title: Transcription-replication encounters, consequences and genomic instability.
abstract: To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between transcription and replication processes and how different types of encounters between RNA- and DNA-polymerase complexes may result in clashes of those machineries on the DNA template and thus increase genomic instability. In addition, we summarize strategies evolved in bacteria and eukaryotes to minimize the consequences of collisions, including R-loop formation and topological stresses.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique UMR 7104, Institut National de la Santé et de la Recherche Médicale U 964, Université de Strasbourg, Illkirch, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Helmrich
authors.forename: Monica
authors.initials: M
authors.lastname: Ballarino
authors.forename: Evgeny
authors.initials: E
authors.lastname: Nudler
authors.forename: Laszlo
authors.initials: L
authors.lastname: Tora
mesh_terms: D004261:DNA Replication; D042822:Genomic Instability; D014158:Transcription, Genetic
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