title: Is hyponatremia mistreated? Challenging the current paradigm.
abstract: BACKGROUND
  Hyponatremia is a common but often mistreated clinical situation in the ICU. This often requires the physician to identify the underlying problem, adrenal insufficiency. However, by the textbook, the current treatment always involves sodium chloride supplementation to hyponatremic patients, either intravenous or oral intake. We hypothesize that the mechanism behind most hyponatremia is most likely to be the sodium and water redistribution from the serum to the cells or the interstitial spaces due to the insufficient cortical steroid, not the sodium deficiency. As we have no reason to believe the patients have lost that much sodium which caused hyponatremia. Therefore, giving this type of hyponatremic patients (adrenal insufficient) sodium chloride is always ineffective and sometimes catastrophic.
  
  
  METHODS
  We discuss the possible mechanism for hyponatremia in critically ill/post surgery patients who are mostly likely to be adrenal insufficient rather than absolute sodium deficiency. In combination with many other common but unexplainable symptoms such as nausea, vomiting, obstinate diarrhea, hypotension and coma in the ICU, it is highly likely that hyponatremia is a condition which reflects the patients' adrenal function. The evidence supporting our hypothesis is that, (1) the serum sodium level does not always respond well to sodium supplementation therapy; (2) those aforementioned symptoms alleviated simultaneously with the serum sodium level returned to normal after the hydrocortisone or prednisone was administered without any oral/intravenous sodium supplementation; (3) patient with an elevated serum/urine cortisol level suffers from aforementioned unexplainable symptoms does not warrant him being adrenal sufficient. If the patient also has hyponatremia, the diagnosis can be considered as "relative adrenal insufficiency" and the patient would respond well to hydrocortisone or prednisone therapy.
  
  
  CONCLUSIONS
  We hypothesize that hyponatremia without significant loss of sodium can be used as an indicator to monitor the patients' adrenal function regardless of the serum/urine cortisol level. Furthermore, we propose a novel approach toward hyponatremia treatment in critically ill patients would be hydrocortisone or prednisone therapy depending on the circumstances.
authors.affiliation: Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Rd., Tianjin 300052, China. yiweiqiu@hotmail.com
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Qiu
authors.forename: Mingcai
authors.initials: M
authors.lastname: Qiu
mesh_terms: D000309:Adrenal Insufficiency / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003422:Critical Care / Q000379:methods; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000627:therapeutic use / Q000652:urine; D007010:Hyponatremia / Q000188:drug therapy* / Q000209:etiology*; D007362:Intensive Care Units; D011241:Prednisone / Q000627:therapeutic use; D012964:Sodium / Q000097:blood / Q000378:metabolism*; D012965:Sodium Chloride / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D012965:Sodium Chloride; D012964:Sodium; D011241:Prednisone; D006854:Hydrocortisone