title: Protective effects of bilobalide on Aβ(25-35) induced learning and memory impairments in male rats.
abstract: Alzheimer's disease (AD) is one of the major neurological diseases of the elderly. The deposition of Aβ peptide, which can induce neuronal oxidative stress, inflammation and apoptosis, plays important roles in neuronal degeneration in AD. Currently, there are no effective drug treatment options for preventing or even slowing Alzheimer's disease. Bilobalide (BB) is one of the major active compounds extracted from Ginkgo biloba leaves. This study explored the neuroprotective effects of BB on Aβ25-35 intrahippocampal injection induced AD model in rats. Our results showed that BB (4, 8 mg/kg) significantly protected against learning and memory impairments induced by Aβ25-35 in Morris water maze. Besides, BB (4, 8 mg/kg) was able to attenuate the neuronal damage and apoptosis in frontal cortex and hippocampus CA1 in rats. In addition, the inhibition of TNF-α and Aβ1-40 expression is also involved in the action mechanisms of BB in this experimental model. This study provided an experimental basis for the clinical application of BB in AD therapy.
authors.affiliation: Key Laboratory of Anti-Inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Yin
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Ren
authors.forename: Wangyang
authors.initials: W
authors.lastname: Wu
authors.forename: Yuchan
authors.initials: Y
authors.lastname: Wang
authors.forename: Mingcheng
authors.initials: M
authors.lastname: Cao
authors.forename: Zhengyi
authors.initials: Z
authors.lastname: Zhu
authors.forename: Mingming
authors.initials: M
authors.lastname: Wang
authors.forename: Weizu
authors.initials: W
authors.lastname: Li
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D003517:Cyclopentanes / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D005663:Furans / Q000494:pharmacology*; D046934:Ginkgolides / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D007859:Learning Disabilities / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning; D008569:Memory Disorders / Q000517:prevention & control*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D010446:Peptide Fragments / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D003517:Cyclopentanes; D005663:Furans; D046934:Ginkgolides; D010446:Peptide Fragments; D014409:Tumor Necrosis Factor-alpha; C074636:amyloid beta-protein (25-35); D008315:Malondialdehyde; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D005978:Glutathione; C073710:bilobalide