title: Memory NK cells: why do they reside in the liver?
abstract: Immune memory is the hallmark of adaptive immunity. However, recent studies have shown that natural killer (NK) cells, key components of the innate immune system, also mediate memory responses in mice and humans. Strikingly, memory NK cells were liver-resident in some models, raising the question as to whether the liver is a special organ for the acquisition of NK cell memory. Here, we review the characteristics of NK cell memory by summarizing recent progress and discuss how the liver may generate both the initiation and the recall phase of memory. We propose that the liver may have unique precursors for memory NK cells, which are developmentally distinct from NK cells derived from bone marrow.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Jiang
authors.forename: Yonglin
authors.initials: Y
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Peng
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Tian
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology*; D008099:Liver / Q000166:cytology* / Q000276:immunology*; D018448:Models, Immunological
chemical_list: D000941:Antigens
references.citation: Nat Immunol. 2006 May;7(5):507-16
references.pmid: 16617337
references.citation: Science. 2012 Apr 6;336(6077):86-90
references.pmid: 22442384
references.citation: J Immunol. 1986 Nov 1;137(9):2735-9
references.pmid: 3489775
references.citation: Immunity. 2011 Jul 22;35(1):23-33
references.pmid: 21683626
references.citation: Hepatology. 2012 Oct;56(4):1557-66
references.pmid: 22544823
references.citation: Annu Rev Immunol. 2013;31:137-61
references.pmid: 23215646
references.citation: J Immunol. 2006 Feb 1;176(3):1517-24
references.pmid: 16424180
references.citation: J Clin Invest. 2013 Apr;123(4):1444-56
references.pmid: 23524967
references.citation: J Exp Med. 2012 May 7;209(5):947-54
references.pmid: 22493516
references.citation: Nature. 1997 Jul 10;388(6638):133-4
references.pmid: 9217150
references.citation: Science. 2001 Mar 23;291(5512):2413-7
references.pmid: 11264538
references.citation: Science. 1996 Apr 5;272(5258):54-60
references.pmid: 8600537
references.citation: J Immunol. 1979 Oct;123(4):1832-8
references.pmid: 383842
references.citation: J Clin Invest. 2011 Oct;121(10):3834-45
references.pmid: 21926465
references.citation: Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8744-9
references.pmid: 11447257
references.citation: Science. 2011 Jan 7;331(6013):44-9
references.pmid: 21212348
references.citation: Nat Med. 1996 Feb;2(2):198-203
references.pmid: 8574965
references.citation: PLoS One. 2012;7(3):e32821
references.pmid: 22457721
references.citation: J Leukoc Biol. 2008 Oct;84(4):1039-46
references.pmid: 18664530
references.citation: Immunol Today. 1990 Jul;11(7):237-44
references.pmid: 2201309
references.citation: J Clin Invest. 2013 Feb;123(2):594-9
references.pmid: 23281401
references.citation: Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1915-9
references.pmid: 19181844
references.citation: Nat Immunol. 2010 Dec;11(12):1080-2
references.pmid: 21079631
references.citation: Nature. 1999 Oct 14;401(6754):708-12
references.pmid: 10537110
references.citation: Trends Immunol. 2012 May;33(5):215-23
references.pmid: 22365572
references.citation: Nat Immunol. 2010 Dec;11(12):1127-35
references.pmid: 20972432
references.citation: Nature. 2000 Oct 5;407(6804):636-42
references.pmid: 11034213
references.citation: Blood. 2005 Sep 1;106(5):1574-80
references.pmid: 15870171
references.citation: Hepatology. 2008 Feb;47(2):729-36
references.pmid: 18167066
references.citation: Nature. 2005 Aug 4;436(7051):709-13
references.pmid: 16079848
references.citation: Clin Dev Immunol. 2012;2012:759765
references.pmid: 22203859
references.citation: Blood. 2003 Jun 15;101(12):4887-93
references.pmid: 12586624
references.citation: Eur J Immunol. 2001 Jun;31(6):1900-9
references.pmid: 11433387
references.citation: Immunity. 2009 May;30(5):721-30
references.pmid: 19427242
references.citation: Cell Mol Immunol. 2012 May;9(3):193-4
references.pmid: 22504953
references.citation: Cell Mol Immunol. 2012 Jan;9(1):11-9
references.pmid: 22020068
references.citation: Immunity. 1995 Oct;3(4):459-73
references.pmid: 7584137
references.citation: Nat Immunol. 2011 Jun;12(6):500-8
references.pmid: 21739673
references.citation: Cell Mol Immunol. 2012 Sep;9(5):373-4
references.pmid: 22885525
references.citation: Eur J Immunol. 2012 Jan;42(1):80-8
references.pmid: 21968602
references.citation: J Immunol. 2012 Nov 15;189(10):5082-8
references.pmid: 23077239
references.citation: J Exp Med. 1979 Dec 1;150(6):1549-54
references.pmid: 229190
references.citation: Blood. 2011 May 19;117(20):5449-52
references.pmid: 21422472
references.citation: Blood. 2012 Dec 6;120(24):4751-60
references.pmid: 22983442
references.citation: Eur J Immunol. 2009 Aug;39(8):2095-9
references.pmid: 19637201
references.citation: Immunity. 2006 Aug;25(2):331-42
references.pmid: 16901727
references.citation: Immunol Rev. 2010 May;235(1):286-96
references.pmid: 20536570
references.citation: Nat Rev Immunol. 2004 Nov;4(11):900-11
references.pmid: 15516969
references.citation: J Immunol. 2007 Apr 15;178(8):4764-70
references.pmid: 17404256
references.citation: Nature. 2001 Mar 1;410(6824):101-5
references.pmid: 11242050
references.citation: J Exp Med. 2011 Jan 17;208(1):13-21
references.pmid: 21173105
references.citation: J Immunol. 1978 Dec;121(6):2193-8
references.pmid: 722074
references.citation: Nature. 2009 Jan 29;457(7229):557-61
references.pmid: 19136945
references.citation: Nat Rev Immunol. 2003 Apr;3(4):269-79
references.pmid: 12669018
references.citation: J Clin Invest. 2012 Apr;122(4):1146-8
references.pmid: 22466655
references.citation: Scand J Immunol. 2011 Jul;74(1):52-61
references.pmid: 21352253
references.citation: Int Immunol. 1998 Nov;10(11):1703-11
references.pmid: 9846699
references.citation: Blood. 2009 May 28;113(22):5488-96
references.pmid: 19234143
references.citation: PLoS Pathog. 2011 Aug;7(8):e1002141
references.pmid: 21829360
references.citation: Cell Mol Immunol. 2011 Sep;8(5):433-40
references.pmid: 21706044
references.citation: J Immunol. 1972 Dec;109(6):1386-94
references.pmid: 4673617
references.citation: Trends Immunol. 2005 Jul;26(7):360-6
references.pmid: 15978522
references.citation: Nat Rev Immunol. 2012 Feb 24;12(3):201-13
references.pmid: 22362353
references.citation: Trends Immunol. 2012 Feb;33(2):98-102
references.pmid: 22075207
references.citation: Nat Immunol. 2002 Jun;3(6):523-8
references.pmid: 12006976
references.citation: Annu Rev Immunol. 2004;22:405-29
references.pmid: 15032583
references.citation: Nat Rev Immunol. 2010 Mar;10(3):193-200
references.pmid: 20154734
references.citation: Blood. 2011 Nov 17;118(20):5439-47
references.pmid: 21931117
references.citation: Cell Mol Immunol. 2012 Jul;9(4):310-20
references.pmid: 22705914
references.citation: Immunity. 2005 Feb;22(2):259-70
references.pmid: 15723813
references.citation: Annu Rev Immunol. 2006;24:257-86
references.pmid: 16551250