title: pH-controlled delivery of nanoparticles into tumor cells.
abstract: Nanoparticles target tumor cells by pH-controlled means. Nanoparticles carry three synergistic delivery functions: 1) tumor tissue targeting by the EPR effect; 2) tumor cell targeting by pHLIP-mediated membrane-localization; and 3) tumor cell uptake by adsorptive-mediated endocytosis.
authors.affiliation: Key Laboratory of Smart Drug Delivery, Ministry of Education& PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Han
authors.forename: Haojun
authors.initials: H
authors.lastname: Ma
authors.forename: Yubo
authors.initials: Y
authors.lastname: Guo
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Kuang
authors.forename: Xi
authors.initials: X
authors.lastname: He
authors.forename: Chen
authors.initials: C
authors.lastname: Jiang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D050091:Dendrimers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D010455:Peptides / Q000737:chemistry; D010957:Plasmids / Q000378:metabolism; D011092:Polyethylene Glycols; D011107:Polylysine / Q000737:chemistry
chemical_list: D050091:Dendrimers; D010455:Peptides; D011107:Polylysine; D011092:Polyethylene Glycols; D004247:DNA
keywords: gene delivery; nanoparticles; targeting acidity; tumor-targeting delivery