title: [Ten practical issues concerning acute poisoning with carbon monoxide in pregnant women].
abstract: BACKGROUND
  The poisoning of carbon monoxide (CO) is the leading cause of death by poisoning in France. Its consequences are potentially serious to the fetus. Literature is ancient and little known.
  
  
  OBJECTIVE
  Make an inventory of knowledge about carbon monoxide poisoning during pregnancy.
  
  
  RESULTS
  The CO causes maternal then fetal tissue hypoxia primarily by binding to hemoglobin with which it has a high affinity. Its transplacental passage may cause fetal harm, predominantly in the brain. Severity seems correlated with maternal symptoms during exposure. In the absence of maternal symptoms, however, the available data are reassuring. Hyperbaric oxygen therapy may reduce the risk to the fetus.
  
  
  CONCLUSIONS
  Oxygen therapy should be offered in all cases of CO poisoning, especially if there are maternal symptoms during exposure. In addition, a fetal echography directed on the cephalic pole - even a fetal magnetic resonance imaging three weeks after exposure - should also be proposed.
authors.affiliation: Université Lille Nord de France, hôpital Jeanne de Flandre, pôle Femme-Mère-Nouveau-né, 2, avenue Oscar-Lambret, 59000 Lille cedex, France. Electronic address: elisabeth.bothuyne@orange.fr.
authors.forename: E
authors.initials: E
authors.lastname: Bothuyne-Queste
authors.affiliation: Université Lille Nord de France, hôpital Jeanne de Flandre, pôle Femme-Mère-Nouveau-né, 2, avenue Oscar-Lambret, 59000 Lille cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Joriot
authors.affiliation: Centre d'oxygénothérapie hyperbare, université Lille Nord de France, hôpital Calmette, 59000 Lille, France.
authors.forename: D
authors.initials: D
authors.lastname: Mathieu
authors.affiliation: Centre anti-poisons, université Lille Nord de France, CHRU de Lille, 59000 Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Mathieu-Nolf
authors.affiliation: Centre d'oxygénothérapie hyperbare, université Lille Nord de France, hôpital Calmette, 59000 Lille, France.
authors.forename: R
authors.initials: R
authors.lastname: Favory
authors.affiliation: Université Lille Nord de France, hôpital Jeanne de Flandre, pôle Femme-Mère-Nouveau-né, 2, avenue Oscar-Lambret, 59000 Lille cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Houfflin-Debarge
authors.affiliation: Université Lille Nord de France, hôpital Jeanne de Flandre, pôle Femme-Mère-Nouveau-né, 2, avenue Oscar-Lambret, 59000 Lille cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Vaast
authors.affiliation: Université Lille Nord de France, hôpital Jeanne de Flandre, pôle Femme-Mère-Nouveau-né, 2, avenue Oscar-Lambret, 59000 Lille cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Closset
authors.affiliation: Université Lille Nord de France, hôpital Jeanne de Flandre, pôle Femme-Mère-Nouveau-né, 2, avenue Oscar-Lambret, 59000 Lille cedex, France; EA 2694, université Lille Nord de France, 59000 Lille, France.
authors.forename: D
authors.initials: D
authors.lastname: Subtil
mesh_terms: D002249:Carbon Monoxide Poisoning / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D002263:Carboxyhemoglobin / Q000032:analysis; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000628:therapy; D005602:France; D006801:Humans; D006931:Hyperbaric Oxygenation; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D016216:Ultrasonography, Prenatal
chemical_list: D002263:Carboxyhemoglobin
keywords: Acute poisoning; Carbon monoxide; Fetal damage; Grossesse; Intoxication aiguë; Lésions fœtales; Monoxyde de carbone; Pregnancy