title: Regulation of feeding behavior, gastrointestinal function and fluid homeostasis by apelin.
abstract: Apelin was first identified and characterized from bovine stomach extracts as an endogenous ligand for the APJ receptor. Apelin/APJ system is abundantly present in peripheral tissues and central nervous system. Apelin plays a broad role in regulating physiological and pathological functions. Recently, many reports have showed the effects of apelin on feeding behavior, however the results are inconsistent, due to different administration routes, animal species, forms of apelin, etc. Apelin has been involved in stimulating gastric cell proliferation, cholecystokinin (CCK) secretion, histamine release, gastric acid and bicarbonate secretion, and regulation of gastrointestinal motility. In addition, apelin produced regulatory effects on drinking behavior, diuresis, arginine vasopressin (AVP) release and glucocorticoids secretion. This article reviews the role of apelin on feeding behavior, gastrointestinal function and fluid homeostasis.
authors.affiliation: Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tianshui South Road, Lanzhou, Gansu 730000, China.
authors.forename: Shuang-Yu
authors.initials: SY
authors.lastname: Lv
authors.forename: Yan-Jie
authors.initials: YJ
authors.lastname: Yang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D000073861:Apelin; D001834:Body Water / Q000378:metabolism*; D049109:Cell Proliferation; D002766:Cholecystokinin / Q000378:metabolism; D004231:Diuresis; D005247:Feeding Behavior; D041981:Gastrointestinal Tract / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D006636:Histamine Release; D006706:Homeostasis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins; D002766:Cholecystokinin