title: Current perspectives of nanoparticles in medical and dental biomaterials.
abstract: Nanotechnology is gaining tremendous impetus due to its capability of modulating metals into their nanosize, which drastically changes the chemical, physical and optical properties of metals. Nanoparticles have been introduced as materials with good potential to be extensively used in biological and medical applications. Nanoparticles are clusters of atoms in the size range of 1-100 nm. Inorganic nanoparticles and their nano-composites are applied as good antibacterial agents. Due to the outbreak of infectious diseases caused by different pathogenic bacteria and the development of antibiotic resistance, pharmaceutical companies and researchers are searching for new antibacterial agents. The metallic nanoparticles are the most promising as they show good antibacterial properties due to their large surface area to volume ratios, which draw growing interest from researchers due to increasing microbial resistance against metal ions, antibiotics and the development of resistant strains. Metallic nanoparticles can be used as effective growth inhibitors in various microorganisms and thereby are applicable to diverse medical devices. Nanotechnology discloses the use of elemental nanoparticles as active antibacterial ingredient for dental materials. In dentistry, both restorative materials and oral bacteria are believed to be responsible for restoration failure. Secondary caries is found to be the main reason to restoration failure. Secondary caries is primarily caused by invasion of plaque bacteria (acid-producing bacteria) such as Streptococcus mutans and lactobacilli in the presence of fermentable carbohydrates. To make long-lasting restorations, antibacterial materials should be made. The potential of nanoparticles to control the formation of biofilms within the oral cavity is also coming under increasing scrutiny. Possible uses of nanoparticles as topically applied agents within dental materials and the application of nanoparticles in the control of oral infections are also reviewed.
authors.affiliation: Department of Dental Biomaterials and Restorative Dentistry, Faculty of Dentistry, Mansoura University, Mansoura, Dakahleya 35516, Egypt.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Mohamed Hamouda
keywords: antibacterial agent; nano-biomaterials; nano-medicine; nanoparticles; nanotechnology
references.citation: Nanomedicine. 2007 Mar;3(1):95-101
references.pmid: 17379174
references.citation: Biomaterials. 2007 Nov;28(32):4880-8
references.pmid: 17697708
references.citation: Biomaterials. 2008 Mar;29(8):963-9
references.pmid: 18061256
references.citation: J Nanobiotechnology. 2010 Jan 20;8:1
references.pmid: 20145735
references.citation: Dent Mater. 2000 Jan;16(1):33-40
references.pmid: 11203521
references.citation: J Phys Chem B. 2006 Aug 24;110(33):16248-53
references.pmid: 16913750
references.citation: J Am Dent Assoc. 2003 Oct;134(10):1382-90
references.pmid: 14620019
references.citation: Microbios. 2001;104(409):141-8
references.pmid: 11327108
references.citation: Int J Antimicrob Agents. 2009 Aug;34(2):103-10
references.pmid: 19339161
references.citation: Water Res. 2008 Jun;42(12):3066-74
references.pmid: 18359055
references.citation: Appl Environ Microbiol. 2007 Mar;73(6):1712-20
references.pmid: 17261510
references.citation: Int Wound J. 2007 Jun;4(2):114-22
references.pmid: 17651227
references.citation: Appl Environ Microbiol. 2008 Apr;74(7):2171-8
references.pmid: 18245232
references.citation: Appl Environ Microbiol. 2005 Nov;71(11):7589-93
references.pmid: 16269810
references.citation: Curr Drug Targets Infect Disord. 2005 Mar;5(1):3-15
references.pmid: 15777194
references.citation: J Dent Res. 2008 Oct;87(10):980-3
references.pmid: 18809755
references.citation: Dent Mater. 2009 Aug;25(8):1001-6
references.pmid: 19332352
references.citation: J Dent. 2011 Sep;39(9):589-98
references.pmid: 21651955
references.citation: Nanotechnology. 2005 Oct;16(10):2346-53
references.pmid: 20818017
references.citation: Wound Repair Regen. 2004 May-Jun;12(3):288-94
references.pmid: 15225207
references.citation: Caries Res. 2004 Sep-Oct;38(5):430-5
references.pmid: 15316186
references.citation: Nanotechnology. 2007 May 04;18(22):
references.pmid: 37016550
references.citation: Gerodontology. 2008 Sep;25(3):187-94
references.pmid: 18194331
references.citation: J Endod. 2008 Dec;34(12):1515-20
references.pmid: 19026885
references.citation: Dent Mater. 1991 Jul;7(3):155-60
references.pmid: 1813337
references.citation: Adv Microb Physiol. 1997;38:177-243
references.pmid: 8922121
references.citation: J Dent Res. 2010 Nov;89(11):1175-86
references.pmid: 20739694
references.citation: Nature. 2008 Apr 3;452(7187):541-2
references.pmid: 18385723
references.citation: Langmuir. 2006 Nov 21;22(24):9820-3
references.pmid: 17106967
references.citation: J Biomed Mater Res. 2000 Dec 15;52(4):662-8
references.pmid: 11033548
references.citation: J Proteome Res. 2006 Apr;5(4):916-24
references.pmid: 16602699
references.citation: Open AIDS J. 2009;3:1-3
references.pmid: 19274070
references.citation: Sci Total Environ. 2008 Aug 1;400(1-3):396-414
references.pmid: 18715626
references.citation: Dent Mater. 2000 Nov;16(6):452-5
references.pmid: 10967196
references.citation: Dent Mater. 2009 Feb;25(2):206-13
references.pmid: 18632145
references.citation: J Infect Dis. 1999 Dec;180(6):1939-49
references.pmid: 10558951
references.citation: Ecotoxicol Environ Saf. 2000 Mar;45(3):198-207
references.pmid: 10702338
references.citation: J Pharm Sci. 1995 Jul;84(7):895-902
references.pmid: 7562444
references.citation: Dent Mater. 2002 Sep;18(6):429-35
references.pmid: 12098571
references.citation: Colloids Surf B Biointerfaces. 2007 May 15;57(1):97-101
references.pmid: 17350236
references.citation: Toxicol Lett. 2009 Oct 28;190(2):156-62
references.pmid: 19607894
references.citation: Adv Exp Med Biol. 2011;715:351-67
references.pmid: 21557075
references.citation: Int Dent J. 1993 Dec;43(6 Suppl 1):549-53
references.pmid: 8138326
references.citation: Biotechnol Adv. 2009 Jan-Feb;27(1):76-83
references.pmid: 18854209
references.citation: Trends Biotechnol. 2010 Nov;28(11):580-8
references.pmid: 20724010
references.citation: Dent Mater. 2011 May;27(5):487-96
references.pmid: 21388668
references.citation: Biomacromolecules. 2008 Nov;9(11):3044-50
references.pmid: 18821794
references.citation: Indian J Chest Dis Allied Sci. 2006 Jul-Sep;48(3):171-6
references.pmid: 18610673
references.citation: Colloids Surf B Biointerfaces. 2010 Aug 1;79(1):5-18
references.pmid: 20417070
references.citation: Nanomedicine. 2010 Feb;6(1):103-9
references.pmid: 19447203
references.citation: FEMS Microbiol Rev. 2003 Jun;27(2-3):341-53
references.pmid: 12829274
references.citation: J Dent Res. 2007 Aug;86(8):754-7
references.pmid: 17652205
references.citation: Int J Antimicrob Agents. 2009 Jun;33(6):587-90
references.pmid: 19195845