title: Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats.
abstract: In the present study, the beneficial effect of hesperidin (HP), a citrus flavonoid, on cisplatin (CP)-induced neurotoxicity was investigated. A total of 28 rats were equally divided into four groups; the first group was kept as control. In the second and third groups, CP and HP were given at the doses of 7 and 50 mg/kg/day, respectively. In the fourth group, CP and HP were given together at the same doses. The results indicated that although CP caused significant induction of lipid peroxidations and reduction in the antioxidant defense system potency in the brain and sciatic nerve, HP prevented these effects of CP. Besides, CP led to histopathological damage, mainly apoptosis, as well as electromyographical (EMG) changes in sciatic nerve. On the other hand, HP treatment reversed histopathological and EMG effects of CP. In conclusion, CP had severe dose-limiting neurotoxic effects and these effects of CP can be prevented by HP treatment. Thus, it appears that coadministration of HP with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Inonu, Malatya, Turkey.
authors.forename: Suat
authors.initials: S
authors.lastname: Kamisli
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Inonu, Malatya, Turkey osmciftci@gmail.com.
authors.forename: Osman
authors.initials: O
authors.lastname: Ciftci
authors.affiliation: Department of Medical Biochemistry, Graduate Institute of Health Sciences, University of Inonu, Malatya, Turkey.
authors.forename: Kursat
authors.initials: K
authors.lastname: Kaya
authors.affiliation: Department of Histology and Embryology, Faculty Medicine, University of Inonu, Malatya, Turkey.
authors.forename: Asli
authors.initials: A
authors.lastname: Cetin
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Inonu, Malatya, Turkey.
authors.forename: Ozden
authors.initials: O
authors.lastname: Kamisli
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Inonu, Malatya, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Ozcan
mesh_terms: D000818:Animals; D000975:Antioxidants; D017209:Apoptosis / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002945:Cisplatin / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006569:Hesperidin / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D017392:Thiobarbituric Acid Reactive Substances; D006569:Hesperidin; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002945:Cisplatin
keywords: Cisplatin; electromyography; hesperidin; neurotoxic effect; oxidative damage