title: Mitophagy in ischaemia/reperfusion induced cerebral injury.
abstract: Mitochondrial autophagy (Mitophagy), the specific autophagic elimination of mitochondria, has been related with several forms of degenerative disease and mitochondrial dysfunction. It is involved in multiple cellular processes. In addition to one of its established key roles in the maintenance of normal cellular phenotype and function, there is growing interest in the concept that targeted modulation of mitophagy may reduce cerebral ischaemia/reperfusion injury. Induction of mitophagy results in selective clearance of damaged mitochondria in cells. In response to stress such as ischaemia/reperfusion, prosurvival and prodeath pathways are concomitantly activated in neuronal cells.
authors.affiliation: Department of Neurology, Shanghai Pudong New Area Zhoupu Hospital, Shanghai, People's Republic of China.
authors.forename: Kangyong
authors.initials: K
authors.lastname: Liu
authors.forename: Yinyi
authors.initials: Y
authors.lastname: Sun
authors.forename: Zhaohua
authors.initials: Z
authors.lastname: Gu
authors.forename: Nan
authors.initials: N
authors.lastname: Shi
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology*; D006801:Humans; D063306:Mitophagy; D015427:Reperfusion Injury / Q000503:physiopathology*
references.citation: Annu Rev Genet. 2009;43:67-93
references.pmid: 19653858
references.citation: Neurobiol Dis. 2008 Jan;29(1):132-41
references.pmid: 17936001
references.citation: Nat Rev Mol Cell Biol. 2011 Jan;12(1):9-14
references.pmid: 21179058
references.citation: Neuroscience. 2012 Feb 17;203:160-9
references.pmid: 22209856
references.citation: Nature. 2006 Oct 19;443(7113):780-6
references.pmid: 17051204
references.citation: Biochem J. 2012 Jan 15;441(2):523-40
references.pmid: 22187934
references.citation: Cell Physiol Biochem. 2011;27(5):613-24
references.pmid: 21691079
references.citation: Biochimie. 2008 Feb;90(2):313-23
references.pmid: 17928127
references.citation: Autophagy. 2010 Nov;6(8):1107-14
references.pmid: 20930570
references.citation: Trends Biochem Sci. 2011 Jan;36(1):30-8
references.pmid: 20728362
references.citation: Circ Res. 2012 Oct 12;111(9):1208-21
references.pmid: 23065344
references.citation: Dev Cell. 2009 Jul;17(1):87-97
references.pmid: 19619494
references.citation: Biochim Biophys Acta. 2013 Jan;1833(1):205-12
references.pmid: 22406072
references.citation: Braz J Med Biol Res. 2012 May;45(5):401-7
references.pmid: 22437482
references.citation: J Biol Chem. 2004 Sep 10;279(37):39068-74
references.pmid: 15247238
references.citation: Gerontology. 2012;58(6):524-30
references.pmid: 22947849
references.citation: Rejuvenation Res. 2005 Spring;8(1):3-5
references.pmid: 15798367
references.citation: CNS Neurosci Ther. 2012 Mar;18(3):250-60
references.pmid: 22449108
references.citation: Cell. 2008 Jan 11;132(1):27-42
references.pmid: 18191218
references.citation: Cell Mol Neurobiol. 2006 Oct-Nov;26(7-8):1057-83
references.pmid: 16710759
references.citation: Biochim Biophys Acta. 2009 Sep;1793(9):1508-15
references.pmid: 19289147
references.citation: Hum Mol Genet. 2009 Oct 15;18(R2):R169-76
references.pmid: 19808793
references.citation: Neurosignals. 2008;16(1):75-84
references.pmid: 18097162
references.citation: Cell Cycle. 2011 Dec 1;10(23):4032-8
references.pmid: 22101267
references.citation: J Biol Chem. 2012 Apr 20;287(17):14088-98
references.pmid: 22389495
references.citation: Acta Pharmacol Sin. 2005 Dec;26(12):1421-34
references.pmid: 16297339
references.citation: Science. 2011 Jan 28;331(6016):456-61
references.pmid: 21205641
references.citation: Autophagy. 2008 Nov;4(8):1057-9
references.pmid: 18776736
references.citation: Trends Pharmacol Sci. 2008 May;29(5):268-75
references.pmid: 18384889
references.citation: Antioxid Redox Signal. 2012 Sep 1;17(5):794-802
references.pmid: 22077334
references.citation: Nature. 2008 Feb 28;451(7182):1069-75
references.pmid: 18305538
references.citation: Nature. 2003 Nov 13;426(6963):127-8
references.pmid: 14614484
references.citation: J Neurosci Res. 2012 Jun;90(6):1183-9
references.pmid: 22345048
references.citation: Mitochondrion. 2010 Jun;10(4):309-15
references.pmid: 20083234
references.citation: Stroke. 2009 Sep;40(9):3149-55
references.pmid: 19478227
references.citation: J Matern Fetal Neonatal Med. 2012 Apr;25 Suppl 1:30-4
references.pmid: 22385271
references.citation: Autophagy. 2010 May;6(4):482-94
references.pmid: 20400854
references.citation: Brain. 2008 Aug;131(Pt 8):1969-78
references.pmid: 18187492
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19500-5
references.pmid: 18048346
references.citation: Nat Chem Biol. 2007 Jun;3(6):331-8
references.pmid: 17486044
references.citation: Pathol Biol (Paris). 1982 May;30(5):269-77
references.pmid: 7048218
references.citation: Cell Death Differ. 2009 Jan;16(1):46-56
references.pmid: 18636076
references.citation: Cell Signal. 2008 Apr;20(4):659-65
references.pmid: 18207367
references.citation: Biol Chem. 2012 Jul;393(7):547-64
references.pmid: 22944659
references.citation: Mol Biol Cell. 2011 Sep;22(17):3206-17
references.pmid: 21757540
references.citation: Trends Cell Biol. 2007 Sep;17(9):422-7
references.pmid: 17804237
references.citation: Neurobiol Dis. 2008 Dec;32(3):329-39
references.pmid: 18760364
references.citation: Genes Dev. 1999 Dec 15;13(24):3271-9
references.pmid: 10617575
references.citation: PLoS One. 2012;7(4):e35324
references.pmid: 22509406
references.citation: J Biol Chem. 1971 Apr 25;246(8):2425-9
references.pmid: 5553400
references.citation: Neurol Res Int. 2012;2012:542976
references.pmid: 22548167
references.citation: Aging (Albany NY). 2009 Apr 09;1(4):425-37
references.pmid: 20157526
references.citation: Yeast. 1996 Jun 15;12(7):623-30
references.pmid: 8810036
references.citation: Neurochem Res. 2013 Jan;38(1):201-7
references.pmid: 23117422
references.citation: Autophagy. 2010 Apr;6(3):366-77
references.pmid: 20168088
references.citation: Dev Cell. 2009 Jul;17(1):98-109
references.pmid: 19619495
references.citation: Apoptosis. 2010 Nov;15(11):1336-53
references.pmid: 20131004
references.citation: Autophagy. 2009 Oct;5(7):1060-1
references.pmid: 19713756
references.citation: Nature. 2008 Jul 10;454(7201):232-5
references.pmid: 18454133