title: Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer.
abstract: OBJECTIVE
  The study aims to assess the feasibility of tomotherapy-based image-guided (IGRT) radiotherapy for locally advanced oropharyngeal cancer. A retrospective review of 33 patients undergoing concurrent chemoradiation for locally advanced oropharyngeal cancers was conducted. Radiotherapy planning, treatment toxicity and loco-regional control were assessed.
  
  
  RESULTS
  At a median follow-up of 32 months (6-47 months), no patient developed loco-regional recurrence. Two patients (6%) developed distant metastases. Grade 3-4 acute toxicity was respectively 72% and 25% for mucositis and gastrointestinal toxicity. Two patients (6%) had long-term dependence on tube feedings. Dose-volume histogram demonstrated excellent target volume coverage and low radiation dose to the organs at risk for complications.
  
  
  CONCLUSIONS
  IGRT provides excellent loco-regional control but acute toxicity remains significant and needs to be addressed in future prospective trials. The feasibility of Tomotherapy to decrease radiation dose to the normal tissues merits further investigations.
authors.affiliation: Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA. NamPhong.Nguyen@yahoo.com
authors.forename: Nam P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: Misty
authors.initials: M
authors.lastname: Ceizyk
authors.forename: Paul
authors.initials: P
authors.lastname: Vos
authors.forename: Michael
authors.initials: M
authors.lastname: Betz
authors.forename: Alexander
authors.initials: A
authors.lastname: Chi
authors.forename: Fabio
authors.initials: F
authors.lastname: Almeida
authors.forename: Rick
authors.initials: R
authors.lastname: Davis
authors.forename: Benjamin
authors.initials: B
authors.lastname: Slane
authors.forename: Steven
authors.initials: S
authors.lastname: Gelumbauskas
authors.forename: Lexie
authors.initials: L
authors.lastname: Smith-Raymond
authors.forename: Dave
authors.initials: D
authors.lastname: Abraham
authors.forename: Michelle
authors.initials: M
authors.lastname: Stevie
authors.forename: Siyoung
authors.initials: S
authors.lastname: Jang
authors.forename: Vincent
authors.initials: V
authors.lastname: Vinh-Hung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy / Q000628:therapy*; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
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