title: Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases.
abstract: Clear cell acanthoma or Degos' acanthoma is a distinct disease concerning its clinical, histopathological, and immunohistochemical features. Its pathologic nature - whether neoplastic or reactive - is still under dispute among researchers. The disease shows a chronic course and often presents with a single papulonodular lesion on the lower limbs of adults. However, cases with multiple lesions, sometimes occurring in an eruptive fashion, and with clear variation in the size and shape of the cutaneous lesions have been reported. So far, five cases in which the lesions were exclusively located in the nipple area have been reported, all in Korean women. Four of these cases mimicked eczema and one, a polypoid nodule. The aim of this article is to present clinical, histopathological, and immunohistochemical features of two additional cases in Brazilian women with similar nipple topography.
authors.affiliation: School of Medicine, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, PA, Brazil.
authors.forename: Rossana Ruth Garcia da
authors.initials: RR
authors.lastname: Veiga
authors.forename: Renata Silva
authors.initials: RS
authors.lastname: Barros
authors.forename: Josie Eiras Bisi dos
authors.initials: JE
authors.lastname: Santos
authors.forename: José Maria de Castro
authors.initials: JM
authors.lastname: Abreu Junior
authors.forename: Maraya de Jesus Semblano
authors.initials: Mde J
authors.lastname: Bittencourt
authors.forename: Mario Fernando Ribeiro de
authors.initials: MF
authors.lastname: Miranda
mesh_terms: D049309:Acanthoma / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D001938:Brazil; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009558:Nipples / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
references.citation: Br J Dermatol. 2000 Apr;142(4):842-4
references.pmid: 10792261
references.citation: Int J Dermatol. 2010 Sep;49(9):1008-11
references.pmid: 20931670
references.citation: Br J Dermatol. 1970 Aug;83(2):248-54
references.pmid: 4916780
references.citation: Hautarzt. 1977 Sep;28(9):456-62
references.pmid: 334692
references.citation: Hautarzt. 1995 Dec;46(12):865-8
references.pmid: 8567273
references.citation: Ann Dermatol Syphiligr (Paris). 1962 Jul-Aug;89:361-71
references.pmid: 14026439
references.citation: Am J Dermatopathol. 2007 Apr;29(2):137-40
references.pmid: 17414434
references.citation: Ann Dermatol. 2010 Aug;22(3):337-40
references.pmid: 20711275
references.citation: Br J Dermatol. 1987 Nov;117(5):569-74
references.pmid: 3318907
references.citation: Am J Dermatopathol. 1985 Dec;7(6):515-27
references.pmid: 4091227
references.citation: Am J Dermatopathol. 2011 Aug;33(6):599-602
references.pmid: 21317609
references.citation: Br J Dermatol. 1999 Nov;141(5):950-1
references.pmid: 10583200
references.citation: Arch Dermatol. 1969 Nov;100(5):559-63
references.pmid: 5350407
references.citation: J Cutan Pathol. 2009 May;36(5):573-7
references.pmid: 19476527
references.citation: Br J Dermatol. 1995 Aug;133(2):186-93
references.pmid: 7547383
references.citation: Am J Dermatopathol. 2010 Dec;32(8):787-93
references.pmid: 20802299
references.citation: Am J Clin Pathol. 1973 Mar;59(3):306-11
references.pmid: 4687348