title: Copper-mediated transformation of organosilanes to nitriles with DMF and ammonium iodide.
abstract: Cyanation of aryl-, diaryldimethyl-, and styrylsilanes was developed for the first time under copper-mediated oxidative conditions using ammonium iodide and DMF as the combined source of nitrogen and carbon atom of the introduced cyano unit, respectively. The reaction was observed to proceed in a two-step process: initial conversion of organosilanes to their iodo intermediates and then cyanation. This method has a broad substrate scope with high functional group tolerance.
authors.affiliation: Center for Catalytic Hydrocarbon Functionalizations (IBS) and Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang
mesh_terms: D064751:Ammonium Compounds; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*
chemical_list: D064751:Ammonium Compounds; D009570:Nitriles; D000644:Quaternary Ammonium Compounds; D012821:Silanes; D003300:Copper; C582942:ammonium iodide