title: Anemia and transfusion in critically ill pediatric patients: a review of etiology, management, and outcomes.
abstract: This article describes the incidence and etiology of anemia in critically ill children. In addition, the article details the pathophysiology and clinical ramifications of anemia in this population. The use of transfused packed red blood cells as a therapy for anemia in critically ill patients is also discussed, including the indications for and complications associated with this practice as well as potential reasons for these complications. Finally, the article lists some therapeutic practices that may lessen the risks associated with transfusion, and briefly discusses the use of blood substitutes.
authors.affiliation: Division of Pediatric Critical Care Medicine, Department of Pediatrics, Stony Brook Long Island Children's Hospital, 100 Nicolls Road Stony Brook, NY 11794, USA. daniel.sloniewsky@sbumed.org
authors.forename: Daniel
authors.initials: D
authors.lastname: Sloniewsky
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology*; D000740:Anemia / Q000150:complications / Q000209:etiology / Q000628:therapy*; D001802:Blood Substitutes / Q000627:therapeutic use; D001803:Blood Transfusion / Q000379:methods / Q000592:standards*; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness / Q000628:therapy; D004921:Erythropoietin / Q000172:deficiency / Q000502:physiology / Q000627:therapeutic use*; D006438:Hemodilution / Q000009:adverse effects / Q000592:standards; D006801:Humans; D056747:Immunomodulation; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007501:Iron / Q000627:therapeutic use*; D018962:Phlebotomy / Q000009:adverse effects; D012307:Risk Factors; D065227:Transfusion Reaction; D016896:Treatment Outcome
chemical_list: D001802:Blood Substitutes; D004921:Erythropoietin; D007501:Iron