title: Angiogenic and inflammatory markers in acute respiratory distress syndrome and renal injury associated to A/H1N1 virus infection.
abstract: Acute kidney injury (AKI) is often associated to acute respiratory distress syndrome (ARDS) due to influenza A/H1N1 virus infection. The profile of angiogenic and inflammatory factors in ARDS patients may be relevant for AKI. We analyzed the serum levels of several angiogenic factors, cytokines, and chemokines in 32 patients with A/H1N1 virus infection (17 with ARDS/AKI and 15 ARDS patients who did not developed AKI) and in 18 healthy controls. Significantly higher levels of VEGF, MCP-1, IL-6, IL-8 and IP-10 in ARDS/AKI patients were detected. Adjusting by confusing variables, levels of MCP-1 ≥150 pg/mL (OR=12.0, p=0.04) and VEGF ≥225 pg/mL (OR=6.4, p=0.03) were associated with the development of AKI in ARDS patients. Higher levels of MCP-1 and IP-10 were significantly associated with a higher risk of death in patients with ARDS (hazard ratio (HR)=10.0, p=0.02; HR=25.5, p=0.03, respectively) even taking into account AKI. Patients with influenza A/H1N1 infection and ARDS/AKI have an over-production of MCP-1, VEGF and IP-10 possibly contributing to kidney injury and are associated to a higher risk of death.
authors.affiliation: Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan 4502, Tlalpan, 14080, Mexico City, Mexico. drbautista40@iner.gob.mx
authors.forename: Edgar
authors.initials: E
authors.lastname: Bautista
authors.forename: Magali
authors.initials: M
authors.lastname: Arcos
authors.forename: Luís
authors.initials: L
authors.lastname: Jimenez-Alvarez
authors.forename: Ma Cecilia
authors.initials: MC
authors.lastname: García-Sancho
authors.forename: María E
authors.initials: ME
authors.lastname: Vázquez
authors.forename: Erika
authors.initials: E
authors.lastname: Peña
authors.forename: Anjarath
authors.initials: A
authors.lastname: Higuera
authors.forename: Gustavo
authors.initials: G
authors.lastname: Ramírez
authors.forename: Rosario
authors.initials: R
authors.lastname: Fernández-Plata
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cruz-Lagunas
authors.forename: Sara A
authors.initials: SA
authors.lastname: García-Moreno
authors.forename: Francisco
authors.initials: F
authors.lastname: Urrea
authors.forename: Remedios
authors.initials: R
authors.lastname: Ramírez
authors.forename: Ricardo
authors.initials: R
authors.lastname: Correa-Rotter
authors.forename: José Rogelio
authors.initials: JR
authors.lastname: Pérez-Padilla
authors.forename: Joaquín
authors.initials: J
authors.lastname: Zúñiga
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism* / Q000401:mortality / Q000821:virology; D000328:Adult; D042501:Angiogenic Proteins / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D018932:Chemokine CCL2 / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification; D007251:Influenza, Human / Q000150:complications / Q000378:metabolism* / Q000401:mortality; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D012128:Respiratory Distress Syndrome / Q000378:metabolism* / Q000401:mortality / Q000821:virology; D015996:Survival Rate; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D042501:Angiogenic Proteins; D015415:Biomarkers; C111835:CCL2 protein, human; C114753:CXCL10 protein, human; D018932:Chemokine CCL2; D054357:Chemokine CXCL10; D042461:Vascular Endothelial Growth Factor A