title: St. John's wort for the treatment of psychiatric disorders.
abstract: St. John's wort (Hypericum perforatum) has been extensively studied and reviewed for its use in depression; however, there is less salient discussion on its clinical application for a range of other psychiatric disorders. This article outlines the current evidence of the efficacy of St John's wort in common psychiatric disorders, including major depression, bipolar depression, attention-deficit hyperactivity disorder, obsessive-compulsive disorder, social phobia, and somatization disorder. Mechanisms of action, including emerging pharmacogenetic data, safety, and clinical considerations are also detailed.
authors.affiliation: Department of Psychiatry, The Melbourne Clinic, The University of Melbourne, 2 Salisbury Street, Richmond, Victoria 3121, Australia. jsarris@unimelb.edu.au
authors.forename: Jerome
authors.initials: J
authors.lastname: Sarris
mesh_terms: D002986:Clinical Trials as Topic; D041743:Herb-Drug Interactions; D006801:Humans; D020902:Hypericum; D001523:Mental Disorders / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts