title: Increasing antimicrobial resistance of campylobacter jejuni isolated from paediatric diarrhea cases in a tertiary care hospital of new delhi, India.
abstract: BACKGROUND
  The resistance to the clinically important antimicrobial agents, particularly the fluoroquinolones and the macrolides, is increasing among the Campylobacter isolates. Only limited data is available regarding the changing antimicrobial resistance pattern in the Indian scenario.
  
  
  METHODS
  Three hundred fifty cases (ages ≤12years) of acute diarrhoea, who were admitted to a tertiary-care hospital, were investigated for Campylobacter spp. The antimicrobial susceptibilities of all the C. jejuni isolates were assessed by the disk diffusion method according to the CLSI guidelines.
  
  
  RESULTS
  A total of 36 isolates of C. jejuni were tested for their antimicrobial susceptibilities. A high degree of resistance to the fluoroquinolones (100% to Nalidixic acid and 86.66% to Ciprofloxacin) was detected in the Campylobacter isolates. The frequency of resistance against Tetracycline was 33.33% and that against Erythromycin was 22.2%. Fifteen (41.66%) isolates were multiresistant, being resistant to 3 or more antimicrobial agents.
  
  
  CONCLUSIONS
  An increased resistance to the quinolones and the macrolides and multidrug resistance warrant a reconsideration of their use as the drugs of choice in patients with severe gastroenteritis when Campylobacter is the presumed cause.
authors.affiliation: Post Graduate Student, Department of Microbiology.
authors.forename: Roumi
authors.initials: R
authors.lastname: Ghosh
authors.forename: Beena
authors.initials: B
authors.lastname: Uppal
authors.forename: Prabhav
authors.initials: P
authors.lastname: Aggarwal
authors.forename: Anita
authors.initials: A
authors.lastname: Chakravarti
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Jha
keywords: Campylobacter; Diarrhoea; Food borne; Resistance
references.citation: J Med Microbiol. 2001 Oct;50(10):933-4
references.pmid: 11599745
references.citation: Ann Intern Med. 1979 Aug;91(2):179-85
references.pmid: 380433
references.citation: Trans R Soc Trop Med Hyg. 2005 Mar;99(3):207-14
references.pmid: 15653123
references.citation: Indian J Med Microbiol. 2012 Jan-Mar;30(1):85-8
references.pmid: 22361767
references.citation: Emerg Infect Dis. 1999 Jan-Feb;5(1):28-35
references.pmid: 10081669
references.citation: J Infect Dis. 2004 Sep 15;190(6):1150-7
references.pmid: 15319866
references.citation: J Clin Microbiol. 1999 Nov;37(11):3458-64
references.pmid: 10523534
references.citation: J Infect. 1992 Jan;24(1):55-62
references.pmid: 1548418
references.citation: J Infect Dis. 2005 Apr 1;191(7):1050-5
references.pmid: 15747238
references.citation: Southeast Asian J Trop Med Public Health. 2007 May;38(3):501-6
references.pmid: 17877226
references.citation: Emerg Infect Dis. 2002 Mar;8(3):237-44
references.pmid: 11927019
references.citation: Indian J Med Res. 2001 Jul;114:12-7
references.pmid: 11762201