title: A matter of balance: role of neurexin and neuroligin at the synapse.
abstract: Neurexins and neuroligins are synaptic cell adhesion molecules. Neurexins are primary located on the presynaptic membrane, whereas neuroligins are strictly postsynaptic proteins. Since their discovery, the knowledge of neurexins and neuroligins has expanded, implicating them in various neuronal processes, including the differentiation, maturation, stabilization, and plasticity of both inhibitory and excitatory synapses. Here, we review the most recent results regarding the structure and function of these cell adhesion molecules.
authors.affiliation: The Protein Laboratory, Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, Blegdamsvej 3C, Building 24.2, 2200 Copenhagen, Denmark.
authors.forename: Marie Louise
authors.initials: ML
authors.lastname: Bang
authors.forename: Sylwia
authors.initials: S
authors.lastname: Owczarek
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002659:Child Development Disorders, Pervasive / Q000235:genetics; D059330:GABAergic Neurons / Q000502:physiology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011487:Protein Conformation; D012559:Schizophrenia / Q000235:genetics; D013569:Synapses / Q000502:physiology*
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D009419:Nerve Tissue Proteins; C093438:neuroligin 1
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