title: Clinical implications from drug-drug and drug-disease interactions in older people.
abstract: This clinical review summarizes the evidence in relation to clinical outcomes from drug-drug and drug-disease interactions in older people. Exposure to drug-drug interactions is associated with increased risk of hospitalization-related outcomes in older people. Drug-disease interactions have been linked with adverse drug interactions and adverse drug events in studies of older people. Although the prevalence of drug-drug and drug-disease interactions is common in older people, there are very limited empirical data on important clinical outcomes from drug-drug and drug-disease interactions. Clinical implications of interactions between drugs and geriatric syndromes such as frailty, falls, cognitive impairment, immobility and urinary incontinence should also be considered in older people.
authors.affiliation: Faculty of Pharmacy and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. danijela.gnjidic@sydney.edu.au
authors.forename: Danijela
authors.initials: D
authors.lastname: Gnjidic
authors.forename: Kristina
authors.initials: K
authors.lastname: Johnell
mesh_terms: D000375:Aging; D004347:Drug Interactions; D006304:Health Status; D006801:Humans; D055553:Prescription Drugs / Q000009:adverse effects*
chemical_list: D055553:Prescription Drugs