title: [Adenosine triphosphate stress 99mTc-MIBI single-photon emission computed tomography in the diagnosis of ischemic heart disease].
abstract: This review is devoted to possibilities of single-photon emission computed tomography (SPECT) combined with pharmacological test with adenosine triphosphate (ATP) to detect myocardial ischemia in patients with ischemic heart disease (IHD). It contains consideration of contemporary problems and limitations inherent in use of pharmacological stress tests in radionuclide diagnostics; discussion of mechanisms of vasodilating effects of ATP in the context of modern concepts of purine receptors; detailed description of technique of pharmacological testing with ATP, as well as contraindications and possible side effects. Experience of foreign studies with the use of ATP stress testing for verification of presence of ischemia in patients with IHD is also presented.
authors.forename: I E
authors.initials: IE
authors.lastname: Karpova
authors.forename: L E
authors.initials: LE
authors.lastname: Samoĭlenko
authors.forename: G N
authors.initials: GN
authors.lastname: Soboleva
authors.forename: V B
authors.initials: VB
authors.lastname: Sergienko
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Karpov
mesh_terms: D000255:Adenosine Triphosphate / Q000009:adverse effects / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D006801:Humans; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000378:metabolism; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011983:Receptors, Purinergic / Q000145:classification / Q000378:metabolism; D015203:Reproducibility of Results; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D011983:Receptors, Purinergic; D014665:Vasodilator Agents; D000255:Adenosine Triphosphate; D017256:Technetium Tc 99m Sestamibi