title: Renal histopathological findings in dogs with visceral leishmaniasis.
abstract: Visceral leishmaniasis affects various organs including the kidneys; which can lead to renal failure and death. In order to verify this renal involvement, material was evaluated from 100 dogs naturally infected and with serological diagnosis of canine visceral leishmaniasis (CVL). Inflammatory changes were present in 25.3% of the tubules, in 67.0% of interstitium and in 52.0% of glomeruli. There was no significant difference (p > 0.05) between the presence of glomerulonephritis in symptomatic and oligosymptomatic dogs. The membranous and membranoproliferative glomerulonephritis were the most frequent, both with 18.0% frequency, followed by focal segmental glomerulosclerosis with 14.0%. Changes such as cylindruria, tubular and fibrosis hypertrophy, periglomerular inflammatory infiltrate, and multifocal and diffuse peritubular inflammatory infiltrate were observed. The findings are consistent with those of other authors indicating that renal involvement is common in CVL and the standards of membranous and membranoploriferative glomerulonephritis, as well as the tubulointerstitial involvement, are frequent.
authors.affiliation: Universidade Federal de Mato Grosso do Sul. lrigo@terra.com.br
authors.forename: Rosangela Silva
authors.initials: RS
authors.lastname: Rigo
authors.forename: Cristiano Marcelo Espínola
authors.initials: CM
authors.lastname: Carvalho
authors.forename: Michael Robin
authors.initials: MR
authors.lastname: Honer
authors.forename: Gisele Braziliano de
authors.initials: GB
authors.lastname: Andrade
authors.forename: Iandara Shetter
authors.initials: IS
authors.lastname: Silva
authors.forename: Leonardo
authors.initials: L
authors.lastname: Rigo
authors.forename: Helen Rezende
authors.initials: HR
authors.lastname: Figueiredo
authors.forename: Wanessa Teixeira Gomes
authors.initials: WT
authors.lastname: Barreto
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000469:parasitology / Q000473:pathology*; D004285:Dogs; D005260:Female; D005921:Glomerulonephritis / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D007668:Kidney / Q000473:pathology*; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008297:Male