title: Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission.
abstract: Relay cells of dorsal lateral geniculate nucleus (LGN) receive a Class 1 glutamatergic input from the retina and a Class 2 input from cortical layer 6. Among the properties of Class 2 synapses is the ability to activate metabotropic glutamate receptors (mGluRs), and mGluR activation is known to affect thalamocortical transmission via regulating retinogeniculate and thalamocortical synapses. Using brain slices, we studied the effects of Group I (dihydroxyphenylglycine) and Group II ((2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine) mGluR agonists on retinogeniculate synapses. We showed that both agonists inhibit retinogeniculate excitatory postsynaptic currents (EPSCs) through presynaptic mechanisms, and their effects are additive and independent. We also found high-frequency stimulation of the layer 6 corticothalamic input produced a similar suppression of retinogeniculate EPSCs, suggesting layer 6 projection to LGN as a plausible source of activating these presynaptic mGluRs.
authors.affiliation: University of Chicago, Department of Neurobiology, 947 E. 58th Street, Chicago, IL 60637, United States. ywlam@uchicago.edu
authors.forename: Y-W
authors.initials: YW
authors.lastname: Lam
authors.forename: S M
authors.initials: SM
authors.lastname: Sherman
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology; D003521:Cyclopropanes / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D005829:Geniculate Bodies / Q000187:drug effects / Q000502:physiology*; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D051379:Mice; D009433:Neural Inhibition / Q000502:physiology*; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D010775:Photic Stimulation; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000502:physiology*; D012118:Resorcinols / Q000494:pharmacology; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D013788:Thalamus / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology
chemical_list: D003521:Cyclopropanes; D018690:Excitatory Amino Acid Agonists; D018094:Receptors, Metabotropic Glutamate; D012118:Resorcinols; C108822:metabotropic glutamate receptor 2; C104077:metabotropic glutamate receptor type 1; C082313:2-(2,3-dicarboxycyclopropyl)glycine; C079215:3,5-dihydroxyphenylglycine; D005998:Glycine
references.citation: J Neurophysiol. 2004 Oct;92(4):2185-97
references.pmid: 15140908
references.citation: J Neurophysiol. 2013 Jan;109(1):113-23
references.pmid: 23076103
references.citation: J Neurosci. 2012 Sep 12;32(37):12820-31
references.pmid: 22973005
references.citation: Neuroscience. 2006;137(2):671-83
references.pmid: 16289833
references.citation: J Neurophysiol. 2005 Oct;94(4):2472-83
references.pmid: 16160090
references.citation: Neuron. 2003 Apr 24;38(2):277-89
references.pmid: 12718861
references.citation: J Neurosci. 2012 May 23;32(21):7364-72
references.pmid: 22623682
references.citation: J Physiol. 1998 Aug 1;510 ( Pt 3):829-43
references.pmid: 9660897
references.citation: J Physiol. 2002 Sep 15;543(Pt 3):795-806
references.pmid: 12231639
references.citation: Cereb Cortex. 2009 Oct;19(10):2281-9
references.pmid: 19176638
references.citation: Hear Res. 2012 May;287(1-2):43-50
references.pmid: 22726616
references.citation: Neuroscience. 1995 Oct;68(4):1105-25
references.pmid: 8544986
references.citation: J Neurosci. 2004 Jan 14;24(2):341-9
references.pmid: 14724232
references.citation: Brain Res Bull. 1997;42(1):27-37
references.pmid: 8978932
references.citation: Curr Opin Neurobiol. 2012 Aug;22(4):575-9
references.pmid: 22498715
references.citation: Cereb Cortex. 2010 Jan;20(1):13-24
references.pmid: 19447861
references.citation: J Neurosci Methods. 2001 Nov 15;112(1):29-42
references.pmid: 11640955
references.citation: Neuron. 2000 Sep;27(3):597-610
references.pmid: 11055441
references.citation: Proc R Soc Lond B Biol Sci. 1984 Jun 22;221(1225):411-36
references.pmid: 6146984
references.citation: Nat Neurosci. 2000 Sep;3(9):904-10
references.pmid: 10966621
references.citation: J Neurosci. 2002 Jul 15;22(14):6121-8
references.pmid: 12122073
references.citation: Nature. 2012 Feb 22;483(7387):47-52
references.pmid: 22367547
references.citation: Neurosci Lett. 2013 Apr 29;541:67-72
references.pmid: 23416319
references.citation: J Neurophysiol. 2007 Nov;98(5):2903-9
references.pmid: 17881481
references.citation: J Neurosci. 2011 May 4;31(18):6791-9
references.pmid: 21543609
references.citation: Neuroscience. 1999;92(2):445-57
references.pmid: 10408596