title: In vivo evaluation of curcumin-loaded nanoparticles in a A549 xenograft mice model.
abstract: Curcumin (Cum) has been reported to have potential chemo-preventive and chemotherapeutic activity through influencing various processes, inducing cell cycle arrest, differentiation and apoptosis in a series of cancers. However, the poor solubility of Cum limits its further applications in the treatment of cancer. We have previously reported Cum-loaded nanoparticles (Cum-NPs) prepared with amphilic methoxy poly(ethylene glycol)-polycaprolactone (mPEG-PCL) block copolymers. The current study demonstrated superior antitumor efficacy of Cum-NPs over free Cum in the treatment of lung cancer. In vivo evaluation further demonstrated superior anticancer effects of Cum-NPs by delaying tumor growth compared to free Cum in an established A549 transplanted mice model. Moreover, Cum-NPs showed little toxicity to normal tissues including bone marrow, liver and kidney at a therapeutic dose. These results suggest that Cum-NPs are effective to inhibit the growth of human lung cancer with little toxicity to normal tissues, and could provide a clinically useful therapeutic regimen. They thus merit more research to evaluate the feasibility of clinical application.
authors.affiliation: Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University, Nanjing, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Yin
authors.forename: De-Geng
authors.initials: DG
authors.lastname: Zhang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Wu
authors.forename: Xin-En
authors.initials: XE
authors.lastname: Huang
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003474:Curcumin / Q000009:adverse effects / Q000627:therapeutic use*; D004337:Drug Carriers / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000009:adverse effects / Q000627:therapeutic use*; D011091:Polyesters / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000627:therapeutic use; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011091:Polyesters; C439611:methoxy poly(ethylene glycol-co-epsilon-caprolactone); D011092:Polyethylene Glycols; D003474:Curcumin