title: Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.
abstract: Neurofibrillary tangles (NFTs) are one of the key histological lesions of Alzheimer's disease (AD) and are associated with brain atrophy. We assessed regional NFT density in 30 patients with AD, 10 of which presented as the logopenic variant of primary progressive aphasia (lvPPA) and 20 that presented as dementia of the Alzheimer's type (DAT). Regional grey matter volumes were measured using antemortem MRI. NFT density was significantly higher in left temporoparietal cortices in lvPPA compared to DAT, with no differences observed in hippocampus. There was a trend for the ratio of temporoparietal-to-hippocampal NFT density to be higher in lvPPA. The imaging findings mirrored the pathological findings, with smaller left temporoparietal volumes observed in lvPPA compared to DAT, and no differences observed in hippocampal volume. This study demonstrates that lvPPA is associated with a phenomenon of enhanced temporoparietal neurodegeneration, a finding that improves our understanding of the biological basis of lvPPA.
authors.affiliation: Department of Neurology (Behavioral Neurology), Mayo Clinic, 200 First St. SW, Rochester, MN 55905, United States; Department of Neurology (Movement Disorders), Mayo Clinic, 200 First St. SW, Rochester, MN 55905, United States. Electronic address: josephs.keith@mayo.edu.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.forename: Melissa E
authors.initials: ME
authors.lastname: Murray
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Senjem
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Parisi
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Whitwell
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D018888:Aphasia, Primary Progressive / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016874:Neurofibrillary Tangles / Q000473:pathology*
keywords: Alzheimer’s dementia; Alzheimer’s disease; Apolipoprotein E; Hippocampus; Logopenic variant of primary progressive aphasia; MRI; Neurofibrillary tangles; Primary progressive aphasia; TDP-43; Voxel-based morphometry
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