title: New triterpene glycoside and other chemical constituents from the leaves of Swartzia apetala Raddi var. glabra.
abstract: A new triterpene saponin (1) was isolated from a methanol extract of Swartzia apetala Raddi var. glabra, together with the flavonoids mauritianin (2), kaempferol (3) and the triterpene saponin β-D-glucopyranosyl 3β-hydroxy-olean-12-en-28-oate (4). These compounds were characterised on the basis of their spectral data, mainly one-dimension (1D; (1)H, (13)C, APT) and two-dimension (2D; (1)H-(1)H-COSY, HMQC and HMBC) nuclear magnetic resonance (NMR) and HR-ESI-MS, and comparison with values in the literature. The analysis by HR-ESI-MS showed a mass compatible with that of triterpene saponin 1. This proposal was supported by molecular modelling. LC-HR-ESI-MS experiment was also used to evaluate the purity of 1 and allowed to speculate about the possibility of the presence of 5 in very small quantity. The extract and four compounds were assayed for antifungal activity against nine strains of Candida spp.
authors.affiliation: a Laboratório de Química de Produtos Naturais (LQPN), Departamento de Química, ICE-Universidade Federal Rural do Rio de Janeiro , UFRRJ, BR 465 KM.07, 23890-000 , Seropédica-RJ , Brazil.
authors.forename: Marcelo F
authors.initials: MF
authors.lastname: de Araújo
authors.forename: Ivo J
authors.initials: IJ
authors.lastname: Curcino Vieira
authors.forename: Carlos M R
authors.initials: CM
authors.lastname: Sant'Anna
authors.forename: Daniel Rosa
authors.initials: DR
authors.lastname: da Silva
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Vitorino Maia
authors.forename: Raimundo
authors.initials: R
authors.lastname: Braz-Filho
authors.forename: Olney
authors.initials: O
authors.lastname: Vieira-da-Motta
authors.forename: Leda
authors.initials: L
authors.lastname: Mathias
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D000432:Methanol; D008958:Models, Molecular; D015394:Molecular Structure; D053147:Plant Exudates; D018515:Plant Leaves / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D005419:Flavonoids; D053147:Plant Exudates; D012503:Saponins; D014315:Triterpenes; D000432:Methanol