title: Preoperative HDL-C Predicts Later Cardiovascular Events after Abdominal Aortic Aneurysm Surgery.
abstract: OBJECTIVE
  To determine the predictive value of serum lipid levels on the development of later cardiovascular events after abdominal aortic aneurysm (AAA) surgery.
  
  
  METHODS
  A total of 101 patients under 70 undergoing an elective AAA surgery were divided into the following two groups: 1) those who developed later cardiovascular events after AAA surgery, including cerebral infarction (n = 4), catheter intervention (PCI) or surgery for coronary artery disease (CAD) (n = 9) and other vascular disease. (CVE group; n = 19); 2) those without later events (NoCVE group: n = 82). Preoperative atherosclerotic risk factors including serum lipid levels were subjected to univariate and multivariate analysis.
  
  
  RESULTS
  The CVE group showed a significantly lower high-density lipoprotein cholesterol (HDL-C) level (32.9 ± 6.6 vs 41.6 ± 12.1 mg/dL; p <0.001), higher low-density lipoprotein cholesterol (LDL-C) / HDL-C ratio (4.30 ± 1.01 vs 3.24 ± 1.15; p = 0.001), and higher prevalence of mild CAD (without an indication of PCI) (p = 0.029) preoperatively. Cox hazard analysis indicated that preexistent mild CAD (hazard ratio 4.70) and preoperative HDL-C <35 mg/dL (hazard ratio 3.07) were significant predictors for later cardiovascular events after AAA surgery.
  
  
  CONCLUSIONS
  Patients at high risk for later cardiovascular events should require a careful follow-up and may also require an aggressive lipid-modifying therapy.
authors.affiliation: Division of Cardiovascular Surgery, Aishin Memorial Hospital, Sapporo, Hokkaido, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Takahashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Wakamatsu
authors.forename: Kouji
authors.initials: K
authors.lastname: Ishii
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kanaoka
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Gohda
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Sasaki
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Matsui
keywords: abdominal aortic aneurysm; cardiovascular events; dyslipidemia
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