title: Association between age at diagnosis of Graves' disease and variants in genes involved in immune response.
abstract: BACKGROUND
  Graves' disease (GD) is a complex disease in which genetic predisposition is modified by environmental factors. The aim of the study was to examine the association between genetic variants in genes encoding proteins involved in immune response and the age at diagnosis of GD.
  
  
  METHODS
  735 GD patients and 1216 healthy controls from Poland were included into the study. Eight genetic variants in the HLA-DRB1, TNF, CTLA4, CD40, NFKb, PTPN22, IL4 and IL10 genes were genotyped. Patients were stratified by the age at diagnosis of GD and the association with genotype was analysed.
  
  
  RESULTS
  Polymorphism in the HLA-DRB1, TNF and CTLA4 genes were associated with GD. The carriers of the HLA DRB1*03 allele were more frequent in patients with age at GD diagnosis ≤30 years than in patients with older age at GD diagnosis.
  
  
  CONCLUSIONS
  HLADRB1*03 allele is associated with young age at diagnosis of Graves' disease in Polish population.
authors.affiliation: Department of Nuclear, Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer, Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Jurecka-Lubieniecka
authors.forename: Rafal
authors.initials: R
authors.lastname: Ploski
authors.forename: Dorota
authors.initials: D
authors.lastname: Kula
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Krol
authors.forename: Tomasz
authors.initials: T
authors.lastname: Bednarczuk
authors.forename: Zofia
authors.initials: Z
authors.lastname: Kolosza
authors.forename: Andrzej
authors.initials: A
authors.lastname: Tukiendorf
authors.forename: Sylwia
authors.initials: S
authors.lastname: Szpak-Ulczok
authors.forename: Anita
authors.initials: A
authors.lastname: Stanjek-Cichoracka
authors.forename: Joanna
authors.initials: J
authors.lastname: Polanska
authors.forename: Barbara
authors.initials: B
authors.lastname: Jarzab
mesh_terms: D000328:Adult; D000367:Age Factors; D060908:CTLA-4 Antigen / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology*; D049970:Graves Ophthalmopathy / Q000175:diagnosis / Q000235:genetics; D059811:HLA-DRB1 Chains / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007109:Immunity / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D060908:CTLA-4 Antigen; D059811:HLA-DRB1 Chains; D014409:Tumor Necrosis Factor-alpha
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