title: Vascular abnormalities of the distal deep digital flexor tendon in 8 draught horses identified on histological examination.
abstract: The purpose of this study was to provide a detailed description of the vascular changes in the distal part of deep digital flexor tendon (DDFT). Eight isolated forelimbs were collected from 8 horses with DDF tendinopathy diagnosed post-mortem by ultrasound and gross anatomopathological examination. The samples were fixed in 10% neutral buffered formalin, softened in 4% phenol and dehydrated with ethylic alcohol. Goldner's Trichrome staining method was used. The histopathological examination revealed vascular proliferation associated with structural disorders of blood vessels. Angiogenesis, fibroplasia and consecutive hypertrophy of the vascular wall with or without vascular occlusion were the most common findings. Other histopathological findings were: endothelial cell edema, progressive metaplasia from squamous to cubic cells, vascular wall hyalinization, endothelial cells apoptosis/necrosis and endothelial desquamation. These results demonstrated damage of the distal deep digital flexor tendon vasculature which may progressively alter the structural integrity of the tendon and contribute to degenerative lesions.
authors.affiliation: Department I - Preclinical Sciences, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Mănăştur Street, 400372 Cluj-Napoca, Romania. melaniacrisan@gmail.com
authors.forename: Melania Ioana
authors.initials: MI
authors.lastname: Crişan
authors.forename: Aurel
authors.initials: A
authors.lastname: Damian
authors.forename: Adrian
authors.initials: A
authors.lastname: Gal
authors.forename: Viorel
authors.initials: V
authors.lastname: Miclăuş
authors.forename: Cristina L
authors.initials: CL
authors.lastname: Cernea
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Denoix
mesh_terms: D000818:Animals; D005534:Foot Diseases / Q000473:pathology / Q000662:veterinary*; D005552:Forelimb / Q000473:pathology*; D006651:Histocytochemistry / Q000662:veterinary; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D052256:Tendinopathy / Q000473:pathology / Q000662:veterinary*