title: Amlodipine increases vitamin D levels more than valsartan in newly diagnosed hypertensive patients: pointing to an additional effect on bone metabolism or a novel marker of inflammation?
abstract: Hypertension is a major challenge for public health. Appropriate antihypertensive treatment seem to provide a better life with lower morbidity and mortality rates. Another pathologic condition, osteoporosis, mainly affects postmenouposal women, and constitutes a growing body of risks after a particular age. As bone is a dynamic organ system that is directly related to calcium and phosphor metabolism, imbalance in these two parameters upon aging or menopause finally may lead to osteoporosis. Today, both osteoporosis and high blood pressure are major morbidities, especially in the elderly population. There are some intriguing results on the effects of antihypertensive agents on bone metabolism in the literature. In this study, we aimed to investigate the effects of widely used antihypertensive agents, valsartan and amlodipine on vitamin D levels in newly diagnosed hypertensive population. We found that amlodipine increased vitamin D levels significantly in patients with a newly diagnosed hypertension on a 12-week treatment duration compared to valsartan.
authors.affiliation: Department of Internal Medicine, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey.
authors.forename: Seyit Ahmet
authors.initials: SA
authors.lastname: Ay
authors.forename: Murat
authors.initials: M
authors.lastname: Karaman
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cakar
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.forename: Erol
authors.initials: E
authors.lastname: Arslan
authors.forename: Fatih
authors.initials: F
authors.lastname: Bulucu
authors.forename: Seref
authors.initials: S
authors.lastname: Demirbas
authors.forename: Turgay
authors.initials: T
authors.lastname: Celik
authors.forename: Mehmet Ilkin
authors.initials: MI
authors.lastname: Naharci
authors.forename: Sait
authors.initials: S
authors.lastname: Demirkol
authors.forename: Omer
authors.initials: O
authors.lastname: Kurt
authors.forename: Ergun
authors.initials: E
authors.lastname: Bozoglu
mesh_terms: D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000494:pharmacology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013777:Tetrazoles / Q000494:pharmacology / Q000627:therapeutic use*; D014633:Valine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000068756:Valsartan; D014807:Vitamin D / Q000097:blood*
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D013777:Tetrazoles; D014807:Vitamin D; D017311:Amlodipine; D000068756:Valsartan; D014633:Valine