title: Total syntheses of the proposed structure for ieodoglucomides A and B.
abstract: The first enantioselective total synthesis of new glycolipopeptides, ieodoglucomides A and B, has been accomplished along with synthetic elaboration to their C14-epimers starting from d-glucose using β-glycosylation and Grubbs olefin cross-metathesis reactions as the key steps. The present synthetic study has indicated the ambiguity in proposed absolute stereochemistry for the natural product.
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. rajireddy@iict.res.in
authors.forename: Chada Raji
authors.initials: CR
authors.lastname: Reddy
authors.forename: Enukonda
authors.initials: E
authors.lastname: Jithender
authors.forename: Kothakonda Rajendra
authors.initials: KR
authors.lastname: Prasad
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D006001:Glycoconjugates; C572529:ieodoglucomide A; C572530:ieodoglucomide B