title: [Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
abstract: Several epidemiological studies suggest that pesticides could lead to neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Among pesticides, insecticides appear more neurotoxic than others but the neurotoxic mechanisms leading to adverse health effects remain unclear. The currently used pesticides such as rotenone and paraquat could disrupt mitochondrial bioenergetic function, reactive oxygen metabolism, redox function and promote α-synuclein aggregation. In addition, recent studies demonstrate that genetic susceptibility to Parkinson's disease could monitor pesticide susceptibility, as demonstrated for polymorphisms in pesticide metabolizing enzymes that are involved in organophosphorus sensitivity.
authors.affiliation: Laboratoire récepteurs et canaux ioniques membranaires, UPRES EA 2647-USC INRA 1330, Université d'Angers, UFR sciences, 2, boulevard Lavoisier, 49045 Angers, France. steeve.thany@univ-angers.fr
authors.forename: Steeve H
authors.initials: SH
authors.lastname: Thany
authors.forename: Pascal
authors.initials: P
authors.lastname: Reynier
authors.forename: Guy
authors.initials: G
authors.lastname: Lenaers
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced; D000818:Animals; D020022:Genetic Predisposition to Disease; D006801:Humans; D007306:Insecticides / Q000633:toxicity; D008928:Mitochondria / Q000187:drug effects; D019636:Neurodegenerative Diseases / Q000139:chemically induced*; D010269:Paraquat / Q000633:toxicity; D010300:Parkinson Disease / Q000235:genetics; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000235:genetics; D010575:Pesticides / Q000633:toxicity*; D012402:Rotenone / Q000633:toxicity; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D007306:Insecticides; D010575:Pesticides; D051844:alpha-Synuclein; D012402:Rotenone; D010269:Paraquat