title: [Virological characterization of influenza B virus in mainland China during 2011-2012].
abstract: In order to understand the prevalence and variation of influenza B viruses, the antigenic and genetic characteristics of influenza B viruses circulating in Mainland China during April, 2011 to March, 2012 were analyzed. The results showed the B Victoria lineage viruses were much more prevalent than B Yamagata lineage during this period, phylogenetic analysis showed vast majority of Victoria lineage viruses belong to genetic group 1, intra-clade reassortant between HA1 and NA gene was identified in a minor proportion of the viruses. 72.8% of the B/Victoria-lineage viruses were antigenically closely related to the vaccine strain B/Brisbane/60/2008. B Yamagata component was not included in the trivalent influenza vaccine in China during the study period, however vast majority of B Yamagata lineage viruses were antigenically and genetically closely related to the representative virus B/Hubei-Wujiagang/158/2009(97.8%) and B/Sichuan-Anyue/139/2011(85.2%) in China, reassortant between HA1 and NA was not identified in B Yamagata lineage viruses. Overall, the predominant circulating influenza B viruses in 2011-2012 season in China were matched by current influenza vaccine and the selected representative viruses were proved to represent the antigenic and genetic characteristics of the circulating viruses.
authors.affiliation: Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China. huangweijuan@cnic.org.cn
authors.forename: Wei-Juan
authors.initials: WJ
authors.lastname: Huang
authors.forename: Min-Ju
authors.initials: MJ
authors.lastname: Tan
authors.forename: Yu
authors.initials: Y
authors.lastname: Lan
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Cheng
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
authors.forename: Xi-Yan
authors.initials: XY
authors.lastname: Li
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Guo
authors.forename: He-Jiang
authors.initials: HJ
authors.lastname: Wei
authors.forename: Yao-Yao
authors.initials: YY
authors.lastname: Chen
authors.forename: Ning
authors.initials: N
authors.lastname: Xiao
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Sui
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhao
authors.forename: Da-Yan
authors.initials: DY
authors.lastname: Wang
authors.forename: Yue-Long
authors.initials: YL
authors.lastname: Shu
mesh_terms: D002681:China; D006801:Humans; D009981:Influenza B virus / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D007252:Influenza Vaccines / Q000235:genetics / Q000276:immunology; D010802:Phylogeny; D013997:Time Factors
chemical_list: D007252:Influenza Vaccines