title: Polysaccharide-lecithin reverse micelles with enzyme-degradable triglyceride shell for overcoming tumor multidrug resistance.
abstract: A newly-designed drug carrier with enzyme-triggered release behavior and the ability to circumvent multidrug resistance was successfully developed. By optimizing the ratio of lecithin and polysaccharide in reverse micelles, encapsulation efficiency and encapsulation stability can be significantly improved.
authors.affiliation: Department of Materials Sciences and Engineering, National Chiao Tung University, Hsinchu, 30010, Taiwan.
authors.forename: Chia-Wei
authors.initials: CW
authors.lastname: Su
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Chen
authors.forename: Dean-Mo
authors.initials: DM
authors.lastname: Liu
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry; D019008:Drug Resistance, Neoplasm; D006801:Humans; D006868:Hydrolysis; D054709:Lecithins / Q000737:chemistry*; D061986:MCF-7 Cells; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D002787:Sterol Esterase / Q000378:metabolism; D014280:Triglycerides / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D054709:Lecithins; D008823:Micelles; D011134:Polysaccharides; D014280:Triglycerides; D004317:Doxorubicin; D048271:Chitosan; D002787:Sterol Esterase