title: Detection of Y Chromosome Microdeletion is Valuable in the Treatment of Patients With Nonobstructive Azoospermia and Oligoasthenoteratozoospermia: Sperm Retrieval Rate and Birth Rate.
abstract: OBJECTIVE
  We evaluated clinical characteristics, sperm retrieval rates, and birth rates in a relatively large number of infertile patients with Y chromosome microdeletions.
  
  
  METHODS
  We retrospectively reviewed clinical data from 213 patients with nonobstructive azoospermia (NOA) and 76 patients with oligoasthenoteratozoospermia (OATS) who were tested for Y chromosome microdeletion from March 2004 to June 2011.
  
  
  RESULTS
  Of the 289 patients, 110 patients presented with Y chromosome microdeletion and 179 patients presented with no microdeletion. Among the patients with Y chromosome microdeletions, 83/110 (75.4%) were NOA patients and 27/110 (24.5%) were OATS patients. After subdividing the patients with Y chromosome microdeletion, 29 had azoospermia factor (AZF)b-c microdeletion and 81 had AZFc microdeletion. The sperm retrieval rate was similar between patients with Y chromosome microdeletion and those with no microdeletion (26.6% vs. 25.6%, p=0.298) after multiple testicular sperm extraction (TESE). Excluding 53 patients who did not undergo TESE, 30 patients were analyzed. All of the 9 men with AZFb-c microdeletion had a complete absence of sperm despite multiple TESE. However, multiple TESE was successful for 9 of 21 patients with only AZFc microdeletion (p=0.041). Twenty patients with Y chromosome microdeletion gave birth.
  
  
  CONCLUSIONS
  In NOA and OATS patients, no significant difference in the sperm retrieval rate was shown between patients with Y chromosome microdeletion and those with no microdeletion. Patients with short Y chromosome microdeletion such as AZFc microdeletion have better prognoses for sperm retrieval and an increased chance of conception than do patients with larger microdeletions such as AZFb-c microdeletion.
authors.affiliation: Department of Urology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
authors.forename: Don Kyung
authors.initials: DK
authors.lastname: Choi
authors.forename: In Hyuck
authors.initials: IH
authors.lastname: Gong
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Hwang
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Oh
authors.forename: Jae Yup
authors.initials: JY
authors.lastname: Hong
keywords: Assisted reproductive techniques; Azoospermia; Male infertility; Sperm retrieval; Y chromosome
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