title: [Complete hormonal and metabolic response after iodine-131 metaiodobenzylguanidine treatment in a patient diagnosed of malignant pheochromocytoma].
abstract: Radiolabeled metaiodobenzylguanidine is an analogue of norepinephrine used to localize tumors that express the neurohormone transporters, specifically those derived from the neural crest having a neuroendocrine origin. It is also used to treat non-surgical metastases derived from them. A review of the literature revealed symptomatic improvements associated to a decrease in hormone levels in a significant percentage of patients after (131)I-MIBG treatment. However, complete tumor remission has been described only in very few cases and hardly ever when bone metastases exist. We present a case of a patient diagnosed of malignant pheochromocytoma who achieved complete hormonal and metabolic response after (131)I-MIBG treatment (600 mCi) in spite of the presence of bone metastases.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario de Getafe, Getafe, Madrid, España. Electronic address: pilargarciaalonso@yahoo.es.
authors.forename: M P
authors.initials: MP
authors.lastname: García Alonso
authors.forename: M A
authors.initials: MA
authors.lastname: Balsa Bretón
authors.forename: C
authors.initials: C
authors.lastname: Paniagua Correa
authors.forename: L
authors.initials: L
authors.lastname: Castillejos Rodríguez
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez Pelayo
authors.forename: A
authors.initials: A
authors.lastname: Mendoza Paulini
authors.forename: A
authors.initials: A
authors.lastname: Ortega Valle
authors.forename: J
authors.initials: J
authors.lastname: Penín González
mesh_terms: D019797:3-Iodobenzylguanidine / Q000627:therapeutic use*; D000310:Adrenal Gland Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary; D006801:Humans; D008297:Male; D018377:Neurotransmitter Agents / Q000096:biosynthesis; D010673:Pheochromocytoma / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary; D012074:Remission Induction; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D018377:Neurotransmitter Agents; D019797:3-Iodobenzylguanidine
keywords: Feocromocitoma maligno; Malignant pheochromocytoma; Metaiodobenzylguanidine; Metayodobencilguanidina; Tratamiento; Treatment