title: Assembled microcapsules by doxorubicin and polysaccharide as high effective anticancer drug carriers.
abstract: Doxorubicin, together with the modified polysaccharide (alginate dialdehyde), was used as a wall material to fabricate microcapsules through self-cross-linking by a template method. The microcapsules as-prepared are pH-responsive. Relevant scanning electronic microscopy, atom force microscopy and confocal laser scanning microscopy confirm the morphology of the uniform microcapsules. The spectroscopic results show that the microcapsules are assembled through electrostatic interaction and Schiff's base covalent bonding. Doxorubicin can be released sustainably from the capsules in buffer solution at a lower pH value. The cellular uptake of the microcapsules and drug release induced by acidic microenvironment are time-dependent processes. The cell cytotoxicity experiments in vitro demonstrate that the doxorubicin-based microcapsules have high efficiency to kill the cancer cells.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Fax: +86 10 82612629.
authors.forename: Cuiling
authors.initials: C
authors.lastname: Du
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Jinbo
authors.initials: J
authors.lastname: Fei
authors.forename: Yue
authors.initials: Y
authors.lastname: Cui
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000633:toxicity; D002214:Capsules / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells; D011134:Polysaccharides / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry; D055672:Static Electricity
chemical_list: D000903:Antibiotics, Antineoplastic; D002214:Capsules; D004337:Drug Carriers; D011134:Polysaccharides; D012545:Schiff Bases; D004317:Doxorubicin
keywords: anticancer drug; doxorubicin; drug delivery; microcapsule; molecular assembly