title: Delivery of plasmid DNA to mammalian cells using polymer-gold nanorod assemblies.
abstract: Functionalized and surface-modified gold nanorods (GNRs) have emerged as promising vehicles for the delivery of several therapeutic agents. Ease of functionalization, increased stability, biocompatibility, and size-dependent plasmonic properties make gold nanorods attractive in sensing, imaging, and delivery to different cellular types. Here, we demonstrate the use of polyelectrolyte-coated GNRs (PE-GNRs) for delivering plasmid DNA to mammalian cells for transgene expression.
authors.affiliation: School of Biological and Health Systems & Chemical Engineering, Center for the Convergence of Physical Science and Cancer Biology, Arizona State University, Tempe, AZ, USA.
authors.forename: James
authors.initials: J
authors.lastname: Ramos
authors.forename: Huang-Chiao
authors.initials: HC
authors.lastname: Huang
authors.forename: Kaushal
authors.initials: K
authors.lastname: Rege
mesh_terms: D045744:Cell Line, Tumor; D004247:DNA / Q000008:administration & dosage*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008297:Male; D043942:Nanotubes; D010957:Plasmids; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers; D006046:Gold; D004247:DNA