title: Focal fibrosis of the breast diagnosed by core needle biopsy under imaging guidance.
abstract: BACKGROUND
  Focal fibrosis of the breast is an uncommon pathology, recognition of this lesion is important because it could mimic malignant lesions on both mammogram and ultrasonography (US). Concordance with the pathology result from core needle biopsy (CNB) and follow-up are essential to avoid false negative.
  
  
  OBJECTIVE
  To characterize the mammographic and US features of focal fibrosis of the breast and to estimate the false negative rate for breast cancer when focal fibrosis was diagnosed by CNB.
  
  
  METHODS
  The subjects were 82 patients diagnosed fibrosis of the breast by CNB during 7-year period.
  
  
  RESULTS
  Of 38 mammographic visible lesions there were mass lesions in 12 (32%), calcifications in 14 (37%), mass with calcifications in four (11%), architectural distortion in one (3%) and asymmetrical density in seven (18%). Most of the lesions seen on the US were hypoechoic mass (81%). The suspicious features, which warrant CNB, included irregular shape in 37 (55%), indistinct margin in 38 (57%), and posterior shadowing in 28 (42%). Most of the lesions were categorized as Breast Imaging Reporting and Data System (BI-RADS) 4A (59%). Thirteen cases underwent surgical biopsy and all showed benign pathologic results. No false-negative cases were detected.
  
  
  CONCLUSIONS
  Focal fibrosis had some features similar to malignant lesion. CNB showed reliable pathological result. No false negative result was found in the present study.
authors.affiliation: Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. cholatipp@gmail.com
authors.forename: Cholatip
authors.initials: C
authors.lastname: Wiratkapun
authors.forename: Orapin
authors.initials: O
authors.lastname: Chansanti
authors.forename: Bussanee
authors.initials: B
authors.lastname: Wibulpolprasert
authors.forename: Panuwat
authors.initials: P
authors.lastname: Lertsittichai
mesh_terms: D000328:Adult; D000368:Aged; D062005:Biopsy, Large-Core Needle; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology; D002114:Calcinosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology*; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D011237:Predictive Value of Tests; D013785:Thailand; D018084:Ultrasonography, Interventional; D016217:Ultrasonography, Mammary