title: Antioxidant, antibacterial activity and brine shrimp toxicity test of some mountainous lichens from Nepal.
abstract: A total of twenty four lichen species belonging to six families were collected from mountainous region of Nepal. The methanol extracts of each species were tested for antimicrobial and antioxidant activities in vitro. It was found that extracts of twenty one lichen species were active against B. subtilis and seven species were active against S. aureus. Similarly, in DPPH assay, three species Peltigera sp.,Cladonia sp., and Canoparmelia sp. showed comparable activity with commercial standard, BHA. In ABTS+ assay, extracts of Parmoterma sp., Ramalina sp., Peltigera sp. and Cladonia sp. showed stronger activity than ascorbic acid. The observed data after comparison with previously published reports indicated that the high altitude lichens contain stronger antioxidant and antibacterial constituents. Similarly, the methanol extracts of Heterodermia sp. and Ramalina sp. showed comparable toxicity effect with commercial standard berberine chloride indicating a potent source of anticancer drugs.
authors.affiliation: Division of LifeSciences, Korea Polar Research Institute, KOPRI, Songdo Technopark, Songdo-dong 7-50, Yeonsu-gu, Incheon 406-840, South Korea.
authors.forename: Babita
authors.initials: B
authors.lastname: Paudel
authors.forename: Hari
authors.initials: H
authors.lastname: Datta Bhattarai
authors.forename: Durga
authors.initials: D
authors.lastname: Prasad Pandey
authors.forename: Jae
authors.initials: J
authors.lastname: Seoun Hur
authors.forename: Soon
authors.initials: S
authors.lastname: Gyu Hong
authors.forename: Il-Chan
authors.initials: IC
authors.lastname: Kim
authors.forename: Joung
authors.initials: J
authors.lastname: Han Yim
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects*; D052978:Disk Diffusion Antimicrobial Tests; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008011:Lichens / Q000737:chemistry* / Q000145:classification; D009390:Nepal; D018675:Toxicity Tests / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants