title: Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 130 Scripps Way #3A2, Jupiter, FL 33458, USA.
authors.forename: Valer
authors.initials: V
authors.lastname: Jeso
authors.forename: Sarah
authors.initials: S
authors.lastname: Iqbal
authors.forename: Pamela
authors.initials: P
authors.lastname: Hernandez
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cameron
authors.forename: HaJeung
authors.initials: H
authors.lastname: Park
authors.forename: Philip V
authors.initials: PV
authors.lastname: LoGrasso
authors.forename: Glenn C
authors.initials: GC
authors.lastname: Micalizio
mesh_terms: D016227:Benzoquinones / Q000737:chemistry*; D001665:Binding Sites; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D018841:HSP90 Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D061986:MCF-7 Cells; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism; D062105:Molecular Docking Simulation; D017434:Protein Structure, Tertiary; D017828:Rifabutin / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D012765:Shikimic Acid / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D016227:Benzoquinones; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D008562:Membrane Glycoproteins; C053387:endoplasmin; D017828:Rifabutin; D012765:Shikimic Acid; C004532:quinone