title: Differential dose response of mTOR signaling to oral administration of leucine in skeletal muscle and liver of rats.
abstract: Phosphorylation of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1) in the rat liver increased in proportion to the amount of leucine administered, ranging from 0.169 to 1.35 g/kg of body weight. In the skeletal muscle, phosphorylation of these factors reached a plateau at 0.675 g/kg of body weight. The sensitivity of mammalian target of rapamycin (mTOR) signaling to leucine in the skeletal muscle appeared to be higher than that in the liver.
authors.affiliation: Department of Bioproductive Science, Utsunomiya University, Tochigi, Japan. fumiaki@cc.utsunomiya-u.ac.jp
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Yoshizawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Mochizuki
authors.forename: Kunio
authors.initials: K
authors.lastname: Sugahara
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007930:Leucine / Q000008:administration & dosage* / Q000494:pharmacology*; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008297:Male; D018482:Muscle, Skeletal / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D058570:TOR Serine-Threonine Kinases; D007930:Leucine