title: Feasibility of 1H-high resolution-magic angle spinning NMR spectroscopy in the analysis of viscous cosmetic and pharmaceutical formulations.
abstract: The feasibility of (1)H-High Resolution-Magic Angle Spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy for the direct analysis of viscous cosmetic and pharmaceutical formulations such as creams, gels, and pastes is presented. Three examples are described: (i) the detection of chitosan in toothpaste, (ii) the analysis of dexamethasone acetate (DMA) in a cream, and (iii) the analysis of the local anesthetics, lidocaine and prilocaine, in a gel and a cream. All active components could be directly detected in their original commercial formulations without the need for laborious sample preparation steps. In addition, the possibility for HR-MAS-based quantifications and the analysis of dynamic properties of active components in different formulations applying HR-MAS diffusion-ordered NMR spectroscopy are shown.
authors.forename: Mattia
authors.initials: M
authors.lastname: Marzorati
authors.forename: Peter
authors.initials: P
authors.lastname: Bigler
authors.forename: Michel
authors.initials: M
authors.lastname: Plattner
authors.forename: Martina
authors.initials: M
authors.lastname: Vermathen
mesh_terms: D000779:Anesthetics, Local / Q000032:analysis*; D048271:Chitosan / Q000032:analysis*; D003358:Cosmetics / Q000737:chemistry*; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000032:analysis; D005782:Gels; D008012:Lidocaine / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D011318:Prilocaine / Q000032:analysis; D063465:Skin Cream / Q000737:chemistry; D014100:Toothpastes / Q000737:chemistry*; D014783:Viscosity
chemical_list: D000779:Anesthetics, Local; D003358:Cosmetics; D005782:Gels; D014100:Toothpastes; D011318:Prilocaine; D003907:Dexamethasone; D048271:Chitosan; D008012:Lidocaine; C018038:dexamethasone acetate