title: Generalized eruptive histiocytoma: a rare disease in an elderly patient.
abstract: Generalized eruptive histiocytoma is considered an extremely rare subtype of non-Langerhans cells histiocytosis. In the literature, there are few reports of this disease that mainly affects adults. In this report, we present a case of generalized eruptive histiocytoma in an elderly patient who had presented symptoms for over two months. Multiple erythematous papules, asymptomatic and symmetrically distributed were observed on the trunk and limbs. Histological examination showed a dense mononuclear cell dermal infiltrate. In the immunohistochemical analysis, the cells were CD68 positive, but CD1a, S100 and CD34 negative. A diagnosis of generalized eruptive histiocytoma was established. The aim of our paper is to report a case of a very rare disease, whose subtype and affected age group are even more unusual.
authors.affiliation: General Polyclinic of Rio de Janeiro (Policlínica Geral do Rio de Janeiro - PGRJ), Rio de Janeiro, (RJ), Brazil. drafecardoso@hotmail.com
authors.forename: Fernanda
authors.initials: F
authors.lastname: Cardoso
authors.forename: Natália Battisti
authors.initials: NB
authors.lastname: Serafini
authors.forename: Brisa Dondoni
authors.initials: BD
authors.lastname: Reis
authors.forename: Mónica Daniela Gauto
authors.initials: MD
authors.lastname: Nuñez
authors.forename: José Augusto da Costa
authors.initials: JA
authors.lastname: Nery
authors.forename: Omar
authors.initials: O
authors.lastname: Lupi
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D051642:Histiocytoma / Q000473:pathology*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D035583:Rare Diseases / Q000473:pathology*; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000473:pathology*
references.citation: Actas Dermosifiliogr. 2006 Jan-Feb;97(1):35-8
references.pmid: 16540049
references.citation: J Dtsch Dermatol Ges. 2007 Feb;5(2):131-4
references.pmid: 17274780
references.citation: J Cutan Med Surg. 2009 May-Jun;13(3):146-50
references.pmid: 19426623
references.citation: Pediatr Dermatol. 2000 Nov-Dec;17(6):453-5
references.pmid: 11123777
references.citation: Arch Dermatol. 1963 Nov;88:586-96
references.pmid: 14060074
references.citation: Eur J Dermatol. 2002 Mar-Apr;12(2):205-6
references.pmid: 11872426
references.citation: Eur J Dermatol. 2006 Nov-Dec;16(6):694-5
references.pmid: 17229617
references.citation: J Coll Physicians Surg Pak. 2008 Feb;18(2):110-2
references.pmid: 18454899