title: Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.
abstract: Trop2 is a cell-surface glycoprotein associated with epithelial carcinomas. Although recent studies indicated that Trop2 is expressed in some stem-like cells, the molecular function of the protein remains largely unknown. In the present study, we observed that acute phase myocardial infarction (MI) induced an increase of c-kit+/Trop2+ cells and found that Trop2 enhanced cardiac c-kit+ cell survival and proliferation via its antiapoptotic activity, due to an elevated activity of ribosomal S6 kinases in the mitogen-activated protein kinase pathway. This study provides insight into better understanding the molecular function of Trop2, which could serve as a potential target for the treatment of MI.
authors.affiliation: Department of Cardiovascular Surgery, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
authors.forename: Jianye
authors.initials: J
authors.lastname: Yang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Hongfei
authors.initials: H
authors.lastname: Wang
authors.forename: Xinling
authors.initials: X
authors.lastname: Du
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000737:chemistry / Q000378:metabolism*; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D001483:Base Sequence; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000378:metabolism*; D049109:Cell Proliferation; D016207:Cytokines / Q000494:pharmacology; D004195:Disease Models, Animal; D015870:Gene Expression; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006321:Heart / Q000187:drug effects; D018836:Inflammation Mediators / Q000494:pharmacology; D008297:Male; D051379:Mice; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009203:Myocardial Infarction / Q000235:genetics / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000737:chemistry / Q000235:genetics; D015398:Signal Transduction
chemical_list: D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D016207:Cytokines; D018836:Inflammation Mediators; D034741:RNA, Small Interfering; C544766:TROP2 protein, mouse; D019009:Proto-Oncogene Proteins c-kit; D020928:Mitogen-Activated Protein Kinases