title: Clinical and prognostic significance of coagulation assays in gastric cancer.
abstract: OBJECTIVE
  Activation of coagulation and fibrinolysis is frequently found among cancer patients. Such tumors are considered to be associated with a higher risk of invasion, metastases, and eventually, worse outcome. The aim of this study is to explore the clinical and prognostic value of blood coagulation tests in gastric cancer (GC) patients.
  
  
  METHODS
  A total of 44 consecutive patients with a pathologically confirmed diagnosis of GC were enrolled into the study. Pretreatment blood coagulation tests including prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), D-dimer (DD), fibrinogen (F) levels, and platelet (PLT) counts were evaluated. Control group comprised 50 age- and sex-matched individuals without history of malignancy and coagulation disorder.
  
  
  RESULTS
  Median age at diagnosis was 55 years, range 19-80 years; most had men (n = 32, 73 %) and metastatic disease (n = 31, 70 %). The level of blood coagulation tests showed a statistically significant difference between the patient and the control groups (P < 0.001 for all, but p = 0.07 for PT). DD levels were significantly associated with elevated PLT and LDH levels (p = 0.009 and p = 0.01, respectively). Patients with metastatic disease had higher levels of F (p = 0.001) and INR (p = 0.027) levels. Elevated DD levels tended to be a poor prognostic factor on outcome (p = 0.06).
  
  
  CONCLUSIONS
  Change in almost all coagulation tests are found in GC patients and only DD level seems to be of prognostic value.
authors.affiliation: Institute of Oncology, University of Istanbul, Istanbul, Turkey. faruktas2002@yahoo.com
authors.forename: Faruk
authors.initials: F
authors.lastname: Tas
authors.forename: Rumeysa
authors.initials: R
authors.lastname: Ciftci
authors.forename: Leyla
authors.initials: L
authors.lastname: Kilic
authors.forename: Murat
authors.initials: M
authors.lastname: Serilmez
authors.forename: Senem
authors.initials: S
authors.lastname: Karabulut
authors.forename: Derya
authors.initials: D
authors.lastname: Duranyildiz
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality* / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001780:Blood Coagulation Tests; D018279:Carcinoma, Signet Ring Cell / Q000378:metabolism / Q000401:mortality* / Q000556:secondary; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010976:Platelet Count; D011379:Prognosis; D011517:Prothrombin Time; D013274:Stomach Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005340:Fibrinogen
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