title: Translational Genomic Research: Protocol Development and Initial Outcomes following SNP Testing for Colon Cancer Risk.
abstract: Although single nucleotide polymorphism (SNP) testing for disease susceptibility is commercially available, translational studies are necessary to understand how to communicate genomic information and potential implications for public health. We explored attitudes about and initial responses to genomic testing for colon cancer risk. Following development of the educational materials, we offered testing for three colon cancer SNPs in a pilot study with primary care patients. Participants completed pre- and post-test sessions and interviews. We analyzed interview transcripts with qualitative software using thematic analysis. All 20 participants opted for SNP testing. Qualitative analysis identified several themes: Motivations for SNP Testing, Before/After: Meaning of Results, Emotional Responses to SNP Results and Genomic Literacy/ Information Delivery. Results demonstrate that individuals will pursue SNP testing in the context of pre and post-test education. SNP results may influence health behaviors like healthy eating and exercise yet did not appear to impact colon cancer screening intentions.
authors.affiliation: Fisher Center for Familial Cancer Research, Lombardi Comprehensive Cancer Center, Georgetown University.
authors.forename: Rachel
authors.initials: R
authors.lastname: Nusbaum
authors.forename: Kara-Grace
authors.initials: KG
authors.lastname: Leventhal
authors.forename: Gillian W
authors.initials: GW
authors.lastname: Hooker
authors.forename: Beth N
authors.initials: BN
authors.lastname: Peshkin
authors.forename: Morgan
authors.initials: M
authors.lastname: Butrick
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Salehizadeh
authors.forename: William
authors.initials: W
authors.lastname: Tuong
authors.forename: Susan
authors.initials: S
authors.lastname: Eggly
authors.forename: Jeena
authors.initials: J
authors.lastname: Mathew
authors.forename: David
authors.initials: D
authors.lastname: Goerlitz
authors.forename: Peter G
authors.initials: PG
authors.lastname: Shields
authors.forename: Marc D
authors.initials: MD
authors.lastname: Schwartz
authors.forename: Kristi D
authors.initials: KD
authors.lastname: Graves
references.citation: Genet Med. 2009 Aug;11(8):570-4
references.pmid: 19478683
references.citation: Res Nurs Health. 2000 Jun;23(3):246-55
references.pmid: 10871540
references.citation: Public Health Genomics. 2011;14(4-5):279-89
references.pmid: 20407217
references.citation: Health Psychol. 2011 Sep;30(5):525-35
references.pmid: 21534672
references.citation: Genet Med. 2011 Feb;13(2):131-9
references.pmid: 21233721
references.citation: Hum Mol Genet. 2008 Dec 1;17(23):3720-7
references.pmid: 18753146
references.citation: Public Health Genomics. 2012;15(1):22-30
references.pmid: 21654153
references.citation: Ann Behav Med. 2010 Oct;40(2):127-37
references.pmid: 20532842
references.citation: Clin Genet. 2011 Nov;80(5):407-14
references.pmid: 21696382
references.citation: BMC Med Ethics. 2011 Jun 14;12:11
references.pmid: 21672210
references.citation: N Engl J Med. 2008 Jan 10;358(2):105-7
references.pmid: 18184955
references.citation: J Genet Couns. 2010 Aug;19(4):387-401
references.pmid: 20352309
references.citation: PLoS Med. 2006 Oct;3(10):e374
references.pmid: 17020404
references.citation: JAMA. 2011 Dec 7;306(21):2376-7
references.pmid: 22147382
references.citation: N Engl J Med. 2011 Sep 15;365(11):1033-41
references.pmid: 21916641
references.citation: Am J Hum Genet. 2008 Mar;82(3):593-9
references.pmid: 18319070
references.citation: Genet Med. 2006 Jul;8(7):448-50
references.pmid: 16845278
references.citation: N Engl J Med. 2010 Jul 8;363(2):166-76
references.pmid: 20647212
references.citation: Nat Genet. 2007 Aug;39(8):984-8
references.pmid: 17618284
references.citation: J Genet Couns. 2012 Jun;21(3):423-32
references.pmid: 22180182
references.citation: BMJ. 2001 Apr 28;322(7293):1056-9
references.pmid: 11325776
references.citation: Eur J Hum Genet. 2012 Aug;20(8):811-6
references.pmid: 22333900
references.citation: Eur J Hum Genet. 2011 Dec;19(12):1213-7
references.pmid: 21731059
references.citation: Ann Fam Med. 2004 Nov-Dec;2(6):583-94
references.pmid: 15576545
references.citation: Hum Mol Genet. 2011 Oct 15;20(R2):R132-41
references.pmid: 21828075
references.citation: Genet Med. 2010 Sep;12(9):556-66
references.pmid: 20717041
references.citation: Health Expect. 2007 Dec;10(4):321-36
references.pmid: 17986069
references.citation: J Genet Couns. 1997 Mar;6(1):21-43
references.pmid: 11660391
references.citation: Patient Educ Couns. 2003 Jul;50(3):247-53
references.pmid: 12900094
references.citation: Am J Bioeth. 2009;9(6-7):3-10
references.pmid: 19998099
references.citation: Psychol Health. 2012;27(4):430-44
references.pmid: 21660870
references.citation: Genet Med. 2010 May;12(5):279-88
references.pmid: 20474084
references.citation: Public Health Genomics. 2012;15(1):11-21
references.pmid: 21720148
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):458-66
references.pmid: 17372241
references.citation: Nat Genet. 2008 Jan;40(1):26-8
references.pmid: 18084292
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Jul;18(7):1953-61
references.pmid: 19567511
references.citation: Annu Rev Genomics Hum Genet. 2010;11:427-46
references.pmid: 20690815
references.citation: Soc Sci Med. 2006 Mar;62(6):1360-8
references.pmid: 16162383
references.citation: Med Decis Making. 2007 Sep-Oct;27(5):681-95
references.pmid: 17873256
references.citation: J Clin Oncol. 2010 Feb 10;28(5):893-901
references.pmid: 20065170
references.citation: N Engl J Med. 2011 Feb 10;364(6):524-34
references.pmid: 21226570
references.citation: J Community Genet. 2010 Sep;1(3):101-106
references.pmid: 21475669
references.citation: Nat Genet. 2011 Jun;43(6):513-8
references.pmid: 21614091
references.citation: J Genet Couns. 2012 Jun;21(3):413-22
references.pmid: 22278220
references.citation: Med Decis Making. 2011 Nov-Dec;31(6):828-38
references.pmid: 22067431
references.citation: Cochrane Database Syst Rev. 2010 Oct 06;(10):CD007275
references.pmid: 20927756
references.citation: Genet Med. 2012 Jul;14(7):681-7
references.pmid: 22481132
references.citation: Gastroenterology. 2010 Nov;139(5):1677-85, 1685.e1-8
references.pmid: 20659471
references.citation: Am J Prev Med. 2010 May;38(5):556-65
references.pmid: 20409503
references.citation: J Health Psychol. 2001 Jan;6(1):47-59
references.pmid: 22049237
references.citation: Health Expect. 2001 Jun;4(2):99-108
references.pmid: 11359540
references.citation: Nat Genet. 2008 Aug;40(8):939-42
references.pmid: 18665132
references.citation: J Genet Couns. 2010 Aug;19(4):315-27
references.pmid: 20440545
references.citation: Genet Med. 2007 Oct;9(10):665-74
references.pmid: 18073579
references.citation: New Genet Soc. 2010 Sep 1;29(3):261-290
references.pmid: 21076647