title: Increased mean platelet volume in hypertrophic cardiomyopathy.
abstract: Thromboembolic events may be seen in patients with hypertrophic cardiomyopathy (HCM). We investigated the mean platelet volume (MPV), an indicator of platelet activation in patients with HCM. This study included 112 patients with HCM, in which 40 were patients with hypertrophic obstructive cardiomyopathy (HOCM), and 106 were control participants. The MPV was significantly higher in patients with HCM than in controls (9.1 ± 0.3 vs 7.9 ± 0.3 fL, P = .01). In the subgroup analyses, MPV was also higher in patients with HOCM compared to those with hypertrophic nonobstructive cardiomyopathy (HNCM; 9.3 ± 0.3 vs 9.0 ± 0.2 fL, P = .01). Similarly, patients with HNCM had higher MPV values than controls (9.0 ± 0.2 vs 7.9 ± 0.3 fL, P = .01). The MPV was significantly and positively correlated with left ventricular outflow tract (LVOT) obstruction (r = .42, P = .001) and septal thickness (r =.62, P = .001). In linear regression analysis, MPV was independently associated only with septal thickness (β = .07, 95% confidence interval: 0.04-0.09, P = .001). The MPV can be elevated in patients with HCM regardless of the obstruction of LVOT and may be associated with the severity of septal thickness.
authors.affiliation: 1Department of Cardiology, Ahi Evran University Education and Research Hospital, Kirsehir, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Icli
authors.forename: Fatih
authors.initials: F
authors.lastname: Aksoy
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dogan
authors.forename: Akif
authors.initials: A
authors.lastname: Arslan
authors.forename: Salaheddin
authors.initials: S
authors.lastname: Akcay
authors.forename: Habil
authors.initials: H
authors.lastname: Yücel
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ersoy
authors.forename: Ozkan
authors.initials: O
authors.lastname: Gorgulu
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006346:Heart Septum / Q000000981:diagnostic imaging; D006801:Humans; D016014:Linear Models; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015999:Multivariate Analysis; D015539:Platelet Activation; D011237:Predictive Value of Tests; D012307:Risk Factors; D014463:Ultrasonography; D014694:Ventricular Outflow Obstruction / Q000097:blood / Q000209:etiology
keywords: hypertrophic cardiomyopathy; mean platelet volume; platelet activation