title: Comparison of standard and low dose intraoperative mitomycin C in prevention of corneal hazeafter photorefractive keratectomy.
abstract: BACKGROUND
  This study aimed to compare two doses of Mitomycin C in reducing haze formation after photorefractive keratectomy.
  
  
  METHODS
  170 eyes of 85 patients enrolled; in each patient one eye randomly assigned to be treated by low dose intraoperative MMC (LDMMC) and other eye by standard dose MMC (SDMMC). Then the patients were followed up to 6 months and refraction, Uncorrected Distant Visual Acuity (UCDVA), Best Corrected Distant Visual Acuity (BCDVA) and haze formation submitted in each postoperative exam.
  
  
  RESULTS
  The mean preoperative refraction in LDMMC eyes was -3.08 (SD 1.65) sphere and 0.92 (SD 0.88) cylinder. These values for SDMMC eyes were -3.25 (SD 1.80) sphere and 0.81 (SD 0.84) cylinder. Mean postoperative sphere in LDMMC group was -0.132 (SD 0.503) and -0.138 (SD 0.484) in 3 and 6 months after PRK. These results was -0.041 (SD 0.501) and -0.076 (SD 0.489) for SDMMC group. Mean postoperative cylinder 3 and 6 month after PRK was 0.435 (SD 0.218) and 0.423 (SD 0.255). In LDMMC group and 0.435 (SD 0.247) and 0.426 (SD 0.261) in SDMMC group. In third month 14 eyes in LDMMC group presented with grade 1 score of clinical haze. From these eyes only 2 still had this haze after 6 month. 7 eyes in SDMMC group had grade 1 clinical haze at third month- but no clinical haze was seen at the end of 6(th) month.
  
  
  CONCLUSIONS
  The results of the two doses of Mitomycin C were not significant. We suggest to use the lower dose to reduce its side effects.
authors.affiliation: Department of Ophthalmology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Razmjoo
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Kooshanmehr
authors.forename: Alireza
authors.initials: A
authors.lastname: Peyman
authors.forename: Zahra
authors.initials: Z
authors.lastname: Kor
authors.forename: Erfan
authors.initials: E
authors.lastname: Mohammadesmaeil
keywords: Mitomycin C; Photorefractive keratectomy; corneal haze
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