title: The estimation of neurotransmitter release probability in feedforward neuronal network based on adaptive synchronization.
abstract: In this paper, we proposed a new approach to estimate unknown parameters and topology of a neuronal network based on the adaptive synchronization control scheme. A virtual neuronal network is constructed as an observer to track the membrane potential of the corresponding neurons in the original network. When they achieve synchronization, the unknown parameters and topology of the original network are obtained. The method is applied to estimate the real-time status of the connection in the feedforward network and the neurotransmitter release probability of unreliable synapses is obtained by statistic computation. Numerical simulations are also performed to demonstrate the effectiveness of the proposed adaptive controller. The obtained results may have important implications in system identification in neural science.
authors.affiliation: School of Electrical and Automation Eng., Tianjin University, Tianjin 300072, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Xue
authors.forename: Jiang
authors.initials: J
authors.lastname: Wang
authors.forename: Chenhui
authors.initials: C
authors.lastname: Jia
authors.forename: Haitao
authors.initials: H
authors.lastname: Yu
authors.forename: Bin
authors.initials: B
authors.lastname: Deng
authors.forename: Xile
authors.initials: X
authors.lastname: Wei
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Che
mesh_terms: D000818:Animals; D003198:Computer Simulation; D005246:Feedback; D006801:Humans; D008564:Membrane Potentials; D008959:Models, Neurological; D015233:Models, Statistical; D009415:Nerve Net / Q000378:metabolism*; D016571:Neural Networks, Computer; D009474:Neurons / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009716:Numerical Analysis, Computer-Assisted; D010507:Periodicity; D013569:Synapses / Q000378:metabolism; D013997:Time Factors
chemical_list: D018377:Neurotransmitter Agents