title: [Characteristic of the complement system in patients with ischemic heart disease with moderate and marked hemolysis after operations with cardiopulmonary bypass].
abstract: A study of the complement system in cardiosurgical patients with moderate (40 patients) and marked (18 patients) hemolysis after coronary artery bypass grafting in conditions of cardiopulmonary bypass was carried out. Before and after operation the content of D35+-, D55+-erythrocytes and reticulocytes in blood, free hemoglobin in blood plasma, indicators of the functional state of classical, lectin and alternative pathways of complement activation as well as concentration of its terminal complex in blood serum were analyzed. It was established that development of marked hemolysis was associated with higher (compared with moderate hemolysis) content of terminal complement complex and reticulocytes in blood before operation as well as deficiency of D55+- erythrocytes and low activity of alternative pathway.
authors.forename: S P
authors.initials: SP
authors.lastname: Chumakova
authors.forename: O I
authors.initials: OI
authors.lastname: Urazova
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskiĭ
authors.forename: V M
authors.initials: VM
authors.lastname: Shipulin
authors.forename: O A
authors.initials: OA
authors.lastname: Khokhlov
authors.forename: T V
authors.initials: TV
authors.lastname: Emel'ianova
authors.forename: M A
authors.initials: MA
authors.lastname: Mikhaĭlova
mesh_terms: D018958:CD55 Antigens / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods; D015938:Complement Membrane Attack Complex / Q000032:analysis / Q000378:metabolism; D003170:Complement Pathway, Alternative; D001026:Coronary Artery Bypass / Q000379:methods; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006452:Hemoglobinometry; D006461:Hemolysis / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000601:surgery; D017463:Receptors, Complement 3b / Q000378:metabolism; D017701:Reticulocyte Count; D012720:Severity of Illness Index
chemical_list: D018958:CD55 Antigens; D015938:Complement Membrane Attack Complex; D017463:Receptors, Complement 3b