title: Drug embedded PVP coated magnetic nanoparticles for targeted killing of breast cancer cells.
abstract: Magnetic drug targeting is a drug delivery system that can be used in loco-regional cancer treatment. Coated magnetic particles, called carriers, are very useful for delivering chemotherapeutic drugs. Magnetic carriers were synthesized by co-precipitation of iron oxide followed by coating with polyvinyl pyrrolidone (PVP). Characterization was performed using X-ray diffraction, TEM, TGA, FTIR and UV-Vis Spectroscopy. Magnetite (Fe3O4) remained as the core of the carrier. The amount of PVP bound to the iron oxide nanoparticles was estimated by thermogravimetric analysis (TGA) and the attachment of PVP to the iron oxide nanoparticles confirmed by FTIR analysis. The loading efficiency of Epirubicin hydrochloride onto the PVP coated and uncoated iron oxide nanoparticles was measured at intervals such as 1 hr and 24 hrs by UV-Vis Spectroscopy. The binding of Epirubicin hydrochloride to the PVP coated and uncoated iron oxide nanoparticles were confirmed by FTIR analysis. The present findings showed that Epirubicin hydrochloride loaded PVP coated iron oxide nanoparticles are promising for magnetically targeted drug delivery. The drug displayed increased cell cytotoxicity at lower concentrations when conjugated with the nanoparticles than being administered conventionally as individual drugs.
authors.affiliation: Department of Nanoscience and Technology, Udaya School of Engineering, Vellamodi, Kanyakumari District, Tamil Nadu, India. crkpkp@gmail.com.
authors.forename: P Arsula
authors.initials: PA
authors.lastname: Rose
authors.forename: P K
authors.initials: PK
authors.lastname: Praseetha
authors.forename: Madhulika
authors.initials: M
authors.lastname: Bhagat
authors.forename: Princy
authors.initials: P
authors.lastname: Alexander
authors.forename: Sunitha
authors.initials: S
authors.lastname: Abdeen
authors.forename: Murthy
authors.initials: M
authors.lastname: Chavali
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis*; D016503:Drug Delivery Systems; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005492:Folic Acid; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy*; D058185:Magnetite Nanoparticles / Q000737:chemistry; D008297:Male; D010592:Pharmaceutic Aids / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000903:Antibiotics, Antineoplastic; D020099:Coated Materials, Biocompatible; D058185:Magnetite Nanoparticles; D010592:Pharmaceutic Aids; D015251:Epirubicin; D005492:Folic Acid; D011205:Povidone