title: Evaluation of the antimicrobial activities of chlorhexidine gluconate, sodium hypochlorite and octenidine hydrochloride in vitro.
abstract: The objective of this study was to compare the antimicrobial activity of sodium hypochlorite (NaOCl), chlorhexidine gluconate (CHX) and octenidine hydrochloride (OCT) in different concentrations against endodontic pathogens in vitro. Agar diffusion procedure was used to determine the antimicrobial activity of the tested materials. Enterococcus faecalis, Candida albicans and the mixture of these were used for this study. In the agar diffusion test, 5.25% NaOCl exhibited better antimicrobial effect than the other concentrations of NaOCl for all strains. All concentrations of OCT were effective against C. albicans and E. faecalis. Some 0.2% CHX was ineffective on all microorganisms. Antibacterial effectiveness of all experimental solutions decreased on the mixture of all strains. Decreasing concentrations of NaOCl resulted in significantly reduced antimicrobial effect.
authors.affiliation: Department of Pediatric Dentistry, Faculty of Dentistry, University of Baskent, Ankara, Turkey. ebru_aktepe@hotmail.com
authors.forename: Resmiye E
authors.initials: RE
authors.lastname: Tirali
authors.forename: Haluk
authors.initials: H
authors.lastname: Bodur
authors.forename: Bilge
authors.initials: B
authors.lastname: Sipahi
authors.forename: Elif
authors.initials: E
authors.lastname: Sungurtekin
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D006801:Humans; D007097:Imines; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D012388:Root Canal Irrigants / Q000008:administration & dosage / Q000494:pharmacology*; D012973:Sodium Hypochlorite / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; D012388:Root Canal Irrigants; D012973:Sodium Hypochlorite; C010882:chlorhexidine gluconate; C034213:octenidine; D002710:Chlorhexidine