title: Multicomponent assembly of diverse pyrazin-2(1H)-one chemotypes.
abstract: An expedient and concise Ugi-based approach for the rapid assembly of pyrazin-2(1H)-one-based frameworks has been developed. This convergent approach encompasses skeletal, functional and stereochemical diversity, exhibiting an unusually high bond-forming efficiency as well as high structure and step economies. The method involves the use of readily available commercial reagents and is an example of the reconciliation of structural complexity with operational simplicity in a time- and cost-effective manner.
authors.affiliation: Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, Santiago de Compostela, 15782, Spain.
authors.forename: Jhonny
authors.initials: J
authors.lastname: Azuaje
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: El Maatougui
authors.forename: José M
authors.initials: JM
authors.lastname: Pérez-Rubio
authors.forename: Alberto
authors.initials: A
authors.lastname: Coelho
authors.forename: Franco
authors.initials: F
authors.lastname: Fernández
authors.forename: Eddy
authors.initials: E
authors.lastname: Sotelo
mesh_terms: D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D003500:Cyclization; D055808:Drug Discovery; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011719:Pyrazines