title: Acute effects of second-hand smoke on complete blood count.
abstract: We assessed the acute effects of a 1-h exposure to second-hand smoke (SHS) on complete blood count (CBC) markers in a controlled simulated bar/restaurant environment. Nineteen adult never-smokers completed a 1-h .exposure to SHS at bar/restaurant levels, and a 1-h exposure to normal room air. Blood samples were collected at the baseline at 30 min during each exposure, and at 0, 0.5, 1, 2, 3, and 4 h after each exposure. The values of white blood cells (WBC) at 1 h (p = 0.010), 3 h (p = 0.040), and 4 h (p = 0.008) following SHS were significantly increased compared with the baseline values. Also, there was a positive association between the WBC and cotinine levels (r = 0.28, p = 0.007). A 1-h exposure to SHS at bar/restaurant levels significantly increased the WBC for at least 4 h following the exposure time. This effect of SHS on WBC has dose-response characteristics and should be considered to prescribing CBC.
authors.affiliation: a FAME Laboratory , Centre for Research and Technology Thessaly , Trikala , Greece .
authors.forename: Petros C
authors.initials: PC
authors.lastname: Dinas
authors.forename: Giorgos S
authors.initials: GS
authors.lastname: Metsios
authors.forename: Athanasios Z
authors.initials: AZ
authors.lastname: Jamurtas
authors.forename: Manolis N
authors.initials: MN
authors.lastname: Tzatzarakis
authors.forename: A
authors.initials: A
authors.lastname: Wallace Hayes
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Koutedakis
authors.forename: Aristidis M
authors.initials: AM
authors.lastname: Tsatsakis
authors.forename: Andreas D
authors.initials: AD
authors.lastname: Flouris
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count; D002853:Chromatography, Liquid; D003367:Cotinine / Q000097:blood*; D018592:Cross-Over Studies; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D012147:Restaurants; D013997:Time Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014028:Tobacco Smoke Pollution; D003367:Cotinine