title: Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment.
abstract: Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy for AD 2 years after baseline was assessed by receiver operating characteristics analyses with area under the curve as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were investigated. Subjects with MCI were selected from the Development of Screening Guidelines and Clinical Criteria for Predementia AD (DESCRIPA) multicenter study (n = 156) and the single-center VU medical center (n = 172). At follow-up, area under the curve was highest for automated atlas-based hippocampal measurement (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) and lateral ventricle (0.60). Slope analysis yielded similar results. Hippocampal measurements correlated with CSF total tau and phosphorylated tau, not with beta-amyloid 1-42. MTA-score and lateral ventricle volume correlated with CSF beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are the best predictors of AD conversion in subjects with MCI.
authors.affiliation: Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, the Netherlands. L.Clerx@maastrichtuniversity.nl
authors.forename: Lies
authors.initials: L
authors.lastname: Clerx
authors.forename: Ineke A
authors.initials: IA
authors.lastname: van Rossum
authors.forename: Leah
authors.initials: L
authors.lastname: Burns
authors.forename: Dirk L
authors.initials: DL
authors.lastname: Knol
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.forename: Frans
authors.initials: F
authors.lastname: Verhey
authors.forename: Pauline
authors.initials: P
authors.lastname: Aalten
authors.forename: Pablo
authors.initials: P
authors.lastname: Lapuerta
authors.forename: Laura
authors.initials: L
authors.lastname: van de Pol
authors.forename: Ronald
authors.initials: R
authors.lastname: van Schijndel
authors.forename: Remko
authors.initials: R
authors.lastname: de Jong
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
authors.forename: Robin
authors.initials: R
authors.lastname: Wolz
authors.forename: Daniel
authors.initials: D
authors.lastname: Rueckert
authors.forename: Martina
authors.initials: M
authors.lastname: Bocchetta
authors.forename: Magdalini
authors.initials: M
authors.lastname: Tsolaki
authors.forename: Flavio
authors.initials: F
authors.lastname: Nobili
authors.forename: Lars-Olaf
authors.initials: LO
authors.lastname: Wahlund
authors.forename: Lennart
authors.initials: L
authors.lastname: Minthon
authors.forename: Lutz
authors.initials: L
authors.lastname: Frölich
authors.forename: Harald
authors.initials: H
authors.lastname: Hampel
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
authors.forename: Pieter Jelle
authors.initials: PJ
authors.lastname: Visser
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology* / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D001284:Atrophy; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003071:Cognition; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis* / Q000473:pathology* / Q000523:psychology; D018450:Disease Progression; D005260:Female; D005544:Forecasting; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins