title: Drug-induced cholestasis.
abstract: Cholestasis caused by drugs is an important differential diagnosis in patients presenting with a biochemical cholestatic pattern. The extent of serologic tests and radiological imaging depends on the clinical context. The underlying condition of the patient and detailed information on drug use, results of rechallenge, and the documented hepatotoxicity of the drug are important to establish a diagnosis of drug-induced liver injury (DILI). Most cases of cholestatic DILI are mild, but in rare cases, ductopenia and cholestatic cirrhosis can develop. Approximately 10% of patients with cholestatic jaundice caused by drugs develop liver failure.
authors.affiliation: Division of Gastroenterology and Hepatology, The National University Hospital of Iceland, Hringbraut 101, Reykjavik, Iceland. einarsb@landspitali.is
authors.forename: Einar S
authors.initials: ES
authors.lastname: Bjornsson
authors.forename: Jon Gunnlaugur
authors.initials: JG
authors.lastname: Jonasson
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D044966:Anti-Retroviral Agents / Q000009:adverse effects; D000935:Antifungal Agents / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000175:diagnosis*; D002779:Cholestasis / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D002908:Chronic Disease; D006801:Humans; D011379:Prognosis; D011619:Psychotropic Drugs / Q000009:adverse effects; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D044966:Anti-Retroviral Agents; D000935:Antifungal Agents; D011619:Psychotropic Drugs; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase