title: Hepatic regeneration and the epithelial to mesenchymal transition.
abstract: Liver injuries are repaired by fibrosis and regeneration. The core stage is the repair response and fibrosis formation as a scar. The cause of overly-responsive scar formation and diminished regeneration, especially in liver fibrosis and cirrhosis, is still unknown. The epithelial to mesenchymal transition (EMT), a previously discovered mechanism, plays an important role in liver fibrosis and tumor metastasis. Recently, EMT has been found to be associated with liver and bile duct cell fibrosis. Analyzing the established models and chronic disease processes, we propose that EMT liver cells may also lose their regenerative capability due to phenotype changes and that the remaining liver cells may quickly lose their regenerative capability in liver fibrosis or cirrhosis. Recognizing these phenotype changes or transition cells may play an important role in targeting therapy to reverse fibrosis not only by disrupting the transition that is necessary to produce the extracellular matrix but also by restoring the regenerative capacity of EMT-like cells.
authors.affiliation: Department of Digestive Diseases, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China.
authors.forename: Zeng-Fu
authors.initials: ZF
authors.lastname: Xue
authors.forename: Xiu-Min
authors.initials: XM
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D058750:Epithelial-Mesenchymal Transition; D005109:Extracellular Matrix / Q000378:metabolism; D055166:Hepatic Stellate Cells / Q000378:metabolism / Q000473:pathology; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008103:Liver Cirrhosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008115:Liver Regeneration; D010641:Phenotype
keywords: Epithelial to mesenchymal transition; Epithelial to mesenchymal transition -like; Fibrosis; Hepatocyte; Hepatocyte stellate cells; Liver; Regeneration; Transforming growth factor-β
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