title: Ribonucleoproteins in archaeal pre-rRNA processing and modification.
abstract: Given that ribosomes are one of the most important cellular macromolecular machines, it is not surprising that there is intensive research in ribosome biogenesis. Ribosome biogenesis is a complex process. The maturation of ribosomal RNAs (rRNAs) requires not only the precise cleaving and folding of the pre-rRNA but also extensive nucleotide modifications. At the heart of the processing and modifications of pre-rRNAs in Archaea and Eukarya are ribonucleoprotein (RNP) machines. They are called small RNPs (sRNPs), in Archaea, and small nucleolar RNPs (snoRNPs), in Eukarya. Studies on ribosome biogenesis originally focused on eukaryotic systems. However, recent studies on archaeal sRNPs have provided important insights into the functions of these RNPs. This paper will introduce archaeal rRNA gene organization and pre-rRNA processing, with a particular focus on the discovery of the archaeal sRNP components, their functions in nucleotide modification, and their structures.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: W S Vincent
authors.initials: WS
authors.lastname: Yip
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Vincent
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Baserga
mesh_terms: D001105:Archaea / Q000235:genetics* / Q000378:metabolism*; D019848:Gene Expression Regulation, Archaeal; D012322:RNA Precursors / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012261:Ribonucleoproteins / Q000378:metabolism*
chemical_list: D012322:RNA Precursors; D012261:Ribonucleoproteins
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