title: Flavonoids from the capitula of Eriocaulon australe.
abstract: A flavan, eriocaulin A (1), and three flavone acyl glucosides, eriocaulosides A-C (2-4) were isolated from the capitula of Eriocaulon australe R. Br. (Eriocaulaceae), a Chinese medicine and an herb for health care beverages, together with seven known flavones and three isoflavones (5-14). The new flavonoids were elucidated as (2S)-3',4'-methylenedioxy-5-methoxy-7-hydroxyflavan (1), hispidulin 7-O-β-D-(6-O-cinnamoyl)glucopyranoside (2), jaceosidin 7-O-β-D-(6-O-p-coumaroyl)glucopyranoside (3), jaceosidin 7-O-β-D-(6-O-p-hydroxybenzoyl)glucopyranoside (4) based on their spectroscopic data. All the 14 flavonoids were obtained from this species for the first time. The in vitro cytotoxicity of compounds 1-14 against human lung adenocarcinoma A549, human breast adenocarcinoma MCF-7, and human cervical carcinoma HeLa cell lines was evaluated using the MTT colourimetric assay. Compounds 1, 7, and 9 were cytotoxic to A549, compounds 1, 2, 7, 9, 12, and 14 to MCF-7, and compounds 7, 9, and 14 to HeLa cells, with IC50 values ranging from 7.17 to 29.57 μg/ml, while the others were inactive (IC50>50 μg/ml).
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, China.
authors.forename: Qiaolin
authors.initials: Q
authors.lastname: Xu
authors.forename: Haihui
authors.initials: H
authors.lastname: Xie
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D039262:Eriocaulaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D035264:Flowers / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D005419:Flavonoids; D010936:Plant Extracts