title: Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients.
abstract: BACKGROUND
  Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders.
  
  
  METHODS
  We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156).
  
  
  RESULTS
  Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding.
  
  
  CONCLUSIONS
  These findings did not survive correction for multiple testing and should be interpreted with caution.
  
  
  CONCLUSIONS
  Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome.
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
authors.forename: Niki
authors.initials: N
authors.lastname: Antypa
authors.forename: Raffaella
authors.initials: R
authors.lastname: Calati
authors.forename: Daniel
authors.initials: D
authors.lastname: Souery
authors.forename: Silvia
authors.initials: S
authors.lastname: Pellegrini
authors.forename: Othman
authors.initials: O
authors.lastname: Sentissi
authors.forename: Daniela
authors.initials: D
authors.lastname: Amital
authors.forename: Ulrike
authors.initials: U
authors.lastname: Moser
authors.forename: Stuart
authors.initials: S
authors.lastname: Montgomery
authors.forename: Siegfried
authors.initials: S
authors.lastname: Kasper
authors.forename: Joseph
authors.initials: J
authors.lastname: Zohar
authors.forename: Diana
authors.initials: D
authors.lastname: De Ronchi
authors.forename: Julien
authors.initials: J
authors.lastname: Mendlewicz
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D003865:Major Depressive Disorder / Q000235:genetics* / Q000523:psychology*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D012917:Social Adjustment
chemical_list: C583518:HTR1A protein, human; D044402:Receptor, Serotonin, 5-HT2A; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A
keywords: Depression; Serotonin genes; Social adjustment