title: Differences in intrinsic functional organization between dorsolateral prefrontal and posterior parietal cortex.
abstract: The dorsolateral prefrontal and posterior parietal cortex are 2 components of the cortical network controlling attention, working memory, and executive function. Little is known about how the anatomical organization of the 2 areas accounts for their functional specialization. In order to address this question, we examined the strength of intrinsic functional connectivity between neurons sampled in each area by means of cross-correlation analyses of simultaneous recordings from monkeys trained to perform working memory tasks. In both areas, effective connectivity declined as a function of distance between neurons. However, the strength of effective connectivity was higher overall and more localized over short distances in the posterior parietal than the prefrontal cortex. The difference in connectivity strength between the 2 areas could not be explained by differences in firing rate or selectivity for the stimuli and task events, it was present when the fixation period alone was analyzed, and according to simulation results, was consistent with a systematic difference either in the strength or in the relative numbers of shared inputs between neurons. Our results indicate that the 2 areas are characterized by unique intrinsic functional organization, consistent with known differences in their response patterns during working memory.
authors.affiliation: Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: Fumi
authors.initials: F
authors.lastname: Katsuki
authors.affiliation: Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Qi
authors.affiliation: Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: Travis
authors.initials: T
authors.lastname: Meyer
authors.affiliation: Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: Phillip M
authors.initials: PM
authors.lastname: Kostelic
authors.affiliation: Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: Emilio
authors.initials: E
authors.lastname: Salinas
authors.affiliation: Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: Christos
authors.initials: C
authors.lastname: Constantinidis
mesh_terms: D000200:Action Potentials; D000818:Animals; D003198:Computer Simulation; D008253:Macaca mulatta; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008839:Microelectrodes; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*
keywords: cross-correlation; macaque; monkey; neurophysiology; working memory
references.citation: Front Syst Neurosci. 2010 May 14;4:12
references.pmid: 20514341
references.citation: J Comp Neurol. 1989 Sep 22;287(4):422-45
references.pmid: 2477406
references.citation: Front Syst Neurosci. 2011 Aug 24;5:69
references.pmid: 21897811
references.citation: Science. 2010 Jan 29;327(5965):587-90
references.pmid: 20110507
references.citation: J Neurosci Methods. 2005 Mar 15;142(1):27-34
references.pmid: 15652614
references.citation: J Neurophysiol. 1998 Jun;79(6):2919-40
references.pmid: 9636098
references.citation: J Neurophysiol. 1965 Mar;28:229-89
references.pmid: 14283058
references.citation: Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):301-6
references.pmid: 11134516
references.citation: J Neurophysiol. 2000 Jul;84(1):401-14
references.pmid: 10899214
references.citation: Science. 2010 Jan 29;327(5965):584-7
references.pmid: 20110506
references.citation: J Neurophysiol. 2002 Dec;88(6):3487-97
references.pmid: 12466463
references.citation: Eur J Neurosci. 2003 Mar;17(6):1313-8
references.pmid: 12670321
references.citation: Invest Ophthalmol. 1972 May;11(5):302-11
references.pmid: 5028229
references.citation: J Neurophysiol. 2012 Jul;108(1):31-8
references.pmid: 22490554
references.citation: J Neurophysiol. 1974 Nov;37(6):1239-61
references.pmid: 4436698
references.citation: Cogn Affect Behav Neurosci. 2004 Dec;4(4):528-39
references.pmid: 15849895
references.citation: Neural Comput. 1999 Oct 1;11(7):1537-51
references.pmid: 10490937
references.citation: Nature. 1994 Jul 14;370(6485):140-3
references.pmid: 8022482
references.citation: Cereb Cortex. 1991 Jan-Feb;1(1):1-47
references.pmid: 1822724
references.citation: J Neurosci. 2009 Aug 19;29(33):10234-53
references.pmid: 19692598
references.citation: Neurobiol Learn Mem. 2009 Feb;91(2):129-38
references.pmid: 19116173
references.citation: Rev Neurosci. 2006;17(4):415-27
references.pmid: 17139842
references.citation: Nat Neurosci. 2002 Jul;5(7):671-6
references.pmid: 12068302
references.citation: J Neurosci. 1998 Feb 1;18(3):1161-70
references.pmid: 9437036
references.citation: PLoS Comput Biol. 2012;8(3):e1002408
references.pmid: 22457608
references.citation: Trends Neurosci. 2001 Aug;24(8):455-63
references.pmid: 11476885
references.citation: Nat Neurosci. 2002 Feb;5(2):175-80
references.pmid: 11802172
references.citation: Curr Biol. 2007 Jul 3;17(13):R496-500
references.pmid: 17610826
references.citation: Biol Cybern. 1987;57(6):403-14
references.pmid: 3435728
references.citation: Science. 2003 Jan 3;299(5603):81-6
references.pmid: 12511644
references.citation: Nat Neurosci. 2011 Jun 27;14(7):811-9
references.pmid: 21709677
references.citation: Nat Neurosci. 2012 Jul 22;15(8):1160-6
references.pmid: 22820465
references.citation: J Comp Neurol. 1989 Aug 15;286(3):353-75
references.pmid: 2768563
references.citation: Front Integr Neurosci. 2012 May 03;6:17
references.pmid: 22563310
references.citation: J Neurosci. 1996 Aug 15;16(16):5154-67
references.pmid: 8756444
references.citation: J Physiol. 1962 Jan;160:106-54
references.pmid: 14449617
references.citation: J Neurophysiol. 1998 Dec;80(6):3345-51
references.pmid: 9862930
references.citation: J Neurophysiol. 1995 Dec;74(6):2379-400
references.pmid: 8747200
references.citation: Nature. 1993 Jun 17;363(6430):623-5
references.pmid: 8510752
references.citation: Annu Rev Neurosci. 2004;27:419-51
references.pmid: 15217339
references.citation: J Comp Neurol. 1993 Dec 15;338(3):360-76
references.pmid: 8113445
references.citation: Neural Comput. 1999 Oct 1;11(7):1527-35
references.pmid: 10490936
references.citation: J Physiol. 2002 May 15;541(Pt 1):245-60
references.pmid: 12015433
references.citation: Nature. 1995 Nov 16;378(6554):281-4
references.pmid: 7477347
references.citation: Neuroimage. 2002 Feb;15(2):447-53
references.pmid: 11798278
references.citation: Cereb Cortex. 2002 Aug;12(8):866-76
references.pmid: 12122035
references.citation: Annu Rev Neurosci. 2010;33:1-21
references.pmid: 20192813
references.citation: J Neurophysiol. 2000 Jul;84(1):301-10
references.pmid: 10899205
references.citation: Biophys J. 1967 Jul;7(4):419-40
references.pmid: 4292792
references.citation: J Neurosci. 2008 Nov 26;28(48):12591-603
references.pmid: 19036953
references.citation: J Neurophysiol. 2001 Nov;86(5):2266-75
references.pmid: 11698517
references.citation: J Neurophysiol. 1996 Aug;76(2):1352-5
references.pmid: 8871242
references.citation: Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2596-600
references.pmid: 14983054
references.citation: Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6424-9
references.pmid: 17404214
references.citation: Nature. 1997 Apr 10;386(6625):608-11
references.pmid: 9121584
references.citation: Nat Neurosci. 2012 Jan 15;15(2):315-20
references.pmid: 22246435
references.citation: Neural Comput. 1997 Jul 1;9(5):971-83
references.pmid: 9188190
references.citation: Science. 1971 Aug 13;173(3997):652-4
references.pmid: 4998337
references.citation: J Neurophysiol. 1989 Feb;61(2):331-49
references.pmid: 2918358
references.citation: Nat Neurosci. 2013 Jan;16(1):98-104
references.pmid: 23242309
references.citation: Nature. 1998 Jun 11;393(6685):577-9
references.pmid: 9634233
references.citation: Somatosens Mot Res. 1993;10(3):245-62
references.pmid: 8237213
references.citation: J Neurosci. 2012 Mar 7;32(10):3499-515
references.pmid: 22399773
references.citation: J Neurophysiol. 2012 Jul;108(2):595-609
references.pmid: 22496534
references.citation: J Neurosci. 2000 Aug 15;20(16):6193-209
references.pmid: 10934269
references.citation: J Neurosci. 1996 Mar 1;16(5):1922-35
references.pmid: 8774459
references.citation: Annu Rev Neurosci. 2001;24:167-202
references.pmid: 11283309
references.citation: J Neurosci. 2010 Mar 3;30(9):3227-38
references.pmid: 20203182
references.citation: Biophys J. 1970 Sep;10(9):876-900
references.pmid: 4322240
references.citation: Cereb Cortex. 2011 Jun;21(6):1254-72
references.pmid: 21045004
references.citation: Cereb Cortex. 2000 Sep;10(9):910-23
references.pmid: 10982751
references.citation: J Neurophysiol. 2007 Sep;98(3):1733-50
references.pmid: 17596412
references.citation: Nature. 2007 Aug 16;448(7155):802-6
references.pmid: 17700699
references.citation: J Comp Neurol. 1995 Aug 14;359(1):131-43
references.pmid: 8557842
references.citation: Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):883-90
references.pmid: 9448255
references.citation: J Neurosci. 2001 May 15;21(10):3646-55
references.pmid: 11331394
references.citation: Trends Cogn Sci. 2007 Jan;11(1):30-6
references.pmid: 17134935
references.citation: J Neurosci. 2001 Mar 1;21(5):1676-97
references.pmid: 11222658
references.citation: Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7721-6
references.pmid: 9636217
references.citation: J Neurosci. 2000 Sep 15;20(18):RC95
references.pmid: 10974092
references.citation: J Neurosci. 1993 Apr;13(4):1460-78
references.pmid: 8463829
references.citation: J Neurophysiol. 2000 Mar;83(3):1733-50
references.pmid: 10712493
references.citation: Cogn Affect Behav Neurosci. 2004 Dec;4(4):444-65
references.pmid: 15849890
references.citation: Nature. 1998 Jan 29;391(6666):481-4
references.pmid: 9461214
references.citation: J Neurosci. 2011 Apr 27;31(17):6266-76
references.pmid: 21525266
references.citation: J Neurophysiol. 1989 May;61(5):900-17
references.pmid: 2723733
references.citation: Neural Comput. 2009 Jan;21(1):188-215
references.pmid: 19431282
references.citation: Front Neuroanat. 2011 Feb 10;5:2
references.pmid: 21347276
references.citation: Science. 1993 Apr 2;260(5104):47-52
references.pmid: 8465199