title: Effect of metformin on selected parameters of hemostasis in fenofibrate-treated patients with impaired glucose tolerance.
abstract: BACKGROUND
  No previous study has assessed whether the addition of metformin potentiates fibrate action on hemostasis in prediabetic subjects.
  
  
  METHODS
  Our study included 41 fenofibrate-treated patients with impaired glucose tolerance allocated to either metformin (3 g daily) or placebo.
  
  
  RESULTS
  Twelve-week treatment with fenofibrate and metformin reduced plasma levels of fibrinogen and PAI-1 and tended to change the other hemostatic markers measured, as well as improved insulin sensitivity.
  
  
  CONCLUSIONS
  Our results show that high-dose metformin exhibits beneficial effects on coagulation and fibrinolysis in isolated IGT patients treated with a fibrate.
authors.affiliation: Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, PL 40-752 Katowice, Poland. r.krysiak@interia.pl
authors.forename: Robert
authors.initials: R
authors.lastname: Krysiak
authors.forename: Anna
authors.initials: A
authors.lastname: Gdula-Dymek
authors.forename: Bogusław
authors.initials: B
authors.lastname: Okopień
mesh_terms: D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D011345:Fenofibrate / Q000008:administration & dosage / Q000494:pharmacology*; D005340:Fibrinogen / Q000378:metabolism; D018149:Glucose Intolerance / Q000188:drug therapy; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology; D007333:Insulin Resistance; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D011236:Prediabetic State / Q000188:drug therapy*; D016037:Single-Blind Method
chemical_list: D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen; D008687:Metformin; D011345:Fenofibrate