title: Two years efficiency of lamivudine and adefovir dipivoxil combined therapy in chronic hepatitis B patients.
abstract: BACKGROUND
  Lamivudine (LAM) and adefovir (ADV) are widely used in most Asian countries, though monotherapy is associated with the occurrence of resistance.
  
  
  OBJECTIVE
  To evaluate the efficiency of LAM and ADV combined treatment of chronic hepatitis B patients with compensated cirrhosis.
  
  
  METHODS
  206 eligible Chinese patients were randomly assigned in a 1:1 ratio to receive either LAM or ADV for the first 24 weeks. According to virologic response at 24 weeks, the patients either continued to monotherapy or switched to combined therapy for 48 weeks. After 48 weeks, all patients received LAM and ADV combined therapy for 96 weeks.
  
  
  RESULTS
  Serum HBV DNA levels significantly decreased in patients with ADV or LAM monotherapy and continuously reduced after the combined therapy. Serum ALT normalized rate were 88.24% and 81.37% at week 48, and 95.74% and 87.36% at week 96 in ADV and LAM group respectively, comparing to 60.78% and 56.73% in ADV and LAM groups at baseline. The accumulated virological breakthrough rate at week 48 and 96 was significantly higher in LAM group.
  
  
  CONCLUSIONS
  Both combination strategies were resulted in the long term virological, biochemical improvement in Chinese chronic hepatitis B patients with compensated cirrhosis.
authors.affiliation: Division of Gastroenterology and Hepatology, Jing'an District Central Hospital, Shanghai, China. hongwang905@163.com
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: Y Y
authors.initials: YY
authors.lastname: Ji
authors.forename: G B
authors.initials: GB
authors.lastname: Yao
authors.forename: X Y
authors.initials: XY
authors.lastname: Ma
authors.forename: Q
authors.initials: Q
authors.lastname: Xie
authors.forename: H Y
authors.initials: HY
authors.lastname: Pang
authors.forename: S M
authors.initials: SM
authors.lastname: Wu
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: C W
authors.initials: CW
authors.lastname: Chen
authors.forename: X W
authors.initials: XW
authors.lastname: Xu
authors.forename: E L
authors.initials: EL
authors.lastname: Gu
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004279:DNA, Viral / Q000097:blood; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008297:Male; D063065:Organophosphonates / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D063065:Organophosphonates; D019259:Lamivudine; D000225:Adenine; C106812:adefovir dipivoxil