title: The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats.
abstract: Although increasing evidence demonstrates that both chronic stressors and inflammatory immune activation contribute to pathophysiology and behavioral alterations associated with major depression, little is known about the interaction effect of central inflammatory immune activation and stress on depressive-like behavior. Our previous work has shown that 14-day chronic forced swim stress induces significant depressive-like behavior. The present investigation assessed whether pro-inflammatory cytokine and anti-inflammatory cytokine challenges have differential interaction effect on depressive-like behavior induced by chronic forced swim stress in rats. The pro-inflammatory and anti-inflammatory immune challenges were achieved respectively by central administration of lipopolysaccharide (LPS), a pro-inflammatory cytokine inducer, and interleukin-10 (IL-10), an anti-inflammatory cytokine. It was found that either central LPS treatment alone or chronic forced swim stress alone significantly induced depressive-like behavior, including reduced body weight gain, reduced saccharin preference and reduced locomotor activity. However, there was no significant synergistic or additive effect of central LPS treatment and stress on depressive-like behavior. LPS treatment did not exacerbate the depressive-like behavior induced by forced swim stress. Nevertheless, IL-10 reversed depressive-like behavior induced by forced swim stress, a finding indicating that IL-10 has antidepressant effect on behavioral depression induced by stress. The present findings provide new insight into the complexity of the immunity-inflammation hypothesis of depression.
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Pan
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Lin
authors.forename: Weiwen
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Qi
authors.forename: Donglin
authors.initials: D
authors.lastname: Wang
authors.forename: Mingming
authors.initials: M
authors.lastname: Tang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D016207:Cytokines / Q000276:immunology; D003863:Depression / Q000276:immunology / Q000503:physiopathology*; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology*; D016753:Interleukin-10 / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000276:immunology / Q000502:physiology*; D013315:Stress, Psychological / Q000276:immunology / Q000503:physiopathology*; D013550:Swimming
chemical_list: D016207:Cytokines; D008070:Lipopolysaccharides; D016753:Interleukin-10