title: Status of neurocognitive and oxidative stress conditions in iron-steel workers.
abstract: The aim of this study was to determine oxidative stress status as well as ferrous (Fe) and Copper (Cu) levels in blood, neurocognitive impairment, and clinical markers in iron-steel workers. A comparative cross-sectional analysis was performed in 50 iron-steel workers who have been in contact with Fe and Cu in comparison with a control group containing 50 healthy subjects in the same age group and sex. Blood levels of lipid peroxidation, total antioxidant capacity, Fe, and Cu along with neurocognitive impairment were measured in workers and controls. Clinical examination was accomplished to record any abnormal sign or symptoms. Comparing with controls, the workers showed higher blood levels of lipid peroxidation and Cu and also a lower total antioxidant capacity. There was a positive correlation between work history and interstitial lung disease that strengths the presumption to progress to chronic obstructive lung disease in future. The results indicate that exposure to a combination of Fe and Cu in iron-steel workers induces oxidative stress. Especially, in the present case, toxic effect of Cu has been more than positive effects of Fe, but the combined exposure resulted in no such critical toxicity.
authors.affiliation: Biology Department, Payame Noor University, Iran Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Malekirad
authors.affiliation: Biology Department, Payame Noor University, Iran.
authors.forename: Mansuoreh
authors.initials: M
authors.lastname: Mirabdollahi
authors.affiliation: Biology Department, Payame Noor University, Iran.
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Pilehvarian
authors.affiliation: Biology Department, Payame Noor University, Iran.
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Nassajpour
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Science, Tehran, Iran mohammad.abdollahi@utoronto.ca.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D003300:Copper / Q000097:blood*; D003430:Cross-Sectional Studies; D006801:Humans; D007221:Industry; D007492:Iran / Q000453:epidemiology; D007501:Iron / Q000097:blood*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D019965:Neurocognitive Disorders / Q000139:chemically induced / Q000453:epidemiology; D016273:Occupational Exposure / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects*; D013232:Steel; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D013232:Steel; D003300:Copper; D007501:Iron
keywords: Ferrous; copper; iron–steel workers; oxidative stress; toxicity