title: An efficient synthesis of fluorinated azaheterocycles by aminocyclization of alkenes.
abstract: A general and efficient approach to important fluorinated azaheterocycles has been developed by incorporating nucleophilic fluorination into alkene difunctionalization. This intramolecular aminofluorination transformation of alkenes has been achieved via the aminocyclization of reactive unsaturated N-iodoamines, which can be generated in situ from either unsaturated N-chloramines or their amine precursors in a one-pot protocol.
authors.affiliation: Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
authors.forename: Hai-Tsang
authors.initials: HT
authors.lastname: Huang
authors.forename: Tyler C
authors.initials: TC
authors.lastname: Lacy
authors.forename: Barbara
authors.initials: B
authors.lastname: Błachut
authors.forename: Gerardo X
authors.initials: GX
authors.lastname: Ortiz
authors.forename: Qiu
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000588:Amines; D001372:Aza Compounds; D006845:Hydrocarbons, Fluorinated