title: A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion.
abstract: The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M : L is 1 : 1 (M = Co(II) or Fe(III)) at pH 5.5-7.0, with free L being more active at acidic pH than when bound to Zn(II), Cu(II) or Ni(II) at neutral pH.
authors.affiliation: Departament de Química Inorgànica, Facultat de Farmàcia, Universitat de València, 46100-Burjassot, Valencia, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Hernández-Gil
authors.forename: Sacramento
authors.initials: S
authors.lastname: Ferrer
authors.forename: Elena
authors.initials: E
authors.lastname: Salvador
authors.forename: Javier
authors.initials: J
authors.lastname: Calvo
authors.forename: Enrique
authors.initials: E
authors.lastname: Garcia-España
authors.forename: Juan C
authors.initials: JC
authors.lastname: Mareque-Rivas
mesh_terms: D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D053837:DNA Cleavage; D008024:Ligands; D010957:Plasmids; D011725:Pyridines / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry*
chemical_list: C514153:1,3-bis(bis(pyridin-2-ylmethyl)amino)propan-2-ol; D056831:Coordination Complexes; D008024:Ligands; D011725:Pyridines; D028561:Transition Elements; D004247:DNA