title: Biomarkers of oxidative stress in women with pre-eclampsia.
abstract: OBJECTIVE
  The potential role of oxidative stress in the pathophysiology of pre-eclampsia has been reported in the literature. There are only a few studies that have investigated changes in malondialdehyde (MDA), vitamin E and total blood glutathione together in pre-eclampsia. Therefore, the aim of this study was to measure the levels of MDA, vitamin E and total glutathione as putative circulatory markers of oxidative stress for the early detection of pre-eclampsia.
  
  
  METHODS
  In this case-control study, blood samples were collected from 40 pre-eclamptic and 80 normal pregnant females at the department of obstetrics and gynecology at King Abdulaziz Medical City (Riyadh, Saudi Arabia) between February 2009 and January 2010. Circulating markers of oxidative stress were evaluated, including MDA, total glutathione and vitamin E, by high-performance liquid chromatography.
  
  
  RESULTS
  Markers of oxidative stress including serum MDA, total glutathione and vitamin E were found to be significantly different in both groups.
  
  
  CONCLUSIONS
  MDA, vitamin E and blood total glutathione are possible candidate markers to predict pre-eclampsia.
authors.affiliation: College of Medicine, Al Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia. siddiquiimra@gmail.com
authors.forename: Imran A
authors.initials: IA
authors.lastname: Siddiqui
authors.forename: Anila
authors.initials: A
authors.lastname: Jaleel
authors.forename: Hanan M F
authors.initials: HM
authors.lastname: Al'Kadri
authors.forename: Sufyan
authors.initials: S
authors.lastname: Akram
authors.forename: Waleed
authors.initials: W
authors.lastname: Tamimi
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism*; D011247:Pregnancy; D014810:Vitamin E / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014810:Vitamin E; D008315:Malondialdehyde; D005978:Glutathione