title: Studies on therapeutic effects and pathological features of an antithrombin preparation in septic disseminated intravascular coagulation patients.
abstract: OBJECTIVE
  Few reports have been made on the therapeutic effects as well as pathological features of an antithrombin preparation in patients diagnosed with septic disseminated intravascular coagulation (DIC) by the diagnostic criteria for acute DIC.
  
  
  METHODS
  A total of 88 sepsis patients who had received inpatient hospital care during the period from January 2000 through December 2008 were divided into two groups, an antithrombin group and a non-antithrombin group, to study the outcomes. Furthermore, the relationship between sepsis-related factors and DIC in 44 patients was studied.
  
  
  RESULTS
  The antithrombin group contained 34 patients, and the non-antithrombin group contained 54 patients. The outcomes were significantly better in the antithrombin group. The levels of protein C were low in DIC patients.
  
  
  CONCLUSIONS
  Our results suggest that early administration of antithrombin might improve outcomes of septic DIC patients in the diagnostic criteria for Japanese Association for Acute Medicine acute DIC.
authors.affiliation: Department of Emergency and Critical Care Medicine, Saga University Hospital, Saga, Japan. sakamoy@cc.saga-u.ac.jp
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwamura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yamashita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakashima
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koami
authors.forename: Hisashi
authors.initials: H
authors.lastname: Imahase
authors.forename: Akiko
authors.initials: A
authors.lastname: Goto
authors.forename: Kosuke Chris
authors.initials: KC
authors.lastname: Yamada
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Mashiko
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yokota
mesh_terms: D000368:Aged; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents
keywords: Antithrombin; DIC; sepsis
references.citation: Health Care Financ Rev. 1984;Suppl:91-105
references.pmid: 10311080
references.citation: Crit Care Med. 2006 Mar;34(3):625-31
references.pmid: 16521260
references.citation: J Thromb Haemost. 2006 Jan;4(1):90-7
references.pmid: 16409457
references.citation: N Engl J Med. 2001 Mar 8;344(10):699-709
references.pmid: 11236773
references.citation: Intensive Care Med. 1998 Apr;24(4):336-42
references.pmid: 9609411
references.citation: Thromb Haemost. 2001 Nov;86(5):1327-30
references.pmid: 11816725
references.citation: N Engl J Med. 2012 May 31;366(22):2055-64
references.pmid: 22616830
references.citation: Thromb Haemost. 2008 Dec;100(6):1099-105
references.pmid: 19132236
references.citation: Thromb Res. 2012 Jun;129(6):797-800
references.pmid: 21872299
references.citation: Crit Care Med. 2004 Mar;32(3):858-73
references.pmid: 15090974
references.citation: Shock. 2010 Sep;34 Suppl 1:48-53
references.pmid: 20523271
references.citation: Crit Care Med. 2008 Jan;36(1):296-327
references.pmid: 18158437
references.citation: Blood Coagul Fibrinolysis. 2006 Oct;17(7):521-6
references.pmid: 16988545
references.citation: Intensive Care Med. 1996 Jul;22(7):707-10
references.pmid: 8844239
references.citation: World J Surg. 2002 Mar;26(3):307-13
references.pmid: 11865366
references.citation: Intensive Care Med. 1998 Jul;24(7):663-72
references.pmid: 9722035
references.citation: Clin Appl Thromb Hemost. 2003 Jul;9(3):233-40
references.pmid: 14507112