title: Cultivar variations in antioxidant and antihyperlipidemic properties of pomelo pulp (Citrus grandis [L.] Osbeck) in Thailand.
abstract: Pomelo (Citrus grandis L. Osbeck) is a native fruit of great economic importance in Southeast Asia. To provide experimental evidence for the antioxidant and antihyperlipidemic properties of pomelo, 6 cultivars, including Kao-Yai (KY), Thong-dee (TD), Kao-Tangkwa (KT), Kao-Numpueng (KN), Ta-Koi (TK), and Tubtim Siam (TS) were evaluated. KY had the highest phenolic content, and the strongest 1,1-diphenyl-2-pireyhydrazyl radical scavenging capacity and hydroxyl radical scavenging activity. From the high-performance liquid chromatography analysis, naringin and naringenin were the major flavonoids in the KT and TK cultivars. Six pomelo cultivars had antihyperlipidemic activities including the inhibition of pancreatic lipase and cholesterol esterase, as well as cholesterol micelle formation and bile acid binding. Hierarchical clustering analysis showed that the 6 cultivars were separated into 2 classifications. In addition, the total phenolics of the pomelo cultivars were significantly correlated with ferric reducing antioxidant power and Trolox equivalent antioxidant capacity. The results suggest that pomelo provides significant health benefits and may be used for developing functional foods.
authors.affiliation: Research Group of Herbal Medicine for Prevention and Therapeutic of Metabolic Diseases, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Kittana
authors.initials: K
authors.lastname: Mäkynen
authors.forename: Sritanaporn
authors.initials: S
authors.lastname: Jitsaardkul
authors.forename: Pansiree
authors.initials: P
authors.lastname: Tachasamran
authors.forename: Nathaporn
authors.initials: N
authors.lastname: Sakai
authors.forename: Supitcha
authors.initials: S
authors.lastname: Puranachoti
authors.forename: Natthapat
authors.initials: N
authors.lastname: Nirojsinlapachai
authors.forename: Vipaporn
authors.initials: V
authors.lastname: Chattapat
authors.forename: Natarin
authors.initials: N
authors.lastname: Caengprasath
authors.forename: Sathaporn
authors.initials: S
authors.lastname: Ngamukote
authors.forename: Sirichai
authors.initials: S
authors.lastname: Adisakwattana
mesh_terms: D000959:Antihypertensive Agents / Q000032:analysis*; D000975:Antioxidants / Q000032:analysis*; D002957:Citrus / Q000737:chemistry* / Q000145:classification; D044950:Flavanones / Q000032:analysis; D005638:Fruit / Q000737:chemistry; D010936:Plant Extracts / Q000032:analysis*; D013785:Thailand
chemical_list: D000959:Antihypertensive Agents; D000975:Antioxidants; D044950:Flavanones; D010936:Plant Extracts; C005273:naringenin; C005274:naringin