title: Prediction of postoperative pulmonary function: preliminary comparison of single-breath dual-energy xenon CT with three conventional methods.
abstract: OBJECTIVE
  To assess the use of xenon ventilation maps (Xe-images) for predicting postoperative pulmonary function.
  
  
  METHODS
  After study approval by the institutional review board, written informed consent was obtained from 30 patients with lung tumors who underwent pre- and postoperative spirometry, pulmonary perfusion SPECT and dual-energy CT (80 kV and 140 kV/Sn) after single-breath inspiration of 35 % xenon. Xe-images were calculated by three-material decomposition. Sum of pixel values of the part to be resected (A) and of the whole lung (B) on Xe-images or lung perfusion SPECT, and volumes or the number of segments of the part to be resected (A) and of the whole lung (B) on Xe-images were enumerated, respectively. We multiplied (1 - A/B) by each preoperative value from spirometry for prediction. Predictions by each of the four methods were compared with postoperative values.
  
  
  RESULTS
  Predicted values for vital capacity (VC), forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) by the four methods regressed significantly with measured values (R (2) = 0.56-0.77, p < 0.001 for all).
  
  
  CONCLUSIONS
  Analysis of Xe-images can predict postoperative VC, FVC and FEV1 with accuracy comparable to that of CT volumetry.
authors.affiliation: Department of Radiology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan. hyanagit@saitama-med.ac.jp
authors.forename: Hisami
authors.initials: H
authors.lastname: Yanagita
authors.forename: Norinari
authors.initials: N
authors.lastname: Honda
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Nakayama
authors.forename: Wataru
authors.initials: W
authors.lastname: Watanabe
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Hisato
authors.initials: H
authors.lastname: Osada
authors.forename: Kei
authors.initials: K
authors.lastname: Nakada
authors.forename: Takemichi
authors.initials: T
authors.lastname: Okada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohno
authors.forename: Takeo
authors.initials: T
authors.lastname: Takahashi
authors.forename: Katharina
authors.initials: K
authors.lastname: Otani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011184:Postoperative Period; D011237:Predictive Value of Tests; D012123:Pulmonary Ventilation; D015900:Radiography, Dual-Energy Scanned Projection / Q000379:methods*; D012680:Sensitivity and Specificity; D013147:Spirometry; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014797:Vital Capacity; D014978:Xenon
chemical_list: D003287:Contrast Media; D014978:Xenon
references.citation: Chest. 1972 Dec;62(6):694-8
references.pmid: 4635418
references.citation: Clin Radiol. 1982 Jul;33(4):379-87
references.pmid: 7083738
references.citation: Acad Radiol. 2007 Jul;14(7):830-8
references.pmid: 17574133
references.citation: Chest. 1995 Jul;108(1):68-72
references.pmid: 7606994
references.citation: Eur Respir J. 2005 Aug;26(2):319-38
references.pmid: 16055882
references.citation: Respiration. 2002;69(6):482-9
references.pmid: 12456999
references.citation: Radiology. 2010 Sep;256(3):985-97
references.pmid: 20651060
references.citation: AJR Am J Roentgenol. 2002 Mar;178(3):667-72
references.pmid: 11856695
references.citation: Acad Radiol. 2010 Apr;17(4):489-95
references.pmid: 20060751
references.citation: Acad Radiol. 2010 May;17(5):607-13
references.pmid: 20188601
references.citation: Radiology. 2008 Sep;248(3):995-1003
references.pmid: 18710988
references.citation: Eur J Cardiothorac Surg. 2009 Mar;35(3):408-13
references.pmid: 19162496
references.citation: Chest. 2007 Sep;132(3 Suppl):161S-77S
references.pmid: 17873167
references.citation: AJR Am J Roentgenol. 2008 Mar;190(3):762-9
references.pmid: 18287450
references.citation: Ann Nucl Med. 2010 Jul;24(6):447-53
references.pmid: 20379857
references.citation: Chest. 1990 Feb;97(2):315-21
references.pmid: 2298057
references.citation: Ann Nucl Med. 1993 May;7(2):123-6
references.pmid: 8391294
references.citation: Radiology. 2012 Jan;262(1):262-8
references.pmid: 22025733
references.citation: Eur J Nucl Med Mol Imaging. 2006 Sep;33(9):1048-54
references.pmid: 16639608
references.citation: Ann Thorac Surg. 2004 Oct;78(4):1215-8
references.pmid: 15464473
references.citation: Radiology. 2008 Aug;248(2):615-24
references.pmid: 18641254
references.citation: Interact Cardiovasc Thorac Surg. 2008 Dec;7(6):1019-23
references.pmid: 18687696
references.citation: J Thorac Cardiovasc Surg. 1980 Oct;80(4):535-43
references.pmid: 7421288
references.citation: Pediatr Radiol. 2010 Sep;40(9):1490-7
references.pmid: 20411254
references.citation: Radiology. 1994 Apr;191(1):257-62
references.pmid: 8134584
references.citation: Chest. 1980 Mar;77(3):337-42
references.pmid: 7357934