title: Serum lipid-improving effect of soyabean β-conglycinin in hyperlipidaemic menopausal women.
abstract: To evaluate the effect of treatment with β-conglycinin, a major soyabean protein, on blood lipids in menopausal women, we recruited 100 hyperlipidaemic women aged 40-60 years old. Participants were randomly allocated to three groups: placebo group (n 34, four casein tablets/d); low dose group (n 33, four tablets containing 2·3 g β-conglycinin/d); high-dose group (n 33, eight tablets containing 4·6 g β-conglycinin/d). The mean serum TAG concentration was significantly reduced after 6 and 12 weeks of β-conglycinin intervention by 0·44 (sd 0·20) and 0·78 (sd 1·03) mmol/l in the low-dose group, and by 0·46 (sd 0·17) and 1·25 (sd 1·06) mmol/l in the high-dose group, respectively. One-way ANOVA revealed that serum TAG concentrations in the low-dose and high-dose groups were significantly lowered compared with the placebo group at weeks 6 and 12 (P< 0·05). The low dose and high dose consumptions of β-conglycinin significantly decreased the LDL-cholesterol concentration by 0·46 (sd 0·72) and 0·52 (sd 0·97) mmol/l at week 12, respectively (P< 0·05). Compared with the changes from baseline in the placebo group, apoB and NEFA were significantly lowered in both the low-dose and high-dose β-conglycinin groups (P< 0·05). In conclusion, the results suggest that β-conglycinin intake significantly decreases serum TAG and LDL-cholesterol levels.
authors.affiliation: Department of Social Medicine and Health Education, School of Public Health, Peking University Health Science Center, Beijing 100191, People's Republic of China.
authors.forename: Defu
authors.initials: D
authors.lastname: Ma
authors.forename: Kyoko
authors.initials: K
authors.lastname: Taku
authors.forename: Yumei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Meng
authors.initials: M
authors.lastname: Jia
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Peiyu
authors.initials: P
authors.lastname: Wang
mesh_terms: D000704:Analysis of Variance; D052179:Antigens, Plant / Q000494:pharmacology / Q000627:therapeutic use*; D001055:Apolipoproteins B / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005916:Globulins / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D008593:Menopause; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D055314:Seed Storage Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D030262:Soybean Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D013025:Glycine max / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood*
chemical_list: D052179:Antigens, Plant; D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D005230:Fatty Acids, Nonesterified; D005916:Globulins; D010936:Plant Extracts; D055314:Seed Storage Proteins; D030262:Soybean Proteins; D014280:Triglycerides; C013894:beta-conglycinin protein, Glycine max