title: Genetic polymorphisms of the tumor necrosis factor and lymphotoxin alpha in type 2 diabetes.
abstract: OBJECTIVE
  To investigate the frequency of the single-base change polymorphic variants identified in tumor necrosis factor (TNF) gene (-308 G/A) and lymphotoxin alpha (LTA) (+252 G/A) in patients with type 2 diabetes (T2D).
  
  
  METHODS
  A prospective study in a Mexican-mestizo population of 51 patients with T2D and 48 healthy subjects was carried out. We took a peripheral blood sample from each individual for identification of the polymorphic genotypes by polymerase chain reaction.
  
  
  RESULTS
  The genotype distribution in T2D was: TNF alpha homozygous 0%; TNFG/A heterozygous 20%; TNFG homozygous 80%.
  
  
  CONCLUSIONS
  In regards to the TNF -308 G/A genotype, we found a significant difference (p = 0.012) with a bigger frequency in the group of patients. The health controls showed a higher frequency of TNF -308 G/G genotype (p = 0.034).
authors.affiliation: Unidad de Investigación Médica en Immunología e Infectología, Hospital de Infectología, Centro Médico Nacional La Raza (CMNR), Instituto Mexican del Seguro Social (IMSS), Mexico City, Mexico. gelorriaga@webtelmex.net.mx
authors.forename: Guadalupe
authors.initials: G
authors.lastname: García-Elorriaga
authors.forename: Melby
authors.initials: M
authors.lastname: Mendoza-Aguilar
authors.forename: Guillermo
authors.initials: G
authors.lastname: del Rey-Pineda
authors.forename: César
authors.initials: C
authors.lastname: González-Bonilla
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
chemical_list: D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha