title: Pattern recognition receptor function in neutrophils.
abstract: Previously, neutrophils were largely ignored in the pattern recognition receptor (PRR) signaling field. However, interest in neutrophil biology has been revitalized by emerging roles for neutrophils in promoting protective and pathogenic T helper (Th)17-driven immune responses and in orchestrating innate and adaptive immunity via cytokine/chemokine production. Although it was originally assumed that neutrophils are transcriptionally inert and their short lifespan limits their ability to respond to PRR agonists, the past 5 years has seen tremendous advances in neutrophil PRR signaling that have shifted this paradigm. Here, we review recent findings that demonstrate that neutrophils express a broad repertoire of PRRs, respond dynamically to their stimulation during infection and inflammation, and that neutrophil PRRs are key regulators of in vivo host immune responses.
authors.affiliation: Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
authors.forename: Christina J
authors.initials: CJ
authors.lastname: Thomas
authors.forename: Kate
authors.initials: K
authors.lastname: Schroder
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D018925:Chemokines / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D018836:Inflammation Mediators / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D018925:Chemokines; D018836:Inflammation Mediators; D051192:Receptors, Pattern Recognition