title: Squamous cell carcinomas in patients with Fanconi anemia and dyskeratosis congenita: a search for human papillomavirus.
abstract: Patients with Fanconi anemia (FA) and dyskeratosis congenita (DC) are at high risk of head and neck squamous cell carcinomas (HNSCC) and anogenital squamous cell carcinomas (SCC). In the general population, these sites (particularly oropharyngeal SCC) may be associated with infection with human papillomavirus (HPV). In FA and DC, however, the majority of HNSCC occur in the oral cavity. We investigated the HPV status of HNSCC and vulvar SCC from nine patients with FA and four with DC using a very sensitive PCR assay, and found HPV16 DNA in only a single vulvar tumor from one patient with FA, and in none of the HNSCC. These results suggest that HPV may not be the cause of SCC in patients with FA or DC, and that vaccination may not reduce the incidence of HNSCC in these patients.
authors.affiliation: Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. alterb@mail.nih.gov
authors.forename: Blanche P
authors.initials: BP
authors.lastname: Alter
authors.forename: Neelam
authors.initials: N
authors.lastname: Giri
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Savage
authors.forename: Wim G V
authors.initials: WG
authors.lastname: Quint
authors.forename: Maurits N C
authors.initials: MN
authors.lastname: de Koning
authors.forename: Mark
authors.initials: M
authors.lastname: Schiffman
mesh_terms: D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D019871:Dyskeratosis Congenita / Q000150:complications*; D005199:Fanconi Anemia / Q000097:blood* / Q000150:complications; D005260:Female; D006258:Head and Neck Neoplasms / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: Fanconi anemia; dyskeratosis congenita; human papillomavirus; squamous cell carcinoma
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):467-75
references.pmid: 15734974
references.citation: Mod Pathol. 2008 Mar;21(3):334-44
references.pmid: 18192968
references.citation: Lancet. 2007 Sep 8;370(9590):890-907
references.pmid: 17826171
references.citation: Br J Haematol. 2010 Jul;150(2):179-88
references.pmid: 20507306
references.citation: Head Neck Pathol. 2012 Jul;6 Suppl 1:S16-24
references.pmid: 22782220
references.citation: J Clin Microbiol. 2013 Apr;51(4):1171-8
references.pmid: 23363835
references.citation: J Natl Cancer Inst. 2003 Nov 19;95(22):1718-21
references.pmid: 14625263
references.citation: Cancer. 2008 Nov 15;113(10 Suppl):3036-46
references.pmid: 18980286
references.citation: Oral Oncol. 2013 Jan;49(1):1-8
references.pmid: 22841678
references.citation: J Clin Microbiol. 2006 Sep;44(9):3292-8
references.pmid: 16954263
references.citation: Blood Rev. 2010 May;24(3):101-22
references.pmid: 20417588
references.citation: Sex Transm Dis. 2009 Nov;36(11):675-9
references.pmid: 19773679
references.citation: J Natl Cancer Inst. 2008 Nov 19;100(22):1649-53
references.pmid: 19001603