title: Mechanisms of neurogenesis in the normal and injured adult brain.
abstract: Even in the adult brain, new neurons are continuously generated from endogenous neural stem cells that reside in two restricted regions: the subventricular zone (SVZ) of the lateral ventricle and the dentate gyrus of the hippocampus. These new neurons are integrated into the mature neuronal circuitry and become involved in various functions, thereby contributing to structural and functional plasticity in the adult brain. In this review, we summarize our recent findings on the regulatory mechanisms of SVZ neurogenesis under physiological and pathological conditions in various animal models. Some of these findings were presented in the Kitazato Prize Lecture at Keio University School of Medicine in 2011.
authors.affiliation: Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Sawada
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Sawamoto
mesh_terms: D000328:Adult; D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D018891:Dentate Gyrus / Q000293:injuries / Q000502:physiology* / Q000503:physiopathology; D005786:Gene Expression Regulation; D006801:Humans; D020547:Lateral Ventricles / Q000293:injuries / Q000502:physiology* / Q000503:physiopathology; D058953:Neural Stem Cells / Q000166:cytology* / Q000378:metabolism; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism; D020127:Recovery of Function; D060449:Wnt Signaling Pathway
chemical_list: C464902:ANKRD6 protein, human; D003598:Cytoskeletal Proteins; D051880:Receptors, Notch