title: Transoral laser microsurgery for early glottic cancer as one-stage single-modality therapy.
abstract: OBJECTIVE
  A study was undertaken to determine the oncologic outcomes in a consecutive series of early glottic carcinomas treated with transoral CO₂ laser microsurgery (TLM) as a one-stage single-modality therapy, without any postoperative radiation therapy or retreatment with laser. We further evaluated correlations between the oncologic outcomes and clinicopathologic factors including tumor location and surgical margin.
  
  
  METHODS
  Retrospective analysis of medical records.
  
  
  METHODS
  The medical records of 118 consecutive patients with early stage (T1, T2) glottic carcinoma who underwent TLM by a single surgeon as an initial treatment from 1997 to 2011 were retrospectively reviewed. The oncologic outcomes were evaluated, and correlations to clinicopathologic factors were analyzed.
  
  
  RESULTS
  The 5-year disease-free survival, ultimate local control with laser alone, disease-specific survival, overall survival, and organ preservation rates were 87.9%, 94.2%, 99.0%, 92.2%, and 96.2%, respectively. Neither the reported surgical margin nor the extension of tumor to the anterior commissure, arytenoid, subglottis, and ventricle showed any significant impact on local control or survival.
  
  
  CONCLUSIONS
  Transoral CO₂ laser microsurgery as one-stage single-modality therapy resulted in a high rate of local control and a high survival rate in selected cases of early glottic carcinoma, regardless of the location of tumor and histopathology report on the surgical margin.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea.
authors.forename: Hyoung Shin
authors.initials: HS
authors.lastname: Lee
authors.forename: Bong-Gwon
authors.initials: BG
authors.lastname: Chun
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Kim
authors.forename: Seung Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Oh
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Hong
authors.forename: Kang Dae
authors.initials: KD
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D005260:Female; D005931:Glottis / Q000601:surgery*; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009055:Mouth; D009367:Neoplasm Staging; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: Laryngeal carcinoma; carbon dioxide laser; glottis; laryngoscopic surgery; squamous cell carcinoma