title: Creatinine-based equations to estimate glomerular filtration rate in Japanese children aged between 2 and 11 years old with chronic kidney disease.
abstract: BACKGROUND
  Renal inulin clearance is the gold standard for glomerular filtration rate (GFR), but is compromised by problems of collecting urine samples in children, especially those <6 years of age or with a bladder dysfunction. Therefore, we should utilize the serum creatinine (Cr)-based estimated GFR (eGFR), measuring serum Cr by enzymatic method. The updated Schwartz formulae were reported by enzymatic Cr instead of by the Jaffe method in American children aged 1-16 years old. We believe it would be better to determine serum Cr-based eGFR by the enzymatic method in Japanese children for evaluation of renal function.
  
  
  METHODS
  Serum Cr-based eGFR was determined by measuring inulin clearance and serum Cr level in 76 pediatric chronic kidney disease (CKD) patients (49 males and 27 females) aged 2-11 years with no underlying disease that would affect renal function.
  
  
  RESULTS
  We showed the inulin clearance by expression of the body length/serum Cr ratio in pediatric CKD patients, which resulted in the equation: [Formula: see text]. Additionally, we suggest the following serum Cr-based eGFR formula passing through the origin: [Formula: see text], because it is simple and easy to remember, thus making it clinically useful.
  
  
  CONCLUSIONS
  The new eGFR formula derived from body length and serum Cr level is applicable for clinical screening of renal function in Asian as well as Japanese children aged between 2 and 11 years old.
authors.affiliation: The Japanese Society for Pediatric Nephrology, the Committee of Measures for Pediatric CKD, Tokyo, Japan.
authors.forename: Takuhito
authors.initials: T
authors.lastname: Nagai
authors.forename: Osamu
authors.initials: O
authors.lastname: Uemura
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishikura
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hataya
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Gotoh
authors.forename: Naoya
authors.initials: N
authors.lastname: Fujita
authors.forename: Yuko
authors.initials: Y
authors.lastname: Akioka
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Kaneko
authors.forename: Masataka
authors.initials: M
authors.lastname: Honda
mesh_terms: D044466:Asian People; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007444:Inulin; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000097:blood*
chemical_list: D007444:Inulin; D003404:Creatinine
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