title: Proton pump inhibitors and hypomagnesemia: a rare but serious complication.
abstract: Proton pump inhibitors (PPIs) promote hypomagnesemia through loss of active Mg(2+) absorption via transient receptor potential melastatin-6 and -7 (TRPM6/7). Danziger et al. confirm the association of PPIs with hypomagnesemia in patients hospitalized at a tertiary medical center. They found that patients taking PPIs, compared with those receiving histamine-2 antagonists or no acid-suppressive medications, had a decline in serum Mg(2+) after adjusting for several clinical and laboratory factors. The effect was seen only in those concomitantly receiving diuretics.
authors.affiliation: Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. mark.perazella@yale.edu
authors.forename: Mark A
authors.initials: MA
authors.lastname: Perazella
mesh_terms: D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male; D054328:Proton Pump Inhibitors / Q000009:adverse effects*
chemical_list: D054328:Proton Pump Inhibitors; D008274:Magnesium