title: Long-term effect of bariatric surgery on liver enzymes in the Swedish Obese Subjects (SOS) study.
abstract: OBJECTIVE
  Obesity is associated with elevated serum transaminase levels and non-alcoholic fatty liver disease and weight loss is a recommended therapeutic strategy. Bariatric surgery is effective in obtaining and maintaining weight loss. Aim of the present study was to examine the long-term effects of bariatric surgery on transaminase levels in obese individuals.
  
  
  METHODS
  The Swedish Obese Subjects (SOS) study is a prospective controlled intervention study designed to compare the long-term effects of bariatric surgery and usual care in obese subjects. A total of 3,570 obese participants with no excess of alcohol consumption at baseline (1,795 and 1,775 in the control and surgery group, respectively) were included in the analyses. Changes in transaminase levels during follow-up were compared in the surgery and control groups.
  
  
  RESULTS
  Compared to usual care, bariatric surgery was associated with lower serum ALT and AST levels at 2- and 10- year follow up. The reduction in ALT levels was proportional to the degree of weight loss. Both the incidence of and the remission from high transaminase levels were more favorable in the surgery group compared to the control group. Similarly, the prevalence of ALT/AST ratio <1 was lower in the surgery compared to the control group at both 2- and 10-year follow up.
  
  
  CONCLUSIONS
  Bariatric surgery results in a sustained reduction in transaminase levels and a long-term benefit in obese individuals.
authors.affiliation: Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Maria Antonella
authors.initials: MA
authors.lastname: Burza
authors.forename: Stefano
authors.initials: S
authors.lastname: Romeo
authors.forename: Anna
authors.initials: A
authors.lastname: Kotronen
authors.forename: Per-Arne
authors.initials: PA
authors.lastname: Svensson
authors.forename: Kajsa
authors.initials: K
authors.lastname: Sjöholm
authors.forename: Jarl S
authors.initials: JS
authors.lastname: Torgerson
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Lindroos
authors.forename: Lars
authors.initials: L
authors.lastname: Sjöström
authors.forename: Lena M S
authors.initials: LM
authors.lastname: Carlsson
authors.forename: Markku
authors.initials: M
authors.lastname: Peltonen
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D001835:Body Weight; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000601:surgery*; D011446:Prospective Studies; D013548:Sweden / Q000453:epidemiology; D013995:Time; D000637:Transaminases / Q000097:blood*
chemical_list: D000637:Transaminases
references.citation: Hepatology. 1999 Dec;30(6):1356-62
references.pmid: 10573511
references.citation: Gastroenterology. 2009 Aug;137(2):532-40
references.pmid: 19409898
references.citation: Clin Chem. 1975 Jul;21(8):1077-87
references.pmid: 1137913
references.citation: Hepatology. 1990 Nov;12(5):1106-10
references.pmid: 2227807
references.citation: J Clin Endocrinol Metab. 2002 Aug;87(8):3555-61
references.pmid: 12161474
references.citation: N Engl J Med. 2007 Aug 23;357(8):741-52
references.pmid: 17715408
references.citation: Gastroenterology. 2006 May;130(6):1617-24
references.pmid: 16697725
references.citation: Obes Surg. 2005 Sep;15(8):1154-60
references.pmid: 16197789
references.citation: Gastroenterology. 2005 Jul;129(1):113-21
references.pmid: 16012941
references.citation: Am J Gastroenterol. 2003 May;98(5):960-7
references.pmid: 12809815
references.citation: Hepatology. 2006 Oct;44(4):865-73
references.pmid: 17006923
references.citation: Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007340
references.pmid: 20091629
references.citation: Obes Res. 1997 Mar;5(2):105-14
references.pmid: 9112245
references.citation: Obes Surg. 2004 Oct;14(9):1227-32
references.pmid: 15527639
references.citation: Eur J Clin Nutr. 1993 Jul;47(7):461-81
references.pmid: 8404782
references.citation: Int J Obes Relat Metab Disord. 1992 Jun;16(6):465-79
references.pmid: 1322873
references.citation: Obes Surg. 2009 Dec;19(12):1664-71
references.pmid: 19526270
references.citation: N Engl J Med. 2004 Dec 23;351(26):2683-93
references.pmid: 15616203
references.citation: Obes Surg. 2007 Jul;17(7):910-9
references.pmid: 17894151
references.citation: BMC Public Health. 2010 May 10;10:237
references.pmid: 20459722
references.citation: Obes Surg. 2006 Oct;16(10):1278-86
references.pmid: 17059735
references.citation: Obes Surg. 2009 May;19(5):601-7
references.pmid: 19229660