title: Development of a (11)C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation.
abstract: Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first (11)C-labelled tetrazine and its reaction with trans-cyclooctenol.
authors.affiliation: Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. matthias.herth@nru.dk
authors.forename: Matthias M
authors.initials: MM
authors.lastname: Herth
authors.forename: Valdemar L
authors.initials: VL
authors.lastname: Andersen
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Lehel
authors.forename: Jacob
authors.initials: J
authors.lastname: Madsen
authors.forename: Gitte M
authors.initials: GM
authors.lastname: Knudsen
authors.forename: Jesper L
authors.initials: JL
authors.lastname: Kristensen
mesh_terms: D000906:Antibodies / Q000737:chemistry; D002250:Carbon Radioisotopes / Q000737:chemistry; D057930:Click Chemistry; D003287:Contrast Media / Q000737:chemistry; D034242:Cyclooctanes / Q000737:chemistry*; D007536:Isomerism; D053758:Nanoparticles / Q000737:chemistry; D049268:Positron-Emission Tomography; D013777:Tetrazoles / Q000737:chemistry*
chemical_list: D000906:Antibodies; D002250:Carbon Radioisotopes; D003287:Contrast Media; D034242:Cyclooctanes; D013777:Tetrazoles