title: Retrospective analysis of Steven Johnson syndrome and toxic epidermal necrolysis over a period of 5 years from northern Karnataka, India.
abstract: OBJECTIVE
  Cutaneous drug reactions are the most common type of adverse drug reactions. Adverse cutaneous drug reactions form 2-3% of the hospitalized patients. 2% of these are potentially serious. This study aims to detect the drugs commonly implicated in Steven Johnson Syndrome-Toxic Epidermal Necrosis (SJS-TEN).
  
  
  METHODS
  A retrospective analysis was done in all patients admitted in the last five years in SDM hospital with the diagnosis of SJS-TEN.
  
  
  RESULTS
  A total of 22 patients with SJS-TEN were studied. In 11 patients anti-epileptics was the causal drug and in 7, anti-microbials was the causal drug. Recovery was much faster in case of anti epileptics induced SJS-TEN as compared to that induced by ofloxacin.
  
  
  CONCLUSIONS
  SJS-TEN induced by ofloxacin has a higher morbidity and mortality compared to anti convulsants.
authors.affiliation: Department of Dermatology, Sri Dharmasthala Manjunatheshwara College of Medical Sciences and Hospital, Dharwad, Karnataka, India.
authors.forename: Kikkeri Narayanasetty
authors.initials: KN
authors.lastname: Naveen
authors.forename: Varadraj V
authors.initials: VV
authors.lastname: Pai
authors.forename: Vijetha
authors.initials: V
authors.lastname: Rai
authors.forename: Sharatchandra B
authors.initials: SB
authors.lastname: Athanikar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000009:adverse effects*; D012189:Retrospective Studies; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000209:etiology*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D015242:Ofloxacin
keywords: Anti-epileptics; Stevens Johnson syndrome; ofloxacin; toxic epidermal necrosis
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