title: HFE gene C282Y variant is associated with colorectal cancer in Caucasians: a meta-analysis.
abstract: The HFE gene has been suggested to play an important role in the pathogenesis of colorectal cancer. However, the results have been conflicting. In this study, we performed a meta-analysis to clarify the association of HFE gene C282Y variant with colorectal cancer. PubMed and Embase were retrieved to identify the potential literature. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. A total of eight papers including nine studies (7,588 colorectal cancer cases and 81,571 controls) for HFE gene C282Y variant were included in the meta-analysis. The result indicated that HFE gene C282Y variant was significantly associated with colorectal cancer under recessive model (OR = 2.00, 95 % CI = 1.32-3.04), with no evidence of between-study heterogeneity (I (2) = 0.2 %, p = 0.432). Further subgroup analysis by number of cases suggested the effect was significant in studies with more than 500 cases (OR = 2.51, 95 % CI = 1.58-3.98, I (2) = 0.0 %, p = 0.921), but not in studies with less than 500 cases (OR = 0.75, 95 % CI = 0.28-1.97, I (2) = 0.0 %, p = 0.622). The current meta-analysis supported the positive association of HFE gene C282Y variant with colorectal cancer. Further large-scale studies with the consideration for gene-gene/gene-environment interactions should be conducted to investigate the association.
authors.affiliation: Department of General Surgery, The Second Xiang-Ya Hospital, Central South University, ChangSha, Hunan, 410011, China. chenweidong2000@126.com
authors.forename: Weidong
authors.initials: W
authors.lastname: Chen
authors.forename: Hua
authors.initials: H
authors.lastname: Zhao
authors.forename: Tiegang
authors.initials: T
authors.lastname: Li
authors.forename: Hongliang
authors.initials: H
authors.lastname: Yao
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins
references.citation: J Natl Cancer Inst. 2005 Jun 15;97(12):917-26
references.pmid: 15956653
references.citation: Hepatology. 2010 Apr;51(4):1119-21
references.pmid: 20373367
references.citation: J Gastroenterol Hepatol. 1999 Dec;14(12):1188-91
references.pmid: 10634155
references.citation: Scand J Gastroenterol. 2013 Feb;48(2):189-95
references.pmid: 23281741
references.citation: Gastroenterology. 1997 Sep;113(3):995-9
references.pmid: 9287994
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1460-3
references.pmid: 15941956
references.citation: J Exp Clin Cancer Res. 2010 Mar 02;29:18
references.pmid: 20196837
references.citation: Hepatology. 2010 Apr;51(4):1311-8
references.pmid: 20099304
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: Ann Intern Med. 2000 Sep 5;133(5):329-37
references.pmid: 10979877
references.citation: Dis Colon Rectum. 2012 Mar;55(3):337-44
references.pmid: 22469802
references.citation: Haematologica. 1999 May;84(5):479-80
references.pmid: 10329938
references.citation: Hepatology. 2007 Oct;46(4):1071-80
references.pmid: 17828789
references.citation: J Natl Cancer Inst. 2003 Jan 15;95(2):154-9
references.pmid: 12529348
references.citation: J Natl Cancer Inst. 2003 Jun 4;95(11):829-30; author reply 830
references.pmid: 12783939
references.citation: Cancer Causes Control. 2003 Aug;14(6):541-5
references.pmid: 12948285
references.citation: Int J Cancer. 2009 Jul 1;125(1):78-83
references.pmid: 19291797
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):158-63
references.pmid: 15668490
references.citation: Carcinogenesis. 1999 Jul;20(7):1231-3
references.pmid: 10383894
references.citation: J Cancer Res Clin Oncol. 2011 Jul;137(7):1095-104
references.pmid: 21240526
references.citation: World J Gastroenterol. 2010 Feb 14;16(6):663-72
references.pmid: 20135713