title: Brain-targeted polymeric nanoparticles: in vivo evidence of different routes of administration in rodents.
abstract: AIMS, MATERIALS & METHODS: The capacity of polymeric nanoparticles (NPs) to reach the target regardless of the administration route is a neglected field of investigation in pharmaceutical nanotechnology. Therefore, after having demonstrated in previous studies that glycopeptide-engineered NPs (g7-NPs) were able to reach the brain after intravenous administrations in rodents, this article aims to evaluate whether they can reach the CNS when administered by different routes.
  
  
  CONCLUSIONS
  The confocal microphotographs on murine brain sections showed the capability of g7-NPs to reach the target also after intraperitoneal, intranasal and oral administrations. This could open new vistas for the future application of g7-NPs in the therapeutic treatment of CNS diseases.
authors.affiliation: Department of Life Sciences, University of Modena & Reggio Emilia, Via Campi 183, 41125, Modena, Italy. gtosi@unimore.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tosi
authors.forename: Barbara
authors.initials: B
authors.lastname: Ruozi
authors.forename: Daniela
authors.initials: D
authors.lastname: Belletti
authors.forename: Antonietta
authors.initials: A
authors.lastname: Vilella
authors.forename: Michele
authors.initials: M
authors.lastname: Zoli
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Vandelli
authors.forename: Flavio
authors.initials: F
authors.lastname: Forni
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002490:Central Nervous System / Q000187:drug effects* / Q000473:pathology; D004333:Drug Administration Routes; D006020:Glycopeptides / Q000008:administration & dosage*; D006801:Humans; D051379:Mice; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000008:administration & dosage*; D011108:Polymers / Q000008:administration & dosage*; D051381:Rats; D014018:Tissue Distribution
chemical_list: D006020:Glycopeptides; D011108:Polymers