title: Dairy intakes in older girls and risk of benign breast disease in young women.
abstract: Previous investigations found high dairy intakes in girls associated with rapid height growth and excess weight gain, which had opposite relationships with benign breast disease (BBD) in young women. We use data from the longitudinal Growing Up Today Study (GUTS) to investigate whether dairy intakes, in older children/adolescents, are associated with BBD risk in young women. GUTS includes 9,039 females, ages 9-15 years in 1996, who completed questionnaires annually through 2001, then in 2003, 2005, 2007, and 2010. Dietary food frequencies (1996-2001) obtained milk, yogurt, and cheese intakes. On 2005-2010 surveys, 7,011 females (18-29 years) reported whether a health care provider ever diagnosed them with BBD (n = 250) and if confirmed by breast biopsy (n = 105). Logistic regression models estimated associations between prevalent biopsy-confirmed BBD and dairy intakes, adjusted for age and energy. Multivariable-adjusted models additionally included menarche age, childhood adiposity, adolescent alcohol consumption, and pregnancy. Further analyses stratified by family history. Age-energy-adjusted models of dairy (milk, yogurt, cheese, total dairy servings, dairy protein, dairy fat) intakes at 14 yr found no significant associations with BBD risk [milk: OR, 0.90/(serving/d); 95% confidence interval (CI), 0.76-1.05; dairy protein: OR, 0.98/(10 g/d); 95% CI, 0.82-1.17). Separate analyses of dairy intakes at 10 yr, intakes before the growth spurt, during the growth spurt, before menses-onset, and after menses-onset provided no significant associations with BBD. Multivariable adjustment, and family history stratification, did not alter the above findings. We conclude that dairy intakes by older girls have no strong relation with BBD risk in young women. Because of small number of cases, it is important to continue follow-up and re-examine later.
authors.affiliation: Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA. Catherine.Berkey@channing.harvard.edu
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Berkey
authors.forename: Walter C
authors.initials: WC
authors.lastname: Willett
authors.forename: Rulla M
authors.initials: RM
authors.lastname: Tamimi
authors.forename: Bernard
authors.initials: B
authors.lastname: Rosner
authors.forename: A Lindsay
authors.initials: AL
authors.lastname: Frazier
authors.forename: Graham A
authors.initials: GA
authors.lastname: Colditz
mesh_terms: D000293:Adolescent; D000328:Adult; D001940:Breast / Q000473:pathology*; D002648:Child; D003611:Dairy Products / Q000009:adverse effects*; D002149:Energy Intake; D005260:Female; D005348:Fibrocystic Breast Disease / Q000209:etiology* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
references.citation: J Natl Cancer Inst. 1973 Nov;51(5):1479-83
references.pmid: 4762931
references.citation: Cancer Epidemiol Biomarkers Prev. 1995 Jul-Aug;4(5):567-71
references.pmid: 7549816
references.citation: J Natl Cancer Inst. 1993 Nov 17;85(22):1819-27
references.pmid: 8230262
references.citation: Pediatr Clin North Am. 1999 Jun;46(3):607-29
references.pmid: 10384810
references.citation: Int J Obes Relat Metab Disord. 2003 Sep;27(9):1106-13
references.pmid: 12917718
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1881-7
references.pmid: 19505921
references.citation: N Engl J Med. 2004 Oct 14;351(16):1619-26
references.pmid: 15483280
references.citation: Cancer Causes Control. 2010 Nov;21(11):1875-85
references.pmid: 20658314
references.citation: Radiat Res. 2003 Dec;160(6):707-17
references.pmid: 14640793
references.citation: Prev Med. 1997 Nov-Dec;26(6):808-16
references.pmid: 9388792
references.citation: Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1159-67
references.pmid: 14652275
references.citation: Br J Nutr. 2004 Jul;92(1):159-68
references.pmid: 15230999
references.citation: Arch Pediatr Adolesc Med. 2005 Jun;159(6):543-50
references.pmid: 15939853
references.citation: Cancer. 2012 Jun 1;118(11):2796-803
references.pmid: 22083563
references.citation: Cancer. 1999 Jun 1;85(11):2400-9
references.pmid: 10357411
references.citation: Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):689-96
references.pmid: 20200427
references.citation: Pediatrics. 2010 May;125(5):e1081-7
references.pmid: 20385629
references.citation: Cancer. 2011 Apr 15;117(8):1612-20
references.pmid: 21328325
references.citation: Am J Clin Nutr. 2007 Dec;86(6):1722-9
references.pmid: 18065592
references.citation: Pediatrics. 2003 Apr;111(4 Pt 1):836-43
references.pmid: 12671121
references.citation: Int J Cancer. 2010 Jan 1;126(1):180-90
references.pmid: 19551864
references.citation: Int J Epidemiol. 1989 Dec;18(4):858-67
references.pmid: 2621022
references.citation: Nat Rev Cancer. 2005 May;5(5):388-96
references.pmid: 15864280