title: Coreosides A-D, C14-polyacetylene glycosides from the capitula of Coreopsis tinctoria and its anti-inflammatory activity against COX-2.
abstract: Four new C14-polyacetylene glycosides, namely coreosides A-D (1-4), were isolated from the capitula of Coreopsis tinctoria, a Snow chrysanthemum or Snow tea that is used as a folk tea for prevention of cardiovascular disease in southern Xinjiang, China. Coreosides A-D feature a long chain structure as its aglycon with two acetylenes on C-8 and C-10 and two olefinics on C-6 and C-12 sites, which construct a large conjugate system. The structures were elucidated on the basis of spectroscopic evidences and hydrolysis. Compounds 1-4 exhibited significant inhibition against cyclooxygenase-2 at the concentration of 1×10(-6) mol/L, with its IC50 values of 0.22-8.8×10(-2) μmol/L.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shepo
authors.initials: S
authors.lastname: Shi
authors.forename: Mingbo
authors.initials: M
authors.lastname: Zhao
authors.forename: Xingyun
authors.initials: X
authors.lastname: Chai
authors.forename: Pengfei
authors.initials: P
authors.lastname: Tu
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000517:prevention & control; D031945:Coreopsis / Q000737:chemistry*; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D056626:Inflorescence / Q000737:chemistry; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D006027:Glycosides; D010936:Plant Extracts; D053279:Polyynes