title: Paternal fenvalerate exposure influences reproductive functions in the offspring.
abstract: Fenvalerate (Fen), a synthetic pyrethroid insecticide, has been shown to have adverse effects on male reproductive system. Thus, the aim of the present study was to elucidate whether these adverse effects are passed from exposed male mice to their offspring. Adult male mice received Fen (10 mg/kg) daily for 30 days and mated with untreated females to produce offspring. Fenvalerate significantly changed the methylation status of angiotensin I-converting enzyme (Ace), forkhead box O3 (Foxo3a), huntingtin-associated protein 1 (Hap1), nuclear receptor subfamily 3 (Nr3c2), promyelocytic leukemia (Pml), and Prostaglandin F2 receptor negative regulator (Ptgfrn) genes in paternal mice sperm genomic DNA. Further, Fen significantly increased sperm abnormalities; serum testosterone and estradiol-17ß level in adult male (F0) and their male offspring (F1). Further, paternal Fen treatment significantly increased the length of estrous cycle, serum estradiol-17ß concentration in estrus, and progesterone levels in diestrus in female offspring (F1). These findings suggest that adverse effects of paternal Fen exposure on reproductive functions can be seen not only in treated males (F0) but also in their offsprings.
authors.affiliation: 1Institute of Animal Husbandry & Veterinary Sciences, Shanghai Academy of Agricultural Sciences, Shanghai, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xia
authors.forename: Nahid
authors.initials: N
authors.lastname: Parvizi
authors.forename: Yuchuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Kesi
authors.initials: K
authors.lastname: Xu
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.forename: Rongjie
authors.initials: R
authors.lastname: Li
authors.forename: Yiqiong
authors.initials: Y
authors.lastname: Hang
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000818:Animals; D019175:DNA Methylation / Q000187:drug effects; D044127:Epigenesis, Genetic / Q000187:drug effects; D004958:Estradiol / Q000097:blood; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D009570:Nitriles / Q000633:toxicity*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D018812:Paternal Exposure / Q000009:adverse effects*; D011374:Progesterone / Q000097:blood; D011722:Pyrethrins / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects* / Q000235:genetics; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology; D013737:Testis / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000097:blood; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; C017690:fenvalerate
keywords: fenvalerate; intergenerational action; methylation; mice; reproductive function
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