title: OSTEOPONTIN: A KEY LINK BETWEEN IMMUNITY, INFLAMMATION AND THE CENTRAL NERVOUS SYSTEM.
abstract: Osteopontin (OPN) is a pro-inflammatory cytokine that can be secreted from many cells including activated macrophages and T-lymphocytes. Elevated levels of osteopontin in the plasma, cerebrospinal fluid or brain of individuals with neurodegenerative diseases such as multiple sclerosis (MS), Parkinson's and Alzheimer's disease and more recently in HIV-associated neurocognitive disorder has been reported. However, except for the case of MS, little is known regarding the molecular mechanisms by which OPN may exacerbate disease. Alternatively, OPN through its ability to promote cell survival may in some contexts function in the brain in a protective capacity. OPN has several protein motifs that allow it to engage with several different signaling pathways involved in immunity and inflammation. A better understanding of the cellular pathways that are regulated by OPN in cells of the central nervous system is required to uncover its putative role in neuronal homeostasis.
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Brown
keywords: CD44; HIV-associated neurocognitive disorder; Integrin; Macrophage; Microglia; Neurodegeneration
references.citation: Neurobiol Aging. 2010 May;31(5):747-57
references.pmid: 18657882
references.citation: AIDS Rev. 2005 Jul-Sep;7(3):168-80
references.pmid: 16302465
references.citation: Science. 1996 Jan 26;271(5248):509-12
references.pmid: 8560266
references.citation: Infect Immun. 1999 Aug;67(8):4223-30
references.pmid: 10417195
references.citation: Stroke. 2011 Aug;42(8):2294-301
references.pmid: 21700938
references.citation: AIDS Rev. 2010 Apr-Jun;12(2):103-12
references.pmid: 20571604
references.citation: Neurobiol Dis. 2007 Mar;25(3):473-82
references.pmid: 17188882
references.citation: Clin Chem. 2009 May;55(5):895-903
references.pmid: 19325010
references.citation: Hum Gene Ther. 2007 Dec;18(12):1205-14
references.pmid: 17988193
references.citation: Mol Med Rep. 2008 Sep-Oct;1(5):757-61
references.pmid: 21479482
references.citation: Mol Cell Proteomics. 2010 Dec;9(12):2783-95
references.pmid: 20724469
references.citation: Development. 1997 Sep;124(17):3375-84
references.pmid: 9310332
references.citation: J Comp Neurol. 2009 Dec 20;517(6):906-24
references.pmid: 19844997
references.citation: Crit Rev Oral Biol Med. 2000;11(3):279-303
references.pmid: 11021631
references.citation: Brain Res. 2000 Apr 28;863(1-2):276-81
references.pmid: 10773219
references.citation: Nat Immunol. 2006 May;7(5):498-506
references.pmid: 16604075
references.citation: Neurosci Lett. 1999 Oct 1;273(2):73-6
references.pmid: 10505619
references.citation: J Tissue Eng Regen Med. 2013 May;7(5):392-400
references.pmid: 22392849
references.citation: J Pharmacol Sci. 2006 Mar;100(3):189-94
references.pmid: 16518076
references.citation: J Neurovirol. 2011 Feb;17(1):3-16
references.pmid: 21174240
references.citation: Curr HIV/AIDS Rep. 2012 Mar;9(1):16-25
references.pmid: 22179898
references.citation: J Immunol. 2011 Dec 1;187(11):5671-83
references.pmid: 22021613
references.citation: J Immunol. 1991 Nov 1;147(9):2902-6
references.pmid: 1918998
references.citation: J Leukoc Biol. 2006 Nov;80(5):1127-35
references.pmid: 16923921
references.citation: Crit Rev Immunol. 1993;13(3-4):225-46
references.pmid: 8110377
references.citation: J Immunol. 2002 Mar 1;168(5):2096-9
references.pmid: 11859094
references.citation: Nat Med. 2002 May;8(5):500-8
references.pmid: 11984595
references.citation: Science. 2000 Feb 4;287(5454):860-4
references.pmid: 10657301
references.citation: J Leukoc Biol. 2005 Sep;78(3):675-85
references.pmid: 16000390
references.citation: Neurobiol Dis. 2010 Mar;37(3):542-8
references.pmid: 20044002
references.citation: Neurology. 2007 Oct 30;69(18):1789-99
references.pmid: 17914061
references.citation: Ann Neurol. 1986 Jun;19(6):517-24
references.pmid: 3729308
references.citation: J Neuroimmunol. 2004 Oct;155(1-2):155-60
references.pmid: 15342207
references.citation: J Exp Med. 1989 Jul 1;170(1):145-61
references.pmid: 2787378
references.citation: Curr Alzheimer Res. 2007 Feb;4(1):67-72
references.pmid: 17316167
references.citation: Cell Tissue Res. 1988 Jan;251(1):23-30
references.pmid: 3277715
references.citation: Nat Rev Cancer. 2008 Mar;8(3):212-26
references.pmid: 18292776
references.citation: Nat Immunol. 2007 Jan;8(1):74-83
references.pmid: 17143274
references.citation: J Neurovirol. 2011 Aug;17(4):382-92
references.pmid: 21556958
references.citation: Blood. 2000 Jan 1;95(1):249-55
references.pmid: 10607709
references.citation: J Alzheimers Dis. 2010;19(4):1143-8
references.pmid: 20308780
references.citation: Neurology. 2003 May 13;60(9):1467-73
references.pmid: 12743233
references.citation: Science. 2001 Nov 23;294(5547):1731-5
references.pmid: 11721059
references.citation: J Bone Miner Res. 2003 Sep;18(9):1706-15
references.pmid: 12968681
references.citation: J Neuroimmunol. 2005 Jan;158(1-2):231-9
references.pmid: 15589058
references.citation: J Neurovirol. 2002 Apr;8(2):136-42
references.pmid: 11935465
references.citation: AIDS Rev. 2011 Oct-Dec;13(4):240-50
references.pmid: 21975360
references.citation: Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13848-53
references.pmid: 20643942
references.citation: J Cell Biochem. 2007 Nov 1;102(4):912-24
references.pmid: 17910028
references.citation: Immunol Rev. 2005 Dec;208:207-27
references.pmid: 16313351
references.citation: J Infect Dis. 2012 Jun;205 Suppl 3:S391-8
references.pmid: 22577213
references.citation: FASEB J. 1993 Dec;7(15):1475-82
references.pmid: 8262332
references.citation: Neurology. 2010 Dec 7;75(23):2087-96
references.pmid: 21135382
references.citation: Cells Tissues Organs. 2005;181(3-4):176-88
references.pmid: 16612083
references.citation: Antivir Ther. 2011;16(7):1063-72
references.pmid: 22024522
references.citation: Ann Neurol. 2010 Jun;67(6):699-714
references.pmid: 20517932
references.citation: Brain Res. 2006 Nov 6;1118(1):239-50
references.pmid: 16962083
references.citation: Arch Neurol. 2008 May;65(5):633-5
references.pmid: 18474739
references.citation: Eur J Immunol. 1993 Sep;23(9):2053-8
references.pmid: 7690321
references.citation: Cytokine Growth Factor Rev. 2008 Oct-Dec;19(5-6):333-45
references.pmid: 18952487
references.citation: J Leukoc Biol. 2007 Jun;81(6):1504-11
references.pmid: 17369493
references.citation: J Virol. 2005 Mar;79(6):3509-16
references.pmid: 15731245
references.citation: J Infect Dis. 2008 Sep 1;198(5):715-22
references.pmid: 18616394
references.citation: Nature. 2010 Nov 11;468(7321):253-62
references.pmid: 21068834
references.citation: Discov Med. 2011 May;11(60):385-93
references.pmid: 21616037
references.citation: J Infect Dis. 2008 Jun 1;197(11):1567-76
references.pmid: 18471064
references.citation: Arch Neurol. 2008 Jan;65(1):65-70
references.pmid: 18195140