title: Recent patents on mesenchymal stem cell mediated therapy in inflammatory diseases.
abstract: Inflammation is the propitious response of vascular tissue to pathogens, damaged cells or irritants. Recent discoveries on the molecular and cellular basis of inflammation and allergy have markedly altered the understanding of these disorders. Although the conventional therapy used for the treatment of autoimmune and inflammatory diseases has improved the condition of patients but it has also placed them at the stake of enormous side effects. In recent times, the usage of Mesenchymal Stem Cell (MSC) therapy in the field of medical science has provided better alternative, concomitant treatment for these diseases as suggested by preclinical studies. Thus, in this review we have summarized the recent findings on MSCs as a therapeutic agent in treating inflammatory disorders using novel methods. This review also outlines the current state of knowledge on the biology of MSCs and their use as a suitable candidate for cell-based therapeutics. In addition, we focus on various patents, in which administration of MSC attenuates inflammation and injury thereby suggesting its integral role in host immune response, immunomodulation and anti-inflammation, which may in turn lead to novel patents in this field in the future.
authors.affiliation: Stem Cell Technology Laboratory, Centre for Scientific Research and Development, C.S.R.D., 4th Floor University building, People's University, Bhopal, M.P. 462037, India. meera.nair3@gmail.com
authors.forename: Meera
authors.initials: M
authors.lastname: Nair
authors.forename: Pooja
authors.initials: P
authors.lastname: Saxena
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D010330:Patents as Topic; D044968:Regenerative Medicine / Q000379:methods