title: Chemoprevention of gastrointestinal cancer: the reality and the dream.
abstract: Despite substantial progress in screening, early diagnosis, and the development of noninvasive technology, gastrointestinal (GI) cancer remains a major cause of cancer-associated mortality. Chemoprevention is thought to be a realistic approach for reducing the global burden of GI cancer, and efforts have been made to search for chemopreventive agents that suppress acid reflux, GI inflammation and the eradication of Helicobacter pylori. Thus, proton pump inhibitors, statins, monoclonal antibodies targeting tumor necrosis factor-alpha, and nonsteroidal anti-inflammatory agents have been investigated for their potential to prevent GI cancer. Besides the development of these synthetic agents, a wide variety of the natural products present in a plant-based diet, which are commonly called phytoceuticals, have also sparked hope for the chemoprevention of GI cancer. To perform successful searches of chemopreventive agents for GI cancer, it is of the utmost importance to understand the factors contributing to GI carcinogenesis. Emerging evidence has highlighted the role of chronic inflammation in inducing genomic instability and telomere shortening and affecting polyamine metabolism and DNA repair, which may help in the search for new chemopreventive agents for GI cancer.
authors.affiliation: Keimyung University College of Pharmacy, Daegu, Korea.
authors.forename: Kyung-Soo
authors.initials: KS
authors.lastname: Chun
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Sooyeon
authors.initials: S
authors.lastname: Lee
authors.forename: Ki Baik
authors.initials: KB
authors.lastname: Hahm
keywords: Chemoprevention; Gastrointestinal neoplasms; Molecular target; Phytoceuticals
references.citation: Mol Nutr Food Res. 2011 Feb;55(2):259-67
references.pmid: 20848615
references.citation: Pharm Res. 2011 Apr;28(4):827-38
references.pmid: 21161336
references.citation: Carcinogenesis. 2006 Jun;27(6):1222-31
references.pmid: 16344271
references.citation: Cancer Prev Res (Phila). 2011 May;4(5):655-65
references.pmid: 21543343
references.citation: Cancer Lett. 2007 Oct 8;255(2):170-81
references.pmid: 17448598
references.citation: PLoS One. 2012;7(2):e30590
references.pmid: 22363450
references.citation: Nat Med. 2007 Apr;13(4):404-6
references.pmid: 17415370
references.citation: J Surg Oncol. 2005 Dec 1;92(3):151-9
references.pmid: 16299786
references.citation: J Biomed Biotechnol. 2012;2012:915380
references.pmid: 22690125
references.citation: J Neurosci. 2006 Apr 26;26(17):4672-80
references.pmid: 16641248
references.citation: Med J Aust. 2004 Apr 19;180(8):387-91
references.pmid: 15089728
references.citation: Invest New Drugs. 2001;19(1):81-3
references.pmid: 11291836
references.citation: Best Pract Res Clin Gastroenterol. 2011 Aug;25(4-5):461-72
references.pmid: 22122763
references.citation: Food Funct. 2011 Feb;2(2):101-10
references.pmid: 21779554
references.citation: PLoS One. 2011;6(9):e25166
references.pmid: 21980390
references.citation: Nutrition. 2003 Oct;19(10):837-42
references.pmid: 14559317
references.citation: Cancer Res. 2009 Aug 15;69(16):6423-9
references.pmid: 19638594
references.citation: Genes Chromosomes Cancer. 2003 Jun;37(2):201-6
references.pmid: 12696069
references.citation: Gut. 2006 Nov;55(11):1538-44
references.pmid: 16785284
references.citation: Cancer Res. 1966 Jul;26(7):1520-6
references.pmid: 5330111
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3103-9
references.pmid: 19861514
references.citation: J Korean Med Sci. 2001 Dec;16 Suppl:S81-6
references.pmid: 11748382
references.citation: Nutr Cancer. 2009;61(6):816-26
references.pmid: 20155622
references.citation: J Gastroenterol. 2011 Jan;46 Suppl 1:6-10
references.pmid: 20878190
references.citation: Clin Exp Pharmacol Physiol. 2012 Mar;39(3):227-32
references.pmid: 22211760
references.citation: N Engl J Med. 2001 Mar 1;344(9):632-6
references.pmid: 11228277
references.citation: Cancer Res. 2008 Jan 15;68(2):553-60
references.pmid: 18199552
references.citation: Gastroenterol Clin North Am. 1996 Dec;25(4):773-91
references.pmid: 8960892
references.citation: J Clin Invest. 2003 Dec;112(12):1887-94
references.pmid: 14679184
references.citation: Nutr Cancer. 2012;64(2):173-97
references.pmid: 22149093
references.citation: Adv Immunol. 2011;111:109-41
references.pmid: 21970953
references.citation: Biochem Pharmacol. 2003 Apr 1;65(7):1053-60
references.pmid: 12663041
references.citation: Cancer Res. 2004 Dec 1;64(23):8521-5
references.pmid: 15574757
references.citation: Carcinogenesis. 2011 Jun;32(6):897-903
references.pmid: 21421544
references.citation: Front Biosci (Elite Ed). 2011 Jun 01;3:1509-23
references.pmid: 21622155
references.citation: Oncology. 2006;71(1-2):124-30
references.pmid: 17347588
references.citation: Gut. 2010 Feb;59(2):156-63
references.pmid: 19651631
references.citation: Carcinogenesis. 2008 Jan;29(1):113-9
references.pmid: 17893236
references.citation: Biochem Soc Trans. 2007 Apr;35(Pt 2):300-4
references.pmid: 17371265
references.citation: Dig Dis Sci. 2005 Jul;50(7):1218-27
references.pmid: 16047463
references.citation: Clin Cancer Res. 2004 Dec 15;10(24):8687-96
references.pmid: 15623654
references.citation: Carcinogenesis. 1991 Sep;12(9):1619-25
references.pmid: 1909938
references.citation: J Natl Cancer Inst. 1978 Jul;61(1):49-52
references.pmid: 276637
references.citation: CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
references.pmid: 19474385
references.citation: Cancer Res. 1995 Oct 1;55(19):4264-7
references.pmid: 7671233
references.citation: Cancer Res. 2010 Oct 1;70(19):7392-9
references.pmid: 20841478
references.citation: Cancer Lett. 2008 Oct 8;269(2):199-225
references.pmid: 18479807
references.citation: J Epidemiol. 2005 Jun;15 Suppl 2:S109-12
references.pmid: 16127221
references.citation: Nat Med. 2007 Apr;13(4):470-6
references.pmid: 17401375
references.citation: Carcinogenesis. 2009 Sep;30(9):1544-52
references.pmid: 19578043
references.citation: J Med Food. 2004 Summer;7(2):117-21
references.pmid: 15298755
references.citation: Anticancer Res. 2010 Feb;30(2):319-25
references.pmid: 20332435
references.citation: Br J Nutr. 2012 Nov 14;108(9):1623-32
references.pmid: 22251620
references.citation: Z Gastroenterol. 2000 Jul;38(7):553-4, 556-8
references.pmid: 10965551
references.citation: Eur J Cancer Prev. 2010 Sep;19(5):352-4
references.pmid: 20502343
references.citation: Lancet Oncol. 2005 Dec;6(12):945-52
references.pmid: 16321762
references.citation: Nat Rev Cancer. 2003 Oct;3(10):768-80
references.pmid: 14570043
references.citation: Int J Oncol. 2012 Apr;40(4):1020-8
references.pmid: 22218562
references.citation: Mol Carcinog. 2008 Aug;47(8):638-46
references.pmid: 18300266
references.citation: Cancer Prev Res (Phila). 2008 Jun;1(1):32-8
references.pmid: 18841250
references.citation: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references.pmid: 21296855
references.citation: Gut. 2009 Oct;58(10):1323-32
references.pmid: 19505880
references.citation: Toxicol Appl Pharmacol. 2007 Nov 1;224(3):337-49
references.pmid: 17475300
references.citation: Dig Dis Sci. 2007 Apr;52(4):973-82
references.pmid: 17333352
references.citation: Cancer Biol Ther. 2009 Jul;8(14):1360-8
references.pmid: 19448398
references.citation: Dig Dis Sci. 2011 May;56(5):1309-14
references.pmid: 21053077
references.citation: Br J Pharmacol. 2012 Jul;166(5):1724-37
references.pmid: 22300262
references.citation: Cancer Prev Res (Phila). 2011 Sep;4(9):1507-21
references.pmid: 21733838
references.citation: Pharmacol Res. 2012 Jun;65(6):584-91
references.pmid: 22465196
references.citation: Dig Dis Sci. 1998 Feb;43(2):235-40
references.pmid: 9512112
references.citation: J Natl Cancer Inst. 2008 Aug 20;100(16):1184-7
references.pmid: 18695138
references.citation: World J Gastroenterol. 2011 Dec 21;17(47):5197-202
references.pmid: 22215945
references.citation: Biochem Biophys Res Commun. 2009 Nov 20;389(3):527-30
references.pmid: 19744467
references.citation: Cancer Res. 2011 Mar 1;71(5):1669-79
references.pmid: 21363920
references.citation: Dig Dis Sci. 2010 Jun;55(6):1696-703
references.pmid: 19705280
references.citation: Cancer Prev Res (Phila). 2010 Aug;3(8):963-74
references.pmid: 20628001
references.citation: Oncol Rep. 2012 Jul;28(1):232-40
references.pmid: 22552693
references.citation: Carcinogenesis. 2003 Mar;24(3):353-62
references.pmid: 12663492
references.citation: Neoplasma. 2010;57(5):422-8
references.pmid: 20568896
references.citation: Cell Cycle. 2006 Jul;5(13):1443-7
references.pmid: 16855398
references.citation: Int J Mol Med. 2010 Nov;26(5):735-41
references.pmid: 20878096
references.citation: Nucleic Acids Res. 2008 Aug;36(13):4327-36
references.pmid: 18586825
references.citation: Int J Oncol. 2011 Mar;38(3):879-85
references.pmid: 21206971
references.citation: Lancet. 2012 Apr 28;379(9826):1591-601
references.pmid: 22440947
references.citation: Nat Clin Pract Oncol. 2005 Apr;2(4):202-10
references.pmid: 16264935
references.citation: World J Gastroenterol. 2006 Sep 21;12(35):5628-34
references.pmid: 17007014
references.citation: Adv Exp Med Biol. 2007;595:149-72
references.pmid: 17569209
references.citation: Mol Cancer Ther. 2009 Nov;8(11):3046-55
references.pmid: 19887546
references.citation: Antioxid Redox Signal. 2006 May-Jun;8(5-6):1003-10
references.pmid: 16771690
references.citation: Int J Oncol. 2002 Dec;21(6):1275-83
references.pmid: 12429978
references.citation: Scand J Gastroenterol Suppl. 2003;(239):15-23
references.pmid: 14743878
references.citation: Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8290-5
references.pmid: 10880565
references.citation: Cancer Sci. 2012 Jul;103(7):1201-6
references.pmid: 22469133
references.citation: Cancer Prev Res (Phila). 2009 Aug;2(8):751-8
references.pmid: 19622613
references.citation: Cancer Cell. 2011 Jun 14;19(6):728-39
references.pmid: 21665147
references.citation: Oncol Rep. 2011 Nov;26(5):1197-203
references.pmid: 21811763
references.citation: Pain. 2005 Sep;117(1-2):30-9
references.pmid: 16043293
references.citation: Front Biosci. 2007 Jan 01;12:2309-15
references.pmid: 17127241
references.citation: Cancer Res. 2005 Sep 1;65(17):8049-56
references.pmid: 16140980
references.citation: JAMA. 2005 Sep 14;294(10):1255-9
references.pmid: 16160134
references.citation: Antioxid Redox Signal. 2006 May-Jun;8(5-6):1033-45
references.pmid: 16771693
references.citation: Cancer Res. 1976 Jul;36(7 PT 2):2699-702
references.pmid: 1277177
references.citation: Gut. 1982 Jun;23(6):490-7
references.pmid: 7076024
references.citation: Aliment Pharmacol Ther. 2008 Feb 15;27(4):321-6
references.pmid: 18047565
references.citation: BMC Public Health. 2002 Sep 4;2:18
references.pmid: 12213184
references.citation: Cancer Res. 2005 Nov 15;65(22):10623-31
references.pmid: 16288056
references.citation: Food Chem Toxicol. 2010 Jan;48(1):390-5
references.pmid: 19861145
references.citation: Cancer Biother Radiopharm. 2012 Apr;27(3):204-9
references.pmid: 22283637
references.citation: Biochem Pharmacol. 2001 Nov 15;62(10):1423-32
references.pmid: 11709203
references.citation: Clin Cancer Res. 2001 Jul;7(7):1894-900
references.pmid: 11448902
references.citation: Cancer Prev Res (Phila). 2008 Sep;1(4):298-304
references.pmid: 19138973
references.citation: Apoptosis. 2006 Jun;11(6):993-1001
references.pmid: 16547588
references.citation: Nature. 2011 Mar 24;471(7339):S5-7
references.pmid: 21430719
references.citation: Phytomedicine. 2011 Jun 15;18(8-9):672-6
references.pmid: 21315571
references.citation: J Biol Chem. 2005 Dec 16;280(50):41487-93
references.pmid: 16219763
references.citation: Cell. 2012 Jan 20;148(1-2):349-61
references.pmid: 22265420
references.citation: Planta Med. 2010 Oct;76(15):1659-65
references.pmid: 20506079
references.citation: Anticancer Res. 2004 Sep-Oct;24(5A):2783-840
references.pmid: 15517885
references.citation: Helicobacter. 2009 Dec;14(6):588-95
references.pmid: 19889077
references.citation: Hepatology. 1999 Aug;30(2):408-12
references.pmid: 10421648
references.citation: Cancer Res. 2002 Apr 1;62(7):2092-7
references.pmid: 11929830
references.citation: Cancer Prev Res (Phila). 2010 Apr;3(4):549-59
references.pmid: 20332304
references.citation: World J Gastroenterol. 2005 Jan 14;11(2):280-4
references.pmid: 15633232
references.citation: Am J Physiol Gastrointest Liver Physiol. 2002 May;282(5):G809-16
references.pmid: 11960777
references.citation: World J Gastroenterol. 2011 May 14;17(18):2315-25
references.pmid: 21633597
references.citation: J Biol Chem. 2003 Oct 17;278(42):41482-90
references.pmid: 12902349
references.citation: Gut. 2012 Jan;61(1):135-49
references.pmid: 21490374
references.citation: J Immunol. 2002 May 1;168(9):4692-700
references.pmid: 11971019
references.citation: Nat Rev Cancer. 2003 Sep;3(9):676-84
references.pmid: 12951586
references.citation: Carcinogenesis. 2002 Sep;23(9):1531-6
references.pmid: 12189197
references.citation: Int J Cancer. 2006 Jun 15;118(12):3030-44
references.pmid: 16404738
references.citation: Int J Cancer. 2007 Feb 1;120(3):469-76
references.pmid: 17066440
references.citation: Am J Gastroenterol. 2011 Dec;106(12):2098-103
references.pmid: 21844922
references.citation: Cancer Res. 2008 Mar 15;68(6):1962-9
references.pmid: 18339878
references.citation: Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8
references.pmid: 16757216
references.citation: Cancer Prev Res (Phila). 2010 Oct;3(10):1314-33
references.pmid: 20736334
references.citation: Cancer Prev Res (Phila). 2011 Nov;4(11):1835-41
references.pmid: 21803981
references.citation: J Ginseng Res. 2012 Apr;36(2):135-45
references.pmid: 23717113
references.citation: Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G626-34
references.pmid: 11518674
references.citation: World J Gastroenterol. 2012 Jan 14;18(2):126-35
references.pmid: 22253518
references.citation: Proteome Sci. 2011 Aug 17;9(1):49
references.pmid: 21849056
references.citation: Cell. 2010 Sep 3;142(5):687-98
references.pmid: 20813258
references.citation: Nat Rev Clin Oncol. 2012 Apr 03;9(5):259-67
references.pmid: 22473097
references.citation: J Biol Chem. 2002 Oct 18;277(42):39867-72
references.pmid: 12181316
references.citation: Best Pract Res Clin Gastroenterol. 2011 Aug;25(4-5):623-30
references.pmid: 22122776
references.citation: Biosci Rep. 2011 Jun;31(3):185-97
references.pmid: 20815812
references.citation: Pancreatology. 2011;11(6):574-84
references.pmid: 22213040
references.citation: Shock. 1999 Feb;11(2):115-9
references.pmid: 10030798
references.citation: J Agric Food Chem. 2010 Sep 22;58(18):10016-9
references.pmid: 20718469
references.citation: Biol Chem. 2006 Apr;387(4):365-72
references.pmid: 16606333
references.citation: J Clin Invest. 2008 Jul;118(7):2516-25
references.pmid: 18521188
references.citation: BMC Cancer. 2011 Aug 18;11:360
references.pmid: 21851602
references.citation: Nature. 2004 Feb 5;427(6974):504
references.pmid: 14765186
references.citation: Clin Cancer Res. 2004 Oct 15;10(20):6847-54
references.pmid: 15501961
references.citation: Int J Cancer. 2011 Feb 15;128(4):951-61
references.pmid: 20473900
references.citation: Carcinogenesis. 1995 Sep;16(9):2045-50
references.pmid: 7554052
references.citation: Free Radic Biol Med. 2011 May 15;50(10):1324-35
references.pmid: 21277973
references.citation: Int J Mol Med. 1998 Aug;2(2):221-224
references.pmid: 9855692
references.citation: Aliment Pharmacol Ther. 2000 Feb;14(2):145-53
references.pmid: 10651654
references.citation: Biochem Pharmacol. 2008 Feb 15;75(4):787-809
references.pmid: 17900536