title: The impact of estradiol and 1,25(OH)2D3 on metabolic syndrome in middle-aged Taiwanese males.
abstract: In addition to adipocytokines, estradiol (E2) and vitamin D have been reported to affect insulin sensitivity, glucose homeostasis and body weight. However, studies about the impact of E2 and vitamin D on metabolic syndrome (MetS) are still limited. The aim of this study is to clarify the roles of circulating E2 and vitamin D on the risk of MetS in middle-aged Taiwanese males. A total of 655 male volunteers, including 243 subjects with MetS (mean age: 56.7±5.8 years) and 412 normal controls (mean age: 55.1±3.6 years), were evaluated. Subjects with MetS had significantly lower circulating E2, 1,25(OH)2D3, and adiponectin, and higher leptin than those without MetS (P<0.001 for all comparisons). E2 and 1,25(OH)2D3 were significantly associated with 4 individual components of MetS; more than adiponectin and leptin that were only associated with 3 individual components. In multivariate regression analysis, E2 (beta = -0.216, P<0.001) and 1,25(OH)2D3 (beta = 0.067, P = 0.045) were still significant predictors of MetS independent of adiponectin and leptin. Further large studies are needed to confirm our preliminary results and elucidate the possible mechanism.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Kai-Hung
authors.initials: KH
authors.lastname: Cheng
authors.forename: Shu-Pin
authors.initials: SP
authors.lastname: Huang
authors.forename: Chun-Nung
authors.initials: CN
authors.lastname: Huang
authors.forename: Yung-Chin
authors.initials: YC
authors.lastname: Lee
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Chu
authors.forename: Chu-Fen
authors.initials: CF
authors.lastname: Chang
authors.forename: Wen-Ter
authors.initials: WT
authors.lastname: Lai
authors.forename: Chia-Chu
authors.initials: CC
authors.lastname: Liu
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D011863:Radioimmunoassay; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D052242:Adiponectin; D020738:Leptin; C118756:dihydroxy-vitamin D3; D014807:Vitamin D; D004958:Estradiol
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