title: Serotype distribution of pneumococci isolated from pediatric patients with acute otitis media and invasive infections, and potential coverage of pneumococcal conjugated vaccines.
abstract: A 16-month prospective, descriptive study was conducted on pneumococcal serotype distribution isolated from children with acute otitis media (AOM) and invasive infections (INV). Eighty-nine children with pneumococcal INV and 324 with a first episode of AOM were included. Bacterial pathogens (N = 326) were isolated from the middle-ear fluid of 250 patients. A total of 30 pneumococcal serotypes were identified. Prevalent serotypes were 14, 19A, 9V, 3, 19F, 6A, 23F, and 18C in AOM and 14, 1, 19A, 5, 12F, 6B, and 18C in INV. Potential coverage with PCV10 vaccine would be 46.5 % and 60.7 % for pneumococci involved in AOM and INV, respectively; it would be 71.7 % and 73 % with PCV13. PCV10, conjugated with a Haemophilus protein, would have an immunologic coverage of 39.9 % for AOM vs. 18.5 % with PCV13. However, differences in the prevention of INV were crucial for the decision to include the 13-valent vaccine in the national calendar for children less than two years old in Argentina.
authors.affiliation: Servicio de Microbiología, Hospital de Pediatría, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Vanesa
authors.initials: V
authors.lastname: Reijtman
authors.forename: Sofía
authors.initials: S
authors.lastname: Fossati
authors.forename: Claudia
authors.initials: C
authors.lastname: Hernández
authors.forename: Patricia
authors.initials: P
authors.lastname: Sommerfleck
authors.forename: Patricia
authors.initials: P
authors.lastname: Bernáldez
authors.forename: Mirta
authors.initials: M
authors.lastname: Litterio
authors.forename: Griselda
authors.initials: G
authors.lastname: Berberian
authors.forename: Mabel
authors.initials: M
authors.lastname: Regueira
authors.forename: Horacio
authors.initials: H
authors.lastname: Lopardo
mesh_terms: D000208:Acute Disease; D001118:Argentina / Q000453:epidemiology; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D060085:Coinfection; D005260:Female; D006192:Haemophilus Infections / Q000453:epidemiology; D006193:Haemophilus influenzae; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology / Q000382:microbiology; D010033:Otitis Media / Q000453:epidemiology / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D022242:Pneumococcal Vaccines; D011446:Prospective Studies; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000302:isolation & purification; D014611:Vaccination / Q000706:statistics & numerical data; D018074:Vaccines, Conjugate
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate