title: Enterobacter cloacae producing an uncommon class A carbapenemase, IMI-1, from Singapore.
abstract: In this study, we describe the characterization of an infrequently encountered class A carbapenemase, IMI-1, from a clinical Enterobacter cloacae isolate. The isolate had high levels of resistance to carbapenems but retained susceptibility to expanded-spectrum cephalosporins. The blaIMI-1 gene was chromosomally encoded. Detection of the IMI-1 producer highlights the diversity of carbapenemases in a local clinical setting.
authors.affiliation: Department of Laboratory Medicine, National University Hospital, Singapore 119074, Republic of Singapore.
authors.forename: Jeanette W P
authors.initials: JWP
authors.lastname: Teo
authors.affiliation: National Public Health Laboratory, Singapore 169612, Republic of Singapore.
authors.forename: My-Van
authors.initials: MV
authors.lastname: La
authors.affiliation: Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore 308433, Republic of Singapore.
authors.forename: Prabha
authors.initials: P
authors.lastname: Krishnan
authors.affiliation: Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore 308433, Republic of Singapore.
authors.forename: Brenda
authors.initials: B
authors.lastname: Ang
authors.affiliation: Department of Laboratory Medicine, National University Hospital, Singapore 119074, Republic of Singapore.
authors.forename: Roland
authors.initials: R
authors.lastname: Jureen
authors.affiliation: Department of Laboratory Medicine, National University Hospital, Singapore 119074, Republic of Singapore.
authors.forename: Raymond T P
authors.initials: RTP
authors.lastname: Lin
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D015780:Carbapenems / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012846:Singapore / Q000453:epidemiology; D001618:beta-Lactamases / Q000145:classification* / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase