title: T(2)-weighted combined with diffusion-weighted images for evaluating prostatic transition zone tumors at 3 Tesla.
abstract: OBJECTIVE
  We hypothesize that the combination of T(2)-weighted (T(2)W) MRI with diffusion-weighted imaging (DWI) methods provides a powerful clinical application for the differential diagnosis of prostate cancer and benign lesion in the prostatic transition zone (TZ).
  
  
  METHODS
  This retrospective study included 113 patients who were diagnosed with TZ lesions by MRI. The apparent diffusion coefficient values were compared between biopsy-proven benign and malignant lesions.
  
  
  RESULTS
  The apparent diffusion coefficient values for the malignant nodules were significantly lower than those of the benign nodules. The area under the curve values for T(2)W imaging combined with DWI and T(2)W imaging alone were 0.991 and 0.884, respectively.
  
  
  CONCLUSIONS
  T(2)W combined with DWI provides a powerful tool for noninvasive differentiation between malignant and benign prostatic hyperplasia nodules in the prostatic TZ.
authors.affiliation: Department of Radiology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le Western Road, Xi'an 710032, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ren
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Jinsong
authors.initials: J
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Mengqi
authors.initials: M
authors.lastname: Wei
authors.forename: Yali
authors.initials: Y
authors.lastname: Ge
authors.forename: Yi
authors.initials: Y
authors.lastname: Huan
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Larson
authors.forename: Zhuoli
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001706:Biopsy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity