title: The variant histone H2A.V of Drosophila--three roles, two guises.
abstract: Histone variants play important roles in eukaryotic genome organization, the control of gene expression, cell division and DNA repair. Unlike other organisms that employ several H2A variants for different functions, the parsimonious fruit fly Drosophila melanogaster gets along with just a single H2A variant, H2A.V. Remarkably, H2A.V unites within one molecule features and functions of two different mammalian H2A variants, H2A.Z and H2A.X. Accordingly, H2A.V is involved in diverse functions, as an element of a class of active promoter structure, as a foundation for heterochromatin assembly and as a DNA damage sensor. Here, we comprehensively review the current knowledge of this fascinating histone variant.
authors.affiliation: Center for Integrated Protein Science, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, 80336 Munich, Germany.
authors.forename: Sandro
authors.initials: S
authors.lastname: Baldi
authors.forename: Peter B
authors.initials: PB
authors.lastname: Becker
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans
chemical_list: D029721:Drosophila Proteins; D006657:Histones
references.citation: Mol Cell. 2004 Nov 19;16(4):655-61
references.pmid: 15546624
references.citation: Nature. 2007 Mar 29;446(7135):572-6
references.pmid: 17392789
references.citation: Mol Plant. 2009 Jul;2(4):565-577
references.pmid: 19825639
references.citation: Genome Res. 2009 Mar;19(3):460-9
references.pmid: 19088306
references.citation: Genetics. 1992 Jun;131(2):345-52
references.pmid: 1644277
references.citation: EMBO J. 2003 Apr 1;22(7):1599-607
references.pmid: 12660166
references.citation: J Biol Chem. 2004 Jun 4;279(23):24274-82
references.pmid: 15020582
references.citation: Proc Natl Acad Sci U S A. 2007 May 29;104(22):9381-6
references.pmid: 17517653
references.citation: Science. 2004 Dec 17;306(5704):2084-7
references.pmid: 15528408
references.citation: Cell. 2007 Feb 23;128(4):693-705
references.pmid: 17320507
references.citation: Chromosoma. 2004 May;112(7):360-71
references.pmid: 15133681
references.citation: EMBO Rep. 2012 Nov 6;13(11):992-6
references.pmid: 22986547
references.citation: Mol Cell Biol. 1999 Sep;19(9):6269-75
references.pmid: 10454573
references.citation: Genes Dev. 2005 Jan 1;19(1):65-76
references.pmid: 15630020
references.citation: Development. 2001 Apr;128(8):1429-41
references.pmid: 11262242
references.citation: Nucleic Acids Res. 2002 Sep 1;30(17):3698-705
references.pmid: 12202754
references.citation: Nature. 2000 Dec 21-28;408(6815):1001-4
references.pmid: 11140636
references.citation: Mol Cell. 2012 Dec 14;48(5):723-33
references.pmid: 23122415
references.citation: Mol Cell Biol. 2012 Jun;32(11):2121-34
references.pmid: 22473994
references.citation: EMBO J. 2002 Mar 1;21(5):1121-31
references.pmid: 11867540
references.citation: Epigenetics Chromatin. 2012 Jun 21;5:7
references.pmid: 22650316
references.citation: PLoS Biol. 2004 May;2(5):E131
references.pmid: 15045029
references.citation: Structure. 2008 Feb;16(2):166-79
references.pmid: 18275809
references.citation: Genes Dev. 2007 Jun 15;21(12):1519-29
references.pmid: 17575053
references.citation: Nucleic Acids Res. 2012 Nov;40(21):10719-41
references.pmid: 23002134
references.citation: Genetics. 2008 Sep;180(1):121-31
references.pmid: 18723888
references.citation: Cell Commun Signal. 2010 Sep 22;8:27
references.pmid: 20860841
references.citation: Cell. 2011 Jan 21;144(2):200-13
references.pmid: 21241891
references.citation: Proc Natl Acad Sci U S A. 1986 Jul;83(13):4744-8
references.pmid: 2425354
references.citation: Proc Natl Acad Sci U S A. 1980 May;77(5):2671-75
references.pmid: 6771757
references.citation: J Biol Chem. 2001 Nov 9;276(45):41945-9
references.pmid: 11551971
references.citation: Nucleic Acids Res. 1988 Aug 11;16(15):7487-97
references.pmid: 3137528
references.citation: Genes Dev. 1995 May 15;9(10):1263-77
references.pmid: 7758950
references.citation: Science. 2004 Jan 16;303(5656):343-8
references.pmid: 14645854
references.citation: Genes Dev. 2006 Mar 15;20(6):711-22
references.pmid: 16543223
references.citation: Genome Biol. 2012 Oct 03;13(10):R85
references.pmid: 23034477
references.citation: Cell. 2000 Oct 27;103(3):411-22
references.pmid: 11081628
references.citation: Mol Cell. 2011 Aug 19;43(4):638-48
references.pmid: 21855802
references.citation: Nat Struct Biol. 2002 Mar;9(3):172-6
references.pmid: 11850638
references.citation: Nat Struct Biol. 2000 Dec;7(12):1121-4
references.pmid: 11101893
references.citation: Cell. 2008 Nov 14;135(4):649-61
references.pmid: 18992931
references.citation: Annu Rev Biochem. 2009;78:273-304
references.pmid: 19355820
references.citation: Cell. 2005 Oct 21;123(2):219-31
references.pmid: 16239141
references.citation: Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12248-53
references.pmid: 15299145
references.citation: Cold Spring Harb Symp Quant Biol. 2010;75:1-9
references.pmid: 21467139
references.citation: Chromosome Res. 2008;16(6):851-62
references.pmid: 18704724
references.citation: J Cell Biol. 2011 Oct 31;195(3):359-67
references.pmid: 22024169
references.citation: Mol Cell. 2007 Nov 30;28(4):692-9
references.pmid: 18042462
references.citation: Mol Cell Biol. 2007 Sep;27(18):6457-68
references.pmid: 17636032
references.citation: Biochim Biophys Acta. 2012 Aug;1819(8):892-901
references.pmid: 22521324
references.citation: Annu Rev Cell Dev Biol. 2005;21:133-53
references.pmid: 16212490
references.citation: J Biol Chem. 2004 Oct 15;279(42):43815-20
references.pmid: 15299007
references.citation: J Cell Sci. 2003 Aug 1;116(Pt 15):3069-77
references.pmid: 12799415
references.citation: Nat Genet. 2005 Oct;37(10):1090-7
references.pmid: 16155569
references.citation: Cold Spring Harb Symp Quant Biol. 2004;69:227-34
references.pmid: 16117653
references.citation: Cell. 2010 Nov 24;143(5):725-36
references.pmid: 21111233
references.citation: Curr Biol. 2001 Aug 7;11(15):1183-7
references.pmid: 11516949
references.citation: Nat Rev Mol Cell Biol. 2010 Apr;11(4):264-75
references.pmid: 20197778
references.citation: Mol Cell. 2012 Jan 13;45(1):64-74
references.pmid: 22178397
references.citation: Environ Mol Mutagen. 2008 Jan;49(1):73-82
references.pmid: 18095327
references.citation: Mol Cell. 2003 Dec;12(6):1565-76
references.pmid: 14690608
references.citation: Trends Cell Biol. 2006 Sep;16(9):433-42
references.pmid: 16904321
references.citation: Science. 1998 Dec 4;282(5395):1900-4
references.pmid: 9836642
references.citation: J Biol Chem. 2010 Feb 12;285(7):4645-51
references.pmid: 19940112
references.citation: Nat Struct Mol Biol. 2010 Dec;17(12):1500-7
references.pmid: 21057526
references.citation: Cell. 2003 Mar 7;112(5):725-36
references.pmid: 12628191
references.citation: Nat Struct Mol Biol. 2005 Feb;12(2):160-6
references.pmid: 15643425
references.citation: Genetics. 2003 Dec;165(4):1929-41
references.pmid: 14704177
references.citation: J Biol Chem. 2010 Jun 4;285(23):17778-88
references.pmid: 20356835
references.citation: Mol Cell Biol. 1996 Aug;16(8):4305-11
references.pmid: 8754831
references.citation: Nature. 1999 Jun 17;399(6737):694-7
references.pmid: 10385122
references.citation: Genes Dev. 2005 Feb 1;19(3):295-310
references.pmid: 15687254
references.citation: Genetics. 2008 Dec;180(4):1869-75
references.pmid: 18845840
references.citation: Genes Cells. 2008 Dec;13(12):1279-88
references.pmid: 19032341
references.citation: Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6205-10
references.pmid: 21444826
references.citation: Biochemistry. 2006 May 2;45(17):5671-7
references.pmid: 16634648
references.citation: Nature. 2009 Jan 1;457(7225):57-62
references.pmid: 19092802
references.citation: Nature. 2011 Mar 24;471(7339):473-9
references.pmid: 21179090
references.citation: PLoS Genet. 2008 Feb 29;4(2):e1000011
references.pmid: 18454204
references.citation: PLoS Genet. 2009 Oct;5(10):e1000687
references.pmid: 19834540
references.citation: Cell Rep. 2012 Apr 19;1(4):350-9
references.pmid: 22523743
references.citation: Mol Biol Cell. 1992 Jun;3(6):593-602
references.pmid: 1498368
references.citation: PLoS One. 2011;6(6):e20511
references.pmid: 21738578
references.citation: Nat Rev Mol Cell Biol. 2009 Jun;10(6):373-84
references.pmid: 19424290
references.citation: Nature. 1997 Sep 18;389(6648):251-60
references.pmid: 9305837
references.citation: PLoS Genet. 2011 Jan 13;7(1):e1001274
references.pmid: 21249180
references.citation: J Biol Chem. 2000 Jul 28;275(30):23267-72
references.pmid: 10801889
references.citation: Nature. 2008 May 15;453(7193):358-62
references.pmid: 18408708
references.citation: Nat Struct Biol. 2003 Nov;10(11):882-91
references.pmid: 14583738
references.citation: Biochim Biophys Acta. 2009 Jan;1789(1):37-44
references.pmid: 18675384
references.citation: Gene. 2006 Aug 15;378:1-10
references.pmid: 16814491
references.citation: Genes Dev. 2001 Nov 1;15(21):2837-51
references.pmid: 11691835
references.citation: Development. 2010 Oct;137(20):3513-22
references.pmid: 20843858