title: [Radiobiology in brachytherapy].
abstract: Low-dose rate brachytherapy has some radiobiological advantages compared to external beam radiotherapy: subletal damages repair during irradiation leading to a relative protection of healthy tissues; no tumor cell repopulation, cell cycle redistribution and a low oxygen enhancement ratio. High dose rate and pulsed dose rate modalities allow an optimization of dose distribution by varying the dwell times over the different dwell positions. Because of the use of afterloaders, they also offer a better radioprotection of the staff. High dose rate and pulsed dose rate treatments seem to offer the same results as low-dose rate brachytherapy, particularly in cervix carcinoma. For high dose rate brachytherapy, schedules must be designed according to the linear-quadratic model. In pulsed dose rate brachytherapy, pulse dose and time intervals must also be derived from the linear-quadratic model, but half-time repair must be taken into account.
authors.affiliation: Service de cancérologie-radiothérapie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75475 Paris, France. christophe.hennequin@sls.aphp.fr
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
authors.forename: J-J
authors.initials: JJ
authors.lastname: Mazeron
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods; D002453:Cell Cycle / Q000528:radiation effects; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D004249:DNA Damage; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes / Q000627:therapeutic use; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D008297:Male; D009369:Neoplasms / Q000532:radiotherapy; D059351:Organ Sparing Treatments; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012062:Relative Biological Effectiveness
chemical_list: D003037:Cobalt Radioisotopes; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D007496:Iridium Radioisotopes