title: [Relationship of subclinical atherosclerosis indicators to exercise tolerance in patients with coronary heart disease].
abstract: OBJECTIVE
  To study the spread of a number of indicators of subclinical atherosclerosis in patients with coronary heart disease (CHD) and the pattern of their relationship to their functional state and muscle mass.
  
  
  METHODS
  Twenty patients with chronic forms of CHD were examined. Vascular wall stiffness was judged from pulse wave velocity (PWV) along elastic-type vessels, by calculating the carotid-femoral index (CFI). Endothelial function was estimated by endothelium-dependent vasodilation (EDV) in a reactive hyperemia test. Ultrasound scanning of the common carotid artery was used to estimate intima-media thickness. All the patients underwent bicycle ergometry; their exercise tolerance (ET) was determined by the amount of consumed oxygen when the metabolic equivalent (MET) was calculated; the percentages of active cell mass (ACM%) and lean mass (LM%) of total body weight were determined; the levels of total cholesterol, high- and low-density lipoprotein cholesterol, and triglycerides were estimated. A control group comprised 20 matched persons without CHD.
  
  
  RESULTS
  A prognostically unfavorable increase of >12 m/sec in CFI was revealed in 20% of the patients with CHD and in 10% of the controls; endothelial vasomotor dysfunction (EDV < 10%) in 65 and 50%; a more than 0.9-mm increase in 55 and 15%, respectively. A low ET was stated in the majority of patients with abnormal vascular stiffness and endothelial vasomotor dysfunction. The CHD patients with a low ET were found to have significant correlations of CFI with ACM% and LM%, EDV and ACM% and LM%, CFI and EDV. The control patients with a low ET also showed correlations of EDV and ACM% and LM%. There was a correlation of ACM% and LM% with MET in both groups.
  
  
  CONCLUSIONS
  EDV and PWV reflect a more decrease in physical activity and dysadapted functional status than in the degree of subclinical atherosclerosis.
authors.forename: S M
authors.initials: SM
authors.lastname: Noskov
authors.forename: A A
authors.initials: AA
authors.lastname: Zavodchikov
authors.forename: A V
authors.initials: AV
authors.lastname: Evgen'eva
authors.forename: A A
authors.initials: AA
authors.lastname: Lavrukhina
authors.forename: A N
authors.initials: AN
authors.lastname: Chamorovskiĭ
authors.forename: O N
authors.initials: ON
authors.lastname: Prokopenko
authors.forename: V S
authors.initials: VS
authors.lastname: Poletaeva
mesh_terms: D050197:Atherosclerosis / Q000175:diagnosis / Q000503:physiopathology*; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D003327:Coronary Disease / Q000175:diagnosis / Q000503:physiopathology*; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059289:Vascular Stiffness / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*