title: Polycomb complex recruitment in pluripotent stem cells.
abstract: The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of methylated H3K27 found at target sites occupied by the PRC2 component. However, mounting evidence suggests that PRC2-independent mechanisms of PRC1 recruitment exist. Three studies describe that the histone demethylase Kdm2b binds to unmethylated CpG islands and recruits a subset of PRC1 complexes to chromatin in pluripotent stem cells.
authors.affiliation: Center of Regenerative Medicine in Barcelona, Aiguader 88, E-08003 Barcelona, Spain.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Barrero
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Izpisua Belmonte
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D018899:CpG Islands / Q000235:genetics*; D053595:Embryonic Stem Cells / Q000502:physiology*; D044783:F-Box Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D050437:Genes, Developmental; D056484:Jumonji Domain-Containing Histone Demethylases / Q000378:metabolism*; D063150:Polycomb Repressive Complex 1 / Q000378:metabolism*
chemical_list: D044783:F-Box Proteins; D056484:Jumonji Domain-Containing Histone Demethylases; C524747:Kdm2b protein, mouse; D063150:Polycomb Repressive Complex 1
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