title: Neuroanatomical distribution of μ-opioid receptor mRNA and binding in monogamous prairie voles (Microtus ochrogaster) and non-monogamous meadow voles (Microtus pennsylvanicus).
abstract: The opiate system has long been implicated in the rewarding properties of social interactions. In particular, the μ-opioid receptor (MOR) mediates multiple forms of social attachment, including the attachment of offspring to the mother and social bonding between mates. We have previously shown that MOR in the caudate-putamen is involved in partner preference formation in monogamous prairie voles. Here, using in situ hybridization and receptor autoradiography, we mapped in detail the distribution of MOR mRNA and ligand binding in monogamous prairie vole brains and compared MOR binding density with that of promiscuous meadow vole brains. Comparison of MOR binding in these closely related species with distinctly different social behavior revealed that while the distribution of MOR is similar, prairie voles have significantly higher densities of MOR than meadow voles in a majority of regions in the forebrain, including the caudate-putamen, nucleus accumbens shell, lateral septum and several thalamic nuclei, including the anteroventral and anteromedial thalamic nuclei. These differences in MOR expression between prairie and meadow voles could potentially contribute to species differences in behavior, including social attachment.
authors.affiliation: Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, United States. kinoue@emory.edu
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: J P
authors.initials: JP
authors.lastname: Burkett
authors.forename: L J
authors.initials: LJ
authors.lastname: Young
mesh_terms: D000818:Animals; D003411:Arvicolinae / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005260:Female; D008297:Male; D010152:Pair Bond; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D012919:Social Behavior; D013045:Species Specificity
chemical_list: D017450:Receptors, Opioid, mu
references.citation: Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):15079-84
references.pmid: 19706472
references.citation: Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1544-9
references.pmid: 9037090
references.citation: J Comp Neurol. 2005 Jun 20;487(1):75-92
references.pmid: 15861459
references.citation: Nat Neurosci. 2004 Oct;7(10):1048-54
references.pmid: 15452576
references.citation: Behav Neurosci. 2011 Apr;125(2):131-6
references.pmid: 21463018
references.citation: Brain Res. 1988 Feb 9;440(2):285-92
references.pmid: 3359215
references.citation: Brain Res. 2002 Jul 26;945(1):9-19
references.pmid: 12113946
references.citation: J Comp Neurol. 1995 May 8;355(3):418-26
references.pmid: 7636023
references.citation: Brain Res. 1975 Aug 22;94(1):115-131
references.pmid: 167913
references.citation: J Neurosci. 2009 Feb 4;29(5):1312-8
references.pmid: 19193878
references.citation: J Neurosci. 2007 Sep 5;27(36):9721-8
references.pmid: 17804632
references.citation: Eur J Pharmacol. 1985 May 28;112(1):65-71
references.pmid: 2990966
references.citation: Dev Psychobiol. 1995 Mar;28(2):71-84
references.pmid: 8529786
references.citation: Horm Behav. 2011 Nov;60(5):498-504
references.pmid: 21851821
references.citation: Trends Neurosci. 2010 Feb;33(2):103-9
references.pmid: 20005580
references.citation: Pharmacol Biochem Behav. 1982 Apr;16(4):653-9
references.pmid: 6280208
references.citation: Soc Cogn Affect Neurosci. 2012 Jun;7(5):542-7
references.pmid: 21742765
references.citation: J Neurosci. 2008 Dec 24;28(52):14007-17
references.pmid: 19109484
references.citation: Physiol Behav. 1996 Aug;60(2):439-46
references.pmid: 8840904
references.citation: Soc Neurosci. 2011;6(1):76-87
references.pmid: 20503133
references.citation: Synapse. 2000 Apr;36(1):12-20
references.pmid: 10700022
references.citation: Behav Neurosci. 1990 Feb;104(1):177-82
references.pmid: 2156520
references.citation: Nat Rev Neurosci. 2001 Feb;2(2):129-36
references.pmid: 11252992
references.citation: Neuroscience. 2009 Mar 17;159(2):526-39
references.pmid: 19166913
references.citation: Neurosci Biobehav Rev. 1980 Winter;4(4):473-87
references.pmid: 6258111
references.citation: Int Clin Psychopharmacol. 1995 Jan;9 Suppl 4:41-5
references.pmid: 7622823
references.citation: Nature. 2004 Jun 17;429(6993):754-7
references.pmid: 15201909
references.citation: Pharmacol Rev. 1999 Jun;51(2):341-96
references.pmid: 10353987
references.citation: Brain Res. 1994 Apr 18;643(1-2):245-65
references.pmid: 8032920
references.citation: Neurosci Biobehav Rev. 1998 May;22(3):437-52
references.pmid: 9579331
references.citation: Nat Rev Neurosci. 2008 Apr;9(4):314-20
references.pmid: 18354400
references.citation: J Neurosci. 2011 Jan 5;31(1):281-8
references.pmid: 21209213
references.citation: Brain Res. 1997 Dec 5;778(1):73-88
references.pmid: 9462879
references.citation: J Neurochem. 1994 Jun;62(6):2099-105
references.pmid: 8189219
references.citation: Pharmacol Biochem Behav. 2011 Oct;99(4):676-82
references.pmid: 21703297
references.citation: Psychoneuroendocrinology. 1993;18(4):307-21
references.pmid: 8391149
references.citation: Horm Behav. 2013 Mar;63(3):518-26
references.pmid: 23370363
references.citation: Eur Neuropsychopharmacol. 2003 Dec;13(6):424-34
references.pmid: 14636958
references.citation: Int J Dev Neurosci. 2005 Apr-May;23(2-3):235-43
references.pmid: 15749248
references.citation: Neuroscience. 2003;121(3):537-44
references.pmid: 14568015
references.citation: Neuroscience. 1986 Nov;19(3):847-56
references.pmid: 3025771
references.citation: J Neurosci. 2012 May 16;32(20):6771-84
references.pmid: 22593047
references.citation: Biol Psychiatry. 1978 Oct;13(5):607-18
references.pmid: 83167
references.citation: Psychopharmacology (Berl). 2012 Nov;224(1):1-26
references.pmid: 22885871
references.citation: Behav Brain Res. 2005 May 28;160(2):277-85
references.pmid: 15863224
references.citation: Pharmacol Biochem Behav. 1978 Aug;9(2):213-20
references.pmid: 568801
references.citation: Exp Brain Res. 1998 Nov;123(1-2):60-76
references.pmid: 9835393
references.citation: Neuropsychopharmacology. 2011 Oct;36(11):2200-10
references.pmid: 21734650
references.citation: Physiol Rev. 2009 Oct;89(4):1379-412
references.pmid: 19789384
references.citation: Horm Behav. 2001 Sep;40(2):133-8
references.pmid: 11534973
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):835-9
references.pmid: 6198696
references.citation: Reg Anesth Pain Med. 2007 May-Jun;32(3):242-6
references.pmid: 17543821
references.citation: Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5277-81
references.pmid: 18378897
references.citation: Horm Behav. 2007 Apr;51(4):508-15
references.pmid: 17320879
references.citation: J Comp Neurol. 2000 Jun 26;422(2):181-90
references.pmid: 10842226
references.citation: Genomics. 1994 Jan 15;19(2):405-6
references.pmid: 8188281
references.citation: Physiol Behav. 2003 Aug;79(3):351-7
references.pmid: 12954430
references.citation: Science. 2004 Jun 25;304(5679):1983-6
references.pmid: 15218152
references.citation: J Neurosci. 1987 Aug;7(8):2445-64
references.pmid: 3039080
references.citation: Eur J Neurosci. 2004 Dec;20(11):2909-16
references.pmid: 15579145