title: Magnetoencephalography reveals altered auditory information processing in youth with obsessive-compulsive disorder.
abstract: Patients with obsessive-compulsive disorder (OCD) often report sensory intolerances which may lead to significant functional impairment. This study used auditory evoked fields (AEFs) to address the question of whether neural correlates of sensory auditory information processing differ in youth with OCD compared with healthy comparison subjects (HCS). AEFs, recorded with a whole head 275-channel magnetoencephalography system, were elicited in response to binaural auditory stimuli from 10 pediatric subjects with OCD (ages 8-13, mean 11 years, 6 males) and 10 age- and gender-matched HCS. Three major neuromagnetic responses were studied: M70 (60-80 ms), M100 (90-120 ms), and M150 (130-190 ms). When compared with HCS, subjects with OCD demonstrated delayed latency of the M100 response. In subjects with OCD the amplitude of the M100 and M150 responses was significantly greater in the right hemisphere compared with the left hemisphere. Current results suggest that when compared with HCS, subjects with OCD have altered auditory information processing, evident from the delayed latency of the M100 response, which is thought to be associated with the encoding of physical stimulus characteristics. Interhemispheric asymmetry with increased M100 and M150 amplitudes over the right hemisphere compared with the left hemisphere was found in young OCD subjects. These results should be interpreted with caution due to the high variability rate of responses in both HCS and OCD subjects, as well as the possible effect of medication in OCD subjects.
authors.affiliation: Functional Brain Mapping Laboratory, Comprehensive Pediatric Epilepsy Center, Center for Pediatric Research, Walt Disney Pavilion Florida Hospital for Children, Orlando, FL 32803, USA. milena.korostenskaja@gmail.com
authors.forename: Milena
authors.initials: M
authors.lastname: Korostenskaja
authors.forename: Elana
authors.initials: E
authors.lastname: Harris
authors.forename: Cathy
authors.initials: C
authors.lastname: Giovanetti
authors.forename: Paul
authors.initials: P
authors.lastname: Horn
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wang
authors.forename: Douglas
authors.initials: D
authors.lastname: Rose
authors.forename: Hisako
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Jing
authors.initials: J
authors.lastname: Xiang
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D000704:Analysis of Variance; D001931:Brain Mapping; D002648:Child; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D019416:Head Movements; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology