title: Distinctive amygdala subregions involved in emotion-modulated Stroop interference.
abstract: Despite the well-known role of the amygdala in mediating emotional interference during tasks requiring cognitive resources, no definite conclusion has yet been reached regarding the differential roles of functionally and anatomically distinctive subcomponents of the amygdala in such processes. In this study, we examined female participants and attempted to separate the neural processes for the detection of emotional information from those for the regulation of cognitive interference from emotional distractors by adding a temporal gap between emotional stimuli and a subsequent cognitive Stroop task. Reaction time data showed a significantly increased Stroop interference effect following emotionally negative stimuli compared with neutral stimuli, and functional magnetic resonance imaging data revealed that the anterior ventral amygdala (avAMYG) showed greater responses to negative stimuli compared with neutral stimuli. In addition, individuals who scored high in neuroticism showed greater posterior dorsal amygdala (pdAMYG) responses to incongruent compared with congruent Stroop trials following negative stimuli, but not following neutral stimuli. Taken together, the findings of this study demonstrated functionally distinctive contributions of the avAMYG and pdAMYG to the emotion-modulated Stroop interference effect and suggested that the avAMYG encodes associative values of emotional stimuli whereas the pdAMYG resolves cognitive interference from emotional distractors.
authors.affiliation: or Hyun Taek Kim, PhD, Department of Psychology, Korea University, 1-5 Anam-dong, Seongbuk-Gu, Seoul 136-701, Republic of Korea. hackjinkim@korea.ac.kr.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Han
authors.forename: Kanghee
authors.initials: K
authors.lastname: Lee
authors.forename: Hyun Taek
authors.initials: HT
authors.lastname: Kim
authors.forename: Hackjin
authors.initials: H
authors.lastname: Kim
mesh_terms: D000679:Amygdala / Q000502:physiology*; D001008:Anxiety Disorders / Q000503:physiopathology; D001931:Brain Mapping; D004644:Emotions / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D000075384:Neuroticism; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010551:Personality / Q000502:physiology; D011930:Reaction Time; D011932:Reading; D057190:Stroop Test; D013647:Task Performance and Analysis; D055815:Young Adult
keywords: Stroop; cingulate cortex; emotion; fMRI; neuroticism
references.citation: Brain Res. 1980 May 26;190(2):347-68
references.pmid: 6768425
references.citation: Emotion. 2001 Mar;1(1):70-83
references.pmid: 12894812
references.citation: J Comp Neurol. 2000 May 22;421(1):52-79
references.pmid: 10813772
references.citation: Comput Biomed Res. 1996 Jun;29(3):162-73
references.pmid: 8812068
references.citation: Neuroreport. 2001 Dec 21;12(18):3953-7
references.pmid: 11742218
references.citation: J Neurosci. 2004 Nov 17;24(46):10364-8
references.pmid: 15548650
references.citation: Biol Psychiatry. 1998 Dec 15;44(12):1219-28
references.pmid: 9861465
references.citation: Am J Psychiatry. 2003 Oct;160(10):1726-39
references.pmid: 14514480
references.citation: Cogn Affect Behav Neurosci. 2010 Sep;10(3):357-71
references.pmid: 20805537
references.citation: Neuroimage. 2011 May 1;56(1):299-306
references.pmid: 21320610
references.citation: Neuroimage. 1997 Aug;6(2):122-38
references.pmid: 9299386
references.citation: Hum Brain Mapp. 2011 Feb;32(2):198-208
references.pmid: 20715084
references.citation: Neurosci Lett. 2003 Sep 4;348(1):41-5
references.pmid: 12893421
references.citation: Neuron. 2006 Sep 21;51(6):871-82
references.pmid: 16982430
references.citation: Neurosci Lett. 2010 Jan 22;469(2):260-4
references.pmid: 20005920
references.citation: Brain. 1998 Dec;121 ( Pt 12):2249-57
references.pmid: 9874478
references.citation: Behav Cogn Neurosci Rev. 2003 Jun;2(2):115-29
references.pmid: 13678519
references.citation: Soc Cogn Affect Neurosci. 2007 Dec;2(4):303-12
references.pmid: 18985136
references.citation: Behav Neurosci. 1994 Feb;108(1):81-93
references.pmid: 8192853
references.citation: Cereb Cortex. 2010 Mar;20(3):612-21
references.pmid: 19556348
references.citation: J Neurosci. 2012 Jun 13;32(24):8383-90
references.pmid: 22699918
references.citation: Psychophysiology. 2007 May;44(3):343-51
references.pmid: 17433093
references.citation: Ann Behav Med. 2009 Apr;37(2):126-40
references.pmid: 19381748
references.citation: Folia Morphol (Warsz). 2000;59(1):1-23
references.pmid: 10774087
references.citation: Nat Rev Neurosci. 2008 Feb;9(2):148-58
references.pmid: 18209732
references.citation: Neuron. 2011 Feb 10;69(3):563-71
references.pmid: 21315265
references.citation: Nat Rev Neurosci. 2009 Jun;10(6):410-22
references.pmid: 19455173
references.citation: Behav Neurosci. 2007 Apr;121(2):249-56
references.pmid: 17469914
references.citation: Neuroimage. 2010 Jan 1;49(1):963-70
references.pmid: 19683585
references.citation: Cereb Cortex. 2008 Jun;18(6):1475-84
references.pmid: 17940084
references.citation: Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11458-63
references.pmid: 12177449
references.citation: Behav Neurosci. 2001 Feb;115(1):33-42
references.pmid: 11256451
references.citation: Neuroimage. 2001 Dec;14(6):1302-8
references.pmid: 11707086
references.citation: Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16524-9
references.pmid: 16258067
references.citation: Cogn Affect Behav Neurosci. 2005 Jun;5(2):169-81
references.pmid: 16180623
references.citation: Cogn Affect Behav Neurosci. 2006 Jun;6(2):152-6
references.pmid: 17007235
references.citation: Psychoneuroendocrinology. 2005 Nov;30(10):953-8
references.pmid: 15963650
references.citation: Trends Cogn Sci. 2007 Jul;11(7):307-16
references.pmid: 17553730
references.citation: J Neurosci. 1981 Nov;1(11):1242-59
references.pmid: 6171630
references.citation: Cereb Cortex. 2010 Jul;20(7):1596-603
references.pmid: 19840974
references.citation: Neuron. 2004 Dec 16;44(6):1043-55
references.pmid: 15603746
references.citation: J Neurosci. 2007 May 30;27(22):5958-66
references.pmid: 17537966
references.citation: Neuron. 2008 Sep 25;59(6):1037-50
references.pmid: 18817740
references.citation: Clin Psychol Rev. 1997 Nov;17(7):791-821
references.pmid: 9397338
references.citation: Neuroscience. 2002;115(4):1261-79
references.pmid: 12453496
references.citation: Nat Rev Neurosci. 2005 Jul;6(7):533-44
references.pmid: 15995724
references.citation: Neuroscience. 2002;111(1):133-49
references.pmid: 11955718
references.citation: Neuron. 2005 Aug 18;47(4):495-501
references.pmid: 16102533
references.citation: Proc Natl Acad Sci U S A. 2010 May 18;107(20):9400-5
references.pmid: 20421469
references.citation: J Neurosci. 2006 Feb 15;26(7):2072-9
references.pmid: 16481440
references.citation: Trends Cogn Sci. 2004 Dec;8(12):539-46
references.pmid: 15556023
references.citation: Prog Neurobiol. 1998 Jun;55(3):257-332
references.pmid: 9643556
references.citation: Arch Gen Psychiatry. 2009 Dec;66(12):1361-72
references.pmid: 19996041
references.citation: Science. 2004 Dec 17;306(5704):2061
references.pmid: 15604401
references.citation: Trends Cogn Sci. 2007 Dec;11(12):499-500
references.pmid: 18024182
references.citation: Eur J Neurosci. 2011 Jul;34(1):134-45
references.pmid: 21535456
references.citation: Neuroreport. 2003 Dec 19;14(18):2317-22
references.pmid: 14663183
references.citation: Neuroimage. 2001 Jun;13(6 Pt 1):1044-52
references.pmid: 11352610
references.citation: Cereb Cortex. 1998 Jun;8(4):372-84
references.pmid: 9651132
references.citation: Neuron. 2001 Jun;30(3):829-41
references.pmid: 11430815
references.citation: J Neurosci. 2011 Jan 12;31(2):618-23
references.pmid: 21228170
references.citation: Nat Rev Neurosci. 2011 Mar;12(3):154-67
references.pmid: 21331082