title: The aggregate effects of multiple comorbid risk factors on cognition among HIV-infected individuals.
abstract: This study developed and then cross-validated a novel weighting algorithm based on multiple comorbid risk factors (stimulant use, vascular disease, hepatitis C, HIV disease severity, cognitive reserve) to predict cognitive functioning among 366 HIV+ adults. The resultant "risk severity score" was used to differentially weight, as a function of age, the impact and magnitude of multiple risk factors on cognition. Among older adults (≥50 years) the risk severity index was differentially predictive of learning/memory and verbal fluency, whereas among younger adults it was linked to working memory and executive function. Cognitive reserve was found to be the most robust predictor of neurocognition.
authors.affiliation: Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA. smpatel@mednet.ucla.edu
authors.forename: Sapna M
authors.initials: SM
authors.lastname: Patel
authors.forename: April D
authors.initials: AD
authors.lastname: Thames
authors.forename: Natalie
authors.initials: N
authors.lastname: Arbid
authors.forename: Stella E
authors.initials: SE
authors.lastname: Panos
authors.forename: Steven
authors.initials: S
authors.lastname: Castellon
authors.forename: Charles H
authors.initials: CH
authors.lastname: Hinkin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000375:Aging / Q000473:pathology; D000465:Algorithms; D015415:Biomarkers; D003072:Cognition Disorders / Q000453:epidemiology* / Q000209:etiology; D015897:Comorbidity; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012307:Risk Factors; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000150:complications / Q000453:epidemiology; D014652:Vascular Diseases / Q000150:complications / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015415:Biomarkers
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