title: Diagnostic and prognostic significance of CA IX and suPAR in gastric cancer.
abstract: This study was intended to evaluate the prognostic and diagnostic significance of carbonic anhydrase IX (CA IX) and soluble urokinase plasminogen activator receptor (suPAR) levels in gastric cancer patients. CA IX and suPAR were analyzed from serum and plasma samples of gastric cancer patients. Fifty patients and 34 controls were enrolled. CA IX and suPAR levels were statistically significantly higher in the patient group (patient; 182.5 ± 212.4, control; 47.3 ± 32, P = 0.0001 and patient; 5.74 ± 5.3, control; 2.27 ± 0.77, P = 0.0001, respectively). CA IX and suPAR levels were higher in metastatic subjects (metastatic; 227.1 ± 273.5, non-metastatic; 147.4 ± 144.1, P > 0.05). Prognosis was worse in the patient group with elevated suPAR. CA IX and especially suPAR are correlated with the presence and stage of the disease. High suPAR levels indicate a poorer prognosis in gastric cancer patients.
authors.affiliation: Division of Medical Oncology, Konya Training and Research Hospital, 42100 Konya, Turkey. evrenfidan@yahoo.com
authors.forename: Evren
authors.initials: E
authors.lastname: Fidan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
authors.forename: Feyyaz
authors.initials: F
authors.lastname: Ozdemir
authors.forename: Orhan
authors.initials: O
authors.lastname: Deger
authors.forename: Halil
authors.initials: H
authors.lastname: Kavgaci
authors.forename: S
authors.initials: S
authors.lastname: Caner Karahan
authors.forename: Fazil
authors.initials: F
authors.lastname: Aydin
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000097:blood*; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000097:blood; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases / Q000096:biosynthesis / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055293:Receptors, Urokinase Plasminogen Activator / Q000096:biosynthesis / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D015996:Survival Rate / Q000639:trends; D015854:Up-Regulation / Q000235:genetics
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C524898:PLAUR protein, human; D055293:Receptors, Urokinase Plasminogen Activator; C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases