title: The role of the vessel wall.
abstract: The role of the vessel wall is complex and its effects are wide-ranging. The vessel wall, specifically the endothelial monolayer that lines the inner lumen, possesses the ability to influence various physiological states both locally and systemically by controlling vascular tone, basement membrane component synthesis, angiogenesis, haemostatic properties, and immunogenicity. This is an overview of the function and structure of the vessel wall and how disruption and dysfunction in any of these regulatory roles can lead to disease states.
authors.affiliation: Thrombosis and Atherosclerosis Research Institute (TaARI), McMaster University, Hamilton, ON, Canada.
authors.forename: Nethnapha
authors.initials: N
authors.lastname: Paredes
authors.forename: Anthony K C
authors.initials: AK
authors.lastname: Chan
mesh_terms: D001485:Basement Membrane / Q000502:physiology; D042783:Endothelial Cells; D004730:Endothelium, Vascular / Q000502:physiology*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D018919:Neovascularization, Physiologic; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology