title: Advantages of recombinant follicle-stimulating hormone over human menopausal gonadotropin for ovarian stimulation in intrauterine insemination: a randomized clinical trial in unexplained infertility.
abstract: OBJECTIVE
  To compare two different gonadotropin preparations, human menopausal gonadotropin (hMG) and recombinant follicle-stimulating hormone (rFSH), combined with clomiphene citrate (CC) in women with unexplained infertility undergoing intrauterine insemination (IUI).
  
  
  METHODS
  In this prospective clinical trial, couples prepared for IUI cycles were randomly allocated to two groups either to receive CC and hMG (group A, n=127) or CC and rFSH (group B, n=132) for ovarian stimulation. Outcomes including rates of clinical pregnancy, miscarriage, OHSS, multiple pregnancy, cancellation, and live birth were compared between groups.
  
  
  RESULTS
  Duration of gonadotropin therapy was significantly shorter in group B (5.1±0.84 vs. 4.7±0.8 days, CI=95%, P<0.001). The total dose of administered gonadotropin was also significantly lower in group B (386.9±68.2 vs. 348.2±56.3IU, CI=95%, P<0.001). Dominant follicle number (>17mm), mean follicular diameter, and endometrial thickness on the day of hCG injection were similar. Clinical pregnancy, multiple pregnancies, abortion, live birth, ovarian hyperstimulation syndrome (OHSS), and cancellation rates were not statistically different between the groups.
  
  
  CONCLUSIONS
  IUI cycles in which rFSH had been administered may require shorter duration and a lower total gonadotropin dose.
authors.affiliation: Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mandana
authors.initials: M
authors.lastname: Rashidi
authors.forename: Ashraf
authors.initials: A
authors.lastname: Aaleyasin
authors.forename: Marzieh
authors.initials: M
authors.lastname: Aghahosseini
authors.forename: Shohre
authors.initials: S
authors.lastname: Loloi
authors.forename: Abas
authors.initials: A
authors.lastname: Kokab
authors.forename: Zahra
authors.initials: Z
authors.lastname: Najmi
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D007317:Insemination, Artificial, Homologous; D008297:Male; D008596:Menotropins / Q000008:administration & dosage*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D005300:Fertility Agents, Female; D011994:Recombinant Proteins; D002996:Clomiphene; D008596:Menotropins; D005640:Follicle Stimulating Hormone
keywords: Human menopausal gonadotropin; Intrauterine insemination; Recombinant follicle-stimulating hormone; Unexplained infertility