title: Estimation of fast and slow wave properties in cancellous bone using Prony's method and curve fitting.
abstract: The presence of two longitudinal waves in poroelastic media is predicted by Biot's theory and has been confirmed experimentally in through-transmission measurements in cancellous bone. Estimation of attenuation coefficients and velocities of the two waves is challenging when the two waves overlap in time. The modified least squares Prony's (MLSP) method in conjuction with curve-fitting (MLSP + CF) is tested using simulations based on published values for fast and slow wave attenuation coefficients and velocities in cancellous bone from several studies in bovine femur, human femur, and human calcaneus. The search algorithm is accelerated by exploiting correlations among search parameters. The performance of the algorithm is evaluated as a function of signal-to-noise ratio (SNR). For a typical experimental SNR (40 dB), the root-mean-square errors (RMSEs) for one example (human femur) with fast and slow waves separated by approximately half of a pulse duration were 1 m/s (slow wave velocity), 4 m/s (fast wave velocity), 0.4 dB/cm MHz (slow wave attenuation slope), and 1.7 dB/cm MHz (fast wave attenuation slope). The MLSP + CF method is fast (requiring less than 2 s at SNR = 40 dB on a consumer-grade notebook computer) and is flexible with respect to the functional form of the parametric model for the transmission coefficient. The MLSP + CF method provides sufficient accuracy and precision for many applications such that experimental error is a greater limiting factor than estimation error.
authors.affiliation: U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Room 3108, Silver Spring, Maryland 20993-0002, USA. keith.wear@fda.hhs.gov
authors.forename: Keith A
authors.initials: KA
authors.lastname: Wear
mesh_terms: D000465:Algorithms; D000818:Animals; D015519:Bone Density; D002111:Calcaneus / Q000000981:diagnostic imaging*; D002417:Cattle; D003198:Computer Simulation; D004548:Elasticity; D005269:Femur / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D016018:Least-Squares Analysis; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D016062:Porosity; D059629:Signal-To-Noise Ratio; D013997:Time Factors; D014465:Ultrasonics / Q000379:methods*; D014463:Ultrasonography
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