title: Effect of ginger extract on liver damage in experimental obstructive jaundice produced by main bile duct ligation.
abstract: BACKGROUND
  Obstructive jaundice is one of the most important surgical causes of childhood jaundices. The aim of this study is to investigate effects of ginger (Gingiber officinalis) extracts on liver damage in experimental obstructive jaundice produced by main bile duct ligation.
  
  
  METHODS
  Forty two Wistar-albino rats were randomly allocated into 7 groups (n = 6). Nothing was performed in the control (C) group. Only laparatomy was performed in the sham (Sh) group. The ginger 1 and 2 (G1 and G2) groups received only 100 and 200 mg/kg/day doses of ginger extract for 1 week orally. In study group, common bile duct ligation was done. In treatment 1 and 2 (T1 and T2) groups common bile duct ligation was followed by administration of 100 and 200 mg/kg/day doses of ginger extract for 1 week orally from the third post operative day, respectively. Blood samples and liver were harvested in order to evaluate the serum aspartate aminotransferase (AST), alanine amino transferase (ALT), gama glutamyltransferase (GGT), total bilirubin (bil), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA) and liver tissue SOD, GSH, MDA levels and liver apoptosis. Results were analyzed by Mann-Whitney U test statistically.
  
  
  RESULTS
  Ginger administration did not result in any differences of serum or tissue levels of the studied parameters and liver apoptosis between the groups statistically (except AST levels in group T2). Tissue GSH and serum SOD levels were only mildly increased in groups receiving ginger alone.
  
  
  CONCLUSIONS
  There is no evidence for protective, inhibitive and decreasing effects of ginger extract on liver injury in experimental obstructive jaundice with these findings.
authors.affiliation: Department of Pediatric Surgery, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Altug
authors.forename: K
authors.initials: K
authors.lastname: Sonmez
authors.forename: Z
authors.initials: Z
authors.lastname: Turkyilmaz
authors.forename: R
authors.initials: R
authors.lastname: Karabulut
authors.forename: O
authors.initials: O
authors.lastname: Gulbahar
authors.forename: G
authors.initials: G
authors.lastname: Yilmaz
authors.forename: U
authors.initials: U
authors.lastname: Ercin
authors.forename: A
authors.initials: A
authors.lastname: Can Basaklar
mesh_terms: D000818:Animals; D001652:Bile Ducts / Q000601:surgery; D004195:Disease Models, Animal; D020939:Zingiber officinale; D006801:Humans; D041781:Jaundice, Obstructive / Q000188:drug therapy*; D008026:Ligation; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D013482:Superoxide Dismutase