title: Sericins exhibit ROS-scavenging, anti-tyrosinase, anti-elastase, and in vitro immunomodulatory activities.
abstract: Some biological properties of Bombyx mori sericins from twenty strains were investigated, fourteen fed with artificial diet, two with fresh mulberry leaves and four with both diets. Sericin exhibited ROS-scavenging, anti-tyrosinase and anti-elastase properties, the strain significantly influenced these properties, while diet only influenced the anti-tyrosinase activity. Sericins were clustered into 5 groups and one sericin from each group was further studied: sericins showed anti-proliferative activity on in vitro stimulated peripheral blood mononuclear cells; some strains decreased in vitro secretion of IFNγ, while no effects were observed on TNFα and IL10 release. Therefore, a mixture of sericins extracted from the most promising strains may be useful for dermatological and cosmetic use.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università di Pavia, Pavia, Italy.
authors.forename: Theodora
authors.initials: T
authors.lastname: Chlapanidas
authors.forename: Silvio
authors.initials: S
authors.lastname: Faragò
authors.forename: Giulia
authors.initials: G
authors.lastname: Lucconi
authors.forename: Sara
authors.initials: S
authors.lastname: Perteghella
authors.forename: Marta
authors.initials: M
authors.lastname: Galuzzi
authors.forename: Melissa
authors.initials: M
authors.lastname: Mantelli
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Avanzini
authors.forename: Marta Cecilia
authors.initials: MC
authors.lastname: Tosca
authors.forename: Mario
authors.initials: M
authors.lastname: Marazzi
authors.forename: Daniele
authors.initials: D
authors.lastname: Vigo
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Torre
authors.forename: Massimo
authors.initials: M
authors.lastname: Faustini
mesh_terms: D000818:Animals; D012831:Bombyx / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D004032:Diet; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology; D005656:Fungal Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D006801:Humans; D007155:Immunologic Factors / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000502:physiology; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000737:chemistry; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D010316:Particle Size; D011208:Powders / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry*; D047030:Sericins / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology; D013045:Species Specificity; D017550:Spectroscopy, Fourier Transform Infrared; D034421:Sus scrofa
chemical_list: D016207:Cytokines; D016166:Free Radical Scavengers; D005656:Fungal Proteins; D007155:Immunologic Factors; D011208:Powders; D017382:Reactive Oxygen Species; D047030:Sericins; D014442:Monophenol Monooxygenase; D010196:Pancreatic Elastase