title: Tomographic imaging via spectral encoding of spatial frequency.
abstract: Three-dimensional optical tomographic imaging plays an important role in biomedical research and clinical applications. We introduce spectral tomographic imaging (STI) via spectral encoding of spatial frequency principle that not only has the capability for visualizing the three-dimensional object at sub-micron resolution but also providing spatially-resolved quantitative characterization of its structure with nanoscale accuracy for any volume of interest within the object. The theoretical basis and the proof-of-concept numerical simulations are presented to demonstrate the feasibility of spectral tomographic imaging.
authors.affiliation: Biomedical and Optical Imaging Laboratory (BOIL), Departments of Medicine and Bioengineering, University of Pittsburgh, Pittsburgh PA 15213, USA. shf28@pitt.edu
authors.forename: Shikhar
authors.initials: S
authors.lastname: Uttam
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Alexandrov
authors.forename: Rajan K
authors.initials: RK
authors.lastname: Bista
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D013057:Spectrum Analysis / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*
references.citation: Opt Lett. 2009 Mar 1;34(5):653-5
references.pmid: 19252582
references.citation: Opt Express. 2000 Oct 23;7(9):305-10
references.pmid: 19407880
references.citation: Nat Phys. 2007 Feb 1;3(2):129-134
references.pmid: 25635181
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17255-60
references.pmid: 17956980
references.citation: Opt Lett. 2005 Sep 15;30(18):2445-7
references.pmid: 16196347
references.citation: Opt Express. 2010 Nov 22;18(24):25116-26
references.pmid: 21164858
references.citation: J Opt Soc Am A Opt Image Sci Vis. 2007 Apr;24(4):1034-41
references.pmid: 17361289
references.citation: J Microsc. 2002 Feb;205(Pt 2):165-76
references.pmid: 11879431
references.citation: J Opt Soc Am A Opt Image Sci Vis. 2006 May;23(5):1027-37
references.pmid: 16642179
references.citation: Opt Express. 2009 Jan 5;17(1):266-77
references.pmid: 19129896
references.citation: Appl Opt. 2006 Nov 10;45(32):8209-17
references.pmid: 17068564
references.citation: Nature. 2000 Jul 6;406(6791):35-6
references.pmid: 10894529
references.citation: J Biophotonics. 2010 Jul;3(7):462-7
references.pmid: 20209580
references.citation: Opt Lett. 1994 Apr 15;19(8):590-2
references.pmid: 19844382
references.citation: Opt Express. 2009 Jul 6;17(14):12001-12
references.pmid: 19582115
references.citation: Appl Opt. 2007 Apr 1;46(10):1760-9
references.pmid: 17356619
references.citation: Cancer Res. 2009 Feb 1;69(3):1199-204
references.pmid: 19141640
references.citation: Invest Ophthalmol Vis Sci. 1991 Mar;32(3):616-24
references.pmid: 2001935
references.citation: Appl Phys Lett. 2012 Jul 16;101(3):33702
references.pmid: 22893731
references.citation: Opt Express. 2012 Apr 9;20(8):9203-14
references.pmid: 22513632
references.citation: Opt Lett. 2005 Aug 15;30(16):2092-4
references.pmid: 16127920
references.citation: Opt Lett. 2001 Jul 15;26(14):1063-5
references.pmid: 18049520
references.citation: Science. 1991 Nov 22;254(5035):1178-81
references.pmid: 1957169
references.citation: Opt Lett. 2003 Jul 15;28(14):1230-2
references.pmid: 12885030
references.citation: Opt Lett. 2009 Jan 1;34(1):79-81
references.pmid: 19109646