title: Bispectral index monitoring correlates with the level of consciousness in brain injured patients.
abstract: BACKGROUND
  In general, measuring the level of consciousness in neurological patients is important. To assess the patient's mental status, the Glasgow Coma Scale (GCS) and the level of consciousness (drowsiness, stupor, and coma) have been used in clinical situations. The aim of the present study was to identify the correlation between bispectral index (BIS) and level of consciousness in brain injured patients.
  
  
  METHODS
  Eighty-nine adult patients of both sexes were included in the study. A blinded observer evaluated the mental status (GCS and level of consciousness) of a patient who is admitted in intensive care unit with brain injury, while an investigator noted the patient's BIS. The BIS was measured using a BIS monitor, Model A-3000 vista™ with Sensor Bis quatro™ (Aspect Medical Systems, Norwood, USA). A Spearman's rank correlation coefficient was used to determine if the level of consciousness correlated with the BIS.
  
  
  RESULTS
  In 89 patients, the BIS was found to be significantly correlated with the level of consciousness (r = 0.723, P < 0.01) and GCS (r = 0.646, P < 0.01). The BIS values increased with an increasing level of consciousness. Mean BIS values of coma, semicoma, stupor and drowsiness were 0.14 ± 0.23, 38.9 ± 18.0, 60.3 ± 14.5, and 73.6 ± 16.5, respectively.
  
  
  CONCLUSIONS
  In the present study, a significant correlation existed between level of consciousness and BIS. These findings suggest that BIS may be used for assessing the level of consciousness in brain injured patients. However, the scatter of BIS values for any level of consciousness limited the worth of BIS in predicting mentality except in coma patients.
authors.affiliation: Department of Anesthesiology and Pain Medicine, School of Medicine, Catholic University of Daegu, Daegu, Korea.
authors.forename: Jin Yong
authors.initials: JY
authors.lastname: Jung
authors.forename: Cheol Beom
authors.initials: CB
authors.lastname: Cho
authors.forename: Bo Mi
authors.initials: BM
authors.lastname: Min
keywords: Bispectral index; Glasgow Coma Scale; Level of consciousness
references.citation: Neuropsychol Rehabil. 2005 Jul-Sep;15(3-4):381-8
references.pmid: 16350979
references.citation: Korean J Anesthesiol. 2012 Mar;62(3):234-9
references.pmid: 22474549
references.citation: Intensive Care Med. 2001 May;27(5):853-8
references.pmid: 11430541
references.citation: Korean J Anesthesiol. 2012 Mar;62(3):230-3
references.pmid: 22474548
references.citation: Korean J Anesthesiol. 2012 Jan;62(1):13-8
references.pmid: 22323948
references.citation: Anesthesiology. 1998 Oct;89(4):980-1002
references.pmid: 9778016
references.citation: Pediatr Neurol. 2004 Jul;31(1):20-3
references.pmid: 15246487
references.citation: Crit Care Med. 2004 Dec;32(12):2403-6
references.pmid: 15599143
references.citation: Korean J Anesthesiol. 2009 Aug;57(2):185-189
references.pmid: 30625855
references.citation: Korean J Anesthesiol. 2012 Jan;62(1):98-100
references.pmid: 22323964
references.citation: J Clin Monit. 1994 Nov;10(6):392-404
references.pmid: 7836975
references.citation: Acad Emerg Med. 2003 Feb;10(2):175-9
references.pmid: 12574017
references.citation: Lancet. 1998 Dec 5;352(9143):1808-12
references.pmid: 9851380
references.citation: Korean J Anesthesiol. 2011 Mar;60(3):161-6
references.pmid: 21490816
references.citation: Intensive Care Med. 2003 Jun;29(6):933-938
references.pmid: 12734651
references.citation: Korean J Anesthesiol. 2011 Dec;61(6):511-4
references.pmid: 22220230
references.citation: Lancet. 1991 Mar 2;337(8740):535-8
references.pmid: 1671900
references.citation: Am J Respir Crit Care Med. 2002 Nov 15;166(10):1338-44
references.pmid: 12421743
references.citation: J Clin Monit Comput. 2006 Dec;20(6):399-404
references.pmid: 16964535