title: Omega-3 fatty acid improves the clinical outcome of hepatectomized patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma.
abstract: Omega-3 fatty acid supplemented total parenteral nutrition improves the clinical outcome of patients undergoing certain operations; however, its benefits for patients with hepatitis type B virus (HBV)-associated hepatocellular carcinoma (HCC) who have undergone hepatectomy are still not clear. The aim of this study was to evaluate the effect of omega-3 fatty acid supplemented total parenteral nutrition on the clinical outcome of patients with HBV-associated HCC who underwent hepatectomy at our institution. A total of 63 patients with HBV-associated HCC who underwent hepatectomy were included in this study. These patients were randomly assigned to receive standard total parenteral nutrition (the control group, n = 31) or omega-3 fatty acid supplemented total parenteral nutrition (the omega-3 fatty acid group, n = 32) for at least 5 d. The study endpoints were the occurrence of infection-related complications, recovery of liver function and length of hospital stay. The results showed that the omega-3 fatty acid group had a lower infection rate (omega-3 fatty acid, 19.4% vs control, 43.8%, P < 0.05), a better liver function after hepatectomy: alanine transaminase (omega-3 fatty acid, 48.23±18.48 U/L vs control, 73.34±40.60 U/L, P < 0.01), aspartate transaminase (omega-3 fatty acid, 35.77±14.56 U/L vs control, 50.53±24.62 U/L, P < 0.01), total bilirubin (omega-3 fatty acid, 24.29±7.40 mmol/L vs control, 28. 37±8.06 mmol/L, P < 0.05) and a shorter length of hospital stay (omega-3 fatty acid, 12.71±2.58 d vs control, 15.91±3.23 d, P < 0.01). The serum contents of IL-6 (omega-3 fatty acid, 23.98±5.63 pg/mL vs control, 35.55±7.5 pg/mL, P < 0.01) and TNF-α (omega-3 fatty acid, 4.43±1.22 pg/mL vs control, 5.96±1.58 pg/mL, P < 0.01) after hepatectomy were significantly lower in the omega-3 fatty acid group than those of the control group. In conclusion, administration of omega-3 fatty acid may reduce infection rate and improve liver function recovery in HBV-associated HCC patients after hepatectomy. This improvement is associated with suppressed production of proinflammatory cytokines in these patients.
authors.affiliation: Liver Transplantation Center, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China; ; Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health, Nanjing, Jiangsu 210029, China.
authors.forename: Zhengshan
authors.initials: Z
authors.lastname: Wu
authors.forename: Jianjie
authors.initials: J
authors.lastname: Qin
authors.forename: Liyong
authors.initials: L
authors.lastname: Pu
keywords: hepatectomy; hepatocellular carcinoma; omega-3 fatty acids; total parenteral nutrition
references.citation: Lipids. 2004 Oct;39(10):963-76
references.pmid: 15691018
references.citation: Rev Invest Clin. 2005 May-Jun;57(3):457-72
references.pmid: 16187707
references.citation: Dig Liver Dis. 2011 Dec;43(12):984-90
references.pmid: 21840275
references.citation: JPEN J Parenter Enteral Nutr. 2005 Jul-Aug;29(4):236-40
references.pmid: 15961678
references.citation: Obes Rev. 2009 Nov;10(6):648-59
references.pmid: 19460115
references.citation: J Hepatol. 2007 Nov;47(5):718-25
references.pmid: 17869370
references.citation: Asian Pac J Cancer Prev. 2007 Jul-Sep;8(3):372-4
references.pmid: 18159970
references.citation: Lipids. 2000 Apr;35(4):445-52
references.pmid: 10858030
references.citation: Int J Cancer. 2004 Sep 10;111(4):611-6
references.pmid: 15239141
references.citation: Curr Opin Clin Nutr Metab Care. 2006 Mar;9(2):140-8
references.pmid: 16477179
references.citation: Clin Sci (Lond). 2004 Apr;106(4):359-64
references.pmid: 14624668
references.citation: J Med Assoc Thai. 2003 Jun;86(6):552-61
references.pmid: 12924804
references.citation: Am J Clin Nutr. 2005 Sep;82(3):668-74
references.pmid: 16155282
references.citation: Nutr Cancer. 1999;34(2):206-12
references.pmid: 10578489
references.citation: JPEN J Parenter Enteral Nutr. 2009 Jul-Aug;33(4):380-9
references.pmid: 19380752
references.citation: Biosci Biotechnol Biochem. 2005 Mar;69(3):483-90
references.pmid: 15784975
references.citation: Minerva Pediatr. 2009 Jun;61(3):263-72
references.pmid: 19461570
references.citation: Clin Chim Acta. 2006 Nov;373(1-2):1-8
references.pmid: 16796997
references.citation: Minerva Pediatr. 2008 Aug;60(4):443-55
references.pmid: 18511896