title: Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry.
abstract: BACKGROUND
  Recent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry.
  
  
  METHODS
  23 tagging SNPs in the SMAD7 gene were genotyped among 1,592 population-based and 253 clinic-based families. The SNP-colorectal cancer associations were assessed in multivariable conditional logistic regression.
  
  
  RESULTS
  Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were associated with risk of colorectal cancer. These associations were similar among the population- and the clinic-based families, though they were significant only among the former. Marginally significant differences in the SNP-colorectal cancer associations were observed by use of nonsteroidal anti-inflammatory drugs, cigarette smoking, body mass index, and history of polyps.
  
  
  CONCLUSIONS
  SMAD7 SNPs were associated with colorectal cancer risk in the Colon Cancer Family Registry. There was evidence suggesting that the association between rs12953717 and colorectal cancer risk may be modified by factors such as smoking and use of nonsteroidal anti-inflammatory drugs.
authors.affiliation: Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Jiang
authors.forename: J Esteban
authors.initials: JE
authors.lastname: Castelao
authors.forename: David
authors.initials: D
authors.lastname: Vandenberg
authors.forename: Angel
authors.initials: A
authors.lastname: Carracedo
authors.forename: Carmen M
authors.initials: CM
authors.lastname: Redondo
authors.forename: David V
authors.initials: DV
authors.lastname: Conti
authors.forename: Jesus P
authors.initials: JP
authors.lastname: Paredes Cotoré
authors.forename: John D
authors.initials: JD
authors.lastname: Potter
authors.forename: Polly A
authors.initials: PA
authors.lastname: Newcomb
authors.forename: Michael N
authors.initials: MN
authors.lastname: Passarelli
authors.forename: Mark A
authors.initials: MA
authors.lastname: Jenkins
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.forename: Steven
authors.initials: S
authors.lastname: Gallinger
authors.forename: Loic
authors.initials: L
authors.lastname: Le Marchand
authors.forename: María E
authors.initials: ME
authors.lastname: Martínez
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Ahnen
authors.forename: John A
authors.initials: JA
authors.lastname: Baron
authors.forename: Noralane M
authors.initials: NM
authors.lastname: Lindor
authors.forename: Robert W
authors.initials: RW
authors.lastname: Haile
authors.forename: Manuela
authors.initials: M
authors.lastname: Gago-Dominguez
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D015992:Body Mass Index; D016022:Case-Control Studies; D003111:Colonic Polyps / Q000150:complications / Q000473:pathology; D015179:Colorectal Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012042:Registries; D012306:Risk; D051906:Smad7 Protein / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C497806:SMAD7 protein, human; D051906:Smad7 Protein
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