title: Ectopic lipid storage and insulin resistance: a harmful relationship.
abstract: Obesity increases the risk of metabolic diseases, including insulin resistance and type 2 diabetes, as well as cardiovascular disease. In addition to lipid accumulation in adipose tissue, obesity is associated with increased lipid storage in ectopic tissues, such as skeletal muscle and liver. Furthermore, lipid accumulation in the heart may result in cardiac dysfunction and heart failure. It has recently been demonstrated that intracellular lipid accumulation in ectopic tissues leads to pathological responses and impaired insulin signalling. Here, we will review the current understanding of how lipid storage and lipid droplet physiology affect the risk of developing metabolic diseases.
authors.affiliation: Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden. Jan.Boren@wlab.gu.se
authors.forename: J
authors.initials: J
authors.lastname: Borén
authors.forename: M-R
authors.initials: MR
authors.lastname: Taskinen
authors.forename: S-O
authors.initials: SO
authors.lastname: Olofsson
authors.forename: M
authors.initials: M
authors.lastname: Levin
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000378:metabolism*; D005234:Fatty Liver / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000378:metabolism; D007333:Insulin Resistance; D050356:Lipid Metabolism; D050155:Lipogenesis; D008074:Lipoproteins / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000378:metabolism; D015398:Signal Transduction; D051197:Toll-Like Receptor 4 / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism
chemical_list: C556354:AHSG protein, human; D002352:Carrier Proteins; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D000070778:Perilipin-1; D010750:Phosphoproteins; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D014280:Triglycerides; D060749:alpha-2-HS-Glycoprotein