title: A new route for the prebiotic synthesis of nucleobases and hydantoins in water/ice solutions involving the photochemistry of acetylene.
abstract: The origin of nucleobases and other heterocycles is a classic question in the chemistry of the origins of life. The construction of laboratory models for the abiotic synthesis of nitrogen heterocycles in plausible natural conditions also aids the understanding and prediction of chemical species in the Solar System. Here, we report a new explanation for the origin of hydantoins, purines, and pyrimidines in eutectic water/ice/urea solutions driven by ultraviolet irradiation (in the 185-254 nm range, UVC) of acetylene under anoxic conditions. An analysis of the products indicates the synthesis of hydantoin and 5-hydroxyhydantoin, the purines uric acid, xanthine, and guanine, and the pyrimidines uracil and cytosine. The synthesis occurred together with the photo-oxidation of bases in a complex process for which possible pathways are proposed. In conclusion, an acetylene-containing atmosphere could contribute to the origin of nucleobases in the presence of a urea/water system by an HCN-independent mechanism. The presence of ice has a dual role as a favorable medium for the synthesis of nucleobases and protection against degradation and as a source of free radicals for the synthesis of highly oxidized heterocycles. A mechanism for the origin of hydantoins and uracil from urea in plausible conditions for prebiotic chemistry is also proposed.
authors.affiliation: Centro de Astrobiología (CSIC-INTA), Ctra. Torrejón-Ajalvir km. 4, 28850 Torrejón de Ardoz, Spain. menorsc@cab.inta-csic.es
authors.forename: César
authors.initials: C
authors.lastname: Menor-Salván
authors.forename: Margarita R
authors.initials: MR
authors.lastname: Marín-Yaseli
mesh_terms: D000114:Acetylene / Q000737:chemistry* / Q000528:radiation effects; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry; D007053:Ice / Q000032:analysis; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010084:Oxidation-Reduction; D010777:Photochemistry; D056692:Prebiotics; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D014498:Uracil / Q000138:chemical synthesis; D014508:Urea / Q000737:chemistry*; D014527:Uric Acid / Q000138:chemical synthesis / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D006827:Hydantoins; D007053:Ice; D056692:Prebiotics; D011687:Purines; D011743:Pyrimidines; D014867:Water; D014527:Uric Acid; D014498:Uracil; D014508:Urea; D009584:Nitrogen; D000114:Acetylene