title: Troponin I, but not BNP, is associated with phosphorus, calcium and vitamin D in stable coronary artery disease.
abstract: BACKGROUND
  Elevated plasma cardiac troponin, elevated plasma phosphorus and decreased plasma vitamin D have been shown to be associated with negative outcomes.
  
  
  RESULTS
  Troponin I, calcium, phosphorus and 25-OH vitamin D were studied in a cohort of 60 patients with stable coronary heart disease and preserved left ventricular function. Using a cut-off value of 0.012 ng/mL for plasma troponin I, patients with higher values (18 patients), when compared to the other patients (n=42), had higher mean values for plasma phosphorus (3.42+0.45 mg/dL vs 3.17+0.45 mg/dL, p= 0.041) and calcium (5.08+0.23 mEq/L vs 4.92+0.18 mEq/L, p= 0.016) and lower values for 25-OH vitamin D (14.2+5.6 ng/mL vs 19.4+8.8 ng/mL, p= 0.032). Binary logistic regression analysis showed that troponin I > 0.012 ng/ml is associated with increased phosphorus, increased calcium and decreased 25-OH vitamin D concentrations. A similar analysis using BNP >100 pg/mL failed to show signifcant associations with phosphorus, calcium and 25-OH vitamin D concentrations.
  
  
  CONCLUSIONS
  In patients with stable coronary artery disease and preserved left ventricular function, those having cardiac troponin I > 0.012 ng/ml, but not those having BNP >100 pg/mL, had higher plasma phosphorus, higher plasma calcium and lower plasma 25-OH vitamin D concentrations than those having cardiac troponin I ≤ 0.012 ng/ml (or BNP ≤ 100 pg/mL).
authors.affiliation: Faculdade de Medicina da Universidade do Porto: Center for Research in Health Technologies and Information Systems (Cintesis), Porto. jplnunes@med.up.pt
authors.forename: José Pedro L
authors.initials: JP
authors.lastname: Nunes
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010758:Phosphorus / Q000097:blood*; D019210:Troponin I / Q000097:blood*; D014807:Vitamin D / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I; D020097:Natriuretic Peptide, Brain; D014807:Vitamin D; D010758:Phosphorus; D002118:Calcium