title: Pseudotumor cerebri in a child treated with acitretin: a rare occurrence.
abstract: Pseudotumor cerebri (PTC) is a rare neurological disorder characterized by increased intracranial pressure in absence of any intra-cranial space-occupying lesion. It is mostly due to impairment of drainage of CSF from arachnoid villi. Clinically pseudotumor cerebri presents with headache, diplopia, nausea, vomiting, papilloedema and if treatment is delayed, may lead to blindness. Females of childbearing age group, endocrinal abnormalities and ingestion of certain drugs have been reported to be associated with pseudotumor cerebri. However, it's occurrence in relation to acitretin ingestion has not been reported on pubmed database. Here we present a case where significant temporal association of acitretin intake with PTC was found in a child who was being treated with this medication for recalcitrant pustular psoriasis. The case is reported for its rarity in occurrence and associated significant morbidity including visual loss if not diagnosed and treated immediately. According to Naranjo ADR Causality scale of adverse drug reaction, the association of PTC due to acitretin in our case was probable.
authors.affiliation: Department of Dermatology, School of Tropical Medicine, Kolkata, West Bengal, India.
authors.forename: Somenath
authors.initials: S
authors.lastname: Sarkar
authors.forename: Kapildev
authors.initials: K
authors.lastname: Das
authors.forename: Soumyajit
authors.initials: S
authors.lastname: Roychoudhury
authors.forename: Arpit
authors.initials: A
authors.lastname: Shrimal
mesh_terms: D017255:Acitretin / Q000009:adverse effects*; D002648:Child; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects; D007641:Keratolytic Agents / Q000009:adverse effects*; D008297:Male; D011559:Pseudotumor Cerebri / Q000139:chemically induced*; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D007641:Keratolytic Agents; D017255:Acitretin
keywords: Acitretin; child; pseudotumor cerebri
references.citation: Arch Dis Child. 1998 May;78(5):469-73
references.pmid: 9659097
references.citation: J Dermatol. 1999 Mar;26(3):141-9
references.pmid: 10209919
references.citation: Acta Paediatr. 1995 Aug;84(8):863-6
references.pmid: 7488807
references.citation: J Neurol Sci. 2010 Mar 15;290(1-2):86-9
references.pmid: 19945715
references.citation: Pediatr Pulmonol. 1995 Jun;19(6):396-7
references.pmid: 7567222
references.citation: Br J Dermatol. 2010 May;162(5):952-63
references.pmid: 20423353
references.citation: Obstet Gynecol. 1995 Aug;86(2):318-20
references.pmid: 7617371
references.citation: Haematologica. 1996 Mar-Apr;81(2):152-4
references.pmid: 8641645
references.citation: Arch Neurol. 1988 Aug;45(8):875-7
references.pmid: 3395261
references.citation: Cardiology. 1996 Jan-Feb;87(1):90
references.pmid: 8631054
references.citation: Haematologica. 1997 Jan-Feb;82(1):106-21
references.pmid: 9107096
references.citation: Clin Pharmacol Ther. 1981 Aug;30(2):239-45
references.pmid: 7249508
references.citation: J Pediatr. 1997 Mar;130(3):478-80
references.pmid: 9063429
references.citation: Eur Arch Otorhinolaryngol. 2009 Jun;266(6):803-6
references.pmid: 19352689