title: The remedial effect of soluble interleukin-1 receptor type II on endometriosis in the nude mouse model.
abstract: OBJECTIVE
  Recent studies have shown that the local expression of soluble interleukin (IL) -1 receptor type II (sIL-1 RII) in endometrial tissue of women with endometriosis is decreased, and the depression of IL-1 RII was more significant in infertile women than that in fertile women with endometriosis. In this research, we investigated the remedial effect of sIL-1-RII administration on endometriosis in the nude mouse model.
  
  
  METHODS
  NINETEEN NUDE MODEL MICE WITH ENDOMETRIOSIS WERE RANDOMLY DIVIDED INTO THREE GROUPS: group A was treated by intraperitoneal administration with only sIL-1 RII for two weeks, group B was similarly treated with only IL-1, and group C (control) was administered saline . After 2 weeks, the size of the ectopic endometrial lesions was calculated, and the expression of vascular endothelial growth factor (VEGF) and B-cell lymphoma leukemia-2 (Bcl-2) were detected by immunohistochemistry. The IL-8 and VEGF levels in the peritoneal fluid (PF) and serum were also measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The mean size of ectopic endometrial lesion did not differ between the three groups (P > 0.05). Compared with the control, the expression of VEGF and Bcl-2 was significantly lower in group A, and higher in group B. In the three groups, the levels of IL-8 in the PF and serum were highest in group A, and lowest in group B.
  
  
  CONCLUSIONS
  sIL-1 RII may suppresse hyperplasia of ectopic endometriosis, perhaps by reducing the expression of certain cytokines, such as VEGF, IL-8, and Bcl-2, which could provide a new clinical strategy for the treatment of endometriosis.
authors.affiliation: Center of Clinical Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029 ; Suzhou Municipal Hospital & Suzhou Medical Center for Maternal and Child Health, Suzhou 215002, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Gao
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.forename: Yugui
authors.initials: Y
authors.lastname: Cui
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hou
authors.forename: Li
authors.initials: L
authors.lastname: Gao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Yundong
authors.initials: Y
authors.lastname: Mao
authors.forename: Suping
authors.initials: S
authors.lastname: Han
authors.forename: Jiayin
authors.initials: J
authors.lastname: Liu
keywords: Interleukin-1; endometriosis; nude mouse model; soluble interleukin-1 receptor type II
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