title: Cycloaddition of chiral tert-butanesulfinimines with trimethylenemethane.
abstract: The cycloaddition of chiral tert-butanesulfinimines with trimethylenemethane is found to give facile access to methylene-pyrrolidines with good yields and diastereoselectivities. The full scope of the cycloaddition is explored, and a range of transformations of the formed methylenepyrrolidines to give a range of functionalized chiral pyrrolidines is presented.
authors.affiliation: School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, UK.
authors.forename: George
authors.initials: G
authors.lastname: Procopiou
authors.forename: William
authors.initials: W
authors.lastname: Lewis
authors.forename: Gareth
authors.initials: G
authors.lastname: Harbottle
authors.forename: Robert A
authors.initials: RA
authors.lastname: Stockman
mesh_terms: D002073:Butanes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D061565:Cycloaddition Reaction; D007097:Imines / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013452:Sulfonium Compounds / Q000737:chemistry*
chemical_list: D002073:Butanes; D007097:Imines; D011759:Pyrrolidines; D013452:Sulfonium Compounds; C522016:sulfinimine; C522820:trimethylenemethane; D008697:Methane