title: Association between the XRCC3 T241M polymorphism and risk of cancer: evidence from 157 case-control studies.
abstract: The T241M polymorphism in the X-ray cross-complementing group 3 (XRCC3) had been implicated in cancer susceptibility. The previous published data on the association between XRCC3 T241M polymorphism and cancer risk remained controversial. Hence, we performed a meta-analysis to investigate the association between cancer susceptibility and XRCC3 T241M (61,861 cases and 84,584 controls from 157 studies) polymorphism in different inheritance models. We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, significantly increased cancer risk was observed in any genetic model (dominant model: odds ration [OR]=1.07, 95% confidence interval [CI]=1.00-1.13; recessive model: OR=1.15, 95% CI=1.08-1.23; additive model: OR=1.17, 95% CI=1.08-1.28) when all eligible studies were pooled into the meta-analysis. In further stratified and sensitivity analyses, the elevated risk remained for subgroups of bladder cancer and breast cancer, especially in Caucasians. In addition, significantly decreased lung cancer risk was also observed. In summary, this meta-analysis suggests the participation of XRCC3 T241M in the susceptibility for bladder cancer and breast cancer, especially in Caucasians, and XRCC3 T241M polymorphism is associated with decreased lung cancer risk. Moreover, our work also points out the importance of new studies for T241M association in some cancer types, such as gastric cancer, colorectal cancer, and melanoma skin cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the XRCC3 polymorphism in cancer development.
authors.affiliation: Department of Research, Peace Hospital of Changzhi Medical College, Changzhi, 046000, PR China. 393120823@qq.com
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: He
authors.forename: Wu
authors.initials: W
authors.lastname: Wei
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Li
authors.forename: Xu-Liang
authors.initials: XL
authors.lastname: Shen
authors.forename: Da-peng
authors.initials: DP
authors.lastname: Ding
authors.forename: Su-Lan
authors.initials: SL
authors.lastname: Wang
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Liu
authors.forename: Jiang-Bo
authors.initials: JB
authors.lastname: Qin
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Wu
authors.forename: Dao-Lin
authors.initials: DL
authors.lastname: Xie
mesh_terms: D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D004268:DNA-Binding Proteins / Q000235:genetics*; D030541:Databases, Genetic; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005843:Geography; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000208:ethnology / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3