title: Antidepressants and rapid-cycling bipolar II disorder: dogma, definitions and deconstructing discrepant data.
abstract: It is suggested that a finding that apparently challenges current practice guidelines, namely that patients with a rapid-cycling pattern of bipolar disorder can take antidepressant monotherapy for months without increasing risk of cycling, may be parsimoniously understood by the way that the investigators defined rapid cycling and by their use of acute-phase fluoxetine monotherapy prior to randomisation to continutaion-phase therapy with fluoxetine, lithium or placebo.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Thase
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000517:prevention & control*; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use*; D008297:Male; D055502:Secondary Prevention
chemical_list: D000928:Antidepressive Agents; D018020:Lithium Compounds; D005473:Fluoxetine