title: "Dilute & shoot" approach for rapid determination of trace amounts of nicotine in zero-level e-liquids by reversed phase liquid chromatography and hydrophilic interactions liquid chromatography coupled with tandem mass spectrometry-electrospray ionization.
abstract: Two analytical procedures are proposed where HILIC and RPLC techniques are coupled with tandem mass spectrometry detection for rapid determination of trace amounts of nicotine in zero-level liquids for electronic cigarettes. Samples are prepared on the basis of the approach "dilute & shoot" which makes this important step quick and not complicated. The chromatographic separation was carried out on a Zorbax XDB column (RPLC method) and Ascentis Si column (HILIC mode). Within-run precisions (CVs) measured at three concentration levels were as follows: 0.73%, 0.98% and 1.44% for RPLC method and 1.39%, 1.44% and 0.57% (HILIC mode). Between-run CVs were as follows: 1.94%, 1.02% and 1.22% for RPLC mode and 1.49%, 1.20% and 1.22% for HILIC mode. The detection limits of RPLC and HILIC modes were 4.08 and 3.90 ng/mL respectively. The proposed procedures are rapid, not complicated, sensitive and are suitable for fast determination of trace amounts of nicotine in zero-level liquids for electronic cigarettes.
authors.affiliation: Department of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, Poland. pawel.kubica.pg@gmail.com
authors.forename: Paweł
authors.initials: P
authors.lastname: Kubica
authors.forename: Agata
authors.initials: A
authors.lastname: Kot-Wasik
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wasik
authors.forename: Jacek
authors.initials: J
authors.lastname: Namieśnik
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D056148:Chromatography, Reverse-Phase / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D009538:Nicotine / Q000032:analysis*; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods*; D062789:Tobacco Products / Q000032:analysis*
chemical_list: D009538:Nicotine