title: Synthesis of a series of novel chiral Lewis base catalysts and their application in promoting asymmetric hydrosilylation of β-enamino esters.
abstract: A series of novel chiral Lewis base catalysts were synthesized from L-serine and applied in the hydrosilylation of β-enamino esters, in which the optimal one promoted the reactions to afford a wide variety of β-amino esters in good yields with good enantioselectivities. It is noteworthy that several cyclic substrates were hydrosilylated under the optimal conditions to give the cyclic β-amino esters with high yields, good diastereoselectivities as well as good ee values.
authors.affiliation: Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610041 China.
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Hu
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Zhang
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: Yuan
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D058115:Lewis Bases / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D012694:Serine / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D004952:Esters; D058115:Lewis Bases; D012821:Silanes; D012694:Serine