title: Nuclear receptors as drug targets in cholestatic liver diseases.
abstract: Cholestatic liver diseases encompass a wide spectrum of disorders with different causes, resulting in impaired bile flow and accumulation of bile acids and other potentially hepatotoxic cholephils. The understanding of the molecular mechanisms of bile formation and cholestasis has recently improved significantly through new insights into nuclear receptor (patho)biology. Nuclear receptors are ligand-activated transcription factors, which act as central players in the regulation of genes responsible for elimination and detoxification of biliary constituents accumulating in cholestasis. They also control other pathophysiologic processes such as inflammation, fibrogenesis, and carcinogenesis involved in the pathogenesis and disease progression of cholestasis liver diseases.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Emina
authors.initials: E
authors.lastname: Halilbasic
authors.forename: Anna
authors.initials: A
authors.lastname: Baghdasaryan
authors.forename: Michael
authors.initials: M
authors.lastname: Trauner
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002779:Cholestasis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D000090702:Constitutive Androstane Receptor; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D000077297:Pregnane X Receptor; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000235:genetics / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D011987:Receptors, Steroid / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D000090702:Constitutive Androstane Receptor; D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors; D000077297:Pregnane X Receptor; D018167:Receptors, Calcitriol; D018160:Receptors, Cytoplasmic and Nuclear; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D014580:Ursodeoxycholic Acid; D000099150:Receptor, Farnesoid X-Activated
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