title: Gray matter atrophy in progressive supranuclear palsy: meta-analysis of voxel-based morphometry studies.
abstract: Voxel-based morphometry (VBM) studies have provided cumulative evidence of gray matter (GM) atrophy in patients with progressive supranuclear palsy (PSP) relative to healthy controls (HC). However, not all findings have been entirely concordant. Herein, we performed a quantitative meta-analysis study in order to consistently quantify GM anomalies in PSP. We conducted a systematic search for VBM studies of PSP patients and HC using PubMed and Embase databases from January 2000 to May 2012. Meta-analysis of these VBM studies was performed using a newly improved voxel-based meta-analytic technique, effect-size signed differential mapping. A total of 9 cross-sectional VBM studies that involved 143 PSP patients and 216 HC subjects met the inclusion criteria. Considerable regional GM volume decrease was detected in the thalamus, basal ganglia, midbrain, insular cortex, and frontal cortex. These findings remained largely unchanged following jackknife sensitivity analyses. The present meta-analysis provided evidence of PSP-specific GM atrophy. This finding might help contribute to our understanding of the neurobiological basis underlying PSP.
authors.affiliation: Department of Neurology, Yancheng Third People's Hospital, The affiliated Yancheng hospital of Southeast University medical college, YanCheng, 224001 Jiangsu Province, People's Republic of China. yc3yhcshi@gmail.com
authors.forename: Hai Cun
authors.initials: HC
authors.lastname: Shi
authors.forename: Jian Guo
authors.initials: JG
authors.lastname: Zhong
authors.forename: Ping Lei
authors.initials: PL
authors.lastname: Pan
authors.forename: Pei Rong
authors.initials: PR
authors.lastname: Xiao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shen
authors.forename: Li Juan
authors.initials: LJ
authors.lastname: Wu
authors.forename: Hua Liang
authors.initials: HL
authors.lastname: Li
authors.forename: Yuan Ying
authors.initials: YY
authors.lastname: Song
authors.forename: Gui Xiang
authors.initials: GX
authors.lastname: He
authors.forename: Hong Ye
authors.initials: HY
authors.lastname: Li
mesh_terms: D000818:Animals; D001284:Atrophy / Q000175:diagnosis / Q000453:epidemiology; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000473:pathology*; D002986:Clinical Trials as Topic / Q000379:methods; D006801:Humans; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*
references.citation: Acta Neuropathol. 1996 Dec;92(6):640-4
references.pmid: 8960325
references.citation: Mov Disord. 2003 May;18(5):467-86
references.pmid: 12722160
references.citation: Neurology. 1994 Nov;44(11):2015-9
references.pmid: 7969952
references.citation: Eur J Neurol. 2012 Feb;19(2):199-206
references.pmid: 21762435
references.citation: J Neurol. 1992 Feb;239(2):98-102
references.pmid: 1552311
references.citation: Neurobiol Aging. 2012 Aug;33(8):1833-8
references.pmid: 21621298
references.citation: Acta Neurol Scand. 2004 Aug;110(2):128-35
references.pmid: 15242422
references.citation: Neurology. 2011 Jul 12;77(2):101-9
references.pmid: 21613601
references.citation: J Neurol. 2010 Jan;257(1):5-14
references.pmid: 19669613
references.citation: Ann Neurol. 1989 Feb;25(2):131-9
references.pmid: 2784043
references.citation: J Neurol Neurosurg Psychiatry. 2004 Feb;75(2):246-9
references.pmid: 14742598
references.citation: Brain Pathol. 2007 Jan;17(1):74-82
references.pmid: 17493041
references.citation: Neurology. 1996 Jul;47(1):1-9
references.pmid: 8710059
references.citation: Childs Nerv Syst. 2002 Aug;18(8):386-404
references.pmid: 12192499
references.citation: Neuroimage. 2000 Jun;11(6 Pt 1):805-21
references.pmid: 10860804
references.citation: Arch Neurol. 1964 Apr;10:333-59
references.pmid: 14107684
references.citation: Mov Disord. 2003 Sep;18(9):1018-26
references.pmid: 14502669
references.citation: Brain. 2002 May;125(Pt 5):969-75
references.pmid: 11960887
references.citation: Neurosci Biobehav Rev. 2012 Feb;36(2):757-63
references.pmid: 22192882
references.citation: Brain. 2005 Jun;128(Pt 6):1247-58
references.pmid: 15788542
references.citation: Arq Neuropsiquiatr. 2010 Dec;68(6):938-46
references.pmid: 21243256
references.citation: Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):381-92
references.pmid: 22187545
references.citation: Mov Disord. 2010 Oct 30;25(14):2395-404
references.pmid: 20669302
references.citation: Arch Neurol. 2006 Jan;63(1):81-6
references.pmid: 16401739
references.citation: Neurology. 1998 Jun;50(6):1637-47
references.pmid: 9633705
references.citation: Ann Neurol. 1999 Jan;45(1):65-74
references.pmid: 9894879
references.citation: Neuroradiology. 2012 Jul;54(7):771-80
references.pmid: 22160214
references.citation: Brain. 2012 Jul;135(Pt 7):2089-102
references.pmid: 22637582
references.citation: Neuroimage. 2004 Oct;23(2):663-9
references.pmid: 15488416
references.citation: Br J Psychiatry. 2009 Nov;195(5):393-402
references.pmid: 19880927
references.citation: Brain. 2010 Aug;133(Pt 8):2410-25
references.pmid: 20826434
references.citation: Lancet Neurol. 2009 Mar;8(3):270-9
references.pmid: 19233037
references.citation: Eur Psychiatry. 2012 Nov;27(8):605-11
references.pmid: 21658917
references.citation: Neuroradiology. 2001 Jul;43(7):542-6
references.pmid: 11512582
references.citation: Mov Disord. 2012 Jan;27(1):151-5
references.pmid: 22359740
references.citation: Parkinsonism Relat Disord. 2011 Sep;17(8):599-605
references.pmid: 21665514
references.citation: Eur J Neurosci. 2010 Aug;32(4):640-7
references.pmid: 20597976
references.citation: Dement Geriatr Cogn Disord. 2012;33(2-3):141-8
references.pmid: 22722668
references.citation: Behav Brain Res. 2011 Nov 20;225(1):341-7
references.pmid: 21729721
references.citation: Arch Gen Psychiatry. 2011 Apr;68(4):409-18
references.pmid: 21464365
references.citation: Biol Psychiatry. 2010 Jun 1;67(11):1097-105
references.pmid: 20303066
references.citation: Neurosci Lett. 2005 Jul 22-29;383(1-2):22-7
references.pmid: 15936506
references.citation: Lancet Neurol. 2002 Oct;1(6):359-69
references.pmid: 12849397
references.citation: Brain Res Brain Res Rev. 1996 Oct;22(3):229-44
references.pmid: 8957561
references.citation: Brain. 2005 Jun;128(Pt 6):1259-66
references.pmid: 15843423
references.citation: J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):457-63
references.pmid: 16306152
references.citation: Parkinsonism Relat Disord. 2011 Mar;17(3):172-6
references.pmid: 21236720
references.citation: Brain. 2005 Feb;128(Pt 2):239-49
references.pmid: 15649952
references.citation: Ann Neurol. 1988 Sep;24(3):399-406
references.pmid: 3265862
references.citation: J Neurol Sci. 2002 Jul 15;199(1-2):67-71
references.pmid: 12084445