title: A new antiallergic agent that binds to dimerized translationally controlled tumor protein and inhibits allergic symptoms is nontoxic.
abstract: Dimerized translationally controlled tumor protein (dTCTP) plays a role in allergic diseases. A 7-mer peptide, dimerized translationally binding protein 2 (dTBP2), binds to dTCTP and inhibits dTCTP, suggesting that the 7-mer peptide may have therapeutic potential. We assessed the safety of dTBP2 by examining its cytotoxicity to both human bronchial epithelial cells and mice. dTBP2 did not cause cytotoxicity to the epithelial cells in concentrations up to 100 μg/ml. Also, dTBP2 caused no adverse effects upon repeated administration of 50 mg/kg over 24 h to mice. Hence, we conclude that dTBP2 is a safe candidate drug for use in the therapy of allergic diseases.
authors.affiliation: 1College of Pharmacy, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.
authors.forename: M
authors.initials: M
authors.lastname: Kim
authors.forename: Y B
authors.initials: YB
authors.lastname: Jin
authors.forename: K
authors.initials: K
authors.lastname: Lee
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000633:toxicity*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D019281:Dimerization; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010455:Peptides / Q000633:toxicity*; D059551:Toxicity Tests, Subacute; D000090324:Tumor Protein, Translationally-Controlled 1
chemical_list: D018926:Anti-Allergic Agents; D014408:Biomarkers, Tumor; D010455:Peptides; C000715647:TPT1 protein, human; C000715648:Tpt1 protein, mouse; D000090324:Tumor Protein, Translationally-Controlled 1
keywords: Dimerized TCTP; allergy; cytotoxicity; dTBP2; repeated-dose toxicity; safety