title: Dynamics of oxidative stress and urinary excretion of melatonin and its metabolites during acute ischemic stroke.
abstract: Oxidative stress is a leading cause of neuronal damage in ischemic stroke. Melatonin may play a role in the antioxidant response. Melatonin and its metabolites may be involved in the modulation of oxidative stress in human acute stroke. No data are available in humans to establish this relationship. In this context, on the first and the fifth days post-stroke, we assessed serum total antioxidant capacity (TAC) and urine levels of melatonin, 6-sulfatoxymelatonin (aMT6S), and N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), the last compound being produced in the brain after reaction of melatonin with reactive oxygen species. Compared to controls' values, TAC and levels of melatonin and aMT6S were reduced, without difference between the first and the fifth days post-stroke, whereas AFMK levels remained in the normal range at both time points. Melatonin catabolism might be speeded up in acute ischemic stroke in order to increase the antioxidant response.
authors.affiliation: Cerebrovascular Unit, Neurology Department, Pierre Wertheimer Hospital, 59 Boulevard Pinel, 69677 Bron, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ritzenthaler
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lhommeau
authors.forename: Samuel
authors.initials: S
authors.lastname: Douillard
authors.forename: Tea Hee
authors.initials: TH
authors.lastname: Cho
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Brun
authors.forename: Thierry
authors.initials: T
authors.lastname: Patrice
authors.forename: Norbert
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: Bruno
authors.initials: B
authors.lastname: Claustrat
mesh_terms: D000368:Aged; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007511:Ischemia / Q000453:epidemiology* / Q000652:urine*; D008297:Male; D008550:Melatonin / Q000652:urine*; D008660:Metabolism; D008875:Middle Aged; D018384:Oxidative Stress; D015995:Prevalence; D017382:Reactive Oxygen Species / Q000652:urine*; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000652:urine*
chemical_list: D017382:Reactive Oxygen Species; D008550:Melatonin