title: Quercitrin protects skin from UVB-induced oxidative damage.
abstract: Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin.
authors.affiliation: Cancer Institute, The First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Yuanqin
authors.initials: Y
authors.lastname: Yin
authors.forename: Wenqi
authors.initials: W
authors.lastname: Li
authors.forename: Young-Ok
authors.initials: YO
authors.lastname: Son
authors.forename: Lijuan
authors.initials: L
authors.lastname: Sun
authors.forename: Jian
authors.initials: J
authors.lastname: Lu
authors.forename: Donghern
authors.initials: D
authors.lastname: Kim
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Yao
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Poyil
authors.initials: P
authors.lastname: Pratheeshkumar
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Hitron
authors.forename: Jia
authors.initials: J
authors.lastname: Luo
authors.forename: Ning
authors.initials: N
authors.lastname: Gao
authors.forename: Xianglin
authors.initials: X
authors.lastname: Shi
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002460:Cell Line; D004249:DNA Damage; D004260:DNA Repair; D000078404:Epidermal Cells; D005786:Gene Expression Regulation / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D016328:NF-kappa B; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D017382:Reactive Oxygen Species; D012867:Skin / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D000975:Antioxidants; D016328:NF-kappa B; D017382:Reactive Oxygen Species; C012526:quercitrin; D011794:Quercetin
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