title: Oxidized arachidonic acid and hexanal enhance mouse taste perception of monosodium glutamate.
abstract: OBJECTIVE
  Little is known about whether mammals use gustatory sense to detect compounds produced from oxidized oil as a taste or only use olfactory sense to detect the compounds as aroma. The present study examined the effects of oxidized arachidonic acid (AA) ethyl ester and hexanal, one predominant compound in oxidized AA, on mouse taste perception of monosodium glutamate (MSG).
  
  
  METHODS
  We examined the effects of oxidized ethyl AA and hexanal on chorda tympani (CT) nerve response to MSG using mouse electrophysiological technique. In addition, we evaluated the effects of aliphatic aldehydes and alcohol which are compounds structurally related to hexanal with carbon chain lengths or a functional group different from hexanal on taste perception of MSG using behavioral and electrophysiological studies.
  
  
  RESULTS
  The CT nerve responses to 10, 20, and 50 mM MSG with water extracts of oxidized ethyl AA was higher than that to MSG alone. A total of 1000 µM hexanal and pentanal enhanced mouse taste response to MSG, but 1000 µM propanal and 1-hexanol failed to increase the responses.
  
  
  CONCLUSIONS
  The products of oxidized ethyl AA and hexanal would enhance the taste sensation of MSG, which suggests that CT nerve input should be important for projection to the behavioral responses. The carbon chain length and the functional group of hexanal would be key factors of the hexanal effect on mouse taste perception of MSG.
authors.affiliation: Department of Food Science & Technology, Tokyo University of Marine Science & Technology, Tokyo, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Hidenori
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Ikukazu
authors.initials: I
authors.lastname: Tashima
authors.forename: Hideki
authors.initials: H
authors.lastname: Ushio
mesh_terms: D000447:Aldehydes / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology*; D002814:Chorda Tympani Nerve / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012903:Smell / Q000187:drug effects / Q000502:physiology; D012970:Sodium Glutamate / Q000378:metabolism*; D055697:Taste Perception / Q000187:drug effects* / Q000502:physiology*
chemical_list: D000447:Aldehydes; D016718:Arachidonic Acid; C010463:n-hexanal; C046012:pentanal; D012970:Sodium Glutamate