title: The miR-146a rs2910164 G > C polymorphism and susceptibility to digestive cancer in Chinese.
abstract: BACKGROUND
  Several studies have reported the role of the miR-146a rs2910164 G > C polymorphism as a susceptibility factor for several digestive cancers. However, the results have been controversial. Therefore, we conducted the present meta-analysis to obtain the most reliable estimate of the association.
  
  
  METHODS
  PubMed, Embase and Web of Science databases were searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between miR-146a rs2910164 G > C polymorphism and digestive cancer risk. A total of four eligible studies including 3,447 cases and 5,041 controls based on the search criteria were included.
  
  
  RESULTS
  We observed that miR-146a rs2910164 G > C polymorphism was not significantly correlated with digestive cancer risks when all studies were pooled into the meta-analysis. While we found that miR-146a rs2910164 polymorphism was not associated with gastric cancer, it was significantly linked with hepatocellular cancer risk (the homozygote codominant model: OR = 1.40, 95% CI = 1.04-1.87). In the stratified analysis by ethnicity, significant associations were observed in Chinese population for the allele contrast model (OR = 1.25; 95% CI = 1.12-1.38), for the homozygote codominant model (OR = 1.62; 95% CI = 1.28-2.04), and for the recessive model (OR = 1.38; 95% CI = 1.16-1.64). However, studies with Asian groups presented no significant association for all genetic models.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the miR-146a rs2910164 G > C polymorphism is a low-penetrant risk factor for digestive cancers in Chinese.
authors.affiliation: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wu
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Wei-Qi
authors.initials: WQ
authors.lastname: Dai
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Chuan-Yong
authors.initials: CY
authors.lastname: Guo
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D016001:Confidence Intervals; D004067:Digestive System Neoplasms / Q000208:ethnology / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs