title: Multiplexed orientation and structure analysis by imaging near-edge X-ray absorption fine structure (MOSAIX) for combinatorial surface science.
abstract: Near-edge X-ray absorption fine structure (NEXAFS) spectroscopy, as a technique, offers detailed information about the bonding environment of molecules at a surface. However, because it is a synchrotron based method, beam-time is limited and users must typically prioritize and narrowly define the scopes of experiments. In this study, we demonstrate a novel method that opens up the possibility of the use of large area NEXAFS imaging to pursue combinatorial studies. To explore the capabilities of the NIST full field NEXAFS microscope available at the National Synchrotron Light Source as a high throughput imaging instrument, we collected NEXAFS images from a sample array consisting of 144 different elements with a periodic sequence of different surface modifications. NEXAFS images collected from this model system illustrate how hyperspectral NEXAFS data can be used for parallel analysis of large numbers of samples either directly from the overall image or by extracting spectra from regions of interest.
authors.affiliation: Max Planck Institute for Polymer Research, Mainz, Germany.
authors.forename: Joe E
authors.initials: JE
authors.lastname: Baio
authors.forename: Cherno
authors.initials: C
authors.lastname: Jaye
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Fischer
authors.forename: Tobias
authors.initials: T
authors.lastname: Weidner
mesh_terms: D005227:Fatty Acids / Q000032:analysis*; D005233:Fatty Alcohols / Q000032:analysis*; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000032:analysis*; D013499:Surface Properties; D056928:X-Ray Absorption Spectroscopy
chemical_list: C505222:11-mercaptoundecanoic acid; C521238:11-mercaptoundecanol; D005227:Fatty Acids; D005233:Fatty Alcohols; D013438:Sulfhydryl Compounds
references.citation: Nat Mater. 2004 May;3(5):298-301
references.pmid: 15064757
references.citation: Biopolymers. 2010;94(1):78-94
references.pmid: 20091881
references.citation: Chem Rev. 2012 Aug 8;112(8):4391-420
references.pmid: 22616565
references.citation: Comb Chem High Throughput Screen. 2007 Jan;10(1):71-82
references.pmid: 17266518
references.citation: J Electron Spectros Relat Phenomena. 2009 May 1;172(1-3):2-8
references.pmid: 20161353
references.citation: Langmuir. 2004 Mar 30;20(7):2746-52
references.pmid: 15835147
references.citation: Chem Soc Rev. 2012 Jan 21;41(2):738-81
references.pmid: 21938290
references.citation: J Am Chem Soc. 2007 Dec 19;129(50):15416-7
references.pmid: 18041835
references.citation: Rev Sci Instrum. 2009 Jul;80(7):073707
references.pmid: 19655956
references.citation: Adv Mater. 2011 Dec 1;23(45):5404-8
references.pmid: 22009688