title: Subjective cognitive decline: self and informant comparisons.
abstract: BACKGROUND
  It is unclear whether self- or informant-based subjective cognition better distinguishes emotional factors from early-stage Alzheimer's disease (AD).
  
  
  METHODS
  Healthy members (n = 447) of the Arizona apolipoprotein E (APOE) cohort and their informants completed the self and informant paired Multidimensional Assessment of Neurodegenerative Symptoms questionnaire (MANS).
  
  
  RESULTS
  Decline on the MANS was endorsed by 30.6% of members and 26.2% of informants. Self- and informant-based decliners had higher scores of psychological distress and slightly lower cognitive scores than nondecliners. Over the next 6.7 years, 20 developed mild cognitive impairment (MCI). Converters were older at entry than nonconverters (63.8 [7.0] vs 58.8 [7.3] years, P = .003), 85% were APOE ε4 carriers (P < .0001), and they self-endorsed decline earlier than informants (58.9 [39.2] vs 28.0 [40.4] months before MCI; P = .002).
  
  
  CONCLUSIONS
  Self- and informant-based subjective decline correlated with greater psychological distress and slightly lower cognitive performance. Those with incident MCI generally self-endorsed decline earlier than informants.
authors.affiliation: Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA. Electronic address: caselli.richard@mayo.edu.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Caselli
authors.affiliation: Banner Alzheimer's Institute, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Kewei
authors.initials: K
authors.lastname: Chen
authors.affiliation: Division of Psychology, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Dona E C
authors.initials: DE
authors.lastname: Locke
authors.affiliation: Banner Alzheimer's Institute, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Wendy
authors.initials: W
authors.lastname: Lee
authors.affiliation: Banner Alzheimer's Institute, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Auttawut
authors.initials: A
authors.lastname: Roontiva
authors.affiliation: Banner Alzheimer's Institute, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Bandy
authors.affiliation: Banner Alzheimer's Institute, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Adam S
authors.initials: AS
authors.lastname: Fleisher
authors.affiliation: Banner Alzheimer's Institute, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Reiman
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology*; D015331:Cohort Studies; D056344:Executive Function; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D057566:Self Report; D012720:Severity of Illness Index; D013028:Space Perception / Q000502:physiology; D011795:Surveys and Questionnaires; D014706:Verbal Learning
chemical_list: D001057:Apolipoproteins E
keywords: Cognitive aging; Mild cognitive impairment; Preclinical Alzheimer's disease; Subjective cognition
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