title: Anti-convulsant action and amelioration of oxidative stress by Glycyrrhiza glabra root extract in pentylenetetrazole- induced seizure in albino rats.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the anti-convulsant potential of aqueous and ethanol e xtract of Glycyrrhiza glabra (AEGG and EEGG) and its action on markers of oxidant stress in albino rats.
  
  
  METHODS
  The aqueous and ethanol extract of Glycyrrhiza glabra was tested at three doses viz. 100, 200, and 400 mg/kg i.p. for its anti-convulsant activity using pentylenetetrazole (PTZ)-induced seizure in rat. The effect of EEGG (400 mg/kg, i.p.) on oxidative stress markers like malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) of rat brain tissue homogenate was tested.
  
  
  RESULTS
  The onset of seizure was delayed (P < 0.01) by all the three doses of EEGG, but the duration of convulsion was reduced (P < 0.01) only in higher dose level (200 and 400 mg/ kg), whereas AEGG up to 400 mg/kg did not alter any of the parameters significantly. Biochemical analysis of rat brain tissue revealed that MDA was increased (P < 0.01), whereas SOD and CAT were decreased (P < 0.01) in PTZ-induced seizure rat, whereas pre-treatment with EEGG (400 mg/kg) decreased (P < 0.01) the MDA and increased (P < 0.01) both SOD and CAT, indicating attenuation of lipid peroxidation due to increase in antioxidant enzymes.
  
  
  CONCLUSIONS
  The results demonstrated that EEGG poses anti-convulsant potential and ameliorates ROS induced neuronal damage in PTZ-induced seizure.
authors.affiliation: Department of Pharmacology, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur, Odisha, India.
authors.forename: Bimalendu
authors.initials: B
authors.lastname: Chowdhury
authors.forename: Subrat K
authors.initials: SK
authors.lastname: Bhattamisra
authors.forename: Mangala C
authors.initials: MC
authors.lastname: Das
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006035:Glycyrrhiza / Q000737:chemistry*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010433:Pentylenetetrazole / Q000633:toxicity; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D015415:Biomarkers; D010936:Plant Extracts; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D010433:Pentylenetetrazole
keywords: Catalase; Glycyrrhiza glabra; malondialdehyde; pentylenetetrazole; seizures; superoxide dismutase
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