title: Catalytic asymmetric synthesis of γ-butenolides by direct vinylogous reactions.
abstract: The γ-butenolide structural motif is a prominent feature in many bioactive natural products and drugs. This short review summarizes catalytic asymmetric synthesis of γ-butenolides through direct vinylogous reactions by metal complexes and organocatalysts. In light of building chiral γ-tertiary and quaternary carbon centers of butenolides, three synthetic strategies are included: 1) the reactions with furanone derivatives as nucleophiles, 2) olefination of γ,γ- disubstituted butenolides and 3) the reactions by using γ,γ-disubstituted butenolides as nucleophiles.
authors.affiliation: Institute of Chemical Biology, Henan University, Kaifeng, Henan 475004, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yan
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wu
authors.forename: Hongjun
authors.initials: H
authors.lastname: Liu
authors.forename: Liangying
authors.initials: L
authors.lastname: Xie
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000475:Alkenes; D056831:Coordination Complexes; D005663:Furans; C004511:butenolide; D015107:4-Butyrolactone