title: Role of Wnt1 and Fzd1 in the spinal cord pathogenesis of amyotrophic lateral sclerosis-transgenic mice.
abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by chronic progressive degeneration of motor neurons resulting in muscular atrophy, paralysis, and ultimately death. We have investigated the expression of Wnt1 and Fzd1 in the spinal cords of SOD1G93A ALS transgenic mice, SOD1G93A-transfected N2a cells, and primary cultured astrocytes from SOD1G93A transgenic mice. In addition, we provided further insight into the role of Wnt1 and Fzd1 in the pathogenesis of ALS transgenic mice and discuss the mechanisms underlying the Wnt signal pathway which may be useful in the treatment of ALS. The results indicate the involvement of Wnt1 and Fzd1 in the pathogenesis and development of ALS.
authors.affiliation: Department of Histology and Embryology, Weifang Medical University, Weifang, Shandong, People's Republic China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Wang
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Guan
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Li
authors.forename: Caixia
authors.initials: C
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.forename: Fenghua
authors.initials: F
authors.lastname: Zhou
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology*; D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D051157:Frizzled Receptors / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling; D051379:Mice; D008822:Mice, Transgenic; D013116:Spinal Cord / Q000473:pathology*; D051155:Wnt1 Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D051157:Frizzled Receptors; C489739:Fzd1 protein, mouse; D051155:Wnt1 Protein; C495246:Wnt1 protein, mouse