title: A better mild traumatic brain injury model in the rat.
abstract: The primary pathology associated with mild -traumatic brain injury (TBI) is selective axonal injury, which may characterize the vast majority of blast-induced TBIs. Axonal injuries in cases of mild TBI have been considered to be the main factors responsible for the long-lasting memory or attentional impairment in affected subjects. Among these axonal injuries, recent attention has been focused on the cingulum bundle (CB). Furthermore, recent studies with diffusion tensor MR imaging have shown the presence of injuries of the CB in cases of mild TBI in humans. This study aimed to provide a better laboratory model of mild TBI.Sprague-Dawley rats were subjected to mild TBI using laser-induced shock waves (LISW) (sham, 0.5 J/cm(2), or 1.0 J/cm(2); n = 4 per group). Bodian-stained brain sections 14 days after LISW at 0.5 J/cm(2) or 1.0 J/cm(2) showed a decrease in the CB axonal density compared with the sham group, whereas there were no differences in the axonal density of the corpus callosum.The present study shows that this model is capable of reproducing the histological changes associated with mild TBI.
authors.affiliation: Department of Neurosurgery, National Defense Medical College, Saitama, Japan. s.takeuchi@room.ocn.ne.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nawashiro
authors.forename: Shunichi
authors.initials: S
authors.lastname: Sato
authors.forename: Satoko
authors.initials: S
authors.lastname: Kawauchi
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Nagatani
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Otani
authors.forename: Hideo
authors.initials: H
authors.lastname: Osada
authors.forename: Kojiro
authors.initials: K
authors.lastname: Wada
authors.forename: Katsuji
authors.initials: K
authors.lastname: Shima
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000209:etiology / Q000473:pathology*; D004195:Disease Models, Animal; D007834:Lasers / Q000009:adverse effects; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley