title: Impact of copolymer ratio on drug distribution in styrene-isobutylene-styrene block copolymers.
abstract: Drug-polymer composite coatings, composed of styrene-isobutylene-styrene (SIBS) tri-block copolymers, are frequently used in controlled drug release biomedical device applications. In this work, we used atomic force microscopy to characterize the effects of different drug loadings and polymer chemistries (i.e., block copolymer ratio) on the variation of surface structures and compositions of SIBS-tetracycline (SIBS-TC) cast composites including tetracycline (TC) drug amount, drug phase size distribution, and drug and polymer phase morphologies. We tested the structural variations by fabricating and characterizing two types of composite specimens, that is, SIBS15 and SIBS30, composed of 15 and 30 Wt % of polystyrene (PS), respectively. The differences in the distribution of TC drug, PS, and polyisobutylene (PIB) polymer phase structures observed in SIBS15 and SIBS30 resulted in more drug at the surface of SIBS30 compared to SIBS15. To support the experimental findings, we have determined the Hildebrand solubility parameter of TC using molecular dynamics (MD) computation and compared it to the polymer components, PS and PIB. The MD results show that the solubility parameter of TC is much closer to that of PS than PIB, which demonstrates a higher thermodynamic stability of TC-PS mixtures.
authors.affiliation: Division of Chemistry and Materials Science, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland 20993.
authors.forename: Martin K
authors.initials: MK
authors.lastname: McDermott
authors.forename: Chang-Soo
authors.initials: CS
authors.lastname: Kim
authors.forename: David M
authors.initials: DM
authors.lastname: Saylor
authors.forename: Dinesh V
authors.initials: DV
authors.lastname: Patwardhan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D016503:Drug Delivery Systems; D013343:Styrenes / Q000737:chemistry*; D013752:Tetracycline / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D013343:Styrenes; C500040:poly(styrene-b-isobutylene-b-styrene); D013752:Tetracycline
keywords: atomic force microscopy; block copolymer; controlled release; molecular modeling; stents