title: The concentrations of IL-8 and IL-6 in gingival crevicular fluid during nickel-chromium alloy porcelain crown restoration.
abstract: We explored gum irritation and cytotoxicity caused by nickel-chromium (Ni-Cr) alloy porcelain by interleukin-8 (IL-8), interleukin-6 (IL-6) and gingival crevicular fluid (GCF) volumes at different time points peri-crown restoration. This prospective study was conducted in 60 young adults. The total amount and concentrations of IL-8 and IL-6 per site, GCF volumes, and blood neutrophil counts were performed prior to and at 1 week, 3 months, and 6 months after Ni-Cr alloy-porcelain crown restoration. Thirty male and 30 female subjects, aged 20-35 years old were enrolled. The total amount and concentrations of IL-8 and IL-6 per site, GCF volumes increased after nickel-chromium (Ni-Cr) alloy-porcelain crown restoration, and reached its peak at the third month as the GCF volume increased by 52.20 %, the total amount and concentrations of IL-8 increased by 112.11 and 22.75 %; the total amount and concentrations of IL-6 increased by 77.66 and 17.17 % when compared to baseline. In particular, the increase of IL-8 concentration was found in female patients at 3 months after restoration; while the neutrophil count of the peripheral blood did not change significantly. The increase in the total amount and the concentrations of IL-8 and IL-6 and GCF volume may be related to the cytotoxicity induced by Ni-Cr alloy. The significant increase of IL-8 concentration in females indicates that more attention should be given to women during Ni-Cr alloy porcelain crown restoration.
authors.affiliation: Department of Stomatology, The Sixth Affiliated People's Hospital of Shanghai Jiaotong University, No. 600 Yi Shan Road, Shanghai, 200233, China. lufeng_yu@hotmail.com
authors.forename: Lufeng
authors.initials: L
authors.lastname: Yu
authors.forename: JianSheng
authors.initials: J
authors.lastname: Su
authors.forename: DeRong
authors.initials: D
authors.lastname: Zou
authors.forename: Zana
authors.initials: Z
authors.lastname: Mariano
mesh_terms: D000328:Adult; D002858:Chromium Alloys / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D003442:Crowns; D058250:Dental Restoration Repair / Q000379:methods; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis / Q000378:metabolism*; D016209:Interleukin-8 / Q000032:analysis / Q000378:metabolism*; D007958:Leukocyte Count; D008297:Male; D016876:Metal Ceramic Alloys / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D009504:Neutrophils / Q000166:cytology / Q000378:metabolism; D013997:Time Factors; D055815:Young Adult
chemical_list: D002858:Chromium Alloys; D015850:Interleukin-6; D016209:Interleukin-8; D016876:Metal Ceramic Alloys
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