title: Lipid profiles of non-diabetic healthy and ischaemic heart disease patients.
abstract: OBJECTIVE
  To find any difference in the fasting lipid profile in patients with history of ischaemic heart disease (IHD) and established atherosclerotic plaques on angiography and in subjects with no known history of IHD.
  
  
  METHODS
  Observational, cross-sectional study.
  
  
  METHODS
  Immunology Department of University of Health Sciences, Lahore, from January 2007 to January 2009.
  
  
  METHODS
  In this study, 200 male subjects, between 40 and 60 years of age were recruited. Serum cholesterol and triglycerides were determined by enzymatic CHOD-PAP and GPO-PAP calorimetric method, HDL-C by accelerator selective detergent method and LDL-C by direct homogeneous enzymatic method. Serum ox-LDL contents were determined by using quantitative sandwich enzyme immuno-assay kits.
  
  
  RESULTS
  The total serum cholesterol, triglyceride and LDL-C levels were within the normal range in control and patient groups whereas HDL-C levels were significantly higher in the control group compared to the patient group (p = 0.001). A significant difference (p = 0.001) for HDL-C levels was observed between smokers and non-smokers. Serum ox-LDL levels were higher in patient group as compared to the control group but the difference was not statistically significant.
  
  
  CONCLUSIONS
  The significantly lower HDL levels in patient group with normal cholesterol, LDL and triglyceride levels may suggest low HDL-C has a greater role in IHD. Raising plasma HDL-cholesterol through weight loss, healthy diet, increased physical activity and by proper pharmacotherapy is, therefore, a legitimate therapeutic target for the optimal prevention of CHD in native population.
authors.affiliation: Department of Cardiology, Punjab Institute of Cardiology, Lahore. farhanashehzad@gmail.com
authors.forename: Farhana
authors.initials: F
authors.lastname: Shahzad
authors.forename: Shahzad
authors.initials: S
authors.lastname: Tawwab
authors.forename: Umaira
authors.initials: U
authors.lastname: Ahsan
mesh_terms: D000328:Adult; D000792:Angiography; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis*; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000000981:diagnostic imaging*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides