title: The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats.
abstract: BACKGROUND
  Diabetes has become the next most widespread disease after cancer. Recent studies have found that diabetes and moderate to severe vitamin D deficiency are associated with reduced bone mineral content; therefore administration of vitamin D may correct these conditions. The purpose of this research is to compare the effect of vitamin D administration on bone to implant contact in diabetic rats with control group.
  
  
  METHODS
  In this randomized placebo-controlled trial, 48 Wistar rats were rendered diabetic (130≤ blood sugar ≤200 mg/dl) by IV injection of 35 mg/kg Alloxan. Implants were inserted in tibial bone; Then rats were divided into study and control groups and received oral vitamin D3 (160 IU) or placebo respectively for one week. Bone to implant contact value was measured under light microscope at 3 and 6 weeks.
  
  
  RESULTS
  Analysis of data indicated that vitamin D had no significant effect on bone to implant contact (BIC). At 3 weeks, the control group (n = 5) reported BIC level at 44 ± 19 and study group (n = 7) at 57 ± 20. At 6 weeks, the control group (n = 5) reported BIC level at 70 ± 29, and study group (n = 10) at 65 ± 22. Twenty one samples were missed because of death or incorrect lab processes.
  
  
  CONCLUSIONS
  It seems that vitamin D supplement has no significant effect on BIC in 130 mg/dL ≤ blood sugar ≤200 mg/dL (P = 0.703) andwas also not time dependent (P = 0.074).
authors.affiliation: Torabinejad Dental Research Center, Department of Endodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Akhavan
authors.forename: Zahra
authors.initials: Z
authors.lastname: Noroozi
authors.forename: Amir Abbas
authors.initials: AA
authors.lastname: Shafiei
authors.forename: Abbas
authors.initials: A
authors.lastname: Haghighat
authors.forename: Gholam Reza
authors.initials: GR
authors.lastname: Jahanshahi
authors.forename: Sayed Behrouz
authors.initials: SB
authors.lastname: Mousavi
keywords: Aloxan; bone-implant contact; type 2 diabetes; vitamin D
references.citation: Clin Oral Implants Res. 2007 Jun;18 Suppl 3:97-113
references.pmid: 17594374
references.citation: Mayo Clin Proc. 2006 Mar;81(3):353-73
references.pmid: 16529140
references.citation: Clin Oral Implants Res. 2012 Oct;23(10):1187-92
references.pmid: 22092360
references.citation: Clin Oral Implants Res. 2012 Nov;23(11):1308-13
references.pmid: 22151621
references.citation: Am J Clin Nutr. 1994 May;59(5):1083-7
references.pmid: 8172095
references.citation: N Engl J Med. 2007 Jul 19;357(3):266-81
references.pmid: 17634462
references.citation: Endocrinology. 1991 Dec;129(6):3269-73
references.pmid: 1659526
references.citation: Exp Diabetes Res. 2012;2012:302682
references.pmid: 22645603
references.citation: J Ethnopharmacol. 2006 Nov 3;108(1):109-15
references.pmid: 16759828
references.citation: Physiol Rev. 1981 Oct;61(4):914-73
references.pmid: 6117094
references.citation: Diabetes Res Clin Pract. 2010 Apr;88(1):e7-9
references.pmid: 20138383
references.citation: Diabet Med. 1988 Jul-Aug;5(5):423-8
references.pmid: 2970913
references.citation: Clin Endocrinol (Oxf). 2000 May;52(5):575-80
references.pmid: 10792336
references.citation: Fundam Clin Pharmacol. 2008 Dec;22(6):657-66
references.pmid: 19049670
references.citation: Diabetologia. 2010 Oct;53(10):2112-9
references.pmid: 20596692
references.citation: Acta Endocrinol (Copenh). 1984 Apr;105(4):528-33
references.pmid: 6144227
references.citation: Int J Oral Maxillofac Implants. 2000 Nov-Dec;15(6):811-8
references.pmid: 11151579
references.citation: J Clin Endocrinol Metab. 2007 Jun;92(6):2130-5
references.pmid: 17426097
references.citation: Diabetes Metab Res Rev. 2009 Jul;25(5):417-9
references.pmid: 19565622
references.citation: Diabetes Care. 2001 Aug;24(8):1496
references.pmid: 11473093
references.citation: Physiol Res. 2001;50(6):537-46
references.pmid: 11829314
references.citation: Diabet Med. 2003 Sep;20(9):693-702
references.pmid: 12925046
references.citation: Med Oral Patol Oral Cir Bucal. 2007 Jan 01;12(1):E38-43
references.pmid: 17195826
references.citation: J Musculoskelet Neuronal Interact. 2006 Oct-Dec;6(4):338-40
references.pmid: 17185814
references.citation: J Prosthodont. 2009 Aug;18(6):473-8
references.pmid: 19486459
references.citation: Clin Oral Implants Res. 2006 Oct;17(5):587-99
references.pmid: 16958701
references.citation: Int J Oral Maxillofac Implants. 2008 Mar-Apr;23(2):237-46
references.pmid: 18548919
references.citation: Braz Dent J. 2004;15(2):87-92
references.pmid: 15776188