title: Is the nystagmus pattern in hemi-labyrinthectomized subjects during positional alcohol nystagmus 2 similar to that found in patients with cupulolithiasis in the lateral semicircular canal?
abstract: CONCLUSIONS
  A positional nystagmus pattern compatible with a condition of a heavy cupula (cupulolithiasis) in the lateral semicircular canal could be reproduced in hemi-labyrinthectomized subjects during positional alcohol nystagmus 2 (PAN 2). The nystagmus pattern was opposite to that found in the same subjects during PAN 1. The affected side could not be judged by applying Ewald's second law.
  
  
  OBJECTIVE
  To mimic the condition of a heavy cupula in the lateral semicircular canal by using unilaterally deafferented subjects during PAN 2 and compare (a) results reported in the literature with those of patients with cupulolithiasis, and (b) the nystagmus findings in the same subjects during PAN 1.
  
  
  METHODS
  Five hemi-labyrinthectomized subjects were studied during PAN 2 when they kept their heads pointed straight forward or turned sideways in the prone and supine positions, respectively.
  
  
  RESULTS
  When the subjects were examined with their heads turned in the supine or prone positions, the alcohol-induced nystagmus pattern was compatible with that of cupulolithiasis. When the head was pointed straight forward in the prone and supine positions, the nystagmus directions were opposite to those found during PAN 1. Directional preponderance was not seen for the apogeotropic nystagmus for either ampullofugal or ampullopetal deviation of the cupula.
authors.affiliation: Department of Audiology and Neurotology, Diagnostics and Dizziness Unit, Karolinska University Hospital, Stockholm, Sweden. tatjana.tomanovic@karolinska.se
authors.forename: Tatjana
authors.initials: T
authors.lastname: Tomanovic
authors.forename: Johan
authors.initials: J
authors.lastname: Bergenius
mesh_terms: D000328:Adult; D002492:Central Nervous System Depressants; D007758:Ear, Inner / Q000601:surgery; D000431:Ethanol; D005260:Female; D006801:Humans; D007759:Labyrinth Diseases / Q000503:physiopathology*; D008297:Male; D009759:Nystagmus, Pathologic; D009760:Nystagmus, Physiologic
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol