title: "Sugarcoated haws on a stick"-like MWNTs-Fe3O4-C coaxial nanomaterial: synthesis, characterization and application in electrochemiluminescence immunoassays.
abstract: In this paper, a carbon coated magnetic nanoparticle (Fe3O4-C) was first synthesized via solvothermal reaction and carbonization of glucose under hydrothermal condition. The electrochemiluminescence (ECL) property of Fe3O4-C was studied, and exhibited a peak at 1.21V. In the goal to amplify the ECL intensity for sensitive detection, a novel coaxial carbon coated magnetic nanomaterial (MWNTs-Fe3O4-C) was synthesized. Fourier transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), powder X-ray diffraction (XRD) and powder X-ray photoelectron spectrometry (XPS) were applied as powerful tools to characterize and to demonstrate the named nanomaterial. MWNTs-Fe3O4-C showed better ECL property than Fe3O4-C. Furthermore, an ultrasensitive ECL immunosensor based on MWNTs-Fe3O4-C was developed for the determination of carcinoembryonic antigen (CEA). The prepared ECL immunosensor exhibited high sensitivity, good reproducibility, long-term stability, and acceptable precision on the detection of CEA in clinical human serum samples.
authors.affiliation: Key Laboratory of Chemical Sensing and Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.
authors.forename: Chengchao
authors.initials: C
authors.lastname: Chu
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Shenguang
authors.initials: S
authors.lastname: Ge
authors.forename: Lei
authors.initials: L
authors.lastname: Ge
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yu
authors.forename: Mei
authors.initials: M
authors.lastname: Yan
authors.forename: Xianrang
authors.initials: X
authors.lastname: Song
authors.forename: Long
authors.initials: L
authors.lastname: Li
authors.forename: Baohai
authors.initials: B
authors.lastname: Han
authors.forename: Jianxiu
authors.initials: J
authors.lastname: Li
mesh_terms: D015374:Biosensing Techniques; D002244:Carbon / Q000737:chemistry; D002272:Carcinoembryonic Antigen / Q000097:blood / Q000302:isolation & purification*; D005290:Ferric Compounds / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D007118:Immunoassay; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D002272:Carcinoembryonic Antigen; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D002244:Carbon