title: Ibuprofen therapy resulted in significantly decreased tissue bacillary loads and increased survival in a new murine experimental model of active tuberculosis.
abstract: C3HeB/FeJ mice infected with Mycobacterium tuberculosis were used in an experimental animal model mimicking active tuberculosis in humans to evaluate the effect of antiinflammatory agents. No other treatment but ibuprofen was given, and it was administered when the animals' health started to deteriorate. Animals treated with ibuprofen had statistically significant decreases in the size and number of lung lesions, decreases in the bacillary load, and improvements in survival, compared with findings for untreated animals. Because antiinflammatory agents are already on the market, further clinical trials should be done to evaluate this effect in humans as soon as possible, to determine their suitability as coadjuvant tuberculosis treatment.
authors.affiliation: Unitat de Tuberculosi Experimental, Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERES.
authors.forename: Cristina
authors.initials: C
authors.lastname: Vilaplana
authors.forename: Elena
authors.initials: E
authors.lastname: Marzo
authors.forename: Gustavo
authors.initials: G
authors.lastname: Tapia
authors.forename: Jorge
authors.initials: J
authors.lastname: Diaz
authors.forename: Vanesa
authors.initials: V
authors.lastname: Garcia
authors.forename: Pere-Joan
authors.initials: PJ
authors.lastname: Cardona
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D007052:Ibuprofen / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development*; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000893:Anti-Inflammatory Agents; D007052:Ibuprofen
keywords: C3HeB/FeJ mice; active tuberculosis; antiinflammatory agents; bacillary load; ibuprofen; survival; tuberculosis; tuberculosis coadjuvant treatment; tuberculosis treatment