title: Hepatitis B virus subgenotyping: history, effects of recombination, misclassifications, and corrections.
abstract: Hepatitis B virus (HBV) has evolved into phylogenetically separable genotypes and subgenotypes. Accurately assigning the subgenotype for an HBV strain is of clinical and epidemiological significance. In this paper, we review the recommendations currently employed for HBV subgenotyping, the history of HBV subgenotyping, the effects of recombination on HBV subgenotyping, misclassifications in HBV subgenotyping, and suggestions are made to correct the misclassifications. Finally, proposals are made to guide future HBV subgenotyping.
authors.affiliation: School of Basic Medical Sciences, Taishan Medical College, Taian 271000, Shandong, China. wfshi.tsmc@gmail.com
authors.forename: Weifeng
authors.initials: W
authors.lastname: Shi
authors.forename: Zhong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Cheng
authors.initials: C
authors.lastname: Ling
authors.forename: Weimin
authors.initials: W
authors.lastname: Zheng
authors.forename: Chaodong
authors.initials: C
authors.lastname: Zhu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Carr
authors.forename: Desmond G
authors.initials: DG
authors.lastname: Higgins
mesh_terms: D060005:Genotyping Techniques; D006509:Hepatitis B / Q000175:diagnosis / Q000821:virology; D006515:Hepatitis B virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D011995:Recombination, Genetic