title: [Intraabdominal desmoid tumors in familial adenomatous polyposis].
abstract: Desmoid tumors are currently the main cause of morbidity and mortality in patients with familial adenomatous polyposis. More than 10% of these patients will develop these tumors during their lifetime and more than a third will suffer their consequences. The main risk factors for their development are female sex and abdominal surgery. The most frequent localization is intraabdominal. The therapeutic approach to these tumors has changed, and the surgical treatment of choice is currently the subject of debate. If a watch and wait approach is adopted, more than 50% of tumors will prove to be indolent. Therefore, the therapeutic strategy should be based on clinical presentation and should be decided by a multidisciplinary team working in a center with experience of these tumors. The present article proposes a prognostic classification to guide the therapeutic approach.
authors.affiliation: Servicio de Gastroenterología, Hospital Clínic, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), IDIBAPS, Universidad de Barcelona, Barcelona, España.
authors.forename: Paula
authors.initials: P
authors.lastname: Galletto
authors.forename: Maria Liz
authors.initials: ML
authors.lastname: Leoz
authors.forename: Antoni
authors.initials: A
authors.lastname: Castells
authors.forename: Francesc
authors.initials: F
authors.lastname: Balaguer
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D000328:Adult; D017668:Age of Onset; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D018222:Desmoid Tumors / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D017491:Genes, APC; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D009367:Neoplasm Staging; D017354:Point Mutation; D011379:Prognosis; D012307:Risk Factors; D017678:Sex Distribution; D057832:Watchful Waiting; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000235:genetics / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C495270:CTNNB1 protein, human; D051176:beta Catenin
keywords: Aggresive fibromatosis; Colorectal cancer; Cáncer colorrectal; Desmoid tumor; Familial adenomatous polyposis; Fibromatosis agresiva; Poliposis adenomatosa familiar; Tumor desmoide