title: Downregulation of miR-383 promotes glioma cell invasion by targeting insulin-like growth factor 1 receptor.
abstract: Invasiveness is a major clinical feature of glioma, an aggressive brain tumor with poor prognosis. Although there is emerging evidence that some microRNAs are involved in the glioma cell invasion process, it remains necessary to find functional microRNAs and elucidate the underlying molecular mechanisms. Here, we reported that a microRNA, miR-383, was downregulated in gliomas and inversely correlated with glioma pathological grades. Downregulation of miR-383 enhanced, whereas upregulation of miR-383 inhibited, the glioma cell invasive ability. Furthermore, we found that downregulation of miR-383 activated the AKT signaling following upregulation of MMP2 expression by directly targeting insulin-like growth factor 1 receptor (IGF1R). Importantly, we demonstrated that IGF1R expression is critical for miR-383 downregulation-induced cell invasion. Taken together, these findings uncover a novel regulatory mechanism for constitutive IGF1R signaling activation in glioma cancer and may provide miR-383 as a useful diagnostic marker or therapeutic target.
authors.affiliation: Department of Paediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yan Jiang West Road, Guangzhou, 510120 Guangdong, People's Republic of China. zwHe2013@yahoo.com
authors.forename: Zhanwen
authors.initials: Z
authors.lastname: He
authors.forename: Danyang
authors.initials: D
authors.lastname: Cen
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Luo
authors.forename: Dongfang
authors.initials: D
authors.lastname: Li
authors.forename: Pinggan
authors.initials: P
authors.lastname: Li
authors.forename: Liyang
authors.initials: L
authors.lastname: Liang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Meng
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D015536:Down-Regulation; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D051058:Oncogene Protein v-akt / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C558685:MIRN383 microRNA, human; D035683:MicroRNAs; D017526:Receptor, IGF Type 1; D051058:Oncogene Protein v-akt; D051057:Proto-Oncogene Proteins c-akt; D020778:Matrix Metalloproteinase 2
references.citation: Mol Endocrinol. 2012 Jul;26(7):1129-43
references.pmid: 22593182
references.citation: Biochim Biophys Acta. 2010 Apr;1805(2):209-17
references.pmid: 19931352
references.citation: Nat Rev Cancer. 2012 Feb 16;12(3):159-69
references.pmid: 22337149
references.citation: J Biol Chem. 2004 May 7;279(19):19683-90
references.pmid: 14993222
references.citation: Oncogene. 2003 Feb 20;22(7):974-82
references.pmid: 12592384
references.citation: J Clin Oncol. 2006 Mar 10;24(8):1273-80
references.pmid: 16525182
references.citation: Cell. 2004 Jan 23;116(2):281-97
references.pmid: 14744438
references.citation: N Engl J Med. 2005 Mar 10;352(10):987-96
references.pmid: 15758009
references.citation: Breast Cancer Res Treat. 2012 Dec;136(3):717-27
references.pmid: 23117852
references.citation: Adv Cancer Res. 1996;68:183-223
references.pmid: 8712068
references.citation: Curr Opin Oncol. 2011 Nov;23(6):643-7
references.pmid: 21825990
references.citation: Neurosurgery. 2006 Apr;58(4):701-9; discussion 701-9
references.pmid: 16575334
references.citation: Brain Pathol. 2013 Jul;23(4):413-25
references.pmid: 23227829
references.citation: Cell Death Dis. 2010 Nov 04;1:e94
references.pmid: 21368870
references.citation: Med Oncol. 2012 Mar;29(1):384-91
references.pmid: 21258880
references.citation: Prostate. 2010 Feb 1;70(2):206-18
references.pmid: 19790231
references.citation: Neuro Oncol. 2010 Jan;12(1):19-27
references.pmid: 20150364
references.citation: Med Oncol. 2011 Dec;28(4):1469-74
references.pmid: 20480266
references.citation: Neoplasia. 2009 Sep;11(9):835-45
references.pmid: 19724677
references.citation: Semin Oncol. 2004 Oct;31(5):618-34
references.pmid: 15497115
references.citation: Neuro Oncol. 1999 Apr;1(2):109-19
references.pmid: 11550306
references.citation: Clin Lung Cancer. 2012 Mar;13(2):136-42
references.pmid: 22133293
references.citation: Cancer Genet. 2012 Dec;205(12):613-21
references.pmid: 23238284