title: [Allergy of calcium phosphate cement material following skull reconstruction: a case report].
abstract: The paste form of calcium phosphate cement is often used in skull reconstruction because of the biocompatibility and early handling of these cements. Although it had rarely been shown to produce a foreign body reaction, we encountered a patient who experienced an allergic reaction to calcium phosphate cements(Biopex®. A patch test was performed and a positive reaction to magnesium phosphate was obtained. Biopex® contains magnesium phosphate, so we diagnosed this case as allergic reaction. Pathological analysis revealed infiltration of plasmacytes in the bone flap around the calcium phosphate cement. The postoperative course was uneventful 3 years after surgery. Allergy to calcium phosphate cements is rare, but must be considered in differential diagnosis of its side effects.
authors.affiliation: Department of Neurosurgery, Toyooka Hospital, Kobe-city, Hyogo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Mizowaki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miyake
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yoshimoto
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Matsuura
authors.forename: Sou
authors.initials: S
authors.lastname: Akiyama
mesh_terms: D001843:Bone Cements / Q000009:adverse effects*; D018786:Bone Substitutes / Q000009:adverse effects*; D002130:Calcium Phosphates / Q000009:adverse effects* / Q000276:immunology; D002809:Chondroitin Sulfates / Q000009:adverse effects; D006801:Humans; D006882:Hydroxyapatites / Q000009:adverse effects; D017616:Magnesium Compounds / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000276:immunology; D019651:Plastic Surgery Procedures / Q000379:methods; D012886:Skull / Q000601:surgery*; D013386:Succinates / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: C481019:Biopex; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D006882:Hydroxyapatites; D017616:Magnesium Compounds; D010710:Phosphates; D013386:Succinates; C030781:magnesium phosphate; D002809:Chondroitin Sulfates