title: Planar chiral [2.2]paracyclophane-based bis(thiourea) catalyst: application to asymmetric Henry reaction.
abstract: A bis(thiourea) organocatalyst with a planar chiral [2.2]paracyclophane backbone has been synthesized and applied to the Henry reaction. The obtained high reactivity and enantioselectivity from the reaction of aromatic aldehydes with nitroalkanes suggested the significant potential of [2.2]paracyclophane to serve as the backbone of the organocatalyst.
authors.affiliation: Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Nagoya 468-8503, Japan. skitagak@meijo-u.ac.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Kitagaki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ueda
authors.forename: Chisato
authors.initials: C
authors.lastname: Mukai
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000473:Alkanes / Q000737:chemistry; D002384:Catalysis; D004988:Ethers, Cyclic / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D008958:Models, Molecular; D009574:Nitro Compounds / Q000737:chemistry; D010880:Piperidines / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000031:analogs & derivatives*; D000097566:Cyclophanes
chemical_list: D000447:Aldehydes; D000473:Alkanes; D004988:Ethers, Cyclic; D006841:Hydrocarbons, Aromatic; D009574:Nitro Compounds; D010880:Piperidines; D013890:Thiourea; C121240:cyclophane 2; D000097566:Cyclophanes