title: Treatment of breast cancer brain metastases.
abstract: Breast cancer represents the second most frequent cause of brain metastases. Treatment planning should consider several tumor and patient factors to estimate prognosis based on the Karnofsky Performance Status (KPS), age, extent of extra-cerebral disease as well as genetic subtype. When systemic disease is under control patients with up to three metastases qualify for local therapy, such as surgical excision or stereotactic radiotherapy. After the local treatment the addition of whole brain radiation therapy may be postponed until disease progression in the brain is observed and overall survival will not be compromised. Asymptomatic brain metastases may be first approached with a systemic treatment to which the primary tumor is considered to be sensitive.
authors.affiliation: Department of Oncology, University Hospital, Raemistrasse 100, 8091 Zürich, Switzerland.
authors.forename: Silvia
authors.initials: S
authors.lastname: Hofer
authors.forename: Bernhard C
authors.initials: BC
authors.lastname: Pestalozzi
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy*; D001943:Breast Neoplasms / Q000473:pathology*; D006801:Humans; D011379:Prognosis
keywords: Brain metastasis; Breast cancer; Genetic subtype; Local treatment; Prognosis; Systemic treatment