title: Investigation of basal cell carcinoma using dynamic focus optical coherence tomography.
abstract: Optical coherence tomography (OCT) is becoming a popular modality for skin tumor diagnosis and assessment of tumor size and margin status. We conducted a number of imaging experiments on periocular basal cell carcinoma (BCC) specimens using an OCT configuration. This configuration employs a dynamic focus (DF) procedure where the coherence gate moves synchronously with the peak of the confocal gate, which ensures better signal strength and preservation of transversal resolution from all depths. A DF-OCT configuration is used to illustrate morphological differences between the BCC and its surrounding healthy skin in OCT images. The OCT images are correlated with the corresponding histology images. To the best of our knowledge, this is the first paper to look at DF-OCT imaging in examining periocular BCC.
authors.affiliation: Research and Development Centre, School of Biosciences, University of Kent, Canterbury, Kent, UK. mrn.avanaki@seas.wustl.edu
authors.forename: Mohammad R N
authors.initials: MR
authors.lastname: Avanaki
authors.forename: Ali
authors.initials: A
authors.lastname: Hojjatoleslami
authors.forename: Mano
authors.initials: M
authors.lastname: Sira
authors.forename: John B
authors.initials: JB
authors.lastname: Schofield
authors.forename: Carole
authors.initials: C
authors.lastname: Jones
authors.forename: Adrian Gh
authors.initials: AG
authors.lastname: Podoleanu
mesh_terms: D002280:Basal Cell Carcinoma / Q000473:pathology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D007909:Lenses; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*