title: Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?
abstract: Antigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross-present has been thought of as a feature of specialized DC subsets. Emerging data, however, suggest that the cross-presenting ability of each DC subset is tuned by and dependent on several factors, such as DC location and activation status, and the type of antigen and inflammatory signals. Thus, we argue that capacity of cross-presentation is not an exclusive trait of one or several distinct DC subtypes, but rather a common feature of the DC family in both mice and humans. Understanding DC subset activation and antigen-presentation pathways might yield improved tools and targets to exploit the unique cross-presenting capacity of DCs in immunotherapy.
authors.affiliation: Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Tumor Immunology Laboratory, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands.
authors.forename: Stefan
authors.initials: S
authors.lastname: Nierkens
authors.forename: Jurjen
authors.initials: J
authors.lastname: Tel
authors.forename: Edith
authors.initials: E
authors.lastname: Janssen
authors.forename: Gosse J
authors.initials: GJ
authors.lastname: Adema
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology; D045142:Cross-Priming / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans
keywords: antigen presentation; cross-presentation; dendritic cell subsets; immunotherapy
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