title: The unfolded protein response triggered by environmental factors.
abstract: Endoplasmic reticulum (ER) stress and consequent unfolded protein response (UPR) are involved in a diverse range of pathologies including ischemic diseases, neurodegenerative disorders, and metabolic diseases, such as diabetes mellitus. The UPR is also triggered by various environmental factors; e.g., pollutants, infectious pathogens, therapeutic drugs, alcohol, physical stress, and malnutrition. This review summarizes current knowledge on environmental factors that induce ER stress and describes how the UPR is linked to particular pathological states after exposure to environmental triggers.
authors.affiliation: Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan. masanori@yamanashi.ac.jp
authors.forename: Masanori
authors.initials: M
authors.lastname: Kitamura
mesh_terms: D000818:Animals; D064420:Drug-Related Side Effects and Adverse Reactions; D059865:Endoplasmic Reticulum Stress; D004777:Environment; D004785:Environmental Pollutants / Q000009:adverse effects; D054884:Host-Pathogen Interactions; D006801:Humans; D044342:Malnutrition / Q000503:physiopathology; D013312:Stress, Physiological; D056811:Unfolded Protein Response / Q000502:physiology
chemical_list: D004785:Environmental Pollutants
references.citation: Life Sci. 2006 Feb 16;78(12):1317-23
references.pmid: 16236328
references.citation: J Am Soc Nephrol. 2004 Feb;15(2):380-9
references.pmid: 14747384
references.citation: Toxicol Sci. 2007 Sep;99(1):346-53
references.pmid: 17567590
references.citation: Cell Microbiol. 2008 Sep;10(9):1775-86
references.pmid: 18433465
references.citation: Am J Physiol Renal Physiol. 2008 Nov;295(5):F1495-503
references.pmid: 18799549
references.citation: Nephron. 1991;58(4):466-71
references.pmid: 1922613
references.citation: Toxicology. 2011 Sep 5;287(1-3):105-12
references.pmid: 21703327
references.citation: Biochem Pharmacol. 2009 Jul 1;78(1):70-7
references.pmid: 19447225
references.citation: Free Radic Biol Med. 2008 Jul 1;45(1):50-9
references.pmid: 18394432
references.citation: J Immunol. 2009 Jul 15;183(2):1480-7
references.pmid: 19561103
references.citation: Mol Pharmacol. 2005 Jun;67(6):1909-19
references.pmid: 15755908
references.citation: Antioxid Redox Signal. 2009 Sep;11(9):2353-64
references.pmid: 19187000
references.citation: Nature. 2008 Jul 24;454(7203):455-62
references.pmid: 18650916
references.citation: Neurotoxicology. 2012 Jun;33(3):290-8
references.pmid: 22342837
references.citation: Apoptosis. 2006 Jan;11(1):5-13
references.pmid: 16374548
references.citation: Gastroenterology. 2010 Jan;138(1):197-209
references.pmid: 19732776
references.citation: J Biol Chem. 1996 Feb 2;271(5):2709-16
references.pmid: 8576245
references.citation: Cell Death Differ. 2006 Mar;13(3):393-403
references.pmid: 16397582
references.citation: Breast Cancer Res Treat. 2010 Nov;124(2):361-75
references.pmid: 20157774
references.citation: Neurotoxicology. 2012 Jun;33(3):545-57
references.pmid: 22370090
references.citation: Free Radic Biol Med. 2000 Jan 1;28(1):46-54
references.pmid: 10656290
references.citation: Cancer Res. 2007 Nov 15;67(22):10920-8
references.pmid: 18006837
references.citation: Mol Cell. 2004 Sep 10;15(5):767-76
references.pmid: 15350220
references.citation: Int J Biochem Cell Biol. 2012 Jan;44(1):224-32
references.pmid: 22064246
references.citation: Am J Respir Crit Care Med. 2009 Dec 15;180(12):1196-207
references.pmid: 19797762
references.citation: FEBS Lett. 1996 Aug 26;392(2):129-36
references.pmid: 8772190
references.citation: Cell Mol Life Sci. 2004 Jul;61(14):1816-25
references.pmid: 15241557
references.citation: Toxicol Appl Pharmacol. 2012 Mar 1;259(2):236-47
references.pmid: 22252055
references.citation: FEBS Lett. 2007 May 15;581(10):2055-9
references.pmid: 17475259
references.citation: PLoS One. 2012;7(5):e38038
references.pmid: 22675432
references.citation: Acta Physiol Scand. 2003 Nov;179(3):273-80
references.pmid: 14616243
references.citation: J Immunol. 2009 Jun 1;182(11):7201-11
references.pmid: 19454717
references.citation: Free Radic Biol Med. 1998 Sep;25(4-5):554-60
references.pmid: 9741592
references.citation: Antioxid Redox Signal. 2004 Oct;6(5):835-40
references.pmid: 15345143
references.citation: Cell Death Differ. 2004 Sep;11(9):1009-16
references.pmid: 15131590
references.citation: Nat Med. 2006 Aug;12(8):908-16
references.pmid: 16862153
references.citation: J Cell Biol. 2004 Feb 2;164(3):341-6
references.pmid: 14757749
references.citation: Discov Med. 2011 Dec;12(67):471-80
references.pmid: 22204764
references.citation: J Am Soc Nephrol. 2010 Jan;21(1):73-81
references.pmid: 19875812
references.citation: Mol Pharmacol. 1994 Nov;46(5):873-9
references.pmid: 7969074
references.citation: Toxicol Appl Pharmacol. 2009 Jan 15;234(2):256-65
references.pmid: 19027770
references.citation: Gastroenterology. 2003 Mar;124(3):708-24
references.pmid: 12612910
references.citation: EMBO J. 2003 Oct 15;22(20):5435-45
references.pmid: 14532116
references.citation: J Clin Invest. 2002 Nov;110(10):1389-98
references.pmid: 12438434
references.citation: Neurotoxicology. 2006 Dec;27(6):1110-22
references.pmid: 16815551
references.citation: Neuromolecular Med. 2008;10(4):333-42
references.pmid: 18773310
references.citation: Toxicol Mech Methods. 2008 Jan;18(9):751-7
references.pmid: 20020935
references.citation: Adv Chronic Kidney Dis. 2006 Jan;13(1):47-55
references.pmid: 16412970
references.citation: J Biol Chem. 2002 May 17;277(20):18077-83
references.pmid: 11877419
references.citation: J Cereb Blood Flow Metab. 2005 Mar;25(3):358-70
references.pmid: 15689959
references.citation: Perit Dial Int. 2011 Jan-Feb;31(1):80-9
references.pmid: 20448242
references.citation: Am J Pathol. 2004 Oct;165(4):1279-88
references.pmid: 15466393
references.citation: J Exp Med. 2004 Jul 5;200(1):35-46
references.pmid: 15226357
references.citation: Arch Insect Biochem Physiol. 1995;29(2):135-57
references.pmid: 7606041
references.citation: Toxicology. 2002 Oct 30;180(1):65-77
references.pmid: 12324200
references.citation: Toxicol Appl Pharmacol. 1995 Oct;134(2):285-95
references.pmid: 7570605
references.citation: Toxicol Sci. 2010 Apr;114(2):378-86
references.pmid: 20071421
references.citation: Cell Microbiol. 2008 Mar;10(3):770-80
references.pmid: 18005243
references.citation: Trends Biochem Sci. 2001 Aug;26(8):504-10
references.pmid: 11504627
references.citation: J Biol Chem. 2008 Feb 15;283(7):4252-60
references.pmid: 18086661
references.citation: Toxicol Lett. 2011 Feb 25;201(1):15-26
references.pmid: 21145380
references.citation: J Clin Microbiol. 2005 Jun;43(6):2944-7
references.pmid: 15956427
references.citation: Toxicol Appl Pharmacol. 2011 Aug 1;254(3):311-22
references.pmid: 21601586
references.citation: FEBS J. 2007 Feb;274(3):630-58
references.pmid: 17288551
references.citation: J Am Soc Nephrol. 2003 Dec;14(12):3072-80
references.pmid: 14638906
references.citation: Mol Biol Rep. 2012 Apr;39(4):3987-93
references.pmid: 21779805
references.citation: Environ Health Perspect. 1985 Dec;64:111-26
references.pmid: 3007083
references.citation: Antioxid Redox Signal. 2007 Dec;9(12):2277-93
references.pmid: 17979528
references.citation: J Nutr. 2005 Nov;135(11):2530-4
references.pmid: 16251606
references.citation: J Clin Invest. 2005 Oct;115(10):2656-64
references.pmid: 16200199
references.citation: Environ Toxicol. 2006 Dec;21(6):621-2; author reply 622
references.pmid: 17091507
references.citation: Biochem Res Int. 2012;2012:216450
references.pmid: 22110961
references.citation: Neurotox Res. 2001 Nov;3(6):581-9
references.pmid: 15111246
references.citation: Cell Death Differ. 2007 Aug;14(8):1467-74
references.pmid: 17464326
references.citation: Blood Purif. 1989;7(2-3):74-85
references.pmid: 2663038
references.citation: Apoptosis. 2009 Nov;14(11):1366-77
references.pmid: 19771520
references.citation: Nephrol Dial Transplant. 2012 Nov;27(11):4053-60
references.pmid: 22573236
references.citation: PLoS One. 2011;6(8):e23740
references.pmid: 21876766
references.citation: J Immunol. 2009 Jan 15;182(2):1182-91
references.pmid: 19124762
references.citation: Toxicology. 2009 Jul 28;262(1):57-64
references.pmid: 19460413
references.citation: Mol Cancer Res. 2005 Nov;3(11):597-605
references.pmid: 16317085
references.citation: Toxicol Sci. 2000 Sep;57(1):156-66
references.pmid: 10966522
references.citation: Toxicology. 2003 Feb 1;183(1-3):211-20
references.pmid: 12504352
references.citation: Nature. 2006 Oct 5;443(7111):548-52
references.pmid: 17024087
references.citation: J Biochem. 2010 Apr;147(4):471-83
references.pmid: 19919955
references.citation: Toxicology. 2012 Jun 14;296(1-3):37-47
references.pmid: 22434021
references.citation: Toxicology. 2009 Oct 29;264(3):215-24
references.pmid: 19720107
references.citation: Mol Cell Biol. 2004 Feb;24(3):1365-77
references.pmid: 14729979
references.citation: FEBS Lett. 2006 Jan 9;580(1):9-14
references.pmid: 16343492
references.citation: Toxicol Appl Pharmacol. 2009 Jan 1;234(1):14-24
references.pmid: 18951912
references.citation: Cancer. 2002 Sep 1;95(5):1113-9
references.pmid: 12209698
references.citation: Invest New Drugs. 2000 May;18(2):109-21
references.pmid: 10857991
references.citation: Toxicol Lett. 2009 Dec 15;191(2-3):203-10
references.pmid: 19735704
references.citation: Mol Cell Biol. 2011 Apr;31(8):1710-8
references.pmid: 21300786
references.citation: Cell Death Differ. 2006 Mar;13(3):374-84
references.pmid: 16397578
references.citation: Biochemistry. 1992 Sep 8;31(35):8300-6
references.pmid: 1525167
references.citation: Cell Struct Funct. 2012;37(1):49-53
references.pmid: 22251794
references.citation: Curr Mol Med. 2006 Feb;6(1):55-69
references.pmid: 16472113
references.citation: Am J Med Sci. 2007 Aug;334(2):115-24
references.pmid: 17700201
references.citation: J Biol Chem. 2002 Apr 5;277(14):11780-7
references.pmid: 11781318
references.citation: Nephron Physiol. 2003;93(4):p87-93
references.pmid: 12759569
references.citation: J Nutr. 2005 May;135(5):978-82
references.pmid: 15867268
references.citation: Int J Radiat Biol. 2013 Aug;89(8):656-67
references.pmid: 22788682
references.citation: Part Fibre Toxicol. 2010 Dec 03;7(1):39
references.pmid: 21126379
references.citation: Nucleic Acids Res. 2006 Jul 28;34(13):e93
references.pmid: 16877567
references.citation: Toxicol Sci. 2002 Sep;69(1):265-78
references.pmid: 12215682
references.citation: Environ Health Perspect. 2006 Jun;114(6):859-64
references.pmid: 16759985
references.citation: Free Radic Res. 1996 Apr;24(4):243-59
references.pmid: 8731009
references.citation: Inflamm Res. 2012 Nov;61(11):1265-72
references.pmid: 22825625
references.citation: Nat Genet. 2003 Oct;35(2):171-5
references.pmid: 12949534
references.citation: J Biochem. 2005 Oct;138(4):501-7
references.pmid: 16272146
references.citation: J Immunol. 2009 Jul 15;183(2):1368-74
references.pmid: 19553530
references.citation: J Biol Chem. 2000 Jan 21;275(3):1887-96
references.pmid: 10636889
references.citation: Biochem Biophys Res Commun. 2010 Jun 25;397(2):350-4
references.pmid: 20513357
references.citation: Chemosphere. 2012 Apr;87(4):423-34
references.pmid: 22245057
references.citation: Mol Cell Biochem. 2003 Jun;248(1-2):41-7
references.pmid: 12870653
references.citation: Biochem Biophys Res Commun. 2005 Nov 4;336(4):1136-43
references.pmid: 16168956
references.citation: Mol Cancer Ther. 2008 Jul;7(7):1940-8
references.pmid: 18645004
references.citation: Mol Cell Biol. 2000 Oct;20(19):7192-204
references.pmid: 10982836
references.citation: Cell Microbiol. 2012 Jan;14(1):1-9
references.pmid: 21899699
references.citation: J Am Soc Nephrol. 2005 Jul;16(7):1985-92
references.pmid: 15901768
references.citation: Neuroscience. 2007 Feb 9;144(3):1045-56
references.pmid: 17137721
references.citation: Toxicol In Vitro. 2007 Aug;21(5):878-86
references.pmid: 17416481
references.citation: Int Rev Immunol. 2011 Feb;30(1):4-15
references.pmid: 21235322
references.citation: Bipolar Disord. 2002 Apr;4(2):145-51
references.pmid: 12071512