title: [Is resilience an epigenetic phenomenon?].
abstract: The likelihood of adult psychiatric problems is increased by childhood trauma, particularly so in carriers of certain alleles of certain genes. I discuss here a recent paper that sheds light on the mechanism of this effect, showing that specific demethylation occurring at the time of the initial trauma persists at adulthood and induces an increased reactivity to stress.
authors.affiliation: CoReBio PACA, case 901, parc scientifique de Luminy,13288 Marseille Cedex 9, France. bertrand.jordan@univ-amu.fr
authors.forename: Bertrand
authors.initials: B
authors.lastname: Jordan
mesh_terms: D000328:Adult; D000483:Alleles; D002648:Child; D002649:Child Abuse / Q000523:psychology; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D011965:Receptors, Glucocorticoid / Q000502:physiology; D055500:Resilience, Psychological; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics; D013315:Stress, Psychological / Q000523:psychology; D022021:Tacrolimus Binding Proteins / Q000235:genetics; D000099159:Tacrolimus Binding Protein 5
chemical_list: D011965:Receptors, Glucocorticoid; D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5