title: Greater energy reduction in 6-n-propylthiouracil (PROP) super-tasters as compared to non-tasters during a lifestyle intervention.
abstract: Little is known as to how 6-n-propylthiouracil (PROP) taster status may influence changes in dietary intake in adults participating in a lifestyle intervention to assist with reducing weight. This secondary data analysis examined changes in energy, percent energy from macronutrients, and food group intake; physical activity; and body mass index (BMI) in super-tasters and non-tasters participating in two randomized controlled trials implementing a lifestyle obesity intervention. One trial focused on lowering energy density of the diet and the other trial focused on changing eating frequency. Overweight and obese participants (n = 57) who completed measures of dietary intake, physical activity, and anthropometrics at 0 and 3 months were included in the analyses. Taster status was determined at baseline: 46 non-tasters and 11 super-tasters. After controlling for condition assignment and baseline values, results indicated that a significantly greater reduction in energy intake occurred for super-tasters as compared to non-tasters (-1149 ± 561 kcal/day vs. -902 ± 660 kcal/day, p < 0.05). No other significant differences in changes in dietary intake, physical activity, or BMI were found. These results suggest that in situations of reducing energy intake, overweight and obese super-tasters may be more successful than overweight and obese non-tasters. More research is needed to understand the influence of taster-status on dietary change during a lifestyle intervention and how this may impact weight loss.
authors.affiliation: Department of Nutrition, University of Tennessee, Knoxville, TN 37996, USA. acolett1@jhmi.edu
authors.forename: Adriana
authors.initials: A
authors.lastname: Coletta
authors.forename: Jessica
authors.initials: J
authors.lastname: Bachman
authors.forename: Beverly J
authors.initials: BJ
authors.lastname: Tepper
authors.forename: Hollie A
authors.initials: HA
authors.lastname: Raynor
mesh_terms: D000328:Adult; D000368:Aged; D000963:Antimetabolites; D015992:Body Mass Index; D004038:Diet, Reducing; D004435:Eating / Q000502:physiology; D002149:Energy Intake / Q000502:physiology*; D015444:Exercise; D005260:Female; D005518:Food Preferences / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy*; D050177:Overweight / Q000178:diet therapy; D011441:Propylthiouracil; D013649:Taste / Q000502:physiology*; D013652:Taste Threshold / Q000502:physiology; D061217:Weight Reduction Programs; D055815:Young Adult
chemical_list: D000963:Antimetabolites; D011441:Propylthiouracil