title: Aryl hydrocarbon receptor and lung cancer.
abstract: The leading cause of lung cancer is exposure to cigarette smoke and other environmental pollutants, which include formaldehyde, acrolein, benzene, dioxin, and polycyclic aromatic hydrocarbons (PAHs). PAHs and dioxins are exogenous ligands that directly bind to the aryl hydrocarbon receptor (AhR), a transcription factor that activates xenobiotic metabolism, histone modification (an important step in DNA methylation) and, ultimately, tumorigenesis. In this review article we summarize the current understanding of AhR and its role in the development of lung cancer, including its influence on cell proliferation, angiogenesis, inflammation, and apoptosis.
authors.affiliation: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY, USA. tsayj01@nyumc.org
authors.forename: Junchieh J
authors.initials: JJ
authors.lastname: Tsay
authors.forename: Kam-Meng
authors.initials: KM
authors.lastname: Tchou-Wong
authors.forename: Alissa K
authors.initials: AK
authors.lastname: Greenberg
authors.forename: Harvey
authors.initials: H
authors.lastname: Pass
authors.forename: William N
authors.initials: WN
authors.lastname: Rom
mesh_terms: D000818:Animals; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism*
chemical_list: D018336:Receptors, Aryl Hydrocarbon
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