title: Long-term efficacy of transcatheter closure of ventricular septal defect in combination with percutaneous coronary intervention in patients with ventricular septal defect complicating acute myocardial infarction: a multicentre study.
abstract: OBJECTIVE
  To assess the immediate and long-term outcomes of transcatheter closure of ventricular septal defect (VSD) in combination with percutaneous coronary intervention (PCI) in patients with VSD complicating acute myocardial infarction (AMI).
  
  
  RESULTS
  Data were prospectively collected from 35 AMI patients who underwent attempted transcatheter VSD closure and PCI therapy in five high-volume heart centres. All the patients who survived the procedures were followed up by chest x-ray, electrocardiogram and echocardiography. Thirteen patients underwent urgent VSD closure in the acute phase (within two weeks from VSD) while the others underwent elective closure at a median of 23 days from VSD occurrence. The percentage of VSD closure device success was 92.3% (36/39) and procedure success was 91.4% (32/35). The incidence of in-hospital mortality was 14.3% (5/35). At a median of 53 months follow-up, only two patients died at 38 and 41 months, respectively, and other patients' cardiac function tested by echocardiography improved significantly compared to that evaluated before discharge.
  
  
  CONCLUSIONS
  The combination of transcatheter VSD closure and PCI for treating VSD complicating AMI is safe and feasible and is a promising alternative to surgery in patients with anatomically suitable VSD and coronary lesion.
authors.affiliation: Department of Congenital Heart Disease, Shenyang Northern Hospital, Shenyang, China.
authors.forename: Xian-Yang
authors.initials: XY
authors.lastname: Zhu
authors.forename: Yong-Wen
authors.initials: YW
authors.lastname: Qin
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Han
authors.forename: Duan-Zhen
authors.initials: DZ
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Ying-Feng
authors.initials: YF
authors.lastname: Liu
authors.forename: Ya-Wei
authors.initials: YW
authors.lastname: Xu
authors.forename: Quan-Min
authors.initials: QM
authors.lastname: Jing
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
authors.forename: Bernard J
authors.initials: BJ
authors.lastname: Gersh
authors.forename: Xiao-Zeng
authors.initials: XZ
authors.lastname: Wang
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation / Q000401:mortality; D016009:Chi-Square Distribution; D002681:China; D005240:Feasibility Studies; D005260:Female; D017052:Hospital Mortality; D061847:Hospitals, High-Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation / Q000401:mortality; D011446:Prospective Studies; D055989:Septal Occluder Device; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D018658:Ventricular Septal Rupture / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy*