title: Saccharosporones A, B and C, cytotoxic antimalarial angucyclinones from Saccharopolyspora sp. BCC 21906.
abstract: Three new angucyclinones, saccharosporones A, B and C, together with (+)-ochromycinone, (+)-rubiginone B2, tetrangulol methyl ether and fujianmycin A, were obtained from fermentation of the terrestrial actinomycete of the genus Saccharopolyspora BCC 21906 isolated from a soil collected in Chanthaburi Province, Thailand. Structures of the new compounds and their relative configurations were assigned by NMR spectral data interpretation. Saccharosporones A and B exhibited antimalarial activity against Plasmodium falciparum K1 with IC50 values of 4.1 and 3.9 μM. Both metabolites also possessed cytotoxic activities against cancer cell lines (KB, MCF-7 and NCI-H187) and nonmalignant Vero cell, while saccharosporone C only showed cytotoxic activity against NCI-H187.
authors.affiliation: National Center for Genetic Engineering and Biotechnology BIOTEC, Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand. chollaratt.boo@biotec.or.th
authors.forename: Chollaratt
authors.initials: C
authors.lastname: Boonlarppradab
authors.forename: Chanwit
authors.initials: C
authors.lastname: Suriyachadkun
authors.forename: Pranee
authors.initials: P
authors.lastname: Rachtawee
authors.forename: Wilunda
authors.initials: W
authors.lastname: Choowong
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects; D001551:Benz(a)Anthracenes / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002522:Chlorocebus aethiops; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D016930:Saccharopolyspora / Q000737:chemistry*; D012988:Soil Microbiology; D013785:Thailand; D014709:Vero Cells; D000095602:Angucyclines and Angucyclinones
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D000962:Antimalarials; D001551:Benz(a)Anthracenes; C510997:angucyclinone; C510996:rubiginone B2; D000095602:Angucyclines and Angucyclinones; C583204:saccharosporone A; C583205:saccharosporone B; C103670:tetrangulol; C045694:fujianmycin A; C510995:ochromycinone