title: Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood.
abstract: Assembled polydimethylsiloxane microfluidic devices were modified with a sulfobetaine polymer through continuous "tip-to-tip" modification, significantly reducing blood clotting and extending device patency under blood flow. This technology can be designed to enable the development of devices that can continuously work in whole blood, especially in an extracorporeal or in vivo environment.
authors.affiliation: Semprus BioSciences, MA 02139, USA. Jonathan.Zhang@semprusbio.com
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Borenstein
authors.forename: Linda
authors.initials: L
authors.lastname: Guiney
authors.forename: Raanan
authors.initials: R
authors.lastname: Miller
authors.forename: Sivaprasad
authors.initials: S
authors.lastname: Sukavaneshvar
authors.forename: Christopher
authors.initials: C
authors.lastname: Loose
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001792:Blood Platelets / Q000378:metabolism; D002417:Cattle; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D013927:Thrombosis / Q000503:physiopathology*; D017155:Wettability
chemical_list: D004129:Dimethylpolysiloxanes; D011108:Polymers; C013830:baysilon