title: Molecular virology of hepatitis E virus.
abstract: Hepatitis E virus (HEV) is the causative agent of hepatitis E. It is a nonenveloped virus with a ∼7.2 kilobases positive-stranded RNA genome. The molecular virology of HEV is getting better understood with the development of replicons and in vitro infection systems, and the discovery of related viruses that infect animal species other than humans. This review focuses on the virology of HEV and updates the current knowledge on the HEV genome and its constituent proteins--ORF1, ORF2, and ORF3, and the viral life cycle.
authors.affiliation: Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
authors.forename: R Prasida
authors.initials: RP
authors.lastname: Holla
authors.forename: Imran
authors.initials: I
authors.lastname: Ahmad
authors.forename: Zulfazal
authors.initials: Z
authors.lastname: Ahmad
authors.forename: Shahid
authors.initials: S
authors.lastname: Jameel
mesh_terms: D016679:Genome, Viral; D016751:Hepatitis E / Q000453:epidemiology / Q000628:therapy / Q000821:virology*; D016752:Hepatitis E virus / Q000235:genetics*; D006801:Humans; D014764:Viral Proteins / Q000502:physiology*
chemical_list: D014764:Viral Proteins