title: The role of CD200-CD200R in tumor immune evasion.
abstract: CD200 is a cell membrane protein that interacts with CD200 receptor (CD200R) of myeloid lineage cells. During tumor initiation and progression, CD200-positive tumor cells can interact with M1 and M2 macrophages through CD200-CD200R-compex, and downregulate IL-10 and IL-12 productions secreted primarily by M2 and M1 macrophages, respectively. In the tumor microenvironment, IL-10 inhibits the activation of cytotoxic T lymphocytes (CTL), while IL-12 enhances CTL activation. In this paper, we used a system approach to determine the combined effect of CD200-CD200R interaction on tumor proliferation by developing a mathematical model. We demonstrate that blocking CD200 on tumor cells may have opposite effects on tumor proliferation depending on the "affinity" of the macrophages to form the CD200-CD200R-complex with tumor cells. Our results help understanding the complexities of tumor microenvironment.
authors.affiliation: Mathematical Biosciences Institute, The Ohio State University, Columbus, OH 43210, USA. kangling.am95g@nctu.edu.tw
authors.forename: Kang-Ling
authors.initials: KL
authors.lastname: Liao
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Bai
authors.forename: Avner
authors.initials: A
authors.lastname: Friedman
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D049109:Cell Proliferation; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D018664:Interleukin-12 / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D018448:Models, Immunological; D009363:Neoplasm Proteins / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D064446:Orexin Receptors; D011956:Receptors, Cell Surface / Q000276:immunology*; D019139:Tumor Escape / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D000954:Antigens, Surface; C477337:CD200R1 protein, human; C508609:IL10 protein, human; D009363:Neoplasm Proteins; D064446:Orexin Receptors; D011956:Receptors, Cell Surface; D016753:Interleukin-10; D018664:Interleukin-12; C042739:antigens, CD200