title: Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems.
abstract: We present new supramolecular complexes of two different solid forms of furosemide (I or II) with maltodextrin, in order to explore their application as delivery systems improving the bioavailability of the drug. The complexation in solution was evaluated by (1)H nuclear magnetic resonance experiments and phase solubility studies. The products in solid state were exhaustively characterized by using spectroscopic techniques ((13)C solid state nuclear magnetic resonance, infrared, scanning electron microscopy, X-ray powder diffractometry) and thermal analysis. (1)H relaxation times experiments gave further support in distinguishing the new solid forms. Dissolution studies in simulated gastric fluid showed that both supramolecular complexes presented significant increase in the dissolution, while the corresponding physical mixtures exhibited the most discriminating conditions between the furosemide forms I and II. Our results suggest the enhancement of the solubility and the dissolution of furosemide in the new complexes, making them promising candidates for the preparation of alternative matrices in oral pharmaceutical formulations.
authors.affiliation: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, X5000HUA Córdoba, Argentina.
authors.forename: Claudia
authors.initials: C
authors.lastname: Garnero
authors.forename: Ana Karina
authors.initials: AK
authors.lastname: Chattah
authors.forename: Marcela
authors.initials: M
authors.lastname: Longhi
mesh_terms: D002152:Calorimetry, Differential Scanning; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry*; D005665:Furosemide / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000737:chemistry*; D033362:Powder Diffraction; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D011134:Polysaccharides; C008315:maltodextrin; D005665:Furosemide