title: Hsa-mir-499 rs3746444 polymorphism and cancer risk: a meta-analysis.
abstract: MicroRNAs (miRNAs) are gene regulators involved in numerous diseases including cancer, heart disease, neurological disorders, vascular abnormalities and autoimmune conditions. Although hsa-mir-499 rs3746444 polymorphism was shown to contribute to the susceptibility of multiple genes to cancer, the data have yielded conflicting results. Therefore, this meta-analysis was performed to provide a comprehensive assessment of potential association between hsa-mir-499 rs3746444 polymorphism and cancer risk. In this meta-analysis, a total of 9 articles regarding 10 eligible case-control studies in English (including 6134 cases and 7141 controls) were analyzed. No significant association between hsa-mir-499 rs3746444 polymorphism and overall cancer risk was demonstrated. However, an increased risk was observed in the subgroup of breast cancer patients (G allele vs A allele: OR = 1.10, 95% CI = 1.00-1.20; P heterogeneity = 0.114; I (2) = 53.9%) and population-based studies (G allele vs A allele: OR = 1.12, 95% CI = 1.00-1.25; P heterogeneity = 0.062; I (2) = 64.0%). The findings suggested an association between hsa-mir-499 rs3746444 polymorphism and increased risk to breast cancer.
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China;
authors.forename: Peng
authors.initials: P
authors.lastname: Zou
authors.forename: Lin
authors.initials: L
authors.lastname: Zhao
authors.forename: Haitao
authors.initials: H
authors.lastname: Xu
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Aihua
authors.initials: A
authors.lastname: Gu
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Ailin
authors.initials: A
authors.lastname: Lu
keywords: cancer; hsa-mir-499 rs3746444; meta-analysis; miRNAs; polymorphism; pre-miRNA; susceptibility
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