title: Current situation of clinical trials in Beijing and Shanghai, China.
abstract: OBJECTIVE
  Global clinical trials are important because they facilitate rapid delivery of new and effective drugs to patients Assessment of the current situation of clinical trials conducted in Asia is critical for improving performance of global clinical trials. However, review reports from China or other Asian countries are not yet available. Therefore, the purpose of this research was to investigate the current quality of clinical trials conducted in Shanghai, as well as Beijing.
  
  
  METHODS
  Questionnaires were distributed to medical doctors attending institutes in Beijing and Shanghai in which clinical trials have been conducted. These questionnaires were delivered and collected from both areas by the Peking University research team of Beijing and the Fudan University research team of Shanghai respectively. Analysis and evaluation were conducted by research teams from both China and Japan.
  
  
  RESULTS
  Subjects were randomly selected by the respective research team. A total of 145 questionnaires in Beijing and 162 in Shanghai were administered: all 307 questionnaires were completed. In total, 57.2% and 74.5% of respondents from Beijing and Shanghai, respectively, reported participation in audits and inspections on an annual basis conducted by their own institute. A total of 49.2% and 56.0% of respondents from Beijing and Shanghai, respectively, reported that they received reports after the audits and inspections by an institute. 23.5% and 37.7% of respondents from Beijing and Shanghai, respectively, reported participation in audits conducted annually by external authorities. A total of 18.9% and 29.5% of respondents from Beijing and Shanghai, respectively, reported that they received reports after the audits and inspections by an external authority.
  
  
  CONCLUSIONS
  Our research suggests that clinical trials in Shanghai, as well as in Beijing, are conducted vigorously and appropriately monitored by audits and inspections conducted by concerned institutes and/or by an external authority.
authors.affiliation: Young Leaders' Program of Health Care Administration, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan. yoshidayoshitoku@med.nagoya-u.ac.jp
authors.forename: Yoshitoku
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Di
authors.initials: D
authors.lastname: Xue
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Yumei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Defu
authors.initials: D
authors.lastname: Ma
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Sato
authors.forename: Peiyu
authors.initials: P
authors.lastname: Wang
mesh_terms: D000047:Academies and Institutes / Q000592:standards*; D000328:Adult; D016009:Chi-Square Distribution; D002681:China; D002983:Clinical Competence / Q000592:standards; D002986:Clinical Trials as Topic / Q000379:methods / Q000592:standards*; D003284:Contract Services / Q000592:standards; D004502:Education, Medical, Continuing / Q000592:standards; D005260:Female; D019983:Guideline Adherence; D019538:Health Care Surveys; D006801:Humans; D008297:Male; D008485:Medical Audit / Q000592:standards; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012107:Research Design / Q000592:standards*; D012108:Research Personnel / Q000592:standards; D011795:Surveys and Questionnaires