title: Rapid, guanosine 5'-diphosphate-induced, gelation of chitosan sponges as novel injectable scaffolds for soft tissue engineering and drug delivery applications.
abstract: Novel injectable chitosan sponges based on rapid ionic crosslinking using guanosine 5'-diphosphate are introduced. The rapid gelation, high water retention, desirable physicochemical properties, soft tissue-like mechanical properties, and excellent cytocompatibility make these injectable sponges promising candidates for tissue regeneration and drug delivery applications.
authors.affiliation: Biomedical Engineering, Duff Medical Building, Room 313, McGill, Montreal, H3A 2B4, Canada.
authors.forename: Mina
authors.initials: M
authors.lastname: Mekhail
authors.forename: Jamal
authors.initials: J
authors.lastname: Daoud
authors.forename: Guillermina
authors.initials: G
authors.lastname: Almazan
authors.forename: Maryam
authors.initials: M
authors.lastname: Tabrizian
mesh_terms: D016475:3T3 Cells; D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels / Q000737:chemistry*; D006153:Guanosine Diphosphate / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering
chemical_list: D004337:Drug Carriers; D005782:Gels; D006153:Guanosine Diphosphate; D048271:Chitosan
keywords: chitosan; drug delivery; guanosine 5'-Diphosphate; injectable sponge; tissue regeneration