title: Synthesis and anticancer evaluation of novel 3,5-diaryl-thiazolo[4,5-d]pyrimidin-2-one derivatives.
abstract: The 2-oxo analogs of thiazolo[4,5-d]pyrimidine-2-thiones were prepared to study their cytotoxic activity. Five of the newly synthesized compounds were selected by the National Cancer Institute (Bethesda, MD, USA) for a primary in vitro antitumor assay. 7-Chloro-3,5-diphenyl-thiazolo[4,5-d]pyrimidin-2-one (5a) proved to be the most active one among the screened derivatives and was further evaluated in the full panel of 60 cell lines at five different concentrations. The structures of compounds were determined by IR,1H-NMR,13C-NMR, X-ray, and elemental analysis.
authors.affiliation: Department of Drugs Technology, Wroclaw Medical University, Pl. Nankiera 1, 50-140 Wroclaw, Poland.
authors.forename: Lilianna
authors.initials: L
authors.lastname: Becan
authors.forename: Edwin
authors.initials: E
authors.lastname: Wagner
keywords: Antitumor agents; In vitro studies; Synthesis; Thiazolo[4,5-d]pyrimidin-2-ones
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