title: Not all topical corticosteroids are created equal! Optimizing therapeutic outcomes through better understanding of vehicle formulations, compound selection,and methods of application.
abstract: Since the first successful topical glucocorticosteroid, compound F, was applied to human skin to treat eczematous dermatitis approximately 60 years ago, several advances have been made in the development of topical corticosteroid (TC) compounds and vehicle formulations. The ability to apply a TC and improve skin disease revolutionized dermatologic therapy and has proven to be one of the biggest advances in the history of dermatology. The potency of a TC and their vehicle formulation can vary among brand and generic TC compounds, which can sometimes confound the clinical situation as one brand or generic formulation of a TC may be well tolerated while another generic formulation induced skin irritation or allergenicity in a patient who previously encountered no difficulties.
authors.affiliation: Valley Hospital Medical Center, Las Vegas, NV, USA.
authors.forename: James Q
authors.initials: JQ
authors.lastname: Del Rosso
authors.forename: Leon H
authors.initials: LH
authors.lastname: Kircik
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical; D016568:Drugs, Generic; D006801:Humans; D007509:Irritants; D014677:Pharmaceutical Vehicles; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D000891:Anti-Infective Agents, Local; D016568:Drugs, Generic; D007509:Irritants; D014677:Pharmaceutical Vehicles