title: Duration of migraine is associated with cardiac diastolic dysfunction.
abstract: OBJECTIVE
  Migraine is a common type of headache accompanied or preceded by signs of central and autonomic nervous system dysfunction. Autonomic dysfunction has been suggested to be a potential contributor to impaired cardiac diastolic function. Cardiac diastolic dysfunction is characterized by normal left ventricular contractility but impaired ventricular relaxation. It is a growing clinical entity implicated in morbidity and mortality due to heart failure. The aim of this study was to determine if any relationship exists between migraine and diastolic dysfunction.
  
  
  METHODS
  Migraineurs (N = 55), and age- and sex-matched healthy controls (N = 52) were evaluated by conventional and tissue Doppler echocardiography. Migraine-related disability in the previous 3 months was assessed by the Migraine Disability Assessment questionnaire. Baseline characteristics were recorded, and blood samples were collected.
  
  
  RESULTS
  The groups did not differ in terms of sex or age. The migraine group had higher lipid levels compared with the control group. Diastolic dysfunction was significantly higher among the 30 migraineurs with a history of migraine of 10 years or more compared with the 25 migraineurs with a history of less than 10 years, (P = 0.003). In logistic regression analysis, migraine duration was shown to be an independent predictor of diastolic dysfunction (odds ratio 1.130, 95% confidence interval, P = 0.044).
  
  
  CONCLUSIONS
  Cardiac diastolic dysfunction is associated with migraine. A long history of migraine is an independent predictor of diastolic dysfunction.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Ufuk University, Ankara, Turkey.
authors.forename: Berkay
authors.initials: B
authors.lastname: Ekici
authors.forename: Isin
authors.initials: I
authors.lastname: Unal-Cevik
authors.forename: Ebru
authors.initials: E
authors.lastname: Akgul-Ercan
authors.forename: Gulin
authors.initials: G
authors.lastname: Morkavuk
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yakut
authors.forename: Aycan F
authors.initials: AF
authors.lastname: Erkan
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D017281:Cost of Illness; D015150:Echocardiography, Doppler; D005260:Female; D054144:Heart Failure, Diastolic / Q000150:complications / Q000503:physiopathology*; D006334:Heart Function Tests; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000503:physiopathology*; D020325:Migraine with Aura / Q000150:complications / Q000503:physiopathology; D020326:Migraine without Aura / Q000150:complications / Q000503:physiopathology; D009200:Myocardial Contraction / Q000502:physiology; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Burden of Disease; Headache; Hyperlipidemia; Quality of Life; Risk Factor