title: Solid phase analytical derivatization as a sample preparation method.
abstract: Analytical derivatization (AD) is an important procedure in analysis as it improves the sensitivity, selectivity and chromatographic separation. Solid phase analytical derivatization (SPAD) combines extraction and derivatization into a single step fulfilling many aspects of a good sample preparation technique, which includes low organic solvent consumption, economical, ease of automation with any chromatographic system and applicability in a wide range of complicated matrices. In this review we have focused on wide applications of SPAD when used in combination with different sample preparation methods, such as solid phase extraction, ion exchange resins, solid phase microextraction, in-tube, microfluidic devices, and hollow fiber extraction methods.
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada. sanka@wayne.edu
authors.forename: Sanka N
authors.initials: SN
authors.lastname: Atapattu
authors.forename: Jack M
authors.initials: JM
authors.lastname: Rosenfeld
mesh_terms: D000478:Alkylation; D046210:Microfluidic Analytical Techniques; D009930:Organic Chemicals / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D052617:Solid Phase Microextraction / Q000379:methods*
chemical_list: D009930:Organic Chemicals