title: Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid.
abstract: We report here the self-assembly of reversible pH intelligent aggregate from natural polysaccharide hyaluronic acid and functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH). Various forms such as micelles, sacs and membranes were self-assembled through different procedures in this organic/inorganic hybrid system. The complex can be manipulated simply by changing pH to produce hydrogen-bond and ionic interaction. Furthermore the aggregates can form at a wide pH range by adjusting the proportion of the two constituents. These pH-responsive composites will offer potential opportunities in many fields, including cell immune barriers, drug and gene delivery systems and chemical sensors.
authors.affiliation: Department of Materials Science and Engineering, Jinan University, Guangzhou 510630, China. tlulu@jnu.edu.cn
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.forename: Chaowen
authors.initials: C
authors.lastname: Zhang
authors.forename: Lihua
authors.initials: L
authors.lastname: Li
authors.forename: Changren
authors.initials: C
authors.lastname: Zhou
mesh_terms: D006820:Hyaluronic Acid / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D009391:Nephelometry and Turbidimetry; D017646:Organosilicon Compounds / Q000737:chemistry*; D010316:Particle Size
chemical_list: D008823:Micelles; D017646:Organosilicon Compounds; D006820:Hyaluronic Acid