title: Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease.
abstract: Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22(phox) mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small-molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity.
authors.affiliation: Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA. gorin@uthscsa.edu
authors.forename: Yves
authors.initials: Y
authors.lastname: Gorin
mesh_terms: D000818:Animals; D003408:Cresols / Q000633:toxicity*; D004847:Epithelial Cells / Q000187:drug effects*; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000187:drug effects*; D008297:Male; D019255:NADPH Oxidases / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D051436:Renal Insufficiency, Chronic / Q000139:chemically induced*; D013463:Sulfuric Acid Esters / Q000633:toxicity*
chemical_list: D003408:Cresols; D013463:Sulfuric Acid Esters; C408690:4-cresol sulfate; D019255:NADPH Oxidases
references.citation: J Ren Nutr. 2010 Sep;20(5 Suppl):S2-6
references.pmid: 20797565
references.citation: Free Radic Biol Med. 2012 Jul 15;53(2):289-96
references.pmid: 22618020
references.citation: Circ Res. 2012 May 11;110(10):1364-90
references.pmid: 22581922
references.citation: Nephrol Dial Transplant. 2011 May;26(5):1464-7
references.pmid: 21406546
references.citation: J Med Chem. 2010 Nov 11;53(21):7715-30
references.pmid: 20942471
references.citation: Nephrol Dial Transplant. 2010 Apr;25(4):1183-91
references.pmid: 19914995
references.citation: Kidney Int. 2013 Apr;83(4):582-92
references.pmid: 23325087
references.citation: Clin Sci (Lond). 2013 Feb;124(3):191-202
references.pmid: 22920224
references.citation: Pediatr Nephrol. 2008 Aug;23(8):1211-21
references.pmid: 18324423
references.citation: Kidney Int. 2011 May;79(9):944-56
references.pmid: 21307839