title: Effect of hyperglycemia on conduction parameters of tibial nerve's fibers to different muscles: A rat model.
abstract: BACKGROUND
  Routine conduction studies reflect the summation of all nerve fibers in a peripheral nerve. Nerve fiber groups to distal, small muscles have smaller diameters than the ones to large proximal muscles. There may be minimal differences between the diameters of nerve fiber groups innervating different muscles; even they are all same type of fibers. So, in neuropathic processes some nerve fiber groups may be more seriously affected.
  
  
  METHODS
  14 rats ( 7 diabetic, 7 control) were studied. Tibial nerve was stimulated from two points and while recorded from a distal (foot intrinsic muscles) and a proximal (gastrocnemius) muscle.
  
  
  RESULTS
  There was a significant difference between the proximal and distal recorded conduction velocities. Both proximal and distal recorded conduction velocities decreased during the hyperglycemic process.
  
  
  CONCLUSIONS
  Our method successfully demonstrated different nerve fiber groups; but, the neuropathic process seemed to be homogeneous in both fiber groups.
authors.affiliation: Department of Neurology, Pamukkale University, Denizli, Turkey.
authors.forename: Cağdaş
authors.initials: C
authors.lastname: Erdoğan
authors.forename: Utku
authors.initials: U
authors.lastname: Cenikli
authors.forename: Eylem
authors.initials: E
authors.lastname: Değirmenci
authors.forename: Attila
authors.initials: A
authors.lastname: Oğuzhanoğlu
keywords: Different nerve fiber groups in the same nerve; hyperglycemia; rat
references.citation: Muscle Nerve. 1995 Feb;18(2):175-84
references.pmid: 7823975
references.citation: J Neurosci Methods. 2006 Mar 15;151(2):131-8
references.pmid: 16125783
references.citation: Neurosci Lett. 1978 Apr;8(1):17-20
references.pmid: 19605142
references.citation: Eur J Neurol. 2009 Mar;16(3):375-9
references.pmid: 19364365
references.citation: Proc R Soc Lond B Biol Sci. 1981 Oct 14;213(1191):201-16
references.pmid: 6120515
references.citation: J Neurol Neurosurg Psychiatry. 1964 Aug;27:351-7
references.pmid: 14200791
references.citation: J Neurophysiol. 1965 May;28:581-98
references.pmid: 14328455
references.citation: Int J Neurosci. 2010 Jan;120(1):76-9
references.pmid: 20128676
references.citation: Diabetes Res Clin Pract. 2008 Jan;79(1):e17-8
references.pmid: 17764777
references.citation: Neurochem Res. 2007 Jun;32(6):1002-10
references.pmid: 17404843
references.citation: Physiol Rev. 1980 Jan;60(1):90-142
references.pmid: 6766557
references.citation: Muscle Nerve. 2011 Feb;43(2):237-44
references.pmid: 21254089