title: Enantiocomplementary access to carba-analogs of C-nucleoside derivatives by recombinant Baeyer-Villiger monooxygenases.
abstract: A novel and stereoselective synthetic route towards carba-C-nucleosides was investigated applying an enantiodivergent biooxidation strategy by two different Baeyer-Villiger monooxygenases. Within only three chemo-enzymatic steps it was possible to introduce four chiral centers starting from commercially available non-chiral starting material.
authors.affiliation: Instituto de Química Rosario (IQUIR, CONICET-UNR) and Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina.
authors.forename: Dario A
authors.initials: DA
authors.lastname: Bianchi
authors.forename: Roberto
authors.initials: R
authors.lastname: Moran-Ramallal
authors.forename: Naseem
authors.initials: N
authors.lastname: Iqbal
authors.forename: Florian
authors.initials: F
authors.lastname: Rudroff
authors.forename: Marko D
authors.initials: MD
authors.lastname: Mihovilovic
mesh_terms: D054329:Carbasugars / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D006899:Mixed Function Oxygenases / Q000235:genetics / Q000378:metabolism*; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D009993:Osmium Tetroxide / Q000737:chemistry; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics; D013237:Stereoisomerism
chemical_list: D054329:Carbasugars; D007659:Ketones; D009705:Nucleosides; D011994:Recombinant Proteins; D006899:Mixed Function Oxygenases; D009993:Osmium Tetroxide