title: A novel therapeutic strategy for adolescent idiopathic scoliosis based on osteoporotic concept.
abstract: Adolescent idiopathic scoliosis (AIS) is a complex three dimensional spinal deformity which occurs mostly in prepubertal and pubertal girls. Although bracing and surgery have been the mainstays of treatment for AIS, because of the complications and poor compliance, many patients with this disorder continue to experience significant residual symptoms. The etiology and pathogenesis of AIS is unclear, but recent studies show the association between osteopenia and AIS and imply that osteopenia play a causative role in the development of AIS. Anti-osteoporosis treatment can improve bone strength, prevent osteoporosis and rebalance the OPG-RANK-RANKL system, which may help to prevent curve progression in AIS. This report proposes that anti-osteoporosis treatment may be an effective treatment for AIS.
authors.affiliation: Department of Spine Surgery, The 2nd Xiangya Hospital of Central South University, Changsha 410011, China.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Lu
authors.forename: Zhehao
authors.initials: Z
authors.lastname: Dai
authors.forename: Guohua
authors.initials: G
authors.lastname: Lv
authors.forename: Yijun
authors.initials: Y
authors.lastname: Kang
authors.forename: Yebin
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D061067:Antibodies, Monoclonal, Humanized; D001851:Bone Diseases, Metabolic / Q000150:complications* / Q000188:drug therapy*; D000069448:Denosumab; D005260:Female; D006801:Humans; D008954:Models, Biological; D053244:Osteoprotegerin / Q000378:metabolism; D010880:Piperidines; D053245:RANK Ligand / Q000378:metabolism; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000378:metabolism; D012600:Scoliosis / Q000209:etiology / Q000517:prevention & control*
chemical_list: C479416:4-(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-hydroxybutyl)-1,2,3,6-tetrahydropyridine; D061067:Antibodies, Monoclonal, Humanized; D053244:Osteoprotegerin; D010880:Piperidines; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; D000069448:Denosumab