title: In vivo monitoring of distributional transport kinetics and extravasation of quantum dots in living rat liver.
abstract: Although the unique optical properties of surface-modified quantum dots (QDs) have attracted wide interest in molecular biology and bioengineering, there are very few reports of their in vivo biodistribution, due to a lack of analytical techniques for characterizing the dynamic variation of QDs in living animals. In this study, we used an in vivo online monitoring system and a batch-wise elemental analytical method to investigate the biodistribution/extravasation of various surface-modified CdTeSe/ZnS (QDs) in rat liver. It is found that the surface modification dictated not only the blood retention profile but also the degree of extravasation and the clearance of extracellular QDs, making it an important variable for regulating the transfer and exchange process of QDs among three physiological compartments-bloodstream, extracellular space and Kupffer cells/hepatocytes.
authors.affiliation: Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu, 30013, Taiwan.
authors.forename: Cheng-Kuan
authors.initials: CK
authors.lastname: Su
authors.forename: Yuh-Chang
authors.initials: YC
authors.lastname: Sun
mesh_terms: D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry / Q000494:pharmacology; D004867:Equipment Design; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D013058:Mass Spectrometry / Q000295:instrumentation; D010477:Perfusion / Q000295:instrumentation; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics; D045663:Quantum Dots; D051381:Rats; D012643:Selenium / Q000737:chemistry / Q000493:pharmacokinetics; D052616:Solid Phase Extraction / Q000295:instrumentation; D013440:Sulfides / Q000737:chemistry / Q000493:pharmacokinetics; D013691:Tellurium / Q000737:chemistry / Q000494:pharmacology; D014018:Tissue Distribution; D017967:Zinc Compounds / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D019187:Cadmium Compounds; D013440:Sulfides; D017967:Zinc Compounds; D011092:Polyethylene Glycols; D012643:Selenium; C031238:zinc sulfide; D013691:Tellurium; C028337:cadmium telluride