title: [Gastric cancer risk estimate in patients with chronic gastritis associated with Helicobacter pylori infection in a clinical setting].
abstract: OBJECTIVE
  Severity of chronic gastritis associated with Helicobacter pylori infection (CGAHpI) could play a role in evaluating the potential risk to develop gastric cancer. Our aim was to estimate the risk for gastric cancer in a clinical setting, according to histopathologic criteria, by applying the gastric cancer risk index (GCRI) METHODS: Histopathologic study of the gastric biopsies (corpus-antrum) from consecutive adult patients that underwent gastroesophageal duodenoscopy was carried out, and the GCRI was applied in patients presenting with CGAHpI.
  
  
  RESULTS
  One hundred eleven patients (77% female) with a mean age of 38.6±13.1 years were included. Active Helicobacter pylori infection (aHpi) was diagnosed in 77 cases (69.40%). In 45% of the cases with aHpi, pangastritis (23%) or corpus-predominant gastritis (22%) was diagnosed. Nine cases were diagnosed with intestinal metaplasia (8%), 7 of which (77.70%) were in the aHpi group. Twenty one percent of the patients with aHpi had a GCRI of 2 (18.10%) or 3 (2.50%) points (high risk index), while 79.10% accumulated a GCRI of 0 or 1 points (low risk index). Of the patients with no aHpi, none of them had 3 points (p=0.001). Of the 18 patients that accumulated 2 or 3 points, 6 (33.30%) presented with intestinal metaplasia (all with pangastritis and corpus-predominant gastritis), of which 4 cases (66.60%) had aHpi.
  
  
  CONCLUSIONS
  The estimated gastric cancer risk in patients with CGAHpI in the clinical setting studied was relatively low and 5% of the patients had a histopathologic phenotype associated with an elevated risk for developing gastric cancer.
authors.affiliation: Laboratorio de Investigaciones Gastrointestinales, Instituto de Investigaciones Biológicas, Maracaibo, Venezuela. Electronic address: gabrielarismendi@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Arismendi-Morillo
authors.forename: I
authors.initials: I
authors.lastname: Hernández
authors.forename: E
authors.initials: E
authors.lastname: Mengual
authors.forename: N
authors.initials: N
authors.lastname: Abreu
authors.forename: N
authors.initials: N
authors.lastname: Molero
authors.forename: A
authors.initials: A
authors.lastname: Fuenmayor
authors.forename: G
authors.initials: G
authors.lastname: Romero
authors.forename: M
authors.initials: M
authors.lastname: Lizarzábal
mesh_terms: D002908:Chronic Disease; D016099:Endoscopy, Gastrointestinal; D005756:Gastritis / Q000145:classification / Q000150:complications / Q000453:epidemiology*; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology* / Q000276:immunology; D016480:Helicobacter pylori / Q000254:growth & development; D006801:Humans; D008679:Metaplasia / Q000473:pathology; D018570:Risk Assessment; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology
keywords: Chronic gastritis; Cáncer gástrico; Gastric cancer; Gastritis crónica; Helicobacter pylori; Intestinal metaplasia; Metaplasia intestinal