title: Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case.
abstract: BACKGROUND
  Ependymoma associated with multiple endocrine neoplasia type 1 (MEN-1) is an extremely rare clinical entity. To the best of our knowledge, only five cases of ependymoma associated with MEN-1 have been previously described. Furthermore, there has been no case of tanycytic ependymoma of the filum terminale associated with MEN-1.
  
  
  OBJECTIVE
  The present case report illustrates a 53-year-old man with tanycytic ependymoma of the filum terminale associated with MEN-1. We review the literature on ependymoma with MEN-1 and tanycytic ependymoma of the cauda equina region and also discuss the risk of recurrence.
  
  
  METHODS
  A case report.
  
  
  METHODS
  The patient presented with complaints of nocturnal pain in the lower back, accompanied by numbness around the anus and intermittent claudication for approximately 1 year. Magnetic resonance imaging (MRI) identified an intradural-enhancing, large mass lesion at the level from Th12 to L2 vertebrae, with a cranial cystic lesion.
  
  
  RESULTS
  Open-door laminoplasty of the Th12, L1, and L2 and en bloc tumor resection with thickened filum terminale were performed. Histopathologic examination of the tumor specimens showed tanycytic ependymoma (World Health Organization Classification Grade II). At the time of the 2-year and 8-month follow-up examination, MRI did not show tumor recurrence.
  
  
  CONCLUSIONS
  This is the first reported case of this clinical entity. A careful follow-up of patients with this unusual tumor is strongly recommended.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan. funatoru3@gmail.com
authors.forename: Toru
authors.initials: T
authors.lastname: Funayama
authors.forename: Masataka
authors.initials: M
authors.lastname: Sakane
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yoshizawa
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Ochiai
mesh_terms: D002420:Cauda Equina / Q000473:pathology* / Q000601:surgery; D004806:Ependymoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007796:Laminectomy; D008159:Lumbar Vertebrae / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications* / Q000473:pathology / Q000601:surgery; D010524:Peripheral Nervous System Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery
keywords: Conus medullaris; Filum terminale; Multiple endocrine neoplasia type 1; Tanycytic ependymoma