title: Insulin resistance and risk of cerebral infarction in a Japanese general population: the Jichi Medical School Cohort Study.
abstract: The aim of the study was to investigate the relation between insulin resistance and risk of cerebral infarction in a Japanese general population. The subjects were 2610 men and women without past history of stroke or myocardial infarction and who were under treatment for diabetes. Subjects were divided into quartiles by the homeostasis model assessment of insulin resistance (HOMA-IR), and Cox's proportional hazard model was used to calculate hazard ratios (HRs) for cerebral infarction. In men, the multivariate-adjusted HRs were 2.51 (95% confidence interval [CI] = 0.98-6.42) in quartile 1 (Q1), 1.43 (95% CI = 0.54-3.82) in Q2, and 2.13 (95% CI = 0.82-5.51) in Q4, using Q3 as the reference. In women, the multivariate-adjusted HRs were 2.12 (95% CI = 0.72-6.31) in Q1, 2.96 (95% CI = 1.06-8.26) in Q3, and 2.31 (95% CI = 0.80-6.69) in Q4, using Q2 as the reference. The association between risk of cerebral infarction and HOMA-IR was not dose dependent.
authors.affiliation: Jichi Medical University, Tochigi, Japan ykaneda819@yahoo.co.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kaneda
authors.affiliation: Jichi Medical University, Tochigi, Japan.
authors.forename: Shizukiyo
authors.initials: S
authors.lastname: Ishikawa
authors.affiliation: Jichi Medical University, Tochigi, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sadakane
authors.affiliation: Wara National Health Insurance Clinic, Gujo, Gifu, Japan.
authors.forename: Tadao
authors.initials: T
authors.lastname: Gotoh
authors.affiliation: Saitama Prefectural University, Saitama, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kayaba
authors.affiliation: Jichi Medical University, Tochigi, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Yasuda
authors.affiliation: Jichi Medical University, Tochigi, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Kajii
mesh_terms: D000328:Adult; D000368:Aged; D002544:Cerebral Infarction / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012306:Risk; D012307:Risk Factors; D012577:Schools, Medical; D012737:Sex Factors
keywords: Japan; cerebral infarction; cohort study; homeostasis model assessment for insulin resistance; insulin resistance