title: Preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma.
abstract: BACKGROUND
  The purpose of this study was to evaluate the relationship between preoperative inflammatory markers (neutrophil-lymphocyte ratio and platelet-lymphocyte ratio) and cervical stromal involvement in patients with endometrioid adenocarcinoma.
  
  
  METHODS
  We studied 318 patients with endometrioid adenocarcinoma who underwent comprehensive surgical staging. We used univariate and multivariate analyses of cervical stromal involvement and receiver-operating curves to calculate optimal cutoff values for neutrophil-lymphocyte and platelet-lymphocyte ratios to predict cervical stromal involvement.
  
  
  RESULTS
  The presence of cervical stromal involvement was associated with neutrophil-lymphocyte ratio and platelet-lymphocyte ratio (P = 0.009 and P = 0.031, respectively). Multivariate analysis showed that higher neutrophil-lymphocyte and platelet-lymphocyte ratios independently predicted cervical stromal involvement (odds ratio 3.10, 95% confidence interval 1.10-8.76, P = 0.032, and odds ratio 5.27, 95% confidence interval 1.94-14.35, P = 0.001, respectively). At a threshold of 2.01, the neutrophil-lymphocyte ratio was 71.0% sensitive and 63.8% specific for stromal involvement; at a 172.24 threshold, the platelet-lymphocyte ratio was 48.4% sensitive and 88.9% specific.
  
  
  CONCLUSIONS
  Preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios can help identify the risk of cervical stromal involvement in patients with endometrial cancer. Evaluating these ratios may help select patients who should be particularly watched and tested for cervical stromal involvement.
authors.affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Jia-Xin
authors.initials: JX
authors.lastname: Yang
authors.forename: Dong-Yan
authors.initials: DY
authors.lastname: Cao
authors.forename: Xi-Run
authors.initials: XR
authors.lastname: Wan
authors.forename: Feng-Zhi
authors.initials: FZ
authors.lastname: Feng
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Huang
authors.forename: Keng
authors.initials: K
authors.lastname: Shen
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
keywords: cervical stromal involvement; endometrioid adenocarcinoma; neutrophil-lymphocyte ratio; platelet-lymphocyte ratio