title: Right ventricular failure in congenital heart disease.
abstract: Despite developments in surgical techniques and other interventions, right ventricular (RV) failure remains an important clinical problem in several congenital heart diseases (CHD). RV function is one of the most important predictors of mortality and morbidity in patients with CHD. RV failure is a progressive disorder that begins with myocardial injury or stress, neurohormonal activation, cytokine activation, altered gene expression, and ventricular remodeling. Pressure-overload RV failure caused by RV outflow tract obstruction after total correction of tetralogy of Fallot, pulmonary stenosis, atrial switch operation for transposition of the great arteries, congenitally corrected transposition of the great arteries, and systemic RV failure after the Fontan operation. Volume-overload RV failure may be caused by atrial septal defect, pulmonary regurgitation, or tricuspid regurgitation. Although the measurement of RV function is difficult because of many reasons, the right ventricle can be evaluated using both imaging and functional modalities. In clinical practice, echocardiography is the primary mode for the evaluation of RV structure and function. Cardiac magnetic resonance imaging is increasingly used for evaluating RV structure and function. A comprehensive evaluation of RV function may lead to early and optimal management of RV failure in patients with CHD.
authors.affiliation: Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Young Kuk
authors.initials: YK
authors.lastname: Cho
authors.forename: Jae Sook
authors.initials: JS
authors.lastname: Ma
keywords: Congenital heart disease; Right ventricle; Right-side heart failure
references.citation: Chest. 2004 Jul;126(1 Suppl):35S-62S
references.pmid: 15249494
references.citation: Am J Cardiol. 2006 Apr 1;97(7):1051-5
references.pmid: 16563914
references.citation: Am J Cardiol. 1998 Jan 15;81(2):247-50
references.pmid: 9591916
references.citation: Circulation. 1985 Mar;71(3):473-80
references.pmid: 2578902
references.citation: Am J Respir Crit Care Med. 1994 Sep;150(3):833-52
references.pmid: 8087359
references.citation: Circulation. 2006 Oct 24;114(17):1883-91
references.pmid: 17060398
references.citation: Prog Cardiovasc Dis. 1998 Jan-Feb;40(4):289-308
references.pmid: 9449956
references.citation: Am J Cardiol. 1990 Mar 15;65(11):736-41
references.pmid: 1690502
references.citation: Circulation. 1990 Aug;82(2):359-68
references.pmid: 2372887
references.citation: Heart. 2006 Apr;92 Suppl 1:i27-38
references.pmid: 16543599
references.citation: Circulation. 1995 Mar 15;91(6):1782-9
references.pmid: 7882488
references.citation: Circulation. 1995 Mar 15;91(6):1775-81
references.pmid: 7882487
references.citation: Circulation. 1991 Dec;84(6):2259-74
references.pmid: 1959181
references.citation: Clin Chest Med. 2007 Mar;28(1):243-53, x
references.pmid: 17338939
references.citation: Eur J Cardiothorac Surg. 2004 Oct;26(4):776-81
references.pmid: 15450572
references.citation: J Am Coll Cardiol. 1986 Apr;7(4):800-6
references.pmid: 3958336
references.citation: Circulation. 2005 Apr 26;111(16):2091-8
references.pmid: 15851616
references.citation: Am J Physiol. 1985 Aug;249(2 Pt 2):H371-9
references.pmid: 3161346
references.citation: Circulation. 2006 Oct 10;114(15):1645-53
references.pmid: 17030704
references.citation: J Am Soc Echocardiogr. 2007 Sep;20(9):1065-72
references.pmid: 17566702
references.citation: Circulation. 2004 Apr 6;109(13):1580-9
references.pmid: 15066961
references.citation: J Thorac Cardiovasc Surg. 1995 Apr;109(4):642-52; discussion 652-3
references.pmid: 7715211
references.citation: Circulation. 2006 Sep 26;114(13):1417-31
references.pmid: 17000921
references.citation: Circulation. 2006 Dec 12;114(24):2699-709
references.pmid: 17159076
references.citation: Curr Probl Cardiol. 1991 Oct;16(10):653-720
references.pmid: 1748012
references.citation: J Am Coll Cardiol. 2000 May;35(6):1661-8
references.pmid: 10807474
references.citation: Heart. 2006 Apr;92 Suppl 1:i2-13
references.pmid: 16543598
references.citation: Anesth Analg. 2009 Feb;108(2):407-21
references.pmid: 19151264
references.citation: J Cardiovasc Magn Reson. 2005;7(2):501-16
references.pmid: 15881535
references.citation: Circulation. 1987 Nov;76(5):1037-42
references.pmid: 3664992
references.citation: Chest. 2004 Oct;126(4):1330-6
references.pmid: 15486400
references.citation: J Cardiovasc Magn Reson. 1999;1(1):7-21
references.pmid: 11550343
references.citation: Circulation. 1982 Jun;65(7):1374-81
references.pmid: 6280890
references.citation: J Thorac Cardiovasc Surg. 2004 Aug;128(2):296-302
references.pmid: 15282468
references.citation: Circulation. 1996 Apr 15;93(8):1509-14
references.pmid: 8608618
references.citation: Circulation. 2003 Aug 19;108(7):844-8
references.pmid: 12900346
references.citation: Circulation. 2002 Jun 11;105(23):2701-3
references.pmid: 12057980
references.citation: J Am Coll Cardiol. 2005 Dec 20;46(12):2277-83
references.pmid: 16360058
references.citation: Circulation. 2008 Apr 1;117(13):1717-31
references.pmid: 18378625
references.citation: Circulation. 2005 Oct 18;112(16):2411-6
references.pmid: 16216961
references.citation: J Am Coll Cardiol. 2004 Aug 18;44(4):793-8
references.pmid: 15312861
references.citation: Circulation. 2002 Sep 3;106(10):1263-8
references.pmid: 12208803
references.citation: Circulation. 2008 Mar 18;117(11):1436-48
references.pmid: 18347220
references.citation: Am J Cardiol. 2005 Mar 15;95(6):779-82
references.pmid: 15757612
references.citation: Am Heart J. 2003 Feb;145(2):310-6
references.pmid: 12595849
references.citation: Coron Artery Dis. 2005 Feb;16(1):13-8
references.pmid: 15654194
references.citation: Crit Care. 2001 Dec;5(6):355-61
references.pmid: 11737925
references.citation: Physiol Res. 1991;40(1):31-7
references.pmid: 1931916