title: Biologic therapy for autoimmune diseases: an update.
abstract: Biologic therapies for rheumatologic diseases, which are targeted at molecules involved in the mechanisms of the immune system, provide an alternative to the existing treatment methods of disease-modifying anti-rheumatic drugs and other immunosuppressive medications. However, the current drawbacks of biologic therapies, including the inconvenience of intravenous administration, the high costs of these drugs, and the adverse events associated with them, prevent their wide use as first-line medications. This review provides an update of the recent literature on the new biologic therapies available. The review concentrates on nine drugs: tocilizumab, rituximab, ofatumumab, belimumab, epratuzumab, abatacept, golimumab, certolizumab, and sifalimumab, which are used as therapies for rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, systemic sclerosis, or vasculitis.
authors.affiliation: Department of Medicine C, Wolfson Medical Center, 61 Halochamim Street, POB 63, Holon, 58100 Israel.
authors.forename: Ziv
authors.initials: Z
authors.lastname: Rosman
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
authors.forename: Gisele
authors.initials: G
authors.lastname: Zandman-Goddard
mesh_terms: D001327:Autoimmune Diseases / Q000628:therapy*; D001691:Biological Therapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D007167:Immunotherapy / Q000009:adverse effects / Q000379:methods*
chemical_list: D007166:Immunosuppressive Agents
references.citation: Arthritis Res Ther. 2011;13(5):R141
references.pmid: 21884601
references.citation: Lupus. 2010 Feb;19(2):146-57
references.pmid: 19946034
references.citation: Ann Rheum Dis. 2009 Jun;68(6):805-11
references.pmid: 19015206
references.citation: Clin Rev Allergy Immunol. 2005 Dec;29(3):219-28
references.pmid: 16391397
references.citation: Lancet. 2011 Feb 26;377(9767):721-31
references.pmid: 21296403
references.citation: Discov Med. 2011 Sep;12(64):229-36
references.pmid: 21955850
references.citation: Curr Pharm Des. 2011;17(29):3166-75
references.pmid: 21864262
references.citation: Ann Rheum Dis. 2009 Jun;68(6):797-804
references.pmid: 19015207
references.citation: Ann Rheum Dis. 2011 Dec;70(12):2095-102
references.pmid: 21859692
references.citation: Clin Rev Allergy Immunol. 2012 Apr;42(2):247-55
references.pmid: 21732045
references.citation: J Am Acad Dermatol. 2012 Oct;67(4):617-22
references.pmid: 22243765
references.citation: N Engl J Med. 2010 Jul 15;363(3):221-32
references.pmid: 20647199
references.citation: J Rheumatol. 2010 Mar;37(3):558-67
references.pmid: 20110520
references.citation: Semin Arthritis Rheum. 2010 Jun;39(6):425-41
references.pmid: 20223500
references.citation: Joint Bone Spine. 2012 Jul;79(4):365-9
references.pmid: 22285615
references.citation: Arthritis Rheum. 2010 Aug;62(8):2227-38
references.pmid: 20506254
references.citation: Isr Med Assoc J. 2008 Jan;10(1):55-7
references.pmid: 18300575
references.citation: Autoimmun Rev. 2007 Mar;6(4):257-9
references.pmid: 17317619
references.citation: Ann Rheum Dis. 2011 May;70(5):755-9
references.pmid: 21187298
references.citation: Int J Rheumatol. 2012;2012:946048
references.pmid: 22315615
references.citation: Arthritis Rheum. 2009 Sep 15;61(9):1168-78
references.pmid: 19714604
references.citation: Int J Gen Med. 2010 Oct 05;3:305-11
references.pmid: 21042569
references.citation: Clin Ther. 2006 Nov;28(11):1764-78
references.pmid: 17212998
references.citation: Ther Clin Risk Manag. 2007 Oct;3(5):953-9
references.pmid: 18473018
references.citation: Ann Rheum Dis. 2011 Nov;70(11):1905-13
references.pmid: 21798883
references.citation: Arthritis Rheum. 2005 Aug;52(8):2263-71
references.pmid: 16052582
references.citation: Clin Ther. 2012 Oct;34(10):2091-103
references.pmid: 23031624
references.citation: Ann N Y Acad Sci. 2005 Jun;1051:779-86
references.pmid: 16127015
references.citation: Arthritis. 2011;2011:765624
references.pmid: 22046525
references.citation: Arthritis Rheum. 2008 Nov;58(11):3402-12
references.pmid: 18975305
references.citation: Acta Reumatol Port. 2011 Oct-Dec;36(4):385-8
references.pmid: 22472929
references.citation: Arthritis Rheum. 2009 Aug;60(8):2272-83
references.pmid: 19644849
references.citation: Lupus. 1999;8(9):705-12
references.pmid: 10602441
references.citation: Arthritis Rheum. 2010 Oct;62(10):3077-87
references.pmid: 20533545
references.citation: Int J Rheumatol. 2011;2011:214013
references.pmid: 21826145
references.citation: Ann Rheum Dis. 2011 Oct;70(10):1826-30
references.pmid: 21893583
references.citation: N Engl J Med. 2005 Sep 15;353(11):1114-23
references.pmid: 16162882
references.citation: Br J Clin Pharmacol. 2011 Feb;71(2):175-82
references.pmid: 21219397
references.citation: Autoimmun Rev. 2010 Nov;10(1):46-50
references.pmid: 20656071
references.citation: Ann Rheum Dis. 2009 Jun;68(6):789-96
references.pmid: 19066176
references.citation: Arthritis Res Ther. 2011 May 25;13 Suppl 1:S5
references.pmid: 21624184
references.citation: Semin Arthritis Rheum. 2004 Dec;34(3):593-601
references.pmid: 15609263
references.citation: Clin Rev Allergy Immunol. 2010 Apr;38(2-3):201-69
references.pmid: 19590986
references.citation: Arthritis Rheum. 2009 Jun;60(6):1785-96
references.pmid: 19479852
references.citation: Expert Rev Clin Immunol. 2007 Sep;3(5):773-80
references.pmid: 20477027
references.citation: Arthritis Rheum. 2009 Apr;60(4):976-86
references.pmid: 19333944
references.citation: BMC Med. 2010 Nov 29;8:77
references.pmid: 21114845
references.citation: Ann Rheum Dis. 2009 Oct;68(10):1580-4
references.pmid: 19019888
references.citation: Ann Rheum Dis. 2011 Dec;70(12):2119-25
references.pmid: 21859685
references.citation: J Clin Pharmacol. 2013 Feb;53(2):151-9
references.pmid: 23436260
references.citation: Ann Med. 2011 Mar;43(2):133-41
references.pmid: 21244218
references.citation: J Rheumatol. 2010 May;37(5):917-27
references.pmid: 20194448
references.citation: Biol Pharm Bull. 2008 Jun;31(6):1159-63
references.pmid: 18520048
references.citation: Arthritis Rheum. 2010 Oct;62(10):3064-76
references.pmid: 20533546
references.citation: Cochrane Database Syst Rev. 2011 Feb 16;(2):CD008794
references.pmid: 21328309
references.citation: Arthritis Rheum. 2010 Jan;62(1):222-33
references.pmid: 20039413