title: Caulerprenylols A and B, two rare antifungal prenylated para-xylenes from the green alga Caulerpa racemosa.
abstract: Two new prenylated para-xylenes, named caulerprenylols A (1) and B (2), were isolated from the green alga Caulerpa racemosa, collected from the Zhanjiang coastline, China. The structures of the two metabolites were elucidated on the basis of detailed spectroscopic analysis. This is the first report of prenylated para-xylenes from marine algae and from marine organisms as well. Moreover, caulerprenylol B (2) is also characterized by an uncommon indane ring system. In in vitro bioassays, the new compounds exhibited a broad spectrum of antifungal activity against Candida glabrata (537), Trichophyton rubrum (Cmccftla), and Cryptococcus neoformans (32609) with MIC80 values between 4 and 64 μg/mL when compared to amphotericin B (MIC80 values of 2.0, 1.0, and 4.0 μg/mL, respectively) as a positive control and showed no growth inhibition activity against the tumor cells HL60 and A549.
authors.affiliation: Center of Analysis and Testing, Nanchang University, Nanchang 330047, PR China.
authors.forename: Ai-Hong
authors.initials: AH
authors.lastname: Liu
authors.forename: Ding-Quan
authors.initials: DQ
authors.lastname: Liu
authors.forename: Tong-Jun
authors.initials: TJ
authors.lastname: Liang
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Yu
authors.forename: Mei-Tang
authors.initials: MT
authors.lastname: Feng
authors.forename: Li-Gong
authors.initials: LG
authors.lastname: Yao
authors.forename: Yi
authors.initials: Y
authors.lastname: Fang
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Feng
authors.forename: Min-Xian
authors.initials: MX
authors.lastname: Zhang
authors.forename: Shui-Chun
authors.initials: SC
authors.lastname: Mao
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D041221:Candida glabrata / Q000187:drug effects; D046068:Caulerpa / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D014249:Trichophyton / Q000187:drug effects; D014992:Xylenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D014992:Xylenes; C583900:caulerprenylol A; C583901:caulerprenylol B