title: Synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line.
abstract: BACKGROUND
  Preparation of some novel heterocyclic compounds with long alkyl and alkenyl chain of cytotoxic activity.
  
  
  METHODS
  Gamma linolenic acid, a poly unsaturated fatty acid and stearic acid, a saturated fatty acid were isolated from the microalga Spirulina platensis. Some novel gamma linolenic acid and stearic acid analogues having 1,3,4-oxadiazole and 1,2,4-triazole were synthesized and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. Cytotoxicity of these compounds was evaluated by the growth inhibition of A-549 cells in-vitro.
  
  
  RESULTS
  Compound 1 and 3 showed comparable cytotoxicity against the human lung carcinoma A-549 cell lines.
authors.affiliation: Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Udhagamandalam, Rock lands, Ooty 643 001, Tamilnadu, India. jubiejawahar@gmail.com
authors.forename: Selvaraj
authors.initials: S
authors.lastname: Jubie
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Dhanabal
authors.forename: Mohammed
authors.initials: M
authors.lastname: Afzal Azam
authors.forename: Nithyanantham
authors.initials: N
authors.lastname: Muruganantham
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Kalirajan
authors.forename: Kannan
authors.initials: K
authors.lastname: Elango
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010069:Oxadiazoles / Q000737:chemistry; D053545:Spirulina / Q000737:chemistry*; D013229:Stearic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D014230:Triazoles / Q000737:chemistry; D017965:gamma-Linolenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D003603:Cytotoxins; D010069:Oxadiazoles; D013229:Stearic Acids; D014230:Triazoles; C045575:1,2,4-triazole; D017965:gamma-Linolenic Acid
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