title: Obesity and melanoma: exploring molecular links.
abstract: Obesity is now a major health problem due to its rapidly increasing incidence worldwide and severe consequences. Among many conditions associated with obesity are some cancers including melanoma. Both genetic defects and environmental risk factors are involved in the carcinogenesis of melanoma. Activation of multiple signal pathways such as the PI3K/Akt and MAPK pathways are necessary for the initiation of melanoma. Activation of the MAPK pathway as a result of activating mutations in BRAF is commonly seen in melanoma though it alone is not sufficient to cause malignant transformation of melanocytes. Obesity can result in the activation of many signal pathways including PI3K/Akt, MAPK, and STAT3. The activation of these pathways may have a synergistic effect with the genetic defects thereby increasing the incidence of melanoma.
authors.affiliation: School of Biomedical Sciences, University of Queensland, Sir William MacGregor Building 64, St Lucia Campus, Brisbane, QLD, 4072, Australia.
authors.forename: Jiezhong
authors.initials: J
authors.lastname: Chen
authors.forename: Mengna
authors.initials: M
authors.lastname: Chi
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Xu Dong
authors.initials: XD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D006801:Humans; D008545:Melanoma / Q000235:genetics / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
chemical_list: D050796:STAT3 Transcription Factor; D020928:Mitogen-Activated Protein Kinases
keywords: MAPK; MELANOMA; OBESITY; PI3K/AKT; STAT3