title: Results of single-center screening for chronic hepatitis E in children after liver transplantation and report on successful treatment with ribavirin.
abstract: RNA screening for HEV in 22 liver-transplanted children with chronic graft hepatitis out of a cohort of 267 liver-transplanted children detected a single patient with chronic HEV infection. Although this patient remained viremic for 33 months, anti-HEV-IgG was not detectable with MP assay but with Wantai assay. We present the first case of successful ribavirin therapy in an immunosuppressed child with chronic HEV infection. In conclusion, chronic HEV infection in immunosuppressed children may not be detectable employing serological assays. Therefore, the most reliably screening method is screening for HEV-RNA. Chronic HEV infection in children can successfully be treated with ribavirin.
authors.affiliation: Pediatric Gastroenterology and Hepatology, Children's Hospital, Hannover Medical School, Hannover, Germany. Junge.Norman@mh-hannover.de
authors.forename: Norman
authors.initials: N
authors.lastname: Junge
authors.forename: Sven
authors.initials: S
authors.lastname: Pischke
authors.forename: Ulrich
authors.initials: U
authors.lastname: Baumann
authors.forename: Imeke
authors.initials: I
authors.lastname: Goldschmidt
authors.forename: Michael
authors.initials: M
authors.lastname: Manns
authors.forename: Heiner
authors.initials: H
authors.lastname: Wedemeyer
authors.forename: Eva-Doreen
authors.initials: ED
authors.lastname: Pfister
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006505:Hepatitis / Q000209:etiology / Q000821:virology*; D016751:Hepatitis E / Q000175:diagnosis* / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007223:Infant; D017093:Liver Failure / Q000150:complications / Q000628:therapy*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D016133:Polymerase Chain Reaction; D011183:Postoperative Complications; D012367:RNA, Viral / Q000032:analysis; D012189:Retrospective Studies; D012254:Ribavirin / Q000627:therapeutic use*
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D012367:RNA, Viral; D012254:Ribavirin