title: Longitudinal MRI study of the midline brain regions in first-episode schizophrenia.
abstract: This magnetic resonance imaging (MRI) study investigated the prevalence and size of the adhesio interthalamica (AI) and cavum septi pellucidi (CSP) in 64 first-episode schizophrenia patients and 64 controls, of whom longitudinal data were available for 20 patients and 21 controls. The AI was shorter in the patients and showed longitudinal decline in both groups; there was also a trend for AI atrophy to correlate with negative symptoms. The CSP showed no group difference. These results suggest a role for the AI as a possible neurodevelopmental marker of schizophrenia.
authors.affiliation: Department of Neuropsychiatry, University of Toyama, Toyama, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan. tsutomu@med.u-toyama.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Kazue
authors.initials: K
authors.lastname: Nakamura
authors.forename: Eiji
authors.initials: E
authors.lastname: Ikeda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Furuichi
authors.forename: Mikio
authors.initials: M
authors.lastname: Kido
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Kyo
authors.initials: K
authors.lastname: Noguchi
authors.forename: Hikaru
authors.initials: H
authors.lastname: Seto
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000473:pathology*; D055815:Young Adult