title: Support Vector Machine based diagnostic system for thyroid cancer using statistical texture features.
abstract: OBJECTIVE
  The aim of this study was to develop an automated computer-aided diagnostic system for diagnosis of thyroid cancer pattern in fine needle aspiration cytology (FNAC) microscopic images with high degree of sensitivity and specificity using statistical texture features and a Support Vector Machine classifier (SVM).
  
  
  METHODS
  A training set of 40 benign and 40 malignant FNAC images and a testing set of 10 benign and 20 malignant FNAC images were used to perform the diagnosis of thyroid cancer. Initially, segmentation of region of interest (ROI) was performed by region-based morphology segmentation. The developed diagnostic system utilized statistical texture features derived from the segmented images using a Gabor filter bank at various wavelengths and angles. Finally, the SVM was used as a machine learning algorithm to identify benign and malignant states of thyroid nodules.
  
  
  RESULTS
  The SVMachieved a diagnostic accuracy of 96.7% with sensitivity and specificity of 95% and 100%, respectively, at a wavelength of 4 and an angle of 45.
  
  
  CONCLUSIONS
  The results show that the diagnosis of thyroid cancer in FNAC images can be effectively performed using statistical texture information derived with Gabor filters in association with an SVM.
authors.affiliation: Department of Electronics and Communication Engineering, Info Institute of Engineering, Coimbatore, India. gopiphd@yahoo.com
authors.forename: B
authors.initials: B
authors.lastname: Gopinath
authors.forename: N
authors.initials: N
authors.lastname: Shanthi
mesh_terms: D000465:Algorithms; D044963:Biopsy, Fine-Needle; D018276:Carcinoma, Medullary / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008853:Microscopy; D015233:Models, Statistical; D010363:Pattern Recognition, Automated / Q000379:methods*; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000473:pathology*