title: Impossible or merely difficult? Two grand challenges from a biologist's perspective.
abstract: Here I propose two grand challenges for medicinal chemists: the deorphanization of orphan GPCRs viain silicomethods and the design of multi-target drugs with enhanced safety and efficacy over current medications.
authors.affiliation: Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Chapel Hill Medical School, 4072 Genetic Medicine Building, Chapel Hill, NC 27514.
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
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