title: Conjugated and immobilized photosensitizers for combating bacterial infections.
abstract: The technique of photosensitization for eradication of bacterial cells involves the use of molecules called photosesitizers (PSs) which generate reactive oxygen species (ROS) upon illumination with light of a suitable wavelength. ROS can oxidize biological molecules such as proteins, nucleic acids and lipids, which ultimately leads to bacterial cell death. Use of PS-conjugates and immobilized PS can lead to a reduction in the amount of a compound necessary for bacterial cell eradication. In addition, PS-conjugates for delivering photosensitizer molecules are more effective for clinical applications, since the photosensitizers are targeted directly to bacterial cells. This review reports studies and patents that demonstrate the possibility of increasing bacterial cells eradication by using specific and non-specific PS-conjugates such as: PS-antibiotic, PS-polycation (including PS-poly-L-lysine and PS-polyethyleneimine), PS-bacteriophage, PS-IgG and PS-siderophore. Studies and patents describing immobilized PS for drug delivery are also considered.
authors.affiliation: Department of Chemical Engineering and Biotechnology, Ariel University, Ariel 40700, Israel. rivkac@ariel.ac.il
authors.forename: Rivka
authors.initials: R
authors.lastname: Cahan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D001435:Bacteriophages / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D010330:Patents as Topic; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D011073:Polyamines; D000071228:Polyelectrolytes; D011094:Polyethyleneimine / Q000737:chemistry / Q000494:pharmacology; D011107:Polylysine / Q000737:chemistry / Q000494:pharmacology; D017262:Siderophores / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D017319:Photosensitizing Agents; D011073:Polyamines; D000071228:Polyelectrolytes; D011094:Polyethyleneimine; D011107:Polylysine; D017262:Siderophores