title: Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats.
abstract: The present study was carried out to assess the safety of standardized Panchakola Avaleha on albino rats (Wistar strain). Animals were administered three doses of Panchakola Avaleha by oral routes, viz. higher (500 mg/kg/day), middle (250 mg/kg/day), and therapeutic dose (50 mg/ kg/ day) for 28 consecutive days. Effects of the test drug on hematological, biochemical, and histopathologic parameters were evaluated. This study revealed normal behavior, no mortality, and no significant changes in hematological, biochemical, and histopathological examinations.
authors.affiliation: Senior Research Fellow, National Research Institute of Ayurvedic Drug Development, Central Council for Research in Ayurvedic Sciences, Department of AYUSH, Ministry of Health and Family Welfare, Government of India, Kolkata, West Bengal, India.
authors.forename: Rajendra Kumar
authors.initials: RK
authors.lastname: Singh
authors.forename: Rita
authors.initials: R
authors.lastname: Banerjee
authors.forename: Sachhidananda
authors.initials: S
authors.lastname: Upadhyay
authors.forename: Achintya
authors.initials: A
authors.lastname: Mitra
authors.forename: Jayram
authors.initials: J
authors.lastname: Hazra
keywords: Panchakola Avaleha; Wistar rats; toxicity study
references.citation: Ayu. 2011 Jan;32(1):70-5
references.pmid: 22131761
references.citation: Clin Chim Acta. 1976 Jul 15;70(2):F19-29
references.pmid: 954207