title: Inducible graphene oxide probe for high-specific tumor diagnosis.
abstract: A revolutionary probe was constructed by conjugating Cy5 on a graphene oxide sheet. The fluorescence was quenched owing to its proximity to graphene oxide in normal circumstances, but lit on arriving at the tumor site. Both in vitro and in vivo studies demonstrated that the probe exhibits great potential for tumor diagnosis.
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Zhanguo
authors.initials: Z
authors.lastname: Yue
authors.forename: Piping
authors.initials: P
authors.lastname: Lv
authors.forename: Hua
authors.initials: H
authors.lastname: Yue
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Gao
authors.forename: Ding
authors.initials: D
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Guanghui
authors.initials: G
authors.lastname: Ma
mesh_terms: D000818:Animals; D002232:Carbocyanines; D018827:Carcinoma, Lewis Lung / Q000175:diagnosis* / Q000473:pathology; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D005456:Fluorescent Dyes; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D015552:Injections, Intralesional; D008301:Maleimides / Q000737:chemistry; D045726:Metalloproteases / Q000032:analysis* / Q000037:antagonists & inhibitors; D051379:Mice; D057054:Molecular Imaging; D015335:Molecular Probes / Q000138:chemical synthesis*; D053758:Nanoparticles / Q000737:chemistry; D009363:Neoplasm Proteins / Q000032:analysis* / Q000037:antagonists & inhibitors; D009842:Oligopeptides / Q000138:chemical synthesis; D010087:Oxides; D054730:Protein Interaction Domains and Motifs; D013050:Spectrometry, Fluorescence
chemical_list: D002232:Carbocyanines; D004791:Enzyme Inhibitors; D005456:Fluorescent Dyes; D008301:Maleimides; D015335:Molecular Probes; D009363:Neoplasm Proteins; D009842:Oligopeptides; D010087:Oxides; C085321:cyanine dye 5; D006108:Graphite; D045726:Metalloproteases