title: Evidence for reactivation of human herpesvirus 6 in generalized lymphadenopathy in a patient with drug-induced hypersensitivity syndrome.
abstract: The present case provides direct evidence of human herpesvirus 6 reactivation in resected lymph node tissue in a patient with drug-induced hypersensitivity syndrome. This case clearly demonstrates that appropriate pathological evaluation of lymphadenopathy for drug-induced hypersensitivity syndrome, which mimics malignant lymphoma in clinical, radiological, and pathological findings, is required.
authors.affiliation: Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Saraya
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mikoshiba
authors.forename: Harumi
authors.initials: H
authors.lastname: Kamiyama
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yoshizumi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tsuchida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsukagoshi
authors.forename: Taisei
authors.initials: T
authors.lastname: Ishioka
authors.forename: Miho
authors.initials: M
authors.lastname: Terada
authors.forename: Eiichi
authors.initials: E
authors.lastname: Tanabe
authors.forename: Chizuko
authors.initials: C
authors.lastname: Tomioka
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Ishii
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kimura
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Kozawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shiohara
authors.forename: Hajime
authors.initials: H
authors.lastname: Takizawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Goto
mesh_terms: D004342:Drug Hypersensitivity / Q000150:complications*; D005260:Female; D015654:Herpesvirus 6, Human / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D008198:Lymph Nodes / Q000821:virology; D008206:Lymphatic Diseases / Q000473:pathology* / Q000821:virology*; D008875:Middle Aged; D019349:Roseolovirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000821:virology; D014775:Virus Activation
references.citation: Indian J Dermatol Venereol Leprol. 2011 Jan-Feb;77(1):7-15
references.pmid: 21220873
references.citation: Allergol Int. 2006 Mar;55(1):1-8
references.pmid: 17075280
references.citation: Chem Immunol Allergy. 2012;97:122-38
references.pmid: 22613858
references.citation: Cancer. 1959 Jan-Feb;12(1):164-82
references.pmid: 13618867
references.citation: Arch Intern Med. 1995 Nov 27;155(21):2285-90
references.pmid: 7487252
references.citation: Am J Surg Pathol. 1996 Oct;20(10):1279-87
references.pmid: 8827036
references.citation: J Clin Pathol. 1986 Nov;39(11):1224-8
references.pmid: 3793940
references.citation: Br J Dermatol. 2007 Mar;156(3):609-11
references.pmid: 17300272
references.citation: N Engl J Med. 1975 Aug 7;293(6):292-7
references.pmid: 1138181
references.citation: Arch Dermatol. 1998 Sep;134(9):1108-12
references.pmid: 9762023
references.citation: Br J Dermatol. 2007 May;156(5):1083-4
references.pmid: 17381452
references.citation: Am J Med. 2012 Jul;125(7):e9-10
references.pmid: 22727240
references.citation: J Clin Microbiol. 2002 Jul;40(7):2445-51
references.pmid: 12089260