title: [The analysis of human papillomavirus infection in lip squamous cell carcinoma patients].
abstract: OBJECTIVE
  To analyze the infection of human papillomavirus in lip squamous cell carcinoma patients.
  
  
  METHODS
  The pathological samples of 9 clinical diagnosed lip cancer patients were collected. Lunimex and PCR techniques were used to detect the HPV gene infection and immunohistochemistry method was used to analyze the HPV protein expression in the samples.
  
  
  RESULTS
  In the 9 cases, 1 was positive for HPV16 gene and 7 were positive for HPV16/18 E6 protein expression. The total positive rate was about 8/9.
  
  
  CONCLUSIONS
  The high HPV infection rate in lip cancer patients in the study indicated indirectly that the importance of the direct contact to the infection of HPV what was the basis for pathogenesis of the lip squamous cell carcinoma.
authors.affiliation: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Head and Neck Surgery Department, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Bao-Yun
authors.initials: BY
authors.lastname: Zhang
authors.forename: Yun-Tao
authors.initials: YT
authors.lastname: Song
authors.forename: Jun-Yong
authors.initials: JY
authors.lastname: Sun
authors.forename: Cao
authors.initials: C
authors.lastname: Chen
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Yu
authors.forename: Guo-Hui
authors.initials: GH
authors.lastname: Xu
authors.forename: Nai-Song
authors.initials: NS
authors.lastname: Zhang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Dong
authors.forename: Qi
authors.initials: Q
authors.lastname: Shi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000302:isolation & purification; D006801:Humans; D008048:Lip Neoplasms / Q000473:pathology / Q000821:virology*; D009367:Neoplasm Staging; D030361:Papillomavirus Infections / Q000453:epidemiology*