title: Leptin and cancer: Pathogenesis and modulation.
abstract: Leptin, a product of Ob gene from adipocytes regulates appetite, energy expenditure and body mass composition by decreasing orexigenic and increasing anorexigenic neuropeptide release from hypothalamus. Research over the past few years have suggested leptin/leptin receptor dysregulation to have a role in the development of a large variety of malignancies like breast ca, thyroid ca, endometrial ca and gastrointestinal malignancies, predominantly through JAK/STAT pathway which modulates PI3K/AKT3 signaling, ERK1/2 signaling, expression of antiapoptotic proteins (like XIAP), systemic inflammation (TNF-α, IL6), angiogenic factors (VEGF) and hypoxia inducible factor-1a (HIF-1a) expression. In this review, the current understanding of leptin's role in carcinogenesis has been elaborated. Also a few agents modulating leptin signaling to inhibit cancer cell growth has been described.
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research Kolkata, Kolkata, India.
authors.forename: Deep
authors.initials: D
authors.lastname: Dutta
authors.forename: Sujoy
authors.initials: S
authors.lastname: Ghosh
authors.forename: Kaushik
authors.initials: K
authors.lastname: Pandit
authors.forename: Pradip
authors.initials: P
authors.lastname: Mukhopadhyay
authors.forename: Subhankar
authors.initials: S
authors.lastname: Chowdhury
keywords: Breast cancer; colorectal cancer; hepatocellular cancer; leptin; thyroid cancer
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