title: Applications of ambient mass spectrometry in high-throughput screening.
abstract: The development of rapid screening and identification techniques is of great importance for drug discovery, doping control, forensic identification, food safety and quality control. Ambient mass spectrometry (AMS) allows rapid and direct analysis of various samples in open air with little sample preparation. Recently, its applications in high-throughput screening have been in rapid progress. During the past decade, various ambient ionization techniques have been developed and applied in high-throughput screening. This review discusses typical applications of AMS, including DESI (desorption electrospray ionization), DART (direct analysis in real time), EESI (extractive electrospray ionization), etc., in high-throughput screening (HTS).
authors.affiliation: Beijing National Laboratory for Molecular Science, Institute of Analytical Chemistry, Peking University, Beijing 100871, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Li
authors.forename: Bao-Sheng
authors.initials: BS
authors.lastname: Feng
authors.forename: Jian-Wang
authors.initials: JW
authors.lastname: Yang
authors.forename: Cui-Lan
authors.initials: CL
authors.lastname: Chang
authors.forename: Yu
authors.initials: Y
authors.lastname: Bai
authors.forename: Hu-Wei
authors.initials: HW
authors.lastname: Liu
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*