title: Ocular graft-versus-host disease: a review.
abstract: Graft-versus-host disease (GVHD) is a common cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Systemic findings involving the skin, gastrointestinal tract, and liver often overshadow the other manifestations of GVHD. Ocular surface disease remains the most common cause of long-term morbidity in GVHD. Herein, the etiology, pathophysiology, clinical manifestations, and treatment of acute and chronic systemic GVHD are reviewed, with a focus on ocular GVHD.
authors.affiliation: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.
authors.forename: Hasanain
authors.initials: H
authors.lastname: Shikari
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Antin
authors.forename: Reza
authors.initials: R
authors.lastname: Dana
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005128:Eye Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents