title: Topiramate for abnormal eating behaviour in frontotemporal dementia.
abstract: Topiramate is a sulfamate-substituted monosaccharide anticonvulsant that is associated with anorexia and weight loss and has been used to treat binge eating disorder and bulimia nervosa. This report describes a man with frontotemporal dementia, behavioural variant, associated with abnormal eating behaviour which appeared to respond to topiramate. We review the physiological basis of abnormal eating behaviour in frontotemporal dementia and explore possible mechanisms of action by which topiramate may modify eating behaviour in this condition.
authors.affiliation: Neuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, Australia.
authors.forename: Colin
authors.initials: C
authors.lastname: Singam
authors.forename: Mark
authors.initials: M
authors.lastname: Walterfang
authors.forename: Ramon
authors.initials: R
authors.lastname: Mocellin
authors.forename: Andrew
authors.initials: A
authors.lastname: Evans
authors.forename: Dennis
authors.initials: D
authors.lastname: Velakoulis
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D056912:Binge-Eating Disorder / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D057180:Frontotemporal Dementia / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose