title: [Fever of unknown origin].
abstract: Fever of unknown origin (FUO) is defined as sustained unexplained fever despite intensive diagnostic evaluation and represents a particular diagnostic challenge. It can be classified into different categories, e.g. classical, nosocomial, neutropenic and HIV-associated FUO, which is based on the patient-specific clinical and immunological situation. Infections, malignant diseases and non-infectious inflammatory diseases have to be considered as the most important causes of FUO; however, no definitive diagnosis can be established in a substantial number of FUO patients despite an extensive diagnostic work-up. The present review focuses on the important diagnostic aspects as well as therapeutic options in FUO patients.
authors.affiliation: Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Regensburg, Regensburg, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Salzberger
authors.forename: M
authors.initials: M
authors.lastname: Müller-Schilling
authors.forename: M
authors.initials: M
authors.lastname: Fleck
mesh_terms: D005335:Fever of Unknown Origin / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D009369:Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*
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