title: Oral health and oral quality of life in inactive patients with familial Mediterranean fever without amyloidosis.
abstract: OBJECTIVE
  The aim of this study was to investigate oral and general health-related quality of life (QoL) in patients with familial Mediterranean fever (FMF) disease.
  
  
  METHODS
  In this cross-sectional study, 45 patients with FMF, 50 age- and sex-matched healthy controls (HC), and 50 patients with Behçet's disease (BD) as the disease control group were included. FMF disease activity was evaluated by using the FMF-severity score, as well as with erythrocyte sedimentation rate (ESR), and serum C-reactive protein and fibrinogen levels. Oral health-related QoL and general QoL were evaluated using oral health impact profile-14 (OHIP-14) and Medical Outcomes Short-Form Health Survey Questionnaire 36 (SF-36), respectively.
  
  
  RESULTS
  Only the numbers of extracted teeth (4.13±4.72 vs. 1.55±3.6) and filled teeth (2.33±3.19 vs. 0.66±1.46) were significantly higher in FMF group compared to HC group (p=0.005 and p=0.013, respectively). OHIP-14 score was significantly higher in FMF and BD groups compared to HC group. In FMF patients, OHIP-14 score was positively correlated with the number of extracted teeth (r=0.38, p=0.010), while the number of carious teeth was positively correlated with ESR (r=0.43, p=0.003). When FMF patients were sub-classified according to disease severity, no significant difference was observed with respect to oral health status.
  
  
  CONCLUSIONS
  In patients with FMF, some of the parameters of oral health status were found to be worse compared to HC group. Tooth loss appears to be to be a critical factor contributing to impaired oral QoL. In general, oral health status in FMF patients is better than in BD patients.
authors.affiliation: Ege University, School of Dentistry, Department of Oral Maxillofacial Radiology, Izmir, Turkey. esogur@yahoo.com.
authors.forename: Elif
authors.initials: E
authors.lastname: Sogur
authors.forename: Erinç
authors.initials: E
authors.lastname: Önem
authors.forename: Melike
authors.initials: M
authors.lastname: Kalfa
authors.forename: Hakan
authors.initials: H
authors.lastname: Emmungil
authors.forename: Nagihan
authors.initials: N
authors.lastname: Bostancı
authors.forename: Kenan
authors.initials: K
authors.lastname: Aksu
authors.forename: B Güniz
authors.initials: BG
authors.lastname: Baksı
authors.forename: Gökhan
authors.initials: G
authors.lastname: Keser
authors.forename: Haner
authors.initials: H
authors.lastname: Direskeneli
authors.forename: Gonca
authors.initials: G
authors.lastname: Mumcu
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D003731:Dental Caries / Q000209:etiology / Q000523:psychology / Q000628:therapy; D003793:Dental Restoration, Permanent; D010505:Familial Mediterranean Fever / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009909:Oral Health; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014081:Tooth Extraction
chemical_list: D015415:Biomarkers; D005340:Fibrinogen; D002097:C-Reactive Protein