title: Opaciniols A-C, new terpenoids from Garcinia opaca.
abstract: Three new terpenoids, opaciniols A-C (1-3), were isolated from the barks of Garcinia opaca, together with malabarica-17,21-dien-3β,14-diol (4) and 13βH-malabarica-14,17,21-trien-3β-ol (5). Their structures were determined on the basis of NMR spectroscopic data. 3 and 4 showed moderate cytotoxicity against HL-60 cells.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo, 142-8501, Japan.
authors.forename: Reika
authors.initials: R
authors.lastname: Mori
authors.forename: Alfarius Eko
authors.initials: AE
authors.lastname: Nugroho
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Chin Piow
authors.initials: CP
authors.lastname: Wong
authors.forename: Toshio
authors.initials: T
authors.lastname: Kaneda
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirota
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D029760:Garcinia / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D008517:Phytotherapy; D024301:Plant Bark; D010946:Plants, Medicinal; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes
references.citation: J Nat Prod. 2005 Aug;68(8):1222-5
references.pmid: 16124765
references.citation: Phytochemistry. 2000 Sep;55(2):183-8
references.pmid: 11065293
references.citation: Chemistry. 2010 Sep 3;16(33):9944-62
references.pmid: 20648491
references.citation: J Nat Med. 2012 Jan;66(1):166-76
references.pmid: 21830091
references.citation: J Nat Med. 2008 Apr;62(2):207-10
references.pmid: 18404325
references.citation: J Nat Med. 2012 Jul;66(3):421-7
references.pmid: 22033647
references.citation: Phytochemistry. 2013 Jan;85:161-6
references.pmid: 23022020
references.citation: Phytochemistry. 2011 Feb;72(2-3):290-5
references.pmid: 21168174
references.citation: J Nat Med. 2012 Apr;66(2):350-3
references.pmid: 21830090
references.citation: Org Lett. 2009 Jun 18;11(12):2627-30
references.pmid: 19445469
references.citation: J Nat Prod. 1998 Aug;61(8):1015-6
references.pmid: 9722487
references.citation: J Nat Med. 2013 Jan;67(1):9-16
references.pmid: 22350216
references.citation: J Nat Med. 2012 Jul;66(3):571-5
references.pmid: 22213131
references.citation: Phytochemistry. 2004 Feb;65(4):393-8
references.pmid: 14759530
references.citation: J Nat Med. 2013 Jan;67(1):196-201
references.pmid: 22388972
references.citation: J Nat Prod. 2004 Dec;67(12):2043-7
references.pmid: 15620248
references.citation: J Nat Med. 2013 Jan;67(1):234-9
references.pmid: 22456895
references.citation: Phytother Res. 2009 Aug;23(8):1047-65
references.pmid: 19172667
references.citation: Angew Chem Int Ed Engl. 2004 Dec 10;43(48):6700-3
references.pmid: 15593147
references.citation: J Nat Med. 2013 Jan;67(1):212-6
references.pmid: 22421814
references.citation: J Nat Med. 2012 Jul;66(3):566-70
references.pmid: 22161504