title: Therapeutic potential of SIGIRR in systemic lupus erythematosus.
abstract: Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. Different from other typical IL-1R superfamily members, SIGIRR seems to exert negatively modulates in immune responses. Several previous studies demonstrated that SIGIRR influences chronic inflammatory or autoimmune diseases, such as intestinal inflammation, rheumatoid arthritis and psoriatic arthritis. Recent work has explored the role of SIGIRR in systemic lupus erythematosus (SLE), for example, the role of SIGIRR protects the mice from hydrocarbon oil-induced lupus has been reported. These results indicate that SIGIRR may represent a novel target for the treatment of SLE. In this review, we will discuss the SIGIRR and the therapeutic potential of modulating the pathway in SLE.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Feng
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: De-Guang
authors.initials: DG
authors.lastname: Wang
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000818:Animals; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D017472:Receptors, Interleukin-1 / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology / Q000502:physiology*
chemical_list: D017472:Receptors, Interleukin-1; C546891:SIGIRR protein, human
references.citation: Brain Behav Immun. 2010 Aug;24(6):985-95
references.pmid: 20394816
references.citation: Rinsho Byori. 2006 Jul;54(7):706-13
references.pmid: 16913661
references.citation: J Neurochem. 2008 Jun;105(5):1960-9
references.pmid: 18284608
references.citation: Immunity. 2007 Apr;26(4):461-75
references.pmid: 17398123
references.citation: Trends Neurosci. 2002 Mar;25(3):154-9
references.pmid: 11852148
references.citation: Nat Immunol. 2003 Sep;4(9):823-4
references.pmid: 12942080
references.citation: J Pathol. 2010 Apr;220(5):596-607
references.pmid: 20112371
references.citation: Cytokine. 1999 Jun;11(6):389-99
references.pmid: 10346978
references.citation: J Neurochem. 2005 Oct;95(2):324-30
references.pmid: 16086690
references.citation: J Intern Med. 2009 Jun;265(6):644-52
references.pmid: 19493058
references.citation: Bull NYU Hosp Jt Dis. 2007;65(3):194-9
references.pmid: 17922669
references.citation: Lupus. 2012 Oct;21(11):1166-71
references.pmid: 22634523
references.citation: J Immunol. 2006 Jul 1;177(1):548-56
references.pmid: 16785552
references.citation: Trends Immunol. 2009 Sep;30(9):439-46
references.pmid: 19699681
references.citation: Annu Rev Immunol. 2007;25:419-41
references.pmid: 17378763
references.citation: Cancer Res. 2007 Jul 1;67(13):6017-21
references.pmid: 17616656
references.citation: J Exp Med. 2008 Aug 4;205(8):1879-88
references.pmid: 18644972
references.citation: J Immunol. 2008 Mar 15;180(6):4022-31
references.pmid: 18322211
references.citation: Mol Med. 2005 Jan-Dec;11(1-12):21-9
references.pmid: 16622521
references.citation: Arthritis Res Ther. 2010;12(2):R53
references.pmid: 20334681
references.citation: Eur Cytokine Netw. 2003 Oct-Dec;14(4):211-8
references.pmid: 14715412
references.citation: Ann Rheum Dis. 2006 Dec;65(12):1585-9
references.pmid: 16439436
references.citation: Arthritis Rheum. 2009 Dec;60(12):3531-3
references.pmid: 19950267
references.citation: PLoS One. 2012;7(8):e44131
references.pmid: 22952899
references.citation: Mod Rheumatol. 2009;19(5):457-68
references.pmid: 19618249
references.citation: Immunity. 2010 Jan 29;32(1):54-66
references.pmid: 20060329
references.citation: J Immunol. 2009 Mar 1;182(5):2601-9
references.pmid: 19234154
references.citation: Arthritis Rheum. 2010 Aug;62(8):2249-61
references.pmid: 20506350