title: [The effect of rocuronium and sugammadex in hepatic tumor patients without preoperative hepatic impairment].
abstract: BACKGROUND
  The effect of rocuronium and sugammadex in patients undergoing hepatectomy due to hepatic tumor without preoperative hepatic impairment were investigated.
  
  
  METHODS
  We studied 15 patients undergoing hepatectomy and 20 patients undergoing non-hepatic surgery No patients had preoperative hepatic impairment. Anesthesia was induced and maintained with propofol and remifentanil. Train-of-four (TOF) responses of the adductor pollicis to the supramaximal ulnar nerve stimulation were monitored by acceleromyography. A single dose of rocuronium 0.9 mg x kg(-1) was administered, and after spontaneous recovery of T1 to 25%, rocuronium was infused continuously to keep the posttetanic count 1-2. After surgery, sugammadex 4 mg x kg(-1) was administered.
  
  
  RESULTS
  In hepatectomy patients, duration from the administration of rocuronium to recovery of T1 to 25% was longer (88 +/- 20 vs 68 +/- 16 min, P < 0.01), and the total dose of rocuronium used during surgery was less (8.8 +/- 1.7 vs 11.4 +/- 2.7 microg x kg(-1) x min(-1), P < 0.01). However, there were no differences in the duration from administration of sugammadex to recovery of TOF ratio to 0.9 between two groups (138 +/- 55 vs 164 +/- 79 sec, P = 0.29).
  
  
  CONCLUSIONS
  Rocuronium-induced neuromuscular block was prolonged in hepatectomy patients even without preoperative hepatic impairment but the reversal with sugammadex was effective.
authors.affiliation: Department of Anesthesiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-0811.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nonaka
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nishi
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D000732:Androstanols / Q000494:pharmacology*; D000762:Anesthesia Recovery Period; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D000077123:Rocuronium; D000077122:Sugammadex; D013997:Time Factors; D047408:gamma-Cyclodextrins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium