title: Response of serum minerals (calcium, phosphate, and magnesium) and endocrine glands (calcitonin cells and parathyroid gland) of Wistar rat after chlorpyrifos administration.
abstract: Wistar rats (male) were daily administered chlorpyrifos at a dose of 5 mg/kg b wt. and 10 mg/kg b wt. and sacrificed on 1st, 2nd, 4th, 6th, and 8th week. In chlorpyrifos exposed rats hypocalcemia, hypophosphatemia and hypomagnesemia were recorded. At later intervals an increased levels of serum calcium and phosphate were observed. The parathyroid glands and calcitonin cells exhibited increased activity which is evident by increased nuclear volume of these cells.
authors.affiliation: Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, India.
authors.forename: Sarojni
authors.initials: S
authors.lastname: Tripathi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Suzuki
authors.forename: Ajai Kumar
authors.initials: AK
authors.lastname: Srivastav
mesh_terms: D000818:Animals; D004390:Chlorpyrifos / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D004195:Disease Models, Animal; D008297:Male; D008903:Minerals / Q000097:blood*; D062025:Organophosphate Poisoning / Q000473:pathology* / Q000503:physiopathology*; D010280:Parathyroid Glands / Q000187:drug effects / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D044967:Serum / Q000737:chemistry
chemical_list: D002800:Cholinesterase Inhibitors; D008903:Minerals; D004390:Chlorpyrifos