title: The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults.
abstract: Genome-wide association analyses have revealed common gene variations related to obesity. Variants of the fat mass and obesity-associated (FTO) gene among more than 40 genes studied were most closely associated with obesity, but the association varies among ethnicities. Moreover, the effect is significant in people of European descent as well as Asians, but less significant among people of African descent. Although the variants were also associated with type 2 diabetes and glucose homeostasis, the associations were attenuated or abolished after adjusting for adiposity. The present review considers our current understanding of the effects of the FTO variants in different ethnic groups and in adults and children.
authors.affiliation: Department of Environmental Safety, Graduate School of Science and Engineering, Yamaguchi University, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Shinozaki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Okuda
keywords: Body mass index; child; diabetes; ethnicity; fat mass and obesity-associated gene; glucose homeostasis
references.citation: Am J Clin Nutr. 2008 Oct;88(4):971-8
references.pmid: 18842783
references.citation: Obesity (Silver Spring). 2008 Sep;16(9):2187-9
references.pmid: 18551112
references.citation: Endocrinology. 2008 May;149(5):2062-71
references.pmid: 18218688
references.citation: Diabetes. 2008 Mar;57(3):791-5
references.pmid: 18162508
references.citation: Science. 2007 Nov 30;318(5855):1469-72
references.pmid: 17991826
references.citation: Int J Obes (Lond). 2013 Feb;37(2):182-7
references.pmid: 22391885
references.citation: Int J Obes (Lond). 2008 Nov;32(11):1730-5
references.pmid: 18794893
references.citation: BMC Med. 2011 Jun 08;9:71
references.pmid: 21651756
references.citation: Lancet. 2004 Jan 10;363(9403):157-63
references.pmid: 14726171
references.citation: Obes Facts. 2010 Jun;3(3):173-80
references.pmid: 20616607
references.citation: Diabetes. 2008 Jan;57(1):264-8
references.pmid: 17959933
references.citation: Diabetes. 2008 Jan;57(1):95-101
references.pmid: 17942823
references.citation: Pediatr Diabetes. 2012 Aug;13(5):384-91
references.pmid: 22141579
references.citation: Diabetes. 2008 Apr;57(4):1147-50
references.pmid: 18316358
references.citation: PLoS One. 2008 Aug 13;3(8):e2958
references.pmid: 18698412
references.citation: Biochem Biophys Res Commun. 2008 Apr 11;368(3):476-82
references.pmid: 18249188
references.citation: PLoS Genet. 2007 Jul;3(7):e115
references.pmid: 17658951
references.citation: Am J Hum Genet. 2009 Jul;85(1):106-11
references.pmid: 19559399
references.citation: N Engl J Med. 2008 Dec 11;359(24):2558-66
references.pmid: 19073975
references.citation: Eur J Endocrinol. 2011 Mar;164(3):381-8
references.pmid: 21147891
references.citation: Mamm Genome. 1999 Oct;10(10):983-6
references.pmid: 10501967
references.citation: Science. 2007 May 11;316(5826):889-94
references.pmid: 17434869
references.citation: Obesity (Silver Spring). 2008 Nov;16(11):2472-80
references.pmid: 18787525
references.citation: Ethn Dis. 2009 Winter;19(1):49-55
references.pmid: 19341163
references.citation: Diabetologia. 2008 Apr;51(4):641-7
references.pmid: 18251005
references.citation: N Engl J Med. 2010 Dec 9;363(24):2339-50
references.pmid: 21142536
references.citation: Nat Genet. 2010 Nov;42(11):937-48
references.pmid: 20935630
references.citation: J Physiol Pharmacol. 2012 Jun;63(3):241-8
references.pmid: 22791637
references.citation: J Lipid Res. 2008 Mar;49(3):607-11
references.pmid: 18048838
references.citation: Biomed Environ Sci. 2009 Dec;22(6):449-57
references.pmid: 20337217
references.citation: Diabetes. 2008 May;57(5):1419-26
references.pmid: 18346983
references.citation: BMC Med Genet. 2010 Sep 22;11:136
references.pmid: 20858286
references.citation: Hum Mol Genet. 2010 Feb 1;19(3):545-52
references.pmid: 19880856
references.citation: Diabetologia. 2007 Dec;50(12):2461-6
references.pmid: 17928989
references.citation: Int J Obes (Lond). 2012 Jan;36(1):159-63
references.pmid: 21544081
references.citation: Int J Obes (Lond). 2012 Apr;36(4):542-7
references.pmid: 22083549
references.citation: Int J Obes (Lond). 2012 Jan;36(1):61-8
references.pmid: 21986706
references.citation: Diabetes. 2009 Oct;58(10):2402-8
references.pmid: 19587359
references.citation: Obesity (Silver Spring). 2008 Aug;16(8):1969-72
references.pmid: 18535549
references.citation: BMC Med Genet. 2009 Mar 05;10:21
references.pmid: 19265514
references.citation: Diabet Med. 2011 Jun;28(6):673-80
references.pmid: 21294771
references.citation: Nature. 2009 Apr 16;458(7240):894-8
references.pmid: 19234441
references.citation: Hum Mol Genet. 2010 Jul 15;19(14):2907-16
references.pmid: 20430937
references.citation: Diabetes. 2007 Dec;56(12):3101-4
references.pmid: 17804762
references.citation: Diabetes. 2008 Oct;57(10):2851-7
references.pmid: 18599522
references.citation: Pediatr Diabetes. 2011 Aug;12(5):494-500
references.pmid: 21443588
references.citation: Hum Genet. 2009 Jun;125(5-6):615-26
references.pmid: 19322589
references.citation: PLoS One. 2010 May 20;5(5):e10521
references.pmid: 20502638
references.citation: Obesity (Silver Spring). 2010 Aug;18(8):1619-24
references.pmid: 20057365
references.citation: J Hum Genet. 2007;52(12):1031-1035
references.pmid: 17928949
references.citation: J Clin Endocrinol Metab. 2008 Apr;93(4):1501-5
references.pmid: 18252780
references.citation: Obes Rev. 2008 Mar;9 Suppl 1:53-61
references.pmid: 18307700
references.citation: Am J Clin Nutr. 2010 Feb;91(2):321-8
references.pmid: 20007308
references.citation: Ann Hum Genet. 2011 Nov;75(6):648-54
references.pmid: 21913894
references.citation: Am J Clin Nutr. 2009 Dec;90(6):1483-8
references.pmid: 19828706
references.citation: Hum Genet. 2010 Dec;128(6):589-96
references.pmid: 20811910
references.citation: J Epidemiol. 2012;22(2):130-5
references.pmid: 22327117
references.citation: PLoS One. 2008 Mar 12;3(3):e1746
references.pmid: 18335027
references.citation: Obes Facts. 2008;1(1):43-4
references.pmid: 20054161
references.citation: Ann Hum Genet. 2012 Jan;76(1):17-24
references.pmid: 22084931
references.citation: Diabetes. 2008 Aug;57(8):2226-33
references.pmid: 18469204
references.citation: Hypertens Res. 2010 Mar;33(3):214-8
references.pmid: 20075932
references.citation: Diabetologia. 2012 Apr;55(4):981-95
references.pmid: 22109280
references.citation: Endocr J. 2010;57(4):293-301
references.pmid: 20051647
references.citation: Diabetes. 2011 May;60(5):1637-44
references.pmid: 21398525
references.citation: Diabetes. 2008 Jul;57(7):1987-91
references.pmid: 18426866
references.citation: Obesity (Silver Spring). 2010 Sep;18(9):1821-6
references.pmid: 20075855
references.citation: BMC Med Genet. 2010 Jul 05;11:107
references.pmid: 20598163
references.citation: Diabetes. 2008 Aug;57(8):2245-52
references.pmid: 18487448
references.citation: World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253
references.pmid: 11234459
references.citation: J Clin Endocrinol Metab. 2009 Apr;94(4):1281-7
references.pmid: 19158205
references.citation: BMC Med Genet. 2008 Sep 17;9:85
references.pmid: 18799002
references.citation: Diabetes. 2010 Jun;59(6):1549-54
references.pmid: 20299471
references.citation: Int J Obes (Lond). 2008 Sep;32(9):1388-94
references.pmid: 18663371
references.citation: Genet Res (Camb). 2011 Dec;93(6):419-26
references.pmid: 22189607