title: Abdominal adiposity through adipocyte secretion products, a risk factor for endometrial cancer.
abstract: OBJECTIVE
  The adipose cell has been considered an inert cell from a secretory point of view. Studies over the past years have confirmed the capacity of the adipocyte to synthesize many substances including: adiponectin, leptin, which integrate multiple metabolic and endocrine signals. In the context of endometrial cancer, abdominal obesity as a risk factor is associated with a chronic inflammatory process, confirmed by the increase of inflammatory markers. The study aimed to identify a correlation between abdominal obesity, plasma adipokine levels and endometrial cancer.
  
  
  METHODS
  Two groups of patients were included in the study: group I - 44 patients diagnosed with endometrial cancer, group II - 44 patients without gynecological pathology or inflammatory disorders. After the performance of clinical examination and anthropometric measurements, abdominal fat was determined by dual X-ray absorptiometry and plasma adiponectin and leptin levels were measured.
  
  
  RESULTS
  A significantly higher abdominal fat and leptin value was found in the group of patients in with endometrial cancer (p < 0.0001), while the plasma adiponectin level was significantly lower, compared to the control group (p < 0.0001). Abdominal fat was in a negative linear correlation with the plasma adiponectin level and in a positive linear correlation with the plasma leptin level.
  
  
  CONCLUSIONS
  The measurement of adiponectin and leptin levels associated with the determination of abdominal adipose tissue can be a useful predictor factor for endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Dan
authors.initials: D
authors.lastname: Mihu
authors.forename: Razvan
authors.initials: R
authors.lastname: Ciortea
authors.forename: Carmen Mihaela
authors.initials: CM
authors.lastname: Mihu
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism; D017667:Adipocytes / Q000378:metabolism; D052242:Adiponectin / Q000097:blood* / Q000378:metabolism; D050154:Adiposity; D000368:Aged; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: D052242:Adiponectin; D020738:Leptin