title: Effects of antiplatelet agents and other factors on neointimal proliferation in iliac artery stenting: intravascular ultrasound analysis.
abstract: OBJECTIVE
  To use intravascular ultrasound to investigate the effects of antiplatelet agents and other factors on neointimal proliferation after stent implantation for iliac artery stenosis.
  
  
  METHODS
  The subjects were 109 patients with peripheral arterial disease who underwent stent implantation in the iliac artery. Intravascular ultrasound was performed to evaluate lesion area, stent dilatation and neointimal proliferation before, just after, and six months after stenting. Multiple regression analysis was performed to examine the relationship of the neointimal proliferation rate with antiplatelet agents and other factors.
  
  
  RESULTS
  At the time of stent implantation, a Palmaz stent resulted in a significant increase in lumen area compared with a Wallstent (p < 0.05). Six months later, self-expanding Wallstent and Luminexx stents showed a significant increase in the stent-lumen area (p < 0.05). The neointimal proliferation rate showed a significant negative correlation with beraprost and cilostazol (p < 0.05) and a significant positive correlation with serum creatinine (p < 0.01). There was no significant difference in the vessel lumen area including the proliferated intima among the three stents.
  
  
  CONCLUSIONS
  Suppression of neointimal proliferation can be achieved with beraprost or cilostazol whereas renal dysfunction may increase neointimal proliferation following stent implantation in iliac artery lesions.
authors.affiliation: Department of Vascular Medicine, Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular Hospital), Gunma, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Kumakura
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kanai
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Araki
authors.forename: Akira
authors.initials: A
authors.lastname: Koizumi
authors.forename: Shu
authors.initials: S
authors.lastname: Kasama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sumino
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ichikawa
keywords: beraprost; iliac artery; neointimal proliferation; peripheral arterial disease; stent implantation
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