title: Iron metal-organic frameworks MIL-88B and NH2-MIL-88B for the loading and delivery of the gasotransmitter carbon monoxide.
abstract: Crystals of MIL-88B-Fe and NH2-MIL-88B-Fe were prepared by a new rapid microwave-assisted solvothermal method. High-purity, spindle-shaped crystals of MIL-88B-Fe with a length of about 2 μm and a diameter of 1 μm and needle-shaped crystals of NH2-MIL-88B-Fe with a length of about 1.5 μm and a diameter of 300 nm were produced with uniform size and excellent crystallinity. The possibility to reduce the as-prepared frameworks and the chemical capture of carbon monoxide in these materials was studied by in situ ultrahigh vacuum Fourier-transform infrared (UHV-FTIR) spectroscopy and Mössbauer spectroscopy. CO binding occurs to unsaturated coordination sites (CUS). The release of CO from the as-prepared materials was studied by a myoglobin assay in physiological buffer. The release of CO from crystals of MIL-88B-Fe with t(1/2) = 38 min and from crystals of NH2-MIL-88B-Fe with t(1/2) = 76 min were found to be controlled by the degradation of the MIL materials under physiological conditions. These MIL-88B-Fe and NH2-MIL-88B-Fe materials show good biocompatibility and have the potential to be used in pharmacological and therapeutic applications as carriers and delivery vehicles for the gasotransmitter carbon monoxide.
authors.affiliation: Faculty of Chemistry and Biochemistry, Inorganic Chemistry I, Ruhr-Universität Bochum, Universitätsstrasse 150, 44801 Bochum, Germany.
authors.forename: Mingyan
authors.initials: M
authors.lastname: Ma
authors.forename: Heshmat
authors.initials: H
authors.lastname: Noei
authors.forename: Bernd
authors.initials: B
authors.lastname: Mienert
authors.forename: Johanna
authors.initials: J
authors.lastname: Niesel
authors.forename: Eckhard
authors.initials: E
authors.lastname: Bill
authors.forename: Martin
authors.initials: M
authors.lastname: Muhler
authors.forename: Roland A
authors.initials: RA
authors.lastname: Fischer
authors.forename: Yuemin
authors.initials: Y
authors.lastname: Wang
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schatzschneider
authors.forename: Nils
authors.initials: N
authors.lastname: Metzler-Nolte
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008872:Microwaves; D049329:Nanostructures / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D002248:Carbon Monoxide; D007501:Iron