title: Primitive neuroectodermal tumor (PNET) as somatic-type malignancy arising from an extragonadal germ-cell tumor: clinical, pathological and molecular features of a case.
abstract: We report a rare case of a 34-year-old man with a right axillary mass. Ten years previously, he had been diagnosed with a right scapular nonseminomatous germ-cell tumor consisting of teratoma, completely resected without any further treatment. Presently he was found to have a metastatic malignant small round cell tumor consistent with a secondary somatic malignancy arising in the background of nonseminomatous germ-cell tumor, teratoma, yolk sac tumor, and primitive neuroectodermal tumor with distinct chromosome 22 translocation. Although the patient initially responded well to chemotherapy with etoposide, cisplatin, ifosfamide and mesna, he relapsed shortly after.
authors.affiliation: Department of Oncology, McGill University, Montreal, Quebec, Canada. akgarg2@gmail.com
authors.forename: Amit
authors.initials: A
authors.lastname: Garg
authors.forename: Ayoub
authors.initials: A
authors.lastname: Nahal
authors.forename: Robert
authors.initials: R
authors.lastname: Turcotte
authors.forename: Roger
authors.initials: R
authors.lastname: Tabah
authors.forename: Thierry
authors.initials: T
authors.lastname: Alcindor
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000473:pathology; D002892:Chromosomes, Human, Pair 22; D018240:Endodermal Sinus Tumor / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis* / Q000235:genetics / Q000556:secondary; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis* / Q000235:genetics / Q000556:secondary*; D012540:Scapula; D013724:Teratoma / Q000175:diagnosis* / Q000235:genetics; D013736:Testicular Neoplasms; D014178:Translocation, Genetic