title: Five-year follow-up of 263 cases of functional bowel disorder.
abstract: OBJECTIVE
  To determine the mortality associated with functional bowel disorders (FBDs) and their possible relationship with organic bowel disease.
  
  
  METHODS
  Patients who satisfied the Rome III criteria for FBD (retrospective diagnosis) were followed up by telephone interview and/or outpatient review at 5 years after their first attendance. The patients were divided into the following groups: irritable bowel syndrome, functional abdominal bloating, functional constipation, functional diarrhea and unspecified FBD. The survival of the FBD patients overall and of those with each FBD were compared with data obtained from the Guangzhou population in 2005. The incidences of colonic cancer overall and for each FBD were compared with data from the Chinese population obtained from 56 cancer registries in 19 provinces of the country in 2008.
  
  
  RESULTS
  Two hundred and sixty-three patients were followed-up. Five patients died, which was not significantly different from the expected survival rate. No differences in mortality among the FBDs were found. There were nine cases of organic bowel disease: three colonic cancers and six colonic polyps. The incidence of colonic cancer in FBD patients was higher than that in the general Chinese population (0.23% vs 0.03%, P < 0.05). There were significant differences in the incidence of colonic cancer among the FBDs (0/134, 0/24, 2/29, 1/66, 0/10, respectively, P < 0.05); functional constipation was the most common. The incidence of colonic polyps was similar among the FBDs. The baseline age of patients who died was greater than that of those who survived (66.60 ± 6.84 years vs 45.14 ± 10.34 years, P < 0.05). The baseline age of patients who had colonic cancer or polyps during follow-up was greater than that of those without colonic cancer or polyps (60.33 ± 1.53 years vs 45.38 ± 10.62 years; 54.50 ± 6.47 years vs 45.34 ± 10.68 years, P < 0.05).
  
  
  CONCLUSIONS
  FBDs do not increase the risk of death. The incidence of colonic cancer in patients with FBDs may be increased, especially in those with functional constipation and in the elderly.
authors.affiliation: Department of Gastroenterology, Nanjing Jiangbei People's Hospital, Medical School, Southeast University, 552 Geguan Road, Nanjing 210048, Jiangsu Province, China.
authors.forename: Yu-Rong
authors.initials: YR
authors.lastname: Tang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Yin
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Ge
authors.forename: Guo-Pin
authors.initials: GP
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003110:Colonic Neoplasms / Q000453:epidemiology; D003111:Colonic Polyps / Q000453:epidemiology; D003248:Constipation / Q000453:epidemiology; D003967:Diarrhea / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007410:Intestinal Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D043183:Irritable Bowel Syndrome / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors
keywords: Colonic cancer; Colonic polyps; Follow-up; Functional bowel disorders; Mortality
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