title: Squish and CuAAC: additive-free covalent monolayers of discrete molecules in seconds.
abstract: A terminal alkyne is immobilized rapidly into a full monolayer by squishing a small volume of a solution of the alkyne between an azide-modified surface and a copper plate. The monolayer is covalently attached to the surface through a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction, and the coverages of the immobilized electroactive alkyne species are quantified by cyclic voltammetry. A reaction time of less than 20 s is possible with no other reagents required. The procedure is effective under aerobic conditions using either an aqueous or aprotic organic solution of the alkyne (1-100 mM).
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305-5080, United States.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Pellow
authors.forename: T Daniel P
authors.initials: TD
authors.lastname: Stack
authors.forename: Christopher E D
authors.initials: CE
authors.lastname: Chidsey
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D010084:Oxidation-Reduction; D013997:Time Factors
chemical_list: D000480:Alkynes; D001386:Azides; D003300:Copper
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