title: The beneficial role of intensive exercise on Parkinson disease progression.
abstract: In the last decade, a considerable number of articles has shown that exercise is effective in improving motor performance in Parkinson disease. In particular, recent studies have focused on the efficacy of intensive exercise in achieving optimal results in the rehabilitation of patients with Parkinson disease. The effects of intensive exercise in promoting cell proliferation and neuronal differentiation in animal models are reported in a large cohort of studies, and these neuroplastic effects are probably related to increased expression of a variety of neurotrophic factors. The authors outline the relation between intensive exercises and neuroplastic activity on animal models of Parkinson disease and discuss the clinical results of different intensive strategies on motor performance and disease progression in patients with Parkinson disease.
authors.affiliation: Department of Parkinson Disease Rehabilitation, Moriggia-Pelascini Hospital, Gravedona ed Uniti, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Frazzitta
authors.forename: Pietro
authors.initials: P
authors.lastname: Balbi
authors.forename: Roberto
authors.initials: R
authors.lastname: Maestri
authors.forename: Gabriella
authors.initials: G
authors.lastname: Bertotti
authors.forename: Natalia
authors.initials: N
authors.lastname: Boveri
authors.forename: Gianni
authors.initials: G
authors.lastname: Pezzoli
mesh_terms: D000818:Animals; D015331:Cohort Studies; D004195:Disease Models, Animal; D018450:Disease Progression; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D010300:Parkinson Disease / Q000175:diagnosis / Q000534:rehabilitation*; D010805:Physical Conditioning, Animal / Q000379:methods*; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome