title: Evolving Therapy of Peripheral T-cell Lymphoma: 2010 and beyond.
abstract: The peripheral T-cell lymphomas are a rare, heterogeneous group of non-Hodgkin's lymphomas which have an aggressive clinical course. Treatment approaches have traditionally been similar to those of diffuse large B-cell lymphomas, but outcomes have been inferior. Novel approaches involving agents and pathways developed from a better understanding of the biology of the diseases have led to therapeutic advances. The introduction of new agents, including antifolates, immunoconjugates, histone deacetylase inhibitors, monoclonal antibodies, nucleoside analogs, proteasome inhibitors, and signaling inhibitors have improved outcomes for patients with relapsed and refractory disease and are being incorporated into strategies for first-line therapy. Stem cell transplantation remains a potentially curative option for a subset of patients.
authors.forename: Francine
authors.initials: F
authors.lastname: Foss
keywords: T-cell leukemia; anaplastic lymphoma kinase; human T-cell lymphotropic virus-1; natural killer/T-cell lymphoma; peripheral T-cell lymphomas
references.citation: Blood. 1994 Sep 1;84(5):1361-92
references.pmid: 8068936
references.citation: Blood. 2010 Nov 4;116(18):3418-25
references.pmid: 20660290
references.citation: J Clin Oncol. 2007 Jul 1;25(19):2764-9
references.pmid: 17515574
references.citation: Hematol J. 2005;5(7):553-8
references.pmid: 15692599
references.citation: Haematologica. 2005 May;90(5):702-3
references.pmid: 15921394
references.citation: J Clin Oncol. 2008 Sep 1;26(25):4124-30
references.pmid: 18626005
references.citation: Clin Cancer Res. 2009 Apr 1;15(7):2514-22
references.pmid: 19293260
references.citation: Ann Hematol. 2009 Jul;88(7):647-52
references.pmid: 19107482
references.citation: Clin Cancer Res. 2004 Aug 15;10(16):5494-500
references.pmid: 15328188
references.citation: Biol Blood Marrow Transplant. 2008 Jan;14(1 Suppl 1):100-7
references.pmid: 18162229
references.citation: J Clin Oncol. 2010 Oct 10;28(29):4485-91
references.pmid: 20697094
references.citation: Cancer Sci. 2008 May;99(5):1016-20
references.pmid: 18294294
references.citation: Haematologica. 2007 Apr;92(4):566-7
references.pmid: 17488672
references.citation: Cancer. 2005 Dec 1;104(11):2437-41
references.pmid: 16216001
references.citation: Ann Oncol. 2010 Apr;21(4):860-863
references.pmid: 19887465
references.citation: Curr Hematol Malig Rep. 2009 Oct;4(4):236-44
references.pmid: 20425413
references.citation: Blood. 2007 Oct 1;110(7):2316-23
references.pmid: 17581918
references.citation: Br J Haematol. 2007 Feb;136(3):439-47
references.pmid: 17233846
references.citation: Blood. 2011 Feb 10;117(6):1834-9
references.pmid: 21123825
references.citation: Br J Haematol. 2010 Sep;150(5):565-73
references.pmid: 20629661
references.citation: J Clin Oncol. 2009 Nov 20;27(33):5594-600
references.pmid: 19805668
references.citation: Leuk Lymphoma. 2006 Jul;47(7):1274-82
references.pmid: 16923557
references.citation: Br J Haematol. 2009 Jul;146(2):171-9
references.pmid: 19466965
references.citation: Haematologica. 2007 Feb;92(2):271-2
references.pmid: 17296587
references.citation: J Clin Oncol. 2011 Mar 20;29(9):1182-9
references.pmid: 21245435
references.citation: Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3625-34
references.pmid: 14506150
references.citation: J Clin Oncol. 2008 May 10;26(14):2264-71
references.pmid: 18390969
references.citation: Leuk Lymphoma. 2008 Nov;49(11):2099-107
references.pmid: 19021052
references.citation: Br J Haematol. 2008 Jul;142(1):69-73
references.pmid: 18477046
references.citation: Ann Oncol. 2009 Apr;20(4):715-21
references.pmid: 19150954
references.citation: Blood. 2008 Jun 15;111(12):5496-504
references.pmid: 18385450
references.citation: J Clin Oncol. 2011 Nov 20;29(33):4410-6
references.pmid: 21990393
references.citation: Leukemia. 2005 Nov;19(11):1993-5
references.pmid: 16151464
references.citation: J Clin Oncol. 2009 Jan 1;27(1):106-13
references.pmid: 19029417
references.citation: Semin Hematol. 2006 Apr;43(2 Suppl 2):S22-6
references.pmid: 16549111
references.citation: Blood. 2008 Feb 15;111(4):1848-54
references.pmid: 18079362
references.citation: Leuk Lymphoma. 2009 Dec;50(12):1999-2004
references.pmid: 19860627
references.citation: Br J Haematol. 2007 Nov;139(3):425-8
references.pmid: 17910632
references.citation: Blood. 2011 May 12;117(19):5019-32
references.pmid: 21300984
references.citation: Cancer Chemother Pharmacol. 2007 Jun;60(1):129-34
references.pmid: 17406867
references.citation: Blood. 2004 Apr 1;103(7):2474-9
references.pmid: 14645001
references.citation: J Clin Oncol. 2007 Jul 20;25(21):3109-15
references.pmid: 17577020
references.citation: J Clin Oncol. 2006 Jun 1;24(16):2472-9
references.pmid: 16636342
references.citation: Cancer Chemother Pharmacol. 2006 Jul;58(1):35-9
references.pmid: 16308699
references.citation: J Clin Oncol. 2009 Nov 10;27(32):5410-7
references.pmid: 19826128
references.citation: Leukemia. 2010 Jan;24(1):229-32
references.pmid: 19776763
references.citation: J Invest Dermatol. 2006 Jul;126(7):1641-7
references.pmid: 16645590
references.citation: Leuk Lymphoma. 2007 Mar;48(3):521-5
references.pmid: 17454592
references.citation: J Clin Oncol. 2007 Sep 20;25(27):4293-7
references.pmid: 17709797
references.citation: Mini Rev Med Chem. 2007 Sep;7(9):976-83
references.pmid: 17897085
references.citation: Blood. 2004 Apr 15;103(8):2920-4
references.pmid: 15070664
references.citation: J Clin Oncol. 2004 Jun 1;22(11):2172-6
references.pmid: 15169805
references.citation: J Clin Oncol. 2009 Aug 20;27(24):3951-8
references.pmid: 19620487
references.citation: Intern Med J. 2007 Nov;37(11):760-6
references.pmid: 17542998