title: Peritoneal mast cell stabilization potential of Pothos scandens L.
abstract: OBJECTIVE
  To investigate the peritoneal mast cell stabilization activity of Pothos scandens extracts.
  
  
  METHODS
  Pothos scandens L. (family- Araceae) aerial part was successively extracted with ethanol and aqueous to prepare extract of the plant. The extracts of P. scandens were evaluated for stabilization of mast cell in rat allergic models. The extract of P. scandens ethanolic, 50% aqueous ethanolic and aqueous (1, 10 and 100 μg/ml) was studied for peritoneal mast cell stabilization activity in rat mesenteric preparation induced by C 48/80.
  
  
  RESULTS
  Preliminary phytochemical analysis revealed the presence of carbohydrates, fixed oil, proteins, alkaloids, glycosides, flavonoids and phenolic compounds. The ethanolic, 50% aqueous ethanolic and aqueous extracts of P. scandens L. showed dose dependent increase in the number of intact cells when compare with C48/80 at the concentration of 10 and 100 μg/ml. It virtues further work towards the isolation of phytoconstituents from this plant.
  
  
  CONCLUSIONS
  This finding provides evidence that the P. scandens L. inhibits mast cell-derived immediate-type allergic reactions and mast cell degranulation. P. scandens has a potential as allergic anti- asthmatic agent.
authors.affiliation: Department of Pharmacognosy, JSS College of Pharmacy, Ootacamund, Tamil Nadu, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Gupta
authors.forename: B
authors.initials: B
authors.lastname: Duraiswamy
authors.forename: M N
authors.initials: MN
authors.lastname: Satishkumar
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D029064:Araceae / Q000737:chemistry*; D015550:Cell Degranulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006969:Hypersensitivity, Immediate / Q000517:prevention & control*; D008407:Mast Cells / Q000502:physiology*; D023421:Models, Animal; D010529:Peritoneal Cavity / Q000166:cytology*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats
chemical_list: D018926:Anti-Allergic Agents; D018927:Anti-Asthmatic Agents; D010936:Plant Extracts
keywords: Compound 48/80; Pothos scanden; ethanolic extract; mast cell
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