title: A diverted total syntheses of potent cell adhesion inhibitor peribysin E analogues.
abstract: Preliminary results from a program aimed at the creation of a focused library of analogues around the natural product peribysin E, a potent biologically active and structurally fascinating molecule, are reported. The total synthesis of (±)-peribysin E was accomplished using a short route. Eight new analogues of the natural compound have been accomplished by means of "diverted total synthesis" in less than 10 steps. The present effort highlights protecting-group-free total syntheses and the shortest route to access these functionally embellished hydrindanes.
authors.affiliation: CSIR-National Chemical Laboratory, Division of Organic Chemistry, Dr. Homi Bhabha Road, Pune, 411008, India.
authors.forename: Kishor L
authors.initials: KL
authors.lastname: Handore
authors.forename: D Srinivasa
authors.initials: DS
authors.lastname: Reddy
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D007189:Indans; C501235:peribysin E