title: Sensitized pain response to bradykinin after sunburn - a human model for ongoing inflammatory pain?
authors.affiliation: Department of Anesthesiology and Operative Intensive Care, Mannheim, Heidelberg University, Theodor Kutzer Ufer 1-3, 68167 Mannheim, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Schmelz
mesh_terms: D001920:Bradykinin / Q000031:analogs & derivatives*; D004487:Edema / Q000139:chemically induced*; D006801:Humans; D010146:Pain / Q000503:physiopathology*; D017288:Pain Threshold / Q000187:drug effects*
chemical_list: D001920:Bradykinin
references.citation: Bennett GJ. What is spontaneous pain and who has it? J Pain. 2012;13:921-929.
references.citation: Dusch M, Schley M, Rukwied R, Schmelz M. Rapid flare development evoked by current frequency-dependent stimulation analyzed by full-field laser perfusion imaging. Neuroreport. 2007;18:1101-1105.
references.citation: Eisenbarth H, Rukwied R, Petersen M, Schmelz M. Sensitization to bradykinin B1 and B2 receptor activation in UV-B irradiated human skin. PAIN®. 2004;110:197-204.
references.citation: Hosogi M, Schmelz M, Miyachi Y, Ikoma A. Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch. PAIN®. 2006;126:16-23.
references.citation: Liang YF, Haake B, Reeh PW. Sustained sensitization and recruitment of rat cutaneous nociceptors by bradykinin and a novel theory of its excitatory action. J Physiol. 2001;532:229-239.
references.citation: Paterson KJ, Zambreanu L, Bennett DLH, McMahon SB. Characterisation and mechanisms of bradykinin-evoked pain in man using iontophoresis. PAIN®. 2013;154:782-792.
references.citation: Steen KH, Steen AE, Kreysel HW, Reeh PW. Inflammatory mediators potentiate pain induced by experimental tissue acidosis. PAIN®. 1996;66:163-170.