title: Interleukin receptor family member ST2 concentrations in patients following heart transplantation.
abstract: OBJECTIVE
  To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT).
  
  
  METHODS
  sST2 concentrations were measured in 241 patients following OHT.
  
  
  RESULTS
  Elevated sST2 was associated with cellular rejection (CR) ≥ 1R, with highest rates of CR in the 4th sST2 quartile (p = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥ 30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15-3.51; p = 0.01).
  
  
  CONCLUSIONS
  Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT.
authors.affiliation: Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA. jjanuzzi@partners.org
authors.forename: James L
authors.initials: JL
authors.lastname: Januzzi
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Horne
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Moore
authors.forename: Oxana
authors.initials: O
authors.lastname: Galenko
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Snow
authors.forename: Kimberly D
authors.initials: KD
authors.lastname: Brunisholz
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Muhlestein
authors.forename: Rami
authors.initials: R
authors.lastname: Alharethi
authors.forename: John F
authors.initials: JF
authors.lastname: Carlquist
authors.forename: Deborah
authors.initials: D
authors.lastname: Budge
authors.forename: Kismet
authors.initials: K
authors.lastname: Rasmussen
authors.forename: Abdallah G
authors.initials: AG
authors.lastname: Kfoury
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D016027:Heart Transplantation; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000097:blood*; D016019:Survival Analysis; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011956:Receptors, Cell Surface