title: Effects of combined application of muscle relaxants and celecoxib administration after total knee arthroplasty (TKA) on early recovery: a randomized, double-blind, controlled study.
abstract: The purpose of this study was to evaluate the effectiveness of application of muscle relaxants and celecoxib in early recovery after total knee arthroplasty (TKA). One hundred and fifty patients were randomized 1:1:1 to receive either both of muscle relaxants and celecoxib or muscle relaxants alone or placebo for 2 weeks (50 patients in each group). VAS pain scores as primary efficacy, active range of motion, morphine consumption, blood loss, and postoperative complications including postoperative nausea and vomiting (PONV), extremities myasthenia and deep vein thrombosis (DVT) were determined postoperatively. Group A improved better with reduced VAS pain scores compared with another two groups. These results demonstrated that application of muscle relaxants and celecoxib into patients undergoing TKA for 2 weeks postoperative consequently improved their convalescence.
authors.affiliation: Department of Orthopedics, Chinese PLA General Hospital & Chinese, PLA Postgraduate Medical School, Beijing, China.
authors.forename: Long
authors.initials: L
authors.lastname: Gong
authors.forename: Ji-Yuan
authors.initials: JY
authors.lastname: Dong
authors.forename: Zhi-Rui
authors.initials: ZR
authors.lastname: Li
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D007719:Knee Joint / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000494:pharmacology / Q000627:therapeutic use*; D020370:Osteoarthritis, Knee / Q000601:surgery*; D010149:Postoperative Pain / Q000453:epidemiology; D019106:Postoperative Hemorrhage / Q000453:epidemiology; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology; D011184:Postoperative Period; D011427:Propiophenones / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use*; D016059:Range of Motion, Articular / Q000187:drug effects / Q000502:physiology; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000453:epidemiology
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D009125:Muscle Relaxants, Central; D011427:Propiophenones; D011720:Pyrazoles; D013449:Sulfonamides; C030848:eperisone; D000068579:Celecoxib
keywords: celecoxib; muscle relaxant; postoperative pain; rehabilitation; total knee arthroplasty (TKA)