title: [Molecular mechanisms of chronic pain and its therapeutic strategy].
abstract: The contribution of numerous molecules for developing and maintaining the chronic pain state in patients has been gradually shown after the decade of pain control and research. However, many patients still have chronic pain which is difficult to treat even after the appearance of new analgesics. Therefore, a number of studies are still ongoing to find promising novel analgesics. We review several molecules being examined in ongoing studies including ionotropic and G-protein coupled receptors, which are mainly distributed in primary sensory afferents and/or spinal cord dorsal horn neurons.
authors.affiliation: Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi 371-8511.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Takazawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D002908:Chronic Disease; D050487:Glycine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D064729:Neurokinin-1 Receptor Antagonists; D010146:Pain / Q000188:drug therapy*; D018079:Receptors, GABA / Q000187:drug effects; D017470:Receptors, Glutamate / Q000187:drug effects; D018009:Receptors, Glycine / Q000037:antagonists & inhibitors; D011957:Receptors, Opioid / Q000187:drug effects; D018048:Receptors, Purinergic P2 / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D015222:Sodium Channels / Q000187:drug effects; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors
chemical_list: D000700:Analgesics; D050487:Glycine Plasma Membrane Transport Proteins; D064729:Neurokinin-1 Receptor Antagonists; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D018009:Receptors, Glycine; D011957:Receptors, Opioid; D018048:Receptors, Purinergic P2; D011985:Receptors, Serotonin; D015222:Sodium Channels; D050916:TRPV Cation Channels; C494484:TRPV1 receptor