title: Fasting plasma glucose at 24-28 weeks to screen for gestational diabetes mellitus: new evidence from China.
abstract: OBJECTIVE
  To evaluate the usefulness of a fasting plasma glucose (FPG) at 24-28 weeks' gestation to screen for gestational diabetes mellitus (GDM).
  
  
  METHODS
  The medical records and results of a 75-g 2-h oral glucose tolerance test (OGTT) of 24,854 pregnant women without known pre-GDM attending prenatal clinics in 15 hospitals in China were examined.
  
  
  RESULTS
  FPG cutoff value of 5.1 mmol/L identified 3,149 (12.1%) pregnant women with GDM. FPG cutoff value of 4.4 mmol/L ruled out GDM in 15,369 (38.2%) women. With use of this cutoff point, 12.2% of patients with mild GDM will be missed. The positive predictive value is 0.322, and the negative predictive value is 0.928.
  
  
  CONCLUSIONS
  FPG at 24-28 weeks' gestation could be used as a screening test to identify GDM patients in low-resource regions. Women with an FPG between ≥4.4 and ≤5.0 mmol/L would require a 75-g OGTT to diagnose GDM. This would help to avoid approximately one-half (50.3%) of the formal 75-g OGTTs in China.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Zhu
authors.forename: Ling
authors.initials: L
authors.lastname: Fan
authors.forename: Hui-xia
authors.initials: HX
authors.lastname: Yang
authors.forename: Ling-ying
authors.initials: LY
authors.lastname: Kong
authors.forename: Shi-ping
authors.initials: SP
authors.lastname: Su
authors.forename: Zi-lian
authors.initials: ZL
authors.lastname: Wang
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Hu
authors.forename: Mei-hua
authors.initials: MH
authors.lastname: Zhang
authors.forename: Li-Zhou
authors.initials: LZ
authors.lastname: Sun
authors.forename: Yang
authors.initials: Y
authors.lastname: Mi
authors.forename: Xiu-ping
authors.initials: XP
authors.lastname: Du
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Yun-hui
authors.initials: YH
authors.lastname: Wang
authors.forename: Yin-ping
authors.initials: YP
authors.lastname: Huang
authors.forename: Li-ruo
authors.initials: LR
authors.lastname: Zhong
authors.forename: Hai-rong
authors.initials: HR
authors.lastname: Wu
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Yun-feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Anil
authors.initials: A
authors.lastname: Kapur
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002681:China / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000097:blood* / Q000453:epidemiology; D005215:Fasting / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D011247:Pregnancy
chemical_list: D001786:Blood Glucose
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