title: Achieving cancer cell death with PI3K/mTOR-targeted therapies.
abstract: Inhibitors of the PI3K/mTOR signaling network are under development as novel cancer therapies. However, these compounds do not cause robust cytotoxic responses in tumor cells unless combined with other agents. Rational combinations with other targeted therapies will likely be necessary to achieve the potential of PI3K/mTOR inhibitors in oncology.
authors.affiliation: Department of Biochemistry, College of Medicine, Inje University, Busan 614-735, Korea.
authors.forename: Sung Su
authors.initials: SS
authors.lastname: Yea
authors.forename: David A
authors.initials: DA
authors.lastname: Fruman
mesh_terms: D017209:Apoptosis; D016923:Cell Death; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; C546842:MTOR protein, human
references.citation: Cell. 2012 Apr 13;149(2):274-93
references.pmid: 22500797
references.citation: Nat Med. 2010 Feb;16(2):205-13
references.pmid: 20072130
references.citation: Clin Cancer Res. 2012 May 1;18(9):2603-12
references.pmid: 22407832
references.citation: Leukemia. 2013 Mar;27(3):586-94
references.pmid: 23090679
references.citation: Nat Med. 2008 Dec;14(12):1351-6
references.pmid: 19029981
references.citation: Cell. 2007 Jun 29;129(7):1261-74
references.pmid: 17604717
references.citation: Cancer Discov. 2012 May;2(5):405-13
references.pmid: 22588878
references.citation: Blood. 2012 Oct 25;120(17):3501-9
references.pmid: 22955911
references.citation: Nat Rev Mol Cell Biol. 2010 May;11(5):329-41
references.pmid: 20379207
references.citation: Cancer Discov. 2011 Dec;1(7):562-72
references.pmid: 22586681