title: Epidemiology and characterization of seizures in a pedigreed baboon colony.
abstract: This study evaluated the incidence, prevalence, and clinical features of seizures in a pedigreed captive colony of baboons. The association of seizures with subspecies, age, sex, and various clinical features was assessed. Records for 1527 captive, pedigreed baboons were reviewed, and 3389 events were identified in 1098 baboons. Of these events, 1537 (45%) represented witnessed seizures, whereas the remaining 1852 presented with craniofacial trauma or episodic changes in behavior that were suggestive, but not diagnostic, of seizure activity. Seizures were generalized myoclonic or tonic-clonic, with two thirds of the events witnessed in the morning. Seizure onset occurred in adolescence (age, 5 y), with an average of 3 seizures in a lifetime. The incidence and prevalence of seizures were 2.5% and 26%, respectively, whereas the prevalence of recurrent seizures (that is, epilepsy) was 15%. Seizures were more prevalent in male baboons, which tended to present with earlier onset and more seizures over a lifetime than did female baboons. Seizures were equally distributed between the subspecies; age of onset and seizure recurrences did not differ significantly between subspecies. Clinical features including age of onset, characteristics, and diurnal presentation of seizures in baboons suggested similarities to juvenile myoclonic epilepsy in humans. Facial trauma may be useful marker for epilepsy in baboons, but its specificity should be characterized.
authors.affiliation: Department of Neurology and South Texas Comprehensive Epilepsy Center, San Antonio, TX, USA. szabo@uthscsa.edu
authors.forename: C Ákos
authors.initials: CÁ
authors.lastname: Szabó
authors.forename: Koyle D
authors.initials: KD
authors.lastname: Knape
authors.forename: M Michelle
authors.initials: MM
authors.lastname: Leland
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Cwikla
authors.forename: Sarah
authors.initials: S
authors.lastname: Williams-Blangero
authors.forename: Jeff T
authors.initials: JT
authors.lastname: Williams
mesh_terms: D000367:Age Factors; D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D015994:Incidence; D008297:Male; D008992:Monkey Diseases / Q000453:epidemiology* / Q000473:pathology*; D010215:Papio; D010375:Pedigree; D015995:Prevalence; D012189:Retrospective Studies; D012640:Seizures / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D012737:Sex Factors
references.citation: Am J Primatol. 2004 Feb;62(2):95-106
references.pmid: 14983467
references.citation: Fed Proc. 1979 Sep;38(10):2429-33
references.pmid: 39008
references.citation: Epilepsy Res. 2011 Feb;93(2-3):91-5
references.pmid: 21256716
references.citation: Mayo Clin Proc. 1996 Jun;71(6):576-86
references.pmid: 8642887
references.citation: Am J Hum Genet. 1997 Sep;61(3):489-93
references.pmid: 9326312
references.citation: Brain. 1997 Mar;120 ( Pt 3):479-90
references.pmid: 9126059
references.citation: Adv Neurol. 1975;10:107-18
references.pmid: 1146641
references.citation: Life Sci. 1967 Aug 1;6(15):1569-74
references.pmid: 4963371
references.citation: Am J Primatol. 1990;20(2):67-81
references.pmid: 31963994
references.citation: Nat Genet. 1998 Aug;19(4):366-70
references.pmid: 9697698
references.citation: Acta Neurol Scand Suppl. 1989;125:3-149
references.pmid: 2618589
references.citation: Epilepsy Res Suppl. 1992;9:141-9
references.pmid: 1363039
references.citation: Brain. 2006 May;129(Pt 5):1269-80
references.pmid: 16520331
references.citation: Epilepsia. 2009 Aug;50(8):1995-8
references.pmid: 19389147
references.citation: Epilepsy Res. 2005 Jun;65(1-2):71-80
references.pmid: 15994062
references.citation: Epilepsia. 1989;30 Suppl 4:S1-7; discussion S24-7
references.pmid: 2506006
references.citation: Lab Anim Sci. 1996 Apr;46(2):146-51
references.pmid: 8723229
references.citation: J Med Primatol. 2011 Oct;40(5):357-63
references.pmid: 21332757