title: Plasmonic imaging of brownian motion of single DNA molecules spontaneously binding to Ag nanoparticles.
abstract: We find the spontaneous binding of single DNA molecules to uncoated silver nanoparticles (AgNPs) in aqueous solution with Mn(2+) (3 mM). From dark-field optical microscopic imaging of AgNPs bound to DNA molecules, we demonstrate analysis of the Brownian motion of single DNA molecules via plasmon resonance elastic light scattering. Our results provide that the plasmonic imaging technique is free from photobleaching and blinking and thus is useful in long-time observations of single-molecule DNA dynamics.
authors.affiliation: Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan. hirano-ken@aist.go.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Hirano
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ishido
authors.forename: Yuko S
authors.initials: YS
authors.lastname: Yamamoto
authors.forename: Norio
authors.initials: N
authors.lastname: Murase
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ichikawa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Baba
authors.forename: Tamitake
authors.initials: T
authors.lastname: Itoh
mesh_terms: D004247:DNA / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D012996:Solutions; D020349:Surface Plasmon Resonance; D014867:Water / Q000737:chemistry
chemical_list: D012996:Solutions; D014867:Water; D012834:Silver; D008345:Manganese; D004247:DNA