title: Influence of aerobic training on neurohormonal and hemodynamic responses to head-up tilt test and on autonomic nervous activity at rest and after exercise in patients after bypass surgery.
abstract: BACKGROUND
  Little is known about the influence of aerobic training on the neurohormonal and hemodynamic responses to head-up tilt (HUT) and on autonomic balance at rest and after exercise in optimally treated, low risk post-coronary artery bypass grafting (CABG) patients.
  
  
  METHODS
  One hundred male patients, mean age 56 ± 6 years, 3 months after CABG, were randomized to either 6-week training on cycloergometer, 3 times a week, at 70-80% of max tolerated heart rate (HR) (training group, n = 50) or to a control group (n = 50). At baseline and at the end of the study, all patients underwent: (1) cardiopulmonary exercise test with HR recovery (HRR) assessment; (2) 60% HUT during which HR, blood pressure (BP), stroke volume (SV by impedance cardiography) were monitored and blood samples were taken for determination of plasma catecholamines and ANP levels, and plasma renin activity; (3) assessment of HR variability (HRV) in the time and frequency domains at rest.
  
  
  RESULTS
  During the final tests, HUT-induced changes in HR, BP, SV, cardiac output, total peripheral resistance, and noradrenaline were significantly lower in training group than in controls. In addition, after training faster post-exercise HRR, increased SDNN and a tendency towards an increase in the high frequency HRV power spectrum were found.
  
  
  CONCLUSIONS
  Aerobic training improved neurohormonal and hemodynamic responses to head-up tilt test and favorably modified sympatho-vagal balance in low risk post-CABG patients.
authors.forename: Maria
authors.initials: M
authors.lastname: Bilińska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kosydar-Piechna
authors.forename: Tomasz
authors.initials: T
authors.lastname: Mikulski
authors.forename: Ewa
authors.initials: E
authors.lastname: Piotrowicz
authors.forename: Anna
authors.initials: A
authors.lastname: Gąsiorowska
authors.forename: Walerian
authors.initials: W
authors.lastname: Piotrowski
authors.forename: Krystyna
authors.initials: K
authors.lastname: Nazar
authors.forename: Ryszard
authors.initials: R
authors.lastname: Piotrowicz
mesh_terms: D001341:Autonomic Nervous System / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001026:Coronary Artery Bypass / Q000534:rehabilitation*; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000534:rehabilitation / Q000601:surgery; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000502:physiology; D012146:Rest / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D018667:Tilt-Table Test; D016896:Treatment Outcome
chemical_list: D018377:Neurotransmitter Agents