title: The HLA Class II Associations with Rheumatic Heart Disease in South Indian Patients: A Preliminary Study.
abstract: BACKGROUND
  Rheumatic heart disease (RHD) occurs in 30-45% of the patients with rheumatic fever (RF) and it leads to chronic valvular lesions. The human leukocyte antigen (HLA) might confer a susceptibility to RHD. The aim of the present study was to determine the prevalent HLA class II DR/DQ allelic types which were associated with rheumatic heart disease (RHD) in a small group of south Indian patients and to compare them with those in the control subjects.
  
  
  METHODS
  A total of 23 patients who were diagnosed with RHD and 6 control samples were included in this study. A low resolution HLA Class II DR/DQ typing was performed on the blood samples by the PCR-SSP method.
  
  
  CONCLUSIONS
  The DRB3*01:01:02:01 allele showed a positive association with RHD, whereas the DQB1 loci alleles did not show any significant association.
authors.affiliation: PhD Research Scholar, Department of Microbiology, Dr.A.L.Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras , Taramani, Chennai-600113, India .
authors.forename: Divya
authors.initials: D
authors.lastname: Bajoria
authors.forename: Thangam
authors.initials: T
authors.lastname: Menon
keywords: HLA Class II DR/DQ typing; Rheumatic Heart Disease; South India
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