title: Prostate volume as an independent predictor of prostate cancer in men with PSA of 10-50 ng ml(-1).
abstract: Prostate volume (PV) has been shown to be associated with prostate cancer (PCa) detection rates in men with a prostate-specific antigen (PSA) in the 'grey zone' (2.0-10.0 ng ml(-1)). However, the PSA 'grey zone' in Asian men should be higher because the incidence of PCa in Asian men is relatively low. Therefore, we evaluated the association between PV and PCa detection rates in men with PSAs measuring 10-50 ng ml(-1). Men who underwent a 13-core prostatic biopsy with PV documentation participated in the study. A multivariate stepwise regression was used to evaluate whether the PV at time of prostate biopsy could predict the risk of PCa. The rates of PCa among men in different PSA ranges, stratified by PV medians (<60 and ≥60 ml), were calculated. There were 261 men included in the final analysis. PV was the strongest predictor of PCa risk (odds ratio, 0.02; P<0.001) compared to other variables. The PCa rates in men with PVs measuring <60 and ≥60 ml in the 10-19.9 ng ml(-1) PSA group were 40.6% and 15.1%, respectively, while the rates for men with PSAs measuring 20-50 ng ml(-1) were 65.1% and 26.8%. PV is an independent predictor of PCa in men with PSA measuring 10-50 ng ml(-1). In clinical practice, particularly for those countries with lower incidences of PCa, PV should be considered when counselling patients with PSAs measuring 10-50 ng ml(-1) regarding their PCa risks.
authors.affiliation: Department of Urology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Tang
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Jin
authors.forename: Matthew
authors.initials: M
authors.lastname: Uhlman
authors.forename: Yu-Rong
authors.initials: YR
authors.lastname: Lin
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Deng
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Ke-Ji
authors.initials: KJ
authors.lastname: Xie
mesh_terms: D000368:Aged; D044466:Asian People; D001706:Biopsy; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D009929:Organ Size; D011237:Predictive Value of Tests; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology*; D012189:Retrospective Studies; D018570:Risk Assessment
chemical_list: D017430:Prostate-Specific Antigen
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