title: Resveratrol suppresses microcirculatory disturbance in a rat model of severe acute pancreatitis.
abstract: The present study sought to understand the mechanisms of attenuation of severe acute pancreatitis (SAP) by resveratrol (RES). SAP was experimentally induced in rats by injection of 4% sodium taurocholate in the retrograde pancreatic duct. Three study groups were evaluated: Group I (sham-operated animals), Group II (SAP animals), and Group III (SAP animals treated with RES at 20 mg/kg/body weight, 5 min after induction of SAP). The study outcomes were histopathologic changes and alterations in biochemical markers: plasma renin activity and levels of angiotensin II, endothelin, and nitric oxide in plasma. Biochemical markers were evaluated at 3, 6, and 12 h after induction of SAP. SAP was associated with significant (p < 0.05) histopathologic changes (saponification spots in the intraperitoneal cavity, severe pancreatic edema, blood congestion, varying degrees of necrosis, etc.), as well as with elevation of biochemical markers in blood plasma. RES treatment significantly (p < 0.05) attenuated changes of both histopathologic and biochemical markers induced by SAP. In conclusion, this study provides evidence that RES treatment is a promising therapeutic approach to suppress microcirculatory disturbance in SAP.
authors.affiliation: Department of Surgery, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, 710061, People's Republic of China.
authors.forename: Huanchen
authors.initials: H
authors.lastname: Sha
authors.forename: Qingyong
authors.initials: Q
authors.lastname: Ma
authors.forename: Rajiv Kumar
authors.initials: RK
authors.lastname: Jha
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wu
authors.forename: Zhang
authors.initials: Z
authors.lastname: Qingyuan
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Ma
authors.forename: Xianhua
authors.initials: X
authors.lastname: Luo
authors.forename: Cui
authors.initials: C
authors.lastname: Liu
mesh_terms: D000208:Acute Disease; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D016232:Endothelins / Q000097:blood; D008833:Microcirculation / Q000187:drug effects*; D009569:Nitric Oxide / Q000097:blood; D010179:Pancreas / Q000098:blood supply; D010195:Pancreatitis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000097:blood / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use*; D013656:Taurocholic Acid / Q000633:toxicity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016232:Endothelins; D013267:Stilbenes; D000804:Angiotensin II; D009569:Nitric Oxide; D013656:Taurocholic Acid; D012083:Renin; D000077185:Resveratrol