title: Activation of Wnt signaling inhibits the pro-apoptotic role of Notch in gastric cancer cells.
abstract: Notch and Wnt signaling play critical roles in the regulation of development and diseases. Several studies have previously reported that Notch may be a therapeutic target in the treatment of various types of human cancer. In this study, we report that activation of Notch1 inhibits the proliferation of BGC-823 gastric cancer cells. However, the activation of the Wnt/β‑catenin signaling pathway promotes the growth of BGC-823 cells. Furthermore, the combinational activation of the two signaling pathways promotes the proliferation of BGC-823 cells. These data suggest that the activation of Wnt signaling overcomes the pro-apoptotic role of Notch in BGC-823 gastric cancer cells.
authors.affiliation: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, Liaoning 110001, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Juan
authors.initials: J
authors.lastname: Mo
authors.forename: Guizhi
authors.initials: G
authors.lastname: Jia
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Luan
authors.forename: Yifu
authors.initials: Y
authors.lastname: Guan
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D045744:Cell Line, Tumor; D019927:Cyclin E / Q000378:metabolism; D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism; D004318:Doxycycline / Q000494:pharmacology; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D018021:Lithium Chloride / Q000494:pharmacology; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D051881:Receptor, Notch1 / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D000072056:Transcription Factor HES-1; D051153:Wnt Proteins / Q000378:metabolism*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D019927:Cyclin E; D051357:Cyclin-Dependent Kinase 2; D004318:Doxycycline; D018398:Homeodomain Proteins; D018021:Lithium Chloride; D016271:Proto-Oncogene Proteins c-myc; D051881:Receptor, Notch1; D000072056:Transcription Factor HES-1; D051153:Wnt Proteins; C078493:HES1 protein, human