title: BF3·OEt2-Promoted Concise Synthesis of Difluoroboron-Derivatized Curcumins from Aldehydes and 2,4-Pentanedione.
abstract: A concise and one-pot cascade method has been developed to achieve the synthesis of difluoroboron-derivatized curcumins (BF2C). Treatment of 2,4-pentanedione with BF3·OEt2, followed by condensation with aldehydes in the presence of tributyl borate and butylamine at 65 °C in toluene furnished the corresponding symmetric (s-BF2C) and unsymmetric difluoroboron-derivatized curcumins (us-BF2C) in good (60 - 99%) and moderate yields (23 - 42%) within 6 - 12 h, respectively.
authors.affiliation: Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23298.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Jiangmin
authors.initials: J
authors.lastname: Chen
authors.forename: Jeremy
authors.initials: J
authors.lastname: Chojnacki
authors.forename: Shijun
authors.initials: S
authors.lastname: Zhang
keywords: BF3-Et2O promoted reaction; Curcumin analog; concise synthesis; difluoroboron complex
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