title: Hemolytic disease of the fetus and newborn caused by anti-E.
abstract: OBJECTIVE
  Maternal allo-antibody production is stimulated when fetal red blood cells are positive for an antigen absent on the mother's red cells. The maternal IgG antibodies produced will pass through the placenta and attack fetal red cells carrying the corresponding antigen. Allo-immune hemolytic disease of the fetus and newborn caused by anti-E rarely occurs.
  
  
  METHODS
  We report two cases of anti-E hemolytic diseases in neonates. One of the neonates had severe hemolysis presenting with severe anemia, thrombocytopenia, and conjugated hyperbilirubinemia, while the other had moderate anemia and unconjugated hyperbilrubinemia. Although both the neonates were treated by phototherapy and intravenous immunoglobulin, one of them received double volume exchange transfusion.
  
  
  CONCLUSIONS
  There appeared to be an increase in the occurrence of hemolytic disease of the fetus and newborn caused by Rh antibodies other than anti-D. In this case report, both patients presented with anemia and hyperbilirubinemia but were successfully treated, with a favorable outcome.
authors.affiliation: Department of Hematology and Transfusion Medicine Unit, School of Medical Sciences, Universiti Sains Malaysia, Health Campus 16150 Kubang Kerian, Kelantan, Malaysia.
authors.forename: Adiyyatu Sa'idu
authors.initials: AS
authors.lastname: Usman
authors.forename: Rapiaah
authors.initials: R
authors.lastname: Mustaffa
authors.forename: Noraida
authors.initials: N
authors.lastname: Ramli
authors.forename: Sirajo A
authors.initials: SA
authors.lastname: Diggi
keywords: Allo-antibody; anti-E; hemolytic disease of the fetus and newborn
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