title: United states acculturation and cancer patients' end-of-life care.
abstract: BACKGROUND
  Culture shapes how people understand illness and death, but few studies examine whether acculturation influences patients' end-of-life treatment preferences and medical care.
  
  
  RESULTS
  In this multi-site, prospective, longitudinal cohort study of terminally-ill cancer patients and their caregivers (n = 171 dyads), trained interviewers administered the United States Acculturation Scale (USAS). The USAS is a 19-item scale developed to assess the degree of "Americanization" in first generation or non-US born caregivers of terminally-ill cancer patients. We evaluated the internal consistency, concurrent, criterion, and content validity of the USAS. We also examined whether caregivers' USAS scores predicted patients' communication, treatment preferences, and end-of-life medical care in multivariable models that corrected for significant confounding influences (e.g. education, country of origin, English proficiency). The USAS measure was internally consistent (Cronbach α = 0.98); and significantly associated with US birthplace (r = 0.66, P<0.0001). USAS scores were predictive of patients' preferences for prognostic information (AOR = 1.31, 95% CI:1.00-1.72), but not comfort asking physicians' questions about care (AOR 1.23, 95% CI:0.87-1.73). They predicted patients' preferences for feeding tubes (AOR = 0.68, 95% CI:0.49-0.99) and wish to avoid dying in an intensive care unit (AOR = 1.36, 95% CI:1.05-1.76). Scores indicating greater acculturation were also associated with increased odds of patient participation in clinical trials (AOR = 2.20, 95% CI:1.28-3.78), compared with lower USAS scores, and greater odds of patients receiving chemotherapy (AOR = 1.59, 95% CI:1.20-2.12).
  
  
  CONCLUSIONS
  The USAS is a reliable and valid measure of "Americanization" associated with advanced cancer patients' end-of-life preferences and care. USAS scores indicating greater caregiver acculturation were associated with increased odds of patient participation in cancer treatment (chemotherapy, clinical trials) compared with lower scores. Future studies should examine the effects of acculturation on end-of-life care to identify patient and provider factors that explain these effects and targets for future interventions to improve care (e.g., by designing more culturally-competent health education materials).
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
authors.forename: Alexi A
authors.initials: AA
authors.lastname: Wright
authors.forename: Heather
authors.initials: H
authors.lastname: Stieglitz
authors.forename: Yankel M
authors.initials: YM
authors.lastname: Kupersztoch
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Paulk
authors.forename: Yookyung
authors.initials: Y
authors.lastname: Kim
authors.forename: Ingrid T
authors.initials: IT
authors.lastname: Katz
authors.forename: Francisco
authors.initials: F
authors.lastname: Munoz
authors.forename: Rachel B
authors.initials: RB
authors.lastname: Jimenez
authors.forename: Jan
authors.initials: J
authors.lastname: Mutchler
authors.forename: Lorna
authors.initials: L
authors.lastname: Rivera
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Back
authors.forename: Holly G
authors.initials: HG
authors.lastname: Prigerson
mesh_terms: D000069:Acculturation; D000328:Adult; D000368:Aged; D017028:Caregivers; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D057240:Patient Preference; D010817:Physician-Patient Relations; D011446:Prospective Studies; D015203:Reproducibility of Results; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013727:Terminal Care; D014481:United States
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