title: [An update on neuropsychiatric lupus with emphasis in cognitive dysfunction].
abstract: Patients with systemic lupus erythematosus (SLE) suffer from a number of neuropsychiatric (NP) symptoms throughout their disease affecting them both physically and psychologically. We review herein the nomenclature and case definitions for neuropsychiatric lupus syndromes proposed by the American College of Rheumatology in 1999. We emphasize cognitive dysfunction and discuss etiological hypotheses, especially those related to the presence of antineuronal autoantibodies.
authors.affiliation: Departamentos de Inmunología Clínica y Reumatología y Psiquiatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Tomás
authors.initials: T
authors.lastname: León
authors.forename: Carla
authors.initials: C
authors.lastname: Henríquez
authors.forename: Jorge
authors.initials: J
authors.lastname: Calderón
authors.forename: Loreto
authors.initials: L
authors.lastname: Massardo
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D003072:Cognition Disorders / Q000276:immunology / Q000503:physiopathology; D003863:Depression / Q000209:etiology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology / Q000523:psychology
chemical_list: D001323:Autoantibodies