title: Waist circumference, not body mass index, is associated with renal function decline in korean population: hallym aging study.
abstract: BACKGROUND
  Prospective investigation of obesity and renal function decline in Asia is sparse. We examined the associations of body mass index (BMI) and waist circumference (WC) with renal function decline in a prospective study of Korean population.
  
  
  METHODS
  A total of 454 participants who had baseline estimated glomerular filtration rate (eGFR) levels of more than 60 mL/min/1.73 m(2) in Hallym Aging Study (HAS) were included and followed for 6 years. Renal function decline was defined as follows: (1) an eGFR decline ≥3 mL/min/1.73 m(2)/year (n = 82 cases); (2) an eGFR decrease of 20% or greater (n = 87 cases) at follow-up; (3) an eGFR decrease of 20% greater at follow-up or eGFR decline ≥3 mL/min/1.73 m(2)/year (n = 91 cases); and (4) an eGFR <60 mL/min/1.73 m(2) at follow-up (n = 54 cases). eGFR was determined based on the Modification of Diet in Renal Disease (MDRD) Study equation. Multivariate logistic regression model was used to determine the association between obesity and renal function decline.
  
  
  RESULTS
  We found that central obesity was associated with faster renal function decline. Comparing WC of >95 cm in men or >90 cm in women with ≤90 cm in men or ≤85 cm in women, ORs (95% CIs) ranged from 2.31 (1.14-4.69) to 2.78 (1.19-6.50) for the 4 definitions of renal function decline (all p-values for trend <0.05). Waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) also was associated with renal function decline. There was no significant association of BMI with renal function decline.
  
  
  CONCLUSIONS
  Central obesity, but not BMI, is associated with faster renal function decline in Korean population. Our results provide important evidence that simple measurement of central fat deposition rather than BMI could predict decline in renal function in Korean population.
authors.affiliation: Department of Food and Nutrition, Sookmyung Women's University, Seoul, Korea.
authors.forename: Hyunju
authors.initials: H
authors.lastname: Oh
authors.forename: Shan Ai
authors.initials: SA
authors.lastname: Quan
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Jeong
authors.forename: Soong-Nang
authors.initials: SN
authors.lastname: Jang
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
mesh_terms: D000367:Age Factors; D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology* / Q000503:physiopathology*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000150:complications; D016017:Odds Ratio; D011446:Prospective Studies; D056910:Republic of Korea; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D003404:Creatinine
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