title: Updated role of nitric oxide in disorders of erythrocyte function.
abstract: Nitric oxide is a potent vasodilator that plays a critical role in disorders of erythrocyte function. Sickle cell disease, paroxysmal nocturnal hemoglobinuria and banked blood preservation are three conditions where nitric oxide is intimately related to dysfunctional erythrocytes. These conditions are accompanied by hemolysis, thrombosis and vasoocclusion. Our understanding of the interaction between nitric oxide, hemoglobin, and the vasculature is constantly evolving, and by defining this role we can better direct trials aimed at improving the treatments of disorders of erythrocyte function. Here we briefly discuss nitric oxide's interaction with hemoglobin through the hypothesis regarding Snitrosohemoglobin, deoxyhemoglobin, and myoglobin as nitrite reductases. We then review the current understanding of the role of nitric oxide in sickle cell disease, paroxysmal nocturnal hemoglobinuria, and banked blood, and discuss therapeutics in development to target nitric oxide in the treatment of some of these disorders.
authors.affiliation: Department of Medicine, Section of Hematology/Medical Oncology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Kahn
authors.forename: Jason H
authors.initials: JH
authors.lastname: Maley
authors.forename: George F
authors.initials: GF
authors.lastname: Lasker
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Kadowitz
mesh_terms: D000818:Animals; D017322:Clinical Trials, Phase II as Topic; D004912:Erythrocytes / Q000378:metabolism* / Q000473:pathology*; D006402:Hematologic Diseases / Q000097:blood* / Q000473:pathology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000097:blood*; D016032:Randomized Controlled Trials as Topic
chemical_list: D006454:Hemoglobins; D009569:Nitric Oxide
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