title: Methotrexate toxicity presenting as cutaneous ulcerations on psoriatic plaques.
abstract: Methotrexate (MTX) is an effective but potentially toxic treatment for psoriasis. We describe a patient who administered 20 mg daily of MTX for 5 d and presented with ulcerated and necrotic lesions on the psoriatic plaques, mouth erosions and hair loss. However, his psoriatic plaques and ulcerations totally healed rapidly within two weeks and no recurrence has been observed for the 6 months of follow up.
authors.affiliation: Department of Dermatology, Dumlup|nar University, Kütahya Evliya C elebi Education and Research Hospital, Kütahya, Turkey. aslihanyy@yahoo.com
authors.forename: Aslıhan Yonca
authors.initials: AY
authors.lastname: Koçak
authors.forename: Oğuzhan
authors.initials: O
authors.lastname: Koçak
authors.forename: Figen
authors.initials: F
authors.lastname: Aslan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tektaş
mesh_terms: D000368:Aged; D005493:Folic Acid Antagonists / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy / Q000473:pathology; D012867:Skin / Q000473:pathology; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology
chemical_list: D005493:Folic Acid Antagonists; D008727:Methotrexate