title: Function of feline signaling lymphocyte activation molecule as a receptor of canine distemper virus.
abstract: Morbilliviruses use signaling lymphocyte activation molecule (SLAM) as a receptor for their entry to cells. In this study, a complete gene encoding SLAM of a domestic cat was identified. The identity of feline SLAM with canine one was 73%, and feline SLAM formed the same cluster with those of carnivores. Furthermore, feline cell expressing feline SLAM supported growth of canine distemper virus (CDV) as well as that expressing canine one. These results indicated that feline SLAM can function as a receptor for morbilliviruses, and our established feline cells that express feline SLAM might be useful for analysis of morbilliviruses originated from felids.
authors.affiliation: Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Hara
authors.forename: Junko
authors.initials: J
authors.lastname: Suzuki
authors.forename: Keita
authors.initials: K
authors.lastname: Noguchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Terada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimoda
authors.forename: Takuya
authors.initials: T
authors.lastname: Mizuno
authors.forename: Ken
authors.initials: K
authors.lastname: Maeda
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D002415:Cats; D016000:Cluster Analysis; D017931:DNA Primers / Q000235:genetics; D004217:Distemper Virus, Canine / Q000502:physiology*; D005254:Feline Panleukopenia / Q000503:physiopathology* / Q000821:virology*; D005434:Flow Cytometry; D008969:Molecular Sequence Data; D010802:Phylogeny; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D013045:Species Specificity; D053586:Virus Internalization
chemical_list: D015703:Antigens, CD; D017931:DNA Primers; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1