title: Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice.
abstract: Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activity was assessed through the levels of the IgE Ab produced in response to an allergen (OVA). The administration of C-HE prophylactically inhibited the systemic anaphylactic shock induced by compound 48/80 in mice. The oral administration of C-HE significantly reduced the total IgE levels in mice and slightly affected the production of IgG1. Furthermore, spleen cell cultures harvested from OVA-sensitised mice that had received C-HE orally showed a significant increase in Th1-derived responses (IFN-γ production). Therefore, our results suggest that the chaga mushroom extract may be used as an anti-allergic functional food.
authors.affiliation: Department of Food & Nutrition, Yuhan College, Bucheon 422-749, Republic of Korea.
authors.forename: Taek Joon
authors.initials: TJ
authors.lastname: Yoon
authors.forename: Sue Jung
authors.initials: SJ
authors.lastname: Lee
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Kim
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Cho
authors.forename: Tae Bong
authors.initials: TB
authors.lastname: Kang
authors.forename: Kwang-Won
authors.initials: KW
authors.lastname: Yu
authors.forename: Hyung Joo
authors.initials: HJ
authors.lastname: Suh
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D001487:Basidiomycota / Q000737:chemistry*; D002478:Cells, Cultured; D005260:Female; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology; D003189:p-Methoxy-N-methylphenethylamine / Q000276:immunology / Q000633:toxicity*
chemical_list: D018926:Anti-Allergic Agents; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine; D007371:Interferon-gamma; D010047:Ovalbumin