title: Human infections and detection of Plasmodium knowlesi.
abstract: Plasmodium knowlesi is a malaria parasite that is found in nature in long-tailed and pig-tailed macaques. Naturally acquired human infections were thought to be extremely rare until a large focus of human infections was reported in 2004 in Sarawak, Malaysian Borneo. Human infections have since been described throughout Southeast Asia, and P. knowlesi is now recognized as the fifth species of Plasmodium causing malaria in humans. The molecular, entomological, and epidemiological data indicate that human infections with P. knowlesi are not newly emergent and that knowlesi malaria is primarily a zoonosis. Human infections were undiagnosed until molecular detection methods that could distinguish P. knowlesi from the morphologically similar human malaria parasite P. malariae became available. P. knowlesi infections cause a spectrum of disease and are potentially fatal, but if detected early enough, infections in humans are readily treatable. In this review on knowlesi malaria, we describe the early studies on P. knowlesi and focus on the epidemiology, diagnosis, clinical aspects, and treatment of knowlesi malaria. We also discuss the gaps in our knowledge and the challenges that lie ahead in studying the epidemiology and pathogenesis of knowlesi malaria and in the prevention and control of this zoonotic infection.
authors.affiliation: Malaria Research Centre, Universiti Malaysia Sarawak, Kuching, Sarawak, Malaysia. bskhaira55@gmail.com
authors.forename: Balbir
authors.initials: B
authors.lastname: Singh
authors.forename: Cyrus
authors.initials: C
authors.lastname: Daneshvar
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D001210:Asia, Southeastern / Q000453:epidemiology; D003140:Communicable Disease Control / Q000379:methods; D004197:Disease Reservoirs; D006801:Humans; D008251:Macaca / Q000469:parasitology; D008288:Malaria / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D016790:Plasmodium knowlesi / Q000302:isolation & purification*; D015047:Zoonoses / Q000453:epidemiology*
chemical_list: D000962:Antimalarials
references.citation: Int J Parasitol. 2009 Dec;39(14):1533-7
references.pmid: 19703460
references.citation: Science. 2005 May 13;308(5724):1034-6
references.pmid: 15890885
references.citation: PLoS Pathog. 2010 Feb 12;6(2):e1000765
references.pmid: 20169187
references.citation: Trans R Soc Trop Med Hyg. 1989 Jul-Aug;83(4):484
references.pmid: 2617597
references.citation: PLoS One. 2012;7(2):e31848
references.pmid: 22363751
references.citation: Malar J. 2012 Jun 22;11:213
references.pmid: 22727041
references.citation: Emerg Infect Dis. 2004 Dec;10(12):2211-3
references.pmid: 15663864
references.citation: Malar J. 2008 Mar 31;7:52
references.pmid: 18377652
references.citation: Interdiscip Perspect Infect Dis. 2009;2009:415953
references.pmid: 19547702
references.citation: Travel Med Infect Dis. 2011 May;9(3):144-8
references.pmid: 21481643
references.citation: J Trop Med Hyg. 1958 Mar;61(3):57-61
references.pmid: 13514844
references.citation: Intensive Care Med. 1991;17(8):449-54
references.pmid: 1797887
references.citation: Ind Med Gaz. 1932 Jun;67(6):301-320
references.pmid: 29010910
references.citation: J Infect Dis. 2009 Apr 15;199(8):1143-50
references.pmid: 19284284
references.citation: Chest. 1995 Sep;108(3):746-9
references.pmid: 7656627
references.citation: Lancet. 2004 Mar 27;363(9414):1017-24
references.pmid: 15051281
references.citation: Malar J. 2010 Aug 19;9:238
references.pmid: 20723228
references.citation: Malar J. 2011 Jul 20;10:197
references.pmid: 21774805
references.citation: Science. 1965 Aug 20;149(3686):865
references.pmid: 14332847
references.citation: Emerg Infect Dis. 2008 May;14(5):811-3
references.pmid: 18439369
references.citation: Am J Trop Med Hyg. 1970 May;19(3):383-93
references.pmid: 4392806
references.citation: Trends Parasitol. 2008 Sep;24(9):406-10
references.pmid: 18678527
references.citation: Med J Malaysia. 2010 Mar;65(1):63-5
references.pmid: 21265252
references.citation: Emerg Infect Dis. 2008 Sep;14(9):1434-6
references.pmid: 18760013
references.citation: Am J Trop Med Hyg. 2009 Jun;80(6):927-8
references.pmid: 19478250
references.citation: Emerg Infect Dis. 2008 Nov;14(11):1750-2
references.pmid: 18976561
references.citation: PLoS One. 2009 Oct 07;4(10):e7369
references.pmid: 19809502
references.citation: Trans R Soc Trop Med Hyg. 1949 Jul;43(1):33-48
references.pmid: 18139104
references.citation: PLoS Pathog. 2011 Apr;7(4):e1002015
references.pmid: 21490952
references.citation: Emerg Infect Dis. 2011 Jul;17(7):1232-9
references.pmid: 21762577
references.citation: Science. 1960 Jun 17;131(3416):1812-3
references.pmid: 13821129
references.citation: Med Vet Entomol. 2005 Jun;19(2):158-99
references.pmid: 15958025
references.citation: N Engl J Med. 1983 Jul 14;309(2):61-6
references.pmid: 6343877
references.citation: N Engl J Med. 1982 Feb 11;306(6):313-9
references.pmid: 7033788
references.citation: Intensive Care Med. 2000 Feb;26(2):195-201
references.pmid: 10784308
references.citation: Emerg Infect Dis. 2011 Oct;17(10):1799-806
references.pmid: 22000348
references.citation: Clin Infect Dis. 2013 Feb;56(3):383-97
references.pmid: 23087389
references.citation: PLoS One. 2011;6(6):e20541
references.pmid: 21687657
references.citation: Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1980-5
references.pmid: 15684081
references.citation: Indian J Med Res. 1979 Dec;70 Suppl:91-4
references.pmid: 121297
references.citation: Science. 2003 Apr 11;300(5617):318-21
references.pmid: 12690197
references.citation: Mol Biol Evol. 2005 Aug;22(8):1686-93
references.pmid: 15858201
references.citation: Malar J. 2009 Jan 16;8:15
references.pmid: 19146706
references.citation: Malar J. 2012 Oct 30;11:363
references.pmid: 23110615
references.citation: Curr Hematol Rep. 2005 Mar;4(2):145-8
references.pmid: 15720964
references.citation: Malar J. 2012 Aug 20;11:284
references.pmid: 22905799
references.citation: Br Med J. 1935 Oct 12;2(3901):662-6
references.pmid: 20779410
references.citation: Ann Trop Med Parasitol. 1983 Jun;77(3):231-7
references.pmid: 6625724
references.citation: Trans R Soc Trop Med Hyg. 1970;64(6):850-6
references.pmid: 4993013
references.citation: Malar J. 2010 Jul 27;9:219
references.pmid: 20663184
references.citation: Emerg Infect Dis. 2011 May;17(5):814-20
references.pmid: 21529389
references.citation: Evolution. 2003 Jun;57(6):1419-35
references.pmid: 12894949
references.citation: Emerg Infect Dis. 2011 Jul;17(7):1314-5
references.pmid: 21762601
references.citation: Trans R Soc Trop Med Hyg. 1996 Sep-Oct;90(5):519-21
references.pmid: 8944260
references.citation: Parasit Vectors. 2008 Aug 19;1(1):26
references.pmid: 18710577
references.citation: Scand J Infect Dis. 1989;21(4):434-41
references.pmid: 2587946
references.citation: Am J Trop Med Hyg. 1968 May;17(3):355-8
references.pmid: 4385130
references.citation: Am J Trop Med Hyg. 2011 Apr;84(4):535-8
references.pmid: 21460005
references.citation: Indian J Malariol. 1954 Sep;8(3):187-95
references.pmid: 14353521
references.citation: Am J Trop Med Hyg. 1996 Apr;54(4):325-31
references.pmid: 8615441
references.citation: J Parasitol. 1971 Oct;57(5):961-6
references.pmid: 5002525
references.citation: Mol Phylogenet Evol. 2007 Mar;42(3):807-16
references.pmid: 17208017
references.citation: Trans R Soc Trop Med Hyg. 2000 Apr;94 Suppl 1:S1-90
references.pmid: 11103309
references.citation: Vector Borne Zoonotic Dis. 2011 Feb;11(2):131-5
references.pmid: 20586605
references.citation: Malar J. 2010 Jan 11;9:10
references.pmid: 20064229
references.citation: Clin Infect Dis. 2009 Sep 15;49(6):852-60
references.pmid: 19635025
references.citation: Am J Trop Med Hyg. 2001 Nov;65(5):614-22
references.pmid: 11716124
references.citation: J Clin Microbiol. 2010 Oct;48(10):3735-7
references.pmid: 20702666
references.citation: J Clin Microbiol. 2009 Dec;47(12):4173-5
references.pmid: 19812279
references.citation: Emerg Infect Dis. 2008 May;14(5):814-6
references.pmid: 18439370
references.citation: Emerg Infect Dis. 2009 Sep;15(9):1478-80
references.pmid: 19788819
references.citation: Clin Infect Dis. 2008 Jan 15;46(2):172-3
references.pmid: 18171246
references.citation: Emerg Infect Dis. 2011 Oct;17(10):1900-2
references.pmid: 22000366
references.citation: Trans R Soc Trop Med Hyg. 2006 Nov;100(11):1087-8
references.pmid: 16725166
references.citation: Int J Parasitol. 2009 Aug;39(10):1125-8
references.pmid: 19358848
references.citation: Am J Trop Med Hyg. 2009 Sep;81(3):516-8
references.pmid: 19706924
references.citation: Int J Parasitol. 1997 Dec;27(12):1575-7
references.pmid: 9467744
references.citation: Malar J. 2009 Oct 30;8:249
references.pmid: 19878553
references.citation: Trans R Soc Trop Med Hyg. 1971;65(6):839-40
references.pmid: 5003320
references.citation: Nature. 1961 Sep 9;191:1117-8
references.pmid: 13758508
references.citation: Bull World Health Organ. 1956;15(3-5):651-71
references.pmid: 13404442
references.citation: Methods Mol Med. 2002;72:189-203
references.pmid: 12125116
references.citation: Clin Infect Dis. 2008 Jan 15;46(2):165-71
references.pmid: 18171245
references.citation: Malar J. 2009 Apr 21;8:73
references.pmid: 19383118
references.citation: J Parasitol. 1967 Aug;53(4):841-4
references.pmid: 6035726
references.citation: Eur J Clin Microbiol Infect Dis. 2011 Apr;30(4):597-601
references.pmid: 21161559
references.citation: Emerg Infect Dis. 2010 Jun;16(6):1033-4
references.pmid: 20507769
references.citation: J Parasitol Res. 2011;2011:104284
references.pmid: 22013506
references.citation: Malar J. 2012 Feb 03;11:33
references.pmid: 22305466
references.citation: J Clin Microbiol. 2010 Jul;48(7):2509-14
references.pmid: 20444968
references.citation: Am J Trop Med Hyg. 2004 Jan;70(1):8-14
references.pmid: 14971691
references.citation: Zhongguo Yao Li Xue Bao. 1999 Aug;20(8):755-8
references.pmid: 10678113
references.citation: Trans R Soc Trop Med Hyg. 1952 Nov;46(6):639-49
references.pmid: 13005681
references.citation: Malar J. 2012 Feb 08;11:36
references.pmid: 22313518
references.citation: Parasitol Int. 2009 Sep;58(3):300-2
references.pmid: 19527797
references.citation: Emerg Infect Dis. 2011 Jul;17(7):1248-55
references.pmid: 21762579
references.citation: Mol Biol Evol. 2008 Feb;25(2):468-74
references.pmid: 18093996
references.citation: Med J Malaysia. 2010 Sep;65(3):166-72
references.pmid: 21939162
references.citation: Exp Parasitol. 1976 Aug;40(1):13-24
references.pmid: 820562
references.citation: J Clin Microbiol. 2012 Jul;50(7):2523-4
references.pmid: 22573596
references.citation: Am J Trop Med Hyg. 1999 Apr;60(4):687-92
references.pmid: 10348249
references.citation: Emerg Infect Dis. 2010 Sep;16(9):1476-8
references.pmid: 20735938
references.citation: Lancet. 1985 Apr 6;1(8432):776-8
references.pmid: 2858665
references.citation: Emerg Infect Dis. 2010 Apr;16(4):672-4
references.pmid: 20350383
references.citation: Mol Biochem Parasitol. 1993 Oct;61(2):315-20
references.pmid: 8264734
references.citation: Malar J. 2010 Nov 30;9:344
references.pmid: 21114872
references.citation: Ind Med Gaz. 1932 May;67(5):246-249
references.pmid: 29011028
references.citation: Ind Med Gaz. 1936 Apr;71(4):187-189
references.pmid: 29013027
references.citation: Am J Trop Med Hyg. 1961 Sep;10:679-88
references.pmid: 13748031
references.citation: Science. 1961 Jul 28;134(3474):279-80
references.pmid: 13784726
references.citation: Bull World Health Organ. 2008 Feb;86(2):82
references.pmid: 18297155
references.citation: Indian J Malariol. 1953 Dec;7(4):371-6
references.pmid: 13183653
references.citation: Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006 Feb 28;24(1):70-1
references.pmid: 16866152