title: Estrogen and progesterone receptors in patients with bladder pain syndrome.
abstract: OBJECTIVE
  Analyze if bladder mucosa of patients with bladder pain syndrome (BPS) have more estrogen receptor (ER) and progesterone receptor (PR) than the normal population.
  
  
  METHODS
  Between July 2009 and December 2010, 15 female patients with chronic bladder pain syndrome and 10 female patients without bladder pain were enrolled in the present study. Three pieces of trigonal bladder mucosa were biopsied and sent for estrogen receptor and progesterone receptor immunohistochemistry staining by the Benchmark automated machine. The results were reported as positive and negative and then compared between the two groups.
  
  
  RESULTS
  Estrogen receptor was found in 14 out of 15 patients in the BPS group (93%) and in 7 out of 10 patients in the control group (70%). Progesterone receptor was found in 10 out of 15 patients in the BPS group (66.7%) and 5 out of 10 patients in the control group. Both were not significantly different with p = 0.267 and p = 0.678, respectively.
  
  
  CONCLUSIONS
  The authors concluded that ER and PR might not play a role in the etiopathogenesis of BPS/IC. However other receptors should be further investigated about their role in this type of pain.
authors.affiliation: Urology Division, Department of Surgery, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand. pokket_u@hotmail.com
authors.forename: Pokket
authors.initials: P
authors.lastname: Ungbhakorn
authors.forename: Panus
authors.initials: P
authors.lastname: Chalermsanyakorn
authors.forename: Supannee
authors.initials: S
authors.lastname: Nilskulwat
authors.forename: Wachira
authors.initials: W
authors.lastname: Kochakarn
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D016022:Case-Control Studies; D018856:Cystitis, Interstitial / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D003558:Cystoscopy; D004106:Dilatation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D017699:Pelvic Pain / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D013577:Syndrome; D001743:Urinary Bladder / Q000473:pathology; D014555:Urination Disorders / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D055815:Young Adult
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone