title: Grape seed and skin extract alleviates high-fat diet-induced renal lipotoxicity and prevents copper depletion in rat.
abstract: Obesity is a public health problem that contributes to morbidity and mortality from diabetes, heart disease, stroke, and cancers. The purpose of this investigation was to analyse the link between obesity-induced oxidative stress, renal steatosis, and kidney dysfunction, as well as the protective effect of grape seed and skin extract. Rats were fed a standard diet or a high-fat diet for 6 weeks and were either treated or not treated with grape seed and skin extract. Fat-induced oxidative stress was evaluated in the kidney with a special emphasis on transition metals. High-fat diet induced triglyceride deposition and disturbances in kidney function parameters, which are linked to an oxidative stress status and depletion of copper from the kidney. Grape seed and skin extract abrogated almost all fat-induced kidney disturbances. Grape seed and skin extract exerted potential protection against fat-induced kidney lipotoxicity and should find potential application in other kidney-related diseases.
authors.affiliation: a Laboratoire des Substances Bioactives (LSBA), Centre de Biotechnologie de Borj Cedria, BP-901, 2050 Hammam-Lif, Tunisie.
authors.forename: Kamel
authors.initials: K
authors.lastname: Charradi
authors.forename: Salem
authors.initials: S
authors.lastname: Elkahoui
authors.forename: Ines
authors.initials: I
authors.lastname: Karkouch
authors.forename: Ferid
authors.initials: F
authors.lastname: Limam
authors.forename: Ghaith
authors.initials: G
authors.lastname: Hamdaoui
authors.forename: Fethy
authors.initials: F
authors.lastname: Ben Hassine
authors.forename: Michèle Veronique
authors.initials: MV
authors.lastname: El May
authors.forename: Ahmed
authors.initials: A
authors.lastname: El May
authors.forename: Ezzedine
authors.initials: E
authors.lastname: Aouani
mesh_terms: D000818:Animals; D003300:Copper; D059305:Diet, High-Fat; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D027843:Vitis
chemical_list: D003300:Copper