title: The impact of viral infections in children with community-acquired pneumonia.
abstract: For many years viral causes of community-acquired pneumonia were often been given limited attention. The number of published studies on influenza alone increased fivefold from 2001 to 2010. Specifically several studies have underlined that the involvement of viruses in community-acquired pneumonia has been underestimated, and this underestimation has been attributed to a lack of appropriate diagnostic methods. Now, with the advent of modern molecular assays, it is well recognized that viruses account for the largest proportion of community-acquired pneumonia in preschool children in both developed and developing countries. Respiratory syncytial virus, influenza virus, adenovirus, and parainfluenza virus are the major pathogens involved, but the relative importance of additional viruses (rhinoviruses, bocavirus, human metapneumovirus) is increasing and will be better defined by future research.
authors.affiliation: Department of Pediatrics, L. Sacco Hospital, University of Milan, via G.B. Grassi 74, 20157, Milano, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Mameli
authors.forename: Gian Vincenzo
authors.initials: GV
authors.lastname: Zuccotti
references.citation: S Afr Med J. 2002 Nov;92(11):907-11
references.pmid: 12506595
references.citation: Clin Infect Dis. 2012 Apr;54 Suppl 2:S190-9
references.pmid: 22403235
references.citation: Clin Infect Dis. 2011 Oct;53(7):617-30
references.pmid: 21890766
references.citation: Eur J Clin Microbiol Infect Dis. 2012 Jul;31(7):1637-45
references.pmid: 22124536
references.citation: J Med Virol. 2012 Feb;84(2):253-8
references.pmid: 22170545
references.citation: Clin Infect Dis. 2004 Sep 1;39(5):681-6
references.pmid: 15356783
references.citation: Scand J Infect Dis. 2005;37(11-12):806-12
references.pmid: 16308213
references.citation: J Clin Microbiol. 2002 Sep;40(9):3115-20
references.pmid: 12202540
references.citation: PLoS One. 2012;7(2):e32056
references.pmid: 22384139
references.citation: Chang Gung Med J. 2005 Oct;28(10):683-8
references.pmid: 16382752
references.citation: Southeast Asian J Trop Med Public Health. 2001 Sep;32(3):513-9
references.pmid: 11944709
references.citation: Eur J Clin Microbiol Infect Dis. 2012 Nov;31(11):3251-6
references.pmid: 22790539
references.citation: Scand J Infect Dis. 2006;38(8):690-5
references.pmid: 16857616
references.citation: Virol J. 2012 Apr 10;9:78
references.pmid: 22490115
references.citation: Expert Rev Mol Diagn. 2002 Jul;2(4):329-36
references.pmid: 12138497
references.citation: J Infect Dis. 2007 Apr 1;195(7):1038-45
references.pmid: 17330795
references.citation: Clin Infect Dis. 2002 Mar 1;34(5):583-90
references.pmid: 11803504
references.citation: Acta Paediatr. 2010 Nov;99(11):1602-8
references.pmid: 20573146
references.citation: CMAJ. 2011 Feb 8;183(2):215-9
references.pmid: 21135076
references.citation: J Pediatr. 2010 Jan;156(1):115-20
references.pmid: 19782998
references.citation: MMWR Morb Mortal Wkly Rep. 2009 Jan 16;58(1):1-4
references.pmid: 19145219
references.citation: Influenza Other Respir Viruses. 2011 Jul;5(4):285-7
references.pmid: 21651739
references.citation: Influenza Other Respir Viruses. 2013 Jan;7(1):18-26
references.pmid: 22329841
references.citation: Pediatr Infect Dis J. 1993 Jan;12(1):10-4
references.pmid: 8380234
references.citation: Curr Opin Pulm Med. 2012 May;18(3):271-8
references.pmid: 22366993
references.citation: PLoS One. 2012;7(8):e43666
references.pmid: 22912897
references.citation: N Engl J Med. 2002 Feb 7;346(6):429-37
references.pmid: 11832532
references.citation: Pediatr Infect Dis J. 2013 Jan;32(1):e8-13
references.pmid: 22926214
references.citation: Clin Infect Dis. 2011 May;52 Suppl 4:S284-9
references.pmid: 21460286
references.citation: J Virol. 2012 Oct;86(19):10888-9
references.pmid: 22966184
references.citation: J Infect Chemother. 2008 Dec;14(6):424-32
references.pmid: 19089556
references.citation: Pediatr Infect Dis J. 2008 Oct;27(10):939-41
references.pmid: 18756190
references.citation: APMIS. 2002 Aug;110(7-8):515-22
references.pmid: 12390408
references.citation: J Med Virol. 2010 May;82(5):866-72
references.pmid: 20336732
references.citation: Postgrad Med. 2010 Mar;122(2):130-41
references.pmid: 20203464
references.citation: Clin Microbiol Rev. 1994 Oct;7(4):533-58
references.pmid: 7834604
references.citation: Clin Microbiol Rev. 2008 Oct;21(4):716-47
references.pmid: 18854489
references.citation: Pediatr Pulmonol. 2007 Dec;42(12):1095-103
references.pmid: 17588246
references.citation: Pediatr Infect Dis J. 2004 Feb;23(2):118-23
references.pmid: 14872176
references.citation: Lancet. 2011 Apr 9;377(9773):1264-75
references.pmid: 21435708
references.citation: JAMA. 2010 May 26;303(20):2051-7
references.pmid: 20501927
references.citation: Paediatr Respir Rev. 2004;5 Suppl A:S197-200
references.pmid: 14980270
references.citation: Paediatr Respir Rev. 2004;5 Suppl A:S191-5
references.pmid: 14980269
references.citation: Clin Microbiol Infect. 2012 Mar;18(3):300-7
references.pmid: 21851481
references.citation: Epidemiol Infect. 1992 Feb;108(1):147-54
references.pmid: 1312477
references.citation: Clin Infect Dis. 2012 Apr;54 Suppl 2:S132-9
references.pmid: 22403227
references.citation: PLoS Pathog. 2007 Oct 19;3(10):1470-6
references.pmid: 17953482
references.citation: Scand J Infect Dis. 2008;40(10):821-6
references.pmid: 18618373
references.citation: J Microbiol Immunol Infect. 2011 Jun;44(3):184-90
references.pmid: 21524612
references.citation: Clin Microbiol Rev. 2007 Jan;20(1):49-78
references.pmid: 17223623
references.citation: Pediatr Infect Dis J. 2000 Apr;19(4):293-8
references.pmid: 10783017
references.citation: Pediatr Infect Dis J. 2012 Aug;31(8):808-13
references.pmid: 22531244