title: Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.
abstract: BACKGROUND
  Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown.
  
  
  OBJECTIVE
  Test associations of endothelial biomarkers with FEV1 using instrumental variables.
  
  
  METHODS
  Among 26 907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets.
  
  
  RESULTS
  ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29 mL and -34 mL per standard deviation of log-transformed biomarker, p < 0.001), as was endothelin-1 among African-Americans (-22 mL, p = 0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative.
  
  
  CONCLUSIONS
  Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. eco7@columbia.edu
authors.forename: E C
authors.initials: EC
authors.lastname: Oelsner
authors.forename: T D
authors.initials: TD
authors.lastname: Pottinger
authors.forename: K M
authors.initials: KM
authors.lastname: Burkart
authors.forename: M
authors.initials: M
authors.lastname: Allison
authors.forename: S G
authors.initials: SG
authors.lastname: Buxbaum
authors.forename: N N
authors.initials: NN
authors.lastname: Hansel
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: E K
authors.initials: EK
authors.lastname: Larkin
authors.forename: L A
authors.initials: LA
authors.lastname: Lange
authors.forename: L R
authors.initials: LR
authors.lastname: Loehr
authors.forename: S J
authors.initials: SJ
authors.lastname: London
authors.forename: G T
authors.initials: GT
authors.lastname: O'Connor
authors.forename: G
authors.initials: G
authors.lastname: Papanicolaou
authors.forename: M F
authors.initials: MF
authors.lastname: Petrini
authors.forename: D
authors.initials: D
authors.lastname: Rabinowitz
authors.forename: S
authors.initials: S
authors.lastname: Raghavan
authors.forename: S
authors.initials: S
authors.lastname: Redline
authors.forename: B
authors.initials: B
authors.lastname: Thyagarajan
authors.forename: R P
authors.initials: RP
authors.lastname: Tracy
authors.forename: J B
authors.initials: JB
authors.lastname: Wilk
authors.forename: W B
authors.initials: WB
authors.lastname: White
authors.forename: S S
authors.initials: SS
authors.lastname: Rich
authors.forename: R G
authors.initials: RG
authors.lastname: Barr
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D044383:Black People; D015331:Cohort Studies; D019040:E-Selectin / Q000235:genetics / Q000378:metabolism; D019332:Endothelin-1 / Q000235:genetics / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism; D008168:Lung / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000235:genetics / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D012129:Respiratory Function Tests; D013147:Spirometry; D044465:White People; D001741:Black or African American
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D019332:Endothelin-1; D019007:P-Selectin; C546936:SELE protein, human; D018799:Intercellular Adhesion Molecule-1
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