title: Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy in tertiary care hospitals of Jammu.
abstract: BACKGROUND
  To study whether the administration of recombinant human erythropoietin increases the amount of autologous blood that can be collected before orthopaedic surgery.
  
  
  METHODS
  We conducted a randomized controlled trial of recombinant human erythropoietin in 68 adults scheduled for elective orthopedic procedures. The patients received either erythropoietin 600 units/kg of body weight or placebo intravenously every 5(th) day prior to each phlebotomy for 21 days during which time up to 5 units of blood was collected. Patients were excluded from donation when their hematocrit values were less than 33%. All patients received iron sulphate 325mg orally 3 times daily. The mean number of units collected per patient was 4.33 ± 0.4 for erythropoietin group and 3.05± 0.71 for the placebo group.
  
  
  RESULTS
  The mean packed red cell volume donated by patients who received erythropoietin was 32% greater than that donated by patients who received placebo (196.3 vs. 169.4 ml, p<0.05). 68% in the placebo group and 9% of patients treated with erythropoietin were unable to donate ≥4 units. No adverse effects were attributed to erythropoietin. While participating in the study, complications developed in 2 patients one in each group necessitating their removal from the study.
  
  
  CONCLUSIONS
  We conclude that recombinant human erythropoietin increases the ability of the patients about to undergo elective surgery to donate autologous blood units.
authors.affiliation: Department of Transfusion Medicine, Acharya Shri Chander College of Medical Sciences and Hospital, Sidhra, Jammu, India.
authors.forename: Kumkum
authors.initials: K
authors.lastname: Sharma
authors.forename: Sumit B
authors.initials: SB
authors.lastname: Sharma
authors.forename: Imran A
authors.initials: IA
authors.lastname: Pukhta
authors.forename: Amit B
authors.initials: AB
authors.lastname: Sharma
authors.forename: Abdul Q
authors.initials: AQ
authors.lastname: Salaria
keywords: Autologous blood; preoperative; recombinant human erythropoietin
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