title: Bone metabolism compensates for the delayed growth in small for gestational age neonates.
abstract: The goal of the present study is to investigate the relationship between anthropometric and bone metabolism markers in a sample of neonates and their mothers. A sample of 20 SGA (small for the gestational age), AGA (appropriate for the gestational age) and LGA (large for the gestational age) term neonates and their 20 mothers was analyzed at birth and at exit. Elisa method was used to measure the OPG (Osteoprotegerin), RANK (Receptor activator of nuclear factor-kappaB), RANKL (Receptor activator of nuclear factor-kappaB Ligand), IGF-1 (Insulin-like growth factor 1), IGFBP3 (Insulin-like Growth Factor Binding Protein 3) and Leptin levels. Birth weight and length were positively correlated with RANKL, IGF-1 and IGFBP3 and negatively with the ratio OPG/RANKL. SGA neonates presented lower RANKL values and higher OPG/RANKL ratio while LGA neonates had higher RANK levels than AGA neonates. Positive association was shown between neonatal IGFBP3 and maternal IGF-1 values and between neonatal and maternal RANK values at birth and at exit. These results reveal a remarkable upregulation of OPG/RANKL ratio in SGA neonates, pointing out the role of bone turnover in compensating for the delayed neonatal growth.
authors.affiliation: Department of Nutrition Science and Dietetics,Harokopio University, Athens, Greece. rtenta@hua.gr
authors.forename: Roxane
authors.initials: R
authors.lastname: Tenta
authors.forename: Ifigeneia
authors.initials: I
authors.lastname: Bourgiezi
authors.forename: Evangelos
authors.initials: E
authors.lastname: Aliferis
authors.forename: Magdalini
authors.initials: M
authors.lastname: Papadopoulou
authors.forename: Antonis
authors.initials: A
authors.lastname: Gounaris
authors.forename: Maria
authors.initials: M
authors.lastname: Skouroliakou
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood / Q000254:growth & development* / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D009035:Mothers
chemical_list: D015415:Biomarkers
keywords: IGF-1; Leptin; OPG; RANKL; neonates
references.citation: Clin Exp Obstet Gynecol. 2006;33(4):238-40
references.pmid: 17211974
references.citation: Biochim Biophys Acta. 2004 Sep 20;1704(2):49-57
references.pmid: 15363860
references.citation: J Bone Miner Metab. 2011 Mar;29(2):186-92
references.pmid: 20602129
references.citation: Pediatr Int. 2000 Feb;42(1):31-6
references.pmid: 10703231
references.citation: Endocr Rev. 1999 Dec;20(6):761-87
references.pmid: 10605625
references.citation: Nat Clin Pract Endocrinol Metab. 2006 Jun;2(6):318-27
references.pmid: 16932309
references.citation: Gene. 2005 Nov 21;361:38-56
references.pmid: 16183214
references.citation: Endocrinology. 1992 Sep;131(3):1075-80
references.pmid: 1505451
references.citation: J Clin Endocrinol Metab. 2003 Nov;88(11):5361-5
references.pmid: 14602774
references.citation: Horm Res. 1999 Dec;51(6):277-9
references.pmid: 10640888
references.citation: Nutrition. 2002 Jul-Aug;18(7-8):604-8
references.pmid: 12093439
references.citation: Horm Res Paediatr. 2010;73(5):320-7
references.pmid: 20389101
references.citation: J Endocrinol. 2002 Aug;174(2):353-9
references.pmid: 12176675
references.citation: BJOG. 2010 Jan;117(2):200-11
references.pmid: 19832832
references.citation: Ann N Y Acad Sci. 2006 Dec;1092:385-96
references.pmid: 17308163
references.citation: Arch Biochem Biophys. 2008 May 15;473(2):139-46
references.pmid: 18395508
references.citation: Clin Chem. 2008 Mar;54(3):550-8
references.pmid: 18202160
references.citation: Pediatrics. 2003 Jun;111(6 Pt 1):1253-61
references.pmid: 12777538
references.citation: J Bone Miner Metab. 2001;19(3):195-8
references.pmid: 11368306
references.citation: J Clin Endocrinol Metab. 2002 Sep;87(9):4273-9
references.pmid: 12213884
references.citation: Neonatology. 2009;96(2):132-6
references.pmid: 19365143
references.citation: Eur J Endocrinol. 2009 Sep;161(3):381-9
references.pmid: 19561044