title: Cullin' PLK1 from kinetochores.
abstract: To ensure proper attachment of all chromosomes to the spindle, PLK1 has to associate with kinetochores during prometaphase and must be released from these sites before sister chromatid separation can begin. The monoubiquitylation of PLK1 by the ubiquitin ligase CUL3-KLHL22 is now identified as a critical step in promoting the release of PLK1 from kinetochores, pushing non-proteolytic ubiquitylation into the limelight of cell division research.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
authors.forename: Colleen A
authors.initials: CA
authors.lastname: McGourty
authors.forename: Michael
authors.initials: M
authors.lastname: Rape
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism*; D018385:Centrosome / Q000378:metabolism*; D002877:Chromosomes, Human / Q000235:genetics*; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*; D000097869:Polo-Like Kinase 1
chemical_list: D018797:Cell Cycle Proteins; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1
references.citation: Nature. 2012 Feb 22;482(7386):495-500
references.pmid: 22358839
references.citation: Nat Cell Biol. 2013 Apr;15(4):430-9
references.pmid: 23455478
references.citation: Nat Genet. 2004 Nov;36(11):1159-61
references.pmid: 15475955
references.citation: Genes Dev. 2007 Sep 1;21(17):2205-19
references.pmid: 17785528
references.citation: Mol Cell Proteomics. 2011 Oct;10(10):M111.013284
references.pmid: 21890473
references.citation: Mol Cell. 2013 Feb 21;49(4):591-600
references.pmid: 23438855
references.citation: J Cell Biol. 2012 Aug 20;198(4):491-9
references.pmid: 22908307
references.citation: Cell. 2003 Oct 3;115(1):83-95
references.pmid: 14532005
references.citation: Dev Cell. 2012 Oct 16;23(4):745-55
references.pmid: 23079597
references.citation: J Cell Biol. 2010 Mar 22;188(6):809-20
references.pmid: 20231380
references.citation: Mol Cell. 2011 Oct 21;44(2):325-40
references.pmid: 21906983
references.citation: Science. 2003 Feb 21;299(5610):1228-31
references.pmid: 12595692
references.citation: J Cell Biol. 2009 Dec 14;187(6):791-800
references.pmid: 19995937
references.citation: Nat Rev Cancer. 2010 Dec;10(12):825-41
references.pmid: 21102634
references.citation: Nat Rev Mol Cell Biol. 2007 May;8(5):379-93
references.pmid: 17426725