title: The role of Nrf2 in the attenuation of cardiovascular disease.
abstract: Oxidative stress is a component of many human diseases, including cardiovascular diseases (CVD). Exercise and various phytochemicals activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses, and attenuate CVD. This review highlights Nrf2 regulation by exercise and phytochemicals and the role of Nrf2 as a therapeutic target in CVD.
authors.affiliation: Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA. nellie.reuland@colostate.edu
authors.forename: Danielle J
authors.initials: DJ
authors.lastname: Reuland
authors.forename: Joe M
authors.initials: JM
authors.lastname: McCord
authors.forename: Karyn L
authors.initials: KL
authors.lastname: Hamilton
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D015444:Exercise / Q000502:physiology*; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D018384:Oxidative Stress; D064209:Phytochemicals / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D064209:Phytochemicals; C509374:Protandim