title: Myocardial performance index and aortic distensibility in patients with different left ventricle geometry in newly diagnosed essential hypertension.
abstract: BACKGROUND
  Abnormal left ventricular (LV) geometric patterns, particularly concentric LV hypertrophy, are associated with a greater risk of hypertensive complications. The aim of this study was to investigate the association between LV myocardial performance index (LVMPI) and aortic distensibility (AD) with different LV geometric patterns in patients with newly diagnosed hypertension (HT).
  
  
  METHODS
  We studied 181 patients with newly diagnosed HT (mean age 51.7 ± 5.4 years) and 39 healthy control subjects (mean age 51.2 ± 5.1 years). Echocardiographic examination was performed in all subjects. Four different geometric patterns were determined in hypertensive patients according to LV mass index (LVMI) and relative wall thickness (RWT). AD was calculated from the echocardiographically derived ascending aorta diameters and haemodynamic pressure measurements. LVMPI was calculated from the tissue Doppler-derived ejection time, isovolumic contraction and relaxation times.
  
  
  RESULTS
  The highest LVMPI and the lowest AD values were observed in concentric hypertrophy group compared with control, normal geometry, concentric remodelling and eccentric hypertrophy groups (p < 0.05, for all). LVMPI was associated with LVMI (r = 0.497, p < 0.001), RWT (r = 0.270, p < 0.001), AD (r = -0.316, p < 0.001) and E deceleration time (r = 0.171, p = 0.02) in bivariate analysis. In multiple linear regression analysis, LVMPI was independently related to LVMI (β = 0.381, p < 0.001) and AD (β = -0.263, p = 0.001).
  
  
  CONCLUSIONS
  The LVMPI was highest and AD was lowest in patients with concentric hypertrophy. The LVMPI was independently associated with LVMI and AD in hypertensive patients.
authors.affiliation: Adana Numune Training and Research Hospital, Department of Cardiology , Adana / Turkey.
authors.forename: Durmuş Yildiray
authors.initials: DY
authors.lastname: Sahіn
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Gülhan Yüksel
authors.initials: GY
authors.lastname: Kalkan
authors.forename: Ibrahіm
authors.initials: I
authors.lastname: Ozdoğru
authors.forename: Alі
authors.initials: A
authors.lastname: Kivrak
authors.forename: Gökhan
authors.initials: G
authors.lastname: Gözübüyük
authors.forename: Osman
authors.initials: O
authors.lastname: Kuloğlu
authors.forename: Zehra
authors.initials: Z
authors.lastname: Sümbül
authors.forename: Murat
authors.initials: M
authors.lastname: Cayli
mesh_terms: D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods*; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D015425:Myocardial Reperfusion