title: Control of myogenesis by rodent SINE-containing lncRNAs.
abstract: Staufen1-mediated mRNA decay (SMD) degrades mRNAs that harbor a Staufen1-binding site (SBS) in their 3' untranslated regions (UTRs). Human SBSs can form by intermolecular base-pairing between a 3' UTR Alu element and an Alu element within a long noncoding RNA (lncRNA) called a &frac12;-sbsRNA. Since Alu elements are confined to primates, it was unclear how SMD occurs in rodents. Here we identify mouse mRNA 3' UTRs and lncRNAs that contain a B1, B2, B4, or identifier (ID) element. We show that SMD occurs in mouse cells via mRNA-lncRNA base-pairing of partially complementary elements and that mouse &frac12;-sbsRNA (m&frac12;-sbsRNA)-triggered SMD regulates C2C12 cell myogenesis. Our findings define new roles for lncRNAs as well as B and ID short interspersed elements (SINEs) in mice that undoubtedly influence many developmental and homeostatic pathways.
authors.affiliation: Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.
authors.forename: Jiashi
authors.initials: J
authors.lastname: Wang
authors.forename: Chenguang
authors.initials: C
authors.lastname: Gong
authors.forename: Lynne E
authors.initials: LE
authors.lastname: Maquat
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D020029:Base Pairing; D002460:Cell Line; D051379:Mice; D024510:Muscle Development / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D020086:Short Interspersed Nucleotide Elements / Q000235:genetics*; D015534:Trans-Activators / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C484446:Rent1 protein, mouse; C492187:Stau1 protein, mouse; D015534:Trans-Activators
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