title: Tryptophan metabolism: entering the field of aging and age-related pathologies.
abstract: Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase lifespan. Recent studies in multiple organisms have implicated tryptophan metabolism as a powerful regulator of age-related diseases and lifespan. Its high conservation throughout evolution has enabled studies that begin to dissect the contribution of individual enzymes and metabolites. Here, we focus on the emerging view of tryptophan metabolism as a pathway that integrates environmental and metabolic signals to regulate animal biology and health.
authors.affiliation: University of Groningen, University Medical Centre Groningen, European Research Institute for the Biology of Aging, 9700 AD Groningen, The Netherlands.
authors.forename: Annemieke T
authors.initials: AT
authors.lastname: van der Goot
authors.forename: Ellen A A
authors.initials: EA
authors.lastname: Nollen
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D006801:Humans; D015398:Signal Transduction; D014364:Tryptophan / Q000378:metabolism*
chemical_list: D014364:Tryptophan