title: Characterization of Tat antibody responses in Chinese individuals infected with HIV-1.
abstract: HIV-1 Tat is an important regulatory protein involved in AIDS pathogenesis. However, the immunoprofiles of anti-Tat responses remain unclear. We analysed the immunoprofiles of the anti-Tat antibody responses and the neutralizing activities. Out of 326 HIV-1-seropositive individuals, 12.9% were positive for anti-Tat antibodies. We found six different immunological profiles of anti-Tat antibody responses: full-potential response, combined response, N-specific response, C-specific response, full-length Tat-specific response and Tat-related response. These responses represent two types of anti-Tat responses: the major complete response and the alternative C-prone response. A Tat-neutralizing activity is significantly higher in anti-Tat-seropositive samples than anti-Tat-negative or healthy blood-donor samples, and significantly correlates with the anti-Tat reactivities. The data here could contribute to a better understanding of the significance of anti-Tat responses in preventing HIV pathogenesis and could be useful for designing more effective vaccines in the future.
authors.affiliation: Department of Microbiology, Second Military Medical University, Shanghai, China.
authors.forename: Qiuli
authors.initials: Q
authors.lastname: Chen
authors.forename: Lan
authors.initials: L
authors.lastname: Li
authors.forename: Wenting
authors.initials: W
authors.lastname: Liao
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.forename: Jinhong
authors.initials: J
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Sheng
authors.forename: Huaqun
authors.initials: H
authors.lastname: Zhang
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Huang
authors.forename: Yingying
authors.initials: Y
authors.lastname: Ding
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
mesh_terms: D000328:Adult; D000917:Antibody Formation / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015696:Gene Products, tat / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology; D015497:HIV-1 / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D008297:Male
chemical_list: D015696:Gene Products, tat
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