title: Coeliac disease in a 15-year period of observation (1997 and 2011) in a Hungarian referral centre.
abstract: OBJECTIVE
  The aim of this study is to evaluate the experience of a single coeliac centre over a 15-year-long study period (between November of 1997 and September of 2011).
  
  
  METHODS
  Charts of 178 patients (139 females) with coeliac disease were retrospectively evaluated. Tests performed: multiple duodenal biopsies, anti-tissue transglutaminase and anti-endomysium antibodies, body mass index calculation, osteodensitometry, evaluation of disorders associated with coeliac disease, and implementation of family screening.
  
  
  RESULTS
  Histological samples were available in 133 cases, distribution according to Marsh-Oberhuber classification: M0 in 7%, M1-M2 in 4%, M3a in 26%, M3b in 13%, and M3c in 50% of cases, respectively. Anti-tissue transglutaminase and anti-endomysium antibody tests were available in 158 cases, 132/158 showed seropositivity. Mean body mass index values were 23.05kg/m(2) for males, and 21.07kg/m(2) for females, respectively. Osteodensitometry showed normal values in 46%, osteopenia in 36%, and osteoporosis in 18% of cases, respectively. Coeliac disease associated disorders was present in 63/178 (35%) patients. Ninety coeliacs brought 197 first degree relatives for screening, with 47/197 (23%) relatives proving to have coeliac disease. Correlations between anti-tissue transglutaminase antibody titres and Marsh-Oberhuber classification, and anti-tissue transglutaminase antibody titres and bone mineral density values were found to be statistically significant (p=0.0011, and p=0.001, respectively).
  
  
  CONCLUSIONS
  Coeliac disease can become overt at any age. Female predominance is significant. Histology usually showed advanced villous atrophy. Mean body mass index values were within normal range. The high prevalence of associated disorders is also noted. The prevalence of 24% of coeliac disease among first degree relatives underlines the necessity of family screening.
authors.affiliation: Semmelweis University, 2nd Dept. Med., Budapest, Hungary.
authors.forename: Dorottya
authors.initials: D
authors.lastname: Kocsis
authors.forename: Pál
authors.initials: P
authors.lastname: Miheller
authors.forename: Katalin
authors.initials: K
authors.lastname: Lőrinczy
authors.forename: László
authors.initials: L
authors.lastname: Herszényi
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Tulassay
authors.forename: Károly
authors.initials: K
authors.lastname: Rácz
authors.forename: Márk
authors.initials: M
authors.lastname: Juhász
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001706:Biopsy; D002446:Celiac Disease / Q000453:epidemiology* / Q000473:pathology*; D004386:Duodenum / Q000473:pathology*; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012017:Referral and Consultation / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D017678:Sex Distribution; D011503:Transglutaminases / Q000235:genetics; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins