title: The Role of GABAB Receptors in Morphine Self-Administration.
abstract: BACKGROUND
  There is only little information about the effects of GABA receptors agonist and antagonist on morphine self-administration. Present study was designed to assess role of GABAB receptors in the regulation of morphine-reinforced self-administration.
  
  
  METHODS
  THIS STUDY WAS PERFORMED IN FOUR GROUPS OF RATS: (1) Saline group, which received saline in the self-administration session. (2) Morphine group, which received morphine in saline solution in the self-administration session. (3) Baclofen + Morphine group, which received both baclofen 20 min before self- administration test and morphine in the self-administration session. (4) Phaclofen + Morphine group, which received both phaclofen 20 min before self- administration test and morphine in the self-administration session. The number of lever pressing and self-infusion were recorded.
  
  
  RESULTS
  Morphine significantly increased the number of active lever pressing dose dependently in self-administration session in comparative with saline group. Administration of baclofen, 20 min before morphine self-administration produced significant decrease in the initiation of morphine self-administration during all session. Conversely, pre-treatment of phaclofen increased the number of active lever pressing and self-infusion in this test.
  
  
  CONCLUSIONS
  Our results indicated a short-term treatment by baclofen, reduced morphine-maintenance response in a dose-dependent manner, suggesting that GABAB receptor agonists could be useful for reversing the neuroadaptations related to opiates.
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Effat
authors.initials: E
authors.lastname: Ramshini
authors.forename: Hojjatallah
authors.initials: H
authors.lastname: Alaei
authors.forename: Parham
authors.initials: P
authors.lastname: Reisi
authors.forename: Samaneh
authors.initials: S
authors.lastname: Alaei
authors.forename: Somaye
authors.initials: S
authors.lastname: Shahidani
keywords: Baclofen; morphine addiction; phaclofen; self-administration
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