title: Abdominal aortic disease caused by penetrating atherosclerotic ulcers.
abstract: OBJECTIVE
  Penetrating atherosclerotic ulcer (PAU) of the aorta is defined as an atherosclerotic lesion with ulceration of the aortic intima and media and rupture of the internal elastic lamina. PAU induced aortic dissection, aortic rupture, and secular aortic aneurysm and typically occurs in elderly hypertensive patients with severe atherosclerosis. Although it has been reported that atherosclerosis similarly occurs in the abdominal aorta, its natural history and treatment are still unclear. This study investigated the clinical features, natural history, and treatment of PAU of the abdominal aorta.
  
  
  METHODS
  Between April 2006 and March 2009, 4 diagnoses of PAU in the abdominal aorta were made by computed tomography (CT) and magnetic resonance imaging (MRI). These 4 cases were analyzed along with 61 previously reported cases from the literature with diagnoses of PAU in the abdominal aorta, aortic rupture, and isolated abdominal aortic dissection over the past 15 years, giving a total of 65 cases.
  
  
  RESULTS
  The patients were men with an average age of 63.5 years. All 4 had hypertension, and 2 had concomitant coronary artery disease. Two patients were asymptomatic, and the other 2 were symptomatic and transmural rupture had occurred. All diagnoses were made by CT and MRI. All 4 patients underwent open surgery with a knitted Dacron graft, with no postoperative deaths. In the literature, 53% of cases were symptomatic, including pain (40%, n = 26), shock (4.6%, n = 3), and lower limb embolism (9.2%, n = 6). The remaining 40% of cases were asymptomatic (n = 26). Six patients were treated medically, while 58 patients underwent surgery, with 2 postoperative deaths.
  
  
  CONCLUSIONS
  We suggest that surgical treatment (open surgery or endovascular stent grafting) should be performed to prevent an aortic catastrophe such as intramural hematoma, dissection, or rupture. (English translation of Jpn J Vasc Surg 2010; 19: 723-730.).
authors.affiliation: Department of Cardiovascular Surgery, Hitachi General Hospital, Hitachi, Ibaraki, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Sato
authors.forename: Akito
authors.initials: A
authors.lastname: Imai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Akinobu
authors.initials: A
authors.lastname: Sasaki
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Jikuya
keywords: aortic rupture; isolated aortic dissection; penetrating atherosclerotic ulcer; saccular aortic aneurysm
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