title: Molecular mechanisms of actions of formulations of the thyroid hormone analogue, tetrac, on the inflammatory response.
abstract: BACKGROUND
  Tetraiodothyroacetic acid (tetrac) and its nanoparticulate formulation (Nanotetrac) act at a cell surface receptor to block angiogenesis and tumor cell proliferation.
  
  
  OBJECTIVE
  The complex anti-angiogenic properties of tetrac and Nanotetrac caused us to search in the literature and in certain of our unpublished mRNA experiments for evidence that these agents affect the early inflammatory response, perhaps through actions on specific cytokines and chemokines.
  
  
  CONCLUSIONS
  Tetrac and Nanotetrac inhibit expression in tumor cells of cytokine genes, e.g., specific interleukins, and chemokine genes, such as fractalkine (CX3CL1), and chemokine receptor genes (CX3CR1) that have been identified as high priority targets in the development of inflammation-suppressant drugs. The possibility is also examined that tetrac formulations have an effect on the function of inflammatory cells.
authors.affiliation: Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York 12144, USA. pdavis.ordwayst@gmail.com
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Davis
authors.forename: Gennadi V
authors.initials: GV
authors.lastname: Glinsky
authors.forename: Hung-Yun
authors.initials: HY
authors.lastname: Lin
authors.forename: Sandra
authors.initials: S
authors.lastname: Incerpi
authors.forename: Faith B
authors.initials: FB
authors.lastname: Davis
authors.forename: Shaker A
authors.initials: SA
authors.lastname: Mousa
authors.forename: Heng Yuan
authors.initials: HY
authors.lastname: Tang
authors.forename: Aleck
authors.initials: A
authors.lastname: Hercbergs
authors.forename: Mary K
authors.initials: MK
authors.lastname: Luidens
mesh_terms: D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D007378:Interleukins / Q000096:biosynthesis; D053758:Nanoparticles / Q000008:administration & dosage / Q000627:therapeutic use; D011988:Receptors, Thyroid Hormone / Q000096:biosynthesis; D013974:Thyroxine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D016207:Cytokines; D007378:Interleukins; D011988:Receptors, Thyroid Hormone; C011126:tetraiodothyroacetic acid; D013974:Thyroxine