title: Experimental evaluation of analgesic and anti-inflammatory potential of Oyster mushroom Pleurotus florida.
abstract: BACKGROUND
  Edible mushrooms have been used as flavorful foods and as health nutritional supplements for several centuries. A number of bioactive molecules have been identified in numerous mushroom species.
  
  
  OBJECTIVE
  To evaluate the analgesic and anti-inflammatory potential of Oyster Mushroom Pleurotus florida using various experimental models in Wistar rats.
  
  
  METHODS
  Acute toxicity studies were performed whereby dose of 250 mg/ kg and 500 mg/kg was selected for present study, Analgesic activity was determined using hot plate method, tail flick method, acetic acid induced writhing and formalin induced pain in rats, while carrageenan was used to induce inflammation and anti-inflammatory studies were performed.
  
  
  RESULTS
  HEE showed significant (P < 0.01) analgesic and anti-inflammatory response against all experimental models.
  
  
  CONCLUSIONS
  These studies conclude that Pleurotus florida possesses analgesic and anti- inflammatory potential which might be due to presence of myochemicals like flavonoids, phenolics and polysaccharides.
authors.affiliation: Department of Pharmacy, Shri Ram Institute of Technology, Jabalpur, Madhya Pradesh, India.
authors.forename: Aditya
authors.initials: A
authors.lastname: Ganeshpurkar
authors.forename: Gopal
authors.initials: G
authors.lastname: Rai
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006358:Hot Temperature; D007249:Inflammation / Q000188:drug therapy; D023421:Models, Animal; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D020076:Pleurotus; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts
keywords: Analgesic; Pleurotus florida; anti-inflammatory
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