title: Asymmetric approach to hyacinthacines B1 and B2.
abstract: Naturally occurring hyacinthacines B1 and B2 have been prepared from a common, easily available, advanced intermediate. The approach features several highly stereoselective transformations: inter alia, a dichloroketene-enol ether [2 + 2] cycloaddition, a Bruylants alkylation, and an amino-nitrile alkylation-reduction.
authors.affiliation: SERCO, Département de Chimie Moléculaire, University Grenoble Alpes, ICMG FR-2607, CNRS, UMR-5250, F-38041 Grenoble, France.
authors.forename: Paidi Venkatram
authors.initials: PV
authors.lastname: Reddy
authors.forename: Julien
authors.initials: J
authors.lastname: Smith
authors.forename: Anushree
authors.initials: A
authors.lastname: Kamath
authors.forename: Hélène
authors.initials: H
authors.lastname: Jamet
authors.forename: Amaël
authors.initials: A
authors.lastname: Veyron
authors.forename: Peter
authors.initials: P
authors.lastname: Koos
authors.forename: Christian
authors.initials: C
authors.lastname: Philouze
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Greene
authors.forename: Philippe
authors.initials: P
authors.lastname: Delair
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D011763:Pyrrolizidine Alkaloids