title: Mapping the spatio-temporal structure of motor cortical LFP and spiking activities during reach-to-grasp movements.
abstract: Grasping an object involves shaping the hand and fingers in relation to the object's physical properties. Following object contact, it also requires a fine adjustment of grasp forces for secure manipulation. Earlier studies suggest that the control of hand shaping and grasp force involve partially segregated motor cortical networks. However, it is still unclear how information originating from these networks is processed and integrated. We addressed this issue by analyzing massively parallel signals from population measures (local field potentials, LFPs) and single neuron spiking activities recorded simultaneously during a delayed reach-to-grasp task, by using a 100-electrode array chronically implanted in monkey motor cortex. Motor cortical LFPs exhibit a large multi-component movement-related potential (MRP) around movement onset. Here, we show that the peak amplitude of each MRP component and its latency with respect to movement onset vary along the cortical surface covered by the array. Using a comparative mapping approach, we suggest that the spatio-temporal structure of the MRP reflects the complex physical properties of the reach-to-grasp movement. In addition, we explored how the spatio-temporal structure of the MRP relates to two other measures of neuronal activity: the temporal profile of single neuron spiking activity at each electrode site and the somatosensory receptive field properties of single neuron activities. We observe that the spatial representations of LFP and spiking activities overlap extensively and relate to the spatial distribution of proximal and distal representations of the upper limb. Altogether, these data show that, in motor cortex, a precise spatio-temporal pattern of activation is involved for the control of reach-to-grasp movements and provide some new insight about the functional organization of motor cortex during reaching and object manipulation.
authors.affiliation: Institut de Neurosciences de la Timone, UMR 7289, Centre National de la Recherche Scientifique - Aix-Marseille Université Marseille, France ; Riken Brain Science Institute Wako-Shi, Japan.
authors.forename: Alexa
authors.initials: A
authors.lastname: Riehle
authors.forename: Sarah
authors.initials: S
authors.lastname: Wirtssohn
authors.forename: Sonja
authors.initials: S
authors.lastname: Grün
authors.forename: Thomas
authors.initials: T
authors.lastname: Brochier
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001931:Brain Mapping / Q000379:methods; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D008253:Macaca mulatta; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*
keywords: LFP; cortical map; high-density recordings; monkey motor cortex; spiking activity
references.citation: J Neurosci. 2011 Jun 15;31(24):8812-21
references.pmid: 21677165
references.citation: J Neurophysiol. 2000 Jan;83(1):528-36
references.pmid: 10634893
references.citation: Front Hum Neurosci. 2011 Apr 25;5:40
references.pmid: 21629859
references.citation: Exp Neurol. 2013 Jul;245:15-26
references.pmid: 23022918
references.citation: Trends Neurosci. 1995 Jul;18(7):314-20
references.pmid: 7571012
references.citation: J Neurophysiol. 2007 Jul;98(1):488-501
references.pmid: 17329624
references.citation: J Neurophysiol. 1999 Feb;81(2):825-34
references.pmid: 10036283
references.citation: Nature. 2008 Aug 14;454(7206):881-5
references.pmid: 18633351
references.citation: J Neurophysiol. 2004 Sep;92(3):1770-82
references.pmid: 15163676
references.citation: Exp Brain Res. 1972;14(3):257-73
references.pmid: 4626361
references.citation: J Neurophysiol. 2004 Nov;92(5):2968-84
references.pmid: 15163675
references.citation: Cereb Cortex. 2012 Sep;22(9):2148-59
references.pmid: 22021914
references.citation: Exp Brain Res. 1993;94(3):471-7
references.pmid: 8359261
references.citation: J Neurosci. 1999 Jun 1;19(11):4595-608
references.pmid: 10341257
references.citation: Cereb Cortex. 2011 Dec;21(12):2681-95
references.pmid: 21508303
references.citation: J Neurophysiol. 1978 Sep;41(5):1120-31
references.pmid: 100584
references.citation: Cereb Cortex. 2000 Jan;10(1):58-68
references.pmid: 10639396
references.citation: J Neurophysiol. 2001 Nov;86(5):2125-43
references.pmid: 11698506
references.citation: J Neurophysiol. 2012 Mar;107(5):1337-55
references.pmid: 22157115
references.citation: Nature. 1964 Jul 25;203:380-4
references.pmid: 14197376
references.citation: J Neurosci. 2001 Apr 15;21(8):2784-92
references.pmid: 11306630
references.citation: J Mot Behav. 1984 Sep;16(3):235-54
references.pmid: 15151851
references.citation: Front Neural Circuits. 2013 Mar 27;7:48
references.pmid: 23543888
references.citation: J Neurophysiol. 1995 May;73(5):2072-93
references.pmid: 7623099
references.citation: Exp Brain Res. 1972;14(3):243-56
references.pmid: 4626360
references.citation: J Neurophysiol. 1966 Nov;29(6):1011-27
references.pmid: 4961643
references.citation: Cereb Cortex. 2010 Jan;20(1):169-86
references.pmid: 19561063
references.citation: Exp Brain Res. 1999 Sep;128(1-2):31-40
references.pmid: 10473737
references.citation: J Physiol. 1981 Feb;311:497-519
references.pmid: 7264981
references.citation: J Mot Behav. 1986 Sep;18(3):245-60
references.pmid: 15138146
references.citation: Behav Brain Res. 2006 May 15;169(2):335-51
references.pmid: 16530860
references.citation: J Neurophysiol. 2007 May;97(5):3351-64
references.pmid: 17360824
references.citation: Exp Brain Res. 1981;42(3-4):435-41
references.pmid: 7238682
references.citation: Nat Neurosci. 2006 Dec;9(12):1549-57
references.pmid: 17115042
references.citation: Res Publ Assoc Res Nerv Ment Dis. 1952;30:238-64
references.pmid: 12983675
references.citation: J Neurophysiol. 2003 Mar;89(3):1503-18
references.pmid: 12626625
references.citation: Psychophysiology. 2012 Jan;49(1):17-30
references.pmid: 21895686
references.citation: J Neurosci. 2010 Mar 24;30(12):4440-8
references.pmid: 20335480
references.citation: Exp Brain Res. 2001 Sep;140(1):46-55
references.pmid: 11500797
references.citation: Fed Proc. 1986 Nov;45(12):2687-99
references.pmid: 3533637
references.citation: Science. 1993 Jul 23;261(5120):489-92
references.pmid: 8332915
references.citation: J Neurophysiol. 1992 Nov;68(5):1867-81
references.pmid: 1479450
references.citation: J Neurophysiol. 2010 Nov;104(5):2338-51
references.pmid: 20884766
references.citation: J Physiol. 1997 May 15;501 ( Pt 1):225-41
references.pmid: 9175005
references.citation: J Comp Neurol. 1993 Jul 8;333(2):199-209
references.pmid: 8393892
references.citation: Exp Brain Res. 1991;86(1):199-208
references.pmid: 1756790
references.citation: Eur J Neurosci. 2007 Feb;25(4):1245-52
references.pmid: 17331220
references.citation: J Neurosci. 2010 Jul 21;30(29):9659-69
references.pmid: 20660249
references.citation: J Neurophysiol. 1964 Mar;27:152-71
references.pmid: 14129768
references.citation: Physiol Rev. 1985 Jan;65(1):37-100
references.pmid: 3880898