title: Hydrogen-rich saline protects against ultraviolet B radiation injury in rats.
abstract: Exposure of skin to solar ultraviolet (UV) radiation induces photo-damage. Ultraviolet B (UVB) is the major component of UV radiation which induces the production of reactive oxygen species (ROS) and plays an important role in photo-damage. Hydrogen gas reduces ROS and alleviates inflammation. In this study, we sought to demonstrate that hydrogen-rich saline has the effect on skin injuries caused by UVB radiation. UVB radiation was irradiated on female C57BL/6 rats to induce skin injury. Hydrogen-rich saline and nitrogen-rich saline were administered to rats by intraperitoneal injection. Skin damage was detected by microscope after injury. UVB radiation had a significant affection in tumor necrosis factor alpha, interleukin (IL)-1β and IL-6 levels, tissue superoxide dismutase, malondialdehyde and nitric oxide activity. Hydrogen-rich saline had a protective effect by altering the levels of these markers and relieved morphological skin injury. Hydrogen-rich saline protected against UVB radiation injury, possibly by reducing inflammation and oxidative stress.
authors.affiliation: Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;
authors.forename: Ze
authors.initials: Z
authors.lastname: Guo
authors.forename: Bingrong
authors.initials: B
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xuejun
authors.initials: X
authors.lastname: Sun
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
keywords: hydrogen-rich saline; oxidative stress; photo-damage; skin; ultraviolet B
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