title: Use of preoperative clinicopathologic characteristics to identify patients with low-risk cervical cancer suitable for Piver class II radical hysterectomy.
abstract: OBJECTIVE
  To investigate the long-term efficacy of Piver-Rutledge class II radical hysterectomy (Piver II RH) for treatment of early-stage cervical cancer and to identify suitable candidates for this procedure.
  
  
  METHODS
  A retrospective study was conducted of 432 cervical cancer patients (tumor size ≤4 cm) treated with Piver II RH at Sun Yat-sen University Cancer Center, Guangzhou, China, between January 1, 1999, and June 30, 2005. The correlation of preoperative and postoperative characteristics with recurrence and survival was analyzed.
  
  
  RESULTS
  Median follow-up was 72 months; the overall recurrence rate was 14.6%. The 5-year recurrence-free survival (RFS) was 88.0% and the 5-year overall survival (OS) was 93.0%. Significant differences were observed between patients with small (≤2 cm) and large (>2 cm) tumors with regard to intra-pelvic recurrence (2.5% vs 13.4%; P=0.001), extra-pelvic recurrence (3.4% vs 9.9%; P=0.028), RFS (95.0% vs 86.0%; P=0.005), and OS (95.0% vs 87.0%; P=0.005). Preoperative tumor size was the only factor that correlated with recurrence (P=0.018), RFS (P=0.038), and OS (P=0.029) in a multivariate analysis.
  
  
  CONCLUSIONS
  Cervical cancer patients with tumors of 2 cm or less were identified as candidates for Piver II RH, which promoted excellent local tumor control and long-term survival.
authors.affiliation: Department of Gynecology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China. xyxy0203@yahoo.com
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiong
authors.forename: Ji-hong
authors.initials: JH
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Zheng
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Cao
authors.forename: Li-zhi
authors.initials: LZ
authors.lastname: Liang
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D057234:Preoperative Period; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*