title: Multicenter, double-blind, parallel group study investigating the non-inferiority of efficacy and safety of a 2% miconazole nitrate shampoo in comparison with a 2% ketoconazole shampoo in the treatment of seborrhoeic dermatitis of the scalp.
abstract: OBJECTIVE
  This study investigated the non-inferiority of efficacy and tolerance of 2% miconazole nitrate shampoo in comparison with 2% ketoconazole shampoo in the treatment of scalp seborrheic dermatitis.
  
  
  METHODS
  A randomized, double-blind, comparative, parallel group, multicenter study was done. A total of 274 patients (145 miconazole, 129 ketoconazole) were enrolled. Treatment was twice-weekly for 4 weeks. Safety and efficacy assessments were made at baseline and at weeks 2 and 4. Assessments included symptoms of erythema, itching, scaling ['Symptom Scale of Seborrhoeic Dermatitis' (SSSD)], disease severity and global change [Clinical Global Impressions (CGIs) and Patient Global Impressions (PGIs)].
  
  
  CONCLUSIONS
  Miconazole shampoo is at least as effective and safe as ketoconazole shampoo in treating scalp seborrheic dermatitis scalp.
authors.affiliation: Private Dermatology office, Blumenrain 20, CH 4051 Basel , Switzerland.
authors.forename: Stanislaw A
authors.initials: SA
authors.lastname: Buechner
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D063807:Dandruff / Q000188:drug therapy; D012628:Dermatitis, Seborrheic / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006203:Hair Preparations / Q000008:administration & dosage*; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage*; D008297:Male; D008825:Miconazole / Q000008:administration & dosage*; D008875:Middle Aged; D012536:Scalp Dermatoses / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D006203:Hair Preparations; D008825:Miconazole; D007654:Ketoconazole