title: Treatments in context: transcranial direct current brain stimulation as a potential treatment in pediatric psychosis.
abstract: Childhood-onset schizophrenia is a chronic, severe form of schizophrenia, and is typically treatment resistant. Even after optimized pharmacotherapy, a majority (over 70%) of these pediatric patients present lasting psychotic symptoms and impaired cognition, necessitating the need for novel treatment modalities. Recent work in transcranial magnetic stimulation suggests moderate efficacy in symptom reduction in adult patients with schizophrenia; however, the transcranial magnetic stimulation treatment is cumbersome for this severely ill population. Transcranial direct current stimulation may provide a safe and effective adjuvant treatment for continued residual symptoms of schizophrenia.
authors.affiliation: Child Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Building 10, Room 3N202, 10 Center Drive, Bethesda, MD 20890, USA.
authors.forename: Christopher N
authors.initials: CN
authors.lastname: David
authors.forename: Judith L
authors.initials: JL
authors.lastname: Rapoport
authors.forename: Nitin
authors.initials: N
authors.lastname: Gogtay
mesh_terms: D002648:Child; D004599:Electric Stimulation Therapy; D006801:Humans; D011618:Psychotic Disorders / Q000628:therapy*; D012561:Schizophrenia, Childhood / Q000628:therapy*
references.citation: Acta Psychiatr Scand. 2007 Feb;115(2):93-100
references.pmid: 17244172
references.citation: Schizophr Bull. 1994;20(4):647-69
references.pmid: 7701274
references.citation: Schizophr Bull. 2013 May;39(3):601-7
references.pmid: 22419195
references.citation: Eur J Neurol. 2006 Sep;13(9):996-1001
references.pmid: 16930367
references.citation: Schizophr Bull. 2013 Jan;39(1):52-8
references.pmid: 21613381
references.citation: Brain Stimul. 2008 Oct;1(4):370-82
references.pmid: 20633395
references.citation: Int J Alzheimers Dis. 2012;2012:687909
references.pmid: 22114748
references.citation: Clin Neurophysiol. 2012 Apr;123(4):644-57
references.pmid: 21978654
references.citation: Eur J Neurosci. 2006 Mar;23(6):1651-7
references.pmid: 16553629
references.citation: Clin Neurophysiol. 2003 Nov;114(11):2220-2; author reply 2222-3
references.pmid: 14580622
references.citation: J Child Adolesc Psychopharmacol. 2002 Winter;12(4):347-9
references.pmid: 12625995
references.citation: Eur Arch Psychiatry Clin Neurosci. 2012 Aug;262(5):415-23
references.pmid: 22318337
references.citation: J Am Acad Child Adolesc Psychiatry. 2011 Jul;50(7):681-686.e3
references.pmid: 21703495
references.citation: J Child Adolesc Psychopharmacol. 2003 Fall;13(3):401-4
references.pmid: 14642024
references.citation: J Physiol. 1962 Apr;161:73-90
references.pmid: 13906736
references.citation: Am J Psychiatry. 2012 Jul;169(7):719-24
references.pmid: 22581236
references.citation: J Am Acad Child Adolesc Psychiatry. 1992 Sep;31(5):968-76
references.pmid: 1400132
references.citation: Neurotherapeutics. 2008 Apr;5(2):345-61
references.pmid: 18394576
references.citation: J Child Psychol Psychiatry. 1988 Nov;29(6):865-78
references.pmid: 3235494
references.citation: Nature. 1968 Oct 26;220(5165):383-4
references.pmid: 4300961
references.citation: Exp Brain Res. 2012 Jan;216(1):1-10
references.pmid: 21989847
references.citation: Nature. 1962 Nov 10;196:584-5
references.pmid: 13968314
references.citation: Proc Natl Acad Sci U S A. 1956 Sep;42(9):687-94
references.pmid: 16589932
references.citation: Br J Psychiatry. 1995 Apr;166(4):489-95
references.pmid: 7795921
references.citation: Schizophr Res. 2011 Sep;131(1-3):198-205
references.pmid: 21745726
references.citation: Acta Psychiatr Scand. 2007 Jan;115(1):4-11
references.pmid: 17201860
references.citation: Neuroreport. 1998 Jul 13;9(10):2257-60
references.pmid: 9694210
references.citation: Cephalalgia. 2007 Jul;27(7):833-9
references.pmid: 17498207
references.citation: Clin Neurophysiol. 2008 Nov;119(11):2636-40
references.pmid: 18786856
references.citation: J Child Psychol Psychiatry. 1988 Jul;29(4):477-88
references.pmid: 3215919
references.citation: Mol Psychiatry. 2005 May;10(5):434-49
references.pmid: 15700048
references.citation: Brain Stimul. 2011 Oct;4(4):275-80
references.pmid: 22032743
references.citation: Neuropsychologia. 2004;42(1):113-7
references.pmid: 14615081
references.citation: Brain Res Bull. 2007 May 30;72(4-6):208-14
references.pmid: 17452283
references.citation: Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:6481-4
references.pmid: 19964438
references.citation: Int J Neuropsychopharmacol. 2008 Mar;11(2):249-54
references.pmid: 17559710
references.citation: Suppl Clin Neurophysiol. 2003;56:249-54
references.pmid: 14677402
references.citation: J Clin Psychiatry. 2006;67 Suppl 9:9-13; discussion 36-42
references.pmid: 16965183
references.citation: Cereb Cortex. 2008 Feb;18(2):451-5
references.pmid: 17584853
references.citation: J Am Acad Child Adolesc Psychiatry. 1991 May;30(3):457-65
references.pmid: 2055884
references.citation: Exp Neurol. 2009 Sep;219(1):14-9
references.pmid: 19348793
references.citation: Brain Res. 1995 Jul 3;684(2):206-8
references.pmid: 7583224
references.citation: Brain Stimul. 2009 Jan;2(1):14-21
references.pmid: 20633399
references.citation: J Neurol Sci. 2006 Nov 1;249(1):31-8
references.pmid: 16843494
references.citation: Annu Rev Biomed Eng. 2007;9:527-65
references.pmid: 17444810
references.citation: Mov Disord. 2006 Oct;21(10):1693-702
references.pmid: 16817194
references.citation: Nat Clin Pract Neurol. 2007 Jul;3(7):383-93
references.pmid: 17611487
references.citation: Neurosci Lett. 2012 Mar 14;512(1):33-7
references.pmid: 22327036
references.citation: Schizophr Res. 2004 Nov 1;71(1):43-7
references.pmid: 15374571
references.citation: Arthritis Rheum. 2006 Dec;54(12):3988-98
references.pmid: 17133529
references.citation: Biol Psychiatry. 1999 Nov 15;46(10):1418-28
references.pmid: 10578456
references.citation: Exp Gerontol. 2011 Aug;46(8):611-27
references.pmid: 21511025
references.citation: Arch Neurol. 2008 Dec;65(12):1571-6
references.pmid: 19064743
references.citation: Brain Stimul. 2012 Jul;5(3):231-241
references.pmid: 21840287
references.citation: Restor Neurol Neurosci. 2007;25(2):123-9
references.pmid: 17726271
references.citation: Front Psychiatry. 2011 Jul 18;2:45
references.pmid: 21811474
references.citation: Neuropsychopharmacology. 2010 Jan;35(1):301-16
references.pmid: 19693003
references.citation: J Am Acad Child Adolesc Psychiatry. 1995 Oct;34(10):1273-83
references.pmid: 7592264
references.citation: J Neurosci. 2007 Apr 4;27(14):3807-12
references.pmid: 17409245
references.citation: J Am Acad Child Adolesc Psychiatry. 1989 May;28(3):399-407
references.pmid: 2738007
references.citation: Brain Stimul. 2012 Oct;5(4):475-83
references.pmid: 21945231
references.citation: Brain Stimul. 2012 Oct;5(4):468-74
references.pmid: 21962975
references.citation: Int J Neuropsychopharmacol. 2008 Jun;11(4):563-76
references.pmid: 18241358
references.citation: Nature. 1968 Oct 26;220(5165):382-3
references.pmid: 5684882
references.citation: Br J Psychiatry. 1964 Nov;110:786-99
references.pmid: 14211695
references.citation: Clin Neurophysiol. 2003 Apr;114(4):589-95
references.pmid: 12686266
references.citation: Psychol Med. 2012 Sep;42(9):1791-800
references.pmid: 22236735
references.citation: Int J Dev Neurosci. 2011 May;29(3):251-8
references.pmid: 20955775
references.citation: Neurosci Lett. 2006 May 1;398(1-2):85-90
references.pmid: 16448754
references.citation: Schizophr Res. 2005 Mar 1;73(2-3):243-52
references.pmid: 15653267
references.citation: J Physiol. 2000 Sep 15;527 Pt 3:633-9
references.pmid: 10990547
references.citation: Am J Psychiatry. 2005 Mar;162(3):441-9
references.pmid: 15741458
references.citation: Expert Rev Med Devices. 2008 Nov;5(6):759-68
references.pmid: 19025351
references.citation: Am J Psychiatry. 2003 Mar;160(3):490-5
references.pmid: 12611830
references.citation: Schizophr Res. 2010 Jan;116(1):44-8
references.pmid: 19913390
references.citation: Schizophr Bull. 1994;20(4):599-617
references.pmid: 7701271
references.citation: Neurology. 2005 Mar 8;64(5):872-5
references.pmid: 15753425
references.citation: J Neurosci. 2004 Nov 3;24(44):9985-92
references.pmid: 15525784
references.citation: Cerebrovasc Dis. 2007;24 Suppl 1:157-66
references.pmid: 17971652
references.citation: Restor Neurol Neurosci. 2011;29(6):463-92
references.pmid: 22085959
references.citation: Brain Stimul. 2012 Jul;5(3):431-432
references.pmid: 22037120
references.citation: Trends Cogn Sci. 2005 Nov;9(11):503-5
references.pmid: 16182596
references.citation: Biol Psychiatry. 2004 May 15;55(10):989-94
references.pmid: 15121482
references.citation: Brain Stimul. 2008 Jan;1(1):44-51
references.pmid: 19424459
references.citation: Brain Stimul. 2012 Jul;5(3):175-195
references.pmid: 22037126
references.citation: Curr Treat Options Neurol. 2008 Sep;10(5):377-85
references.pmid: 18782510
references.citation: Schizophr Bull. 2008 Jan;34(1):30-6
references.pmid: 17906336
references.citation: Clin Neurophysiol. 2011 Dec;122(12):2384-9
references.pmid: 21665534
references.citation: Exp Neurol. 1962 Jun;5:436-52
references.pmid: 13882165
references.citation: Clin Neurophysiol. 2009 Jan;120(1):80-4
references.pmid: 19027357
references.citation: Pharmacopsychiatry. 2006 Sep;39(5):161-70
references.pmid: 16944406
references.citation: IEEE Trans Biomed Eng. 1990 Oct;37(10):996-1001
references.pmid: 2249872
references.citation: Exp Brain Res. 2005 Sep;166(1):23-30
references.pmid: 15999258
references.citation: J Am Acad Child Adolesc Psychiatry. 1999 May;38(5):537-45
references.pmid: 10230185
references.citation: J Child Psychol Psychiatry. 2006 Oct;47(10):1003-12
references.pmid: 17073979
references.citation: Curr Psychiatry Rep. 2005 Apr;7(2):81-2
references.pmid: 15802082
references.citation: Exp Neurol. 2007 Mar;204(1):462-6
references.pmid: 17113079
references.citation: Eur J Pain. 2012 Aug;16(7):974-82
references.pmid: 22337597
references.citation: Clin Neurophysiol. 2010 Dec;121(12):2165-71
references.pmid: 20554472
references.citation: Psychiatry Clin Neurosci. 1995 Dec;49(5-6):295-8
references.pmid: 8726117
references.citation: Neurology. 2001 Nov 27;57(10):1899-901
references.pmid: 11723286
references.citation: Arch Gen Psychiatry. 2006 Jul;63(7):721-30
references.pmid: 16818861
references.citation: J Am Acad Child Adolesc Psychiatry. 2008 Oct;47(10):1133-40
references.pmid: 18724254
references.citation: Exp Neurol. 1995 May;133(1):25-31
references.pmid: 7601260
references.citation: Curr Opin Psychiatry. 2009 May;22(3):306-11
references.pmid: 19339889
references.citation: Am J Psychiatry. 2000 May;157(5):794-800
references.pmid: 10784474
references.citation: J Cogn Neurosci. 2003 May 15;15(4):619-26
references.pmid: 12803972
references.citation: Clin Neurophysiol. 2006 Apr;117(4):845-50
references.pmid: 16427357
references.citation: Arch Gen Psychiatry. 2001 Jun;58(6):581-8
references.pmid: 11386988
references.citation: Am J Psychiatry. 2000 Oct;157(10):1652-9
references.pmid: 11007720
references.citation: Brain Stimul. 2009 Oct;2(4):241-5
references.pmid: 20633424
references.citation: Arch Gen Psychiatry. 1996 Dec;53(12):1090-7
references.pmid: 8956674