title: Takotsubo cardiomyopathy in siblings.
abstract: We report the case of apical ballooning syndrome (ABS) in a female sibling. A 64-year-old woman was admitted to our hospital with sudden-onset chest pain. Cardiac enzymes were mildly elevated and an electrocardiogram showed broad ST-T changes. Emergency coronary angiography revealed no culprit lesion and left ventriculography demonstrated focal akinesis of the apical wall, which was consistent with ABS. Myocardial functional sympathetic innervations assessed using [(123)I]metaiodobenzylguanidine was severely impaired in the apical region. Her clinical symptoms and cardiac dysfunction recovered spontaneously. Just 1 year prior to our patient's cardiac event, her elder sister had the same symptoms and was also diagnosed with ABS. Both sisters were postmenopausal. The familial case of ABS is exceedingly rare, but these cases suggest a possible genetic etiology.
authors.affiliation: NTT Medical Center, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-8625, Japan, mikutomi@gmail.com.
authors.forename: Masayasu
authors.initials: M
authors.lastname: Ikutomi
authors.forename: Masao
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Masashiro
authors.initials: M
authors.lastname: Matsusita
authors.forename: Yuji
authors.initials: Y
authors.lastname: Watari
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arashi
authors.forename: Goro
authors.initials: G
authors.lastname: Endo
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Yamaguchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohnishi
mesh_terms: D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D017698:Postmenopause; D015635:Radionuclide Ventriculography; D012307:Risk Factors; D035781:Siblings; D054549:Takotsubo Cardiomyopathy / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R788-93
references.pmid: 16946083
references.citation: Int J Cardiol. 2010 Oct 29;144(3):444-5
references.pmid: 19375184
references.citation: Heart Vessels. 2013 Jan;28(1):130-3
references.pmid: 22391816
references.citation: Heart. 2004 Dec;90(12):e67
references.pmid: 15547001
references.citation: Int J Cardiol. 2010 Jul 9;142(2):120-5
references.pmid: 20051293
references.citation: Jpn Circ J. 2001 Apr;65(4):349-52
references.pmid: 11316138
references.citation: Am Heart J. 2008 Mar;155(3):408-17
references.pmid: 18294473
references.citation: J Nucl Med. 2004 Jul;45(7):1121-7
references.pmid: 15235057
references.citation: Heart Vessels. 2011 May;26(3):321-37
references.pmid: 21127886
references.citation: J Am Coll Cardiol. 2001 Jul;38(1):11-8
references.pmid: 11451258