title: Adiponectin and traumatic brain injury.
abstract: Adiponectin, a circulating adipose-derived hormone regulating inflammation and energy metabolism, has beneficial actions on cardiovascular disorders. Recent studies have suggested that adiponectin might be a potential molecular target for ischemic stroke therapy; however, little is known about the effects of adiponectin on traumatic brain injury. The present study examined the immunoactivity of adiponectin.Adult male Sprague-Dawley rats were subjected to lateral fluid percussion injury using the Dragonfly device. Immuno-histochemical studies showed that the adiponectin expression was increased in the cerebral cortex at 24 h after injury and in the hippocampus at 72 h after injury. Our findings suggest that adiponectin might participate in the pathophysiological process occurring after traumatic brain injury.
authors.affiliation: Department of Neurosurgery, National Defense Medical College, Saitama, Japan. s.takeuchi@room.ocn.ne.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Kojiro
authors.initials: K
authors.lastname: Wada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nawashiro
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Uozumi
authors.forename: Naoki
authors.initials: N
authors.lastname: Otani
authors.forename: Hideo
authors.initials: H
authors.lastname: Osada
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Nagatani
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Takamoto
authors.initials: T
authors.lastname: Suzuki
authors.forename: Katsuji
authors.initials: K
authors.lastname: Shima
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D001930:Brain Injuries / Q000209:etiology / Q000473:pathology*; D002540:Cerebral Cortex / Q000378:metabolism*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D010474:Percussion / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D052242:Adiponectin