title: Pulmonary function in ankylosing spondylitis: association with clinical variables.
abstract: To evaluate the association between pulmonary function and clinical variables in ankylosing spondylitis (AS) and to compare the pulmonary function of patients with AS with that of healthy controls, 61 AS patients and 74 healthy controls were included. In AS, we assessed clinical disease indices (BASDAI, BASFI, BASG), morning stiffness, number of hypersensitive entheses, metrology measures, 6-min walking test, acute phase reactants, radiological presence of "bamboo spine," and severity of radiological involvement in sacroiliac and vertebral joints. AS and healthy controls had similar age and gender. All the parameters of pulmonary function were significantly diminished in AS than in healthy controls (p < 0.001), with a higher proportion of restrictive pattern (57.4 vs. 5.4 %). In AS, pulmonary function correlated negatively with BASDAI, BASFI, BASG, morning stiffness, number of hypersensitive entheses, occiput-wall distance, and ESR, and positively with 6-min walking test. There was no association between pulmonary function with radiological stage of vertebral joints and sacroiliac joints, "bamboo spine," disease duration, or chest expansion. A higher frequency of AS patients had a decreased pulmonary function and results of the 6-min walking test. These abnormalities in AS were more related with disease activity than with mobility limitation.
authors.affiliation: Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
authors.forename: A J L
authors.initials: AJ
authors.lastname: Brambila-Tapia
authors.forename: A D
authors.initials: AD
authors.lastname: Rocha-Muñoz
authors.forename: L
authors.initials: L
authors.lastname: Gonzalez-Lopez
authors.forename: M
authors.initials: M
authors.lastname: Vázquez-Del-Mercado
authors.forename: M
authors.initials: M
authors.lastname: Salazar-Páramo
authors.forename: I P
authors.initials: IP
authors.lastname: Dávalos-Rodríguez
authors.forename: L
authors.initials: L
authors.lastname: De la Cerda-Trujillo
authors.forename: M L
authors.initials: ML
authors.lastname: Diaz-Toscano
authors.forename: P
authors.initials: P
authors.lastname: Hernandez-Cuervo
authors.forename: V
authors.initials: V
authors.lastname: Diaz-Rizo
authors.forename: D
authors.initials: D
authors.lastname: Sanchez-Mosco
authors.forename: J C
authors.initials: JC
authors.lastname: Vazquez-Jimenez
authors.forename: E G
authors.initials: EG
authors.lastname: Cardona-Muñoz
authors.forename: J I
authors.initials: JI
authors.lastname: Gamez-Nava
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001799:Blood Sedimentation; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000188:drug therapy / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014797:Vital Capacity; D016138:Walking
chemical_list: D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha
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