title: Reduced work capacity in individuals with Down syndrome: a consequence of autonomic dysfunction?
abstract: Low work capacity and V˙O2peak commonly are described phenomena in Down syndrome. This is accompanied by chronotropic incompetence and a high incidence of obesity. Although many causes of low work capacity in Down syndrome have been proposed, little scientific support exists. Our working hypothesis is that autonomic dysfunction is the major contributor to the low levels of work capacity in this population.
authors.affiliation: 1Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA. fernhall@uic.edu
authors.forename: Bo
authors.initials: B
authors.lastname: Fernhall
authors.forename: Goncalo V
authors.initials: GV
authors.lastname: Mendonca
authors.forename: Tracy
authors.initials: T
authors.lastname: Baynard
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology*; D004314:Down Syndrome / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D010101:Oxygen Consumption; D010809:Physical Fitness / Q000502:physiology*; D014938:Work Capacity Evaluation