title: Polycyclic aromatic hydrocarbons in lung tissue of patients with pulmonary cancer from Romania. Influence according as demographic status and ABO phenotypes.
abstract: The lung is a target organ for the toxic effects of several chemical agents, including natural products, industrial chemicals, environmental agents, and occasionally, drugs. The assessment of PAHs in the lungs of patients with pulmonary cancer is important because these pollutants have mutagenic, carcinogenic and endocrine-disrupting properties. This study included 31 histological confirmed lung cancer cases diagnosed consecutively at the Clinical Hospital of Pneumology (Iasi, Romania) from 2008 to 2009. Analyses were carried out using an accelerated solvent extraction technique and HPLC with a fluorescence detector. Fifteen PAHs were detected in all analyzed samples with non-carcinogenic compounds significantly elevated (45.57 ng g(-1) wet tissue) against carcinogenic compounds (6.12 ng g(-1) wet tissue). The mean ± SD lung tissue level of benzo(a)anthracene (3.57 ± 4.64 ng g(-1) wet tissue), a carcinogenic PAH, was found to be significantly higher (p<0.05) in patients from urban areas compared with the level (1.22 ± 1.45 ng g(-1) wet tissue) in patients from rural areas. Similarly, the levels of non-carcinogenic acenaphtene (8.95 ± 13.32 ng g(-1) wet tissue), fluoranthrene (5.31 ± 5.40 ng g(-1) wet tissue) and anthracene (4.83 ± 7.57 ng g(-1) wet tissue) were also detected to be higher (p<0.05) in the urban group compared to the levels for the rural group (1.46 ± 2.34, 1.83 ± 2.50 and 1.89 ± 3.79 ng g(-1) wet tissue, respectively). High concentrations of PAHs, especially carcinogenic PAHs, such as benzo(a)pyrene, benzo(a)anthracene, benzo(b)fluoranthrene, and benzo(k)fluoranthrene, were observed in lung tissue samples collected from subjects with A and O blood types.
authors.affiliation: Department for Quality of Drugs, "Gr.T.Popa" University of Medicine and Pharmacy Iasi, Str., Universitatii 16, 700115 Iasi, Romania. bogdan.cioroiu@gmail.com
authors.forename: Bogdan Ionel
authors.initials: BI
authors.lastname: Cioroiu
authors.forename: Doina
authors.initials: D
authors.lastname: Tarcau
authors.forename: Simona
authors.initials: S
authors.lastname: Cucu-Man
authors.forename: Irina
authors.initials: I
authors.lastname: Chisalita
authors.forename: Mona
authors.initials: M
authors.lastname: Cioroiu
mesh_terms: D000017:ABO Blood-Group System / Q000032:analysis; D000368:Aged; D002274:Carcinogens, Environmental / Q000032:analysis*; D004785:Environmental Pollutants / Q000032:analysis*; D005260:Female; D006801:Humans; D008168:Lung / Q000737:chemistry / Q000473:pathology*; D008175:Lung Neoplasms / Q000097:blood* / Q000737:chemistry / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis*; D012383:Romania / Q000453:epidemiology
chemical_list: D000017:ABO Blood-Group System; D002274:Carcinogens, Environmental; D004785:Environmental Pollutants; D011084:Polycyclic Aromatic Hydrocarbons