title: [Hyperuricemia and acute kidney injury following kidney transplantation : a case report].
abstract: We report a case of hyperuricemia and acute kidney injury associated with mizoribine (MZR). A 15- year-old male with congenital renal hypoplasia underwent kidney transplantation. We used tacrolimus extended release (0.15 mg/kg/day), mizoribine (MZR) (12 mg/kg/day), prednisolone and basiliximab as immunosuppressants. On the 35th post operative day, he complained of acute right chest pain, right inguinal pain and dyspnea. Serum uric acid and creatinine were elevated. Accordingly, we changed MZR to mycophenolate mofetil, and added allopurinol and potassium citrate. Gradually, the symptoms disappeared and renal function was improved. In this case, prolonged MZR metabolism, hyperuricemia and progressive renal dysfunction may have formed a vicious cycle. In conclusion, monitoring of serum uric acid level is necessary, especially when using a high dose MZR.
authors.affiliation: The Department of Urology, Osaka General Medical Center, Japan.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Nakazawa
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Imamura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Takuji
authors.initials: T
authors.lastname: Hayashi
authors.forename: Go
authors.initials: G
authors.lastname: Tanigawa
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Fujita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hosomi
authors.forename: Seiji
authors.initials: S
authors.lastname: Yamaguchi
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000293:Adolescent; D006801:Humans; D033461:Hyperuricemia / Q000209:etiology*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced; D012263:Ribonucleosides / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine