title: Coagulopathies in the PICU: DIC and liver disease.
abstract: Bleeding in patients in pediatric intensive care units is associated with an increased risk of mortality. Fortunately, most patients with an abnormal coagulation profile do not bleed because this is generally secondary to liver disease or dietary-induced vitamin K deficiency. When the laboratory markers of coagulopathy are the result of disseminated intravascular coagulation, bleeding is common and the risk of mortality extreme. Although interventions directed toward correcting the abnormal coagulation test results are generally initiated, they are also generally either not warranted or not fully successful.
authors.affiliation: Pediatric Hematology/Oncology, Stony Brook Long Island Children's Hospital, Stony Brook University School of Medicine, 100 Nicolls Road, Stony Brook, NY 11794, USA. rparker@notes.cc.sunysb.edu
authors.forename: Robert I
authors.initials: RI
authors.lastname: Parker
mesh_terms: D015415:Biomarkers / Q000097:blood; D001778:Blood Coagulation Disorders / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D001803:Blood Transfusion; D002648:Child; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D020141:Hemostatic Disorders / Q000188:drug therapy / Q000209:etiology; D048550:Hepatic Insufficiency / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D015278:Intensive Care Units, Pediatric; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D001779:Blood Coagulation Factors