title: Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology.
abstract: OBJECTIVE
  To establish evidence-based recommendations for the molecular analysis of lung cancers that are required to guide EGFR- and ALK-directed therapies, addressing which patients and samples should be tested, and when and how testing should be performed.
  
  
  METHODS
  Three cochairs without conflicts of interest were selected, one from each of the 3 sponsoring professional societies: College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. Writing and advisory panels were constituted from additional experts from these societies.
  
  
  METHODS
  Three unbiased literature searches of electronic databases were performed to capture articles published from January 2004 through February 2012, yielding 1533 articles whose abstracts were screened to identify 521 pertinent articles that were then reviewed in detail for their relevance to the recommendations. Evidence was formally graded for each recommendation.
  
  
  METHODS
  Initial recommendations were formulated by the cochairs and panel members at a public meeting. Each guideline section was assigned to at least 2 panelists. Drafts were circulated to the writing panel (version 1), advisory panel (version 2), and the public (version 3) before submission (version 4).
  
  
  CONCLUSIONS
  The 37 guideline items address 14 subjects, including 15 recommendations (evidence grade A/B). The major recommendations are to use testing for EGFR mutations and ALK fusions to guide patient selection for therapy with an epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) inhibitor, respectively, in all patients with advanced-stage adenocarcinoma, regardless of sex, race, smoking history, or other clinical risk factors, and to prioritize EGFR and ALK testing over other molecular predictive tests. As scientific discoveries and clinical practice outpace the completion of randomized clinical trials, evidence-based guidelines developed by expert practitioners are vital for communicating emerging clinical standards. Already, new treatments targeting genetic alterations in other, less common driver oncogenes are being evaluated in lung cancer, and testing for these may be addressed in future versions of these guidelines.
authors.affiliation: Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115-6110, USA. nlindeman@partners.org
authors.forename: Neal I
authors.initials: NI
authors.lastname: Lindeman
authors.forename: Philip T
authors.initials: PT
authors.lastname: Cagle
authors.forename: Mary Beth
authors.initials: MB
authors.lastname: Beasley
authors.forename: Dhananjay Arun
authors.initials: DA
authors.lastname: Chitale
authors.forename: Sanja
authors.initials: S
authors.lastname: Dacic
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Giaccone
authors.forename: Robert Brian
authors.initials: RB
authors.lastname: Jenkins
authors.forename: David J
authors.initials: DJ
authors.lastname: Kwiatkowski
authors.forename: Juan-Sebastian
authors.initials: JS
authors.lastname: Saldivar
authors.forename: Jeremy
authors.initials: J
authors.lastname: Squire
authors.forename: Erik
authors.initials: E
authors.lastname: Thunnissen
authors.forename: Marc
authors.initials: M
authors.lastname: Ladanyi
mesh_terms: D006801:Humans; D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D000077548:Anaplastic Lymphoma Kinase; D000970:Antineoplastic Agents / Q000627:therapeutic use; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics; D000069347:Erlotinib Hydrochloride; D000077156:Gefitinib; D005820:Genetic Testing; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D025202:Molecular Diagnostic Techniques / Q000379:methods; D058990:Molecular Targeted Therapy; D018579:Patient Selection; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics; D000078202:Systematic Reviews as Topic
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D000970:Antineoplastic Agents; C512478:EGFR protein, human; D066246:ErbB Receptors; D000069347:Erlotinib Hydrochloride; D000077156:Gefitinib; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D020794:Receptor Protein-Tyrosine Kinases
references.citation: Chest. 2007 Aug;132(2):597-602
references.pmid: 17573511
references.citation: J Thorac Oncol. 2011 Jan;6(1):21-7
references.pmid: 21107285
references.citation: N Engl J Med. 2009 Sep 3;361(10):947-57
references.pmid: 19692680
references.citation: Clin Cancer Res. 2010 Mar 1;16(5):1561-71
references.pmid: 20179225
references.citation: Lung Cancer. 2010 May;68(2):198-203
references.pmid: 19589612
references.citation: Clin Cancer Res. 2013 Feb 1;19(3):691-8
references.pmid: 23243218
references.citation: Arch Pathol Lab Med. 2012 Jan;136(1):41-6
references.pmid: 22208486
references.citation: Clin Cancer Res. 2012 Sep 15;18(18):4910-8
references.pmid: 22761469
references.citation: Br J Cancer. 2006 Oct 23;95(8):998-1004
references.pmid: 17047648
references.citation: J Clin Oncol. 2012 Apr 1;30(10):1122-8
references.pmid: 22370314
references.citation: N Engl J Med. 2005 Jul 14;353(2):123-32
references.pmid: 16014882
references.citation: Lung Cancer. 2012 Aug;77(2):299-305
references.pmid: 22542171
references.citation: Nat Med. 2012 Feb 12;18(3):378-81
references.pmid: 22327623
references.citation: J Thorac Oncol. 2012 Jun;7(6):1049-52
references.pmid: 22588155
references.citation: J Thorac Oncol. 2009 Jul;4(7):809-15
references.pmid: 19487967
references.citation: Virchows Arch. 2011 Jan;458(1):95-8
references.pmid: 21057810
references.citation: Neoplasia. 2008 Mar;10(3):298-302
references.pmid: 18320074
references.citation: Cancer Genet Cytogenet. 2007 Mar;173(2):107-13
references.pmid: 17321325
references.citation: Cancer Sci. 2008 Dec;99(12):2455-60
references.pmid: 18957054
references.citation: J Mol Diagn. 2010 Mar;12(2):169-76
references.pmid: 20093391
references.citation: Clin Cancer Res. 2005 Mar 15;11(6):2244-51
references.pmid: 15788673
references.citation: J Thorac Oncol. 2008 Aug;3(8):832-9
references.pmid: 18670300
references.citation: J Clin Oncol. 2009 Dec 20;27(36):6251-66
references.pmid: 19917871
references.citation: Oncologist. 2011;16(6):877-85
references.pmid: 21572125
references.citation: J Korean Med Sci. 2009 Jun;24(3):448-52
references.pmid: 19543508
references.citation: J Clin Oncol. 2010 Feb 20;28(6):918-27
references.pmid: 20100958
references.citation: Oncogene. 2011 Apr 14;30(15):1744-52
references.pmid: 21132006
references.citation: J Thorac Oncol. 2010 Nov;5(11):1734-40
references.pmid: 20881644
references.citation: J Exp Clin Cancer Res. 2011 Mar 17;30:30
references.pmid: 21414214
references.citation: Diagn Mol Pathol. 1995 Dec;4(4):249-55
references.pmid: 8634780
references.citation: Br J Cancer. 2007 Apr 23;96(8):1191-6
references.pmid: 17387341
references.citation: J Clin Oncol. 2005 Apr 10;23(11):2493-501
references.pmid: 15710947
references.citation: Genome Res. 2012 Mar;22(3):436-45
references.pmid: 22194472
references.citation: J Thorac Oncol. 2011 Aug;6(8):1359-66
references.pmid: 21587085
references.citation: Eur Respir J. 2011 Mar;37(3):624-31
references.pmid: 20595147
references.citation: Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):839-44
references.pmid: 16467097
references.citation: Clin Cancer Res. 2005 Apr 15;11(8):2924-9
references.pmid: 15837743
references.citation: Bratisl Lek Listy. 2010;111(7):365-8
references.pmid: 20806539
references.citation: J Clin Oncol. 2008 Feb 20;26(6):983-94
references.pmid: 18281673
references.citation: Lung Cancer. 2011 Jun;72(3):309-15
references.pmid: 21036415
references.citation: Cancer. 2009 Feb 25;117(1):67-72
references.pmid: 19347832
references.citation: J Clin Oncol. 2011 Aug 1;29(22):2972-7
references.pmid: 21730270
references.citation: J Thorac Oncol. 2007 Dec;2(12):1086-90
references.pmid: 18090579
references.citation: Lancet Oncol. 2011 Aug;12(8):795-805
references.pmid: 21782507
references.citation: Sci Transl Med. 2011 Jul 6;3(90):90ra59
references.pmid: 21734175
references.citation: Genet Med. 2011 Jul;13(7):667-75
references.pmid: 21738013
references.citation: Int J Cancer. 2008 Dec 1;123(11):2480-6
references.pmid: 18785203
references.citation: J Clin Oncol. 2008 Sep 10;26(26):4268-75
references.pmid: 18626007
references.citation: Br J Cancer. 2009 Feb 24;100(4):623-5
references.pmid: 19174819
references.citation: Cell Oncol. 2009;31(5):329-33
references.pmid: 19759413
references.citation: Genet Med. 2006 Jan;8(1):16-23
references.pmid: 16418595
references.citation: J Mol Diagn. 2006 Jul;8(3):335-41
references.pmid: 16825506
references.citation: Cell. 2007 Dec 14;131(6):1190-203
references.pmid: 18083107
references.citation: Am J Surg Pathol. 2006 Oct;30(10):1309-15
references.pmid: 17001163
references.citation: Diagn Mol Pathol. 2006 Jun;15(2):101-8
references.pmid: 16778591
references.citation: Cancer Res. 1992 May 1;52(9 Suppl):2702s-2706s
references.pmid: 1314134
references.citation: J Cancer Res Clin Oncol. 2010 Sep;136(9):1341-7
references.pmid: 20155428
references.citation: BMC Cancer. 2006 Dec 21;6:295
references.pmid: 17184525
references.citation: J Cancer Res Clin Oncol. 2009 Dec;135(12):1647-54
references.pmid: 19517135
references.citation: Clin Cancer Res. 2006 Jul 15;12(14 Pt 2):4372s-4376s
references.pmid: 16857813
references.citation: Br J Cancer. 2006 Oct 23;95(8):1070-5
references.pmid: 17047654
references.citation: J Clin Oncol. 2009 Nov 20;27(33):5620-6
references.pmid: 19786660
references.citation: Lung Cancer. 2012 Jan;75(1):82-8
references.pmid: 21684626
references.citation: J Exp Clin Cancer Res. 2011 May 16;30:57
references.pmid: 21575212
references.citation: J Clin Pathol. 2009 Dec;62(12):1096-102
references.pmid: 19640859
references.citation: Clin Cancer Res. 2008 Aug 1;14(15):4751-7
references.pmid: 18676744
references.citation: Clin Cancer Res. 2009 Aug 15;15(16):5267-73
references.pmid: 19671843
references.citation: Clin Cancer Res. 2011 Mar 1;17(5):1169-80
references.pmid: 21248300
references.citation: Clin Cancer Res. 2012 Mar 15;18(6):1790-7
references.pmid: 22190593
references.citation: Lung Cancer. 2006 Jan;51(1):71-7
references.pmid: 16198442
references.citation: Clin Cancer Res. 2007 May 15;13(10):2890-6
references.pmid: 17504988
references.citation: Br J Cancer. 2005 Aug 8;93(3):355-63
references.pmid: 16052218
references.citation: J Clin Oncol. 2008 Jun 1;26(16):2745-53
references.pmid: 18509184
references.citation: Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6816-22
references.pmid: 16203769
references.citation: Mol Cancer Ther. 2013 Feb;12(2):220-9
references.pmid: 23371856
references.citation: J Thorac Oncol. 2008 Feb;3(2):111-6
references.pmid: 18303429
references.citation: J Clin Oncol. 2010 Feb 10;28(5):744-52
references.pmid: 20038723
references.citation: Lung Cancer. 2011 Sep;73(3):316-9
references.pmid: 21315473
references.citation: J Clin Oncol. 2012 Mar 10;30(8):878-9
references.pmid: 22215755
references.citation: Anticancer Res. 2011 Oct;31(10):3457-62
references.pmid: 21965761
references.citation: PLoS One. 2012;7(2):e31323
references.pmid: 22347464
references.citation: Diagn Cytopathol. 2011 Sep;39(9):703-10
references.pmid: 21837660
references.citation: Acta Radiol. 2008 Nov;49(9):991-4
references.pmid: 18651255
references.citation: J Thorac Oncol. 2010 Dec;5(12):2039-40
references.pmid: 21102267
references.citation: J Clin Oncol. 2010 Jan 10;28(2):357-60
references.pmid: 19949011
references.citation: Br J Cancer. 2006 Dec 4;95(11):1483-9
references.pmid: 17106442
references.citation: N Engl J Med. 2012 Mar 8;366(10):883-892
references.pmid: 22397650
references.citation: Clin Chem. 2009 Apr;55(4):748-56
references.pmid: 19233916
references.citation: Cancer. 2007 May 1;109(9):1836-44
references.pmid: 17387741
references.citation: J Thorac Oncol. 2008 Jan;3(1):13-7
references.pmid: 18166835
references.citation: Mod Pathol. 2010 Feb;23(2):159-68
references.pmid: 19855375
references.citation: J Mol Diagn. 2008 May;10(3):242-8
references.pmid: 18403609
references.citation: N Engl J Med. 2010 Jun 24;362(25):2380-8
references.pmid: 20573926
references.citation: Lung Cancer. 2011 Feb;71(2):241-3
references.pmid: 21168933
references.citation: Hum Pathol. 2000 Nov;31(11):1414-9
references.pmid: 11112218
references.citation: Nat Biotechnol. 1999 Aug;17(8):804-7
references.pmid: 10429248
references.citation: Clin Cancer Res. 2008 Jul 1;14(13):4275-83
references.pmid: 18594010
references.citation: Diagn Pathol. 2009 Nov 04;4:36
references.pmid: 19889201
references.citation: Eur Respir J. 2012 Feb;39(2):366-72
references.pmid: 21778168
references.citation: Mod Pathol. 2011 Oct;24(10):1348-59
references.pmid: 21623384
references.citation: Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5385-90
references.pmid: 17875767
references.citation: J Thorac Oncol. 2010 Oct;5(10):1706-13
references.pmid: 20871269
references.citation: Arch Pathol Lab Med. 2012 Jan;136(1):33-40
references.pmid: 22208485
references.citation: Cancer Genet Cytogenet. 1998 Nov;107(1):21-7
references.pmid: 9809029
references.citation: BMC Med Res Methodol. 2011 Feb 28;11:23
references.pmid: 21356039
references.citation: J Clin Oncol. 2009 Mar 20;27(9):1394-400
references.pmid: 19224850
references.citation: J Thorac Oncol. 2011 Mar;6(3):627-30
references.pmid: 21317742
references.citation: Cancer Res. 2011 Sep 15;71(18):6051-60
references.pmid: 21791641
references.citation: Clin Cancer Res. 2006 Mar 1;12(5):1647-53
references.pmid: 16533793
references.citation: Cancer. 2006 Dec 15;107(12):2858-65
references.pmid: 17096434
references.citation: Arch Pathol Lab Med. 2012 Jan;136(1):11-3
references.pmid: 22208481
references.citation: Ann Oncol. 2006 Jun;17(6):1028-9
references.pmid: 16357019
references.citation: Biotechniques. 2002 Feb;32(2):296-8
references.pmid: 11848405
references.citation: J Mol Diagn. 2010 Jul;12(4):425-32
references.pmid: 20431034
references.citation: J Clin Oncol. 2009 Sep 10;27(26):4247-53
references.pmid: 19667264
references.citation: Lancet Oncol. 2011 Aug;12(8):710-1
references.pmid: 21783418
references.citation: Lung Cancer. 2005 Apr;48(1):141-4
references.pmid: 15777982
references.citation: J Clin Oncol. 2005 Oct 1;23(28):6829-37
references.pmid: 15998907
references.citation: Cancer. 2008 Dec 1;113(11):3199-208
references.pmid: 18932251
references.citation: J Mol Diagn. 2008 May;10(3):249-57
references.pmid: 18403606
references.citation: Cancer Cytopathol. 2011 Apr 25;119(2):80-91
references.pmid: 21400669
references.citation: Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11
references.pmid: 15329413
references.citation: Clin Lung Cancer. 2009 Jul;10(4):281-9
references.pmid: 19632948
references.citation: J Clin Oncol. 2011 Nov 1;29(31):4113-20
references.pmid: 21969500
references.citation: Cancer Res. 2006 Aug 15;66(16):7854-8
references.pmid: 16912157
references.citation: Appl Environ Microbiol. 1997 Oct;63(10):3741-51
references.pmid: 9327537
references.citation: Am J Pathol. 2002 Feb;160(2):449-57
references.pmid: 11839565
references.citation: Clin Cancer Res. 2005 Sep 15;11(18):6650-6
references.pmid: 16166444
references.citation: Lancet Oncol. 2011 Aug;12(8):735-42
references.pmid: 21783417
references.citation: Br J Cancer. 2004 Jul 19;91(2):355-8
references.pmid: 15188009
references.citation: J Thorac Oncol. 2010 Oct;5(10):1551-8
references.pmid: 20697298
references.citation: Am J Clin Pathol. 2011 Oct;136(4):564-71
references.pmid: 21917678
references.citation: Mod Pathol. 2013 Apr;26(4):511-22
references.pmid: 23196793
references.citation: J Thorac Oncol. 2010 Dec;5(12):1933-8
references.pmid: 20975603
references.citation: BMC Cancer. 2008 May 21;8:142
references.pmid: 18495026
references.citation: N Engl J Med. 2009 Sep 3;361(10):958-67
references.pmid: 19692684
references.citation: Nat Med. 2012 Feb 12;18(3):382-4
references.pmid: 22327622
references.citation: Jpn J Clin Oncol. 2006 Feb;36(2):69-75
references.pmid: 16449241
references.citation: Clin Cancer Res. 2012 Mar 1;18(5):1472-82
references.pmid: 22235099
references.citation: J Histochem Cytochem. 1985 Aug;33(8):845-53
references.pmid: 3894502
references.citation: Br J Cancer. 2006 Mar 27;94(6):896-903
references.pmid: 16552419
references.citation: Lancet Oncol. 2010 Feb;11(2):121-8
references.pmid: 20022809
references.citation: J Thorac Oncol. 2011 Mar;6(3):451-8
references.pmid: 21266922
references.citation: Lung Cancer. 2006 Sep;53(3):311-22
references.pmid: 16870303
references.citation: Lancet Oncol. 2012 Jan;13(1):e23-31
references.pmid: 21764376
references.citation: Int J Cancer. 2007 Sep 1;121(5):1162-7
references.pmid: 17487844
references.citation: PLoS One. 2011 Mar 08;6(3):e17791
references.pmid: 21408138
references.citation: BMC Med Res Methodol. 2009 Jun 11;9:34
references.pmid: 19519887
references.citation: J Clin Oncol. 2005 Nov 1;23(31):8081-92
references.pmid: 16204011
references.citation: Arch Pathol Lab Med. 2012 Jan;136(1):47-52
references.pmid: 22208487
references.citation: N Engl J Med. 2010 Oct 28;363(18):1734-9
references.pmid: 20979473
references.citation: Int J Clin Oncol. 2011 Aug;16(4):335-44
references.pmid: 21311943
references.citation: J Clin Oncol. 2007 Mar 1;25(7):760-6
references.pmid: 17228019
references.citation: Hum Pathol. 2009 Aug;40(8):1152-8
references.pmid: 19386350
references.citation: J Clin Oncol. 2009 Sep 10;27(26):4232-5
references.pmid: 19667260
references.citation: J Clin Pathol. 2011 Oct;64(10):884-92
references.pmid: 21947301
references.citation: Cancer Cytopathol. 2011 Apr 25;119(2):111-7
references.pmid: 21400670
references.citation: J Clin Oncol. 2004 Mar 15;22(6):1103-9
references.pmid: 15020612
references.citation: BMC Cancer. 2010 Jul 19;10:376
references.pmid: 20637128
references.citation: N Engl J Med. 2005 Feb 24;352(8):786-92
references.pmid: 15728811
references.citation: J Thorac Oncol. 2012 Dec;7(12):1815-1822
references.pmid: 23154553
references.citation: Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):751-8
references.pmid: 16467085
references.citation: Appl Immunohistochem Mol Morphol. 2008 Oct;16(5):485-92
references.pmid: 18594471
references.citation: Lung Cancer. 2012 Jun;76(3):403-9
references.pmid: 22129856
references.citation: Arch Pathol Lab Med. 2012 Jan;136(1):26-32
references.pmid: 22208484
references.citation: BMC Med Res Methodol. 2007 Feb 15;7:10
references.pmid: 17302989
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20932-7
references.pmid: 18093943
references.citation: Lung Cancer. 2007 Jun;56(3):383-9
references.pmid: 17368623
references.citation: Lung Cancer. 2011 Oct;74(1):35-40
references.pmid: 21444121
references.citation: Oncology. 2009;77 Suppl 1:90-6
references.pmid: 20130436
references.citation: Fed Regist. 1992 Feb 28;57(40):7002-186
references.pmid: 10170937
references.citation: Lancet. 2005 Oct 29-Nov 4;366(9496):1527-37
references.pmid: 16257339
references.citation: Chest. 2007 Jun;131(6):1628-34
references.pmid: 17565015
references.citation: J Clin Oncol. 2008 Mar 20;26(9):1472-8
references.pmid: 18349398
references.citation: Oncologist. 2007 Jan;12(1):90-8
references.pmid: 17285735
references.citation: J Clin Oncol. 2008 May 20;26(15):2442-9
references.pmid: 18458038
references.citation: Int J Oncol. 2001 May;18(5):1023-6
references.pmid: 11295051
references.citation: Lung Cancer. 2005 Dec;50(3):375-84
references.pmid: 16199108
references.citation: Diagn Cytopathol. 2013 Apr;41(4):316-23
references.pmid: 22102479
references.citation: J Clin Oncol. 2010 Oct 20;28(30):4616-20
references.pmid: 20855837
references.citation: Clin Cancer Res. 2012 Dec 15;18(24):6599-608
references.pmid: 23052255
references.citation: Clin Cancer Res. 2008 May 15;14(10):2895-9
references.pmid: 18483355
references.citation: Ann Oncol. 2007 Apr;18(4):752-60
references.pmid: 17317677
references.citation: Science. 2004 Jun 4;304(5676):1497-500
references.pmid: 15118125
references.citation: Clin Cancer Res. 2006 Nov 1;12(21):6494-501
references.pmid: 17085664
references.citation: Am J Clin Pathol. 2009 Apr;131(4):478-89
references.pmid: 19289583
references.citation: Ann Oncol. 2005 Jul;16(7):1081-6
references.pmid: 15851406
references.citation: J Thorac Oncol. 2011 Jan;6(1):28-31
references.pmid: 21107288
references.citation: Cancer Sci. 2007 Nov;98(11):1714-9
references.pmid: 17784875
references.citation: J Clin Oncol. 2005 Feb 1;23(4):857-65
references.pmid: 15681531
references.citation: Clin Cancer Res. 2008 Sep 15;14(18):5731-4
references.pmid: 18794081
references.citation: Mod Pathol. 2008 Sep;21(9):1168-75
references.pmid: 18587327
references.citation: Hum Pathol. 2006 Jun;37(6):755-63
references.pmid: 16733218
references.citation: Arch Pathol Lab Med. 2010 Jun;134(6):930-5
references.pmid: 20524870
references.citation: Clin Cancer Res. 2009 May 1;15(9):3023-8
references.pmid: 19366827
references.citation: Cancer. 2010 Sep 15;116(18):4309-17
references.pmid: 20549828
references.citation: J Clin Oncol. 2011 May 20;29(15):2121-7
references.pmid: 21482992
references.citation: Clin Cancer Res. 2009 May 15;15(10):3315-24
references.pmid: 19447869
references.citation: Ann Surg Oncol. 2010 Mar;17(3):889-97
references.pmid: 20183914
references.citation: Lung Cancer. 2005 Dec;50(3):385-91
references.pmid: 16140420
references.citation: Clin Cancer Res. 2005 Aug 15;11(16):5878-85
references.pmid: 16115929
references.citation: Cancer Res. 2009 Nov 1;69(21):8341-8
references.pmid: 19826035
references.citation: J Thorac Oncol. 2008 Oct;3(10):1096-103
references.pmid: 18827604
references.citation: Lung Cancer. 2011 Jul;73(1):45-50
references.pmid: 21129809
references.citation: Chest. 2010 Jan;137(1):46-52
references.pmid: 19376842
references.citation: Anticancer Res. 2009 Jul;29(7):2691-701
references.pmid: 19596948
references.citation: Virchows Arch. 2005 May;446(5):483-8
references.pmid: 15815931
references.citation: J Clin Oncol. 2011 Sep 10;29(26):3567-73
references.pmid: 21825259
references.citation: Lung Cancer. 2012 Apr;76(1):123-7
references.pmid: 22325357
references.citation: Clin Cancer Res. 2011 Dec 1;17(23):7394-401
references.pmid: 21948233
references.citation: Sci Transl Med. 2011 Nov 30;3(111):111ra121
references.pmid: 22133722
references.citation: PLoS One. 2011 May 05;6(5):e19601
references.pmid: 21573178
references.citation: Ann Oncol. 2007 Jan;18(1):99-103
references.pmid: 17060486
references.citation: J Clin Oncol. 2006 Jul 20;24(21):3340-6
references.pmid: 16785471
references.citation: Oncol Rep. 2011 Apr;25(4):921-8
references.pmid: 21318227
references.citation: Clin Cancer Res. 2004 Dec 15;10(24):8195-203
references.pmid: 15623594
references.citation: J Clin Oncol. 2006 Apr 10;24(11):1700-4
references.pmid: 16505411
references.citation: Onkologie. 2008 Apr;31(4):174-8
references.pmid: 18418018
references.citation: Nature. 2007 Aug 2;448(7153):561-6
references.pmid: 17625570
references.citation: J Thorac Oncol. 2008 May;3(5):472-6
references.pmid: 18448998
references.citation: J Mol Diagn. 2013 Mar;15(2):171-6
references.pmid: 23274167
references.citation: Lung Cancer. 2008 Jul;61(1):30-4
references.pmid: 18192072
references.citation: Clin Cancer Res. 2009 Aug 15;15(16):5216-23
references.pmid: 19671850
references.citation: J Cancer Res Clin Oncol. 2007 Feb;133(2):93-102
references.pmid: 16947044
references.citation: J Thorac Oncol. 2011 Feb;6(2):244-85
references.pmid: 21252716
references.citation: Cell Res. 2005 Mar;15(3):212-7
references.pmid: 15780185
references.citation: Cancer Res. 2004 Dec 15;64(24):8919-23
references.pmid: 15604253
references.citation: Cancer Res. 2010 Dec 15;70(24):10038-43
references.pmid: 21030459
references.citation: Clin Cancer Res. 2010 Nov 15;16(22):5581-90
references.pmid: 21062932
references.citation: Sci Transl Med. 2011 Mar 23;3(75):75ra26
references.pmid: 21430269
references.citation: Nucleic Acids Res. 1989 Apr 11;17(7):2503-16
references.pmid: 2785681
references.citation: J Clin Oncol. 2005 Oct 1;23(28):6838-45
references.pmid: 15998906
references.citation: Mol Cancer. 2010 Jul 13;9:188
references.pmid: 20624322
references.citation: Arch Pathol Lab Med. 2007;131(1):18-43
references.pmid: 19548375
references.citation: Oncologist. 2008 Sep;13(9):933-44
references.pmid: 18784157
references.citation: Int J Cancer. 2007 Mar 15;120(6):1239-47
references.pmid: 17192902
references.citation: J Clin Oncol. 2007 Jun 1;25(16):2248-55
references.pmid: 17538169
references.citation: J Thorac Oncol. 2006 Mar;1(3):231-9
references.pmid: 17409862
references.citation: PLoS One. 2011;6(9):e25191
references.pmid: 21949883
references.citation: J Clin Microbiol. 1992 Dec;30(12):3095-8
references.pmid: 1452690
references.citation: J Thorac Oncol. 2006 Sep;1(7):629-34
references.pmid: 17409929
references.citation: J Thorac Oncol. 2012 Feb;7(2):340-7
references.pmid: 22237262
references.citation: Clin Cancer Res. 2011 Jun 1;17(11):3542-50
references.pmid: 21521776
references.citation: J Mol Diagn. 2010 Mar;12(2):257-64
references.pmid: 20093389
references.citation: Lung Cancer. 2001 Feb-Mar;31(2-3):267-70
references.pmid: 11165406
references.citation: J Thorac Oncol. 2011 Jan;6(1):139-47
references.pmid: 21107284
references.citation: J Thorac Oncol. 2011 Apr;6(4):707-15
references.pmid: 21258250
references.citation: Am J Pathol. 1998 Aug;153(2):373-9
references.pmid: 9708798
references.citation: J Mol Diagn. 2008 Mar;10(2):160-8
references.pmid: 18258923
references.citation: Lung Cancer. 2007 Dec;58(3):411-3
references.pmid: 17601631
references.citation: N Engl J Med. 2006 Jul 13;355(2):213-5
references.pmid: 16837691
references.citation: J Clin Oncol. 2009 Dec 20;27(36):6229-36
references.pmid: 19884551
references.citation: N Engl J Med. 2005 Jul 14;353(2):133-44
references.pmid: 16014883
references.citation: Cancer Discov. 2012 Oct;2(10):922-33
references.pmid: 22956644
references.citation: J Thorac Oncol. 2011 Mar;6(3):466-72
references.pmid: 21258247
references.citation: Cancer Chemother Pharmacol. 2011 Jan;67(1):35-9
references.pmid: 20182725
references.citation: Onkologie. 2010;33(5):231-8
references.pmid: 20502057
references.citation: Clin Cancer Res. 2008 Oct 1;14(19):6092-6
references.pmid: 18829487
references.citation: Science. 2007 May 18;316(5827):1039-43
references.pmid: 17463250
references.citation: Mod Pathol. 2009 Apr;22(4):508-15
references.pmid: 19234440
references.citation: Cancer. 2007 Feb 1;109(3):581-7
references.pmid: 17186532
references.citation: Nature. 2012 Sep 27;489(7417):519-25
references.pmid: 22960745
references.citation: PLoS Med. 2005 Mar;2(3):e73
references.pmid: 15737014
references.citation: J Cancer Res Clin Oncol. 2008 May;134(5):569-77
references.pmid: 17932690
references.citation: Lung Cancer. 2010 Mar;67(3):355-60
references.pmid: 19473722
references.citation: Lung Cancer. 2009 Jun;64(3):314-8
references.pmid: 18992959
references.citation: Am J Clin Pathol. 2010 Jun;133(6):922-34
references.pmid: 20472851
references.citation: J Mol Diagn. 2011 Jan;13(1):74-84
references.pmid: 21227397
references.citation: Lung Cancer. 2008 Aug;61(2):163-9
references.pmid: 18242762
references.citation: Clin Cancer Res. 2012 Nov 15;18(22):6169-77
references.pmid: 23014527
references.citation: J Natl Cancer Inst. 2005 Mar 2;97(5):339-46
references.pmid: 15741570
references.citation: Nat Med. 2012 Feb 12;18(3):375-7
references.pmid: 22327624
references.citation: J Thorac Oncol. 2011 Mar;6(3):459-65
references.pmid: 21278610
references.citation: Clin Cancer Res. 2009 May 1;15(9):3143-9
references.pmid: 19383809
references.citation: N Engl J Med. 2004 May 20;350(21):2129-39
references.pmid: 15118073
references.citation: Clin Cancer Res. 2008 Jun 15;14(12):3860-6
references.pmid: 18559606
references.citation: Clin Cancer Res. 2008 Oct 15;14(20):6618-24
references.pmid: 18927303
references.citation: Clin Cancer Res. 2012 Feb 15;18(4):1167-76
references.pmid: 22228640
references.citation: Lancet Oncol. 2011 Oct;12(11):1004-12
references.pmid: 21933749
references.citation: Clin Cancer Res. 2007 Sep 1;13(17):4974-83
references.pmid: 17785547
references.citation: Am J Pathol. 1999 Nov;155(5):1467-71
references.pmid: 10550302
references.citation: Pathol Oncol Res. 2008 Dec;14(4):373-9
references.pmid: 18985444
references.citation: Lancet Oncol. 2012 Mar;13(3):239-46
references.pmid: 22285168
references.citation: J Cancer Res Clin Oncol. 2009 Jun;135(6):771-82
references.pmid: 19020901
references.citation: Sci Transl Med. 2012 Feb 8;4(120):120ra17
references.pmid: 22277784
references.citation: N Engl J Med. 2010 Oct 28;363(18):1693-703
references.pmid: 20979469
references.citation: PLoS One. 2009 Oct 14;4(10):e7464
references.pmid: 19826477
references.citation: Anticancer Res. 2008 Jul-Aug;28(4B):2265-70
references.pmid: 18751405
references.citation: J Thorac Oncol. 2012 Feb;7(2):459-67
references.pmid: 22237263
references.citation: J Mol Diagn. 2005 Feb;7(1):36-9
references.pmid: 15681472
references.citation: J Thorac Oncol. 2007 Jul;2(7):632-7
references.pmid: 17607119
references.citation: Clin Cancer Res. 2011 May 15;17(10):3500-6
references.pmid: 21558399
references.citation: J Clin Oncol. 2011 Jul 20;29(21):2866-74
references.pmid: 21670455
references.citation: J Natl Cancer Inst. 2005 May 4;97(9):643-55
references.pmid: 15870435
references.citation: Cancer Prev Res (Phila). 2008 Aug;1(3):192-200
references.pmid: 19138956
references.citation: Oncol Rep. 2006 Sep;16(3):533-41
references.pmid: 16865253
references.citation: Clin Cancer Res. 2005 May 15;11(10):3750-7
references.pmid: 15897572
references.citation: Cancer Sci. 2008 Mar;99(3):595-600
references.pmid: 18271876
references.citation: J Clin Invest. 2006 Oct;116(10):2695-706
references.pmid: 16906227
references.citation: Clin Cancer Res. 2010 Jun 15;16(12):3163-70
references.pmid: 20423982
references.citation: J Mol Diagn. 2005 Aug;7(3):396-403
references.pmid: 16049312
references.citation: Clin Cancer Res. 2005 Feb 1;11(3):1167-73
references.pmid: 15709185
references.citation: Am J Pathol. 2002 Dec;161(6):1961-71
references.pmid: 12466110
references.citation: J Thorac Oncol. 2006 Oct;1(8):787-95
references.pmid: 17409961
references.citation: J Thorac Oncol. 2006 Jan;1(1):52-60
references.pmid: 17409827
references.citation: Int J Cancer. 2006 Nov 15;119(10):2353-8
references.pmid: 16921488
references.citation: Mol Diagn Ther. 2011 Feb 1;15(1):21-9
references.pmid: 21469767
references.citation: PLoS One. 2012;7(3):e33003
references.pmid: 22412972
references.citation: J Thorac Oncol. 2012 Apr;7(4):768-9
references.pmid: 22425930
references.citation: Medicine (Baltimore). 2011 May;90(3):159-167
references.pmid: 21512416
references.citation: Clin Cancer Res. 2006 Jul 1;12(13):3915-21
references.pmid: 16818687
references.citation: J Thorac Oncol. 2008 Nov;3(11):1224-35
references.pmid: 18978556
references.citation: Clin Cancer Res. 2009 Apr 15;15(8):2630-6
references.pmid: 19351754