title: Studies toward the biomimetic total synthesis of (-)-PF-1018.
abstract: Pericyclic reaction cascades are unparalleled in their ability to quickly generate complex structures with excellent stereocontrol. Herein, the use of a biomimetic Stille/8π electrocyclization/Diels-Alder cascade to successfully assemble the core structure of (-)-PF-1018 is reported.
authors.affiliation: Fakultät für Chemie und Pharmazie, Ludwig-Maximilians-Universität München, and Munich Center for Integrated Protein Science, Butenandtstrasse 5-13, 81377 München, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Webster
authors.forename: Boris
authors.initials: B
authors.lastname: Gaspar
authors.forename: Peter
authors.initials: P
authors.lastname: Mayer
authors.forename: Dirk
authors.initials: D
authors.lastname: Trauner
mesh_terms: D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011763:Pyrrolizidine Alkaloids; C088533:PF 1018