title: Photoactivation of (p-methoxyphenyl)(trifluoromethyl)diazirine in the presence of phenolic reaction partners.
abstract: Shine light on your chemistry! Irradiating 3-(4-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine in the presence of equimolar solutions of phenol and tyrosine derivatives leads to Friedel-Crafts alkylations (see scheme), which suggests a strategy for the development of "cleaner" diazirines for chemical biology.
authors.affiliation: TU Braunschweig, Institute of Organic Chemistry, Hagenring 30, 38106 Braunschweig, Germany.
authors.forename: Björn
authors.initials: B
authors.lastname: Raimer
authors.forename: Thomas
authors.initials: T
authors.lastname: Lindel
mesh_terms: D000478:Alkylation; D001389:Azirines; D002384:Catalysis; D003978:Diazomethane / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000528:radiation effects; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D055668:Photochemical Processes; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: C585163:3-(4-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine; D001389:Azirines; D010636:Phenols; D014443:Tyrosine; D003978:Diazomethane