title: Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion.
abstract: OBJECTIVE
  Data on the optimal head position for patients with acute ischemic stroke are unavailable. We evaluated the effects of mild head-down tilt (HDT) on cerebral blood flow (CBF) in mice during bilateral common carotid artery occlusion (BCCAO).
  
  
  METHODS
  We used mice with BCCAO (35 minutes) and divided these into 2 groups ( n=16): BCCAO at 0°-HDT and 5°-HDT. CBF was measured for both hemispheres with a non-invasive laser Doppler blood perfusion imager. Changes in CBF during BCCAO were examined in both groups.
  
  
  RESULTS
  A significantly greater increase in CBF in both hemispheres was observed in 5°-HDT mice than in 0°-HDT mice (126.1% (8.715)% vs. 102.1% (4.718)%; P=0.0294).
  
  
  CONCLUSIONS
  HDT enhanced the increase in CBF in both hemispheres in the mouse BCCAO model. The potential mechanism underlying CBF increase enhanced by HDT during BCCAO warrants further investigation.
authors.affiliation: Department of Neurosurgery, National Defense Medical College, Saitama, Japan.
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Nagatani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nawashiro
authors.forename: Satoru
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Naoki
authors.initials: N
authors.lastname: Otani
authors.forename: Kojiro
authors.initials: K
authors.lastname: Wada
authors.forename: Katsuji
authors.initials: K
authors.lastname: Shima
keywords: Bilateral common carotid artery occlusion; brain infarction; cerebral blood flow; head down; mouse
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