title: [Effects of propofol pretreatment on endothelin in oleic acid-induced acute lung injury].
abstract: BACKGROUND
  Acute lung injury (ALI) is a pathological condition characterized by injury in the alveolar-capillary membrane that triggers local and systemic inflammation. Endothelin (ET) is a protein that regulates immune response and constricts blood vessels; when it is over-expressed, it may contribute to high blood pressure and lung injury. This work tries to determine if propofol may decrease hemodynamic, gasometric, microscopic, ET-1 plasmatic concentration, and immuno-histochemical alterations in an experimental model of oleic acid-induced acute lung injury. MATERIALS AND METHODS. Animals were classified into three groups (n = 6): group I was the control group; in group II, there was oleic acid-induced ALI with no treatment, and group III with propofol pre-treatment and oleic acid-induced ALI.
  
  
  RESULTS
  All animals survived until the end of the study, and 100% of group II and group III developed ALI, with hemodynamic, gasometric and gravimetric alterations. However, group III showed less inflammatory infiltration and lower ET-1 expression in lung tissue.
  
  
  CONCLUSIONS
  Pretreatment with propofol in a canine model of OA-induced ALI indicates that the drug has anti-inflammatory action, with a potential therapeutic role against progression of anti-inflammation and lung damage.
authors.affiliation: Departamento de Cirugia Experimental, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas. claudia_herjim@yahoo.com
authors.forename: Claudia
authors.initials: C
authors.lastname: Hernández-Jiménez
authors.forename: Juan Raúl
authors.initials: JR
authors.lastname: Olmos-Zúñiga
authors.forename: Rogelio
authors.initials: R
authors.lastname: Jasso-Victoria
authors.forename: Miguel
authors.initials: M
authors.lastname: Gaxiola-Gaxiola
authors.forename: Matilde
authors.initials: M
authors.lastname: Baltazares-Lipp
authors.forename: Lidia Saraí
authors.initials: LS
authors.lastname: Sánchez-Arrozena
authors.forename: Luis Horacio
authors.initials: LH
authors.lastname: Gutiérrez-González
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced*; D000818:Animals; D004285:Dogs; D016232:Endothelins / Q000187:drug effects*; D005260:Female; D008297:Male; D009829:Oleic Acids / Q000008:administration & dosage; D015742:Propofol / Q000494:pharmacology*
chemical_list: D016232:Endothelins; D009829:Oleic Acids; D015742:Propofol