title: Antioxidants and diabetes.
abstract: Hyperglycemia promotes auto-oxidation of glucose to form free radicals. The generation of free radicals beyond the scavenging abilities of endogenous antioxidant defenses results in macro- and microvascular dysfunction. Antioxidants such as N-acetylcysteine, vitamin C and α-lipoic acid are effective in reducing diabetic complications, indicating that it may be beneficial either by ingestion of natural antioxidants or through dietary supplementation. However, while antioxidants are proving essential tools in the investigation of oxidant stress-related diabetic pathologies and despite the obvious potential merit of a replacement style therapy, the safety and efficacy of antioxidant supplementation in any future treatment, remains to be established.
authors.affiliation: Department of Endocrinology, Medicine, MLN Medical College, Allahabad, India.
authors.forename: Sarita
authors.initials: S
authors.lastname: Bajaj
authors.forename: Afreen
authors.initials: A
authors.lastname: Khan
keywords: Antioxidants; diabetes mellitus; free radicals
references.citation: Diabetes. 2003 Sep;52(9):2346-52
references.pmid: 12941775
references.citation: J Biochem Mol Toxicol. 2003;17(1):24-38
references.pmid: 12616644
references.citation: Physiol Rev. 2009 Jan;89(1):27-71
references.pmid: 19126754
references.citation: Ann N Y Acad Sci. 2001 Dec;947:214-22; discussion 222-3
references.pmid: 11795269
references.citation: Free Radic Biol Med. 1999 Aug;27(3-4):309-14
references.pmid: 10468203
references.citation: Heart. 2004 Jun;90(6):598-602
references.pmid: 15145850
references.citation: Diab Vasc Dis Res. 2007 Jun;4(2):89-102
references.pmid: 17654442
references.citation: J Am Coll Nutr. 2001 Oct;20(5 Suppl):363S-369S; discussion 381S-383S
references.pmid: 11603645
references.citation: Diabetes. 2011 Oct;60(10):2617-23
references.pmid: 21852676
references.citation: J Nat Prod. 2000 Jul;63(7):1035-42
references.pmid: 10924197
references.citation: Diabetes. 2002 Apr;51(4):1118-24
references.pmid: 11916934
references.citation: Bratisl Lek Listy. 2000;101(10):541-51
references.pmid: 11218944
references.citation: Nature. 2000 Apr 13;404(6779):787-90
references.pmid: 10783895
references.citation: Cardiovasc Res. 2000 Aug 18;47(3):457-64
references.pmid: 10963719
references.citation: Diabetes Care. 2004 Feb;27(2):362-6
references.pmid: 14747214
references.citation: Diabetes Care. 1995 Aug;18(8):1104-12
references.pmid: 7587845
references.citation: Nature. 2001 Dec 13;414(6865):813-20
references.pmid: 11742414
references.citation: Toxicol Appl Pharmacol. 2006 Apr 15;212(2):167-78
references.pmid: 16490224
references.citation: Exp Diabetes Res. 2012;2012:941868
references.pmid: 22007193
references.citation: J Assoc Physicians India. 2004 Oct;52:794-804
references.pmid: 15909857
references.citation: Open Cardiovasc Med J. 2010 Nov 26;4:240-56
references.pmid: 21270942
references.citation: Exp Diabetes Res. 2012;2012:481840
references.pmid: 22474423
references.citation: Cardiovasc Hematol Disord Drug Targets. 2006 Mar;6(1):1-19
references.pmid: 16724932
references.citation: Endocr Rev. 2001 Feb;22(1):36-52
references.pmid: 11159815