title: Type II secretion: the substrates that won't go away.
abstract: Type II secretion systems (T2SSs) generally release their substrates into the culture medium. A few T2SS substrates remain anchored to or bound at the surface of the bacteria after secretion. Since they handle already folded proteins, T2SSs are the best way for bacteria to target, at their surface, proteins containing a cofactor, proteins that have to be folded in the cytoplasm or in the periplasm, or multimeric proteins. However, how a T2SS deals with membrane-anchored proteins is not yet understood. While this type of protein has until now been overlooked, new proteomic approaches will facilitate its identification.
authors.affiliation: Université de Lyon, F69003, Université Lyon 1, F69622, INSA-Lyon, F69621, CNRS UMR5240, Microbiologie Adaptation et Pathogénie, 10 rue Dubois, Bât. Lwoff, 69622 Villeurbanne, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Rondelet
authors.forename: Guy
authors.initials: G
authors.lastname: Condemine
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D058947:Bacterial Secretion Systems; D002462:Cell Membrane / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017510:Protein Folding; D021381:Protein Transport
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems
keywords: Lipoprotein; Outer membrane; Secretion; Surface-associated protein; Tat signal-anchored protein; Type II secretion system