title: The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.
authors.affiliation: College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.
authors.forename: Zhilin
authors.initials: Z
authors.lastname: Ren
authors.forename: Liming
authors.initials: L
authors.lastname: Yan
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Guo
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Lou
authors.forename: Zihe
authors.initials: Z
authors.lastname: Rao
mesh_terms: D001665:Binding Sites; D000086782:Coronavirus 3C Proteases; D003546:Cysteine Endopeptidases / Q000378:metabolism; D006801:Humans; D007555:Isoxazoles / Q000737:chemistry / Q000494:pharmacology; D010649:Phenylalanine / Q000031:analogs & derivatives; D011480:Protease Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology; D012229:Rhinovirus / Q000187:drug effects; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects / Q000201:enzymology*; D045169:Severe Acute Respiratory Syndrome / Q000821:virology*; D014633:Valine / Q000031:analogs & derivatives; D014764:Viral Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D007555:Isoxazoles; D011480:Protease Inhibitors; D011760:Pyrrolidinones; D014764:Viral Proteins; D010649:Phenylalanine; D003546:Cysteine Endopeptidases; D000086782:Coronavirus 3C Proteases; D014633:Valine; C118874:rupintrivir
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