title: Pyoderma gangrenosum associated with an aseptic splenic abscess in a patient with neurofibromatosis.
abstract: Pyoderma gangrenosum (PG) is a painful, ulcerating neutrophilic dermatosis commonly associated with a variety of underlying systemic conditions. We report a child with neurofibromatosis-1 (NF-1) and an aseptic splenic abscess who developed multifocal PG in areas of iatrogenic skin trauma. There is no clinical evidence or theoretical basis to suggest a causal relationship between NF-1 and PG. Systemic corticosteroid and cyclosporine therapy led to complete resolution of the lesions.
authors.affiliation: Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Jamie L
authors.initials: JL
authors.lastname: Johnson
authors.forename: Daniel A
authors.initials: DA
authors.lastname: West
authors.forename: Anita N
authors.initials: AN
authors.lastname: Haggstrom
mesh_terms: D000038:Abscess / Q000188:drug therapy / Q000209:etiology*; D002648:Child; D002990:Clobetasol / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000209:etiology*; D013158:Splenic Diseases / Q000188:drug therapy / Q000209:etiology*; D016559:Tacrolimus / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D002990:Clobetasol; D016559:Tacrolimus