title: [Transporter-mediated regulation of pharmacokinetics of lifestyle-related substances].
abstract: Recent studies revealed the importance of transporters in the behaviors of small molecules in the body. In mammals, the presence of a lot of transporters has been suggested, such as ATP-binding cassette (ABC) transporters and solute ligand carrier (SLC) transporters, some of which are clarified to be causative genes for various kinds of genetic disorders. In addition, a lot of transporters are known to mediate cellular import or export of drugs, to contribute to the pharmacokinetics of substrate drugs and to be involved in the interindividual differences of drug responses. In this review, I introduce our recent work on the transporter-mediated regulation of pharmacokinetics of lifestyle-related substances, such as cholesterol and urate.
authors.affiliation: Department of Pharmacy, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
authors.forename: Tappei
authors.initials: T
authors.lastname: Takada
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000502:physiology*; D000818:Animals; D001384:Azetidines / Q000493:pharmacokinetics; D001692:Biological Transport; D002784:Cholesterol / Q000493:pharmacokinetics*; D000069438:Ezetimibe; D006801:Humans; D008019:Life Style; D008099:Liver / Q000378:metabolism; D008565:Membrane Proteins / Q000502:physiology*; D026901:Membrane Transport Proteins; D009363:Neoplasm Proteins / Q000502:physiology*; D014527:Uric Acid / Q000493:pharmacokinetics*
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D001384:Azetidines; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C410800:NPC1L1 protein, human; D009363:Neoplasm Proteins; D014527:Uric Acid; D002784:Cholesterol; D000069438:Ezetimibe