title: A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem.
abstract: We investigated 5 metallo-β-lactamase (MBL)-positive Klebsiella isolates from Japan showing intermediate resistance to imipenem. Sequencing of the MBL gene identified a novel variant of IMP-1 with a single amino acid substitution, Glu87Gly. This variant is designated as IMP-34 where blaIMP-34 is located on a transmissible plasmid.
authors.affiliation: Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima 734-8551, Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Shigemoto
authors.forename: Shizuo
authors.initials: S
authors.lastname: Kayama
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kuwahara
authors.forename: Junzo
authors.initials: J
authors.lastname: Hisatsune
authors.forename: Fuminori
authors.initials: F
authors.lastname: Kato
authors.forename: Hisaaki
authors.initials: H
authors.lastname: Nishio
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Yasunao
authors.initials: Y
authors.lastname: Wada
authors.forename: Taijiro
authors.initials: T
authors.lastname: Sueda
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ohge
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Sugai
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D015378:Imipenem / Q000494:pharmacology*; D007564:Japan; D007709:Klebsiella / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem; D001618:beta-Lactamases