title: Comparison of titanium soaked in 5 M NaOH or 5 M KOH solutions.
abstract: Commercially pure titanium plates/coupons and pure titanium powders were soaked for 24 h in 5 M NaOH and 5 M KOH solutions, under identical conditions, over the temperature range of 37° to 90 °C. Wettability of the surfaces of alkali-treated cpTi coupons was studied by using contact angle goniometry. cpTi coupons soaked in 5 M NaOH or 5 M KOH solutions were found to have hydrophilic surfaces. Hydrous alkali titanate nanofibers and nanotubes were identified with SEM/EDXS and grazing incidence XRD. Surface areas of Ti powders increased > 50–220 times, depending on the treatment, when soaked in the above solutions. A solution was developed to coat amorphous calcium phosphate, instead of hydroxyapatite, on Ti coupon surfaces. In vitro cell culture tests were performed with osteoblast-like cells on the alkali-treated samples.
authors.affiliation: Oklahoma School of Science and Mathematics, Oklahoma City, OK 73104, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Kim
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Kendall
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Miller
authors.forename: Courtney L
authors.initials: CL
authors.lastname: Long
authors.forename: Preston R
authors.initials: PR
authors.lastname: Larson
authors.forename: Mary Beth
authors.initials: MB
authors.lastname: Humphrey
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Madden
authors.forename: A Cuneyt
authors.initials: AC
authors.lastname: Tas
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000737:chemistry; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D006878:Hydroxides / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry / Q000648:ultrastructure; D017680:Potassium Compounds / Q000737:chemistry*; D012972:Sodium Hydroxide / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D013499:Surface Properties; D013696:Temperature; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology; D017155:Wettability; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D006878:Hydroxides; D017680:Potassium Compounds; D012996:Solutions; D012972:Sodium Hydroxide; C020243:calcium phosphate; D014025:Titanium; C029943:potassium hydroxide
references.citation: Biomaterials. 2004 Aug;25(19):4759-66
references.pmid: 15120522
references.citation: J Mater Sci Mater Med. 2004 Feb;15(2):99-107
references.pmid: 15330042
references.citation: J Biomed Mater Res. 1998 Jul;41(1):120-30
references.pmid: 9641632
references.citation: Acta Biomater. 2010 Jan;6(1):241-9
references.pmid: 19577668
references.citation: Biomaterials. 2011 May;32(13):3395-403
references.pmid: 21310480
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12748-53
references.pmid: 18753619
references.citation: J Biomed Mater Res. 1996 Nov;32(3):409-17
references.pmid: 8897146
references.citation: J Biomed Mater Res. 1973;7(3):25-42
references.pmid: 4123968
references.citation: Clin Oral Implants Res. 1996 Mar;7(1):27-37
references.pmid: 9002820
references.citation: Int J Artif Organs. 2009 Nov;32(11):811-20
references.pmid: 20020413
references.citation: J Biomed Mater Res. 1991 Jan;25(1):53-65
references.pmid: 1850430
references.citation: Acta Biomater. 2010 Sep;6(9):3362-78
references.pmid: 20167295
references.citation: J Biomed Mater Res A. 2003 Oct 1;67(1):26-35
references.pmid: 14517858
references.citation: Unfallchirurg. 2003 Aug;106(8):618-24
references.pmid: 12955232
references.citation: J Appl Biomater. 1993 Winter;4(4):317-29
references.pmid: 10172006
references.citation: ACS Appl Mater Interfaces. 2009 Oct;1(10):2312-9
references.pmid: 20355867
references.citation: Clin Oral Implants Res. 2006 Jun;17(3):258-64
references.pmid: 16672020
references.citation: J Lab Clin Med. 2001 Apr;137(4):296-302
references.pmid: 11283525
references.citation: J Mater Sci Mater Med. 2008 Jan;19(1):369-75
references.pmid: 17607514
references.citation: J Mater Sci Mater Med. 2011 Feb;22(2):273-8
references.pmid: 21188481
references.citation: Clin Oral Implants Res. 2010 Jun;21(6):642-9
references.pmid: 20666791
references.citation: J Biomed Mater Res A. 2003 Jul 1;66(1):138-45
references.pmid: 12833440
references.citation: J Biomed Mater Res. 2002 Sep 5;61(3):399-407
references.pmid: 12115465
references.citation: J Biomed Mater Res. 1999 May;45(2):100-7
references.pmid: 10397963
references.citation: J Bone Miner Metab. 2004;22(4):310-7
references.pmid: 15221488
references.citation: Acta Crystallogr B. 2002 Aug;58(Pt 4):587-93
references.pmid: 12149547
references.citation: J Mater Sci Mater Med. 2010 Sep;21(9):2511-21
references.pmid: 20549311
references.citation: Biomaterials. 1998 Sep;19(18):1621-39
references.pmid: 9839998
references.citation: J Biomed Mater Res. 2001 Sep 15;56(4):562-70
references.pmid: 11400134
references.citation: Acta Biomater. 2010 Jun;6(6):2314-21
references.pmid: 19963080
references.citation: J Biomed Mater Res. 2002;63(5):522-30
references.pmid: 12209896
references.citation: Colloids Surf B Biointerfaces. 2008 Mar 15;62(1):1-4
references.pmid: 18207376
references.citation: Nanotechnology. 2008 Jul 9;19(27):275604
references.pmid: 21828711
references.citation: J Biomed Mater Res. 1987 Dec;21(12):1375-81
references.pmid: 3429472
references.citation: Dent Mater. 2010 Nov;26(11):1043-51
references.pmid: 20728208
references.citation: Acta Biomater. 2012 Jul;8(7):2456-65
references.pmid: 22440242
references.citation: J Mater Sci Mater Med. 2011 Aug;22(8):1803-12
references.pmid: 21670996
references.citation: Acta Biomater. 2011 Jun;7(6):2623-30
references.pmid: 21345388
references.citation: J Biomed Mater Res. 1995 Mar;29(3):389-401
references.pmid: 7542245
references.citation: Langmuir. 2004 Aug 31;20(18):7659-64
references.pmid: 15323516
references.citation: Biomaterials. 1990 May;11(4):244-54
references.pmid: 2383619
references.citation: Acta Biomater. 2009 Jul;5(6):2322-30
references.pmid: 19332383
references.citation: Arch Orthop Trauma Surg. 2009 Jul;129(7):979-88
references.pmid: 18677495
references.citation: Biomaterials. 2010 Apr;31(10):2728-35
references.pmid: 20053436
references.citation: Biomaterials. 2010 Mar;31(7):1493-501
references.pmid: 19954836
references.citation: Clin Oral Implants Res. 2011 Jan;22(1):38-46
references.pmid: 21039892
references.citation: Langmuir. 2011 Jul 5;27(13):8171-6
references.pmid: 21644550
references.citation: J Arthroplasty. 2004 Dec;19(8 Suppl 3):94-101
references.pmid: 15578561