title: PET imaging for receptor occupancy: meditations on calculation and simplification.
abstract: This invited mini-review briefly summarizes procedures and challenges of measuring receptor occupancy with positron emission tomography. Instead of describing the detailed analytic procedures of in vivo ligand-receptor imaging, the authors provide a pragmatic approach, along with personal perspectives, for conducting positron emission tomography imaging for receptor occupancy, and systematically elucidate the mathematics of receptor occupancy calculations in practical ways that can be understood with elementary algebra. The authors also share insights regarding positron emission tomography imaging for receptor occupancy to facilitate applications for the development of drugs targeting receptors in the central nervous system.
authors.affiliation: Translational Sciences, Global Pharmaceutical R & D, Abbott Laboratories, Abbott Park, IL 60064, USA.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Gerard B
authors.initials: GB
authors.lastname: Fox
keywords: central nervous system; drug development; positron emission tomography; receptor imaging; receptor occupancy
references.citation: J Nucl Med. 2001 May;42(5):755-63
references.pmid: 11337572
references.citation: Nucl Med Biol. 2005 Aug;32(6):585-91
references.pmid: 16026705
references.citation: Comput Methods Programs Biomed. 2008 Dec;92(3):294-8
references.pmid: 18440664
references.citation: Ann Nucl Med. 2006 Nov;20(9):583-8
references.pmid: 17294668
references.citation: Neuroimage. 2010 Feb 15;49(4):2947-57
references.pmid: 19931403
references.citation: J Nucl Med. 2006 Jan;47(1):43-50
references.pmid: 16391186
references.citation: Ann Neurol. 1984 Mar;15(3):217-27
references.pmid: 6609679
references.citation: Neuroimage. 1996 Dec;4(3 Pt 1):153-8
references.pmid: 9345505
references.citation: J Cereb Blood Flow Metab. 1994 May;14(3):453-65
references.pmid: 8163587
references.citation: J Cereb Blood Flow Metab. 2007 Sep;27(9):1533-9
references.pmid: 17519979
references.citation: J Nucl Med. 2006 Jun;47(6):919-28
references.pmid: 16741300
references.citation: Methods. 2002 Jul;27(3):287-99
references.pmid: 12183117
references.citation: J Nucl Med. 2006 Feb;47(2):302-12
references.pmid: 16455637
references.citation: Methods. 2002 Jul;27(3):278-86
references.pmid: 12183116