title: In vitro and in vivo experimental models as tools to investigate the efficacy of antineoplastic drugs on urinary bladder cancer.
abstract: Several drugs have shown in vitro and in vivo pharmacological activity against urinary bladder cancer. This review aims at compiling the different drugs evaluated in in vitro and in vivo models of urinary bladder cancer and to review the advantages and limitations of both types of models, as well as the different methodologies applied for evaluating antineoplastic drug activity.
authors.affiliation: Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Regina
authors.initials: R
authors.lastname: Arantes-Rodrigues
authors.forename: Aura
authors.initials: A
authors.lastname: Colaço
authors.forename: Rosário
authors.initials: R
authors.lastname: Pinto-Leite
authors.forename: Paula A
authors.initials: PA
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004195:Disease Models, Animal; D006801:Humans; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents