title: Vitamin D status and outcomes after renal transplantation.
abstract: Kidney transplant recipients usually have low vitamin D levels, especially in the early posttransplantation period, but the association between vitamin D status with renal outcomes is not well described in this population. Here, we studied a prospective cohort of 634 kidney recipients who underwent transplantation at a single institution between January 2005 and June 2010. In this cohort, low 25-hydroxyvitamin D concentrations 3 months after transplantation did not predict early death or graft loss but were independently associated with lower measured GFR at 12 months (P=0.001) and higher risk for interstitial fibrosis and tubular atrophy (P=0.01). In contrast, levels of calcium, phosphorus, calcitriol, parathyroid hormone, or fibroblast growth factor-23 were not consistently associated with any of the studied outcomes. In conclusion, low 25-hydroxyvitamin D concentration measured 3 months after transplantation is an independent risk factor for interstitial fibrosis progression and is associated with a lower GFR 1 year after transplantation.
authors.affiliation: INSERM U845, Centre de Recherche Croissance et Signalisation, Université Paris Descartes, Hôpital Necker Enfants Malades, 149 Rue de Sèvres, 75015 Paris, France. frank.bienaime@inserm.fr
authors.forename: Frank
authors.initials: F
authors.lastname: Bienaimé
authors.forename: Delphine
authors.initials: D
authors.lastname: Girard
authors.forename: Dany
authors.initials: D
authors.lastname: Anglicheau
authors.forename: Guillaume
authors.initials: G
authors.lastname: Canaud
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Souberbielle
authors.forename: Henri
authors.initials: H
authors.lastname: Kreis
authors.forename: Laure Hélène
authors.initials: LH
authors.lastname: Noël
authors.forename: Gérard
authors.initials: G
authors.lastname: Friedlander
authors.forename: Caroline
authors.initials: C
authors.lastname: Elie
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
authors.forename: Dominique
authors.initials: D
authors.lastname: Prié
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005355:Fibrosis; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000401:mortality; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; C104450:25-hydroxyvitamin D
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