title: Cloning of a hamster anti-mouse CD79B antibody sequences and identification of a new hamster immunoglobulin lambda constant IGLC gene region.
abstract: Anti-CD79 antibodies have been effective at targeting B cell lymphoma cells and depleting B cells in animal models. In order to engineer recombinant antibodies with additional effector functions in mice, we cloned and sequenced the full-length cDNAs of the heavy and light chain of a hamster anti-mouse CD79B antibody. Although hamster antibodies represent a unique source of monoclonal antibodies against mouse, rat, and human antigens, sequence information of hamster immunoglobulins (IG) is sparse. Here, we report a new hamster (Cricetulus migratorius) IG lambda constant (IGLC) gene region that is most homologous to mouse IGLC2 and IGLC3.
authors.affiliation: Department of Medicine, Section of Rheumatology, Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Haggart
authors.forename: Jason
authors.initials: J
authors.lastname: Perera
authors.forename: Haochu
authors.initials: H
authors.lastname: Huang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D051925:CD79 Antigens / Q000276:immunology*; D003001:Cloning, Molecular; D006224:Cricetinae; D007127:Immunoglobulin Constant Regions / Q000235:genetics* / Q000276:immunology; D007146:Immunoglobulin lambda-Chains / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny
chemical_list: D000911:Antibodies, Monoclonal; D051925:CD79 Antigens; D007127:Immunoglobulin Constant Regions; D007146:Immunoglobulin lambda-Chains
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