title: Reliability and validity of the TIMPSI for infants with spinal muscular atrophy type I.
abstract: OBJECTIVE
  This study examined the reliability and validity of the Test of Infant Motor Performance Screening Items (TIMPSI) in infants with type I spinal muscular atrophy (SMA).
  
  
  METHODS
  After training, 12 evaluators scored 4 videos of infants with type I SMA to assess interrater reliability. Intrarater and test-retest reliability was further assessed for 9 evaluators during a SMA type I clinical trial, with 9 evaluators testing a total of 38 infants twice. Relatedness of the TIMPSI score to ability to reach and ventilatory support was also examined.
  
  
  RESULTS
  Excellent interrater video score reliability was noted (intraclass correlation coefficient, 0.97-0.98). Intrarater reliability was excellent (intraclass correlation coefficient, 0.91-0.98) and test-retest reliability ranged from r = 0.82 to r = 0.95. The TIMPSI score was related to the ability to reach (P ≤ .05).
  
  
  CONCLUSIONS
  The TIMPSI can reliably be used to assess motor function in infants with type I SMA. In addition, the TIMPSI scores are related to the ability to reach, an important functional skill in children with type I SMA.
authors.affiliation: Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. k-krosschell@northwestern.edu
authors.forename: Kristin J
authors.initials: KJ
authors.lastname: Krosschell
authors.forename: Jo Anne
authors.initials: JA
authors.lastname: Maczulski
authors.forename: Charles
authors.initials: C
authors.lastname: Scott
authors.forename: Wendy
authors.initials: W
authors.lastname: King
authors.forename: Jill T
authors.initials: JT
authors.lastname: Hartman
authors.forename: Laura E
authors.initials: LE
authors.lastname: Case
authors.forename: Donata
authors.initials: D
authors.lastname: Viazzo-Trussell
authors.forename: Janine
authors.initials: J
authors.lastname: Wood
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Roman
authors.forename: Eva
authors.initials: E
authors.lastname: Hecker
authors.forename: Marianne
authors.initials: M
authors.lastname: Meffert
authors.forename: Maude
authors.initials: M
authors.lastname: Léveillé
authors.forename: Krista
authors.initials: K
authors.lastname: Kienitz
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Swoboda
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009048:Motor Skills; D015588:Observer Variation; D026741:Physical Therapy Modalities; D015203:Reproducibility of Results; D014897:Spinal Muscular Atrophies of Childhood / Q000175:diagnosis* / Q000534:rehabilitation; D011795:Surveys and Questionnaires; D013997:Time Factors
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