title: Attributable costs of ventilator-associated lower respiratory tract infection (LRTI) acquired on intensive care units: a retrospectively matched cohort study.
abstract: BACKGROUND
  Lower respiratory tract infections (LRTI) are the most common hospital-acquired infections on ICUs. They have not only an impact on each patient's individual health but also result in a considerable financial burden for the healthcare system. Our aim was to determine the costs and the length of stay of patients with ICU-acquired LRTI.
  
  
  METHODS
  We used a retrospectively matched cohort design, comparing patients with ICU-acquired LRTI and ICU patients without LRTI. LRTI was diagnosed using the definitions of the Centers for Disease Control and Prevention (CDC). Study period was from January to December 2010 analyzing patients from 10 different ICUs (medical, surgical, interdisciplinary). The device utilization ratio was defined as number of ventilator days divided by number of patient days and the device-associated LRTI rate was defined as number of ventilator associated LRTI divided by number of ventilator days. Patients were matched by age, sex, and prospectively obtained Simplified Acute Physiology Score II (SAPS II). The length of ICU stay of control patients needed to be at least as long as that of LRTI-patients before onset of LRTI. We used the Wilcoxon signed-rank test for continuous variables and the McNemar's test for categorical variables.
  
  
  RESULTS
  The analyzed ICUs had 40,772 patient days in the study period with a median ventilation utilization ratio of 56 (IQR 42-65). The median device-associated LRTI rate was 3.35 (IQR 0.96-5.36) per 1,000 ventilation days. We analyzed 49 patients with ICU-acquired LRTI and 49 respective controls without LRTI. The median hospital costs for LRTI patients were significantly higher than for patients without LRTI (45,041 € vs. 26,467 €; p < .001). The attributable costs per LRTI patient were 17,015 € (p < .001). Patients with ICU acquired LRTI stayed longer in the hospital than patients without (36 days vs. 24 days; p = 0.011). An LRTI lead to an attributable increase in length of stay by 9 days (p = 0.011).
  
  
  CONCLUSIONS
  ICU-acquired LRTI is associated with increased hospital costs and prolonged hospital stay. Hospital management should therefore implement control measurements to keep the incidence of ICU-acquired LRTI as low as possible.
authors.affiliation: Institute of Hygiene and Environmental Medicine, National Reference Center for the Surveillance of nosocomial Infections, Charité, University Medicine Berlin, Hindenburgdamm 27, Berlin, 12203, Germany. rasmus.leistner@charite.de.
authors.forename: Rasmus
authors.initials: R
authors.lastname: Leistner
authors.forename: Linda
authors.initials: L
authors.lastname: Kankura
authors.forename: Andy
authors.initials: A
authors.lastname: Bloch
authors.forename: Dorit
authors.initials: D
authors.lastname: Sohr
authors.forename: Petra
authors.initials: P
authors.lastname: Gastmeier
authors.forename: Christine
authors.initials: C
authors.lastname: Geffers
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