title: The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles.
abstract: A three-component reaction has been developed that allows the regioselective synthesis of thieno[2,3-c]pyrroles. The reaction is based on the ability of 2-acetyl-3-thiophenecarboxaldehyde to react with amine and thiol nucleophiles to produce the corresponding tri-substituted thieno[2,3-c]pyrroles, with water as the only by-product. The developed reaction expands the range of synthetically accessible, tri-substituted thieno[2,3-c]pyrroles.
authors.affiliation: Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Silverman Hall, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Hong
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Statsyuk
mesh_terms: D000588:Amines / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry; D009764:o-Phthalaldehyde / Q000737:chemistry
chemical_list: D000588:Amines; D011758:Pyrroles; D014867:Water; D009764:o-Phthalaldehyde