title: Fully automated on-screen carotid intima-media thickness measurement: a screening tool for subclinical atherosclerosis.
abstract: OBJECTIVE
  Carotid intima-media thickness (CIMT) is generally considered an appropriate direct vascular method for cardiovascular risk assessment. The objective of this study was to evaluate the feasibility and reproducibility of a newly developed automated on-screen carotid ultrasound with respect to manual measurement with a conventional system.
  
  
  METHODS
  We assessed CIMT in 50 consecutive patients (age 62 ± 5 years, range 21-79 years, 36 men) twice, using a newly developed automated ultrasound (CardioHealth Station) and a conventional system with manual measurement (Acuson, Sequoia). For each patient, three frozen frames of the distal 10 mm of the right and left common carotid arteries were acquired on the two systems, by operators blinded to each other. The average of the mean value of three readings of each system was calculated.
  
  
  RESULTS
  The intraclass correlation coefficient of the interoperator variability was 0.95 and 0.94 for the automated and manual measurements, respectively. The comparative coefficient of variation of the interoperator variability was 8.2 and 8.7% for the automated and manual measurements, respectively. There was no clinically relevant difference between measurements obtained by the two systems (intraclass correlation coefficient = 0.98). The acquisition time of the automated system was significantly shorter than the conventional system (p < 0.01).
  
  
  CONCLUSIONS
  Fully automated on-screen measurements of CIMT are feasible, faster, and as reproducible as conventional manual measurements and may be suitable and cost-effective for screening application in community medicine.
authors.affiliation: Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
authors.forename: Davide
authors.initials: D
authors.lastname: Vanoli
authors.forename: Per
authors.initials: P
authors.lastname: Lindqvist
authors.forename: Urban
authors.initials: U
authors.lastname: Wiklund
authors.forename: Michael
authors.initials: M
authors.lastname: Henein
authors.forename: Ulf
authors.initials: U
authors.lastname: Näslund
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058070:Asymptomatic Diseases; D050197:Atherosclerosis / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness / Q000295:instrumentation*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results