title: Antioxidant and anticancer activities of Chenopodium quinoa leaves extracts - in vitro study.
abstract: The nutraceutical potential of Chenopodium quinoa Leaves (ChL) was assessed through analyses of their phenolic content, elucidation of the effect of ChL phenolic compounds on cancer cell properties and estimation of their antioxidative activity, bioaccessibility and bioavailability in vitro. Considerable amounts of ferulic, sinapinic and gallic acids, kaempferol, isorhamnetin and rutin were observed in the chemical ChL extract and were linked with its inhibitory effect on prostate cancer cell proliferation, motility and cellular competence for gap junctional communication. Both extracts, chemical and obtained after simulated digestion, exerted an inhibitory effect on lipoxygenase activity, paralleled by their considerable chelating, antioxidative, antiradical and reducing power. These observations indicate that phenolic ChL compounds may exert a chemopreventive and anticarcinogenic effect on oxidative stress and ROS-dependent intracellular signaling via synergic effects. The relatively high potential bioaccessibility and bioavailability of the compounds probably responsible for these effects demonstrates the suitability of ChL for dietary supplementation.
authors.affiliation: Department of Biochemistry and Food Chemistry, University of Life Sciences, Skromna Str. 8, 20-704 Lublin, Poland. urszula.gawlik@up.lublin.pl
authors.forename: Urszula
authors.initials: U
authors.lastname: Gawlik-Dziki
authors.forename: Michał
authors.initials: M
authors.lastname: Świeca
authors.forename: Maciej
authors.initials: M
authors.lastname: Sułkowski
authors.forename: Dariusz
authors.initials: D
authors.lastname: Dziki
authors.forename: Barbara
authors.initials: B
authors.lastname: Baraniak
authors.forename: Jarosław
authors.initials: J
authors.lastname: Czyż
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001682:Biological Availability; D045744:Cell Line, Tumor; D027465:Chenopodium quinoa / Q000737:chemistry*; D019587:Dietary Supplements; D004354:Drug Screening Assays, Antitumor; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000032:analysis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D010636:Phenols; D010936:Plant Extracts; D017382:Reactive Oxygen Species