title: Prognostic factors and risk stratification in early mycosis fungoides.
abstract: Available demographic, clinical, histologic, immunohistochemical and laboratory findings, including serum cytokine/cytokine receptor levels, obtained at initial evaluation in a cohort of 33 patients with mycosis fungoides (MF) at stages I-IIA who had subsequent progression of disease were compared against 70 stage-matched cases of MF without observed progression. Significant factors that correlated with both disease progression and overall survival were: (1) presence of large Pautrier microabscesses (10 or more atypical lymphocytes), (2) presence of atypical lymphocytes with hyperchromatic or vesicular nuclei in the dermal infiltrate, (3) less than 20% CD8 + cells in the dermal infiltrate and (4) above normal (> 122 U/mL) serum immunoglobulin E (IgE) level. Combination of these factors was used to construct prognostic groupings which, if validated, might be useful to identify patients with clinically early MF at highest risk for disease progression and poor outcome.
authors.affiliation: Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutes , Baltimore, MD , USA.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Vonderheid
authors.forename: Igor
authors.initials: I
authors.lastname: Pavlov
authors.forename: Julio C
authors.initials: JC
authors.lastname: Delgado
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Martins
authors.forename: Gladys H
authors.initials: GH
authors.lastname: Telang
authors.forename: Allan D
authors.initials: AD
authors.lastname: Hess
authors.forename: Marshall E
authors.initials: ME
authors.lastname: Kadin
mesh_terms: D015415:Biomarkers; D020405:Dermis / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood / Q000378:metabolism; D008214:Lymphocytes / Q000473:pathology; D009182:Mycosis Fungoides / Q000378:metabolism / Q000401:mortality* / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D012878:Skin Neoplasms / Q000401:mortality* / Q000473:pathology*
chemical_list: D015415:Biomarkers; D017730:Ki-1 Antigen