title: Escherichia coli antimicrobial resistance increased faster among geriatric outpatients compared with adult outpatients in the USA, 2000-10.
abstract: OBJECTIVE
  Few studies have examined Escherichia coli antimicrobial resistance across age groups over time. The objective of this study was to compare urinary E. coli antimicrobial resistance trends among adult and geriatric outpatients from 2000 to 2010.
  
  
  METHODS
  Antimicrobial susceptibility results for E. coli urine isolates from adult (aged 16-64 years) and geriatric (aged ≥65 years) outpatients were analysed using data from The Surveillance Network Database-USA.
  
  
  RESULTS
  Susceptibility test results from adult (n = 6 412 025) and geriatric (n = 3 395 297) outpatients showed that E. coli antimicrobial resistance increased faster among geriatric outpatients for all agents studied. The greatest increases in resistance over the study time period were for ciprofloxacin (9.4% and 23.5% increases among adult and geriatric individuals, respectively), trimethoprim/sulfamethoxazole (4.3% and 10.5%) and ampicillin (2.0% and 13.6%).
  
  
  CONCLUSIONS
  Urinary E. coli antimicrobial resistance increased faster among geriatric outpatients than adult outpatients in the USA. Rising antimicrobial resistance disproportionately affects geriatric populations and presents a threat to public health.
authors.affiliation: School of Medicine and Health Sciences, Physician Assistant Program, George Washington University, 2300 Eye Street, NW, Washington, DC 20037, USA.
authors.forename: Guillermo V
authors.initials: GV
authors.lastname: Sanchez
authors.forename: Spencer J E
authors.initials: SJ
authors.lastname: Adams
authors.forename: Alexis M G
authors.initials: AM
authors.lastname: Baird
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Master
authors.forename: Richard B
authors.initials: RB
authors.lastname: Clark
authors.forename: Jose M
authors.initials: JM
authors.lastname: Bordon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010045:Outpatients; D015995:Prevalence; D014481:United States / Q000453:epidemiology; D014552:Urinary Tract Infections / Q000453:epidemiology* / Q000382:microbiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: The Surveillance Network; antibiotic resistance; elderly; surveillance; urinary tract infections