title: Impaired atrial electromechanical function and atrial fibrillation promotion in alloxan-induced diabetic rabbits.
abstract: BACKGROUND
  Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). However, the underlying mechanisms are still not clearly elucidated. The aim of this study was to evaluate the atrial electromechanical function, atrial electrophysiological changes and AF inducibility in alloxan-induced diabetic rabbits.
  
  
  METHODS
  In 8 alloxan-induced diabetic rabbits and 8 controls, we evaluated atrial electromechanical function by tissue Doppler imaging. Isolated Langendorff-perfused rabbit hearts were prepared to measure atrial refractory effective period (AERP) and its dispersion (AERPD), interatrial conduction time (IACT) and vulnerability to AF. Atrial interstitial fibrosis was evaluated by Sirius-Red staining.
  
  
  RESULTS
  Compared with controls, left atrial lateral wall Pa'-start interval (Pastart) and right atrial wall Pastart were increased in diabetic rabbits. AERPD was increased and IACT was prolonged in diabetic rabbits. Inducibility of AF in diabetic group was significant higher than controls (6/8 vs. 1/8, p < 0.05). Extensive interstitial fibrosis was observed in the DM group (p < 0.01). Correlation analysis showed that right atrial wall Pastart, Pa'-peak interval (Papeak) and total electromechanical activity (TEMA); left atrial lateral wall Papeak and TEMA, left atrial posterior wall TEMA, and IACT were correlated with atrial areas of fibrosis.
  
  
  CONCLUSIONS
  Atrial electromechanical function is impaired in diabetic rabbits, and is associated with atrial fibrosis and interatrial electrical conduction delay.
authors.forename: Huaying
authors.initials: H
authors.lastname: Fu
authors.forename: Changle
authors.initials: C
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Changyu
authors.initials: C
authors.lastname: Zhou
authors.forename: Lijun
authors.initials: L
authors.lastname: Cheng
authors.forename: Tong
authors.initials: T
authors.lastname: Liu
authors.forename: Guangping
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*; D016275:Atrial Function / Q000502:physiology; D048909:Diabetes Complications / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000503:physiopathology*; D015150:Echocardiography, Doppler; D005260:Female; D005355:Fibrosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D006325:Heart Atria / Q000473:pathology / Q000503:physiopathology; D006329:Heart Conduction System / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D008297:Male; D009206:Myocardium / Q000473:pathology; D010477:Perfusion; D011817:Rabbits