title: Photocatalytic synthesis of allylic trifluoromethyl substituted styrene derivatives in batch and flow.
abstract: A cobalt-catalyzed photochemical synthesis of allylic trifluoromethanes from styrene derivatives using 2,2,2-trifluoroethyl iodide is described. The method complements existing approaches, providing an alternative bond construction strategy to access these compounds. The process may be conducted in continuous mode in a novel photochemical flow reactor, resulting in a notable productivity increase.
authors.affiliation: Laboratory of Organic Chemistry, ETH-Zürich, HCI H335, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
authors.forename: Lukas M
authors.initials: LM
authors.lastname: Kreis
authors.forename: Simon
authors.initials: S
authors.lastname: Krautwald
authors.forename: Nicole
authors.initials: N
authors.lastname: Pfeiffer
authors.forename: Rainer E
authors.initials: RE
authors.lastname: Martin
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000295:instrumentation / Q000379:methods; D003035:Cobalt / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D055668:Photochemical Processes; D013343:Styrenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C583482:2,2,2-trifluoroethyl iodide; D006845:Hydrocarbons, Fluorinated; D013343:Styrenes; D003035:Cobalt