title: Acute angioedema response to topical 5-fluorouracil therapy.
abstract: This is a case report involving a patient who was treated with topical 5-FU cream and subsequently developed a severe case of angioedema. This case presents the possibility of anaphylaxis to topical 5-FU treatments and/or the interaction with angiotensin converting enzyme inhibitors. To our knowledge there has been no prior reported case of this reaction. We present this unusual case along with a review of the current literature on angioedema.
authors.affiliation: Silver Falls Dermatology, Salem, OR, USA.
authors.forename: Cory
authors.initials: C
authors.lastname: Maughan
authors.forename: William
authors.initials: W
authors.lastname: Lear
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000799:Angioedema / Q000139:chemically induced* / Q000473:pathology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004347:Drug Interactions; D005145:Face / Q000473:pathology; D005472:Fluorouracil / Q000009:adverse effects*; D006225:Hand / Q000473:pathology; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy*; D008297:Male
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil