title: Cohort profile: The Gubbio Population Study.
abstract: The Gubbio Study is a prospective epidemiological study on the population residing in the city of Gubbio, Italy. Original objectives of the study were the control of hypertension and the role of cellular electrolyte handling in hypertension. Other objectives were added during the 30-year activity of the study. The original target cohort consists of individuals aged ≥5 years residing within the medieval walls of the city. To complete family genealogies, individuals residing outside the city were also included. Three active screenings (exams) were conducted. A total of 5376 individuals (response rate 92%) participated in Exam 1 which was performed in 1983-86. Follow-up exams were completed between 1989-92 and 2001-2007. Data categories included demographics, personal and family medical history, lifestyle habits, education, type of work, anthropometry, blood pressure, pulse rate, blood biochemistry, urine biochemistry and special investigations on cellular electrolyte handling. Electrocardiogram, echocardiogram, 24-h ambulatory blood pressure and uroflowmetry were performed in selected subgroups defined by age and/or sex. Data about hospitalizations, mortality and causes of death were collected starting from completion of Exam 1. The study shared the data with other studies.
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Italy, Centre of Preventive Medicine, Gubbio, Italy, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy, Association for Cardiac Research, Rome, Italy and Istituto Auxologico Italiano, University of Milan, Milan, Italy mcirillo@unisa.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Cirillo
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Italy, Centre of Preventive Medicine, Gubbio, Italy, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy, Association for Cardiac Research, Rome, Italy and Istituto Auxologico Italiano, University of Milan, Milan, Italy.
authors.forename: Oscar
authors.initials: O
authors.lastname: Terradura-Vagnarelli
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Italy, Centre of Preventive Medicine, Gubbio, Italy, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy, Association for Cardiac Research, Rome, Italy and Istituto Auxologico Italiano, University of Milan, Milan, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Mancini
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Italy, Centre of Preventive Medicine, Gubbio, Italy, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy, Association for Cardiac Research, Rome, Italy and Istituto Auxologico Italiano, University of Milan, Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Menotti
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Italy, Centre of Preventive Medicine, Gubbio, Italy, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy, Association for Cardiac Research, Rome, Italy and Istituto Auxologico Italiano, University of Milan, Milan, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Zanchetti
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Italy, Centre of Preventive Medicine, Gubbio, Italy, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy, Association for Cardiac Research, Rome, Italy and Istituto Auxologico Italiano, University of Milan, Milan, Italy.
authors.forename: Martino
authors.initials: M
authors.lastname: Laurenzi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D001837:Body Weights and Measures; D002648:Child; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D004573:Electrolytes; D005260:Female; D005826:Genetics, Medical; D015438:Health Behavior; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology* / Q000628:therapy; D007558:Italy / Q000453:epidemiology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000453:epidemiology; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D004573:Electrolytes
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