title: Attenuation of arsenic retention by resveratrol in lung of arsenic trioxide-exposed rats.
abstract: Arsenic trioxide (As2O3) is an important environmental toxin. In this study, the effect of resveratrol on As2O3-induced lung injury in rats is evaluated. The results showed that pre-treatment with resveratrol protected As2O3-induced lung injury by the maintenance of glutathione redox system and decrease in arsenic retention. These suggest supplement with resveratrol may alleviate lung injury in the individuals with chronic exposure to arsenic.
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Weiqian
authors.initials: W
authors.lastname: Zhang
authors.forename: Chunyu
authors.initials: C
authors.lastname: Yao
authors.forename: Ming
authors.initials: M
authors.lastname: Ge
authors.forename: Jiangdong
authors.initials: J
authors.lastname: Xue
authors.forename: Dexing
authors.initials: D
authors.lastname: Ma
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Jianyu
authors.initials: J
authors.lastname: Liu
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001151:Arsenic / Q000378:metabolism; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity; D005978:Glutathione / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010087:Oxides / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D001152:Arsenicals; D004785:Environmental Pollutants; D010087:Oxides; D017382:Reactive Oxygen Species; D013267:Stilbenes; D005978:Glutathione; D001151:Arsenic; D000077185:Resveratrol; D000077237:Arsenic Trioxide