title: Paraneoplastic cutaneous manifestations: concepts and updates.
abstract: The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. In this review article, we discuss the paraneoplastic cutaneous manifestations strongly associated with neoplasms, which include acanthosis nigricans maligna, tripe palms, erythema gyratum repens, Bazex syndrome, acquired hypertrichosis lanuginosa, necrolytic migratory erythema, Leser-Trélat sign and paraneoplastic pemphigus. We also review the clinical manifestations of each condition and include updated knowledge on disease pathogenesis.
authors.affiliation: Catholic University of Brasília- UCB, Brasília, (DF), Brazil.
authors.forename: Josenilson Antônio da
authors.initials: JA
authors.lastname: Silva
authors.forename: Kleyton de Carvalho
authors.initials: Kde C
authors.lastname: Mesquita
authors.forename: Ana Carolina de Souza Machado
authors.initials: AC
authors.lastname: Igreja
authors.forename: Isabella Cristina Rodrigues Naves
authors.initials: IC
authors.lastname: Lucas
authors.forename: Aline Ferreira
authors.initials: AF
authors.lastname: Freitas
authors.forename: Sandra Maximiano de
authors.initials: SM
authors.lastname: Oliveira
authors.forename: Izelda Maria Carvalho
authors.initials: IM
authors.lastname: Costa
authors.forename: Iphis Tenfuss
authors.initials: IT
authors.lastname: Campbell
mesh_terms: D004502:Education, Medical, Continuing; D006801:Humans; D009336:Necrosis; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000473:pathology*; D011379:Prognosis; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology*; D011795:Surveys and Questionnaires
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