title: Surprisingly low seroprevalence of Burkholderia pseudomallei in exposed healthy adults in the Darwin region of tropical Australia where melioidosis is highly endemic.
abstract: In the Darwin region of Australia where melioidosis is highly endemic, only 11/354 (3%) healthy residents were seropositive by indirect hemagglutination assay, despite extensive exposure to Burkholderia pseudomallei. None developed melioidosis, but some described a prior self-limiting illness. This seropositivity rate is much lower than that seen in northeast Thailand, where melioidosis is similarly highly endemic, potentially reflecting important differences between these two locations in the epidemiology of melioidosis.
authors.affiliation: Emergency Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
authors.forename: Gemma L
authors.initials: GL
authors.lastname: James
authors.forename: Ben
authors.initials: B
authors.lastname: Delaney
authors.forename: Linda
authors.initials: L
authors.lastname: Ward
authors.forename: Kevin
authors.initials: K
authors.lastname: Freeman
authors.forename: Mark
authors.initials: M
authors.lastname: Mayo
authors.forename: Bart J
authors.initials: BJ
authors.lastname: Currie
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001315:Australia / Q000453:epidemiology; D016957:Burkholderia pseudomallei / Q000276:immunology*; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D008297:Male; D008554:Melioidosis / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial
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