title: Signalling by the βc family of cytokines.
abstract: The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the βc family due to their receptors sharing the signalling subunit βc, regulates multiple biological processes such as native and adaptive immunity, inflammation, normal and malignant hemopoieis, and autoimmunity. Australian scientists played a major role in the discovery and biological characterisation of the βc cytokines and their recent work is revealing unique features of cytokine receptor assembly and signalling. Furthermore, specific antibodies have been generated to modulate their function. Characterisation of the structural and dynamic requirements for the activation of the βc receptor family and the molecular definition of downstream signalling pathways are providing new insights into cytokine receptor signalling as well as new therapeutic opportunities.
authors.affiliation: The Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, South Australia 5000, Australia.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Hercus
authors.forename: Urmi
authors.initials: U
authors.lastname: Dhagat
authors.forename: Winnie L T
authors.initials: WL
authors.lastname: Kan
authors.forename: Sophie E
authors.initials: SE
authors.lastname: Broughton
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Nero
authors.forename: Michelle
authors.initials: M
authors.lastname: Perugini
authors.forename: Jarrod J
authors.initials: JJ
authors.lastname: Sandow
authors.forename: Richard J
authors.initials: RJ
authors.lastname: D'Andrea
authors.forename: Paul G
authors.initials: PG
authors.lastname: Ekert
authors.forename: Timothy
authors.initials: T
authors.lastname: Hughes
authors.forename: Michael W
authors.initials: MW
authors.lastname: Parker
authors.forename: Angel F
authors.initials: AF
authors.lastname: Lopez
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000502:physiology; D016207:Cytokines / Q000502:physiology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007377:Interleukin-3 / Q000502:physiology; D015848:Interleukin-5 / Q000502:physiology; D053612:Janus Kinases / Q000378:metabolism; D016328:NF-kappa B / Q000502:physiology; D018121:Receptors, Cytokine / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D016207:Cytokines; D007377:Interleukin-3; D015848:Interleukin-5; D016328:NF-kappa B; D018121:Receptors, Cytokine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D053612:Janus Kinases
keywords: Cytokines; Inflammation; Leukaemia; Signalling; β Common receptor