title: Surface plasmon resonance sensing of nucleic acids: a review.
abstract: Biosensors based on surface plasmon resonance (SPR) have become a central tool for the investigation and quantification of biomolecules and their interactions. Nucleic acids (NAs) play a vital role in numerous biological processes and therefore have been one of the major groups of biomolecules targeted by the SPR biosensors. This paper discusses the advances of NA SPR biosensor technology and reviews its applications both in the research of molecular interactions involving NAs (NA-NA, NA-protein, NA-small molecule), as well as for the field of bioanalytics in the areas of food safety, medical diagnosis and environmental monitoring.
authors.affiliation: Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, Prague, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Šípová
authors.affiliation: Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, Prague, Czech Republic. Electronic address: homola@ufe.cz.
authors.forename: Jiří
authors.initials: J
authors.lastname: Homola
mesh_terms: D015374:Biosensing Techniques; D004784:Environmental Monitoring; D005504:Food Analysis; D006678:HIV / Q000235:genetics; D006801:Humans; D061925:Immobilized Nucleic Acids / Q000737:chemistry / Q000378:metabolism; D009696:Nucleic Acids / Q000032:analysis*; D020411:Oligonucleotide Array Sequence Analysis; D015345:Oligonucleotide Probes / Q000737:chemistry / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D020349:Surface Plasmon Resonance
chemical_list: D061925:Immobilized Nucleic Acids; D009696:Nucleic Acids; D015345:Oligonucleotide Probes; D011065:Poly(ADP-ribose) Polymerases