title: Association between cerebrospinal fluid S100B protein and neuronal damage in patients with central nervous system infections.
abstract: OBJECTIVE
  S100B protein is widely used as a measure of glial activity or damage in several brain conditions. Central nervous system (CNS) infections can cause neurological sequelae because of parenchyma invasion. It is difficult to predict further neuronal damage in the CNS infection. The present study is aimed to evaluate the role of the cerebrospinal fluid (CSF) S100B protein as an indicator of neuronal damage in CNS infection.
  
  
  METHODS
  We measured the concentration of CSF S100B protein in 62 patients with a CNS infection using an Enzyme-Linked Immunosorbent Assay. The patients with CNS infections were classified as having no neuronal damage (CNS-N) or as having neuronal damage (CNS+N) according to the presence of neurological change or structural lesions on brain MRI.
  
  
  RESULTS
  The CSF S100B protein level of the CNS+N group (n=22, 0.235 μg/L, 0.10-2.18) was significantly higher than that of the CNS-N group (n=40, 0.087 μg/L, 0.06-0.12) and control group (n=40, 0.109 μg/L, 0.07-0.14, p<0.01). Using an arbitrary cut off value, S100B-positive CSF was detected in 2.5% of the CNS-N group and in 50% of the CNS+N group (p<0.05).
  
  
  CONCLUSIONS
  These findings suggest that increased S100B protein levels in the CSF may be associated with the neuronal damage following CNS infections.
authors.affiliation: Department of Neurology, The Catholic University of Korea College of Medicine, Uijeongbu St. Mary's Hospital, 271 Cheonbo-ro, Uijeongbu 480-717, Korea.
authors.forename: Jeong-Wook
authors.initials: JW
authors.lastname: Park
authors.forename: Gyoung Im
authors.initials: GI
authors.lastname: Suh
authors.forename: Hae-Eun
authors.initials: HE
authors.lastname: Shin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D002494:Central Nervous System Infections / Q000134:cerebrospinal fluid / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064568:S100 Calcium Binding Protein beta Subunit / Q000134:cerebrospinal fluid*
chemical_list: D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human
keywords: CNS infections; S100B protein; neuronal damage
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