title: Recent advancements in tissue engineering for stem cell-based cardiac therapies.
abstract: Advances in cardiac tissue engineering have recently focused on utilizing stem cells to regenerate infarcted and scarred myocardium. Due to their proliferative nature and tremendous potential for differentiation, stem cells are presently being investigated for clinical applications. Unfortunately, limiting factors such as massive cell death and poor retention have hampered clinical outcomes. Consequently, the development of an efficient delivery system for stem cells to the target site is essential. The use of innovative tissue engineering techniques has opened up new horizons within the field of cellular cardiomyoplasty. This paper will present a comprehensive overview of the recent advancements in stem cell technology destined for myocardial tissue repair. In addition, the multidisciplinary approach to tissue engineering presented here will provide the reader with insight into the clinical realization of cellular cardiomyoplasty.
authors.affiliation: Cardiothoracic Surgery & Surgical Research, Royal Victoria Hospital, Montreal, Quebec, Canada.
authors.forename: Alice
authors.initials: A
authors.lastname: Le Huu
authors.forename: Arghya
authors.initials: A
authors.lastname: Paul
authors.forename: Liqin
authors.initials: L
authors.lastname: Xu
authors.forename: Satya
authors.initials: S
authors.lastname: Prakash
authors.forename: Dominique
authors.initials: D
authors.lastname: Shum-Tim
mesh_terms: D000818:Animals; D002309:Cardiology / Q000639:trends; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D006801:Humans; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009206:Myocardium / Q000473:pathology; D032383:Myocytes, Cardiac / Q000473:pathology / Q000637:transplantation*; D020127:Recovery of Function; D012038:Regeneration; D044968:Regenerative Medicine / Q000639:trends; D033581:Stem Cell Transplantation / Q000639:trends; D023822:Tissue Engineering / Q000639:trends; D016896:Treatment Outcome