title: Clinical characteristics of collagenous colitis with linear ulcerations.
abstract: BACKGROUND
  The relationship between the thickness of subepithelial collagen bands (CB) and the development of linear ulcerations (LU) in collagenous colitis (CC) remains unclear. The aim of the present study was to compare the clinical and pathological features, including the thickness of CB, in CC patients with and without LU.
  
  
  METHODS
  Twenty-five patients with CC diagnosed by pathological examination of biopsy specimens were analyzed. Eleven patients with LU (LU group) and 14 patients without LU (non-LU group) were compared.
  
  
  RESULTS
  Ten patients in the LU group and seven in the non-LU group were taking lansoprazole (P = 0.038). Seven patients in the LU group and one in the non-LU group were taking non-steroidal anti-inflammatory drugs (NSAIDs) (P = 0.004). All LU were locatedin the transverse or left colon. Patients in the LU group were older than those in the non-LU group (P = 0.015). CB were significantly thicker in the LU group than in the non-LU group (mean ± SD, 40 ± 21 μm vs 20 ± 11 μm, P = 0.004). Multivariate analysis showed that NSAIDs use (odds ratio, 19.236; 95% confidence interval, 1.341-275.869) and CB thickness (odds ratio, 0.893; 95% confidence interval, 0.804-0.999) were independently associated with the development of LU.
  
  
  CONCLUSIONS
  Use of lansoprazole and NSAIDs, thick CB, and advanced age are associated with the development of LU in CC patients.
authors.affiliation: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan.
authors.forename: Sumio
authors.initials: S
authors.lastname: Saito
authors.forename: Takehiko
authors.initials: T
authors.lastname: Tsumura
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Takeda
authors.forename: Jun
authors.initials: J
authors.lastname: Nakajima
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanesaka
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Matsuda
authors.forename: Azusa
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Henmi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hatamaru
authors.forename: Akira
authors.initials: A
authors.lastname: Sekikawa
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kita
authors.forename: Takanori
authors.initials: T
authors.lastname: Maruo
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okabe
authors.forename: Toru
authors.initials: T
authors.lastname: Kimura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Wakasa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Osaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D046729:Colitis, Collagenous / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D064747:Lansoprazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies
chemical_list: D000897:Anti-Ulcer Agents; D064747:Lansoprazole
keywords: collagen band; collagenous colitis; lansoprazole; linear ulceration; non-steroidal anti-inflammatory drug