title: Comparison between daily supplementation doses of 200 versus 400 IU of vitamin D in infants.
abstract: The daily supplementation of vitamin D is mandatory for infants. However, there are still conflicting opinions about the exact daily dose. Thus, we aimed to evaluate a daily supplementation dose of 200 IU is sufficient and compared the supplementation doses of 200 and 400 IU per day. One hundred and sixty-nine infants were randomly assigned to two groups (group 1, 200 IU/day; group 2, 400 IU/day) and there were 75 infants in group 1 and 64 were in group 2 with a total number of 139. The median levels of 25-hydroxyvitamin D3 were significantly increased in group 2 at the age of 4 months (group 1, 39.60 mcg/L; group 2, 56.55 mcg/L; p < 0.0001). We clearly demonstrated that at the age of 4 months, none of the infants on the group 2 had a serum level of 25-hydroxyvitamin D3 less than 30 mcg/L. However, 21.3% of the infants in group 1 had a level below 30 mcg/L. Thus, in order to avoid vitamin D deficiency and rickets, we recommend supplementation dose of vitamin D at 400 IU/day as a safe and effective dose.
authors.affiliation: Department of Pediatric Oncology, Gulhane Military Medical Academy, 06018 Etlik, Ankara, Turkey. eatasdr@gmail.com
authors.forename: Erman
authors.initials: E
authors.lastname: Atas
authors.forename: Ferhan
authors.initials: F
authors.lastname: Karademır
authors.forename: Atilla
authors.initials: A
authors.lastname: Ersen
authors.forename: Cihan
authors.initials: C
authors.lastname: Meral
authors.forename: Secil
authors.initials: S
authors.lastname: Aydınoz
authors.forename: Selami
authors.initials: S
authors.lastname: Suleymanoglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gultepe
authors.forename: İsmail
authors.initials: İ
authors.lastname: Gocmen
mesh_terms: D002112:Calcifediol / Q000008:administration & dosage* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012016:Reference Values; D012279:Rickets / Q000517:prevention & control; D014808:Vitamin D Deficiency / Q000175:diagnosis / Q000517:prevention & control*
chemical_list: D002112:Calcifediol
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