title: The molecular biology of diffuse large B-cell lymphoma.
abstract: Diffuse large B-cell lymphoma (DLBCL) represents the most common type of malignant lymphoma. In the last few years, significant progress has been achieved in the understanding of the molecular pathogenesis of this entity. Gene expression profiling has identified three molecular DLBCL subtypes, termed germinal-center B-cell-like (GCB) DLBCL, activated B-cell-like (ABC) DLBCL, and primary mediastinal B-cell lymphoma (PMBL). In this review, we summarize our current understanding of the biology of these DLBCL subtypes with a special emphasis on novel diagnostic and therapeutic approaches.
authors.forename: Mareike
authors.initials: M
authors.lastname: Frick
authors.forename: Bernd
authors.initials: B
authors.lastname: Dörken
authors.forename: Georg
authors.initials: G
authors.lastname: Lenz
keywords: DLBCL; biology; gene expression profiling; malignant lymphoma; molecular pathogenesis
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