title: Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila.
abstract: Animals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is, sweetness). The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupcake), which is structurally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestinal and renal lumen. However, SLC5A11 was prominently expressed in 10-13 pairs of R4 neurons of the ellipsoid body in the brain and functioned in these neurons for selecting appropriate foods.
authors.affiliation: Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
authors.forename: Monica
authors.initials: M
authors.lastname: Dus
authors.forename: Minrong
authors.initials: M
authors.lastname: Ai
authors.forename: Greg S B
authors.initials: GS
authors.lastname: Suh
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D030801:Animals, Genetically Modified; D001483:Base Sequence; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D016827:CD8 Antigens / Q000235:genetics; D002755:Choice Behavior / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D005508:Food Deprivation / Q000502:physiology; D005518:Food Preferences / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D005947:Glucose / Q000008:administration & dosage; D006003:Glycogen / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000235:genetics; D006458:Hemolymph / Q000378:metabolism; D006801:Humans; D009154:Mutation / Q000235:genetics; D009474:Neurons / Q000378:metabolism; D034622:RNA Interference; D011956:Receptors, Cell Surface / Q000235:genetics; D051247:Sodium-Glucose Transport Proteins / Q000235:genetics / Q000378:metabolism*; D013649:Taste / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D016827:CD8 Antigens; D029721:Drosophila Proteins; C557617:GAL4 protein, Drosophila; D011956:Receptors, Cell Surface; C581906:SLC5A11 protein, Drosophila; D051247:Sodium-Glucose Transport Proteins; D014157:Transcription Factors; C405956:gustatory receptor, Drosophila; D049452:Green Fluorescent Proteins; D006003:Glycogen; D005947:Glucose
references.citation: Nature. 2010 Dec 2;468(7324):686-90
references.pmid: 21124455
references.citation: Diabetes. 2006 Dec;55(12):3381-6
references.pmid: 17130483
references.citation: Nature. 2008 Jun 26;453(7199):1244-7
references.pmid: 18509336
references.citation: J Neurobiol. 1999 Nov 5;41(2):189-207
references.pmid: 10512977
references.citation: Curr Biol. 2011 May 10;21(9):751-5
references.pmid: 21514154
references.citation: Development. 2002 Dec;129(24):5667-81
references.pmid: 12421707
references.citation: Proc Soc Exp Biol Med. 1950 Oct;75(1):77-80
references.pmid: 14797742
references.citation: Curr Biol. 2011 May 10;21(9):746-50
references.pmid: 21514159
references.citation: Science. 2003 Dec 5;302(5651):1765-8
references.pmid: 14657498
references.citation: Nature. 2006 Jan 26;439(7075):470-4
references.pmid: 16340960
references.citation: Nature. 2006 Jan 26;439(7075):475-9
references.pmid: 16340959
references.citation: Nature. 2011 Jun 08;474(7350):204-7
references.pmid: 21654803
references.citation: Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11644-9
references.pmid: 21709242
references.citation: Cell. 2002 May 17;109(4):485-95
references.pmid: 12086605
references.citation: J Neurosci. 2012 Oct 17;32(42):14767-74
references.pmid: 23077061
references.citation: Physiol Rev. 2011 Apr;91(2):733-94
references.pmid: 21527736
references.citation: Appetite. 2001 Feb;36(1):79-83
references.pmid: 11161347
references.citation: Neuron. 2008 Mar 27;57(6):930-41
references.pmid: 18367093