title: Nationwide survey of the development of drug-resistant pathogens in the pediatric field in 2007 and 2010: drug sensitivity of Streptococcus pneumoniae in Japan (second report).
abstract: We previously conducted nationwide surveillance of Streptococcus pneumoniae in 2000-2001 (period 1) and 2004 (period 2) and reported the findings. Subsequent surveillance surveys conducted in 2007 (period 3) and 2010 (period 4) are now reported. Bacterial strains were clinically isolated from children with meningitis, sepsis, and respiratory tract infections at 27 hospitals participating in the Drug-Resistant Pathogen Surveillance Group in Pediatric Infectious Disease. Twenty-one drugs were investigated for 283 isolated strains in period 3, and 24 drugs were investigated for 459 strains in period 4. In period 3, 43.8 % of strains were penicillin-susceptible S. pneumoniae (PSSP), 52.3 % were penicillin-intermediate S. pneumoniae (PISP), and 3.9 % were penicillin-resistant S. pneumoniae (PRSP). In period 4, the percentages were PSSP 23.1 %, PISP 49.9 %, and PRSP 27.0 %. The resistance rates were 56.2 % and 76.9 %, respectively. Drug sensitivity was best with panipenem, at a minimum inhibitory concentration (MIC)90 ≤0.063 μg/ml in period 3, and with tebipenem (MIC90 ≤ 0.063 μg/ml) in period 4. Patients' background factors related to increased bacterial resistance were investigated, and significant differences were found depending on whether a child had siblings (P = 0.0056) or was a daycare center attendee (P = 0.0195) in period 3, and age category (P = 0.0256) in period 4. No factors were common to both periods 3 and 4. Pneumococcus is a major causative organism of pediatric infectious disease, and we plan to continue conducting surveillance and providing information in the future.
authors.affiliation: Department of Pediatrics, Hakujikai Memorial Hospital, 5-11-1 Shikahama, Adachi-ku, Tokyo, Japan. tajima@hakujikai.org
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tajima
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Sato
authors.forename: Yoshikiyo
authors.initials: Y
authors.lastname: Toyonaga
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hanaki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sunakawa
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D062486:Public Health Surveillance; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents
references.citation: Int J Infect Dis. 2002 Mar;6 Suppl 1:S14-20
references.pmid: 12044285
references.citation: Eur J Pediatr. 2006 Jan;165(1):3-8
references.pmid: 16133242
references.citation: Intern Med. 2006;45(7):419-28
references.pmid: 16679695
references.citation: J Infect Chemother. 2009 Dec;15(6):396-401
references.pmid: 20012731