title: Double-blind study with topical Isoconazole and Terbinafine for the treatment of one patient with bilateral Tinea nigra plantaris and suggestions for new differential diagnosis.
abstract: The authors report a case of bilateral Tinea nigra plantaris treated through a double-blind study with the topical antifungal agents Isoconazole and Terbinafine. The objective of the study was to clinically compare the efficacy of these two topical antifungal agents on days 10, 20 and 30 of the treatment. No significant clinical differences were found, as all the plantar lesions regressed completely by the end of the treatment. Our conclusion was that in the case reported, the topical antifungal agents Isoconazole and Terbinafine demonstrated identical efficacy as a clinical cure. We also suggest the inclusion of injuries caused by arthropods of the Diplopoda Class in the differential diagnosis of Tinea nigra plantaris, due to the persistent acral hyperpigmentation.
authors.affiliation: University of Vale do Itajaí/Univali, SC, Brazil. rossettovida@terra.com.br
authors.forename: André Luiz
authors.initials: AL
authors.lastname: Rossetto
authors.forename: Rosana Cé Bella
authors.initials: RC
authors.lastname: Cruz
authors.forename: Vidal
authors.initials: V
authors.lastname: Haddad Junior
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008825:Miconazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009281:Naphthalenes / Q000627:therapeutic use*; D000077291:Terbinafine; D013997:Time Factors; D014008:Tinea Pedis / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D008825:Miconazole; D000077291:Terbinafine; C020382:isoconazole