title: Compared with DBA/2J mice, C57BL/6J mice demonstrate greater preference for saccharin and less avoidance of a cocaine-paired saccharin cue.
abstract: Rats avoid intake of a saccharin cue when paired with a drug of abuse. While this is true for most subjects, the degree of avoidance of the drug-paired cue depends upon many factors including an individual rat's preference for rewards. That said, the direction of this effect is complex. For example, reward-preferring Lewis rats exhibit greater cocaine-induced avoidance of a saccharin cue relative to Fischer 344 rats; while reward-preferring mice that overexpress ΔFosB (NSE-tTA × TetOp-ΔFosB) exhibit less avoidance of the drug-paired taste cue compared to controls. The aim here was to use two strains of commonly used mice, C57BL/6J and DBA/2J, to determine whether known differences in sensitivity to rewards will facilitate or attenuate drug-induced suppression of intake of a drug-paired taste cue. The results of Experiment 1 demonstrate that C57BL/6J mice, compared with DBA/2J mice, exhibit attenuated suppression of saccharin intake when it is paired with cocaine. The results of Experiment 2 demonstrate that strain differences in impulsivity are not likely to account for these differences. It is proposed that, while the C57BL/6J mice typically are more responsive to drug, they also are more responsive to natural rewards (in this case saccharin), and the stronger preference for saccharin serves to militate against drug.
authors.affiliation: Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. csf5@psu.edu
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Freet
authors.forename: Amanda
authors.initials: A
authors.lastname: Arndt
authors.forename: Patricia S
authors.initials: PS
authors.lastname: Grigson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002755:Choice Behavior / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage*; D003463:Cues; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage*; D004326:Drinking / Q000187:drug effects; D005518:Food Preferences / Q000187:drug effects*; D007175:Impulsive Behavior / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012439:Saccharin / Q000008:administration & dosage*; D013045:Species Specificity; D013549:Sweetening Agents / Q000008:administration & dosage*
chemical_list: D018765:Dopamine Uptake Inhibitors; D013549:Sweetening Agents; D012439:Saccharin; D003042:Cocaine
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