title: Somatosensory abnormalities for painful and innocuous stimuli at the back and at a site distinct from the region of pain in chronic back pain patients.
abstract: Chronic low back pain (CLBP) was shown to be associated with pathophysiological changes at several levels of the sensorimotor system. Changes in sensory thresholds have been reported but complete profiles of Quantitative Sensory Testing (QST) were only rarely obtained in CLBP patients. The aim of the present study was to investigate comprehensive QST profiles in CLBP at the painful site (back) and at a site distinct from their painful region (hand) and to compare these data with similar data in healthy controls. We found increased detection thresholds in CLBP patients compared to healthy controls for all innocuous stimuli at the back and extraterritorial to the painful region at the hand. Additionally, CLBP patients showed decreased pain thresholds at both sites. Importantly, there was no interaction between the investigated site and group, i.e. thresholds were changed both at the affected body site and for the site distinct from the painful region (hand). Our results demonstrate severe, widespread changes in somatosensory sensitivity in CLBP patients. These widespread changes point to alterations at higher levels of the neuraxis or/and to a vulnerability to nociceptive plasticity in CLBP patients.
authors.affiliation: Department of Sports Medicine and Health Promotion, Friedrich Schiller University, Jena, Germany. christian.puta@uni-jena.de
authors.forename: Christian
authors.initials: C
authors.lastname: Puta
authors.forename: Birgit
authors.initials: B
authors.lastname: Schulz
authors.forename: Saskia
authors.initials: S
authors.lastname: Schoeler
authors.forename: Walter
authors.initials: W
authors.lastname: Magerl
authors.forename: Brunhild
authors.initials: B
authors.lastname: Gabriel
authors.forename: Holger H W
authors.initials: HH
authors.lastname: Gabriel
authors.forename: Wolfgang H R
authors.initials: WH
authors.lastname: Miltner
authors.forename: Thomas
authors.initials: T
authors.lastname: Weiss
mesh_terms: D016022:Case-Control Studies; D059350:Chronic Pain / Q000150:complications*; D005260:Female; D006801:Humans; D017116:Low Back Pain / Q000150:complications*; D008875:Middle Aged; D017288:Pain Threshold; D010468:Perceptual Disorders / Q000150:complications* / Q000503:physiopathology*; D010812:Physical Stimulation
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