title: Depression-like behavior is dependent on age in male SAMP8 mice.
abstract: Aging is associated with an increased risk of depression in humans. To elucidate the underlying mechanisms of depression and its dependence on aging, here we study signs of depression in male SAMP8 mice. For this purpose, we used the forced swimming test (FST). The total floating time in the FST was greater in SAMP8 than in SAMR1 mice at 9 months of age; however, this difference was not observed in 12-month-old mice, when both strains are considered elderly. Of the two strains, only the SAMP8 animals responded to imipramine treatment. We also applied the dexamethasone suppression test (DST) and studied changes in the dopamine and serotonin (5-HT) uptake systems, the 5-HT2a/2c receptor density in the cortex, and levels of TPH2. The DST showed a significant difference between SAMR1 and SAMP8 mice at old age. SAMP8 exhibits an increase in 5-HT transporter density, with slight changes in 5-HT2a/2c receptor density. In conclusion, SAMP8 mice presented depression-like behavior that is dependent on senescence process, because it differs from SAMR1, senescence resistant strain.
authors.affiliation: Animal Experimentation Unit of Psychology, University of Barcelona, Campus Mundet. Pg. Vall d'Hebron 171. Edifici de Ponent, 08035 Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Pérez-Cáceres
authors.forename: A
authors.initials: A
authors.lastname: Ciudad-Roberts
authors.forename: M T
authors.initials: MT
authors.lastname: Rodrigo
authors.forename: D
authors.initials: D
authors.lastname: Pubill
authors.forename: A
authors.initials: A
authors.lastname: Camins
authors.forename: J
authors.initials: J
authors.lastname: Camarasa
authors.forename: E
authors.initials: E
authors.lastname: Escubedo
authors.forename: M
authors.initials: M
authors.lastname: Pallàs
mesh_terms: D000375:Aging / Q000235:genetics* / Q000523:psychology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001522:Behavior, Animal; D002540:Cerebral Cortex / Q000378:metabolism; D003863:Depression / Q000188:drug therapy / Q000453:epidemiology* / Q000523:psychology*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D007099:Imipramine / Q000627:therapeutic use; D015994:Incidence; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000523:psychology*; D011985:Receptors, Serotonin / Q000378:metabolism; D013550:Swimming / Q000523:psychology; D016896:Treatment Outcome; D014365:Tryptophan Hydroxylase / Q000378:metabolism
chemical_list: D000929:Antidepressive Agents, Tricyclic; D011985:Receptors, Serotonin; C487802:Tph2 protein, mouse; D014365:Tryptophan Hydroxylase; D007099:Imipramine; D004298:Dopamine