title: Impact of retransfusion of blood processed in cell-saver on coagulation versus cardiopulmonary bypass: a prospective observational study using thromboelastography.
abstract: OBJECTIVE
  To compare an impact of retransfusion of blood processed in cell-saver (CS) with that of cardiopulmonary bypass (CPB) on blood coagulation in patients undergoing cardiac surgery.
  
  
  METHODS
  Prospective observational study using thromboelastography (TEG).
  
  
  RESULTS
  TEG samples from 170 patients were analyzed. Cardiopulmonary bypass was used in 100 patients while 70 patients were operated off-pump. In 20 off-pump patients collected blood was processed by cell-saver and returned. In all patients clot formation after heparin neutralization by protamine was unimpaired. However, there was a significant increase in fibrinolysis defined by the TEG parameter Lysis time 30 min after the maximum amplitude of the clot was reached (Ly30) in groups with CPB or CS but this increase still did not exceed the threshold for clinical fibrinolysis (Ly30 > 7.5%). In the group without CPB there was no significant impact on coagulation.
  
  
  CONCLUSIONS
  Surgery that avoids CPB and/or CS is the gentlest method for inducing blood coagulation.
authors.affiliation: Department of Anaesthesiology and Intensive Care Medicine, 2nd Medical School, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.
authors.forename: Tomas
authors.initials: T
authors.lastname: Vymazal
authors.forename: Martin
authors.initials: M
authors.lastname: Filaun
authors.forename: Michal
authors.initials: M
authors.lastname: Horacek
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D001803:Blood Transfusion / Q000379:methods*; D002315:Cardiopulmonary Bypass; D006801:Humans; D019106:Postoperative Hemorrhage / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D011446:Prospective Studies; D019233:Retreatment; D013916:Thrombelastography / Q000379:methods*