title: [Function and role of transient receptor potential channels].
abstract: Transient receptor potential (TRP) proteins are components of Ca(2 +) -permeable non-selective cation channels activated by physical and chemical stimulus except for membrane depolarization. The pathophysiological role of TRP channels is documented in heart failure. Especially, canonical TRP subfamily C (TRPC) channels activated by neurohumoral factors have been implicated in the structural remodeling of the heart. TRPC proteins act not only as components of receptor-activated cation channels, but also as protein scaffold to form protein complex with intracellular signaling proteins, leading to amplification of receptor signaling. Recently, selective inhibitors of TRPC channels have been continuously identified, anticipating the possibility of drug discovery targeting TRPC channels for the treatment of heart failure.
authors.affiliation: Department of Drug Discovery and Evolution, Kyushu University, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Nishida
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sumita
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kitajima
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D017136:Ion Transport / Q000502:physiology*; D050051:Transient Receptor Potential Channels / Q000378:metabolism*; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D015220:Calcium Channels; D050051:Transient Receptor Potential Channels; D002118:Calcium