title: The susceptibility of T5-TG12 of the CFTR gene in chronic bronchitis occurrence in a Chinese population in Jiangsu province, China.
abstract: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders. In the present study, we investigated the role of CFTR variations, poly-T, TG-repeats, and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province, China. A total of 72 bronchial asthma patients, 68 chronic bronchitis patients, and 117 healthy subjects were included in this study. The Tn-TGm haplotype was sequenced and the CFTR variant M470V was detected using restriction fragment length polymorphism (RFLP). We found that the frequency of T5-TG12-V470 in chronic bronchitis patients was 0.07%, which was notably higher than that in healthy subjects (0.01%) and bronchial asthma patients (0.04%). Thus, the presence of the T5-TG12 haplotype of the CFTR gene is likely to play a role in the development and progression of respiratory conditions, such as chronic bronchitis.
authors.affiliation: Department of Traditional Chinese Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China;
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Satoru
authors.initials: S
authors.lastname: Naruse
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
authors.forename: Zhongfang
authors.initials: Z
authors.lastname: Yu
authors.forename: Tianqu
authors.initials: T
authors.lastname: Zhuang
authors.forename: Wei
authors.initials: W
authors.lastname: Ding
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Wu
authors.forename: Muxin
authors.initials: M
authors.lastname: Wei
keywords: Chinese population; T5-TG12; chronic bronchitis; cystic fibrosis transmembrane conductance regulator (CFTR)
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