title: Hepatitis C-associated cryoglobulinemic glomerulonephritis with crystalline deposits.
abstract: Infection with hepatitis C virus has been associated with a number of extrahepatic manifestations, including kidney disease. Of the glomerular pathologic states described with hepatitis C virus infection, cryoglobulinemic glomerulonephritis is the most prevalent. On kidney biopsy, cryoglobulinemic glomerulonephritis has a variable appearance, with a membranoproliferative pattern of injury as the most common light microscopic finding. Ultrastructurally, curved and paired microtubules are the most characteristic finding, but these also can be variable. We present a case of cryoglobulinemic glomerulonephritis with distinct and highly unusual ultrastructural findings.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA. mkhalighi@mednet.ucla.edu
authors.forename: Mazdak A
authors.initials: MA
authors.lastname: Khalighi
authors.forename: Charles R
authors.initials: CR
authors.lastname: Lassman
mesh_terms: D000368:Aged; D003449:Cryoglobulinemia / Q000473:pathology / Q000821:virology*; D003460:Crystallization; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology / Q000821:virology*; D006526:Hepatitis C / Q000150:complications* / Q000473:pathology; D006801:Humans
keywords: Cryoglobulinemia; cryoglobulinemic glomerulonephritis; crystalline deposits; hepatitis C; membranoproliferative glomerulonephritis; organized deposits