title: Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity.
abstract: Our research proved that chemical character of the C-5 substituent significantly determines the antibacterial activity of the Mannich bases derived from 4,5-disubstituted 1,2,4-triazole-3-thiones. This activity was considerably increased by an introduction of a chlorine atom to the phenyl ring. The obtained compounds were particularly active against opportunistic bacteria (Bacillus subtilisandBacilluscereus). The antibacterial activity of some Mannich bases was similar or higher than the activity of commonly used antibiotics such as ampicillin and cefuroxime.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Chodzki 4A, 20-093 Lublin, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Plech
authors.forename: Monika
authors.initials: M
authors.lastname: Wujec
authors.forename: Magdalena
authors.initials: M
authors.lastname: Majewska
authors.forename: Urszula
authors.initials: U
authors.lastname: Kosikowska
authors.forename: Anna
authors.initials: A
authors.lastname: Malm
keywords: Aminomethylation; Five-membered ring; MRSA; Opportunistic bacteria
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