title: Mesenteric paraganglioma: Report of a case.
abstract: We report a rare case of paraganglioma that developed in the mesentery of terminal ileum. A 78-year-old woman complained of right-sided abdominal pain. Abdominal computed tomography revealed a solid heterogeneously enhanced mass in the right lower abdomen. The tumor was laparoscopically excised. The mesenteric tumor was well circumscribed, ovoid, and encapsulated and measured 3 cm × 1.5 cm × 1.5 cm. Histological examination showed a cellular neoplasm comprised of nests and groups of tumor cells separated by fibrovascular connective tissue, giving a characteristic nested Zellballen pattern. Immunohistochemically, the tumor cells were positive for chromogranin, synaptophysin, CD56, and vimentin and negative for cytokeratins, SMA, CD34, CD117/c-kit and S100. On the basis of histologic and immunohistochemical features, a diagnosis of mesenteric paraganglioma was made. The operative and postoperative courses were unremarkable, and the patient was discharged on postoperative day 7. She was doing well 1 year after the surgery with no signs of recurrence. Extra-adrenal paragangliomas most commonly develop adjacent to the aorta, particularly the area corresponding to the organ of Zuckerkandl. Mesenteric paraganglioma, as in our case, is extremely rare; only 11 cases have been reported in the literature. We herein discuss the clinical findings of these cases.
authors.affiliation: Takeshi Fujita, Kinji Kamiya, Yoshiaki Takahashi, Shinichiro Miyazaki, Ichirota Iino, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Manabu Ohta, Hiroyuki Konno, Second Department of Surgery, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fujita
authors.forename: Kinji
authors.initials: K
authors.lastname: Kamiya
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Ichirota
authors.initials: I
authors.lastname: Iino
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Kikuchi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hiramatsu
authors.forename: Manabu
authors.initials: M
authors.lastname: Ohta
authors.forename: Satoshi
authors.initials: S
authors.lastname: Baba
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Konno
keywords: Extra-adrenal paraganglioma; Mesenteric tumor; Pheochromocytoma; Preoperative diagnosis; Surgical management
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