title: Traceless Staudinger acetylation of azides in aqueous buffers.
abstract: In this paper, we demonstrate the applicability of water-soluble p-dimethylaminoethyl substituted phosphinomethanethiol in acetyl transfer reactions by the traceless Staudinger ligation with unprotected ε-azido lysine containing peptides in aqueous buffer systems. Additionally, we present an improved synthesis pathway for the water-soluble phosphinothiol linkers requiring less steps in a comparable overall yield in comparison to previously published protocols.
authors.affiliation: Maria Curie-Sklodowska University, Department of Organic Chemistry, ul. Gliniana 33, 20-614 Lublin, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Sowa
authors.forename: Michaela
authors.initials: M
authors.lastname: Mühlberg
authors.forename: K Michal
authors.initials: KM
authors.lastname: Pietrusiewicz
authors.forename: Christian P R
authors.initials: CP
authors.lastname: Hackenberger
mesh_terms: D000107:Acetylation; D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry; D002021:Buffers; D015394:Molecular Structure; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D001386:Azides; D002021:Buffers; D010720:Phosphines; D014867:Water; C044646:phosphine