title: Highly enantioselective hydrogenation of 2,4-diaryl-1,5-benzodiazepines catalyzed by dendritic phosphinooxazoline iridium complexes.
abstract: A PHOX with arms: A series of dendrimers with Ir phosphinooxazoline (PHOX) cores were designed and synthesized and found to be highly effective and recoverable catalysts for asymmetric hydrogenation of 2,4-diaryl-1,5-benzodiazepines. An obvious positive dendritic effect on reactivity was observed, leading to chiral nitrogen-containing heterocycles with excellent enantioselectivities.
authors.affiliation: Beijing National Laboratory for Molecular Sciences and CAS, Institute of Chemistry and Graduate School, Chinese Academy of Sciences (CAS), Beijing 100190, PR China.
authors.forename: Baode
authors.initials: B
authors.lastname: Ma
authors.forename: Ziyuan
authors.initials: Z
authors.lastname: Ding
authors.forename: Ji
authors.initials: J
authors.lastname: Liu
authors.forename: Yanmei
authors.initials: Y
authors.lastname: He
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Fan
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D050091:Dendrimers / Q000737:chemistry*; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D050091:Dendrimers; D009942:Organometallic Compounds; D010080:Oxazoles; D010720:Phosphines; D001569:Benzodiazepines; D007495:Iridium