title: [Analysis of clinicopathologic characteristics and prognosis on mixed histology type of gastric cancer].
abstract: OBJECTIVE
  To evaluate the clinicopathologic characteristics and prognosis of mixed histological type (MHT) gastric cancer.
  
  
  METHODS
  Clinical and follow-up data of 1108 gastric cancer patients undergoing radical operation in Tianjin Cancer Hospital between 2003 and 2006 were analyzed retrospectively. Clinicopathologic characteristics of MHT gastric cancer were summarized and the prognosis was analyzed by Kaplan-Meier analysis and COX regression.
  
  
  RESULTS
  Among the 1108 patients, 144 (13.0%) had mixed histology type of gastric cancer. Compared to the unitary histological type (UHT), MHT gastric cancer had bigger tumor size, higher proportion of T4 tumor, and was easier for lymph node and distant metastasis (all P<0.05). The 3- and 5-year survival rates of patients with MHT were 26.5% and 10.8% respectively, which were lower than those with UHT (58.8% and 35.0%, P<0.01). Univariate and multivariate analyses showed TNM classification was an independent prognostic factor (P<0.01).
  
  
  CONCLUSIONS
  MHT gastric cancer shows worse prognosis than UHT gastric cancer. There is no difference in prognosis among various combination of MHT gastric cancer. TNM classification is an independent prognostic factor of MHT gastric cancer.
authors.affiliation: Department of Gastrointestinal Oncology Surgery, Key Lab of Cancer Treatment and Prevention, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China.
authors.forename: Xu-guang
authors.initials: XG
authors.lastname: Jiao
authors.forename: Han
authors.initials: H
authors.lastname: Liang
authors.forename: Jing-yu
authors.initials: JY
authors.lastname: Deng
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Hong-gen
authors.initials: HG
authors.lastname: Liu
authors.forename: Yue-xiang
authors.initials: YX
authors.lastname: Liang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018193:Neoplasms, Complex and Mixed / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D055815:Young Adult