title: Development of a guided bone regeneration device using salicylic acid-poly(anhydride-ester) polymers and osteoconductive scaffolds.
abstract: Successful repair of craniofacial and periodontal tissue defects ideally involves a combined therapy that includes inflammation modulation, control of soft tissue infiltration, and bone regeneration. In this study, an anti-inflammatory polymer, salicylic acid-based poly(anhydride-ester) (SAPAE) and a three-dimensional osteoconductive ceramic scaffold were evaluated as a combined guided bone regeneration (GBR) system for concurrent control of inflammation, soft tissue ingrowth, and bone repair in a rabbit cranial defect model. At time periods of 1, 3, and 8 weeks, five groups were compared: (1) scaffolds with a solid ceramic cap (as a GBR structure); (2) scaffolds with no cap; (3) scaffolds with a poly(lactide-glycolide) cap; (4) scaffolds with a slow release SAPAE polymer cap; and (5) scaffolds with a fast release SAPAE polymer cap. Cellular infiltration and bone formation in these scaffolds were evaluated to assess inflammation and bone repair capacity of the test groups. The SAPAE polymers suppressed inflammation and displayed no deleterious effect on bone formation. Additional work is warranted to optimize the anti-inflammatory action of the SAPAE, GBR suppression of soft tissue infiltration, and stimulation of bone formation in the scaffolds and create a composite device for successful repair of craniofacial and periodontal tissue defects.
authors.affiliation: University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Department of Biochemistry & Molecular Biology, Newark, NJ.
authors.forename: Ashley
authors.initials: A
authors.lastname: Mitchell
authors.forename: Brian
authors.initials: B
authors.lastname: Kim
authors.forename: Jessica
authors.initials: J
authors.lastname: Cottrell
authors.forename: Sabrina
authors.initials: S
authors.lastname: Snyder
authors.forename: Lukasz
authors.initials: L
authors.lastname: Witek
authors.forename: John
authors.initials: J
authors.lastname: Ricci
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Uhrich
authors.forename: J Patrick
authors.initials: JP
authors.lastname: O'Connor
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011817:Rabbits; D012886:Skull / Q000293:injuries* / Q000502:physiology; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000812:Anhydrides; D018786:Bone Substitutes; D011108:Polymers; D019158:N-Acetylneuraminic Acid
keywords: bone regeneration; guided bone regeneration; inflammation; salicylic acid-based poly(anhydride-ester) polymer; tissue engineering