title: Mediating lipid biosynthesis: implications for cardiovascular disease.
abstract: Dysregulation of lipid homeostasis is a risk factor for cardiovascular disease (CVD). Thus, understanding the molecular mechanisms of maintaining lipid homeostasis may aid the discovery of novel targets for treating CVD. MED15 and cyclin-dependent kinase-8 (CDK8) are subunits of the Mediator complex, which contains multiple proteins and functions as a transcriptional cofactor. Mediator can positively or negatively regulate gene expression, depending on the contexts and its associated transcription factors. Recent studies revealed a critical role of MED15 and CDK8 in regulating sterol regulatory element-binding protein (SREBP) transcription factors, which are master activators for genes that are responsible for lipid biosynthesis. Here, we review the function of MED15 and CDK8 in regulating lipid homeostasis and discuss the implications for CVD.
authors.affiliation: Department of Medicine and Developmental & Molecular Biology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461.
authors.lastname: Xiaoli
authors.forename: Fajun
authors.initials: F
authors.lastname: Yang
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism*; D056850:Cyclin-Dependent Kinase 8 / Q000235:genetics*; D055808:Drug Discovery; D005786:Gene Expression Regulation; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D056892:Mediator Complex / Q000235:genetics; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics*; D013261:Sterols / Q000096:biosynthesis*; D014157:Transcription Factors
chemical_list: C416944:MED15 protein, human; D056892:Mediator Complex; D051780:Sterol Regulatory Element Binding Protein 1; D013261:Sterols; D014157:Transcription Factors; D056850:Cyclin-Dependent Kinase 8
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