title: Role of the ubiquitin proteasome system in the heart.
abstract: Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired proteasomal function appears to contribute to heart disease. Specific proteasomal degradation mechanisms underlying cardiovascular biology and disease have been identified, and such cellular pathways have been proposed to be targets of clinical relevance. This review summarizes the latest literature regarding the specific E3 ligases involved in heart biology, and the general ways that the proteasome regulates protein quality control in heart disease. The potential for therapeutic intervention in Ubiquitin Proteasome System function in heart disease is discussed.
authors.affiliation: Department of Translational Medical Sciences, Via Sergio Pansini, 5, 80131 Naples, Italy.
authors.forename: Julia
authors.initials: J
authors.lastname: Pagan
authors.forename: Tiffany
authors.initials: T
authors.lastname: Seto
authors.forename: Michele
authors.initials: M
authors.lastname: Pagano
authors.forename: Antonio
authors.initials: A
authors.lastname: Cittadini
mesh_terms: D000818:Animals; D006333:Heart Failure / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D009206:Myocardium / Q000201:enzymology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex