title: Development and Aging of the Kisspeptin-GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?
abstract: The prominent role of the G protein coupled receptor GPR54 and its peptide ligand kisspeptin in the progression of puberty has been extensively documented in many mammalian species including humans. Kisspeptins are very potent gonadotropin-releasing hormone secretagogues produced by two main populations of neurons located in two ventral forebrain regions, the preoptic area and the arcuate nucleus. Within the last 2 years a substantial amount of data has accumulated concerning the development of these neuronal populations and their timely regulation by central and peripheral factors during fetal, neonatal, and peripubertal stages of development. This review focuses on the development of the kisspeptin-GPR54 system in the brain of female mice, rats, sheep, monkeys, and humans. We will also discuss the notion that this system represents a major target through which signals from the environment early in life can reprogram reproductive function.
authors.affiliation: UMR85 Physiologie de la Reproduction et des Comportements, Institut National de Recherche Agronomique Nouzilly, France ; UMR7247, Centre National de la Recherche Scientifique Nouzilly, France ; Université François Rabelais de Tours Tours, France ; Institut Français du Cheval et de l'Equitation Nouzilly, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Franceschini
authors.forename: Elodie
authors.initials: E
authors.lastname: Desroziers
keywords: GPR54; differentiation; environment; kisspeptin; neuron; ontogenesis; regulation; reproduction
references.citation: J Toxicol Environ Health B Crit Rev. 2011;14(5-7):449-72
references.pmid: 21790321
references.citation: Reprod Fertil Dev. 1995;7(5):1025-35
references.pmid: 8848567
references.citation: Neurosci Lett. 2009 Aug 28;460(2):143-7
references.pmid: 19477231
references.citation: N Engl J Med. 2003 Oct 23;349(17):1614-27
references.pmid: 14573733
references.citation: Front Endocrinol (Lausanne). 2011 Dec 01;2:80
references.pmid: 22654828
references.citation: Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E202-10
references.pmid: 21045176
references.citation: Biochem Biophys Res Commun. 2003 Dec 26;312(4):1357-63
references.pmid: 14652023
references.citation: J Neuroendocrinol. 2009 Jun;21(6):527-37
references.pmid: 19500223
references.citation: J Neurosci. 2007 Aug 15;27(33):8826-35
references.pmid: 17699664
references.citation: J Neurosci. 2008 Aug 27;28(35):8691-7
references.pmid: 18753370
references.citation: J Neurosci. 2012 Aug 15;32(33):11486-94
references.pmid: 22895731
references.citation: Endocrinology. 1987 Jul;121(1):347-51
references.pmid: 3297644
references.citation: Endocrinology. 2012 Sep;153(9):4422-31
references.pmid: 22733968
references.citation: Front Neuroendocrinol. 2013 Jan;34(1):3-17
references.pmid: 22728025
references.citation: J Comp Neurol. 2011 Oct 15;519(15):2954-77
references.pmid: 21484804
references.citation: Brain Res. 2010 Dec 10;1364:90-102
references.pmid: 20858464
references.citation: Mol Cell Endocrinol. 2010 Aug 5;324(1-2):3-11
references.pmid: 20005919
references.citation: J Neuroendocrinol. 2006 Apr;18(4):298-303
references.pmid: 16503925
references.citation: Neurotoxicology. 2009 May;30(3):350-7
references.pmid: 19442818
references.citation: Endocrinology. 2012 Mar;153(3):1352-63
references.pmid: 22275511
references.citation: Biochem Biophys Res Commun. 2004 Jul 23;320(2):383-8
references.pmid: 15219839
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22693-8
references.pmid: 21149719
references.citation: Endocrinology. 2010 Feb;151(2):722-30
references.pmid: 19952274
references.citation: Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1761-6
references.pmid: 15665093
references.citation: Neurosci Lett. 2012 Nov 30;531(1):40-5
references.pmid: 23069671
references.citation: Endocrinology. 2012 Apr;153(4):1887-97
references.pmid: 22315444
references.citation: Endocrinology. 2006 Dec;147(12):5817-25
references.pmid: 16959837
references.citation: Biol Reprod. 2009 Dec;81(6):1216-25
references.pmid: 19684332
references.citation: Endocrinology. 2012 Oct;153(10):4883-93
references.pmid: 22893725
references.citation: Biol Reprod. 2007 Sep;77(3):492-503
references.pmid: 17567960
references.citation: J Physiol Sci. 2012 Nov;62(6):453-60
references.pmid: 22851291
references.citation: J Physiol. 2004 Dec 1;561(Pt 2):379-86
references.pmid: 15486019
references.citation: Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2129-34
references.pmid: 15684075
references.citation: Endocrinology. 2009 Jan;150(1):376-84
references.pmid: 18703622
references.citation: Neuroscience. 1985 Dec;16(4):897-906
references.pmid: 3912679
references.citation: J Neurosci. 2012 Feb 15;32(7):2388-97
references.pmid: 22396413
references.citation: J Neuroendocrinol. 2012 Aug;24(8):1154-65
references.pmid: 22458373
references.citation: Endocrinology. 2007 Mar;148(3):1150-7
references.pmid: 17185374
references.citation: Neuropharmacology. 2010 Jan;58(1):314-20
references.pmid: 19559035
references.citation: J Neuroendocrinol. 2012 Oct;24(10):1284-95
references.pmid: 22530935
references.citation: Endocrinology. 2011 Apr;152(4):1541-50
references.pmid: 21325051
references.citation: Endocrinology. 1990 Feb;126(2):884-90
references.pmid: 2404750
references.citation: Histochemistry. 1988;89(2):129-39
references.pmid: 3294216
references.citation: J Neuroendocrinol. 2010 Sep;22(9):1032-9
references.pmid: 20584108
references.citation: J Neurosci. 2007 Oct 31;27(44):12088-95
references.pmid: 17978050
references.citation: Eur J Neurosci. 2010 Jun;31(11):1984-98
references.pmid: 20529119
references.citation: PLoS One. 2010 Jul 30;5(7):e11911
references.pmid: 20689830
references.citation: Peptides. 2009 Jan;30(1):103-10
references.pmid: 18619506
references.citation: Endocrinology. 2007 Apr;148(4):1774-83
references.pmid: 17204549
references.citation: Nat Genet. 2009 Mar;41(3):354-358
references.pmid: 19079066
references.citation: J Clin Endocrinol Metab. 2011 Mar;96(3):E536-45
references.pmid: 21193544
references.citation: J Mol Neurosci. 2011 Feb;43(2):138-45
references.pmid: 20665248
references.citation: Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1252-63
references.pmid: 23011064
references.citation: Endocrinology. 2010 Aug;151(8):3783-94
references.pmid: 20519367
references.citation: Endocrinology. 2009 May;150(5):2359-67
references.pmid: 19106226
references.citation: Toxicol Appl Pharmacol. 2011 Apr 1;252(1):36-46
references.pmid: 21277884
references.citation: Endocrinology. 2012 Jul;153(7):3331-6
references.pmid: 22585828
references.citation: Reprod Toxicol. 2011 Apr;31(3):280-9
references.pmid: 20951797
references.citation: Mol Cell Endocrinol. 2011 Aug 6;342(1-2):8-19
references.pmid: 21672609
references.citation: Endocrinology. 2012 Apr;153(4):1875-86
references.pmid: 22374971
references.citation: Neuroendocrinology. 2011;94(3):237-45
references.pmid: 21832818
references.citation: Neurosci Lett. 2006 Jul 3;401(3):225-30
references.pmid: 16621281
references.citation: Endocrinology. 2008 Aug;149(8):4151-7
references.pmid: 18450954
references.citation: Mol Cell Endocrinol. 2011 Oct 22;346(1-2):29-36
references.pmid: 21704672
references.citation: J Clin Endocrinol Metab. 2007 Jul;92(7):2744-50
references.pmid: 17488799
references.citation: J Reprod Dev. 2007 Apr;53(2):367-78
references.pmid: 17213691
references.citation: Endocrinology. 2010 May;151(5):2223-32
references.pmid: 20211970
references.citation: J Endocrinol. 2010 Nov;207(2):195-202
references.pmid: 20807723
references.citation: Mol Endocrinol. 2011 Dec;25(12):2157-68
references.pmid: 22016562
references.citation: Horm Behav. 2010 Apr;57(4-5):390-5
references.pmid: 19945459
references.citation: Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10714-9
references.pmid: 17563351
references.citation: Front Endocrinol (Lausanne). 2012 Apr 02;3:48
references.pmid: 22649420
references.citation: Endocrinology. 2007 Oct;148(10):4927-36
references.pmid: 17595229
references.citation: Endocrinology. 2010 Jan;151(1):301-11
references.pmid: 19880810
references.citation: FEBS Lett. 1999 Mar 5;446(1):103-7
references.pmid: 10100623
references.citation: Neuroendocrinology. 2012;96(1):1-12
references.pmid: 22354218
references.citation: Endocrinology. 2005 Sep;146(9):3686-92
references.pmid: 15919741
references.citation: J Mol Neurosci. 2011 Feb;43(2):146-54
references.pmid: 20680515
references.citation: N Engl J Med. 2008 Feb 14;358(7):709-15
references.pmid: 18272894
references.citation: Endocrinology. 2012 Aug;153(8):3770-9
references.pmid: 22691552
references.citation: Environ Health Perspect. 2009 Oct;117(10):1556-62
references.pmid: 20019906
references.citation: Nat Neurosci. 2011 Jun;14(6):704-10
references.pmid: 21516099
references.citation: Endocrinology. 2012 Sep;153(9):4522-32
references.pmid: 22778229
references.citation: Biol Reprod. 2012 Aug 02;87(2):28
references.pmid: 22572997
references.citation: Neuroscience. 2011 Jan 26;173:37-56
references.pmid: 21093546
references.citation: J Neuroendocrinol. 2009 Aug;21(8):683-9
references.pmid: 19500221
references.citation: Endocrinology. 2009 Jul;150(7):3214-20
references.pmid: 19299459
references.citation: Endocrinology. 2005 Sep;146(9):3917-25
references.pmid: 15932928
references.citation: Endocrinology. 2012 Feb;153(2):825-36
references.pmid: 22166978
references.citation: Endocrinology. 2004 Oct;145(10):4565-74
references.pmid: 15242985
references.citation: J Neurosci. 2009 Mar 25;29(12):3920-9
references.pmid: 19321788
references.citation: Reproduction. 2011 Apr;141(4):541-8
references.pmid: 21273366
references.citation: Front Neuroendocrinol. 2011 Aug;32(3):367-75
references.pmid: 21216259
references.citation: Endocrinology. 2011 Sep;152(9):3396-408
references.pmid: 21712362
references.citation: Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1212-21
references.pmid: 19755669
references.citation: J Neuroendocrinol. 2011 Sep;23(9):815-22
references.pmid: 21679258
references.citation: Reprod Toxicol. 2011 May;31(4):409-17
references.pmid: 21182934
references.citation: Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17217-22
references.pmid: 19805188
references.citation: Biol Sex Differ. 2012 Jan 19;3:2
references.pmid: 22260364
references.citation: N Engl J Med. 2012 Feb 16;366(7):629-35
references.pmid: 22335740
references.citation: Nature. 2001 May 31;411(6837):613-7
references.pmid: 11385580
references.citation: Endocrinology. 2009 Mar;150(3):1400-12
references.pmid: 18948403
references.citation: Endocrinology. 2012 Jan;153(1):316-28
references.pmid: 22067321
references.citation: Endocrinology. 2004 Oct;145(10):4653-9
references.pmid: 15231708
references.citation: Endocrinology. 2010 Jan;151(1):291-300
references.pmid: 19880809
references.citation: Endocrinology. 2012 Feb;153(2):782-93
references.pmid: 22202164
references.citation: Neurotoxicology. 2008 Nov;29(6):988-97
references.pmid: 18656497
references.citation: J Neuroendocrinol. 2012 Sep;24(9):1222-33
references.pmid: 22577852
references.citation: Cell Mol Life Sci. 2013 Mar;70(5):841-62
references.pmid: 22851226
references.citation: J Physiol. 2010 Mar 1;588(Pt 5):821-9
references.pmid: 20083512
references.citation: J Neuroendocrinol. 2009 Jan;21(1):20-9
references.pmid: 19094090
references.citation: Biol Reprod. 2012 Apr 19;86(4):119
references.pmid: 22278983
references.citation: J Neuroendocrinol. 2010 Oct;22(10):1101-12
references.pmid: 20673302
references.citation: Endocr Rev. 2009 Oct;30(6):713-43
references.pmid: 19770291
references.citation: Endocrinology. 1975 Oct;97(4):898-907
references.pmid: 1193012
references.citation: Endocrinology. 2009 Jul;150(7):3221-7
references.pmid: 19213830
references.citation: J Neurosci. 2006 Jun 21;26(25):6687-94
references.pmid: 16793876
references.citation: Endocrinology. 2008 May;149(5):2333-40
references.pmid: 18202134
references.citation: Curr Biol. 2006 Sep 5;16(17):1730-5
references.pmid: 16950111
references.citation: J Neuroendocrinol. 2011 Oct;23(10):871-82
references.pmid: 21793946
references.citation: Endocrinology. 2012 Jun;153(6):2756-65
references.pmid: 22434087
references.citation: Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10972-6
references.pmid: 12944565
references.citation: Neurotoxicology. 2012 Jan;33(1):23-36
references.pmid: 22101008
references.citation: Endocrinology. 2010 May;151(5):2233-43
references.pmid: 20207832
references.citation: Endocrinology. 2011 Feb;152(2):581-94
references.pmid: 21190954
references.citation: Neuroendocrinology. 2007;86(2):77-83
references.pmid: 17700012
references.citation: Endocrinology. 2012 Dec;153(12):5918-27
references.pmid: 23038740
references.citation: Endocrinology. 2010 Dec;151(12):5807-17
references.pmid: 20926580
references.citation: PLoS One. 2012;7(9):e44344
references.pmid: 23028524
references.citation: J Neuroendocrinol. 2010 Oct;22(10):1113-25
references.pmid: 20722977
references.citation: J Natl Cancer Inst. 1996 Dec 4;88(23):1731-7
references.pmid: 8944003
references.citation: Endocrinology. 2009 Nov;150(11):5016-26
references.pmid: 19734277
references.citation: J Reprod Fertil. 1980 May;59(1):217-22
references.pmid: 6772778
references.citation: Mol Cell Endocrinol. 2006 Sep 26;257-258:75-83
references.pmid: 16930819
references.citation: J Clin Endocrinol Metab. 2010 May;95(5):2276-80
references.pmid: 20237166
references.citation: J Clin Endocrinol Metab. 2012 Dec;97(12):E2221-9
references.pmid: 23015653
references.citation: Endocrinology. 2010 Jan;151(1):312-21
references.pmid: 19966188
references.citation: Eur J Endocrinol. 2007 Jul;157(1):113-8
references.pmid: 17609410