title: Chromatin architecture defines the glucocorticoid response.
abstract: The glucocorticoid receptor (GR) functions to regulate a wide group of physiological processes through hormone inducible interaction with genomic loci and subsequent manipulation of the transcriptional output of target genes. Despite expression in a wide variety of tissues, the GR has diverse roles that are regulated tightly in a cell type specific manner. With the advent of whole genome approaches, the details of that diversity and the mechanisms regulating them are beginning to be elucidated. This review aims describe the recent advances detailing the role chromatin structure plays in dictating GR specificity.
authors.affiliation: Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, United States. Electronic address: craig.burd@osumc.edu.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Burd
authors.forename: Trevor K
authors.initials: TK
authors.lastname: Archer
mesh_terms: D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D015894:Genome, Human; D005938:Glucocorticoids / Q000502:physiology*; D006801:Humans; D009690:Nucleic Acid Conformation; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D011965:Receptors, Glucocorticoid / Q000502:physiology
chemical_list: D002843:Chromatin; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid
keywords: Chromatin; Glucocorticoid receptor; Nuclear receptor
references.citation: Endocr Rev. 2000 Feb;21(1):55-89
references.pmid: 10696570
references.citation: Nucleic Acids Res. 2009 Jul;37(12):4135-48
references.pmid: 19433513
references.citation: Trends Genet. 2012 Jun;28(6):276-84
references.pmid: 22487374
references.citation: Mol Cell Biol. 2009 Oct;29(20):5413-25
references.pmid: 19687299
references.citation: Curr Opin Genet Dev. 2011 Apr;21(2):175-86
references.pmid: 21342762
references.citation: PLoS One. 2010 Dec 20;5(12):e15188
references.pmid: 21187916
references.citation: Genome Res. 2009 Dec;19(12):2163-71
references.pmid: 19801529
references.citation: J Biol Chem. 2009 Mar 6;284(10):6048-52
references.pmid: 19124469
references.citation: J Cell Biochem. 2008 Aug 1;104(5):1580-6
references.pmid: 18393355
references.citation: Cell. 2009 Jul 23;138(2):245-56
references.pmid: 19632176
references.citation: Mol Cell Biol. 2011 Aug;31(16):3267-76
references.pmid: 21646426
references.citation: Nat Genet. 2011 Mar;43(3):264-8
references.pmid: 21258342
references.citation: Cancer Res. 2008 Nov 1;68(21):9041-9
references.pmid: 18974150
references.citation: Genome Res. 2011 Sep;21(9):1404-16
references.pmid: 21750107
references.citation: Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10275-9
references.pmid: 7937940
references.citation: Sci Aging Knowledge Environ. 2003 Apr 09;2003(14):RE4
references.pmid: 12844523
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931-6
references.pmid: 21106759
references.citation: Nat Genet. 2009 Aug;41(8):941-5
references.pmid: 19633671
references.citation: Mol Cell Biol. 1991 Feb;11(2):688-98
references.pmid: 1846670
references.citation: Nature. 2007 Jun 14;447(7146):799-816
references.pmid: 17571346
references.citation: Cell. 2008 Mar 21;132(6):958-70
references.pmid: 18358809
references.citation: EMBO J. 1987 Aug;6(8):2321-8
references.pmid: 2822386
references.citation: EMBO J. 2009 May 20;28(10):1418-28
references.pmid: 19339991
references.citation: Annu Rev Genet. 2009;43:559-99
references.pmid: 19886812
references.citation: Cancer Res. 2011 Oct 15;71(20):6360-70
references.pmid: 21868756
references.citation: Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11112-7
references.pmid: 16840560
references.citation: Mol Cell. 2011 Jul 8;43(1):145-55
references.pmid: 21726817
references.citation: Cell. 1995 Dec 15;83(6):835-9
references.pmid: 8521507
references.citation: EMBO J. 2011 Jun 24;30(15):3028-39
references.pmid: 21701563
references.citation: Ann N Y Acad Sci. 1993 Jun 11;684:196-8
references.pmid: 8391238
references.citation: Mol Endocrinol. 2012 Apr;26(4):538-49
references.pmid: 22322598
references.citation: Cell. 1990 Mar 9;60(5):719-31
references.pmid: 2155706
references.citation: Mol Cell Endocrinol. 2007 Feb;265-266:162-7
references.pmid: 17240047
references.citation: Gene. 2009 Feb 15;431(1-2):1-12
references.pmid: 19059319
references.citation: Mol Cell. 2002 Feb;9(2):279-89
references.pmid: 11864602
references.citation: Cell. 2011 Oct 28;147(3):565-76
references.pmid: 22036565
references.citation: Cell. 2011 Apr 15;145(2):224-41
references.pmid: 21496643
references.citation: PLoS Genet. 2007 Jun;3(6):e94
references.pmid: 17559307
references.citation: Nat Genet. 2006 Nov;38(11):1289-97
references.pmid: 17013392
references.citation: Genes Dev. 2008 Nov 1;22(21):2953-67
references.pmid: 18981474
references.citation: BMC Neurosci. 2012 Oct 03;13:118
references.pmid: 23031785
references.citation: Nucleic Acids Res. 1997 Sep 15;25(18):3733-42
references.pmid: 9278498
references.citation: EMBO J. 2011 Apr 20;30(8):1459-72
references.pmid: 21427703
references.citation: Mol Cell. 2008 Mar 14;29(5):611-24
references.pmid: 18342607
references.citation: Exp Cell Res. 2009 Sep 10;315(15):2604-15
references.pmid: 19463811
references.citation: J Biol Chem. 2007 Mar 16;282(11):8284-91
references.pmid: 17186943
references.citation: Nature. 1994 Aug 11;370(6489):477-81
references.pmid: 8047169
references.citation: Cancer Lett. 2012 Feb 1;315(1):38-47
references.pmid: 22055461
references.citation: Genome Res. 2011 May;21(5):697-706
references.pmid: 21471403
references.citation: Nat Genet. 2010 Apr;42(4):343-7
references.pmid: 20208536
references.citation: Cell. 2011 Aug 19;146(4):544-54
references.pmid: 21835447
references.citation: Nature. 2011 Feb 10;470(7333):279-83
references.pmid: 21160473
references.citation: Cell. 2007 May 18;129(4):823-37
references.pmid: 17512414
references.citation: Nat Rev Endocrinol. 2012 Oct;8(10):598-604
references.pmid: 22733267
references.citation: FEBS Lett. 2001 Apr 13;494(3):135-40
references.pmid: 11311228
references.citation: Mol Cell Biol. 2002 May;22(10):3255-63
references.pmid: 11971959
references.citation: Mol Cell Biol. 2012 May;32(10):1805-17
references.pmid: 22451486
references.citation: Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14173-8
references.pmid: 9826673
references.citation: Cell. 2005 Jul 15;122(1):33-43
references.pmid: 16009131
references.citation: Science. 1992 Mar 20;255(5051):1573-6
references.pmid: 1347958
references.citation: Cell. 2003 Mar 7;112(5):725-36
references.pmid: 12628191
references.citation: Nat Genet. 2007 Mar;39(3):311-8
references.pmid: 17277777
references.citation: Cell Mol Life Sci. 1998 Feb;54(2):113-24
references.pmid: 9539951
references.citation: Mol Cell Biol. 2012 Sep;32(18):3756-67
references.pmid: 22801371
references.citation: Cell. 1991 Feb 8;64(3):565-72
references.pmid: 1846780
references.citation: Nat Struct Mol Biol. 2013 Jan;20(1):53-8
references.pmid: 23222642
references.citation: Nature. 1997 Sep 18;389(6648):251-60
references.pmid: 9305837
references.citation: Exp Cell Res. 2005 Apr 1;304(2):593-603
references.pmid: 15748903
references.citation: Genes Dev. 2006 Sep 15;20(18):2513-26
references.pmid: 16980581
references.citation: PLoS One. 2011;6(8):e23490
references.pmid: 21853138
references.citation: Nucl Recept Signal. 2008 Feb 01;6:e004
references.pmid: 18301784
references.citation: Exp Cell Res. 2012 Jan 1;318(1):61-74
references.pmid: 22001115
references.citation: Nature. 1998 May 7;393(6680):88-91
references.pmid: 9590696
references.citation: Cell. 1987 Nov 6;51(3):435-43
references.pmid: 2889531