title: Spontaneous ovarian hyperstimulation syndrome: case report, pathophysiological classification and diagnostic algorithm.
abstract: Spontaneous ovarian hyperstimulation syndrome is an extremely rare condition that occurs in the absence of ovarian hyperstimulation treatment. It can lead to significant morbidity and mortality, and therefore early diagnosis and supportive treatment are essential. We report an affected mother and her daughter with a previously reported heterozygous activating mutation in the FSHR gene. We performed a literature review with particular regard to pathogenesis, with a view to suggesting a pathophysiological classification system and a diagnostic algorithm to assist in the management of this rare condition.
authors.affiliation: O&G Department, Burnley General Hospital, East Lancashire Hospitals NHS Trust, Casterton Avenue, Burnley, UK. nicola.pan@yahoo.com
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Panagiotopoulou
authors.forename: Helen
authors.initials: H
authors.lastname: Byers
authors.forename: William G
authors.initials: WG
authors.lastname: Newman
authors.forename: Kalsang
authors.initials: K
authors.lastname: Bhatia
mesh_terms: D000465:Algorithms; D005260:Female; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000175:diagnosis* / Q000209:etiology* / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000209:etiology* / Q000235:genetics; D011962:Receptors, FSH / Q000235:genetics; D055815:Young Adult
chemical_list: D011962:Receptors, FSH
keywords: FSH receptor; Pathophysiological classification; Spontaneous ovarian hyperstimulation syndrome