title: Serum uric acid level in patients with relapsing-remitting multiple sclerosis.
abstract: Uric acid (UA) is a hydrophilic antioxidant product associated with multiple sclerosis (MS). We conducted a randomized case-control study to evaluate the serum level of UA in different phases of MS in comparison with levels in a healthy control population. Serum UA was checked in 130 patients with relapsing-remitting MS (85 patients in remitting and 45 patients in relapsing phase) and 50 age-matched controls using a quantitative enzyme-linked immunosorbent assay (ELISA). The mean concentrations of UA in serum was 6.41(±3.18)mg/dL in patients with remitting MS, 4.76(±1.66)mg/dL in patients with relapsing MS and 6.33(±2.94)mg/dL in controls. There was a significant difference between mean UA concentration in relapsing MS and remitting MS (p<0.001), and between patients with relapsing MS and controls (p=0.002); however, the difference between levels for patients in the remitting phase of MS and the control group was not significant (p=0.87). It seems probable that UA has a role in the prevention of disease activity in MS.
authors.affiliation: Department of Neurology, Isfahan University of Medical Sciences, Isfahan Neuroscience Research Center, Isfahan, Iran.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Ashtari
authors.forename: Mohammadali
authors.initials: M
authors.lastname: Bahar
authors.forename: Maryam
authors.initials: M
authors.lastname: Aghaei
authors.forename: Arash
authors.initials: A
authors.lastname: Zahed
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000145:classification; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D014527:Uric Acid