title: Juvenile hormone esterase: biochemistry and structure.
abstract: Normal insect development requires a precisely timed, precipitous drop in hemolymph juvenile hormone (JH) titer. This drop occurs through a coordinated halt in JH biosynthesis and increase in JH metabolism. In many species, JH esterase (JHE) is critical for metabolism of the resonance-stabilized methyl ester of JH. JHE metabolizes JH with a highkcat/KMratio that results primarily from an exceptionally lowKM. Here we review the biochemistry and structure of authentic and recombinant JHEs from six insect orders, and present updated diagnostic criteria that help to distinguish JHEs from other carboxylesterases. The use of a JHE-encoding gene to improve the insecticidal efficacy of biopesticides is also discussed.
authors.affiliation: Department of Entomology and UCD Cancer Center, University of California, Davis, California 95616, USA.
authors.forename: Shizuo G
authors.initials: SG
authors.lastname: Kamita
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Hammock
keywords: JH; carboxylesterase; inhibitor; juvenile hormone esterase (JHE)
references.citation: Insect Biochem Mol Biol. 2010 Jan;40(1):1-16
references.pmid: 20005949
references.citation: Chem Res Toxicol. 1990 Jul-Aug;3(4):325-32
references.pmid: 2133080
references.citation: Comp Biochem Physiol B Biochem Mol Biol. 2008 May;150(1):33-44
references.pmid: 18308604
references.citation: Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6007-12
references.pmid: 9177159
references.citation: Insect Biochem Mol Biol. 2003 Dec;33(12):1261-73
references.pmid: 14599498
references.citation: Arch Insect Biochem Physiol. 1997;34(3):275-86
references.pmid: 9055438
references.citation: Zoolog Sci. 2004 Jan;21(1):53-62
references.pmid: 14745104
references.citation: Biochemistry. 2010 May 4;49(17):3733-42
references.pmid: 20307057
references.citation: Insect Biochem Mol Biol. 2007 May;37(5):497-505
references.pmid: 17456444
references.citation: Biochem J. 1994 Sep 15;302 ( Pt 3):827-35
references.pmid: 7945209
references.citation: Adv Virus Res. 2006;68:323-60
references.pmid: 16997016
references.citation: Insect Biochem Mol Biol. 2007 Jun;37(6):540-9
references.pmid: 17517331
references.citation: Biol Bull. 1975 Dec;149(3):506-21
references.pmid: 1203335
references.citation: J Insect Physiol. 2008 Jan;54(1):255-64
references.pmid: 18022634
references.citation: J Am Mosq Control Assoc. 2007;23(2 Suppl):225-39
references.pmid: 17853608
references.citation: Arch Insect Biochem Physiol. 1997;35(3):261-77
references.pmid: 9177132
references.citation: J Mol Biol. 2004 Jul 16;340(4):783-95
references.pmid: 15223320
references.citation: Arch Insect Biochem Physiol. 2002 Jan;49(1):41-55
references.pmid: 11754093
references.citation: J Insect Physiol. 1975 Apr;21(4):873-87
references.pmid: 1127251
references.citation: Insect Biochem Mol Biol. 2007 Aug;37(8):829-37
references.pmid: 17628281
references.citation: Org Lett. 2009 Nov 19;11(22):5234-7
references.pmid: 19863071
references.citation: Insect Biochem Mol Biol. 2000 Aug-Sep;30(8-9):617-44
references.pmid: 10876106
references.citation: J Invertebr Pathol. 1999 Mar;73(2):234-6
references.pmid: 10066407
references.citation: J Insect Physiol. 2008 Dec;54(12):1495-502
references.pmid: 18804476
references.citation: J Insect Physiol. 2005 Apr;51(4):393-400
references.pmid: 15890182
references.citation: Mol Cell Endocrinol. 1999 Feb 25;148(1-2):95-108
references.pmid: 10221775
references.citation: Insect Mol Biol. 1998 Nov;7(4):327-36
references.pmid: 9723870
references.citation: Tissue Cell. 1992;24(2):267-82
references.pmid: 1589874
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11751-6
references.pmid: 16087883
references.citation: Science. 1991 Aug 23;253(5022):872-9
references.pmid: 1678899
references.citation: Insect Biochem Mol Biol. 2001 Dec;32(1):57-66
references.pmid: 11719069
references.citation: J Biol Chem. 2002 Jun 14;277(24):21874-81
references.pmid: 11909871
references.citation: Biochemistry. 2006 Apr 4;45(13):4045-57
references.pmid: 16566578
references.citation: Proteins. 1999 Feb 1;34(2):184-96
references.pmid: 10022354
references.citation: Mol Biol Evol. 2007 Aug;24(8):1596-9
references.pmid: 17488738
references.citation: J Biol Chem. 2002 Jun 14;277(24):21882-90
references.pmid: 11909870
references.citation: J Insect Physiol. 2000 Jan;46(1):59-68
references.pmid: 12770259
references.citation: J Insect Physiol. 2008 Sep;54(9):1323-31
references.pmid: 18634793
references.citation: Insect Biochem Mol Biol. 2010 Feb;40(2):100-12
references.pmid: 20060470
references.citation: J Insect Physiol. 2008 Jun;54(6):895-901
references.pmid: 18355835
references.citation: Insect Biochem Mol Biol. 2007 Aug;37(8):761-70
references.pmid: 17628276
references.citation: Insect Biochem Mol Biol. 2001 Apr 27;31(6-7):513-20
references.pmid: 11267890
references.citation: J Insect Physiol. 2004 Feb-Mar;50(2-3):111-21
references.pmid: 15019512
references.citation: Insect Biochem Mol Biol. 2003 May;33(5):477-87
references.pmid: 12706627
references.citation: Arch Insect Biochem Physiol. 1998;37(4):305-14
references.pmid: 9543711
references.citation: Arch Biochem Biophys. 1984 Feb 1;228(2):639-45
references.pmid: 6696451
references.citation: J Biol Chem. 1989 Jul 25;264(21):12419-25
references.pmid: 2745451
references.citation: Insect Biochem Mol Biol. 2007 Dec;37(12):1359-65
references.pmid: 17967354
references.citation: Int J Biochem. 1992 Dec;24(12):1933-41
references.pmid: 1473606
references.citation: Arch Biochem Biophys. 1993 Dec;307(2):231-41
references.pmid: 8274008
references.citation: Insect Biochem Mol Biol. 1998 Jul;28(7):501-15
references.pmid: 9718682
references.citation: Science. 1986 Sep 5;233(4768):1073-6
references.pmid: 3738525
references.citation: Bioorg Med Chem. 2008 Feb 15;16(4):2114-30
references.pmid: 18023188
references.citation: J Med Chem. 2002 Dec 5;45(25):5576-93
references.pmid: 12459025
references.citation: Insect Mol Biol. 2010 Aug;19(4):527-35
references.pmid: 20522120
references.citation: Insect Biochem Mol Biol. 2003 Mar;33(3):317-29
references.pmid: 12609517
references.citation: Insect Mol Biol. 2006 Oct;15(5):615-36
references.pmid: 17069637
references.citation: Insect Biochem Mol Biol. 1997 Nov;27(11):919-28
references.pmid: 9501416
references.citation: Biosci Biotechnol Biochem. 2000 Aug;64(8):1681-7
references.pmid: 10993156
references.citation: Annu Rev Entomol. 1999;44:257-89
references.pmid: 15012374
references.citation: Insect Biochem Mol Biol. 2002 Jun;32(6):627-35
references.pmid: 12020837