title: Platelet-rich plasma limits the nerve injury caused by 10% dextrose in the rabbit median nerve.
abstract: BACKGROUND
  We evaluated the effect of platelet-rich plasma (PRP) injection in a rabbit model of dextrose-induced median nerve injury.
  
  
  METHODS
  New Zealand white rabbits (n = 15) were divided randomly into 3 groups. Three different regimens (group 1: 0.1 ml saline; group 2: 10% dextrose with PRP; group 3: 10% dextrose with saline) were injected within the carpal tunnel. Electrophysiological and histological findings were evaluated 12 weeks after the injection.
  
  
  RESULTS
  The mean median motor latency in group 3 was significantly longer than that in groups 1 and 2. The cross-sectional area of the median nerve and subsynovial connective tissue thickness in group 3 were significantly larger than those in groups 1 and 2.
  
  
  CONCLUSIONS
  PRP injection may be effective in controlling median nerve injury, as demonstrated by improvement in electrophysiological and histological findings 12 weeks after dextrose injection.
authors.affiliation: Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, 33 Duryugongwon-ro 17-gil, Nam-Gu, Daegu, 705-718, Korea.
authors.forename: Gi-Young
authors.initials: GY
authors.lastname: Park
authors.forename: Dong Rak
authors.initials: DR
authors.lastname: Kwon
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000473:pathology; D005947:Glucose / Q000009:adverse effects*; D007267:Injections; D008297:Male; D008475:Median Nerve / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D020423:Median Neuropathy / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D023421:Models, Animal; D053657:Platelet-Rich Plasma; D011817:Rabbits; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D005947:Glucose
keywords: carpal tunnel; dextrose; median nerve; platelet-rich plasma; rabbit