title: Efficacy and safety of novel anticoagulants compared with established agents.
abstract: Dabigatran, rivaroxaban, and apixaban are novel oral anticoagulants that offer major advantages over existing agents. The onset of the anticoagulant effect of these agents is rapid. Each agent has a predictable anticoagulant response that eliminates the need for monitoring. Clinical trials have been completed with all three agents in the prevention and treatment of the three leading causes of cardiovascular death: myocardial infarction, stroke, and venous thromboembolism (VTE). Novel agents have shown reduced or similar rates of thrombosis, major bleeding, and adverse events when weighed against either low molecular weight heparin or warfarin. Additional trials are underway and more agents are in development. As a result, novel anticoagulants may impact physician prescribing practices and warrant consideration in patients requiring thrombosis management.
authors.affiliation: Department of Pharmacy, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Iwona
authors.initials: I
authors.lastname: Rybak
authors.forename: Michael
authors.initials: M
authors.lastname: Ehle
authors.forename: Leo
authors.initials: L
authors.lastname: Buckley
authors.forename: John
authors.initials: J
authors.lastname: Fanikos
keywords: acute coronary syndromes; anticoagulation; apixaban; atrial fibrillation; dabigatran; prophylaxis; rivaroxaban; venous thromboembolism; warfarin
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