title: Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future.
abstract: Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis.
authors.affiliation: Departments of Psychiatry and Neurology, College of Medicine, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Yonas E
authors.initials: YE
authors.lastname: Geda
authors.forename: Lon S
authors.initials: LS
authors.lastname: Schneider
authors.forename: Laura N
authors.initials: LN
authors.lastname: Gitlin
authors.forename: David S
authors.initials: DS
authors.lastname: Miller
authors.forename: Gwenn S
authors.initials: GS
authors.lastname: Smith
authors.forename: Joanne
authors.initials: J
authors.lastname: Bell
authors.forename: Jovier
authors.initials: J
authors.lastname: Evans
authors.forename: Michael
authors.initials: M
authors.lastname: Lee
authors.forename: Anton
authors.initials: A
authors.lastname: Porsteinsson
authors.forename: Krista L
authors.initials: KL
authors.lastname: Lanctôt
authors.forename: Paul B
authors.initials: PB
authors.lastname: Rosenberg
authors.forename: David L
authors.initials: DL
authors.lastname: Sultzer
authors.forename: Paul T
authors.initials: PT
authors.lastname: Francis
authors.forename: Henry
authors.initials: H
authors.lastname: Brodaty
authors.forename: Prasad P
authors.initials: PP
authors.lastname: Padala
authors.forename: Chiadikaobi U
authors.initials: CU
authors.lastname: Onyike
authors.forename: Luis Agüera
authors.initials: LA
authors.lastname: Ortiz
authors.forename: Sonia
authors.initials: S
authors.lastname: Ancoli-Israel
authors.forename: Donald L
authors.initials: DL
authors.lastname: Bliwise
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Martin
authors.forename: Michael V
authors.initials: MV
authors.lastname: Vitiello
authors.forename: Kristine
authors.initials: K
authors.lastname: Yaffe
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Zee
authors.forename: Nathan
authors.initials: N
authors.lastname: Herrmann
authors.forename: Robert A
authors.initials: RA
authors.lastname: Sweet
authors.forename: Clive
authors.initials: C
authors.lastname: Ballard
authors.forename: Ni A
authors.initials: NA
authors.lastname: Khin
authors.forename: Cara
authors.initials: C
authors.lastname: Alfaro
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Murray
authors.forename: Susan
authors.initials: S
authors.lastname: Schultz
authors.forename: Constantine G
authors.initials: CG
authors.lastname: Lyketsos
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology*; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis* / Q000209:etiology*
keywords: Agitation/aggression; Alzheimer's disease; Apathy; Behavioral and psychological symptoms of dementia; Delusions; Dementia; Depression; Hallucinations; Mild behavioral impairment; Mild cognitive impairment; Neuropsychiatric symptoms; Psychosis; Sleep disorders
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