title: Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in mice.
abstract: OBJECTIVE
  Recent studies have demonstrated the therapeutic effects of bone marrow-derived cells in tissue regeneration. The aim of this study was to investigate the effects of bone marrow mononuclear cell (BMMC) transplantation in a mouse model of acute renal failure (ARF) induced by mercuric chloride.
  
  
  METHODS
  BMMC was isolated from male BALB/c mice and injected into female mice treated with a lethal dose (LD90) of mercuric chloride. Survival rate, histopathological analysis, and assessment of urea, creatinine, sodium, potassium, and mercury levels were carried out.
  
  
  RESULTS
  Cellular therapy with BMMC significantly reduced the mortality induced by mercuric chloride (p < 0.05). This finding correlated with a decrease in serum levels of urea (p = 0.04) and potassium (p < 0.01). However, no differences in renal morphology were observed when BMMC-treated and control group were compared.
  
  
  CONCLUSIONS
  Transplanted BMMC improve renal function and reduce mortality and, therefore, may represent a new therapeutic alternative to treat ARF.
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão 121, Candeal, Salvador, BA, Brazil.
authors.forename: Franciane Santos
authors.initials: FS
authors.lastname: Marques
authors.forename: Joselli Santos
authors.initials: JS
authors.lastname: Silva
authors.forename: Ricardo David
authors.initials: RD
authors.lastname: Couto
authors.forename: Elton Pereira de Sá
authors.initials: EP
authors.lastname: Barreto
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ribeiro-dos-Santos
authors.forename: Washington Luis Conrado
authors.initials: WL
authors.lastname: dos Santos
authors.forename: Milena Botelho Pereira
authors.initials: MB
authors.lastname: Soares
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000628:therapy*; D000818:Animals; D016026:Bone Marrow Transplantation; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008627:Mercuric Chloride; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000637:transplantation*
chemical_list: D008627:Mercuric Chloride