title: Localization of myocardial scar in patients with cardiomyopathy and left bundle branch block using electrocardiographic Selvester QRS scoring.
abstract: BACKGROUND
  Outcome of cardiac resynchronization therapy is severely worsened by myocardial scar at the left ventricular (LV) pacing site. We aimed to describe the diagnostic performance of electrocardiographic (ECG) criteria based on the Selvester QRS scoring system, first in localizing myocardial scar and second in screening for any non-septal scar in patients with strictly defined LBBB.
  
  
  RESULTS
  In 39 cardiomyopathy patients with LBBB, 17 with scar, 22 without scar, late gadolinium-enhancement cardiac magnetic resonance images (CMR-LGE) and 12-lead ECGs were analyzed for scar presence in 5 LV wall segments. The ECG criteria with the best diagnostic performance in detecting scar in each segment and in the four non-septal segments together were identified. Criteria for detecting non-septal scar had 75% (95% CI: 51%-90%) sensitivity, 95% (78%-99%) specificity, 92% (67%-99%) positive predictive value and 84% (65%-94%) negative predictive value. For each individual wall segment, 40%-60% sensitivities and 77%-100% specificities were found.
  
  
  CONCLUSIONS
  The 12-lead ECG can convey information about scar presence and location in this population of cardiomyopathy patients with LBBB. ECG screening criteria for scar in potential CRT LV pacing sites were identified. Further exploration is required to determine the clinical utility of the 12-lead ECG in combination with other imaging modalities to screen for scar in potential LV pacing sites in CRT candidates.
authors.affiliation: Cardiac MR Group, Department of Clinical Physiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Wieslander
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Wu
authors.forename: Zak
authors.initials: Z
authors.lastname: Loring
authors.forename: Linus G
authors.initials: LG
authors.lastname: Andersson
authors.forename: Terry F
authors.initials: TF
authors.lastname: Frank
authors.forename: Gary
authors.initials: G
authors.lastname: Gerstenblith
authors.forename: Gordon F
authors.initials: GF
authors.lastname: Tomaselli
authors.forename: Robert G
authors.initials: RG
authors.lastname: Weiss
authors.forename: Galen S
authors.initials: GS
authors.lastname: Wagner
authors.forename: Martin
authors.initials: M
authors.lastname: Ugander
authors.forename: David G
authors.initials: DG
authors.lastname: Strauss
mesh_terms: D000465:Algorithms; D002037:Bundle-Branch Block / Q000150:complications* / Q000175:diagnosis*; D009202:Cardiomyopathies / Q000150:complications* / Q000175:diagnosis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017682:Myocardial Stunning / Q000175:diagnosis* / Q000209:etiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
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