title: Analytical evaluation of GeneXpert CT/NG, the first genetic point-of-care assay for simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis.
abstract: GeneXpert CT/NG was evaluated with 372 characterized bacterial strains. Sensitivity of 10 genome copies/reaction was obtained for both agents. Four Neisseria mucosa and two Neisseria subflava isolates were positive for one of two gonococcal targets; however, the assay flagged all as negative. The assay was analytically highly sensitive and specific.
authors.affiliation: Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia. sepehr.tabrizi@thewomens.org.au
authors.forename: Sepehr N
authors.initials: SN
authors.lastname: Tabrizi
authors.forename: Magnus
authors.initials: M
authors.lastname: Unemo
authors.forename: Daniel
authors.initials: D
authors.lastname: Golparian
authors.forename: Jimmy
authors.initials: J
authors.lastname: Twin
authors.forename: Athena E
authors.initials: AE
authors.lastname: Limnios
authors.forename: Monica
authors.initials: M
authors.lastname: Lahra
authors.forename: Rebecca
authors.initials: R
authors.lastname: Guy
mesh_terms: D001431:Bacteriological Techniques / Q000379:methods*; D002692:Chlamydia trachomatis / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006069:Gonorrhea / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D008219:Lymphogranuloma Venereum / Q000175:diagnosis* / Q000382:microbiology; D008297:Male; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D009344:Neisseria gonorrhoeae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D019095:Point-of-Care Systems; D012680:Sensitivity and Specificity
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