title: Complex marine natural products as potential epigenetic and production regulators of antibiotics from a marine Pseudomonas aeruginosa.
abstract: Marine microbes are capable of producing secondary metabolites for defense and competition. Factors exerting an impact on secondary metabolite production of microbial communities included bioactive natural products and co-culturing. These external influences may have practical applications such as increased yields or the generation of new metabolites from otherwise silent genes in addition to reducing or limiting the production of undesirable metabolites. In this paper, we discuss the metabolic profiles of a marine Pseudomonas aeruginosa in the presence of a number of potential chemical epigenetic regulators, adjusting carbon sources and co-culturing with other microbes to induce a competitive response. As a result of these stressors certain groups of antibiotics or antimalarial agents were increased most notably when treating P. aeruginosa with sceptrin and co-culturing with another Pseudomonas sp. An interesting cross-talking event between these two Pseudomonas species when cultured together and exposed to sceptrin was observed.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Waters
authors.forename: James W
authors.initials: JW
authors.lastname: Sims
authors.forename: Alexis
authors.initials: A
authors.lastname: Fullmer
authors.forename: Serena
authors.initials: S
authors.lastname: Ellison
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis / Q000378:metabolism*; D001688:Biological Products / Q000032:analysis / Q000378:metabolism*; D057890:Epigenomics; D019015:Geologic Sediments / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism*; D012623:Seawater / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products
references.citation: J Chem Ecol. 2002 Oct;28(10):1971-85
references.pmid: 12474894
references.citation: Environ Microbiol. 2007 Nov;9(11):2683-93
references.pmid: 17922753
references.citation: Mol Microbiol. 2008 Jul;69(1):10-4
references.pmid: 18452582
references.citation: Microbiol Mol Biol Rev. 2006 Sep;70(3):830-56
references.pmid: 16959970
references.citation: J Nat Prod. 2007 Jun;70(6):941-7
references.pmid: 17511504
references.citation: FEMS Microbiol Rev. 2004 Jun;28(3):261-89
references.pmid: 15449604
references.citation: Microb Ecol. 2001 Feb;41(2):90-96
references.pmid: 12032613
references.citation: In Vitro Cell Dev Biol. 1990 Nov;26(11):1030-4
references.pmid: 2177465
references.citation: Curr Opin Microbiol. 2010 Jun;13(3):263-73
references.pmid: 20303823
references.citation: BMC Evol Biol. 2008 Feb 18;8:52
references.pmid: 18282299
references.citation: Mol Pharmacol. 2005 Aug;68(2):502-10
references.pmid: 15908515
references.citation: Org Biomol Chem. 2008 Jun 7;6(11):1895-7
references.pmid: 18480899
references.citation: Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1743-52
references.pmid: 22586093
references.citation: Arch Biochem Biophys. 1965 Aug;111(2):415-21
references.pmid: 4285853
references.citation: ACS Chem Biol. 2010 Feb 19;5(2):195-202
references.pmid: 20030414
references.citation: BMC Infect Dis. 2010 Jun 02;10:148
references.pmid: 20525206
references.citation: Mol Microbiol. 2002 Nov;46(4):905-15
references.pmid: 12421299
references.citation: J Nat Prod. 2007 Sep;70(9):1397-405
references.pmid: 17708655
references.citation: J Bacteriol. 2001 Sep;183(18):5376-84
references.pmid: 11514523
references.citation: Appl Microbiol Biotechnol. 2009 May;83(1):19-25
references.pmid: 19305992
references.citation: J Nat Prod. 2007 Apr;70(4):515-20
references.pmid: 17323993
references.citation: Mol Biosyst. 2011 Apr;7(4):1205-16
references.pmid: 21258753
references.citation: Am J Trop Med Hyg. 1993 Jun;48(6):739-41
references.pmid: 8333566
references.citation: Biotechniques. 2012 Mar;52(3):167-72
references.pmid: 22401549