title: Association between ozone exposure and onset of stroke in Allegheny County, Pennsylvania, USA, 1994-2000.
abstract: BACKGROUND
  Epidemiological studies have shown adverse short-term effects of air pollution on health including cardiovascular morbidity and mortality. However, air pollution-related stroke has received less attention.
  
  
  METHODS
  In this study, we performed a time-stratified case-crossover analysis to evaluate the relationships between stroke hospital admissions and O3, among patients aged 65 years and older in Allegheny County, Pa., USA, between 1994 and 2000. We also examined whether the effects of air pollutants differed across strata defined by patient demographic characteristics and ambient temperature.
  
  
  RESULTS
  Exposures to O3 on the current day increase the risk of total stroke hospitalization by 1.9% (95% CI: 0.01-3.8) per interquartile range increase in concentration. Furthermore, the results suggest that males were more sensitive to adverse health effects of O3 on stroke hospitalization than females.
  
  
  CONCLUSIONS
  These results suggest that O3 has an adverse effect on stroke hospitalization. Specific patient subgroups, such as males, may be at increased risk.
authors.affiliation: Department of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, Fla. 32610, USA. xhxu@phhp.ufl.edu
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Xu
authors.forename: Yilun
authors.initials: Y
authors.lastname: Sun
authors.forename: Sandie
authors.initials: S
authors.lastname: Ha
authors.forename: Evelyn O
authors.initials: EO
authors.lastname: Talbott
authors.forename: Claudia T K
authors.initials: CT
authors.lastname: Lissaker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000009:adverse effects / Q000032:analysis; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D010126:Ozone / Q000009:adverse effects* / Q000032:analysis; D010414:Pennsylvania / Q000453:epidemiology; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology
chemical_list: D000393:Air Pollutants; D010126:Ozone