title: Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases.
abstract: Leptin is an adipocyte-derived hormone, recognized as a critical mediator of the balance between food intake and energy expenditure by signalling through its functional receptor (Ob-Rb) in the hypothalamus. Structurally, leptin belongs to the long-chain helical cytokine family, and is now known to have pleiotropic functions in both innate and adaptive immunity. The presence of the functional leptin receptor in the lung together with evidence of increased airspace leptin levels arising during pulmonary inflammation, suggests an important role for leptin in lung development, respiratory immune responses and eventually pathogenesis of inflammatory respiratory diseases. The purpose of this article is to review our current understanding of leptin and its functional role on the different resident cell types of the lung in health as well as in the context of three major respiratory conditions being chronic obstructive pulmonary disease (COPD), asthma, and pneumonia.
authors.affiliation: Department of Respiratory Medicine, Maastricht University Medical Center+, PO Box 5800, 6202 AZ Maastricht, The Netherlands. j.vernooy@maastrichtuniversity.nl
authors.forename: Juanita H J
authors.initials: JH
authors.lastname: Vernooy
authors.forename: Niki D J
authors.initials: ND
authors.lastname: Ubags
authors.forename: Guy G
authors.initials: GG
authors.lastname: Brusselle
authors.forename: Jan
authors.initials: J
authors.lastname: Tavernier
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Suratt
authors.forename: Guy F
authors.initials: GF
authors.lastname: Joos
authors.forename: Emiel F M
authors.initials: EF
authors.lastname: Wouters
authors.forename: Ken R
authors.initials: KR
authors.lastname: Bracke
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D020738:Leptin / Q000276:immunology* / Q000378:metabolism; D008168:Lung / Q000276:immunology / Q000502:physiology / Q000503:physiopathology; D011014:Pneumonia / Q000276:immunology* / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology* / Q000503:physiopathology
chemical_list: D020738:Leptin
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