title: Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY.
abstract: We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with the same intake dose, but did not significantly affect the L-Ser level when compared with L-Ser administration.
authors.affiliation: Division of Systems Biology, Department of Innovative Science and Technology for Bio-industry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Esaki
authors.forename: Taketo
authors.initials: T
authors.lastname: Ohmori
authors.forename: Motohiro
authors.initials: M
authors.lastname: Maebuchi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nakamori
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Ohshima
authors.forename: Shigeki
authors.initials: S
authors.lastname: Furuya
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004044:Dietary Proteins / Q000032:analysis; D004151:Dipeptides / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D014443:Tyrosine / Q000097:blood* / Q000378:metabolism*
chemical_list: D004044:Dietary Proteins; D004151:Dipeptides; C584529:L-Ser-L-Try; D014443:Tyrosine