title: Isolation of five new flavonoids from Melicope triphylla.
abstract: Five new flavonoids, 5,8-dihydroxy-3,7-dimethoxy-3',4'-methylenedioxyflavone (1), 7-hydroxy-3,5-dimethoxy-3',4'-methylenedioxyflavone (2), 7-(2,3-dihydroxy-3-methylbutoxy)-3,5-dimethoxy-3',4'-methylenedioxyflavone (3), 7-(2,3-dihydroxy-3-methylbutoxy)-3,3',4',5-tetramethoxyflavone (4), and 7-(2,3-dihydroxy-3-methylbutoxy)-3,3',4',5,8-pentamethoxyflavone (5), were isolated from the leaves of Melicope triphylla. In addition, six known flavonoids were detected: 3,4',5-trihydroxy-3',7,8-trimethoxyflavone (6), 5,7-dihydroxy-3-methoxy-3',4'-methylenedioxyflavone (7), 4',5,7-trihydroxy-3,3'-dimethoxyflavone (8), 4',7-dihydroxy-3,3',5,8-tetramethoxyflavone (9), 4',7-dihydroxy-3,3',5-trimethoxyflavone (10), and 4',5,7-trihydroxy-3,3',8-trimethoxyflavone (11). The new compound structures were determined by spectroscopic methods. Compounds 1-5 did not exhibit any ichthyotoxic activity against Japanese killifish (medaka in Japanese) (Oryzias latipes var.) at 10 ppm.
authors.affiliation: College of Science, University of the Ryukyus, Nishihara, Okinawa, Japan.
authors.forename: Matsutake
authors.initials: M
authors.lastname: Higa
authors.forename: Megumi
authors.initials: M
authors.lastname: Imamura
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Ogihara
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Suzuka
mesh_terms: D000818:Animals; D002855:Chromatography, Thin Layer; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D009990:Oryzias; D018515:Plant Leaves / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D012867:Skin / Q000187:drug effects
chemical_list: D005419:Flavonoids