title: Subacute cystic expansion of intracranial juvenile psammomatoid ossifying fibroma.
abstract: Juvenile psammomatoid ossifying fibroma (JPOF) is a benign fibro-osseous lesion typically associated with the jaw, paranasal region, or orbit. However, JPOF may also originate from the skull base and locally invade the cranium. In published reports, intracranial JPOFs constitute only a small percentage of cases, and therefore it is not known whether more aggressive behavior typifies this distinct population of JPOFs compared with those in other locations. Nevertheless, JPOF histopathology is characterized by a number of active processes, including cystic transformation, that may precipitate violation of skull base boundaries. In the following article, the authors present a case of skull base JPOF that underwent cystic expansion in a young girl, produced a focal neurological deficit, and was resolved using a staged surgical approach.
authors.affiliation: Brain Tumor Center, Department of Neurological Surgery, University of California-SanFrancisco, 505 Parnassus Avenue, San Francisco, CA 94143-0112, USA. rowlandn@neurosurg.ucsf.edu
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Rowland
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Jermakowicz
authors.forename: Tarik
authors.initials: T
authors.lastname: Tihan
authors.forename: Ivan H
authors.initials: IH
authors.lastname: El-Sayed
authors.forename: Michael W
authors.initials: MW
authors.lastname: McDermott
mesh_terms: D020434:Abducens Nerve Diseases / Q000209:etiology; D000293:Adolescent; D001845:Bone Cysts / Q000209:etiology*; D005260:Female; D018214:Fibroma, Ossifying / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D044583:Neuroendoscopy / Q000379:methods; D009666:Nose; D012888:Skull Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome; D014786:Vision Disorders / Q000209:etiology