title: Tetracycline and trimethoprim/sulfamethoxazole at clinical laboratory: can they help to characterize Staphylococcus aureus carrying different SCCmec types?
abstract: BACKGROUND
  Methicillin-resistant Staphylococcus aureus (MRSA) can be difficult to detect at the clinical practice.
  
  
  METHODS
  We analyzed 140 MRSA isolates from inpatients to correlate the antimicrobial susceptibility with the SCCmec types.
  
  
  RESULTS
  Type III (n = 63) isolates were more resistant to ciprofloxacin, clindamycin, cloramphenicol, erythromycin, gentamicin, and rifampin than type IV (n = 65) ones (p < 0.05). Moreover, type IV isolates were susceptible to tetracycline (100%) and trimethoprim/sulfamethoxazole (98%), while type III isolates presented resistance to them.
  
  
  CONCLUSIONS
  In regions where these SCCmec types are prevalent, the detection of specific resistant phenotypes could help to predict them, mainly when there are no technical conditions to SCCmec typing.
authors.affiliation: Laboratório de Infecção Hospitalar, Departamento de Microbiologia Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro.
authors.forename: Fernanda Sampaio
authors.initials: FS
authors.lastname: Cavalcante
authors.forename: Ricardo Pinto
authors.initials: RP
authors.lastname: Schuenck
authors.forename: Roberta Mello Ferreira
authors.initials: RM
authors.lastname: Caboclo
authors.forename: Dennis de Carvalho
authors.initials: Dde C
authors.lastname: Ferreira
authors.forename: Simone Aranha
authors.initials: SA
authors.lastname: Nouér
authors.forename: Kátia Regina Netto dos
authors.initials: KR
authors.lastname: Santos
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002876:Chromosomes, Bacterial / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005838:Genotype; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests / Q000379:methods; D010641:Phenotype; D013752:Tetracycline / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D013752:Tetracycline