title: Physiology and toxicology of hormone-disrupting chemicals in higher plants.
abstract: Higher plants are exposed to natural environmental organic chemicals, associated with plant-environment interactions, and xenobiotic environmental organic chemicals, associated with anthropogenic activities. The effects of these chemicals result not only from interaction with metabolic targets, but also from interaction with the complex regulatory networks of hormone signaling. Purpose-designed plant hormone analogues thus show extensive signaling effects on gene regulation and are as such important for understanding plant hormone mechanisms and for manipulating plant growth and development. Some natural environmental chemicals also act on plants through interference with the perception and transduction of endogenous hormone signals. In a number of cases, bioactive xenobiotics, including herbicides that have been designed to affect specific metabolic targets, show extensive gene regulation effects, which are more in accordance with signaling effects than with consequences of metabolic effects. Some of these effects could be due to structural analogies with plant hormones or to interference with hormone metabolism, thus resulting in situations of hormone disruption similar to animal cell endocrine disruption by xenobiotics. These hormone-disrupting effects can be superimposed on parallel metabolic effects, thus indicating that toxicological characterisation of xenobiotics must take into consideration the whole range of signaling and metabolic effects. Hormone-disruptive signaling effects probably predominate when xenobiotic concentrations are low, as occurs in situations of residual low-level pollutions. These hormone-disruptive effects in plants may thus be of importance for understanding cryptic effects of low-dosage xenobiotics, as well as the interactive effects of mixtures of xenobiotic pollutants.
authors.affiliation: Centre National de la Recherche Scientifique, UMR 6553 ECOBIO, Université de Rennes 1, Campus de Beaulieu, bâtiment 14A, 35042 Rennes Cedex, France. Ivan.Couee@univ-rennes1.fr
authors.forename: Ivan
authors.initials: I
authors.lastname: Couée
authors.forename: Anne-Antonella
authors.initials: AA
authors.lastname: Serra
authors.forename: Fanny
authors.initials: F
authors.lastname: Ramel
authors.forename: Gwenola
authors.initials: G
authors.lastname: Gouesbet
authors.forename: Cécile
authors.initials: C
authors.lastname: Sulmon
mesh_terms: D004787:Environmental Pollution; D018506:Gene Expression Regulation, Plant; D010937:Plant Growth Regulators / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010944:Plants / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects*; D015262:Xenobiotics / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010937:Plant Growth Regulators; D015262:Xenobiotics
references.citation: J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):1-3
references.pmid: 21839836
references.citation: Planta. 2008 Dec;229(1):73-85
references.pmid: 18766372
references.citation: Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5535-40
references.pmid: 22431637
references.citation: Environ Toxicol Chem. 2010 Apr;29(4):922-8
references.pmid: 20821522
references.citation: Annu Rev Plant Biol. 2012;63:107-30
references.pmid: 22404467
references.citation: J Exp Bot. 2011 Oct;62(14):4995-5002
references.pmid: 21705390
references.citation: Biochem Biophys Res Commun. 2001 Jun 15;284(3):845-9
references.pmid: 11396979
references.citation: Pest Manag Sci. 2010 Feb;66(2):113-20
references.pmid: 19823992
references.citation: Curr Opin Chem Biol. 2007 Feb;11(1):88-98
references.pmid: 17208036
references.citation: J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):64-73
references.pmid: 21419222
references.citation: Biochem J. 2012 Jun 1;444(2):261-7
references.pmid: 22390794
references.citation: Trends Biotechnol. 2007 Aug;25(8):363-70
references.pmid: 17576017
references.citation: J Hazard Mater. 2011 May 15;189(1-2):19-26
references.pmid: 21367522
references.citation: Appl Microbiol Biotechnol. 2009 Nov;85(2):207-28
references.pmid: 19730850
references.citation: J Biol Chem. 2005 Jun 10;280(23):21867-81
references.pmid: 15824099
references.citation: J Chem Ecol. 2004 Dec;30(12):2527-42
references.pmid: 15724969
references.citation: Trends Plant Sci. 2004 Aug;9(8):406-13
references.pmid: 15296863
references.citation: Plant Signal Behav. 2009 Aug;4(8):701-12
references.pmid: 19820333
references.citation: J Biol Chem. 2011 Sep 16;286(37):32268-76
references.pmid: 21778235
references.citation: Biochim Biophys Acta. 2012 Feb;1819(2):86-96
references.pmid: 21867785
references.citation: Plant Physiol. 1975 Dec;56(6):747-51
references.pmid: 16659386
references.citation: Plant Sci. 2011 Mar;180(3):454-60
references.pmid: 21421392
references.citation: Trends Plant Sci. 2012 May;17(5):250-9
references.pmid: 22305233
references.citation: Plant Physiol. 1995 Sep;109(1):213-9
references.pmid: 7480323
references.citation: BMC Plant Biol. 2009 Mar 13;9:28
references.pmid: 19284649
references.citation: Planta. 2004 Sep;219(5):733-42
references.pmid: 15232695
references.citation: J Plant Physiol. 2007 Aug;164(8):1083-92
references.pmid: 17293001
references.citation: J Biol Chem. 1984 Dec 25;259(24):15364-8
references.pmid: 6542567
references.citation: BMC Genomics. 2007 Dec 05;8:450
references.pmid: 18053238
references.citation: Adv Exp Med Biol. 2012;739:17-31
references.pmid: 22399393
references.citation: Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7253-8
references.pmid: 21482761
references.citation: Toxicol Sci. 2007 Dec;100(2):464-73
references.pmid: 17785682
references.citation: Plant Physiol. 2010 May;153(1):3-13
references.pmid: 20237021
references.citation: J Exp Bot. 2012 Feb;63(3):1349-56
references.pmid: 22131162
references.citation: Funct Integr Genomics. 2005 Jan;5(1):4-17
references.pmid: 15309660
references.citation: Curr Opin Plant Biol. 2005 Jun;8(3):317-23
references.pmid: 15860429
references.citation: Molecules. 2012 Apr 13;17(4):4460-73
references.pmid: 22504831
references.citation: PLoS One. 2011 Mar 08;6(3):e17245
references.pmid: 21408147
references.citation: Eur J Cell Biol. 2012 Apr;91(4):246-56
references.pmid: 21561682
references.citation: Plant Mol Biol. 2010 Mar;72(4-5):545-56
references.pmid: 20043233
references.citation: BMC Plant Biol. 2010 Apr 07;10:59
references.pmid: 20377843
references.citation: FEBS Lett. 2002 Dec 18;532(3):407-10
references.pmid: 12482601
references.citation: Nature. 2002 Oct 31;419(6910):895-6
references.pmid: 12410298
references.citation: Proc R Soc Lond B Biol Sci. 1966 Aug 16;165(999):245-65
references.pmid: 4380541
references.citation: Curr Opin Chem Biol. 2003 Aug;7(4):505-10
references.pmid: 12941426
references.citation: Plant Cell. 2008 Nov;20(11):3122-35
references.pmid: 18984675
references.citation: Trends Plant Sci. 2005 Apr;10(4):187-94
references.pmid: 15817420
references.citation: Planta. 2007 Sep;226(4):839-51
references.pmid: 17497164
references.citation: Endocr Rev. 2009 Jun;30(4):293-342
references.pmid: 19502515
references.citation: Plant Cell. 2006 Dec;18(12):3670-85
references.pmid: 17172357
references.citation: Environ Sci Technol. 2013 Jan 15;47(2):843-9
references.pmid: 23252595
references.citation: Annu Rev Plant Physiol Plant Mol Biol. 2000 Jun;51:501-531
references.pmid: 15012200
references.citation: FEMS Yeast Res. 2006 Mar;6(2):230-48
references.pmid: 16487346
references.citation: Plant Physiol. 1979 Sep;64(3):387-92
references.pmid: 16660972
references.citation: Mol Genet Genomics. 2010 Apr;283(4):397-413
references.pmid: 20213187
references.citation: Annu Rev Microbiol. 2010;64:539-59
references.pmid: 20825354
references.citation: Plant Cell Environ. 2011 Nov;34(11):1970-85
references.pmid: 21726238
references.citation: Biosci Biotechnol Biochem. 2006 Jul;70(7):1731-9
references.pmid: 16819156
references.citation: Plant Cell. 2003 Oct;15(10):2320-32
references.pmid: 14508004
references.citation: J Neuroendocrinol. 2012 Jan;24(1):144-59
references.pmid: 21951193
references.citation: J Exp Bot. 2012 Jun;63(11):3999-4014
references.pmid: 22493519
references.citation: Plant J. 2001 Oct;28(2):237-43
references.pmid: 11722767