title: Rumination and impaired cortisol recovery following a social stressor in adolescent depression.
abstract: Response styles theory promotes rumination as a central cognitive construct driving negative mood and depression, and past research suggests that at least part of the mechanism driving rumination's depressogenic effect is through inhibiting the individual's ability to shift attentional focus away from negative environmental stimuli. In the current study, we hypothesized that high trait rumination would be associated with impaired recovery of the body's biological response to psychological stress. In a community sample of depressed (n = 31) and non-depressed (n = 33) adolescents we assessed rumination and the more adaptive trait of distraction and problem-solving with the Children's Response Styles Questionnaire (CRSQ; Abela 2000), and diagnostic status was confirmed using the Child and Adolescent Schedule of Affective Disorders and Schizophrenia (K-SADS; Kaufman et al. Journal of the American Academy of Child and Adolescent Psychiatry 36:980-988, 1997). Participants completed the Trier Social Stress Test (TSST; Kirschbaum et al. Neuropsychobiology 28:76-81, 1993), and the focus of our analyses was the change in salivary cortisol concentration between peak cortisol output (25 min post-stressor) and a sample taken during the "Recovery" period 65 minutes post-stressor. Consistent with the predictions of response style theory, among the depressed adolescents only, high trait rumination was associated with delayed post-stressor cortisol recovery, whereas high trait distraction and problem-solving was associated with more rapid recovery. In contrast, response styles were not associated with cortisol recovery in the non-depressed group. These findings implicate impaired post-stress cortisol recovery as a potential mechanism underlying the pathological effect of rumination on the development and maintenance of Major Depressive Disorder (MDD).
authors.affiliation: Department of Psychology, Queen's University, Kingston, Ontario, Canada, K7L 3N6. 2js4@queensu.ca
authors.forename: Jeremy G
authors.initials: JG
authors.lastname: Stewart
authors.forename: Raegan
authors.initials: R
authors.lastname: Mazurka
authors.forename: Lea
authors.initials: L
authors.lastname: Bond
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Wynne-Edwards
authors.forename: Kate L
authors.initials: KL
authors.lastname: Harkness
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D003865:Major Depressive Disorder / Q000378:metabolism* / Q000523:psychology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D008297:Male; D009864:Ontario; D010913:Pituitary-Adrenal System / Q000378:metabolism; D012044:Regression Analysis; D012463:Saliva; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D006854:Hydrocortisone
references.citation: Psychoneuroendocrinology. 2008 May;33(4):517-29
references.pmid: 18337016
references.citation: Biol Psychiatry. 2003 Aug 1;54(3):200-7
references.pmid: 12893096
references.citation: Biol Psychiatry. 2002 May 1;51(9):693-707
references.pmid: 11983183
references.citation: J Abnorm Psychol. 1991 Nov;100(4):569-82
references.pmid: 1757671
references.citation: J Abnorm Psychol. 2002 May;111(2):350-6
references.pmid: 12003456
references.citation: J Cogn Neurosci. 2010 Feb;22(2):248-62
references.pmid: 19400679
references.citation: Perspect Psychol Sci. 2008 Sep;3(5):400-24
references.pmid: 26158958
references.citation: J Abnorm Psychol. 1995 Feb;104(1):15-25
references.pmid: 7897037
references.citation: J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8
references.pmid: 9204677
references.citation: J Abnorm Psychol. 1997 May;106(2):221-9
references.pmid: 9131842
references.citation: Am J Psychiatry. 2007 Apr;164(4):617-21
references.pmid: 17403975
references.citation: Horm Behav. 2003 Jan;43(1):2-15
references.pmid: 12614627
references.citation: Psychosom Med. 2008 Jul;70(6):661-7
references.pmid: 18606726
references.citation: J Pers Soc Psychol. 2008 Jul;95(1):197-211
references.pmid: 18605860
references.citation: J Pers Soc Psychol. 1993 Aug;65(2):339-49
references.pmid: 8366423
references.citation: Stress. 2010 Sep;13(5):435-43
references.pmid: 20666646
references.citation: Psychoneuroendocrinology. 2010 Jul;35(6):921-31
references.pmid: 20079576
references.citation: Cogn Affect Behav Neurosci. 2005 Jun;5(2):156-68
references.pmid: 16180622
references.citation: Paediatr Perinat Epidemiol. 2001 Jan;15(1):88-94
references.pmid: 11237120
references.citation: Biol Psychiatry. 2006 Oct 15;60(8):831-6
references.pmid: 16945344
references.citation: Clin Chem. 2003 Oct;49(10):1688-91
references.pmid: 14500602
references.citation: Psychol Med. 2003 May;33(4):601-10
references.pmid: 12785462
references.citation: J Affect Disord. 2001 Jan;62(1-2):77-91
references.pmid: 11172875
references.citation: J Abnorm Psychol. 1993 Feb;102(1):20-8
references.pmid: 8436695
references.citation: J Abnorm Child Psychol. 2012 Feb;40(2):317-26
references.pmid: 21826445
references.citation: J Pers Soc Psychol. 1998 Jul;75(1):166-77
references.pmid: 9686457
references.citation: J Pers Soc Psychol. 1995 Jul;69(1):176-90
references.pmid: 7643299
references.citation: J Abnorm Psychol. 2000 Nov;109(4):644-50
references.pmid: 11195988
references.citation: J Pers Soc Psychol. 1994 Jul;67(1):92-104
references.pmid: 8046585
references.citation: Psychoneuroendocrinology. 2009 Oct;34(9):1272-83
references.pmid: 19406581
references.citation: Biol Psychiatry. 2008 Sep 15;64(6):521-6
references.pmid: 18597740
references.citation: Arch Gen Psychiatry. 2003 Dec;60(12):1248-55
references.pmid: 14662557
references.citation: Soc Cogn Affect Neurosci. 2009 Dec;4(4):313-27
references.pmid: 19620180
references.citation: J Pers Soc Psychol. 1999 Oct;77(4):801-14
references.pmid: 10531672
references.citation: Psychoneuroendocrinology. 2005 Oct;30(9):846-56
references.pmid: 15961250
references.citation: Psychoneuroendocrinology. 2001 Apr;26(3):319-29
references.pmid: 11166494
references.citation: J Pers Soc Psychol. 1991 Jul;61(1):115-21
references.pmid: 1890582
references.citation: Arch Gen Psychiatry. 1981 Apr;38(4):408-13
references.pmid: 7212971
references.citation: J Abnorm Child Psychol. 2007 Dec;35(6):913-27
references.pmid: 17549619
references.citation: Psychol Bull. 2004 May;130(3):355-91
references.pmid: 15122924
references.citation: Behav Res Ther. 1988;26(2):151-8
references.pmid: 3365205
references.citation: Psychoneuroendocrinology. 2001 Feb;26(2):165-73
references.pmid: 11087962
references.citation: Mayo Clin Proc. 2001 Jun;76(6):582-92
references.pmid: 11393496
references.citation: Neuropsychobiology. 1993;28(1-2):76-81
references.pmid: 8255414
references.citation: Psychoneuroendocrinology. 2011 Feb;36(2):173-81
references.pmid: 20688438
references.citation: Biol Psychiatry. 2008 Mar 15;63(6):577-86
references.pmid: 17888411
references.citation: Depress Anxiety. 1998;7(1):3-14
references.pmid: 9592628