title: Differential susceptibility to cadmium-induced liver and kidney injury in wild and laboratory-bred bank voles Myodes glareolus.
abstract: The objective of the study was to compare the sensitivity of wild and laboratory-bred bank voles to cadmium (Cd)-induced histopathological changes in the liver and kidneys. For 4 weeks, the male bank voles-both wild and laboratory-bred-were provided with diet containing Cd in quantities <0.1 (control), 30, and 60 μg/g dry weight. At the end of exposure period, histopathology and analyses of Cd, metallothionein (MT), glutathione (GSH), zinc (Zn), copper (Cu), iron (Fe), and lipid peroxidation-all considered to be critical factors during the development of Cd toxicity in the liver and kidneys-were carried out. Histopathological changes (focal hepatocyte swelling, vacuolation and inflammation [leukocyte infiltration] in the liver, and focal proximal tubule degeneration [including epithelial cell swelling] in the kidneys) occurred only in the wild bank voles fed a diet containing 60 μg Cd/g. There were no differences in concentrations of Cd, MT, GSH, Zn, and Cu in liver and kidney between the respective groups of wild and laboratory-bred animals. However, a decrease of hepatic Fe and lipid peroxidation was observed in the wild voles exhibiting histopathological changes. These data indicate the following: (1) wild bank voles are more susceptible to Cd-induced liver and kidney injury than those bred and raised in the laboratory; (2) the difference in sensitivity may be associated with a distinct decrease of hepatic Fe in response to Cd exposure between the two groups of bank voles; and (3) dietary Cd may produce histopathological changes indirectly through decreasing the hepatic Fe and Fe-dependent oxidative processes. These results also suggest that histopathology in the liver and kidney of wild bank voles living in a contaminated environment may occur at relatively low levels of tissue Cd.
authors.affiliation: Institute of Biology, University of Białystok, Świerkowa 20B, 15-950 Białystok, Poland.
authors.forename: Aneta
authors.initials: A
authors.lastname: Salińska
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Włostowski
authors.forename: Ewa
authors.initials: E
authors.lastname: Oleńska
mesh_terms: D000818:Animals; D000835:Animals, Wild; D003411:Arvicolinae; D002104:Cadmium / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000662:veterinary*; D004198:Disease Susceptibility; D007674:Kidney Diseases / Q000139:chemically induced / Q000662:veterinary*; D008297:Male
chemical_list: D002104:Cadmium
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