title: Genetic variations in the serotoninergic system contribute to body-mass index in Chinese adolescents.
abstract: OBJECTIVE
  Obesity has become a worldwide health problem in the past decades. Human and animal studies have implicated serotonin in appetite regulation, and behavior genetic studies have shown that body mass index (BMI) has a strong genetic component. However, the roles of genes related to the serotoninergic (5-hydroxytryptamine,5-HT) system in obesity/BMI are not well understood, especially in Chinese subjects.
  
  
  METHODS
  With a sample of 478 healthy Chinese volunteers, this study investigated the relation between BMI and genetic variations of the serotoninergic system as characterized by 136 representative polymorphisms. We used a system-level approach to identify SNPs associated with BMI, then estimated their overall contribution to BMI by multiple regression and verified it by permutation.
  
  
  RESULTS
  We identified 12 SNPs that made statistically significant contributions to BMI. After controlling for gender and age, four of these SNPs accounted for 7.7% additional variance of BMI. Permutation analysis showed that the probability of obtaining these findings by chance was low (p = 0.015, permuted for 1000 times).
  
  
  CONCLUSIONS
  These results showed that genetic variations in the serotoninergic system made a moderate contribution to individual differences in BMI among a healthy Chinese sample, suggesting that a similar approach can be used to study obesity.
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Chen
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Chuansheng
authors.initials: C
authors.lastname: Chen
authors.forename: Robert
authors.initials: R
authors.lastname: Moyzis
authors.forename: Qinghua
authors.initials: Q
authors.lastname: He
authors.forename: Xuemei
authors.initials: X
authors.lastname: Lei
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Yunxin
authors.initials: Y
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Daiming
authors.initials: D
authors.lastname: Xiu
authors.forename: Bi
authors.initials: B
authors.lastname: Zhu
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D002681:China; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011985:Receptors, Serotonin / Q000235:genetics; D012701:Serotonin / Q000378:metabolism; D050493:Vesicular Monoamine Transport Proteins / Q000235:genetics; D055815:Young Adult
chemical_list: D011985:Receptors, Serotonin; C493449:SLC18A1 protein, human; D050493:Vesicular Monoamine Transport Proteins; D012701:Serotonin
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