title: Long-term incidence and characteristics of intestinal failure in Crohn's disease: a multicenter study.
abstract: BACKGROUND
  The aim of this study was to clarify the risk and characteristics of intestinal failure (IF) in patients with Crohn's disease (CD).
  
  
  METHODS
  The present study was a retrospective study in 12 hospitals. CD patients who underwent initial surgery at any of the 12 hospitals between 1970 and 2009 were collected (n = 1,703). Those who developed IF were reviewed (n = 68), and the cumulative risk of IF was analyzed by the Kaplan-Meier method. In addition, IF patients who underwent initial surgery at other hospitals and were then treated at any of the 12 hospitals were also reviewed (n = 33). Thus, a total of 101 IF patients were collected, and the cumulative risk of IF-related death was analyzed.
  
  
  RESULTS
  The cumulative risk of IF after the initial surgery was 0.8 % (5 years), 3.6 % (10 years), 6.1 % (15 years), and 8.5 % (20 years). In CD patients with IF, mean age at initial surgery, IF occurrence, and present age at the time of the study were 28.2, 38.2, and 46.1 years, respectively. The mean number of surgeries per patient was 3.3. The mean length of the remnant small bowel was 163 cm. Twelve IF patients (12 %) had died and the cumulative risk of IF-related death by the time from the occurrence of IF was 1.1 % (3 years), 3.7 % (5 years), 6.5 % (7 years), and 8.9 % (10 years).
  
  
  CONCLUSIONS
  The occurrence of IF and IF-related death in CD patients is not rare over the long term. There is a pressing need to develop strategies for the prevention and management of IF.
authors.affiliation: Department of Surgery, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan, k-wata@surg1.med.tohoku.ac.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Iwao
authors.initials: I
authors.lastname: Sasaki
authors.forename: Kouhei
authors.initials: K
authors.lastname: Fukushima
authors.forename: Kitaro
authors.initials: K
authors.lastname: Futami
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Sugita
authors.forename: Riichiro
authors.initials: R
authors.lastname: Nezu
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Mizushima
authors.forename: Shingo
authors.initials: S
authors.lastname: Kameoka
authors.forename: Masato
authors.initials: M
authors.lastname: Kusunoki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Funayama
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hisao
authors.initials: H
authors.lastname: Fujii
authors.forename: Mamoru
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D055499:Catheter-Related Infections / Q000209:etiology; D062905:Central Venous Catheters / Q000009:adverse effects; D003424:Crohn Disease / Q000150:complications / Q000601:surgery*; D004750:Enteral Nutrition; D005440:Fluid Therapy; D006801:Humans; D015994:Incidence; D007421:Intestine, Small; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology; D012778:Short Bowel Syndrome / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D013997:Time Factors
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