title: Total oxidant, antioxidant, and paraoxonase levels in babies born to pre-eclamptic mothers.
abstract: OBJECTIVE
  The aim of this study was to investigate the oxidant-antioxidant status in babies born to pre-eclamptic mothers (BBPM).
  
  
  METHODS
  The paraoxonase (PON)-1, total antioxidant status (TAS), and total oxidant status (TOS) levels were measured in the cord blood and venous blood (7th day) of BBPM (n = 31) and babies born to normotensive mothers (n = 25).
  
  
  RESULTS
  The PON-1 and TOS levels in the cord blood and venous blood on the 7th day were not significantly different between the two groups; however, the cord blood TAS levels were higher in BBPM (P = 0.001), and the TAS levels in the venous blood were higher in the control group (P = 0.021). Furthermore, the cord blood PON-1 levels of babies born to severely pre-eclamptic mothers (n = 18) were higher than those of babies born to moderately pre-eclamptic mothers (n = 13) (P = 0.042). There were no differences in the cord blood TAS and TOS levels and venous blood PON-1, TAS, and TOS levels between babies born to severely and moderately pre-eclamptic mothers.
  
  
  CONCLUSIONS
  The increased TAS levels found in the cord blood of BBPM indicate that the fetus is protected against oxidative damage caused by increased oxidative stress in the mother. To the best of our knowledge, this is the first study in the published work investigating PON-1 levels in BBPM.
authors.affiliation: Department of Neonatology, Abant Izzet Baysal University, Medical Faculty, Bolu, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Altunhan
authors.forename: Ali
authors.initials: A
authors.lastname: Annagür
authors.forename: Sevil
authors.initials: S
authors.lastname: Kurban
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Ertuğrul
authors.forename: Murat
authors.initials: M
authors.lastname: Konak
authors.forename: Rahmi
authors.initials: R
authors.lastname: Örs
mesh_terms: D000975:Antioxidants / Q000032:analysis*; D043303:Aryldialkylphosphatase / Q000097:blood*; D002657:Child Development; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D000975:Antioxidants; D016877:Oxidants; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human