title: Takotsubo cardiomyopathy: do the genetics matter?
abstract: Takotsubo cardiomyopathy (TTC) is an enigmatic disease with a multifactorial and still unresolved pathogenesis. Recent experimental and clinical observation has suggested a role for genetics in the pathogenesis of TTC. Ethnic as well as seasonal variation in the prevalence of TTC is well described, but it is only recently that familial cases of TTC have been reported. In recent years technological advances in exome capture and DNA sequencing have offered clinicians a new opportunity to discover genetics-related disease. This article explores the role of genetic mechanisms that might explain or modulate the pathogenesis of TTC.
authors.affiliation: Cardiologia SUN, Monaldi Hospital, AO Colli, Second University of Naples, Via L Bianchi, Naples 80100, Italy. limongelligiuseppe@libero.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Limongelli
authors.forename: Raffaella
authors.initials: R
authors.lastname: D'Alessandro
authors.forename: Daniele
authors.initials: D
authors.lastname: Masarone
authors.forename: Valeria
authors.initials: V
authors.lastname: Maddaloni
authors.forename: Olga
authors.initials: O
authors.lastname: Vriz
authors.forename: Rosalba
authors.initials: R
authors.lastname: Minisini
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Citro
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabrò
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Russo
authors.forename: Raffaele
authors.initials: R
authors.lastname: Calabrò
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pacileo
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bossone
authors.forename: Perry Mark
authors.initials: PM
authors.lastname: Elliott
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D051379:Mice; D011110:Polymorphism, Genetic / Q000235:genetics; D054549:Takotsubo Cardiomyopathy / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology