title: Impact of preprocedural high-sensitivity C-reactive protein on contrast-induced nephropathy in patients undergoing primary percutaneous coronary intervention.
abstract: We assessed the impact of preprocedural high-sensitivity C-reactive protein (hsCRP) on the incidence of contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (p-PCI). We retrospectively studied 1452 patients with STEMI undergoing p-PCI. Baseline clinical characteristics, CIN incidence, and other inhospital clinical outcomes were compared among hsCRP quartiles; 212 (14.6%) patients developed CIN. The overall inhospital mortality rate was 4.5% (65 patients). Univariate analysis revealed CIN incidence was significantly associated with hsCRP, with 7.44% for quartile Q1 (<3.00 mg/L), 12.6% for Q2 (3.00-5.90 mg/L), 16.9% for Q3 (5.91-11.4 mg/L), and 21.49% for Q4 (>11.4 mg/L; P < .001). Patients with a higher hsCRP experienced a higher rate of inhospital complications. After adjusting for potential confounders, hsCRP >6.50 mg/L was significantly associated with the occurrence of CIN. Preprocedural hsCRP levels are significantly related to the incidence of CIN in patients with STEMI undergoing p-PCI.
authors.affiliation: 1Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, The Key Laboratory of Remodeling-Related Cardiovascular Disease, Ministry of Education, Beijing, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jian-Wei
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yu-Jie
authors.forename: Cao
authors.initials: C
authors.lastname: Shu-Jun
authors.forename: Yang
authors.initials: Y
authors.lastname: Qing
authors.forename: Yang
authors.initials: Y
authors.lastname: Shi-Wei
authors.forename: Nie
authors.initials: N
authors.lastname: Bin
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002681:China / Q000453:epidemiology; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D062645:Percutaneous Coronary Intervention; D011859:Radiography; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D002097:C-Reactive Protein
keywords: ST-segment elevation myocardial infarction; contrast-induced nephropathy; high-sensitivity C-reactive protein; primary percutaneous coronary intervention