title: Medicinal flowers. XXXVIII. structures of acylated sucroses and inhibitory effects of constituents on aldose reducatase from the flower buds of Prunus mume.
abstract: The methanolic extract from the flower buds of Prunus mume, cultivated in Zhejiang province, China, showed an inhibitory effect on aldose reductase. From the methanolic extract, five new acylated sucroses, mumeoses F-J, were isolated together with 29 known compounds. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated compounds on aldose reductase were also investigated. Acylated quinic acid analogs, which are one of the major compounds of the flower buds of P. mume, were shown to substantially inhibit aldose reductase. In particular, mumeic acid-A was found to exhibit a potent inhibitory effect [IC50=0.4 µm].
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Tomoe
authors.initials: T
authors.lastname: Ohta
authors.forename: Keiko
authors.initials: K
authors.lastname: Ogawa
authors.forename: Haruka
authors.initials: H
authors.lastname: Tamura
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000215:Acylation; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D035264:Flowers / Q000737:chemistry; D007904:Lens Cortex, Crystalline / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry* / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry*; D011485:Protein Binding; D027861:Prunus / Q000737:chemistry*; D011801:Quinic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D051381:Rats; D013395:Sucrose / Q000737:chemistry* / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D011801:Quinic Acid; D013395:Sucrose; D000449:Aldehyde Reductase; D000432:Methanol