title: Radiolabeled heterobivalent peptidic ligands: an approach with high future potential for in vivo imaging and therapy of malignant diseases.
abstract: Two-pronged synergism: We review the recently developed approach of using heterobivalent peptide ligands that interact concomitantly with different receptors on tumor cells. These ligands exhibit highly favorable tumor-targeting properties and pave the way for the development of drugs for specific, sensitive, and noninvasive tumor imaging and therapy.
authors.affiliation: Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Fischer
authors.forename: Ralf
authors.initials: R
authors.lastname: Schirrmacher
authors.forename: Björn
authors.initials: B
authors.lastname: Wängler
authors.forename: Carmen
authors.initials: C
authors.lastname: Wängler
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging; D006801:Humans; D007553:Isotope Labeling; D008024:Ligands; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use*; D049268:Positron-Emission Tomography
chemical_list: D008024:Ligands; D010455:Peptides