title: Depressive symptoms in first episode psychosis: a one-year follow-up study.
abstract: BACKGROUND
  Depressive symptoms are common in patients with first episode psychosis (FEP) and have serious consequences for them. The main aims of this study were to examine the course of depression in FEP patients and explore whether any patient characteristics at baseline predicts depressive symptoms after one year.
  
  
  METHODS
  A total of 198 FEP patients with schizophrenia spectrum disorders were assessed for depressive symptoms with Calgary Depression Scale for Schizophrenia (CDSS) at baseline and 127 were followed for one year. A CDSS score [greater than or equal to] 6 was used as a cut-off score for depression.
  
  
  RESULTS
  Approximately 50% of the patients were depressed (CDSS[greater than or equal to]6) at baseline. At follow-up approximately 35% had depression. The course of depressive symptoms varied, 26% was depressed at both baseline and follow-up, 9% became depressed during the follow-up, 22% remitted from depression during the 12 months and 43% was neither depressed at baseline nor at follow-up. Poor childhood social functioning, long duration of untreated psychosis (DUP) and depressive symptoms at baseline predicted depression at 12 months follow-up.
  
  
  CONCLUSIONS
  Depressive symptoms are frequent in the first year after onset of psychosis. Patients with poor social functioning in childhood, long DUP and depressive symptoms at baseline are more prone to have depressive symptoms after one year. These patients should be identified and proper treatment provided.
authors.forename: Nasrettin
authors.initials: N
authors.lastname: Sönmez
authors.forename: Kristin Lie
authors.initials: KL
authors.lastname: Romm
authors.forename: Ole A
authors.initials: OA
authors.lastname: Andreasssen
authors.forename: Ingrid
authors.initials: I
authors.lastname: Melle
authors.forename: Jan Ivar
authors.initials: JI
authors.lastname: Røssberg
mesh_terms: D000293:Adolescent; D000328:Adult; D003863:Depression / Q000150:complications* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications* / Q000175:diagnosis; D012565:Schizophrenic Psychology; D012917:Social Adjustment; D055815:Young Adult
references.citation: Schizophr Res. 1994 Feb;11(3):239-44
references.pmid: 8193062
references.citation: Eur Psychiatry. 2012 May;27(4):240-4
references.pmid: 21292455
references.citation: Schizophr Res. 2011 Mar;126(1-3):226-30
references.pmid: 21115328
references.citation: Acta Psychiatr Scand. 2000 Feb;101(2):153-60
references.pmid: 10706017
references.citation: Eur Arch Psychiatry Clin Neurosci. 2005 Jun;255(3):202-12
references.pmid: 15995904
references.citation: Arch Gen Psychiatry. 2008 Jun;65(6):634-40
references.pmid: 18519821
references.citation: Nord J Psychiatry. 2008;62(2):92-105
references.pmid: 18569772
references.citation: Psychiatry Res. 2004 Dec 15;129(2):141-7
references.pmid: 15590041
references.citation: Schizophr Res. 1992 Mar;6(3):201-8
references.pmid: 1571313
references.citation: Compr Psychiatry. 2007 Jan-Feb;48(1):88-94
references.pmid: 17145287
references.citation: Addiction. 1993 Jun;88(6):791-804
references.pmid: 8329970
references.citation: Br J Psychiatry Suppl. 1998;172(33):45-52
references.pmid: 9764126
references.citation: Schizophr Res. 1990 Jul-Aug;3(4):247-51
references.pmid: 2278986
references.citation: Acta Psychiatr Scand. 2010 Sep;122(3):211-8
references.pmid: 19922525
references.citation: Acta Psychiatr Scand. 2011 Mar;123(3):228-38
references.pmid: 21029053
references.citation: J Nerv Ment Dis. 1975 Nov;161(5):307-12
references.pmid: 1185151
references.citation: J Nerv Ment Dis. 1987 Mar;175(3):152-60
references.pmid: 3819711
references.citation: Acta Psychiatr Scand. 2005 Jul;112(1):40-6
references.pmid: 15952944
references.citation: Eur Arch Psychiatry Clin Neurosci. 2005 Jun;255(3):167-73
references.pmid: 15995900
references.citation: Br J Psychiatry Suppl. 1998;172(33):90-2
references.pmid: 9764133
references.citation: Schizophr Bull. 1982;8(3):470-84
references.pmid: 7134891
references.citation: Eur Psychiatry. 2006 Jun;21(4):227-32
references.pmid: 16356690
references.citation: Arch Gen Psychiatry. 1981 Jul;38(7):806-11
references.pmid: 6113822
references.citation: Schizophr Bull. 1987;13(2):261-76
references.pmid: 3616518
references.citation: Am J Psychiatry. 2002 Dec;159(12):2021-6
references.pmid: 12450951
references.citation: Schizophr Res. 1989 May-Jun;2(3):259-64
references.pmid: 2577273
references.citation: J Nerv Ment Dis. 2010 Jan;198(1):67-71
references.pmid: 20061872
references.citation: Br J Psychiatry. 2004 Aug;185:108-15
references.pmid: 15286061
references.citation: Arch Gen Psychiatry. 2011 Oct;68(10):1058-64
references.pmid: 21969462
references.citation: Schizophr Res. 2012 Jan;134(1):20-6
references.pmid: 21937197
references.citation: Eur Addict Res. 2005;11(1):22-31
references.pmid: 15608468
references.citation: Br J Psychiatry. 1995 May;166(5):654-9
references.pmid: 7620753
references.citation: Psychiatry Res. 2011 Aug 30;189(1):55-61
references.pmid: 21196052
references.citation: J Affect Disord. 2012 Sep;140(1):38-47
references.pmid: 22099566
references.citation: Compr Psychiatry. 1988 Sep-Oct;29(5):467-83
references.pmid: 3053027
references.citation: Psychol Med. 2009 Sep;39(9):1447-56
references.pmid: 19187566
references.citation: World J Biol Psychiatry. 2012 Jan;13(1):30-8
references.pmid: 21568628
references.citation: Br J Psychiatry Suppl. 2005 Aug;48:s24-8
references.pmid: 16055803
references.citation: World Psychiatry. 2006 Oct;5(3):172-6
references.pmid: 17139353
references.citation: Schizophr Bull. 1996;22(2):305-26
references.pmid: 8782288