title: Ostreol A: a new cytotoxic compound isolated from the epiphytic dinoflagellate Ostreopsis cf. ovata from the coastal waters of Jeju Island, Korea.
abstract: Ostreol A was isolated from cultures of the epiphytic dinoflagellate Ostreopsis cf. ovata from the coastal waters of Jeju Island, Korea. The compound, a non-palytoxin derivative, has a polyhydroxy chain ending with the primary amino group and contains an amide bond, along with two tetrahydropyran rings in the chain. Its chemical structure was elucidated by nuclear magnetic resonance (NMR) spectroscopy methods and confirmed by mass analysis. The compound exhibited significant cytotoxicity in the brine shrimp lethality test at a concentration of 0.9μg/mL.
authors.affiliation: Department of Oceanography, Kunsan National University, Jeonbuk 573-701, Republic of Korea.
authors.forename: Buyng Su
authors.initials: BS
authors.lastname: Hwang
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Yoon
authors.forename: Hyung Seop
authors.initials: HS
authors.lastname: Kim
authors.forename: Wonho
authors.initials: W
authors.lastname: Yih
authors.forename: Jae Yeon
authors.initials: JY
authors.lastname: Park
authors.forename: Hae Jin
authors.initials: HJ
authors.lastname: Jeong
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
mesh_terms: D000818:Animals; D001156:Artemia / Q000166:cytology / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004141:Dinoflagellida / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D054813:Polyhydroxyalkanoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D056910:Republic of Korea; D012623:Seawater / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D054813:Polyhydroxyalkanoates; D011714:Pyrans; C584283:ostreol A