title: High-throughput optimization of Ir-catalyzed C-H borylation: a tutorial for practical applications.
abstract: With the aid of high-throughput screening, the efficiency of Ir-catalyzed C-H borylations has been assessed as functions of precatalyst, boron reagent, ligand, order of addition, temperature, solvent, and substrate. This study not only validated some accepted practices but also uncovered unconventional conditions that were key to substrate performance. We anticipate that insights drawn from these findings will be used to design reaction conditions for substrates whose borylations are difficult to impossible using standard catalytic conditions.
authors.affiliation: Department of Chemistry, Michigan State University, East Lansing, Michigan 48824-1322, USA.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Preshlock
authors.forename: Behnaz
authors.initials: B
authors.lastname: Ghaffari
authors.forename: Peter E
authors.initials: PE
authors.lastname: Maligres
authors.forename: Shane W
authors.initials: SW
authors.lastname: Krska
authors.forename: Robert E
authors.initials: RE
authors.lastname: Maleczka
authors.forename: Milton R
authors.initials: MR
authors.lastname: Smith
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D057166:High-Throughput Screening Assays; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D001896:Boron Compounds; D009942:Organometallic Compounds; D007495:Iridium