title: Associations between visit-to-visit variability in blood pressure measured in the office and antihypertensive drugs: the J-HOME-Morning study.
abstract: The factors associated with visit-to-visit variability in blood pressure (BP) measured in the office between the two visits were identified in 1379 treated hypertensive patients (mean age, 66.1 ± 11.0 y; women, 53.8%). Multivariate regression analysis showed that office BP and visit-to-visit heart rate variability were positively associated with visit-to-visit BP variability, whereas body mass index, duration of antihypertensive medication, and taking amlodipine were negatively associated with visit-to-visit BP variability. Further prospective studies are required to clarify the causal relationships between these factors and visit-to-visit BP variability among treated hypertensive patients.
authors.affiliation: Division of Molecular Epidemiology, Tohoku University Graduate School of Medicine, Sendai, Japan. obara-t@hosp.tohoku.ac.jp
authors.forename: Taku
authors.initials: T
authors.lastname: Obara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuya
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Kazuki
authors.initials: K
authors.lastname: Ishikura
authors.forename: Urara
authors.initials: U
authors.lastname: Ikeda
authors.forename: Mami
authors.initials: M
authors.lastname: Ishikuro
authors.forename: Hirohito
authors.initials: H
authors.lastname: Metoki
authors.forename: Nariyasu
authors.initials: N
authors.lastname: Mano
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kuriyama
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Imai
mesh_terms: D000368:Aged; D017311:Amlodipine / Q000627:therapeutic use; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002940:Circadian Rhythm; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009819:Office Visits; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D017311:Amlodipine