title: Use of baclofen for withdrawal in a preterm infant.
abstract: Baclofen is a gamma-aminobutyric acid agonist used primarily as a muscle relaxant to treat spasticity in children and adults. Withdrawal of oral baclofen is known to cause a withdrawal syndrome in adults. Only one previous case describes a withdrawal syndrome in a term infant, manifested by seizures, associated with the use of oral baclofen in the mother. This case describes a withdrawal syndrome and the unique use of baclofen for withdrawal in a preterm infant.
authors.affiliation: Division of Neonatal Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA. sddunc02@louisville.edu
authors.forename: S D
authors.initials: SD
authors.lastname: Duncan
authors.forename: L A
authors.initials: LA
authors.lastname: Devlin
mesh_terms: D000328:Adult; D001418:Baclofen / Q000008:administration & dosage / Q000009:adverse effects; D002574:Cervical Vertebrae / Q000293:injuries*; D002585:Cesarean Section / Q000379:methods; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000009:adverse effects; D009357:Neonatal Abstinence Syndrome / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D010264:Paraplegia / Q000188:drug therapy / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011297:Prenatal Exposure Delayed Effects; D016103:Spinal Fractures / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen