title: Single-dose and multiple-dose pharmacokinetics of zaltoprofen after oral administration in healthy Chinese volunteers.
abstract: Zaltoprofen, a propionic acid derivative of non-steroidal anti-inflammatory drugs, has strong inhibitory effects on actue and chronic inflammation. A randomized, dose-escalating study was conducted to evaluate the pharmacokinetics of single and multiple oral doses of zaltoprofen in 12 healthy Chinese volunteers. Pharmacokinetics was determined from serial blood samples obtained up to 24 h after administration of a single dose of zaltoprofen at 80, 160 or 240 mg and after multiple doses of zaltqorofen at 80 mg 3 times daily. The Cmax and AUC0-24 of zaltoprofen were found to be proportional to drug dose. Zaltoprofen was rapidly absorbed (tmax =1.46±0.83 h) and cleared (t1/2 =4.96±2.97 h). Pharmacokinetic parameters after multiple doses were similar to those after single doses. Zaltoprofen was well tolerated. These results support a tid regimen of zaltoprofen for the management of acute and chronic inflammation.
authors.affiliation: Department of Pharmacology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, China.
authors.forename: Lingjun
authors.initials: L
authors.lastname: Li
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Ma
authors.forename: Yuping
authors.initials: Y
authors.lastname: Cao
authors.forename: Lei
authors.initials: L
authors.lastname: Tao
authors.forename: Yue
authors.initials: Y
authors.lastname: Tao
keywords: nonsteroidal anti-inflammatory drug; pharmacokinetics; zaltoprofen
references.citation: Arzneimittelforschung. 1986 Dec;36(12):1796-800
references.pmid: 3566840
references.citation: Neurosci Lett. 2006 Apr 24;397(3):249-53
references.pmid: 16406342
references.citation: Arzneimittelforschung. 1987 Jan;37(1):19-26
references.pmid: 3494460
references.citation: Rapid Commun Mass Spectrom. 2006;20(18):2675-80
references.pmid: 16912985
references.citation: Arzneimittelforschung. 1986 Dec;36(12):1801-5
references.pmid: 3105545