title: A facile synthesis of strong near infrared fluorescent layered double hydroxide nanovehicles with an anticancer drug for tumor optical imaging and therapy.
abstract: In this work, a new multifunctional nanovehicle for tumor optical imaging and therapy was developed using Y2O3:Er(3+),Yb(3+) nanoparticles as near infrared fluorescent nanophosphors, and MgAl-layered double hydroxide (LDH) nanosheets as anticancer drug nanovehicles. Monodispersed Y2O3:Er(3+),Yb(3+) nanophosphors were readily synthesized by the urea assisted homogenous precipitation method. Hierarchically structured LDH nanosheets intercalated with an anticancer drug, fluorouracil (5FU), were deposited on the surface of Y2O3:Er(3+),Yb(3+)@SiO2 by a simple precipitation method followed by hydrothermal treatment. The resultant Y2O3:Er(3+),Yb(3+)@SiO2@LDH-5FU nanovehicles exhibit strong red upconversion fluorescence under the excitation of a 980 nm laser, which allows tracking of the nanovehicles after localization in cancer cells. A better anticancer efficiency was obtained over the nanovehicles than the free drug which can be attributed to their positively charged surfaces for favorable interaction with the negatively charged cell membranes. The multifunctional nanovehicles designed in this work are expected to be promising material candidates for simultaneous tumor optical imaging and therapy.
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62, Nanyang Drive, Singapore 637459.
authors.forename: Chunping
authors.initials: C
authors.lastname: Chen
authors.forename: Lee Kim
authors.initials: LK
authors.lastname: Yee
authors.forename: Hua
authors.initials: H
authors.lastname: Gong
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Xu
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism / Q000473:pathology; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004871:Erbium / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005453:Fluorescence; D005472:Fluorouracil / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D006878:Hydroxides / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D041622:Tomography, Optical / Q000379:methods; D015018:Ytterbium / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D015019:Yttrium / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000964:Antimetabolites, Antineoplastic; D004337:Drug Carriers; D006878:Hydroxides; D015019:Yttrium; D004871:Erbium; D015018:Ytterbium; D005472:Fluorouracil