title: Homeostatic regulation of aging and rejuvenation in the B lineage cells.
abstract: Aging is generally considered a progressive and irreversible process. Age-related alterations in the immune system result in increased susceptibility to infectious diseases and poor responsiveness to vaccination. Recently, several studies have suggested that age-related alterations in hematopoietic and non-hematopoietic tissues can be reversed. In this article we review possible mechanisms for aging in the B lineage and propose a novel hypothesis: altering cellular homeostasis by depletion can reverse aging by reactivating B lymphopoiesis in the bone marrow and rejuvenating the peripheral B cell compartment.
authors.affiliation: The Rappaport Faculty of Medicine and Research Institute, Department of Immunology, Technion-Israel Institute of Technology, Haifa 31096, Israel. melamedd@tx.technion.ac.il
authors.forename: Doron
authors.initials: D
authors.lastname: Melamed
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D019070:Cell Lineage; D006706:Homeostasis; D006801:Humans; D007108:Immune Tolerance; D038041:Lymphopoiesis