title: MicroRNA regulation of T-cell differentiation and function.
abstract: MicroRNAs (miRNAs) are emerging as key controllers of T-cell differentiation and function. Their expression is dynamically regulated by extracellular signals such as costimulation and cytokine signals. miRNAs set thresholds for gene expression and optimize protein concentrations of genetic networks. Absence of individual miRNAs can lead to severe immune dysfunction. In this study, we review emerging principles and provide examples of important functions exerted by miRNAs. Although our understanding of miRNA function in T-cell differentiation is still rudimentary, the available evidence leaves no doubt that these small post-transcriptional regulators are indispensable for proper functioning of the immune system.
authors.affiliation: Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Lukas T
authors.initials: LT
authors.lastname: Jeker
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Bluestone
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D016207:Cytokines; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology*; D034622:RNA Interference; D020239:Receptor Cross-Talk; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016207:Cytokines; D035683:MicroRNAs
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