title: Advance in herpes simplex viruses for cancer therapy.
abstract: Oncolytic virotherapy is an attractive approach that uses live viruses to selectively kill cancer cells. Oncolytic viruses can be genetically engineered to induce cell lyses through virus replication and cytotoxic protein expression. Herpes simplex virus (HSV) has become one of the most widely clinically used oncolytic agent. Various types of HSV have been studied in basic or clinical research. Combining oncolytic virotherapy with chemotherapy or radiotherapy generally produces synergic action with unclear molecular mechanisms. Arming HSV with therapeutic transgenes is a promising strategy and can be used to complement conventional therapies. As an efficient gene delivery system, HSV has been successfully used to deliver various immunomodulatory molecules. Arming HSV with therapeutic genes merits further investigation for potential clinical application.
authors.affiliation: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Shanglong
authors.initials: S
authors.lastname: Liu
authors.forename: Meihua
authors.initials: M
authors.lastname: Dai
authors.forename: Lei
authors.initials: L
authors.lastname: You
authors.forename: Yupei
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000235:genetics; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics / Q000628:therapy* / Q000821:virology; D050130:Oncolytic Virotherapy / Q000379:methods*; D050504:Oncolytic Viruses / Q000235:genetics* / Q000502:physiology; D018139:Simplexvirus / Q000235:genetics* / Q000502:physiology