title: Toxicologic assessment of a commercial decolorized whole leaf aloe vera juice, lily of the desert filtered whole leaf juice with aloesorb.
abstract: Aloe vera, a common ingredient in cosmetics, is increasingly being consumed as a beverage supplement. Although consumer interest in aloe likely stems from its association with several health benefits, a concern has also been raised by a National Toxicology Program Report that a nondecolorized whole leaf aloe vera extract taken internally by rats was associated with intestinal mucosal hyperplasia and ultimately malignancy. We tested a decolorized whole leaf (DCWL) aloe vera, treated with activated charcoal to remove the latex portion of the plant, for genotoxicity in bacteria, acute/subacute toxicity in B6C3F1 mice, and subchronic toxicity in F344 rats. We found this DCWL aloe vera juice to be nongenotoxic in histidine reversion and DNA repair assays. Following acute administration, mice exhibited no adverse signs at 3- or 14-day evaluation periods. When fed to male and female F344 rats over 13 weeks, DCWL aloe led to no toxicity as assessed by behavior, stools, weight gain, feed consumption, organ weights, and hematologic or clinical chemistry profiles. These rats had intestinal mucosal morphologies-examined grossly and microscopically-that were similar to controls. Our studies show that oral administration of this DCWL aloe juice has a different toxicology profile than that of the untreated aloe juice at exposures up to 13 weeks.
authors.affiliation: LSU School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA ; Comparative Biomedical Sciences Department, LSU School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA.
authors.forename: Inder
authors.initials: I
authors.lastname: Sehgal
authors.forename: Wallace D
authors.initials: WD
authors.lastname: Winters
authors.forename: Michael
authors.initials: M
authors.lastname: Scott
authors.forename: Andrew
authors.initials: A
authors.lastname: David
authors.forename: Glenn
authors.initials: G
authors.lastname: Gillis
authors.forename: Thaya
authors.initials: T
authors.lastname: Stoufflet
authors.forename: Anand
authors.initials: A
authors.lastname: Nair
authors.forename: Konstantine
authors.initials: K
authors.lastname: Kousoulas
references.citation: Regul Toxicol Pharmacol. 2010 Jun;57(1):90-8
references.pmid: 20096744
references.citation: Natl Toxicol Program Tech Rep Ser. 2001 Jun;493:1-278
references.pmid: 12563347
references.citation: Appl Environ Microbiol. 1977 Nov;34(5):529-33
references.pmid: 563214
references.citation: J Ayurveda Integr Med. 2010 Oct;1(4):273-9
references.pmid: 21731374
references.citation: Biopharm Drug Dispos. 1995 Jul;16(5):351-80
references.pmid: 8527686
references.citation: Evid Based Complement Alternat Med. 2011;2011:365359
references.pmid: 21528006
references.citation: Molecules. 2008 Aug 08;13(8):1599-616
references.pmid: 18794775
references.citation: Natl Toxicol Program Tech Rep Ser. 2013 Aug;(577):1-266
references.pmid: 24042237
references.citation: Phytother Res. 2002 Dec;16(8):712-8
references.pmid: 12458471
references.citation: Mutat Res. 1996 Dec 20;371(3-4):165-73
references.pmid: 9008718
references.citation: N Engl J Med. 1987 Oct 22;317(17):1098
references.pmid: 3657876
references.citation: Appl Environ Microbiol. 1996 Apr;62(4):1242-7
references.pmid: 8919784
references.citation: J Nutr Sci Vitaminol (Tokyo). 2003 Aug;49(4):292-6
references.pmid: 14598919
references.citation: Planta Med. 2012 Mar;78(4):311-6
references.pmid: 22198821
references.citation: J Food Sci. 2012 Jan;77(1):T2-9
references.pmid: 22260137
references.citation: Biol Pharm Bull. 2006 Jul;29(7):1418-22
references.pmid: 16819181
references.citation: Clin Exp Pharmacol Physiol. 2006 Mar;33(3):232-7
references.pmid: 16487267
references.citation: Toxicology. 1989 Aug;57(3):227-40
references.pmid: 2667196
references.citation: Asian Pac J Trop Biomed. 2012 Oct;2(10):835-8
references.pmid: 23569857
references.citation: J Agric Food Chem. 2001 Feb;49(2):1030-4
references.pmid: 11262067
references.citation: Chem Pharm Bull (Tokyo). 1988 Nov;36(11):4462-6
references.pmid: 3246014
references.citation: Environ Mol Mutagen. 1997;29(1):1-9
references.pmid: 9020301
references.citation: Br J Community Nurs. 2010 Jun;15(6):280-2
references.pmid: 20679979
references.citation: Mutat Res. 1990 Jan;240(1):1-12
references.pmid: 2294411
references.citation: Life Sci. 2002 Sep 6;71(16):1879-92
references.pmid: 12175703