title: Obstructive sleep apnea and cardiovascular disease in blacks: a call to action from the Association of Black Cardiologists.
abstract: Obstructive sleep apnea (OSA) has emerged as a new and important risk factor for cardiovascular disease (CVD). Over the last decade, epidemiologic and clinical research has consistently supported the association of OSA with increased cardiovascular (CV) morbidity and mortality. Such evidence prompted the American Heart Association to issue a scientific statement describing the need to recognize OSA as an important target for therapy in reducing CV risk. Emerging facts suggest that marked racial differences exist in the association of OSA with CVD. Although both conditions are more prevalent in blacks, almost all National Institutes of Health-funded research projects evaluating the relationship between OSA and CV risk have been conducted in predominantly white populations. There is an urgent need for research studies investigating the CV impact of OSA among high-risk minorities, especially blacks. This article first examines the evidence supporting the association between OSA and CVD and reviews the influence of ethnic/racial differences on this association. Public health implications of OSA and future directions, especially regarding minority populations, are discussed.
authors.affiliation: Association of Black Cardiologists, Inc, Washington, DC, USA. olafiranyeo@upmc.edu
authors.forename: Oladipupo
authors.initials: O
authors.lastname: Olafiranye
authors.forename: Olakunle
authors.initials: O
authors.lastname: Akinboboye
authors.forename: Judith E
authors.initials: JE
authors.lastname: Mitchell
authors.forename: Gbenga
authors.initials: G
authors.lastname: Ogedegbe
authors.forename: Girardin
authors.initials: G
authors.lastname: Jean-Louis
mesh_terms: D001145:Arrhythmias, Cardiac / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000208:ethnology*; D003327:Coronary Disease / Q000453:epidemiology; D006333:Heart Failure / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015995:Prevalence; D011634:Public Health; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000208:ethnology*; D020521:Stroke / Q000453:epidemiology
references.citation: N Engl J Med. 1993 Apr 29;328(17):1271-3
references.pmid: 8464440
references.citation: Sleep Med Rev. 2004 Aug;8(4):269-79
references.pmid: 15233955
references.citation: Circulation. 2012 Sep 18;126(12):1495-510
references.pmid: 22988046
references.citation: Sleep Med. 2001 Jan;2(1):47-55
references.pmid: 11152982
references.citation: Sleep. 2003 Feb 1;26(1):74-9
references.pmid: 12627736
references.citation: Thorax. 2000 Nov;55(11):934-9
references.pmid: 11050263
references.citation: J Appl Physiol (1985). 2001 Apr;90(4):1600-5
references.pmid: 11247966
references.citation: Am J Respir Crit Care Med. 2010 Jul 15;182(2):269-77
references.pmid: 20339144
references.citation: Sleep. 2004 May 1;27(3):453-8
references.pmid: 15164898
references.citation: J Clin Invest. 1995 Oct;96(4):1897-904
references.pmid: 7560081
references.citation: J Clin Hypertens (Greenwich). 2008 Oct;10(10):751-60
references.pmid: 19090876
references.citation: Essays Biochem. 2007;43:91-104
references.pmid: 17705795
references.citation: Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):375-80
references.pmid: 10673174
references.citation: J Clin Sleep Med. 2007 Jun 15;3(4):409-15
references.pmid: 17694731
references.citation: Thorax. 2001 Jul;56(7):505
references.pmid: 11413345
references.citation: N Engl J Med. 2005 Nov 10;353(19):2025-33
references.pmid: 16282177
references.citation: Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):339-49
references.pmid: 19110135
references.citation: Am J Physiol Cell Physiol. 2002 Feb;282(2):C227-41
references.pmid: 11788333
references.citation: Am J Respir Crit Care Med. 2001 Jan;163(1):19-25
references.pmid: 11208620
references.citation: Circulation. 2005 Mar 15;111(10):1233-41
references.pmid: 15769763
references.citation: Cochrane Database Syst Rev. 2006 Jan 25;(1):CD001106
references.pmid: 16437429
references.citation: Eur Respir J. 2003 Feb;21(2):241-7
references.pmid: 12608436
references.citation: Acta Otolaryngol Suppl. 2003;(550):32-5
references.pmid: 12737339
references.citation: Circulation. 2004 Jul 27;110(4):364-7
references.pmid: 15249509
references.citation: J Clin Hypertens (Greenwich). 2004 Jan;6(1):26-31; quiz 32-3
references.pmid: 14724421
references.citation: Sleep Med Rev. 2003 Feb;7(1):35-51
references.pmid: 12586529
references.citation: Am J Respir Crit Care Med. 2006 Apr 15;173(8):910-6
references.pmid: 16424443
references.citation: J Natl Med Assoc. 2011 Feb;103(2):86-98
references.pmid: 21443060
references.citation: Am J Respir Crit Care Med. 2009 Jul 1;180(1):36-41
references.pmid: 19406983
references.citation: Am J Cardiol. 1983 Sep 1;52(5):490-4
references.pmid: 6193700
references.citation: Am J Respir Crit Care Med. 1997 Jan;155(1):186-92
references.pmid: 9001310
references.citation: Am J Respir Crit Care Med. 2000 Dec;162(6):2166-71
references.pmid: 11112132
references.citation: J Hypertens. 2001 Dec;19(12):2271-7
references.pmid: 11725173
references.citation: Eur Heart J. 2004 May;25(9):728-34
references.pmid: 15120882
references.citation: Sleep. 2008 Jun;31(6):795-800
references.pmid: 18548823
references.citation: Respir Res. 2008 Jun 03;9:50
references.pmid: 18522716
references.citation: Lancet. 2005 Mar 19-25;365(9464):1046-53
references.pmid: 15781100
references.citation: Otolaryngol Head Neck Surg. 2006 Apr;134(4):545-50
references.pmid: 16564370
references.citation: N Engl J Med. 1993 Apr 29;328(17):1230-5
references.pmid: 8464434
references.citation: Circulation. 2010 Feb 23;121(7):948-54
references.pmid: 20177011
references.citation: Thorax. 2002 Jul;57(7):602-7
references.pmid: 12096203
references.citation: J Am Coll Cardiol. 2009 Nov 3;54(19):1797-804
references.pmid: 19874994
references.citation: JAMA. 2000 Apr 12;283(14):1829-36
references.pmid: 10770144
references.citation: J Hum Hypertens. 2005 Jun;19(6):485-90
references.pmid: 15800665
references.citation: Am J Respir Crit Care Med. 2005 Dec 1;172(11):1447-51
references.pmid: 16141444
references.citation: J Am Coll Cardiol. 2007 Feb 6;49(5):565-71
references.pmid: 17276180
references.citation: N Engl J Med. 2000 May 11;342(19):1378-84
references.pmid: 10805822
references.citation: Am J Respir Crit Care Med. 2002 May 1;165(9):1217-39
references.pmid: 11991871
references.citation: Sleep. 2010 Sep;33(9):1159-64
references.pmid: 20857861
references.citation: Circulation. 2003 May 27;107(20):2589-94
references.pmid: 12743002
references.citation: Sleep Med. 2012 Sep;13(8):1039-49
references.pmid: 22841028
references.citation: Arch Intern Med. 2002 Apr 22;162(8):893-900
references.pmid: 11966340
references.citation: J Am Coll Cardiol. 2007 May 22;49(20):2028-34
references.pmid: 17512359
references.citation: Circulation. 2005 Oct 25;112(17):2660-7
references.pmid: 16246965
references.citation: Circulation. 2010 Jul 27;122(4):352-60
references.pmid: 20625114
references.citation: Clin Cardiol. 1989 Dec;12(12 Suppl 4):IV13-7
references.pmid: 2620468
references.citation: Am J Cardiol. 2007 Jan 1;99(1):26-30
references.pmid: 17196456
references.citation: Am J Cardiol. 2011 Jul 1;108(1):47-51
references.pmid: 21529734
references.citation: Proc Am Thorac Soc. 2008 Feb 15;5(2):136-43
references.pmid: 18250205
references.citation: Eur Heart J. 2004 Jun;25(12):1070-6
references.pmid: 15191779
references.citation: J Am Coll Cardiol. 2007 Oct 2;50(14):1310-4
references.pmid: 17903628
references.citation: Am J Respir Crit Care Med. 2007 Dec 15;176(12):1274-80
references.pmid: 17673692
references.citation: Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):1946-9
references.pmid: 8520760
references.citation: Am Heart J. 2008 Mar;155(3):501-6
references.pmid: 18294487
references.citation: N Engl J Med. 2005 Nov 10;353(19):2034-41
references.pmid: 16282178
references.citation: J Cardiovasc Electrophysiol. 2008 Sep;19(9):997-1003
references.pmid: 18373598
references.citation: Am J Respir Crit Care Med. 2009 Jun 15;179(12):1159-64
references.pmid: 19264976
references.citation: Sleep. 1999 Sep 15;22(6):749-55
references.pmid: 10505820
references.citation: N Engl J Med. 2003 Mar 27;348(13):1233-41
references.pmid: 12660387
references.citation: Circulation. 2003 Feb 11;107(5):727-32
references.pmid: 12578876
references.citation: Circulation. 2000 Feb 1;101(4):392-7
references.pmid: 10653830
references.citation: Sleep. 1997 Jan;20(1):65-76
references.pmid: 9130337
references.citation: JAMA. 2012 May 23;307(20):2169-76
references.pmid: 22618924
references.citation: Sleep. 2009 Feb;32(2):135-6
references.pmid: 19238798
references.citation: Int J Cardiol. 2006 Jan 4;106(1):21-8
references.pmid: 16321661
references.citation: Circulation. 2012 Jan 3;125(1):188-97
references.pmid: 22215894
references.citation: Cardiology. 1999;92(2):79-84
references.pmid: 10702648
references.citation: Lancet. 2002 Jan 19;359(9302):204-10
references.pmid: 11812555
references.citation: Circulation. 2011 Mar 29;123(12):1280-6
references.pmid: 21403097