title: Mean platelet volume could be possible biomarker in early diagnosis and monitoring of gastric cancer.
abstract: Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related deaths worldwide. The early diagnosis of gastric cancer is fundamental in decreasing the mortality rates. It has been shown that MPV level is a sign of inflammation in hepatocellular carcinoma and pancreatic adenocarcinoma. The aim of this study is to examine whether MPV would be a useful inflammatory marker for differentiating gastric cancer patients from healthy controls. Thirty-one gastric cancer patients and 31 age-sexes matched healthy subjects included into the study. Patients with hypertension, hematological and renal disease, heart failure, chronic infection, hepatic disorder and other cancer were excluded from the study. MPV level was significantly higher in pre-operative gastric cancer patients compared to healthy subjects (8.31 fL vs. 7.85; p: 0.007). ROC analysis suggested 8.25 fL as the cut-off value for MPV (AUC: 0.717, sensitivity: 61%, specificity: 81%). Surgical tumor resection resulted in a significant decrease in MPV level (8.31 fL vs. 7.55 fL; p: 0.001). No significant difference was found in MPV level between the post-operative group and control subjects. We did not find statistically significant difference between MPV and TNM stages. In conclusion, changes in MPV values may be used as an easily available biomarker for monitoring the healthy patients for GC risk and may prompt physicians to make an early diagnosis of GC.
authors.affiliation: Department of Gastroenterology , Ankara Dışkapı Yıldırım Beyazıt Education and Research Hospital , Ankara , Turkey .
authors.forename: Serta
authors.initials: S
authors.lastname: Kılınçalp
authors.forename: Fuat
authors.initials: F
authors.lastname: Ekiz
authors.forename: Omer
authors.initials: O
authors.lastname: Başar
authors.forename: Mehmet Raşit
authors.initials: MR
authors.lastname: Ayte
authors.forename: Sahin
authors.initials: S
authors.lastname: Coban
authors.forename: Barış
authors.initials: B
authors.lastname: Yılmaz
authors.forename: Akif
authors.initials: A
authors.lastname: Altınbaş
authors.forename: Nurcan
authors.initials: N
authors.lastname: Başar
authors.forename: Bora
authors.initials: B
authors.lastname: Aktaş
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Tuna
authors.forename: Halil
authors.initials: H
authors.lastname: Erbiş
authors.forename: Engin
authors.initials: E
authors.lastname: Uçar
authors.forename: Elife
authors.initials: E
authors.lastname: Erarslan
authors.forename: Osman
authors.initials: O
authors.lastname: Yüksel
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000009:adverse effects*; D008875:Middle Aged; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality
chemical_list: D014408:Biomarkers, Tumor
keywords: Gastric cancer; gastric surgery; mean platelet volume