title: Thematic minireview series: metals in biology 2013.
abstract: One-half of the available protein structures contain metals, explaining their roles as essential trace elements. Metals are also critical in many aspects of nucleic acid biochemistry. This prologue briefly introduces the fifth of the Thematic Series on Metals in Biology, which began in the Journal of Biological Chemistry in 2009. The five minireviews in this 2013 series deal with the molybdenum prosthetic group (a pterin known as Moco); the biosynthesis of the "M-cluster" molybdenum prosthetic group of nitrogenase; the biosynthesis of the nickel-based metallocenter of the enzyme urease; several of the processing, transport, and medical aspects of cobalamins; and the growing roles of heme sensor proteins.
authors.affiliation: Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA. f.guengerich@vanderbilt.edu
authors.forename: F Peter
authors.initials: FP
authors.lastname: Guengerich
mesh_terms: D000818:Animals; D001695:Biology; D006801:Humans; D008667:Metalloproteins / Q000737:chemistry / Q000502:physiology*; D012196:Review Literature as Topic; D014131:Trace Elements / Q000378:metabolism*
chemical_list: D008667:Metalloproteins; D014131:Trace Elements
keywords: Cobalamin; Heme; Metalloenzymes; Metalloproteins; Metals; Molybdenum; Nickel
references.citation: J Biol Chem. 2009 Jul 10;284(28):18557
references.pmid: 19363036
references.citation: Nature. 2010 Aug 5;466(7307):779-82
references.pmid: 20639861
references.citation: J Biol Chem. 2010 Aug 27;285(35):26727
references.pmid: 20522544
references.citation: Bioessays. 2011 May;33(5):350-7
references.pmid: 21387349
references.citation: Science. 2011 Jun 3;332(6034):1163-6
references.pmid: 21127214
references.citation: J Biol Chem. 2009 Jan 9;284(2):709
references.pmid: 18757360
references.citation: J Biol Chem. 2012 Apr 20;287(17):13508-9
references.pmid: 22389507