title: Activation of transposable elements during aging and neuronal decline in Drosophila.
abstract: We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
authors.forename: Wanhe
authors.initials: W
authors.lastname: Li
authors.forename: Lisa
authors.initials: L
authors.lastname: Prazak
authors.forename: Nabanita
authors.initials: N
authors.lastname: Chatterjee
authors.forename: Servan
authors.initials: S
authors.lastname: Grüninger
authors.forename: Lisa
authors.initials: L
authors.lastname: Krug
authors.forename: Delphine
authors.initials: D
authors.lastname: Theodorou
authors.forename: Josh
authors.initials: J
authors.lastname: Dubnau
mesh_terms: D000375:Aging / Q000235:genetics / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D030801:Animals, Genetically Modified; D060565:Argonaute Proteins / Q000235:genetics*; D001362:Avoidance Learning / Q000502:physiology; D001921:Brain; D003214:Conditioning, Classical / Q000502:physiology; D004251:DNA Transposable Elements / Q000235:genetics*; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics*; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D008136:Longevity / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D009474:Neurons / Q000502:physiology*
chemical_list: C433807:AGO2 protein, Drosophila; D060565:Argonaute Proteins; D004251:DNA Transposable Elements; D029721:Drosophila Proteins; D049452:Green Fluorescent Proteins
references.citation: Curr Biol. 2007 Apr 3;17(7):637-42
references.pmid: 17363252
references.citation: Cell. 2008 Oct 3;135(1):23-35
references.pmid: 18854152
references.citation: PLoS Comput Biol. 2008 Feb 29;4(2):e1000026
references.pmid: 18463699
references.citation: Neuron. 2002 Aug 29;35(5):951-60
references.pmid: 12372288
references.citation: Nature. 2011 Oct 30;479(7374):534-7
references.pmid: 22037309
references.citation: Genes Dev. 1994 Sep 1;8(17):2046-57
references.pmid: 7958877
references.citation: Hum Mol Genet. 2012 Jan 1;21(1):57-65
references.pmid: 21940752
references.citation: Genome Res. 2008 Mar;18(3):343-58
references.pmid: 18256243
references.citation: Ann Neurol. 2011 Jan;69(1):141-51
references.pmid: 21280084
references.citation: Curr Biol. 2012 Apr 10;22(7):608-14
references.pmid: 22425153
references.citation: Nat Rev Genet. 2011 Jan;12(1):19-31
references.pmid: 21116305
references.citation: Genetics. 2008 Nov;180(3):1367-78
references.pmid: 18791225
references.citation: Nature. 2010 Nov 18;468(7322):443-6
references.pmid: 21085180
references.citation: Nature. 2012 Feb 15;482(7386):519-23
references.pmid: 22343898
references.citation: J Clin Virol. 2010 Feb;47(2):136-42
references.pmid: 20005155
references.citation: Cell. 1994 Oct 7;79(1):35-47
references.pmid: 7923375
references.citation: Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20382-7
references.pmid: 22159035
references.citation: J Mol Biol. 2009 Sep 25;392(3):813-22
references.pmid: 19631225
references.citation: PLoS One. 2012;7(9):e44099
references.pmid: 22957047
references.citation: Nature. 2005 Jun 16;435(7044):903-10
references.pmid: 15959507
references.citation: Nature. 2011 Mar 17;471(7338):325-30
references.pmid: 21297615
references.citation: Nature. 2009 Aug 27;460(7259):1127-31
references.pmid: 19657334
references.citation: FEBS Lett. 2011 Oct 3;585(19):3079-85
references.pmid: 21889502