title: Case of adult T-cell leukemia/lymphoma with rapid progression of pulmonary areas of ground-glass attenuation and multiple nodules.
abstract: We report a case of adult T-cell leukemia/lymphoma (ATL) with rapidly progressive pulmonary areas of ground-glass attenuation (GGA) and nodules resulting from acute transformation of chronic ATL. A 48-year-old Japanese man was admitted for progressive dyspnea. Chest computed tomography showed rapidly progressive bilateral pulmonary areas of GGA and nodules. Flow cytometry of bronchoalveolar lavage fluid and immunohistochemical examination of lung biopsy specimens revealed invasion of ATL cells. Systemic chemotherapy improved the pulmonary findings. Rapidly expanding areas of GGA and nodules are a rare manifestation of pulmonary invasion of ATL that clinicians should nevertheless keep in mind.
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka 807-8555, Japan.
authors.forename: Minako
authors.initials: M
authors.lastname: Hanaka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yatera
authors.forename: Chiyo
authors.initials: C
authors.lastname: Itoh
authors.forename: Toshinori
authors.initials: T
authors.lastname: Kawanami
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Takefumi
authors.initials: T
authors.lastname: Katsuragi
authors.forename: Shohei
authors.initials: S
authors.lastname: Shimajiri
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishimoto
authors.forename: Junichi
authors.initials: J
authors.lastname: Tsukada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
mesh_terms: D000210:Acute-Phase Reaction; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D004417:Dyspnea / Q000209:etiology; D005434:Flow Cytometry; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone