title: Toxicological evaluation of magnetic ionic liquids in human cell lines.
abstract: Magnetic ionic liquids (MILs) are new solvents with an interesting broad of applications however their toxicity is still an open issue. In this paper we report the toxicity of [C(8)MIM] and [Choline-C(n)] based magnetic ionic liquids assessed in two human cell lines: normal skin fibroblasts (CRL-1502) and colorectal adenocarcinoma cells (CaCo-2), acquiring this last characteristics of human enterocytes after differentiation. The results showed that [CoCl(4)] and [MnCl(4)] are more prone to generate cytotoxicity.
authors.affiliation: iMed.UL, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal. rfmf@ff.ul.pt
authors.forename: Raquel F M
authors.initials: RF
authors.lastname: Frade
authors.forename: Svilen
authors.initials: S
authors.lastname: Simeonov
authors.forename: Andreia A
authors.initials: AA
authors.lastname: Rosatella
authors.forename: Filipa
authors.initials: F
authors.lastname: Siopa
authors.forename: Carlos A M
authors.initials: CA
authors.lastname: Afonso
mesh_terms: D018938:Caco-2 Cells; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002712:Chlorides / Q000737:chemistry / Q000633:toxicity; D003035:Cobalt / Q000737:chemistry / Q000633:toxicity; D004785:Environmental Pollutants / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D052578:Ionic Liquids / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D008280:Magnetics; D017895:Manganese Compounds / Q000737:chemistry; D008956:Models, Chemical; D012997:Solvents / Q000737:chemistry
chemical_list: D002712:Chlorides; D004785:Environmental Pollutants; D052578:Ionic Liquids; D017895:Manganese Compounds; D012997:Solvents; D003035:Cobalt; C018021:cobaltous chloride; C025340:manganese chloride