title: MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases.
abstract: MicroRNAs (miRNAs) are a class of approximately 20-nucleotides single-stranded endogenous RNAs that regulate gene expression at the post-transcriptional level. miRNAs have recently been known to regulate cell proliferation, differentiation, and apoptosis. Fibrosis is the leading cause of organ dysfunction in diseases and results from an imbalance in the turnover of extracellular matrix components. Accumulating studies have demonstrated that miR-29 family participates in the development of liver fibrosis, renal fibrosis, pulmonary fibrosis, cardiac fibrosis. In this review, we are discussing the comprehensive role of miR-29 family in moderating profibrotic effect and its potential as therapeutic approach to fibrosis diseases.
authors.affiliation: School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Xiang
authors.initials: X
authors.lastname: Lin
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D005355:Fibrosis / Q000235:genetics / Q000628:therapy*; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics / Q000628:therapy; D008103:Liver Cirrhosis / Q000235:genetics / Q000628:therapy; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000235:genetics / Q000628:therapy
chemical_list: C532045:MIRN29a microRNA, human; D035683:MicroRNAs