title: Survival after surgery for hepatocellular carcinoma in relation to presence or absence of viral infection.
abstract: BACKGROUND
  The aim of this study was to compare postoperative survival between hepatocellular carcinoma (HCC) patients with and without viral infection.
  
  
  METHODS
  From among 398 HCC patients in our collected database, 377 who underwent surgery were enrolled. The patients were divided into 2 groups: group 1, those who had no hepatitis B virus or hepatitis C virus infection, and group 2, those who had hepatitis B virus or hepatitis C virus infection. Univariate analysis was performed to compare clinical factors, including viral infection, with overall survival. Kaplan-Meier analysis and the log-rank test were used to evaluate the overall and disease-free survival curves for the 2 groups.
  
  
  RESULTS
  Univariate analysis showed that viral infection showed no such association. Moreover, Kaplan-Meier analysis and the log-rank test revealed no significant intergroup differences in either overall or disease-free survival.
  
  
  CONCLUSIONS
  The presence or absence of viral infection shows no significant association with the postoperative survival of patients undergoing surgery for HCC.
authors.affiliation: Department of Gastroenterological Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan. mm-ishizuka@umin.ac.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ishizuka
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kubota
authors.forename: Junji
authors.initials: J
authors.lastname: Kita
authors.forename: Mitsugi
authors.initials: M
authors.lastname: Shimoda
authors.forename: Masato
authors.initials: M
authors.lastname: Kato
authors.forename: Tokihiko
authors.initials: T
authors.lastname: Sawada
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality* / Q000601:surgery* / Q000821:virology; D016208:Databases, Factual; D018572:Disease-Free Survival; D005234:Fatty Liver / Q000150:complications; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; Postoperative survival; Viral infection