title: Long-term growth of children with autoantibody-mediated congenital heart block.
abstract: OBJECTIVE
  To analyse growth of children with and without congenital heart block (CHB) born to anti-Ro/SSA positive mothers from birth to 18 years of age, using a population-based cohort of Swedish CHB patients.
  
  
  METHODS
  Medical records for siblings with (n = 72) and without (n = 60) CHB born 1973-2009 to anti-Ro/SSA positive mothers were retrieved from child healthcare centres and school health services and used to extract data on growth from birth to 18 years.
  
  
  RESULTS
  Compared with reference standards, children with CHB were retarded in weight by 0.75-1.0 SD from birth to 2-3 years of age. Thereafter, the CHB children started to catch up, reaching the reference standards at 9-11 years of age. Pacemaker treatment was not correlated with the catch-up in growth. Individuals with CHB were retarded in both weight and height from birth to 9-11 years of age when compared to siblings without CHB, who did not demonstrate restriction in these measurements.
  
  
  CONCLUSIONS
  Presence of CHB is a more important predictor of growth restriction than maternal rheumatic disease and foetal anti-Ro/SSA exposure. The restriction persists for several years after birth, despite pacemaker treatment, which highlights the importance of follow-up of children with CHB regarding nutrition and growth.
authors.affiliation: Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Amanda
authors.initials: A
authors.lastname: Skog
authors.forename: Håkan
authors.initials: H
authors.lastname: Eliasson
authors.forename: Joanna
authors.initials: J
authors.lastname: Tingström
authors.forename: Henrik
authors.initials: H
authors.lastname: Källberg
authors.forename: Stina
authors.initials: S
authors.lastname: Salomonsson
authors.forename: Sven-Erik
authors.initials: SE
authors.lastname: Sonesson
authors.forename: Marie
authors.initials: M
authors.lastname: Wahren-Herlenius
mesh_terms: D000293:Adolescent; D001327:Autoimmune Diseases / Q000097:blood / Q000503:physiopathology; D016022:Case-Control Studies; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006327:Heart Block / Q000151:congenital* / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood; D012261:Ribonucleoproteins / Q000097:blood; D000099207:SS-A Antigen
chemical_list: D012261:Ribonucleoproteins; D000099207:SS-A Antigen