title: Feature extraction across individual time series observations with spikes using wavelet principal component analysis.
abstract: Clinical studies frequently include repeated measurements of individuals, often for long periods. We present a methodology for extracting common temporal features across a set of individual time series observations. In particular, the methodology explores extreme observations within the time series, such as spikes, as a possible common temporal phenomenon. Wavelet basis functions are attractive in this sense, as they are localized in both time and frequency domains simultaneously, allowing for localized feature extraction from a time-varying signal. We apply wavelet basis function decomposition of individual time series, with corresponding wavelet shrinkage to remove noise. We then extract common temporal features using linear principal component analysis on the wavelet coefficients, before inverse transformation back to the time domain for clinical interpretation. We demonstrate the methodology on a subset of a large fetal activity study aiming to identify temporal patterns in fetal movement (FM) count data in order to explore formal FM counting as a screening tool for identifying fetal compromise and thus preventing adverse birth outcomes.
authors.affiliation: Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
authors.forename: Jo
authors.initials: J
authors.lastname: Røislien
authors.forename: Brita
authors.initials: B
authors.lastname: Winje
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D003627:Data Interpretation, Statistical; D005260:Female; D005324:Fetal Movement / Q000502:physiology; D005333:Fetus; D006801:Humans; D008137:Longitudinal Studies / Q000379:methods*; D011247:Pregnancy; D025341:Principal Component Analysis; D013997:Time Factors
keywords: fetal movement; multiple imputation; principal component analysis; spikes; temporal observations; wavelets