title: Predictors of visual outcome in eyes with choroidal neovascularization secondary to age related macular degeneration treated with intravitreal bevacizumab monotherapy.
abstract: OBJECTIVE
  To evaluate the predictors of visual improvement in eyes with naive choroidal neovascularization secondary to age-related macular degeneration (CNV -AMD) treated with intravitreal bevacizumab (IVB) monotherapy.
  
  
  METHODS
  Fifty eyes with naive CNV- AMD with pretreatment best-corrected visual acuity (BCVA) better than 20/200 and treated with IVB monotherapy were evaluated. Several variables including age, sex, pre-treatment BCVA, CNV type and lesion size on fluorescein angiogram as well as SD-OCT parameters including pre-treatment central macular thickness (CMT), inner-segment/outer-segment (IS/OS) junction integrity, and external limiting membrane (ELM) integrity were analyzed to predict visual outcome.
  
  
  RESULTS
  On univariate regression, pretreatment ELM damage was associated with less visual improvement after treatment (P=0.0145). However, ELM damage predicted only 10% of the visual outcome. On multivariate regression, pretreatment BCVA, IS/OS junction, and ELM integrity on SD-OCT were the significant predictors for the treatment effect and together predicted 37% of visual improvement.
  
  
  CONCLUSIONS
  Pretreatment BCVA, ELM and IS/OS junction integrity on SD-OCT are of significant value in predicting the visual improvement in naive wet AMD patients treated with IVB monotherapy.
authors.affiliation: Jacob's Retina Center at Shiley Eye Center, University of California, San Diego, USA ; L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Jay
authors.initials: J
authors.lastname: Chhablani
authors.forename: Jae Suk
authors.initials: JS
authors.lastname: Kim
authors.forename: William R
authors.initials: WR
authors.lastname: Freeman
authors.forename: Igor
authors.initials: I
authors.lastname: Kozak
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wang
authors.forename: Lingyun
authors.initials: L
authors.lastname: Cheng
keywords: age-related macular degeneration; avastin; choroidal neovascularization; external limiting membrane
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