title: Implantation with new three-dimensional porous titanium web for treatment of parietal bone defect in rabbit.
abstract: Titanium net (meshes) with excellent mechanical properties can promote bone compatibility and has been used as a repairing material for bone defects in clinical settings. In the present study, using spiral computed tomography (CT) and histomorphological techniques, we investigated the effect of a novel kind of titanium web with a three-dimensional (3D) porous structure on bone formation in rabbit skull (os parietal) defect. The images from the spiral CT scan demonstrate that the titanium web is completely fused with the surrounding bone tissue, even at the first month after implantation. The histomorphological findings show that different cells and tissues, including osseous tissue, connective tissue, and adipose cells, can easily grow into the 3D scaffold meshes of the titanium web, even in the center of the web and combine together as a whole body, suggesting that the titanium web possesses a very good biocompatibility, which is beneficial to the growth of bone tissue and promotes healing of the defected rabbit skull.
authors.affiliation: Key Laboratory for Medical Tissue Regeneration of Henan Province, Xinxiang Medical University, Xinxiang City, Henan, China. gzk_ljk@163.com
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Guo
authors.forename: Shouhei
authors.initials: S
authors.lastname: Iku
authors.forename: Lingmin
authors.initials: L
authors.lastname: Mu
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Takaki
authors.initials: T
authors.lastname: Shima
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Seki
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kuboki
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D004867:Equipment Design; D019637:Orthopedic Procedures / Q000295:instrumentation*; D016348:Osseointegration; D010294:Parietal Bone / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016062:Porosity; D011817:Rabbits; D013526:Surgical Mesh; D013997:Time Factors; D054457:Tissue Scaffolds; D014025:Titanium; D036542:Tomography, Spiral Computed
chemical_list: D014025:Titanium
keywords: Bone formation; Rabbit; Skull defect; Titanium web