title: Immune-mediated cytopenias in human immunodeficiency virus: the first reported case of idiopathic aplastic anaemia successfully treated with immunosuppression.
abstract: Although isolated cytopenias are relatively common in human immunodeficiency virus (HIV), the incidence of aplastic anaemia is extremely rare. We report here the first case of a HIV-infected patient who developed severe idiopathic aplastic anaemia, and who was safely and effectively treated with anti-thymocyte globulin and cyclosporin. We briefly review immune-mediated cytopenias in HIV, including their frequency, pathophysiology and management strategies.
authors.affiliation: Department of Clinical Haematology, Monash Medical Centre, Melbourne, Victoria, Australia. greghapgood@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: Hapgood
authors.forename: J F
authors.initials: JF
authors.lastname: Hoy
authors.forename: C O
authors.initials: CO
authors.lastname: Morrissey
authors.forename: S M
authors.initials: SM
authors.lastname: Jane
mesh_terms: D000741:Anemia, Aplastic / Q000188:drug therapy* / Q000209:etiology* / Q000276:immunology; D000961:Antilymphocyte Serum / Q000008:administration & dosage; D016572:Cyclosporine / Q000008:administration & dosage; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D016572:Cyclosporine