title: Beneficial effects of the RESMENA dietary pattern on oxidative stress in patients suffering from metabolic syndrome with hyperglycemia are associated to dietary TAC and fruit consumption.
abstract: Hyperglycemia and oxidative stress are conditions directly related to the metabolic syndrome (MetS), whose prevalence is increasing worldwide. This study aimed to evaluate the effectiveness of a new weight-loss dietary pattern on improving the oxidative stress status on patients suffering MetS with hyperglycemia. Seventy-nine volunteers were randomly assigned to two low-calorie diets (-30% Energy): the control diet based on the American Health Association criteria and the RESMENA diet based on a different macronutrient distribution (30% proteins, 30% lipids, 40% carbohydrates), which was characterized by an increase of the meal frequency (seven-times/day), low glycemic load, high antioxidant capacity (TAC) and high n-3 fatty acids content. Dietary records, anthropometrical measurements, biochemical parameters and oxidative stress biomarkers were analyzed before and after the six-month-long study. The RESMENA (Metabolic Syndrome Reduction in Navarra) diet specifically reduced the android fat mass and demonstrated more effectiveness on improving general oxidative stress through a greater decrease of oxidized LDL (oxLDL) values and protection against arylesterase depletion. Interestingly, oxLDL values were associated with dietary TAC and fruit consumption and with changes on body mass index (BMI), waist circumference, fat mass and triacilglyceride (TG) levels. In conclusion, the antioxidant properties of the RESMENA diet provide further benefits to those attributable to weight loss on patients suffering Mets with hyperglycemia.
authors.affiliation: Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona 31008, Spain. jalfmtz@unav.es.
authors.forename: Rocio
authors.initials: R
authors.lastname: de la Iglesia
authors.forename: Patricia
authors.initials: P
authors.lastname: Lopez-Legarrea
authors.forename: Paloma
authors.initials: P
authors.lastname: Celada
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Sánchez-Muniz
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martinez
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Zulet
mesh_terms: D050154:Adiposity; D000328:Adult; D000886:Anthropometry; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001794:Blood Pressure; D001823:Body Composition; D004032:Diet; D005247:Feeding Behavior; D005638:Fruit; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000178:diet therapy* / Q000473:pathology / Q000503:physiopathology; D008077:Lipoproteins, LDL / Q000378:metabolism; D024821:Metabolic Syndrome / Q000150:complications / Q000178:diet therapy* / Q000473:pathology* / Q000503:physiopathology; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein
references.citation: Diabetes Care. 2001 Apr;24(4):683-9
references.pmid: 11315831
references.citation: Obesity (Silver Spring). 2008 Jun;16(6):1355-62
references.pmid: 18421281
references.citation: Int J Surg. 2012;10(1):28-55
references.pmid: 22036893
references.citation: Br J Nutr. 2012 Jun;107 Suppl 2:S185-94
references.pmid: 22591892
references.citation: Ann Intern Med. 2009 May 5;150(9):604-12
references.pmid: 19414839
references.citation: Curr Opin Pharmacol. 2009 Dec;9(6):771-9
references.pmid: 19766058
references.citation: Expert Rev Cardiovasc Ther. 2012 Jul;10(7):933-9
references.pmid: 22908926
references.citation: Prev Med. 2007 Apr;44(4):328-34
references.pmid: 17239432
references.citation: Circulation. 2005 Oct 25;112(17):2735-52
references.pmid: 16157765
references.citation: Int J Mol Sci. 2012 Oct 22;13(10):13680-90
references.pmid: 23202973
references.citation: Int Heart J. 2011;52(6):343-7
references.pmid: 22188706
references.citation: Circ Cardiovasc Imaging. 2012 May 1;5(3):367-75
references.pmid: 22492484
references.citation: BMC Med. 2011 May 05;9:48
references.pmid: 21542944
references.citation: J Am Diet Assoc. 2010 Apr;110(4):633-8
references.pmid: 20338292
references.citation: Int J Obes (Lond). 2007 Feb;31(2):245-53
references.pmid: 16801927
references.citation: Inflammation. 2011 Jun;34(3):161-70
references.pmid: 20467889
references.citation: Lancet. 2008 Jul 19;372(9634):224-33
references.pmid: 18640459
references.citation: Arch Iran Med. 2012 Sep;15(9):549-52
references.pmid: 22924372
references.citation: Nutr Metab Cardiovasc Dis. 2013 Oct;23(10):1002-9
references.pmid: 22901841
references.citation: Biofactors. 2010 May-Jun;36(3):159-68
references.pmid: 20232344
references.citation: Rev Esp Cardiol. 2005 Dec;58(12):1371-6
references.pmid: 16371194
references.citation: Ann Hepatol. 2011 Oct-Dec;10(4):486-92
references.pmid: 21911890
references.citation: Eur J Prev Cardiol. 2014 Aug;21(8):941-8
references.pmid: 23382541
references.citation: Int J Mol Sci. 2011;12(5):3117-32
references.pmid: 21686173
references.citation: Semin Nephrol. 2011 Sep;31(5):394-9
references.pmid: 22000645
references.citation: J Physiol Biochem. 2009 Jun;65(2):165-74
references.pmid: 19886395
references.citation: J Agric Food Chem. 2008 Sep 24;56(18):8704-13
references.pmid: 18759451
references.citation: Lancet. 2005 Sep 24-30;366(9491):1059-62
references.pmid: 16182882
references.citation: J Clin Endocrinol Metab. 2012 Oct;97(10):E1844-50
references.pmid: 22872691
references.citation: J Biol Chem. 2013 Mar 1;288(9):6386-96
references.pmid: 23322769
references.citation: Diabetes Obes Metab. 2012 Feb;14(2):139-48
references.pmid: 21923735
references.citation: Nutr J. 2010 Jan 22;9:3
references.pmid: 20096093
references.citation: Nutr Metab (Lond). 2012 Jul 31;9(1):70
references.pmid: 22849424
references.citation: Am J Cardiol. 2010 Sep 15;106(6):757-63
references.pmid: 20816113
references.citation: An Sist Sanit Navar. 2008 Sep-Dec;31(3):259-80
references.pmid: 19165292
references.citation: BMC Endocr Disord. 2013 Jan 07;13:2
references.pmid: 23289895
references.citation: J Nutr. 2007 Jul;137(7):1783-8
references.pmid: 17585031
references.citation: J Ren Nutr. 2013 Jul;23(4):271-6
references.pmid: 23131574
references.citation: J Nutr. 2011 Aug;141(8):1502-7
references.pmid: 21653574
references.citation: Nutr Hosp. 2012 Jan-Feb;27(1):31-45
references.pmid: 22566302
references.citation: J Physiol Biochem. 2008 Sep;64(3):211-9
references.pmid: 19244935
references.citation: Clin Chem. 1972 Jun;18(6):499-502
references.pmid: 4337382
references.citation: Int J Mol Sci. 2011;12(9):6146-63
references.pmid: 22016650
references.citation: Public Health. 2013 Mar;127(3):241-6
references.pmid: 23290534
references.citation: Nutr Hosp. 2011 Jan-Feb;26(1):16-26
references.pmid: 21519726
references.citation: Clin Lab. 2012;58(9-10):973-8
references.pmid: 23163113
references.citation: Clin Exp Hypertens. 2004 Oct-Nov;26(7-8):747-52
references.pmid: 15702630
references.citation: Am J Clin Nutr. 2013 Feb;97(2):276-85
references.pmid: 23255569
references.citation: Curr Atheroscler Rep. 2007 Dec;9(6):472-8
references.pmid: 18377787
references.citation: Ann Nutr Metab. 2010;56(4):294-301
references.pmid: 20453498
references.citation: Biochem Med (Zagreb). 2012;22(1):63-75
references.pmid: 22384520
references.citation: Nutrition. 2010 May;26(5):534-41
references.pmid: 19783122
references.citation: Atherosclerosis. 2006 Sep;188(1):155-9
references.pmid: 16297389
references.citation: Nutr J. 2004 May 10;3:4
references.pmid: 15134582
references.citation: Obes Rev. 2012 Nov;13(11):1048-66
references.pmid: 22905670
references.citation: World J Diabetes. 2012 Dec 15;3(12):201-7
references.pmid: 23301122
references.citation: Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1102-11
references.pmid: 15790935
references.citation: Lipids. 2010 Aug;45(8):723-31
references.pmid: 20703822
references.citation: Nutrients. 2011 Mar;3(3):341-69
references.pmid: 22254101
references.citation: Am J Physiol Endocrinol Metab. 2007 Aug;293(2):E500-6
references.pmid: 17473052
references.citation: Int J Food Sci Nutr. 2009;60 Suppl 3:1-13
references.pmid: 18654910
references.citation: Eur J Nutr. 1999 Feb;38(1):20-7
references.pmid: 10338684
references.citation: Br J Nutr. 2012 Apr;107(8):1119-27
references.pmid: 21899800