title: Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner-Wadsworth-Emmons olefination/cyclisation.
abstract: 4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner-Wadsworth-Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups.
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Glasgow, UK.
authors.forename: Calum W
authors.initials: CW
authors.lastname: Muir
authors.forename: Alan R
authors.initials: AR
authors.lastname: Kennedy
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Redmond
authors.forename: Allan J B
authors.initials: AJ
authors.lastname: Watson
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; D011807:Quinolizines