title: Platelet activity in Chinese obese adolescents with and without insulin resistance.
abstract: To investigate the platelet activity in Chinese obese adolescents with and without insulin resistance. A cross-sectional study was performed in 159 obese Chinese adolescents to investigate their platelet activity using anthropometrics and biochemical parameters, oral glucose tolerance test and platelet testing. An index of insulin sensitivity, homeostasis model assessment of insulin resistance (HOMA-IR), and plasma fibrinogen, prothrombin fragment 1.2 (PT 1.2), fibrinopeptide A (FPA) and the levels of aggregation to collagen 1 μg/ml, adenosine diphosphate (ADP) 10 μmol/L and arachidonic acid (AA) 0.5 mmol/L were measured. Obese adolescents with insulin resistance had significantly higher HOMA-IR, glucose response curve (AUC), insulin AUC, PT 1.2, FPA and fibrinogen and aggregation (to collagen 1 μg/ml, ADP 10 μmol/L and AA 0.5 mmol/L) comparison with obese adolescents without insulin resistance (P < 0.05). Moreover, a positive correlation was found between both aggregation (to collagen, ADP and AA) and HOMA-IR (ρ = 0.716; P < 0.01, ρ = 0.682; P < 0.01 and ρ = 0.699; P < 0.01, respectively), glucose AUC (ρ = 0.479; P < 0.01, ρ = 0.416; P < 0.01 and ρ = 0.458; P < 0.01, respectively) and insulin AUC (ρ = 0.585; P < 0.01, ρ = 0.511; P < 0.01 and ρ = 0.576; P < 0.01, respectively) in obese adolescents with insulin resistance. Insulin resistance is a major determinant of platelet activation in Chinese obese adolescents.
authors.affiliation: Department of Hepatobiliopancreatic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Lu
authors.forename: Shundong
authors.initials: S
authors.lastname: Lei
authors.forename: Jiuming
authors.initials: J
authors.lastname: Zhao
authors.forename: Ni
authors.initials: N
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D002681:China; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood* / Q000473:pathology; D010974:Platelet Aggregation
chemical_list: D001786:Blood Glucose; D007328:Insulin
references.citation: Circulation. 2003 Mar 18;107(10):1448-53
references.pmid: 12642369
references.citation: N Engl J Med. 1992 Nov 5;327(19):1350-5
references.pmid: 1406836
references.citation: Diabetes. 1988 Jun;37(6):780-6
references.pmid: 2838353
references.citation: J Clin Endocrinol Metab. 2005 Jun;90(6):3145-52
references.pmid: 15755862
references.citation: N Engl J Med. 1990 May 31;322(22):1549-54
references.pmid: 2336086
references.citation: Pediatrics. 1998 Sep;102(3):E29
references.pmid: 9724677
references.citation: Circulation. 1991 Aug;84(2):613-7
references.pmid: 1860204
references.citation: J Clin Invest. 2000 Aug;106(4):473-81
references.pmid: 10953022
references.citation: Obes Rev. 2012 Jan;13(1):27-42
references.pmid: 21917110
references.citation: J Intern Med. 2007 Aug;262(2):157-72
references.pmid: 17645584
references.citation: Diabetes. 1995 Nov;44(11):1318-22
references.pmid: 7589830
references.citation: Horm Res. 2001;55 Suppl 1:42-5
references.pmid: 11408761
references.citation: Diabetes. 1997 May;46(5):742-9
references.pmid: 9133539
references.citation: Metabolism. 1996 Feb;45(2):235-40
references.pmid: 8596496
references.citation: Am J Clin Nutr. 1998 Jun;67(6):1111-8
references.pmid: 9625081
references.citation: Biochem Biophys Res Commun. 1988 Dec 30;157(3):1190-6
references.pmid: 2849932
references.citation: Diabetes Care. 1999 Sep;22(9):1462-70
references.pmid: 10480510
references.citation: J Am Coll Cardiol. 2006 Dec 19;48(12):2531-8
references.pmid: 17174194
references.citation: J Clin Invest. 2006 Jul;116(7):1793-801
references.pmid: 16823477
references.citation: Circulation. 2001 Jul 10;104(2):181-6
references.pmid: 11447083
references.citation: J Clin Endocrinol Metab. 2004 Jun;89(6):2540-7
references.pmid: 15181021
references.citation: Fertil Steril. 2000 Jan;73(1):150-6
references.pmid: 10632431
references.citation: Diabetes Care. 2009 May;32(5):944-9
references.pmid: 19228864
references.citation: Am J Clin Nutr. 2002 Jun;75(6):971-7
references.pmid: 12036801