title: Ternatusine A, a new pyrrole derivative with an epoxyoxepino ring from Ranunculus ternatus.
abstract: Ternatusine A (1), a novel alkaloid with an unprecedented epoxyoxepino[4,5-c] pyrrole ring, was isolated from the roots of Ranunculus ternatus Thunb. Its unusual structure, including its absolute stereochemistry, was determined using UV, IR, HRESIMS, and 1D and 2D NMR data and through comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. A possible biosynthetic pathway for ternatusine A was postulated.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China.
authors.forename: Zhilai
authors.initials: Z
authors.lastname: Zhan
authors.forename: Ziming
authors.initials: Z
authors.lastname: Feng
authors.forename: Yanan
authors.initials: Y
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Jianshuang
authors.initials: J
authors.lastname: Jiang
authors.forename: Peicheng
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification*; D031947:Ranunculus / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D011758:Pyrroles; C582941:ternatusine A