title: Therapeutic potential of Wenshen Xiaozheng tang, a traditional Chinese medicine prescription, for treating endometriosis.
abstract: The objective of this study is to investigate the effect of Wenshen Xiaozheng Tang (WXT) on the development of endometriosis in a rat model. Sprague-Dawley rats in which endometriotic implants were induced were divided randomly into 3 groups. The rats in the low-dose and high-dose WXT groups were administered WXT 8.57 and 17.14 g/kg/d, respectively. The rats in the control groups received an equal volume of dissolvent, as did the sham-operated rats. After treatment for 4 weeks, WXT significantly decreased the mean lesion size as well as the peritoneal fluid and serum levels of tumor necrosis factor α and interleukin 1β. Cyclooxygenase-2, matrix metalloproteinase 9, plasminogen activator inhibitor 1, and intercellular adhesion molecule 1 messenger RNA (mRNA) levels were downregulated, and the mRNA expression of tissue inhibitor of metalloproteinase 1 was upregulated in the endometriotic lesions of WXT versus control group. Our data suggested that WXT may suppress the development of endometriosis by inhibiting the production of proinflammatory cytokines and regulating the expression of invasion-related genes in the endometriotic lesions.
authors.affiliation: 1Laboratory of Gynecological Oncology, The Hospital on Integration of Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, PR China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Chunping
authors.initials: C
authors.lastname: Hu
authors.forename: Weiwei
authors.initials: W
authors.lastname: Tang
authors.forename: Tao
authors.initials: T
authors.lastname: Gui
authors.forename: Ruyun
authors.initials: R
authors.lastname: Qian
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Xing
authors.forename: Peng
authors.initials: P
authors.lastname: Cao
authors.forename: Guiping
authors.initials: G
authors.lastname: Wan
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D008516:Medicine, Chinese Traditional / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Wenshen Xiaozheng Tang; endometriosis; inflammation; invasion