title: Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma.
abstract: This study evaluates the role of scavenger receptor class A member 3 (SCARA3) in multiple myeloma (MM). SCARA3 expression was induced upon treatment with oxidative stressors (ionizing radiation and chemotherapeutic drugs). An epigenetic inactivation of SCARA3 was noted in MM.1S myeloma cells. Myeloma cell killing by dexamethasone and bortezomib was inhibited by up-regulation of SCARA3 while SCARA3 knockdown sensitized myeloma cells to the drugs. Clinical samples showed an inverse correlation between SCARA3 gene expression, myeloma progression, and favorable clinical prognosis. In MM, SCARA3 protects against oxidative stress-induced cell killing and can serve as predictor of MM progression and therapeutic response.
authors.affiliation: Free Radical and Radiation Biology Program, Department of Radiation Oncology, USA.
authors.forename: Charles O
authors.initials: CO
authors.lastname: Brown
authors.forename: Jeanine
authors.initials: J
authors.lastname: Schibler
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Fitzgerald
authors.forename: Neeraj
authors.initials: N
authors.lastname: Singh
authors.forename: Kelley
authors.initials: K
authors.lastname: Salem
authors.forename: Fenghuang
authors.initials: F
authors.lastname: Zhan
authors.forename: Apollina
authors.initials: A
authors.lastname: Goel
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001374:Azacitidine / Q000031:analogs & derivatives / Q000494:pharmacology; D001897:Boronic Acids / Q000494:pharmacology; D000069286:Bortezomib; D002460:Cell Line; D045744:Cell Line, Tumor; D000077209:Decitabine; D003907:Dexamethasone / Q000494:pharmacology; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000528:radiation effects; D055785:Gene Knockdown Techniques; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000494:pharmacology; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D020411:Oligonucleotide Array Sequence Analysis; D016877:Oxidants / Q000494:pharmacology; D011379:Prognosis; D011719:Pyrazines / Q000494:pharmacology; D011839:Radiation, Ionizing; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051117:Scavenger Receptors, Class A / Q000235:genetics* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D004791:Enzyme Inhibitors; D006360:Heat-Shock Proteins; D006877:Hydroxamic Acids; D016877:Oxidants; D011719:Pyrazines; C112525:SCARA3 protein, human; D051117:Scavenger Receptors, Class A; C012589:trichostatin A; D000069286:Bortezomib; D000077209:Decitabine; D003907:Dexamethasone; D006861:Hydrogen Peroxide; D001374:Azacitidine
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