title: Methyl - aminolevulinic acid photodynamic therapy and topical tretinoin in a patient with vulvar extramammary Paget's disease.
abstract: Extramammary Paget's disease is a rare neoplasm of apocrine gland-bearing areas of the skin. The most common site of presentation is the vulva. Surgery is the most frequently reported therapy so far; however, it is invasive and it is complicated by a high rate of recurrence. For this reason, several less-invasive treatments have been recently proposed, including photodynamic therapy. We describe in this article the case of an 84-year-old patient with a noninvasive vulvar extramammary Paget's disease successfully treated with methyl-aminolevulinic acid photodynamic therapy associated with topical tretinoin.
authors.affiliation: Department of Internal Medicine, Geriatrics and Nephrology, Division of Dermatology, University of Bologna, Bologna, Italy. michela_magnano@virgilio.it
authors.forename: Michela
authors.initials: M
authors.lastname: Magnano
authors.forename: Camilla
authors.initials: C
authors.lastname: Loi
authors.forename: Federico
authors.initials: F
authors.lastname: Bardazzi
authors.forename: Elena Cleopatra
authors.initials: EC
authors.lastname: Burtica
authors.forename: Annalisa
authors.initials: A
authors.lastname: Patrizi
mesh_terms: D000279:Administration, Cutaneous; D000369:Aged, 80 and over; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010145:Paget Disease, Extramammary / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*; D014846:Vulvar Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D014212:Tretinoin; C475457:methyl 5-aminolevulinate; D000622:Aminolevulinic Acid