title: Rh(III)-catalyzed addition of alkenyl C-H bond to isocyanates and intramolecular cyclization: direct synthesis 5-ylidenepyrrol-2(5H)-ones.
abstract: The rhodium-catalyzed addition of an alkenyl C-H bond to isocyanates via sp(2) C-H bond activation followed by an intramolecular cyclization is described. This atom-economic and catalytic reaction affords a simple and straightforward access to biologically relevant 5-ylidene pyrrol-2(5H)-ones and can be carried out under mild and neutral conditions in the absence of any additives and environmentally hazardous waste production.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Shanghai 201203, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hou
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.forename: Yaxi
authors.initials: Y
authors.lastname: Yang
authors.forename: Huijin
authors.initials: H
authors.lastname: Feng
authors.forename: Yuanchao
authors.initials: Y
authors.lastname: Li
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D017953:Isocyanates / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry
chemical_list: D000475:Alkenes; D017953:Isocyanates; D011758:Pyrroles; D012238:Rhodium