title: Role of NUCB2/nesfatin-1 as a possible biomarker.
abstract: Nesfatin-1, discovered by Oh-I and his coworkers in 2006, is a multi-functional peptide hormone with an approximate MW of 9.8 kDa and a half-life of 23.5 minutes. This peptide is found in three different forms, nesfatin-1, nesfatin-2 and nesfatin-3, all three of which are formed from the precursor NUCB2 by proteolytic processing. The 30-amino acid middle segment of nesfatin-1 (M30) is responsible for limiting food intake, while the exact physiological role of nesfatin-2 and nesfatin-3 is unknown. This review will focus on nesfatin-1 in relation with tissue and fluid distribution, considerations for its analysis in body fluids, and its potential as a biomarker for some diseases.
authors.affiliation: Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Firat University, School of Medicine, 23119-Elazig, TURKEY. saydin1@hotmail.com.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology*; D000080866:Nucleobindins
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins