title: [Epicardial adiposity as risk factor of coronary atherosclerosis].
abstract: OBJECTIVE
  To study effect of epicardial adiposity on risk of development and severity of coronary atherosclerosis.
  
  
  METHODS
  We registered classical metabolic risk factors (RF) and additional factors of cardiovascular risk in 138 men aged 55.47+/-9.07 years with ischemic heart disease (IHD), functional class (FC) II-III angina, and I-III degree obesity. Diagnostic coronary angiography (CAG) was performed in all patients. Thickness of epicardial fat (tEF) in millimeters was measured at transthoracic echocardiography (ECG).
  
  
  RESULTS
  Average tEF indexes were highest (10 [8; 10] mm) in the group of patients with multiple stenoses in coronary arteries (CA). According to ROC-analysis tEF appeared to be a predictor of significant coronary atherosclerosis. Its sensitivity was 80.4%, specificity - 67.6 % (cut-off value 6 mm). Epicardial adiposity was among factors associated with presence of coronary atherosclerosis (odds ratio [OR] 4.44, 95% confidence interval [CI] 2,06 to 9.59; p<0,001) along with age (OR 6.56; 95% CI 2.59 to 16.60; p=0,001), leptin (OR 3.50; 95% CI 1.46 to 8.37; p <0,001), resistin (OR 3.13; 95% CI 1.32 to 7.42; p <0,001) and waist circumference (OR 1.65; 95% CI 0.72 to 3.80; p=0.018).
authors.forename: G A
authors.initials: GA
authors.lastname: Chumakova
authors.forename: N G
authors.initials: NG
authors.lastname: Veselovskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Gritsenko
authors.forename: A A
authors.initials: AA
authors.lastname: Kozarenko
authors.forename: E A
authors.initials: EA
authors.lastname: Subbotin
mesh_terms: D050154:Adiposity; D000367:Age Factors; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D003331:Coronary Vessels / Q000503:physiopathology; D004452:Echocardiography / Q000379:methods*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D016017:Odds Ratio; D010496:Pericardium / Q000000981:diagnostic imaging / Q000473:pathology; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D008055:Lipids