title: Olive oil improves the intestinal absorption and bioavailability of lutein in lutein-deficient mice.
abstract: OBJECTIVE
  To investigate the influence of olive (OO), groundnut (GNO), soybean (SBO), sunflower (SFO), rice bran (RBO), corn (CO), palm (PO) oil or mixed micelle (control) on absorption kinetics and bioavailability of lutein in lutein-deficient mice. Additional aim was to correlate the activity of intestinal triacylglycerol lipase with intestinal and plasma lutein levels.
  
  
  METHODS
  After induction of lutein deficiency, mice (n = 165) were divided into eight groups (OO, SFO, GNO, RBO, PO, CO, SBO and control; n = 20/group) and the remaining (n = 5) were used as baseline (0 h). Groups were further divided into four subgroups (n = 5/subgroup) and were intubated with lutein (200 μM) dispersed in different vegetable oils. Plasma and tissue (intestine, liver and eyes), lutein, triglycerides, intestinal triacylglycerol lipases and fatty acid profile of plasma and tissues were measured at different time intervals.
  
  
  RESULTS
  The percentage area under the curve value for plasma lutein in OO and GNO was higher by 41.8 and 5.1 %, while it was lower in other groups (18.2-53.3 %), when compared to control. Similarly, the percentage area under the curve for eye lutein in OO and GNO groups was higher by 35.2 and 4.8 %, whereas in other groups it was lower (5.4-69 %) than in control. Results show that olive oil facilitates the lutein absorption more compared to other vegetable oils, which may be due to the difference in fatty acid composition and higher activity of intestinal triacylglycerol lipase.
  
  
  CONCLUSIONS
  Dietary olive oil rich in oleic acid improves the bioavailability and accumulation of lutein in lutein-deficient mice by modifying the intestinal triacylglycerol lipase activity.
authors.affiliation: Department of Biochemistry and Nutrition, CSIR-Central Food Technological Research Institute, Mysore, 570 020, Karnataka, India.
authors.forename: Bhatiwada
authors.initials: B
authors.lastname: Nidhi
authors.forename: Bangera Sheshappa
authors.initials: BS
authors.lastname: Mamatha
authors.forename: V
authors.initials: V
authors.lastname: Baskaran
mesh_terms: D000818:Animals; D010367:Arachis / Q000737:chemistry; D001682:Biological Availability; D003314:Corn Oil / Q000008:administration & dosage; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D005123:Eye / Q000187:drug effects / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D014975:Lutein / Q000097:blood / Q000172:deficiency* / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage*; D000073879:Rice Bran Oil; D013024:Soybean Oil / Q000008:administration & dosage; D000074242:Sunflower Oil; D014280:Triglycerides / Q000097:blood
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D013024:Soybean Oil; D003314:Corn Oil; D000073879:Rice Bran Oil; D014975:Lutein
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