title: Sensitivity and specificity of proposed DSM-5 criteria for autism spectrum disorder in toddlers.
abstract: Autism spectrum disorder (ASD) diagnosis is based on behavioral presentation; changes in conceptual models or defining behaviors may significantly impact diagnosis and uptake of ASD-specific interventions. The literature examining impact of DSM-5 criteria is equivocal. Toddlers may be especially vulnerable to the stringent requirements of impairment in all three social-communication symptoms and two restricted/repetitive symptoms. Receiver operating characteristic (ROC) curves identified optimal cutoffs for sums of ADOS and ADI-R criteria mapped to each criterion for 422 toddlers. The optimal modification of DSM-5 criteria (sensitivity = 0.93, specificity = 0.74) required meeting the ROC-determined cutoffs for 2/3 Domain A criteria and 1 point for 1/4 Domain B criteria. This modification will help insure that ASD is identified accurately in young children, facilitating ASD-specific early intervention.
authors.affiliation: Department of Psychology, University of Connecticut, Unit 1020, Storrs, CT, USA.
authors.forename: Marianne L
authors.initials: ML
authors.lastname: Barton
authors.forename: Diana L
authors.initials: DL
authors.lastname: Robins
authors.forename: Dasal
authors.initials: D
authors.lastname: Jashar
authors.forename: Laura
authors.initials: L
authors.lastname: Brennan
authors.forename: Deborah
authors.initials: D
authors.lastname: Fein
mesh_terms: D002659:Child Development Disorders, Pervasive / Q000175:diagnosis*; D002675:Child, Preschool; D039721:Diagnostic and Statistical Manual of Mental Disorders; D018479:Early Intervention, Educational; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires
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