title: Gastric neuroendocrine carcinoma with non-islet cell tumor hypoglycemia associated with enhanced production of insulin-like growth factor II.
abstract: A 75-year-old man was admitted to the hospital with a loss of consciousness. His blood glucose level was 24 mg/dL. Abdominal computed tomography revealed multiple metastatic lesions in the liver, while upper endoscopy disclosed advanced gastric cancer. The hypoglycemia was refractory despite the administration of glucose and steroid therapy. The patient died within one month of admission. An autopsy revealed neuroendocrine-type gastric cancer, which, on examination with immunohistochemistry, was found to be negative for insulin and insulin-like growth factor I and positive for insulin-like growth factor II (IGF-II). The patient was diagnosed as having gastric cancer with non-islet cell tumor hypoglycemia (NICTH) caused by IGF-II.
authors.affiliation: Department of Gastroenterology, Omori Red Cross Hospital, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ida
authors.forename: Taiki
authors.initials: T
authors.lastname: Morohashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohara
authors.forename: Toru
authors.initials: T
authors.lastname: Goto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inamori
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
authors.forename: Shin
authors.initials: S
authors.lastname: Maeda
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tsukumo
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ishikawa
mesh_terms: D007516:Adenoma, Islet Cell; D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000175:diagnosis; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008297:Male; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D007335:Insulin-Like Growth Factor II