title: [First experience of the study "Intramyocardial Multiple Precision Administration of Mononuclear Bone Marrow Cells in the Treatment of Myocardial Ischemia"].
abstract: Study aim - to elucidate possibilities of the use of precision administration of mononuclear bone marrow cells (MBMC) for the treatment of myocardial ischemia and heart failure. "Intramyocardial Multiple Precision Administration of Mononuclear Bone Marrow Cells in the Treatment of Myocardial Ischemia" was a double blind randomized placebo controlled study in which we included patients more or equal 6 months after Q-wave myocardial infarction with systolic myocardial dysfunction (ejection fraction <35%), not requiring myocardial revascularization, receiving stable optimal medical therapy for more or equal 8 weeks, and with implanted cardioverter-defibrillator. Transplantation of MBMC was guided by fluoroscopy and tridimensional NOGA XP Cardiac Navigation System. For assessment of efficacy of the method we used surrogate end points: decrease of number of fixed perfusion defects according to SPECT data and improvement of regional myocardial contractility according to data of echocardiography. Results of dynamic observation of the first experience of MBMC administration are presented in this paper.
authors.forename: E V
authors.initials: EV
authors.lastname: Shliakhto
authors.forename: D S
authors.initials: DS
authors.lastname: Lebedev
authors.forename: D V
authors.initials: DV
authors.lastname: Kryzhanovskiĭ
authors.forename: S V
authors.initials: SV
authors.lastname: Anisimov
authors.forename: A V
authors.initials: AV
authors.lastname: Kozlenok
authors.forename: A V
authors.initials: AV
authors.lastname: Berezina
authors.forename: A A
authors.initials: AA
authors.lastname: Bilibina
authors.forename: D V
authors.initials: DV
authors.lastname: Motorin
authors.forename: G I
authors.initials: GI
authors.lastname: Petrenko
authors.forename: M V
authors.initials: MV
authors.lastname: Beliakova
authors.forename: E A
authors.initials: EA
authors.lastname: Beliakova
authors.forename: G G
authors.initials: GG
authors.lastname: Romanov
authors.forename: T V
authors.initials: TV
authors.lastname: Treshkur
authors.forename: O M
authors.initials: OM
authors.lastname: Moiseeva
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods*; D002317:Cardiovascular Agents / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006334:Heart Function Tests / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000150:complications*; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D015641:Radiography, Interventional / Q000379:methods; D013813:Therapy, Computer-Assisted / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents