title: Haemostatic role of intermediate filaments in adhered platelets: importance of the membranous system stability.
abstract: The role of platelets in coagulation and the haemostatic process was initially suggested two centuries ago, and under appropriate physiological stimuli, these undergo abrupt morphological changes, attaching and spreading on damaged endothelium, preventing bleeding. During the adhesion process, platelet cytoskeleton reorganizes generating compartments in which actin filaments, microtubules, and associated proteins are arranged in characteristic patterns mediating crucial events, such as centralization of their organelles, secretion of granule contents, aggregation with one another to form a haemostatic plug, and retraction of these aggregates. However, the role of Intermediate filaments during the platelet adhesion process has not been explored. J. Cell. Biochem. 114: 2050-2060, 2013. © 2013 Wiley Periodicals, Inc.
authors.affiliation: Laboratorio de Hematobiología, Escuela Nacional de Medicina y Homeopatía ENMH, Instituto Politécnico Nacional IPN, Mexico City, Mexico. dcereced@prodigy.net.mx
authors.forename: Doris
authors.initials: D
authors.lastname: Cerecedo
authors.forename: Ivette
authors.initials: I
authors.lastname: Martínez-Vieyra
authors.forename: Ricardo
authors.initials: R
authors.lastname: Mondragón
authors.forename: Mónica
authors.initials: M
authors.lastname: Mondragón
authors.forename: Sirenia
authors.initials: S
authors.lastname: González
authors.forename: Iván J
authors.initials: IJ
authors.lastname: Galván
mesh_terms: D001792:Blood Platelets / Q000378:metabolism* / Q000648:ultrastructure; D015153:Blotting, Western; D003893:Desmin / Q000378:metabolism; D049029:Dystrophin-Associated Proteins / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006801:Humans; D047468:Immunoprecipitation; D007382:Intermediate Filaments / Q000378:metabolism*; D008854:Microscopy, Electron; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure; D010973:Platelet Adhesiveness / Q000235:genetics / Q000502:physiology; D051190:Plectin / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: D003893:Desmin; D049029:Dystrophin-Associated Proteins; D051190:Plectin; D014746:Vimentin
keywords: ADHERED PLATELETS; DYSTROPHIN-ASSOCIATED PROTEINS (DAPs); INTERMEDIATE FILAMENTS (IF); PLECTIN, GRANULOMERE