title: Premixed injectable calcium phosphate cement with excellent suspension stability.
abstract: Premixed injectable calcium phosphate cement (p-ICPC) pastes have advantages over aqueous injectable calcium phosphate cement (a-ICPC) because p-ICPC remain stable during storage and harden only after placement into the defect. This paper focused on the suspension stability of p-ICPC paste by using fumed silica as a stabilizing agent and propylene glycol (PEG) as a continuous phase. Multiple light scanning techniques were first applied to evaluate the suspension stability. The results indicated that fumed silica effectively enhanced the suspension stability of p-ICPC pastes. The stabilizing effect of fumed silica results from the network structure formed in PEG because of its thixotropy. The p-ICPC could be eventually hydrated to form hydroxyapatite under aqueous circumstances by the unique replacement between water and PEG. p-ICPC (1) not only possesses proper thixotropy and compressive strength but has good injectability as well. p-ICPC (1) was cytocompatible and had no adverse effect on the attachment and proliferation of MG-63 cells in vitro. These observations may have applicability to the development of other nonaqueous injectable biomaterials for non-immediate filling and long-term storage.
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. chenfangping06@yahoo.com.cn
authors.forename: Fangping
authors.initials: F
authors.lastname: Chen
authors.forename: Yuhao
authors.initials: Y
authors.lastname: Mao
authors.forename: Changsheng
authors.initials: C
authors.lastname: Liu
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000502:physiology; D001843:Bone Cements / Q000737:chemistry* / Q000493:pharmacokinetics; D002130:Calcium Phosphates / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D011232:Chemical Precipitation; D019245:Compressive Strength; D004355:Drug Stability; D007267:Injections; D008422:Materials Testing / Q000379:methods; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects / Q000502:physiology; D012212:Rheology; D013535:Suspensions; D055682:Viscoelastic Substances / Q000737:chemistry
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D013535:Suspensions; D055682:Viscoelastic Substances; C020243:calcium phosphate
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