title: Ethyl acetate as an acyl donor in the continuous flow kinetic resolution of (±)-1-phenylethylamine catalyzed by lipases.
abstract: The synthesis of chiral amines is still a challenge for organic synthesis since optically pure amines are of great importance for the pharmaceutical and agrochemical industries. Among all the methodologies developed until now, chemoenzymatic dynamic kinetic resolution has proven to be useful for the preparation of enantioenriched primary chiral amines. In our continuous efforts toward the development of a continuous flow process, herein we report our results on the continuous flow kinetic resolution of (±)-1-phenylethylamine leading to the desired products with high enantiomeric ratios (>200) and short residence times (40 minutes) using ethyl acetate as the acyl donor.
authors.affiliation: Biocatalysis and Organic Synthesis Group, Federal University of Rio de Janeiro, Chemistry Institute, Rio de Janeiro, Brazil.
authors.forename: Amanda S
authors.initials: AS
authors.lastname: de Miranda
authors.forename: Leandro S M
authors.initials: LS
authors.lastname: Miranda
authors.forename: Rodrigo O M A
authors.initials: RO
authors.lastname: de Souza
mesh_terms: D000085:Acetates / Q000737:chemistry / Q000378:metabolism*; D055162:Biocatalysis; D007700:Kinetics; D008049:Lipase / Q000378:metabolism*; D015394:Molecular Structure; D010627:Phenethylamines / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000085:Acetates; D010627:Phenethylamines; C007650:ethyl acetate; D008049:Lipase; C033198:1-phenethylamine