title: A limited sampling strategy for tacrolimus in liver transplant patients.
abstract: To develop limited sampling strategy (LSS) equations to estimate area under the curve (AUC0-12) in Chinese adult transplant patients. 26 adult liver transplant patients were included in this study. The blood samples, collected within 12 hours, were analyzed by microparticle enzyme immunoassay. By multiple stepwise linear regression analysis, LSS equations were identified. The predictive performance of these models was validated by the jackknife technique. As a result, the two sampling time point (trough and 4 hours postdose) model accurately predicted AUC0-12. (R2 = 0.949, ICC = 0.976). The two-point LSS equation (AUC0-12 = 7.26 + (2.17·C0) + (8.30·C4)) can be used as a predictable measure of AUC0-12 of tacrolimus in Chinese liver transplant patients.
authors.affiliation: Department of Pharmacy, Tianjin First Center Hospital, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Zhu
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Rao
authors.forename: Wei
authors.initials: W
authors.lastname: Qu
authors.forename: Liying
authors.initials: L
authors.lastname: Sun
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001800:Blood Specimen Collection / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics*; D016014:Linear Models; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016559:Tacrolimus / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus