title: Fatal anaphylactic reaction to iron sucrose in pregnancy.
abstract: Iron-deficiency anemia in pregnancy can have serious deleterious effects for both mother and fetus. Parenteral iron therapy in iron-deficiency anemia is recommended in patients where oral iron therapy is ineffective due to malabsorption states and non-compliance. Compared to oral iron therapy, intravenous iron results in much more rapid resolution of iron-deficiency anemia with minimal adverse reactions. Iron sucrose has a favorable safety profile and is an alternative to other forms of parenteral iron therapy in correction of iron stores depletion. Immune mechanisms and iron agent releasing bioactive, partially unbound iron into the circulation, resulting in oxidative stress appears to cause severe adverse reactions. Although iron sucrose has a favorable safety profile in comparison to other parenteral iron preparations, this report highlights a fatal anaphylactic shock to iron sucrose in a pregnant woman with severe iron deficiency non-compliant to oral iron therapy.
authors.affiliation: Department of Medicine, Pramukhswami Medical College, Karamsad, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Mishra
authors.forename: Nikhil
authors.initials: N
authors.lastname: Dave
authors.forename: Kishor
authors.initials: K
authors.lastname: Viradiya
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D005290:Ferric Compounds / Q000009:adverse effects*; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid / Q000009:adverse effects*; D006397:Hematinics / Q000009:adverse effects*; D006801:Humans; D011247:Pregnancy; D055815:Young Adult
chemical_list: D005290:Ferric Compounds; D006397:Hematinics; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid
keywords: Anaphylactic Reaction; fatal; iron sucrose; pregnancy
references.citation: Eur J Obstet Gynecol Reprod Biol. 2003 Sep 10;110(1):2-7
references.pmid: 12932861
references.citation: Br J Nutr. 2002 Jul;88(1):3-10
references.pmid: 12117422
references.citation: Am J Obstet Gynecol. 2002 Mar;186(3):518-22
references.pmid: 11904617
references.citation: Am J Nephrol. 1997;17(5):477-9
references.pmid: 9382172
references.citation: Am J Kidney Dis. 2006 May;47(5 Suppl 3):S11-145
references.pmid: 16678659
references.citation: Am J Kidney Dis. 2001 Nov;38(5):988-91
references.pmid: 11684551
references.citation: Nephrol Dial Transplant. 2005 Jul;20(7):1443-9
references.pmid: 15855210