title: Cognitive and psychosocial development concerns in children born small for gestational age.
abstract: Outcome information for infants born small for gestational age (SGA), whether term or premature, suggests poorer cognitive function compared with appropriate size for gestational age (AGA) infants. Poorer outcome is associated with smaller size for gestational age and with lack of catch-up growth after birth. Such data have been reported from early childhood to young adulthood. Diminished head circumference at birth and growth thereafter has also been associated with poor outcome. Based on available reports, the impact of SGA birth upon psychosocial development remains unclear. While it has not been shown that growth hormone (GH) therapy impacts either cognitive or psychosocial outcome, increased head circumference standard deviation scores have been shown to occur with GH therapy. These data need to be interpreted with caution since study populations do not define etiology of SGA and definitions of SGA vary. Further, generalized group data are not applicable to individuals.
authors.affiliation: Department of Pediatrics, Penn State College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033-0850, USA. plee@psu.edu
authors.forename: Peter A
authors.initials: PA
authors.lastname: Lee
authors.forename: Christopher P W
authors.initials: CP
authors.lastname: Houk
mesh_terms: D002508:Cephalometry; D002657:Child Development / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control; D006257:Head / Q000254:growth & development*; D019382:Human Growth Hormone / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000254:growth & development*
chemical_list: D019382:Human Growth Hormone