title: Postmenopausal osteoporosis: Our experience.
abstract: BACKGROUND
  There is very little published literature about experience with osteoporosis treatment from our country.
  
  
  METHODS
  It is a retrospective analysis of first 50 patients enrolled in our clinic for osteoporosis. Postmenopausal women with T score of less than -2.5 or history suggestive fragility fracture with supportive bone mineral density (BMD) were included. Patients having hypercalcemia, abnormal renal function, myeloma and on long-term steroids were also excluded.
  
  
  RESULTS
  Nearly 34% subjects were below the age of 60 years, 47% of subjects were between 60 and 70 years, whereas 18% were above 70 years. Nearly 6% had family history of osteoporosis s or history of osteoporotic fractures. Nearly 20% subjects had fracture prior to starting of any treatment. A total of 86% (40/46) had evidence of Vitamin D (VD) deficiency. Nearly 80% of patients were treated with bisphosphonates, 12% were treated with injectable bisphosphonates, and 8% were treated with teriperatide. Nearly 16% patients had duration of more than 5 years of experience with bisphosphonates. Follow up BMD was available in 25 subjects. BMD had improved significantly in 68% of subjects. In 24% the BMD was stable (the change was less than least significant change (LSC)). In 8% BMD had shown a significant decline while being on treatment.
  
  
  CONCLUSIONS
  Postmenopausal osteoporosis occurs in relatively younger women in our country. Majority of them are VD deficient. Oral bisphosphonates is the most common used drug; it is fairly well tolerated and effective.
authors.affiliation: Department of Endocrinology, Neursosurgery, Apollo Hospital, Jubilee Hills, Hyderabad, AP, India.
authors.forename: R N
authors.initials: RN
authors.lastname: Mehrotra
authors.forename: Alok
authors.initials: A
authors.lastname: Ranjan
authors.forename: Rahul
authors.initials: R
authors.lastname: Lath
authors.forename: R
authors.initials: R
authors.lastname: Ratnam
keywords: Post menopausal osteoporosis; bisphosphonates; bone mineral density
references.citation: Am J Med. 2006 Apr;119(4 Suppl 1):S25-31
references.pmid: 16563938
references.citation: J Clin Densitom. 2011 Jul-Sep;14(3):237-9
references.pmid: 21810531