title: Iodine supplementation during pregnancy and infant neuropsychological development. INMA Mother and Child Cohort Study.
abstract: Iodine supplementation during pregnancy is a common practice in developed countries. However, scant evidence is available regarding the safety and effectiveness of maternal iodine supplementation with regard to child neuropsychological development. We previously reported an inverse association between iodine supplementation and the psychomotor development of infants in a birth cohort from Valencia, Spain. In the present study, we assessed this association in a wider sample of mother and child pairs from 3 other regions in Spain. Neuropsychological development was assessed using the Bayley Scales of Infant Development in 1,519 infants (median age, 16 months) between 2006 and 2009. In multivariate analyses, maternal consumption of 150 μg/day or more of iodine from supplements was related to a 1.5-fold increase in the odds of a psychomotor score less than 85 (95% confidence interval: 0.8, 2.9) and to a 1.7-fold increase in the odds of a mental score less than 85 (95% confidence interval: 0.9, 3.0). Findings previously reported in the Valencia cohort were only partially verified. The results of the present study suggest that, at least in these regions, iodine supplementation does not improve infant neuropsychological development at 1 year of age. Further research is needed on the risks and benefits of supplementary iodine for both maternal thyroid function and child neurodevelopment.
authors.forename: Marisa
authors.initials: M
authors.lastname: Rebagliato
authors.forename: Mario
authors.initials: M
authors.lastname: Murcia
authors.forename: Mar
authors.initials: M
authors.lastname: Alvarez-Pedrerol
authors.forename: Mercedes
authors.initials: M
authors.lastname: Espada
authors.forename: Ana
authors.initials: A
authors.lastname: Fernández-Somoano
authors.forename: Nerea
authors.initials: N
authors.lastname: Lertxundi
authors.forename: Eva-María
authors.initials: EM
authors.lastname: Navarrete-Muñoz
authors.forename: Joan
authors.initials: J
authors.lastname: Forns
authors.forename: Aritz
authors.initials: A
authors.lastname: Aranbarri
authors.forename: Sabrina
authors.initials: S
authors.lastname: Llop
authors.forename: Jordi
authors.initials: J
authors.lastname: Julvez
authors.forename: Adonina
authors.initials: A
authors.lastname: Tardón
authors.forename: Ferran
authors.initials: F
authors.lastname: Ballester
mesh_terms: D002657:Child Development / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D015331:Cohort Studies; D004032:Diet / Q000706:statistics & numerical data; D019587:Dietary Supplements / Q000009:adverse effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005504:Food Analysis; D006801:Humans; D007223:Infant; D007407:Interviews as Topic; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects* / Q000652:urine; D016015:Logistic Models; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D015337:Multicenter Studies as Topic; D015999:Multivariate Analysis; D011247:Pregnancy; D011597:Psychomotor Performance / Q000187:drug effects*; D013030:Spain
chemical_list: D007455:Iodine
keywords: child development; dietary supplements; fetal development; iodine; prenatal nutritional physiological phenomena