title: Inflammation and Gliomagenesis: Bi-Directional Communication at Early and Late Stages of Tumor Progression.
abstract: Inflammation has been closely linked to various forms of cancer. Less is known about the role of inflammation in glioma, especially at the initiation stage. In this review, we first describe the unique features of the immune system in the brain. We then discuss the current understanding of the mechanisms by which glioma cells modulate the immune system, especially how bi-directional communications between immune cells and glioma cells create an immunosuppressed microenvironment that promotes tumor survival and growth. We also address the potential tumor-initiating roles of inflammation in glioma. Finally, we describe several immunotherapy approaches currently being developed to reverse these interactions and stimulate the immune system to eliminate glioma cells.
authors.affiliation: Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
authors.forename: Rui Pedro
authors.initials: RP
authors.lastname: Galvão
authors.forename: Hui
authors.initials: H
authors.lastname: Zong
keywords: Glioma; Immunosuppression; Immunotherapy; Inflammation; Microglia; T cell
references.citation: J Exp Med. 2007 Mar 19;204(3):571-82
references.pmid: 17339406
references.citation: Glia. 2009 Oct;57(13):1458-67
references.pmid: 19306372
references.citation: J Immunol. 2004 Apr 15;172(8):4744-51
references.pmid: 15067050
references.citation: J Clin Neurosci. 2009 Jun;16(6):748-54
references.pmid: 19324552
references.citation: Brain Res. 1992 Jan 31;571(1):19-25
references.pmid: 1377084
references.citation: J Pathol. 2008 Sep;216(1):15-24
references.pmid: 18553315
references.citation: Clin Cancer Res. 2000 Jan;6(1):102-11
references.pmid: 10656438
references.citation: Neurosurgery. 1978 Sep-Oct;3(2):181-6
references.pmid: 703937
references.citation: Semin Cancer Biol. 2012 Feb;22(1):33-40
references.pmid: 22210179
references.citation: J Clin Invest. 2006 Apr;116(4):905-15
references.pmid: 16557302
references.citation: Eur J Immunol. 1999 Apr;29(4):1275-85
references.pmid: 10229095
references.citation: Neurotherapeutics. 2009 Jul;6(3):427-35
references.pmid: 19560733
references.citation: CNS Neurol Disord Drug Targets. 2011 Feb;10(1):108-18
references.pmid: 21143141
references.citation: Exp Cell Res. 2012 May 1;318(8):925-35
references.pmid: 22394507
references.citation: J Transl Med. 2007 Dec 19;5:67
references.pmid: 18093335
references.citation: Neurochem Int. 2010 Nov;57(4):446-50
references.pmid: 20178822
references.citation: Jpn J Cancer Res. 1993 May;84(5):544-8
references.pmid: 8320172
references.citation: Cancer Res. 2008 Apr 1;68(7):2241-9
references.pmid: 18381430
references.citation: Anticancer Res. 2008 Mar-Apr;28(2B):1143-50
references.pmid: 18505050
references.citation: Curr Opin Genet Dev. 2010 Feb;20(1):65-71
references.pmid: 20036794
references.citation: Mult Scler. 2001 Aug;7(4):269-73
references.pmid: 11548988
references.citation: Trends Immunol. 2007 Mar;28(3):138-45
references.pmid: 17276138
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12530-5
references.pmid: 19617536
references.citation: Cancer Cell. 2009 Apr 7;15(4):315-27
references.pmid: 19345330
references.citation: Int J Cancer. 2011 Nov 1;129(9):2290-6
references.pmid: 21190193
references.citation: Int J Cancer. 2008 Apr 15;122(8):1794-802
references.pmid: 18076066
references.citation: Neuro Oncol. 2008 Feb;10(1):10-8
references.pmid: 17951512
references.citation: Cancer Cell. 2010 Dec 14;18(6):669-82
references.pmid: 21156288
references.citation: Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1541-5
references.pmid: 1996355
references.citation: Crit Rev Immunol. 2009;29(1):1-42
references.pmid: 19348609
references.citation: Curr Biol. 2007 Jan 23;17(2):165-72
references.pmid: 17196391
references.citation: Mol Chem Neuropathol. 1994 Feb-Apr;21(2-3):177-88
references.pmid: 8086034
references.citation: Annu Rev Immunol. 2009;27:119-45
references.pmid: 19302036
references.citation: Adv Immunol. 2011;112:73-136
references.pmid: 22118407
references.citation: Am J Pathol. 1999 Nov;155(5):1557-67
references.pmid: 10550313
references.citation: Nat Immunol. 2005 Apr;6(4):345-52
references.pmid: 15785760
references.citation: Cancer Res. 2008 Jul 15;68(14):5955-64
references.pmid: 18632651
references.citation: Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18117-22
references.pmid: 15608062
references.citation: J Neurochem. 1999 Dec;73(6):2348-57
references.pmid: 10582593
references.citation: J Neuroinflammation. 2006 Sep 27;3:27
references.pmid: 17005052
references.citation: J Neurooncol. 1998 Aug;39(1):1-18
references.pmid: 9760066
references.citation: J Mol Neurosci. 1999 Aug-Oct;13(1-2):177-85
references.pmid: 10691304
references.citation: Neuro Oncol. 2006 Jul;8(3):234-43
references.pmid: 16723631
references.citation: J Neurochem. 1998 Nov;71(5):1837-45
references.pmid: 9798907
references.citation: J Neurosurg. 1995 May;82(5):864-73
references.pmid: 7714613
references.citation: Neuro Oncol. 2006 Jul;8(3):261-79
references.pmid: 16775224
references.citation: FASEB J. 2008 Aug;22(8):2843-52
references.pmid: 18390924
references.citation: Nat Rev Cancer. 2009 Nov;9(11):798-809
references.pmid: 19851315
references.citation: Cell Tissue Res. 2008 Jan;331(1):225-41
references.pmid: 17710437
references.citation: Mol Cell Neurosci. 2008 Jul;38(3):374-80
references.pmid: 18499473
references.citation: Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4294-305
references.pmid: 16857805
references.citation: Cancer Cell. 2009 Jan 6;15(1):45-56
references.pmid: 19111880
references.citation: Ann Neurol. 2003 Sep;54(3):388-92
references.pmid: 12953273
references.citation: Int J Oncol. 2009 Jun;34(6):1621-7
references.pmid: 19424580
references.citation: J Neurochem. 2007 May;101(3):771-81
references.pmid: 17250684
references.citation: J Natl Cancer Inst. 2007 Oct 17;99(20):1544-50
references.pmid: 17925535
references.citation: Glia. 2005 Sep;51(4):279-85
references.pmid: 15818597
references.citation: J Neurosurg. 2008 Feb;108(2):311-9
references.pmid: 18240928
references.citation: Science. 2010 Nov 5;330(6005):841-5
references.pmid: 20966214
references.citation: J Neurosci. 2005 Mar 9;25(10):2537-46
references.pmid: 15758163
references.citation: J Clin Invest. 2010 May;120(5):1368-79
references.pmid: 20440079
references.citation: Neuropathol Appl Neurobiol. 1998 Aug;24(4):293-301
references.pmid: 9775395
references.citation: Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1277-81
references.pmid: 18483351
references.citation: Int J Cancer. 1999 Jul 2;82(1):12-6
references.pmid: 10360813
references.citation: Cancer. 2008 Oct 1;113(7 Suppl):1953-68
references.pmid: 18798534
references.citation: J Neuroimmunol. 2002 Dec;133(1-2):39-45
references.pmid: 12446006
references.citation: Eur J Neurosci. 2004 Jul;20(2):317-30
references.pmid: 15233741
references.citation: Eur J Cell Biol. 2004 Aug;83(8):381-7
references.pmid: 15506562
references.citation: Am J Epidemiol. 2004 Jun 15;159(12):1131-9
references.pmid: 15191930
references.citation: J Clin Oncol. 2010 Nov 1;28(31):4722-9
references.pmid: 20921459
references.citation: Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1223-31
references.pmid: 20610043
references.citation: Trends Neurosci. 2007 Nov;30(11):596-602
references.pmid: 17950926
references.citation: Cancer Sci. 2007 Aug;98(8):1226-33
references.pmid: 17517052
references.citation: J Clin Invest. 2012 Oct;122(10):3473-5
references.pmid: 23006324
references.citation: J Neuroimmunol. 2010 Aug 25;225(1-2):195-9
references.pmid: 20537408
references.citation: Nature. 2008 Jul 24;454(7203):436-44
references.pmid: 18650914
references.citation: J Immunol. 1989 Nov 15;143(10):3222-9
references.pmid: 2809198
references.citation: Cell. 2011 Jul 22;146(2):209-21
references.pmid: 21737130
references.citation: Cancer Res. 1990 Oct 15;50(20):6683-8
references.pmid: 2208133
references.citation: Neuroscience. 2009 Feb 6;158(3):1021-9
references.pmid: 18662748
references.citation: J Biol Chem. 2004 Oct 22;279(43):44327-34
references.pmid: 15280387
references.citation: Cancer Cell. 2010 Dec 14;18(6):655-68
references.pmid: 21156287
references.citation: J Neurosci. 2007 Aug 29;27(35):9301-9
references.pmid: 17728444
references.citation: J Neurosci. 2009 Sep 16;29(37):11511-22
references.pmid: 19759299
references.citation: J Neuroimmunol. 2000 Nov 1;111(1-2):177-85
references.pmid: 11063836
references.citation: Acta Neuropathol. 2002 Feb;103(2):171-8
references.pmid: 11810184
references.citation: Development. 2001 Dec;128(24):5201-12
references.pmid: 11748155
references.citation: J Neurosci. 2003 May 15;23(10):4034-43
references.pmid: 12764090
references.citation: Clin Cancer Res. 2008 May 15;14(10):3098-104
references.pmid: 18483377
references.citation: Acta Neurochir (Wien). 1996;138(1):50-6
references.pmid: 8686525
references.citation: Immunol Rev. 2012 Mar;246(1):379-400
references.pmid: 22435567
references.citation: Nature. 2011 Dec 21;480(7378):480-9
references.pmid: 22193102
references.citation: J Neuropathol Exp Neurol. 2008 Dec;67(12):1113-21
references.pmid: 19018243
references.citation: BMC Neurosci. 2006 Sep 20;7:64
references.pmid: 16987412
references.citation: Nat Neurosci. 2005 Jun;8(6):752-8
references.pmid: 15895084
references.citation: Int J Dev Neurosci. 1999 Aug-Oct;17(5-6):547-56
references.pmid: 10571416
references.citation: J Neuroimmune Pharmacol. 2009 Dec;4(4):399-418
references.pmid: 19655259
references.citation: Eur J Immunol. 2010 Nov;40(11):2976-85
references.pmid: 21061431
references.citation: N Engl J Med. 2011 Feb 17;364(7):627-37
references.pmid: 21175304
references.citation: Glia. 2006 Nov 1;54(6):526-35
references.pmid: 16906541
references.citation: Curr Neurol Neurosci Rep. 2010 Jul;10(4):259-66
references.pmid: 20424975
references.citation: Acta Neuropathol. 1997 May;93(5):518-27
references.pmid: 9144591
references.citation: Adv Exp Med Biol. 2012;746:53-76
references.pmid: 22639159
references.citation: Cancer Res. 2002 Jun 15;62(12):3347-50
references.pmid: 12067971
references.citation: Glia. 2012 Mar;60(3):502-14
references.pmid: 22379614
references.citation: Curr Opin Immunol. 2007 Aug;19(4):454-9
references.pmid: 17628461
references.citation: Oncogene. 2011 Aug 11;30(32):3537-48
references.pmid: 21423202
references.citation: Curr Opin Immunol. 2012 Jun;24(3):297-302
references.pmid: 22341735
references.citation: Cancer Immunol Immunother. 2008 Jan;57(1):123-31
references.pmid: 17522861
references.citation: Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15983-8
references.pmid: 14668448
references.citation: Cell. 2010 Mar 19;140(6):883-99
references.pmid: 20303878
references.citation: Neurocirugia (Astur). 2004 Aug;15(4):378-83
references.pmid: 15368029
references.citation: J Neuroimmunol. 2001 Nov 1;120(1-2):19-24
references.pmid: 11694315
references.citation: Science. 2005 Aug 26;309(5739):1380-4
references.pmid: 16123302
references.citation: Anticancer Res. 1997 Sep-Oct;17(5A):3217-24
references.pmid: 9413151
references.citation: Nat Neurosci. 2001 Nov;4(11):1116-22
references.pmid: 11600888
references.citation: Neurosurgery. 1999 May;44(5):1077-82; discussion 1082-3
references.pmid: 10232541
references.citation: Mol Cell Neurosci. 2006 Jan;31(1):149-60
references.pmid: 16297637
references.citation: Science. 2005 May 27;308(5726):1314-8
references.pmid: 15831717
references.citation: N Engl J Med. 2008 Jul 31;359(5):539-41
references.pmid: 18669440
references.citation: Tumori. 2004 Jul-Aug;90(4):416-9
references.pmid: 15510986
references.citation: Blood. 2011 Sep 15;118(11):3003-12
references.pmid: 21768296
references.citation: Neurosurgery. 2002 Jan;50(1):158-64; discussion 164-6
references.pmid: 11844246
references.citation: Cell Stem Cell. 2009 Nov 6;5(5):504-14
references.pmid: 19896441
references.citation: J Clin Oncol. 2010 Jul 1;28(19):3167-75
references.pmid: 20516446
references.citation: J Neurosci. 2009 Feb 18;29(7):2089-102
references.pmid: 19228962
references.citation: J Neuroimmunol. 1994 Jul;52(2):153-64
references.pmid: 8034755
references.citation: J Biol Chem. 2002 Dec 20;277(51):49481-7
references.pmid: 12388552
references.citation: J Neurosci. 2006 Sep 20;26(38):9703-12
references.pmid: 16988041
references.citation: J Neurosurg. 2006 Sep;105(3):430-7
references.pmid: 16961139