title: Effects of antipsychotic drugs on the duration of interictal psychotic episodes in patients with epilepsy.
abstract: Treatment protocols for interictal psychosis (IIP) of patients with epilepsy have not yet been established. We aimed to clarify the effects of antipsychotic drugs (APDs) on duration of IIP episodes. We studied 393 IIP episodes in 200 patients with epilepsy in accordance with our empirical treatment protocol. The duration of all the episodes and APD treatments were reviewed. Antipsychotic drugs were used in 338 episodes and not used in 55 episodes (non-APD group). The APDs used in the treatment of IIP episodes were divided into the following three groups: first-generation APDs (FAPD, n=252), second-generation APDs (SAPD, n=44), and the combination of first- and second-generation APDs (CAPD, n=42). The non-APD group showed a significantly shorter episode duration than did the APD group (F=6.05, p=0.014). Among the 3 APD groups (FAPD, SAPD, and CAPD), there was a significant difference in duration of IIP episode (F=8.65, p=0.000). Whereas the duration of episodes was significantly longer in the CAPD group than in the other two groups, it was not significantly different between the FAPD and SAPD groups. Our findings further to clarify the nature of IIP and add further perspectives on treatment protocols for IIP.
authors.affiliation: Asai Hospital, Togane, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Hara
authors.forename: Naoto
authors.initials: N
authors.lastname: Adachi
authors.forename: Nozomi
authors.initials: N
authors.lastname: Akanuma
authors.forename: Masumi
authors.initials: M
authors.lastname: Ito
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Okazaki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kato
authors.forename: Teiichi
authors.initials: T
authors.lastname: Onuma
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004827:Epilepsy / Q000150:complications / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy*; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents