title: Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population.
abstract: BACKGROUND
  A recent genome-wide association study has identified a new genetic variant rs7758229 in SLC22A3 for colorectal cancer susceptibility in a Japanese population, but it is unknown whether this newly identified variant is associated with colorectal cancer in other populations, including the Chinese population.
  
  
  METHODS
  We examined the associations between rs7758229 and colorectal cancer risk among 1,147 cases and 1,203 controls matched by age and sex. Logistic regression model was used to assess the associations.
  
  
  RESULTS
  No significant association was found between rs7758229 and colorectal cancer risk (OR = 0.95, 95%CI = 0.84-1.09, P = 0.463). Similar results were observed in the stratification of tumor location (OR = 0.94, 95%CI = 0.80-1.11, P = 0.481 for colon cancer, and OR = 0.96, 95%CI = 0.82-1.13, P = 0.621 for rectum cancer).
  
  
  CONCLUSIONS
  Our findings did not support an association between rs7758229 in 6q26-q27 and the risk of colorectal cancer in a Chinese population.
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Lingjun
authors.initials: L
authors.lastname: Zhu
authors.forename: Mulong
authors.initials: M
authors.lastname: Du
authors.forename: Dongying
authors.initials: D
authors.lastname: Gu
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chu
authors.forename: Na
authors.initials: N
authors.lastname: Tong
authors.forename: Jinfei
authors.initials: J
authors.lastname: Chen
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics*; D000368:Aged; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6; D015179:Colorectal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D006801:Humans; D008297:Male; D008875:Middle Aged; D027701:Organic Cation Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000099254:Organic Cation Transporter 3
chemical_list: D027701:Organic Cation Transport Proteins; D000099254:Organic Cation Transporter 3
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