title: Enantioselective iron-catalyzed azidation of β-keto esters and oxindoles.
abstract: The first example of Fe-catalyzed enantioselective azidations of β-keto esters and oxindoles using a readily available N3-transfer reagent is reported. A number of α-azido-β-keto esters were obtained with up to 93% ee, and this methodology also generates 3-substitued 3-azidooxindoles with high enantioselectivities (up to 94%).
authors.affiliation: Catalysis Research Laboratory, Im Neuenheimer Feld 584, 69120 Heidelberg, Germany.
authors.forename: Qing-Hai
authors.initials: QH
authors.lastname: Deng
authors.forename: Tim
authors.initials: T
authors.lastname: Bleith
authors.forename: Hubert
authors.initials: H
authors.lastname: Wadepohl
authors.forename: Lutz H
authors.initials: LH
authors.lastname: Gade
mesh_terms: D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: D001386:Azides; D004952:Esters; D005296:Ferrous Compounds; D007211:Indoles; D007659:Ketones; D000078183:Oxindoles; C022960:2-oxindole