title: Intermediate conformations during viral fusion glycoprotein structural transition.
abstract: Entry of enveloped viruses into cells requires the fusion of viral and cellular membranes, driven by conformational changes in viral glycoproteins. Three different classes of viral fusion proteins have been hitherto identified based on common structural elements. Crystal structures have provided static pictures of pre-fusion and post-fusion conformations of these proteins and have revealed the dramatic reorganization of the molecules, but the transition pathway remains elusive. In this review, we will focus on recent data aiming to characterize intermediate structures during the conformational change. All these data support the existence of a pre-hairpin intermediate, but its oligomeric status is still a matter of debate.
authors.affiliation: Centre de Recherche de Gif, Laboratoire de Virologie Moléculaire et Structurale, CNRS (UPR 3296), 91198 Gif sur Yvette Cedex, France.
authors.forename: Eduard
authors.initials: E
authors.lastname: Baquero
authors.forename: Aurélie A
authors.initials: AA
authors.lastname: Albertini
authors.forename: Patrice
authors.initials: P
authors.lastname: Vachette
authors.forename: Jean
authors.initials: J
authors.lastname: Lepault
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bressanelli
authors.forename: Yves
authors.initials: Y
authors.lastname: Gaudin
mesh_terms: D018360:Crystallography, X-Ray; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation; D014760:Viral Fusion Proteins / Q000737:chemistry* / Q000378:metabolism*; D053586:Virus Internalization
chemical_list: D014760:Viral Fusion Proteins
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