title: Lipoprotein (a)--lipid profile and apolipoprotein B in children of young parents with coronary artery disease.
abstract: OBJECTIVE
  To evaluate lipoprotein(a), apolipoprotein B and lipid profile in children of young parents with coronary artery disease.
  
  
  METHODS
  Analytical observational study.
  
  
  METHODS
  Tertiary care hospital.
  
  
  METHODS
  The study included 80 children (9-18 years) out of which 40 were children of young parents (one or both) with established coronary artery disease (CAD), while the other 40 were children of parents with no evidence of CAD (controls). All were evaluated for fasting blood glucose, lipid profile, apolipoprotein B and lipoprotein (a) - Lp(a). Two sample 't' test was applied for analysis of continuous variables between study & control group.
  
  
  RESULTS
  The study group children had significantly higher levels of total serum cholesterol (p = 0.004), LDL cholesterol (p = 0.002), lipoprotein a (p = 0.001) as compared to children of the control group. A significant difference in apolipoprotein B levels (p = 0.044) was observed in children in the adolescent age group (14-18 years). Both systolic and diastolic blood pressures were significantly higher without any significant difference being observed for weight and body mass index between the two groups.
  
  
  CONCLUSIONS
  Higher levels of pro-atherogenic factors in children with family history of premature CAD indicate that the combined effects of "nature and nurture" are responsible for development of accelerated atherosclerosis especially in Indians. Tracking of Lp(a) levels from childhood may be a better option than detecting other elements of dyslipidemia which are not fully expressed until middle age.
authors.affiliation: Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.
authors.forename: Anita
authors.initials: A
authors.lastname: Khalil
authors.forename: Amit
authors.initials: A
authors.lastname: Aggarwal
authors.forename: Sarika
authors.initials: S
authors.lastname: Arora
authors.forename: Jayashree
authors.initials: J
authors.lastname: Bhattacharya
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001055:Apolipoproteins B / Q000097:blood*; D001794:Blood Pressure; D002648:Child; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male
chemical_list: D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D002784:Cholesterol