title: Eyes on DNA methylation: current evidence for DNA methylation in ocular development and disease.
abstract: Epigenetic modulation of chromatin states constitutes a vital component of the cellular repertoire of transcriptional regulatory mechanisms. The development of new technologies capable of generating genome-wide maps of chromatin modifications has re-energized the field. We are now poised to determine how species- and tissue-specific patterns of DNA methylation, in concert with other chromatin modifications, function to establish and maintain cell- and tissue-specific patterns of gene expression during normal development, cellular differentiation, and disease. This review addresses our current understanding of the major mechanisms and function of DNA methylation in vertebrates with a historical perspective and an emphasis on what is known about DNA methylation in eye development and disease.
authors.affiliation: Department of Basic and Vision Sciences, College of Optometry, University of Houston, 4901 Calhoun Rd, Rm 2195, Houston, TX 77204-2020 USA ; Department of Biology and Biochemistry, College of Natural Sciences and Mathematics, University of Houston, Houston, TX 77204-2020 USA.
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Otteson
keywords: DNA methylation; Lens; Müller glia; Ocular cancer; Retina; Transcriptional regulation
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