title: Synthesis and reactivity of unsymmetrical azomethine imines formed using alkene aminocarbonylation.
abstract: Complex cyclic azomethine imines possessing a β-aminocarbonyl motif can be accessed readily from simple alkenes and hydrazones. This alkene aminocarbonylation approach allows formation of ketone-derived azomethine imines of unprecedented complexity. Since unsymmetrical hydrazones are used, two stereoisomers are formed: the reactivity of chiral derivatives is explored in both intra- and intermolecular systems.
authors.affiliation: Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Wei
authors.initials: W
authors.lastname: Gan
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Moon
authors.forename: Christian
authors.initials: C
authors.lastname: Clavette
authors.forename: Nicolas
authors.initials: N
authors.lastname: Das Neves
authors.forename: Thomas
authors.initials: T
authors.lastname: Markiewicz
authors.forename: Amy B
authors.initials: AB
authors.lastname: Toderian
authors.forename: André M
authors.initials: AM
authors.lastname: Beauchemin
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006835:Hydrazones / Q000737:chemistry*; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; D001391:Azo Compounds; D006835:Hydrazones; D007097:Imines; D007659:Ketones; D013882:Thiosemicarbazones; C512188:azomethine