title: Novel pebbles in the mosaic of autoimmunity.
abstract: Almost 25 years ago, the concept of the 'mosaic of autoimmunity' was introduced to the scientific community, and since then this concept has continuously evolved, with new pebbles being added regularly. We are now looking at an era in which the players of autoimmunity have changed names and roles. In this issue of BMC Medicine, several aspects of autoimmunity have been addressed, suggesting that we are now at the forefront of autoimmunity science. Within the environmental factors generating autoimmunity are now included unsuspected molecules such as vitamin D and aluminum. Some adjuvants such as aluminum are recognized as causal factors in the development of the autoimmune response. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), has been recently described. This is the new wind blowing within the branches of autoimmunity, adding knowledge to physicians for helping patients with autoimmune disease.
authors.forename: Carlo
authors.initials: C
authors.lastname: Perricone
authors.forename: Nancy
authors.initials: N
authors.lastname: Agmon-Levin
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects; D000486:Allergy and Immunology / Q000639:trends; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000503:physiopathology*; D015551:Autoimmunity; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology
chemical_list: D000276:Adjuvants, Immunologic; D001323:Autoantibodies
references.citation: BMC Med. 2013 Apr 04;11:93
references.pmid: 23556533
references.citation: BMC Med. 2013 Apr 04;11:88
references.pmid: 23557513
references.citation: Immunol Today. 1989 Apr;10(4):123-6
references.pmid: 2665774
references.citation: Autoimmune Dis. 2012;2012:297193
references.pmid: 22666553
references.citation: Clin Rev Allergy Immunol. 2005 Dec;29(3):213-7
references.pmid: 16391396
references.citation: BMC Med. 2013 Apr 04;11:89
references.pmid: 23556408
references.citation: Clin Rev Allergy Immunol. 2013 Oct;45(2):256-66
references.pmid: 23238772
references.citation: Autoimmun Rev. 2012 Dec;12(2):174-94
references.pmid: 22982174
references.citation: Autoimmun Rev. 2011 Aug;10(10):599-608
references.pmid: 21545847
references.citation: PLoS One. 2012;7(3):e33824
references.pmid: 22461897
references.citation: Autoimmun Rev. 2011 Aug;10(10):575-6
references.pmid: 21621001
references.citation: Autoimmunity. 2004 May;37(3):183-8
references.pmid: 15497450
references.citation: Autoimmun Rev. 2011 Mar;10(5):244-7
references.pmid: 20863912
references.citation: BMC Med. 2013 Apr 04;11:92
references.pmid: 23566870
references.citation: Autoimmun Rev. 2013 Mar;12(5):599-606
references.pmid: 23183378
references.citation: Best Pract Res Clin Rheumatol. 2012 Feb;26(1):105-17
references.pmid: 22424197
references.citation: BMC Med. 2013 Apr 04;11:91
references.pmid: 23556481
references.citation: Curr Pharm Des. 2012;18(16):2305-13
references.pmid: 22390693
references.citation: Clin Rev Allergy Immunol. 2013 Aug;45(1):87-96
references.pmid: 23233263
references.citation: BMC Med. 2013 Apr 04;11:94
references.pmid: 23556986
references.citation: BMC Med. 2013 Apr 04;11:95
references.pmid: 23557013
references.citation: Clin Rev Allergy Immunol. 2010 Apr;38(2-3):169-77
references.pmid: 19543859
references.citation: J Autoimmun. 2012 Sep;39(3):234-9
references.pmid: 22835660
references.citation: Autoimmun Rev. 2013 Jan;12(3):380-95
references.pmid: 22743032
references.citation: Autoimmun Rev. 2010 Nov;10(1):8-17
references.pmid: 20678591
references.citation: BMC Med. 2013 Mar 18;11:73
references.pmid: 23497011
references.citation: BMC Med. 2013 Apr 04;11:99
references.pmid: 23557144
references.citation: Clin Rev Allergy Immunol. 2010 Apr;38(2-3):163-8
references.pmid: 19548122
references.citation: Front Biosci (Elite Ed). 2009 Jun 01;1:501-9
references.pmid: 19482664
references.citation: Nat Mater. 2010 Aug;9(8):607-8
references.pmid: 20651797
references.citation: Autoimmun Rev. 2012 Sep;11(11):781-4
references.pmid: 22353402
references.citation: Nature. 2012 Aug 30;488(7413):675-9
references.pmid: 22914092
references.citation: BMC Med. 2013 Apr 04;11:98
references.pmid: 23557114
references.citation: J Autoimmun. 2011 Feb;36(1):4-8
references.pmid: 20708902
references.citation: Nat Med. 2013 Feb;19(2):139-41
references.pmid: 23389609
references.citation: Semin Arthritis Rheum. 2006 Jun;35(6):341-3
references.pmid: 16765709
references.citation: BMC Med. 2013 Apr 04;11:100
references.pmid: 23557436
references.citation: BMC Med. 2013 Apr 04;11:97
references.pmid: 23557090
references.citation: Isr Med Assoc J. 2008 Jan;10(1):37-9
references.pmid: 18300569
references.citation: Expert Rev Clin Immunol. 2013 May;9(5):397-9
references.pmid: 23634733
references.citation: BMC Med. 2013 Apr 04;11:90
references.pmid: 23556432
references.citation: BMC Med. 2012 Jul 06;10:69
references.pmid: 22764877