title: Episodes of status epilepticus in young adults: etiologic factors, subtypes, and outcomes.
abstract: The aim of this study was to evaluate the type, duration, etiology, treatment, and outcome of status epilepticus (SE) episodes, among patients aged 16-50 years. A total of 101 SE episodes in 88 young adult patients fulfilled our criteria. The mean age was 32 years. Status epilepticus episodes were most frequently observed in patients 21-30 years of age. A total of 53% of the patients were male, and 57% had pre-existing epilepsy. Seventy of the 101 episodes were convulsive SE. The most common etiology was withdrawal of or change in antiepileptic drugs (AEDs), seen in 31% of the SE episodes. This study included treatment of SE with traditional AEDs. Sixty-six episodes were treated successfully with intravenous infusion of 18-mg/kg phenytoin, and six episodes were treated with 10-mg/kg phenytoin. A total of 28% of the SE episodes remained refractory to first-line treatment, which was related to the duration of SE and mortality. The outcome was death in 14% of the patients due to underlying etiologies in the hospital.
authors.affiliation: Marmara University Hospital, Department of Neurology, Istanbul, Turkey. betulozdilek@yahoo.com
authors.forename: Betul
authors.initials: B
authors.lastname: Ozdilek
authors.forename: Ipek
authors.initials: I
authors.lastname: Midi
authors.forename: Kadriye
authors.initials: K
authors.lastname: Agan
authors.forename: Canan Aykut
authors.initials: CA
authors.lastname: Bingol
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000927:Anticonvulsants / Q000627:therapeutic use*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013226:Status Epilepticus / Q000145:classification / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000927:Anticonvulsants