title: Cullins getting undressed by the protein exchange factor Cand1.
abstract: Cullin-RING ubiquitin ligase complexes (CRLs) rely on a vast array of adaptor proteins to recognize their substrates. Pierce et al. and related papers from Zemla et al. and Wu et al. in Nature Communications show that Cand1 promotes exchange of adaptor proteins to regulate the CRL repertoire.
authors.affiliation: Institute of Biochemistry 2 and Buchmann Institute for Molecular Life Sciences, Goethe University School of Medicine, Frankfurt 60590, Germany.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Olma
authors.forename: Ivan
authors.initials: I
authors.lastname: Dikic