title: [A case of pancreatic neuroendocrine tumor with excessively-advanced liver metastasis treated with S-1/GEM combination chemotherapy plus the long-acting somatostatin analogue octreotide].
abstract: A 41-year-old woman who had a pancreatic tail tumor and multiple liver tumors was referred to our hospital. The results of abdominal US, CT and MRI, and histopathological and immunohistochemical findings of the liver tumor biopsy revealed a pancreatic neuroendocrine tumor with excessively-advanced liver metastasis. We treated her with S-1/gemcitabine combination chemotherapy plus long-acting somatostatin analogue octreotide, which produced tumor stabilization and good quality of life for 7 months, and survival time of 15 months. Although the tumor was diagnosed as a poorly differentiated endocrine carcinoma, this therapy was suggested to be effective in this case.
authors.affiliation: Department of Internal Medicine, Sapporo Dohto Hospital. yoshida-yu@kouwakai.or.jp
authors.forename: Yukinari
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Sugawara
authors.forename: Takae
authors.initials: T
authors.lastname: Minami
authors.forename: Norikazu
authors.initials: N
authors.lastname: Iwata
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ikeda
authors.forename: Takao
authors.initials: T
authors.lastname: Endoh
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D018358:Neuroendocrine Tumors / Q000188:drug therapy* / Q000473:pathology*; D015282:Octreotide / Q000008:administration & dosage*; D010094:Oxonic Acid / Q000008:administration & dosage*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D005641:Tegafur / Q000008:administration & dosage*; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D018931:Antineoplastic Agents, Hormonal; D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D015282:Octreotide; D000093542:Gemcitabine