title: Reduced serum levels of neuron specific enolase (NSE) in drug-naïve subjects with major depression and bipolar disorder.
abstract: Several biological factors have been recently related with major depression and bipolar disorder. The aim of our paper was to investigate the peripheral levels of the protein neuronal specific enolase (NSE), a putative marker of neuronal damage, comparing patients with major depressive disorder and bipolar disorder to control subjects. This is a case-control study nested in a cross-sectional population-based survey. Psychopathology screen was performed using the Mini-International Neuropsychiatric Interview 5.0 and blood samples were collected from 108 young adults. Three groups were selected, 36 healthy controls, 36 subjects with major depression disorder and 36 subjects with bipolar disorder. Serum levels of NSE significantly decreased (p = 0.002) in major depression disorder (2.19 ± 1.78 ng/mL) and bipolar disorder subjects (2.53 ± 2.61 ng/mL) compared to the control group (3.55 ± 2.19 ng/mL). In conclusion, peripheral neuronal specific enolase may be a useful marker drug-naïve major depression disorder and bipolar disorder, but its pathophysiological significance and response to treatment should be further investigated.
authors.affiliation: Laboratório de Neurociências Clínicas, Centro de Ciências Da Vida E Da Saúde, Universidade Católica de Pelotas, Gonçalves Chaves, 373 Sala 324 Prédio C, Centro-Pelotas, 96015-560, RS, Brazil.
authors.forename: Carolina David
authors.initials: CD
authors.lastname: Wiener
authors.forename: Karen
authors.initials: K
authors.lastname: Jansen
authors.forename: Gabriele
authors.initials: G
authors.lastname: Ghisleni
authors.forename: Manuella Pinto
authors.initials: MP
authors.lastname: Kaster
authors.forename: Luciano Dias de Mattos
authors.initials: LD
authors.lastname: Souza
authors.forename: Diogo Rizzato
authors.initials: DR
authors.lastname: Lara
authors.forename: Luiz Valmor
authors.initials: LV
authors.lastname: Portela
authors.forename: Ricardo Azevedo
authors.initials: RA
authors.lastname: da Silva
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Oses
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001714:Bipolar Disorder / Q000097:blood*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010751:Phosphopyruvate Hydratase
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