title: The rat prefrontostriatal system analyzed in 3D: evidence for multiple interacting functional units.
abstract: Previous studies in monkeys disclosed a specific arrangement of corticostriatal projections. Prefrontal and premotor areas form dense projection fields surrounded by diffuse terminal areas extending outside the densely innervated region and overlapping with projections from other areas. In this study, the mode of prefrontostriatal innervation was analyzed in rats using a 3D approach. Following injections of tracers in defined cortical areas, 3D maps from individual cases were elaborated and combined into a global 3D map allowing us to define putative overlaps between projection territories. In addition to providing a detailed 3D mapping of the topographic representation of prefrontal cortical areas in the rat striatum, the results stress important similarities between the rodent and primate prefrontostriatal projections. They share the dual pattern of focal and diffuse corticostriatal projections. Moreover, besides segregated projections consistent with parallel processing, the interweaving of projection territories establishes specific patterns of overlaps spatially organized along the dorsoventral, mediolateral, and anteroposterior striatal axis. In particular, the extensive striatal projection fields from the prelimbic and anterior cingulate areas, which partly overlap the terminal fields from medial, orbital, and lateral prefrontal cortical areas, provide putative domains of convergence for integration between reward, cognitive, and motor processes.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale UMRs 952, Centre National de Recherche Scientifique UMR 7224, Université Pierre et Marie Curie, 75252 Paris Cedex 05, France. philippe.mailly@snv.jussieu.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Mailly
authors.forename: Verena
authors.initials: V
authors.lastname: Aliane
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Groenewegen
authors.forename: Suzanne N
authors.initials: SN
authors.lastname: Haber
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Deniau
mesh_terms: D000818:Animals; D001931:Brain Mapping; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000502:physiology*; D004569:Electroencephalography; D021621:Imaging, Three-Dimensional; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D010835:Phytohemagglutinins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010835:Phytohemagglutinins; C100156:leukoagglutinins, plants
references.citation: Brain Res Bull. 2009 Feb 16;78(2-3):69-74
references.pmid: 18950692
references.citation: J Comp Neurol. 1992 Feb 15;316(3):314-47
references.pmid: 1577988
references.citation: Nat Neurosci. 1999 May;2(5):467-72
references.pmid: 10321252
references.citation: J Neurosci. 2010 Mar 3;30(9):3499-507
references.pmid: 20203210
references.citation: J Neurosci Methods. 1980 Dec;3(2):129-49
references.pmid: 6110810
references.citation: Neuroscience. 1989;29(3):503-37
references.pmid: 2472578
references.citation: Trends Neurosci. 1990 Jul;13(7):266-71
references.pmid: 1695401
references.citation: Neuroscience. 1994 Nov;63(2):363-79
references.pmid: 7891852
references.citation: Behav Brain Res. 2003 Nov 30;146(1-2):3-17
references.pmid: 14643455
references.citation: Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8124-9
references.pmid: 18523020
references.citation: Neuroscience. 2009 Jun 2;160(4):744-54
references.pmid: 19303912
references.citation: Neurosci Biobehav Rev. 2003 Oct;27(6):555-79
references.pmid: 14599436
references.citation: Trends Neurosci. 2004 Aug;27(8):468-74
references.pmid: 15271494
references.citation: Acad Radiol. 2004 Feb;11(2):178-89
references.pmid: 14974593
references.citation: J Neurosci. 2006 Aug 9;26(32):8368-76
references.pmid: 16899732
references.citation: Brain Struct Funct. 2008 Feb;212(5):387-401
references.pmid: 18183420
references.citation: J Neurosci Methods. 2010 Dec 15;194(1):56-63
references.pmid: 20043949
references.citation: Brain Res. 1984 Nov;320(1):65-98
references.pmid: 6440660
references.citation: J Neurophysiol. 2002 Feb;87(2):1007-17
references.pmid: 11826064
references.citation: Adv Neurol. 1997;74:83-96
references.pmid: 9348404
references.citation: J Physiol. 2008 Jan 1;586(1):265-82
references.pmid: 17974593
references.citation: Neuroscience. 1987 Jan;20(1):293-303
references.pmid: 2436089
references.citation: Neurosci Lett. 2008 Feb 13;432(1):40-5
references.pmid: 18248891
references.citation: J Neurosci. 2006 Jun 7;26(23):6314-7
references.pmid: 16763039
references.citation: Neurobiol Learn Mem. 1998 Jul-Sep;70(1-2):119-36
references.pmid: 9753592
references.citation: J Comp Neurol. 2003 Dec 15;467(3):271-92
references.pmid: 14608594
references.citation: Neuroscience. 1999 Jan;88(1):119-33
references.pmid: 10051194
references.citation: J Comp Neurol. 1985 Jun 15;236(3):315-30
references.pmid: 4056098
references.citation: Curr Opin Neurobiol. 2005 Dec;15(6):638-44
references.pmid: 16271465
references.citation: Brain Res. 1978 Jan 6;139(1):43-63
references.pmid: 413609
references.citation: Eur J Neurosci. 2007 Oct;26(7):2005-24
references.pmid: 17892479
references.citation: J Neurosci. 2000 Mar 15;20(6):2369-82
references.pmid: 10704511
references.citation: J Neurosci. 2005 Apr 13;25(15):3857-69
references.pmid: 15829638
references.citation: Nat Rev Neurosci. 2006 Jun;7(6):464-76
references.pmid: 16715055
references.citation: J Comp Neurol. 2007 May 1;502(1):86-112
references.pmid: 17335041
references.citation: Trends Neurosci. 1994 Feb;17(2):52-7
references.pmid: 7512768
references.citation: J Neurosci. 1992 Jun;12(6):2079-103
references.pmid: 1607929
references.citation: Trends Neurosci. 1990 Jul;13(7):254-8
references.pmid: 1695399
references.citation: J Neurosci. 1995 Jun;15(6):4449-63
references.pmid: 7790919
references.citation: J Struct Biol. 1996 Jan-Feb;116(1):71-6
references.pmid: 8742726
references.citation: Science. 1994 Oct 21;266(5184):458-61
references.pmid: 7939688
references.citation: J Comp Neurol. 1996 Oct 28;374(4):578-92
references.pmid: 8910736