title: GSTT1 null genotype distribution in the Kumaun region of northern India.
abstract: Glutathione S-transferases (GSTs) constitute a multigene family of multifunctional phase II metabolic enzymes. GSTT1, an important member of this group has a wide range of substrates including carcinogens. Total homozygous deletion or null genotype resulting in total lack of enzyme activity exists in populations for this enzyme. Since the null genotype may contribute to lower detoxification of carcinogens, this genotype is expected to increase cancer risk. The frequency of the GSTT1 null genotype is known to vary significantly among populations. However, little is known about its distribution in the hilly Kumaun region of northern India. Therefore, in this study, we determined the prevalence of the GSTT1 null polymorphism in the Kumaun popilation by conducting duplex PCR in 365 voluntary healthy individuals. The GSTT1 null genotype was detected in 18.4% of the individuals. Since GSTs play significant role in xenobiotic metabolism, the present data on GSTT1 genotype distribution should contribute in understanding genetic association with cancer risk in this understudied population.
authors.affiliation: Institute of Allied Health (Paramedical) Services, Education and Training, Govt. Medical College, Uttarakhand, India. arundhatis5@rediffmail.com
authors.forename: Arundhati
authors.initials: A
authors.lastname: Bag
authors.forename: Saloni
authors.initials: S
authors.lastname: Upadhyay
authors.forename: Lalit M
authors.initials: LM
authors.lastname: Jeena
authors.forename: Princi
authors.initials: P
authors.lastname: Pundir
authors.forename: Narayan S
authors.initials: NS
authors.lastname: Jyala
mesh_terms: D000293:Adolescent; D000328:Adult; D016001:Confidence Intervals; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase