title: Intracerebral metastasis in pediatric acute lymphoblastic leukemia: A rare presentation.
abstract: Central nervous system leukemia may present in different ways. However, intraparenchymal mass is extremely rare in childhood leukemia. Herein, we report a boy who presented with right hemiparesis and anisocoria 1 year after the cessation of the chemotherapy protocol for acute lymphoblastic leukemia. Cranial imaging demonstrated an extensive mass located in the anterior white matter of left frontal lobe, and cerebrospinal fluid examination revealed concomitant lymphoblasts. Immunohistochemical staining of the biopsy material showed neoplastic cells with positive CD10 and TdT. Complete remission was achieved with chemotherapy alone for a duration of 2 years.
authors.affiliation: School of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Müge
authors.initials: M
authors.lastname: Gokce
authors.forename: Selin
authors.initials: S
authors.lastname: Aytac
authors.forename: Ilhan
authors.initials: I
authors.lastname: Altan
authors.forename: Sule
authors.initials: S
authors.lastname: Unal
authors.forename: Murat
authors.initials: M
authors.lastname: Tuncer
authors.forename: Fatma
authors.initials: F
authors.lastname: Gumruk
authors.forename: Mualla
authors.initials: M
authors.lastname: Cetin
keywords: Acute lymphoblastic leukemia; central nervous system relapse; intracerebral mass
references.citation: Leukemia. 2010 Feb;24(2):371-82
references.pmid: 20010620
references.citation: Lancet Oncol. 2008 Mar;9(3):257-68
references.pmid: 18308251
references.citation: Acta Clin Croat. 2008 Mar;47(1):19-24
references.pmid: 18714643
references.citation: Leukemia. 2009 Aug;23(8):1406-9
references.pmid: 19282835
references.citation: J Clin Oncol. 2003 Jan 15;21(2):184-8
references.pmid: 12525508
references.citation: Cancer. 1973 Mar;31(3):520-33
references.pmid: 4511909
references.citation: J Clin Med Res. 2010 Oct 11;2(5):225-9
references.pmid: 21331151
references.citation: Blood. 1992 May 1;79(9):2432-7
references.pmid: 1373974
references.citation: N Engl J Med. 2006 Jan 12;354(2):166-78
references.pmid: 16407512
references.citation: J Neurooncol. 2006 Oct;80(1):101-4
references.pmid: 16645713
references.citation: Turk J Pediatr. 2004 Apr-Jun;46(2):115-9
references.pmid: 15214738
references.citation: Med Pediatr Oncol. 1996 Feb;26(2):129-34
references.pmid: 8531851
references.citation: Leuk Lymphoma. 2010 Feb;51(2):261-8
references.pmid: 20038226
references.citation: J Clin Oncol. 1993 Feb;11(2):271-8
references.pmid: 8426204