title: Posttraumatic stress disorder: neurocircuitry and implications for potential deep brain stimulation.
abstract: Posttraumatic stress disorder (PTSD) is a prevalent and highly disabling psychiatric disorder that is notoriously difficult to treat. At some point in their lifetimes, 5-8% of men, 10-14% of women, and up to a quarter of combat veterans carry this diagnosis. Despite pharmacological and behavioral therapies, up to 30% of patients are still symptomatic 10 years after initial diagnosis. Recent advances in imaging have implicated changes in the limbic and autonomic corticostriatopallidothalamocortical (CSPTC) circuitry in the pathogenesis of this disease. Deep brain stimulation modulates CSPTC circuits in movement and other neuropsychiatric disorders. In this review, we discuss the salient clinical features and neurocircuitry of PTSD and propose a neuromodulation strategy for the disorder.
authors.affiliation: Center for Neuromodulation, Department of Neurosurgery, Ohio State University, Columbus, Ohio, USA. alextaghva@gmail.com
authors.forename: Alexander
authors.initials: A
authors.lastname: Taghva
authors.forename: Chima
authors.initials: C
authors.lastname: Oluigbo
authors.forename: John
authors.initials: J
authors.lastname: Corrigan
authors.forename: Ali R
authors.initials: AR
authors.lastname: Rezai
mesh_terms: D001921:Brain / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D009415:Nerve Net / Q000502:physiology*; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*