title: Rhodium(III)-catalyzed direct selective C(5)-H oxidative annulations of 2-substituted imidazoles and alkynes by double C-H activation.
abstract: Double C-H activations of C(5)-H and Csp(2)-H of 2-substituted N-vinyl- or arylimidazoles were realized without heteroatom-directing assistance by rhodium(III) catalyst. A subsequent oxidative annulation reaction with alkynes efficiently produced aza-fused heterocycles with high molecular complexity in low to excellent yields.
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Ji-Rong
authors.initials: JR
authors.lastname: Huang
authors.forename: Qian-Ru
authors.initials: QR
authors.lastname: Zhang
authors.forename: Chuan-Hua
authors.initials: CH
authors.lastname: Qu
authors.forename: Xun-Hao
authors.initials: XH
authors.lastname: Sun
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D006571:Heterocyclic Compounds; D007093:Imidazoles; D012238:Rhodium