title: Vimentin expression predicts the occurrence of metastases in non small cell lung carcinomas.
abstract: Epithelial-to-mesenchymal transition (EMT) is believed to contribute to tumour invasion. Vimentin expression by carcinoma cells is a largely recognized marker of EMT. This study aimed at examining vimentin expression in non small cell lung carcinomas (NSCLC) by immunohistochemistry to evaluate potential correlations between vimentin expression and the differentiation status, the TNM stage and the outcome of the patients. 295 NSCLC including 164 squamous cell carcinomas (SCC), 108 adenocarcinomas (AC) and 23 other NSCLC carcinomas have been examined by immunohistochemistry. Vimentin was indeed detected in 145 cases (49.2%). It was principally present in isolated tumour cells and invasive clusters, particularly in cells at the tumour/stroma interface. Vimentin expression was significantly more expressed in large cell neuroendocrine, adeno-squamous and sarcomatoid carcinomas than in SCC and AC and was significantly associated with the differentiation status of carcinomas. The follow-up of 193 patients further demonstrated that an extensive expression of vimentin (>50% of tumour cells) was associated with the occurrence of metastases. In conclusion, our data demonstrate that vimentin expression is a frequent event in NSCLC and that its expression can be associated with a lack of differentiation and the occurrence of metastases.
authors.affiliation: INSERM UMR-S 903, SFR CAP-Santé, University of Reims-Champagne-Ardenne, 51100 Reims, France.
authors.forename: Maryline
authors.initials: M
authors.lastname: Dauphin
authors.forename: Coralie
authors.initials: C
authors.lastname: Barbe
authors.forename: Sarah
authors.initials: S
authors.lastname: Lemaire
authors.forename: Béatrice
authors.initials: B
authors.lastname: Nawrocki-Raby
authors.forename: Eymeric
authors.initials: E
authors.lastname: Lagonotte
authors.forename: Gonzague
authors.initials: G
authors.lastname: Delepine
authors.forename: Philippe
authors.initials: P
authors.lastname: Birembaut
authors.forename: Christine
authors.initials: C
authors.lastname: Gilles
authors.forename: Myriam
authors.initials: M
authors.lastname: Polette
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D014746:Vimentin / Q000032:analysis / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D014746:Vimentin