title: Towards robust deconvolution of low-dose perfusion CT: sparse perfusion deconvolution using online dictionary learning.
abstract: Computed tomography perfusion (CTP) is an important functional imaging modality in the evaluation of cerebrovascular diseases, particularly in acute stroke and vasospasm. However, the post-processed parametric maps of blood flow tend to be noisy, especially in low-dose CTP, due to the noisy contrast enhancement profile and the oscillatory nature of the results generated by the current computational methods. In this paper, we propose a robust sparse perfusion deconvolution method (SPD) to estimate cerebral blood flow in CTP performed at low radiation dose. We first build a dictionary from high-dose perfusion maps using online dictionary learning and then perform deconvolution-based hemodynamic parameters estimation on the low-dose CTP data. Our method is validated on clinical data of patients with normal and pathological CBF maps. The results show that we achieve superior performance than existing methods, and potentially improve the differentiation between normal and ischemic tissue in the brain.
authors.affiliation: Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY, USA. rf294@cornell.edu
authors.forename: Ruogu
authors.initials: R
authors.lastname: Fang
authors.forename: Tsuhan
authors.initials: T
authors.lastname: Chen
authors.forename: Pina C
authors.initials: PC
authors.lastname: Sanelli
mesh_terms: D001185:Artificial Intelligence; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016208:Databases, Factual; D004018:Dictionaries, Medical as Topic; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D009862:Online Systems; D010363:Pattern Recognition, Automated / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods; D011829:Radiation Dosage; D011835:Radiation Protection; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
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