title: Anodic aluminium oxide membranes for immunoisolation with sufficient oxygen supply for pancreatic islets.
abstract: Immunoisolation membranes have been developed for various cell encapsulations for therapeutic purposes. However effective encapsulation systems have been hindered by low oxygen (O2) permeability or imperfect immunoisolation caused by either low porosity or non-uniform pore geometry. Here, we report an encapsulation method that uses an anodic aluminum oxide membrane formed by polyethylene oxide self-assembly to obtain nanochannels with both high selectivity in excluding immune molecules and high permeability of nutrients such as glucose, insulin, and O2. The extracorporeal encapsulation system composed of these membranes allows O2 flux to meet the O2 demand of pancreatic islets of Langerhans and provides excellent in vitro viability and functionality of islets.
authors.affiliation: Dept. Mechanical Engineering POSTECH, San 31, Hyoja-dong, Nam-gu, Pohang, Gyoengbuk, Republic of Korea.
authors.forename: Siwoo
authors.initials: S
authors.lastname: Cho
authors.forename: Sangmin
authors.initials: S
authors.lastname: Lee
authors.forename: Seong Hee
authors.initials: SH
authors.lastname: Jeong
authors.forename: Yeongae
authors.initials: Y
authors.lastname: Kim
authors.forename: Song Cheol
authors.initials: SC
authors.lastname: Kim
authors.forename: Woonbong
authors.initials: W
authors.lastname: Hwang
authors.forename: Jaesung
authors.initials: J
authors.lastname: Park
mesh_terms: D000537:Aluminum Oxide / Q000494:pharmacology*; D000818:Animals; D002469:Cell Separation / Q000379:methods; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000166:cytology* / Q000378:metabolism; D016381:Islets of Langerhans Transplantation / Q000379:methods; D008567:Membranes, Artificial; D036103:Nanotechnology / Q000379:methods*; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007328:Insulin; D008567:Membranes, Artificial; D005947:Glucose; D000537:Aluminum Oxide; D010100:Oxygen