title: Determining the role of cystectomy for high-grade T1 urothelial carcinoma.
abstract: High-grade T1 (HGT1) urothelial carcinoma is an invasive disease with high predisposition for recurrence and progression. The optimal treatment of HGT1 disease remains controversial. Clinical HGT1 disease represents a heterogeneous group of patients with variable clinical behavior. Radical cystectomy for HGT1 disease is associated with excellent survival and offers the best opportunity for cure; however, it has a potential cost of decrease in quality of life. This article summarizes features associated with increased risk of progression and provides a framework for optimal treatment strategy with a focus on the role of radical cystectomy for HGT1 disease.
authors.affiliation: USC Institute of Urology, Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA. daneshma@usc.edu
authors.forename: Siamak
authors.initials: S
authors.lastname: Daneshmand
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D015653:Cystectomy; D018450:Disease Progression; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*