title: Is human cytomegalovirus associated with breast cancer progression?
abstract: BACKGROUND
  It has been hypothesized that human cytomegalovirus (HCMV) may be associated with breast cancer progression. However, the role of HCMV infection in breast cancer remains controversial. We aimed to assess whether HCMV genes (UL122 and UL83) could be detected in breast carcinomas and reinvestigated their possible association with breast cancer progression. DNA from paraffin-embedded tissues was analyzed by real-time PCR. We investigated 20 fibroadenomas and 27 primary breast carcinomas (stages II, III, and IV).
  
  
  RESULTS
  Two carcinomas were positive for HCMV, one was positive for two TaqMan viral detection probes, and one was positive for a sole TaqMan viral detection probe (UL83), whereas the remainder of the samples was negative.
  
  
  CONCLUSIONS
  Samples studied showed no association between HCMV infection and breast cancer progression.
authors.affiliation: Medical Research Unit in Human Genetics, Pediatrics Hospital, XXI Century National Medical Center, Mexican Social Security Institute, Mexico City, 06720, Mexico. mertachiquin@yahoo.com.mx.
authors.forename: Dolores
authors.initials: D
authors.lastname: Utrera-Barillas
authors.forename: Hilda-Alicia
authors.initials: HA
authors.lastname: Valdez-Salazar
authors.forename: David
authors.initials: D
authors.lastname: Gómez-Rangel
authors.forename: Isabel
authors.initials: I
authors.lastname: Alvarado-Cabrero
authors.forename: Penélope
authors.initials: P
authors.lastname: Aguilera
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gómez-Delgado
authors.forename: Martha-Eugenia
authors.initials: ME
authors.lastname: Ruiz-Tachiquin
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