title: Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites.
abstract: Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC50s) in the nM to μM range. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.
authors.affiliation: Departments of Biochemistry, University of Pretoria, Hatfield, South Africa.
authors.forename: Jandeli
authors.initials: J
authors.lastname: Niemand
authors.forename: Pieter
authors.initials: P
authors.lastname: Burger
authors.forename: Bianca K
authors.initials: BK
authors.lastname: Verlinden
authors.forename: Janette
authors.initials: J
authors.lastname: Reader
authors.forename: Annie M
authors.initials: AM
authors.lastname: Joubert
authors.forename: Annette
authors.initials: A
authors.lastname: Kaiser
authors.forename: Abraham I
authors.initials: AI
authors.lastname: Louw
authors.forename: Kiaran
authors.initials: K
authors.lastname: Kirk
authors.forename: Otto
authors.initials: O
authors.lastname: Phanstiel
authors.forename: Lyn-Marie
authors.initials: LM
authors.lastname: Birkholtz
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D016466:CHO Cells; D045744:Cell Line, Tumor; D003412:Cricetulus; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000469:parasitology; D021261:Parasitic Sensitivity Tests / Q000379:methods; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D011073:Polyamines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000873:Anthracenes; D000962:Antimalarials; D011073:Polyamines; C034020:anthracene
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