title: [Association between adiponectin gene polymorphisms and obesity in school age children from Hualpén, Chile].
abstract: BACKGROUND
  Several genetic polymorphisms of adiponectin have been associated to metabolic diseases as obesity and co-morbidities.
  
  
  OBJECTIVE
  To investigate if there are associations between +45TG, +276GT, -11,377CG y -11,391GA adiponectin SNPs (single nucleotide polymorphism) with obesity in a Chilean children population.
  
  
  METHODS
  A case-control study was performed in 241 obese and 126 normal weight children (7-11 years old) from the urban community of Hualpén, Biobío region. Children were classified as normal or obese, according to age and gender-specificpercentiles defined by Centerfor Disease Control and Prevention (CDC). The analysis of serum markers was carried out using commercial kits. Adiponectin polymorphisms were determined through a High Resolution Melting (HRM)-enabled real time PCR and by DNA fragment sequencing.
  
  
  RESULTS
  The observed allelic frequencies of the studied SNPs were over 11%. The 11,377CG polymorphism was associated with a high risk of obesity, calculated by the additive inheritance model (odds ratio = 1.389, 95% confidence interval: 1.001-1.929,p = 0.049).
  
  
  CONCLUSIONS
  Obese school children of the Biobío Region, have an increased risk of carrying the susceptibility allele polymorphism 11377CG of adiponectin gene.
authors.affiliation: Departamento de Bioquímica Clínica e Inmunológica, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.
authors.forename: Gloria
authors.initials: G
authors.lastname: Orellana
authors.forename: Jorge
authors.initials: J
authors.lastname: Sapunar
authors.forename: Katia
authors.initials: K
authors.lastname: Sáez
authors.forename: Claudio
authors.initials: C
authors.lastname: Aguayo
authors.forename: Carlos
authors.initials: C
authors.lastname: Calvo
authors.forename: Claudia
authors.initials: C
authors.lastname: Radojkovic
authors.forename: Benilde
authors.initials: B
authors.lastname: Riffo
authors.forename: Andrea
authors.initials: A
authors.lastname: Gleisner
authors.forename: Sylvia
authors.initials: S
authors.lastname: Asenjo
authors.forename: Natalia
authors.initials: N
authors.lastname: Ulloa
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002677:Chile; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009752:Nutritional Status / Q000502:physiology*; D009765:Obesity / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D052242:Adiponectin