title: Effects of immediate and delayed loading on peri-implant trabecular structures: a cone beam CT evaluation.
abstract: OBJECTIVE
  To develop a method for characterizing trabecular bone microarchitecture using cone beam computed tomography (CBCT) and to evaluate trabecular bone changes after rehabilitation using immediate versus delayed implant protocols.
  
  
  METHODS
  Six mongrel dogs randomly received 27 titanium implants in the maxillary incisor or mandibular premolar areas, following one of four protocols: (1) normal extraction socket healing; (2) immediate implant placement and immediate loading; (3) delayed implant placement and delayed loading; (4) delayed implant placement and immediate loading. The animals were euthanized at 8 weeks, and block biopsies were scanned using high resolution CBCT. Standard bone structural variables were assessed in coronal, middle, and apical levels.
  
  
  RESULTS
  Coronal and middle regions had more compact, more platelike, and thicker trabeculae. Protocols (2), (3), and (4) had significantly higher values (p < 0.001) than protocol (1) for bone surface density, bone surface volume ratio, and connectivity density, while significantly lower values (p < 0.001) were found for trabecular separation and fractal dimension. However, protocols (2), (3), and (4) did not show significantly different bone remodeling.
  
  
  CONCLUSIONS
  Compared with normal extraction healing, the implant protocols have an improved bone structural integration. Results do not suggest a different bone remodeling pattern when a delayed versus an immediate implant protocol is used.
authors.affiliation: Oral Imaging Center, Department of Oral Health Science, KU Leuven, Leuven, Belgium; Oral Implant Center, West China College of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Jeroen
authors.initials: J
authors.lastname: Van Dessel
authors.forename: Xin
authors.initials: X
authors.lastname: Liang
authors.forename: Maarten
authors.initials: M
authors.lastname: Depypere
authors.forename: Weijian
authors.initials: W
authors.lastname: Zhong
authors.forename: Guowu
authors.initials: G
authors.lastname: Ma
authors.forename: Ivo
authors.initials: I
authors.lastname: Lambrichts
authors.forename: Frederik
authors.initials: F
authors.lastname: Maes
authors.forename: Reinhilde
authors.initials: R
authors.lastname: Jacobs
mesh_terms: D000818:Animals; D001641:Bicuspid / Q000601:surgery; D001706:Biopsy / Q000379:methods; D015519:Bone Density / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D003724:Dental Arch / Q000000981:diagnostic imaging / Q000601:surgery; D003758:Dental Implantation, Endosseous / Q000379:methods*; D004285:Dogs; D017709:Fractals; D021621:Imaging, Three-Dimensional / Q000379:methods; D057893:Immediate Dental Implant Loading / Q000379:methods*; D007180:Incisor / Q000601:surgery; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000601:surgery; D008437:Maxilla / Q000000981:diagnostic imaging / Q000601:surgery; D011897:Random Allocation; D014081:Tooth Extraction / Q000379:methods; D020390:Tooth Socket / Q000000981:diagnostic imaging* / Q000601:surgery; D014945:Wound Healing / Q000502:physiology
keywords: animal experiments; cone beam CT; dental implants; immediate loading; trabecular bone