title: Association of peroxisome proliferator-activated receptor α/δ/γ with obesity, and gene-gene interaction, in the Chinese Han population.
abstract: BACKGROUND
  We investigated the association of 10 single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptors (PPARs) with obesity and the additional role of gene-gene interaction.
  
  
  METHODS
  Participants were recruited within the framework of the Prevention of Multiple Metabolic Disorders and MS in Jiangsu Province cohort population survey of an urban community in China. In total, 820 subjects (513 nonobese adults, 307 obese adults) were randomly selected, and no individuals were consanguineous. Ten SNPs (rs135539, rs4253778, rs1800206, rs2016520, rs9794, rs10865710, rs1805192, rs709158, rs3856806, and rs4684847) were genotyped and analyzed.
  
  
  RESULTS
  After covariate adjustment, minor alleles of rs2016520 in PPARδ and rs10865170 in PPARγ were associated with lower BMI (P < 0.01 for all). Generalized multifactor dimensionality reduction analysis showed significant gene-gene interaction among rs2016520, rs9794, and rs10865170 in 3-dimensional models (P = 0.0010); prediction accuracy was 0.6011 and cross-validation consistency was 9/10. It also showed significant gene-gene interaction between rs2016520 and rs10865170 in all 2-dimensional models (P = 0.0010); prediction accuracy was 0.6072 and cross-validation consistency was 9/10.
  
  
  CONCLUSIONS
  rs2016520 and rs10865170 were associated with lower obesity risk. In addition, interaction was identified among rs2016520, rs9794, and rs10865170 in obesity.
authors.affiliation: Changzhou Center for Disease Control and Prevention, Changzhou, Jiangsu, China.
authors.forename: Wenshu
authors.initials: W
authors.lastname: Luo
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Guo
authors.forename: Ming
authors.initials: M
authors.lastname: Wu
authors.forename: Chao
authors.initials: C
authors.lastname: Hao
authors.forename: Xiaoshu
authors.initials: X
authors.lastname: Hu
authors.forename: Zhengyuan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Zhiwu
authors.initials: Z
authors.lastname: Zhou
authors.forename: Xingjuan
authors.initials: X
authors.lastname: Yao
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhang
authors.forename: Jingchao
authors.initials: J
authors.lastname: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D001483:Base Sequence; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D004843:Epistasis, Genetic; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D047493:PPAR alpha / Q000235:genetics*; D047494:PPAR delta / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D047493:PPAR alpha; D047494:PPAR delta; D047495:PPAR gamma
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