title: Ultra-protective tidal volume: how low should we go?
abstract: Applying tidal volumes of less than 6 mL/kg might improve lung protection in patients with acute respiratory distress syndrome. In a recent article, Retamal and colleagues showed that such a reduction is feasible with conventional mechanical ventilation and leads to less tidal recruitment and overdistension without causing carbon dioxide retention or auto-positive end-expiratory pressure. However, whether the compensatory increase in the respiratory rate blunts the lung protection remains unestablished.
authors.forename: Eduardo L V
authors.initials: EL
authors.lastname: Costa
authors.forename: Marcelo B P
authors.initials: MB
authors.lastname: Amato
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000175:diagnosis* / Q000628:therapy*; D013990:Tidal Volume / Q000502:physiology*
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