title: Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner.
abstract: Although D1 receptor knockout mice demonstrate normal morphine place preferences, antagonism of basolateral amygdala (BLA) D1 receptors only during drug-naive rat conditioning has been reported to inhibit the expression of a morphine place preference. One possible explanation for this result is state-dependent learning. That is, the omission of the intra-BLA infusion cue during testing - which acts as a potent discriminative stimulus - may have prevented the recall of a morphine-environment association and therefore, the consequent expression of a morphine place preference. To examine this possibility, we tested whether intra-BLA infusion of the D1-receptor antagonist SCH23390 during both training and testing might reveal a morphine place preference. Our results suggest that in previously drug-naive animals, D1 receptor antagonism during testing restores the opiate conditioned place preference that is normally absent when D1 receptors are blocked only during training, suggesting that BLA D1 receptors can mediate state-dependent memory retrieval.
authors.affiliation: Institute of Medical Science, University of Toronto, Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada M5S 3E1.
authors.forename: Ryan
authors.initials: R
authors.lastname: Ting-A-Kee
authors.affiliation: Department of Molecular Genetics, Neurobiology Research Group, University of Toronto, Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada M5S 3E1.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Mercuriano
authors.affiliation: Department of Molecular Genetics, Neurobiology Research Group, University of Toronto, Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada M5S 3E1.
authors.forename: Hector
authors.initials: H
authors.lastname: Vargas-Perez
authors.affiliation: Centre for Addiction and Mental Health, Toronto, ON, Canada, M5S 2S1.
authors.forename: Susan R
authors.initials: SR
authors.lastname: George
authors.affiliation: Institute of Medical Science, University of Toronto, Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada M5S 3E1.|Department of Molecular Genetics, Neurobiology Research Group, University of Toronto, Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada M5S 3E1.
authors.forename: Derek
authors.initials: D
authors.lastname: van der Kooy
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001245:Association Learning / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D018492:Dopamine Antagonists / Q000494:pharmacology; D005260:Female; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D018345:Mice, Knockout; D009020:Morphine / Q000494:pharmacology*; D009042:Motivation / Q000187:drug effects*; D009294:Narcotics / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
chemical_list: D001552:Benzazepines; D018492:Dopamine Antagonists; D009294:Narcotics; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D009020:Morphine
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