title: Synthetic oligoureas of metaphenylenediamine mimic host defence peptides in their antimicrobial behaviour.
abstract: Oligomeric ureas of m-phenylenediamine target anionic DMPG (dimyristoylphosphatidylglycerol) and possess promise as antimicrobial agents. Their similar size, shape and hydrophobicity to helical antimicrobial peptides (AMPs) may be important for activity to exist and the ability of these compounds to insert into a well ordered lipid environment.
authors.affiliation: School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK.
authors.forename: Sarah R
authors.initials: SR
authors.lastname: Dennison
authors.forename: David A
authors.initials: DA
authors.lastname: Phoenix
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Snape
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010655:Phenylenediamines / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000737:chemistry / Q000378:metabolism; D010715:Phosphatidylglycerols / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary; D013211:Staphylococcus aureus / Q000187:drug effects; D014510:Urease / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D010655:Phenylenediamines; D010714:Phosphatidylethanolamines; D010715:Phosphatidylglycerols; C002773:dimyristoylphosphatidylglycerol; D014510:Urease; C008381:3-phenylenediamine; C018525:1,2-dimyristoylphosphatidylethanolamine