title: Co-amoxiclav-induced Stevens Johnson syndrome in a child.
abstract: Stevens-Johnson syndrome is an uncommon life threatening disease generally induced by drugs. Antibiotics, mainly sulphonamides, are the most involved drugs in Stevens-Johnson syndrome in children. Co-amoxiclav is a well tolerated antibiotic. It has never been reported to cause, lonely this syndrome in children. Herein, we report a co-amoxiclav-induced Stevens-Johnson syndrome occurring in an 18-month-old child. The diagnosis of SJS is often challenging in children and other possible diseases should be ruled out. The etiology of this syndrome is not yet fully understood. It is thought to be mediated by an immunologic mechanism. Management involves early identification, withdrawal of the culprit drug and rapid initiation of supportive therapies.
authors.affiliation: Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Tunisia.
authors.forename: Neila
authors.initials: N
authors.lastname: Fathallah
authors.forename: Zayani
authors.initials: Z
authors.lastname: Hanen
authors.forename: Raoudha
authors.initials: R
authors.lastname: Slim
authors.forename: Lobna
authors.initials: L
authors.lastname: Boussofara
authors.forename: Ghariani
authors.initials: G
authors.lastname: Najet
authors.forename: Kamel
authors.initials: K
authors.lastname: Bouraoui
authors.forename: Chaker
authors.initials: C
authors.lastname: Ben Salem
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination
keywords: Stevens Johnson syndrome; child; co-amoxiclav
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