title: Bisucaberin B, a linear hydroxamate class siderophore from the marine bacterium Tenacibaculum mesophilum.
abstract: A siderophore, named bisucaberin B, was isolated from Tenacibaculum mesophilum bacteria separated from a marine sponge collected in the Republic of Palau. Using spectroscopic and chemical methods, the structure of bisucaberin B (1) was clearly determined to be a linear dimeric hydroxamate class siderophore. Although compound 1 is an open form of the known macrocyclic dimer bisucaberin (2), and was previously described as a bacterial degradation product of desferrioxamine B (4), the present report is the first description of the de novo biosynthesis of 1. To the best of our knowledge, compound 1 is the first chemically characterized siderophore isolated from a bacterium belonging to the phylum Bacteroidetes.
authors.affiliation: Creative Research Institution, Hokkaido University, Hakodate 041-8611, Japan. masakifujita@fish.hokudai.ac.jp
authors.forename: Masaki J
authors.initials: MJ
authors.lastname: Fujita
authors.forename: Koji
authors.initials: K
authors.lastname: Nakano
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Sakai
mesh_terms: D000818:Animals; D003676:Deferoxamine / Q000378:metabolism; D006877:Hydroxamic Acids / Q000737:chemistry*; D019029:Palau; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification*; D011161:Porifera / Q000382:microbiology; D012623:Seawater / Q000382:microbiology; D017262:Siderophores / Q000737:chemistry* / Q000302:isolation & purification*; D060493:Tenacibaculum / Q000378:metabolism*
chemical_list: D006877:Hydroxamic Acids; D010456:Peptides, Cyclic; D017262:Siderophores; C054842:bisucaberin; D003676:Deferoxamine
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