title: Adipose tissue fatty acid composition in Greek patients with breast cancer versus those with benign breast tumors.
abstract: BACKGROUND
  Fatty acid composition of adipose tissue is a most reliable biomarker of long-term dietary fatty acid intake. Few studies have implemented biomarkers of fatty acid intake in relation to breast cancer. In this study the relation between adipose tissue composition and breast cancer was investigated.
  
  
  METHODS
  Fatty acid composition in breast and buttock adipose tissue from 94 Greek women with breast cancer and 57 with benign breast tumors was determined. Multivariate analysis was performed to determine the association between fatty acid groups and breast cancer risk.
  
  
  RESULTS
  In pre-menopausal women, elevated total polyunsaturated fatty acids (PUFA) in breast adipose tissue and N-3 PUFA in buttock adipose tissue were associated with reduced odds of breast cancer (odds ratio, OR=0.19; 95% confidence interval, CI=0.05-0.76, p<0.02 and OR=0.02; 95% CI=0.0009-0.36, p<0.009).
  
  
  CONCLUSIONS
  Adipose total PUFA and N-3 PUFA were inversely-related to breast cancer risk in Greek pre-menopausal women. These results may have specific impact on habitual fat intake recommendations.
authors.affiliation: Department of Surgical Oncology, Medical School of Crete University Hospital, Heraklion, Greece. debree@edu.uoc.gr
authors.forename: Eelco
authors.initials: E
authors.lastname: De Bree
authors.forename: George
authors.initials: G
authors.lastname: Mamalakis
authors.forename: Elias
authors.initials: E
authors.lastname: Sanidas
authors.forename: Christos
authors.initials: C
authors.lastname: Hatzis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Askoxylakis
authors.forename: Markos
authors.initials: M
authors.lastname: Daskalakis
authors.forename: Vasileios
authors.initials: V
authors.lastname: Charalampakis
authors.forename: George
authors.initials: G
authors.lastname: Tsibinos
authors.forename: Dimitris D
authors.initials: DD
authors.lastname: Tsiftsis
authors.forename: Anthony
authors.initials: A
authors.lastname: Kafatos
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000378:metabolism* / Q000473:pathology; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002081:Buttocks / Q000473:pathology; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D018226:Fibroadenoma / Q000378:metabolism* / Q000473:pathology; D006115:Greece; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010212:Papilloma / Q000378:metabolism* / Q000473:pathology; D017697:Premenopause; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D005227:Fatty Acids