title: Gastric cancer prevention by demethylation.
abstract: Niwa and colleagues report in this issue that treatment with the DNA demethylation agent 5-aza-2'-deoxycytidine decreases the incidence of gastric cancers in an animal model of Helicobacter pylori-promoted gastric cancer. This provocative study underscores the importance of changes in DNA methylation that contribute to the origin of inflammation-related cancers. The findings also raise the exciting possibility of cancer prevention by altering DNA methylation events early during tumorigenesis.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. barbara.schneider@vanderbilt.edu
authors.forename: Barbara G
authors.initials: BG
authors.lastname: Schneider
authors.forename: Richard M
authors.initials: RM
authors.lastname: Peek
mesh_terms: D000230:Adenocarcinoma / Q000382:microbiology* / Q000517:prevention & control*; D000818:Animals; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015257:DNA-Cytosine Methylases / Q000037:antagonists & inhibitors*; D000077209:Decitabine; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000502:physiology*; D008297:Male; D013274:Stomach Neoplasms / Q000382:microbiology* / Q000517:prevention & control*
chemical_list: D000077209:Decitabine; D015257:DNA-Cytosine Methylases; D001374:Azacitidine
references.citation: Clin Cancer Res. 2006 May 15;12(10):3216-21
references.pmid: 16707623
references.citation: Cancer Prev Res (Phila). 2013 Apr;6(4):263-70
references.pmid: 23559452
references.citation: Digestion. 2007;75(1):54-61
references.pmid: 17438355
references.citation: Lancet Oncol. 2012 Jun;13(6):607-15
references.pmid: 22575588
references.citation: J Exp Med. 2005 Nov 7;202(9):1235-47
references.pmid: 16275761
references.citation: Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):989-95
references.pmid: 16467114
references.citation: Am J Gastroenterol. 2007 Jul;102(7):1361-71
references.pmid: 17509026
references.citation: Cancer Res. 2010 Feb 15;70(4):1430-40
references.pmid: 20124475
references.citation: Gastroenterology. 2003 Dec;125(6):1636-44
references.pmid: 14724815
references.citation: J Biol Chem. 1992 Jan 5;267(1):166-72
references.pmid: 1730583
references.citation: Cancer Res. 2004 Dec 1;64(23):8521-5
references.pmid: 15574757
references.citation: Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):1003-8
references.pmid: 18192401
references.citation: Cancer Cell. 2011 Nov 15;20(5):606-19
references.pmid: 22094255
references.citation: J Biomed Biotechnol. 2012;2012:623019
references.pmid: 22363173
references.citation: J Immunol. 2005 Mar 15;174(6):3658-67
references.pmid: 15749904
references.citation: Science. 2003 May 30;300(5624):1430-4
references.pmid: 12775840
references.citation: Nature. 2007 May 17;447(7142):330-3
references.pmid: 17507984
references.citation: Cancer Chemother Pharmacol. 2013 Jan;71(1):115-21
references.pmid: 23053268
references.citation: Ann Hematol. 2012 Dec;91(12):1879-86
references.pmid: 22895556
references.citation: Nat Rev Genet. 2006 Jan;7(1):21-33
references.pmid: 16369569
references.citation: Cancer Sci. 2012 Oct;103(10):1839-47
references.pmid: 22816487
references.citation: Cancer Res. 1995 May 15;55(10):2111-5
references.pmid: 7743510
references.citation: J Cell Biol. 2003 Apr 28;161(2):249-55
references.pmid: 12719469
references.citation: Cancer Res. 1996 Jul 15;56(14):3238-43
references.pmid: 8764115
references.citation: Lancet. 1991 Aug 10;338(8763):332-5
references.pmid: 1677696
references.citation: J Biol Chem. 1998 Mar 6;273(10):5858-68
references.pmid: 9488723
references.citation: CA Cancer J Clin. 2013 Jan;63(1):11-30
references.pmid: 23335087
references.citation: Gut. 2003 Apr;52(4):502-6
references.pmid: 12631658
references.citation: Cancer Res. 2008 Dec 15;68(24):10280-9
references.pmid: 19074896
references.citation: Int J Cancer. 2010 Dec 1;127(11):2588-97
references.pmid: 20178103
references.citation: Clin Cancer Res. 2012 Feb 15;18(4):923-9
references.pmid: 22205689