title: Phosphoinositide 3-kinase gamma in T cell biology and disease therapy.
abstract: Phosphoinositide 3-kinase gamma (PI3Kγ) kinase activity is important for its signaling functions in T cell development, activation, differentiation, and trafficking. Protection of PI3Kγ knockout mice from disease in multiple autoimmune models suggests that targeting PI3Kγ alone, or in combination with PI3Kδ, could be a promising approach to disease therapy.
authors.affiliation: Janssen Research & Development, LLC, San Diego, California 92121, USA. wleung@its.jnj.com
authors.forename: Wai-Ping
authors.initials: WP
authors.lastname: Fung-Leung
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000378:metabolism; D058544:Class Ib Phosphatidylinositol 3-Kinase / Q000378:metabolism*; D004195:Disease Models, Animal; D051379:Mice; D018345:Mice, Knockout; D058990:Molecular Targeted Therapy; D013601:T-Lymphocytes / Q000201:enzymology / Q000378:metabolism*
chemical_list: D058544:Class Ib Phosphatidylinositol 3-Kinase; C546764:Pik3cg protein, mouse