title: Genetic animal models of preconditioning.
abstract: The preconditioning phenomena have been well established in heart as well as brain. In this review, we detail some of the original studies on preconditioning as well as studies from our lab using rodents and a genetic model system (fruit fly). We have used Drosophila in our lab to solve some of the questions related to tolerance or susceptibility to hypoxia. We believe that these pro-survival strategies and genetic pathways help us understand some of the preconditioning mechanisms that protect the brain from ischemia or ischemia.
authors.affiliation: Department of Pediatrics (Section of Respiratory Medicine), University of California-San Diego, La Jolla, CA 92093, USA.
authors.forename: Priti
authors.initials: P
authors.lastname: Azad
authors.forename: Gabriel G
authors.initials: GG
authors.lastname: Haddad
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000235:genetics* / Q000628:therapy*; D004195:Disease Models, Animal; D004331:Drosophila melanogaster; D019194:Ischemic Preconditioning; D051379:Mice; D051381:Rats
keywords: Preconditioning; fruit flies; genetic model; hypoxia tolerance
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