title: Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.
abstract: Synthesis and structure-activity relationships of 7-O-p-cyanobenzoyl pyripyropene A derivatives with modification at C1 and 11 are described. Regioselective mono-deprotection of di-tert-butylsilylene acetal was critical in their synthesis.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Tokyo 108 8641, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Ohtawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Matsuda
authors.forename: Taichi
authors.initials: T
authors.lastname: Ohshiro
authors.forename: Lawrence L
authors.initials: LL
authors.lastname: Rudel
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ōmura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Tohru
authors.initials: T
authors.lastname: Nagamitsu
mesh_terms: D002073:Butanes / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D012821:Silanes / Q000737:chemistry; D013237:Stereoisomerism; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D000097587:Sterol O-Acyltransferase 2
chemical_list: D002073:Butanes; D004791:Enzyme Inhibitors; D011725:Pyridines; D012717:Sesquiterpenes; D012821:Silanes; D002785:Sterol O-Acyltransferase; D000097587:Sterol O-Acyltransferase 2; C512229:di-tert-butylsilylene; C082792:pyripyropene A; C493492:sterol O-acyltransferase 1