title: Adenovirus infections in heart transplantation.
abstract: Adenovirus infections have been associated with significant morbidity and mortality in immunocompromised hosts. The clinical significance of adenovirus disease in heart transplantation is not well-defined; in particular, the significance of adenovirus identification in myocardium remains unclear. Although severe adenovirus disease has been described in heart transplant recipients, adenovirus infections seem to be more frequently associated with increased risk of adverse cardiac events, such as rejection, ventricular dysfunction, coronary vasculopathy, need for retransplantation, and graft loss because of death. Cidofovir is currently considered the standard of treatment for adenovirus disease not responding to reduction of immunosuppression.
authors.affiliation: Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE 68198-5400, USA. dflorescu@unmc.edu.
authors.forename: Diana F
authors.initials: DF
authors.lastname: Florescu
authors.forename: Joong Y
authors.initials: JY
authors.lastname: Kwon
authors.forename: Ioana
authors.initials: I
authors.lastname: Dumitru
mesh_terms: D000258:Adenovirus Infections, Human / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology*; D000998:Antiviral Agents / Q000627:therapeutic use; D000077404:Cidofovir; D003327:Coronary Disease / Q000453:epidemiology; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006084:Graft Rejection / Q000453:epidemiology; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology*; D063065:Organophosphonates / Q000627:therapeutic use; D012307:Risk Factors; D018754:Ventricular Dysfunction / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir