title: Association of CYP11B2 polymorphisms with susceptibility to primary aldosteronism: a meta-analysis.
abstract: The association of CYP11B2 gene polymorphisms with the risk of primary aldosteronism (PA) was controversial in previous studies. Here we selected two commonly studied CYP11B2 alleles: T-344C, A2718G to explore their associations with PA risk by meta-analyses of published case-control studies. Six electronic databases were searched for relevant studies up to November 2012. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random or fixed effects model. Seven studies (621 cases and 1027 controls) on T-344C polymorphism, three studies (327 cases and 336 controls) on A2718G polymorphism were finally included. Then significant association was observed between T-344C polymorphism and idiopathic hyperaldosteronism (IHA) under three genetic models (CC vs. TT, OR=0.544, 95% CI=0.324~0.914; CT vs. TT, OR=0.554, 95% CI=0.406~0.757; CC+CT vs. TT, OR=0.542, 95% CI=0.402~0.731). But patients with aldosterone-producing adenoma had no significant association with T-344C polymorphism under all genetic models except CT vs. TT model. Concerning A2718G polymorphism, a decreased PA risk was observed only under GG+GA vs AA model. But this association disappeared after removing the studies not in Hardy-Weinberg equilibrium. The evidence accumulated suggested that -344C allele may be associated with decreased risk of IHA and there was still no enough evidence to indicate the association of A2718G polymorphism with PA risk.
authors.affiliation: Department of Endocrinology and Metabolism, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.
authors.forename: Minyue
authors.initials: M
authors.lastname: Jia
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Song
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Pang
authors.forename: Wanlan
authors.initials: W
authors.lastname: Ye
authors.forename: Wenying
authors.initials: W
authors.lastname: Miao
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
mesh_terms: D016022:Case-Control Studies; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D056726:Genetic Association Studies / Q000706:statistics & numerical data; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D006929:Hyperaldosteronism / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D019405:Cytochrome P-450 CYP11B2