title: Comparison of two different spectral domain optical coherence tomography devices in the detection of localized retinal nerve fiber layer defects.
abstract: OBJECTIVE
  To compare the detection of localized retinal nerve fiber layer (RNFL) defects by two different spectral domain optical coherence tomography (SD-OCT) devices.
  
  
  METHODS
  Eyes of 42 normal control subjects and 48 patients with a localized RNFL defect on red-free fundus photographs were imaged by the Cirrus (Carl Zeiss Meditec, Dublin, CA, USA) and 3D OCT (Topcon, Tokyo, Japan) devices. We compared sensitivities, specificities, and area under the receiver operating characteristic curves (AUCs) of circumpapillary RNFL (cpRNFL) thickness and ganglion cell complex (GCC) parameters between the two devices.
  
  
  RESULTS
  The devices provided different cpRNFL thickness measurements. The highest sensitivities at fixed specificities of 80 % (Cirrus: 83.3 %; 3D OCT: 77.1 %) and 95 % (Cirrus: 69.8 %; 3D OCT: 68.8 %) and the largest AUCs (Cirrus: 0.90; 3D OCT: 0.88) obtained by the cpRNFL parameters of the two devices were similar. Based on the internal normative database, the deviation-from-normal map of the Cirrus OCT device and the 36-segment map of the 3D OCT device had the highest sensitivity (89.6 and 91.7 %, respectively). Among the macular GCC parameters of the 3D OCT device, inferior macular RNFL thickness had the highest sensitivity (81.2 % at a specificity of 80 %) and the largest AUC (0.89).
  
  
  CONCLUSIONS
  Although the two SD-OCT devices have different measurement protocols, they showed similar abilities for the detection of a localized RNFL defect.
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Korea.
authors.forename: Ko Eun
authors.initials: KE
authors.lastname: Kim
authors.forename: Seong Joon
authors.initials: SJ
authors.lastname: Ahn
authors.forename: Dong Myung
authors.initials: DM
authors.lastname: Kim
mesh_terms: D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012372:ROC Curve; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000295:instrumentation*
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