title: An Emerging Role for PI5P in T Cell Biology.
abstract: Phosphoinositides are critical regulators in cell biology. Phosphatidylinositol 4,5-bisphosphate, also known as PI(4,5)P2 or PIP2, was the first variety of phosphoinositide to enter in the T cell signaling scene. Phosphatidylinositol bis-phosphates are the substrates for different types of enzymes such as phospholipases C (β and γ isoforms) and phosphoinositide 3-kinases (PI3K class IA and IB) that are largely involved in signal transduction. However until recently, only a few studies highlighted phosphatidylinositol monophosphates as signaling molecules. This was mostly due to the difficulty of detection of some of these phosphoinositides, such as phosphatidylinositol 5-phosphate, also known as PI5P. Some compelling evidence argues for a role of PI5P in cell signaling and/or cell trafficking. Recently, we reported the detection of a PI5P increase upon TCR triggering. Here, we describe the current knowledge of the role of PI5P in T cell signaling. The future challenges that will be important to achieve in order to fully characterize the role of PI5P in T cell biology, will be discussed.
authors.affiliation: Immunology and Cancer, UMR7258, CNRS, Centre de Recherche en Cancerologie de Marseille Marseille, France ; Immunology and Cancer, U1068, INSERM, Centre de Recherche en Cancerologie de Marseille Marseille, France ; Immunology and Cancer, Institut Paoli-Calmettes Marseille, France ; Centre de Recherche en Cancerologie de Marseille, Aix-Marseille University Marseille, France.
authors.forename: Jacques A
authors.initials: JA
authors.lastname: Nunès
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Guittard
keywords: Dok proteins; PI5P; PtdIns5P; T cell signaling; phosphoinositide
references.citation: Hum Mol Genet. 2002 Jun 15;11(13):1569-79
references.pmid: 12045210
references.citation: Sci Signal. 2011 Sep 20;4(191):ra61
references.pmid: 21934107
references.citation: Nat Rev Mol Cell Biol. 2008 Feb;9(2):99-111
references.pmid: 18216767
references.citation: Nat Immunol. 2009 Feb;10(2):185-94
references.pmid: 19136961
references.citation: J Biol Chem. 2002 Oct 25;277(43):40420-7
references.pmid: 12171928
references.citation: Eur J Immunol. 1992 Jan;22(1):45-9
references.pmid: 1346114
references.citation: Biochem J. 2012 Mar 15;442(3):465-81
references.pmid: 22364281
references.citation: Nat Rev Immunol. 2008 Sep;8(9):699-712
references.pmid: 18728635
references.citation: EMBO J. 2002 Oct 1;21(19):5069-78
references.pmid: 12356723
references.citation: Mol Cell. 2006 Sep 1;23(5):685-95
references.pmid: 16949365
references.citation: Genes Immun. 2003 Jan;4(1):40-5
references.pmid: 12595900
references.citation: J Cell Sci. 2006 Jul 15;119(Pt 14):2953-9
references.pmid: 16787938
references.citation: Blood. 2008 Apr 15;111(8):4165-72
references.pmid: 18073347
references.citation: J Immunol. 2009 Jun 15;182(12):7681-9
references.pmid: 19494292
references.citation: Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46
references.pmid: 22621786
references.citation: J Immunol. 2009 Apr 1;182(7):3974-8
references.pmid: 19299694
references.citation: J Exp Med. 2007 May 14;204(5):1167-79
references.pmid: 17485513
references.citation: Nat Genet. 1996 Jun;13(2):175-82
references.pmid: 8640223
references.citation: Cell. 2003 Jul 11;114(1):99-111
references.pmid: 12859901
references.citation: J Clin Oncol. 2010 Feb 20;28(6):1075-83
references.pmid: 20085938
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18854-9
references.pmid: 16365287
references.citation: Nat Chem Biol. 2008 Sep;4(9):538-47
references.pmid: 18641634
references.citation: Annu Rev Immunol. 2009;27:591-619
references.pmid: 19132916
references.citation: Biochem Soc Symp. 2007;(74):117-28
references.pmid: 17233585
references.citation: Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17472-7
references.pmid: 23047693
references.citation: J Biol Chem. 2003 Oct 10;278(41):39866-73
references.pmid: 12878591
references.citation: J Biol Chem. 1999 Jul 30;274(31):21589-97
references.pmid: 10419465
references.citation: Biochem Soc Trans. 2012 Feb;40(1):257-61
references.pmid: 22260701
references.citation: J Gen Physiol. 2007 Apr;129(4):267-83
references.pmid: 17389247
references.citation: Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9867-72
references.pmid: 12897244
references.citation: Curr Biol. 2001 Oct 16;11(20):1600-5
references.pmid: 11676921
references.citation: Oncogene. 2004 Feb 26;23(8):1594-8
references.pmid: 14647425
references.citation: Nature. 1984 Nov 22-28;312(5992):315-21
references.pmid: 6095092
references.citation: Nature. 1997 Nov 13;390(6656):192-6
references.pmid: 9367159
references.citation: Nat Cell Biol. 2004 Jun;6(6):487-92
references.pmid: 15170460
references.citation: Mol Cell Biol. 2009 Jan;29(2):342-56
references.pmid: 19015240
references.citation: Curr Biol. 2003 Mar 18;13(6):504-9
references.pmid: 12646134
references.citation: FEBS Lett. 2008 Apr 16;582(9):1391-4
references.pmid: 18364242
references.citation: Sci Signal. 2011 Sep 13;4(190):ra59
references.pmid: 21917715
references.citation: Nat Genet. 2007 Sep;39(9):1134-9
references.pmid: 17676042
references.citation: J Immunol. 2005 Apr 1;174(7):4161-71
references.pmid: 15778376
references.citation: Cell Metab. 2011 Jun 8;13(6):690-700
references.pmid: 21641550
references.citation: Biochemistry. 2005 May 31;44(21):7678-86
references.pmid: 15909982
references.citation: Endocrinology. 2004 Nov;145(11):4853-65
references.pmid: 15284192
references.citation: Nature. 2001 Aug 23;412(6849):826-31
references.pmid: 11518968
references.citation: J Immunol. 2010 Oct 15;185(8):4714-23
references.pmid: 20855869
references.citation: Adv Enzyme Regul. 2005;45:201-14
references.pmid: 16023705
references.citation: Mol Cell Biol. 2002 Apr;22(7):1961-70
references.pmid: 11884585
references.citation: J Biol Chem. 2002 Dec 6;277(49):47276-84
references.pmid: 12270933
references.citation: Trends Immunol. 2001 Sep;22(9):490-6
references.pmid: 11525939
references.citation: Nature. 2002 Aug 22;418(6900):897-900
references.pmid: 12192415
references.citation: FEBS Lett. 2010 Jun 3;584(11):2455-60
references.pmid: 20417634
references.citation: Cell Host Microbe. 2011 Apr 21;9(4):263-72
references.pmid: 21501826
references.citation: Hum Mol Genet. 1998 Oct;7(11):1703-12
references.pmid: 9736772
references.citation: J Biol Chem. 2004 Sep 10;279(37):38590-6
references.pmid: 15247229
references.citation: J Membr Biol. 2003 Jul 15;194(2):77-89
references.pmid: 14502432
references.citation: J Immunol. 2011 Jun 15;186(12):6839-47
references.pmid: 21543646
references.citation: Physiology (Bethesda). 2009 Feb;24:8-16
references.pmid: 19196647
references.citation: EMBO J. 2006 Mar 8;25(5):1024-34
references.pmid: 16482216
references.citation: Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):6049-54
references.pmid: 16585509
references.citation: J Immunol. 2005 Oct 1;175(7):4483-9
references.pmid: 16177091
references.citation: J Immunol. 2001 Jan 1;166(1):387-95
references.pmid: 11123316
references.citation: Nature. 1988 Apr 14;332(6165):644-6
references.pmid: 2833705
references.citation: Biochem J. 2010 May 27;428(3):375-84
references.pmid: 20370717
references.citation: Trends Cell Biol. 2002 Nov;12(11):532-8
references.pmid: 12446115
references.citation: Immunity. 2010 Jun 25;32(6):766-77
references.pmid: 20541955
references.citation: J Biol Chem. 2004 Feb 20;279(8):7304-12
references.pmid: 14660569
references.citation: J Cell Sci. 2009 Jul 15;122(Pt 14):2567-74
references.pmid: 19549683
references.citation: PLoS Genet. 2011 Oct;7(10):e1002319
references.pmid: 22028665
references.citation: Mol Cell Biol. 2005 May;25(9):3630-8
references.pmid: 15831468
references.citation: EMBO Rep. 2013 Jan;14(1):57-64
references.pmid: 23154468
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16834-9
references.pmid: 17940011
references.citation: Nat Med. 2011 Jun;17(6):720-5
references.pmid: 21623381