title: New RNA purine building blocks, 4'-selenopurine nucleosides: first synthesis and unusual mixture of sugar puckerings.
abstract: Writer's blocks: The first synthesis of RNA purine building blocks, 4'-selenoadenosine and 4'-selenoguanosine was achieved from D-ribose by regioisomeric rearrangement, which was confirmed by X-ray crystallography. 4'-Selenoadenosine exists in an unusual mixture of north and south conformers in the solid state.
authors.affiliation: Department of Bioinspired Science and College of Pharmacy, Ewha Womans University, Seoul, Korea.
authors.forename: Jinha
authors.initials: J
authors.lastname: Yu
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyuk Woo
authors.initials: HW
authors.lastname: Lee
authors.forename: Varughese
authors.initials: V
authors.lastname: Alexander
authors.forename: Hee-Chul
authors.initials: HC
authors.lastname: Ahn
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Choi
authors.forename: Jungwon
authors.initials: J
authors.lastname: Choi
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D018360:Crystallography, X-Ray; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry; D012313:RNA / Q000737:chemistry*; D012266:Ribose / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C531224:4'-selenoadenosine; C584885:4'-selenoguanosine; D009705:Nucleosides; D016566:Organoselenium Compounds; D011687:Purines; D006151:Guanosine; D012313:RNA; D012266:Ribose; D000241:Adenosine