title: Generalized lymphadenopathy in infancy; a case report.
abstract: BACKGROUND
  Rosai-Dorfman disease (RDD) is a rare disease of histiocytic cells, a cause of benign cervical lymphadenopathy (LAP) and massive generalized lymph node enlargement in children and adults. There are also some reports on involvement of other human body organs with or without LAP.
  
  
  METHODS
  A 7-month-old infant with chief complaint of generalized massive LAP was referred to our center. RDD was diagnosed according to clinical manifestations and confirmed through histopathologic and immunoreactivity study on the obtained sample by cervical lymph node biopsy.
  
  
  CONCLUSIONS
  RDD is not a malignant illness and lymph node enlargement most often decreases in its size happens without special treatment.
authors.affiliation: Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mamishi
authors.initials: M
authors.lastname: Setareh
authors.forename: Movahedi
authors.initials: M
authors.lastname: Zahra
authors.forename: Mohammadzadeh
authors.initials: M
authors.lastname: Vahid
authors.forename: Sabouni
authors.initials: S
authors.lastname: Farah
keywords: Generalized Lymphadenopathy; Histiocytosis; Infant; Rosai-Dorfman Disease
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