title: Tc-99m glucoheptonate is poor man's fluorodeoxyglucose.
abstract: While fluoro-deoxy-glucose (FDG) has emerged as an important radiotracer for imaging tumors, myocardial viability and infection, the role of other glucose analogues should also be explored. Tc-99m Glucoheptonate (GHA) has been used for imaging brain tumors and lung tumors. The uptake mechanism may be linked to GLUT-1 (Glucose transporter) and GLUT-4 expression similar to FDG. GHA is easily available and cheap. With the availability of single photon emission computed tomography/computed tomography (SPECT/CT), GHA imaging should be re-explored as a tumor agent and also for imaging myocardial viability.
authors.affiliation: Department of Nuclear Medicine and Radioimmunoassay, Lilavati Hospital and Research Centre, Department of Nuclear Medicine and PET-CT, Jaslok Hospital and Research Centre, Mumbai, India.
authors.forename: Ramchandra D
authors.initials: RD
authors.lastname: Lele
keywords: PET-CT; SPECT-CT; Tc-99m Glucoheptonate; fluoro-deoxy-glucose
references.citation: Cancer. 1993 Nov 15;72(10):2979-85
references.pmid: 8221565
references.citation: J Nucl Med. 1975 Oct;16(10):875-8
references.pmid: 1177016
references.citation: Circulation. 1992 Dec;86(6):1671-91
references.pmid: 1451239
references.citation: J Nucl Cardiol. 2008 Sep-Oct;15(5):617-30
references.pmid: 18761264
references.citation: J Nucl Med. 1992 Jul;33(7):1346-53
references.pmid: 1613576
references.citation: J Nucl Med. 1981 Aug;22(8):703-9
references.pmid: 7264760
references.citation: J Nucl Med. 2001 Oct;42(10):1551-5
references.pmid: 11585872
references.citation: J Biol Chem. 1999 Apr 30;274(18):12567-75
references.pmid: 10212235
references.citation: J Nucl Med. 1993 Mar;34(3):419-21
references.pmid: 8441033
references.citation: J Nucl Med. 1977 Oct;18(10):1037
references.pmid: 903470
references.citation: Diabetes Care. 1990 Mar;13(3):198-208
references.pmid: 2407475
references.citation: J Nucl Med. 1983 Nov;24(11):997-1000
references.pmid: 6313880
references.citation: J Clin Oncol. 1984 Sep;2(9):1017-24
references.pmid: 6088707
references.citation: J Clin Invest. 1988 Dec;82(6):2017-25
references.pmid: 3198763
references.citation: Circulation. 2003 Sep 9;108(10):1208-13
references.pmid: 12939208
references.citation: Science. 1987 Mar 20;235(4795):1492-5
references.pmid: 3103217
references.citation: J Biol Chem. 2000 Apr 21;275(16):11981-6
references.pmid: 10766828
references.citation: Clin Nucl Med. 1983 Jan;8(1):31-3
references.pmid: 6339148
references.citation: Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7313-8
references.pmid: 10860996
references.citation: Circulation. 1997 Jan 21;95(2):415-22
references.pmid: 9008459
references.citation: Cardiovasc Res. 1992 Dec;26(12):1172-80
references.pmid: 1288863
references.citation: Curr Probl Cardiol. 1994 Feb;19(2):59-113
references.pmid: 8174388
references.citation: J Mol Cell Cardiol. 1999 Jul;31(7):1337-44
references.pmid: 10403751
references.citation: Circulation. 1998 May 12;97(18):1848-67
references.pmid: 9603540
references.citation: J Mol Cell Cardiol. 1999 Feb;31(2):435-43
references.pmid: 10093055
references.citation: J Nucl Med. 2008 Jun;49 Suppl 2:129S-48S
references.pmid: 18523070
references.citation: Eur J Nucl Med. 1996 Oct;23(10):1409-15
references.pmid: 8781149
references.citation: Nucl Med Biol. 1996 Aug;23(6):717-35
references.pmid: 8940714
references.citation: Am J Physiol. 1987 Jul;253(1 Pt 2):H107-14
references.pmid: 3605356
references.citation: Nucl Med Commun. 1998 Feb;19(2):97-105
references.pmid: 9548192
references.citation: J Nucl Med. 1982 Mar;23(3):250-4
references.pmid: 6278110
references.citation: Circulation. 1997 Nov 4;96(9):2920-31
references.pmid: 9386158
references.citation: J Nucl Med. 1975 Nov;16(11):980-5
references.pmid: 1185277
references.citation: J Am Coll Cardiol. 1997 Nov 1;30(5):1407-12
references.pmid: 9350947
references.citation: Eur J Nucl Med Mol Imaging. 2011 Jul;38(7):1189-90
references.pmid: 21400010
references.citation: J Nucl Med. 1992 Jul;33(7):1255-62
references.pmid: 1613561
references.citation: Appl Radiat Isot. 2011 Jul;69(7):955-9
references.pmid: 21459007
references.citation: J Nucl Med. 1975 May;16(5):357-67
references.pmid: 1194986
references.citation: J Mol Cell Cardiol. 1997 Jun;29(6):1675-85
references.pmid: 9220353
references.citation: J Nucl Med. 1977 Oct;18(10):957-61
references.pmid: 903478
references.citation: J Biol Chem. 1988 Dec 25;263(36):19447-54
references.pmid: 3058699
references.citation: Am Heart J. 1989 Jan;117(1):211-21
references.pmid: 2783527
references.citation: Circulation. 1994 Nov;90(5):2356-66
references.pmid: 7955194
references.citation: Int J Rad Appl Instrum B. 1987;14(3):191-204
references.pmid: 3499422
references.citation: Curr Genomics. 2007 Apr;8(2):113-28
references.pmid: 18660845
references.citation: J Nucl Med. 1987 Jan;28(1):47-52
references.pmid: 3467030
references.citation: Annu Rev Physiol. 1974;36:413-59
references.pmid: 19400669
references.citation: Cancer Res. 1999 Sep 15;59(18):4709-14
references.pmid: 10493529
references.citation: Semin Nucl Med. 1985 Apr;15(2):171-200
references.pmid: 2988131
references.citation: Histol Histopathol. 2005 Oct;20(4):1327-38
references.pmid: 16136514
references.citation: Circ Res. 1996 Mar;78(3):455-65
references.pmid: 8593704
references.citation: J Am Coll Cardiol. 1989 Mar 1;13(3):745-54
references.pmid: 2918181
references.citation: Prog Cardiovasc Dis. 1981 Mar-Apr;23(5):321-36
references.pmid: 7012926