title: Surgically proven normocalcemic primary hyperparathyroidism: speculation of the possible role of estrogen in the etiology of this disease in premenopausal women.
abstract: We herein report a rare case of surgically proven normocalcemic primary hyperparathyroidism (NCHPT). A premenopausal 51-year-old woman was referred to our clinic because parathyroid adenoma was detected on neck ultrasonography (US). The patient's serum calcium concentration was 9.3 mg/dL and the intact parathyroid hormone (PTH) level was 128.8 pg/mL. The findings of almost all other examinations were also compatible with a diagnosis of NCHPT. Then, parathyroidectomy was performed. The serum calcium and PTH concentrations reduced significantly but remained within the normal ranges. A histological examination demonstrated parathyroid adenoma. A review of this case and the associated literature suggests that estrogen plays a significant role in the etiology of NCHPT in premenopausal women.
authors.affiliation: Department of Endocrinology, Yamashita Thyroid and Parathyroid Clinic, Japan. Tachibana@kojosen.com
authors.forename: Seigo
authors.initials: S
authors.lastname: Tachibana
authors.forename: Tadao
authors.initials: T
authors.lastname: Yokoi
authors.forename: Shinya
authors.initials: S
authors.lastname: Sato
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yanase
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamashita
mesh_terms: D002118:Calcium / Q000097:blood*; D004967:Estrogens / Q000097:blood / Q000502:physiology*; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood* / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D017697:Premenopause / Q000097:blood*
chemical_list: D004967:Estrogens; D002118:Calcium