title: Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva.
abstract: Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
authors.forename: Seong-Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: So Hee
authors.initials: SH
authors.lastname: Kwon
authors.forename: Seon-Hui
authors.initials: SH
authors.lastname: Park
authors.forename: Jae Kyun
authors.initials: JK
authors.lastname: Lee
authors.forename: Hea-Son
authors.initials: HS
authors.lastname: Bang
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.forename: Hak Cheol
authors.initials: HC
authors.lastname: Kwon
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
mesh_terms: D000818:Animals; D001517:Coleoptera / Q000382:microbiology*; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D056466:Histone Demethylases / Q000037:antagonists & inhibitors*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007189:Indans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007814:Larva / Q000382:microbiology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry
chemical_list: D006843:Hydrocarbons, Chlorinated; D007189:Indans; C583059:tripartin; D056466:Histone Demethylases