title: Feral swine brucellosis in the United States and prospective genomic techniques for disease epidemiology.
abstract: Brucellosis is a common infection of feral swine throughout the United States. With the recent expansion of feral swine populations across the country, this disease poses an increasing threat to agriculture and hunters. The standard approach to Brucella surveillance in feral swine has been serological testing, which gives an indication of past exposure and is a rapid method of determining populations where Brucella is present. More in-depth analyses require bacterial isolation to determine the Brucella species and biovar involved. Ultimately, for a comprehensive understanding of Brucella epizootiology in feral swine, incorporation of genotyping assays has become essential. Fortunately, the past decade has given rise to an array of genetic tools for assessing Brucella transmission and dispersal. This review aims to synthesize what is known about brucellosis in feral swine and will cover prospective genomic techniques that may be utilized to develop more complete understanding of the disease and its transmission history.
authors.affiliation: Center for Microbial Genetics and Genomics, P.O. Box 4073, Northern Arizona University, Flagstaff, AZ 86011-4073, USA.
authors.forename: Owen P
authors.initials: OP
authors.lastname: Leiser
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Corn
authors.forename: Brandon S
authors.initials: BS
authors.lastname: Schmit
authors.forename: Paul S
authors.initials: PS
authors.lastname: Keim
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Foster
mesh_terms: D000818:Animals; D002002:Brucella / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification* / Q000502:physiology; D002006:Brucellosis / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D023281:Genomics; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology* / Q000382:microbiology* / Q000635:transmission; D014481:United States / Q000453:epidemiology
keywords: Brucellosis; Epidemiology; Feral swine; Genomics; Next generation sequencing