title: Resourceful synthesis of pyrazolo[1,5-a]pyrimidines under ultrasound irradiation.
abstract: Pyrazolo[1,5-a]pyrimidines were synthesized via the ultrasonic sonochemical method using the cyclocondensation reaction of 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones [CF3C(O)CH=C(R)(OMe) - where R=Me, Bu, i-Bu, Ph, 4-Me-C6H4, 4-F-C6H4, 4-Cl-C6H4, 4-Br-C6H4, naphth-2-yl and biphen-4-yl] - with 3-amino-5-methyl-1H-pyrazole in the presence of EtOH for 5 min. This methodology has several advantages, for example, it is a simple procedure, it has an easy work-up, mild conditions, short reaction times (5 min) and produces satisfactory yields (61-98%).
authors.affiliation: Center for Heterocyclic Chemistry (NUQUIMHE), Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Lilian
authors.initials: L
authors.lastname: Buriol
authors.forename: Taiana S
authors.initials: TS
authors.lastname: München
authors.forename: Clarissa P
authors.initials: CP
authors.lastname: Frizzo
authors.forename: Mara R B
authors.initials: MR
authors.lastname: Marzari
authors.forename: Nilo
authors.initials: N
authors.lastname: Zanatta
authors.forename: Helio G
authors.initials: HG
authors.lastname: Bonacorso
authors.forename: Marcos A P
authors.initials: MA
authors.lastname: Martins
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013010:Sonication
chemical_list: D011720:Pyrazoles; D011743:Pyrimidines; C527752:pyrazolo(1,5-a)pyrimidine