title: Serum arginase, a biomarker of treatment efficacy in human African trypanosomiasis.
abstract: Arginase serum levels were increased in human African trypanosomiasis patients and returned to control values after treatment. Arginase hydrolyzes l-arginine to l-ornithine, which is essential for parasite growth. Moreover, l-arginine depletion impairs immune functions. Arginase may be considered as a biomarker for treatment efficacy.
authors.affiliation: Laboratoire de Parasitologie, UMR 177 IRD CIRAD, Université de Bordeaux, Bordeaux, France.
authors.forename: Romaric
authors.initials: R
authors.lastname: Nzoumbou-Boko
authors.forename: Mariette
authors.initials: M
authors.lastname: Dethoua
authors.forename: Fréderic
authors.initials: F
authors.lastname: Gabriel
authors.forename: Alain
authors.initials: A
authors.lastname: Buguet
authors.forename: Raymond
authors.initials: R
authors.lastname: Cespuglio
authors.forename: Pierrette
authors.initials: P
authors.lastname: Courtois
authors.forename: Sylvie
authors.initials: S
authors.lastname: Daulouède
authors.forename: Bernard
authors.initials: B
authors.lastname: Bouteille
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ngampo
authors.forename: Ghislain
authors.initials: G
authors.lastname: Mpandzou
authors.forename: Silla
authors.initials: S
authors.lastname: Semballa
authors.forename: Philippe
authors.initials: P
authors.lastname: Vincendeau
mesh_terms: D001119:Arginase / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D044967:Serum / Q000737:chemistry; D016896:Treatment Outcome; D014353:Trypanosomiasis, African / Q000188:drug therapy*
chemical_list: D015415:Biomarkers; D001119:Arginase
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