title: To be immunogenic, or not to be: that's the iPSC question.
abstract: The unexpected finding that autologous induced pluripotent stem cell (iPSC)-derived teratomas are immunogenic in syngeneic hosts sparked pessimism over their therapeutic potential; however, two recent reports (Guha et al., 2013 and Araki et al., 2013; the latter in this issue of Cell stem cell) contradict previous findings, showing no immunogenicity of in vitro differentiated syngeneic iPS-derived cells and supporting their safety.
authors.affiliation: Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan. kaneko.shin@cira.kyoto-u.ac.jp
authors.forename: Shin
authors.initials: S
authors.lastname: Kaneko
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamanaka