title: Recent progress in satellite cell/myoblast engraftment -- relevance for therapy.
abstract: There is currently no cure for muscular dystrophies, although several promising strategies are in basic and clinical research. One such strategy is cell transplantation with satellite cells (or their myoblast progeny) to repair damaged muscle and provide dystrophin protein with the aim of preventing subsequent myofibre degeneration and repopulating the stem cell niche for future use. The present review aims to cover recent advances in satellite cell/myoblast therapy and to discuss the challenges that remain for it to become a realistic therapy.
authors.affiliation: The Dubowitz Neuromuscular Centre, UCL Institute of Child Health, London, UK.
authors.forename: Deborah
authors.initials: D
authors.lastname: Briggs
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Morgan
mesh_terms: D000818:Animals; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D009136:Muscular Dystrophies / Q000628:therapy*; D032446:Myoblasts / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology / Q000502:physiology / Q000637:transplantation*
keywords: Duchenne muscular dystrophy; cell therapy; mdx mouse; muscular dystrophy; myoblasts; satellite cells; skeletal muscle regeneration
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