title: HIV/HBV coinfection: serological control and therapeutic strategies.
abstract: OBJECTIVE
  The evolution and prognosis of patients co-infected by human immunodeficiency virus (HIV) and hepatitis B (HBV) is not well know. This study describes the treatment and serological, virological and biochemical and elastographic responses of HIV and HBV-coinfected patients.
  
  
  METHODS
  A descriptive, retrospective study of all the HIV/HBV-coinfected patients seen in a specialized HIV department between 1 January 2007 and 30 November 2008 was performed. Virological and serological determinations of HIV and HBV infections as well as CD4 lymphocytes and transaminases prior to antiretroviral treatment and at the time of analysis were obtained.
  
  
  RESULTS
  A total of 54 (5.4%) cases of HIV/HBV coinfection were identified. The median nadir and current CD4 were 179 and 437 cells/L, respectively. There was undetectable RNA-HIV in 70%. There were 52 patients (96.3%) who followed active drugs treatment against HBV. After treatment, 68.8% had HBeAg negative result, with 81.6% virologic response. The HBsAg became negative in 10.4%. ALT was normal in 75.5%. FibroScan(®) was performed in 30 (55.6%) patients, yielding a median of 7.0kPa.
  
  
  CONCLUSIONS
  The results obtained suggest a good serological, virological and biochemical control of HIV/HBV-coinfected patients with treatments recommended by clinical guidelines.
authors.affiliation: Servicio de Urgencias, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España. ruizpedroc@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Ruiz-Artacho
authors.forename: M J
authors.initials: MJ
authors.lastname: Téllez-Molina
authors.forename: J
authors.initials: J
authors.lastname: Vergas-García
authors.forename: K
authors.initials: K
authors.lastname: Altali-Alhames
authors.forename: V
authors.initials: V
authors.lastname: Estrada-Pérez
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Cruz-Pérez
mesh_terms: D000328:Adult; D060085:Coinfection / Q000097:blood* / Q000188:drug therapy*; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012698:Serologic Tests
keywords: Antiretroviral therapy; Coinfección; Coinfection; HIV; Hepatitis B virus; Terapia antirretroviral; VIH; Virus de la hepatitis B