title: Toxic epidermal necrolysis induced by lansoprazole.
abstract: Toxic epidermal necrolysis is a rare, severe cutaneous reaction, mostly caused by drugs. It affects the skin and mucous membranes, with involvement of more than 30% of body surface. We describe the case of a young woman, previously healthy, who developed skin detachment of more than 90% of the body surface 15 days after being administered lansoprazole for peptic disease. The treatment consisted in discontinuation of the drug involved and early administration of intravenous human immunoglobulin, which led to a satisfactory outcome of the case, substantiating the impact of early diagnosis and treatment on the morbidity and mortality of these patients.
authors.affiliation: Dermatology at the Teaching Hospital, State University of Rio de Janeiro (Hospital Universitário Pedro Ernesto – Universidade do Estado do Rio de Janeiro - HUPE-UERJ), Rio de Janeiro, (RJ), Brazil. tsfracaroli@yahoo.com.br
authors.forename: Tainá Scalfoni
authors.initials: TS
authors.lastname: Fracaroli
authors.forename: Ludmilla Queirós
authors.initials: LQ
authors.lastname: Miranda
authors.forename: João Luz
authors.initials: JL
authors.lastname: Sodré
authors.forename: Mário
authors.initials: M
authors.lastname: Chaves
authors.forename: Alexandre
authors.initials: A
authors.lastname: Gripp
mesh_terms: D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage; D007155:Immunologic Factors / Q000008:administration & dosage; D007275:Injections, Intravenous; D064747:Lansoprazole / Q000009:adverse effects*; D054328:Proton Pump Inhibitors / Q000009:adverse effects; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology*; D055815:Young Adult
chemical_list: D000897:Anti-Ulcer Agents; D007136:Immunoglobulins; D007155:Immunologic Factors; D054328:Proton Pump Inhibitors; D064747:Lansoprazole
references.citation: J Am Acad Dermatol. 2007 Feb;56(2):181-200
references.pmid: 17224365
references.citation: Clin Exp Dermatol. 2010 Dec;35(8):853-62
references.pmid: 20456393
references.citation: Br J Dermatol. 2005 Aug;153(2):241-53
references.pmid: 16086734
references.citation: Australas J Dermatol. 2009 Aug;50(3):207-10
references.pmid: 19659985
references.citation: J Am Acad Dermatol. 2008 Jan;58(1):33-40
references.pmid: 17919775
references.citation: Arch Dermatol. 1993 Jan;129(1):92-6
references.pmid: 8420497
references.citation: Int J Immunopathol Pharmacol. 2007 Jul-Sep;20(3):557-66
references.pmid: 17880768
references.citation: Arch Dermatol. 1990 Jan;126(1):37-42
references.pmid: 2134982
references.citation: Clin Exp Dermatol. 2004 Nov;29(6):612-3
references.pmid: 15550134