title: Synthesis of the griseusin B framework via a one-pot annulation-methylation-double deprotection-spirocyclization sequence.
abstract: A highly convergent synthesis of the griseusin B scaffold is described. The key step involves an efficient one-pot Hauser-Kraus annulation-methylation-double deprotection-spirocyclization sequence that directly affords the target parent tetracyclic ring system.
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
authors.forename: Briar J
authors.initials: BJ
authors.lastname: Naysmith
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D008745:Methylation; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D001688:Biological Products; D009285:Naphthoquinones; D013141:Spiro Compounds; C012339:griseusin