title: Trivalent ion cross-linked pH sensitive alginate-methyl cellulose blend hydrogel beads from aqueous template.
abstract: pH sensitive alginate-methyl cellulose blend hydrogel beads were prepared by single water-in-water (w/w) emulsion gelation method in a complete aqueous environment. The influence of different variables like total polymer concentration, gelation time and crosslinker content on in vitro physico-chemical characteristics and drug release rate in different medium were investigated. Drug loaded beads were evaluated through Fourier Transform Infra-red (FTIR), X-ray diffraction (XRD) and Differential Scanning Calorimetry (DSC) analysis. Scanning electron microscopy (SEM) picture of the dried beads suggested the formation of hemispherical particles. FTIR analysis indicated the stable nature of the drug in the blend hydrogel beads. DSC and XRD analysis revealed amorphous state of drug after encapsulation. The drug release profile in acidic medium was considerably less in compared in alkaline media. Formulations showed non-Fickian type transport mechanism. This trivalent ion crosslinked beads not only improves drug encapsulation efficiency but also enhances drug release in alkaline media.
authors.affiliation: Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur 784 001, Assam, India. banerjee.subham@yahoo.co.in
authors.forename: Subham
authors.initials: S
authors.lastname: Banerjee
authors.forename: Shivangi
authors.initials: S
authors.lastname: Singh
authors.forename: Shiv Sankar
authors.initials: SS
authors.lastname: Bhattacharya
authors.forename: Pronobesh
authors.initials: P
authors.lastname: Chattopadhyay
mesh_terms: D000464:Alginates / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D020723:Glucuronic Acid / Q000737:chemistry / Q000493:pharmacokinetics; D006603:Hexuronic Acids / Q000737:chemistry / Q000493:pharmacokinetics; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D008747:Methylcellulose / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D020100:Hydrogels; D020723:Glucuronic Acid; D008747:Methylcellulose