title: [Severe hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone].
abstract: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a common and multifactorial cause of hyponatremia that is often overlooked. The common pathophysiological mechanism is the increased production and/or action of antidiuretic hormone within the kidney, resulting in hypotonic hyponatremia. Inadequate correction of hyponatremia may have fatal neurological consequences leading to central pontine myelinolysis. We report the case of a patient with a history of recent head trauma, who came to our observation for acute-onset mental confusion secondary to severe hyponatremia due to SIADH of combined etiology.
authors.forename: Luca
authors.initials: L
authors.lastname: Foppiani
authors.forename: Francesca
authors.initials: F
authors.lastname: Raggi
authors.forename: Milena
authors.initials: M
authors.lastname: Tagliabue
authors.forename: Andrea
authors.initials: A
authors.lastname: Benso
authors.forename: Irene
authors.initials: I
authors.lastname: Brandolin
authors.forename: Giuliano
authors.initials: G
authors.lastname: Lo Pinto
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines / Q000627:therapeutic use; D001930:Brain Injuries / Q000150:complications; D003221:Confusion / Q000209:etiology; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000150:complications* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000150:complications; D010286:Paraventricular Hypothalamic Nucleus / Q000293:injuries / Q000378:metabolism; D011595:Psychomotor Agitation / Q000209:etiology; D012206:Rhabdomyolysis / Q000150:complications; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use; D013495:Supraoptic Nucleus / Q000293:injuries / Q000378:metabolism; D000077602:Tolvaptan
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines; D012462:Saline Solution, Hypertonic; D000077602:Tolvaptan