title: Synthesis of esters of ginsenoside metabolite M1 and their cytotoxicity on MGC80-3 cells.
abstract: Monoesters of ginsenoside metabolite M1 at the 3-OH, 4-OH and 6-OH positions of the glucose moiety at M1 were synthesized via the reaction of M1 with acyl chloride, or acid-N,N'-diisopropylcarbodiimide in the presence of DMAP. Their structures were fully characterized by spectral methods. The cytotoxicity of these compounds against then MGC80-3 human gastric cancer cell line was also assessed. High inhibitory effects were found at a concentration of 100 μg/mL.
authors.affiliation: College of Medical, Dalian University, Dalian 116622, China. gxjclr@163.com.
authors.forename: Wen-Fang
authors.initials: WF
authors.lastname: Li
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Chen
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Gong
authors.forename: Zheng-Ning
authors.initials: ZN
authors.lastname: Li
authors.forename: Ke-Ke
authors.initials: KK
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002234:Carbodiimides / Q000032:analysis / Q000737:chemistry; D045744:Cell Line, Tumor; D036145:Ginsenosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D011725:Pyridines / Q000032:analysis / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D002234:Carbodiimides; D036145:Ginsenosides; D011725:Pyridines; C417980:4-(dimethylamine)pyridine; C081611:1,3-diisopropylcarbodiimide; C112772:ginsenoside compound K