title: Cyclohexanone derivatives with cytotoxicity from the fungus Penicillium commune.
abstract: Four new cyclohexanone derivatives (2-5) and one known analog, (-)-Palitantin (1) were isolated from the EtOAc extract of Penicillium commune, a fungal strain of low-temperature habitats. The structures of 2-5 were determined on the basis of extensive spectroscopic analysis. Furthermore, the absolute configuration of 2 was assigned by electronic circular dichroism (ECD) calculations, whereas that 3-5 were deduced via the CD data. Cytotoxicities of 2-5 against five human carcinoma cell lines (Hela, A549, MCF7, HCT116, T24) were evaluated.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Fang-zhi
authors.initials: FZ
authors.lastname: Liu
authors.forename: Jin-wei
authors.initials: JW
authors.lastname: Ren
authors.forename: Jin-shan
authors.initials: JS
authors.lastname: Tang
authors.forename: Xing-zhong
authors.initials: XZ
authors.lastname: Liu
authors.forename: Yong-sheng
authors.initials: YS
authors.lastname: Che
authors.forename: Xin-sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D003511:Cyclohexanols / Q000302:isolation & purification; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D017753:Ecosystem; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D010407:Penicillium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D003511:Cyclohexanols; D003512:Cyclohexanones; C108794:palitantin