title: Neuroimaging in children, adolescents and young adults with psychological trauma.
abstract: Childhood psychological trauma is a strong predictor of psychopathology. Preclinical research points to the influence of this type of trauma on brain development. However, the effects of psychological trauma on the developing human brain are less known and a challenging question is whether the effects can be reversed or even prevented. The aim of this review is to give an overview of neuroimaging studies in traumatized juveniles and young adults up till 2012. Neuroimaging studies in children and adolescents with traumatic experiences were found to be scarce. Most studies were performed by a small number of research groups in the United States and examined structural abnormalities. The reduction in hippocampal volume reported in adults with PTSD could not be confirmed in juveniles. The most consistent finding in children and adolescents, who experienced psychological trauma are structural abnormalities of the corpus callosum. We could not identify any studies investigating treatment effects. Neuroimaging studies in traumatized children and adolescents clearly lag behind studies in traumatized adults as well as studies on ADHD and autism.
authors.affiliation: Academic Centre for Child and Adolescent Psychiatry, Curium-LUMC, Endegeesterstraatweg 27, 2342 AK, Oegstgeest, The Netherlands, m.a.w.rinne@curium.nl.
authors.forename: Mirjam A W
authors.initials: MA
authors.lastname: Rinne-Albers
authors.forename: Nic J A
authors.initials: NJ
authors.lastname: van der Wee
authors.forename: Francien
authors.initials: F
authors.lastname: Lamers-Winkelman
authors.forename: Robert R J M
authors.initials: RR
authors.lastname: Vermeiren
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D008297:Male; D013313:Stress Disorders, Post-Traumatic / Q000523:psychology*; D014481:United States
references.citation: Depress Anxiety. 2002;16(1):14-38
references.pmid: 12203669
references.citation: Biol Psychiatry. 2009 Oct 1;66(7):642-8
references.pmid: 19560122
references.citation: J Psychiatr Res. 2007 Aug;41(5):435-45
references.pmid: 16445942
references.citation: Biol Psychiatry. 2002 Dec 1;52(11):1066-78
references.pmid: 12460690
references.citation: Biol Psychiatry. 2010 Nov 1;68(9):832-8
references.pmid: 20692648
references.citation: Neuroimage. 2012 Jan 16;59(2):1071-9
references.pmid: 21985907
references.citation: Biol Psychiatry. 2000 Oct 15;48(8):778-90
references.pmid: 11063974
references.citation: Am J Psychiatry. 2002 Aug;159(8):1265-83
references.pmid: 12153816
references.citation: Neuroimaging Clin N Am. 2007 Nov;17(4):495-509, ix
references.pmid: 17983966
references.citation: Depress Anxiety. 2008;25(6):514-26
references.pmid: 17598145
references.citation: Hum Brain Mapp. 2010 Jun;31(6):904-16
references.pmid: 20496381
references.citation: Eur Psychiatry. 2010 Oct;25(6):345-54
references.pmid: 20620025
references.citation: Psychiatry Res. 2004 Sep 15;131(3):227-35
references.pmid: 15465292
references.citation: Biol Psychiatry. 2003 May 1;53(9):796-808
references.pmid: 12725972
references.citation: Curr Psychiatry Rep. 2012 Jun;14(3):197-202
references.pmid: 22460663
references.citation: Br J Psychiatry. 2010 Nov;197(5):378-85
references.pmid: 21037215
references.citation: Dev Psychopathol. 2001 Summer;13(3):473-89
references.pmid: 11523844
references.citation: Pediatrics. 2007 Mar;119(3):509-16
references.pmid: 17332204
references.citation: Psychol Med. 2008 Apr;38(4):555-61
references.pmid: 18005496
references.citation: Science. 2011 Aug 19;333(6045):982-3
references.pmid: 21852492
references.citation: Neuroimage. 2011 Jan;54 Suppl 1:S280-6
references.pmid: 20483374
references.citation: J Child Psychol Psychiatry. 2009 Aug;50(8):943-51
references.pmid: 19457047
references.citation: J Neuropsychiatry Clin Neurosci. 2008 Summer;20(3):292-301
references.pmid: 18806232
references.citation: Dev Psychopathol. 2008 Fall;20(4):1133-43
references.pmid: 18838034
references.citation: Biol Psychiatry. 1999 May 15;45(10):1271-84
references.pmid: 10349033
references.citation: Psychiatry Clin Neurosci. 2009 Feb;63(1):1-8
references.pmid: 19154207
references.citation: J Trauma Stress. 2001 Oct;14(4):835-41
references.pmid: 11776428
references.citation: Psychiatry Res. 2008 Apr 15;162(3):256-61
references.pmid: 18296031
references.citation: Hippocampus. 2008;18(8):729-36
references.pmid: 18446827
references.citation: Biol Psychiatry. 2001 Aug 15;50(4):305-9
references.pmid: 11522266
references.citation: Biol Psychiatry. 2003 Oct 1;54(7):693-702
references.pmid: 14512209
references.citation: J Pediatr Psychol. 2010 Jun;35(5):559-69
references.pmid: 19995868
references.citation: Depress Anxiety. 2006;23(1):17-25
references.pmid: 16247760
references.citation: Am J Psychiatry. 2001 Nov;158(11):1878-83
references.pmid: 11691695
references.citation: Neurosci Biobehav Rev. 2006;30(7):1004-31
references.pmid: 16730374
references.citation: J Psychiatr Res. 2010 May;44(7):477-85
references.pmid: 19942229
references.citation: Dev Psychopathol. 2001 Summer;13(3):419-49
references.pmid: 11523842
references.citation: Biol Psychiatry. 2009 Feb 1;65(3):227-34
references.pmid: 18692174
references.citation: Neurosci Lett. 2004 Nov 3;370(1):13-8
references.pmid: 15489009
references.citation: J Nerv Ment Dis. 2007 Dec;195(12):1027-9
references.pmid: 18091198
references.citation: Biol Psychiatry. 2004 Apr 1;55(7):752-8
references.pmid: 15039005
references.citation: Psychol Sci. 2007 Feb;18(2):127-9
references.pmid: 17425531
references.citation: J Child Psychol Psychiatry. 2010 Oct;51(10):1079-95
references.pmid: 20546078
references.citation: Biol Psychiatry. 2004 Jul 15;56(2):80-5
references.pmid: 15231439
references.citation: Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):103-17
references.pmid: 12732227
references.citation: Biol Psychiatry. 2006 Mar 15;59(6):523-9
references.pmid: 16199014
references.citation: J Psychiatr Res. 2011 Dec;45(12):1627-33
references.pmid: 21824628
references.citation: Ann N Y Acad Sci. 2010 Oct;1208:142-9
references.pmid: 20955336
references.citation: Psychiatr Clin North Am. 2002 Jun;25(2):397-426, vii-viii
references.pmid: 12136507
references.citation: Nat Neurosci. 2002 Nov;5(11):1242-7
references.pmid: 12379862
references.citation: Am J Prev Med. 1998 May;14(4):245-58
references.pmid: 9635069
references.citation: J Pediatr Psychol. 2010 Jun;35(5):570-7
references.pmid: 20008084
references.citation: Neuroimage. 2009 Aug;47 Suppl 2:T66-71
references.pmid: 19285558
references.citation: J Neurosci. 2010 Jun 2;30(22):7466-72
references.pmid: 20519521
references.citation: Biol Psychiatry. 2006 Oct 1;60(7):697-703
references.pmid: 16934769
references.citation: J Child Psychol Psychiatry. 2007 Jul;48(7):631-48
references.pmid: 17593144
references.citation: Sci Am. 2002 Mar;286(3):68-75
references.pmid: 11857902
references.citation: Pediatrics. 2006 Jun;117(6):2093-100
references.pmid: 16740852
references.citation: Clin Psychol Rev. 2008 Feb;28(2):228-46
references.pmid: 17602811
references.citation: Psychiatry Res. 2009 Jun 30;172(3):226-34
references.pmid: 19349151
references.citation: Neuroimaging Clin N Am. 2007 Nov;17(4):523-38, ix
references.pmid: 17983968
references.citation: Biol Psychiatry. 2001 Dec 15;50(12):943-51
references.pmid: 11750890