title: Amplitude-based data selection for optimal retrospective reconstruction in micro-SPECT.
abstract: Respiratory motion can blur the tomographic reconstruction of positron emission tomography or single-photon emission computed tomography (SPECT) images, which subsequently impair quantitative measurements, e.g. in the upper abdomen area. Respiratory signal phase-based gated reconstruction addresses this problem, but deteriorates the signal-to-noise ratio (SNR) and other intensity-based quality measures. This paper proposes a 3D reconstruction method dedicated to micro-SPECT imaging of mice. From a 4D acquisition, the phase images exhibiting motion are identified and the associated list-mode data are discarded, which enables the reconstruction of a 3D image without respiratory artefacts. The proposed method allows a motion-free reconstruction exhibiting both satisfactory count statistics and accuracy of measures. With respect to standard 3D reconstruction (non-gated 3D reconstruction) without breathing motion correction, an increase of 14.6% of the mean standardized uptake value has been observed, while, with respect to a gated 4D reconstruction, up to 60% less noise and an increase of up to 124% of the SNR have been demonstrated.
authors.affiliation: INRIA Sophia Antipolis, Méditerranée, Sophia Antipolis, France. Marine.Breuilly@inria.fr
authors.forename: M
authors.initials: M
authors.lastname: Breuilly
authors.forename: G
authors.initials: G
authors.lastname: Malandain
authors.forename: J
authors.initials: J
authors.lastname: Guglielmi
authors.forename: R
authors.initials: R
authors.lastname: Marsault
authors.forename: T
authors.initials: T
authors.lastname: Pourcher
authors.forename: P R
authors.initials: PR
authors.lastname: Franken
authors.forename: J
authors.initials: J
authors.lastname: Darcourt
mesh_terms: D000818:Animals; D005260:Female; D021621:Imaging, Three-Dimensional / Q000379:methods*; D051379:Mice; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology; D051381:Rats; D012119:Respiration; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*