title: [Calcium dependent signaling in cardiac hypertrophy and cell death].
abstract: Ca(2 +) plays a pivotal role in excitation-contraction coupling as well as activation of Ca(2 +) -dependent signaling pathways in the myocardium. The two main established Ca(2 +) -dependent pathways during cardiomyocyte hypertrophy are the Ca(2 +) /calmodulin-calcineurin-NFAT and the Ca(2 +) /calmodulin dependent kinases II -HDAC-MEF2. Both pathways are involved in the transcriptional control of many hypertrophic genes. Recently, cyclophilin D, an immunophilin located on mitochondrial inner membrane, has been highlighted as a regulator of calcium-mediated mitochondrial permeability transition in necrotic cardiac cell death.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujio
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002147:Calmodulin / Q000378:metabolism; D006332:Cardiomegaly / Q000378:metabolism* / Q000473:pathology; D016923:Cell Death; D006801:Humans
chemical_list: D002147:Calmodulin; D002118:Calcium