title: In vivo effects on the intestinal microflora of Physalis alkekengi var. francheti extracts.
abstract: This study aimed to investigate the effects on the intestinal microflora balance of Physalis alkekengi var. francheti extracts (PE) using in vivo mouse model. Luteolin-7-O-β-glycoside, Physalin J, Physalin D, and Physalin P were isolated from PE extracts and identified. Bacteroides, Lactobacillus, Helicobacter, Prevotella, Odoribacter and Oribacterium were detected as dominant organisms in the intestinal tract of mice by denaturing gradient gel electrophoresis (DGGE) analysis. The quality and quantity of Lactobacillus genus increased significantly with increasing concentration of PE. This study shows that the intestinal microflora balance could be improved by PE, and thus, it has the significant potential to be used as a natural agent for restoring the intestinal microflora balance.
authors.affiliation: Department of Biotechnology, Dalian Medical University, Dalian, China.
authors.forename: Xinli
authors.initials: X
authors.lastname: Li
authors.forename: Cuili
authors.initials: C
authors.lastname: Zhang
authors.forename: Weiling
authors.initials: W
authors.lastname: Li
authors.forename: Dachang
authors.initials: D
authors.lastname: Wu
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Tang
authors.forename: Yi
authors.initials: Y
authors.lastname: Xin
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007422:Intestines / Q000187:drug effects* / Q000382:microbiology; D007778:Lactobacillus / Q000187:drug effects*; D047311:Luteolin / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D064307:Microbiota / Q000187:drug effects*; D032321:Physalis / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D056692:Prebiotics; D012632:Secosteroids / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D056692:Prebiotics; D012632:Secosteroids; C441429:physalin D; D047311:Luteolin