title: Apelin and vascular endothelial growth factor are associated with mobilization of endothelial progenitor cells after acute myocardial infarction.
abstract: This study was designed to determine the levels of early endothelial progenitor cells (EPCs), apelin, vascular endothelial growth factor (VEGF) and stromal cell-derived growth factor-1 (SDF-1) after acute myocardial infarction (AMI), and to investigate the relationships between these cytokines and early EPCs. Early EPCs, defined as CD133(+), KDR(+), and CD34(+) cells, were quantified by flow cytometry. The levels of early EPCs and those cytokines in AMI patients were significantly different from those with coronary artery disease or controls (P < 0.05). Plasma apelin levels were inversely correlated with Gensini score and early EPCs (both P < 0.01). Early EPCs, VEGF and SDF-1 showed different patterns of changes in AMI patients during the first 24 h. The trend in the change of early EPCs was proportionally correlated with that of VEGF (P < 0.05). AMI patients exhibited increased early EPCs with remarkably decreased apelin levels and enhanced VEGF levels.
authors.affiliation: Department of Cardiology, Drum Tower Clinical College Affiliated with Nanjing Medical University, Nanjing, Jiangsu 210008, China;
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Ye
authors.forename: Ping
authors.initials: P
authors.lastname: Ni
authors.forename: Lina
authors.initials: L
authors.lastname: Kang
authors.forename: Biao
authors.initials: B
authors.lastname: Xu
keywords: apelin; endothelial progenitor cells (EPCs); stromal cell-derived growth factor-1 (SDF-1); vascular endothelial growth factor (VEGF)
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