title: Enzyme and metabolic engineering for the production of novel biopolymers: crossover of biological and chemical processes.
abstract: The development of synthetic biology has transformed microbes into useful factories for producing valuable polymers and/or their precursors from renewable biomass. Recent progress at the interface of chemistry and biology has enabled the production of a variety of new biopolymers with properties that substantially differ from their petroleum-derived counterparts. This review touches on recent trials and achievements in the field of biopolymer synthesis, including chemo-enzymatically synthesized aliphatic polyesters, wholly biosynthesized lactate-based polyesters, polyhydroxyalkanoates and other unusual bacterially synthesized polyesters. The expanding diversities in structure and the material properties of biopolymers are key for exploring practical applications. The enzyme and metabolic engineering approaches toward this goal are discussed by shedding light on the successful case studies.
authors.affiliation: Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering, Hokkaido University, N13-W8, Kita-ku, Sapporo 060-8628, Japan.
authors.forename: Ken'ichiro
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Seiichi
authors.initials: S
authors.lastname: Taguchi
mesh_terms: D001419:Bacteria / Q000378:metabolism; D001704:Biopolymers / Q000096:biosynthesis* / Q000737:chemistry*; D004798:Enzymes / Q000235:genetics / Q000378:metabolism; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism; D006900:Hydroxylation; D019344:Lactic Acid / Q000737:chemistry / Q000378:metabolism; D060847:Metabolic Engineering / Q000379:methods*; D011091:Polyesters / Q000737:chemistry / Q000378:metabolism; D054813:Polyhydroxyalkanoates / Q000096:biosynthesis / Q000737:chemistry; D058105:Polymerization
chemical_list: D001704:Biopolymers; D004798:Enzymes; D005227:Fatty Acids; D011091:Polyesters; D054813:Polyhydroxyalkanoates; D019344:Lactic Acid