title: Training health workers for magnesium sulfate use reduces case fatality from eclampsia: results from a multicenter trial.
abstract: OBJECTIVE
  To investigate the effectiveness of an intervention aimed at improving the case management of eclampsia.
  
  
  METHODS
  A multi-center intervention study.
  
  
  METHODS
  Six teaching hospitals in Nigeria.
  
  
  METHODS
  Clinical records of cases of eclampsia treated before and 1 year after the intervention.
  
  
  METHODS
  Doctors and midwives in selected hospitals were re-trained to manage eclampsia using magnesium sulfate according to the Pritchard protocol.
  
  
  METHODS
  Eclampsia case fatality rates, maternal and perinatal mortality rates before and after the intervention.
  
  
  RESULTS
  A total of 219 cases of eclampsia were managed over a 12-month period. There were seven maternal deaths. The post intervention case fatality rate of 3.2% was significantly less than the pre-intervention rate of 15.1% (p < 0.001). The overall maternal and perinatal mortality ratios and rates respectively in the hospitals declined from 1199.2 to 954 per 100,000 deliveries and 141.5 to 129.8 per 1000 births, respectively (p > 0.05).
  
  
  CONCLUSIONS
  An intervention to build the capacity of care-providers to use an evidence-based protocol for the treatment of eclampsia in Nigeria was successful in reducing associated case fatality rate. The increased and widespread use of such an intervention in maternity units might contribute to the reduction of maternal mortality in low-income countries.
authors.affiliation: Department of Obstetrics and Gynecology, University of Benin, Benin City, Nigeria. feokonofua@yahoo.co.uk
authors.forename: Friday E
authors.initials: FE
authors.lastname: Okonofua
authors.forename: Rosemary N
authors.initials: RN
authors.lastname: Ogu
authors.forename: Adetokunbo O
authors.initials: AO
authors.lastname: Fabamwo
authors.forename: Innocent O
authors.initials: IO
authors.lastname: Ujah
authors.forename: Calvin M
authors.initials: CM
authors.lastname: Chama
authors.forename: Eric I
authors.initials: EI
authors.lastname: Archibong
authors.forename: Hyacinth E
authors.initials: HE
authors.lastname: Onah
authors.forename: Hadiza S
authors.initials: HS
authors.lastname: Galadanci
authors.forename: James T
authors.initials: JT
authors.lastname: Akuse
mesh_terms: D000293:Adolescent; D000328:Adult; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D004461:Eclampsia / Q000188:drug therapy* / Q000401:mortality*; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008428:Maternal Mortality; D008505:Medical Staff, Hospital / Q000193:education*; D009549:Nigeria / Q000453:epidemiology; D009721:Nurse Midwives / Q000193:education*; D054238:Perinatal Mortality; D011247:Pregnancy; D015149:Tocolytic Agents / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D015149:Tocolytic Agents; D008278:Magnesium Sulfate