title: Mirror visual feedback can induce motor learning in patients with callosal disconnection.
abstract: Mirror therapy using mirror visual feedback (MVF) has been applied to the stroke rehabilitation of hemiparesis. One possible mechanism of mirror therapy is the functional interhemispheric connectivity between sensorimotor areas via corpus callosum. To test this hypothesis, we investigated the MVF-induced motor learning in 2 patients with callosal disconnection. Callosal connection in patients was evaluated by clinical measures and the interhemispheric inhibition (IHI) using transcranial magnetic stimulation. Both patients suffered from somatosensory cognitive disconnection, and one showed the loss of IHI. Motor training with MVF significantly improved the motor behavior of both patients. Extending our previous study, the results of callosal patients suggested that the visual feedback through a mirror might play the crucial important role for the improvement of motor performance, rather than interhemispheric interaction via corpus callosum.
authors.affiliation: Kobe University Graduate School of Health Science, Hyogo, 654-0142, Japan.
authors.forename: Ippei
authors.initials: I
authors.lastname: Nojima
authors.forename: Tatsuhide
authors.initials: T
authors.lastname: Oga
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Toshio
authors.initials: T
authors.lastname: Kawamata
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mima
mesh_terms: D000368:Aged; D001927:Brain Diseases / Q000503:physiopathology / Q000534:rehabilitation*; D001931:Brain Mapping; D003337:Corpus Callosum / Q000503:physiopathology*; D056228:Feedback, Sensory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods
references.citation: Brain. 1978 Sep;101(3):447-60
references.pmid: 101279
references.citation: Neuropsychologia. 1985;23(4):497-514
references.pmid: 4033904
references.citation: Neuropsychologia. 1984;22(5):601-11
references.pmid: 6504300
references.citation: Proc Biol Sci. 1996 Apr 22;263(1369):377-86
references.pmid: 8637922
references.citation: Exp Brain Res. 2005 May;163(1):118-22
references.pmid: 15754176
references.citation: Neurology. 1982 Jun;32(6):645-50
references.pmid: 7201094
references.citation: Annu Rev Neurosci. 2004;27:169-92
references.pmid: 15217330
references.citation: Neuropsychologia. 1971 Mar;9(1):97-113
references.pmid: 5146491
references.citation: J Neurosci. 2012 Jan 25;32(4):1293-300
references.pmid: 22279214
references.citation: Neuroreport. 2001 May 25;12(7):1469-72
references.pmid: 11388432
references.citation: NeuroRehabilitation. 2008;23(3):245-52
references.pmid: 18560141
references.citation: Arch Phys Med Rehabil. 2008 Mar;89(3):393-8
references.pmid: 18295613
references.citation: J Physiol. 2009 Oct 1;587(Pt 19):4629-44
references.pmid: 19687124
references.citation: Pain. 2004 Mar;108(1-2):192-8
references.pmid: 15109523
references.citation: Brain. 1989 Aug;112 ( Pt 4):1019-37
references.pmid: 2775991
references.citation: J Physiol. 1992;453:525-46
references.pmid: 1464843
references.citation: J Physiol. 1998 Jul 1;510 ( Pt 1):249-59
references.pmid: 9625881
references.citation: Arch Phys Med Rehabil. 2003 Jul;84(7):1090-2
references.pmid: 12881842
references.citation: Soc Neurosci. 2008;3(3-4):261-75
references.pmid: 18979380
references.citation: Lancet. 1999 Jun 12;353(9169):2035-6
references.pmid: 10376620
references.citation: J Neurol Neurosurg Psychiatry. 1979 Feb;42(2):134-42
references.pmid: 422960
references.citation: Cortex. 1988 Dec;24(4):601-4
references.pmid: 3219875
references.citation: Neurorehabil Neural Repair. 2000;14(1):73-6
references.pmid: 11228952
references.citation: Arch Phys Med Rehabil. 2007 May;88(5):555-9
references.pmid: 17466722
references.citation: J Neurosurg Sci. 1997 Mar;41(1):59-66
references.pmid: 9273860
references.citation: Cortex. 1991 Jun;27(2):327-31
references.pmid: 1879161
references.citation: Brain. 1991 Oct;114 ( Pt 5):2333-51
references.pmid: 1933248
references.citation: Arch Phys Med Rehabil. 2009 Apr;90(4):675-81
references.pmid: 19345786
references.citation: Neurorehabil Neural Repair. 2009 Mar-Apr;23(3):209-17
references.pmid: 19074686
references.citation: Eur J Neurosci. 2001 Jan;13(2):400-4
references.pmid: 11168545
references.citation: J Neurophysiol. 2012 Nov;108(10):2857-61
references.pmid: 22972955
references.citation: Neurorehabil Neural Repair. 2012 Jun;26(5):484-96
references.pmid: 22247501
references.citation: Scand J Plast Reconstr Surg Hand Surg. 2005;39(2):104-8
references.pmid: 16019738
references.citation: J Neurol Neurosurg Psychiatry. 2001 Oct;71(4):462-71
references.pmid: 11561028