title: Indirect magnetic resonance lymphography of the head and neck of dogs using Gadofluorine M and a conventional gadolinium contrast agent: a pilot study.
abstract: The purpose of this pilot study was to evaluate lymph node enhancement with an indirect magnetic resonance (MR) lymphography technique using 2 different contrast agents in the head and neck region of healthy dogs. Five dogs were imaged at various times after intradermal injection of gadoversetamide and Gadofluorine M (minimum of 1 week apart) in the right and left mandibular, temporal, and lateral neck regions. We observed consistent progressive enhancement with time in the mandibular, retropharyngeal, and superficial cervical lymph nodes. The node enhancement was comparable for both contrast agents. Contrast enhancement of the parotid lymph nodes was not seen. We conclude that this technique of indirect MR lymphography using either agent could be used to identify those lymph nodes at highest risk of metastatic disease in dogs with cancer, and to guide staging and treatment.
authors.affiliation: Department of Small Animal Clinical Sciences, 52 Campus Drive, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada. monique.mayer@usask.ca
authors.forename: Monique N
authors.initials: MN
authors.lastname: Mayer
authors.forename: Susan L
authors.initials: SL
authors.lastname: Kraft
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Bucy
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Waldner
authors.forename: Kirsten M
authors.initials: KM
authors.lastname: Elliot
authors.forename: Sheldon
authors.initials: S
authors.lastname: Wiebe
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D004283:Dog Diseases / Q000175:diagnosis; D004285:Dogs; D005260:Female; D005466:Fluorocarbons; D005682:Gadolinium / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000662:veterinary; D008198:Lymph Nodes / Q000473:pathology*; D008220:Lymphography / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage; D010865:Pilot Projects
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; D009942:Organometallic Compounds; C517961:gadofluorine M; D005682:Gadolinium
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