title: Brief report: atypical neuromagnetic responses to illusory auditory pitch in children with autism spectrum disorders.
abstract: Atypical auditory perception is a widely recognised but poorly understood feature of autism. In the current study, we used magnetoencephalography to measure the brain responses of 10 autistic children as they listened passively to dichotic pitch stimuli, in which an illusory tone is generated by sub-millisecond inter-aural timing differences in white noise. Relative to control stimuli that contain no inter-aural timing differences, dichotic pitch stimuli typically elicit an object related negativity (ORN) response, associated with the perceptual segregation of the tone and the carrier noise into distinct auditory objects. Autistic children failed to demonstrate an ORN, suggesting a failure of segregation; however, comparison with the ORNs of age-matched typically developing controls narrowly failed to attain significance. More striking, the autistic children demonstrated a significant differential response to the pitch stimulus, peaking at around 50 ms. This was not present in the control group, nor has it been found in other groups tested using similar stimuli. This response may be a neural signature of atypical processing of pitch in at least some autistic individuals.
authors.affiliation: Department of Cognitive Science, Macquarie University, Sydney, NSW, 2109, Australia, jon.brock@mq.edu.au.
authors.forename: Jon
authors.initials: J
authors.lastname: Brock
authors.forename: Samantha
authors.initials: S
authors.lastname: Bzishvili
authors.forename: Melanie
authors.initials: M
authors.lastname: Reid
authors.forename: Michael
authors.initials: M
authors.lastname: Hautus
authors.forename: Blake W
authors.initials: BW
authors.lastname: Johnson
mesh_terms: D000161:Acoustic Stimulation; D001303:Auditory Cortex / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009622:Noise; D010898:Pitch Perception / Q000502:physiology*
references.citation: Neurosci Lett. 2003 Mar 6;338(3):197-200
references.pmid: 12581830
references.citation: Neuropsychologia. 2010 Jul;48(9):2465-75
references.pmid: 20433857
references.citation: J Acoust Soc Am. 2005 Jan;117(1):275-80
references.pmid: 15704420
references.citation: Neuroreport. 2004 Aug 26;15(12):1867-70
references.pmid: 15305126
references.citation: Clin Neurophysiol. 2000 Feb;111(2):220-36
references.pmid: 10680557
references.citation: J Autism Dev Disord. 1999 Jun;29(3):213-24
references.pmid: 10425584
references.citation: Neuroreport. 1998 Sep 14;9(13):3001-5
references.pmid: 9804305
references.citation: Philos Trans R Soc Lond B Biol Sci. 2008 Mar 12;363(1493):1087-104
references.pmid: 17890188
references.citation: Neuropsychologia. 2013 Mar;51(4):633-41
references.pmid: 23333528
references.citation: Hear Res. 2007 Jul;229(1-2):225-36
references.pmid: 17303355
references.citation: Autism Res. 2010 Feb;3(1):8-18
references.pmid: 20063319
references.citation: Neuropsychologia. 2010 Jul;48(9):2610-9
references.pmid: 20466010
references.citation: Clin Neurophysiol. 2003 Sep;114(9):1671-80
references.pmid: 12948796
references.citation: Brain Res. 2005 Dec 20;1066(1-2):147-57
references.pmid: 16325159
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5567-72
references.pmid: 12702776
references.citation: J Child Psychol Psychiatry. 2004 Sep;45(6):1107-14
references.pmid: 15257667
references.citation: Biol Psychol. 2009 Dec;82(3):301-7
references.pmid: 19751798
references.citation: J Autism Dev Disord. 1991 Sep;21(3):303-13
references.pmid: 1938776
references.citation: Electroencephalogr Clin Neurophysiol. 1986 Sep;65(5):344-60
references.pmid: 2427326
references.citation: Hear Res. 2004 Dec;198(1-2):87-92
references.pmid: 15617227
references.citation: J Autism Dev Disord. 2009 Jul;39(7):1087-91
references.pmid: 19283461