title: Population structure in a comprehensive genomic data set on human microsatellite variation.
abstract: Over the past two decades, microsatellite genotypes have provided the data for landmark studies of human population-genetic variation. However, the various microsatellite data sets have been prepared with different procedures and sets of markers, so that it has been difficult to synthesize available data for a comprehensive analysis. Here, we combine eight human population-genetic data sets at the 645 microsatellite loci they share in common, accounting for procedural differences in the production of the different data sets, to assemble a single data set containing 5795 individuals from 267 worldwide populations. We perform a systematic analysis of genetic relatedness, detecting 240 intra-population and 92 inter-population pairs of previously unidentified close relatives and proposing standardized subsets of unrelated individuals for use in future studies. We then augment the human data with a data set of 84 chimpanzees at the 246 loci they share in common with the human samples. Multidimensional scaling and neighbor-joining analyses of these data sets offer new insights into the structure of human populations and enable a comparison of genetic variation patterns in chimpanzees with those in humans. Our combined data sets are the largest of their kind reported to date and provide a resource for use in human population-genetic studies.
authors.affiliation: Department of Biology, Stanford University, Stanford, California 94305, USA. pembertont@med.umanitoba.ca
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Pemberton
authors.forename: Michael
authors.initials: M
authors.lastname: DeGiorgio
authors.forename: Noah A
authors.initials: NA
authors.lastname: Rosenberg
mesh_terms: D000483:Alleles; D000818:Animals; D030541:Databases, Genetic; D056426:Genetic Loci / Q000235:genetics; D014644:Genetic Variation; D005828:Genetics, Population; D015894:Genome, Human / Q000235:genetics*; D023281:Genomics; D005843:Geography; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D002679:Pan troglodytes / Q000235:genetics; D010802:Phylogeny; D011157:Population Dynamics; D015203:Reproducibility of Results; D018401:Sample Size
keywords: population structure; relatives; short tandem repeats
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