title: Haemodynamic analysis of the effect of different types of plaques in the left coronary artery.
abstract: OBJECTIVE
  Coronary plaque has been shown to directly affect the blood parameters, however, haemodynamic variations based on the plaque configuration has not been studied. In this study we investigate the haemodynamic effects of various types of plaques in the left coronary bifurcation.
  
  
  METHODS
  Eight types of plaque configurations were simulated and located in various positions in the left main stem, the left anterior descending and left circumflex to produce a >50% narrowing of the coronary lumen. We analyse and characterise haemodynamic effects caused by each type of plaque. Computational fluid dynamics was performed to simulate realistic physiological conditions that reveal the in vivo cardiac haemodynamics. Velocity, wall shear stress (WSS) and pressure gradient (PSG) in the left coronary artery were calculated and compared in all plaque configurations during cardiac cycles.
  
  
  RESULTS
  Our results showed that the highest velocity and PSG were found in the type of plaque configuration which involved all of the three left coronary branches. Plaques located in the left circumflex branch resulted in highly significant changes of the velocity, WSS and PSG (p<0.001) when compared to the other types of plaque configurations.
  
  
  CONCLUSIONS
  Our analysis provides an insight into the distribution of plaque at the left bifurcation, and corresponding haemodynamic effects, thus, improving our understanding of atherosclerosis.
authors.affiliation: Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, Perth, Western Australia 6845, Australia.
authors.forename: Thanapong
authors.initials: T
authors.lastname: Chaichana
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Sun
authors.forename: James
authors.initials: J
authors.lastname: Jewkes
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*