title: Catalytic Asymmetric Synthesis of Highly Substituted Pyrrolizidines.
abstract: A catalytic asymmetric double (1,3)-dipolar cycloaddition reaction has been developed. Using a chiral silver catalyst, enantioenriched pyrrolizidines can be prepared in one flask from inexpensive, commercially available starting materials. The pyrrolizidine products contain a variety of substitution patterns and as many as six stereogenic centers.
authors.affiliation: The Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA).
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authors.lastname: Lim
authors.forename: Julian A
authors.initials: JA
authors.lastname: Codelli
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Reisman
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