title: Asymptomatic cardiac toxicity in long-term cancer survivors: defining the population and recommendations for surveillance.
abstract: Advances in the treatment of pediatric and adult cancer have reduced the mortality rates from these disorders and have led to an ever-increasing population of long-term survivors. Chemotherapy and radiotherapy may cause premature cardiac disease that may be asymptomatic or symptomatic. All patients exposed to chemotherapy with cardiotoxic potential or chest radiotherapy have stage A heart failure and the goal of surveillance and treatment is to prevent progression to stages B-D. Screening strategies, including the use of biomarkers, echocardiography, and expert opinion surveillance and treatment recommendations, are presented.
authors.affiliation: Cardio-oncology in the Division of Cardiology, University of Pennsylvania, Philadelphia, PA 19104, USA. jrc@mail.med.upenn.edu
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Carver
authors.forename: Dava
authors.initials: D
authors.lastname: Szalda
authors.forename: Bonnie
authors.initials: B
authors.lastname: Ky
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D058070:Asymptomatic Diseases / Q000453:epidemiology*; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D062665:Epidemiological Monitoring; D006801:Humans; D008403:Mass Screening; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D011153:Population; D017410:Practice Guidelines as Topic; D011832:Radiation Injuries / Q000453:epidemiology / Q000209:etiology; D017741:Survivors
chemical_list: D000970:Antineoplastic Agents
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