title: Unequivocal role of pyrazine ring in medicinally important compounds: a review.
abstract: Pyrazine is one of the important class of heterocyclic compounds that can be obtained naturally or synthesized chemically. Pyrazine ring has got importance in exhibiting various biological activities in association with other scaffolds like pyrrole, pyrazole, imidazole, triazole, tetrazole, thiophene, oxazole, pyridine, piperidine and piperazine. Presence of pyrazine ring as a basic scaffold in various clinically used drugs exhibits its importance in drug design. In this review, attempt has been made to disclose various therapeutic applications of pyrazine derivatives reported during the last decade.
authors.affiliation: Department of Pharm. Chem. Sinhgad Institute of Pharmacy, Narhe, Pune- 411041, India. pankajmpharm@yahoo.co.in
authors.forename: Pankaj B
authors.initials: PB
authors.lastname: Miniyar
authors.forename: Prashant R
authors.initials: PR
authors.lastname: Murumkar
authors.forename: Pallavi S
authors.initials: PS
authors.lastname: Patil
authors.forename: Mahesh A
authors.initials: MA
authors.lastname: Barmade
authors.forename: Kailash G
authors.initials: KG
authors.lastname: Bothara
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000188:drug therapy; D004232:Diuretics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D004232:Diuretics; D007004:Hypoglycemic Agents; D047428:Protein Kinase Inhibitors; D011719:Pyrazines