title: Inducing rapid cellular response on RGD-binding threaded macromolecular surfaces.
abstract: The rapid response of integrin β1 molecules to an RGD peptide on a dynamic polyrotaxane surface was successfully induced. As a result, RGD peptides introduced on a highly dynamic cyclodextrin molecule enhanced the frequency of contact with specific integrin molecules on the cell membrane at the early stage of material-cell interactions.
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan.
authors.forename: Ji-Hun
authors.initials: JH
authors.lastname: Seo
authors.forename: Sachiro
authors.initials: S
authors.lastname: Kakinoki
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Inoue
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Yamaoka
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Yui
mesh_terms: D002448:Cell Adhesion; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism*; D013499:Surface Properties; D013997:Time Factors; D047391:alpha-Cyclodextrins / Q000378:metabolism
chemical_list: D016023:Integrins; D009842:Oligopeptides; D047391:alpha-Cyclodextrins; C047981:arginyl-glycyl-aspartic acid