title: Dose dependent morphological effects of alpha lipoic acid on vasospastic femoral artery in rats.
abstract: OBJECTIVE
  The dose dependent effects of alpha lipoic acid (α-LA) were investigated morphologically on rat vasospasm model.
  
  
  METHODS
  32 rats were divided into four groups: group I=control; group II=vasospasm; group III=vasospasm +low dose (20 mg/kg) intraperitoneal α-LA administered; and group IV=vasospasm +high dose (100 mg/kg) intraperitoneal α-LA administered. Histological and morphometric examinations were carried out for each groups under light microscope.
  
  
  RESULTS
  The mean vascular wall thickness displayed significant increase in group II and III compared with group I (p < .05). Statistical comparison of group II and IV, regarding vascular wall thickness showed a significant decrease in group IV, and regarding vascular lumen area showed a significant increase in group IV (p < .05).
  
  
  CONCLUSIONS
  It is demonstrated α-LA reduces the effects of vasospasm in high dose treatment group by decreasing the wall thickness and increasing the lumen surface area. The present study suggests that adequate dose of α-LA is a potential therapeutic agent in experimental vasospasm model.
authors.affiliation: Haseki Education and Research Hospital, Department of Neurosurgery, Istanbul, Turkey.
authors.forename: Tugrul
authors.initials: T
authors.lastname: Ton
authors.forename: Aysegul Ozdemir
authors.initials: AO
authors.lastname: Ovalioglu
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ton
authors.forename: Turgay
authors.initials: T
authors.lastname: Bilge
authors.forename: Talat
authors.initials: T
authors.lastname: Kiris
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005263:Femoral Artery / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D008063:Thioctic Acid / Q000494:pharmacology*; D014652:Vascular Diseases / Q000473:pathology*
chemical_list: D001786:Blood Glucose; D008063:Thioctic Acid