title: New hydrogel obtained from a novel dendritic monomer as a promising candidate for biomedical applications.
abstract: Acid functional hydrogels are a type of materials with many advantages. Over the last years, increasing attention for the synthesis of dendronized polymers has been drawn due to their unique properties of high multivalence in the same surface as compared with conventional polymers. In this study, we report the preparation of novel acid dendronized hydrogels using a dendritic monomer obtained from Behera's amine. The swelling and rheological performance, the non-toxicity over fibroblast cells and the drug encapsulation capacity of the novel hydrogels suggests that the new materials can achieve great potential as carrier for drug delivery and other potential biomedical applications.
authors.affiliation: Departamento de Química Orgánica, IMBIV-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina.
authors.forename: Julio César
authors.initials: JC
authors.lastname: Cuggino
authors.forename: Germán
authors.initials: G
authors.lastname: Charles
authors.forename: Gerardo
authors.initials: G
authors.lastname: Gatti
authors.forename: Miriam Cristina
authors.initials: MC
authors.lastname: Strumia
authors.forename: Cecilia Inés
authors.initials: CI
authors.lastname: Alvarez Igarzabal
mesh_terms: D000818:Animals; D002470:Cell Survival; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D058105:Polymerization; D011108:Polymers / Q000737:chemistry; D011522:Protons; D012212:Rheology
chemical_list: D050091:Dendrimers; D011108:Polymers; D011522:Protons; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: biomaterials; dendronized polymers; drug carriers; hydrogels; soft materials