title: Methocarbamol CRI for symptomatic treatment of pyrethroid intoxication: a report of three cases.
abstract: Pyrethroids are popular for use in companion animals due to their relatively low mammalian toxicity and efficacy against arthropods. Nonetheless, pyrethroid intoxication has been reported in cats and dogs, and cats appear to be more susceptible due to difficulty in biotransformation and excretion of pyrethroids. Pyrethroid intoxications are generally due to either the improper use or accidental ingestion of approved products. Methocarbamol, given as intermittent injections, is a common first-line treatment choice for the tremors associated with pyrethroid intoxication. Two cats and one dog were treated with a methocarbamol continuous rate infusion (CRI) for pyrethroid intoxication. Clinical signs of toxicity resolved within a few hr in all three cases, with no adverse drug effects. A methocarbamol CRI can be considered in animals presenting with pyrethroid intoxication.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA. william.draper.dvm@gmail.com
authors.forename: William E
authors.initials: WE
authors.lastname: Draper
authors.forename: Luiz
authors.initials: L
authors.lastname: Bolfer
authors.forename: Emily
authors.initials: E
authors.lastname: Cottam
authors.forename: Maureen
authors.initials: M
authors.lastname: McMichael
authors.forename: Thomas
authors.initials: T
authors.lastname: Schubert
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced / Q000188:drug therapy*; D002415:Cats; D004283:Dog Diseases / Q000139:chemically induced / Q000188:drug therapy*; D004285:Dogs; D062787:Drug Overdose / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007306:Insecticides / Q000506:poisoning; D008297:Male; D008721:Methocarbamol / Q000627:therapeutic use*; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D011722:Pyrethrins / Q000506:poisoning*; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D009125:Muscle Relaxants, Central; D011722:Pyrethrins; D008721:Methocarbamol