title: Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
abstract: The effects of maslinic acid (1), a pentacyclic triterpenoid obtained from Olea europaea, were studied in several tests for nociception in mice. Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia. However, it did not induce motor incoordination in the rotarod test. The topical administration of 1 also reduced the inflammatory phase of the formalin test, indicating that at least some of its effects are mediated peripherally. The present results demonstrate for the first time that maslinic acid induces antinociceptive and antiallodynic effects.
authors.affiliation: Department of Pharmacology, School of Medicine, University of Granada, Avenida de Madrid 11, 18012 Granada, Spain.
authors.forename: Francisco R
authors.initials: FR
authors.lastname: Nieto
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Cobos
authors.forename: José M
authors.initials: JM
authors.lastname: Entrena
authors.forename: Andrés
authors.initials: A
authors.lastname: Parra
authors.forename: Andrés
authors.initials: A
authors.lastname: García-Granados
authors.forename: José M
authors.initials: JM
authors.lastname: Baeyens
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D002211:Capsaicin / Q000627:therapeutic use; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D015394:Molecular Structure; D031658:Olea / Q000737:chemistry*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010147:Pain Measurement; D000069583:Pregabalin; D045442:Rotarod Performance Test; D013997:Time Factors; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D009828:Oleanolic Acid / Q000031:analogs & derivatives
chemical_list: D000700:Analgesics; D002211:Capsaicin; D000069583:Pregabalin; D014315:Triterpenes; D005680:gamma-Aminobutyric Acid; C412811:maslinic acid; D009828:Oleanolic Acid