title: Takotsubo cardiomyopathy: definition and clinical profile.
abstract: Takotsubo cardiomyopathy (TTC) is an increasingly recognized, reversible cardiomyopathy with a clinical presentation that mimics an acute coronary syndrome but without evidence of obstructive coronary lesions. Typical presentation involves chest pain and/or dyspnea, transient ST-segment elevation on the electrocardiogram, and a modest increase in cardiac troponin. Cardiac imaging demonstrates wall-motion abnormalities that extend beyond the territory of a single epicardial coronary artery, and the absence of obstructive coronary lesions. Supportive treatment leads to spontaneous, rapid recovery of ventricular function, but about 10% of patients have recurrent events. This article reviews the defining features and clinical profile of TTC.
authors.affiliation: Department of Internal Medicine, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27710, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Summers
authors.forename: Abhiram
authors.initials: A
authors.lastname: Prasad
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D054549:Takotsubo Cardiomyopathy / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*