title: The epidemiology of anaphylaxis in Europe: protocol for a systematic review.
abstract: BACKGROUND
  The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management and impact on quality of life, which will be used to inform clinical recommendations.The aims of this systematic review will be to understand and describe the epidemiology of anaphylaxis, i.e. frequency, risk factors and outcomes of anaphylaxis, and describe how these characteristics vary by person, place and time.
  
  
  METHODS
  A highly sensitive search strategy has been designed to retrieve all articles combining the concepts of anaphylaxis and epidemiology from electronic bibliographic databases.
  
  
  CONCLUSIONS
  This review will aim to provide some estimates of the incidence and prevalence of anaphylaxis in Europe. The occurrence of anaphylaxis can have a profound effect on the quality of life of the sufferer and their family. Estimates of disease frequency will help us to ascertain the burden of anaphylaxis and provide useful comparators for management strategies.
authors.affiliation: Centre for Population Health Sciences, The University of Edinburgh Medical School, Doorway 3, Teviot Place, Edinburgh, EH8 9AG, UK. aziz.sheikh@ed.ac.uk.
authors.forename: Sukhmeet S
authors.initials: SS
authors.lastname: Panesar
authors.forename: Bright I
authors.initials: BI
authors.lastname: Nwaru
authors.forename: Lennart
authors.initials: L
authors.lastname: Hickstein
authors.forename: Tamara
authors.initials: T
authors.lastname: Rader
authors.forename: Hala
authors.initials: H
authors.lastname: Hamadah
authors.forename: Dana Fawzi Ibrahim
authors.initials: DF
authors.lastname: Ali
authors.forename: Bhavesh
authors.initials: B
authors.lastname: Patel
authors.forename: Antonella
authors.initials: A
authors.lastname: Muraro
authors.forename: Graham
authors.initials: G
authors.lastname: Roberts
authors.forename: Margitta
authors.initials: M
authors.lastname: Worm
authors.forename: Aziz
authors.initials: A
authors.lastname: Sheikh
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