title: Studies Toward the Synthesis of (-)-Zampanolide: Preparation of the Macrocyclic Core.
abstract: Studies towards the synthesis of the macrocyclic core of (-)-zampanolide are reported. The synthetic approach features a one-pot reduction/vinylogous aldol reaction for construction of the C15-C20 fragment, an intramolecular silyl-modified Sakurai (ISMS) reaction for construction of the 2,6-cis-disubstitutedexo-methylene pyran subunit, and use of an sp2-sp3Stille reaction for macrocyclization.
authors.affiliation: Department of Chemistry, Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA.
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Troast
authors.forename: Jiayi
authors.initials: J
authors.lastname: Yuan
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
keywords: ISMS; Stille reaction; allyl silane; exo-methylene pyran; macrolide; sp2–sp3 coupling; vinylogous aldol; zampanolide
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