title: The VPS35 gene and Parkinson's disease.
abstract: Parkinson's disease (PD), the second most common age-related neurodegenerative disease, is characterized by loss of dopaminergic and nondopaminergic neurons, leading to a variety of motor and nonmotor symptoms. In addition to environmental factors, genetic predisposition and specific gene mutations have been shown to play an important role in the pathogenesis of this disorder. Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late-onset PD, has provided new clues to the pathogenesis of PD. Here we discuss the VPS35 gene, its protein function, and various pathways involved in Wnt/β-catenin signaling and in the role of DMT1 mediating the uptake of iron and iron translocation from endosomes to the cytoplasm. Further understanding of these mechanisms will undoubtedly provide new insights into the pathogenic mechanisms of PD and may lead to prevention and better treatment of the disorder.
authors.affiliation: Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha, China. hdeng008@yahoo.com
authors.forename: Hao
authors.initials: H
authors.lastname: Deng
authors.forename: Kai
authors.initials: K
authors.lastname: Gao
authors.forename: Joseph
authors.initials: J
authors.lastname: Jankovic
mesh_terms: D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics; D033921:Vesicular Transport Proteins / Q000235:genetics*
chemical_list: C110547:DMRT1 protein; D014157:Transcription Factors; C419573:VPS35 protein, human; D033921:Vesicular Transport Proteins