title: Differences in body temperature variability between subjects with and without diabetes and predictive value for cardiovascular events.
abstract: BACKGROUND
  Differences in regulating factors and the clinical implications of body temperature variability (BTV) between subjects with and without diabetes have not been clarified to date.
  
  
  RESULTS
  In 66 subjects with ischemic heart disease (33 with diabetes and 33 without diabetes), BTV, the difference between the highest and lowest temperature measurements, and body temperature standard deviation (BT SD) were measured from axillary body temperature (ABT) records of 3 consecutive days and followed for 16.4±8.4 months. In subjects without diabetes BTV and BT SD were closely associated with endothelial function as evaluated on flow-mediated dilation (BTV, R=0.33, P=0.026; BT SD, R=0.41, P=0.029), whereas there was a poor association in subjects with diabetes. In the absence of an interrelationship between vascular function and thermoregulation, the contribution of inflammation to BTV was increased in subjects with diabetes (BTV, 0.59±0.21°C for C-reactive protein [CRP] <0.08 mg/dl vs. 0.79±0.28°C for CRP >0.08 mg/dl, P=0.014). Event-free survival analysis showed that in subjects with diabetes higher BT SD was associated with shorter event-free survival (log-rank P=0.012), but this relationship was not found in subjects without diabetes.
  
  
  CONCLUSIONS
  In subjects with diabetes, the interrelationship between thermoregulation and vascular function was disrupted and the effect of inflammation on thermoregulation was enhanced, so that BTV had a sufficient predictive value for cardiovascular events in diabetic subjects.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Amiya
authors.forename: Masafumi
authors.initials: M
authors.lastname: Watanabe
authors.forename: Munenori
authors.initials: M
authors.lastname: Takata
authors.forename: Shogo
authors.initials: S
authors.lastname: Watanabe
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ozeki
authors.forename: Aya
authors.initials: A
authors.lastname: Watanabe
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kawarasaki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakao
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Hosoya
authors.forename: Kazuko
authors.initials: K
authors.lastname: Omori
authors.forename: Koji
authors.initials: K
authors.lastname: Maemura
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Hirata
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000368:Aged; D001831:Body Temperature; D048909:Diabetes Complications / Q000401:mortality* / Q000503:physiopathology*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000401:mortality* / Q000503:physiopathology*; D012189:Retrospective Studies; D015996:Survival Rate