title: The relationship of NT-proBNP and dialysis parameters with outcome of incident haemodialysis patients: results from the membrane permeability outcome study.
abstract: OBJECTIVE
  The association of raised levels of natriuretic peptides with elevated risk of mortality was investigated in the present analysis of the Membrane Permeability Outcome study.
  
  
  METHODS
  N-terminal probrain type natriuretic peptide (NT-proBNP) was measured in 618 incident haemodialysis patients, randomised to either high-flux or low-flux. Characteristics of patients with NT-proBNP levels below or above the median were descriptively analysed and survival analysis was performed.
  
  
  RESULTS
  Median NT-proBNP value was 2,124 pg/ml, with 1,854 pg/ml in the high-flux and 2,919 pg/ml in the low-flux group. Survival probability was lowest in patients with both a history of cardiovascular disease and NT-proBNP values above the median (p < 0.001). A multivariate Cox proportional hazard model showed interaction between presence of cardiovascular diseases and NT-proBNP levels above the median.
  
  
  CONCLUSIONS
  NT-proBNP is an independent predictor of mortality also in incident haemodialysis patients. Lower concentrations associated with high-flux dialysis suggest a possible biological link to improved survival in this group.
authors.affiliation: Department of Nephrology, Dialysis and Renal Transplantation, A. Manzoni Hospital, Lecco, Italy. f.locatelli @ ospedale.lecco.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Locatelli
authors.forename: Thierry
authors.initials: T
authors.lastname: Hannedouche
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martin-Malo
authors.forename: Stefan H
authors.initials: SH
authors.lastname: Jacobson
authors.forename: Raymond
authors.initials: R
authors.lastname: Vanholder
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
authors.forename: Vincenzo
authors.initials: V
authors.lastname: La Milia
authors.forename: Juan M
authors.initials: JM
authors.lastname: Lopez Gomez
authors.forename: Sergio
authors.initials: S
authors.lastname: Stefoni
authors.forename: Hervé
authors.initials: H
authors.lastname: Maheut
authors.forename: Marian
authors.initials: M
authors.lastname: Klinger
authors.forename: Thierry
authors.initials: T
authors.lastname: Krummel
authors.forename: Annemie
authors.initials: A
authors.lastname: Dhondt
authors.forename: Isabel
authors.initials: I
authors.lastname: Berdud
authors.forename: Adelheid
authors.initials: A
authors.lastname: Gauly
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010539:Permeability; D016016:Proportional Hazards Models; D011446:Prospective Studies; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000628:therapy; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D008567:Membranes, Artificial; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain