title: Concurrent choice for social interaction and amphetamine using conditioned place preference in rats: effects of age and housing condition.
abstract: BACKGROUND
  Social interaction can serve as a natural reward that attenuates drug reward in rats; however, it is unknown if age or housing conditions alter the choice between social interaction and drug.
  
  
  METHODS
  Individually- and pair-housed adolescent and adult male rats were tested using conditioned place preference (CPP) in separate experiments in which: (1) social interaction was conditioned against no social interaction; (2) amphetamine (AMPH; 1mg/kg, s.c.) was conditioned against saline; or (3) social interaction was conditioned against AMPH.
  
  
  RESULTS
  Social interaction CPP was obtained only in individually-housed adolescents, whereas AMPH CPP was obtained in both individually-housed adolescents and adults; however, the effect of AMPH was not statistically significant in pair-housed adults. When allowed to choose concurrently between compartments paired with either social interaction or AMPH, individually-housed adolescents preferred the compartment paired with social interaction, whereas pair-housed adolescents preferred the compartment paired with AMPH. Regardless of housing condition, adults showed a similar preference for the compartments paired with either social interaction or AMPH.
  
  
  CONCLUSIONS
  Although some caution is needed in interpreting cross-experiment comparisons, the overall results suggest that individually-housed adolescents were most sensitive to the rewarding effect of social interaction, and this hypersensitivity to social reward effectively competed with AMPH reward.
authors.affiliation: Department of Psychology, University of Kentucky, Lexington, KY 40536, USA.
authors.forename: Justin R
authors.initials: JR
authors.lastname: Yates
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Beckmann
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Meyer
authors.forename: Michael T
authors.initials: MT
authors.lastname: Bardo
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology / Q000523:psychology*; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects* / Q000502:physiology; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D006799:Housing, Animal; D007398:Interpersonal Relations; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000661:Amphetamine
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