title: Elevated serum β2-glycoprotein-I-lipoprotein(a) complexes levels are associated with the presence and complications in type 2 diabetes mellitus.
abstract: OBJECTIVE
  To examine the serum levels of β2-glycoprotein I-lipoprotein(a) complexes [β2-GPI-Lp(a)] in type 2 diabetes mellitus (T2DM) patients and evaluate the association of the complexes with complications in T2DM.
  
  
  METHODS
  Fifty two T2DM patients (22 with complications and 30 free of complications) and 52 age/gender-matched healthy controls were studied. Serum concentrations of β2-GPI-Lp(a) and ox-Lp(a) were measured by "sandwich" ELISAs and their associations with complications were examined using multiple linear regression.
  
  
  RESULTS
  Mean serum β2-GPI-Lp(a) (1.19 ± 0.30 U/mL vs. 0.89 ± 0.20 U/mL, p<0.001) and ox-Lp(a) concentrations (13.34 ± 11.73 mg/L vs. 5.26 ± 3.34 mg/L, p<0.001) were both significantly higher in T2DM than in controls. The area under the ROC curve (AUC) for β2-GPI-Lp(a) and ox-Lp(a) was 0.725 and 0.738, respectively. β2-GPI-Lp(a) levels were markedly higher in patients with complications than those without complication (1.39 ± 0.28 U/mL vs. 1.04 ± 0.31 U/mL, p<0.01), whereas no marked difference was found in ox-Lp(a). In multivariate regression analysis, the association between β2-GPI-Lp(a) and complications remained significant (β=0.249, p<0.05, respectively) after adjustments were made for other traits.
  
  
  CONCLUSIONS
  Elevated β2-GPI-Lp(a) may reflect chronic underlying pathophysiological processes involved in development of complications of T2DM.
authors.affiliation: Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing, People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Niu
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.forename: Xiao-Cui
authors.initials: XC
authors.lastname: Guan
authors.forename: Wen
authors.initials: W
authors.lastname: Yang
authors.forename: Jun-Jun
authors.initials: JJ
authors.lastname: Wang
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Zhang
authors.forename: Chun-Ni
authors.initials: CN
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D053482:beta 2-Glycoprotein I / Q000097:blood*
chemical_list: D017270:Lipoprotein(a); D053482:beta 2-Glycoprotein I