title: Cariotester, a new device for assessment of dentin lesion remineralization in vitro.
abstract: This study aimed to evaluate the potential of a new device (Cariotester) for monitoring of incipient carious lesion remineralization in root dentin by topical fluoride in vitro. Demineralized bovine dentin specimens were treated by fluoride solutions (APF or neutral NaF) and remineralized for 4 weeks. Cariotester was used to measure penetration depth (CTR depth) of the indenter into the de- and remineralized specimen surface. The specimens were assessed by transverse microradiography (TMR) to determine lesion parameters (depth: LD, mineral loss: ΔZ). Pearson's correlation analysis showed an overall significant relationship between CTR depth and both TMR parameters. CTR depth appeared to distinguish the positive effect that topical fluoride application had on the remineralization of the outer zone of dentin lesions. Cariotester had the potential to serve as a quantitative tool for monitoring of incipient carious lesion remineralization in root dentin.
authors.affiliation: Cariology and Operative Dentistry, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Utaka
authors.forename: Syozi
authors.initials: S
authors.lastname: Nakashima
authors.forename: Alireza
authors.initials: A
authors.lastname: Sadr
authors.forename: Masaomi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Toru
authors.initials: T
authors.lastname: Nikaido
authors.forename: Akihiko
authors.initials: A
authors.lastname: Shimizu
authors.forename: Junji
authors.initials: J
authors.lastname: Tagami
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000627:therapeutic use; D000818:Animals; D002122:Calcium Chloride / Q000627:therapeutic use; D002327:Cariostatic Agents / Q000627:therapeutic use; D002417:Cattle; D003804:Dentin / Q000187:drug effects* / Q000473:pathology; D005460:Fluorides, Topical / Q000627:therapeutic use; D006244:Hardness; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008852:Microradiography; D008903:Minerals / Q000032:analysis; D009584:Nitrogen / Q000627:therapeutic use; D010710:Phosphates / Q000627:therapeutic use; D017680:Potassium Compounds / Q000627:therapeutic use; D012965:Sodium Chloride / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D013997:Time Factors; D017001:Tooth Demineralization / Q000188:drug therapy* / Q000473:pathology; D014089:Tooth Remineralization / Q000295:instrumentation* / Q000379:methods; D014092:Tooth Root / Q000187:drug effects / Q000473:pathology
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D008903:Minerals; D010710:Phosphates; D017680:Potassium Compounds; C003320:sodium nitride; D000149:Acidulated Phosphate Fluoride; D012965:Sodium Chloride; D012969:Sodium Fluoride; C013216:potassium phosphate; D002122:Calcium Chloride; D009584:Nitrogen