title: [Visfatin level after laparoscopic Roux-en-Y gastric bypass surgery in patients with Type 2 diabetes].
abstract: OBJECTIVE
  To investigate the change in serum visfatin level after laparoscopic Roux-en-Y gastric bypass surgery in patients with Type 2 diabetes mellitus (T2DM) and to explore the relationship between visfatin insulin resistance and diabetes.
  
  
  METHODS
  Thirty-three patients with Type 2 diabetes were studied before and after the gastric bypass surgery. The level of fasting serum visfatin was measured by enzyme-linked immunosorbent assay. Fasting plasma glucose (FPG), glycated hemoglobin (HbA1c) and fasting insulin (FINS) were measured before and after the gastric bypass surgery.
  
  
  RESULTS
  Compared with before the operation, the indicators of HbA1c, FINS, and insulin resistance index (HOMA-IR) were decreased after the laparoscopic Roux-en-Y gastric bypass surgery. The body mass index (BMI) [(24.53 ± 0.62) kg/m² vs (26.71 ± 0.69) kg/m2] was decreased, with significant difference (P<0.001). The serum visfatin level [(9.79 ± 0.64) ng/mL] was significantly lower than before the operation [(38.24 ± 5.32) ng/mL], with significant difference (P<0.001).
  
  
  CONCLUSIONS
  Serum level of visfatin is decreased in T2DM patients who undergo gastric bypass surgry, reflecting an improvement in insulin resistance and diabetes.
authors.affiliation: Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China. easd04mzh@126.com
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Xiong
authors.forename: Honghui
authors.initials: H
authors.lastname: He
authors.forename: Shaihong
authors.initials: S
authors.lastname: Zhu
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Mo
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000601:surgery*; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D007333:Insulin Resistance; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011184:Postoperative Period
chemical_list: D054409:Nicotinamide Phosphoribosyltransferase