title: EGFR mutational status in penile cancer.
abstract: OBJECTIVE
  No substantial improvement in overall survival has been obtained over the past two decades in penile cancer (PC). Clinical data are available on the role of epidermal growth factor receptors (EGFR) inhibitors in PC but no EGFR mutational analysis has been conducted.
  
  
  METHODS
  We reviewed formalin-fixed, paraffin-embedded blocks of PC at the Pathology Department of the National Cancer Institute since 2000 through 2012 to evaluate activating mutations in the tyrosine kinase domain of EGFR: EGFR E746 - A750 specific deletion in exon 19 and EGFR L858R specific point mutation in exon 21.
  
  
  RESULTS
  Thirty tumor samples were available for our analysis. EGFR was expressed in all samples at immunohistochemistry. Tested mutations were not identified in any of the samples analyzed.
  
  
  CONCLUSIONS
  The most frequent activating EGFR mutations detected in non-small setting lung cancer are absent in penile cancer (PC). Sequencing of the entire EGFR gene in patients with PC may provide useful insights, as its mechanism of overexpression and activation in PC remains unknown.
authors.affiliation: University Federico II, Genitourinary Cancer Section and Rare-Cancer Center, Medical Oncology Division , Napoli , Italy. giuseppedilorenzoncol@hotmail.com
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Lorenzo
authors.forename: Carlo
authors.initials: C
authors.lastname: Buonerba
authors.forename: Gabriella
authors.initials: G
authors.lastname: Gaudioso
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Gigantino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Quarto
authors.forename: Renato
authors.initials: R
authors.lastname: De Domenico
authors.forename: Michele
authors.initials: M
authors.lastname: Caraglia
authors.forename: Rossella
authors.initials: R
authors.lastname: Di Trolio
authors.forename: Paolo A
authors.initials: PA
authors.lastname: Ascierto
authors.forename: Sabino
authors.initials: S
authors.lastname: De Placido
authors.forename: Sisto
authors.initials: S
authors.lastname: Perdonà
authors.forename: Renato
authors.initials: R
authors.lastname: Franco
mesh_terms: D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D009154:Mutation; D010412:Penile Neoplasms / Q000235:genetics* / Q000378:metabolism; D046888:Tissue Array Analysis
chemical_list: D066246:ErbB Receptors