title: Regulation network analysis of testicular seminoma at various stages of progression.
abstract: Testicular seminoma has become the most common solid malignancy in young men, especially in the 20s group. We obtained the gene expression profile of human testicular seminoma cells from NCBI, identified the differentially expressed genes of testicular seminoma cells of different stages, and constructed the regulation networks of different stages of testicular seminoma using bioinformatics methodology. Forty differentially expressed genes of testicular seminoma cells of different stages were identified. These genes and pathways are apparently involved in the progression of testicular seminoma.
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Sha
authors.forename: Y-H
authors.initials: YH
authors.lastname: Dong
authors.forename: D-M
authors.initials: DM
authors.lastname: Liu
authors.forename: J-J
authors.initials: JJ
authors.lastname: Bo
authors.forename: Y-R
authors.initials: YR
authors.lastname: Huang
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: P
authors.initials: P
authors.lastname: Ping
mesh_terms: D016022:Case-Control Studies; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D018239:Seminoma / Q000378:metabolism* / Q000473:pathology; D013736:Testicular Neoplasms / Q000378:metabolism* / Q000473:pathology; D013737:Testis / Q000378:metabolism / Q000473:pathology; D059467:Transcriptome; D015854:Up-Regulation