title: Mass spectrometry imaging for biomedical applications.
abstract: The development of technologies for mass spectrometry imaging is of substantial research interest. Mass spectrometry is potentially capable of providing highly specific information about the distribution of compounds in tissues, with high sensitivity. The in-situ analysis needed for tissue imaging requires MS to be performed under conditions different from the traditional ones, typically with intensive sample preparation and optimized for pharmaceutical applications. In this paper we critically review the current status of MS imaging with different methods of sample ionization and discuss the 3D and quantitative imaging capabilities which need further development, the importance of the multi-modal imaging, and the balance between the pursuit of high-resolution imaging and the practical application of MS imaging in biomedicine.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Jiangjiang
authors.initials: J
authors.lastname: Liu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ouyang
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000295:instrumentation*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size
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