title: Oxidative stress and cardiovascular health: therapeutic potential of polyphenols.
abstract: Reactive oxygen species (ROS) are important in normal cellular function and physiology. However, oxidative stress resulting from an accumulation of ROS has a detrimental impact on cellular function, and ROS has been implicated in the pathogenesis of a number of diseases, including cardiovascular diseases. This review provides a summary of the impact of ROS on cardiovascular health and diseases, highlighting the therapeutic use of antioxidants. In addition, this review summarizes the health benefits of polyphenols, and the recent progress on understanding the cellular and physiological actions by which polyphenols may impart their beneficial properties on cardiovascular health.
authors.affiliation: Medical Sciences Division, Northern Ontario School of Medicine, Laurentian University, Sudbury, ON, Canada.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Khurana
authors.forename: Matthew
authors.initials: M
authors.lastname: Piche
authors.forename: Amanda
authors.initials: A
authors.lastname: Hollingsworth
authors.forename: Krishnan
authors.initials: K
authors.lastname: Venkataraman
authors.forename: T C
authors.initials: TC
authors.lastname: Tai
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism*; D002986:Clinical Trials as Topic / Q000379:methods; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D059808:Polyphenols / Q000494:pharmacology / Q000627:therapeutic use*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D059808:Polyphenols; D017382:Reactive Oxygen Species