title: Biology of chronic lymphocytic leukemia in different microenvironments: clinical and therapeutic implications.
abstract: Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature monoclonal B cells in peripheral blood, bone marrow, spleen, and lymph nodes. The trafficking, survival, and proliferation of CLL cells is tightly regulated by the surrounding tissue microenvironment and is mediated by antigenic stimulation, close interaction with various accessory cells and exposure to different cytokines, chemokines, and extracellular matrix components. In the last decade there have been major advances in the understanding of the reciprocal interactions between CLL cells and the various microenvironmental compartments. This article discusses the role of the microenvironment in the context of efforts to develop novel therapeutics that target the biology of CLL.
authors.affiliation: Hematology Institute, Tel-Aviv Sourasky Medical Center, Tel-Aviv 64239, Israel.
authors.forename: Yair
authors.initials: Y
authors.lastname: Herishanu
authors.forename: Ben-Zion
authors.initials: BZ
authors.lastname: Katz
authors.forename: Andrew
authors.initials: A
authors.lastname: Lipsky
authors.forename: Adrian
authors.initials: A
authors.lastname: Wiestner
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002450:Cell Communication / Q000187:drug effects; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000209:etiology*; D015398:Signal Transduction / Q000187:drug effects; D059016:Tumor Microenvironment / Q000187:drug effects / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents
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