title: A copper-catalyzed synthesis of 3-aroylindoles via a sp3 C-H bond activation followed by C-C and C-O bond formation.
abstract: An efficient Cu(I)-catalyzed synthesis of 3-aroylindoles has been achieved from o-alkynylated N,N-dimethylamines via a sp(3) C-H bond activation α to the nitrogen atom followed by an intramolecular nucleophilic attack with the alkyne using an aqueous solution of tert-butyl hydroperoxide (TBHP) as the oxidant. In this tandem catalytic synthesis of 3-aroylindoles both C-C and C-O bonds are installed at the expense of two sp(3) C-H bond cleavages.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Guwahati, Guwahati 781039, India.
authors.forename: Anupal
authors.initials: A
authors.lastname: Gogoi
authors.forename: Srimanta
authors.initials: S
authors.lastname: Guin
authors.forename: Saroj Kumar
authors.initials: SK
authors.lastname: Rout
authors.forename: Bhisma K
authors.initials: BK
authors.lastname: Patel