title: [Functions of PALB2 and BRCA2 tumor suppressors in DNA double-strand break repair].
abstract: Cancer is now the leading cause of mortality in France. It has been clearly demonstrated that mutations in the genetic information is the initiating event of cancer. DNA damage such as DNA double-strand breaks leads to genomic instability and cancer development. Cells can repair DNA double-strand breaks through several mechanisms. Nevertheless, only homologous recombination repair is faithful and repairs DNA without creating mutations. Here, we review the roles of PALB2 and BRCA2 in homologous recombination and genome stability.
authors.affiliation: Genome stability laboratory, Laval university cancer research center, Hôtel-Dieu de Quebec research center (CHUQ), 9 McMahon, Québec, G1R 2J6, Canada.
authors.forename: Rémi
authors.initials: R
authors.lastname: Buisson
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Masson
mesh_terms: D024682:BRCA2 Protein / Q000502:physiology*; D053903:DNA Breaks, Double-Stranded; D000076164:Fanconi Anemia Complementation Group N Protein; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D009687:Nuclear Proteins / Q000502:physiology*; D059767:Recombinational DNA Repair / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology*
chemical_list: D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D000076164:Fanconi Anemia Complementation Group N Protein; D009687:Nuclear Proteins; C512790:PALB2 protein, human; D025521:Tumor Suppressor Proteins