title: Combination therapy of voriconazole and terbinafine for disseminated fusariosis: case report and literature review.
abstract: Fusarium spp. cause a broad spectrum of infection and are relatively resistant to most antifungal agents, leading to unfavorable prognosis, especially in immunocompromised patients. Several reports have shown synergism among amphotericin B, voriconazole (VRC), terbinafine (TRB), and other antifungal agents in vitro, but the most efficacious combination remains to be elucidated. We report the first case of disseminated Fusarium solani infection successfully treated by combination therapy of VRC and TRB accompanied by surgical resection of endocardial lesions. We also review 15 case reports of combination antifungal therapy for fusariosis and 6 case reports of Fusarium endocarditis.
authors.affiliation: Department of Hematology, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, Japan, s-inano@kitano-hp.or.jp.
authors.forename: Shojiro
authors.initials: S
authors.lastname: Inano
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kimura
authors.forename: Jun
authors.initials: J
authors.lastname: Iida
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Arima
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D060585:Fusariosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D000077291:Terbinafine; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D011743:Pyrimidines; D014230:Triazoles; D000077291:Terbinafine; D065819:Voriconazole