title: Prenylated indole diketopiperazine alkaloids from a mangrove rhizosphere soil derived fungus Aspergillus effuses H1-1.
abstract: One new prenylated indole diketopiperazine alkaloid, named dihydroneochinulin B (1), one known spiro-polyketide-diketopiperazine hybrid cryptoechinuline D (2) and three related known metabolites didehydroechinulin B (3), neoechinulin B (4) and auroglaucin (5) were isolated from the mangrove rhizosphere soil derived fungus, Aspergillus effuses H1-1. The structures were assigned by detailed spectroscopic analysis. The enantiomers of cryptoechinuline D (2) were separated to be (+)-cryptoechinuline D (2a) and (-)-cryptoechinuline D (2b) by chiral HPLC, and their absolute configurations were determined by ECD analysis. The cytotoxic effects of the compounds were preliminarily evaluated on P388, HL-60, BEL-7402 and A-549 cell lines by SRB or MTT methods, and compounds 2, 2a and 3 showed significant activities.
authors.affiliation: College of Pharmacy, Binzhou Medical College, Yantai 264003, People's Republic of China.
authors.forename: Huquan
authors.initials: H
authors.lastname: Gao
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.forename: Weizhong
authors.initials: W
authors.lastname: Liu
mesh_terms: D001230:Aspergillus / Q000737:chemistry* / Q000302:isolation & purification; D054659:Diketopiperazines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D054876:Prenylation; D043982:Rhizophoraceae; D058441:Rhizosphere; D012988:Soil Microbiology
chemical_list: D054659:Diketopiperazines; D026121:Indole Alkaloids