title: Cancer of the head and neck region in solid organ transplant recipients.
abstract: BACKGROUND
  Solid organ recipients are at an increased risk of developing various malignancies. We investigated the incidence, clinical features, and outcome of patients diagnosed with head and neck cancer after organ transplantation.
  
  
  METHODS
  A retrospective analysis was undertaken of patients who underwent solid organ transplantation (kidney, liver, lung, heart) treated at our institution from 1992 to 2010.
  
  
  RESULTS
  Of 2817 organ recipients, 175 patients (6.1%) developed 391 head and neck malignancies. Cutaneous malignancies were the most common (93%): squamous cell carcinoma (SCC; 51%) and basal cell carcinoma (BCC; 42%). The average interval from transplantation to diagnosis of head and neck malignancy was 7.3 years, with liver recipients diagnosed earlier. Eighteen percent of patients presented with an aggressive pattern of head and neck cancer, including 24% of patients with cutaneous SCC.
  
  
  CONCLUSIONS
  Organ transplantation recipients are at a higher risk to develop head and neck cancer with an aggressive behavior characterized by multiple recurrences and decreased survival.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Rabin Medical Center, Beilinson Campus, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Naomi
authors.initials: N
authors.lastname: Rabinovics
authors.forename: Aviram
authors.initials: A
authors.lastname: Mizrachi
authors.forename: Tuvia
authors.initials: T
authors.lastname: Hadar
authors.forename: Dean
authors.initials: D
authors.lastname: Ad-El
authors.forename: Raphael
authors.initials: R
authors.lastname: Feinmesser
authors.forename: Dan
authors.initials: D
authors.lastname: Guttman
authors.forename: Thomas
authors.initials: T
authors.lastname: Shpitzer
authors.forename: Gideon
authors.initials: G
authors.lastname: Bachar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D014481:United States / Q000453:epidemiology
keywords: head and neck cancer; skin; solid organ; squamous cell carcinoma; transplantation