title: Hypolipidemic and antioxidant activities of polysaccharides from Rosae Laevigatae Fructus in rats.
abstract: Two major fractions (RLP-1 and RLP-2) were obtained by purifying the crude polysaccharides extracted from a traditional Chinese herb Rosae Laevigatae Fructus. The average molecular weight of RLP-1 and RLP-2 was 21.5 kDa and 16.1 kDa, respectively. Monosaccharide analysis indicated that RLP-1 was composed of xylose, mannose and galactose in the molar ratio of 1:11:8, while RLP-2 was only a glucan. Oral administration of RLP-1 could significantly decrease levels of serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C), inhibit hepatic lipid accumulation, increase antioxidant lipids and up-regulate expressions of peroxisome proliferator-activated receptor-γ (PPAR-γ) and lipoprotein lipase (LPL) in hyperlipidemia rats. These results suggest that RLP-1 improve hyperlipidemia possibly through regulating PPAR-mediated lipid metabolism. Therefore, could be explored as a possible agent for hyperlipidemia.
authors.affiliation: Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Chen-Huan
authors.initials: CH
authors.lastname: Yu
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Dai
authors.forename: Qin
authors.initials: Q
authors.lastname: Chen
authors.forename: Jia-Na
authors.initials: JN
authors.lastname: Zang
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Deng
authors.forename: Yue-Huan
authors.initials: YH
authors.lastname: Liu
authors.forename: Hua-Zhong
authors.initials: HZ
authors.lastname: Ying
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D015870:Gene Expression / Q000235:genetics; D005979:Glutathione Peroxidase / Q000378:metabolism; D006860:Hydrogen Bonding; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects / Q000235:genetics; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008148:Lovastatin / Q000494:pharmacology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008970:Molecular Weight; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027824:Rosaceae / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents; D047495:PPAR gamma; D011134:Polysaccharides; D008315:Malondialdehyde; D008148:Lovastatin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D008071:Lipoprotein Lipase