title: Lipodystrophy and inflammation predict later grip strength in HIV-infected men: the MACS Body Composition substudy.
abstract: Body fat changes in HIV-infected persons are associated with increased systemic inflammation and increased mortality. It is unknown whether lipodystrophy is also associated with declines in physical function. Between 2001 and 2003, 33 HIV-infected men with evidence of lipodystrophy (LIPO⁺), 23 HIV-infected men without lipodystrophy (LIPO⁻), and 33 seronegative men were recruited from the Multicenter AIDS Cohort Study (MACS) for the Body Composition substudy. Visceral adipose tissue (VAT) was assessed by quantitative computed tomography. Lean body mass (LBM) and extremity fat were measured by dual-energy x-ray absorptiometry. Insulin resistance was estimated by Homeostatic Model Assessment (HOMA). Serum interleukin (IL)-6, soluble tumor necrosis factor (TNF)-α receptors I and II (sTNFRI and sTNFRII), and highly sensitive C-reactive protein (hs-CRP) concentrations were quantified from archived serum samples. These measurements were correlated with grip strength measured in 2007 using linear regression. At the substudy visit, the LIPO⁺ group had higher HOMA, sTNFRI, sTNFRII, and IL-6 levels than the LIPO⁻ group. In 2007, the LIPO⁺ group had lower median grip strength than the LIPO⁻ group (34.4 vs. 42.7 kg, p=0.002). Multivariable analysis of HIV⁺ men showed older age, lower LBM, higher sTNFRII concentrations, and LIPO⁺ status [adjusted mean difference -4.9 kg (p=0.045)] at the substudy visit were independently associated with lower subsequent grip strength. Inflammation, lower LBM, and lipodystrophy in HIV-infected men were associated with lower subsequent grip strength. These findings suggest that inflammation may contribute to declines in functional performance, independent of age.
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Keith W
authors.initials: KW
authors.lastname: Crawford
authors.forename: Xiuhong
authors.initials: X
authors.lastname: Li
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Xu
authors.forename: Alison G
authors.initials: AG
authors.lastname: Abraham
authors.forename: Adrian S
authors.initials: AS
authors.lastname: Dobs
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Margolick
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Palella
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Kingsley
authors.forename: Mallory D
authors.initials: MD
authors.lastname: Witt
authors.forename: Todd T
authors.initials: TT
authors.lastname: Brown
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D002097:C-Reactive Protein / Q000032:analysis; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D018737:Hand Strength; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008060:Lipodystrophy / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D018124:Receptors, Tumor Necrosis Factor; D002097:C-Reactive Protein
references.citation: Phys Ther. 2008 Nov;88(11):1355-64
references.pmid: 18801854
references.citation: J Endocrinol Invest. 2005;28(11 Suppl Proceedings):15-9
references.pmid: 16760619
references.citation: Clin Infect Dis. 2008 Aug 15;47(4):542-53
references.pmid: 18627268
references.citation: J Infect. 2009 Nov;59(5):346-52
references.pmid: 19706308
references.citation: J Clin Endocrinol Metab. 2005 Dec;90(12):6403-9
references.pmid: 16174720
references.citation: J Gerontol A Biol Sci Med Sci. 2006 Jan;61(1):72-7
references.pmid: 16456196
references.citation: J Gerontol A Biol Sci Med Sci. 2009 May;64(5):581-9
references.pmid: 19228783
references.citation: J Endocrinol. 2010 Jun;205(3):201-10
references.pmid: 20197302
references.citation: Int J Cardiol. 2006 May 10;109(2):179-87
references.pmid: 16024109
references.citation: J Acquir Immune Defic Syndr. 2010 Nov;55(3):316-22
references.pmid: 20581689
references.citation: Sports Med. 2004;34(12):809-24
references.pmid: 15462613
references.citation: J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):356-62
references.pmid: 16980910
references.citation: Diabetologia. 1985 Jul;28(7):412-9
references.pmid: 3899825
references.citation: Am J Physiol Regul Integr Comp Physiol. 2010 Jun;298(6):R1485-95
references.pmid: 20393160
references.citation: J Gerontol A Biol Sci Med Sci. 2007 Nov;62(11):1279-86
references.pmid: 18000149
references.citation: J Womens Health (Larchmt). 2009 Dec;18(12):1965-74
references.pmid: 20044858
references.citation: AIDS Res Ther. 2009 May 13;6:8
references.pmid: 19439092
references.citation: Menopause. 2009 Nov-Dec;16(6):1093-101
references.pmid: 19512949
references.citation: Am J Epidemiol. 2007 Mar 15;165(6):696-703
references.pmid: 17194749
references.citation: J Appl Physiol (1985). 2007 Mar;102(3):919-25
references.pmid: 17095641
references.citation: HIV Med. 2003 Jul;4(3):293-301
references.pmid: 12859330
references.citation: J Geriatr Phys Ther. 2007;30(1):28-30
references.pmid: 19839178
references.citation: Am J Epidemiol. 2002 Jul 15;156(2):110-21
references.pmid: 12117699
references.citation: J Gerontol A Biol Sci Med Sci. 2009 Apr;64(4):455-61
references.pmid: 19196644
references.citation: Ann Intern Med. 2002 Sep 3;137(5 Pt 2):381-433
references.pmid: 12617573
references.citation: J Acquir Immune Defic Syndr. 2010 Jan;53(1):124-30
references.pmid: 19730109
references.citation: AIDS Rev. 2008 Jul-Sep;10(3):152-61
references.pmid: 18820717
references.citation: Osteoporos Int. 2010 May;21(5):773-84
references.pmid: 19597907
references.citation: Stat Med. 1996 Feb 28;15(4):361-87
references.pmid: 8668867
references.citation: J Gerontol A Biol Sci Med Sci. 2005 Oct;60(10):1278-82
references.pmid: 16282559
references.citation: JPEN J Parenter Enteral Nutr. 2008 Nov-Dec;32(6):656-9
references.pmid: 18974248
references.citation: Ann Nutr Metab. 2007;51(1):35-41
references.pmid: 17356264
references.citation: Arch Gerontol Geriatr. 2009 Jul-Aug;49(1):22-6
references.pmid: 18513808
references.citation: J Periodontol. 2008 Aug;79(8 Suppl):1544-51
references.pmid: 18673009
references.citation: J Clin Endocrinol Metab. 2005 Mar;90(3):1502-10
references.pmid: 15572415
references.citation: J Acquir Immune Defic Syndr. 2000 Dec 1;25(4):312-21
references.pmid: 11114831
references.citation: Osteoporos Int. 2005 Dec;16(12):1525-37
references.pmid: 15889316
references.citation: Atherosclerosis. 2010 Jan;208(1):222-7
references.pmid: 19595354
references.citation: Curr HIV/AIDS Rep. 2011 Sep;8(3):133-41
references.pmid: 21647555
references.citation: Rejuvenation Res. 2010 Feb;13(1):3-11
references.pmid: 20230273
references.citation: Obesity (Silver Spring). 2009 Jan;17(1):53-9
references.pmid: 19008869
references.citation: J Clin Endocrinol Metab. 2008 Nov;93(11 Suppl 1):S57-63
references.pmid: 18987271
references.citation: Ann Intern Med. 2007 Jan 16;146(2):87-95
references.pmid: 17227932
references.citation: Top HIV Med. 2009 Sep-Oct;17(4):118-23
references.pmid: 19890183
references.citation: Clin Infect Dis. 2004 Mar 15;38(6):903-7
references.pmid: 14999638
references.citation: Int J Epidemiol. 2007 Feb;36(1):228-35
references.pmid: 17056604
references.citation: J Gerontol A Biol Sci Med Sci. 2010 Jun;65(6):658-63
references.pmid: 20421241
references.citation: Curr HIV/AIDS Rep. 2010 Feb;7(1):4-10
references.pmid: 20425052
references.citation: BMC Res Notes. 2011 Apr 14;4:127
references.pmid: 21492469
references.citation: J Clin Densitom. 2010 Jan-Mar;13(1):96-101
references.pmid: 20171571
references.citation: J Clin Endocrinol Metab. 2005 Jan;90(1):32-8
references.pmid: 15483073
references.citation: J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1183-9
references.pmid: 19622801