title: Height gain at adult-height age in 184 short patients treated with growth hormone from prepubertal age to near adult-height age is not related to GH secretory status at GH therapy onset.
abstract: BACKGROUND
  GH release after stimuli classifies short children as severe idiopathic isolated GH deficiency (IIGHD), mild IIGHD, dissociated GH release (DGHR) and normal GH release (NGHR) and anthropometric birth data as adequate for gestational age (AGA) or small for gestational age (SGA). GH release after stimuli classifies AGA patients as IIGHD or as idiopathic short stature (ISS).
  
  
  OBJECTIVE
  To compare height gain induced by GH therapy (31.8 ± 3.5 µg/kg/day, 7.7 ± 1.6 years) started at prepubertal age and stopped at near adult-height age.
  
  
  METHODS
  A retrospective longitudinal multicenter study including 184 short patients classified as severe IIGHD n = 25, mild IIGHD n = 75, DGHR n = 55 and NGHR n = 29; or as IIGHD n = 78, ISS n = 57 and SGA n = 49. Height gain was evaluated throughout GH therapy and at adult-height age.
  
  
  RESULTS
  Height-SDS gain at adult-height age was similar among severe IIGHD (1.8 ± 0.8 SDS), mild IIGHD (1.6 ± 0.6 SDS), DGHR (1.7 ± 0.7 SDS) and NGHR (1.6 ± 0.7 SDS), or among IIGHD (1.7 ± 0.7 SDS), ISS (1.7 ± 0.6 SDS) and SGA (1.6 ± 0.8 SD).
  
  
  CONCLUSIONS
  GH-release stimuli are of little help for deciding on GH therapy in the clinical management of prepubertal children with IIGHD, ISS or SGA.
authors.affiliation: Department of Pediatrics, Institut de Recerca, Hospital Vall d'Hebron, Centre for Biomedical Research on Rare Diseases (CIBERER), Autonomous University, Barcelona, Spain. ancarrascosa@vhebron.net
authors.forename: A
authors.initials: A
authors.lastname: Carrascosa
authors.forename: L
authors.initials: L
authors.lastname: Audí
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Cancio
authors.forename: D
authors.initials: D
authors.lastname: Yeste
authors.forename: M
authors.initials: M
authors.lastname: Gussinye
authors.forename: A
authors.initials: A
authors.lastname: Campos
authors.forename: M A
authors.initials: MA
authors.lastname: Albisu
authors.forename: M
authors.initials: M
authors.lastname: Clemente
authors.forename: J
authors.initials: J
authors.lastname: Bel
authors.forename: R
authors.initials: R
authors.lastname: Nosás
authors.forename: M
authors.initials: M
authors.lastname: Rabanal
authors.forename: C
authors.initials: C
authors.lastname: Del Pozo
authors.forename: J M
authors.initials: JM
authors.lastname: Gómez
authors.forename: J
authors.initials: J
authors.lastname: Mesa
mesh_terms: D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000627:therapeutic use*; D019382:Human Growth Hormone / Q000172:deficiency / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000254:growth & development; D008137:Longitudinal Studies; D008297:Male; D011627:Puberty / Q000502:physiology; D012189:Retrospective Studies
chemical_list: D019382:Human Growth Hormone; D013006:Growth Hormone