title: Effect of cyclophosphamide and morin-5'-sulfonic acid sodium salt, alone or in combination, on ADMA/DDAH pathway in rats.
abstract: BACKGROUND
  The aim of the study was to evaluate the effect of cyclophosphamide (CPX) and morin-5'-sulfonic acid sodium salt (NaMSA) on plasma asymmetric dimethylarginine (ADMA) level and dimethylarginine dimethylaminohydrolase (DDAH) activity in rat liver.
  
  
  METHODS
  The study was performed on Wistar rats receiving normal saline, CPX (15 mg/kg/day), NaMSA (100 mg/kg/day) or both CPX and NaMSA for 10 consecutive days.
  
  
  RESULTS
  Significant decrease in ADMA level was found in all groups when compared to the control. DDAH activity in the liver was significantly higher in CX group compared to the control group.
  
  
  CONCLUSIONS
  Obtained results of ADMA/DDAH pathway parameters require further research.
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, PL 50-345 Wrocław, Poland. amerwid@mp.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Merwid-Ląd
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Trocha
authors.forename: Ewa
authors.initials: E
authors.lastname: Chlebda-Sieragowska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sozański
authors.forename: Jan
authors.initials: J
authors.lastname: Magdalan
authors.forename: Dorota
authors.initials: D
authors.lastname: Ksiądzyna
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szuba
authors.forename: Maria
authors.initials: M
authors.lastname: Kopacz
authors.forename: Anna
authors.initials: A
authors.lastname: Kuźniar
authors.forename: Dorota
authors.initials: D
authors.lastname: Nowak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pieśniewska
authors.forename: Lidia
authors.initials: L
authors.lastname: Fereniec-Gołębiewska
authors.forename: Adam
authors.initials: A
authors.lastname: Szeląg
mesh_terms: D000581:Amidohydrolases / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013451:Sulfonic Acids / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D007166:Immunosuppressive Agents; D013451:Sulfonic Acids; C576986:morin-5'-sulfonic acid; C018524:N,N-dimethylarginine; D003520:Cyclophosphamide; D001120:Arginine; D000581:Amidohydrolases; C059999:dimethylargininase