title: (3R,4S,5R,6R,7S)-3,4,5,7-Tetrahydroxyconidine, an azetidine analogue of 6,7-diepicastanospermine and a conformationally constrained d-deoxyaltronojirimycin, from l-arabinose.
abstract: The synthesis from l-arabinose of an azetidine analogue of 6,7-diepicastanospermine and its glycosidase inhibition profile are described.
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: R Fernando
authors.initials: RF
authors.lastname: Martínez
authors.forename: Noelia
authors.initials: N
authors.lastname: Araújo
authors.forename: Sarah F
authors.initials: SF
authors.lastname: Jenkinson
authors.forename: Shinpei
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kato
authors.forename: George W J
authors.initials: GW
authors.lastname: Fleet
mesh_terms: D017485:1-Deoxynojirimycin / Q000737:chemistry*; D001089:Arabinose / Q000737:chemistry*; D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism; D007212:Indolizines / Q000737:chemistry*; D008968:Molecular Conformation; D011485:Protein Binding; D013237:Stereoisomerism; D054836:Indolizidines
chemical_list: D017485:1-Deoxynojirimycin; D001089:Arabinose; D001384:Azetidines; D004791:Enzyme Inhibitors; D006026:Glycoside Hydrolases; D007212:Indolizines; C586294:3,4,5,7-tetrahydroxyconidine; C082735:azetidine; C037806:castanospermine; D054836:Indolizidines
keywords: 6,7-Diepicastanospermine; Azetidine; Glycosidase inhibition; l-Arabinose