title: [Electrocardiographic predictors of response to cardiac resynchronization therapy of heart failure in patients with dilated cardiomyopathy].
abstract: The aim of our study was to identify electrocardiographic predictors of response to cardiac resynchronization therapy (CRT) in patients with dilated cardiomyopathy (DCM).
  
  
  METHODS
  46 patients with DCM (76% men; mean age 48.8+/-12 years; mean NYHA class 3.09+/-0.3; mean QRS duration 167+/-30.1 ms; left ventricular ejection fraction 23.5+/-6%) had CRT implanted. Assessment of clinical, laboratory and echocardiographic (including TDI) and 12-lead surface ECG parameters was performed at baseline, in 24 hours post CRT implantation and after 6 months of follow-up. Multivariate logistic regression analysis selected the following independent predictors of response to CRT: two pre-implantation - baseline RS width in lead V1 ≥ 113.5 ms (OR 0.94, 95% CI 0.814-1.00; p=0.000), BNP ≤ 456 g/ml (OR 0.92, 95% CI 0.797-1.00; p=0.001); and two post-implantation: shortening of QRS width - ΔQRS ≥ -24.5 ms (OR 0.80, 95% CI 0.586-1.00; p=0.01) and shortening of RS V1 width - ΔRSV1 ≥ -21.8 ms (S: 0.87, 95% CI 0.72-1.00; p= 0.002) in 24 hours after CRT.
authors.forename: T G
authors.initials: TG
authors.lastname: Vaĭkhanskaia
authors.forename: T V
authors.initials: TV
authors.lastname: Kurushko
authors.forename: I V
authors.initials: IV
authors.lastname: Sidorenko
authors.forename: T M
authors.initials: TM
authors.lastname: Koptiukh
authors.forename: L M
authors.initials: LM
authors.lastname: Gul'
authors.forename: O P
authors.initials: OP
authors.lastname: Mel'nikova
authors.forename: V F
authors.initials: VF
authors.lastname: Golenishcha
authors.forename: O N
authors.initials: ON
authors.lastname: Kovalenko
mesh_terms: D000328:Adult; D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D058409:Cardiac Resynchronization Therapy Devices; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D017147:Defibrillators, Implantable; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D017063:Outcome Assessment, Health Care / Q000379:methods; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D013318:Stroke Volume