title: Progress in the studies on tryptanthrin, an alkaloid of history.
abstract: Tryptanthrin, an indoloquinazoline alkaloid, was first obtained by sublimation of natural indigo and later isolated from the culture of fungus Candida lipolytica and a variety of other natural sources. Tryptanthrin showed a variety of intriguing biological properties such as antibacterial, antifungal, antiprotozoal, and antiparasitic activities, inhibitory activities against COX-2, 5-LOX, NO synthase and PGE(2) expression, as well as cytotoxic and antitumor activities. Present review covers recent studies on the natural sources, biological activities and mechanisms of their actions, synthesis, structure-activity relationship, and metabolism of tryptanthrin.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, South Korea. ydjahng@ynu.ac.kr
authors.forename: Yurngdong
authors.initials: Y
authors.lastname: Jahng
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D055808:Drug Discovery; D006801:Humans; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D011799:Quinazolines; C046243:tryptanthrine