title: Inpp4b is a novel negative modulator of osteoclast differentiation and a prognostic locus for human osteoporosis.
abstract: Inositol polyphosphate 4-phosphatase type II (Inpp4b) is a novel negative modulator of osteoclast differentiation and a prognostic locus for human osteoporosis. This short overview summarizes some of the cellular, molecular, and crosstalk signaling mechanisms that control osteoclast and osteoblast differentiation and activation.
authors.affiliation: Clinical Research Institute of Montreal, Départment de Médecine, Université de Montréal, Department of Medicine, McGill University, Montréal, Québec, Canada. vacherj@ircm.qc.ca
authors.forename: Jean
authors.initials: J
authors.lastname: Vacher
mesh_terms: D002454:Cell Differentiation; D006801:Humans; D010006:Osteoblasts / Q000166:cytology / Q000201:enzymology; D010010:Osteoclasts / Q000166:cytology* / Q000201:enzymology; D010024:Osteoporosis / Q000201:enzymology* / Q000473:pathology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D010744:Phosphoric Monoester Hydrolases; C053153:phosphatidylinositol-3,4-bisphosphate 4-phosphatase