title: Intervention strategies for emerging viruses: use of antivirals.
abstract: Today, small molecule antiviral drugs are available for the treatment of infections with herpesviruses, HIV, HBV and HCV as well as with influenza viruses. Ribavirin, a broad-spectrum (but aspecific) antiviral, has been approved for the treatment of infections with respiratory syncytial virus, HCV and Lassa virus. Yet, for many other viruses that cause life-threatening infections [most of which are considered emerging and/or neglected] there are no drugs available. Ideally, potent and broad-spectrum (i.e., pan-genus or pan-family virus activity) antiviral drugs should be developed whereby one drug could be used for the treatment of a number of such viral infections. We here review recent evolutions in the search for inhibitors of emerging and neglected RNA viruses.
authors.affiliation: Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Debing
authors.forename: Dirk
authors.initials: D
authors.lastname: Jochmans
authors.forename: Johan
authors.initials: J
authors.lastname: Neyts
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification* / Q000627:therapeutic use*; D021821:Communicable Diseases, Emerging / Q000188:drug therapy* / Q000821:virology; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D006801:Humans; D014777:Virus Diseases / Q000188:drug therapy* / Q000821:virology
chemical_list: D000998:Antiviral Agents
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