title: Comparison of SPECT-CT results and intraoperative detection of sentinel lymph nodes in endometrial cancer.
abstract: OBJECTIVE
  The aim of the study was to compare the results of single-photon emission computed tomography-computed tomography (SPECT-CT) with those of intraoperative gamma probe detection and assess the clinical utility of SPECT-CT for sentinel lymph node biopsy in endometrial cancer.
  
  
  METHODS
  We investigated 70 patients with endometrial cancer who underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and sentinel lymph node biopsy (routine pelvic and para-aortic lymphadenectomy was additionally performed in high-risk patients). Tc-99m radiocolloid albumin was injected into the cervix and a blue dye was injected superficially into the fundus.
  
  
  RESULTS
  SPECT-CT revealed hot spots in 64 patients (91.4%). The detection rates were 97.1 and 94.3% using the combined technique and the hand-held gamma probe, respectively. In 19 cases (27.1%) 35 hot spots detected on SPECT-CT were not diagnosed as sentinel lymph nodes (SLNs) during surgery. In each patient with undetected hot spots located in the common iliac or para-aortic regions, hot SLNs were found during surgery in the obturator or external iliac region. In addition, SPECT-CT had detected 88.9% of the SLNs found during surgery. With respect to the 13 cases not detected on SPECT-CT, the hot SLNs had very low activity. Using the combined method, 95.1% of SLNs were found in typical locations (external iliac or obturator nodes). There were two metastatic nodes: one in SLN and one in nonsentinel node.
  
  
  CONCLUSIONS
  SPECT-CT yields a high SLN detection rate; however, there is significant discrepancy in comparison with intraoperative findings, which limits its clinical utility. In addition, in the majority of cases SLNs are found in typical areas, which means that they can be reliably detected using an intraoperative gamma probe.
authors.affiliation: Department of Gynecology, Medical University of Gdańsk dInstitute of Experimental Physics, University of Gdańsk, Gdańsk, Poland. sambor@gumed.edu.pl
authors.forename: Sambor
authors.initials: S
authors.lastname: Sawicki
authors.forename: Juliusz
authors.initials: J
authors.lastname: Kobierski
authors.forename: Sylwia
authors.initials: S
authors.lastname: Łapińska-Szumczyk
authors.forename: Piotr
authors.initials: P
authors.lastname: Lass
authors.forename: Wojciech
authors.initials: W
authors.lastname: Cytawa
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Bianek-Bodzak
authors.forename: Dariusz
authors.initials: D
authors.lastname: Wydra
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D005260:Female; D005720:Gamma Rays; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D021701:Sentinel Lymph Node Biopsy; D014057:Tomography, X-Ray Computed