title: Efficacy of telbivudine on interruption of hepatitis B virus vertical transmission: a meta-analysis.
abstract: OBJECTIVE
  Hepatitis B virus (HBV) infection is one of the most common infections in the world. Vertical transmission is the main reason for the continued endemic infection rates, at least in Asia. This study aimed to investigate the efficacy of telbivudine on mother-to-child transmission (MTCT) interruption.
  
  
  METHODS
  Studies up to April 2012 were collected by searching Pubmed, EMBASE, the Cochrane Library, EBM Review, WangFang Database and China National Knowledge Infrastructure. Serum hepatitis B surface antigen (HBsAg) and HBV DNA in newborns and infants, maternal HBV DNA negative conversion and alanine trans.aminase (ALT) normalization and adverse events were analyzed.
  
  
  RESULTS
  Seven clinical trials involving 644 pregnant women were included in this meta-analysis. Telbivudine resulted in lower HBsAg and HBV DNA seroprevalence in newborns and infants. When maternal viral load prior to delivery was higher than 103copies/mL, HBsAg or HBV DNA positivity had no statistical difference.
  
  
  CONCLUSIONS
  Telbivudine treatment has efficacy and safety on MTCT interruption during late pregnancy. In addition, we demonstrated benefit of telbivudine for mothers in terms of HBV DNA negative conversion and ALT normalization. Telbivudine treatment at the end of pregnancy should be considered in women with high viral load.
authors.affiliation: Department of Infectious Diseases, Institute of Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
authors.forename: Min-Hui
authors.initials: MH
authors.lastname: Liu
authors.forename: Yun-Jian
authors.initials: YJ
authors.lastname: Sheng
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Liu
authors.forename: Huai-Dong
authors.initials: HD
authors.lastname: Hu
authors.forename: Qiong-Fang
authors.initials: QF
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Ren
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D015233:Models, Statistical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D000077712:Telbivudine; D013936:Thymidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000077712:Telbivudine; D013936:Thymidine
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