title: Effect of ¹⁸F-FDG administration on measurements of bone mineral density and body composition by dual-energy X-ray absorptiometry.
abstract: The purpose of this study was to determine whether antecedent administration of ¹⁸F-fluorodeoxyglucose (FDG) used in positron emission tomography (PET) scanning results in corruption of bone mineral density (BMD) and body composition measured by dual-energy X-ray absorptiometry (DXA) system. DXA measurements of BMD and body composition had been performed twice, before and after ¹⁸F-FDG PET scan in 30 patients. The comparison of pre-values and post-values of all BMD values showed a decrease after the injection. However, only the decrease of whole-body BMD (WB-BMD) was statistically significant (p < 0.05). Whole-body fat mass had increased and whole-body lean body mass had decreased after the injection of ¹⁸F-FDG, and these were statistically significant (p < 0.05). There is statistically significant correlation between the injected ¹⁸F-FDG dose and a decrease of WB-BMD (r = -0.405; p < 0.05). The findings of this study suggest that when both ¹⁸F-FDG PET and DXA measurements for whole-body composition are performed in close-time proximity, ¹⁸F-FDG PET scans should follow the DXA measurement. Otherwise, BMD measurements of total femur or lumbar spine could be followed by ¹⁸F-FDG PET in close-time proximity.
authors.affiliation: Department of Nuclear Medicine, Wonkwang University School of Medicine, Iksan, Jeollabuk-do, Republic of Korea; Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Jeollabuk-do, Republic of Korea.
authors.forename: Dae-Weung
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Wonkwang University School of Medicine, Iksan, Jeollabuk-do, Republic of Korea.
authors.forename: Woo Hyoung
authors.initials: WH
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Wonkwang University School of Medicine, Iksan, Jeollabuk-do, Republic of Korea.
authors.forename: Myoung Hyoun
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Wonkwang University School of Medicine, Iksan, Jeollabuk-do, Republic of Korea.
authors.forename: Seong Su
authors.initials: SS
authors.lastname: Kim
authors.affiliation: Department of Radiology, Wonkwang University School of Medicine, Iksan, Jeollabuk-do, Republic of Korea.
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Mo
authors.affiliation: Department of Nuclear Medicine, Wonkwang University School of Medicine, Iksan, Jeollabuk-do, Republic of Korea.
authors.forename: Chun Ho
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Wonkwang University School of Medicine, Iksan, Jeollabuk-do, Republic of Korea; Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Jeollabuk-do, Republic of Korea. Electronic address: akaxan@naver.com.
authors.forename: Chang Guhn
authors.initials: CG
authors.lastname: Kim
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D001823:Body Composition; D015519:Bone Density / Q000502:physiology*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004305:Dose-Response Relationship, Drug; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging* / Q000378:metabolism; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics; D015203:Reproducibility of Results
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F-FDG; Body composition; DXA; bone mineral density