title: Acoustic radiation force elasticity imaging in diagnostic ultrasound.
abstract: The development of ultrasound-based elasticity imaging methods has been the focus of intense research activity since the mid-1990s. In characterizing the mechanical properties of soft tissues, these techniques image an entirely new subset of tissue properties that cannot be derived with conventional ultrasound techniques. Clinically, tissue elasticity is known to be associated with pathological condition and with the ability to image these features in vivo; elasticity imaging methods may prove to be invaluable tools for the diagnosis and/or monitoring of disease. This review focuses on ultrasound-based elasticity imaging methods that generate an acoustic radiation force to induce tissue displacements. These methods can be performed noninvasively during routine exams to provide either qualitative or quantitative metrics of tissue elasticity. A brief overview of soft tissue mechanics relevant to elasticity imaging is provided, including a derivation of acoustic radiation force, and an overview of the various acoustic radiation force elasticity imaging methods.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC, USA. joshua.doherty@duke.edu
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Doherty
authors.forename: Gregg E
authors.initials: GE
authors.lastname: Trahey
authors.forename: Kathryn R
authors.initials: KR
authors.lastname: Nightingale
authors.forename: Mark L
authors.initials: ML
authors.lastname: Palmeri
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008099:Liver / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D014465:Ultrasonics / Q000379:methods*; D016217:Ultrasonography, Mammary
references.citation: J Acoust Soc Am. 2001 Jul;110(1):625-34
references.pmid: 11508987
references.citation: Ultrasound Med Biol. 2009 Feb;35(2):219-29
references.pmid: 19081665
references.citation: Science. 1998 Apr 3;280(5360):82-5
references.pmid: 9525861
references.citation: Ultrasound Med Biol. 2010 May;36(5):802-13
references.pmid: 20381950
references.citation: Curr Med Imaging Rev. 2012;8(1):16-26
references.pmid: 25364321
references.citation: Ultrason Imaging. 2007 Apr;29(2):87-104
references.pmid: 17679324
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Nov;53(11):2065-79
references.pmid: 17091842
references.citation: Ultrasound Med Biol. 2012 Jan;38(1):50-61
references.pmid: 22104533
references.citation: Ultraschall Med. 2011 Apr;32(2):167-75
references.pmid: 21321842
references.citation: J Acoust Soc Am. 2010 Mar;127(3):1228-38
references.pmid: 20329821
references.citation: Curr Med Imaging Rev. 2011 Nov;7(4):255-282
references.pmid: 22308105
references.citation: Ultrasonics. 2002 May;40(1-8):859-65
references.pmid: 12160059
references.citation: Phys Med Biol. 2012 Mar 7;57(5):1263-82
references.pmid: 22345425
references.citation: Dig Liver Dis. 2011 Jun;43(6):491-7
references.pmid: 21439919
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Jan;56(1):55-62
references.pmid: 19213632
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2008 Jul;55(7):1597-610
references.pmid: 18986950
references.citation: J Acoust Soc Am. 2005 May;117(5):2705-12
references.pmid: 15957738
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2009 May;56(5):931-44
references.pmid: 19473912
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2004 May;51(5):551-65
references.pmid: 15217233
references.citation: Prog Biophys Mol Biol. 2007 Jan-Apr;93(1-3):212-55
references.pmid: 16934858
references.citation: Ultrasound Med Biol. 2003 Dec;29(12):1715-23
references.pmid: 14698339
references.citation: IEEE Trans Med Imaging. 2002 Jan;21(1):1-8
references.pmid: 11838661
references.citation: Med Phys. 2011 May;38(5):2563-71
references.pmid: 21776792
references.citation: J R Soc Interface. 2011 Nov 7;8(64):1521-49
references.pmid: 21680780
references.citation: Ann Biomed Eng. 2004 May;32(5):696-705
references.pmid: 15171624
references.citation: IEEE Trans Biomed Eng. 2011 Feb;58(2):235-42
references.pmid: 20595086
references.citation: Liver Transpl. 2012 May;18(5):566-76
references.pmid: 22271627
references.citation: J Acoust Soc Am. 2011 Mar;129(3):1344-54
references.pmid: 21428498
references.citation: Interface Focus. 2011 Aug 6;1(4):553-64
references.pmid: 22419986
references.citation: J Viral Hepat. 2010 Jul;17(7):469-74
references.pmid: 19780940
references.citation: World J Gastroenterol. 2008 Nov 14;14(42):6513-7
references.pmid: 19030204
references.citation: Curr Med Imaging Rev. 2011 Nov 1;7(4):328-339
references.pmid: 22545033
references.citation: J Hepatol. 2011 Sep;55(3):666-672
references.pmid: 21256907
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Jun;58(6):1169-81
references.pmid: 21693399
references.citation: Can J Gastroenterol. 2008 Sep;22(9):753-7
references.pmid: 18818788
references.citation: Ultrason Imaging. 2010 Jul;32(3):177-89
references.pmid: 20718246
references.citation: Ultrason Imaging. 2008 Apr;30(2):63-77
references.pmid: 18939609
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2004 Apr;51(4):396-409
references.pmid: 15139541
references.citation: Eur J Radiol. 2011 Dec;80(3):e226-30
references.pmid: 20971591
references.citation: J Ultrasound Med. 2008 Apr;27(4):503-15
references.pmid: 18359906
references.citation: Prog Biophys Mol Biol. 2007 Jan-Apr;93(1-3):176-91
references.pmid: 16965806
references.citation: Ultrasound Med Biol. 1990;16(3):231-9
references.pmid: 1694603
references.citation: Ultrasound Med Biol. 2003 Oct;29(10):1405-13
references.pmid: 14597337
references.citation: Annu Rev Biomed Eng. 2003;5:57-78
references.pmid: 12704084
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Oct;52(10):1699-712
references.pmid: 16382621
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2012 Jul;59(7):1602-8
references.pmid: 22828855
references.citation: Clin Hemorheol Microcirc. 2009;43(1-2):95-107
references.pmid: 19713604
references.citation: Radiol Med. 2010 Sep;115(6):889-97
references.pmid: 20082227
references.citation: Clin Gastroenterol Hepatol. 2008 Sep;6(9):1027-35
references.pmid: 18456573
references.citation: Ultrasound Med Biol. 1991;17(5):497-500
references.pmid: 1962351
references.citation: Ultrason Imaging. 1991 Apr;13(2):111-34
references.pmid: 1858217
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Dec;58(12):2608-19
references.pmid: 23443697
references.citation: Ultrasound Med Biol. 2008 Apr;34(4):546-58
references.pmid: 18222031
references.citation: Ultrasound Med Biol. 2007 Nov;33(11):1706-19
references.pmid: 17698282
references.citation: J Viral Hepat. 2007 May;14(5):360-9
references.pmid: 17439526
references.citation: Ultrasound Med Biol. 2010 Apr;36(4):576-88
references.pmid: 20350685
references.citation: Ann Hepatol. 2010 Jul-Sep;9(3):289-93
references.pmid: 20720270
references.citation: J Biomech. 2013 Jan 4;46(1):83-90
references.pmid: 23122224
references.citation: Radiology. 2009 Aug;252(2):595-604
references.pmid: 19703889
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Jun;53(6):1103-17
references.pmid: 16846143
references.citation: Curr Med Imaging Rev. 2011 Nov 1;7(4):350-359
references.pmid: 22423235
references.citation: Ultrason Imaging. 2005 Apr;27(2):75-88
references.pmid: 16231837
references.citation: Hepatology. 2012 Jan;55(1):199-208
references.pmid: 21898479
references.citation: Ultrason Imaging. 2009 Jul;31(3):172-82
references.pmid: 19771960
references.citation: Dig Liver Dis. 2009 Dec;41(12):863-6
references.pmid: 19482565
references.citation: Ultrason Imaging. 1986 Apr;8(2):73-85
references.pmid: 2946098
references.citation: Phys Med Biol. 2008 Mar 21;53(6):1773-93
references.pmid: 18367802
references.citation: Ultrasound Med Biol. 2012 Feb;38(2):296-311
references.pmid: 22178166
references.citation: Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):765-70
references.pmid: 17438875
references.citation: Invest Radiol. 2008 Apr;43(4):243-52
references.pmid: 18340248
references.citation: Curr Med Imaging Rev. 2012 Feb 1;8(1):27-36
references.pmid: 22866026
references.citation: J Gastrointestin Liver Dis. 2008 Dec;17(4):395-9
references.pmid: 19104699
references.citation: Liver Int. 2010 Apr;30(4):538-45
references.pmid: 19874490
references.citation: Eur J Radiol. 2011 Nov;80(2):241-4
references.pmid: 20630676
references.citation: Ultraschall Med. 2011 Jan;32 Suppl 1:S46-52
references.pmid: 20603783
references.citation: Acad Radiol. 2011 Jul;18(7):810-5
references.pmid: 21419668
references.citation: Clin Chim Acta. 2010 May 2;411(9-10):638-44
references.pmid: 20096680
references.citation: J Viral Hepat. 2012 Jan;19 Suppl 1:18-32
references.pmid: 22233410
references.citation: J Cardiovasc Electrophysiol. 2010 May;21(5):557-63
references.pmid: 20021518
references.citation: J Viral Hepat. 2010 Apr;17(4):280-6
references.pmid: 19732322
references.citation: Ultrasound Med Biol. 2009 Feb;35(2):278-95
references.pmid: 19026483
references.citation: Ultrasound Med Biol. 2002 Nov-Dec;28(11-12):1475-84
references.pmid: 12498943
references.citation: Dig Liver Dis. 2009 Mar;41(3):217-25
references.pmid: 18672413
references.citation: J Acoust Soc Am. 2004 Jun;115(6):2781-5
references.pmid: 15237800
references.citation: IEEE Trans Med Imaging. 2009 Mar;28(3):313-22
references.pmid: 19244004
references.citation: Ultrasound Med Biol. 2004 Sep;30(9):1163-71
references.pmid: 15550320
references.citation: Ultrason Imaging. 1982 Jan;4(1):71-82
references.pmid: 7199773
references.citation: Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6603-8
references.pmid: 10359758
references.citation: Ultrason Imaging. 2009 Apr;31(2):131-50
references.pmid: 19630254
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2012 Aug;59(8):1729-40
references.pmid: 22899119
references.citation: Liver Transpl. 2012 Mar;18(3):323-31
references.pmid: 22140010
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Dec;57(12):2662-70
references.pmid: 21156362
references.citation: Magn Reson Med. 2001 Feb;45(2):299-310
references.pmid: 11180438
references.citation: IEEE Trans Med Imaging. 2002 Sep;21(9):1022-30
references.pmid: 12564870
references.citation: Ultrasound Med Biol. 2003 Dec;29(12):1705-13
references.pmid: 14698338
references.citation: Radiology. 2012 Feb;262(2):435-49
references.pmid: 22282182
references.citation: Ultrasound Med Biol. 2012 Feb;38(2):312-23
references.pmid: 22178168
references.citation: J Ultrasound Med. 2012 Feb;31(2):289-94
references.pmid: 22298873
references.citation: Ultrasound Med Biol. 2002 Feb;28(2):227-35
references.pmid: 11937286
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Oct;58(10):2032-5
references.pmid: 21989866
references.citation: Phys Med Biol. 2008 Jan 7;53(1):279-93
references.pmid: 18182703
references.citation: Ultrasound Med Biol. 2010 Feb;36(2):202-8
references.pmid: 20018432
references.citation: Gastroenterology. 2005 Feb;128(2):343-50
references.pmid: 15685546
references.citation: Ultrasound Med Biol. 1998 Nov;24(9):1419-35
references.pmid: 10385964
references.citation: Ultrasound Med Biol. 1982;8(3):263-71
references.pmid: 7101574
references.citation: Eur J Radiol. 2013 Feb;82(2):335-41
references.pmid: 23116805
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2008 Oct;55(10):2177-90
references.pmid: 18986866
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2003 Jun;50(6):631-41
references.pmid: 12839175
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Apr;52(4):642-52
references.pmid: 16060513
references.citation: IEEE Trans Biomed Eng. 2008 Nov;55(11):2584-92
references.pmid: 18990628
references.citation: Clin Hemorheol Microcirc. 2010;46(2-3):159-68
references.pmid: 21135491
references.citation: J Viral Hepat. 2011 Jan;18(1):61-9
references.pmid: 20196798
references.citation: Ultrasound Med Biol. 2008 Sep;34(9):1373-86
references.pmid: 18395961
references.citation: Aliment Pharmacol Ther. 2006 Aug 1;24(3):513-8
references.pmid: 16886917
references.citation: Aliment Pharmacol Ther. 2008 Jul;28(1):51-61
references.pmid: 18410556
references.citation: J Gastrointestin Liver Dis. 2009 Sep;18(3):303-10
references.pmid: 19795024
references.citation: World J Gastroenterol. 2009 Nov 28;15(44):5525-32
references.pmid: 19938190
references.citation: Ultrasound Med Biol. 2009 May;35(5):707-16
references.pmid: 19243877
references.citation: IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Jul;53(7):1300-13
references.pmid: 16889337
references.citation: Ultrasound Med Biol. 1995;21(6):745-51
references.pmid: 8571462
references.citation: Liver Int. 2010 Nov;30(10):1471-80
references.pmid: 20807336