title: Gene polymorphisms and thyroid function in patients with heart failure.
abstract: We evaluated nuclear factor kappa B {NFkB, rs28362491 [-94ins/delATTG (W/D)]} and angiotensin converting enzyme {ACE; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF). Peak oxygen uptake (VO(2)) was evaluated (by Weber classification) during a symptom-limited cardiopulmonary exercise test in 194 patients. Thyroid-stimulating hormone, triiodothyronine (T3), thyroxine (T4), and free (F) T3 and FT4 were also measured. According to their cardiovascular (CV) capacity, patients were subdivided into four groups: group A included patients with peak VO(2) >20 ml/kg/min, group B 16-20 ml/kg/min, group C 10-16 ml/kg/min, and group D 6-10 ml/kg/min. Patients were also genotyped for NFkB and ACE genetic variants. T3 was increased and FT3 was decreased for every raise in Weber's classification (p = 0.007 and p = 0.012, respectively). Del carriers had elevated FT3 levels compared with Ins carriers (p = 0.021). Patients with II genotype had elevated T4 levels compared with ID genotype (p = 0.044). Both T4 and FT4 were decreased in D allele carriers (p = 0.007 and p = 0.045, respectively). Thyroid hormones correlated with CV capacity. Associations between the NFkB and ACE gene polymorphisms and thyroid hormones levels were also observed. Further larger studies are required to clarify genes contribution in HF.
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center Athens, 356 Sygrou Ave, 176 74, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vasiliadis
authors.forename: Genovefa
authors.initials: G
authors.lastname: Kolovou
authors.forename: Vana
authors.initials: V
authors.lastname: Kolovou
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Giannakopoulou
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.forename: Niki
authors.initials: N
authors.lastname: Katsiki
authors.forename: Evaggelia
authors.initials: E
authors.lastname: Papadopoulou
authors.forename: Sophie
authors.initials: S
authors.lastname: Mavrogeni
authors.forename: Konstantina
authors.initials: K
authors.lastname: Sorontila
authors.forename: Costas
authors.initials: C
authors.lastname: Pantos
authors.forename: Dennis V
authors.initials: DV
authors.lastname: Cokkinos
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006333:Heart Failure / Q000097:blood / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; D014284:Triiodothyronine; D013972:Thyrotropin; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A; D013974:Thyroxine
references.citation: Endocrine. 2011 Jun;39(3):266-71
references.pmid: 21387129
references.citation: Mayo Clin Proc. 2010 Feb;85(2):180-95
references.pmid: 20118395
references.citation: Endocrinology. 1999 Jul;140(7):3170-6
references.pmid: 10385411
references.citation: Circulation. 1997 May 20;95(10):2358-67
references.pmid: 9170397
references.citation: J Clin Endocrinol Metab. 2009 Apr;94(4):1251-4
references.pmid: 19158193
references.citation: Eur J Heart Fail. 2001 Oct;3(5):577-85
references.pmid: 11595606
references.citation: Endocrine. 2010 Feb;37(1):148-56
references.pmid: 20963564
references.citation: Am J Hypertens. 2011 Sep;24(9):1027-34
references.pmid: 21654857
references.citation: Coron Artery Dis. 2007 May;18(3):153-7
references.pmid: 17429286
references.citation: Med Clin North Am. 2012 Mar;96(2):257-68
references.pmid: 22443974
references.citation: Angiology. 2013 Apr;64(3):173-80
references.pmid: 22649110
references.citation: J Hypertens. 2012 Sep;30(9):1681-9
references.pmid: 22828089
references.citation: Circulation. 2007 Jul 17;116(3):329-43
references.pmid: 17576872
references.citation: Clin Genet. 2002 Jan;61(1):21-5
references.pmid: 11903350
references.citation: Hum Mol Genet. 2004 Jan 1;13(1):35-45
references.pmid: 14613970
references.citation: Circ Res. 1994 Aug;75(2):245-51
references.pmid: 8033338
references.citation: J Am Coll Cardiol. 2003 Mar 5;41(5):729-36
references.pmid: 12628714
references.citation: Recent Pat Cardiovasc Drug Discov. 2008 Jan;3(1):19-27
references.pmid: 18221125
references.citation: Int J Cardiol. 2008 Sep 16;129(1):86-92
references.pmid: 17707926
references.citation: J Am Coll Cardiol. 2001 Aug;38(2):307-14
references.pmid: 11499717
references.citation: Oncogene. 1999 Nov 22;18(49):6853-66
references.pmid: 10602461
references.citation: N Engl J Med. 2001 Feb 15;344(7):501-9
references.pmid: 11172193
references.citation: Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5251-5
references.pmid: 1376915
references.citation: Inflamm Bowel Dis. 2006 Jul;12(7):606-11
references.pmid: 16804398
references.citation: BMC Med Genet. 2010 Jun 09;11:89
references.pmid: 20534156
references.citation: Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E765-70
references.pmid: 17090750
references.citation: J Clin Endocrinol Metab. 2004 Jul;89(7):3276-84
references.pmid: 15240603
references.citation: Endocrinology. 1979 May;104(5):1467-73
references.pmid: 108095
references.citation: Mol Cell Biochem. 2012 Feb;361(1-2):297-304
references.pmid: 22015653
references.citation: J Am Coll Cardiol. 1986 May;7(5):967-74
references.pmid: 3958379
references.citation: Am J Respir Crit Care Med. 2003 Jan 15;167(2):211-77
references.pmid: 12524257
references.citation: Arch Intern Med. 2005 Nov 28;165(21):2460-6
references.pmid: 16314541
references.citation: Circulation. 2005 Sep 20;112(12):e154-235
references.pmid: 16160202
references.citation: Exp Biol Med (Maywood). 2001 Jun;226(6):552-8
references.pmid: 11395925
references.citation: Endocrine. 2010 Oct;38(2):283-8
references.pmid: 20972734
references.citation: Heart Fail Rev. 2010 Mar;15(2):155-69
references.pmid: 19110971
references.citation: Nucleic Acids Res. 1992 Mar 25;20(6):1433
references.pmid: 1313972
references.citation: Clin Cardiol. 1999 Sep;22(9):587-90
references.pmid: 10486698
references.citation: Mol Cell Biochem. 2012 Apr;363(1-2):235-43
references.pmid: 22134702
references.citation: BMC Med Genet. 2009 May 31;10:47
references.pmid: 19480714
references.citation: Eur J Endocrinol. 2007 Oct;157(4):515-20
references.pmid: 17893267
references.citation: J Am Coll Cardiol. 2009 Apr 14;53(15):e1-e90
references.pmid: 19358937
references.citation: Eur J Endocrinol. 2011 Jul;165(1):107-14
references.pmid: 21490121
references.citation: N Engl J Med. 1971 Dec 23;285(26):1441-6
references.pmid: 5122894
references.citation: Circulation. 1997 Jul 15;96(2):592-8
references.pmid: 9244231
references.citation: Am J Cardiol. 1994 Feb 15;73(5):374-8
references.pmid: 8109552