title: Higher serum uric acid and lipoprotein(a) are correlated with coronary spasm.
abstract: It has been reported that a major cause of coronary vasospastic angina (VSA) is endothelial dysfunction of the coronary artery. On the other hand, some studies showed that serum uric acid and lipoprotein(a) are correlated with endothelial dysfunction. Thus, we examined whether uric acid and lipoprotein(a), are correlated with VSA. Four hundred forty-one patients with suspected VSA who underwent a coronary angiogram with acetylcholine provocation (ACh test) during an 8-year period were enrolled. We divided them into a VSA group, who showed coronary spasm by the ACh test, and an atypical chest pain (ACP) group, who showed negative ACh test. We compared serum markers between the two groups, including low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, high-sensitivity C-reactive protein (hs-CRP), lipoprotein(a), fibrinogen, total plasminogen activator inhibitor-1, and uric acid. Uric acid, hs-CRP, and lipoprotein(a) were significantly higher in the VSA group than in the ACP group (all P < 0.05) while there were no significant differences in the other parameters. Multivariate analyses identified uric acid and lipoprotein(a) as significant independent markers for VSA. Uric acid and lipoprotein(a) are correlated with VSA, and medical intervention to decrease uric acid and lipoprotein(a) might be effective in controlling VSA.
authors.affiliation: Division of Cardiology, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Sakai, Osaka, 591-8025, Japan, mnishino@orh.go.jp.
authors.forename: Masami
authors.initials: M
authors.lastname: Nishino
authors.forename: Naoki
authors.initials: N
authors.lastname: Mori
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakamura
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Lee
authors.forename: Masayuki
authors.initials: M
authors.lastname: Taniike
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Makino
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Kato
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Egami
authors.forename: Ryu
authors.initials: R
authors.lastname: Shutta
authors.forename: Jun
authors.initials: J
authors.lastname: Tanouchi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000109:Acetylcholine; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D003331:Coronary Vessels / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*; D014661:Vasoconstriction; D014662:Vasoconstrictor Agents
chemical_list: D015415:Biomarkers; D017270:Lipoprotein(a); D014662:Vasoconstrictor Agents; D014527:Uric Acid; D000109:Acetylcholine
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