title: A severe case of haemodynamic instability during anidulafungin administration.
abstract: OBJECTIVE
  Anidulafugin is an echinocandin used for the treatment of candida infections in non-neutropenic adults. Echinocandins show few drug-drug interactions and are usually well tolerated. We report a case of acute hypotension, bradycardia and haemodynamic instability with consecutive cardiopulmonary resuscitation during anidulafungin administration.
  
  
  METHODS
  A 41-year-old man ICU patient received anidulafungin for a suspected Candida glabrata infection. During the first administration of the drug, he developed acute haemodynamic instability with hypotension and bradycardia. The infusion was discontinued immediately and cardiopulmonary resuscitation was performed successfully. The patient regained haemodynamic stability.
  
  
  CONCLUSIONS
  To the authors' knowledge, this is the first report of a life-threatening adverse event due to haemodynamic instability during anidulafungin administration. Cardiac toxicity associated with echinocandins has been described. Further studies seem to be mandatory to investigate this potential risk.
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, Klinikum Klagenfurt am Wörthersee, Klagenfurt, Austria. martina.fink@kabeg.at
authors.forename: M
authors.initials: M
authors.lastname: Fink
authors.forename: U
authors.initials: U
authors.lastname: Zerlauth
authors.forename: C
authors.initials: C
authors.lastname: Kaulfersch
authors.forename: A
authors.initials: A
authors.lastname: Rab
authors.forename: D
authors.initials: D
authors.lastname: Alberer
authors.forename: P
authors.initials: P
authors.lastname: Preiss
authors.forename: K
authors.initials: K
authors.lastname: Sternad-Klobschauer
authors.forename: E
authors.initials: E
authors.lastname: Habernig
authors.forename: W
authors.initials: W
authors.lastname: Wandschneider
authors.forename: G
authors.initials: G
authors.lastname: Grimm
mesh_terms: D000328:Adult; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001919:Bradycardia / Q000139:chemically induced*; D041221:Candida glabrata / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy / Q000378:metabolism; D054714:Echinocandins / Q000008:administration & dosage* / Q000009:adverse effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D008297:Male
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin