title: QD-filled micelles which combine SPECT and optical imaging with light-induced activation of a platinum(IV) prodrug for anticancer applications.
abstract: The fac-[(99m)Tc(OH2)3(CO)3](+) complex reacts with QD-filled micelles to create a bimodal SPECT-optical imaging probe which upon visible light irradiation generates cisplatin from an inert Pt(IV) prodrug.
authors.affiliation: School of Chemistry, University of Edinburgh, Edinburgh, UK.
authors.forename: Carmen R
authors.initials: CR
authors.lastname: Maldonado
authors.forename: Nina
authors.initials: N
authors.lastname: Gómez-Blanco
authors.forename: Maite
authors.initials: M
authors.lastname: Jauregui-Osoro
authors.forename: Valerie G
authors.initials: VG
authors.lastname: Brunton
authors.forename: Luis
authors.initials: L
authors.lastname: Yate
authors.forename: Juan C
authors.initials: JC
authors.lastname: Mareque-Rivas
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D006801:Humans; D008027:Light; D049449:Luminescence; D008297:Male; D008823:Micelles; D061848:Optical Imaging / Q000379:methods*; D011355:Prodrugs / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000188:drug therapy; D045663:Quantum Dots; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D011355:Prodrugs; D002945:Cisplatin