title: The role of OLR1 polymorphisms in determining the risk and prognosis of ischemic stroke in a Chinese population.
abstract: OBJECTIVE
  To explore the role of rs11053646 polymorphism of oxidized low-density lipoprotein receptor 1 (OLR-1) gene in the susceptibility and prognosis of ischemic stoke (IS).
  
  
  METHODS
  A total of 304 IS patients and 377 age and sex-matched healthy controls were recruited. Patients were followed up for 6 months for recovery evaluation of stroke. Genotyping analyses of the rs11053646 G > C polymorphisms of OLR1 gene were performed.
  
  
  RESULTS
  The genotype frequencies and alleles frequencies at rs11053646 were significantly differed between stroke subjects and control subjects (both P < 0.001). The presence of CC genotype was significantly higher in IS subjects than in controls (38% vs. 25%, P = 0.001). Similarly, the C allele carriage in IS was significantly higher than controls (59% vs. 49%, P < 0.001). Regression analysis showed the CC homozygote had a significantly increased risk for stroke (adjusted OR = 2.080; P = 0.001). The genotype of rs11053646 were not associated with the IS subtype and severity at admission, but determine the clinical outcome at 6 months after discharge from hospital.
  
  
  CONCLUSIONS
  The rs11053646 polymorphism of OLR1 gene be used as a molecular marker for the susceptibility and prognosis of IS in Chinese population.
authors.affiliation: Department of Elderly Neurology, Heilongjiang Province Hospital, Harbin, China.
authors.forename: Jianli
authors.initials: J
authors.lastname: Zhang
authors.forename: Changhao
authors.initials: C
authors.lastname: Yin
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Libo
authors.initials: L
authors.lastname: Zhao
authors.forename: HongJuan
authors.initials: H
authors.lastname: Fu
authors.forename: Jiachun
authors.initials: J
authors.lastname: Feng
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000150:complications; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011957:Receptors, Opioid / Q000235:genetics*; D020127:Recovery of Function; D012720:Severity of Illness Index; D020521:Stroke / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D000094942:Nociceptin Receptor
chemical_list: D011957:Receptors, Opioid; D000094942:Nociceptin Receptor; C000722283:OPRL1 protein, human