title: Diastereoselective synthesis of vicinal cis-dihydroxyheterospirocycles by one-pot epoxidation/spirocyclization of C(3)-functionalized cyclohex-2-en-1-ols.
abstract: Spirolactones, spirotetrahydrofurans, and spiropyrrolidines containing a vicinal cis-diol adjacent to the spiro-carbon center are prepared by one-pot epoxidation/spirocyclization of cyclohex-2-en-1-ols bearing an ester, alcohol, or amide functional side chain at the C(3) position of the ring.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan. cheyeh@ntnu.edu.tw
authors.forename: Ming-Chang P
authors.initials: MC
authors.lastname: Yeh
authors.forename: Chia-Jung
authors.initials: CJ
authors.lastname: Liang
authors.forename: Cheng-Yuan
authors.initials: CY
authors.lastname: Liu
authors.forename: Ya-fon
authors.initials: YF
authors.lastname: Shih
authors.forename: I-Chen
authors.initials: IC
authors.lastname: Lee
authors.forename: Hsiang-Fang
authors.initials: HF
authors.lastname: Liu
authors.forename: Jeng-Long
authors.initials: JL
authors.lastname: Wang
mesh_terms: D018360:Crystallography, X-Ray; D003500:Cyclization; D003511:Cyclohexanols / Q000138:chemical synthesis* / Q000737:chemistry; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003511:Cyclohexanols; D004852:Epoxy Compounds; D013141:Spiro Compounds