title: Morphological and molecular basis of ovarian serous carcinoma.
abstract: Serous carcinoma is the most common type of epithelial ovarian cancer. In this review, we provide a comprehensive picture of ovarian serous cancers from multiple aspects: the first part of this review summarizes the morphological, histological, and immunological signatures of ovarian serous carcinoma; subsequently, we review the history of the evolvement of different grading systems used in ovarian serous cancer; in the end, we focus on characterizing the genetics that underlie the 2-tiered pathways through which ovarian serous cancers are believed to arise: the low-grade and the high-grade pathways.
authors.affiliation: Department of Pathology, the University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Rosen
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Weiwei
authors.initials: W
authors.lastname: Shan
authors.forename: Jinsong
authors.initials: J
authors.lastname: Liu
keywords: grading; molecular genetics; morphology; ovarian carcinoma; tumorigenesis
references.citation: Am J Pathol. 2004 May;164(5):1511-8
references.pmid: 15111296
references.citation: Int J Gynecol Pathol. 2004 Jul;23(3):200-5
references.pmid: 15213595
references.citation: J Natl Cancer Inst. 2002 Sep 18;94(18):1396-406
references.pmid: 12237285
references.citation: Br J Cancer. 1995 Oct;72(4):805-12
references.pmid: 7547224
references.citation: Hematol Oncol Clin North Am. 2003 Aug;17(4):909-25, vii
references.pmid: 12959182
references.citation: Gynecol Oncol. 2004 Jan;92(1):247-51
references.pmid: 14751166
references.citation: Gynecol Oncol. 2003 Aug;90(2):378-81
references.pmid: 12893203
references.citation: Int J Gynecol Pathol. 2003 Jan;22(1):52-6
references.pmid: 12496698
references.citation: J Pathol. 2004 Jun;203(2):617-9
references.pmid: 15141374
references.citation: Clin Cancer Res. 2003 Jan;9(1):20-30
references.pmid: 12538447
references.citation: Am J Surg Pathol. 2005 Feb;29(2):218-24
references.pmid: 15644779
references.citation: Am J Med Genet. 2002 Oct 30;115(3):157-63
references.pmid: 12407696
references.citation: J Natl Cancer Inst. 2003 Apr 16;95(8):625-7
references.pmid: 12697856
references.citation: Am J Clin Pathol. 2002 Jun;117(6):944-51
references.pmid: 12047147
references.citation: Anticancer Res. 1997 Jan-Feb;17(1B):613-9
references.pmid: 9066588
references.citation: Am J Surg Pathol. 2004 Apr;28(4):496-504
references.pmid: 15087669
references.citation: J Pathol. 2004 Mar;202(3):336-40
references.pmid: 14991899
references.citation: Int J Gynecol Pathol. 1989;8(2):147-55
references.pmid: 2714932
references.citation: Int J Gynecol Pathol. 1999 Jan;18(1):42-51
references.pmid: 9891240
references.citation: Histopathology. 1998 Jan;32(1):69-80
references.pmid: 9522220
references.citation: Int J Gynecol Cancer. 1993 Mar;3(2):72-79
references.pmid: 11578325
references.citation: Int J Gynecol Cancer. 1993 Jul;3(4):226-230
references.pmid: 11578350
references.citation: Hum Mutat. 2003 Mar;21(3):285-91
references.pmid: 12619114
references.citation: Acta Obstet Gynecol Scand. 1971;50(1):1-7
references.pmid: 5558593
references.citation: Gynecol Oncol. 2003 Apr;89(1):31-6
references.pmid: 12694651
references.citation: Cancer. 1998 Mar 1;82(5):893-901
references.pmid: 9486579
references.citation: Proc Natl Acad Sci U S A. 1997 May 27;94(11):5605-10
references.pmid: 9159119
references.citation: Nature. 2002 Jun 27;417(6892):949-54
references.pmid: 12068308
references.citation: Curr Opin Obstet Gynecol. 2001 Feb;13(1):31-9
references.pmid: 11176230
references.citation: J Reprod Med. 2005 Jun;50(6):467-74
references.pmid: 16050571
references.citation: Gynecol Oncol. 1999 Apr;73(1):170-1
references.pmid: 10094903
references.citation: Cancer Res. 1995 Dec 15;55(24):6172-80
references.pmid: 8521410
references.citation: Cancer. 1997 Apr 15;79(8):1581-6
references.pmid: 9118042
references.citation: J Natl Cancer Inst. 2002 Jan 2;94(1):61-7
references.pmid: 11773283
references.citation: Int J Gynecol Pathol. 2000 Jan;19(1):7-15
references.pmid: 10638449
references.citation: Med Electron Microsc. 2004 Mar;37(1):37-44
references.pmid: 15057603
references.citation: Mod Pathol. 2005 Feb;18 Suppl 2:S19-32
references.pmid: 15761464
references.citation: J Obstet Gynaecol Res. 2001 Dec;27(6):313-8
references.pmid: 11794816
references.citation: J Natl Cancer Inst. 2003 Mar 19;95(6):484-6
references.pmid: 12644542
references.citation: Int J Gynecol Pathol. 1999 Jan;18(1):29-41
references.pmid: 9891239
references.citation: Int J Gynecol Cancer. 1995 Jul;5(4):262-268
references.pmid: 11578487
references.citation: Int J Cancer. 2006 Jan 15;118(2):257-62
references.pmid: 16231326
references.citation: Cancer. 2001 Feb 1;91(3):534-40
references.pmid: 11169935
references.citation: Gynecol Oncol. 2005 Mar;96(3):671-7
references.pmid: 15721410
references.citation: Histopathology. 2004 Feb;44(2):109-15
references.pmid: 14764054
references.citation: Am J Clin Pathol. 1999 Mar;111(3):311-6
references.pmid: 10078105
references.citation: Int J Gynecol Pathol. 2000 Oct;19(4):348-53
references.pmid: 11109164
references.citation: Gynecol Oncol. 1998 Jan;68(1):47-53
references.pmid: 9454660
references.citation: Am J Hum Genet. 1998 Mar;62(3):676-89
references.pmid: 9497246