title: Cytotoxic and antibacterial cembranoids from a South China Sea soft coral, Lobophytum sp.
abstract: Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*, 4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E, 11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*,7S*,14S*, 3E,11E)-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 4-14. The structures of the new compounds were elucidated through extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1-3 exhibited moderate cytotoxic activity against the selected tumor cell lines. Moreover, 2 and 3 were found to be moderate inhibitors against the bacteria S. aureus and S. pneumoniae.
authors.affiliation: School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China. miniezhao@gmail.com
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Jian
authors.initials: J
authors.lastname: Yin
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Minshan
authors.initials: M
authors.lastname: Ma
authors.forename: Xinxiang
authors.initials: X
authors.lastname: Lei
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xiang
authors.forename: Jianyong
authors.initials: J
authors.lastname: Dong
authors.forename: Kexin
authors.initials: K
authors.lastname: Huang
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Yan
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004224:Diterpenes
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