title: Understanding the pathophysiology of itch.
abstract: Itch is the most common symptom described by our patients. Treating this symptom can be challenging. A revolution is ongoing in understanding the pathophysiology of itch and will allow this challenge to be met. The present authors review and update the current understanding of the pathophysiology of itch.
authors.affiliation: Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.
authors.forename: Lilit
authors.initials: L
authors.lastname: Garibyan
authors.forename: Curtis G
authors.initials: CG
authors.lastname: Rheingold
authors.forename: Ethan A
authors.initials: EA
authors.lastname: Lerner
mesh_terms: D006801:Humans; D011537:Pruritus / Q000209:etiology / Q000503:physiopathology*; D011788:Quality of Life; D012871:Skin Diseases / Q000503:physiopathology
references.citation: Skin Pharmacol Physiol. 2010;23(3):133-8
references.pmid: 20051714
references.citation: Trends Pharmacol Sci. 2005 Sep;26(9):462-9
references.pmid: 16054239
references.citation: Nat Rev Neurosci. 2006 Jul;7(7):535-47
references.pmid: 16791143
references.citation: Semin Dermatol. 1995 Dec;14(4):271-6
references.pmid: 8679431
references.citation: Nature. 1997 Oct 23;389(6653):816-24
references.pmid: 9349813
references.citation: Dermatol Clin. 2005 Oct;23(4):591-9
references.pmid: 16112434
references.citation: J Allergy Clin Immunol. 2007 Jan;119(1):176-83
references.pmid: 17208599
references.citation: J Invest Dermatol. 1991 Sep;97(3):555-61
references.pmid: 1831466
references.citation: J Am Acad Dermatol. 2003 Jun;48(6):825-8
references.pmid: 12789170
references.citation: Nat Immunol. 2004 Jul;5(7):752-60
references.pmid: 15184896
references.citation: Pharmacol Rev. 1999 Jun;51(2):159-212
references.pmid: 10353985
references.citation: Nat Med. 2000 Feb;6(2):151-8
references.pmid: 10655102
references.citation: Acta Derm Venereol. 2012 Mar;92(2):118-25
references.pmid: 22307048
references.citation: J Invest Dermatol. 2003 Dec;121(6):xiv-xv
references.pmid: 14675224
references.citation: Arch Dermatol. 1999 Dec;135(12):1522-5
references.pmid: 10606058
references.citation: Neurosci Lett. 2010 Feb 19;470(3):193-6
references.pmid: 19576959
references.citation: Br J Dermatol. 2007 Jun;156(6):1272-7
references.pmid: 17535226
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11330-5
references.pmid: 19564617
references.citation: Pain. 2002 Mar;96(1-2):9-12
references.pmid: 11932056
references.citation: Int J Psychiatry Med. 1992;22(1):47-63
references.pmid: 1577548
references.citation: Biochem Biophys Res Commun. 2001 Aug 3;285(5):1250-2
references.pmid: 11478791
references.citation: Br J Dermatol. 1997 Jun;136(6):871-7
references.pmid: 9217819
references.citation: Neuroreport. 2010 Mar 10;21(4):303-8
references.pmid: 20125052
references.citation: Curr Med Chem. 2004 Aug;11(15):2045-81
references.pmid: 15279567
references.citation: Cereb Cortex. 2014 Apr;24(4):873-82
references.pmid: 23222890
references.citation: Dermatol Ther. 2008 Jan-Feb;21(1):32-41
references.pmid: 18318883
references.citation: Dermatology. 2002;204(2):88-93
references.pmid: 11937731
references.citation: Neurobiol Dis. 1996;3(3):205-14
references.pmid: 8980021
references.citation: Clin Exp Allergy. 2009 Dec;39(12):1786-800
references.pmid: 20085595
references.citation: J Invest Dermatol. 2004 Aug;123(2):410-3
references.pmid: 15245445
references.citation: Arch Dermatol. 2003 Nov;139(11):1475-8
references.pmid: 14623707
references.citation: Ann Neurol. 1998 Nov;44(5):789-95
references.pmid: 9818935
references.citation: Nat Neurosci. 2013 Feb;16(2):174-82
references.pmid: 23263443
references.citation: Curr Opin Neurobiol. 2011 Dec;21(6):880-7
references.pmid: 22054924
references.citation: Lancet. 2003 Feb 22;361(9358):690-4
references.pmid: 12606187
references.citation: Br J Pharmacol. 2004 May;142(2):374-80
references.pmid: 15066908
references.citation: Exp Dermatol. 2004 Mar;13(3):129-39
references.pmid: 14987252
references.citation: J Neurosci. 1997 Oct 15;17(20):8003-8
references.pmid: 9315918
references.citation: J Neurosci. 2003 Jul 16;23(15):6176-80
references.pmid: 12867500
references.citation: Dermatol Ther. 2005 Jul-Aug;18(4):314-22
references.pmid: 16297003
references.citation: Am J Clin Dermatol. 2003;4(9):617-22
references.pmid: 12926980
references.citation: J Am Acad Dermatol. 2005 Jan;52(1):142-5
references.pmid: 15627097
references.citation: J Immunol. 2006 Jun 1;176(11):7062-70
references.pmid: 16709868
references.citation: J Allergy Clin Immunol. 2006 Feb;117(2):411-7
references.pmid: 16461142
references.citation: Exp Physiol. 2002 Mar;87(2):239-44
references.pmid: 11856969
references.citation: J Neurosci. 2007 Feb 28;27(9):2331-7
references.pmid: 17329430
references.citation: ACS Chem Neurosci. 2011 Jan 19;2(1):17-25
references.pmid: 21720568
references.citation: Exp Dermatol. 2009 Jan;18(1):35-43
references.pmid: 19054054
references.citation: Neurosci Lett. 1995 Mar 10;187(3):157-60
references.pmid: 7624016
references.citation: Br J Dermatol. 2009 Dec;161(6):1217-24
references.pmid: 19663869
references.citation: Curr Allergy Asthma Rep. 2010 Jul;10(4):236-42
references.pmid: 20428977
references.citation: AMA Arch Derm. 1957 Sep;76(3):296-323
references.pmid: 13457411
references.citation: J Neurosci. 2008 Apr 23;28(17):4331-5
references.pmid: 18434511
references.citation: Arch Dermatol. 2011 Oct;147(10):1153-6
references.pmid: 21680760
references.citation: CNS Drugs. 2001;15(5):351-9
references.pmid: 11475941
references.citation: Int J Dermatol. 2010 Aug;49(8):858-65
references.pmid: 21128913
references.citation: Life Sci. 2006 Nov 10;79(24):2303-10
references.pmid: 16950406
references.citation: J Invest Dermatol. 2000 Dec;115(6):1015-20
references.pmid: 11121135
references.citation: J Am Acad Dermatol. 2003 Apr;48(4):521-4
references.pmid: 12664013