title: Enriching the interventional vision of cancer with fluorescence and optoacoustic imaging.
abstract: Among several techniques considered for surgical and endoscopic imaging, novel optical methods are evolving as a promising approach for interventional guidance. Pilot clinical applications of fluorescence molecular imaging have demonstrated the benefits of using targeted fluorescent agents in cancer surgery. This premise can be extended broadly to interventional guidance through an increasing number of targeted agents and detection techniques. Beyond epi-illumination fluorescence imaging, optoacoustic (photoacoustic) methods are emerging to offer high-resolution cross-sectional optical imaging through several millimeters to centimeters of depth. We present an overview of key recent developments in optical interventional imaging and outline the potential for a paradigm shift in surgical and endoscopic visualization.
authors.affiliation: Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Munich, Germany.
authors.forename: P Beatriz
authors.initials: PB
authors.lastname: Garcia-Allende
authors.forename: Jürgen
authors.initials: J
authors.lastname: Glatz
authors.forename: Maximilian
authors.initials: M
authors.lastname: Koch
authors.forename: Vasilis
authors.initials: V
authors.lastname: Ntziachristos
mesh_terms: D000818:Animals; D003287:Contrast Media; D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009369:Neoplasms / Q000175:diagnosis*; D061088:Photoacoustic Techniques / Q000379:methods*; D013050:Spectrometry, Fluorescence
chemical_list: D003287:Contrast Media; D005456:Fluorescent Dyes
keywords: endoscopy; fluorescence molecular imaging; fluorescent agents; optoacoustic imaging; photoacoustic imaging; surgery