title: Lipoprotein metabolism in nonalcoholic fatty liver disease.
abstract: Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists between NAFLD and dyslipidemia, a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins. Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins; they not only play an extracellular role in lipid transport between vital organs through circulation, but also play an important intracellular role in hepatic lipoprotein assembly and secretion. The liver functions as the central hub for lipoprotein metabolism, as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis, potential diagnosis, and treatment of NAFLD.
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA;
authors.forename: Zhenghui Gordon
authors.initials: ZG
authors.lastname: Jiang
authors.forename: Simon C
authors.initials: SC
authors.lastname: Robson
authors.forename: Zemin
authors.initials: Z
authors.lastname: Yao
keywords: apolipoprotein; hepatic steatosis; lipoprotein metabolism; nonalcoholic fatty liver disease (NAFLD); nonalcoholic steatohepatitis; very low density lipoprotein
references.citation: Mol Biol Rep. 2012 Jul;39(7):7381-8
references.pmid: 22350157
references.citation: Gut. 2011 Aug;60(8):1152-8
references.pmid: 21303916
references.citation: Science. 1981 May 8;212(4495):628-35
references.pmid: 6261329
references.citation: J Lipid Res. 2010 Jan;51(1):150-61
references.pmid: 19622837
references.citation: J Clin Invest. 1986 Nov;78(5):1287-95
references.pmid: 3095375
references.citation: Curr Opin Lipidol. 2010 Jun;21(3):229-38
references.pmid: 20480549
references.citation: Hepatology. 2002 Apr;35(4):898-904
references.pmid: 11915037
references.citation: Ann Hepatol. 2011 Apr-Jun;10(2):155-64
references.pmid: 21502677
references.citation: J Biol Chem. 2007 Jul 6;282(27):19453-62
references.pmid: 17500069
references.citation: Lancet. 2010 May 8;375(9726):1634-9
references.pmid: 20452521
references.citation: Proc Natl Acad Sci U S A. 1993 May 15;90(10):4562-6
references.pmid: 8099442
references.citation: EMBO J. 1986 Dec 20;5(13):3495-507
references.pmid: 3030729
references.citation: J Lipid Res. 2004 Jun;45(6):1122-31
references.pmid: 14993246
references.citation: FEBS J. 2011 Sep;278(17):3119-29
references.pmid: 21740524
references.citation: Expert Opin Ther Targets. 2007 Feb;11(2):181-9
references.pmid: 17227233
references.citation: Arterioscler Thromb Vasc Biol. 2012 May;32(5):1073-8
references.pmid: 22517365
references.citation: Gastroenterology. 2011 Jan;140(1):124-31
references.pmid: 20858492
references.citation: Mayo Clin Proc. 1980 Jul;55(7):434-8
references.pmid: 7382552
references.citation: Hepatology. 1999 Dec;30(6):1356-62
references.pmid: 10573511
references.citation: FEBS J. 2009 Oct;276(20):5720-8
references.pmid: 19754875
references.citation: Nature. 1986 Oct 23-29;323(6090):734-8
references.pmid: 3773997
references.citation: J Clin Invest. 1995 Dec;96(6):2601-5
references.pmid: 8675624
references.citation: J Clin Invest. 2008 Jan;118(1):316-32
references.pmid: 18060040
references.citation: Biochem Biophys Res Commun. 2002 Aug 2;295(5):1156-9
references.pmid: 12135615
references.citation: Science. 1992 Nov 6;258(5084):999-1001
references.pmid: 1439810
references.citation: Gut. 2011 Jul;60(7):985-91
references.pmid: 21339203
references.citation: Orphanet J Rare Dis. 2008 Jul 08;3:19
references.pmid: 18611256
references.citation: Science. 1981 Dec 11;214(4526):1239-41
references.pmid: 6795720
references.citation: Clin Chem Lab Med. 2004;42(12):1355-63
references.pmid: 15576296
references.citation: Hepatology. 2011 Feb;53(2):467-74
references.pmid: 21274868
references.citation: Curr Opin Lipidol. 1999 Jun;10(3):207-17
references.pmid: 10431657
references.citation: Clin Biochem. 2007 Nov;40(16-17):1219-24
references.pmid: 17825806
references.citation: J Lipid Res. 2010 Apr;51(4):729-42
references.pmid: 20215580
references.citation: Mol Endocrinol. 2003 Jun;17(6):985-93
references.pmid: 12690094
references.citation: Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1979-84
references.pmid: 16002743
references.citation: N Engl J Med. 2002 Apr 18;346(16):1221-31
references.pmid: 11961152
references.citation: J Biol Chem. 2001 Aug 17;276(33):31466-73
references.pmid: 11427523
references.citation: Science. 1995 Jul 28;269(5223):543-6
references.pmid: 7624777
references.citation: Gastroenterology. 2006 May;130(6):1661-9
references.pmid: 16697730
references.citation: J Lipid Res. 1995 May;36(5):1073-81
references.pmid: 7658155
references.citation: Cell Mol Life Sci. 2005 Jun;62(12):1372-8
references.pmid: 15818469
references.citation: Semin Liver Dis. 2008 Nov;28(4):380-5
references.pmid: 18956294
references.citation: Science. 1988 Apr 29;240(4852):622-30
references.pmid: 3283935
references.citation: J Hepatol. 2009 Jan;50(1):204-10
references.pmid: 19014878
references.citation: Gastroenterology. 2008 Feb;134(2):424-31
references.pmid: 18242210
references.citation: Atherosclerosis. 2007 Dec;195(2):e19-27
references.pmid: 17570373
references.citation: Clin Chem. 2004 Oct;50(10):1725-32
references.pmid: 15308601
references.citation: N Engl J Med. 2006 Nov 30;355(22):2297-307
references.pmid: 17135584
references.citation: Diabetes. 1982 Mar;31(3):217-25
references.pmid: 7152129
references.citation: J Lipid Res. 2003 Jan;44(1):22-32
references.pmid: 12518019
references.citation: J Lipid Res. 2003 May;44(5):878-83
references.pmid: 12639976
references.citation: Science. 2001 Oct 5;294(5540):169-73
references.pmid: 11588264
references.citation: Structure. 2012 May 9;20(5):767-79
references.pmid: 22579246
references.citation: J Biol Chem. 2011 Nov 4;286(44):38570-38582
references.pmid: 21914797
references.citation: Hepatology. 2004 Dec;40(6):1387-95
references.pmid: 15565570
references.citation: Am J Cardiol. 2007 Feb 19;99(4A):96B-104B
references.pmid: 17307062
references.citation: JAMA. 1987 Apr 24;257(16):2176-80
references.pmid: 3560398
references.citation: Curr Opin Lipidol. 1995 Apr;6(2):97-103
references.pmid: 7773575
references.citation: Annu Rev Physiol. 2006;68:159-91
references.pmid: 16460270
references.citation: J Mol Biol. 1999 Jan 8;285(1):391-408
references.pmid: 9878414
references.citation: Nat Clin Pract Cardiovasc Med. 2008 Nov;5(11):730-7
references.pmid: 18779834
references.citation: Cell Cycle. 2008 Oct;7(20):3162-70
references.pmid: 18927507
references.citation: J Clin Invest. 2006 Mar;116(3):581-9
references.pmid: 16511590
references.citation: J Mol Biol. 2008 Nov 28;383(5):1181-94
references.pmid: 18804479
references.citation: N Engl J Med. 1969 Mar 27;280(13):705-8
references.pmid: 4885586
references.citation: J Biol Chem. 2011 Aug 5;286(31):27769-80
references.pmid: 21676879
references.citation: Trends Biochem Sci. 2006 Oct;31(10):572-80
references.pmid: 16908160
references.citation: J Hepatol. 2006 Apr;44(4):732-41
references.pmid: 16466828
references.citation: J Biol Chem. 2002 May 17;277(20):17377-80
references.pmid: 12006608
references.citation: Cell. 1998 May 29;93(5):693-704
references.pmid: 9630215
references.citation: J Biol Chem. 2008 Apr 25;283(17):11164-75
references.pmid: 18218626
references.citation: Science. 1987 Oct 16;238(4825):363-6
references.pmid: 3659919
references.citation: Diabetologia. 2000 Aug;43(8):995-9
references.pmid: 10990076
references.citation: Metabolism. 2007 Jan;56(1):68-76
references.pmid: 17161228
references.citation: J Hepatol. 2009 Sep;51(3):433-45
references.pmid: 19604596
references.citation: N Engl J Med. 2007 Jan 11;356(2):148-56
references.pmid: 17215532
references.citation: Circulation. 2007 Jan 30;115(4):518-33
references.pmid: 17261671
references.citation: N Engl J Med. 1985 Aug 8;313(6):367-70
references.pmid: 3892299
references.citation: Curr Opin Lipidol. 2008 Jun;19(3):221-8
references.pmid: 18460911
references.citation: Arch Med Res. 2005 May-Jun;36(3):232-40
references.pmid: 15925013
references.citation: Gastroenterology. 2008 Feb;134(2):556-67
references.pmid: 18242221
references.citation: N Engl J Med. 2010 May 6;362(18):1675-85
references.pmid: 20427778
references.citation: J Hepatol. 2001 Dec;35(6):816-22
references.pmid: 11738112
references.citation: J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:163-72
references.pmid: 21199528
references.citation: J Lipid Res. 2004 May;45(5):941-7
references.pmid: 14967820
references.citation: N Engl J Med. 2010 Mar 25;362(12):1082-9
references.pmid: 20335584
references.citation: Gastroenterology. 2003 Jan;124(1):71-9
references.pmid: 12512031
references.citation: Prog Lipid Res. 2011 Jan;50(1):62-74
references.pmid: 20854843
references.citation: Biochemistry. 1998 Jul 14;37(28):10203-10
references.pmid: 9665727
references.citation: Curr Opin Lipidol. 2010 Oct;21(5):409-15
references.pmid: 20683326
references.citation: PPAR Res. 2010;2010:
references.pmid: 20847941
references.citation: Gastroenterology. 2005 Jul;129(1):113-21
references.pmid: 16012941
references.citation: J Lipid Res. 2007 Jul;48(7):1445-50
references.pmid: 17460328
references.citation: Cell. 1987 Sep 11;50(6):831-40
references.pmid: 3621347
references.citation: Curr Opin Lipidol. 2010 Aug;21(4):319-23
references.pmid: 20508521
references.citation: J Biol Chem. 2002 Apr 19;277(16):14135-45
references.pmid: 11839763
references.citation: Clin Gastroenterol Hepatol. 2008 Dec;6(12):1396-402
references.pmid: 18986848
references.citation: Clin Chem. 2005 Feb;51(2):351-9
references.pmid: 15528295
references.citation: J Biol Chem. 1998 Oct 9;273(41):26388-93
references.pmid: 9756870
references.citation: J Biol Chem. 2000 Oct 20;275(42):32807-15
references.pmid: 10893242
references.citation: Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E567-84
references.pmid: 21791620
references.citation: Mol Cell Biochem. 2009 Jun;326(1-2):105-19
references.pmid: 19130182
references.citation: J Lipid Res. 1982 Aug;23(6):911-4
references.pmid: 7130859
references.citation: Dig Dis Sci. 2008 Dec;53(12):3218-24
references.pmid: 18465245
references.citation: Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E271-88
references.pmid: 19318514
references.citation: Arterioscler Thromb Vasc Biol. 1996 Aug;16(8):941-7
references.pmid: 8696957
references.citation: Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1519-28
references.pmid: 20631352
references.citation: Atherosclerosis. 2009 Jun;204(2):538-43
references.pmid: 19013572
references.citation: Dig Dis Sci. 2007 Dec;52(12):3399-403
references.pmid: 17431774
references.citation: Hepatology. 2011 Nov;54(5):1650-60
references.pmid: 21793029
references.citation: Curr Opin Lipidol. 2012 Feb;23(1):35-42
references.pmid: 22123668
references.citation: Hepatology. 2009 Mar;49(3):791-801
references.pmid: 19105205
references.citation: J Gastroenterol Hepatol. 2004 Jun;19(6):694-8
references.pmid: 15151626
references.citation: Trends Endocrinol Metab. 2011 Sep;22(9):353-63
references.pmid: 21616678
references.citation: J Biol Chem. 2003 Apr 11;278(15):13442-52
references.pmid: 12551903
references.citation: Diabetes. 2005 Jun;54(6):1676-83
references.pmid: 15919788
references.citation: Biochim Biophys Acta. 2000 Jan 3;1483(1):15-36
references.pmid: 10601693
references.citation: J Clin Invest. 1997 Dec 1;100(11):2915-22
references.pmid: 9389759
references.citation: J Lipid Res. 1999 Jun;40(6):1036-44
references.pmid: 10357835
references.citation: Biochemistry. 1991 May 7;30(18):4406-12
references.pmid: 2021632
references.citation: Hepatology. 2007 May;45(5):1097-107
references.pmid: 17464986
references.citation: J Clin Endocrinol Metab. 2011 Nov;96(11):3313-25
references.pmid: 21865368
references.citation: Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):513-9
references.pmid: 21183731
references.citation: Gastroenterology. 2005 Jun;128(7):1898-906
references.pmid: 15940625
references.citation: Am Heart J. 1987 Feb;113(2 Pt 2):433-40
references.pmid: 3544759
references.citation: Gut. 2005 Jul;54(7):987-93
references.pmid: 15951547
references.citation: Am J Gastroenterol. 2007 Dec;102(12):2708-15
references.pmid: 17894848
references.citation: Gastroenterology. 2010 Jul;139(1):149-53
references.pmid: 20303351
references.citation: Diabetologia. 2002 Sep;45(9):1201-10
references.pmid: 12242452
references.citation: Am J Clin Nutr. 2010 Jan;91(1):262S-266S
references.pmid: 19923366
references.citation: J Biol Chem. 2007 Aug 17;282(33):24270-83
references.pmid: 17588943
references.citation: Dig Dis Sci. 2008 May;53(5):1352-7
references.pmid: 17939039
references.citation: J Clin Endocrinol Metab. 2010 May;95(5):2467-75
references.pmid: 20332251
references.citation: Hepatology. 2005 Jul;42(1):44-52
references.pmid: 15895401
references.citation: Diabetologia. 2006 Apr;49(4):755-65
references.pmid: 16463046
references.citation: Biochemistry. 1993 Oct 5;32(39):10444-50
references.pmid: 8399189
references.citation: Fish Physiol Biochem. 2011 Sep;37(3):613-8
references.pmid: 21184175
references.citation: Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):471-3
references.pmid: 21325666
references.citation: J Clin Invest. 2005 May;115(5):1343-51
references.pmid: 15864352
references.citation: J Biol Chem. 1976 Apr 25;251(8):2395-8
references.pmid: 177413
references.citation: Arterioscler Thromb Vasc Biol. 1995 May;15(5):593-600
references.pmid: 7749873
references.citation: J Hepatol. 2011 May;54(5):1055-62
references.pmid: 21145846
references.citation: J Lipid Res. 2010 Jun;51(6):1524-34
references.pmid: 20097930
references.citation: Gastroenterology. 1989 Sep;97(3):766-70
references.pmid: 2753336
references.citation: J Biol Chem. 2008 Jun 20;283(25):17416-27
references.pmid: 18408013
references.citation: Endocr Pract. 2010 Mar-Apr;16(2):324-33
references.pmid: 20061299
references.citation: Diabetes Care. 2006 Jun;29(6):1325-30
references.pmid: 16732016
references.citation: Hepatology. 2010 Jan;51(1):111-20
references.pmid: 19885878
references.citation: Genes Dev. 1998 Oct 15;12(20):3182-94
references.pmid: 9784493