title: Three-dimensional spectral domain optical coherence tomography in X linked foveal retinoschisis.
abstract: Spectral domain optical coherence tomography (SD-OCT) was performed in two cases of bilateral X linked foveal retinoschisis of different age groups. On fundus examination spoke wheel and honeycomb pattern of cysts were observed along with retinal nerve fibre layer (RNFL) defects. On SD-OCT, schisis was observed in the outer plexiform layer. External limiting membrane disruption was observed in the subfoveal area, along with disruption of outer nuclear layer (ONL) and inner-outer segment junction. Elevation of ONL due to tractional pull of central palisade was a novel observation. Retinoschisis extended beyond the optic disc up to the nasal region. Extracted RNFL tomogram presented an unprecedented visualisation of schisis along 360° of the optic disc. Tractional elevation in the foveal area and schisis involving nasal region, not observed upon clinical examination, was highlighted on SD-OCT. This investigative modality is an important adjunct in the assessment of foveal retinoschisis.
authors.affiliation: Department of Ophthalmology, KG's Medical University, Lucknow, Uttar Pradesh, India. sandeepsaxena2020@yahoo.com
authors.forename: Sandeep
authors.initials: S
authors.lastname: Saxena
authors.lastname: Manisha
authors.forename: Carsten H
authors.initials: CH
authors.lastname: Meyer
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D041441:Retinoschisis / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D055815:Young Adult
references.citation: Hum Mol Genet. 2002 Nov 15;11(24):3097-105
references.pmid: 12417531
references.citation: Arch Ophthalmol. 2008 Jun;126(6):807-11
references.pmid: 18541843
references.citation: Arch Ophthalmol. 1968 Jan;79(1):49-53
references.pmid: 5635090
references.citation: Optom Vis Sci. 2012 May;89(5):678-83
references.pmid: 22407255
references.citation: Am J Ophthalmol. 2010 Jun;149(6):973-978.e2
references.pmid: 20430364
references.citation: Clin Ophthalmol. 2012;6:1563-5
references.pmid: 23055679
references.citation: Surv Ophthalmol. 2004 Mar-Apr;49(2):214-30
references.pmid: 14998693
references.citation: Nat Genet. 1997 Oct;17(2):164-70
references.pmid: 9326935
references.citation: Int Ophthalmol. 2012 Dec;32(6):595-8
references.pmid: 22752678
references.citation: Can J Ophthalmol. 1973 Jul;8(3):385-93
references.pmid: 4742888
references.citation: Arch Ophthalmol. 2002 Jul;120(7):979-84
references.pmid: 12096974
references.citation: Ophthalmology. 2013 Jan;120(1):169-74
references.pmid: 23009889