title: Effectiveness of Bufei Yishen Granule combined with acupoint sticking therapy on quality of life in patients with stable chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  To evaluate the efficacy of Bufei Yishen Granule BFYSG) combined with Shufei Tie acupoint sticking therapy on quality of life of patients with stable chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  A multi-center, double-blinded, double-dummy and randomized controlled method was adopted in this trial. A total of 244 patients were randomly assigned to a trial group and a control group according to the random number, each with 122 patients; treatment allocation occurred when the participants met the inclusion criteria and signed the informed consent form. In the trial group, patients were treated with BFYSG combined with "Shufei Tie" acupoint sticking therapy and sustained-release theophylline dummy, and in the control group patients were treated with oral sustained-release theophylline and BFYSG dummy combined with "Shufei Tie" acupoint sticking therapy dummy. The therapeutic course for two groups was 4 months and the follow-up was 6 months. The frequency and duration of acute exacerbation calculated by adding up each frequency and duration of acute exacerbation in treatment and follow-up time respectively, the quality of life measured by the World Health Organization Quality of Life (WHOQOL)-BREF scale and adult COPD quality of life (COPD-QOL) scale were observed.
  
  
  RESULTS
  Among the 244 enrolled patients, 234 were screened for full analysis set (FAS); 221 were screened for per-protocol analysis set (PPS). After 4-month treatment and 6-month follow-up there were differences between the trial group and the control group in frequency of acute exacerbation (FAS: P=0.013; PPS: P=0.046); duration of acute exacerbation (FAS: P=0.005; PPS: P=0.006); scores of physiological, psychological and environment aspects of the WHOQOL-BREF questionnaire (FAS: P=0.002, P=0.006, P=0.000; PPS: P=0.00, P=0.001, P=0.000); scores of daily living ability, social activity, depression symptoms aspects of the COPD-QOL questionnaire (FAS: P=0.000, P=0.000, P=0.006; PPS: P=0.002, P=0.001, P=0.001).
  
  
  CONCLUSIONS
  BFYSG combined with acupoint sticking therapy could improve the quality of life of patients with stable COPD.
authors.affiliation: Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xie
authors.forename: Jian-Sheng
authors.initials: JS
authors.lastname: Li
authors.forename: Xue-Qing
authors.initials: XQ
authors.lastname: Yu
authors.forename: Su-Yun
authors.initials: SY
authors.lastname: Li
authors.forename: Nian-Zhi
authors.initials: NZ
authors.lastname: Zhang
authors.forename: Ze-Geng
authors.initials: ZG
authors.lastname: Li
authors.forename: Su-Ju
authors.initials: SJ
authors.lastname: Shao
authors.forename: Lian-Xiang
authors.initials: LX
authors.lastname: Guo
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Yi-Jie
authors.initials: YJ
authors.lastname: Zhang
mesh_terms: D015669:Acupuncture Points; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000150:complications / Q000523:psychology; D003131:Combined Modality Therapy; D003863:Depression / Q000150:complications / Q000523:psychology; D018450:Disease Progression; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: C574914:Bu-Fei-Yi-Shen; D004365:Drugs, Chinese Herbal
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