title: Asymptomatic brain lesions on cranial magnetic resonance imaging in inflammatory bowel disease.
abstract: OBJECTIVE
  This study aimed to examine the frequency and type of asymptomatic neurological involvement in inflammatory bowel disease (IBD) using cranial magnetic resonance imaging (MRI).
  
  
  METHODS
  Fifty-one IBD patients with no known neurological diseases or symptoms and 30 controls with unspecified headaches without neurological origins were included. Patients and controls underwent cranial MRI assessments for white matter lesions, sinusitis, otitis-mastoiditis, and other brain parenchymal findings.
  
  
  RESULTS
  The frequencies of white matter lesions, other brainstem parenchymal lesions, and otitis-mastoiditis were similar in IBD patients and controls (p>0.05), whereas sinusitis was significantly more frequent in IBD patients (56.9% vs 33.3%, p=0.041). However, among those subjects with white matter lesions, the number of such lesions was significantly higher in IBD patients compared to controls (12.75±9.78 vs 3.20±2.90, p<0.05). The incidence of examined pathologies did not differ significantly with disease activity (p>0.05 for all).
  
  
  CONCLUSIONS
  The incidence of white matter lesions seemed to be similar in IBD patients and normal healthy individuals, and the lesions detected did not pose any clinical significance. However, long-term clinical follow-up of the lesions is warranted.
authors.affiliation: Department of Gastroenterology, Dr. Lutfi Kirdar Kartal Research and Training Hospital, Istanbul, Turkey.
authors.forename: Can
authors.initials: C
authors.lastname: Dolapcioglu
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Guleryuzlu
authors.forename: Oya
authors.initials: O
authors.lastname: Uygur-Bayramicli
authors.forename: Emel
authors.initials: E
authors.lastname: Ahishali
authors.forename: Resat
authors.initials: R
authors.lastname: Dabak
keywords: Asymptomatic brain lesion; Inflammatory bowel disease; Magnetic resonance imaging; White matter lesions
references.citation: J Otolaryngol. 1985 Dec;14(6):399-400
references.pmid: 4078964
references.citation: Arthritis Rheum. 1991 Apr;34(4):432-41
references.pmid: 1901492
references.citation: Eur J Neurol. 2011 Jan;18(1):138-43
references.pmid: 20500801
references.citation: Cancer. 1991 Apr 1;67(7):2015-9
references.pmid: 2004319
references.citation: Neurologist. 2004 May;10(3):165-8
references.pmid: 15140276
references.citation: Inflamm Bowel Dis. 2010 Aug;16(8):1387-92
references.pmid: 20014016
references.citation: Br Med J. 1955 Oct 29;2(4947):1041-8
references.pmid: 13260656
references.citation: Lancet. 1998 May 23;351(9115):1558
references.pmid: 10326545
references.citation: Lancet. 1995 Jul 15;346(8968):190-1
references.pmid: 7603262
references.citation: Neuroradiology. 1993;35(2):142-4
references.pmid: 8433790
references.citation: Gastroenterology. 1976 Mar;70(3):439-44
references.pmid: 1248701
references.citation: Neurology. 1995 Mar;45(3 Pt 1):416-21
references.pmid: 7898687
references.citation: Clin Neurol Neurosurg. 2004 Mar;106(2):110-3
references.pmid: 15003300
references.citation: Ear Nose Throat J. 2001 Feb;80(2):97-100
references.pmid: 11233351
references.citation: HNO. 1993 Jan;41(1):33-6
references.pmid: 8449786
references.citation: Inflamm Bowel Dis. 2009 Apr;15(4):576-80
references.pmid: 19023898
references.citation: Lancet. 1995 Apr 8;345(8954):897-8
references.pmid: 7707814
references.citation: J Crohns Colitis. 2010 Jun;4(2):115-24
references.pmid: 21122494
references.citation: Eur J Neurol. 2007 May;14(5):483-93
references.pmid: 17437605
references.citation: World J Gastroenterol. 2006 Aug 14;12(30):4819-31
references.pmid: 16937463
references.citation: Otolaryngol Head Neck Surg. 1995 Dec;113(6):813-5
references.pmid: 7501401
references.citation: N Engl J Med. 2007 Nov 1;357(18):1821-8
references.pmid: 17978290
references.citation: N Engl J Med. 1997 Nov 20;337(21):1512-23
references.pmid: 9366584