title: Postoperative analgesic effects of dexketoprofen, buprenorphine and tramadol in dogs undergoing ovariohysterectomy.
abstract: The objective of this study was to compare the postoperative analgesic effects of dexketoprofen, tramadol, and buprenorphine in dogs undergoing ovariohysterectomy. Seventy-five adult female dogs were randomly assigned to receive an intravenous injection (IV) of 1mg/kg of dexketoprofen (D), 0.02 mg/kg of buprenorphine (B) or 2mg/kg of tramadol (T). Pain assessment was performed during 48 h after ovariohysterectomy using a dynamic interactive visual analogue scale (DIVAS) and Glasgow composite measure pain scale (CMPS-SF). Rescue analgesia was required in 43%, 21%, and 5% of dogs in the B, T, and D groups, respectively, with significant differences between B and D (p=0.010) groups. The DIVAS and CMPS-SF values of the B group were significantly higher than those of the T and D groups. The most common undesirable effect was dysphoria in dexketoprofen group. Tramadol and dexketoprofen provide superior postoperative analgesia compared with buprenorphine in dogs undergoing ovariohysterectomy.
authors.affiliation: Department of Animal Medicine and Surgery, Veterinary School of Córdoba, University of Córdoba, Francisco Santisteban Hospital, Campus de Rabanales, 14014 Córdoba, Spain. v92moroj@uco.es
authors.forename: J
authors.initials: J
authors.lastname: Morgaz
authors.forename: R
authors.initials: R
authors.lastname: Navarrete
authors.forename: P
authors.initials: P
authors.lastname: Muñoz-Rascón
authors.forename: J M
authors.initials: JM
authors.lastname: Domínguez
authors.forename: J A
authors.initials: JA
authors.lastname: Fernández-Sarmiento
authors.forename: R J
authors.initials: RJ
authors.lastname: Gómez-Villamandos
authors.forename: M M
authors.initials: MM
authors.lastname: Granados
mesh_terms: D000698:Analgesia / Q000662:veterinary*; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology*; D004285:Dogs / Q000601:surgery*; D005260:Female; D007044:Hysterectomy / Q000662:veterinary*; D007275:Injections, Intravenous / Q000662:veterinary; D007660:Ketoprofen / Q000494:pharmacology*; D010052:Ovariectomy / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary; D011897:Random Allocation; D018709:Statistics, Nonparametric; D014147:Tramadol / Q000494:pharmacology*
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol; D002047:Buprenorphine; D007660:Ketoprofen