title: [Vascular calcifications and vitamin K deficiency: a modifiable risk factor in chronic kidney disease].
abstract: The mechanisms of vascular calcifications in chronic renal failure are complex. Apart for clotting factors, vitamin K-dependent proteins include matrix Gla protein. Glutamic acid residues in matrix Gla protein are carboxylated by vitamin K-dependent gamma-carboxylase, which enables it to inhibit calcification. The purpose of this review is to discuss available evidence implicating vitamin K as a modifiable risk factor in the pathogenesis of vascular calcification in renal diseases.
authors.affiliation: Service de néphrologie et d'hypertension, Département de médecine interne, CHUV, 1011 Lausanne. olivier.phan@chuv.ch
authors.forename: O
authors.initials: O
authors.lastname: Phan
authors.forename: M
authors.initials: M
authors.lastname: Burnier
mesh_terms: D015987:Effect Modifier, Epidemiologic; D006801:Humans; D008954:Models, Biological; D009747:Nutritional Physiological Phenomena; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000453:epidemiology*; D012307:Risk Factors; D061205:Vascular Calcification / Q000453:epidemiology / Q000209:etiology*; D014812:Vitamin K / Q000502:physiology; D014813:Vitamin K Deficiency / Q000150:complications* / Q000453:epidemiology
chemical_list: D014812:Vitamin K