title: Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A.
abstract: Precocious puberty (PP) refers to the appearance of physical and hormonal signs of pubertal development at an abnormally early age. Urinary steroid signatures obtained from 42 patients with central PP and 40 patients with peripheral PP were assessed to compare metabolic changes. Levels of androgens such as testosterone, androstenedione, androstenediol, 16α-hydroxy-dehydroepiandrosterone, and 5α-androstenedione tended to be high in both PP groups, and the level of 17β-estradiol was higher in the central-PP group (P<0.01) than in the peripheral-PP and 32 age-matched healthy girls. Altered steroid metabolism was also associated with urinary BPA levels, and levels of testosterone, 17β-estradiol, and pregnenolone were significantly increased among individuals with high BPA levels. In particular, a correlation was observed between estrogen metabolism and BPA levels irrespective of the type of PP. These findings suggest that in girls, BPA exposure causes metabolic changes in steroidogenesis, but not the early onset of PP.
authors.affiliation: Future Convergence Research Division, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea; Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea.
authors.forename: Su Hyeon
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Future Convergence Research Division, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea; Department of Basic Pharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Se Mi
authors.initials: SM
authors.lastname: Kang
authors.affiliation: Future Convergence Research Division, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea.
authors.forename: Man Ho
authors.initials: MH
authors.lastname: Choi
authors.affiliation: Future Convergence Research Division, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea.
authors.forename: Jeongae
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, Sanggye Paik Hospital, Seoul 139-707, Republic of Korea.
authors.forename: Mi Jung
authors.initials: MJ
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Sanggye Paik Hospital, Seoul 139-707, Republic of Korea.
authors.forename: Shin Hye
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea.
authors.forename: Won-Yong
authors.initials: WY
authors.lastname: Lee
authors.affiliation: Department of Basic Pharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.affiliation: Future Convergence Research Division, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea. Electronic address: bcc0319@kist.re.kr.
authors.forename: Bong Chul
authors.initials: BC
authors.lastname: Chung
mesh_terms: D001559:Benzhydryl Compounds / Q000652:urine*; D002648:Child; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000652:urine*; D004968:Estrogens, Non-Steroidal / Q000652:urine*; D005260:Female; D006801:Humans; D010636:Phenols / Q000652:urine*; D011629:Puberty, Precocious / Q000652:urine*; D013256:Steroids / Q000652:urine*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D013256:Steroids; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Gas chromatography–mass spectrometry; Metabolite profiling; Precocious puberty; Steroids