title: A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population.
abstract: The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population. Therefore, we selected three single nucleotide polymorphisms (SNPs) from these candidate genes and genotyped them using PCR-based restriction fragment length polymorphism analysis in 249 ACS patients and 240 non-ACS subjects, as were Han Chinese ancestry. The results showed that rs174556 in the FADS1 gene is found to be in allelic association (P = 0.003 ) and genotypic association (P = 0.036) with ACS. The frequencies of rs174556 minor allele (T) in case group were obviously higher than in control group. The trans-phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was associated with ACS (P = 0.031). And the results suggest that, for rs174556 C>T, the CT/TT genotypes were more likely to lead in ACS in subjects with hypertension after correction of all risk factors (OR = 4.236, 95% CI, 2.216-7.126). These findings suggest that the polymorphisms of rs174556 in the FADS1 gene are very likely to be associated with ACS in Chinese Han population, especially in subjects with hypertension.
authors.affiliation: Department of Cardiology, the Second Division of the First Hospital, Jilin University, 3302 JiLin Street, Changchun 130031, China.
authors.forename: Zikai
authors.initials: Z
authors.lastname: Song
authors.forename: Hongyan
authors.initials: H
authors.lastname: Cao
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000123:Acetyltransferases / Q000235:genetics*; D054058:Acute Coronary Syndrome / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China; D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases / Q000235:genetics*; D000081031:Fatty Acid Elongases; D005231:Fatty Acids, Unsaturated / Q000235:genetics / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; C000630967:ELOVL2 protein, human; D005231:Fatty Acids, Unsaturated; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human; C533241:FADS2 protein, human; D000123:Acetyltransferases; D000081031:Fatty Acid Elongases
references.citation: J Lipid Res. 2011 Feb;52(2):245-55
references.pmid: 21106902
references.citation: Nat Rev Cardiol. 2011 Mar;8(3):140-7
references.pmid: 21173793
references.citation: Biochim Biophys Acta. 1994 Aug 4;1213(3):277-88
references.pmid: 7914092
references.citation: PLoS Genet. 2009 Jan;5(1):e1000338
references.pmid: 19148276
references.citation: BMC Cardiovasc Disord. 2012 Feb 15;12:6
references.pmid: 22333273
references.citation: Am J Clin Nutr. 2007 Feb;85(2):554-60
references.pmid: 17284757
references.citation: Circulation. 2005 Nov 22;112(21):3232-8
references.pmid: 16301356
references.citation: PLoS One. 2012;7(5):e37780
references.pmid: 22629455
references.citation: Genomics. 2000 Jun 1;66(2):175-83
references.pmid: 10860662
references.citation: Am J Clin Nutr. 2011 Jan;93(1):211-9
references.pmid: 21106917
references.citation: J Nutr. 2008 Nov;138(11):2222-8
references.pmid: 18936223
references.citation: Circulation. 2001 Nov 27;104(22):2746-53
references.pmid: 11723030
references.citation: Lipids. 2008 Apr;43(4):289-99
references.pmid: 18320251
references.citation: Front Genet. 2012 May 03;3:72
references.pmid: 22563332
references.citation: Crit Care Med. 2011 Oct;39(10):2346-53
references.pmid: 21602671
references.citation: Nat Genet. 2010 Feb;42(2):137-41
references.pmid: 20037589
references.citation: Circulation. 1979 Mar;59(3):607-9
references.pmid: 761341
references.citation: Am J Clin Nutr. 2011 Feb;93(2):382-91
references.pmid: 21147856
references.citation: Prostaglandins Leukot Essent Fatty Acids. 2007 May;76(5):251-68
references.pmid: 17466497
references.citation: J Biol Chem. 1999 Jan 1;274(1):471-7
references.pmid: 9867867
references.citation: Am J Clin Nutr. 2010 May;91(5):1368-76
references.pmid: 20335541
references.citation: Biochim Biophys Acta. 2000 Jul 19;1486(2-3):219-31
references.pmid: 10903473
references.citation: Matern Child Nutr. 2011 Apr;7 Suppl 2:27-40
references.pmid: 21366865
references.citation: Atherosclerosis. 2011 Jan;214(1):94-100
references.pmid: 21040914
references.citation: J Lipid Res. 2010 Jan;51(1):182-91
references.pmid: 19546342
references.citation: Hum Mol Genet. 2006 Jun 1;15(11):1745-56
references.pmid: 16670158
references.citation: PLoS Genet. 2011 Jul;7(7):e1002193
references.pmid: 21829377
references.citation: Prostaglandins Leukot Essent Fatty Acids. 2011 Dec;85(6):329-33
references.pmid: 21917437
references.citation: Biochim Biophys Acta. 2006 Jan;1762(1):17-28
references.pmid: 16297602
references.citation: Circulation. 2007 Apr 10;115(14):1858-65
references.pmid: 17389261
references.citation: BMC Genet. 2011 May 20;12:50
references.pmid: 21599946
references.citation: Annu Rev Nutr. 2004;24:345-76
references.pmid: 15189125
references.citation: Biochim Biophys Acta. 1993 Oct 13;1170(2):137-42
references.pmid: 8399337
references.citation: Am J Clin Nutr. 2008 Oct;88(4):941-9
references.pmid: 18842780
references.citation: Br J Nutr. 2009 Jan;101(1):20-6
references.pmid: 18479586
references.citation: Lancet. 2006 May 27;367(9524):1747-57
references.pmid: 16731270
references.citation: Br J Nutr. 2010 Sep;104(6):788-96
references.pmid: 20522273
references.citation: Nutr Rev. 2010 May;68(5):280-9
references.pmid: 20500789