title: [Clinical role of lipoprotein-associated phospholipase A2].
abstract: Inflammation plays an important role in origin and progression of atheromatous plaque. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered a biomarker of inflammation and a predictor of vascular events. Lp-PLA2 is an enzyme secreted by leukocytes and associated with circulating lipoproteins and macrophages in atherosclerotic plaques. Lp-PLA2 hydrolizes phospholipids of oxidized low density lipoproteins and generates two proinflammatory mediators, lysophosphatidylcholine and oxidized nonesterified fatty acids, which play a major role in the development of atherosclerotic lesions, myocardial infarction and ischemic stroke. Recently the first publications appeared about selective inhibitor of phospholipase A2 - darapladib as a novel therapeutic approach for the treatment of patients with coronary artery disease. However, first results need to be confirmed by ongoing large long-term randomized clinical trials.
authors.forename: S V
authors.initials: SV
authors.lastname: Miklishanskaia
authors.forename: A A
authors.initials: AA
authors.lastname: Liakishev
authors.forename: V V
authors.initials: VV
authors.lastname: Kukharchuk
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000037:antagonists & inhibitors / Q000378:metabolism; D001547:Benzaldehydes / Q000494:pharmacology; D015415:Biomarkers / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism; D007962:Leukocytes / Q000201:enzymology; D008074:Lipoproteins / Q000378:metabolism; D008244:Lysophosphatidylcholines / Q000378:metabolism; D009203:Myocardial Infarction / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D010091:Oximes / Q000494:pharmacology; D058226:Plaque, Atherosclerotic / Q000209:etiology / Q000378:metabolism; D020521:Stroke / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D035703:Therapies, Investigational; D001713:Biphenyl Compounds; D004048:Diethylamines; D011744:Pyrimidinones; D013440:Sulfides
chemical_list: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D001547:Benzaldehydes; D015415:Biomarkers; D005230:Fatty Acids, Nonesterified; D008074:Lipoproteins; D008244:Lysophosphatidylcholines; D010091:Oximes; C529040:darapladib; D001713:Biphenyl Compounds; D004048:Diethylamines; D011744:Pyrimidinones; D013440:Sulfides