title: Gastric cancer stem cells: therapeutic targets.
abstract: During the past decade, a growing body of evidence has implied that cancer stem cells (CSCs) play an important role in the development of gastric cancer (GC). The notion that CSCs give rise to GC and may be responsible for invasion, metastasis, and resistance to treatment has profound implications for anti-cancer therapy. Recent major advances in the rapidly evolving field of CSCs have opened novel exciting opportunities for developing CSC-targeted therapies. Discovery of specific markers and signaling pathways in gastric CSCs (GCSCs), with the perfecting of technologies for identification, isolation, and validation of CSCs, may provide the basis for a revolutionary cancer treatment approach based on the eradication of GCSCs. Emerging therapeutic tools based on specific properties and functions of CSCs, including activation of self-renewal signaling pathways, differences in gene expression profiles, and increased activity of telomerase or chemoresistance mechanisms, are developing in parallel with advances in nanotechnology and bioengineering. The addition of GCSC-targeted therapies to current oncological protocols and their complementary application may be the key to successfully fighting GC.
authors.affiliation: Faculty of Medicine, Institute of Pathology, University of Nis, Zorana Djindjica Blvd 81, 18000, Nis, Serbia, slavicastojnev@gmail.com.
authors.forename: Slavica
authors.initials: S
authors.lastname: Stojnev
authors.forename: Miljan
authors.initials: M
authors.lastname: Krstic
authors.forename: Ana
authors.initials: A
authors.lastname: Ristic-Petrovic
authors.forename: Vladisav
authors.initials: V
authors.lastname: Stefanovic
authors.forename: Takanori
authors.initials: T
authors.lastname: Hattori
mesh_terms: D004337:Drug Carriers; D058750:Epithelial-Mesenchymal Transition; D015316:Genetic Therapy / Q000379:methods; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology*; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D060449:Wnt Signaling Pathway
chemical_list: D004337:Drug Carriers; D053823:Hedgehog Proteins; D051880:Receptors, Notch
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