title: Mortality from pulmonary heart disease in Japan, 1979-2006.
abstract: OBJECTIVE
  In Japan, there have been no reports on the time-trends of mortality rates from pulmonary heart disease without pulmonary embolism (PHD). Our aim was to examine the annual changes of mortality in Japan.
  
  
  METHODS
  Annual age-adjusted and age-specific PHD mortality for Japanese residents during 1979-2006 were calculated from "Vital statistics of Japan" and census data and population estimates for intercensal years.
  
  
  RESULTS
  The number of age-adjusted deaths from PHD continued to decrease throughout the study period. The age-specific mortality from PHD increased throughout the life span except below 1 year old and decreased in recent years. Male mortality was greater at most ages. In Poisson regression analysis, the relative risk of death from PHD was increased in males and the aged except below 1 year-age, and decreased in recent years. The annual number of deaths from idiopathic pulmonary arterial hypertension/heritable pulmonary arterial hypertension (IPAH/HPAH) continued to increase throughout the study period. The number of annual new cases with IPAH/HPAH was estimated to be about 400 in a recent period of 10 years.
  
  
  CONCLUSIONS
  The annual number of deaths from PHD decreased, and those from IPAH/HPAH increased significantly during 1979-2006 in Japan.
authors.affiliation: Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
authors.forename: Masahito
authors.initials: M
authors.lastname: Sakuma
authors.forename: Norifumi
authors.initials: N
authors.lastname: Nakanishi
authors.forename: Kunio
authors.initials: K
authors.lastname: Shirato
keywords: idiopathic pulmonary arterial hypertension; mortality; pulmonary circulation; pulmonary hypertension
references.citation: Eur Respir J. 2007 Jul;30(1):104-9
references.pmid: 17360728
references.citation: Eur Heart J. 2006 Mar;27(5):589-95
references.pmid: 16431875
references.citation: Circulation. 2002 Sep 17;106(12):1477-82
references.pmid: 12234951
references.citation: Eur J Clin Invest. 2006 Sep;36 Suppl 3:10-5
references.pmid: 16919005
references.citation: MMWR Surveill Summ. 2005 Nov 11;54(5):1-28
references.pmid: 16280974
references.citation: Am J Respir Crit Care Med. 2006 May 1;173(9):1023-30
references.pmid: 16456139
references.citation: Chest. 2001 Jun;119(6):1801-6
references.pmid: 11399707
references.citation: J Am Coll Cardiol. 2002 Aug 21;40(4):780-8
references.pmid: 12204511
references.citation: N Engl J Med. 1996 Aug 29;335(9):609-16
references.pmid: 8692238
references.citation: J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S43-S54
references.pmid: 19555858
references.citation: Intern Med. 1999 Jan;38(1):12-6
references.pmid: 10052735
references.citation: Chest. 2000 Mar;117(3):796-800
references.pmid: 10713009
references.citation: Ann Intern Med. 1987 Aug;107(2):216-23
references.pmid: 3605900
references.citation: J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):5S-12S
references.pmid: 15194173