title: Major changes in lung cancer over the last ten years in France: the KBP-CPHG studies.
abstract: The incidence of lung cancer has dramatically increased in ten years, being now the most commonly diagnosed cancer in males and the fourth most commonly diagnosed cancer in females. Considering social and scientific evolution, the aim of the present study conducted by the French College of General Hospital Respiratory Physicians (CPHG) was to compare patient and lung cancer characteristics at a ten-year interval. Two epidemiological studies, KBP-2000-CPHG and KBP-2010-CPHG, were conducted at a ten-year interval. These prospective multicentre studies included all patients ≥ 18 years of age with primary lung cancer diagnosed between 1st January and 31st December 2000 or 2010, and managed in the respiratory departments of one of the participating general hospitals. A standardised form was completed for each patient. A steering committee checked recruitment exhaustiveness. Respectively, in 2000 and 2010, 137 and 104 centres included 5667 and 7051 patients. Compared to 2000, patients in 2010 were significantly older (65.5 ± 11.3 vs. 64.3 ± 11.5 years, p < 0.0001), more frequently women (24.3% vs. 16.0%, p < 0.0001) and never-smokers (10.9% vs. 7.2%, p < 0.0001). In 2010, adenocarcinoma was the most common tumour (45.4%, vs. 29.0% in 2000, p < 0.0001). The adenocarcinoma rate increased irrespective of sex, age, or smoking status (relative risk [RR] before and after adjustment, RR = 2.07 [1.92-2.24], p < 0.0001 and 2.06 [1.90-2.23], p < 0.0001). In ten years, lung cancer characteristics have therefore changed: more women, more never-smokers, and more adenocarcinomas. The particular high increase in adenocarcinoma rate deserves further analysis.
authors.affiliation: Respiratory Medicine Department, General Hospital, 6-8 Rue Saint Fiacre, BP 218, 77104 Meaux CEDEX, France. ch-locher@ch-meaux.fr
authors.forename: Chrystèle
authors.initials: C
authors.lastname: Locher
authors.forename: Didier
authors.initials: D
authors.lastname: Debieuvre
authors.forename: Daniel
authors.initials: D
authors.lastname: Coëtmeur
authors.forename: François
authors.initials: F
authors.lastname: Goupil
authors.forename: Olivier
authors.initials: O
authors.lastname: Molinier
authors.forename: Thierry
authors.initials: T
authors.lastname: Collon
authors.forename: Charles
authors.initials: C
authors.lastname: Dayen
authors.forename: Jacques
authors.initials: J
authors.lastname: Le Treut
authors.forename: Bernard
authors.initials: B
authors.lastname: Asselain
authors.forename: Francis
authors.initials: F
authors.lastname: Martin
authors.forename: François
authors.initials: F
authors.lastname: Blanchon
authors.forename: Michel
authors.initials: M
authors.lastname: Grivaux
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies