title: Serum IgG levels in IV immunoglobulin treated chronic inflammatory demyelinating polyneuropathy.
abstract: OBJECTIVE
  To determine the variability of serum IgG in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).
  
  
  METHODS
  All 25 CIDP patients had active but stable disease and were treated with individually optimised fixed dose IVIg regimens. IgG was measured by turbidimetry and variability was defined as coefficient of variation (CV).
  
  
  RESULTS
  The intra-patient variability of the pre-treatment IgG levels, post-treatment levels and increase in serum IgG shortly after IVIg (ΔIgG) was low (mean CV=3%, 4%, 10%). The inter-patient variability between patients treated with the same dose and interval was low in pre-treatment, post-treatment and ΔIgG level (mean CV=13%, 11%, 20%). The ΔIgG levels were associated with IVIg dosage (rs=0.78, p<0.001).
  
  
  CONCLUSIONS
  Clinically stable CIDP patients show a steady-state in serum IgG after serial IVIg infusions. The low intra- and inter-patient variability in IgG may indicate that constant levels are required to reach this stability.
authors.affiliation: Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Room Ee-2230, PO Box 2040, Rotterdam 3000 CA, The Netherlands. k.kuitwaard@erasmusmc.nl
authors.forename: Krista
authors.initials: K
authors.lastname: Kuitwaard
authors.forename: Pieter A
authors.initials: PA
authors.lastname: van Doorn
authors.forename: Marinus
authors.initials: M
authors.lastname: Vermeulen
authors.forename: Leonard H
authors.initials: LH
authors.lastname: van den Berg
authors.forename: Esther
authors.initials: E
authors.lastname: Brusse
authors.forename: Anneke J
authors.initials: AJ
authors.lastname: van der Kooi
authors.forename: W-Ludo
authors.initials: WL
authors.lastname: van der Pol
authors.forename: Ivo N
authors.initials: IN
authors.lastname: van Schaik
authors.forename: Nicolette
authors.initials: N
authors.lastname: Notermans
authors.forename: Anne P
authors.initials: AP
authors.lastname: Tio-Gillen
authors.forename: Wouter
authors.initials: W
authors.lastname: van Rijs
authors.forename: Teun
authors.initials: T
authors.lastname: van Gelder
authors.forename: Bart C
authors.initials: BC
authors.lastname: Jacobs
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage* / Q000627:therapeutic use*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000097:blood* / Q000628:therapy*
chemical_list: D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous
keywords: CLINICAL NEUROLOGY; NEUROIMMUNOLOGY; NEUROMUSCULAR; PERIPHERAL NEUROPATHOLOGY; PHARMACOKINETICS