title: Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers.
abstract: A new strategy towards [(18)F]trifluoromethyl-containing compounds is developed. [(18)F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [(18)F]trifluoromethyl carbinols in good yields.
authors.affiliation: Department of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, The Netherlands.
authors.forename: Dion
authors.initials: D
authors.lastname: van der Born
authors.forename: J Koos D M
authors.initials: JK
authors.lastname: Herscheid
authors.forename: Romano V A
authors.initials: RV
authors.lastname: Orru
authors.forename: Danielle J
authors.initials: DJ
authors.lastname: Vugts
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D005617:Chlorofluorocarbons, Methane / Q000138:chemical synthesis* / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D049268:Positron-Emission Tomography
chemical_list: D000447:Aldehydes; D005617:Chlorofluorocarbons, Methane; D005462:Fluorine Radioisotopes; D007659:Ketones; C009554:fluoroform