title: Inflammation and incretins.
abstract: Nutrient excess results in systemic inflammation in diabetes contributing to insulin resistance, dyslipidaemia and increased cardiovascular risk. GLP-1 agonists and DPP-4 inhibitors, which are now well accepted therapies for diabetes may play a unique role in modulating this inflammatory process. Incretin based therapies have shown beneficial anti-inflammatory effects on surrogate markers but cardiovascular outcome data is still lacking.
authors.affiliation: TDH Labs, Varanasi, Uttar Pradesh, India .
authors.forename: Amitabh
authors.initials: A
authors.lastname: Hatwal
keywords: DPP-4 inhibitor; GLP-1 agonist; Inflammation; diabetes
references.citation: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9583-8
references.pmid: 15983379
references.citation: Atherosclerosis. 2012 Apr;221(2):375-82
references.pmid: 22284365
references.citation: Cell Metab. 2006 Mar;3(3):153-65
references.pmid: 16517403
references.citation: Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1285-90
references.pmid: 19164583
references.citation: Diabetologia. 2012 Sep;55(9):2456-68
references.pmid: 22722451
references.citation: Diabetologia. 2011 Nov;54(11):2741-4
references.pmid: 21892687
references.citation: J Clin Endocrinol Metab. 2010 Jun;95(6):2607-9
references.pmid: 20525907
references.citation: Endocr Rev. 2012 Apr;33(2):187-215
references.pmid: 22323472
references.citation: J Clin Endocrinol Metab. 2012 Jan;97(1):198-207
references.pmid: 22013105
references.citation: J Clin Invest. 2005 May;115(5):1111-9
references.pmid: 15864338
references.citation: Circulation. 2011 Nov 22;124(21):2338-49
references.pmid: 22007077
references.citation: Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G762-72
references.pmid: 22268099
references.citation: Diabetologia. 2010 Jan;53(1):1-6
references.pmid: 19894028
references.citation: Diabetologia. 2010 Apr;53(4):730-40
references.pmid: 20225396
references.citation: J Clin Endocrinol Metab. 2012 Sep;97(9):3333-41
references.pmid: 22745245