title: Long-term sequelae of childhood bacterial meningitis.
abstract: In most high-income countries, fewer children now acquire meningitis, and many of those who do will survive. Globally, however, meningitis still remains a significant cause of child morbidity and mortality. In this article, the authors review recent evidence on the morbidity faced by childhood survivors of bacterial meningitis. Outcomes vary by bacterial pathogen, with around a 20 % risk for severe sequelae (most commonly, neurocognitive) by all pathogenic causes. Pneumococcal, tuberculosis, and group B streptococcal meningitis lead to the highest rates of sequelae. Recent epidemiological shifts in the major pathogens causing meningitis, as well as varied regional settings between studies, limit generalizability of evidence in the literature, and better research using longitudinal data and case-control methodology is required, especially in low-income countries. However, the consistently high levels of complications described in the literature call for more widespread vaccination programs for prevention and a greater focus on potential complications by educators and health-care providers to support childhood survivors of bacterial meningitis and their families.
authors.affiliation: University College London Hospital, London, UK, l.hudson@ucl.ac.uk.
authors.forename: Lee D
authors.initials: LD
authors.lastname: Hudson
authors.forename: Russell M
authors.initials: RM
authors.lastname: Viner
authors.forename: Deborah
authors.initials: D
authors.lastname: Christie
references.citation: N Engl J Med. 2000 Jan 6;342(1):15-20
references.pmid: 10620644
references.citation: Acta Paediatr. 2013 Mar;102(3):e126-30
references.pmid: 23205710
references.citation: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD002244
references.pmid: 18254003
references.citation: Lancet. 2006 Jun 10;367(9526):1880-2
references.pmid: 16765742
references.citation: Brain Inj. 2011;25(13-14):1288-95
references.pmid: 21961570
references.citation: Pediatr Infect Dis J. 1995 Feb;14(2):112-7
references.pmid: 7746692
references.citation: Science. 2008 Jun 27;320(5884):1712
references.pmid: 18583589
references.citation: Intensive Care Med. 2007 May;33(5):798-806
references.pmid: 17377766
references.citation: Arch Dis Child. 2001 Nov;85(5):386-90
references.pmid: 11668100
references.citation: Lancet Infect Dis. 2010 May;10(5):317-28
references.pmid: 20417414
references.citation: Clin Infect Dis. 2009 Apr 15;48(8):1107-10
references.pmid: 19275501
references.citation: Pediatrics. 2012 Dec;130(6):e1433-40
references.pmid: 23184116
references.citation: N Engl J Med. 1988 Oct 13;319(15):964-71
references.pmid: 3047581
references.citation: BMC Infect Dis. 2012 Mar 31;12:79
references.pmid: 22462525
references.citation: Pediatrics. 2012 Jul;130(1):e8-15
references.pmid: 22689869
references.citation: Hippocampus. 1997;7(3):249-56
references.pmid: 9228523
references.citation: Pediatr Infect Dis J. 2008 Dec;27(12):1057-64
references.pmid: 18989238
references.citation: Childs Nerv Syst. 2009 Sep;25(9):1105-6; discussion 1107, 1109-10
references.pmid: 19247678
references.citation: Lancet. 1995 Dec 23-30;346(8991-8992):1675-80
references.pmid: 8551828
references.citation: Pediatrics. 2009 Mar;123(3):e502-9
references.pmid: 19254985
references.citation: Pediatrics. 2009;123(1):e1-8
references.pmid: 19367678
references.citation: FEMS Microbiol Rev. 2007 Jan;31(1):3-14
references.pmid: 17233633
references.citation: BMJ. 2010 Jun 28;340:c3209
references.pmid: 20584794
references.citation: Pediatr Crit Care Med. 2005 Jan;6(1):39-43
references.pmid: 15636657
references.citation: Dev Med Child Neurol. 2002 Aug;44(8):522-6
references.pmid: 12206617
references.citation: Arch Dis Child. 2012 Nov;97(11):993-8
references.pmid: 22984187
references.citation: N Engl J Med. 1991 May 30;324(22):1525-31
references.pmid: 2027357
references.citation: Pediatr Infect Dis J. 2010 Nov;29(11):1009-12
references.pmid: 20555292
references.citation: JAMA. 1999 Aug 18;282(7):677-86
references.pmid: 10517722
references.citation: Eur J Paediatr Neurol. 2013 Jan;17(1):24-8
references.pmid: 22789668
references.citation: BMJ. 2008 Jun 14;336(7657):1367-70
references.pmid: 18556318
references.citation: Curr Opin Neurol. 2010 Jun;23(3):312-8
references.pmid: 20442574
references.citation: Pediatr Infect Dis J. 2013 Feb;32(2):e54-61
references.pmid: 22914560
references.citation: Ir J Med Sci. 2011 Mar;180(1):47-50
references.pmid: 21072618
references.citation: Trop Med Int Health. 2006 Jun;11(6):773-80
references.pmid: 16771997
references.citation: Curr Infect Dis Rep. 2007 Jul;9(4):301-7
references.pmid: 17618550
references.citation: Vaccine. 2009 Jun 24;27 Suppl 2:B51-63
references.pmid: 19477562
references.citation: Acta Paediatr. 2009 Mar;98(3):543-7
references.pmid: 19046349