title: Understanding the physiology of schizophrenia.
abstract: The physiology of schizophrenia includes complex genetic and environmental interactions. Current treatment largely focuses on positive symptoms, but many patients with schizophrenia present with additional symptoms and conditions that hinder their social and occupational functioning. The study of the physiology of this disorder has expanded beyond dopamine dysfunction to include the glutamate, serotonin, and nicotinic/acetylcholine systems, as well as physiologic abnormalities such as diabetes and inflammation. Clinicians who understand these additional problem areas can incorporate them into their assessment and treatment plans for patients with schizophrenia.
authors.affiliation: Department of Psychiatry and Behavioral Science, Texas A&M College of Medicine, College Station, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Kirkpatrick
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001526:Behavioral Symptoms / Q000175:diagnosis*; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D010346:Patient Care Management; D011603:Psychophysiology; D012559:Schizophrenia / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D012565:Schizophrenic Psychology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents