title: Real-time magnetic resonance imaging visualization and quantitative assessment of diffusion in the cerebral extracellular space of C6 glioma-bearing rats.
abstract: Interstitial drug delivery is a promising technique for glioma treatment; however, suboptimal methodologies limit the ability to document the delivery of therapeutic agents. The present study employed magnetic resonance imaging for real-time visualization and quantitative assessment of drug diffusion in gliomas. Using gadolium-diethylenetriaminepentaacetic acid (Gd-DTPA) as a tracer, we considered diffusion in the agarose gel phantom as a reference and compared the diffusion and distribution patterns between the control group and C6 glioma-bearing rats after direct cerebral infusion. Our findings confirmed that Gd-DTPA diffusion was severely impaired in gliomas and presented in an anisotropic pattern in the caudate nucleus. The proposed method provides a new approach for the real-time monitoring of interstitial drug delivery and quantitative assessment of biophysical structural variations in diseased tissue.
authors.affiliation: Department of Radiology, Peking University Third Hospital, Beijing, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.forename: Hongbin
authors.initials: H
authors.lastname: Han
authors.forename: Kai
authors.initials: K
authors.lastname: Zhu
authors.forename: Kejia
authors.initials: K
authors.lastname: Lee
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Fugen
authors.initials: F
authors.lastname: Zhou
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
authors.forename: Qingyuan
authors.initials: Q
authors.lastname: He
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D016543:Central Nervous System Neoplasms / Q000378:metabolism*; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005910:Glioma / Q000378:metabolism*; D057967:Infusions, Intraventricular; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D008297:Male; D009368:Neoplasm Transplantation; D019047:Phantoms, Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA