title: Fabrication of magnetic-antimicrobial-fluorescent multifunctional hybrid microspheres and their properties.
abstract: Novel magnetic-antimicrobial-fluorescent multifunctional hybrid microspheres with well-defined nanostructure were synthesized by the aid of a poly(glycidyl methacrylate) (PGMA) template. The hybrid microspheres were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR), X-ray diffraction (XRD) and digital fluorescence microscope. The as-synthesized microspheres PGMA, amino-modified PGMA (NH2-PGMA) and magnetic PGMA (M-PGMA) have a spherical shape with a smooth surface and fine monodispersity. M-PGMA microspheres are super-paramagnetic, and their saturated magnetic field is 4.608 emu·g-1, which made M-PGMA efficiently separable from aqueous solution by an external magnetic field. After poly(haxemethylene guanidine hydrochloride) (PHGH) functionalization, the resultant microspheres exhibit excellent antibacterial performance against both Gram-positive and Gram-negative bacteria. The fluorescence feature originating from the quantum dot CdTe endowed the hybrid microspheres with biological functions, such as targeted localization and biological monitoring functions. Combination of magnetism, antibiosis and fluorescence into one single hybrid microsphere opens up the possibility of the extensive study of multifunctional materials and widens the potential applications.
authors.affiliation: College of Chemistry and MacDiarmid Laboratory, Jilin University, Changchun 130021, China. gaoge8888@gmail.com.
authors.forename: Ling-Han
authors.initials: LH
authors.lastname: Xiao
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Tian-Yi
authors.initials: TY
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Zheng
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Sun
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Feng-Qi
authors.initials: FQ
authors.lastname: Liu
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.forename: Alideertu
authors.initials: A
authors.lastname: Dong
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000254:growth & development*; D006094:Gram-Positive Bacteria / Q000254:growth & development*; D008280:Magnetics; D008863:Microspheres; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D005456:Fluorescent Dyes; D011109:Polymethacrylic Acids; C042535:polyglycidyl methacrylate
references.citation: Biomacromolecules. 2007 May;8(5):1359-84
references.pmid: 17425365
references.citation: J Am Chem Soc. 2006 Jul 19;128(28):8998-9
references.pmid: 16834349
references.citation: Chem Commun (Camb). 2008 Nov 14;(42):5342-4
references.pmid: 18985204
references.citation: Microbios. 1984;41(163):15-22
references.pmid: 6396498
references.citation: Nanotechnology. 2009 May 27;20(21):215302
references.pmid: 19423928
references.citation: Langmuir. 2010 Jan 19;26(2):1278-84
references.pmid: 19775134
references.citation: Chem Commun (Camb). 2008 Nov 21;(43):5577-9
references.pmid: 18997957
references.citation: Chem Commun (Camb). 2007 Nov 28;(44):4677-9
references.pmid: 17989830
references.citation: J Am Chem Soc. 2009 Jan 14;131(1):182-8
references.pmid: 19055347
references.citation: Angew Chem Int Ed Engl. 2008;47(5):960-2
references.pmid: 18092310
references.citation: Langmuir. 2010 Sep 21;26(18):14806-13
references.pmid: 20795688
references.citation: Ind Eng Chem Res. 2006;45(8):2634-2640
references.pmid: 18714370
references.citation: Small. 2006 Apr;2(4):476-80
references.pmid: 17193069
references.citation: Anal Biochem. 2010 Oct 15;405(2):207-12
references.pmid: 20599531
references.citation: J Appl Bacteriol. 1984 Aug;57(1):115-24
references.pmid: 6386785
references.citation: Chem Rev. 2008 Sep;108(9):3893-957
references.pmid: 18720998