title: Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics.
abstract: A series of six mononuclear Cu(II) complexes with pyrazole-based ligands: 5-(2-hydroxybenzoyl)-3-methyl-1-(2-pyridinyl)-1H-pyrazol-4-phosphonic acid dimethyl ester (1a), 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1H-pyrazole-4-carboxylic acid methyl ester (1b) and 1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (1c) were characterized regarding to electrochemical and antioxidant properties. All complexes exhibit suitable Cu(II)/Cu(I) redox potential (E1/2) to act as antioxidant enzymes mimic. The five of these complexes were found to be trifunctional enzyme mimics possessing SOD, CAT and GPx-like catalytic activities. Moreover, Cu(II) complexes were capable to decrease ROS level in melanoma cells and observed effects were not merely a reflection of cytotoxicity.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Curie-Sklodowskiej 9, 85-094 Bydgoszcz, Poland.
authors.forename: Bogumiła
authors.initials: B
authors.lastname: Kupcewicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sobiesiak
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Malinowska
authors.forename: Kamila
authors.initials: K
authors.lastname: Koprowska
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Czyz
authors.forename: Bernhard
authors.initials: B
authors.lastname: Keppler
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Budzisz
keywords: Copper(II) complexes; Cyclic voltammetry; Enzyme mimic; Pyrazoles; Reactive oxygen species
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