title: The associations between high-density lipoprotein mean particle size and its fatty acid composition.
abstract: OBJECTIVE
  High-density lipoprotein (HDL) particles are heterogeneous in their composition, structure and size and may differ in conferring protection against coronary artery disease. The aim of this study is to investigate the associations between HDL size and its fatty acid composition.
  
  
  METHODS
  HDL mean particle size from 140 healthy men was detected by dynamic light scattering methodology and fatty acid composition of HDL was determined by gas chromatography.
  
  
  RESULTS
  HDL with smaller size had a higher proportion of saturated fatty acids and lower proportion of unsaturated fatty acids. HDL mean size indicated a negative correlation with palmitic acid (r = -0.17; p < 0.05) and a positive correlation with palmitoleic acid (r = 0.17; p < 0.05), oleic acid (r = 0.23; p < 0.01), arachidonic acid (r = 0.17; p < 0.05) and dihomogamalinoleic acid (r = -0.18; p < 0.05).
  
  
  CONCLUSIONS
  Saturated fatty acids of HDL are inversely assocaited and unsaturated fatty acids are directly associated with HDL mean size.
authors.affiliation: Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy & Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Amirnader
authors.initials: A
authors.lastname: Emami Razavi
authors.forename: Morteza
authors.initials: M
authors.lastname: Pourfarzam
authors.forename: Mohsen
authors.initials: M
authors.lastname: Ani
authors.forename: Gholam Ali
authors.initials: GA
authors.lastname: Naderi
mesh_terms: D000328:Adult; D002849:Chromatography, Gas; D005227:Fatty Acids / Q000032:analysis*; D006801:Humans; D008075:Lipoproteins, HDL / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D055815:Young Adult
chemical_list: D005227:Fatty Acids; D008075:Lipoproteins, HDL