title: Clinicopathological features and localization of gastric cancers and their effects on survival in Turkey.
abstract: BACKGROUND
  This study was designed to examine changing trends in localization of gastric cancer in Turkey in recent years.
  
  
  METHODS
  A total of 796 adult patients with newly diagnosed, histologically proven adenocarcinomas, treated and followed up at our oncology center between 2000-2011, were examined retrospectively. In all cases tumor localization were identified and recorded with clinicopathological features.
  
  
  RESULTS
  The median age was 58 with a range between 22-90 for the 552 men and 244 women. Median follow up was 12 months (1-276) and median overall survival was also 12 months (11.5-12.4). There was a trend for a change in tumor localization from distal to proximal. Survival of patients was low with advanced T and N stage tumours. Positive surgical margins, lymphovascular invasion, perineural invasion, cardioesophageal localization were predisposition factors for metastatic disease in gastric cancer. There was no relation between age or sex and histopathological type of gastric cancer.
  
  
  CONCLUSIONS
  There is a trend in our country for a change in gastric tumour localization from distal to proximal, with clear significance for treatment choices.
authors.affiliation: Sisli Education and Research Hospital, Istanbul, Turkey. drfatih74@yahoo.com
authors.forename: Fatih
authors.initials: F
authors.lastname: Selcukbiricik
authors.forename: Deniz
authors.initials: D
authors.lastname: Tural
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bilici
authors.forename: Esengul Kocak
authors.initials: EK
authors.lastname: Uzel
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozguroglu
authors.forename: Fuat
authors.initials: F
authors.lastname: Demirelli
authors.forename: Evin
authors.initials: E
authors.lastname: Buyukunal
authors.forename: Suheyla
authors.initials: S
authors.lastname: Serdengecti
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002299:Cardia / Q000473:pathology; D004943:Esophagogastric Junction / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000473:pathology; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*; D016019:Survival Analysis; D014421:Turkey; D055815:Young Adult