title: Anatomical segregation of visual selection mechanisms in human parietal cortex.
abstract: Visual selection requires mechanisms for representing object salience and for shifting the focus of processing to novel objects. It is not clear from computational or neural models whether these operations are performed within the same or different brain regions. Here, we use repetitive transcranial magnetic stimulation to briefly interfere with neural activity in individually localized regions of human posterior parietal cortex (PPC) that are putatively involved in attending to contralateral locations or shifting attention between locations. Stimulation over right ventral intraparietal sulcus impaired target discrimination at contralateral locations, whereas stimulation over right medial superior parietal lobule impaired target discrimination after a shift of attention regardless of its location. This double dissociation is consistent with neuroimaging studies and indicates that mechanisms of visual selection are partly anatomically segregated in human PPC.
authors.affiliation: Department of Neuroscience and Imaging and Institute of Advanced Biomedical Technologies, Gabriele D'Annunzio University, I-66110 Chieti, Italy. pcapotosto@unich.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Capotosto
authors.forename: Annalisa
authors.initials: A
authors.lastname: Tosoni
authors.forename: Sara
authors.initials: S
authors.lastname: Spadone
authors.forename: Carlo
authors.initials: C
authors.lastname: Sestieri
authors.forename: Mauro Gianni
authors.initials: MG
authors.lastname: Perrucci
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Romani
authors.forename: Stefania
authors.initials: S
authors.lastname: Della Penna
authors.forename: Maurizio
authors.initials: M
authors.lastname: Corbetta
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D002755:Choice Behavior / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009949:Orientation / Q000502:physiology; D010100:Oxygen / Q000097:blood; D010296:Parietal Lobe / Q000098:blood supply / Q000502:physiology*; D010775:Photic Stimulation; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult
chemical_list: D010100:Oxygen
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