title: Ir(I)-catalyzed synthesis of N-substituted pyridones from 2-alkoxypyridines via C-O bond cleavage.
abstract: A cationic Ir(I) complex-catalyzed O-to-N-alkyl migration in 2-alkoxypyridines bearing a secondary alkyl group on the oxygen atom by C-O bond cleavage is described. The present transformation gave various N-alkylpyridones in moderate to good yields. The addition of sodium acetate played a key role in suppressing β-hydrogen elimination.
authors.affiliation: Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555, Japan.
authors.forename: Shiguang
authors.initials: S
authors.lastname: Pan
authors.forename: Naoto
authors.initials: N
authors.lastname: Ryu
authors.forename: Takanori
authors.initials: T
authors.lastname: Shibata
mesh_terms: D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011725:Pyridines; D011728:Pyridones; D007495:Iridium; D006859:Hydrogen