title: Is decompressive craniectomy a risk factor for ventriculomegaly?
abstract: OBJECTIVE
  Decompressive craniectomy (DC) is an established therapeutic option following severe traumatic brain injury (TBI). However, several delayed complications of DC have been reported, including ventriculomegaly, which can lead to poor patient outcomes. Nevertheless, ventriculomegaly can occur after TBI even without DC. The aim of the present study was to investigate the influence of DC on ventriculomegaly.
  
  
  METHODS
  Adult male Sprague-Dawley rats (300-400 g) were subjected to lateral fluid percussion injury using a fluid percussion device. Rats were randomly divided into four groups: sham, craniectomized without trauma (D group), traumatized without DC (FPI group), and craniectomized immediately after trauma (FPI + D group). On day 28 of recovery, ventricular volumes were measured by image analysis.
  
  
  RESULTS
  There was no significant difference in ventricular size between the sham group and the D group animals or between the FPI group and the FPI + D group animals.
  
  
  CONCLUSIONS
  These data suggest that DC may not be a risk factor for ventriculomegaly after TBI.
authors.affiliation: Department of Neurosurgery, National Defense Medical College, Tokorozawa, Japan. s.takeuchi@room.ocn.ne.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Nagatani
authors.forename: Kojiro
authors.initials: K
authors.lastname: Wada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nawashiro
authors.forename: Naoki
authors.initials: N
authors.lastname: Otani
authors.forename: Hideo
authors.initials: H
authors.lastname: Osada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Takamoto
authors.initials: T
authors.lastname: Suzuki
authors.forename: Katsuji
authors.initials: K
authors.lastname: Shima
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000209:etiology / Q000601:surgery*; D056424:Decompressive Craniectomy / Q000009:adverse effects*; D004195:Disease Models, Animal; D006849:Hydrocephalus / Q000209:etiology*; D008297:Male; D010474:Percussion / Q000009:adverse effects; D011183:Postoperative Complications / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors; D018709:Statistics, Nonparametric