title: Mild acute pancreatitis with vildagliptin use.
abstract: Vildagliptin has not been associated with the development of acute pancreatitis in postmarketing reports except one case report from Sydney, Australia. We present the case report of 42 year old male, diabetic, with no historyof alcohol use, on vildagliptin 50 mg and metformin 500 mg daily since 6 months, who presented with severe abdominal pain radiating to back, nausea and fever. On evaluation, serum pancreatic enzymes were elevated, triglycerides were not raised and ultrasound showed swollen and echogenic pancreas, loss of peripancreatic fat plane and pancreatic duct was not dilated. Vildagliptin was stopped and the pancreatits resolved. On Follow up, no secondary cause was not identified. This appears to be the first reported case of acute pancreatitis from India probably attributable to use of vildagliptin, thus raising the possibility that this rare reaction may be a class effect of the DPP-4 inhibitors.
authors.affiliation: Calcutta Medical Research Institute, West Bengal, India.
authors.forename: Ravikant
authors.initials: R
authors.lastname: Saraogi
authors.forename: Ritwika
authors.initials: R
authors.lastname: Mallik
authors.forename: Sujoy
authors.initials: S
authors.lastname: Ghosh
keywords: India; Vildagliptin; pancreatitis
references.citation: Vasc Health Risk Manag. 2008;4(4):753-68
references.pmid: 19065993
references.citation: Diabetes Obes Metab. 2010 Jun;12(6):495-509
references.pmid: 20518805
references.citation: Endocr Pract. 2011 May-Jun;17(3):e48-50
references.pmid: 21324812