title: The associations between serum paraoxonase 1 activity and carotid atherosclerosis in renal transplant patients.
abstract: OBJECTIVE
  Paraoxonase 1 (PON1) is a novel marker that has been shown to exert protective functions on atherosclerosis by preventing oxidative modification of serum lipoproteins. In this study, we investigated the effects of PON1 on CA-IMT in renal transplant patients.
  
  
  METHODS
  A total of 98 adult renal transplant recipients was enrolled in the study. CA-IMT was determined by B-mode Doppler ultrasonography. PON-1 activity was assessed by the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol.
  
  
  RESULTS
  Mean age was 39.4 ± 9.6 years and 10% of the patients were diabetic. Time after transplant was 76 ± 59 months. Mean PON1 level was 62.1 ± 43.3 U/l. PON1 levels were negatively correlated with CA-IMT and positively with HDL cholesterol. Mean CA-IMT was 0.62 ± 0.10 mm (0.40 - 0.98). CA-IMT was positively correlated with age, male gender and negatively with proteinuria and PON1 levels. In linear regression analysis, PON1 levels were associated with CA-IMT.
  
  
  CONCLUSIONS
  Reduced PON1 activity is significantly associated with increased carotid atherosclerosis in renal transplant patients.
authors.forename: Ozkan
authors.initials: O
authors.lastname: Gungor
authors.forename: Erkan
authors.initials: E
authors.lastname: Kismali
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Sisman
authors.forename: Fatih
authors.initials: F
authors.lastname: Kircelli
authors.forename: Gulay
authors.initials: G
authors.lastname: Asci
authors.forename: Kenan
authors.initials: K
authors.lastname: Topal
authors.forename: Savas
authors.initials: S
authors.lastname: Sipahi
authors.forename: Pinar
authors.initials: P
authors.lastname: Tuncel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozkahya
authors.forename: Huseyin
authors.initials: H
authors.lastname: Toz
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000201:enzymology / Q000209:etiology*; D059168:Carotid Intima-Media Thickness; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012307:Risk Factors; D013997:Time Factors; D018608:Ultrasonography, Doppler; D055815:Young Adult
chemical_list: D015415:Biomarkers; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human