title: Utility of neut-X, neut-Y and neut-Z parameters for rapidly assessing sepsis in tumor patients.
abstract: BACKGROUND
  The Sysmex XE-5000 hematology analyzer evaluates toxic granulation and the nuclear maturity of toxic granulation neutrophils via the parameters neut-X and neut-Y. This study investigated whether neut-X and neut-Y could facilitate the auxiliary diagnosis of sepsis.
  
  
  METHODS
  Blood samples were collected from 113 patients with tumors and 130 healthy individuals to detect neut-X, neut-Y, and C-reactive protein (CRP) values. Then, we created a new parameter, neut-Z, the vector sum of neut-X and neut-Y. Furthermore, we assessed procalcitonin (PCT) concentrations in patients with sepsis and compared the values with those for neut-X, neut-Y, and neut-Z.
  
  
  RESULTS
  Neut-X, neut-Y, neut-Z, and CRP values were significantly higher in the sepsis group than in the non-sepsis and healthy groups. The ROC-AUCs for neut-X, neut-Y, neut-Z, and CRP for a diagnosis of sepsis were 0.87 (sensitivity 82%, specificity 79%), 0.87 (78 and 94%, respectively), 0.91 (82 and 88%, respectively), and 0.95 (96 and 89%, respectively), respectively. Additionally, neut-X, neut-Y, and neut-Z were correlated with CRP and PCT levels.
  
  
  CONCLUSIONS
  Neut-X and neut-Y can be used as rapid and simple auxiliary indicators in the diagnosis of sepsis in patients with tumors, and neut-Z appears to display better performance than its 2 components.
authors.affiliation: Department of Clinical Laboratory, State Key Laboratory of Oncology in South China/Cancer Center of Sun Yat-sen University, Guangzhou, Guangdong, PR China.
authors.forename: Yaoling
authors.initials: Y
authors.lastname: Luo
authors.forename: Jianhua
authors.initials: J
authors.lastname: Lin
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhang
authors.forename: Songguo
authors.initials: S
authors.lastname: Peng
authors.forename: Miaohuan
authors.initials: M
authors.lastname: Kuang
mesh_terms: D000328:Adult; D057205:Automation, Laboratory; D002097:C-Reactive Protein / Q000737:chemistry*; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000150:complications*; D009504:Neutrophils / Q000737:chemistry*; D018805:Sepsis / Q000097:blood* / Q000150:complications / Q000175:diagnosis*
chemical_list: D002097:C-Reactive Protein