title: A comparison of brain activity between healthy subjects and stroke patients on fMRI by acupuncture stimulation.
abstract: OBJECTIVE
  To investigate brain activity patterns during acupuncture in stroke patients, and to compare the result with normal subjects using functional magnetic resonance imaging (fMRI).
  
  
  METHODS
  A total of 11 stroke patients with motor weakness and 10 healthy subjects were studied. fMRI was performed during acupuncture on the left side at points Quchi (LI11) and Zusanli (ST36). Data were analyzed using statistical parametric maps of brain activation induced by acupuncture stimulation.
  
  
  RESULTS
  The results showed that stimulation of both LI11 and ST36 produced significantly different brain activation patterns between the two groups. The normal group showed a greater overall activation than the stroke group. In the normal group, parts of the frontal lobe, parietal lobe, sub-lobar, cerebellum and midbrain regions were activated by acupuncture at the left LI11. On the other hand, only the right side of the inferior parietal lobule region was activated in the stroke patients. When the left ST36 was stimulated in the normal group, both sides of the frontal lobe, parietal lobe, temporal lobe, and sub-lobar, and the left side of occipital lobe, and the right side of cerebellum and midbrain regions were activated. For the same stimulation in the stroke group, only both sides of the inferior parietal lobule and cerebellum regions were activated (P<0.05, cluster level). Deactivation pattern was not noted during any acupuncture stimulation in both groups.
  
  
  CONCLUSIONS
  Brain signal activations during the same acupuncture were different between the healthy and the stroke patients, and the effects showed a correlation of different acupuncture points.
authors.affiliation: Department of Cardiology and Neurology of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Seung-Yeon
authors.initials: SY
authors.lastname: Cho
authors.forename: Mia
authors.initials: M
authors.lastname: Kim
authors.forename: Jong Joo
authors.initials: JJ
authors.lastname: Sun
authors.forename: Geon-Ho
authors.initials: GH
authors.lastname: Jahng
authors.forename: Hengjun J
authors.initials: HJ
authors.lastname: Kim
authors.forename: Seong-Uk
authors.initials: SU
authors.lastname: Park
authors.forename: Woo-Sang
authors.initials: WS
authors.lastname: Jung
authors.forename: Chang-Nam
authors.initials: CN
authors.lastname: Ko
authors.forename: Jung-Mi
authors.initials: JM
authors.lastname: Park
mesh_terms: D015670:Acupuncture Therapy; D000368:Aged; D001931:Brain Mapping; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D006262:Health; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000503:physiopathology*
references.citation: Neuroimage. 2002 Aug;16(4):1028-37
references.pmid: 12202090
references.citation: J Altern Complement Med. 2008 Jul;14(6):673-8
references.pmid: 18684074
references.citation: Neuron. 2008 Nov 26;60(4):543-54
references.pmid: 19038213
references.citation: Am J Chin Med. 2005;33(4):573-8
references.pmid: 16173531
references.citation: Neurosci Lett. 2009 Jul 10;458(1):6-10
references.pmid: 19442868
references.citation: Hum Brain Mapp. 1997;5(4):238-42
references.pmid: 20408222
references.citation: Ann Neurol. 1993 Feb;33(2):181-9
references.pmid: 8434880
references.citation: PLoS One. 2010 Apr 15;5(4):e10198
references.pmid: 20419166
references.citation: Neuroimage. 2005 Jul 1;26(3):839-51
references.pmid: 15955494
references.citation: Top Stroke Rehabil. 2007 Jul-Aug;14(4):40-58
references.pmid: 17698457
references.citation: Neurosci Lett. 2010 Sep 27;482(2):95-100
references.pmid: 20619317
references.citation: Mov Disord. 2009 Sep 15;24(12):1794-802
references.pmid: 19533753
references.citation: J Neurophysiol. 1998 Apr;79(4):2119-48
references.pmid: 9535973
references.citation: Cereb Cortex. 2006 Feb;16(2):149-61
references.pmid: 15858164
references.citation: Brain Res. 2012 Feb 3;1436:34-42
references.pmid: 22197696
references.citation: Curr Opin Neurobiol. 1997 Apr;7(2):157-63
references.pmid: 9142758
references.citation: J Magn Reson Imaging. 2006 Nov;24(5):1018-24
references.pmid: 16969787
references.citation: J Altern Complement Med. 2007 Jun;13(5):527-32
references.pmid: 17604556
references.citation: BMC Complement Altern Med. 2008 Jul 07;8:37
references.pmid: 18606019
references.citation: Science. 2005 Nov 4;310(5749):805-10
references.pmid: 16272112
references.citation: Arch Phys Med Rehabil. 2003 Nov;84(11):1692-702
references.pmid: 14639572
references.citation: Curr Opin Neurobiol. 2001 Dec;11(6):663-72
references.pmid: 11741015
references.citation: Hum Brain Mapp. 2000 Jul;10(3):120-31
references.pmid: 10912591
references.citation: J Child Neurol. 2008 Nov;23(11):1267-74
references.pmid: 18984835
references.citation: Cortex. 2009 Oct;45(9):1091-6
references.pmid: 19232583
references.citation: J Altern Complement Med. 2010 Apr;16(4):489-95
references.pmid: 20423217
references.citation: Neurosci Lett. 2010 Aug 2;479(3):267-71
references.pmid: 20573575
references.citation: Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:2784-7
references.pmid: 22254919
references.citation: Neuroimage. 2002 Jan;15(1):190-9
references.pmid: 11771988
references.citation: Arch Phys Med Rehabil. 2005 Dec;86(12):2248-55
references.pmid: 16344019
references.citation: Stroke. 2010 Apr;41(4):e171-9
references.pmid: 20167912
references.citation: Hum Brain Mapp. 2009 Apr;30(4):1196-206
references.pmid: 18571795
references.citation: Neuroimage. 2004 Jun;22(2):656-64
references.pmid: 15193594
references.citation: J Altern Complement Med. 2009 Nov;15(11):1193-200
references.pmid: 19922250
references.citation: Nature. 2002 Dec 19-26;420(6917):788-94
references.pmid: 12490942
references.citation: J Magn Reson Imaging. 2011 Jul;34(1):31-42
references.pmid: 21698705
references.citation: Neuroimage. 2009 Sep;47(3):1066-76
references.pmid: 19501656
references.citation: Arch Phys Med Rehabil. 1993 Jun;74(6):602-11
references.pmid: 8503750