title: [Analysis of 2000 heart transplant, procedures at la Pitié Hospital].
abstract: Since the first procedure carried out at La Pitié Hospital, on 27 April 1968, we have performed 1918 heart transplants. We analyzed outcomes in four successive periods: initial experience from 1968 to 1981 (53 patients), using early immunosuppressive regimens; an expansion phase (839 patients) from 1982 to 1992, with the introduction of cyclosporine; a stabilisation phase (522 patients) from 1993 to 2003; and the most recent phase (504 patients) from 2004 to 2010. We focused particularly on the most recent period. National super-emergency "rules were created, and grafts from older," "borderline" donors were used. Hyperimmune recipients started to be grafted, and ECMO was frequently used during the preoperative and postoperative periods. Due to limited organ availability, we have gradually placed more and more patients on mechanical cardiac support as a bridge to transplantation. Their quality of life is improved.
authors.affiliation: Chirurgie thoracique et cardio-vasculaire - Institut de cardiologie, Hôpital Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital - 75651 Paris cedex 13. alain.pavie@psl.aphp.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Pavie
authors.forename: Eleodoro
authors.initials: E
authors.lastname: Barreda
authors.forename: Shaida
authors.initials: S
authors.lastname: Varnous
authors.forename: Akhtar
authors.initials: A
authors.lastname: Rama
authors.forename: Philippe
authors.initials: P
authors.lastname: Léger
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Levasseur
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Vaissier
authors.forename: Mojgan
authors.initials: M
authors.lastname: Laali
authors.forename: Salima
authors.initials: S
authors.lastname: Ouldammar
authors.forename: Christian
authors.initials: C
authors.lastname: Cabrol
authors.forename: Pascal
authors.initials: P
authors.lastname: Leprince
authors.forename: Iradj
authors.initials: I
authors.lastname: Gangjbakhch
mesh_terms: D000328:Adult; D002309:Cardiology / Q000639:trends; D015331:Cohort Studies; D015199:Extracorporeal Membrane Oxygenation / Q000706:statistics & numerical data; D005260:Female; D016027:Heart Transplantation / Q000379:methods* / Q000706:statistics & numerical data* / Q000639:trends; D006784:Hospitals, Teaching / Q000706:statistics & numerical data; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010297:Paris / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies
chemical_list: D007166:Immunosuppressive Agents