title: Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study.
abstract: Adverse effects of prenatal exposure to polychlorinated biphenyl (PCB) congeners on postnatal brain development have been reported in a number of previous studies. However, few studies have examined the effects of prenatal PCB exposure on early social development. The present study sought to increase understanding of the neurotoxicity of PCBs by examining the relationship between PCB congener concentrations in umbilical cord blood and fixation patterns when observing upright and inverted biological motion (BM) at four-months after birth. The development of the ability to recognize BM stimuli is considered a hallmark of socio-cognitive development. The results revealed a link between dioxin-like PCB #118 concentration and fixation pattern. Specifically, four-month-olds with a low-level of prenatal exposure to PCB #118 exhibited a preference for the upright BM over inverted BM, whereas those with a relatively high-level of exposure did not. This finding supports the proposal that prenatal PCB exposure impairs the development of social functioning, and indicates the importance of congener-specific analysis in the risk analysis of the adverse effects of PCB exposure on the brain development.
authors.affiliation: Department of Neurobiology and Behavior, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Doi
authors.forename: Shota
authors.initials: S
authors.lastname: Nishitani
authors.forename: Takashi X
authors.initials: TX
authors.lastname: Fujisawa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nagai
authors.forename: Masaki
authors.initials: M
authors.lastname: Kakeyama
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shinohara
mesh_terms: D002657:Child Development / Q000187:drug effects; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D005260:Female; D005312:Fetal Blood / Q000187:drug effects; D005403:Fixation, Ocular / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D009068:Movement / Q000187:drug effects* / Q000502:physiology; D011078:Polychlorinated Biphenyls / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology* / Q000503:physiopathology
chemical_list: D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls
references.citation: Crit Rev Toxicol. 2006 Oct;36(9):663-94
references.pmid: 17050081
references.citation: Endocr Rev. 1999 Jun;20(3):279-307
references.pmid: 10368772
references.citation: Early Hum Dev. 1993 Jan;31(3):181-93
references.pmid: 8444137
references.citation: Environ Health Perspect. 2003 Mar;111(3):357-576
references.pmid: 12611666
references.citation: Cereb Cortex. 2012 May;22(5):981-95
references.pmid: 21775676
references.citation: J Pediatr. 1988 Dec;113(6):991-5
references.pmid: 3142988
references.citation: Physiol Rev. 2008 Jan;88(1):91-124
references.pmid: 18195084
references.citation: Bull Environ Contam Toxicol. 1995 Jul;55(1):8-13
references.pmid: 7663094
references.citation: N Engl J Med. 1996 Sep 12;335(11):783-9
references.pmid: 8703183
references.citation: Percept Psychophys. 2000 Jul;62(5):889-99
references.pmid: 10997036
references.citation: J Pediatr Ophthalmol Strabismus. 1993 Jan-Feb;30(1):33-8
references.pmid: 8455123
references.citation: Chemosphere. 2008 Feb;70(9):1676-84
references.pmid: 17764717
references.citation: Neurosci Lett. 2003 Jun 19;344(1):41-4
references.pmid: 12781917
references.citation: Int J Hyg Environ Health. 2008 Mar;211(1-2):30-9
references.pmid: 17660003
references.citation: Dev Sci. 2008 Jan;11(1):40-6
references.pmid: 18171365
references.citation: Neurosci Res. 2009 Jul;64(3):317-22
references.pmid: 19428135
references.citation: Sci Total Environ. 2012 Aug 15;432:338-43
references.pmid: 22750179
references.citation: Environ Res. 2011 May;111(4):551-8
references.pmid: 21324443
references.citation: J Pediatr. 2000 Apr;136(4):490-6
references.pmid: 10753247
references.citation: Perception. 1984;13(3):283-6
references.pmid: 6514513
references.citation: Pediatrics. 1996 May;97(5):700-6
references.pmid: 8628610
references.citation: Environ Res. 2010 Oct;110(7):699-704
references.pmid: 20673887
references.citation: Tohoku J Exp Med. 2004 Mar;202(3):227-37
references.pmid: 15065649
references.citation: Lancet. 2001 Nov 10;358(9293):1602-7
references.pmid: 11716887
references.citation: Psychol Sci. 2003 Mar;14(2):151-7
references.pmid: 12661677
references.citation: J Pediatr. 1991 Jul;119(1 Pt 1):58-63
references.pmid: 1906100
references.citation: Environ Res. 2006 Nov;102(3):299-307
references.pmid: 16563369
references.citation: Annu Rev Neurosci. 1995;18:193-222
references.pmid: 7605061
references.citation: J Pediatr. 1990 Jan;116(1):38-45
references.pmid: 2104928
references.citation: Toxicol Sci. 2006 Oct;93(2):223-41
references.pmid: 16829543
references.citation: Environ Res. 2012 Apr;114:47-52
references.pmid: 22421256
references.citation: Neurotoxicology. 2000 Dec;21(6):1029-38
references.pmid: 11233749
references.citation: Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):809-13
references.pmid: 18174333
references.citation: Nature. 2009 May 14;459(7244):257-61
references.pmid: 19329996
references.citation: Perception. 2008;37(9):1399-411
references.pmid: 18986066
references.citation: Environ Health Perspect. 2004 Aug;112(11):1208-12
references.pmid: 15289169
references.citation: Toxicol Sci. 1998 Jan;41(1):49-61
references.pmid: 9520341
references.citation: Science. 1982 Oct 29;218(4571):486-7
references.pmid: 7123249
references.citation: Crit Rev Toxicol. 1994;24(2):87-149
references.pmid: 8037844
references.citation: Dev Med Child Neurol. 2004 Jun;46(6):398-405
references.pmid: 15174531
references.citation: Environ Health Perspect. 2002 Jun;110(6):A325-32
references.pmid: 12055063
references.citation: Perception. 2004;33(6):717-46
references.pmid: 15330366
references.citation: Toxicol Appl Pharmacol. 1990 Oct;106(1):136-44
references.pmid: 2123577
references.citation: Early Hum Dev. 1995 Oct 2;43(2):165-76
references.pmid: 8903761
references.citation: Infant Behav Dev. 2009 Dec;32(4):381-91
references.pmid: 19643502
references.citation: PLoS One. 2012;7(12):e50741
references.pmid: 23251380
references.citation: J Neurol Sci. 2011 Sep 15;308(1-2):9-15
references.pmid: 21679971
references.citation: J Cogn Neurosci. 2004 Sep;16(7):1143-58
references.pmid: 15453970
references.citation: Environ Health. 2010 Aug 23;9:51
references.pmid: 20731829
references.citation: Environ Res. 2012 Jul;116:74-84
references.pmid: 22575326
references.citation: J Environ Health. 2010 Oct;73(3):8-14; quiz 32
references.pmid: 20960982
references.citation: Adv Neonatal Care. 2007 Oct;7(5):230-7
references.pmid: 18049149
references.citation: Curr Biol. 2006 Apr 18;16(8):821-4
references.pmid: 16631591
references.citation: Environ Health Perspect. 2002 Oct;110(10):A593-8
references.pmid: 12361940
references.citation: Eur J Neurosci. 2007 Feb;25(4):909-19
references.pmid: 17331189
references.citation: Toxicol Appl Pharmacol. 1991 Oct;111(1):33-42
references.pmid: 1949034
references.citation: Am J Public Health. 1983 Mar;73(3):293-6
references.pmid: 6401943
references.citation: PLoS One. 2011 Jan 18;6(1):e14552
references.pmid: 21267080
references.citation: Behav Res Methods Instrum Comput. 2004 Nov;36(4):625-9
references.pmid: 15641407
references.citation: Lancet. 1992 Feb 1;339(8788):261-4
references.pmid: 1346280
references.citation: Neurotoxicology. 2011 Dec;32(6):975-80
references.pmid: 21545807
references.citation: J Pediatr. 2002 Jan;140(1):48-56
references.pmid: 11815763