title: Long lived NMR signal in bone.
abstract: Solids and rigid tissues, such as bone, ligaments, and tendons, typically appear dark in MRI, which is due to the extremely short-lived proton nuclear magnetic resonance signals. This short lifetime is due to strong dipolar interactions between immobilized proton spins, which render it challenging to detect these signals with sufficient resolution and sensitivity. Here we show the possibility of exciting long-lived signals in cortical bone tissue with a signature consistent with that of bound water signals. It is further shown that dipolar coupling networks are an integral requirement for the excitation of these long-lived signals. The use of these signals could enhance the ability to visualize rigid tissues and solid samples with high resolution and sensitivity via MRI.
authors.affiliation: Chemistry Department, New York University, New York, NY 10003, USA.
authors.forename: Boyang
authors.initials: B
authors.lastname: Zhang
authors.forename: Jae-Seung
authors.initials: JS
authors.lastname: Lee
authors.forename: Anatoly
authors.initials: A
authors.lastname: Khitrin
authors.forename: Alexej
authors.initials: A
authors.lastname: Jerschow
mesh_terms: D000465:Algorithms; D000818:Animals; D002417:Cattle; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels; D013977:Tibia / Q000033:anatomy & histology* / Q000737:chemistry*
chemical_list: D013113:Spin Labels
references.citation: NMR Biomed. 2011 Aug;24(7):855-64
references.pmid: 21274960
references.citation: Ann Biomed Eng. 2005 Jan;33(1):79-86
references.pmid: 15709708
references.citation: Phys Chem Chem Phys. 2012 Jan 7;14(1):86-9
references.pmid: 22086134
references.citation: NMR Biomed. 2008 Jan;21(1):59-70
references.pmid: 17506113
references.citation: Acad Radiol. 2008 Dec;15(12):1482-93
references.pmid: 19000865
references.citation: Magn Reson Imaging. 2004 May;22(4):573-82
references.pmid: 15120178
references.citation: J Magn Reson Imaging. 2010 Apr;31(4):954-63
references.pmid: 20373441
references.citation: J Chem Phys. 2011 Apr 21;134(15):154502
references.pmid: 21513390
references.citation: Radiology. 1991 Jun;179(3):777-81
references.pmid: 2027991
references.citation: Magn Reson Med. 2009 May;61(5):1114-21
references.pmid: 19215044
references.citation: Magn Reson Med. 1997 Dec;38(6):1022-8
references.pmid: 9402205
references.citation: Magn Reson Med. 2010 Sep;64(3):680-7
references.pmid: 20806375
references.citation: Magn Reson Med. 1997 Apr;37(4):494-500
references.pmid: 9094070
references.citation: J Magn Reson. 2011 Dec;213(1):22-5
references.pmid: 21920788
references.citation: Radiology. 2008 Sep;248(3):824-33
references.pmid: 18632530
references.citation: AJR Am J Roentgenol. 2009 Mar;192(3):W117-24
references.pmid: 19234239
references.citation: Top Magn Reson Imaging. 2010 Oct;21(5):275-89
references.pmid: 22129641