title: Variations in the PDCD6 gene are associated with increased uterine leiomyoma risk in the Chinese.
abstract: Programmed cell death 6 (PDCD6) participates in T cell receptor, Fas, and glucocorticoid-induced programmed cell death. To test the relationship between PDCD6 polymorphisms and uterine leiomyomas (UL) risk, we investigated the association of two SNPs (rs4957014 and rs3756712) in PDCD6 with UL risk in a case-control study of 295 unrelated premenopausal UL patients and 436 healthy postmenopausal control subjects in a population of China. Genotypes of the two SNPs were determined with the use of PCR-restriction fragment length polymorphism assay. Significantly increased UL risks were found to be associated with the T allele of rs4957014 and the T allele of rs3756712 (p=0.016, odds ratio [OR]=1.325, 95% confidence intervals [CI]=1.053-1.668 for rs4957014; p<0.0001, OR=1.898, 95% CI=1.457-2.474 for rs3756712, respectively). Increased UL risks were associated with them in different genetic models. The present study provided evidence that rs4957014 and rs3756712 are associated with UL risk, the results indicated that genetic polymorphisms in PDCD6 may contribute to the development of UL.
authors.affiliation: Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Kui
authors.initials: K
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Shi
authors.forename: Yaping
authors.initials: Y
authors.lastname: Song
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012306:Risk; D055815:Young Adult
chemical_list: D051017:Apoptosis Regulatory Proteins; D002135:Calcium-Binding Proteins; C097753:PDCD6 protein, human
references.citation: Biochem Biophys Res Commun. 2004 Oct 1;322(4):1153-65
references.pmid: 15336963
references.citation: Eur J Contracept Reprod Health Care. 2008 Sep;13(3):323-6
references.pmid: 18609347
references.citation: Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10155-60
references.pmid: 18632575
references.citation: Fertil Steril. 2009 Oct;92(4):1436-1446
references.pmid: 19019355
references.citation: FEBS Lett. 2002 Oct 9;529(2-3):183-7
references.pmid: 12372597
references.citation: Biochem Biophys Res Commun. 2009 Jan 2;378(1):145-8
references.pmid: 19013425
references.citation: Curr Opin Neurobiol. 2000 Feb;10(1):111-7
references.pmid: 10679436
references.citation: Br Med J (Clin Res Ed). 1986 Aug 9;293(6543):359-62
references.pmid: 3730804
references.citation: Mol Oncol. 2008 Apr;1(4):431-9
references.pmid: 19383317
references.citation: Biochemistry. 2004 Sep 7;43(35):11175-86
references.pmid: 15366927
references.citation: Int J Womens Health. 2011;3:231-41
references.pmid: 21892334
references.citation: J Biol Chem. 2004 Jan 2;279(1):177-87
references.pmid: 14561754
references.citation: Am J Pathol. 2003 Jul;163(1):81-9
references.pmid: 12819013
references.citation: Biochim Biophys Acta. 2002 Nov 4;1600(1-2):51-60
references.pmid: 12445459
references.citation: J Neurosci. 2006 Jan 11;26(2):542-9
references.pmid: 16407552
references.citation: Oncogene. 2002 Oct 3;21(44):6801-8
references.pmid: 12360406
references.citation: Mol Cell Biol. 2002 Jun;22(12):4094-100
references.pmid: 12024023
references.citation: J Biol Chem. 2003 Oct 3;278(40):39104-13
references.pmid: 12860994
references.citation: Cancer Sci. 2008 Nov;99(11):2193-9
references.pmid: 18957060
references.citation: Am J Public Health. 1996 Jun;86(6):858-62
references.pmid: 8659663
references.citation: J Biol Chem. 2008 Dec 12;283(50):34954-65
references.pmid: 18936101
references.citation: Br J Obstet Gynaecol. 1990 Apr;97(4):285-98
references.pmid: 2187522
references.citation: Am J Obstet Gynecol. 2003 Jan;188(1):100-7
references.pmid: 12548202
references.citation: Biochem Biophys Res Commun. 2007 Feb 16;353(3):756-63
references.pmid: 17196169
references.citation: Fertil Steril. 2003 Dec;80(6):1488-94
references.pmid: 14667888
references.citation: Bioinformatics. 2006 Aug 1;22(15):1928-9
references.pmid: 16720584
references.citation: Obstet Gynecol. 1997 Dec;90(6):967-73
references.pmid: 9397113
references.citation: J Biol Chem. 2004 Jan 16;279(3):2046-52
references.pmid: 14585841
references.citation: Biol Cell. 2006 Jan;98(1):69-77
references.pmid: 16354163
references.citation: Biochem Biophys Res Commun. 2009 Aug 14;386(1):237-41
references.pmid: 19520058
references.citation: Hum Reprod. 2001 Nov;16(11):2411-7
references.pmid: 11679530
references.citation: Sci China Life Sci. 2011 Aug;54(8):770-9
references.pmid: 21786200
references.citation: Hum Genet. 2009 Apr;125(3):257-63
references.pmid: 19132395
references.citation: Mol Biol Evol. 2001 Sep;18(9):1611-30
references.pmid: 11504843
references.citation: Science. 1996 Jan 26;271(5248):521-5
references.pmid: 8560270
references.citation: FEBS Lett. 2003 Dec 18;555(3):478-82
references.pmid: 14675759