title: Plaque Tissue Components Obtained from De Novo Lesions may Predict Restenosis after Directional Coronary Atherectomy.
abstract: BACKGROUND
  A part of coronary stenotic lesions treated with directional coronary atherectomy (DCA) occur restenosis several months later. Specimens obtained by first DCA, present the histology of culplit lesions and may predict restenosis after PCI.
  
  
  METHODS
  The study group comprised 76 patients (male/female 65/11, age 61 ± 11 years). Restenosis, defined as > 50% stenosis diameter by quantitative cineangiography, was present in 26 patients. The other 50 patients (< 50% stenosis) constitute the "no restenosis" group. Inflammatory cells and other atheroma components were planimetrically quantified as a percentage of total tissue area.
  
  
  RESULTS
  As regards lymphocytes, neutrophils and smooth muscle cells, the grade of amount of cells did not differ between restenosis group and no restenosis group. The amount of obtained arterial media was similar, too. However, the area occupied by macrophages or calcified fragments was significantly larger in restenosis group than no restenosis group. And there was a tendency toward larger area occupied by cholesterol gruel, thrombus and myxomatous extracellular matrix (ECM) in restenosis group.
  
  
  CONCLUSIONS
  Rich macrophages infiltration, calcified fragments, cholesterol rich gruel and myxomatous ECM from primary lesions can be predictors of restenosis after DCA, suggesting a possible role in restenotic process after PCI.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Arakawa
authors.forename: Hatsue
authors.initials: H
authors.lastname: Ishibashi-Ueda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hao
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawamura
keywords: atherosclerosis; directional coronary athelectomy; inflammation; percutaneous coronary intervention; restenosis
references.citation: Clin Invest Med. 1988 Feb;11(1):62-7
references.pmid: 3365883
references.citation: J Am Coll Cardiol. 1991 Feb;17(2):442-8
references.pmid: 1991902
references.citation: Circulation. 2004 Aug 24;110(8):940-7
references.pmid: 15302784
references.citation: Circulation. 1992 Nov;86(5):1394-9
references.pmid: 1423951
references.citation: Am Heart J. 1996 Aug;132(2 Pt 1):428-36
references.pmid: 8701907
references.citation: Circulation. 1996 Jul 1;94(1):35-43
references.pmid: 8964115
references.citation: J Am Coll Cardiol. 2001 Apr;37(5):1271-6
references.pmid: 11300434
references.citation: Circ Res. 2004 May 14;94(9):1158-67
references.pmid: 15142969
references.citation: Jpn Circ J. 1990 Jan;54(1):43-56
references.pmid: 2332932
references.citation: Circulation. 1992 Dec;86(6 Suppl):III47-52
references.pmid: 1424051
references.citation: Arterioscler Thromb Vasc Biol. 1996 Jan;16(1):28-33
references.pmid: 8548422
references.citation: J Am Coll Cardiol. 1992 Nov 1;20(5):1284-93
references.pmid: 1401633
references.citation: Circulation. 2000 Nov 14;102(20):2528-34
references.pmid: 11076828
references.citation: Circulation. 1995 Aug 1;92(3):657-71
references.pmid: 7634481
references.citation: Circ Res. 1995 Sep;77(3):445-65
references.pmid: 7641318
references.citation: Circ Res. 1996 Jan;78(1):38-43
references.pmid: 8603503
references.citation: Coron Artery Dis. 1996 Aug;7(8):573-7
references.pmid: 8922884
references.citation: J Am Coll Cardiol. 1995 Feb;25(2):516-20
references.pmid: 7829808
references.citation: J Am Coll Cardiol. 1992 Nov 1;20(5):1101-10
references.pmid: 1401610
references.citation: Cardiology. 2003;100(2):80-5
references.pmid: 14557694
references.citation: Am Heart J. 2002 Oct;144(4):702-9
references.pmid: 12360168
references.citation: Circulation. 1995 Nov 15;92(10):2995-3005
references.pmid: 7586270
references.citation: Am J Cardiol. 2003 Feb 1;91(3):287-92
references.pmid: 12565084
references.citation: Circulation. 1996 Dec 15;94(12):3098-102
references.pmid: 8989115
references.citation: Circulation. 1995 Mar 1;91(5):1397-402
references.pmid: 7867179
references.citation: Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):326-32
references.pmid: 16339500
references.citation: Heart. 2003 Jul;89(7):773-9
references.pmid: 12807855
references.citation: Circulation. 2004 Feb 10;109(5):634-40
references.pmid: 14769686