title: Unusual features in organisation of capsular polysaccharide-related genes of C. jejuni strain X.
abstract: PCR probing of the genome of Campylobacter jejuni strain X using conserved capsular polysaccharide (CPS)-related genes allowed elucidation of a complete sequence of the respective gene cluster (cps). This is the largest known Campylobacter cps cluster (38 kb excluding flanking kps regions), which includes a number of genes not detected in other Campylobacter strains. Sequence analysis suggests genetic rearrangements both within and outside the cps gene cluster, a mechanism which may be responsible for mosaic organisation of sugar transferase-related genes leading to structural variability of the capsular polysaccharide (CPS).
authors.affiliation: School of Life Sciences, Kingston University, Faculty of Science, Engineering and Computing, Penrhyn Road, Kingston-upon Thames, KT1 2EE, UK. a.karlyshev@kingston.ac.uk
authors.forename: A V
authors.initials: AV
authors.lastname: Karlyshev
authors.forename: M A
authors.initials: MA
authors.lastname: Quail
authors.forename: J
authors.initials: J
authors.lastname: Parkhill
authors.forename: B W
authors.initials: BW
authors.lastname: Wren
mesh_terms: D016667:Bacterial Capsules / Q000235:genetics*; D016123:Campylobacter jejuni / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial; D005810:Multigene Family; D011134:Polysaccharides / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods
chemical_list: D004269:DNA, Bacterial; D011134:Polysaccharides