title: Recent advances in research of HIV infection: implications of viral and host genetics on treatment and prevention.
abstract: The genetic diversity among human immunodeficiency virus (HIV) subtypes as well as the variability of viral sequences found in HIV-infected individuals presents a number of difficult obstacles for the development of universally effective HIV treatment and prevention methods. Here, we present a brief summary of recent developments in the analysis of viral genetics and human genomics to provide insight into future methods for HIV treatment and prevention. Recent studies have mined viral sequences found in newly infected individuals to identify common features of all transmitted viruses that could provide potential targets for HIV vaccine development. Analysis of human immunogenetics has identified specific alleles associated with reduced virus loads in HIV-infected individuals providing valuable information that may influence individual responses to treatment and prevention methods. Increased sensitivity of antiretroviral drug resistance testing has improved the detection of hidden drug resistant virus but also highlighted the potential for drug resistant viruses to reduce the effectiveness of clinical treatment regimens. The rapidly expanding amount of data generated by studies of viral genetics and human immunogenetics will provide valuable information to guide the design of new strategies to improve clinical treatment and enhance HIV vaccine development.
authors.affiliation: Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA. hyw9@cdc.gov
authors.forename: R E
authors.initials: RE
authors.lastname: Haaland
authors.forename: J A
authors.initials: JA
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Tang
mesh_terms: D016915:AIDS Vaccines; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D005814:Genes, Viral; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D023281:Genomics; D006678:HIV / Q000145:classification / Q000235:genetics*; D015658:HIV Infections / Q000235:genetics* / Q000517:prevention & control / Q000628:therapy* / Q000821:virology*; D006801:Humans; D019562:Viral Load
chemical_list: D016915:AIDS Vaccines; D044966:Anti-Retroviral Agents
references.citation: Hum Mol Genet. 2012 Oct 1;21(19):4334-47
references.pmid: 22718199
references.citation: PLoS One. 2011;6(5):e19461
references.pmid: 21602929
references.citation: J Virol. 2012 Nov;86(21):11493-500
references.pmid: 22896606
references.citation: J Virol. 2012 Jan;86(1):277-83
references.pmid: 22031937
references.citation: PLoS One. 2012;7(2):e30118
references.pmid: 22355307
references.citation: PLoS Pathog. 2010 Oct 14;6(10):e1001033
references.pmid: 20976252
references.citation: Nat Methods. 2007 Feb;4(2):123-5
references.pmid: 17206150
references.citation: Viruses. 2011 Nov;3(11):2255-79
references.pmid: 22163344
references.citation: Science. 2010 Dec 10;330(6010):1551-7
references.pmid: 21051598
references.citation: J Clin Microbiol. 2005 Jan;43(1):406-13
references.pmid: 15635002
references.citation: Sci Transl Med. 2011 May 4;3(81):81ra36
references.pmid: 21543722
references.citation: Vaccine. 2012 Jan 20;30(5):832-6
references.pmid: 22085554
references.citation: Virology. 2011 Mar 1;411(1):113-31
references.pmid: 21239033
references.citation: Annu Rev Med. 2013;64:203-17
references.pmid: 23020875
references.citation: J Clin Microbiol. 2006 Jul;44(7):2612-4
references.pmid: 16825395
references.citation: Clin Infect Dis. 2011 Oct;53(7):732-42
references.pmid: 21890778
references.citation: J Infect Dis. 2011 Mar 15;203(6):803-9
references.pmid: 21257739
references.citation: PLoS Pathog. 2012;8(3):e1002529
references.pmid: 22412369
references.citation: PLoS One. 2009 Jun 29;4(6):e6079
references.pmid: 19562031
references.citation: Nature. 2005 Sep 15;437(7057):376-80
references.pmid: 16056220
references.citation: AIDS Res Hum Retroviruses. 2012 May;28(5):527-30
references.pmid: 21902588
references.citation: Lancet. 2008 Nov 29;372(9653):1881-1893
references.pmid: 19012954
references.citation: PLoS One. 2007 Jul 25;2(7):e638
references.pmid: 17653265
references.citation: Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13353-8
references.pmid: 22826228
references.citation: PLoS Med. 2008 Jul 29;5(7):e158
references.pmid: 18666824
references.citation: Curr Opin HIV AIDS. 2010 Jul;5(4):327-34
references.pmid: 20543609
references.citation: J Virol. 2011 Sep;85(17):8894-902
references.pmid: 21715491
references.citation: Nat Med. 2011 Mar;17(3):366-71
references.pmid: 21358627
references.citation: J Infect Dis. 2009 Mar 1;199(5):693-701
references.pmid: 19210162
references.citation: Proc Natl Acad Sci U S A. 2006 May 2;103(18):7094-9
references.pmid: 16641095
references.citation: Nature. 2011 Aug 03;476(7358):96-100
references.pmid: 21814282
references.citation: Nature. 2011 Apr 28;472(7344):495-8
references.pmid: 21499264
references.citation: PLoS Pathog. 2011 Sep;7(9):e1002209
references.pmid: 21980282
references.citation: PLoS One. 2011;6(8):e23673
references.pmid: 21876761
references.citation: AIDS. 2011 Jan 28;25(3):325-33
references.pmid: 21157296