title: Fabrication of nature-inspired microfluidic network for perfusable tissue constructs.
abstract: A microreplication method is presented to transfer nature optimized vascular network of leaf venation into various synthetic matrixes. The biomaterial hydrogel with these microfluidic networks is proven to facilitate the growth of endothelial cells and simultaneously function as convection pathways to transport nutrients and oxygen in a pump-free bioreactor setup, which is crucial for the long-term viability of encapsulated cells.
authors.affiliation: State key laboratory for manufacturing, systems engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China. jiankanghe@mail.xjtu.edu.cn.
authors.forename: Jiankang
authors.initials: J
authors.lastname: He
authors.forename: Mao
authors.initials: M
authors.lastname: Mao
authors.forename: Yaxiong
authors.initials: Y
authors.lastname: Liu
authors.forename: Jinyou
authors.initials: J
authors.lastname: Shao
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Jin
authors.forename: Dichen
authors.initials: D
authors.lastname: Li
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D042783:Endothelial Cells / Q000166:cytology; D056945:Hep G2 Cells; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C013830:baysilon; D003094:Collagen
keywords: biomaterial hydrogel; leaf venation; microfluidic network; tissue engineering