title: Synthesis and antimicrobial activity of novel benzo[f]coumarin compounds.
abstract: The acetyl benzo[f]coumarin condensed with phenyl hydrazine to afford the corresponding phenyl hydrazone which cyclized into the pyrazolyl benzocoumarin under Vilsmeier reaction conditions. The pyrazolylaIdehyde was used as starting material for synthesis of other heterocyclic compounds containing pyrazolylbenzocoumarin moiety. The ethyl benzo[f]coumarin carboxylate were subjected to react with other reagents to synthesize thiazolidinyl and oxadiazolyl derivatives attached to benzocoumarin system. Some of novel synthesized compounds showed highly antibacterial and antifungal activities.
authors.affiliation: Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt. remonch2003@yahoo.com
authors.forename: Remon M
authors.initials: RM
authors.lastname: Zaki
authors.forename: Yasser A
authors.initials: YA
authors.lastname: Elossaily
authors.forename: Adel M Kamal
authors.initials: AM
authors.lastname: El-Dean
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D006854:Hydrocortisone; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D003374:Coumarins; D006571:Heterocyclic Compounds; D011720:Pyrazoles; C030123:coumarin; D006854:Hydrocortisone