title: Effects of a chicken collagen hydrolysate on the circulation system in subjects with mild hypertension or high-normal blood pressure.
abstract: We investigated the effects of a chicken collagen hydrolysate (CCH) on the circulation system in humans. A total of 58 subjects with either mild hypertension (systolic blood pressure (SBP) of 140-159 mmHg or diastolic blood pressure (DBP) 90-99 mmHg) or high-normal blood pressure (SBP 130-139 mmHg or DBP 85-89 mmHg) were assigned to two groups, one involving a placebo and the other, the test food (including CCH of 2.9 g/d). The parameters related to each subject's circulation system were monitored over the study period of 18 weeks. The Δbrachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness and marker of vascular damage, was significantly lower in the test food group than in the placebo group during the treatment period. The blood pressure in the test food group was also significantly lower than that in the placebo group, while the serum nitrogen oxide was higher in the test food group after the treatment. These results suggest that CCH exerted modulatory effects on the human circulation system.
authors.affiliation: Research and Development Center, Nippon Meat Packers, Inc., Ibaraki, Japan. t.kouguchi@nipponham.co.jp
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kouguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohmori
authors.forename: Muneshige
authors.initials: M
authors.lastname: Shimizu
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takahata
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Maeyama
authors.forename: Takuya
authors.initials: T
authors.lastname: Suzuki
authors.forename: Fumiki
authors.initials: F
authors.lastname: Morimatsu
authors.forename: Soichi
authors.initials: S
authors.lastname: Tanabe
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D001775:Blood Circulation; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D002319:Cardiovascular System / Q000503:physiopathology*; D002645:Chickens; D003094:Collagen / Q000378:metabolism*; D005260:Female; D006339:Heart Rate; D006801:Humans; D006868:Hydrolysis; D006973:Hypertension / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology* / Q000652:urine; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D016482:Urinalysis
chemical_list: D003094:Collagen