title: Paeoniflorin, a monoterpene glycoside, attenuates lipopolysaccharide-induced neuronal injury and brain microglial inflammatory response.
abstract: Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Paeoniflorin (PF), a water-soluble monoterpene glycoside found in the root of Paeonia lactiflora Pall, has a wide range of pharmacological functions, such as anti-oxidant, anti-inflammatory, and anti-cancer effects. Neuroprotective potential of PF has also been demonstrated in animal models of neuropathologies. Here, we have examined the efficacy of PF in the repression of inflammation-induced neurotoxicity and microglial inflammatory response. In organotypic hippocampal slice cultures, PF significantly blocked lipopolysaccharide (LPS)-induced hippocampal cell death and productions of nitric oxide (NO) and interleukin (IL)-1β. PF also inhibited the LPS-stimulated productions of NO, tumor necrosis factor-α, and IL-1β from primary microglial cells. These results suggest that PF possesses neuroprotective activity by reducing the production of proinflammatory factors from activated microglial cells.
authors.affiliation: Graduate School of East-West Medical Science, Kyung Hee University, 1 Seochun, Yongin-si, 446-701, Republic of Korea.
authors.forename: Kyong-Nyon
authors.initials: KN
authors.lastname: Nam
authors.forename: Che Gyem
authors.initials: CG
authors.lastname: Yae
authors.forename: Joung-Woo
authors.initials: JW
authors.lastname: Hong
authors.forename: Dong-Hyung
authors.initials: DH
authors.lastname: Cho
authors.forename: Joon H
authors.initials: JH
authors.lastname: Lee
authors.forename: Eunjoo H
authors.initials: EH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D001565:Benzoates / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D001952:Bridged-Ring Compounds / Q000378:metabolism*; D016923:Cell Death / Q000187:drug effects; D005960:Glucosides / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D007155:Immunologic Factors / Q000378:metabolism*; D007249:Inflammation / Q000473:pathology; D053583:Interleukin-1beta / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology / Q000633:toxicity*; D017628:Microglia / Q000187:drug effects* / Q000276:immunology; D039821:Monoterpenes; D018696:Neuroprotective Agents / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D006027:Glycosides
chemical_list: D000893:Anti-Inflammatory Agents; D001565:Benzoates; D001952:Bridged-Ring Compounds; D005960:Glucosides; D007155:Immunologic Factors; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D039821:Monoterpenes; D018696:Neuroprotective Agents; D009569:Nitric Oxide; D014409:Tumor Necrosis Factor-alpha; C015423:peoniflorin; D006027:Glycosides