title: α-Palladation of imines as entry to dehydrogenative Heck reaction: aerobic oxidative cyclization of N-allylimines to pyrroles.
abstract: We report here a palladium(II)-catalyzed oxidative cyclization reaction of N-allylimines derived from methyl ketones, typically acetophenones, affording pyrrole derivatives at room temperature under oxygen atmosphere. The reaction likely proceeds through α-palladation of the imine followed by olefin migratory insertion and β-hydride elimination, thus representing a new example of aerobic dehydrogenative Heck cyclization.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Chen
authors.forename: Beili
authors.initials: B
authors.lastname: Lu
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Ding
authors.forename: Ke
authors.initials: K
authors.lastname: Gao
authors.forename: Naohiko
authors.initials: N
authors.lastname: Yoshikai