title: Rice protein ameliorates the progression of diabetic nephropathy in Goto-Kakizaki rats with high-sucrose feeding.
abstract: The effect of rice protein (RP) on diabetic nephropathy in non-obese, spontaneous type 2 diabetic Goto-Kakizaki (GK) rats was investigated.GK rats at 7 weeks of age were fed 20% RP or casein (C) in standard or high-sucrose diets for 10 weeks. Plasma total cholesterol,TAG, alkaline phosphatase (ALP), adiponectin, creatinine and urinary albumin excretion (UAE) were measured and renal histology was evaluated. Compared with C, RP lowered plasma TAG and improved plasma adiponectin levels in GK rats fed the standard diet (P<0·05), and also lowered total cholesterol and ALP in high-sucrose-fed GK rats (P<0·05). RP markedly suppressed the sharp increase in UAE when GK rats were fed high-sucrose diets (P<0·05), and prevented glomerular mesangial matrix expansion in the deep renal cortex near the corticomedullary junction (P<0·05). These results strongly indicate that dietary RP can ameliorate the progression of diabetic nephropathy at an early stage compared with C.
authors.affiliation: Center for Transdisciplinary Research, Niigata University, Niigata 950-2181, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kubota
authors.forename: Reiko
authors.initials: R
authors.lastname: Watanabe
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kabasawa
authors.forename: Noriaki
authors.initials: N
authors.lastname: Iino
authors.forename: Akihiko
authors.initials: A
authors.lastname: Saito
authors.forename: Takehisa
authors.initials: T
authors.lastname: Kumagai
authors.forename: Shinobu
authors.initials: S
authors.lastname: Fujimura
authors.forename: Motoni
authors.initials: M
authors.lastname: Kadowaki
mesh_terms: D052242:Adiponectin / Q000097:blood; D000419:Albuminuria / Q000209:etiology; D000818:Animals; D002364:Caseins / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism / Q000473:pathology; D003928:Diabetic Nephropathies / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism; D004044:Dietary Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D019422:Dietary Sucrose / Q000009:adverse effects*; D018450:Disease Progression; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D012275:Oryza / Q000737:chemistry*; D010940:Plant Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D002364:Caseins; D004044:Dietary Proteins; D019422:Dietary Sucrose; D010940:Plant Proteins; D014280:Triglycerides; D002784:Cholesterol