title: Assembly of the type II secretion system.
abstract: The type II secretion system is utilized by many Gram-negative bacteria to export folded proteins to the surface and/or the extracellular environment of the cell. Although the function of the system is to move proteins from the periplasm to the outside of the cell, it is a large trans-envelope structure composed of more than a dozen different proteins present in multiple copies, including peripheral, integral inner membrane and integral outer membrane proteins plus a pseudopilus stretching between them. The establishment of this structure as an integral component of the entire envelope including the peptidoglycan layer between the two membranes requires assembly. Many of the participants and processes involved in this assembly have now been established, while other aspects remain to be discovered or more fully understood.
authors.affiliation: Department of Microbiology and Immunology, University of Saskatchewan, Health Sciences Building, Room 2D01, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5. peter.howard@usask.ca
authors.forename: S
authors.initials: S
authors.lastname: Peter Howard
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D058947:Bacterial Secretion Systems; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000235:genetics / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism; D021381:Protein Transport
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D026901:Membrane Transport Proteins
keywords: Assembly; Membrane complex; Pseudopilus; Secretin; Type II secretion