title: Eosinophil-derived neurotoxin levels at 3 months post-respiratory syncytial virus bronchiolitis are a predictive biomarker of recurrent wheezing.
abstract: OBJECTIVE
  To determine whether eosinophil-derived neurotoxin (EDN) is a predictive marker of recurrent wheezing episodes in post-respiratory syncytial virus (RSV) bronchiolitis.
  
  
  METHODS
  EDN levels and recurrent wheezing episodes were serially measured in 200 infants hospitalized with RSV bronchiolitis.
  
  
  RESULTS
  Serum EDN levels at 3 months correlated significantly with total wheezing episodes at 12 months in the RSV-PLC (n  = 71; r = 0.720, p < 0.0001) and RSV-MONT groups (n = 79; r = 0.531, p < 0.001). Positive predictive value of 3-mo EDN level for total wheezing episodes was 57%; negative predictive value, 76%; sensitivity, 72%; specificity, 62%.
  
  
  CONCLUSIONS
  EDN levels have predictive value for the development of recurrent wheezing post-RSV bronchiolitis.
authors.affiliation: Asthma and Allergy Center, Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
authors.forename: Chang-Keun
authors.initials: CK
authors.lastname: Kim
authors.forename: Jeong Koo
authors.initials: JK
authors.lastname: Seo
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Ban
authors.forename: Takao
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Kim
authors.forename: Zak
authors.initials: Z
authors.lastname: Callaway
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D001990:Bronchiolitis, Viral / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology / Q000821:virology; D047208:Eosinophil-Derived Neurotoxin / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012008:Recurrence; D012135:Respiratory Sounds / Q000175:diagnosis*; D018357:Respiratory Syncytial Virus Infections / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology / Q000821:virology; D012136:Respiratory Syncytial Viruses
chemical_list: D015415:Biomarkers; D047208:Eosinophil-Derived Neurotoxin