title: Interhemispheric functional connectivity following prenatal or perinatal brain injury predicts receptive language outcome.
abstract: Early brain injury alters both structural and functional connectivity between the cerebral hemispheres. Despite increasing knowledge on the individual hemispheric contributions to recovery from such injury, we know very little about how their interactions affect this process. In the present study, we related interhemispheric structural and functional connectivity to receptive language outcome following early left hemisphere stroke. We used functional magnetic resonance imaging to study 14 people with neonatal brain injury, and 25 age-matched controls during passive story comprehension. With respect to structural connectivity, we found that increased volume of the corpus callosum predicted good receptive language outcome, but that this is not specific to people with injury. In contrast, we found that increased posterior superior temporal gyrus interhemispheric functional connectivity during story comprehension predicted better receptive language performance in people with early brain injury, but worse performance in typical controls. This suggests that interhemispheric functional connectivity is one potential compensatory mechanism following early injury. Further, this pattern of results suggests refinement of the prevailing notion that better language outcome following early left hemisphere injury relies on the contribution of the contralesional hemisphere (i.e., the "right-hemisphere-take-over" theory). This pattern of results was also regionally specific; connectivity of the angular gyrus predicted poorer performance in both groups, independent of brain injury. These results present a complex picture of recovery, and in some cases, such recovery relies on increased cooperation between the injured hemisphere and homologous regions in the contralesional hemisphere, but in other cases, the opposite appears to hold.
authors.affiliation: Department of Psychology, Florida International University, Miami, Florida 33199, USA. adick@fiu.edu
authors.forename: Anthony Steven
authors.initials: AS
authors.lastname: Dick
authors.forename: Anjali
authors.initials: A
authors.lastname: Raja Beharelle
authors.forename: Ana
authors.initials: A
authors.lastname: Solodkin
authors.forename: Steven L
authors.initials: SL
authors.lastname: Small
mesh_terms: D000293:Adolescent; D000328:Adult; D001284:Atrophy; D016022:Case-Control Studies; D020214:Cerebrovascular Trauma / Q000150:complications / Q000473:pathology*; D002648:Child; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology; D032882:Comprehension / Q000502:physiology*; D003337:Corpus Callosum / Q000098:blood supply / Q000473:pathology; D002658:Developmental Disabilities / Q000209:etiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007360:Intelligence; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011237:Predictive Value of Tests; D011712:Pyramidal Tracts / Q000098:blood supply / Q000473:pathology*; D013223:Statistics as Topic; D014855:Wallerian Degeneration / Q000209:etiology / Q000473:pathology; D055815:Young Adult
chemical_list: D010100:Oxygen
references.citation: Brain. 2011 Aug;134(Pt 8):2197-221
references.pmid: 21784775
references.citation: PLoS Comput Biol. 2009 Jun;5(6):e1000408
references.pmid: 19521503
references.citation: Child Neuropsychol. 2007 Nov;13(6):494-509
references.pmid: 17852133
references.citation: Hum Brain Mapp. 2008 May;29(5):581-93
references.pmid: 17557297
references.citation: Neuroimage. 2010 Oct 15;53(1):139-45
references.pmid: 20542120
references.citation: Curr Opin Neurol. 2002 Apr;15(2):133-8
references.pmid: 11923625
references.citation: Brain. 2006 Jun;129(Pt 6):1371-84
references.pmid: 16638796
references.citation: Neuropsychology. 2002 Jan;16(1):56-64
references.pmid: 11858226
references.citation: Hum Brain Mapp. 2008 Jul;29(7):802-9
references.pmid: 18438885
references.citation: Neurobiol Aging. 2001 Jul-Aug;22(4):603-11
references.pmid: 11445261
references.citation: Neuron. 2007 Dec 20;56(6):1116-26
references.pmid: 18093531
references.citation: Neuroimage. 2002 Apr;15(4):870-8
references.pmid: 11906227
references.citation: Neuroimage. 2006 Sep;32(3):989-94
references.pmid: 16854598
references.citation: Dev Sci. 2012 Mar;15(2):165-80
references.pmid: 22356173
references.citation: Cereb Cortex. 2010 Mar;20(3):633-40
references.pmid: 19561061
references.citation: Brain. 2012 Dec;135(Pt 12):3781-98
references.pmid: 23144265
references.citation: Cereb Cortex. 2011 Feb;21(2):459-66
references.pmid: 20566580
references.citation: Brain. 2011 May;134(Pt 5):1264-76
references.pmid: 21414995
references.citation: J Neurosci. 2008 Jun 18;28(25):6453-8
references.pmid: 18562616
references.citation: Ann Neurol. 2010 Mar;67(3):365-75
references.pmid: 20373348
references.citation: Neuropediatrics. 2000 Oct;31(5):257-64
references.pmid: 11204283
references.citation: Trends Cogn Sci. 2005 Mar;9(3):136-43
references.pmid: 15737822
references.citation: AJNR Am J Neuroradiol. 2001 Sep;22(8):1483-9
references.pmid: 11559495
references.citation: Brain. 1989 Jun;112 ( Pt 3):799-835
references.pmid: 2731030
references.citation: Nat Rev Neurosci. 2008 Aug;9(8):613-25
references.pmid: 18641668
references.citation: Neurology. 2000 Dec 26;55(12):1883-94
references.pmid: 11134389
references.citation: Brain Cogn. 2008 Jul;67(2):225-33
references.pmid: 18346830
references.citation: Cereb Cortex. 2009 Dec;19(12):2767-96
references.pmid: 19329570
references.citation: Hum Brain Mapp. 2006 Oct;27(10):779-88
references.pmid: 16456818
references.citation: Neurology. 2001 Jul 10;57(1):122-5
references.pmid: 11445639
references.citation: J Int Neuropsychol Soc. 2007 May;13(3):505-16
references.pmid: 17445300
references.citation: J Anat. 2010 Oct;217(4):469-74
references.pmid: 20649910
references.citation: Curr Opin Neurol. 2005 Aug;18(4):429-34
references.pmid: 16003120
references.citation: Neuropediatrics. 1994 Apr;25(2):60-6
references.pmid: 8072676
references.citation: J Neurosci. 2001 Feb 15;21(4):1302-12
references.pmid: 11160401
references.citation: Brain. 2010 Apr;133(Pt 4):1224-38
references.pmid: 20354002
references.citation: Ann Neurol. 2008 Feb;63(2):236-46
references.pmid: 17896791
references.citation: Brain. 1994 Feb;117 ( Pt 1):105-15
references.pmid: 8149205
references.citation: Nature. 2009 Oct 15;461(7266):983-6
references.pmid: 19829380
references.citation: Neurosci Biobehav Rev. 2007;31(8):1136-49
references.pmid: 18053875
references.citation: Brain Lang. 2008 Sep;106(3):165-6
references.pmid: 18571227
references.citation: Neurology. 1997 Apr;48(4):1003-12
references.pmid: 9109891
references.citation: Neuroimage. 2007 Jan 1;34(1):349-60
references.pmid: 17064940
references.citation: Brain Res. 1998 Nov 23;812(1-2):38-49
references.pmid: 9813233
references.citation: Behav Neurosci. 1992 Feb;106(1):3-14
references.pmid: 1554435
references.citation: Front Syst Neurosci. 2011 Feb 10;5:1
references.pmid: 21347218
references.citation: Brain. 2002 Feb;125(Pt 2):361-72
references.pmid: 11844736
references.citation: J Neurosci. 2010 Dec 15;30(50):16809-17
references.pmid: 21159952
references.citation: Brain Lang. 1998 Feb 15;61(3):335-75
references.pmid: 9570869
references.citation: J Child Neurol. 2002 Oct;17(10):766-9
references.pmid: 12546432
references.citation: Neuroimage. 2010 Oct 1;52(4):1224-9
references.pmid: 20553894
references.citation: Nature. 1979 Jul 19;280(5719):231-4
references.pmid: 450139
references.citation: Brain Lang. 2010 Aug;114(2):135-46
references.pmid: 19819000
references.citation: Neuroimage. 1999 Feb;9(2):179-94
references.pmid: 9931268
references.citation: Nat Rev Neurosci. 2005 Dec;6(12):955-65
references.pmid: 16288299
references.citation: J Anat. 2006 Sep;209(3):311-20
references.pmid: 16928200
references.citation: Brain Lang. 2001 Nov;79(2):223-65
references.pmid: 11712846
references.citation: Neuron. 2007 Jan 4;53(1):135-45
references.pmid: 17196536
references.citation: J Cogn Neurosci. 2010 Aug;22(8):1662-9
references.pmid: 19583478
references.citation: Brain Res. 1988 Jan 12;438(1-2):216-24
references.pmid: 3345428
references.citation: Trends Cogn Sci. 2011 Nov;15(11):527-36
references.pmid: 22001867
references.citation: Ann Neurol. 1996 Jul;40(1):31-8
references.pmid: 8687189
references.citation: PLoS One. 2011;6(6):e20726
references.pmid: 21695183
references.citation: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
references.pmid: 15976020
references.citation: Neuropsychologia. 2004;42(2):257-71
references.pmid: 14644111
references.citation: Neuroimage. 2008 Jan 15;39(2):693-706
references.pmid: 17964812
references.citation: Ann Neurol. 1978 Mar;3(3):273-80
references.pmid: 666267
references.citation: Science. 1970 Nov 27;170(3961):940-4
references.pmid: 5475022
references.citation: Neurosci Lett. 1994 Nov 21;182(1):25-8
references.pmid: 7891880
references.citation: Neuroimage. 2013 Aug 1;76:439-41
references.pmid: 22440651
references.citation: Neuroimage. 2006 Jul 1;31(3):968-80
references.pmid: 16530430
references.citation: J Prim Prev. 2009 Sep;30(5):497-512
references.pmid: 19685290
references.citation: Brain Res. 1988 May 31;450(1-2):1-8
references.pmid: 3401704
references.citation: Brain. 2010 Jun;133(Pt 6):1707-16
references.pmid: 20466762
references.citation: Brain. 1993 Oct;116 ( Pt 5):1223-47
references.pmid: 8221056
references.citation: Arch Neurol. 2008 Jun;65(6):741-7
references.pmid: 18541794
references.citation: Neuroimage. 2004 Aug;22(4):1732-43
references.pmid: 15275929
references.citation: Cereb Cortex. 2004 Jan;14(1):11-22
references.pmid: 14654453
references.citation: Neuroimage. 1997 Aug;6(2):93-103
references.pmid: 9299383
references.citation: Brain Res. 1984 Apr 2;296(2):365-9
references.pmid: 6704743
references.citation: Neuroimage. 2005 Mar;25(1):76-89
references.pmid: 15734345
references.citation: AJNR Am J Neuroradiol. 2003 Feb;24(2):208-12
references.pmid: 12591635
references.citation: Cereb Cortex. 2000 Dec;10(12):1200-10
references.pmid: 11073869
references.citation: Cereb Cortex. 2009 Jun;19(6):1322-9
references.pmid: 18842665
references.citation: Neuroimage. 2002 Aug;16(4):954-67
references.pmid: 12202083
references.citation: Eur J Neurol. 2005 Apr;12(4):268-75
references.pmid: 15804243
references.citation: Curr Biol. 2009 Apr 28;19(8):661-7
references.pmid: 19327997
references.citation: Pediatrics. 2007 Sep;120(3):609-16
references.pmid: 17766535
references.citation: Neuroscientist. 2000 Feb;6(1):5-13
references.pmid: 18461153
references.citation: J Neurosci. 1997 Jan 1;17(1):353-62
references.pmid: 8987760
references.citation: J Neuropathol Exp Neurol. 1985 Nov;44(6):578-91
references.pmid: 4056827
references.citation: J Child Neurol. 2002 Dec;17(12):885-90
references.pmid: 12593460
references.citation: Neuropsychologia. 1971 Mar;9(1):97-113
references.pmid: 5146491
references.citation: Biol Psychiatry. 2004 Jul 15;56(2):80-5
references.pmid: 15231439
references.citation: Cognition. 2004 May-Jun;92(1-2):145-77
references.pmid: 15037129
references.citation: Brain Lang. 2010 Aug;114(2):101-14
references.pmid: 19781755
references.citation: Neuroreport. 2007 Sep 17;18(14):1411-5
references.pmid: 17712265
references.citation: Cereb Cortex. 1992 Jul-Aug;2(4):277-94
references.pmid: 1422089
references.citation: Cereb Cortex. 2012 Feb;22(2):455-64
references.pmid: 21670100
references.citation: Cortex. 2011 Jan;47(1):59-80
references.pmid: 19833328
references.citation: Neuropsychol Rev. 2005 Jun;15(2):59-71
references.pmid: 16211466
references.citation: Hum Brain Mapp. 2009 Oct;30(10):3172-87
references.pmid: 19241418
references.citation: Brain Res. 1992 Dec 11;598(1-2):143-53
references.pmid: 1486477
references.citation: Brain. 2004 Jun;127(Pt 6):1229-36
references.pmid: 15069021
references.citation: Neuroimage. 2004 Oct;23(2):724-38
references.pmid: 15488422
references.citation: Cereb Cortex. 2010 Mar;20(3):534-48
references.pmid: 19520764
references.citation: Cognition. 1991 Jun;39(3):215-58
references.pmid: 1841034
references.citation: J Neurodev Disord. 2011 Mar;3(1):3-27
references.pmid: 21484594
references.citation: Hum Brain Mapp. 2009 Nov;30(11):3509-26
references.pmid: 19384890
references.citation: Arch Ital Biol. 2010 Sep;148(3):219-41
references.pmid: 21175010
references.citation: Cogn Psychol. 1989 Jan;21(1):60-99
references.pmid: 2920538
references.citation: Neuroimage. 2012 Feb 1;59(3):2142-54
references.pmid: 22019881
references.citation: Ann N Y Acad Sci. 1977 Sep 30;299:355-69
references.pmid: 101116
references.citation: Brain Lang. 1998 May;62(3):422-51
references.pmid: 9593617
references.citation: Ann N Y Acad Sci. 2010 Mar;1191:62-88
references.pmid: 20392276
references.citation: J Neurosci. 2002 Jan 15;22(2):455-63
references.pmid: 11784790
references.citation: Neurology. 1995 Feb;45(2):349-56
references.pmid: 7854538
references.citation: J Comput Assist Tomogr. 2004 Jul-Aug;28(4):533-9
references.pmid: 15232387
references.citation: Brain. 1985 Sep;108 ( Pt 3):677-96
references.pmid: 4041778
references.citation: Brain Lang. 2005 Apr;93(1):95-105
references.pmid: 15766771
references.citation: Ann Neurol. 1979 Nov;6(5):405-9
references.pmid: 92909
references.citation: J Child Neurol. 2007 Jul;22(7):841-7
references.pmid: 17715276
references.citation: Neuropsychologia. 1995 Jun;33(6):769-79
references.pmid: 7675166
references.citation: Neuroimage. 1999 Feb;9(2):195-207
references.pmid: 9931269