title: Maintaining photosynthetic CO2 fixation via protein remodelling: the Rubisco activases.
abstract: The key photosynthetic, CO2-fixing enzyme Rubisco forms inactivated complexes with its substrate ribulose 1,5-bisphosphate (RuBP) and other sugar phosphate inhibitors. The independently evolved AAA+ proteins Rubisco activase and CbbX harness energy from ATP hydrolysis to remodel Rubisco complexes, facilitating release of these inhibitors. Here, we discuss recent structural and mechanistic advances towards the understanding of protein-mediated Rubisco activation. Both activating proteins appear to form ring-shaped hexameric arrangements typical for AAA+ ATPases in their functional form, but display very different regulatory and biochemical properties. Considering the thermolability of the plant enzyme, an improved understanding of the mechanism for Rubisco activation may help in developing heat-resistant plants adapted to the challenge of global warming.
authors.affiliation: School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore, cajar@ntu.edu.sg.
authors.forename: Oliver
authors.initials: O
authors.lastname: Mueller-Cajar
authors.forename: Mathias
authors.initials: M
authors.lastname: Stotz
authors.forename: Andreas
authors.initials: A
authors.lastname: Bracher
mesh_terms: D001709:Biotechnology / Q000379:methods / Q000639:trends; D002245:Carbon Dioxide / Q000378:metabolism*; D010788:Photosynthesis / Q000502:physiology*; D010940:Plant Proteins / Q000737:chemistry* / Q000378:metabolism*; D011487:Protein Conformation; D013403:Sugar Phosphates / Q000378:metabolism; D013696:Temperature
chemical_list: D010940:Plant Proteins; D013403:Sugar Phosphates; C054765:rca protein, plant; D002245:Carbon Dioxide
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