title: Performance on Paced Auditory Serial Addition Test and cerebral blood flow in multiple sclerosis.
abstract: BACKGROUND
  To assess the relationship between performance on the Paced Auditory Serial Addition Test (PASAT) and both cerebral blood flow (CBF) and axonal metabolic integrity in normal appearing white matter (NAWM) of the centrum semiovale in patients with multiple sclerosis (MS).
  
  
  METHODS
  Normal appearing white matter of the centrum semiovale was investigated with magnetic resonance (MR) imaging in 28 non-depressed individuals (18 patients with MS and 10 healthy controls). CBF was assessed with pseudo-continuous arterial spin labeling. N-acetylacetate/creatine (NAA/Cr) ratios (a metabolic axonal marker) were measured using (1) H-MR spectroscopy. CBF was also measured in frontoparietal cortices and cerebellar hemispheres.
  
  
  RESULTS
  In subjects with MS, we found a positive correlation between performance on the PASAT and CBF to the left centrum semiovale (P = 0.008), but not with the NAA/Cr ratio. There were no correlations between PASAT scores and CBF to the right centrum semiovale, frontoparietal cortices, and cerebellar hemispheres. There was no correlation between PASAT scores and NAA/Cr ratios.
  
  
  CONCLUSIONS
  Our preliminary results suggest that performance on the PASAT in subjects with MS correlates with CBF to the left centrum semiovale, which contains left frontoparietal white matter association tracts involved in information processing speed and working memory.
authors.affiliation: Department of Neurology, Universitair Ziekenhuis Brussel, Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: D'haeseleer
authors.forename: C
authors.initials: C
authors.lastname: Steen
authors.forename: J M
authors.initials: JM
authors.lastname: Hoogduin
authors.forename: M J P
authors.initials: MJ
authors.lastname: van Osch
authors.forename: Y
authors.initials: Y
authors.lastname: Fierens
authors.forename: M
authors.initials: M
authors.lastname: Cambron
authors.forename: M W
authors.initials: MW
authors.lastname: Koch
authors.forename: J
authors.initials: J
authors.lastname: De Keyser
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003401:Creatine / Q000134:cerebrospinal fluid; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000503:physiopathology*; D018709:Statistics, Nonparametric; D014316:Tritium
chemical_list: D014316:Tritium; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine
keywords: Paced Auditory Serial Addition Test; cerebral blood flow; cognition; magnetic resonance spectroscopy; multiple sclerosis