title: Spectral imaging in preclinical research and clinical pathology.
abstract: Spectral imaging methods are attracting increased interest from researchers and practitioners in basic science, preclinical and clinical arenas. A combination of better labeling reagents and better optics creates opportunities to detect and measure multiple parameters at the molecular and cellular level. These tools can provide valuable insights into the basic mechanisms of life, and yield diagnostic and prognostic information for clinical applications. There are many multispectral technologies available, each with its own advantages and limitations. This chapter will present an overview of the rationale for spectral imaging, and discuss the hardware, software and sample labeling strategies that can optimize its usefulness in clinical settings.
authors.affiliation: Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Levenson
authors.forename: Joseph
authors.initials: J
authors.lastname: Beechem
authors.forename: George
authors.initials: G
authors.lastname: McNamara
mesh_terms: D000818:Animals; D058948:Cell Tracking / Q000295:instrumentation*; D003581:Cytodiagnosis / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D057054:Molecular Imaging / Q000295:instrumentation*; D012107:Research Design; D013057:Spectrum Analysis / Q000295:instrumentation*