title: Heterozygosity at the A625C polymorphic site of the MyD88 gene is associated with Mycobacterium bovis infection in cattle.
abstract: The study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis (odds ratio [OR] = 0.19; P = 6 × 10(-12)). The reduced risk, however, does not extend to animals with latent pulmonary tuberculosis (OR = 0.83; P = 0.40). Heterozygosity at the A625C single nucleotide polymorphism is associated with intermediate levels of tumor necrosis factor alpha, gamma interferon, and nitric oxide synthase (NOS). Accordingly, deficiency as well as overexpression of proinflammatory cytokines or NOS favor tuberculosis, while heterozygosity provides the animals with the optimal level of inflammation.
authors.affiliation: Department DiSSPAPA, University of Naples, Portici, Naples, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Capparelli
authors.forename: Francesco
authors.initials: F
authors.lastname: De Chiara
authors.forename: Nunzia
authors.initials: N
authors.lastname: Nocerino
authors.forename: Chiara
authors.initials: C
authors.lastname: Medaglia
authors.forename: Rosa
authors.initials: R
authors.lastname: Di Costanzo
authors.forename: Luigi
authors.initials: L
authors.lastname: Ramunno
authors.forename: Federico
authors.initials: F
authors.lastname: Capuano
authors.forename: Francesco
authors.initials: F
authors.lastname: Casalinuovo
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Matteo
authors.forename: Domenico
authors.initials: D
authors.lastname: Iannelli
mesh_terms: D000818:Animals; D001483:Base Sequence; D016022:Case-Control Studies; D002417:Cattle; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D007249:Inflammation / Q000235:genetics; D008969:Molecular Sequence Data; D009163:Mycobacterium bovis; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics*; D011110:Polymorphism, Genetic; D014380:Tuberculosis, Bovine / Q000235:genetics* / Q000276:immunology
chemical_list: D053594:Myeloid Differentiation Factor 88
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