title: CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group.
abstract: The CuCl catalyzed direct trifluoromethylation of sp(2) C-H bonds has been realized, using the Togni reagent as the CF3 source. This reaction achieves the goal of regio-selectively converting C-H into C-CF3 with ecological and readily available starting materials.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Shangjun
authors.initials: S
authors.lastname: Cai
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Zelin
authors.initials: Z
authors.lastname: Sun
authors.forename: Chanjuan
authors.initials: C
authors.lastname: Xi
mesh_terms: D000577:Amides / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry; D008745:Methylation; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000577:Amides; D001555:Benzene Derivatives; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D003300:Copper; C029892:cupric chloride