title: Type 2 innate lymphocytes in allergic airway inflammation.
abstract: CD4(+) T helper-2 (Th2) cells, which produce a unique profile of IL-4, IL-5 and IL-13 pro-inflammatory cytokines, are thought to be central in the orchestration and amplification of allergic asthma. However, a novel non-T/non-B lymphoid cell population, named type 2 innate lymphocytes (ILC2s), that produces high amounts of IL-5 and IL-13 was recently discovered. Unlike Th2 cells, these ILC2s are not antigen-restricted and are activated by epithelial cell-derived cytokines IL-25 and IL-33. In this review, we will focus on recent studies, mainly involving allergen-based mouse models, that have provided evidence for a significant contribution of ILC2 to allergic airway information.
authors.affiliation: Department of Pulmonary Medicine, Erasmus MC Rotterdam, Room Ee2251, PO Box 2040, NL 3000, CA Rotterdam, The Netherlands. r.kleinwolterink@erasmusmc.nl
authors.forename: Roel G J
authors.initials: RG
authors.lastname: Klein Wolterink
authors.forename: Rudi W
authors.initials: RW
authors.lastname: Hendriks
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008214:Lymphocytes / Q000502:physiology*; D020545:Respiratory Mucosa / Q000276:immunology*
chemical_list: D000485:Allergens; D016207:Cytokines
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