title: Dynamic noise, chaos and parameter estimation in population biology.
abstract: We revisit the parameter estimation framework for population biological dynamical systems, and apply it to calibrate various models in epidemiology with empirical time series, namely influenza and dengue fever. When it comes to more complex models such as multi-strain dynamics to describe the virus-host interaction in dengue fever, even the most recently developed parameter estimation techniques, such as maximum likelihood iterated filtering, reach their computational limits. However, the first results of parameter estimation with data on dengue fever from Thailand indicate a subtle interplay between stochasticity and the deterministic skeleton. The deterministic system on its own already displays complex dynamics up to deterministic chaos and coexistence of multiple attractors.
authors.affiliation: Centro de Matemática e Aplicações Fundamentais , Universidade de Lisboa, Avenida Prof. Gama Pinto 2, 1649-003 Lisbon , Portugal.
authors.forename: N
authors.initials: N
authors.lastname: Stollenwerk
authors.forename: M
authors.initials: M
authors.lastname: Aguiar
authors.forename: S
authors.initials: S
authors.lastname: Ballesteros
authors.forename: J
authors.initials: J
authors.lastname: Boto
authors.forename: B
authors.initials: B
authors.lastname: Kooi
authors.forename: L
authors.initials: L
authors.lastname: Mateus
keywords: dengue fever; deterministic chaos; epidemiology; influenza; likelihood; master equation
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