title: Immunomodulatory effects of a 3.2kDa polypeptide from velvet antler of Cervus nippon Temminck.
abstract: The objective of this study was to evaluate the immunomodulatory effects of a native 3.2kDa polypeptide of velvet antler from sika deer (nVAP32) on BALB/c mice immunocytes. In vitro tests showed that nVAP32 significantly stimulated splenocyte proliferation and enhanced the NK cytotoxicity and CD4(+)/CD8(+) cell subpopulations. Also, nVAP32 demonstrated a significant capacity in up- and down-regulating the expression of Th1- and Th2-related cytokines respectively. These results indicated that nVAP32 might have potential immunomodulatory effects on the immune system of mice and the further investigation on in vivo effects is qualified.
authors.affiliation: Department of Food Science and Engineering, Liaoning Medical University, No. 5-48 Renmin Street, Jinzhou 121001, China.
authors.forename: Enhui
authors.initials: E
authors.lastname: Zha
authors.forename: Xingxia
authors.initials: X
authors.lastname: Li
authors.forename: Dandan
authors.initials: D
authors.lastname: Li
authors.forename: Xuesong
authors.initials: X
authors.lastname: Guo
authors.forename: Shenyang
authors.initials: S
authors.lastname: Gao
authors.forename: Xiqing
authors.initials: X
authors.lastname: Yue
mesh_terms: D000818:Animals; D000999:Antlers; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology; D003670:Deer; D007155:Immunologic Factors / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D010455:Peptides