title: Isolated oral histoplasmosis presenting as Fever of unknown origin in a Portuguese hemodialysis patient.
abstract: The authors report a clinical case of an isolated oral histoplasmosis in a hemodialysis patient that presented with fever of unknown origin and had an unremarkable physical examination. During the investigation, a Gallium scan showed uptake in the oral cavity and soon after the oral cavity examination revealed a granulomatous lesion on the tooth 26. Histopathologic findings were compatible with histoplasmosis. The treatment regimen included liposomal amphotericin B followed by itraconazole consolidation therapy, and side effects did not occur. Both clinical evolution and outcome were favorable. Oral histoplasmosis in a non-immunosuppressed patient is extremely rare.
authors.affiliation: Infectious Diseases Unit, University Hospitals of Coimbra, Praceta Prof. Mota Pinto, 3000-075, Coimbra, Portugal. lusonmar@hotmail.com
authors.forename: Nuno
authors.initials: N
authors.lastname: Marques
authors.forename: Ana
authors.initials: A
authors.lastname: Lebre
authors.forename: Francisco
authors.initials: F
authors.lastname: Marques
authors.forename: Maria
authors.initials: M
authors.lastname: Julião
authors.forename: Luís
authors.initials: L
authors.lastname: Freitas
authors.forename: Lurdes
authors.initials: L
authors.lastname: Malcata
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rabadão
authors.forename: José Saraiva
authors.initials: JS
authors.lastname: da Cunha
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D005335:Fever of Unknown Origin / Q000209:etiology* / Q000382:microbiology*; D005881:Gingiva / Q000473:pathology*; D006651:Histocytochemistry; D006660:Histoplasmosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D011174:Portugal; D006435:Renal Dialysis
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D017964:Itraconazole; D000666:Amphotericin B
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