title: S100A12 levels in synovial fluid may reflect clinical severity in patients with primary knee osteoarthritis.
abstract: This study aims to detect S100A12 in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate their correlation with clinical severity of the disease. This study enrolled 198 OA patients and 84 healthy controls. The radiological/symptomatic severity of the disease was assessed by the Kellgren-Lawrence (KL) grading system/Western Ontario McMaster University Osteoarthritis (WOMAC) scores. We demonstrated that S100A12 levels in SF but not serum were independently associated with KL grades and WOMAC scores. These results suggested that the S100A12 in SF might be a potential biomarker for predicting the development and progression of knee OA.
authors.affiliation: Department of Orthopedics, 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China. hljwanglch@126.com
authors.forename: Li-Chun
authors.initials: LC
authors.lastname: Wang
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Shao
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Ze-Han
authors.initials: ZH
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: He
authors.forename: Wei-Xun
authors.initials: WX
authors.lastname: Gong
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism*; D000067616:S100A12 Protein; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D009418:S100 Proteins; D000067616:S100A12 Protein; C090441:S100A12 protein, human