title: Central toxic keratopathy: a clinical case series.
abstract: OBJECTIVE
  To describe clinically, a case series of central toxic keratopathy (CTK), and contribute with one possible aetiology of this entity.
  
  
  METHODS
  A retrospective observational case series, which included 12 eyes diagnosed with CTK after undergoing laser refractive surgery in situ keratomileusis (LASIK).
  
  
  RESULTS
  From a total of 28 eyes that underwent LASIK in the same week, 12 develop CTK. The mean time of the diagnostic was 4 days after surgery. The resolution time had an interval between 1, 3 and 9 months, and an average of 4.6 months. The occurrence of CTK cases coincided with the change of the brand of surgical gloves, and no further cases were found after their replacement.
  
  
  CONCLUSIONS
  The CTK clinical findings are well described, but with a yet unknown origin. It seems clear that it does not require specific treatment. It is possible that there might be a relationship between a substance of the gloves and CTK. Further studies are needed to know all the details of this process.
authors.affiliation: Department of Ophthalmology Service, Hospital Clínico Universitario de Valencia, Valencia, Spain.
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Marí Cotino
authors.forename: Mayerling Mercedes
authors.initials: MM
authors.lastname: Suriano
authors.forename: Rosario Inés
authors.initials: RI
authors.lastname: De La Cruz Aguiló
authors.forename: Jorge
authors.initials: J
authors.lastname: Vila-Arteaga
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001251:Astigmatism / Q000601:surgery; D002939:Ciprofloxacin / Q000627:therapeutic use; D003318:Corneal Opacity / Q000188:drug therapy / Q000209:etiology*; D003907:Dexamethasone / Q000627:therapeutic use; D004008:Diclofenac / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D005932:Gloves, Surgical / Q000009:adverse effects*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D008297:Male; D009216:Myopia / Q000601:surgery*; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D004008:Diclofenac; D002939:Ciprofloxacin; D003907:Dexamethasone
keywords: Cornea; Inflammation; Optics and Refraction; Treatment Lasers; Wound healing