title: Interaction between ganglioside G(M1) and diosgenin in langmuir monolayers at the air/water interface.
abstract: The interaction between ganglioside GM1 (GM1) and diosgenin (Dios) in mixed monolayers was investigated using surface pressure measurements and atomic force microscopy (AFM). The miscibility and stability of the mixed monolayer was evaluated both in a qualitative and quantitative way in terms of the excess mean molecular area (ΔAex), excess Gibbs energy (ΔGex). The ΔAex of mixed GM1/Dios monolayer was found to have positive deviations from ideality at low Dios mole fractions (XDios = 0.2). Above XDios = 0.2, there was a marked negative deviation from ideal mixing, indicating attractive interaction between G(M1) and Dios. According to the values of excess Gibbs energy of mixing monolayers, the more stable monolayers assayed was: XDios = 0.6. The compressibility coefficient was assessed at various surface pressures. The monolayer of Dios was more elasticity or rigid than G(M1). The AFM images for the mixed monolayers at 30 mN/m indicated there was obvious phase separation in the mixed monolayers. These findings will provide useful information for understanding the interaction between drug and lipids.
authors.affiliation: College of Physics and Information Technology, Shaanxi Normal University, Xi'an, People's Republic of China.
authors.forename: Changchun
authors.initials: C
authors.lastname: Hao
authors.affiliation: College of Physics and Information Technology, Shaanxi Normal University, Xi'an, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Physics and Information Technology, Shaanxi Normal University, Xi'an, People's Republic of China.
authors.forename: Runguang
authors.initials: R
authors.lastname: Sun
authors.affiliation: College of Physics and Information Technology, Shaanxi Normal University, Xi'an, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: College of Physics and Information Technology, Shaanxi Normal University, Xi'an, People's Republic of China.
authors.forename: Guangxiao
authors.initials: G
authors.lastname: He
mesh_terms: D000388:Air; D055598:Chemical Phenomena; D004144:Diosgenin / Q000378:metabolism*; D005677:G(M1) Ganglioside / Q000378:metabolism*; D018625:Microscopy, Atomic Force; D013499:Surface Properties; D014867:Water
chemical_list: D014867:Water; D005677:G(M1) Ganglioside; D004144:Diosgenin
keywords: atomic force microscopy; ganglioside GM1; miscibility; molecular interaction; monolayer