title: Continuous processing and the applications of online tools in pharmaceutical product manufacture: developments and examples.
abstract: Continuous processing and production in pharmaceutical manufacturing has received increased attention in recent years mainly due to the industries' pressing needs for more efficient, cost-effective processes and production, as well as regulatory facilitation. To achieve optimum product quality, the traditional trial-and-error method for the optimization of different process and formulation parameters is expensive and time consuming. Real-time evaluation and the control of product quality using an online process analyzer in continuous processing can provide high-quality production with very high-throughput at low unit cost. This review focuses on continuous processing and the application of different real-time monitoring tools used in the pharmaceutical industry for continuous processing from powder to tablets.
authors.affiliation: Department of Pharmacy, National University of Singapore, Singapore.
authors.forename: Shing Ming
authors.initials: SM
authors.lastname: Ooi
authors.forename: Srimanta
authors.initials: S
authors.lastname: Sarkar
authors.forename: Griet
authors.initials: G
authors.lastname: van Varenbergh
authors.forename: Kris
authors.initials: K
authors.lastname: Schoeters
authors.forename: Paul Wan Sia
authors.initials: PW
authors.lastname: Heng
mesh_terms: D002626:Chemistry, Pharmaceutical; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D004867:Equipment Design; D009862:Online Systems / Q000191:economics / Q000295:instrumentation / Q000592:standards; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000191:economics / Q000592:standards; D011208:Powders; D011786:Quality Control; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000191:economics / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations; D011208:Powders; D013607:Tablets