title: Synthesis of [5]helicenes with a substituent exclusively on the interior side of the helix by metal-catalyzed cycloisomerization.
abstract: [5]Helicenes with a substituent exclusively oriented toward the interior curvature of the helix are synthesized by metal-catalyzed cycloisomerization. In addition, novel azulene-fused helicenes have been found through cycloisomerization studies. These [5]helicenes shows a high enough configurationally stability to allow resolution by HPLC on a chiral stationary phase.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Mieko
authors.initials: M
authors.lastname: Okazumi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suemune
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Usui
mesh_terms: D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D017671:Platinum Compounds / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D017671:Platinum Compounds; D011083:Polycyclic Compounds; C031660:helicenes; C030173:platinum chloride