title: Type 2 diabetes and risk of rupture of saccular intracranial aneurysm in eastern Finland.
abstract: OBJECTIVE
  Type 2 diabetes is a risk factor for other forms of stroke, but its association with subarachnoid hemorrhage (SAH) from ruptured saccular intracranial aneurysm (sIA) has remained unclear.
  
  
  METHODS
  Kuopio Intracranial Aneurysm Database (www.uef.fi/ns) includes all ruptured and unruptured sIA cases from a defined catchment population in eastern Finland since 1980. We compared the age-adjusted incidences of type 2 diabetes in 1,058 ruptured and 484 unruptured sIA patients during 1994-2008, using the national registry of prescribed medicine purchases.
  
  
  RESULTS
  Of the 1,058 ruptured sIA patients, 43% were males and 57% females, with a median age at rupture of 51 and 56 years, respectively. From 1994 to 2008 or until death, 9% had been prescribed antidiabetes medication (ADM) with a median starting age of 58 years for males and 66 years for females. Of the 484 unruptured sIA patients, 44% were males and 56% females, with a median age at the diagnosis of 53 and 55 years, respectively, and 9% had used ADM, with a median starting age of 61 years for males and 66 years for females. The incidence of type 2 diabetes was highest in the age-group 60-70 years, with no significant differences between the ruptured and unruptured sIA patients.
  
  
  CONCLUSIONS
  Our study suggests that type 2 diabetes does not increase the risk of rupture of sIA, which is by far the most frequent cause of nontraumatic SAH.
authors.affiliation: Neurosurgery, NeuroCenter, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Antti E
authors.initials: AE
authors.lastname: Lindgren
authors.forename: Mitja I
authors.initials: MI
authors.lastname: Kurki
authors.forename: Annamaija
authors.initials: A
authors.lastname: Riihinen
authors.forename: Timo
authors.initials: T
authors.lastname: Koivisto
authors.forename: Antti
authors.initials: A
authors.lastname: Ronkainen
authors.forename: Jaakko
authors.initials: J
authors.lastname: Rinne
authors.forename: Juha
authors.initials: J
authors.lastname: Hernesniemi
authors.forename: Johan G
authors.initials: JG
authors.lastname: Eriksson
authors.forename: Juha E
authors.initials: JE
authors.lastname: Jääskeläinen
authors.forename: Mikael
authors.initials: M
authors.lastname: von und zu Fraunberg
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005387:Finland / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D002532:Intracranial Aneurysm / Q000453:epidemiology*; D008875:Middle Aged; D012307:Risk Factors
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