title: Hydrolysis profiling: an in vitro methodology to predict in vivo absorption time.
abstract: An in vitro method was developed for estimating in vivo degradation time of sutures made from synthetic bioresorbable polyesters. Model compounds and a number of commercially available bioresorbable suture products were used to establish the applicability of this hydrolysis profile methodology. Hydrolysis profiles on tested bioresorbable sutures were determined as a function of size and chemical composition. This method of accelerated absorption testing may shorten product development time and reduce the need for animal testing. In addition, the methodologies presented have the potential to provide insight into the loss of mechanical properties with time.
authors.affiliation: Research and Development, Ethicon Inc. (A Johnson & Johnson Company), US Route 22 West, Somerville, New Jersey, USA. bfitz@its.jnj.com
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Fitz
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Jamiolkowski
mesh_terms: D000042:Absorption; D001672:Biocompatible Materials / Q000737:chemistry; D006801:Humans; D006868:Hydrolysis; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry; D013537:Sutures
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters
keywords: absorption time; bioabsorption; bioresorbable polyesters; in vivo/in vitro test methods; sutures