title: Genotoxic assessment of carbon nanotubes.
abstract: Carbon nanotubes are unique one-dimensional macromolecules with promising application in biology and medicine. Since their toxicity is still under debate, here we describe an investigation of genotoxic properties of purified single-walled carbon nanotubes (SWCNT), multiwall carbon nanotubes (MWCNT), and amide-functionalized purified SWCNT. We used two different cell systems: cultured human lymphocytes where we employed cytokinesis-block micronucleus test and human fibroblasts where we investigate the induction of DNA double-strand breaks (DSBs) employing H2AX phosphorylation assay.
authors.affiliation: Institute of Nuclear Sciences Vinča, University of Belgrade, Belgrade, Serbia.
authors.forename: Olivera
authors.initials: O
authors.lastname: Nešković
authors.forename: Gordana
authors.initials: G
authors.lastname: Joksić
authors.forename: Ana
authors.initials: A
authors.lastname: Valenta-Šobot
authors.forename: Jelena
authors.initials: J
authors.lastname: Cvetićanin
authors.forename: Djordje
authors.initials: D
authors.lastname: Trpkov
authors.forename: Andreja
authors.initials: A
authors.lastname: Leskovac
authors.forename: Sandra
authors.initials: S
authors.lastname: Petrović
mesh_terms: D002460:Cell Line; D006801:Humans; D009152:Mutagenicity Tests; D037742:Nanotubes, Carbon / Q000633:toxicity*
chemical_list: D037742:Nanotubes, Carbon