title: Insulin-like growth factor 2 and insulin-like growth factor 2 receptor gene polymorphisms in idiopathic male infertility.
abstract: OBJECTIVE
  To test the association between insulinlike growth factor 2 (IGF2) ApaI and IGF2 receptor (IGF2R) Gly1619Arg gene polymorphisms and idiopathic male infertility.
  
  
  METHODS
  Polymerase chain reaction and restriction fragment length polymorphism methods were performed to detect the IGF2 ApaI and IGF2R Gly1619Arg genotypes in 98 Croatian men with idiopathic infertility and 113 fertile men.
  
  
  RESULTS
  There were no significant differences between patients and controls according to genotype (chi2(IGF2) = 3.46, p = 0.177; chi2(IGF2R) = 1.12, p= 0.571, respectively) and allele frequencies (chi2(IGF2) = 3.23, p = 0.072; chi2(IGF2R) = 0.99, p = 0.319, respectively). Odds ratios for recessive, dominant and codominant models and association testing with each genotype combination revealed no difference between infertile men and controls.
  
  
  CONCLUSIONS
  In this study we have shown that IGF2 ApaI and IGF2R Gly1619Arg gene polymorphisms are not associated with male infertility.
authors.affiliation: Department of Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia. nina.pereza@xnet.hr
authors.forename: Nina
authors.initials: N
authors.lastname: Pereza
authors.forename: Sasa
authors.initials: S
authors.lastname: Ostojić
authors.forename: Miljenko
authors.initials: M
authors.lastname: Kapović
authors.forename: Alena
authors.initials: A
authors.lastname: Buretić-Tomljanović
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D017523:Croatia; D005787:Gene Frequency; D005799:Genes, Dominant; D005808:Genes, Recessive; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D017527:Receptor, IGF Type 2 / Q000235:genetics*
chemical_list: D017527:Receptor, IGF Type 2; D007335:Insulin-Like Growth Factor II