title: Genetic susceptibility to West Nile virus and dengue.
abstract: This article focuses on the host genetic predisposition to 2 viruses, West Nile virus and dengue virus, which belong to the genus Flavivirus. Although by definition these viruses have shared characteristics (e.g. similar size, single stranded, RNA viruses, both transmitted by the bite from an infected mosquito), they differ greatly in epidemiology and clinical manifestations. The text below not only summarizes the genetic factors that predispose to complications of these 2 important flaviviruses, but also illustrates the challenges in determining the genomic basis for complications to these viruses.
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ont., Canada. loebm@mcmaster.ca
authors.forename: M
authors.initials: M
authors.lastname: Loeb
mesh_terms: D000483:Alleles; D000818:Animals; D003715:Dengue / Q000235:genetics* / Q000821:virology*; D003716:Dengue Virus; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D023281:Genomics; D006680:HLA Antigens / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D051379:Mice; D011110:Polymorphism, Genetic; D014901:West Nile Fever / Q000235:genetics* / Q000821:virology*; D014902:West Nile virus
chemical_list: D006680:HLA Antigens