title: Homer proteins in Ca²⁺ entry.
abstract: The Homer family of proteins consists of three adaptor proteins, Homer1, Homer2 and Homer3, each with various isoforms. Homer1 family presents an EVH1 domain, a coiled coil domain and two leucine zipper domains. Homer proteins regulate a number of Ca2+-handling proteins, including transient receptor potential channels and other Ca2+-permeable channels, ionotropic and metabotropic glutamate receptors, shank scaffolding proteins or endoplasmic reticulum Ca2+ release channels. This review article focuses on the association of Homer 1 proteins with Ca2+-handling proteins and their role on intracellular Ca2+-homeostasis.
authors.affiliation: Department of Physiology (Cellular Physiology Research Group), University of Extremadura, Cáceres, Spain.
authors.forename: Isaac
authors.initials: I
authors.lastname: Jardin
authors.forename: José J
authors.initials: JJ
authors.lastname: López
authors.forename: Alejandro
authors.initials: A
authors.lastname: Berna-Erro
authors.forename: Ginés M
authors.initials: GM
authors.lastname: Salido
authors.forename: Juan A
authors.initials: JA
authors.lastname: Rosado
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002352:Carrier Proteins / Q000502:physiology*; D056966:Excitation Contraction Coupling; D000072233:Homer Scaffolding Proteins; D006801:Humans; D017470:Receptors, Glutamate / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D002352:Carrier Proteins; C000606614:HOMER1 protein, human; C000606616:HOMER3 protein, human; D000072233:Homer Scaffolding Proteins; D017470:Receptors, Glutamate; D000252:Calcium-Transporting ATPases; D002118:Calcium
keywords: Homer; IP3R; PMCA; TRP channels