title: Procollagen Type I C-terminal propeptide, procollagen Type III N-terminal propeptide, hyaluronic acid, and laminin in the cerebrospinal fluid of rats with communicating hydrocephalus.
abstract: OBJECTIVE
  Fibrosis along the route of CSF flow is indicated by the development of hydrocephalus. The changes of fibrosis index might reflect the level of hydrocephalus and even become a diagnostic index of hydrocephalus. The object of this study was to analyze the levels of procollagen Type I C-terminal propeptide (PICP), procollagen Type III N-terminal propeptide (PIIINP), hyaluronic acid (HA), and laminin (LN) and their significance in the CSF of communicating hydrocephalus rat models.
  
  
  METHODS
  Thirty adult Sprague-Dawley rats were randomly divided into 3 groups: hydrocephalus group (20 rats) with intraventricular kaolin injections, sham control group (5 rats) with saline injections, and normal group (5 rats) without any processing. The levels of PICP, PIIINP, HA, and LN in the CSF were detected using ELISA.
  
  
  RESULTS
  Levels of PICP, PIIINP, HA, and LN in the hydrocephalus group were significantly higher than those in the saline control group (p < 0.05). It was revealed by correlation analysis that the increase was positively correlated with the severity of ventricular dilation.
  
  
  CONCLUSIONS
  Results indicated that PICP, PIIINP, HA, and LN continue to rise dramatically in experimental hydrocephalus and may serve as the diagnostic index of hydrocephalus.
authors.affiliation: Department of Neurosurgery, First Affiliate Hospital of Xiamen University, Xiamen, Fujian Province, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.forename: Zhanxiang
authors.initials: Z
authors.lastname: Wang
authors.forename: Shaolin
authors.initials: S
authors.lastname: Zhang
authors.forename: Guowei
authors.initials: G
authors.lastname: Tan
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D006820:Hyaluronic Acid / Q000134:cerebrospinal fluid*; D006849:Hydrocephalus / Q000134:cerebrospinal fluid*; D007797:Laminin / Q000134:cerebrospinal fluid*; D008297:Male; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D011347:Procollagen / Q000134:cerebrospinal fluid*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D007797:Laminin; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; C042813:procollagen type I carboxy terminal peptide; D006820:Hyaluronic Acid