title: Expression of calcineurin activity after lung transplantation: a 2-year follow-up.
abstract: The objective of this pharmacodynamic study was to longitudinally assess the activity of calcineurin during the first 2 years after lung transplantation. From March 2004 to October 2008, 107 patients were prospectively enrolled and their follow-up was performed until 2009. Calcineurin activity was measured in peripheral blood mononuclear cells. We report that calcineurin activity was linked to both acute and chronic rejection. An optimal activity for calcineurin with two thresholds was defined, and we found that the risk of rejection was higher when the enzyme activity was above the upper threshold of 102 pmol/mg/min or below the lower threshold of 12 pmol/mg/min. In addition, we report that the occurrence of malignancies and viral infections was significantly higher in patients displaying very low levels of calcineurin activity. Taken together, these findings suggest that the measurement of calcineurin activity may provide useful information for the management of the prevention therapy of patients receiving lung transplantation.
authors.affiliation: Service de Biochimie Métabolomique et Protéomique, Hôpital Universitaire Necker-Enfants Malades Assistance Publique-Hôpitaux de Paris (AP-HP), France. sylvia.sanquer@gmail.com
authors.forename: Sylvia
authors.initials: S
authors.lastname: Sanquer
authors.forename: Catherine
authors.initials: C
authors.lastname: Amrein
authors.forename: Dominique
authors.initials: D
authors.lastname: Grenet
authors.forename: Romain
authors.initials: R
authors.lastname: Guillemain
authors.forename: Bruno
authors.initials: B
authors.lastname: Philippe
authors.forename: Veronique
authors.initials: V
authors.lastname: Boussaud
authors.forename: Laurence
authors.initials: L
authors.lastname: Herry
authors.forename: Celine
authors.initials: C
authors.lastname: Lena
authors.forename: Alphonsine
authors.initials: A
authors.lastname: Diouf
authors.forename: Michelle
authors.initials: M
authors.lastname: Paunet
authors.forename: Eliane M
authors.initials: EM
authors.lastname: Billaud
authors.forename: Françoise
authors.initials: F
authors.lastname: Loriaux
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Jais
authors.forename: Robert
authors.initials: R
authors.lastname: Barouki
authors.forename: Marc
authors.initials: M
authors.lastname: Stern
mesh_terms: D000328:Adult; D019703:Calcineurin / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D016040:Lung Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D019703:Calcineurin
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