title: Corpus callosum integrity and neuropsychological performance after traumatic brain injury: a diffusion tensor imaging study.
abstract: OBJECTIVE
  (1) Detailed analysis of diffusion tensor imaging (DTI) parameters (fractional anisotropy and radial diffusivity) to evaluate white matter integrity in the corpus callosum (CC), and (2) examine correlations between DTI data and performance on multiple measures of cognitive functioning.
  
  
  METHODS
  Twelve individuals with a history of complicated mild, moderate, or severe traumatic brain injury (TBI) who were an average of 1.7 years postinjury and 12 control participants.
  
  
  METHODS
  Standardized and experimental neuropsychological tests; detailed analysis of DTI parameters.
  
  
  RESULTS
  The TBI group demonstrated DTI values suggesting decreased white matter integrity and correlations with severity of injury. Both groups showed correlations between DTI parameters and cognitive measures, with more significant correlations observed for the TBI group. White matter changes in the CC were evident chronically and were related to severity of injury.
  
  
  CONCLUSIONS
  Diffusion tensor imaging parameters suggesting disruptions in white matter in the CC may be implicated in impaired performance, both in terms of cognitive tasks and reaction time, after TBI.
authors.affiliation: School of Medicine, Department of Physical Medicine and Rehabilitation (Drs Arenth, Russell, Scanlon, and Ricker and Ms Kessler); Center for the Neural Basis of Cognition (Drs Arenth, Russell, and Ricker); School of Medicine, Safar Center for Resuscitation Research (Dr Russell), University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Arenth
authors.forename: Kathryn C
authors.initials: KC
authors.lastname: Russell
authors.forename: Joelle M
authors.initials: JM
authors.lastname: Scanlon
authors.forename: Lauren J
authors.initials: LJ
authors.lastname: Kessler
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Ricker
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000175:diagnosis* / Q000534:rehabilitation*; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000503:physiopathology*; D003337:Corpus Callosum / Q000293:injuries / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D009483:Neuropsychological Tests; D011379:Prognosis; D012016:Reference Values; D012680:Sensitivity and Specificity; D055815:Young Adult
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