title: Recent developments in design and synthesis of bicyclic azasugars, carbasugars and related molecules as glycosidase inhibitors.
abstract: The importance of glycosidase inhibitors and especially the bicyclic molecules has led to design and assessment of many analogs of naturally occurring molecules. This review focuses on the synthesis and enzyme inhibitions of a few selected (synthetic or non-naturally occurring) molecules that have been reported in the last decade, which allow one to draw some connection between varying the structural features and their effect on glycosidase inhibitions. It is expected that further improvements based on these features could lead to improved inhibitors.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kanpur-208016, India.
authors.forename: Rima
authors.initials: R
authors.lastname: Lahiri
authors.forename: Alafia A
authors.initials: AA
authors.lastname: Ansari
authors.forename: Yashwant D
authors.initials: YD
authors.lastname: Vankar
mesh_terms: D053961:Azabicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D054329:Carbasugars / Q000138:chemical synthesis* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D054836:Indolizidines / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D053961:Azabicyclo Compounds; D054329:Carbasugars; D004791:Enzyme Inhibitors; D054836:Indolizidines; D006026:Glycoside Hydrolases