title: Six new cyclic peptides from the roots of Gypsophila oldhamiana.
abstract: Six new cyclic peptides, gypsophin A-F (1-6), were isolated from Gypsophila oldhamiana. Their structures were elucidated by extensive NMR and chemical degradation. Compound 3 exhibited moderate activity of antiplatelet aggregation in vitro.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Luo
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Yang
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Wang
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D029748:Caryophyllaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D045325:HCT116 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits
chemical_list: D010456:Peptides, Cyclic; D010975:Platelet Aggregation Inhibitors