title: The Prostate Cancer Patient Had Higher C-Reactive Protein Than BPH Patient.
abstract: OBJECTIVE
  C-reactive protein (CRP) is a general marker for inflammation and it has been associated with prostate cancer. We hypothesized that a correlation may exist between CRP and prostate cancer in patients undergoing transrectal biopsy of the prostate because of rising prostate-specific antigen (PSA) levels.
  
  
  METHODS
  From January 2009 to March 2012, we retrospectively reviewed 710 patients who visited our urology department and were diagnosed as having a PSA value over 4.0 ng/mL. Patients with acute infections, rheumatoid arthritis, gout, asthma, chronic lung disease, myocardial infarction, or apoplexy and those who had taken nonsteroidal anti-inflammatory drugs were exempted from the research because these variables could have impacted CRP. After we applied the exclusion criteria, we selected 63 patients with prostate cancer and 140 patients with benign prostatic hyperplasia (BPH).
  
  
  RESULTS
  A total of 203 patients were observed: 140 patients had BPH, and 63 patients had prostate cancer. Prostate cancer patients were divided into two groups by tumor-node-metastasis classification. The patients below T2 were group A, and those above T3 were group B. The natural logarithm of C-reactive protein (lnCRP) differed between the BPH group and the prostate cancer group. The lnCRP also differed between the BPH group and prostate cancer groups A and B (p<0.05).
  
  
  CONCLUSIONS
  The serum CRP level of the prostate cancer group was higher than that of the BPH group. Inflammation may be correlated with prostate cancer according to the serum CRP level.
authors.affiliation: Department of Urology, Ewha Womans University School of Medicine, Seoul, Korea.
authors.forename: Youngjun
authors.initials: Y
authors.lastname: Kim
authors.forename: Yongseok
authors.initials: Y
authors.lastname: Jeon
authors.forename: Hana
authors.initials: H
authors.lastname: Lee
authors.forename: Donghyun
authors.initials: D
authors.lastname: Lee
authors.forename: Bongsuk
authors.initials: B
authors.lastname: Shim
keywords: C-reactive protein; Prostate-specific antigen; Prostatic neoplasms
references.citation: BJU Int. 2002 Mar;89(4):396-9
references.pmid: 11872031
references.citation: J Transl Med. 2011 Sep 26;9:162
references.pmid: 21943235
references.citation: Cancer Biomark. 2011-2012;10(2):91-9
references.pmid: 22430136
references.citation: Urology. 2011 Nov;78(5):1131-5
references.pmid: 22054387
references.citation: J Urol. 2004 Feb;171(2 Pt 2):S30-4; discussion S35
references.pmid: 14713750
references.citation: BJU Int. 2005 May;95(7):961-2
references.pmid: 15839913
references.citation: Cancer Res. 2004 May 1;64(9):3334-43
references.pmid: 15126378
references.citation: Nat Rev Urol. 2011 Oct 25;8(12):659-66
references.pmid: 22025173
references.citation: J Epidemiol. 2011;21(3):161-8
references.pmid: 21368452
references.citation: Biomed Pharmacother. 2012 Jul;66(5):330-3
references.pmid: 22739042
references.citation: J Urol. 2004 Feb;171(2 Pt 2):S36-40
references.pmid: 14713751
references.citation: Cancer. 2008 Jun;112(11):2377-83
references.pmid: 18428198
references.citation: Prostate Cancer Prostatic Dis. 2011 Jun;14(2):122-8
references.pmid: 21358753
references.citation: Oncol Lett. 2012 May;3(5):1166-1170
references.pmid: 22783412