title: Uncorrected traumatic coagulopathy is associated with severe brain swelling during decompressive surgery to evacuate a supratentorial intradural mass lesion in patients with traumatic brain injury.
abstract: OBJECTIVE
  This study investigated the relationship between traumatic coagulopathy and severe brain swelling (SBS) during decompressive surgery to evacuate a supratentorial intradural mass lesion in patients with traumatic brain injury (TBI).
  
  
  METHODS
  A retrospective study was conducted in 96 patients who consecutively suffered from isolated TBI and underwent decompressive surgery to evacuate a supratentorial traumatic mass lesion by unilateral craniotomy. Their medical history, radiographic information, and surgical notes were reviewed. The relationship between traumatic coagulopathy and intraoperative SBS was evaluated.
  
  
  RESULTS
  Fifty-six patients presented with traumatic coagulopathy according to their preoperative coagulation panels. Thirty of them had the disorder corrected before surgery while the remaining patients did not. Twenty-four patients developed intraoperative SBS, and 22 (91.7%) of them were related to new or progressive formation of distal intracranial lesions during the surgery. Patients with uncorrected coagulopathy demonstrated a significantly higher risk of intraoperative SBS than those with corrected and no coagulopathy (61.5% vs 11.4%, P < 0.001). There was no significant difference in the incidence of intraoperative SBS between patients with corrected and no coagulopathy (13.3% versus 10.0%, P > 0.05). Multivariate logistic regression analysis showed that uncorrected coagulopathy was an independent risk factor and related to an 11.5-fold increased risk of intraoperative SBS.
  
  
  CONCLUSIONS
  Intraoperative SBS is not a rare event during decompressive surgery to evacuate a supratentorial intradural mass lesion in patients with TBI. Such surgery should be cautiously considered and performed given the existence of uncorrected traumatic coagulopathy, which is associated with an increased risk of intraoperative SBS.
authors.affiliation: Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University, China. trizzt@gmail.com
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Yajun
authors.initials: Y
authors.lastname: Xue
authors.forename: Xianzhen
authors.initials: X
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Meiqing
authors.initials: M
authors.lastname: Lou
mesh_terms: D000328:Adult; D001929:Brain Edema / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D001930:Brain Injuries / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D003399:Craniotomy / Q000379:methods; D019299:Decompression, Surgical / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015173:Supratentorial Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D016896:Treatment Outcome