title: Enhanced functional connectivity between putamen and supplementary motor area in Parkinson's disease patients.
abstract: Parkinson's disease (PD) is a surprisingly heterogeneous disorder with symptoms including resting tremor, bradykinesia and rigidity. PD has been associated with abnormal task related brain activation in sensory and motor regions as well as reward related network. Although corticostriatal skeletomotor circuit dysfunction is implicated in the neurobiology of Parkinson's disease, the functional connectivity within this circuit at the resting state is still unclear for PD. Here we utilized resting state functional magnetic resonance imaging to measure the functional connectivity of striatum and motor cortex in 19 patients with PD and 20 healthy controls. We found that the putamen, but not the caudate, exhibited enhanced connectivity with supplementary motor area (SMA), using either the putamen or the SMA as the "seed region". Enhanced SMA-amygdala functional connectivity was also found in the PD group, compared with normal controls. Our findings highlight the key role of hyper-connected putamen-SMC circuit in the pathophysiology of PD.
authors.affiliation: School of Psychology and Center for Studies of Psychological Application, South China Normal University, Guangzhou, China. rongjun.yu@gmail.com
authors.forename: Rongjun
authors.initials: R
authors.lastname: Yu
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Lingling
authors.initials: L
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Xian
authors.initials: X
authors.lastname: Liu
mesh_terms: D000368:Aged; D000679:Amygdala / Q000473:pathology; D001921:Brain / Q000473:pathology; D001931:Brain Mapping; D016022:Case-Control Studies; D003287:Contrast Media / Q000494:pharmacology; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000033:anatomy & histology* / Q000473:pathology; D010300:Parkinson Disease / Q000175:diagnosis / Q000473:pathology*; D011699:Putamen / Q000033:anatomy & histology* / Q000473:pathology; D014202:Tremor
chemical_list: D003287:Contrast Media
references.citation: J Neurol Neurosurg Psychiatry. 2001 Sep;71(3):375-82
references.pmid: 11511714
references.citation: Brain Res. 1995 Oct 2;694(1-2):111-27
references.pmid: 8974634
references.citation: J Neurosci. 2003 Apr 15;23(8):3432-8
references.pmid: 12716951
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: Brain. 2010 May;133(Pt 5):1526-36
references.pmid: 20371508
references.citation: Neuroreport. 2008 Jun 11;19(9):957-60
references.pmid: 18521000
references.citation: Front Syst Neurosci. 2010 May 14;4:13
references.pmid: 20577591
references.citation: Cereb Cortex. 2008 Dec;18(12):2735-47
references.pmid: 18400794
references.citation: Brain. 2001 Mar;124(Pt 3):558-70
references.pmid: 11222456
references.citation: Nat Rev Neurosci. 2007 Sep;8(9):700-11
references.pmid: 17704812
references.citation: Neuroimage. 2011 Mar 1;55(1):204-15
references.pmid: 21126588
references.citation: Ann Neurol. 1992 Aug;32(2):151-61
references.pmid: 1510355
references.citation: Neurosci Lett. 2009 Aug 21;460(1):6-10
references.pmid: 19463891
references.citation: Eur J Neurosci. 2003 Aug;18(4):980-94
references.pmid: 12925024
references.citation: Brain. 2000 Feb;123 ( Pt 2):394-403
references.pmid: 10648446
references.citation: Curr Opin Neurobiol. 2001 Dec;11(6):663-72
references.pmid: 11741015
references.citation: Neuroimage. 2010 Jan 15;49(2):1282-8
references.pmid: 19818409
references.citation: Neuron. 2012 Jun 7;74(5):936-46
references.pmid: 22681696
references.citation: J Psychopharmacol. 1997;11(2):99-106
references.pmid: 9208373
references.citation: Brain. 1996 Dec;119 ( Pt 6):2097-103
references.pmid: 9010013
references.citation: J Neurol. 2005 Feb;252(2):176-82
references.pmid: 15729523
references.citation: Brain Res. 2009 Dec 15;1303:195-206
references.pmid: 19699190
references.citation: Front Syst Neurosci. 2010 Sep 15;4:143
references.pmid: 21206528
references.citation: Hum Brain Mapp. 2011 Sep;32(9):1443-57
references.pmid: 20740649
references.citation: Brain. 2002 Nov;125(Pt 11):2431-45
references.pmid: 12390970
references.citation: J Cereb Blood Flow Metab. 2009 Sep;29(9):1601-8
references.pmid: 19491921
references.citation: Neuroimage. 2005 Jul 1;26(3):912-21
references.pmid: 15955501
references.citation: Brain. 2003 Feb;126(Pt 2):451-61
references.pmid: 12538411
references.citation: Neuroimage. 2011 Aug 1;57(3):938-49
references.pmid: 21609770
references.citation: J Neurophysiol. 1990 Jul;64(1):133-50
references.pmid: 2388061
references.citation: PLoS One. 2011;6(9):e25031
references.pmid: 21949842
references.citation: Mov Disord. 2002 Sep;17(5):867-76
references.pmid: 12360535
references.citation: Science. 1992 Jun 19;256(5064):1692-5
references.pmid: 1609282