title: Clinical study to assess the efficacy and safety of a citrus polyphenolic extract of red orange, grapefruit, and orange (Sinetrol-XPur) on weight management and metabolic parameters in healthy overweight individuals.
abstract: The present study investigated the efficacy and safety effects of Sinetrol-XPur (polyphenolic citrus dry extract) in weight management; metabolic parameters; and inflammatory, glycemic and oxidative status. In a 12-week, randomized, double-blind, placebo-controlled trial, Sinetrol-XPur was given to overweight subjects twice daily with meals in the tested group (N = 47) versus a placebo group (N = 48). Waist and hip circumference and abdominal fat were decreased in the Sinetrol-XPur group as compared with the placebo group (p < 0.0001) (-5.71% vs. -1.56% for waist, -4.71% vs. -1.35% for hip and -9.73% vs. -3.18% for fat). Inflammatory markers were reduced (C-reactive protein: -22.87% vs. +61%; fibrinogen: -19.93% vs. -1.61%, p < 0.01). Oxidative stress was lowered as seen by the reduction of malondialdehyde (-14.03% vs. 2.76%) and the increase in superoxide dismutase and glutathione (17.38% vs. 2.19% and 4.63% vs. -2.36%, respectively, p < 0.01). No adverse effects were observed. Kidney, liver, and lipid panels remained unchanged. These results indicated that Sinetrol-XPur supplementation is a viable option for reducing abdominal fat, waist and hip circumference, and body weight and for improving inflammatory, glycemic, and oxidative status in healthy overweight individuals.
authors.affiliation: Fytexia, 3 rue d'Athènes-VIA EUROPA, 34350, Vendres, France.
authors.forename: Constantin
authors.initials: C
authors.lastname: Dallas
authors.forename: Alain
authors.initials: A
authors.lastname: Gerbi
authors.forename: Yves
authors.initials: Y
authors.lastname: Elbez
authors.forename: Philippe
authors.initials: P
authors.lastname: Caillard
authors.forename: Nicolas
authors.initials: N
authors.lastname: Zamaria
authors.forename: Maurice
authors.initials: M
authors.lastname: Cloarec
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects; D000328:Adult; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002097:C-Reactive Protein / Q000378:metabolism; D002957:Citrus / Q000737:chemistry*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D050177:Overweight / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D008315:Malondialdehyde; D002097:C-Reactive Protein; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: citrus extract; inflammation; overweight; oxidative stress; polyphenols; weight management