title: Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature.
abstract: Brown tumor is a bone lesion secondary to hyperparathyroidism of various etiologies. Skeletal involvement in primary hyperparathyroidism secondary to parathyroid adenoma is very uncommon and brown tumor has become extremely a rare clinical entity. Hyperparathyroidism is usually associated with high levels of serum calcium. Brown tumor as the only and initial symptom of normocalcemic primary hyperparathyroidism is extremely rare. Moreover, involvement of the skull base and the orbit is exceedingly rare. The authors would report three cases of brown tumor of the anterior skull base that were associated with true normocalcemic primary hyperparathyroidism. Clinical manifestations, neuroimaging findings, pathological findings, diagnosis and treatment of the patients are discussed and the relevant literature is reviewed.
authors.affiliation: Arad Hospital, Department of Neurosurgery, Tehran, Islamic Republic of Iran. mrkhalatbari@hotmail.com
authors.forename: Mahmoud Reza
authors.initials: MR
authors.lastname: Khalatbari
authors.forename: Mehrdokht
authors.initials: M
authors.lastname: Hamidi
authors.forename: Yashar
authors.initials: Y
authors.lastname: Moharamzad
authors.forename: Ali
authors.initials: A
authors.lastname: Setayesh
authors.forename: Abbas
authors.initials: A
authors.lastname: Amirjamshidi
mesh_terms: D000236:Adenoma / Q000150:complications / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000209:etiology / Q000473:pathology* / Q000601:surgery*; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000473:pathology / Q000601:surgery; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D019635:Neurosurgical Procedures; D010282:Parathyroid Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery; D019291:Skull Base / Q000473:pathology* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome