title: Collagen-hydroxyapatite/cisplatin drug delivery systems for locoregional treatment of bone cancer.
abstract: In this paper, the synthesis and characterization of novel cisplatin-loaded collagen (COLL)/hydroxyapatite (HA) composite materials are presented. The composite materials were designed to obtain a COLL: HA weight ratio close to the bone composition. The content of embedded cisplatin was chosen to assure a concentration of cisplatin of 6 and 10 μM, respectively, into the culture media used in cell culture experiments. These cisplatin delivery systems were characterized by determining the physico-chemical properties of the composite material, the drug release process as well as their biological activity. Based on the in vitro data that showed the cytotoxic, anti-proliferative and anti-invasive activities of these multifunctional systems on G292 osteosarcoma cells in dependence on the cisplatin concentration released in culture medium, we conclude that the newly developed COLL/HA-cisplatin drug delivery system could be a feasible approach for locoregional chemotherapy of bone cancer.
authors.affiliation: Politechnica University of Bucharest, Faculty of Applied Chemistry and Material Science, 1-7 Polizu Str., 011061 Bucharest, Romania. e_andronescu@rectorat.pub.ro.
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Andronescu
authors.forename: Anton
authors.initials: A
authors.lastname: Ficai
authors.forename: Madalina Georgiana
authors.initials: MG
authors.lastname: Albu
authors.forename: Valentina
authors.initials: V
authors.lastname: Mitran
authors.forename: Maria
authors.initials: M
authors.lastname: Sonmez
authors.forename: Denisa
authors.initials: D
authors.lastname: Ficai
authors.forename: Raluca
authors.initials: R
authors.lastname: Ion
authors.forename: Anisoara
authors.initials: A
authors.lastname: Cimpean
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D017886:Durapatite / Q000008:administration & dosage*; D006801:Humans; D016062:Porosity; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D018809:Proliferating Cell Nuclear Antigen; D003094:Collagen; D017886:Durapatite; D002945:Cisplatin