title: Effect of caffeic acid phenethyl ester on intra-abdominal adhesion in rats.
abstract: BACKGROUND
  To determine the impact of caffeic acid phenethyl ester (CAPE) on abdominal adhesion formation after laparotomy.
  
  
  METHODS
  Forty female rats were allocated into four distinct groups on which laparotomy alone; laparotomy with traumatization of the uterine horns; laparotomy, traumatization of the uterine horns and intraperitoneal irrigation with saline, and laparotomy, traumatization of the uterine horns and intraperitoneal irrigation with CAPE were performed. After sacrifying the animals on the 14th postoperative day, histopathological examination and biochemical analysis were conducted to evaluate the formation of abdominal adhesions and antioxidant status.
  
  
  RESULTS
  In the CAPE group, total adhesion scores were significantly lower than in the control and saline groups. The CAPE group displayed less inflammation, giant cell formation, fibrosis and fibroblastic activity than the control group. On the other hand, the control group displayed higher total adhesion scores.
  
  
  CONCLUSIONS
  The results of this study indicate that the administration of CAPE may have beneficial effects for the prevention of abdominal adhesion formation after laparotomy. Further clinical studies are mandatory to explore the actual therapeutic potential of CAPE.
authors.affiliation: Department of Obstetrics and Gynecology, Dicle University School of Medicine, TR- 21280 Diyarbakir, Turkey. abdulkadirturgut@gmail.com
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Turgut
authors.forename: Muhammet Erdal
authors.initials: ME
authors.lastname: Sak
authors.forename: Gul
authors.initials: G
authors.lastname: Turkcu
authors.forename: Ali
authors.initials: A
authors.lastname: Ozler
authors.forename: Hatice Ender
authors.initials: HE
authors.lastname: Soydinc
authors.forename: Mehmet Siddik
authors.initials: MS
authors.lastname: Evsen
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: Fatih
authors.initials: F
authors.lastname: Akdemir
mesh_terms: D034841:Abdominal Cavity / Q000601:surgery; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002109:Caffeic Acids / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D007263:Infusions, Parenteral; D007813:Laparotomy / Q000009:adverse effects*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D000267:Tissue Adhesions / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D014599:Uterus / Q000601:surgery*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol