title: Oncological outcome and prognostic factors in malignant parotid tumours.
abstract: OBJECTIVE
  To evaluate the oncological outcome of malignant parotid tumours and identify the prognostic factors for survival.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  One hundred and forty-one patients with primary epithelial carcinoma of the parotid gland were examined. The overall survival (OS) and disease specific survival (DSS) rates were calculated. The DSS was evaluated according to different parameters.
  
  
  RESULTS
  The 5- and 10-year OS rates were 72.3% and 58.4%. The 5- and 10-year DSS rate was 75% and 71%, respectively. The univariate analysis showed that the pathological staging, clinical and pathological tumour and nodal status, surgical procedure and histological subtype significantly influenced the DSS (P ≤ 0.05). The 5- and 10-year loco-regional control rates were 82.1% and 78%. The multivariate analysis showed that the pathological nodal status and the pathological staging influenced the DSS. It further demonstrated that the clinical tumour status and the histological subtype were the most important preoperative prognostic factors.
  
  
  CONCLUSIONS
  The pathological nodal status, the pathological staging, the clinical tumour status and the histological subtype are the most important factors influencing survival in malignant parotid tumours.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy. Electronic address: mercante.giuseppe@gmail.com.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mercante
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Marchese
authors.affiliation: Biostatistics - Scientific Direction, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Diana
authors.initials: D
authors.lastname: Giannarelli
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.
authors.forename: Raul
authors.initials: R
authors.lastname: Pellini
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cristalli
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Manciocco
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Ruscito
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Pichi
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Marchesi
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Spriano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality* / Q000601:surgery; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D010307:Parotid Neoplasms / Q000401:mortality* / Q000601:surgery; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
keywords: Oncologic outcome; Parotid; Prognostic factor; Tumour