title: Choroidal and cutaneous metastasis from gastric adenocarcinoma.
abstract: Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions.
authors.affiliation: Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Kawai
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nishida
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Hisao
authors.initials: H
authors.lastname: Ezaki
authors.forename: Takuya
authors.initials: T
authors.lastname: Yamada
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Shinzaki
authors.forename: Masanori
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Kei
authors.initials: K
authors.lastname: Nakai
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yakushijin
authors.forename: Kenji
authors.initials: K
authors.lastname: Watabe
authors.forename: Hideki
authors.initials: H
authors.lastname: Iijima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujii
authors.forename: Kohji
authors.initials: K
authors.lastname: Nishida
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Takehara
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D002830:Choroid Neoplasms / Q000188:drug therapy / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D016099:Endoscopy, Gastrointestinal; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging / Q000379:methods; D010094:Oxonic Acid / Q000008:administration & dosage; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D012535:Scalp / Q000187:drug effects / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*; D005641:Tegafur / Q000008:administration & dosage; D015899:Tomography, Emission-Computed, Single-Photon; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin
keywords: Choroid neoplasms; Neoplasm metastasis; Skin neoplasms; Stomach neoplasms
references.citation: J Am Acad Dermatol. 1995 Aug;33(2 Pt 1):161-82; quiz 183-6
references.pmid: 7622642
references.citation: Int J Clin Oncol. 2004 Apr;9(2):74-8
references.pmid: 15108037
references.citation: Can J Ophthalmol. 2007 Apr;42(2):331-2
references.pmid: 17392868
references.citation: Radiology. 1988 Sep;168(3):773-9
references.pmid: 3406407
references.citation: Arch Dermatol. 1972 Jun;105(6):862-8
references.pmid: 5030236
references.citation: Lancet Oncol. 2008 Mar;9(3):215-21
references.pmid: 18282805
references.citation: Cochrane Database Syst Rev. 2007 Jan 24;(1):CD005413
references.pmid: 17253556
references.citation: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references.pmid: 21296855
references.citation: Ophthalmology. 1997 Aug;104(8):1265-76
references.pmid: 9261313
references.citation: AJNR Am J Neuroradiol. 1993 Nov-Dec;14(6):1359-66
references.pmid: 8279332
references.citation: Am J Clin Oncol. 1992 Dec;15(6):503-5
references.pmid: 1449114
references.citation: Arq Bras Oftalmol. 2010 Sep-Oct;73(5):467-8
references.pmid: 21225136
references.citation: J Am Acad Dermatol. 2009 Mar;60(3):379-87
references.pmid: 19056145
references.citation: Cancer. 1972 May;29(5):1298-307
references.pmid: 4336632