title: Plasma TGF-β1, MMP-1 and MMP-3 Levels in Chronic Pancreatitis.
abstract: Chronic pancreatitis (CP) presenting clinically with upper abdominal pain, as well as exocrine and endocrine insufficiencies, is characterized by irreversible morphological and functional alterations in the pancreas. The objective of the present study is to investigate the plasma levels of transforming growth factor-β 1 (TGF-β1), matrix metalloproteinases MMP-1 (collagenase) and MMP-3 (stromelysin) in CP. A total of 71 CP patients and 100 control subjects were considered for the study. Plasma levels of TGF-β1, MMP-1 and MMP-3 were determined by enzyme-linked immunosorbent assay in patients and control subjects. The plasma levels of TGF-β1 and MMP-1 were significantly elevated in patients compared to control group (*P = 0.0301, **P < 0.0001). However, there was no significant difference in the plasma levels of MMP-3 between patients and controls (P = 0.3756). The elevated levels of TGF-β1 and MMP-1 may influence the inflammatory reactions by enhancing the pancreatic stellate cell activation and deposition of extracellular matrix resulting in pancreatic fibrosis. Thus, the present study highlights the role of fibrogenic cytokine marker TGF-β1 and matrix metalloproteinases in the pathogenesis of CP.
authors.affiliation: Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet Hyderabad, 500 016 India.
authors.forename: K
authors.initials: K
authors.lastname: Sri Manjari
authors.forename: Pratibha
authors.initials: P
authors.lastname: Nallari
authors.forename: A
authors.initials: A
authors.lastname: Vidyasagar
authors.forename: A
authors.initials: A
authors.lastname: Jyothy
authors.forename: A
authors.initials: A
authors.lastname: Venkateshwari
keywords: Chronic pancreatitis; Fibrosis; Matrix metalloproteinases; Pancreatic stellate cells; Transforming growth factor-β1
references.citation: J Biosci. 2009 Jun;34(2):313-20
references.pmid: 19550047
references.citation: Rocz Akad Med Bialymst. 2004;49:40-6
references.pmid: 15631312
references.citation: Clin Chem. 2000 Dec;46(12):2023-4
references.pmid: 11106348
references.citation: Z Hautkr. 1989 Sep 15;64(9):775-6, 779-81
references.pmid: 2683440
references.citation: Int J Gastrointest Cancer. 2002;31(1-3):41-6
references.pmid: 12622414
references.citation: J Cell Biol. 1993 Jul;122(1):103-11
references.pmid: 8314838
references.citation: Genes Dev. 1999 Jan 1;13(1):35-48
references.pmid: 9887098
references.citation: Pancreas. 2001 Oct;23(3):288-95
references.pmid: 11590325
references.citation: J Biol Chem. 1994 Apr 8;269(14):10551-8
references.pmid: 8144642
references.citation: World J Gastroenterol. 2007 Nov 28;13(44):5926-32
references.pmid: 17990358
references.citation: Am J Pathol. 1992 Dec;141(6):1381-96
references.pmid: 1281619
references.citation: Am J Pathol. 2002 May;160(5):1787-98
references.pmid: 12000730
references.citation: Virchows Arch. 2004 Jul;445(1):1-8
references.pmid: 15138818
references.citation: Mol Pharmacol. 2002 Jul;62(1):58-64
references.pmid: 12065755
references.citation: Gastrointest Endosc. 2007 Sep;66(3):510-2
references.pmid: 17725939
references.citation: N Engl J Med. 2000 May 4;342(18):1350-8
references.pmid: 10793168