title: The potential role of iodine-123 metaiodobenzylguanidine imaging for identifying sustained ventricular tachycardia in patients with cardiomyopathy.
abstract: Implantable cardioverter-defibrillators (ICDs) significantly reduce mortality in patients with depressed left ventricular ejection fraction (LVEF) and heart failure (HF). However, shortcomings of LVEF to accurately identify those at greatest risk of ventricular tachyarrhythmias have led to the pursuit of alternative means to refine qualification criteria for ICD implantation. It is well established that imaging the cardiac nervous system with(123)I meta-iodobenzylguanidine ((123)I-mIBG) provides incremental prognostic value in patients with HF beyond LVEF. Whether (123)I-mIBG will also play an important role for identifying and/or predicting sustained ventricular tachyarrhythmias in patients with cardiomyopathy and determining those who may benefit from ICD implantation is currently under investigation. Novel imaging approaches that pinpoint the site of ventricular arrhythmias and guide ventricular tachycardia ablation are presented.
authors.affiliation: Maryland Arrhythmia and Cardiology Imaging Group (MACIG), Department of Medicine, Division of Cardiology, University of Maryland Medical Center, 22 South Greene St, Baltimore, MD, 21201, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Klein
authors.forename: Vasken
authors.initials: V
authors.lastname: Dilsizian
authors.forename: Qi
authors.initials: Q
authors.lastname: Cao
authors.forename: Wengen
authors.initials: W
authors.lastname: Chen
authors.forename: Timm-Michael
authors.initials: TM
authors.lastname: Dickfeld
mesh_terms: D019797:3-Iodobenzylguanidine; D009202:Cardiomyopathies / Q000150:complications*; D017147:Defibrillators, Implantable; D006321:Heart / Q000294:innervation; D006801:Humans; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D017180:Tachycardia, Ventricular / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine
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