title: Intrathecal oligoclonal IgG bands are infrequently found in neuro-Behçet's disease.
abstract: OBJECTIVE
  Oligoclonal bands (OCB) of immunoglobulins (IgG) in the cerebrospinal fluid (CSF) provides an evidence for the humoral response and have been screened in the CSF and serum of patients revealing 5 different patterns. In this study, patients with Behçet's disease (BD) are screened in a larger sample to potentially provide information about the possible role of CSF oligoclonal immunoglobulins in the diagnosis of this disease.
  
  
  METHODS
  Paired CSF and serum samples from 121 consecutive BD patients with neurological complaints (43 women and 78 men) were included in this study. Parenchymal NBD was diagnosed in 74 patients, and 22 patients had cerebral venous sinus thrombosis (CVST); of the remaining patients, 18 had primary headache disorders not directly associated with BD, and 7 had a cerebrovascular event. OCB of IgG were detected by isoelectric focusing on agarose and immunoblotting of matched serum and CSF sample pairs. Intrathecal production of IgG only is considered positive (Pattern 2 or 3).
  
  
  RESULTS
  In the whole group, only 8 patients had OCB in the CSF showing pattern 2. All these positive cases had parenchymal neuro-BD (10.8% positive and 78.4% negative in parenchymal neuro-BD group). All other groups were negative.
  
  
  CONCLUSIONS
  The rare presence of oligoclonal IgG bands in CSF can be utilized as another laboratory finding in the diagnosis of NBD.
authors.affiliation: Istanbul University Istanbul Medical Faculty, Departments of Physiology, Istanbul, Turkey. gsaruhan@istanbul.edu.tr.
authors.forename: Guher
authors.initials: G
authors.lastname: Saruhan-Direskeneli
authors.forename: S P
authors.initials: SP
authors.lastname: Yentür
authors.forename: Melike
authors.initials: M
authors.lastname: Mutlu
authors.forename: E
authors.initials: E
authors.lastname: Shugaiv
authors.forename: Nilufer
authors.initials: N
authors.lastname: Yesilot
authors.forename: M
authors.initials: M
authors.lastname: Kürtüncü
authors.forename: Gulsen
authors.initials: G
authors.lastname: Akman-Demir
mesh_terms: D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000276:immunology; D015415:Biomarkers / Q000134:cerebrospinal fluid; D015153:Blotting, Western; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000276:immunology; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid*; D011237:Predictive Value of Tests; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G; D043025:Oligoclonal Bands