title: Influence of percutaneous local therapy for hepatocellular carcinoma on gastric function.
abstract: OBJECTIVE
  To investigate the influence of percutaneous local therapy on gastric myoelectrical activity in patients with hepatocellular carcinomas.
  
  
  METHODS
  Forty-four patients with hepatocellular carcinoma (HCC) [27 males and 17 females, ranging in age from 49 to 81 years old (69.7 ± 8.01 years)] who were admitted for percutaneous local therapy were enrolled in this study. We examined clinical abdominal symptoms using the Gastrointestinal Symptom Rating Scale (GSRS) before and 3 d after percutaneous local therapy. We also measured cutaneous fasting and postprandial electrogastrography (EGG) recordings before and 3 d after percutaneous local therapy.
  
  
  RESULTS
  We found that the percentage of normogastria in the fasting period was lower in the Child B group than in the Child A group (66.8% ± 8.6% vs 84.0% ± 3.8%). After percutaneous local therapy for HCC, the percentages of normogastria in the fasting period were significantly decreased (81.6% ± 3.5% vs 75.2% ± 4.5%). None of the postprandial EGG parameters changed significantly after percutaneous local therapy for HCC. Percutaneous local therapy for HCC reduced the power ratio (PR). In particular, the PR of tachygastria was significantly decreased after therapy (P < 0.01). However, no significant differences were found in the postprandial EGG parameters. Likewise, no significant differences were found in the calculated GSRS scores obtained from the questionnaire before and after therapy.
  
  
  CONCLUSIONS
  Gastric slow-wave dysrhythmias were induced by percutaneous local therapy in HCC patients, even though the GSRS scores obtained from the questionnaire did not change significantly.
authors.affiliation: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. koba@med.kagawa-u.ac.jp
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kinekawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Matsuda
authors.forename: Shintaro
authors.initials: S
authors.lastname: Fujihara
authors.forename: Noriko
authors.initials: N
authors.lastname: Nishiyama
authors.forename: Takako
authors.initials: T
authors.lastname: Nomura
authors.forename: Joji
authors.initials: J
authors.lastname: Tani
authors.forename: Hisaaki
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Hideki
authors.initials: H
authors.lastname: Kobara
authors.forename: Akihiro
authors.initials: A
authors.lastname: Deguchi
authors.forename: Hirohito
authors.initials: H
authors.lastname: Yoneyama
authors.forename: Hirohito
authors.initials: H
authors.lastname: Mori
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Masaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D017115:Catheter Ablation / Q000009:adverse effects*; D004568:Electrodiagnosis; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007267:Injections; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016065:Myoelectric Complex, Migrating; D011237:Predictive Value of Tests; D012044:Regression Analysis; D013270:Stomach / Q000503:physiopathology*; D013272:Stomach Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000431:Ethanol
keywords: Electrogastrography; Gastric myoelectrical activity; Hepatocellular carcinoma; Percutaneous ethanol injection; Radiofrequency ablation
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