title: Frequency of multi-dimensional COPD indices and relation with disease activity markers.
abstract: Our aim was to describe the population-based distribution of several COPD multi-dimensional indices and to evaluate their relationship with daily physical activity, co-morbidity, health status and systemic inflammatory biomarkers. From a population-based sample of 3,802 subjects aged 40-80 from the EPI-SCAN study, 382 subjects (10.2%) with a post-bronchodilator FEV1/FVC<0.7 were identified as COPD. Smoking habits, respiratory symptoms, quality of life, co-morbidities, lung function and inflammatory biomarkers were recorded. Health status and daily physical activity were assessed using the EQ-5D and LCADL questionnaires, respectively. The new GOLD grading and the BODE, ADO, DOSE, modified DOSE, e-BODE, BODEx, CPI, SAFE and HRS indices were determined. A notable dispersion in the total scores was observed, although 83-88% of the COPD patients were classified into the mildest level and 1-3% in the most severe. The SAFE index was the best independent determinant of daily physical activity; the SAFE and ADO indices were associated with presence of co-morbidity; and the SAFE and modified DOSE indices were independently related to health status. The systemic biomarkers showed a less consistent relation with several indices. In a population-based sample of COPD patients, the SAFE index reaches the highest relation with physical activity, co-morbidity and health status.
authors.affiliation: Servicio de Neumología, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. fgr01m@gmail.com
authors.forename: Francisco
authors.initials: F
authors.lastname: García-Rio
authors.forename: Joan B
authors.initials: JB
authors.lastname: Soriano
authors.forename: Marc
authors.initials: M
authors.lastname: Miravitlles
authors.forename: Luis
authors.initials: L
authors.lastname: Muñoz
authors.forename: Enric
authors.initials: E
authors.lastname: Duran-Tauleria
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Sánchez
authors.forename: Victor
authors.initials: V
authors.lastname: Sobradillo
authors.forename: Julio
authors.initials: J
authors.lastname: Ancochea
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D015897:Comorbidity; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000145:classification* / Q000503:physiopathology*; D011788:Quality of Life; D012709:Serum Albumin / Q000378:metabolism; D012720:Severity of Illness Index; D013147:Spirometry; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D016207:Cytokines; D009566:Nitrates; D009573:Nitrites; D012709:Serum Albumin; D005340:Fibrinogen; D002097:C-Reactive Protein