title: dUTPases, the unexplored family of signalling molecules.
abstract: Deciphering the molecular mechanisms that control relevant cellular processes is of utmost importance to understand how viruses, prokaryotic and eukaryotic cells work. The diversity of living organisms suggests that there are novel regulators still to be discovered, which may uncover new regulatory paradigms. dUTPases (Duts) are assumed to be ubiquitous enzymes regulating cellular dUTP levels to prevent misincorporation of uracil into DNA. Recently however, Duts have been involved in the control of several relevant cellular processes, including transfer of mobile genetic elements, regulation of the immune system, autoimmunity or apoptosis, suggesting that they perform regulatory functions. This review aims at investigating the unexplored impact of Duts as novel signalling molecules.
authors.affiliation: Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, 46010 Valencia, Spain. jpenades@ibv.csic.es
authors.forename: José R
authors.initials: JR
authors.lastname: Penadés
authors.forename: Jorge
authors.initials: J
authors.lastname: Donderis
authors.forename: María
authors.initials: M
authors.lastname: García-Caballer
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: Tormo-Más
authors.forename: Alberto
authors.initials: A
authors.lastname: Marina
mesh_terms: D003856:Deoxyuracil Nucleotides / Q000378:metabolism; D005057:Eukaryotic Cells / Q000502:physiology*; D005786:Gene Expression Regulation; D011387:Prokaryotic Cells / Q000502:physiology*; D011755:Pyrophosphatases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D003856:Deoxyuracil Nucleotides; C027078:deoxyuridine triphosphate; D011755:Pyrophosphatases; C020020:dUTP pyrophosphatase