title: Biochemical indicator of sickle cell disease: preliminary report from India.
abstract: Blood biochemistry has significant effect on pathophysiology of human body. Recently few studies found the association of biochemical abnormalities in sickle cell patients. Sickle cell disease showed clinical variability where African ancestors have severe phenotype than Indian sicklers. Our aim was to evaluate the biochemicals in sickle cell patients and their effect on severity. Here we present the comparative biochemical levels in sickle cell patients as well as controls. Sickle cell patients diagnosed by HPLC and biochemical analysis done by Beckman-auto analyzer. T test applied for statistical analysis. Result showed the renal abnormality lesser in patients and related biochemical within the normal range and statistically not significant. Electrolytes, hepatic enzymes, alkaline phosphatase and glucose were elevated and statistically significant (P value <0.05). Observation of the study concludes the biochemical abnormality play a significant role in sickle cell patient's physiopathology and can be used to management of the disease.
authors.affiliation: Department of Hematology, All India Institute of Medical Sciences (AIIMS), I.R.C.H. Building (1st Floor), Ansari Nagar, New Delhi, 110 029 India.
authors.forename: S
authors.initials: S
authors.lastname: Pandey
authors.forename: A
authors.initials: A
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Dahia
authors.forename: V
authors.initials: V
authors.lastname: Shah
authors.forename: V
authors.initials: V
authors.lastname: Sharma
authors.forename: R M
authors.initials: RM
authors.lastname: Mishra
authors.forename: Sw
authors.initials: S
authors.lastname: Pandey
authors.forename: R
authors.initials: R
authors.lastname: Saxena
keywords: Biochemical; High performance liquid chromatography; Sickle cell anaemia
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