title: Resting heart rate: its correlations and potential for screening metabolic dysfunctions in adolescents.
abstract: BACKGROUND
  In pediatric populations, the use of resting heart rate as a health index remains unclear, mainly in epidemiological settings. The aims of this study were to analyze the impact of resting heart rate on screening dyslipidemia and high blood glucose and also to identify its significance in pediatric populations.
  
  
  METHODS
  The sample was composed of 971 randomly selected adolescents aged 11 to 17 years (410 boys and 561 girls). Resting heart rate was measured with oscillometric devices using two types of cuffs according to the arm circumference. Biochemical parameters triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and glucose were measured. Body fatness, sleep, smoking, alcohol consumption and cardiorespiratory fitness were analyzed.
  
  
  RESULTS
  Resting heart rate was positively related to higher sleep quality (β = 0.005, p = 0.039) and negatively related to cardiorespiratory fitness (β = -0.207, p = 0.001). The receiver operating characteristic curve indicated significant potential for resting heart rate in the screening of adolescents at increased values of fasting glucose (area under curve = 0.611 ± 0.039 [0.534 - 0.688]) and triglycerides (area under curve = 0.618 ± 0.044 [0.531 - 0.705]).
  
  
  CONCLUSIONS
  High resting heart rate constitutes a significant and independent risk related to dyslipidemia and high blood glucose in pediatric populations. Sleep and cardiorespiratory fitness are two important determinants of the resting heart rate.
authors.forename: Rômulo A
authors.initials: RA
authors.lastname: Fernandes
authors.forename: Enio R
authors.initials: ER
authors.lastname: Vaz Ronque
authors.forename: Danielle
authors.initials: D
authors.lastname: Venturini
authors.forename: Décio S
authors.initials: DS
authors.lastname: Barbosa
authors.forename: Danilo P
authors.initials: DP
authors.lastname: Silva
authors.forename: Crisieli T
authors.initials: CT
authors.lastname: Cogo
authors.forename: Mariana Souza
authors.initials: MS
authors.lastname: Carnelossi
authors.forename: Mariana B
authors.initials: MB
authors.lastname: Batista
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Coelho-E-Silva
authors.forename: Luís B
authors.initials: LB
authors.lastname: Sardinha
authors.forename: Edilson S
authors.initials: ES
authors.lastname: Cyrino
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008403:Mass Screening / Q000379:methods*; D010809:Physical Fitness; D015995:Prevalence; D012146:Rest / Q000502:physiology*; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
references.citation: Eur J Appl Physiol Occup Physiol. 1982;49(1):1-12
references.pmid: 7201922
references.citation: BMC Pediatr. 2012 Jan 12;12:5
references.pmid: 22239980
references.citation: Sleep Med Rev. 2010 Jun;14(3):191-203
references.pmid: 19932976
references.citation: Arq Bras Cardiol. 2011 Oct;97(4):317-23
references.pmid: 21830000
references.citation: Eur J Appl Physiol. 2008 Oct;104(3):557-65
references.pmid: 18597107
references.citation: Arq Bras Cardiol. 2005 Dec;85 Suppl 6:4-36
references.pmid: 16597097
references.citation: Physiol Rev. 2008 Jul;88(3):1009-86
references.pmid: 18626066
references.citation: J Hum Hypertens. 2002 May;16(5):327-32
references.pmid: 12082493
references.citation: Circ J. 2010 May;74(5):827-35
references.pmid: 20424336
references.citation: Hypertens Res. 2011 Apr;34(4):407-12
references.pmid: 21346766
references.citation: Hypertens Res. 2010 Sep;33(9):926-31
references.pmid: 20574424
references.citation: PLoS One. 2012;7(7):e41889
references.pmid: 22860025
references.citation: Hypertension. 2011 Nov;58(5):745-50
references.pmid: 21896939
references.citation: Hypertens Res. 2011 Aug;34(8):963-7
references.pmid: 21614004
references.citation: Arq Bras Cardiol. 2011 Jun;96(6):465-70
references.pmid: 21537530
references.citation: Eur J Pediatr. 2009 Nov;168(11):1349-54
references.pmid: 19221789
references.citation: Saudi Med J. 2009 Jul;30(7):926-31
references.pmid: 19618009
references.citation: J Pediatr. 2011 Apr;158(4):634-7
references.pmid: 21095617
references.citation: J Sleep Res. 2009 Jun;18(2):145-7
references.pmid: 19645959
references.citation: J Sleep Res. 2009 Jun;18(2):148-58
references.pmid: 19645960
references.citation: Med Sci Sports Exerc. 2001 Feb;33(2):270-4
references.pmid: 11224817
references.citation: Obes Res. 2000 Jan;8(1):12-9
references.pmid: 10678254
references.citation: Med Sci Sports Exerc. 2002 Apr;34(4):689-94
references.pmid: 11932580
references.citation: Am J Clin Nutr. 1982 Nov;36(5):936-42
references.pmid: 7137077
references.citation: J Hypertens. 2011 Nov;29(11):2075-83
references.pmid: 21970936
references.citation: Circulation. 1999 Mar 23;99(11):1471-6
references.pmid: 10086972
references.citation: Am J Cardiol. 2012 Mar 1;109(5):685-92
references.pmid: 22169130
references.citation: J Sports Sci. 1988 Summer;6(2):93-101
references.pmid: 3184250
references.citation: Prev Chronic Dis. 2012;9:E104
references.pmid: 22632741