title: Association of the interleukin-10 -592A/C, -1082G/A and -819T/C gene polymorphisms with type 2 diabetes: a meta-analysis.
abstract: There is more evidence that interleukin-10 (IL-10), as a multifunctional regulatory cytokine of inflammatory responses, may have an important role in type 2 diabetes (T2D). However, genetic association studies that evaluated the relationship between IL-10 gene variants and T2D have produced conflicting results. The aim of this study was to determine whether the IL-10 gene polymorphisms (-592A/C, -1082G/A, -819T/C) conferred susceptibility to T2D through a meta-analysis. A comprehensive search was conducted to examine all the eligible studies. A total of 9 studies involving 2838 T2D patients and 2773 controls were considered in the meta-analysis. Overall, there was no significant association between IL-10 -592A/C and T2D (A vs C: OR=0.93, P=0.625; AA+AC vs CC: OR=0.89, P=0.511; AA vs AC+CC: OR=0.93, P=0.821). We failed to find the association between the IL-10 -1082G allele and T2D (OR=1.04, P=0.430), but the genotypes of the IL-10 -1082G/A polymorphism conferred a risk for the development of T2D (GA vs AA: OR=1.21, P=0.027; GG+GA vs AA: OR=1.17, P=0.048). Analysis of the -819T/C polymorphism revealed no significant association with T2D (T vs C: OR=1.04, P=0.853; TT+TC vs CC: OR=1.07, P=0.834; TT vs TC+CC: OR=1.08, P=0.824). In conclusion, the present meta-analysis suggests association between the IL-10 -1082G/A polymorphism and T2D. However, additional well-designed and larger scale primary studies are required to further evaluate the IL-10 gene polymorphisms and T2D.
authors.affiliation: Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Song
authors.initials: S
authors.lastname: Wu
authors.forename: Ming-Rui
authors.initials: MR
authors.lastname: Wang
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wang
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10