title: Endocrine evaluation after an intra-articular therapeutic dosage of dexamethasone in horses.
abstract: This study investigated whether a single intra-articular administration (IA) of dexamethasone (DEX) in horses at therapeutic dosage could exert a systemic effect by influencing the hypothalamic-pituitary-adrenal axis activity as a consequence of (limited) absorption and systemic distribution. The results indicated that DEX was detectable in urine collected 12-48 h after IA administration and that injection was accompanied by a reduced urine excretion of cortisol, 6β-hydroxycortisol (6βOHF) and two other metabolites of cortisol lasting up to 48 h post-DEX administration. The systemic effects in horses treated with DEX by IA route are similar to those that typically occur with short-term treatment including the reduction in urinary cortisol concentration.
authors.affiliation: Dipartimento di Biomedicina comparata e Alimentazione, Università di Padova, Legnaro, Padova, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Capolongo
authors.forename: G
authors.initials: G
authors.lastname: Gallina
authors.forename: M
authors.initials: M
authors.lastname: Fidani
authors.forename: F
authors.initials: F
authors.lastname: Baia
authors.forename: C
authors.initials: C
authors.lastname: Montesissa
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002853:Chromatography, Liquid; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D006736:Horses / Q000097:blood* / Q000652:urine*; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000097:blood / Q000652:urine; D007270:Injections, Intra-Articular; D008297:Male; D011863:Radioimmunoassay / Q000662:veterinary; D053719:Tandem Mass Spectrometry
chemical_list: D000893:Anti-Inflammatory Agents; C001380:6 beta-hydroxycortisol; D003907:Dexamethasone; D006854:Hydrocortisone