title: Can quadruple test parameters predict SGA infants?
abstract: The aim of this study was to investigate the role of quadruple test parameters in predicting the risk of delivering a small for gestational age (SGA) infant. The quadruple test results of patients performed at 16-18 weeks of pregnancy were searched retrospectively. Alpha-fetoprotein (AFP) levels higher than 2 MoM were associated with a risk of delivering an SGA infant (p = 0.025), sensitivity 8%, specificity 98%, positive predictive value 25%, negative predictive value 91%. Other quadruple test parameters were not related to delivery of an SGA infant. The introduction of AFP as a screening test for the detection of SGA infants does not seem feasible, but we suggest clinicians take it into account when counselling the patients about the results of Down syndrome screening tests.
authors.affiliation: Department of Obstetrics and Gynecology, Avrupa Hospital, Istanbul Bilim University, Istanbul, Turkey. nilgun.kutay@gmail.com
authors.forename: N
authors.initials: N
authors.lastname: Güdücü
authors.forename: G
authors.initials: G
authors.lastname: Gönenç
authors.forename: H
authors.initials: H
authors.lastname: Işçi
authors.forename: A Başgül
authors.initials: AB
authors.lastname: Yiğiter
authors.forename: I
authors.initials: I
authors.lastname: Dünder
mesh_terms: D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D004964:Estriol / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007265:Inhibins / Q000097:blood; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies; D055815:Young Adult; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; C422362:inhibin A; D007265:Inhibins; D004964:Estriol