title: Effect of sugammadex on rocuronium induced changes in pancreatic mast cells.
abstract: Mast cells play a vital role in hypersensitivity reactions. Rocuronium is known to cause mast cell mobilization, hypersensitivity, and pancreatitis. The aim of this study was to investigate the effects of sugammadex on pancreatic changes due to rocuronium. A total of 42 Sprague-Dawley male rats were divided into six equal groups to receive either rocuronium 1 mg/kg intravenously (i.v., R group), rocuronium 1 mg/kg + sugammadex 16 mg/kg i.v. (RS16 group), rocuronium 1 mg/kg + sugammadex 96 mg/kg i.v. (RS96 group), sugammadex 16 mg/kg (S16), sugammadex 96 mg/kg i.v. (S96 group), or 0.9% sodium chloride (control group). Sugammadex was administered 5s later following rocuronium. In R group, mast count was higher, and the distribution rate of granules and nuclear changes were different compared with other groups. Distribution rate of granules in groups S16 and S96 were similar to the control group and lower compared with other groups. The amount of mast cells and granule density in groups RS16 and RS96 was lower compared with R group. The amount of mast cells in groups RS16 and RS96 was significantly lower compared with other treatment groups. These results suggest that sugammadex may have an inhibitory effect on mobilization and morphological changes in pancreatic mast cells induced by administration of rocuronium and sugammadex in rats.
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey ykalkan53@gmail.com.
authors.forename: Yıldıray
authors.initials: Y
authors.lastname: Kalkan
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Tumkaya
authors.affiliation: The Ministry of Justice, Institute of Forensic Medicine, Istanbul, Turkey.
authors.forename: Habib
authors.initials: H
authors.lastname: Bostan
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Tomak
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Durdu
authors.initials: D
authors.lastname: Altuner
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Yilmaz
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Başar
authors.initials: B
authors.lastname: Erdivanli
authors.affiliation: Department of Pathology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Bedir
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Yalcin
authors.affiliation: Department of Outcomes Research, Cleveland Clinic, USA.
authors.forename: Alparslan
authors.initials: A
authors.lastname: Turan
mesh_terms: D000732:Androstanols / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D010179:Pancreas / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium
keywords: Sugammadex; pancreatic mast cells; rat; rocuronium