title: [Mechanisms of development of thromboembolic complications in patients with atrial fibrillation].
abstract: Thomboembolism is the most threatening complication in patients with atrial fibrillation. Main source of embolism is the left atrial thrombosis. Mechanisms of development of thromboembolic complications in patients with arrhythmias are far from being deciphered. In this review we discuss possible mechanisms of formation of intracardiac thrombus - abnormalities of functioning of the hemostasis system, endothelial dysfunction, inflammatory reactions, fibrosis of the left atrial wall, genetic traits.
authors.affiliation: Educational Scientific Medical Centre of the General Management Department of the President of RF; ul. Marshala Timoshenko 21, 121359 Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Zotova
authors.forename: D A
authors.initials: DA
authors.lastname: Zateĭshchikov
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
mesh_terms: D001281:Atrial Fibrillation / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D017548:Echocardiography, Transesophageal / Q000379:methods; D004727:Endothelium / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D006325:Heart Atria / Q000503:physiopathology; D006439:Hemodynamics; D006487:Hemostasis / Q000235:genetics; D006801:Humans; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000503:physiopathology