title: Computational approach for designing tumor homing peptides.
abstract: Tumor homing peptides are small peptides that home specifically to tumor and tumor associated microenvironment i.e. tumor vasculature, after systemic delivery. Keeping in mind the huge therapeutic importance of these peptides, we have made an attempt to analyze and predict tumor homing peptides. It was observed that certain types of residues are preferred in tumor homing peptides. Therefore, we developed support vector machine based models for predicting tumor homing peptides using amino acid composition and binary profiles of peptides. Amino acid composition, dipeptide composition and binary profile-based models achieved a maximum accuracy of 86.56%, 82.03%, and 84.19% respectively. These methods have been implemented in a user-friendly web server, TumorHPD. We anticipate that this method will be helpful to design novel tumor homing peptides. TumorHPD web server is freely accessible at http://crdd.osdd.net/raghava/tumorhpd/.
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Sharma
authors.forename: Pallavi
authors.initials: P
authors.lastname: Kapoor
authors.forename: Ankur
authors.initials: A
authors.lastname: Gautam
authors.forename: Kumardeep
authors.initials: K
authors.lastname: Chaudhary
authors.forename: Rahul
authors.initials: R
authors.lastname: Kumar
authors.forename: Jagat Singh
authors.initials: JS
authors.lastname: Chauhan
authors.forename: Atul
authors.initials: A
authors.lastname: Tyagi
authors.forename: Gajendra P S
authors.initials: GP
authors.lastname: Raghava
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D015195:Drug Design; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000737:chemistry* / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry* / Q000493:pharmacokinetics*; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*
chemical_list: D010455:Peptides
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