title: Pneumococcal diagnosis and serotypes in childhood community-acquired pneumonia.
abstract: The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced routinely in the UK from September 2006 and replaced by PCV13 in 2010. In a prospective study from 2009 to 2011 of 160 children aged ≤16 years with radiologically confirmed pneumonia, likely pneumococcal infections were identified in 26%. Detection of pneumococci was improved with polymerase chain reaction compared to culture (21.6% versus 6% of children tested, P = 0.0004). Where serotyping was possible, all (n = 23) were non-PCV7 but PCV13 serotypes; 1 (43.5%), 3 (21.7%), 7A/F, and 19A (17.4% each).
authors.affiliation: Department of Paediatric Infectious Disease and Immunology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK. mohamed.elemraid@ncl.ac.uk
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Elemraid
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Sails
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Thomas
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Rushton
authors.forename: John D
authors.initials: JD
authors.lastname: Perry
authors.forename: Gary J A
authors.initials: GJ
authors.lastname: Eltringham
authors.forename: David A
authors.initials: DA
authors.lastname: Spencer
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Eastham
authors.forename: Fiona
authors.initials: F
authors.lastname: Hampton
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Gennery
authors.forename: Julia E
authors.initials: JE
authors.lastname: Clark
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000175:diagnosis* / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000627:therapeutic use; D011018:Pneumonia, Pneumococcal / Q000175:diagnosis* / Q000276:immunology / Q000517:prevention & control; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000276:immunology / Q000302:isolation & purification*; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate