title: Heat-shock proteins as dendritic cell-targeting vaccines--getting warmer.
abstract: Heat-shock proteins (hsp) provide a natural link between innate and adaptive immune responses by combining the ideal properties of antigen carriage (chaperoning), targeting and activation of antigen-presenting cells (APC), including dendritic cells (DC). Targeting is achieved through binding of hsp to distinct cell surface receptors and is followed by antigen internalization, processing and presentation. An improved understanding of the interaction of hsp with DC has driven the development of numerous hsp-containing vaccines, designed to deliver antigens directly to DC. Studies in mice have shown that for cancers, such vaccines generate impressive immune responses and protection from tumour challenge. However, translation to human use, as for many experimental immunotherapies, has been slow partly because of the need to perform trials in patients with advanced cancers, where demonstration of efficacy is challenging. Recently, the properties of hsp have been used for development of prophylactic vaccines against infectious diseases including tuberculosis and meningitis. These hsp-based vaccines, in the form of pathogen-derived hsp-antigen complexes, or recombinant hsp combined with selected antigens in vitro, offer an innovative approach against challenging diseases where broad antigen coverage is critical.
authors.affiliation: ImmunoBiology Ltd., Babraham Research Campus, Babraham, Cambridge, UK. shaun.mcnulty@immbio.com
authors.forename: Shaun
authors.initials: S
authors.lastname: McNulty
authors.forename: Camilo A
authors.initials: CA
authors.lastname: Colaco
authors.forename: Lucy E
authors.initials: LE
authors.lastname: Blandford
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Bailey
authors.forename: Selene
authors.initials: S
authors.lastname: Baschieri
authors.forename: Stephen
authors.initials: S
authors.lastname: Todryk
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology* / Q000378:metabolism; D019496:Cancer Vaccines / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D011956:Receptors, Cell Surface / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology* / Q000378:metabolism
chemical_list: D001428:Bacterial Vaccines; D019496:Cancer Vaccines; D006360:Heat-Shock Proteins; D011956:Receptors, Cell Surface; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
keywords: Cancer; dendritic cells; heat-shock proteins; infectious disease; vaccines
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