title: Cytotoxic, antitopoisomerase IIα, and anti-HIV-1 activities of triterpenoids isolated from leaves and twigs of Gardenia carinata.
abstract: Eight new cycloartane triterpenoids (1-8), named carinatins A-H, and the known compounds secaubryolide (9) and dikamaliartane D (10) were isolated from the leaves and twigs of Gardenia carinata. Their structures were determined on the basis of spectroscopic methods. Cytotoxic, antitopoisomerase IIα, and anti-HIV-1 activities of compounds 1-7, 9, and 10 were investigated.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand.
authors.forename: Naowarat
authors.initials: N
authors.lastname: Kongkum
authors.forename: Patoomratana
authors.initials: P
authors.lastname: Tuchinda
authors.forename: Manat
authors.initials: M
authors.lastname: Pohmakotr
authors.forename: Vichai
authors.initials: V
authors.lastname: Reutrakul
authors.forename: Pawinee
authors.initials: P
authors.lastname: Piyachaturawat
authors.forename: Surawat
authors.initials: S
authors.lastname: Jariyawat
authors.forename: Kanoknetr
authors.initials: K
authors.lastname: Suksen
authors.forename: Radeekorn
authors.initials: R
authors.lastname: Akkarawongsapat
authors.forename: Jitra
authors.initials: J
authors.lastname: Kasisit
authors.forename: Chanita
authors.initials: C
authors.lastname: Napaswad
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D032062:Gardenia / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013785:Thailand; D059005:Topoisomerase II Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D059005:Topoisomerase II Inhibitors; D014315:Triterpenes; C516507:secaubryolide; C085352:cycloartane