title: Influence of zinc hydroaspartate on the anti-inflammatory and gastric activity of ketoprofen in rats.
abstract: BACKGROUND
  The study's aim was to evaluate the anti-inflammatory effect and influence on gastric mucosa after the combined administration of ketoprofen and zinc hydroaspartate (ZHA, 60 mg/kg).
  
  
  METHODS
  Antiedematous activity was determined according toWinter et al., analgesic activity according to the Randall and Selitto test, the influence on gastric mucosa in accordance to Komatsu.
  
  
  RESULTS
  Single and subchronic administration of ZHA and single ketoprofen po caused a significant reduction of the rat hind paw edema in comparison to the control groups. ZHA alone administrated ip four times was active after the 1st, 2nd and 3rd h from the carrageenan injection.
  
  
  CONCLUSIONS
  ZHA enhanced the anti-inflammatory effect of ketoprofen.
authors.affiliation: Department of Radioligands, Jagiellonian University, Medical College, Faculty of Pharmacy, Medyczna 9, PL 30-688 Kraków, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Gaweł
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Librowski
authors.forename: Anna
authors.initials: A
authors.lastname: Lipkowska
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001224:Aspartic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D002351:Carrageenan; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology; D007274:Injections, Intraperitoneal; D007660:Ketoprofen / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology*; D017967:Zinc Compounds / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009942:Organometallic Compounds; D017967:Zinc Compounds; C106152:zinc-bis(hydrogenaspartate); D001224:Aspartic Acid; D002351:Carrageenan; D007660:Ketoprofen; D015032:Zinc