title: Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy.
abstract: To develop a functional nanosized transdermal drug delivery system for tumor therapy, amphiphilic hyaluronic acid (HA) based niosome was constructed combining transdermal and tumor targeting ability in one entity. HA esterified with monostearin, the conjugate labeled as HA-GMS self-assembled onto niosome surface and formed HA-niosome. The multilayer vesicle had small size (around 40 nm), good stability and desirable drug encapsulating efficacy, and well compatible with blood. It exhibited better endocytosis to mouse breast tumor cell (4T1) than the control chitosan nanoparticle, which was verified qualitatively and quantitatively. Skin permeation of HA-niosome was proven to be efficient using in vitro stratum corneum model and in vivo fluorescence observation. Histological section study confirmed the security and efficiency of transdermal permeation. The results evidence HA-niosome to be exciting and promising for tumor therapy through trandermal administration.
authors.affiliation: College of Marine Life Science, Ocean University of China, Yushan Road, Qingdao 266003, Shandong Province, China. kongming@ouc.edu.cn
authors.forename: Ming
authors.initials: M
authors.lastname: Kong
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Park
authors.forename: Chao
authors.initials: C
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: Hou
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Cheng
authors.forename: Xiguang
authors.initials: X
authors.lastname: Chen
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004337:Drug Carriers / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D004339:Drug Compounding; D004705:Endocytosis; D005989:Glycerides / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006820:Hyaluronic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D008081:Liposomes; D008297:Male; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D012867:Skin / Q000378:metabolism; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005989:Glycerides; D008081:Liposomes; D053769:Nanocapsules; D014810:Vitamin E; C048159:glyceryl monostearate; D006820:Hyaluronic Acid