title: Vascular smooth muscle cell differentiation-2010.
abstract: Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes collectively defining this cell lineage. The discovery of myocardin and its close association with serum response factor has represented a major break-through for the molecular understanding of vascular smooth muscle cell differentiation. Retinoids have been shown to improve the outcome of vessel wall remodeling following injury and have provided further insights into the molecular circuitry that defines the vascular smooth muscle cell phenotype. This review summarizes the progress to date in each of these areas of vascular smooth muscle cell biology.
authors.affiliation: Aab Cardiovascular Research Institute, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Miano
references.citation: J Histochem Cytochem. 2006 Jun;54(6):701-11
references.pmid: 16461364
references.citation: J Biol Chem. 2004 Aug 13;279(33):34849-55
references.pmid: 15184395
references.citation: Circ Res. 2005 Nov 25;97(11):1132-41
references.pmid: 16224062
references.citation: Am J Pathol. 1990 Oct;137(4):761-5
references.pmid: 2221010
references.citation: Circ Res. 1994 Nov;75(5):803-12
references.pmid: 7923625
references.citation: J Biol Chem. 2005 Sep 2;280(35):31172-81
references.pmid: 15980430
references.citation: Cell. 1986 Aug 15;46(4):567-74
references.pmid: 3524858
references.citation: Circ Res. 2009 Jul 31;105(3):214-8
references.pmid: 19574550
references.citation: Cardiovasc Res. 2005 Mar 1;65(4):813-22
references.pmid: 15721861
references.citation: Biochim Biophys Acta. 1995 Jul 28;1242(1):1-10
references.pmid: 7626651
references.citation: Nat Rev Mol Cell Biol. 2004 Dec;5(12):959-70
references.pmid: 15573134
references.citation: J Clin Invest. 2009 Sep;119(9):2634-47
references.pmid: 19690389
references.citation: Biochem Biophys Res Commun. 2003 Jan 31;301(1):78-83
references.pmid: 12535643
references.citation: Dev Dyn. 2001 Aug;221(4):460-3
references.pmid: 11500983
references.citation: Curr Opin Cell Biol. 2007 Dec;19(6):618-27
references.pmid: 18023168
references.citation: Science. 1988 Oct 21;242(4877):405-11
references.pmid: 3175662
references.citation: Circ Res. 1996 Nov;79(5):1046-53
references.pmid: 8888698
references.citation: J Clin Invest. 2005 Feb;115(2):418-27
references.pmid: 15690088
references.citation: Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):89-95
references.pmid: 10634804
references.citation: J Biol Chem. 1996 Jan 5;271(1):395-403
references.pmid: 8550594
references.citation: Cell. 2001 Jun 29;105(7):851-62
references.pmid: 11439182
references.citation: Genes Dev. 2009 Sep 15;23(18):2166-78
references.pmid: 19720868
references.citation: FASEB J. 1991 Dec;5(15):3071-7
references.pmid: 1683845
references.citation: Curr Top Dev Biol. 2001;51:69-89
references.pmid: 11236716
references.citation: Circ Res. 1999 Apr 2;84(6):647-54
references.pmid: 10189352
references.citation: J Biol Chem. 2005 Mar 18;280(11):10861-9
references.pmid: 15657056
references.citation: Physiol Rev. 2004 Jul;84(3):767-801
references.pmid: 15269336
references.citation: Circ Res. 2009 Jul 17;105(2):158-66
references.pmid: 19542014
references.citation: Cell. 1987 Dec 24;51(6):987-1000
references.pmid: 3690668
references.citation: J Biol Chem. 2004 Oct 8;279(41):42422-30
references.pmid: 15292266
references.citation: Am J Physiol Cell Physiol. 2004 Dec;287(6):C1560-8
references.pmid: 15306544
references.citation: Semin Hematol. 1994 Oct;31(4 Suppl 5):1-13
references.pmid: 7831579
references.citation: Cell. 2009 May 15;137(4):647-58
references.pmid: 19409607
references.citation: Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):543-53
references.pmid: 12615665
references.citation: Development. 1999 Jun;126(14):3047-55
references.pmid: 10375497
references.citation: J Mol Cell Cardiol. 2002 Oct;34(10):1345-56
references.pmid: 12392995
references.citation: J Biol Chem. 2005 May 13;280(19):19115-26
references.pmid: 15699019
references.citation: FASEB J. 1997 Sep;11(11):905-15
references.pmid: 9285489
references.citation: Cell Death Differ. 2009 Dec;16(12):1590-8
references.pmid: 19816508
references.citation: Ann N Y Acad Sci. 2001 Dec;947:271-92; discussion 292-3
references.pmid: 11795276
references.citation: J Mol Cell Cardiol. 2003 Jun;35(6):577-93
references.pmid: 12788374
references.citation: Nature. 2008 Nov 27;456(7221):470-6
references.pmid: 18978772
references.citation: New Biol. 1991 May;3(5):455-64
references.pmid: 1909174
references.citation: J Cell Sci. 1995 Feb;108 ( Pt 2):537-44
references.pmid: 7768999
references.citation: Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2493-503
references.pmid: 16798818
references.citation: Semin Cell Biol. 1994 Apr;5(2):115-25
references.pmid: 8068884
references.citation: Biochem Biophys Res Commun. 2008 Oct 3;374(4):731-6
references.pmid: 18671946
references.citation: Biochem Biophys Res Commun. 2001 Feb 23;281(2):475-82
references.pmid: 11181072
references.citation: Am J Physiol Cell Physiol. 2009 Apr;296(4):C711-23
references.pmid: 19036941
references.citation: J Clin Invest. 2008 Feb;118(2):515-25
references.pmid: 18188448
references.citation: Cell. 1986 Dec 5;47(5):649-56
references.pmid: 2430720
references.citation: Circ Res. 2008 Mar 14;102(5):554-61
references.pmid: 18187733
references.citation: Science. 1997 Jul 11;277(5323):242-5
references.pmid: 9211853
references.citation: Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1505-10
references.pmid: 18451334
references.citation: J Cell Biol. 1988 Dec;107(6 Pt 2):2575-86
references.pmid: 3204121
references.citation: J Vasc Res. 1997 Jul-Aug;34(4):245-59
references.pmid: 9256084
references.citation: J Biol Chem. 1996 Mar 22;271(12):7095-103
references.pmid: 8636144
references.citation: Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7129-34
references.pmid: 12756293
references.citation: Nat Cell Biol. 2007 Sep;9(9):1000-4
references.pmid: 17762890
references.citation: Circulation. 1998 Sep 22;98(12):1219-27
references.pmid: 9743514
references.citation: Exp Mol Pathol. 1970 Jun;12(3):354-62
references.pmid: 5425010
references.citation: Front Biosci. 2002 Aug 01;7:d1782-97
references.pmid: 12133808
references.citation: J Biol Chem. 2003 Mar 28;278(13):11661-9
references.pmid: 12538588
references.citation: Circ Res. 2003 May 2;92(8):856-64
references.pmid: 12663482
references.citation: J Biol Chem. 2005 Feb 11;280(6):4745-52
references.pmid: 15550397
references.citation: Genome Res. 2006 Feb;16(2):197-207
references.pmid: 16365378
references.citation: Am J Physiol Cell Physiol. 2007 Jan;292(1):C70-81
references.pmid: 16928770
references.citation: J Biol Chem. 2001 Jan 5;276(1):341-7
references.pmid: 11035001
references.citation: Cardiovasc Res. 2006 Jul 1;71(1):170-8
references.pmid: 16603140
references.citation: Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9349-54
references.pmid: 18591670
references.citation: Arterioscler Thromb Vasc Biol. 1999 Jun;19(6):1430-6
references.pmid: 10364073
references.citation: Mol Genet Genomics. 2008 Aug;280(2):127-37
references.pmid: 18509681
references.citation: FEBS J. 2009 Mar;276(5):1356-69
references.pmid: 19187242
references.citation: J Biol Chem. 2001 Sep 7;276(36):34175-81
references.pmid: 11447226
references.citation: Exp Mol Pathol. 1985 Apr;42(2):139-62
references.pmid: 3884359
references.citation: Circ Res. 1996 Feb;78(2):188-95
references.pmid: 8575061
references.citation: Nat Cell Biol. 2009 May;11(5):557-68
references.pmid: 19350017
references.citation: Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):42-8
references.pmid: 17082491
references.citation: Nature. 2009 Aug 6;460(7256):705-10
references.pmid: 19578358
references.citation: EMBO J. 1996 Nov 15;15(22):6301-10
references.pmid: 8947053
references.citation: Curr Opin Genet Dev. 2004 Oct;14(5):558-66
references.pmid: 15380248
references.citation: Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14855-60
references.pmid: 12397177
references.citation: Results Probl Cell Differ. 2002;38:39-59
references.pmid: 12132398
references.citation: J Biol Chem. 2005 Mar 11;280(10):9719-27
references.pmid: 15623517
references.citation: Arteriosclerosis. 1989 May-Jun;9(3):289-98
references.pmid: 2719591
references.citation: Circulation. 1996 May 15;93(10):1886-95
references.pmid: 8635268
references.citation: BMC Mol Biol. 2004 Aug 25;5:13
references.pmid: 15329155
references.citation: Circ Res. 2000 Nov 10;87(10):881-7
references.pmid: 11073883
references.citation: J Vasc Surg. 2007 Jun;45 Suppl A:A25-32
references.pmid: 17544021
references.citation: Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9366-70
references.pmid: 12867591
references.citation: Mol Cell. 2004 Dec 22;16(6):867-80
references.pmid: 15610731
references.citation: Nature. 1953 Apr 25;171(4356):737-8
references.pmid: 13054692
references.citation: J Biol Chem. 1997 Oct 17;272(42):26643-51
references.pmid: 9334246
references.citation: Cell. 2004 Jan 23;116(2):281-97
references.pmid: 14744438
references.citation: Circ Res. 2009 Jul 31;105(3):271-8
references.pmid: 19574551
references.citation: Circ Res. 2005 Nov 11;97(10):983-91
references.pmid: 16224064
references.citation: Cardiovasc Pathol. 2007 Jul-Aug;16(4):212-20
references.pmid: 17637429
references.citation: J Biol Chem. 2005 Feb 11;280(6):4125-34
references.pmid: 15590635
references.citation: Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17132-7
references.pmid: 15569937
references.citation: Circ Res. 2010 Mar 19;106(5):870-9
references.pmid: 20093628
references.citation: Development. 1995 Feb;121(2):489-503
references.pmid: 7539357
references.citation: Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):225-31
references.pmid: 19023090
references.citation: Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1454-61
references.pmid: 18535287
references.citation: Mol Cell Biol. 2003 Apr;23(7):2425-37
references.pmid: 12640126
references.citation: J Biol Chem. 1999 Jan 22;274(4):2308-14
references.pmid: 9890996
references.citation: J Biol Chem. 2004 Dec 31;279(53):56014-23
references.pmid: 15496411
references.citation: Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1248-58
references.pmid: 17379839
references.citation: J Cell Biol. 2004 May 24;165(4):483-91
references.pmid: 15148306
references.citation: Atherosclerosis. 2007 Dec;195(2):303-12
references.pmid: 17275006