DSTs; 34 (81%) clustered within previously described clades, while nine (19%) did not cluster in any known group. Clonal Complex (CC) 124 was the most prevalent in both candidemia and superficial candidiasis isolates, CC 918 was only found in candidemia strains. To the best of our knowledge, this is the first study analyzing C. albicans clinical isolates from Israel using MLST methodology, possibly pointing to geographic differences in strain distribution.
authors.affiliation: * Public Health Research Institute, New Jersey Medical School-UMDNJ , Newark, NJ , USA.
authors.forename: Ana
authors.initials: A
authors.lastname: Alastruey-Izquierdo
authors.forename: Marina
authors.initials: M
authors.lastname: Mandelblat
authors.forename: Ronen
authors.initials: R
authors.lastname: Ben Ami
authors.forename: David S
authors.initials: DS
authors.lastname: Perlin
authors.forename: Esther
authors.initials: E
authors.lastname: Segal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002176:Candida albicans / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology*; D002675:Child, Preschool; D016000:Cluster Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D007557:Israel; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology / Q000379:methods; D058885:Multilocus Sequence Typing / Q000379:methods*; D016533:Mycological Typing Techniques / Q000379:methods*; D055815:Young Adult