title: A two-year randomized controlled trial of progressive resistance exercise for Parkinson's disease.
abstract: The effects of progressive resistance exercise (PRE) on the motor signs of Parkinson's disease have not been studied in controlled trials. The objective of the current trial was to compare 6-, 12-, 18-, and 24-month outcomes of patients with Parkinson's disease who received PRE with a stretching, balance, and strengthening exercise program. The authors conducted a randomized controlled trial between September 2007 and July 2011. Pairs of patients matched by sex and off-medication scores on the Unified Parkinson's Disease Rating Scale, motor subscale (UPDRS-III), were randomly assigned to the interventions with a 1:1 allocation ratio. The PRE group performed a weight-lifting program. The modified fitness counts (mFC) group performed a stretching, balance, and strengthening exercise program. Patients exercised 2 days per week for 24 months at a gym. A personal trainer directed both weekly sessions for the first 6 months and 1 weekly session after 6 months. The primary outcome was the off-medication UPDRS-III score. Patients were followed for 24 months at 6-month intervals. Of 51 patients, 20 in the PRE group and 18 in the mFC group completed the trial. At 24 months, the mean off-medication UPDRS-III score decreased more with PRE than with mFC (mean difference, -7.3 points; 95% confidence interval, -11.3 to -3.6; P<0.001). The PRE group had 10 adverse events, and the mFC group had 7 adverse events. PRE demonstrated a statistically and clinically significant reduction in UPDRS-III scores compared with mFC and is recommended as a useful adjunct therapy to improve Parkinsonian motor signs. © 2013 Movement Disorder Society.
authors.affiliation: Department of Kinesiology and Nutrition, University of Illinois, Chicago, IL, USA. dcorcos@uic.edu
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Corcos
authors.forename: Julie A
authors.initials: JA
authors.lastname: Robichaud
authors.forename: Fabian J
authors.initials: FJ
authors.lastname: David
authors.forename: Sue E
authors.initials: SE
authors.lastname: Leurgans
authors.forename: David E
authors.initials: DE
authors.lastname: Vaillancourt
authors.forename: Cynthia
authors.initials: C
authors.lastname: Poon
authors.forename: Miriam R
authors.initials: MR
authors.lastname: Rafferty
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Kohrt
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Comella
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009068:Movement / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology; D017063:Outcome Assessment, Health Care; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013997:Time Factors
keywords: Parkinson's disease; Unified Parkinson's Disease Rating Scale motor subscale; progressive resistance exercise; randomized controlled trial; strength training
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