title: Cellular actions of nesfatin-1 on hypothalamic and medullary neurons.
abstract: The present review summarizes the current understanding of the neuronal activation patterns induced by nesfatin-1 in both the hypothalamus and the brainstem, as well as the physiological outcomes caused by the activation of these neuronal populations. Studies using cFos measurements, Ca(2+) imaging techniques, electrophysiological recordings, and microinjections have led to the identification of the paraventricular nucleus, arcuate nucleus, lateral and ventromedial hypothalamic areas, as well as medullary centers such as the nucleus of the solitary tract and dorsal motor nucleus of the vagus as targets of central nesfatin-1 actions on food intake, cardiovascular function, stress responses, and glucose homeostasis.
authors.affiliation: Queen's University, Department of Biomedical and Molecular Sciences, Kingston, Ontario, Canada, K7L 3N6. avf@queensu.ca.
authors.forename: Andrea
authors.initials: A
authors.lastname: Mimee
authors.forename: Alastair V
authors.initials: AV
authors.lastname: Ferguson
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology*; D008526:Medulla Oblongata / Q000166:cytology / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology*; D000080866:Nucleobindins; D015398:Signal Transduction
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins