title: Brugada syndrome.
abstract: As a clinical entity the Brugada syndrome has existed since 1992 and has been associated with a high risk of sudden cardiac death predominately in younger males. Patients can present with symptoms (ie syncope, palpitations, aborted sudden cardiac death) and asymptomatically. Its three characteristic electrocardiographic patterns can occur both spontaneously or after provocation with sodium channel-blocking agents. Risk stratification and the need for treatment depend on the patient's symptoms, electrocardiography, family history, and electrophysiological inducibility to discern if treatment by implantable cardioverter defibrillator, the only effective treatment to date, is appropriate. This review focuses on Brugada syndrome and various aspects of the disease including proposed mechanisms, epidemiology, clinical presentations, genetics, diagnosis, risk stratification, and treatment options.
authors.affiliation: School of Medicine, Sydney, The University of Notre Dame Australia, 160 Oxford Street, Darlinghurst NSW 2010, Australia.
authors.forename: Jessica
authors.initials: J
authors.lastname: Jellins
authors.forename: Mitchell
authors.initials: M
authors.lastname: Milanovic
authors.forename: David-Joel
authors.initials: DJ
authors.lastname: Taitz
authors.forename: S H
authors.initials: SH
authors.lastname: Wan
authors.forename: P W
authors.initials: PW
authors.lastname: Yam
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D053840:Brugada Syndrome / Q000175:diagnosis / Q000235:genetics / Q000401:mortality* / Q000628:therapy*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology*; D017147:Defibrillators, Implantable; D004562:Electrocardiography / Q000379:methods; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006723:Hong Kong; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D026941:Sodium Channel Blockers; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D026941:Sodium Channel Blockers
keywords: Brugada syndrome; Channelopathies; Death, sudden, cardiac