title: Zotepine-induced convulsive seizures in a chronic case of treatment resistant paranoid schizophrenia.
abstract: Adverse effects to antipsychotics are varied, frequently intolerable, often serious and sometimes fatal in clinical practice. Seizures are one of these adverse effects. Almost all first and second generation antipsychotics elicit dose-dependent lowering of seizure threshold, indicating increased seizure risk at higher drug dosages. The adverse event of zotepine induced seizure is published in few case reports. We report the occurrence of myoclonic seizure progressing to generalized tonic-clonic seizures with zotepine along with clear temporal association of dose dependent modulation evident in this case.
authors.affiliation: Department of Psychiatry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Khairkar
authors.forename: Neha
authors.initials: N
authors.lastname: Gupta
authors.forename: Sushil Kumar
authors.initials: SK
authors.lastname: Varma
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D003988:Dibenzothiepins / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006212:Hallucinations / Q000139:chemically induced*; D006801:Humans; D008297:Male; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D012640:Seizures / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D003988:Dibenzothiepins; C022172:zotepine
keywords: Adverse effect; convulsive seizure; treatment resistant schizophrenia; zotepine
references.citation: Drug Saf. 2002;25(2):91-110
references.pmid: 11888352
references.citation: Clin Pharmacol Ther. 1981 Aug;30(2):239-45
references.pmid: 7249508
references.citation: Psychopharmacology (Berl). 2000 Jun;150(3):237-43
references.pmid: 10923750
references.citation: Schizophr Res. 2006 Oct;87(1-3):332-3
references.pmid: 16797164
references.citation: Expert Opin Drug Saf. 2003 May;2(3):233-47
references.pmid: 12904103
references.citation: Neurology. 1999;53(5 Suppl 2):S68-75
references.pmid: 10496236
references.citation: Neurology. 1991 Mar;41(3):369-71
references.pmid: 2006003
references.citation: Ther Drug Monit. 1994 Apr;16(2):120-4
references.pmid: 7912012
references.citation: Epilepsia. 2004 Dec;45(12):1613-22
references.pmid: 15571520
references.citation: Jpn J Psychiatry Neurol. 1992 Mar;46(1):161-7
references.pmid: 1353125