title: DISC1 genetics, biology and psychiatric illness.
abstract: Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.
authors.affiliation: The Centre for Molecular Medicine at the Medical Research Council Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
authors.forename: Pippa A
authors.initials: PA
authors.lastname: Thomson
authors.forename: Elise L V
authors.initials: EL
authors.lastname: Malavasi
authors.forename: Ellen
authors.initials: E
authors.lastname: Grünewald
authors.forename: Dinesh C
authors.initials: DC
authors.lastname: Soares
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Borkowska
authors.forename: J Kirsty
authors.initials: JK
authors.lastname: Millar
keywords: DISC1; depression; genetics; neural pathways; schizophrenia
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