title: CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection.
abstract: The strong CD8+ T-cell-mediated HIV-1-suppressive capacity found in a minority of HIV-infected patients in chronic infection is associated with spontaneous control of viremia. However, it is still unclear whether such capacities were also present earlier in the CD8+ T cells from non controller patients and then lost as a consequence of uncontrolled viral replication. We studied 50 patients with primary HIV-1-infection to determine whether strong CD8+ T-cell-mediated HIV suppression is more often observed at that time. Despite high frequencies of polyfunctional HIV-specific CD8+ T-cells and a strong CD4+ T-helper response, CD8+ T-cells from 48 patients lacked strong HIV-suppressive capacities ex vivo. This indicates that the superior HIV-suppressive capacity of CD8+ T-cells from HIV controllers is not a general characteristic of the HIV-specific CD8+ T cell response in primary HIV infection.
authors.affiliation: INSERM, U1012, Le Kremlin Bicêtre, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Lécuroux
authors.forename: Isabelle
authors.initials: I
authors.lastname: Girault
authors.forename: Antoine
authors.initials: A
authors.lastname: Chéret
authors.forename: Pierre
authors.initials: P
authors.lastname: Versmisse
authors.forename: Georges
authors.initials: G
authors.lastname: Nembot
authors.forename: Laurence
authors.initials: L
authors.lastname: Meyer
authors.forename: Christine
authors.initials: C
authors.lastname: Rouzioux
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Pancino
authors.forename: Alain
authors.initials: A
authors.lastname: Venet
authors.forename: Asier
authors.initials: A
authors.lastname: Sáez-Cirión
mesh_terms: D000208:Acute Disease; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology*; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D019562:Viral Load; D014779:Virus Replication
chemical_list: D016207:Cytokines; D007376:Interleukin-2
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