title: Association between interleukin 10 gene -1082 A/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis of 4250 subjects.
abstract: Increasing evidence suggests that interleukin 10 (IL 10) gene -1082 A/G (rsl800896) polymorphism may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the results are inconsistent. The aim of this study is to analyze the association between this variant and the T2DM risk by meta-analysis. PubMed, Embase, Web of Science, and Google Scholar were searched from January 1, 1989 to February 17, 2012, as well as hand searching of the references of identified articles were performed. All the statistical tests were performed using Stata 11.0. Seven case-control studies were identified, covering a total of 1879 T2DM cases and 2371 controls. The results showed evidence of significant association between IL 10 gene -1082 A/G polymorphism and T2DM risk (for G/G+G/A vs. A/A: OR=1.21, 95% CI=1.05-1.40, p=0.010, p=0.040 after Bonferroni testing). In the subgroup analysis by ethnicity, no significant association was found between IL 10 gene -1082 A/G polymorphism and T2DM risk in Europeans. In summary, results from this meta-analysis provide evidence that IL 10 gene -1082 G allele is associated with increased risk of T2DM.
authors.affiliation: Department of Emergency, Chinese PLA Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing 100142, China. shuaishuaijita@sohu.com
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Yin
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Hu
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Sun
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Zhang
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Zeng
authors.forename: Rui-Jia
authors.initials: RJ
authors.lastname: Xu
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Zhang
authors.forename: Long-Bao
authors.initials: LB
authors.lastname: Shi
mesh_terms: D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D016753:Interleukin-10