title: A population-based comparison of overall and disease-specific survival following local excision or abdominoperineal resection for stage I rectal adenocarcinoma.
abstract: OBJECTIVE
  The use of local excision (LE) for early stage rectal adenocarcinoma is increasing due to the associated morbidity of radical resection. To determine if survival in stage I rectal cancer differs following LE or abdominoperineal resection (APR), we analyzed the Surveillance, Epidemiology, and End Results Database.
  
  
  METHODS
  We selected patients diagnosed between 1988 and 2002 with T1-2N0M0 rectal adenocarcinoma measuring ≤4 cm who underwent either local excision with (LE + RT) or without adjuvant radiation (LE alone) or APR alone. Overall survival (OS) and disease-specific survival (DSS) curves were calculated using the Kaplan-Meier method. Univariate and multivariate Cox regression was also performed to determine the effect of covariates on OS and DSS.
  
  
  RESULTS
  A total of 2,391 patients were identified including 981 (41 %) treated with APR, 1,018 (43 %) treated with LE alone, and 392 (16 %) treated with LE + RT. With a median follow-up of 69 months, there was no difference in OS or DSS seen between the three groups (p > 0.05 for all comparisons). When stratifying by T-stage, there was a significant difference in overall survival between LE alone and APR for T2 disease. However, there was no difference in DSS between these two subgroups. There were no other significant survival differences between all comparable subgroups.
  
  
  CONCLUSIONS
  In this large population-based study, there was no difference in long-term DSS between patients who underwent an APR compared to selected patients who underwent LE with or without adjuvant radiation. Although these data further reinforce the promising data regarding the selected use of LE, further prospective studies are needed to further elucidate the role of LE in this setting.
authors.affiliation: Department of Veterans Affairs, New York Harbor Healthcare System, New York, NY 11209, USA. michelle.olsheski@gmail.com
authors.forename: Michelle
authors.initials: M
authors.lastname: Olsheski
authors.forename: David
authors.initials: D
authors.lastname: Schwartz
authors.forename: Justin
authors.initials: J
authors.lastname: Rineer
authors.forename: Angela
authors.initials: A
authors.lastname: Wortham
authors.forename: Sonal
authors.initials: S
authors.lastname: Sura
authors.forename: Gainosuke
authors.initials: G
authors.lastname: Sugiyama
authors.forename: Marvin
authors.initials: M
authors.lastname: Rotman
authors.forename: David
authors.initials: D
authors.lastname: Schreiber
mesh_terms: D000005:Abdomen / Q000473:pathology / Q000601:surgery*; D000230:Adenocarcinoma / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D013505:Digestive System Surgical Procedures / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010502:Perineum / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D055815:Young Adult
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