title: Neopterin: a potential marker in chronic peripheral arterial disease.
abstract: Neopterin is a marker of macrophage activation that has exhibited high plasma levels in atherosclerotic diseases including coronary heart disease and critical limb ischemia. The role of neopterin in chronic peripheral arterial disease (PAD) has yet to be elucidated. In the present study, neopterin (Ν) serum concentrations were analyzed in asymptomatic (AsP) and symptomatic (SyP) patients with PAD as well as controls (C). In total 120 subjects, 40 AsP [ankle brachial index (ABI) ≤0.90], 40 SyP (ABI ≤0.90 plus pain in legs) and 40 controls (ABI >0.9) were enrolled. The results of the present study showed that neopterin plasma levels were statistically different among the groups. These findings demonstrated that activation of N‑mediated monocyte‑macrophage, was also observed in chronic PAD.
authors.affiliation: Department of Medical and Pediatric Science, Section of Internal and Vascular Medicine, University of Catania, Catania I‑95125, Italy. ssignore@unict.it
authors.forename: Salvatore Santo
authors.initials: SS
authors.lastname: Signorelli
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Anzaldi
authors.forename: Valerio
authors.initials: V
authors.lastname: Fiore
authors.forename: Saverio
authors.initials: S
authors.lastname: Candido
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Marco
authors.forename: Katia
authors.initials: K
authors.lastname: Mangano
authors.forename: Cinzia
authors.initials: C
authors.lastname: Quattrocchi
authors.forename: Sergio
authors.initials: S
authors.lastname: Neri
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood*; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers; D019798:Neopterin