title: The iScore predicts functional outcome in Korean patients with ischemic stroke.
abstract: OBJECTIVE
  Several stroke risk scores for prediction of functional outcome have been developed, but rarely validated in Asian populations. We assessed the validity of the iScore, recently developed from Canadian stroke population, in an Asian stroke population from Korea.
  
  
  METHODS
  We applied the iScore to 4061 eligible participants with acute ischemic stroke in the nationwide multicenter stroke registry in Korea. The main outcome was poor functional outcome defined as having a modified Rankin Scale 3 to 6 at 3 months after stroke onset. The secondary outcome was death at 3 months. C-statistics were calculated to assess performance of the iScore.
  
  
  RESULTS
  Poor functional outcome was found in 1496 patients (36.8%), whereas death at 3 months occurred in 294 patients (7.2%). C-statistics were 0.819 (95% confidence interval, 0.805-0.833) for poor functional outcome and 0.861 (95% confidence interval, 0.840-0.883) for death. Overall, there was a high correlation between observed and expected outcomes for poor functional outcome (Pearson correlation coefficient, r=0.990) and for death (r=0.969) according to risk score.
  
  
  CONCLUSIONS
  The iScore reliably predicts poor functional outcome or death at 3 months after stroke in Korean patients.
authors.affiliation: Department of Neurology, Seoul Medical Center, 316 Sinnae-dong, Jungnang-gu, Seoul, Korea 131-130. strokezero@gmail.com
authors.forename: Tai Hwan
authors.initials: TH
authors.lastname: Park
authors.forename: Gustavo
authors.initials: G
authors.lastname: Saposnik
authors.forename: Hee-Joon
authors.initials: HJ
authors.lastname: Bae
authors.forename: Soo Joo
authors.initials: SJ
authors.lastname: Lee
authors.forename: Kyung Bok
authors.initials: KB
authors.lastname: Lee
authors.forename: Jun
authors.initials: J
authors.lastname: Lee
authors.forename: Jong-Moo
authors.initials: JM
authors.lastname: Park
authors.forename: Jay Chol
authors.initials: JC
authors.lastname: Choi
authors.forename: Dong-Eog
authors.initials: DE
authors.lastname: Kim
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Cho
authors.forename: Joon-Tae
authors.initials: JT
authors.lastname: Kim
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Cha
authors.forename: Juneyoung
authors.initials: J
authors.lastname: Lee
authors.forename: Kyung-Ho
authors.initials: KH
authors.lastname: Yu
authors.forename: Byung-Chul
authors.initials: BC
authors.lastname: Lee
authors.forename: Byung-Woo
authors.initials: BW
authors.lastname: Yoon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002545:Brain Ischemia / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012042:Registries; D056910:Republic of Korea; D012306:Risk; D018570:Risk Assessment; D020521:Stroke / Q000175:diagnosis* / Q000503:physiopathology; D016896:Treatment Outcome