title: Enhancing retention and efficacy of cardiosphere-derived cells administered after myocardial infarction using a hyaluronan-gelatin hydrogel.
abstract: Cardiosphere-derived cells (CDCs) are under clinical development and are currently being tested in a clinical trial enrolling patients who have undergone a myocardial infarction. CDCs are presently administered via infusion into the infarct-related artery and have been shown in early clinical trials to be effective agents of myocardial regeneration. This review describes the administration of CDCs in a hyaluronan-gelatin hydrogel via myocardial injection and the subsequent improvements in therapeutic benefit seen in animal models. Development of a next generation therapy involving the combination of CDCs and hydrogel is discussed.
authors.affiliation: Capricor Inc.; 8700 Beverly Boulevard; Los Angeles, CA USA.
authors.forename: Rachel Ruckdeschel
authors.initials: RR
authors.lastname: Smith
authors.affiliation: Cedars-Sinai Heart Institute; Los Angeles, CA USA.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Marbán
authors.affiliation: Capricor Inc.; 8700 Beverly Boulevard; Los Angeles, CA USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Marbán
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D002986:Clinical Trials as Topic; D005780:Gelatin / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage / Q000737:chemistry*; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000637:transplantation*
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D005780:Gelatin; D006820:Hyaluronic Acid
keywords: ALLSTAR trial; CADUCEUS trial; cardiosphere-derived cells; hyaluronan-gelatin hydrogel; myocardial infarction
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