title: A comparative genomic study in schizophrenic and in bipolar disorder patients, based on microarray expression profiling meta-analysis.
abstract: Schizophrenia affecting almost 1% and bipolar disorder affecting almost 3%-5% of the global population constitute two severe mental disorders. The catecholaminergic and the serotonergic pathways have been proved to play an important role in the development of schizophrenia, bipolar disorder, and other related psychiatric disorders. The aim of the study was to perform and interpret the results of a comparative genomic profiling study in schizophrenic patients as well as in healthy controls and in patients with bipolar disorder and try to relate and integrate our results with an aberrant amino acid transport through cell membranes. In particular we have focused on genes and mechanisms involved in amino acid transport through cell membranes from whole genome expression profiling data. We performed bioinformatic analysis on raw data derived from four different published studies. In two studies postmortem samples from prefrontal cortices, derived from patients with bipolar disorder, schizophrenia, and control subjects, have been used. In another study we used samples from postmortem orbitofrontal cortex of bipolar subjects while the final study was performed based on raw data from a gene expression profiling dataset in the postmortem superior temporal cortex of schizophrenics. The data were downloaded from NCBI's GEO datasets.
authors.affiliation: Neuropsychiatric Research Laboratory, Department of Clinical Medicine, Örebro University, 701 82 Örebro, Sweden.
authors.forename: Marianthi
authors.initials: M
authors.lastname: Logotheti
authors.forename: Olga
authors.initials: O
authors.lastname: Papadodima
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Venizelos
authors.forename: Aristotelis
authors.initials: A
authors.lastname: Chatziioannou
authors.forename: Fragiskos
authors.initials: F
authors.lastname: Kolisis
mesh_terms: D026905:Amino Acid Transport Systems / Q000235:genetics / Q000378:metabolism*; D000596:Amino Acids / Q000235:genetics / Q000378:metabolism*; D001714:Bipolar Disorder / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism*; D002874:Chromosome Mapping / Q000379:methods; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D015995:Prevalence; D020543:Proteome / Q000378:metabolism; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism*
chemical_list: D026905:Amino Acid Transport Systems; D000596:Amino Acids; D020543:Proteome
references.citation: Neuropsychopharmacology. 2011 Aug;36(9):1921-31
references.pmid: 21593732
references.citation: Encephale. 1991 May-Jun;17(3):197-201
references.pmid: 1864253
references.citation: Can J Psychiatry. 2002 Mar;47(2):135-48
references.pmid: 11926075
references.citation: Mol Psychiatry. 2006 Oct;11(10):965-78
references.pmid: 16894394
references.citation: Prostaglandins Leukot Essent Fatty Acids. 1996 Aug;55(1-2):59-64
references.pmid: 8888124
references.citation: Mol Psychiatry. 2004 Nov;9(11):1007-29
references.pmid: 15314610
references.citation: J Psychiatr Res. 2011 Apr;45(4):519-25
references.pmid: 20728902
references.citation: Int J Neuropsychopharmacol. 2006 Apr;9(2):247-55
references.pmid: 15972118
references.citation: Schizophr Res. 2005 Apr 1;74(1):81-9
references.pmid: 15694757
references.citation: Genome Biol. 2011 Jun 22;12(6):R57
references.pmid: 21696594
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2003 May;27(3):431-40
references.pmid: 12691778
references.citation: Bipolar Disord. 2009 Nov;11(7):726-34
references.pmid: 19839997
references.citation: Schizophr Res. 1998 Feb 9;29(3):269-74
references.pmid: 9516668
references.citation: Nephrol Dial Transplant. 1998 Dec;13(12):3147-52
references.pmid: 9870480
references.citation: J Neurosci Res. 2011 Aug;89(8):1218-27
references.pmid: 21538462
references.citation: Neurosci Lett. 2009 Jun 19;457(1):49-52
references.pmid: 19429160
references.citation: Science. 1990 Dec 14;250(4987):1541-6
references.pmid: 2274785
references.citation: Depress Anxiety. 1997;5(2):53-65
references.pmid: 9262935
references.citation: Science. 2002 Apr 26;296(5568):692-5
references.pmid: 11976442
references.citation: Mol Psychiatry. 2008 Feb;13(2):147-61
references.pmid: 17471287
references.citation: Nucleic Acids Res. 2009 Jan;37(Database issue):D32-6
references.pmid: 18927115
references.citation: Adv Bioinformatics. 2012;2012:453513
references.pmid: 23193398
references.citation: Front Neurosci. 2011 Jan 26;5:8
references.pmid: 21293737
references.citation: Hum Mol Genet. 2005 Jan 15;14(2):241-53
references.pmid: 15563509
references.citation: Schizophr Res. 1999 Nov 9;40(1):37-42
references.pmid: 10541005
references.citation: Mol Psychiatry. 2007 Sep;12(9):815-25
references.pmid: 17440432
references.citation: Prog Neurobiol. 2005 Apr;75(6):367-90
references.pmid: 15927345
references.citation: Schizophr Res. 1998 Apr 10;30(3):193-208
references.pmid: 9589514
references.citation: Altern Med Rev. 2004 Jun;9(2):107-35
references.pmid: 15253674
references.citation: Prostaglandins Leukot Essent Fatty Acids. 1996 Aug;55(1-2):3-7
references.pmid: 8888116
references.citation: Nucleic Acids Res. 2009 Jan;37(Database issue):D885-90
references.pmid: 18940857
references.citation: Biochem J. 2003 Jul 1;373(Pt 1):1-18
references.pmid: 12879880
references.citation: BMC Psychiatry. 2008 Nov 07;8:87
references.pmid: 18992145
references.citation: Neurosci Lett. 2006 Jan 30;393(2-3):211-5
references.pmid: 16274928
references.citation: Mol Neurobiol. 2002 Oct-Dec;26(2-3):369-88
references.pmid: 12428765
references.citation: Pflugers Arch. 2002 Jul;444(4):457-66
references.pmid: 12136264
references.citation: Neurosci Lett. 2008 Mar 21;434(1):56-60
references.pmid: 18262359
references.citation: Mol Psychiatry. 2004 Apr;9(4):406-16
references.pmid: 14743183
references.citation: IEEE Trans Biomed Eng. 2011 Dec;58(12):3522-7
references.pmid: 21846603
references.citation: Int J Tryptophan Res. 2011;4:19-27
references.pmid: 22084600
references.citation: Biol Psychiatry. 2000 Jun 1;47(11):991-9
references.pmid: 10838067
references.citation: J Clin Psychiatry. 2000;61 Supp 13:42-57
references.pmid: 11153812
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):878-88
references.pmid: 16005134
references.citation: Arch Gen Psychiatry. 2001 Oct;58(10):953-8
references.pmid: 11576034
references.citation: BMC Bioinformatics. 2009 Oct 27;10:354
references.pmid: 19860866
references.citation: Prostaglandins Leukot Essent Fatty Acids. 1999 Apr;60(4):217-34
references.pmid: 10397403