title: Translating the concept of peptide labeling with 5-deoxy-5-[18F]fluororibose into preclinical practice: 18F-labeling of Siglec-9 peptide for PET imaging of inflammation.
abstract: Peptide glycosylation with 5-deoxy-5-[(18)F]fluororibose was translated into preclinical settings. The novel (18)F-labeled Siglec-9 peptide was produced using an automated synthesis procedure. The (18)F-labeled Siglec-9 peptide showed favorable binding in the animal model of inflammation in vivo.
authors.affiliation: Department of Pharmacology, Drug Development and Therapeutics, University of Turku, FI-20014 Turku, Finland. xiali@utu.fi and Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland. anne.roivainen@utu.fi.
authors.forename: Xiang-Guo
authors.initials: XG
authors.lastname: Li
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland. anne.roivainen@utu.fi.
authors.forename: Anu
authors.initials: A
authors.lastname: Autio
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland. anne.roivainen@utu.fi.
authors.forename: Helena
authors.initials: H
authors.lastname: Ahtinen
authors.affiliation: Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland. anu.airaksinen@helsinki.fi.
authors.forename: Kerttuli
authors.initials: K
authors.lastname: Helariutta
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland. anne.roivainen@utu.fi and Turku Center for Disease Modeling, University of Turku, FI-20014 Turku, Finland.
authors.forename: Heidi
authors.initials: H
authors.lastname: Liljenbäck
authors.affiliation: MediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, FI-20014 Turku, Finland.
authors.forename: Sirpa
authors.initials: S
authors.lastname: Jalkanen
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland. anne.roivainen@utu.fi and Turku Center for Disease Modeling, University of Turku, FI-20014 Turku, Finland.
authors.forename: Anne
authors.initials: A
authors.lastname: Roivainen
authors.affiliation: Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland. anu.airaksinen@helsinki.fi.
authors.forename: Anu J
authors.initials: AJ
authors.lastname: Airaksinen
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D000818:Animals; D015703:Antigens, CD / Q000737:chemistry*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D007249:Inflammation / Q000175:diagnosis / Q000378:metabolism; D010455:Peptides / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods; D051381:Rats; D012266:Ribose / Q000031:analogs & derivatives / Q000737:chemistry; D063265:Sialic Acid Binding Immunoglobulin-like Lectins / Q000737:chemistry*
chemical_list: C547238:5-deoxy-5-(18F)fluororibose; D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D010455:Peptides; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D012266:Ribose; D006631:Amine Oxidase (Copper-Containing); C510433:vascular adhesion protein-1, rat