title: Incidence and mortality trends for four major cancers in the elderly and middle-aged adults: an international comparison.
abstract: BACKGROUND
  Time trends comparisons by age are important to understand the specific needs of elderly cancer patients and to improve clinical procedures. The aim is to compare 1998-2005 cancer incidence and mortality trends in Italy and the US for both sexes and for two age groups, namely 50-69 year old and 70+ year old.
  
  
  METHODS
  Cancer incidence and mortality data came from 22 Cancer Registries (CRs) of the Italian association of cancer registries (AIRTUM), while the US incidence records were provided by 13 SEER CRs and the mortality statistics provided by the WHO Database. Trends were analysed by the Joinpoint Regression Program in order to obtain Annual Percent Changes and Joinpoints.
  
  
  RESULTS
  Colorectal cancer incidence trends were favourable in the US for both sexes and in both age groups, whilst the rates increased in Italian elderly individuals and mortality rates fell markedly only in the US. For lung cancer, incidence and mortality decreased in men but increased in women in the two geographical areas. Breast cancer incidence and mortality declined both in Italy and the US for younger women, but the trends were less favourable in the Italian elderly individuals. The increase of prostate incidence slowed down and mortality diminished for every age group in the US, whilst in Italy only in the younger group.
  
  
  CONCLUSIONS
  For major cancers, the Italian elderly experienced less favourable trends than the middle-aged patients whereas, in the US, the trends were similar for both age groups and favourable also for the elderly.
authors.affiliation: IRCCS Azienda ospedaliera universitaria San Martino, IST Istituto nazionale per la ricerca sul cancro, U.O.S. Epidemiologia descrittiva (Registro tumori), Genova, Italy. alberto.quaglia1965@libero.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Quaglia
authors.forename: Roberto
authors.initials: R
authors.lastname: Lillini
authors.forename: Emanuele
authors.initials: E
authors.lastname: Crocetti
authors.forename: Carlotta
authors.initials: C
authors.lastname: Buzzoni
authors.forename: Marina
authors.initials: M
authors.lastname: Vercelli
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D007390:International Agencies; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends*; D009369:Neoplasms / Q000453:epidemiology* / Q000401:mortality*; D011379:Prognosis; D015996:Survival Rate; D014481:United States / Q000453:epidemiology