title: TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis.
abstract: BACKGROUND
  Psoriasis is a common multi-factorial skin disease, in which gene-gene and gene-environment interactions may affect the onset, manifestation and clinical course.
  
  
  OBJECTIVE
  To investigate the underlying gene-environment interaction among several established susceptibility genes, cigarette smoking and alcohol intake.
  
  
  METHODS
  Using a two-stage case-control design, we searched for pairwise interactions between cigarette smoking and alcohol intake respectively with 9 single nucleotide polymorphisms (SNPs) at ERAP1, PTTG1, CSMD1, GJB2, SERPINB8, ZNF816A and TNIP1/ANXA6 that have been associated with risk for psoriasis in 7,223 subjects. Multiple logistic regression analysis was used for data analysis.
  
  
  RESULTS
  Significant interactions were found for alcohol intake with rs3762999 (p=0.0257) and rs999556 (p=0.0071) at TNIP/ANXA6; and for cigarette smoking with rs7007032 (p=0.0023) and rs10088247 (p=0.0023) at CSMD1.
  
  
  CONCLUSIONS
  This study provides empirical evidence for the gene-environment interactions between TNIP1/ANXA6 and alcohol use, CSMD1 and cigarette smoking, highlighting the importance of gene-environment interactions in the pathogenesis of psoriasis.
authors.affiliation: Institute of Dermatology, Anhui Medical University, Hefei 230032, China.
authors.forename: Xian-yong
authors.initials: XY
authors.lastname: Yin
authors.forename: Hui
authors.initials: H
authors.lastname: Cheng
authors.forename: Wen-ju
authors.initials: WJ
authors.lastname: Wang
authors.forename: Wen-jun
authors.initials: WJ
authors.lastname: Wang
authors.forename: Hong-yang
authors.initials: HY
authors.lastname: Fu
authors.forename: Ling-hua
authors.initials: LH
authors.lastname: Liu
authors.forename: Feng-yu
authors.initials: FY
authors.lastname: Zhang
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: Xue-jun
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects / Q000235:genetics*; D017317:Annexin A6 / Q000235:genetics*; D016022:Case-Control Studies; D000072259:Connexin 26; D017630:Connexins; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D016015:Logistic Models; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011565:Psoriasis / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000235:genetics*; D025521:Tumor Suppressor Proteins
chemical_list: D017317:Annexin A6; C477880:CSMD1 protein, human; D017630:Connexins; D004268:DNA-Binding Proteins; C000607042:GJB2 protein, human; D008565:Membrane Proteins; C117046:TNIP1 protein, human; D025521:Tumor Suppressor Proteins; D000072259:Connexin 26