title: Conservative therapeutic approach to corrosive poisonings in adults.
abstract: BACKGROUND
  In this study, we assess the effectiveness of a conservative therapeutic treatment of acute corrosive poisonings in adults, and we define therapeutic protocols based on clinical and endoscopic criteria.
  
  
  METHODS
  We analyzed clinical records of patients with acute corrosive poisonings who were hospitalized and treated at the Toxicology Clinic at the University of Skopje, Republic of Macedonia, during a 5-year period (2006-2010). A total of 481 patients' records with cases of acute corrosive poisonings were analyzed. There were 317 female (65.9 %) and 164 male (34.1 %) patients. The purpose of the therapy in the cases of acute corrosive poisonings is to prevent perforation as well as progressive fibrosis and stenosis of the esophagus and stomach. Therapeutic approach mainly consists of proton pump inhibitors, H(2) blockers, antibiotics, and intensive hyperalimentation. There are different opinions regarding conservative treatment of acute corrosive poisonings in adults.
  
  
  CONCLUSIONS
  Based on our study of corrosive poisonings of adults, we propose a list of optimal treatment recommendations.
authors.affiliation: Toxicology Clinic, Clinical Center, School of Medicine, University Ss Cyril and Metodius, Skopje, Republic of Macedonia. toksikourgentna@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Chibishev
authors.forename: Z
authors.initials: Z
authors.lastname: Pereska
authors.forename: N
authors.initials: N
authors.lastname: Simonovska
authors.forename: V
authors.initials: V
authors.lastname: Chibisheva
authors.forename: M
authors.initials: M
authors.lastname: Glasnovic
authors.forename: L T
authors.initials: LT
authors.lastname: Chitkushev
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000628:therapy*; D002424:Caustics / Q000506:poisoning*; D016145:Endoscopy, Digestive System; D004940:Esophageal Stenosis / Q000139:chemically induced / Q000628:therapy; D005260:Female; D005355:Fibrosis / Q000601:surgery; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D013270:Stomach / Q000293:injuries / Q000473:pathology / Q000601:surgery; D015599:Trauma Severity Indices; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002424:Caustics; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors
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