title: Dronedarone and Captisol-enabled amiodarone in an experimental cardiac arrest.
abstract: OBJECTIVE
  To compare the energy required for defibrillation and postshock outcomes after the administration of dronedarone, amiodarone, and placebo in a porcine model of cardiac arrest.
  
  
  METHODS
  Forty-two pigs were randomized to amiodarone, dronedarone, or control treatments. After induction of ventricular fibrillation, compressions and ventilations were performed for 3 minutes and treatment was administered over 30 seconds. If defibrillation was unsuccessful, cardiopulmonary resuscitation continued and repeated shocks were administered every 2 minutes with continual hemodynamic monitoring for a total duration of 30 minutes.
  
  
  RESULTS
  The cumulative energy required for defibrillation was 570 ± 422 J for dronedarone, 441 ± 365 J for amiodarone, and 347 ± 281 J for control (P = not significant). Survival at 30 minutes was 1 (7.1%) for dronedarone compared with 11 (78.6%) for control (P = 0.001). Mortality in the dronedarone group was because of refibrillation in 3 (21.4%) cases, atrioventricular block in 1 (7.1%) case, and hypotension not because of bradycardia in 9 (64.3%) cases. Two minutes after successful defibrillation, systolic aortic pressure was lower in dronedarone versus control (86.6 ± 26.9 vs. 110 ± 15.1 mm Hg; P = 0.035).
  
  
  CONCLUSIONS
  The administration of dronedarone resulted in a significant reduction in survival and both systolic aortic and coronary perfusion pressure compared with control.
authors.affiliation: Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, Ontario, Canada.
authors.forename: Benedict M
authors.initials: BM
authors.lastname: Glover
authors.forename: Xudong
authors.initials: X
authors.lastname: Hu
authors.forename: Theresa
authors.initials: T
authors.lastname: Aves
authors.forename: Andrew
authors.initials: A
authors.lastname: Ramadeen
authors.forename: Lily
authors.initials: L
authors.lastname: Zou
authors.forename: Howard
authors.initials: H
authors.lastname: Leong-Poi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Fujii
authors.forename: Paul
authors.initials: P
authors.lastname: Dorian
mesh_terms: D000638:Amiodarone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D016887:Cardiopulmonary Resuscitation; D004195:Disease Models, Animal; D000077764:Dronedarone; D004554:Electric Countershock; D006323:Heart Arrest / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D013552:Swine; D014693:Ventricular Fibrillation
chemical_list: D000889:Anti-Arrhythmia Agents; D000077764:Dronedarone; D000638:Amiodarone