title: Preventive and therapeutic effects of ginsenoside Rb1 for neural injury during cerebral infarction in rats.
abstract: To examine the preventive and therapeutic effects of ginsenoside Rb1 for neural injury during cerebral infarction, we used a middle cerebral artery occlusion (MCAO) model in rats to investigate the effects of ginsenoside Rb1 with Edaravone as a control. Ginsenoside Rb1 was given to the rats by intragastric administration either before or after the MCAO surgery to study its preventive and therapeutic effects. Ginsenoside Rb1-treated rats had a smaller infarct volume than the positive control. Interleukin-1 (IL-1), brain-derived neurotrophic factor (BDNF), tumor necrosis factor-α (TNF-α), neurofilament (NF) and growth associated protein-43 (GAP-43) were measured to determine brain damage and the recovery of nerves. These findings suggest that ginsenoside Rb1 has neuroprotective effects in rats, and the protection efficiency is higher than Edaravone. The protective mechanism is different from Edaravone. The preventive ability of ginsenoside Rb1 is higher than its repair ability in neuroprotection in vivo.
authors.affiliation: Key Laboratory of Chronobiology, Ministry of Health (Sichuan University), Sichuan University, Chengdu, Sichuan 610041, P. R. China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Jiang
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.forename: Yun
authors.initials: Y
authors.lastname: Lu
authors.forename: Jianchun
authors.initials: J
authors.lastname: Leng
authors.forename: Quan
authors.initials: Q
authors.lastname: Xie
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D036145:Ginsenosides / Q000008:administration & dosage*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D036145:Ginsenosides; D007375:Interleukin-1; D018696:Neuroprotective Agents; C442759:ginsenoside Rb1