title: A sleep state during C. elegans development.
abstract: Caenorhabditis elegans is the simplest animal shown to sleep. It sleeps during lethargus, a larval transition stage. Behavior during lethargus has the sleep properties of a specific quiescent posture and elevated arousal threshold that are reversible to strong stimulation and of increased sleep drive following sleep deprivation. Genetic similarities between sleep regulation during C. elegans lethargus and sleep regulation in other animals point to a sleep state that was an evolutionarily ancestor to sleep both in C. elegans and other animals. Recent publications have shed light on key questions in sleep biology: First, How is sleep regulated? Second, How is sensory information gated during sleep? Third, How is sleep homeostasis mediated? Fourth, What is the core function of sleep?
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, 462 Stemmler Hall, 415 Curie Boulevard, Philadelphia, PA 19104, United States.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Nelson
authors.forename: David M
authors.initials: DM
authors.lastname: Raizen
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D017173:Caenorhabditis elegans / Q000502:physiology*; D007814:Larva / Q000502:physiology; D008675:Metamorphosis, Biological / Q000502:physiology*; D012890:Sleep / Q000502:physiology*
references.citation: J Neurosci Methods. 2011 Sep 30;201(1):78-88
references.pmid: 21801751
references.citation: Curr Biol. 2011 May 24;21(10):825-34
references.pmid: 21549604
references.citation: J Exp Biol. 2008 Dec;211(Pt 23):3703-11
references.pmid: 19011210
references.citation: J Gen Microbiol. 1964 Jun;35:437-45
references.pmid: 14188770
references.citation: Nat Neurosci. 2007 Sep;10(9):1160-7
references.pmid: 17694052
references.citation: Prog Neurobiol. 2000 Jul;61(4):339-51
references.pmid: 10727779
references.citation: Worm. 2012 Jan 1;1(1):12-4
references.pmid: 24058817
references.citation: Cell Metab. 2012 May 2;15(5):713-24
references.pmid: 22560223
references.citation: Nature. 1998 Sep 3;395(6697):78-82
references.pmid: 9738501
references.citation: Nature. 2005 Oct 27;437(7063):1257-63
references.pmid: 16251950
references.citation: PLoS Biol. 2008 Apr 29;6(4):e106
references.pmid: 18447584
references.citation: Physiol Behav. 2011 Jun 1;103(3-4):315-20
references.pmid: 21315097
references.citation: Curr Biol. 2011 Dec 20;21(24):R983-4
references.pmid: 22192827
references.citation: Trends Neurosci. 2008 Jul;31(7):371-6
references.pmid: 18538867
references.citation: Curr Biol. 2011 Dec 20;21(24):2033-45
references.pmid: 22137474
references.citation: Sleep Med Rev. 2006 Feb;10(1):49-62
references.pmid: 16376591
references.citation: PLoS One. 2013;8(1):e54528
references.pmid: 23349920
references.citation: Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20479-84
references.pmid: 23185015
references.citation: Acta Physiol (Oxf). 2008 Jan;192(1):19-28
references.pmid: 18171426
references.citation: Behav Brain Res. 1983 Jun;8(3):351-60
references.pmid: 6871020
references.citation: Proc Natl Acad Sci U S A. 1971 Sep;68(9):2112-6
references.pmid: 5002428
references.citation: Science. 2008 Jul 18;321(5887):372-6
references.pmid: 18635795
references.citation: Neuron. 2002 Dec 19;36(6):1079-89
references.pmid: 12495623
references.citation: Curr Biol. 2002 Jan 22;12(2):R46-7
references.pmid: 11818075
references.citation: Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2613-8
references.pmid: 22308351
references.citation: Dev Biol. 2006 Jan 1;289(1):30-43
references.pmid: 16300753
references.citation: J Neurosci. 2011 Nov 2;31(44):15932-43
references.pmid: 22049436
references.citation: Nature. 2002 May 16;417(6886):287-91
references.pmid: 12015603
references.citation: Curr Biol. 2013 Mar 18;23(6):501-6
references.pmid: 23477722
references.citation: Annu Rev Neurosci. 2001;24:1091-119
references.pmid: 11520929
references.citation: Nature. 2005 Oct 27;437(7063):1254-6
references.pmid: 16251949
references.citation: Cell Metab. 2008 Mar;7(3):249-57
references.pmid: 18316030
references.citation: Brain Res Bull. 2006 Apr 14;69(3):223-43
references.pmid: 16564418
references.citation: Science. 1999 Nov 5;286(5442):1141-6
references.pmid: 10550049
references.citation: Philos Trans R Soc Lond B Biol Sci. 1986 Nov 12;314(1165):1-340
references.pmid: 22462104
references.citation: Int J Endocrinol. 2010;2010:759234
references.pmid: 20628523
references.citation: Science. 2001 Dec 21;294(5551):2511-5
references.pmid: 11752569
references.citation: Science. 2011 Jun 24;332(6037):1576-81
references.pmid: 21700878
references.citation: Dev Cell. 2005 Feb;8(2):287-95
references.pmid: 15691769
references.citation: Curr Opin Neurobiol. 1994 Aug;4(4):550-6
references.pmid: 7812144
references.citation: Nat Neurosci. 2007 Oct;10(10):1300-7
references.pmid: 17891142
references.citation: Sleep. 2002 Feb 1;25(1):68-87
references.pmid: 11833857
references.citation: Sleep. 2013 May 01;36(5):689-698G
references.pmid: 23633751
references.citation: Neuron. 2010 Oct 6;68(1):87-98
references.pmid: 20920793
references.citation: PLoS Biol. 2010 Oct 12;8(10):e1000503
references.pmid: 20967231
references.citation: Anesthesiology. 1985 Jun;62(6):738-44
references.pmid: 4003794
references.citation: Nature. 2008 Jan 31;451(7178):569-72
references.pmid: 18185515
references.citation: Genetics. 1998 Jul;149(3):1335-51
references.pmid: 9649524
references.citation: J Exp Zool. 1999 Jul 1;284(2):147-57
references.pmid: 10404644
references.citation: Curr Biol. 2001 Dec 11;11(24):1975-80
references.pmid: 11747825
references.citation: Sleep. 2013 Mar 01;36(3):385-95
references.pmid: 23449971
references.citation: PLoS Biol. 2008 Mar 25;6(3):e69
references.pmid: 18366255
references.citation: Dev Biol. 1985 Jan;107(1):128-33
references.pmid: 2578115
references.citation: PLoS Biol. 2008 Aug 26;6(8):e216
references.pmid: 18752355
references.citation: Physiol Genomics. 2007 Nov 14;31(3):441-57
references.pmid: 17698924
references.citation: Neuron. 2009 Jan 29;61(2):213-9
references.pmid: 19186164
references.citation: Am J Physiol. 1998 Aug;275(2):R509-14
references.pmid: 9688687