title: Bacteria-adsorbed palygorskite stabilizes the quaternary phosphonium salt with specific-targeting capability, long-term antibacterial activity, and lower cytotoxicity.
abstract: In order to extend the antibacterial time of quaternary phosphonium salt in bacteria, palygorskite (PGS) is used as the carrier of dodecyl triphenyl phosphonium bromide (DTP), and a DTP-PGS hybrid is prepared. Antibacterial performance of this novel hybrid is investigated for both Gram-positive and Gram-negative bacteria. The results show that the DTP could be absorbed on the surface of PGS which had bacteria-adsorbed capability. The DTP-PGS hybrid, combining the advantages of PGS and DTP, display specific-targeting capability, long-term antibacterial activity, and lower cytotoxicity, suggesting the great potential application as PGS-based antibacterial powder.
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Cai
authors.forename: Jinglin
authors.initials: J
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Ouyang
authors.forename: Dong
authors.initials: D
authors.lastname: Ma
authors.forename: Shaozao
authors.initials: S
authors.lastname: Tan
authors.forename: Yilong
authors.initials: Y
authors.lastname: Peng
mesh_terms: D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000737:chemistry / Q000187:drug effects* / Q000254:growth & development; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017616:Magnesium Compounds / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D063065:Organophosphonates / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D017655:Silicon Compounds / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D017616:Magnesium Compounds; D063065:Organophosphonates; D012492:Salts; D017655:Silicon Compounds; C026325:attapulgite