title: An Improved Synthesis of BrettPhos and RockPhos-Type Biarylphosphine Ligands.
abstract: Improved processes for the preparation of biphenyl-based phosphine ligandst-BuBrettPhos, RockPhos, and BrettPhos are presented. The new methods, featuring the use of Grignard reagents and catalytic amounts of copper, are superior to the previous methods, which require the use oft-butyllithium and stoichiometric amounts of copper. Specifically, the use of less dangerous reagents provides a safer process, while the use of catalytic amounts of copper allows for the isolation of pure products in high yield. These improvements are particularly significant for the large scale preparation of these ligands.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hoshiya
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
keywords: Copper; Cross-coupling; P ligands; Synthetic methods
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