title: No association of primary Sjögren's syndrome with Fcγ receptor gene variants.
abstract: The genetic background of primary Sjögren's syndrome (pSS) is partly shared with systemic lupus erythematosus (SLE). Immunoglobulin G Fc receptors are important for clearance of immune complexes. Fcγ receptor variants and gene deletion have been found to confer SLE risk. In this study, four Fcγ receptor single-nucleotide polymorphisms (SNPs) and one copy number variation (CNV) were studied. Swedish and Norwegian pSS patients (N=527) and controls (N=528) were genotyped for the Fcγ receptor gene variant FCGR2A H131R (rs1801274) by the Illumina GoldenGate assay. FCGR3A F158V (rs396991) was analysed in 488 patients and 485 controls, FCGR3B rs447536 was analysed in 471 patients and 467 controls, and FCGR3B rs448740 was analysed in 478 cases and 455 controls, using TaqMan SNP genotyping assays. FCGR3B CNV was analysed in 124 patients and 139 controls using a TaqMan copy number assay. None of the SNPs showed any association with pSS. Also, no FCGR3B CNV association was detected. The lack of association of pSS with Fcγ receptor gene variants indicates that defective immune complex clearance may not be as important in pSS pathogenesis as in SLE, and may point to important differences between SLE and pSS.
authors.affiliation: Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway. kahn@helse-bergen.no
authors.forename: K
authors.initials: K
authors.lastname: Haldorsen
authors.forename: S
authors.initials: S
authors.lastname: Appel
authors.forename: S
authors.initials: S
authors.lastname: Le Hellard
authors.forename: O
authors.initials: O
authors.lastname: Bruland
authors.forename: J G
authors.initials: JG
authors.lastname: Brun
authors.forename: R
authors.initials: R
authors.lastname: Omdal
authors.forename: G
authors.initials: G
authors.lastname: Kristjansdottir
authors.forename: E
authors.initials: E
authors.lastname: Theander
authors.forename: C P D
authors.initials: CP
authors.lastname: Fernandes
authors.forename: M
authors.initials: M
authors.lastname: Kvarnström
authors.forename: P
authors.initials: P
authors.lastname: Eriksson
authors.forename: L
authors.initials: L
authors.lastname: Rönnblom
authors.forename: M W
authors.initials: MW
authors.lastname: Herlenius
authors.forename: G
authors.initials: G
authors.lastname: Nordmark
authors.forename: R
authors.initials: R
authors.lastname: Jonsson
authors.forename: A I
authors.initials: AI
authors.lastname: Bolstad
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D017353:Gene Deletion; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*; D012859:Sjogren's Syndrome / Q000235:genetics*; D013548:Sweden
chemical_list: D017452:Receptors, IgG