title: Enhancing the Cellular Delivery of Nanoparticles using Lipo-Oligoarginine Peptides.
abstract: Nanoparticles have great potential as nanotherapeutics, delivery vectors, and molecular imaging agents due to their flexible properties. Although intracellular and nuclear delivery of nanoparticles is desirable for therapeutic applications, it remains a challenge. Cell penetrating peptides (CPPs) are a powerful tool for the intracellular delivery of various cargoes. Here we report that functionalization of nanoparticles with a myristoylated oligoarginine CPP promoted cellular uptake without increased toxicity. It was evidenced that the myristoylated CPP is much more effective in transporting nanoparticles than the unmodified CPPs.
authors.affiliation: Department of Translational Imaging, The Methodist Hospital Research Institute, Weill Cornell Medical College, 6565 Fannin, B5-009, Houston, TX 77030 (U.S.).
authors.forename: Jae Sam
authors.initials: JS
authors.lastname: Lee
authors.forename: Ching-Hsuan
authors.initials: CH
authors.lastname: Tung
keywords: cell penetrating peptides; cellular uptake; gold; lipo-oligoarginine peptide; nanoparticles
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