title: Connecting the study of wild influenza with the potential for pandemic disease.
abstract: Continuing outbreaks of pathogenic (H5N1) and pandemic (SOIVH1N1) influenza have underscored the need to understand the origin, characteristics, and evolution of novel influenza A virus (IAV) variants that pose a threat to human health. In the last 4-5years, focus has been placed on the organization of large-scale surveillance programs to examine the phylogenetics of avian influenza virus (AIV) and host-virus relationships in domestic and wild animals. Here we review the current gaps in wild animal and environmental surveillance and the current understanding of genetic signatures in potentially pandemic strains.
authors.affiliation: Massachusetts Institute of Technology, Cambridge, MA, United States. jrun@mit.edu
authors.forename: Jonathan
authors.initials: J
authors.lastname: Runstadler
authors.forename: Nichola
authors.initials: N
authors.lastname: Hill
authors.forename: Islam T M
authors.initials: IT
authors.lastname: Hussein
authors.forename: Wendy
authors.initials: W
authors.lastname: Puryear
authors.forename: Mandy
authors.initials: M
authors.lastname: Keogh
mesh_terms: D000818:Animals; D001717:Birds; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D016679:Genome, Viral; D054884:Host-Pathogen Interactions; D006801:Humans; D009980:Influenza A virus / Q000502:physiology; D005585:Influenza in Birds / Q000453:epidemiology* / Q000635:transmission; D007251:Influenza, Human / Q000453:epidemiology* / Q000635:transmission; D058873:Pandemics; D062486:Public Health Surveillance
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