title: Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194.
abstract: Two novel reddish-orange alkaloids, mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (2) was active in inhibiting the growth of cancer cell lines with IC50 values in the range 0.60-0.78 μM.
authors.affiliation: Laboratory of Tropical Bioorganic Chemistry, Faculty of Natural, Exact Science and Technology, University of Panama, Panama.
authors.forename: Humberto E
authors.initials: HE
authors.lastname: Ortega
authors.forename: Paul R
authors.initials: PR
authors.lastname: Graupner
authors.forename: Yumi
authors.initials: Y
authors.lastname: Asai
authors.forename: Karen
authors.initials: K
authors.lastname: Tendyke
authors.forename: Dayong
authors.initials: D
authors.lastname: Qiu
authors.forename: Young Yongchun
authors.initials: YY
authors.lastname: Shen
authors.forename: Nivia
authors.initials: N
authors.lastname: Rios
authors.forename: A Elizabeth
authors.initials: AE
authors.lastname: Arnold
authors.forename: Phyllis D
authors.initials: PD
authors.lastname: Coley
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Kursar
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
authors.forename: Luis
authors.initials: L
authors.lastname: Cubilla-Rios
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010176:Panama; D013055:Spectrophotometry, Infrared
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; C582698:mycoleptodiscin A; C582697:mycoleptodiscin B