title: Phenol composition, cytotoxic and anti-kinetoplastidae activities of Lygodium venustum SW. (Lygodiaceae).
abstract: The search for new therapeutic agents has been a constant for the treatment of diseases such as leishmaniasis and Chagas disease. Most drugs used have side effects, justifying the need to evaluate the cytotoxicity of the tested products for candidates to new drugs. In this study, the bioactivity of Lygodium venustum, a cosmopolitan fern of Lygodiaceae, was assessed about their leishmanicidal and trypanocidal potential. The better activity was observed using methanol fraction, with inhibition percentage of 63% and 68% for promastigotes and epimastigotes, respectively, at a concentration of 500 μg/mL. The ethyl acetate and methanol fractions demonstrated a higher cytotoxic potential. This was the first report of leishmanicidal, trypanocidal and cytotoxic activities to L. venustum.
authors.affiliation: Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, Brazil.
authors.forename: Maria F B
authors.initials: MF
authors.lastname: Morais-Braga
authors.forename: Teógenes M
authors.initials: TM
authors.lastname: Souza
authors.forename: Karla K A
authors.initials: KK
authors.lastname: Santos
authors.forename: Gláucia M M
authors.initials: GM
authors.lastname: Guedes
authors.forename: Jacqueline C
authors.initials: JC
authors.lastname: Andrade
authors.forename: Celeste
authors.initials: C
authors.lastname: Vega
authors.forename: Miriam
authors.initials: M
authors.lastname: Rolón
authors.forename: José G M
authors.initials: JG
authors.lastname: Costa
authors.forename: Antonio A F
authors.initials: AA
authors.lastname: Saraiva
authors.forename: Henrique D M
authors.initials: HD
authors.lastname: Coutinho
mesh_terms: D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029624:Ferns / Q000737:chemistry*; D007892:Leishmania braziliensis / Q000187:drug effects*; D010636:Phenols / Q000032:analysis; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D010636:Phenols; D010936:Plant Extracts; D014344:Trypanocidal Agents