title: CASP8 promoter polymorphism, mRNA expression and risk of prostate cancer among Chinese men.
abstract: Caspase-8 (CASP8) plays a key role in apoptosis. We examined by genotyping whether the -652 six-nucleotide insertion-deletion (6N ins/del) polymorphism in the CASP8 promoter region was associated with prostate cancer risk in a hospital-based case-control study of 406 Chinese prostate cancer patients and 408 age-matched cancer-free controls. Additionally, 23 prostate cancer tissues were analyzed for CASP8 mRNA expression. We found a significantly decreased prostate cancer risk for the 6N ins/del genotype [adjusted odds ratio (OR)=0.68; 95% confidence interval (CI)=0.51-0.92] and del/del genotype (OR=0.34; 95% CI=0.19-0.63) compared with the ins/ins genotype. The 6N del allele was associated dose-dependently with decreased prostate cancer risk (P trend = 0.001). RT-PCR showed that individuals with the 6N del allele had lower CASP8 mRNA levels than those with the ins/ins genotype (P = 0.024). These findings suggested that the CASP8-652 6N ins/del polymorphism may affect the susceptibility to prostate cancer and reduce prostate cancer risk among Chinese men.
authors.affiliation: Key Laboratory of Reproductive Medicine, School of Public Health, Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 210029, China ; Department of Urology, Huai-An First Affiliated Hospital, Nanjing Medical University, Huai-An, Jiangsu 211000, China.
authors.forename: Guangbo
authors.initials: G
authors.lastname: Fu
authors.forename: Jialin
authors.initials: J
authors.lastname: Tang
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Qin
authors.forename: Fu
authors.initials: F
authors.lastname: Yan
authors.forename: Qi
authors.initials: Q
authors.lastname: Ding
authors.forename: Changjun
authors.initials: C
authors.lastname: Yin
authors.forename: Xinru
authors.initials: X
authors.lastname: Wang
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
keywords: caspase-8; genetic variation; promoter polymorphism; prostate cancer
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