title: [The actual place of molecular analysis for donors and recipients in red blood cell immuno-hematology].
abstract: Molecular testing in red blood cell immuno-haematology is used extensively since the last 5 past years because of the technical developments and the possibility to use commercial kits. But these analyses have a high cost and rely on dedicated laboratories. Therefore, serology remains a reference technique for many laboratories in France, and in the world. Molecular analyses are used to resolve problems that cannot be resolved by serology. In this review, we will detail the main indications of molecular analysis, in donors and recipients, taking into account the technical tools that we can use, and the knowledge that we have about blood groups and their different variants. In this context, we have to remember that a molecular analysis has to be performed only if there is a benefice for the patient in the transfusion or the obstetrical setting.
authors.affiliation: Établissement français du sang Île-de-France, Inserm U955, université Paris-Est-Créteil, 51, avenue du Mal-de-Lattre-de-Tassigny, 94000 Créteil, France. france.noizat-pirenne@efs.sante.fr
authors.forename: F
authors.initials: F
authors.lastname: Noizat-Pirenne
mesh_terms: D001782:Blood Donors; D001789:Blood Group Antigens / Q000032:analysis / Q000235:genetics*; D001787:Blood Group Incompatibility / Q000517:prevention & control; D001788:Blood Grouping and Crossmatching / Q000379:methods*; D058731:Blood Safety; D001803:Blood Transfusion / Q000379:methods; D003298:Coombs Test; D005260:Female; D060005:Genotyping Techniques / Q000379:methods*; D006405:Hematology / Q000379:methods*; D006801:Humans; D007125:Immunogenetics / Q000379:methods*; D007202:Indicators and Reagents / Q000600:supply & distribution; D008297:Male; D025202:Molecular Diagnostic Techniques; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood; D012203:Rh Isoimmunization / Q000097:blood; D065227:Transfusion Reaction
chemical_list: D001789:Blood Group Antigens; D007202:Indicators and Reagents