title: Foxp3 (-/ATT) polymorphism contributes to the susceptibility of preeclampsia.
abstract: OBJECTIVE
  To evaluate the potential influence of Foxp3 polymorphism on preeclampsia (PE) susceptibility, we conducted a case-control study in Han Chinese women.
  
  
  METHODS
  Foxp3 genotyping was determined by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 156 PE patients and 252 age-frequency matched controls. Immunohistochemical staining was used to detect the expression of Foxp3 specific transcription factor in 30 PE and 30 normal pregnant women.
  
  
  RESULTS
  The positive rate of Foxp3 expression in PE (26.67%) was significant difference from that in normal control (63.33%, P<0.05). The frequency of Foxp3-6054 TT genotype was significantly lower in PE patient than that in control. No significant difference was found in Foxp3-3279 genotypes between PE and control, as well as for the variant allele. The frequency of Foxp3-6054A/-3279C haplotype in PE was significantly higher than that in control (P<0.01), while the frequency of Foxp3 6054T/-3279C haplotype was significantly lower in PE patient than that in control (P<0.01).
  
  
  CONCLUSIONS
  Our findings suggest that the immune suppression function in PE patients is weakened, which may result in the occurrence of PE. Foxp3 polymorphism (rs5902434) may be a potential contributor for the development of PE in Han Chinese women.
authors.affiliation: Medical College of University of South, Guangzhou, China. Chen_ximing@hotmail.com
authors.forename: Ximing
authors.initials: X
authors.lastname: Chen
authors.forename: Ting
authors.initials: T
authors.lastname: Gan
authors.forename: Zhiqiong
authors.initials: Z
authors.lastname: Liao
authors.forename: Shengqiang
authors.initials: S
authors.lastname: Chen
authors.forename: Jianhua
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D001483:Base Sequence; D016022:Case-Control Studies; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D011247:Pregnancy
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors
references.citation: Biochem Soc Trans. 2011 Dec;39(6):1619-27
references.pmid: 22103497
references.citation: Am J Obstet Gynecol. 2012 Feb;206(2):165.e1-6
references.pmid: 22000667
references.citation: Acta Obstet Gynecol Scand. 2008;87(11):1229-33
references.pmid: 19016357
references.citation: Lupus. 2011 Feb;20(2):137-43
references.pmid: 21078762
references.citation: Hypertension. 2010 May;55(5):1246-53
references.pmid: 20351341
references.citation: Fertil Steril. 2011 Jun;95(7):2223-7
references.pmid: 21481380
references.citation: Scand J Immunol. 2013 Feb;77(2):104-8
references.pmid: 22809231
references.citation: J Immunol. 2009 Dec 1;183(11):7023-30
references.pmid: 19915051
references.citation: J Cell Mol Med. 2010 Jan;14(1-2):226-41
references.pmid: 20414968
references.citation: J Pregnancy. 2012;2012:298343
references.pmid: 22523688
references.citation: J Reprod Immunol. 2011 Sep;91(1-2):76-82
references.pmid: 21782252
references.citation: Ann N Y Acad Sci. 2005 Jun;1051:218-28
references.pmid: 16126962
references.citation: Iran J Immunol. 2011 Dec;8(4):218-25
references.pmid: 22201619
references.citation: Immunity. 2005 Mar;22(3):329-41
references.pmid: 15780990
references.citation: Hum Immunol. 2011 Oct;72(10):926-9
references.pmid: 21763379
references.citation: Clin Dev Immunol. 2012;2012:896458
references.pmid: 21876709