title: Aluminium and radiation cross-linked carboxymethyl sago pulp beads for colon targeted delivery.
abstract: The carboxymethyl sago pulp (CMSP) with a degree of substitution of 0.4% was synthesized from sago waste. The CMSP beads with an average diameter of 3.1-4.8 mm were formed by aluminium chloride gelation as well as further cross-linked by irradiation. To evaluate colon targeted release, a model drug, 5-aminosalicylic acid (5-ASA) was encapsulated in CMSP beads. Fourier-transform infrared spectroscopy and X-ray diffraction studies indicated intact and amorphous nature of entrapped drug. A pH dependent drug release was observed, and about 90% of the drug was released only at pH 7.4 over 9 h. Irradiated beads were resisted the drug release in an acidic environment at a higher extent than non-irradiated beads. The drug release from 6% (w/w) of 5-ASA loaded bead followed zero order, whereas, 15 and 22% loaded beads followed first order. The release exponent n value suggests non-fickian transport of 5-ASA from the beads.
authors.affiliation: School of Science, Monash University, Selangor Darul Ehsan, Malaysia.
authors.forename: Sathasivam
authors.initials: S
authors.lastname: Thenapakiam
authors.forename: Devakumar Ganesh
authors.initials: DG
authors.lastname: Kumar
authors.forename: Janarthanan
authors.initials: J
authors.lastname: Pushpamalar
authors.forename: Muniyandy
authors.initials: M
authors.lastname: Saravanan
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D028023:Arecaceae / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D007700:Kinetics; D019804:Mesalamine / Q000737:chemistry; D008863:Microspheres; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D017607:Aluminum Compounds; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002712:Chlorides; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D020100:Hydrogels; D000077410:Aluminum Chloride; D019804:Mesalamine; D002482:Cellulose