title: Relating microarray component testing and reported food allergy and food-triggered atopic dermatitis: a real-world analysis.
abstract: BACKGROUND
  High epitope diversity has been associated with increased IgE-mediated food allergy severity.
  
  
  OBJECTIVE
  To characterize associations between results from an automated microarray system and self-reported food allergy and food-triggered atopic dermatitis (AD).
  
  
  METHODS
  Families with food allergic children were identified from a Jewish community in Lakewood, New Jersey, with immediate family members without food allergy or food-triggered AD serving as controls for the identified children. Sets of microarray components analyzed were to milk (Bos d 4, Bos d 5, Bos d 8, Bos d lactoferrin), egg (Gal d 1, Gal d 2, Gal d 3, Gal d 5), and peanut (Ara h 1, Ara h 2, Ara h 3, Ara h 6).
  
  
  RESULTS
  Seventy-three patients from 23 families were recruited. Culprit foods included milk (n = 20), egg (n = 10), and peanut (n = 6) for food allergy and milk (n = 10) and egg (n = 7) for food-triggered AD. Odds of having had a self-reported related food allergy or food-triggered AD reaction significantly increased with a higher number of detectable microarray components to that food. Ara h 1, Ara h 2, and Ara h 6 were individually associated with reported peanut allergy, and Bos d 4 was individually associated with reported milk allergy. The number of egg components significantly increased the odds of having related food-triggered AD.
  
  
  CONCLUSIONS
  High diversity of food allergen components relates well to self-reported history of food allergy and food-associated AD.
authors.affiliation: Division of Allergy and Immunology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Irene
authors.initials: I
authors.lastname: Fung
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Kim
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Spergel
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000009:adverse effects / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D010367:Arachis / Q000009:adverse effects; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D004527:Egg Proteins / Q000009:adverse effects / Q000378:metabolism*; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D046228:Microarray Analysis; D008892:Milk / Q000009:adverse effects; D055815:Young Adult
chemical_list: D000485:Allergens; D004527:Egg Proteins