title: Induction of TRIF- or MYD88-dependent pathways perturbs cell cycle regulation in pancreatic cancer.
authors.forename: Constantinos P
authors.initials: CP
authors.lastname: Zambirinis
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ochi
authors.forename: Rocky
authors.initials: R
authors.lastname: Barilla
authors.forename: Stephanie
authors.initials: S
authors.lastname: Greco
authors.forename: Michael
authors.initials: M
authors.lastname: Deutsch
authors.forename: George
authors.initials: G
authors.lastname: Miller
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism*; D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism / Q000503:physiopathology*; D002453:Cell Cycle / Q000502:physiology*; D019938:Cyclin D1 / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*; D017154:Stromal Cells / Q000378:metabolism; D051197:Toll-Like Receptor 4 / Q000378:metabolism; D051199:Toll-Like Receptor 7 / Q000378:metabolism
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D019938:Cyclin D1; D008562:Membrane Glycoproteins; D053594:Myeloid Differentiation Factor 88; D051197:Toll-Like Receptor 4; D051199:Toll-Like Receptor 7; C507780:Myd88 protein, mouse; C476286:Ticam1 protein, mouse; C493487:Tlr4 protein, mouse; C477038:Tlr7 protein, mouse
keywords: p16; p21; p27; p53; pancreatic cancer
references.citation: J Exp Med. 2012 Aug 27;209(9):1671-87
references.pmid: 22908323
references.citation: Cell. 2010 Mar 19;140(6):805-20
references.pmid: 20303872
references.citation: Nat Rev Cancer. 2009 Jan;9(1):57-63
references.pmid: 19052556
references.citation: Oncogene. 2012 Mar 22;31(12):1599-608
references.pmid: 21860420
references.citation: Semin Cancer Biol. 2011 Dec;21(6):367-76
references.pmid: 22037160
references.citation: Nat Rev Cancer. 2009 Nov;9(11):798-809
references.pmid: 19851315
references.citation: J Clin Invest. 2012 Nov;122(11):4118-29
references.pmid: 23023703