title: [Influence of postoperative oral steroid treatment on retinal sensitivity in patients after macular surgery. A randomized, controlled, clinical trial].
abstract: BACKGROUND
  The aim of this study was to evaluate the effect of postoperative systemic steroid treatment on retinal sensitivity in patients with epiretinal membrane (ERM) after successful surgery.
  
  
  METHODS
  A total of 28 patients with ERM, macular edema and visual loss were included in this study. All patients were treated with combined 23 gauge vitrectomy and peeling of the ERM and inner limiting membrane (ILM). After randomization the first group (n = 14) was treated with postoperative systemic steroids (100 mg prednisolone per day for 5 days) and the second group (n = 14) served as a control group. Follow-up examinations were performed up to 12 months.
  
  
  RESULTS
  After 12 months a statistically significant increase in visual acuity with a gain of 17/10 letters in the steroid/control group as well as significant decrease of the central retinal thickness of 107/128 µm could be observed (p < 0.05). In the steroid/control group mean retinal sensitivity increased from 14.0/14.3 dB after 12 months in comparison to 11.7/11.9 dB at baseline examination (p < 0.05).
  
  
  CONCLUSIONS
  Postoperative oral steroid treatment does not seem to be beneficial in patients with macular pucker surgery.
authors.affiliation: Universitätsklinik für Augenheilkunde und Optometrie, Medizinische Universität Wien, Waehringer Guertel 18-20, 1090, Wien, Österreich.
authors.forename: S
authors.initials: S
authors.lastname: Rezar
authors.forename: S
authors.initials: S
authors.lastname: Sacu
authors.forename: M
authors.initials: M
authors.lastname: Ritter
authors.forename: W
authors.initials: W
authors.lastname: Bühl
authors.forename: M
authors.initials: M
authors.lastname: Georgopoulos
authors.forename: U
authors.initials: U
authors.lastname: Schmidt-Erfurth
authors.forename: C
authors.initials: C
authors.lastname: Prünte
mesh_terms: D000284:Administration, Oral; D000368:Aged; D003131:Combined Modality Therapy / Q000379:methods; D019773:Epiretinal Membrane / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D008297:Male; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D011182:Postoperative Care / Q000379:methods; D013256:Steroids / Q000008:administration & dosage*; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D013256:Steroids
references.citation: Klin Monbl Augenheilkd. 2003 Jun;220(6):384-90
references.pmid: 12830391
references.citation: Ophthalmology. 1986 May;93(5):602-10
references.pmid: 3725320
references.citation: Am J Ophthalmol. 2012 Jan;153(1):103-10.e1
references.pmid: 21937015
references.citation: Ophthalmology. 1986 Jul;93(7):978-83
references.pmid: 3763143
references.citation: Retina. 2011 May;31(5):915-23
references.pmid: 21487341
references.citation: Retina. 2012 May;32(5):892-6
references.pmid: 22252232
references.citation: Retina. 2010 Sep;30(8):1254-61
references.pmid: 20827142
references.citation: Ophthalmology. 1997 Jun;104(6):1033-40
references.pmid: 9186446
references.citation: Ophthalmology. 1994 Aug;101(8):1397-402; discussion 1403
references.pmid: 8058284
references.citation: Am J Ophthalmol. 1988 Nov 15;106(5):533-5
references.pmid: 3189467
references.citation: Br J Ophthalmol. 2000 Sep;84(9):1064-7
references.pmid: 10966969
references.citation: Ophthalmology. 2003 Jan;110(1):34-40
references.pmid: 12511343
references.citation: Eye (Lond). 2011 Feb;25(2):180-4
references.pmid: 21109773
references.citation: Ophthalmology. 1986 Nov;93(11):1413-7
references.pmid: 3808601
references.citation: Am J Ophthalmol. 2005 Aug;140(2):288-94
references.pmid: 16023066
references.citation: Am J Ophthalmol. 2006 Jun;141(6):1112-1119
references.pmid: 16765681
references.citation: Retina. 2005 Oct-Nov;25(7):846-50
references.pmid: 16205562
references.citation: Am J Ophthalmol. 2003 Oct;136(4):737-9
references.pmid: 14516818
references.citation: Eur J Ophthalmol. 2011 Sep-Oct;21(5):631-6
references.pmid: 21500185
references.citation: Ophthalmology. 1991 Jul;98(7):1109-14
references.pmid: 1891221
references.citation: Acta Ophthalmol. 2010 Aug;88(5):558-63
references.pmid: 19432873
references.citation: Arch Ophthalmol. 1967 Aug;78(2):151-65
references.pmid: 4952925
references.citation: Graefes Arch Clin Exp Ophthalmol. 2011 Jan;249(1):3-9
references.pmid: 20658146
references.citation: Retina. 1990;10(4):288-96
references.pmid: 2089546
references.citation: Dev Ophthalmol. 1997;29:61-3
references.pmid: 9413695