title: Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat.
abstract: Photoacoustic imaging employing molecular overtone vibration as a contrast mechanism opens a new avenue for bond-selective imaging of deep tissues. Broad use of this modality is, however, hampered by the extremely low conversion efficiency of optical parametric oscillators at the overtone transition wavelengths. To overcome such a barrier, we demonstrate the construction and use of a compact, barium nitrite crystal-based Raman laser for photoacoustic imaging of C-H overtone vibrations. Using a 5-ns Nd∶YAG laser as the pumping source, up to 21.4 mJ pulse energy at 1197 nm was generated, corresponding to a conversion efficiency of 34.8%. Using the 1197 nm pulses, three-dimensional photoacoustic imaging of intramuscular fat was demonstrated.
authors.affiliation: Purdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana 47907, USA.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Mikhail N
authors.initials: MN
authors.lastname: Slipchenko
authors.forename: Pu
authors.initials: P
authors.lastname: Wang
authors.forename: Ji-Xin
authors.initials: JX
authors.lastname: Cheng
mesh_terms: D000818:Animals; D017609:Barium Compounds / Q000737:chemistry*; D005223:Fats / Q000737:chemistry*; D006041:Goats; D053844:Lasers, Solid-State; D057054:Molecular Imaging / Q000295:instrumentation* / Q000379:methods; D009132:Muscles / Q000737:chemistry; D009573:Nitrites; D061088:Photoacoustic Techniques / Q000295:instrumentation* / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods
chemical_list: D017609:Barium Compounds; D005223:Fats; D009573:Nitrites
references.citation: Lasers Surg Med. 2006 Dec;38(10):913-9
references.pmid: 17163478
references.citation: J Biomed Opt. 2012 Jun;17(6):061209
references.pmid: 22734739
references.citation: Opt Lett. 2011 Mar 1;36(5):597-9
references.pmid: 21368919
references.citation: Opt Lett. 2012 Apr 1;37(7):1244-6
references.pmid: 22466209
references.citation: Phys Rev Lett. 2011 Jun 10;106(23):238106
references.pmid: 21770549
references.citation: Opt Express. 2010 Mar 1;18(5):4889-97
references.pmid: 20389501
references.citation: Opt Lett. 2003 Mar 15;28(6):435-7
references.pmid: 12659271
references.citation: Nat Biotechnol. 2003 Jul;21(7):803-6
references.pmid: 12808463
references.citation: Technol Cancer Res Treat. 2005 Oct;4(5):559-66
references.pmid: 16173826
references.citation: J Biophotonics. 2012 Jan;5(1):25-32
references.pmid: 22125288
references.citation: J Biomed Opt. 2006 Mar-Apr;11(2):024015
references.pmid: 16674205
references.citation: Phys Med Biol. 2004 Apr 7;49(7):1329-38
references.pmid: 15128208
references.citation: Nat Biotechnol. 2006 Jul;24(7):848-51
references.pmid: 16823374