title: From gut changes to type 2 diabetes remission after gastric bypass surgeries.
abstract: Increasing evidence suggests that the gut may influence the host's metabolism and ultimately change the outcomes of type 2 diabetes mellitus (T2DM). We review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgery, and discuss the potential mechanisms underlying the above relationship: gut anatomical rearrangement, microbial composition changes, altered gut cells, and gut hormone modulation. However, the exact changes and their relative importance in the metabolic improvements after gastric bypass surgery remain to be further clarified. Elucidating the precise metabolic mechanisms of T2DM resolution after bypass surgery will help to reveal the molecular mechanisms of pathogenesis, and facilitate the development of novel diagnoses and preventative interventions for this common disease.
authors.affiliation: Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, CAS, Shanghai, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Xinrong
authors.initials: X
authors.lastname: Zhou
authors.forename: Jiarui
authors.initials: J
authors.lastname: Wu
authors.forename: Huarong
authors.initials: H
authors.lastname: Zhou
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000601:surgery; D015390:Gastric Bypass / Q000379:methods*; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D007328:Insulin / Q000378:metabolism; D009765:Obesity / Q000378:metabolism / Q000601:surgery*; D012074:Remission Induction
chemical_list: D007328:Insulin
references.citation: Int J Obes (Lond). 2009 Jul;33(7):758-67
references.pmid: 19050675
references.citation: Obes Surg. 2002 Jun;12(3):324-7
references.pmid: 12082881
references.citation: Obesity (Silver Spring). 2009 Sep;17(9):1671-7
references.pmid: 19360006
references.citation: Cell Host Microbe. 2012 Feb 16;11(2):140-52
references.pmid: 22341463
references.citation: Endocrinology. 2008 Nov;149(11):5670-8
references.pmid: 18669601
references.citation: Lancet. 2012 Jun 16;379(9833):2300-11
references.pmid: 22683132
references.citation: Diabetes Care. 2004 May;27(5):1047-53
references.pmid: 15111519
references.citation: Proc Natl Acad Sci U S A. 1982 Jul;79(14):4471-5
references.pmid: 6956876
references.citation: Science. 2010 Apr 9;328(5975):228-31
references.pmid: 20203013
references.citation: Ann Surg. 2000 Oct;232(4):515-29
references.pmid: 10998650
references.citation: Ann Surg. 2006 Jan;243(1):108-14
references.pmid: 16371744
references.citation: Nature. 2012 Jun 13;486(7402):207-14
references.pmid: 22699609
references.citation: J Clin Endocrinol Metab. 2006 May;91(5):1735-40
references.pmid: 16478824
references.citation: Neuropeptides. 2006 Oct;40(5):317-24
references.pmid: 17045646
references.citation: J Clin Endocrinol Metab. 2006 Jul;91(7):2574-81
references.pmid: 16621911
references.citation: Obes Surg. 2011 Jun;21(6):759-62
references.pmid: 21547404
references.citation: J Clin Invest. 1967 Dec;46(12):1954-62
references.pmid: 6074000
references.citation: Physiol Behav. 2011 Nov 30;105(1):106-19
references.pmid: 21315095
references.citation: Arch Surg. 2004 Jul;139(7):780-4
references.pmid: 15249413
references.citation: Diabetes. 2010 Dec;59(12):3049-57
references.pmid: 20876719
references.citation: Nature. 1999 Dec 9;402(6762):656-60
references.pmid: 10604470
references.citation: Nat Genet. 2012 Mar 11;44(4):406-12, S1
references.pmid: 22406641
references.citation: Cell Metab. 2008 Sep;8(3):201-11
references.pmid: 18762021
references.citation: Curr Opin Genet Dev. 1999 Jun;9(3):295-300
references.pmid: 10377278
references.citation: Gastroenterology. 1985 Nov;89(5):1070-7
references.pmid: 3840109
references.citation: Nature. 2006 Dec 14;444(7121):854-9
references.pmid: 17167473
references.citation: Diabetes Care. 2012 Jul;35(7):1420-8
references.pmid: 22723580
references.citation: Nat Rev Endocrinol. 2010 Feb;6(2):102-9
references.pmid: 20098450
references.citation: Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E142-7
references.pmid: 17971509
references.citation: J Mol Med (Berl). 1997 May;75(5):327-40
references.pmid: 9181474
references.citation: Surg Endosc. 2008 Apr;22(4):1029-34
references.pmid: 18270777
references.citation: Neurosci Lett. 2008 Mar 5;433(1):38-42
references.pmid: 18248897
references.citation: J Clin Endocrinol Metab. 2002 Jun;87(6):2988
references.pmid: 12050285
references.citation: J Clin Invest. 2004 Feb;113(4):635-45
references.pmid: 14966573
references.citation: Endocrinology. 1996 Jul;137(7):2968-78
references.pmid: 8770921
references.citation: Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E122-31
references.pmid: 22535748
references.citation: J Clin Endocrinol Metab. 2003 Sep;88(9):4227-31
references.pmid: 12970291
references.citation: Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23
references.pmid: 15505215
references.citation: N Engl J Med. 1996 Mar 21;334(12):777-83
references.pmid: 8592553
references.citation: Mol Cell Biol. 2009 Aug;29(16):4417-30
references.pmid: 19506018
references.citation: Trends Endocrinol Metab. 1999 Aug;10(6):229-235
references.pmid: 10407397
references.citation: Diabetes. 1998 Dec;47(12):1817-23
references.pmid: 9836511
references.citation: Obesity (Silver Spring). 2009 Oct;17(10):1906-15
references.pmid: 19390523
references.citation: Ann Surg. 2007 Nov;246(5):780-5
references.pmid: 17968169
references.citation: Endocrinology. 1987 Aug;121(2):704-13
references.pmid: 3595539
references.citation: Surg Obes Relat Dis. 2007 Nov-Dec;3(6):597-601
references.pmid: 17936091
references.citation: Diabetes Care. 2010 Feb;33(2):375-7
references.pmid: 19918005
references.citation: Am J Physiol Regul Integr Comp Physiol. 2001 May;280(5):R1483-7
references.pmid: 11294772
references.citation: Nature. 2006 Dec 21;444(7122):1022-3
references.pmid: 17183309
references.citation: Lancet. 2012 Jun 16;379(9833):2243-51
references.pmid: 22683134
references.citation: J Clin Endocrinol Metab. 2008 Jul;93(7):2479-85
references.pmid: 18430778
references.citation: Biochem Soc Trans. 2006 Nov;34(Pt 5):722-6
references.pmid: 17052182
references.citation: Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E447-53
references.pmid: 15454396
references.citation: Curr Microbiol. 2010 Jul;61(1):69-78
references.pmid: 20087741
references.citation: Development. 2002 May;129(10):2447-57
references.pmid: 11973276
references.citation: Science. 1976 Jan 16;191(4223):191-2
references.pmid: 1108195
references.citation: J Clin Endocrinol Metab. 2002 Mar;87(3):1300-8
references.pmid: 11889202
references.citation: Science. 2001 Nov 30;294(5548):1866-70
references.pmid: 11729302
references.citation: Diabetes Care. 2007 Jul;30(7):1709-16
references.pmid: 17416796
references.citation: Gastroenterology. 1992 May;102(5):1654-9
references.pmid: 1568575
references.citation: Obes Res. 2004 Jul;12(7):1108-16
references.pmid: 15292475
references.citation: Am J Physiol. 1997 Oct;273(4):G920-7
references.pmid: 9357836
references.citation: Pharmacol Ther. 2012 Sep;135(3):316-26
references.pmid: 22749794
references.citation: Genes Dev. 2002 Jun 15;16(12):1488-97
references.pmid: 12080087
references.citation: Gut. 1971 Apr;12(4):311-8
references.pmid: 4930155
references.citation: Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2365-70
references.pmid: 19164560
references.citation: Br J Surg. 2006 Feb;93(2):210-5
references.pmid: 16392104
references.citation: Diabetologia. 2010 Apr;53(4):699-711
references.pmid: 20033803
references.citation: Gastroenterology. 2007 May;132(6):2253-71
references.pmid: 17498516
references.citation: Cell. 2008 Jan 25;132(2):197-207
references.pmid: 18243096
references.citation: Lancet. 1987 Dec 5;2(8571):1300-4
references.pmid: 2890903
references.citation: Int J Obes (Lond). 2010 Mar;34(3):462-71
references.pmid: 20029383
references.citation: Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1607-11
references.pmid: 10677506
references.citation: J Clin Endocrinol Metab. 2005 Jan;90(1):359-65
references.pmid: 15483088
references.citation: Annu Rev Med. 2011;62:361-80
references.pmid: 21226616
references.citation: Gastroenterology. 2007 May;132(6):2116-30
references.pmid: 17498507
references.citation: J Clin Endocrinol Metab. 2005 Dec;90(12):6386-91
references.pmid: 16204364
references.citation: Obesity (Silver Spring). 2006 Sep;14(9):1553-61
references.pmid: 17030966
references.citation: J Clin Endocrinol Metab. 2011 Jul;96(7):2227-35
references.pmid: 21543426
references.citation: Nature. 2009 Jan 22;457(7228):480-4
references.pmid: 19043404
references.citation: Regul Pept. 1984 Jul;8(4):261-6
references.pmid: 6548568
references.citation: Ann Surg. 1995 Sep;222(3):339-50; discussion 350-2
references.pmid: 7677463
references.citation: Nature. 2012 Oct 4;490(7418):55-60
references.pmid: 23023125
references.citation: Endocrinology. 2000 Nov;141(11):4255-61
references.pmid: 11089560
references.citation: J Surg Res. 2012 Nov;178(1):33-9
references.pmid: 22929182
references.citation: Cell Metab. 2009 Sep;10(3):167-77
references.pmid: 19723493
references.citation: Diabetes. 2005 Aug;54(8):2390-5
references.pmid: 16046306
references.citation: Obes Surg. 1999 Jun;9(3):223-8
references.pmid: 10484306
references.citation: J Clin Endocrinol Metab. 2004 Jun;89(6):2608-15
references.pmid: 15181031
references.citation: Dev Biol. 2004 Jun 15;270(2):443-54
references.pmid: 15183725
references.citation: Obes Surg. 2009 Mar;19(3):313-20
references.pmid: 18815849
references.citation: Obes Res. 2001 Nov;9 Suppl 4:228S-233S
references.pmid: 11707546
references.citation: Science. 2005 Mar 25;307(5717):1909-14
references.pmid: 15790843
references.citation: J Clin Endocrinol Metab. 2010 Aug;95(8):4072-6
references.pmid: 20501690
references.citation: J Clin Endocrinol Metab. 2007 Dec;92(12):4678-85
references.pmid: 17895322
references.citation: Nature. 2002 Aug 8;418(6898):650-4
references.pmid: 12167864
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16767-72
references.pmid: 18931303
references.citation: Endocrinology. 2012 Aug;153(8):3613-9
references.pmid: 22673227
references.citation: World J Surg. 1998 Sep;22(9):936-46
references.pmid: 9717419
references.citation: N Engl J Med. 2012 Aug 23;367(8):695-704
references.pmid: 22913680
references.citation: Curr Opin Clin Nutr Metab Care. 2005 Jul;8(4):445-9
references.pmid: 15930972
references.citation: Nat Med. 2010 Apr;16(4):392-5
references.pmid: 20376051
references.citation: J Embryol Exp Morphol. 1977 Oct;41:209-22
references.pmid: 22577
references.citation: Diabetes Metab Rev. 1992 Dec;8(4):287-338
references.pmid: 1307522
references.citation: J Clin Endocrinol Metab. 2000 Dec;85(12):4908-11
references.pmid: 11134161
references.citation: Obesity (Silver Spring). 2008 Feb;16(2):298-305
references.pmid: 18239636
references.citation: J Gastrointest Surg. 2011 Jun;15(6):928-34
references.pmid: 21431992
references.citation: J Clin Endocrinol Metab. 2003 Oct;88(10):4696-701
references.pmid: 14557443
references.citation: J Clin Endocrinol Metab. 2001 Oct;86(10):5083-6
references.pmid: 11600590
references.citation: Obes Res. 2003 Aug;11(8):919-24
references.pmid: 12917494
references.citation: Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G795-802
references.pmid: 21372167
references.citation: Int J Obes (Lond). 2008 Nov;32(11):1720-4
references.pmid: 18779823
references.citation: Obes Surg. 2011 Jul;21(7):841-9
references.pmid: 20379796
references.citation: Cell. 2007 Apr 20;129(2):251-62
references.pmid: 17448988
references.citation: Gastroenterology. 2007 May;132(6):2131-57
references.pmid: 17498508
references.citation: Annu Rev Physiol. 1997;59:257-71
references.pmid: 9074764
references.citation: Endocrinology. 2004 Jun;145(6):2639-44
references.pmid: 15044355
references.citation: Dev Biol. 2010 Mar 1;339(1):26-37
references.pmid: 20025861
references.citation: Diabetes Care. 2009 Dec;32(12):2225-9
references.pmid: 19940225
references.citation: Nat Med. 2012 Jun;18(6):950-5
references.pmid: 22610279
references.citation: Nat Genet. 2000 Jan;24(1):36-44
references.pmid: 10615124
references.citation: Surg Obes Relat Dis. 2007 Mar-Apr;3(2):195-7
references.pmid: 17386401
references.citation: Biochem Biophys Res Commun. 2000 Dec 29;279(3):909-13
references.pmid: 11162448
references.citation: Appl Environ Microbiol. 2007 Feb;73(4):1073-8
references.pmid: 17189447
references.citation: Biochem Biophys Res Commun. 2005 Apr 1;329(1):386-90
references.pmid: 15721318
references.citation: Int J Obes (Lond). 2008 Jun;32(6):943-8
references.pmid: 18317469
references.citation: JAMA. 2002 Dec 11;288(22):2793-6
references.pmid: 12472304
references.citation: Int J Obes (Lond). 2008 Nov;32(11):1640-6
references.pmid: 18794895
references.citation: Endocrinology. 2001 Oct;142(10):4244-50
references.pmid: 11564680
references.citation: Surg Obes Relat Dis. 2010 Mar 4;6(2):126-31
references.pmid: 20359665
references.citation: PLoS One. 2010 Feb 05;5(2):e9085
references.pmid: 20140211
references.citation: Biochem Pharmacol. 2010 Dec 1;80(11):1727-35
references.pmid: 20735990
references.citation: Science. 2005 Jun 10;308(5728):1635-8
references.pmid: 15831718
references.citation: Int J Obes Relat Metab Disord. 2004 Aug;28(8):963-71
references.pmid: 15197409
references.citation: J Clin Endocrinol Metab. 1983 Sep;57(3):488-95
references.pmid: 6874888
references.citation: Development. 2000 Aug;127(16):3533-42
references.pmid: 10903178
references.citation: Am J Surg. 2002 Dec;184(6B):9S-16S
references.pmid: 12527344