title: Surgical removal of subfoveal choroidal neovascularization in pathologic myopia: a 12-year follow-up study.
abstract: The purpose of this study was to review the 12-year visual outcomes of patients who underwent surgical removal for subfoveal choroidal neovascularization (CNV) attributable to pathologic myopia. This retrospective study included 14 patients, with a mean age of 45.8 years, high myopia (>6 D) and classic subfoveal CNV. They were treated with pars plana vitrectomy and surgical removal of CNV. All patients were followed up every 3 months for 2 years, with visual acuity (VA), fundus examination, and fluorescein angiography and then every year for 5 years. Ten patients underwent a final visit with VA and fundus examination after a minimum 12-year follow-up. The main outcome measurement was VA and the secondary outcome measurement was the lesion size. After 12 years of follow-up, the mean VA did not significantly change over time, with a mean gain of 0.22 logMAR at 1 year, and 0.18, 0.12 and 0.05 at 2, 5 and 12 years, respectively. The anatomical evolution was characterized by a significant enlargement of the lesion size at 5 years. This study showed that final VA after surgical treatment with 12 years of follow-up was poor, due to the significant CNV scar enlargement over time. These results should prompt a prospective randomized study of other medical treatments, particularly anti-vascular endothelial growth factor therapy.
authors.affiliation: Department of Ophthalmology, University Hospital of Grenoble, Joseph Fourier University, Grenoble 1, 38041, Grenoble, France, ruxhp@yahoo.fr.
authors.forename: R
authors.initials: R
authors.lastname: Hera
authors.forename: C
authors.initials: C
authors.lastname: Chiquet
authors.forename: J P
authors.initials: JP
authors.lastname: Romanet
mesh_terms: D000328:Adult; D020256:Choroidal Neovascularization / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000150:complications* / Q000473:pathology; D012008:Recurrence; D012189:Retrospective Studies; D014792:Visual Acuity
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