title: Is galectin-3 antibody a useful marker in the diagnosis of malignant pleural mesothelioma?
abstract: Malignant pleural mesothelioma (MPM) is a challenging diagnosis characterized by the absence of real specific diagnostic markers. Positivity with the galectin-3 antibody was assessed by a cytoplasmic expression in 17 MPM. Fourteen cases expressed the galectin-3 antibody. The three negative cases consisted of epithelioid, biphasic, and sarcomatoid MPM. The 14 positive cases consisted of epithelioid MPM in 12 cases, sarcomatoid MPM in one case, and biphasic MPM in one case. In spite of our inability to prove the real diagnostic value of the galectin-3 antibody, our findings make us wonder about the implication of this antibody in the carcinogenesis of MPM.
authors.affiliation: Department of Pathology, Abderrahman Mami Hospital, Ariana, Tunis, Tunisia. mlika.zorgati.mona@hotmail.com
authors.forename: Mona
authors.initials: M
authors.lastname: Mlika
authors.forename: Aida
authors.initials: A
authors.lastname: Ayadi-Kaddour
authors.forename: Meriem
authors.initials: M
authors.lastname: Ksantini
authors.forename: Saadia
authors.initials: S
authors.lastname: Bouraoui
authors.forename: Sabah
authors.initials: S
authors.lastname: Mzabi
authors.forename: Faouzi
authors.initials: F
authors.lastname: El Mezni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D037502:Galectin 3 / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D010994:Pleura / Q000378:metabolism / Q000473:pathology; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D037502:Galectin 3