title: Influence of hypertension and type 2 diabetes mellitus on cerebrovascular reactivity in diabetics with retinopathy.
abstract: OBJECTIVE
  Cerebrovascular reactivity (CVR) provides information on the intracerebral arterioles capacity to react to vasodilatory stimuli. The current study aimed to investigate the influence of hypertension and type 2 diabetes mellitus on CVR in diabetics with retinopathy.
  
  
  METHODS
  Retrospective analysis of data prospectively collected over a 1-year period.
  
  
  METHODS
  Subjects were classified into four groups each comprised of 30 participants: diabetic retinopathy with hypertension (DRH), diabetic retinopathy without hypertension (DR), hypertension without diabetes mellitus (H), and healthy controls without diabetes and hypertension (C). CVR was estimated in relation to the increase in the mean flow velocity compared with the basal velocity in both middle cerebral arteries during hypercapnia.
  
  
  RESULTS
  In the DRH group, the mean (SD) increase in CVR was 8.8 (2.49) cm/s, in the H group 14.4 (2.59) cm/s and in the DR group 9.7 (2.97) cm/s. The analysis of variance showed significant differences among the groups in blood flow velocity after a breath-holding test (F=89.83; df=3.116; P < .001).
  
  
  CONCLUSIONS
  Diabetes mellitus influences CVR more than hypertension.
authors.affiliation: Department of Neurology, General Hospital Dubrovnik, Dubrovnik, Croatia.
authors.forename: Mira
authors.initials: M
authors.lastname: Ivankovic
authors.forename: Maja
authors.initials: M
authors.lastname: Radman
authors.forename: Antonela
authors.initials: A
authors.lastname: Gverovic-Antunica
authors.forename: Sanda
authors.initials: S
authors.lastname: Tesanovic
authors.forename: Gorana
authors.initials: G
authors.lastname: Trgo
authors.forename: Vida
authors.initials: V
authors.lastname: Demarin
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D006935:Hypercapnia; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000503:physiopathology*; D012189:Retrospective Studies
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