title: Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy.
abstract: The synthesis and characterization of a highly photostable bromo-substituted BODIPY dye (I) fused-ring-expanded with thienopyrrole moieties is reported. The results of MTT assays and flow cytometric analyses in living HeLa cells demonstrate that I has a high singlet oxygen quantum yield (ΦΔ = 0.63) and exhibits photocytotoxicity upon irradiation in the NIR region making it potentially suitable for use in PDT.
authors.affiliation: State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing 210093, PR China.
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Yang
authors.forename: Qiuli
authors.initials: Q
authors.lastname: Guo
authors.forename: Huachao
authors.initials: H
authors.lastname: Chen
authors.forename: Zhikuan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Zijian
authors.initials: Z
authors.lastname: Guo
authors.forename: Zhen
authors.initials: Z
authors.lastname: Shen
mesh_terms: D001896:Boron Compounds / Q000737:chemistry / Q000627:therapeutic use*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D011758:Pyrroles / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D017319:Photosensitizing Agents; D011758:Pyrroles; C521801:thienopyrrole