title: Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population.
abstract: Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an important role in IDC progression. The aim of this study was to test frequencies of mitochondrial haplogroups in healthy controls (n=422) and IDC patients (n=304) of a Caucasian Spanish population. To achieve this, ten major European haplogroups were identified. Frequencies and Odds Ratios for the association between IDC and haplogroups were calculated in both groups. We found that compared to healthy controls, the prevalence of haplogroup H was significantly higher in IDC patients (40.0% vs 50.7%, p-value=0.040).
authors.affiliation: Cardiac Biomarkers Group, Research Unit, INIBIC-Complejo Hospitalario Universitario A Coruña, A Coruña, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Caggiano
authors.forename: J
authors.initials: J
authors.lastname: Barallobre-Barreiro
authors.forename: I
authors.initials: I
authors.lastname: Rego-Pérez
authors.forename: M G
authors.initials: MG
authors.lastname: Crespo-Leiro
authors.forename: M J
authors.initials: MJ
authors.lastname: Paniagua
authors.forename: Z
authors.initials: Z
authors.lastname: Grillé
authors.forename: F J
authors.initials: FJ
authors.lastname: Blanco
authors.forename: N
authors.initials: N
authors.lastname: Doménech
mesh_terms: D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000453:epidemiology* / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D004272:DNA, Mitochondrial