title: Importance of reverse signaling of the TNF superfamily in immune regulation.
abstract: TNF-related ligands (with the exception of lymphotoxin-α) are synthesized as type II transmembrane proteins, though many of them also have soluble forms. An increasing number of publications report that these 'ligands' behave as receptors, activating intracellular signaling pathways when interacting with cognate 'receptors' or agonistic antibodies. Most members of the TNF family and their receptors influence survival, proliferation, differentiation or activation of immune cells. The elicited 'reverse signals' also have significant importance. They proved to be involved in the activation of APCs, T and B cells, differentiation of osteoclasts and apoptosis of activated macrophages. They influence the balance between destructive immune response and tolerance. Several examples show that therapeutic manipulation of the reverse signal can help to treat malignancies as well as autoimmune disorders.
authors.affiliation: Biological Research Center of the Hungarian Academy of Sciences, Temesvári 62, 6726 Szeged, Hungary.
authors.forename: Kata
authors.initials: K
authors.lastname: Juhász
authors.forename: Krisztina
authors.initials: K
authors.lastname: Buzás
authors.forename: Ernő
authors.initials: E
authors.lastname: Duda
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D025461:Feedback, Physiological; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D007167:Immunotherapy; D008213:Lymphocyte Activation; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: D014409:Tumor Necrosis Factor-alpha