title: Cortical reorganization in multiple sclerosis after intrathecal baclofen therapy.
abstract: Our objective was to assess the role of Intrathecal Baclofen Therapy (ITB) in the cortical reorganization in a patient affected by multiple sclerosis (MS) undergoing physical therapy. We reported a case of a woman affected by MS and severe spasticity, who performed an fMRI examination, before and after the ITB implantation. The subject showed controlateral motor cortex activation after motor task. After a month of ITB implantation, patient showed ipsilateral and controlateral motor cortex activation although with a broader extension. fMRI examination supported the hypothesis of a central influence in patients who undergo physiotherapy and therapy with ITB.
authors.affiliation: a Neurobioimaging Laboratory, IRCCS Centro Neurolesi "Bonino-Pulejo," , Messina , Italy.
authors.forename: S
authors.initials: S
authors.lastname: Guerrera
authors.forename: R
authors.initials: R
authors.lastname: Morabito
authors.forename: A
authors.initials: A
authors.lastname: Baglieri
authors.forename: F
authors.initials: F
authors.lastname: Corallo
authors.forename: R
authors.initials: R
authors.lastname: Ciurleo
authors.forename: R
authors.initials: R
authors.lastname: De Luca
authors.forename: S
authors.initials: S
authors.lastname: De Salvo
authors.forename: M A
authors.initials: MA
authors.lastname: Marino
authors.forename: L
authors.initials: L
authors.lastname: Spadaro
authors.forename: F
authors.initials: F
authors.lastname: Timpano
authors.forename: P
authors.initials: P
authors.lastname: Bramanti
authors.forename: S
authors.initials: S
authors.lastname: Marino
mesh_terms: D001418:Baclofen / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D001931:Brain Mapping; D005260:Female; D058786:GABA-B Receptor Agonists / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects; D009044:Motor Cortex / Q000187:drug effects* / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000188:drug therapy*
chemical_list: D058786:GABA-B Receptor Agonists; D001418:Baclofen