title: [Perioperative management of a child with central diabetes insipidus who underwent two surgeries before and after desmopressin administration].
abstract: A 14-year-old girl weighing 32 kg was diagnosed with suprasellar tumor causing hydrocephalus, hypothyroidism, adrenal dysfunction and central diabetes insipidus. She was treated with levothyroxine and hydrocortisone and urged to take fluid to replace urine. She was scheduled to undergo ventricular drainage to relieve hydrocephalus prior to tumor resection. For the first surgery, desmopressin was not started and urine output reached 4,000 to 6,000 ml x day(-1), urine osmolality 64 mOsm x l(-1) and urine specific gravity 1.002. Anesthesia was induced with sevoflurane and maintained with propofol and remifentanil. Maintenance fluid was with acetated Ringer's solution and urine loss was replaced with 5% dextrose. Bradycardia and hypotension occurred after intubation, which was treated with volume load. Infusion volume was 750 ml and urine output was 1100 ml during 133 min of anesthesia. Postoperative day 1 nasal desmopressin was started. Ten days later, partial tumor resection was performed. Anesthesia was induced with propofol and fentanyl and maintained with sevoflurane and remifentanil. Infusion volume was 610 ml, urine output 380 ml, and blood loss 151 ml during 344 min of anesthesia. Hemodynamic parameters were stable throughout the procedure. Pathology of the tumor was revealed to be germinoma. Bradycardia and hypotension experienced during the first surgery was suspected to be caused by preoperative hypovolemia brought by polyuria. Desmopressin was proved to be effective to treat excessive urine output and to maintain good perioperative water balance.
authors.affiliation: Department of Anesthesia and Intensive Care, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi 594-1101.
authors.forename: Keiji
authors.initials: K
authors.lastname: Kiriyama
authors.forename: Kazuya
authors.initials: K
authors.lastname: Tachibana
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Nishimura
authors.forename: Muneyuki
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Kinouchi
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General / Q000379:methods*; D050034:Antidiuretic Agents / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000601:surgery*; D002557:Cerebrospinal Fluid Shunts; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage*; D020790:Diabetes Insipidus, Neurogenic / Q000150:complications* / Q000209:etiology; D005260:Female; D018237:Germinoma / Q000601:surgery*; D006801:Humans; D019990:Perioperative Care / Q000379:methods*
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin