title: Structure Activity Relationship Study of the Cleistriosides and Cleistetrosides for Antibacterial/Anticancer Activity.
abstract: Two known cleistriosides and six known cleistetrosides were synthesized and evaluated for anticancer and antibacterial activity. This study, for the first time, reports anticancer activity and comprehensively the antibacterial activity for these oligosaccharide natural products. In addition, two new unnatural cleistetroside analogues were synthesized and tested. Biological activities for the ten oligosaccharides againstB. subtiliswere found to range between 4 and >64 µM, and for NCI-H460 human lung cancer epithelial cells between 7.5 and 90.9 µM. Similar activities were found for seven of the oligosaccharides against the NCI panel of 60 cell lines. The degree of acylation and location of the specific acetate groups had significant effects on the anticancer and antibacterial activity of both the cleistriosides and cleistetrosides.
authors.affiliation: Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.
authors.forename: Pei
authors.initials: P
authors.lastname: Shi
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Silva
authors.forename: Hua-Yu Leo
authors.initials: HY
authors.lastname: Wang
authors.forename: Bulan
authors.initials: B
authors.lastname: Wu
authors.forename: Novruz G
authors.initials: NG
authors.lastname: Akhmedov
authors.forename: Miaosheng
authors.initials: M
authors.lastname: Li
authors.forename: Penny J
authors.initials: PJ
authors.lastname: Beuning
authors.forename: George A
authors.initials: GA
authors.lastname: O'Doherty
keywords: Cleistetroside; Cleistrioside; Palladium-catalyzed glycosylation; antibacterial; anticancer
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