title: Dysplastic nevi and melanoma.
abstract: Dysplastic nevi are described as being on a continuum between common acquired nevi and melanoma because they are morphologically and biologically intermediate between these 2 entities. Since initially being reported as histologic lesions observed in melanoma-prone families, there has been considerable debate about the definition of dysplastic nevi, the histologic and clinical criteria used to define them, and their biologic importance. Their role as precursor lesions for melanoma is not their primary role in their relationship to melanoma because of the rarity of transformation of any individual nevus to a melanoma. Although there is still no single, universally agreed upon histologic or clinical definition or even name for these nevi, dysplastic nevi should be considered important because of their association with an increased risk for melanoma.
authors.affiliation: Genetic Epidemiology Branch/NCI, Executive Plaza South, Room 7004, 6120 Executive Blvd. MSC 7236, Bethesda, MD 20892, USA. goldstea@mail.nih.gov
authors.forename: Alisa M
authors.initials: AM
authors.lastname: Goldstein
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Tucker
mesh_terms: D018450:Disease Progression; D004416:Dysplastic Nevus Syndrome / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008545:Melanoma / Q000209:etiology* / Q000473:pathology; D012307:Risk Factors
references.citation: Eur J Hum Genet. 2008 Sep;16(9):1135-41
references.pmid: 18398432
references.citation: Oncogene. 2003 May 19;22(20):3053-62
references.pmid: 12789280
references.citation: J Invest Dermatol. 1993 Mar;100(3):350S-355S
references.pmid: 8440923
references.citation: Hematol Oncol Clin North Am. 2009 Jun;23(3):383-95, vii
references.pmid: 19464592
references.citation: JAMA. 1997 May 14;277(18):1439-44
references.pmid: 9145715
references.citation: Dermatol Clin. 2012 Jul;30(3):389-404
references.pmid: 22800547
references.citation: Hum Genet. 1997 Dec;101(3):359-64
references.pmid: 9439668
references.citation: Arch Dermatol. 2001 Nov;137(11):1493-6
references.pmid: 11708953
references.citation: Eur J Cancer. 2005 Jan;41(1):28-44
references.pmid: 15617989
references.citation: J Invest Dermatol. 2012 Jul;132(7):1763-74
references.pmid: 22475760
references.citation: Arch Dermatol. 2003 Mar;139(3):282-8
references.pmid: 12622618
references.citation: Cancer. 1980 Oct 15;46(8):1787-94
references.pmid: 7427881
references.citation: J Cutan Pathol. 2004 Sep;31(8):523-30
references.pmid: 15268706
references.citation: J Natl Cancer Inst. 1998 May 6;90(9):709-11
references.pmid: 9586669
references.citation: Br J Dermatol. 2008 Sep;159(3):669-76
references.pmid: 18616769
references.citation: J Am Acad Dermatol. 2007 Sep;57(3):428-34
references.pmid: 17624623
references.citation: Histopathology. 1988 Mar;12(3):289-300
references.pmid: 3366444
references.citation: Consens Statement. 1992 Jan 27-29;10(1):1-25
references.pmid: 1515516
references.citation: Lancet. 1977 Apr 16;1(8016):864-5
references.pmid: 67377
references.citation: J Invest Dermatol. 2000 Jan;114(1):28-33
references.pmid: 10620111
references.citation: J Am Acad Dermatol. 2012 Jul;67(1):e17-27
references.pmid: 21683472
references.citation: J Invest Dermatol. 2010 Feb;130(2):520-8
references.pmid: 19710684
references.citation: Nat Genet. 2009 Aug;41(8):915-9
references.pmid: 19578365
references.citation: J Med Genet. 1978 Oct;15(5):352-6
references.pmid: 739524
references.citation: Histopathology. 2010 Jan;56(1):112-20
references.pmid: 20055909
references.citation: Melanoma Res. 2010 Aug;20(4):266-72
references.pmid: 20526219
references.citation: Arch Dermatol. 1997 Aug;133(8):953-8
references.pmid: 9267239
references.citation: J Am Acad Dermatol. 2012 Jul;67(1):1.e1-16; quiz 17-8
references.pmid: 22703915
references.citation: Oncogene. 2003 May 19;22(20):3042-52
references.pmid: 12789279
references.citation: Int J Cancer. 2009 Jan 15;124(2):420-8
references.pmid: 18792098
references.citation: Cancer Epidemiol Biomarkers Prev. 1995 Jan-Feb;4(1):37-40
references.pmid: 7894322
references.citation: Lancet. 1980 Nov 8;2(8202):1024
references.pmid: 6107646
references.citation: JAMA. 1992 Sep 9;268(10):1314-9
references.pmid: 1507379
references.citation: J Natl Cancer Inst. 2004 May 19;96(10):785-95
references.pmid: 15150307
references.citation: Arch Dermatol. 2011 Nov;147(11):1269-75
references.pmid: 21768448
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2384-90
references.pmid: 16214921
references.citation: Mod Pathol. 1989 Jul;2(4):306-19
references.pmid: 2762287
references.citation: Arch Dermatol. 1978 May;114(5):732-8
references.pmid: 646394
references.citation: Eur J Cancer. 1993;29A(6):831-9
references.pmid: 8484972
references.citation: Eur J Hum Genet. 2007 Jan;15(1):94-102
references.pmid: 17063143
references.citation: J Am Acad Dermatol. 1993 Jul;29(1):51-7
references.pmid: 8315078
references.citation: Cancer. 2002 Jun 15;94(12):3192-209
references.pmid: 12115352
references.citation: J Am Acad Dermatol. 1994 May;30(5 Pt 1):707-14
references.pmid: 8176008