title: Low expression of tyrosine-protein phosphatase nonreceptor type 12 is associated with lymph node metastasis and poor prognosis in operable triple-negative breast cancer.
abstract: BACKGROUND
  Low tyrosine-protein phosphatase nonreceptor type 12 (PTPN12) expression may be associated with breast cancer growth, proliferation, and metastasis. However, the prognostic value of PTPN12 in breast cancer has not been clearly identified.
  
  
  METHODS
  51 triple-negative breast cancer (TNBC) patients and 83 non-TNBC patients with a histopathology diagnosis from October 2001 to September 2006 were included in this study. Immunohistochemical staining for PTPN12 on tissue microarrays was conducted.
  
  
  RESULTS
  High PTPN12 expression was seen in 39.2% of TNBC and 60.2 % of non-TNBC cases. Low PTPN12 expression was associated with lymph node status (p = 0.002) and distant metastatic relapse (p = 0.002) in TNBC patients. Similarly, low PTPN12 expression in non-TNBC patients was significantly correlated with lymph node status (p = 0.002), stage (p = 0.002) and distant metastatic relapse (p = 0.039). The high PTPN12 expression group was associated with longer DFS and OS compared with low PTPN12 expression group only in TNBC cases (p = 0.005, p = 0.015), according to univariate Cox regression analysis.
  
  
  CONCLUSIONS
  These findings provide evidence that low expression of PTPN12 is associated with worse prognosis and may be used as a potential prognostic biomarker in TNBC patients.
authors.affiliation: Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.
authors.forename: Min-Qing
authors.initials: MQ
authors.lastname: Wu
authors.forename: Pan
authors.initials: P
authors.lastname: Hu
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Wei
authors.forename: Xiang-Sheng
authors.initials: XS
authors.lastname: Xiao
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Tang
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.forename: Qi-Dong
authors.initials: QD
authors.lastname: Ge
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jia
authors.forename: Ren-Bin
authors.initials: RB
authors.lastname: Liu
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Xie
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000556:secondary / Q000601:surgery; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000556:secondary / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D054594:Protein Tyrosine Phosphatase, Non-Receptor Type 12 / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D054594:Protein Tyrosine Phosphatase, Non-Receptor Type 12; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human; C516738:PTPN12 protein, human