title: Possible role of NUCB2/nesfatin-1 in adipogenesis.
abstract: NUCB2 and its proteolytically cleaved product nesfatin-1 were initially identified as hypothalamic neuroproteins that inhibit food intake, via a leptin-independent pathway. Since then recent studies have found NUCB2/nesfatin-1 to be expressed both centrally, as well as in peripheral tissues. The recent implementation of novel experimental approaches has produced a large body of evidence implicating NUCB2/nesfatin-1 in a diverse range of biological functions and in the modulation of food intake, energy homeostasis and metabolism. In this review, we discuss the discovery of NUCB2 and its proteolytic product nesfatin-1, and its expression in both central and peripheral tissues. In addition we shed light on the most recent discoveries supporting the role for NUCB2/nesfatin-1 in peripheral tissues and its association with metabolic alterations. Moreover, we highlight the importance of NUCB2 and nesfatin-1 in adipose tissue, its regulation of adipogenesis and obesity-associated metabolic diseases.
authors.affiliation: Division of Metabolic & Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK. Harpal.Randeva@warwick.ac.uk.
authors.forename: Manjunath
authors.initials: M
authors.lastname: Ramanjaneya
authors.forename: Melisande
authors.initials: M
authors.lastname: Addison
authors.forename: Harpal S
authors.initials: HS
authors.lastname: Randeva
mesh_terms: D050156:Adipogenesis / Q000502:physiology*; D000818:Animals; D002135:Calcium-Binding Proteins / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000502:physiology*; D000080866:Nucleobindins; D009765:Obesity / Q000503:physiopathology
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins