title: Spatial-temporal variations of Schistosoma japonicum distribution after an integrated national control strategy: a cohort in a marshland area of China.
abstract: BACKGROUND
  Schistosomiasis transmission is typically focal. Understanding spatial variations of Schistosoma infections and their associated factors is important to help to invent site-specific intervention strategies.
  
  
  METHODS
  A five-year longitudinal study was carried out prospectively in 12 natural villages, Guichi district of Anhui province. A GIS-based spatial analysis was conducted to identify geographic distribution patterns of schistosomiasis infections at the household scale.
  
  
  RESULTS
  The results of the spatial autocorrelation analysis for 2005 showed that there were significant spatial clusters of human infections at the household level, and these results were in agreement with that of the spatial scan statistic. As prevalence of infections in humans decreased over the course of control, the spatial distribution of these infections became less heterogeneous.
  
  
  CONCLUSIONS
  The findings imply that it may be necessary to re-assess risk factors of S. japonicum transmission over the course of control and to adjust accordingly control measures in the communities.
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China. ybzhou@fudan.edu.cn
authors.forename: Yi-Biao
authors.initials: YB
authors.lastname: Zhou
authors.forename: Song
authors.initials: S
authors.lastname: Liang
authors.forename: Geng-Xin
authors.initials: GX
authors.lastname: Chen
authors.forename: Chris
authors.initials: C
authors.lastname: Rea
authors.forename: Shi-Min
authors.initials: SM
authors.lastname: Han
authors.forename: Zong-Gui
authors.initials: ZG
authors.lastname: He
authors.forename: Yuan-Pei
authors.initials: YP
authors.lastname: Li
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Wei
authors.forename: Gen-Ming
authors.initials: GM
authors.lastname: Zhao
authors.forename: Qing-Wu
authors.initials: QW
authors.lastname: Jiang
mesh_terms: D000368:Aged; D000818:Animals; D002648:Child; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D015331:Cohort Studies; D003710:Demography / Q000706:statistics & numerical data / Q000639:trends; D004785:Environmental Pollutants / Q000009:adverse effects; D040362:Geographic Information Systems; D006801:Humans; D017053:Infection Control / Q000379:methods*; D008137:Longitudinal Studies; D008875:Middle Aged; D011159:Population Surveillance; D012111:Residence Characteristics / Q000706:statistics & numerical data; D012307:Risk Factors; D012549:Schistosoma japonicum / Q000302:isolation & purification*; D012552:Schistosomiasis / Q000453:epidemiology* / Q000469:parasitology / Q000517:prevention & control / Q000635:transmission; D062211:Spatio-Temporal Analysis; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants
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