title: An Advanced, Interactive, High-Performance Liquid Chromatography Simulator and Instructor Resources.
abstract: High-Performance Liquid Chromatography (HPLC) simulation software has long been recognized as an effective educational tool, yet we found that existing HPLC simulators are either too expensive, out-dated, or lack many important features we deemed necessary to make them widely useful for educational purposes. Here we describe a free, open-source HPLC simulator we developed that we believe meets this need. The web-based simulator is uniquely sophisticated, yet accessible to a diverse user group with varied expertise in HPLC. It features intuitive controls and indicators for a wide range of experimental conditions, and it displays a graphical chromatogram to provide immediate feedback when conditions are changed. The simulator can be found at hplcsimulator.org. At that website, we also provide a number of example problem sets that can be used by educators to more easily incorporate the simulator into their curriculum. Comments from students who used the simulator in an undergraduate Analytical Chemistry class were very positive.
authors.affiliation: University of Minnesota, 1970 Folwell Ave., St. Paul MN, 55108.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Boswell
authors.forename: Dwight R
authors.initials: DR
authors.lastname: Stoll
authors.forename: Peter W
authors.initials: PW
authors.lastname: Carr
authors.forename: Megan L
authors.initials: ML
authors.lastname: Nagel
authors.forename: Mark F
authors.initials: MF
authors.lastname: Vitha
authors.forename: Gary A
authors.initials: GA
authors.lastname: Mabbott
keywords: Analytical Chemistry; Chromatography; Computer-Based Learning; Graduate Education; HPLC; Internet / Web-Based Learning; Upper-Division Undergraduate
references.citation: J Chromatogr A. 2000 Dec;903(1-2):41-8
references.pmid: 11153954
references.citation: J Chromatogr A. 2002 Aug 2;965(1-2):175-94
references.pmid: 12236524
references.citation: J Chromatogr A. 2006 Feb 24;1107(1-2):79-87
references.pmid: 16406385