title: Respiratory triggered 4D cone-beam computed tomography: a novel method to reduce imaging dose.
abstract: OBJECTIVE
  A novel method called respiratory triggered 4D cone-beam computed tomography (RT 4D CBCT) is described whereby imaging dose can be reduced without degrading image quality. RT 4D CBCT utilizes a respiratory signal to trigger projections such that only a single projection is assigned to a given respiratory bin for each breathing cycle. In contrast, commercial 4D CBCT does not actively use the respiratory signal to minimize image dose.
  
  
  METHODS
  To compare RT 4D CBCT with conventional 4D CBCT, 3600 CBCT projections of a thorax phantom were gathered and reconstructed to generate a ground truth CBCT dataset. Simulation pairs of conventional 4D CBCT acquisitions and RT 4D CBCT acquisitions were developed assuming a sinusoidal respiratory signal which governs the selection of projections from the pool of 3600 original projections. The RT 4D CBCT acquisition triggers a single projection when the respiratory signal enters a desired acquisition bin; the conventional acquisition does not use a respiratory trigger and projections are acquired at a constant frequency. Acquisition parameters studied were breathing period, acquisition time, and imager frequency. The performance of RT 4D CBCT using phase based and displacement based sorting was also studied. Image quality was quantified by calculating difference images of the test dataset from the ground truth dataset. Imaging dose was calculated by counting projections.
  
  
  RESULTS
  Using phase based sorting RT 4D CBCT results in 47% less imaging dose on average compared to conventional 4D CBCT. Image quality differences were less than 4% at worst. Using displacement based sorting RT 4D CBCT results in 57% less imaging dose on average, than conventional 4D CBCT methods; however, image quality was 26% worse with RT 4D CBCT.
  
  
  CONCLUSIONS
  Simulation studies have shown that RT 4D CBCT reduces imaging dose while maintaining comparable image quality for phase based 4D CBCT; image quality is degraded for displacement based RT 4D CBCT in its current implementation.
authors.affiliation: Radiation Physics Laboratory, Sydney Medical School, University of Sydney, NSW 2006, Australia.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Cooper
authors.forename: Ricky T
authors.initials: RT
authors.lastname: O'Brien
authors.forename: Salim
authors.initials: S
authors.lastname: Balik
authors.forename: Geoffrey D
authors.initials: GD
authors.lastname: Hugo
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Keall
mesh_terms: D001822:Body Burden; D003198:Computer Simulation; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D056973:Four-Dimensional Computed Tomography / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D015656:Respiratory Mechanics; D055425:Respiratory-Gated Imaging Techniques / Q000379:methods*; D012680:Sensitivity and Specificity
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