title: Eliminating the latent HIV reservoir by reactivation strategies: advancing to clinical trials.
abstract: Combination antiretroviral therapy (cART) has transformed HIV from a deadly to a chronic disease, but HIV patients are still burdened with excess morbidity and mortality, long-term toxicities from cART, stigmatization, and insufficient access to cART worldwide. Thus, a cure for HIV would have enormous impact on society as well as the individual. As the complexity and mechanisms of HIV persistence during therapy are being unraveled, new therapeutic targets for HIV eradication are discovered. Substances that activate HIV production in the latently infected cells have recently received much attention. By turning on expression of latent HIV proviruses, reactivation strategies could contribute to the eradication HIV infection. Compounds that are currently being or soon to be tested in clinical trials are emphasized. The results from these trials will provide important clues as to whether or not reactivating strategies could become significant components of a cure for HIV.
authors.affiliation: Department of Infectious Diseases; Aarhus University Hospital; Denmark.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Rasmussen
authors.forename: Martin
authors.initials: M
authors.lastname: Tolstrup
authors.forename: Anni
authors.initials: A
authors.lastname: Winckelmann
authors.forename: Lars
authors.initials: L
authors.lastname: Østergaard
authors.forename: Ole S
authors.initials: OS
authors.lastname: Søgaard
mesh_terms: D019380:Anti-HIV Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055808:Drug Discovery / Q000639:trends; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D014775:Virus Activation / Q000187:drug effects*; D017735:Virus Latency / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents
keywords: HIV; cure; experimental research; histone deacetylase inhibitors; immune modulation
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