title: Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats.
abstract: Glycine is a well-documented cytoprotective agent. However, whether it has a protective effect against myocardial ischemia-reperfusion injury in vivo is still unknown. By using an open-chest anesthetized rat model, we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats. The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%, respectively, in glycine-treated rats. The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment. Importantly, administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium, which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase, as well as the Fas ligand. These results suggest that glycine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis.
authors.affiliation: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China;
authors.forename: Xiaozheng
authors.initials: X
authors.lastname: Zhong
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
authors.forename: Lingling
authors.initials: L
authors.lastname: Qian
authors.forename: Yiming
authors.initials: Y
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Xudong
authors.initials: X
authors.lastname: Zhu
authors.forename: Jingjing
authors.initials: J
authors.lastname: Ben
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
keywords: apoptosis; cardiomyocytes; glycine; glycine receptor α2 subunit; ischemia reperfusion
references.citation: Arch Biochem Biophys. 1982 Sep;217(2):609-23
references.pmid: 7138028
references.citation: Curr Opin Pharmacol. 2008 Apr;8(2):141-6
references.pmid: 18289939
references.citation: Mol Cell Biol. 2006 Mar;26(6):2118-29
references.pmid: 16507991
references.citation: Transplantation. 2008 May 15;85(9):1300-10
references.pmid: 18475188
references.citation: Circulation. 2000 Mar 14;101(10):1172-8
references.pmid: 10715265
references.citation: J Radiat Res. 2001 Jun;42(2):201-15
references.pmid: 11599886
references.citation: Cardiovasc Res. 2004 Feb 15;61(3):427-36
references.pmid: 14962474
references.citation: Am Heart J. 1999 Aug;138(2 Pt 2):S69-75
references.pmid: 10426862
references.citation: Circulation. 1999 Apr 6;99(13):1685-91
references.pmid: 10190877
references.citation: Acta Anaesthesiol Scand. 2005 Sep;49(8):1108-16
references.pmid: 16095452
references.citation: Transpl Int. 2006 Mar;19(3):218-24
references.pmid: 16441771
references.citation: J Cell Biol. 1996 Apr;133(2):335-43
references.pmid: 8609166
references.citation: Nutrition. 2003 Sep;19(9):817-8
references.pmid: 12921899
references.citation: Acta Pharmacol Sin. 2009 Aug;30(8):1107-14
references.pmid: 19617896
references.citation: Cerebrovasc Dis. 2000 Jan-Feb;10(1):49-60
references.pmid: 10629347
references.citation: Liver Int. 2007 Nov;27(9):1249-54
references.pmid: 17919237
references.citation: J Physiol. 2004 Aug 1;558(Pt 3):873-82
references.pmid: 15218075
references.citation: Clin Nutr. 2008 Oct;27(5):773-80
references.pmid: 18692283
references.citation: Brain Res. 1981 Dec 7;226(1-2):273-9
references.pmid: 6271346
references.citation: Surgery. 2003 Sep;134(3):457-66
references.pmid: 14555933
references.citation: Biochem J. 2005 Sep 1;390(Pt 2):447-53
references.pmid: 15836436
references.citation: J Gastroenterol Hepatol. 2011 Jan;26(1):194-200
references.pmid: 21175814
references.citation: Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9679-84
references.pmid: 16763051
references.citation: Am J Physiol Heart Circ Physiol. 2003 Feb;284(2):H456-63
references.pmid: 12414449
references.citation: Eur J Cell Biol. 2011 Apr;90(4):333-41
references.pmid: 21122942
references.citation: J Mol Cell Cardiol. 1999 Aug;31(8):1429-34
references.pmid: 10423341
references.citation: Ann Plast Surg. 2001 Mar;46(3):320-6
references.pmid: 11293527
references.citation: Mol Cell Biol. 1997 Jan;17(1):24-35
references.pmid: 8972182
references.citation: Psychopharmacology (Berl). 2008 Feb;196(3):451-60
references.pmid: 17952411
references.citation: Am J Physiol Renal Physiol. 2002 Mar;282(3):F417-23
references.pmid: 11832421
references.citation: JPEN J Parenter Enteral Nutr. 2007 May-Jun;31(3):173-80
references.pmid: 17463141
references.citation: Transpl Int. 2005 Sep;18(9):1079-89
references.pmid: 16101730
references.citation: Eur Surg Res. 2011;46(4):180-7
references.pmid: 21454985
references.citation: J Neurosci. 2007 Mar 14;27(11):2846-57
references.pmid: 17360906
references.citation: Eur Surg Res. 2006;38(6):503-12
references.pmid: 17028433
references.citation: Neuron. 2005 Mar 3;45(5):727-39
references.pmid: 15748848