title: A potential rhodium cancer therapy: studies of a cytotoxic organorhodium(I) complex that binds DNA.
abstract: Described is a novel organorhodium(I) complex that is cytotoxic to the colon cancer cell line HCT116 and alters cell migration, DNA replication, and DNA condensation. Most importantly, the mechanism observed is not seen for the parent organorhodium dimer complex [{RhCl(COD)}2], RhCl3, or the free ligand/proligands (COD and 1-(n)butyl-3-methylimidazolium chloride). Thus, the activity of this organorhodium complex is attributable to its unique structure.
authors.affiliation: Department of Chemistry, University of New South Wales, Kensington, NSW 2052, Australia.
authors.forename: Jeanette R
authors.initials: JR
authors.lastname: McConnell
authors.forename: Dimple P
authors.initials: DP
authors.lastname: Rananaware
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Ramsey
authors.forename: Kai N
authors.initials: KN
authors.lastname: Buys
authors.forename: Marcus L
authors.initials: ML
authors.lastname: Cole
authors.forename: Shelli R
authors.initials: SR
authors.lastname: McAlpine
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry / Q000633:toxicity; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004261:DNA Replication / Q000187:drug effects; D059585:G1 Phase Cell Cycle Checkpoints / Q000187:drug effects; D045325:HCT116 Cells; D006801:Humans; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D004247:DNA; D012238:Rhodium; D002945:Cisplatin
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