title: Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats.
abstract: OBJECTIVE
  To investigate the possible protective effect of coenzyme Q10 (CQ10) on neuropathy in rats.
  
  
  METHODS
  Experiments were conducted in the Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey between January and March 2012. Forty rats were divided into 4 groups: group 1 (control), group 2 (paclitaxel), group 3 (control + CQ10), and group 4 (paclitaxel + CQ10). Group 2 and 4 rats received paclitaxel (2 mg/kg, intraperitoneally, on days 0, 2, 4, 6). Group 3 and 4 rats were treated with CQ10 (10 mg/kg, intraperitoneally, on days 0, 1, 2, 3, 4, 5, 6, 7, 8, 9). The rats that did not receive paclitaxel or CQ10 received vehicle. Mechanical allodynia tests were performed for each animal on day 0, 2, 6, 8, 10, 14, 16, 19, 39 and 41 for all groups with von Frey filaments.
  
  
  RESULTS
  At day 0, mean mechanical withdrawal thresholds were similar among all groups. Starting from day 2, the threshold of the paclitaxel group decreased. Starting from day 10, paclitaxel+CQ10 treated rats had significantly higher thresholds compared with the paclitaxel group, but these values were still significantly lower than that of the controls. Control and control + CQ10 rats had similar threshold values during the protocol.
  
  
  CONCLUSIONS
  The CQ10 treatment decreased the degree of paclitaxel-induced peripheral neuropathy in rats.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Samanpazari 06100, Ankara, Turkey. nalancelebi@gmail.com
authors.forename: Nalan
authors.initials: N
authors.lastname: Celebi
authors.forename: Hemra
authors.initials: H
authors.lastname: Cil
authors.forename: Onur
authors.initials: O
authors.lastname: Cil
authors.forename: Ozgur
authors.initials: O
authors.lastname: Canbay
authors.forename: Rustu
authors.initials: R
authors.lastname: Onur
authors.forename: Ulku
authors.initials: U
authors.lastname: Aypar
mesh_terms: D000818:Animals; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D017239:Paclitaxel; D017288:Pain Threshold / Q000187:drug effects*; D010812:Physical Stimulation; D011115:Polyneuropathies / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014110:Touch / Q000187:drug effects; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D014451:Ubiquinone; C024989:coenzyme Q10; D017239:Paclitaxel