title: Clinical experience of modified diffusion-weighted imaging protocol for lesion detection in transient global amnesia: an 8-year large-scale clinical study.
abstract: OBJECTIVE
  The detection rate of typical transient global amnesia (TGA) lesions on diffusion-weighted imaging (DWI) can be improved, up to 85% with optimal DWI parameters and imaging time. There is limited evidence that these findings are similar to those observed in large-scale consecutive patients with TGA in clinical practice.
  
  
  METHODS
  Patients with clinically diagnosed TGA underwent magnetic resonance imaging studies, consecutively, with three sets of DWI parameters (standard clinical DWI protocols, the TGA DWI protocol I and the TGA DWI protocol II) in which the resolution, slice thickness, and the time interval between symptom onset of DWI were varied over an 8-year period.
  
  
  RESULTS
  TGA lesion detection rates were up to 88% with a modified TGA DWI protocol. The lesion detection rate was the highest using TGA DWI protocol I, with b = 3,000 s/mm(2), a slice thickness of 3 mm, and performed on the third day after symptom onset, and TGA DWI protocol II, with b = 2,000 s/mm(2) and a slice thickness of 2 mm.
  
  
  CONCLUSIONS
  A modified TGA DWI protocols for detecting TGA lesions are useful in large-scale clinical practice for confirming the diagnosis of TGA patients with clinical findings.
authors.affiliation: Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Jungeun
authors.initials: J
authors.lastname: Kim
authors.forename: Yooseok
authors.initials: Y
authors.lastname: Kwon
authors.forename: Youngsoon
authors.initials: Y
authors.lastname: Yang
authors.forename: Il Mi
authors.initials: IM
authors.lastname: Jang
authors.forename: YoungHee
authors.initials: Y
authors.lastname: Chang
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Park
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Jang
authors.forename: Jae Hyoung
authors.initials: JH
authors.lastname: Kim
authors.forename: SangYun
authors.initials: S
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D020236:Amnesia, Transient Global / Q000453:epidemiology* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012042:Registries; D015203:Reproducibility of Results; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012680:Sensitivity and Specificity
keywords: Transient global amnesia; clinical study; diffusion-weighted imaging protocol