title: One-pot and regiospecific synthesis of 2,3-disubstituted indoles from 2-bromoanilides via consecutive palladium-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.
abstract: A practical one-pot and regiospecific three-component process for the synthesis of 2,3-disubstituted indoles from 2-bromoanilides was developed via consecutive palladium-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.
authors.affiliation: Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States. bruce.lu@boehringer-ingelheim.com
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Lu
authors.forename: Han-Xun
authors.initials: HX
authors.lastname: Wei
authors.forename: Yongda
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wenyi
authors.initials: W
authors.lastname: Zhao
authors.forename: Marine
authors.initials: M
authors.lastname: Dufour
authors.forename: Guisheng
authors.initials: G
authors.lastname: Li
authors.forename: Vittorio
authors.initials: V
authors.lastname: Farina
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D000577:Amides / Q000737:chemistry*; D000813:Anilides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D000577:Amides; D000813:Anilides; D006842:Hydrocarbons, Brominated; D007211:Indoles; D009942:Organometallic Compounds; D010165:Palladium