title: Molecular views of Arf-like small GTPases in cilia and ciliopathies.
abstract: The primary cilia are microtubule-based organelles that protrude from most of the eukaryotic cells. Recognized as the cell's antenna, primary cilium functions as a signaling hub for many physiologically and developmentally important signaling cascades. Ciliary dysfunction causes a wide spectrum of syndromic human genetic diseases collectively termed "ciliopathies". Mounting evidences have shown that various small GTPases have been implicated in the context of cilia as well as human ciliopathies. However, how these small GTPases affect cilia formation and function remains poorly understood. Here we review and discuss the ciliary role of three Arf-like small GTPases (Arls), Arl3, Arl6, and Arl13b.
authors.affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jinghua
authors.initials: J
authors.lastname: Hu
authors.forename: Kun
authors.initials: K
authors.lastname: Ling
mesh_terms: D020727:ADP-Ribosylation Factors / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002923:Cilia / Q000235:genetics / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D020409:Molecular Motor Proteins / Q000235:genetics / Q000378:metabolism; D009024:Morphogenesis; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D020409:Molecular Motor Proteins; C491435:ARL6 protein, human; D020727:ADP-Ribosylation Factors; C490247:ARL3 protein, human; C530391:ARL13B protein, human
keywords: Arl; Cilia; Ciliopathy; Small GTPase
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