title: Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models.
abstract: BACKGROUND
  Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Currently, there is an urgent need for developing novel therapeutic agents for treating OM based on full understanding of molecular pathogenesis in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM.
  
  
  OBJECTIVE
  To provide a state-of-the-art review concerning recent advances in OM in the areas of molecular biology, biochemistry, genetics, and animal model studies and to discuss the future directions of OM studies in these areas.
  
  
  METHODS
  A structured search of the current literature (since June 2007). The authors searched PubMed for published literature in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM.
  
  
  RESULTS
  Over the past 4 years, significant progress has been made in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. These studies brought new insights into our understanding of the molecular and biochemical mechanisms underlying the molecular pathogenesis of OM and helped identify novel therapeutic targets for OM.
  
  
  CONCLUSIONS
  Our understanding of the molecular pathogenesis of OM has been significantly advanced, particularly in the areas of inflammation, innate immunity, mucus overproduction, mucosal hyperplasia, middle ear and inner ear interaction, genetics, genome sequencing, and animal model studies. Although these studies are still in their experimental stages, they help identify new potential therapeutic targets. Future preclinical and clinical studies will help to translate these exciting experimental research findings into clinical applications.
authors.affiliation: Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA. jdli@gsu.edu
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Li
authors.forename: Ann
authors.initials: A
authors.lastname: Hermansson
authors.forename: Allen F
authors.initials: AF
authors.lastname: Ryan
authors.forename: Lauren O
authors.initials: LO
authors.lastname: Bakaletz
authors.forename: Steve D
authors.initials: SD
authors.lastname: Brown
authors.forename: Michael T
authors.initials: MT
authors.lastname: Cheeseman
authors.forename: Steven K
authors.initials: SK
authors.lastname: Juhn
authors.forename: Timothy T K
authors.initials: TT
authors.lastname: Jung
authors.forename: David J
authors.initials: DJ
authors.lastname: Lim
authors.forename: Jae Hyang
authors.initials: JH
authors.lastname: Lim
authors.forename: Jizhen
authors.initials: J
authors.lastname: Lin
authors.forename: Sung-Kyun
authors.initials: SK
authors.lastname: Moon
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Post
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D018925:Chemokines / Q000097:blood; D002648:Child; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D007758:Ear, Inner / Q000276:immunology; D004432:Ear, Middle / Q000276:immunology; D019317:Evidence-Based Medicine; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006314:Hearing Loss, Conductive / Q000209:etiology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D010033:Otitis Media / Q000097:blood / Q000150:complications / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000628:therapy
chemical_list: D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines
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