title: Three dimensional melt-deposition of polycaprolactone/bio-derived hydroxyapatite composite into scaffold for bone repair.
abstract: In this study, three dimensional (3D) polycaprolactone/bio-derived hydroxyapatite (PCL/BHA) composite scaffolds were fabricated by using a melt-deposition system (MDS) for the applications in bone repair. PCL/BHA composites with BHA contents of 0, 10, 20, and 40% were successfully processed into 3D scaffolds by using MDS, while it was failed to fabricate PCL/BHA scaffold with BHA content of 60%. The scaffolds produced were demonstrated to possess the same structures as the predefined with highly uniform and completely interconnected pores. The compressive modulus and strength of the PCL/BHA scaffold increased from 27 to 56 MPa and from 1.9 to 4.5 MPa, respectively, as BHA content increased from 0 to 40%. The wettability of PCL/BHA composite scaffold was also improved with the increase of BHA content. Moreover, the PCL/BHA scaffolds fabricated by MDS showed satisfactory biocompatibility and were capable of being integrated with the surrounding host bone. This study shows the feasibility of fabricating 3D PCL/BHA composite scaffolds with favorable pore structures, mechanical properties, wettability and biocompatibility by using MDS and supports further research of developing novel PCL/BHA composite scaffolds with MDS for the applications in bone repair.
authors.affiliation: State Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China. jwb@sjtu.edu.cn
authors.forename: Wenbo
authors.initials: W
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Kang
authors.initials: K
authors.lastname: Sun
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry*; D019245:Compressive Strength; D004285:Dogs; D017886:Durapatite / Q000737:chemistry*; D020007:Implants, Experimental; D011091:Polyesters / Q000737:chemistry*; D012886:Skull / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D054457:Tissue Scaffolds / Q000737:chemistry*; D017155:Wettability
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; C016240:polycaprolactone; D017886:Durapatite