title: One-pot high-throughput synthesis of a 160-membered library of methyl 3,5-diaryl-isoxazoline-5-carboxylate pharmacophores by a 2·2·2-component reaction.
abstract: A simple and efficient methodology has been developed for the synthesis of methyl 3,5-diaryl-isoxazoline-5-carboxylates in a high-throughput fashion. This was accomplished in one-pot by a sequence of three 2-component reactions steps (2·2·2-CR), whereby compounds were obtained in overall 30-66% isolated yields. The functional group diversity was established by synthesizing a 160-membered library.
authors.affiliation: Jubilant Chemsys Ltd. , B-34, Sector-58, Noida, UP, India-201301.
authors.forename: Kallolmay
authors.initials: K
authors.lastname: Biswas
authors.forename: Arvind
authors.initials: A
authors.lastname: Kumar
authors.forename: Koushik
authors.initials: K
authors.lastname: Das Sarma
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D010080:Oxazoles