title: Nutraceuticals as new treatment approaches for oral cancer: II. Green tea extracts and resveratrol.
abstract: Nutraceuticals with anti-neoplastic potential are suitable candidates for extending the range of therapeutic options for several types of cancers. One of these malignancies is oral cancer of the squamous cell carcinoma type, for which current treatment approaches have not succeeded in improving long-term clinical outcome. We recently reviewed the beneficial effects of curcumin for the treatment of oral cancer. In the current review, we focused on the beneficial effects of other two nutraceuticals, green tea extracts [especially (-)-epigallocatechin-3-gallate (EGCG)] and resveratrol, in the treatment of oral cancer. In vivo and in vitro studies as well as clinical trials were reviewed, focusing on the beneficial effect of each of these plant-derived dietary agents, either alone or in combination with various pharmacological agents. We also presented the anti-cancer effects against cancer cells and against components of the tumor microenvironment. It emerged that the poor bioavailability of these nutraceuticals poses an obstacle to their exerting adequate anti-cancer potential. Ground-breaking studies employing new nanotechnology-based therapeutic approaches were presented.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel.
authors.forename: Ayelet
authors.initials: A
authors.lastname: Zlotogorski
authors.forename: Aliza
authors.initials: A
authors.lastname: Dayan
authors.forename: Dan
authors.initials: D
authors.lastname: Dayan
authors.forename: Gavriel
authors.initials: G
authors.lastname: Chaushu
authors.forename: Tuula
authors.initials: T
authors.lastname: Salo
authors.forename: Marilena
authors.initials: M
authors.lastname: Vered
mesh_terms: D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019587:Dietary Supplements; D006801:Humans; D051379:Mice; D009062:Mouth Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D013662:Tea / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D013267:Stilbenes; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; D000077185:Resveratrol