title: Fertility drug use and the risk of ovarian tumors in infertile women: a case-control study.
abstract: OBJECTIVE
  To assess the influence of infertility and fertility drugs on risk of ovarian tumors.
  
  
  METHODS
  Case-control study (Mayo Clinic Ovarian Cancer Study).
  
  
  METHODS
  Ongoing academic study of ovarian cancer.
  
  
  METHODS
  A total of 1,900 women (1,028 with ovarian tumors and 872 controls, frequency matched on age and region of residence) who had provided complete information in a self-report questionnaire about history of infertility and fertility drug use.
  
  
  METHODS
  None.
  
  
  METHODS
  Effect of infertility history, use of fertility drugs and oral contraception, and gravidity on the risk of ovarian tumor development, after controlling for potential confounders.
  
  
  RESULTS
  Among women who had a history of infertility, use of fertility drugs was reported by 44 (24%) of 182 controls and 38 (17%) of 226 cases. Infertile women who used fertility drugs were not at increased risk of developing ovarian tumors compared with infertile women who did not use fertility drugs; the adjusted odds ratio was 0.64 (95% CI, 0.37, 1.11). The findings were similar when stratified by gravidity and when analyzed separately for borderline versus invasive tumors.
  
  
  CONCLUSIONS
  We found no statistically significant association between fertility drug use and risk of ovarian tumors. Further larger, prospective studies are needed to confirm this observation.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA. asante.albert@mayo.edu
authors.forename: Albert
authors.initials: A
authors.lastname: Asante
authors.forename: Phoebe H
authors.initials: PH
authors.lastname: Leonard
authors.forename: Amy L
authors.initials: AL
authors.lastname: Weaver
authors.forename: Ellen L
authors.initials: EL
authors.lastname: Goode
authors.forename: Jani R
authors.initials: JR
authors.lastname: Jensen
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stewart
authors.forename: Charles C
authors.initials: CC
authors.lastname: Coddington
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005298:Fertility; D005300:Fertility Agents, Female / Q000009:adverse effects*; D020073:Gravidity; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000188:drug therapy* / Q000503:physiopathology; D016015:Logistic Models; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D015999:Multivariate Analysis; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D011247:Pregnancy; D015995:Prevalence; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D005300:Fertility Agents, Female
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