title: Investigation of double bond conversion, mechanical properties, and antibacterial activity of dental resins with different alkyl chain length quaternary ammonium methacrylate monomers (QAM).
abstract: In order to endow dental resin with antibacterial activity, a series of antibacterial quaternary ammonium methacrylate monomers (QAM) with different substituted alkyl chain length (from 10 to 18) were incorporated into commonly used 2,2-bis[4-(2'-hydroxy-3'-methacryloyloxy-propoxy)-phenyl]propane (Bis-GMA)/triethyleneglycol dimethacrylate (TEGDMA) (50 wt/50 wt) dental resin as immobilized antibacterial agents. Double bond conversion (DC), flexural strength (FS) and modulus (FM), and young and mature biofilms inhibition effectiveness of prepared dental resins were studied and Bis-GMA/TEGDMA without QAM was used as reference. Results showed that there was no significant difference on DC, FS, and FM between copolymer with and without 5 wt% QAM. Substituted alkyl chain length of QAM had no influence on DC, FS, and FM of copolymer, but had influence on antibacterial activity of copolymer. Antibacterial activity of copolymer increased with increasing of substituted alkyl chain length of QAM, and the sequence followed as 5%C10 < 5%C11 ≈ 5%C12 < 5%C16 ≈ 5%C18. Copolymers containing C18 and C16 had the best inhibition effectiveness on both young biofilm and mature biofilm, copolymers containing C12 and C11 only had inhibition effectiveness on young biofilm and copolymer containing C10 had none inhibition effectiveness on neither young biofilm nor mature biofilm.
authors.affiliation: Department of Biomaterials Science, Institute of Dentistry and Biocity Turku Biomaterial Research Program, University of Turku, Turku 20520, Finland. hejin@utu.fi
authors.forename: Jingwei
authors.initials: J
authors.lastname: He
authors.forename: Eva
authors.initials: E
authors.lastname: Söderling
authors.forename: Pekka K
authors.initials: PK
authors.lastname: Vallittu
authors.forename: Lippo V J
authors.initials: LV
authors.lastname: Lassila
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D017438:Bisphenol A-Glycidyl Methacrylate / Q000737:chemistry* / Q000494:pharmacology; D003799:Dental Stress Analysis; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology; D011109:Polymethacrylic Acids / Q000737:chemistry* / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology; D012117:Resins, Synthetic / Q000737:chemistry* / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects* / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D011109:Polymethacrylic Acids; D000644:Quaternary Ammonium Compounds; D012117:Resins, Synthetic; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate