title: Expeditious synthesis of bacterial, rare sugar building blocks to access the prokaryotic glycome.
abstract: Bacteria have unusual glycans which are not accessible by isolation. Herein, we describe a general and divergent strategy for the synthesis of the rare, bacterial deoxy amino hexopyranoside building blocks from d-mannose. The methodology is applied to the first total synthesis of the l-serine linked trisaccharide of Neisseria meningitidis.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
authors.forename: Madhu
authors.initials: M
authors.lastname: Emmadi
authors.forename: Suvarn S
authors.initials: SS
authors.lastname: Kulkarni
mesh_terms: D002236:Carbohydrate Conformation; D008969:Molecular Sequence Data; D009345:Neisseria meningitidis / Q000737:chemistry*; D012694:Serine / Q000737:chemistry; D014312:Trisaccharides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D014312:Trisaccharides; D012694:Serine