title: 1-hour venous plasma glucose and incident prediabetes and diabetes in Asian indians.
abstract: BACKGROUND
  This study evaluated 1-h plasma glucose (1HrPG) levels during an oral glucose tolerance test (OGTT) in predicting progression to diabetes and prediabetes among individuals with normal glucose tolerance (NGT).
  
  
  METHODS
  After analyzing the electronic records of 32,809 subjects who had undergone an OGTT, we identified 1,179 subjects who had NGT at baseline, defined as fasting plasma glucose (FPG) of < 100 mg/dL and 2-h plasma glucose (2HrPG) of < 140 mg/dL, who had at least one follow-up OGTT. Receiver operating characteristic curves were constructed to derive the optimal 1HrPG values, which were associated with the development of diabetes (FPG of ≥ 126 mg/dL or 2HrPG of ≥ 200 mg/dL) or prediabetes (FPG ≥ 100 to <1 26 mg/dL or 2HrPG of ≥ 140 to < 200 mg/dL) at follow-up in these NGT subjects.
  
  
  RESULTS
  On follow-up, 148 (12.6%) subjects developed diabetes, and 392 (33.2%) developed prediabetes. In those with 1HrPG values ≥ 155 mg/dL, 19.5% converted to diabetes compared with 10% among those with 1HrPG of ≥143 to < 155 mg/dL and 6.6% in those with 1HrPG < 143 mg/dL. Comparative figures for conversion to prediabetes were 52.2% (1HrPG values ≥ 155 mg/dL), 39.3% (1HrPG ≥ 143 to <155 mg/dL), and 26.0% (1HrPG < 143 mg/dL). The time to development of diabetes (mean ± SE) was also significantly shorter among those with 1HrPG values of ≥ 155 mg/dL (9.0±0.3 years) compared with those with 1HrPG ≥ 143 to < 155 mg/dL (10.6 ± 0.5 years) and 1HrPG < 143 mg/dL (11.6 ± 0.2 years).
  
  
  CONCLUSIONS
  Among NGT subjects with elevated 1HrPG values during an OGTT, progression to diabetes and prediabetes is greater, and the rate of progression is also faster.
authors.affiliation: Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases, IDF Centre for Education, Gopalapuram, Chennai, India.
authors.forename: Miranda
authors.initials: M
authors.lastname: Priya
authors.forename: Ranjit Mohan
authors.initials: RM
authors.lastname: Anjana
authors.forename: Faraja S
authors.initials: FS
authors.lastname: Chiwanga
authors.forename: Kuppan
authors.initials: K
authors.lastname: Gokulakrishnan
authors.forename: Mohan
authors.initials: M
authors.lastname: Deepa
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology* / Q000208:ethnology / Q000517:prevention & control; D018450:Disease Progression; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test / Q000379:methods; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007194:India / Q000453:epidemiology / Q000208:ethnology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood* / Q000453:epidemiology* / Q000208:ethnology / Q000517:prevention & control; D011237:Predictive Value of Tests; D012372:ROC Curve; D013997:Time Factors; D044465:White People / Q000706:statistics & numerical data*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human