title: Maternal risk factors for low birth weight for term births in a developed region in China: a hospital-based study of 55,633 pregnancies.
abstract: Low birth weight (LBW) is an important risk factor for neonatal and infant mortality and morbidity in adults.. However, no large scale study on the prevalence of LBW and related maternal risk factors in China has been published. To explore the effects of maternal factors on LBW for term birth in China, we conducted a hospital-based retrospective study of 55, 633 Chinese pregnancy cases between 2001 and 2008. Maternal sociodemographic data, history of infertility and contraceptive use were obtained. Their medical status and diseases during pre-pregnancy were examined by physical examination at the first antenatal care visit. Maternal medical status before childbirth and pregnancy outcomes, including body weight, infant gender, multiple pregnancy and congenital anomalies, were recorded. Univariate and multivariate logistic regression, and linear regression were used to investigate the relationship between maternal factors and term LBW. The general incidence of term LBW was 1.70% in the developed area of China. After preliminary analysis using the univariate model, low primary education, anemia, hypertensive disorders, placental previa, oligohydramnios and premature rupture of membrane were predicted as independent factors of term LBW in the multivariate model. Furthermore, the decrease in annual frquencies of these risk factors were major causes of gradual decline in the incidence of LBW (from 2.43% in 2001 to 1.21% in 2008). The study demonstrated that among maternal factors, primary education, anemia and hypertensive disorders could contribute to LBW for term birth even in the most developed area of China.
authors.affiliation: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China; ; Department of Reproductive Health Care, Wuxi Maternal and Child Health Hospital Affilaited to Nanjing Medical University, Wuxi, Jiangsu 214002, China.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Bian
authors.forename: Zhan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Liu
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Shoulin
authors.initials: S
authors.lastname: Wang
keywords: hypertensive disorders; low birth weight (LBW); maternal factors; multivariate regression analysis
references.citation: Environ Health Perspect. 2001 Jun;109(6):557-61
references.pmid: 11445507
references.citation: Natl Vital Stat Rep. 2003 Sep 15;52(2):1-28
references.pmid: 14518553
references.citation: Matern Child Health J. 2011 Oct;15(7):890-8
references.pmid: 20221848
references.citation: Am J Obstet Gynecol. 2008 Mar;198(3):293.e1-5
references.pmid: 18191809
references.citation: J Trop Pediatr. 2008 Jun;54(3):202-4
references.pmid: 18156642
references.citation: Pediatrics. 2003 Jun;111(6 Pt 1):1253-61
references.pmid: 12777538
references.citation: Fetal Diagn Ther. 2009;25(3):297-303
references.pmid: 19776592
references.citation: Lancet. 2009 Sep 19;374(9694):979-988
references.pmid: 19656558
references.citation: Obstet Gynecol. 2010 Aug;116(2 Pt 1):402-414
references.pmid: 20664402
references.citation: Obstet Gynecol. 2009 Nov;114(5):1121-1134
references.pmid: 20168116
references.citation: Arch Gynecol Obstet. 2004 Jan;269(2):130-3
references.pmid: 12928935
references.citation: Matern Child Health J. 2011 Jul;15(5):670-6
references.pmid: 20437196
references.citation: Hum Reprod. 2000 Aug;15(8):1856-64
references.pmid: 10920117
references.citation: BJOG. 2011 Nov;118(12):1411-21
references.pmid: 21729235
references.citation: Matern Child Health J. 2011 Oct;15(7):910-20
references.pmid: 19760166
references.citation: Eur J Obstet Gynecol Reprod Biol. 2004 Sep 10;116(1):3-15
references.pmid: 15294360
references.citation: Arch Gynecol Obstet. 2011 Jul;284(1):47-51
references.pmid: 20652281
references.citation: Am J Perinatol. 2009 Apr;26(4):279-86
references.pmid: 19021090
references.citation: Paediatr Child Health. 2006 May;11(5):283-6
references.pmid: 19030290
references.citation: BJOG. 2003 Apr;110 Suppl 20:17-23
references.pmid: 12763106
references.citation: Brain Dev. 2011 Sep;33(8):651-5
references.pmid: 21256687
references.citation: PLoS One. 2012;7(7):e40040
references.pmid: 22792210
references.citation: Am J Phys Anthropol. 1998 Apr;105(4):419-24
references.pmid: 9584886
references.citation: Eur J Obstet Gynecol Reprod Biol. 2005 Oct 1;122(2):182-6
references.pmid: 16219519
references.citation: BMC Res Notes. 2010 Jun 28;3:181
references.pmid: 20584294
references.citation: Pediatr Int. 2010 Jun;52(3):447-52
references.pmid: 19863752
references.citation: Indian J Med Res. 2009 Nov;130(5):627-33
references.pmid: 20090119
references.citation: Eur J Obstet Gynecol Reprod Biol. 2010 Feb;148(2):105-13
references.pmid: 19833428
references.citation: BMC Pregnancy Childbirth. 2010 May 19;10:22
references.pmid: 20482822
references.citation: Nestle Nutr Workshop Ser Pediatr Program. 2009;63:209-21; discussion 221-5, 259-68
references.pmid: 19346778