title: 03219A, a new Δ(8,9)-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment.
abstract: 03219A (1), a new pregnene steroid possessing a rare Δ(8,9)-double bond in the skeleton, together with the known naphthoquinone antibiotic (+)-cryptosporin (2) have been isolated from the fermentation broth of Streptomyces sp. SCSIO 03219, which was isolated from a marine sediment collected in the South China Sea. The structure of 03219A was elucidated using a combination of NMR, MS and X-ray crystallographic methods.
authors.affiliation: CAS Key Laboratory of Marine Bio-Resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhou
authors.forename: Hongbo
authors.initials: H
authors.lastname: Huang
authors.forename: Xinpeng
authors.initials: X
authors.lastname: Tian
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Song
authors.forename: Si
authors.initials: S
authors.lastname: Zhang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ju
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002681:China; D018360:Crystallography, X-Ray; D052978:Disk Diffusion Antimicrobial Tests; D005285:Fermentation; D019015:Geologic Sediments / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification; D009792:Oceans and Seas; D010802:Phylogeny; D011283:Pregnenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; D011283:Pregnenes; C007161:cryptosporin