title: Update meta-analysis on MMP-7 -181A>G polymorphism and cancer risk: evidence from 25 studies.
abstract: BACKGROUND
  The matrix metalloproteinase (MMP) can degrade various components of the extracellular matrix and its functional genetic polymorphism may be associated with cancer development. The common MMP-7 (-181A>G) genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancers. However, the association between MMP-7 (-181A>G) and cancer risk remains inconclusive.
  
  
  METHODS
  To better understand the role of MMP-7 (-181A>G) polymorphism in global cancer, we conducted this comprehensive meta-analysis encompassing 6392 cases and 7665 controls.
  
  
  RESULTS
  Overall, the MMP-7 (-181A>G) polymorphism was associated with higher cancer risk. In the stratified analyses, significant associations were found between the MMP-7 (-181A>G) polymorphism and gastric cancer, ESCC and gynecologic cancer. We also observed that the GG genotype might modulate colorectal cancer risk comparing with the AA genotype (OR=1.31[1.02-1.69]). Moreover, a significantly increased cancer risk was found among Asian populations. When stratified by study design, significantly elevated susceptibility to cancer was found among population-based studies.
  
  
  CONCLUSIONS
  These findings suggested that the MMP-7 (-181A>G) genetic polymorphism may contribute to the susceptibility of cancers, especially among Asian population.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Jilin, China.
authors.forename: Xueling
authors.initials: X
authors.lastname: Yang
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Li
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020783:Matrix Metalloproteinase 7 / Q000235:genetics*; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7