title: In vitro antioxidant capacity and anti-inflammatory activity of seven common oats.
abstract: Oats are gaining increasing scientific and public interest for their purported antioxidant-associated health benefits. Most reported studies focused on specific oat extracts or particular oat components, such as β-glucans, tocols (vitamin E), or avenanthramides. Studies on whole oats with respect to antioxidant and anti-inflammatory activities are still lacking. Here the antioxidant and anti-inflammatory activities from whole oat groats of seven common varieties were evaluated. All oat varieties had very similar oxygen radical absorption capacity compared with other whole grains. In an anti-inflammatory assay, oat variety CDC Dancer inhibited tumor necrosis factor-α induced nuclear factor-kappa B activation by 27.5% at 2 mg/ml, whereas variety Deiter showed 13.7% inhibition at a comparable dose. Avenanthramide levels did not correlate with the observed antioxidant and anti-inflammatory activities. Further investigations are needed to pinpoint the specific antioxidant and anti-inflammatory compounds, and potential synergistic and/or matrix effects that may help explain the mechanisms of oat's anti-inflammatory actions.
authors.affiliation: PepsiCo R&D Nutrition, 617 W. Main Street, Barrington, IL 60010, USA. yifang.chu@pepsico.com
authors.forename: Yi-Fang
authors.initials: YF
authors.lastname: Chu
authors.forename: Mitchell L
authors.initials: ML
authors.lastname: Wise
authors.forename: Apeksha A
authors.initials: AA
authors.lastname: Gulvady
authors.forename: Tony
authors.initials: T
authors.lastname: Chang
authors.forename: David F
authors.initials: DF
authors.lastname: Kendra
authors.forename: B
authors.initials: B
authors.lastname: Jan-Willem van Klinken
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Shi
authors.forename: Marianne
authors.initials: M
authors.lastname: O'Shea
mesh_terms: D000893:Anti-Inflammatory Agents / Q000032:analysis* / Q000494:pharmacology; D000975:Antioxidants / Q000032:analysis* / Q000494:pharmacology; D018554:Avena / Q000737:chemistry* / Q000145:classification; D002470:Cell Survival / Q000187:drug effects; D057809:HEK293 Cells; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000276:immunology; D010636:Phenols / Q000032:analysis* / Q000494:pharmacology; D010936:Plant Extracts / Q000032:analysis* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016328:NF-kappa B; D010636:Phenols; D010936:Plant Extracts