title: Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models.
abstract: Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha and beta, with each having various isoforms and differential tissue distribution. In humans, mutations in ATP1A2 are associated with a rare form of hereditary migraines with aura known as familial hemiplegic migraine type II. Genetic studies in mice have revealed other neurological effects of Atp1a2 in mice including anxiety, fear, and learning and motor function disorders. This paper reviews the recent findings in the literature concerning Atp1a2.
authors.affiliation: Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Stephanie.Gritz@ucdenver.edu
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Gritz
authors.forename: Richard A
authors.initials: RA
authors.lastname: Radcliffe
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D020325:Migraine with Aura / Q000201:enzymology* / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics*
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase
references.citation: Hum Genet. 2009 Jul;126(1):115-32
references.pmid: 19455354
references.citation: Cephalalgia. 2006 Mar;26(3):324-8
references.pmid: 16472340
references.citation: J Med Genet. 2004 Aug;41(8):621-8
references.pmid: 15286158
references.citation: Epilepsia. 2008 Mar;49(3):500-8
references.pmid: 18028407
references.citation: J Biol Chem. 1999 Apr 30;274(18):12252-6
references.pmid: 10212192
references.citation: J Neurosci. 2004 Nov 24;24(47):10693-701
references.pmid: 15564586
references.citation: J Biol Chem. 2004 Oct 15;279(42):43692-6
references.pmid: 15308625
references.citation: PLoS Genet. 2011 Jun;7(6):e1002129
references.pmid: 21731499
references.citation: Neurotherapeutics. 2007 Apr;4(2):274-84
references.pmid: 17395138
references.citation: J Biol Chem. 1991 Sep 5;266(25):16925-30
references.pmid: 1653250
references.citation: J Cell Biol. 1996 Jun;133(6):1193-204
references.pmid: 8682858
references.citation: Hum Mutat. 2005 Oct;26(4):315-21
references.pmid: 16110494
references.citation: J Biol Chem. 2000 Jan 21;275(3):1976-86
references.pmid: 10636900
references.citation: J Biol Chem. 1988 Jul 25;263(21):10436-42
references.pmid: 2839491
references.citation: Neurogenetics. 2004 Jun;5(2):141-6
references.pmid: 15133718
references.citation: Hum Mutat. 2005 Sep;26(3):281
references.pmid: 16088919
references.citation: J Membr Biol. 1999 May 1;169(1):39-44
references.pmid: 10227850
references.citation: J Biol Chem. 2003 Feb 14;278(7):5317-24
references.pmid: 12458206
references.citation: Nat Genet. 2003 Feb;33(2):192-6
references.pmid: 12539047
references.citation: Obes Res. 2005 Oct;13(10):1661-71
references.pmid: 16286513
references.citation: J Neurosci. 1991 Feb;11(2):381-91
references.pmid: 1846906
references.citation: Mol Cell. 1999 May;3(5):555-63
references.pmid: 10360172
references.citation: J Neurosci. 2007 Jan 17;27(3):616-26
references.pmid: 17234593
references.citation: Neurology. 2005 Dec 13;65(11):1826-8
references.pmid: 16344534
references.citation: Nat Rev Neurosci. 2003 May;4(5):386-98
references.pmid: 12728266
references.citation: Neurogenetics. 2004 Sep;5(3):177-85
references.pmid: 15459825
references.citation: Cereb Cortex. 2002 May;12(5):515-25
references.pmid: 11950769
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11106-11
references.pmid: 16037212
references.citation: Neurol Sci. 2004 Oct;25 Suppl 3:S93-6
references.pmid: 15549578
references.citation: J Physiol. 2007 Oct 1;584(Pt 1):271-84
references.pmid: 17690149
references.citation: J Neurosci. 2009 Jun 24;29(25):8143-55
references.pmid: 19553454
references.citation: Nature. 2007 Dec 13;450(7172):1043-9
references.pmid: 18075585
references.citation: Annu Rev Biochem. 2002;71:511-35
references.pmid: 12045105
references.citation: Ann Neurol. 2006 Feb;59(2):310-4
references.pmid: 16437583
references.citation: Neurology. 2004 May 25;62(10):1857-61
references.pmid: 15159495
references.citation: Biochim Biophys Acta. 2005 May 15;1669(1):61-8
references.pmid: 15843000
references.citation: Eur J Hum Genet. 2006 May;14(5):555-60
references.pmid: 16538223
references.citation: Nucleic Acids Res. 1997 Sep 1;25(17):3389-402
references.pmid: 9254694
references.citation: J Biol Chem. 1994 Jun 17;269(24):16668-76
references.pmid: 8206986
references.citation: Mol Pharmacol. 2004 Feb;65(2):335-41
references.pmid: 14742675
references.citation: Ann Neurol. 2003 Sep;54(3):360-6
references.pmid: 12953268
references.citation: J Biol Chem. 2001 Aug 24;276(34):31535-41
references.pmid: 11427535
references.citation: J Neurosci. 2003 Jun 1;23(11):4667-76
references.pmid: 12805306
references.citation: J Bioenerg Biomembr. 2007 Dec;39(5-6):385-9
references.pmid: 18044013