title: Serum prolidase activity in psoriasis patients.
abstract: This study aimed to evaluate serum prolidase activity and the effects of gender, body mass index (BMI), disease severity and duration, and therapy type on prolidase activity in patients with psoriatic as well as the relationship between serum NO· and prolidase levels in these patients. The study included 29 clinically documented plaque patients with psoriasis and 24 healthy volunteers. Data such as age, sex, BMI, duration and severity of disease, and type of therapy were assessed. NO· levels were determined by the Griess reaction. Serum prolidase assay is based on a colorimetric determination of proline by Chinard's reagent. We did not determine any difference in serum NO· levels of psoriatic patients when compared to controls. Serum prolidase levels in psoriasis patients were significantly higher than those in controls. There was no significant difference in prolidase activity between male and female. No statistically significant correlations were found between serum prolidase levels and BMI, PASI and disease duration. When compared between topical treatment group and systemic treatment group, there was no significant difference in serum prolidase activity. In conclusion, patients with psoriasis exhibit higher serum prolidase activity independent of gender, BMI, disease severity or duration, type of treatments or NO· level. However, further studies are needed to verify these findings as well as altered collagen synthesis in patients with psoriasis.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey. berrak_guven@hotmail.com
authors.forename: Berrak
authors.initials: B
authors.lastname: Guven
authors.forename: Murat
authors.initials: M
authors.lastname: Can
authors.forename: Mehmet
authors.initials: M
authors.lastname: Genc
authors.forename: Rafet
authors.initials: R
authors.lastname: Koca
mesh_terms: D004150:Dipeptidases; D006801:Humans; D008727:Methotrexate; D011701:PUVA Therapy; D011565:Psoriasis / Q000628:therapy*
chemical_list: D004150:Dipeptidases; C022449:proline dipeptidase; D008727:Methotrexate