title: Pubertal height velocity and associations with prepubertal and adult heights in cystic fibrosis.
abstract: OBJECTIVE
  To test the hypothesis that pubertal peak height velocity (PHV) in cystic fibrosis (CF) has improved and is influenced by prepubertal growth and genetic potential.
  
  
  METHODS
  PHV from 1862 children born in 1984-87 and documented in the 1986-2008 US CF Foundation Registry was determined by statistical modeling and classified into normal, delayed (2-SD > average age), attenuated (magnitude <5th percentile), or both delayed and attenuated (D&A). Genetic potential for height was estimated by parental stature.
  
  
  RESULTS
  PHV averaged 8.4 cm/year at age 14.0 years in boys and 7.0 cm/year at age 12.1 years in girls, ∼6-month delay and ∼15% reduction compared with healthy children. PHV was normal in 60%, delayed in 9%, attenuated in 21%, and D&A in 5%. Patients with delayed PHV reached similar adult height percentile (boys: 34th, girls: 46th) to those with normal PHV (boys: 33rd, girls: 34th); both were significantly taller than the attenuated (boys: 11th, girls: 19th) and D&A PHV subgroups (boys: 8th, girls: 14th). Pancreatic-sufficient patients had taller prepubertal and adult heights but similar PHV compared with pancreatic-insufficient or meconium ileus patients. Adjusting for genetic potential reduced adult height percentiles more in boys (from 25th to 16th) than girls (from 28th to 24th). Height at age 7 years, PHV age and magnitude, and parental stature significantly predicted adult height.
  
  
  CONCLUSIONS
  Pubertal PHV has improved in children with CF born after mid-1980s compared with older cohorts but remains below normal. Suboptimal prepubertal and pubertal growth led to adult height below genetic potential in CF.
authors.affiliation: Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: Zhumin
authors.initials: Z
authors.lastname: Zhang
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Lindstrom
authors.forename: HuiChuan J
authors.initials: HJ
authors.lastname: Lai
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001827:Body Height / Q000235:genetics; D002648:Child; D003550:Cystic Fibrosis / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011627:Puberty; D013997:Time Factors; D055815:Young Adult
keywords: BMI; Body mass index; CF; CF Foundation; CFF; Cystic fibrosis; D&A; Delayed and attenuated; HV; Height velocity; MI; Meconium ileus; PHV; PI; PS; Pancreatic insufficiency; Pancreatic sufficiency; Peak height velocity
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