title: Consensus paper: current views on the role of cerebellar interpositus nucleus in movement control and emotion.
abstract: In the present paper, we examine the role of the cerebellar interpositus nucleus (IN) in motor and non-motor domains. Recent findings are considered, and we share the following conclusions: IN as part of the olivo-cortico-nuclear microcircuit is involved in providing powerful timing signals important in coordinating limb movements; IN could participate in the timing and performance of ongoing conditioned responses rather than the generation and/or initiation of such responses; IN is involved in the control of reflexive and voluntary movements in a task- and effector system-dependent fashion, including hand movements and associated upper limb adjustments, for quick effective actions; IN develops internal models for dynamic interactions of the motor system with the external environment for anticipatory control of movement; and IN plays a significant role in the modulation of autonomic and emotional functions.
authors.affiliation: Department of Bio-Medical Sciences, Section of Physiology, University of Catania, Viale Andrea Doria 6, 95125, Catania, Italy. perciava@unict.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Perciavalle
authors.forename: Richard
authors.initials: R
authors.lastname: Apps
authors.forename: Vlastislav
authors.initials: V
authors.lastname: Bracha
authors.forename: José M
authors.initials: JM
authors.lastname: Delgado-García
authors.forename: Alan R
authors.initials: AR
authors.lastname: Gibson
authors.forename: Maria
authors.initials: M
authors.lastname: Leggio
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Carrel
authors.forename: Nadia
authors.initials: N
authors.lastname: Cerminara
authors.forename: Marinella
authors.initials: M
authors.lastname: Coco
authors.forename: Agnès
authors.initials: A
authors.lastname: Gruart
authors.forename: Raudel
authors.initials: R
authors.lastname: Sánchez-Campusano
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002529:Cerebellar Nuclei / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D006801:Humans; D009068:Movement / Q000502:physiology*
references.citation: J Comp Neurol. 1993 Apr 1;330(1):130-46
references.pmid: 8468400
references.citation: Science. 1962 May 18;136(3516):650-2
references.pmid: 13908977
references.citation: J Neurol Neurosurg Psychiatry. 2000 Jul;69(1):102-6
references.pmid: 10864613
references.citation: J Neurophysiol. 1997 Aug;78(2):939-59
references.pmid: 9307126
references.citation: Neurosci Lett. 1988 Dec 19;95(1-3):97-101
references.pmid: 2465513
references.citation: Exp Brain Res. 1999 May;126(1):77-92
references.pmid: 10333009
references.citation: J Neurophysiol. 1985 Jul;54(1):40-60
references.pmid: 4031981
references.citation: J Neurosci. 2010 Oct 20;30(42):14145-52
references.pmid: 20962235
references.citation: Eur J Neurosci. 1996 Dec;8(12):2726-38
references.pmid: 8996822
references.citation: J Neurosci. 2002 Oct 15;22(20):8808-18
references.pmid: 12388587
references.citation: J Physiol. 1994 Oct 1;480 ( Pt 1):171-90
references.pmid: 7853221
references.citation: Eur J Neurosci. 1995 Nov 1;7(11):2322-33
references.pmid: 8563981
references.citation: PLoS One. 2009 Aug 13;4(8):e6623
references.pmid: 19675676
references.citation: Proc Natl Acad Sci U S A. 2010 May 4;107(18):8410-5
references.pmid: 20395550
references.citation: J Neurosci. 2004 Oct 13;24(41):9138-45
references.pmid: 15483132
references.citation: J Neurophysiol. 2010 Jul;104(1):346-65
references.pmid: 20410355
references.citation: Front Integr Neurosci. 2011 Aug 30;5:39
references.pmid: 21941469
references.citation: Acta Physiol Scand Suppl. 1962;56(193):1-61
references.pmid: 13949857
references.citation: Brain Res. 1977 Feb 18;122(2):215-28
references.pmid: 837229
references.citation: Brain Res Rev. 2006 Aug 30;52(1):93-106
references.pmid: 16497381
references.citation: Prog Brain Res. 2004;143:353-66
references.pmid: 14653179
references.citation: Eur J Neurosci. 2000 Jan;12(1):205-14
references.pmid: 10651875
references.citation: Exp Brain Res. 1990;83(1):44-54
references.pmid: 2073949
references.citation: Neuroscience. 2012 Feb 17;203:122-34
references.pmid: 22198021
references.citation: Prog Brain Res. 2005;148:259-82
references.pmid: 15661196
references.citation: Exp Brain Res. 1982;47(3):365-80
references.pmid: 6889975
references.citation: Cerebellum. 2002 Dec;1(4):289-308
references.pmid: 12879967
references.citation: J Physiol. 2008 Feb 15;586(4):1117-36
references.pmid: 18187463
references.citation: Int Rev Neurobiol. 1997;41:83-107
references.pmid: 9378614
references.citation: Cortex. 2011 Jan;47(1):137-44
references.pmid: 19786276
references.citation: Learn Mem. 2011 Oct 03;18(10):666-77
references.pmid: 21969489
references.citation: J Comp Neurol. 1984 Feb 10;223(1):110-23
references.pmid: 6200509
references.citation: Eur J Neurosci. 1989 Jan;1(6):572-586
references.pmid: 12106116
references.citation: J Neurophysiol. 2004 Feb;91(2):719-27
references.pmid: 14573551
references.citation: Prog Brain Res. 1997;114:167-92
references.pmid: 9193144
references.citation: Prog Brain Res. 2004;143:331-9
references.pmid: 14653177
references.citation: J Neurophysiol. 2000 Apr;83(4):1886-99
references.pmid: 10758100
references.citation: J Physiol. 2010 Jul 1;588(Pt 13):2373-90
references.pmid: 20442262
references.citation: Neurosci Lett. 2000 May 5;285(1):41-4
references.pmid: 10788703
references.citation: Neurosci Lett. 1981 Sep 1;25(2):125-30
references.pmid: 7279306
references.citation: Prog Brain Res. 2000;124:141-72
references.pmid: 10943123
references.citation: Neuroscience. 1986 Dec;19(4):1045-50
references.pmid: 2881226
references.citation: Cerebellum. 2008;7(4):583-8
references.pmid: 18850258
references.citation: Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8406-11
references.pmid: 12034877
references.citation: J Neurosci Res. 2006 Nov 15;84(7):1597-609
references.pmid: 16998921
references.citation: J Neurosci. 2004 May 12;24(19):4510-7
references.pmid: 15140921
references.citation: Exp Brain Res. 1979 Jul 2;36(2):219-32
references.pmid: 488197
references.citation: Neuroimage. 2011 Feb 1;54(3):1786-94
references.pmid: 20965257
references.citation: Cerebellum. 2010 Jun;9(2):249-58
references.pmid: 20169431
references.citation: Trends Neurosci. 1998 Sep;21(9):391-400
references.pmid: 9735947
references.citation: Exp Brain Res. 1977 May 23;28(1-2):189-209
references.pmid: 881003
references.citation: J Neurophysiol. 1993 Jan;69(1):57-73
references.pmid: 8433134
references.citation: Brain Res Bull. 1990 Dec;25(6):919-27
references.pmid: 2289174
references.citation: Neurology. 1994 Nov;44(11):2047-50
references.pmid: 7969957
references.citation: Behav Brain Res. 1995 Apr;68(1):1-44
references.pmid: 7619302
references.citation: J Comp Neurol. 2000 Oct 16;426(2):209-28
references.pmid: 10982464
references.citation: J Comp Neurol. 1987 Mar 22;257(4):553-77
references.pmid: 2826551
references.citation: Neuroscience. 2009 Sep 1;162(3):787-96
references.pmid: 19162131
references.citation: Brain Res. 1988 Mar 1;442(2):240-54
references.pmid: 3370446
references.citation: Brain. 1997 Oct;120 ( Pt 10):1753-62
references.pmid: 9365368
references.citation: J Physiol. 1985 Jan;358:551-70
references.pmid: 3981473
references.citation: Brain Res. 2001 Apr 6;897(1-2):150-6
references.pmid: 11282368
references.citation: Exp Brain Res. 1970;11(2):187-98
references.pmid: 4319556
references.citation: Exp Brain Res. 1997 Apr;114(2):255-70
references.pmid: 9166915
references.citation: J Anat. 2001 Jan;198(Pt 1):37-45
references.pmid: 11215766
references.citation: Exp Brain Res. 2002 Oct;146(4):511-22
references.pmid: 12355280
references.citation: Neurosci Lett. 1988 Dec 19;95(1-3):102-6
references.pmid: 2465507
references.citation: Prog Brain Res. 2006;151:321-78
references.pmid: 16221594
references.citation: J Comp Neurol. 1995 Oct 30;361(4):553-73
references.pmid: 8576414
references.citation: J Neurosci. 2006 Nov 15;26(46):12067-80
references.pmid: 17108180
references.citation: Cerebellum. 2004;3(3):172-7
references.pmid: 15543807
references.citation: J Neurophysiol. 2000 Nov;84(5):2680-90
references.pmid: 11068009
references.citation: Nat Rev Neurosci. 2005 Apr;6(4):297-311
references.pmid: 15803161
references.citation: Prog Brain Res. 2005;148:95-109
references.pmid: 15661184
references.citation: Trends Neurosci. 2006 Jun;29(6):330-8
references.pmid: 16713636
references.citation: J Physiol. 1985 Jan;358:527-49
references.pmid: 3981472
references.citation: Cerebellum. 2011 Sep;10(3):449-63
references.pmid: 20981512
references.citation: J Neurosci. 2010 Jul 14;30(28):9411-23
references.pmid: 20631170
references.citation: J Comp Neurol. 1975 May 15;161(2):215-37
references.pmid: 1055117
references.citation: Can J Physiol Pharmacol. 1996 Apr;74(4):499-512
references.pmid: 8828895
references.citation: J Physiol. 1994 Jan 15;474(2):245-60
references.pmid: 8006811
references.citation: Cereb Cortex. 2013 Feb;23(2):305-14
references.pmid: 22351647
references.citation: Brain Res. 2003 May 16;972(1-2):127-36
references.pmid: 12711085
references.citation: Brain. 1998 Apr;121 ( Pt 4):561-79
references.pmid: 9577385
references.citation: Physiol Rev. 1974 Oct;54(4):957-1006
references.pmid: 4370744
references.citation: Cerebellum. 2008;7(4):572-6
references.pmid: 18855092
references.citation: Brain. 2004 Mar;127(Pt 3):561-74
references.pmid: 14711883
references.citation: Science. 1993 May 14;260(5110):989-91
references.pmid: 8493536
references.citation: Brain Res Brain Res Rev. 2005 Sep;49(2):367-76
references.pmid: 16111563
references.citation: Cerebellum. 2007;6(3):254-67
references.pmid: 17786822
references.citation: Cerebellum. 2011 Dec;10(4):702-10
references.pmid: 21181461
references.citation: Exp Brain Res. 1969;8(4):364-86
references.pmid: 5806510
references.citation: Neuropsychologia. 1991;29(6):571-82
references.pmid: 1944862
references.citation: J Neurophysiol. 2005 Aug;94(2):1236-51
references.pmid: 16061491
references.citation: J Neurosci. 2011 Oct 12;31(41):14708-20
references.pmid: 21994387
references.citation: Neuropsychologia. 2008;46(7):1940-53
references.pmid: 18342342
references.citation: J Neurosci. 2010 Jun 30;30(26):8920-34
references.pmid: 20592214
references.citation: Ann Anat. 1994 Oct;176(5):409-18
references.pmid: 7978337
references.citation: Neuroscience. 1994 Aug;61(3):665-81
references.pmid: 7969937
references.citation: Brain Res. 1980 Apr 7;187(1):3-27
references.pmid: 7357475
references.citation: Eur J Neurosci. 2001 Jan;13(2):315-26
references.pmid: 11168536
references.citation: Exp Brain Res. 1980;39(3):261-7
references.pmid: 7398821
references.citation: J Comp Neurol. 1978 Sep 15;181(2):397-419
references.pmid: 690271
references.citation: J Neurophysiol. 2001 Apr;85(4):1461-78
references.pmid: 11287470
references.citation: Neuroimage. 2009 Jan 15;44(2):489-501
references.pmid: 18835452
references.citation: Nature. 1992 Jan 9;355(6356):163-6
references.pmid: 1370344
references.citation: J Neurophysiol. 2000 Oct;84(4):1988-2000
references.pmid: 11024092
references.citation: Cerebellum. 2008;7(4):589-94
references.pmid: 19002543
references.citation: J Physiol. 1991 Sep;441:257-74
references.pmid: 1816375
references.citation: J Neurophysiol. 1998 Feb;79(2):537-54
references.pmid: 9463420
references.citation: Trends Neurosci. 1997 Apr;20(4):177-81
references.pmid: 9106359
references.citation: Brain. 2011 Dec;134(Pt 12):3672-86
references.pmid: 22036960
references.citation: Nat Rev Neurosci. 2006 Jul;7(7):511-22
references.pmid: 16791141
references.citation: Neurosci Lett. 2004 Nov 3;370(1):25-9
references.pmid: 15489011
references.citation: Behav Brain Res. 1988 Apr-May;28(1-2):117-25
references.pmid: 2838038
references.citation: J Neurophysiol. 1972 Mar;35(2):155-69
references.pmid: 4337637
references.citation: Brain Res. 1982 Jun 17;242(1):190-3
references.pmid: 7104727
references.citation: Prog Neurobiol. 1993 Jan;40(1):63-87
references.pmid: 8424128
references.citation: Exp Brain Res. 1995;105(2):181-90
references.pmid: 7498371
references.citation: Exp Brain Res. 1987;65(2):455-64
references.pmid: 3556471
references.citation: Brain Res. 1983 May;286(3):267-97
references.pmid: 6189562
references.citation: Exp Brain Res. 1971 Oct 25;13(4):339-58
references.pmid: 5123642
references.citation: Exp Brain Res. 1994;100(3):453-68
references.pmid: 7813683
references.citation: J Comp Neurol. 1978 Jul 15;180(2):237-51
references.pmid: 659660
references.citation: J Comp Neurol. 1989 Oct 1;288(1):1-18
references.pmid: 2794133
references.citation: J Neurosci. 2006 Oct 11;26(41):10569-76
references.pmid: 17035543
references.citation: PLoS One. 2011 Apr 28;6(4):e18822
references.pmid: 21552556
references.citation: Cerebellum. 2012 Jun;11(2):336-51
references.pmid: 21240580
references.citation: J Comp Neurol. 1987 Nov 15;265(3):367-79
references.pmid: 2447133
references.citation: Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18980-4
references.pmid: 23112179
references.citation: Nature. 2011 Dec 25;481(7382):502-5
references.pmid: 22198670
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2408-12
references.pmid: 20133790
references.citation: Exp Brain Res. 1998 Feb;118(3):298-315
references.pmid: 9497138
references.citation: Neuroscience. 2002;110(1):105-21
references.pmid: 11882376
references.citation: Exp Brain Res. 1966;2(4):330-49
references.pmid: 5334534
references.citation: Cereb Cortex. 2010 Apr;20(4):953-65
references.pmid: 19684249
references.citation: Brain Res. 1974 Mar 29;69(1):140-3
references.pmid: 4817908
references.citation: Ann Neurol. 2003 May;53(5):654-8
references.pmid: 12731000
references.citation: Nat Neurosci. 2000 Oct;3(10):1049-56
references.pmid: 11017179
references.citation: J Physiol. 1981 Aug;317:1-20
references.pmid: 7310728
references.citation: J Neurosci. 1999 Dec 15;19(24):RC45
references.pmid: 10594089
references.citation: J Neurosci. 2003 Jun 1;23(11):4645-56
references.pmid: 12805304
references.citation: Prog Neurobiol. 1999 Apr;57(5):537-62
references.pmid: 10215101
references.citation: Neuroscience. 2002;111(4):863-70
references.pmid: 12031409
references.citation: Brain Res. 1977 Sep 16;133(2):237-50
references.pmid: 409452
references.citation: Trends Cogn Sci. 1998 Sep 1;2(9):322-30
references.pmid: 21227228
references.citation: Brain Res. 1983 Jan 17;259(1):127-31
references.pmid: 6824925
references.citation: J Physiol. 1988 Oct;404:241-58
references.pmid: 2855348
references.citation: Exp Brain Res. 1995;106(3):365-76
references.pmid: 8983981
references.citation: J Physiol. 1984 Jun;351:411-32
references.pmid: 6747870
references.citation: J Neurophysiol. 2010 Apr;103(4):2039-49
references.pmid: 20130039
references.citation: Proc Natl Acad Sci U S A. 1990 Apr;87(7):2662-5
references.pmid: 1969639
references.citation: Brain Res. 1995 Mar 6;673(2):313-9
references.pmid: 7606446
references.citation: Experientia. 1964 Oct 15;20(10):575-6
references.pmid: 5859224
references.citation: Exp Brain Res. 1988;72(3):450-6
references.pmid: 3234498
references.citation: J Neurosci. 2006 Dec 6;26(49):12656-63
references.pmid: 17151268
references.citation: Nat Neurosci. 2008 Nov;11(11):1256-8
references.pmid: 18820695
references.citation: J Anat. 2004 Oct;205(4):313-21
references.pmid: 15447690
references.citation: Brain. 2008 May;131(Pt 5):1332-43
references.pmid: 18334535
references.citation: J Physiol. 2002 May 15;541(Pt 1):301-17
references.pmid: 12015437
references.citation: Behav Brain Res. 1991 Aug 29;44(2):113-28
references.pmid: 1751002
references.citation: Cerebellum. 2005;4(4):290-4
references.pmid: 16321885
references.citation: Prog Brain Res. 1997;114:193-207
references.pmid: 9193145
references.citation: Exp Brain Res. 2001 Jan;136(1):41-9
references.pmid: 11204412
references.citation: Exp Brain Res. 1981;44(2):195-206
references.pmid: 7286107
references.citation: J Comp Neurol. 1963 Oct;121:173-87
references.pmid: 14066521
references.citation: J Physiol. 2011 Jul 15;589(Pt 14):3423-32
references.pmid: 21486816
references.citation: Brain Res. 1978 Aug 18;152(1):65-79
references.pmid: 679028
references.citation: Brain Res. 1993 Mar 12;605(2):207-13
references.pmid: 8481770
references.citation: J Neurosci. 2009 Aug 26;29(34):10750-63
references.pmid: 19710326
references.citation: J Physiol. 1995 Mar 15;483 ( Pt 3):687-702
references.pmid: 7776251
references.citation: J Neurophysiol. 2005 Jan;93(1):44-52
references.pmid: 15331619
references.citation: Brain Res. 1985 Sep 16;343(1):185-7
references.pmid: 4041853
references.citation: Ann N Y Acad Sci. 2002 Dec;978:79-92
references.pmid: 12582043
references.citation: J Physiol. 1979 Dec;297(0):559-80
references.pmid: 119847
references.citation: Exp Brain Res. 1987;67(2):323-38
references.pmid: 3622692
references.citation: J Neurophysiol. 1998 Mar;79(3):1255-69
references.pmid: 9497407
references.citation: Ann N Y Acad Sci. 1991;627:231-47
references.pmid: 1883138
references.citation: J Neurosci. 2007 Jun 20;27(25):6620-32
references.pmid: 17581949
references.citation: J Neurocytol. 1993 Feb;22(2):81-91
references.pmid: 8095297
references.citation: Cerebellum. 2010 Mar;9(1):103-10
references.pmid: 20013085
references.citation: J Neurosci. 1984 Nov;4(11):2811-22
references.pmid: 6502205
references.citation: J Neurosci. 2009 Jul 1;29(26):8586-94
references.pmid: 19571149
references.citation: Nat Rev Neurosci. 2009 Sep;10(9):670-81
references.pmid: 19693030
references.citation: Brain Res. 1978 Aug 18;152(1):41-63
references.pmid: 679027
references.citation: J Neurophysiol. 2004 Mar;91(3):1230-9
references.pmid: 14681334
references.citation: Front Neuroanat. 2012 Mar 14;6:8
references.pmid: 22435053
references.citation: Neurosci Lett. 2012 Aug 8;523(1):67-70
references.pmid: 22743659
references.citation: Anat Rec. 1998 Aug;253(4):118-26
references.pmid: 9740035
references.citation: Exp Neurol. 1973 Mar-Apr;39(2):307-22
references.pmid: 4634006
references.citation: Annu Rev Neurosci. 1992;15:403-42
references.pmid: 1575449
references.citation: Neuroscience. 2008 Nov 11;157(1):271-9
references.pmid: 18834931
references.citation: J Neurol Neurosurg Psychiatry. 2004 Feb;75(2):235-40
references.pmid: 14742596
references.citation: J Physiol. 1979 Apr;289:403-23
references.pmid: 458674