title: Association of dyslipidemia with renal cell carcinoma: a 1∶2 matched case-control study.
abstract: Abnormal serum lipid profiles are associated with the risk of some cancers, but the direction and magnitude of the association with renal cell carcinoma is unclear. We explore the relationship between serum lipids and renal cell carcinoma via a matched case-control study. A 1∶2-matched case-control study design was applied, where one renal cell carcinoma patient was matched to two non-renal-cell-carcinoma residents with respect to age (±0 year) and gender. Cases (n = 248) were inpatients with a primary diagnosis of renal cell carcinoma, confirmed by pathology after operations. Controls were sampled from a community survey database matched on age and gender with cases, 2 controls for each case. Stratified Cox proportional hazard regression analysis was used to obtain hazard ratios and corresponding 95% confidence intervals of lipids level and dyslipidemia for the risk of renal cell carcinoma. Elevated serum cholesterol (p<0.001), LDL cholesterol (p<0.001), and HDL cholesterol (p = 0.003) are associated with decreased hazard of renal cell carcinoma, adjusting for obesity, smoke, hypertension and diabetes. However, risk caused by hTG showed no statistical significance (p = 0.263). This study indicates that abnormal lipid profile influences the risk of renal cell carcinoma.
authors.affiliation: Department of Clinical Epidemiology, Peking University People's Hospital, Beijing, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Zhang
authors.forename: Luping
authors.initials: L
authors.lastname: Yu
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Yichang
authors.initials: Y
authors.lastname: Hao
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Liu
authors.forename: Yunbei
authors.initials: Y
authors.lastname: Xiao
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000150:complications*; D016022:Case-Control Studies; D050171:Dyslipidemias / Q000150:complications*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D012307:Risk Factors; D055815:Young Adult
chemical_list: D008055:Lipids
references.citation: Br J Nutr. 2009 Apr;101(8):1228-38
references.pmid: 18786276
references.citation: Clin Chem. 1990 Jan;36(1):15-9
references.pmid: 2297909
references.citation: Nat Rev Urol. 2010 May;7(5):277-85
references.pmid: 20448661
references.citation: J Am Coll Cardiol. 2010 Jun 22;55(25):2846-54
references.pmid: 20579542
references.citation: Lancet. 2009 Mar 28;373(9669):1119-32
references.pmid: 19269025
references.citation: J Biol Chem. 2001 Sep 14;276(37):34480-5
references.pmid: 11432865
references.citation: Can J Public Health. 1997 Mar-Apr;88(2):99-104
references.pmid: 9170688
references.citation: Br J Cancer. 2009 Oct 6;101(7):1202-6
references.pmid: 19690552
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2814-21
references.pmid: 19887581
references.citation: Int J Cancer. 2004 Jan 1;108(1):115-21
references.pmid: 14618625
references.citation: JAMA. 1999 May 5;281(17):1628-31
references.pmid: 10235157
references.citation: Kidney Int. 2005 Feb;67(2):647-52
references.pmid: 15673312
references.citation: J Natl Cancer Inst. 2011 Mar 16;103(6):508-19
references.pmid: 21285406
references.citation: Cancer Causes Control. 2002 Jun;13(5):417-26
references.pmid: 12146846
references.citation: Am J Epidemiol. 2006 Oct 1;164(7):652-64
references.pmid: 16877536
references.citation: Cancer Res. 2007 Jun 1;67(11):5569-74
references.pmid: 17522388
references.citation: Eur Urol. 1998;33(6):538-41
references.pmid: 9743694
references.citation: J Am Coll Cardiol. 2008 Sep 30;52(14):1141-7
references.pmid: 18804740
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1797-801
references.pmid: 16030119
references.citation: Cancer Causes Control. 1999 Aug;10(4):303-11
references.pmid: 10482489
references.citation: Lancet. 1985 Nov 23;2(8465):1150-4
references.pmid: 2865616
references.citation: Am J Epidemiol. 2007 Oct 15;166(8):932-40
references.pmid: 17656615
references.citation: Arch Intern Med. 2006 Sep 25;166(17):1871-7
references.pmid: 17000944
references.citation: Eur Heart J. 1998 Feb;19 Suppl A:A31-5
references.pmid: 9519340
references.citation: Thromb Haemost. 2001 Apr;85(4):730-5
references.pmid: 11341512
references.citation: Am J Clin Nutr. 2000 Feb;71(2):569-74
references.pmid: 10648273
references.citation: Am J Med. 1981 Oct;71(4):595-602
references.pmid: 7282748
references.citation: Int J Clin Lab Res. 2000;30(3):141-5
references.pmid: 11196072
references.citation: Int J Cancer. 2008 Feb 15;122(4):909-14
references.pmid: 17957783
references.citation: J Urol. 2001 Nov;166(5):1611-23
references.pmid: 11586189
references.citation: Curr Opin Clin Nutr Metab Care. 2005 Mar;8(2):147-52
references.pmid: 15716792
references.citation: Int J Mol Med. 2000 Sep;6(3):307-11
references.pmid: 10934294
references.citation: Int J Cancer. 1999 Nov 12;83(4):435-40
references.pmid: 10508476
references.citation: J Am Coll Cardiol. 2007 Jul 31;50(5):409-18
references.pmid: 17662392
references.citation: Int J Cancer. 2008 May 15;122(10):2322-9
references.pmid: 18076041