title: Larvicidal activity of lipophilic extract of Hypericum carinatum (Clusiaceae) against Aedes aegypti (Diptera: Culicidae) and benzophenones determination.
abstract: In this study, the larvicidal activity of an enriched fraction of the major lipophilic phenolic compounds from Hypericum carinatum Griseb. (Clusiaceae) was investigated against larvae of Aedes aegypti (Diptera: Culicidae), the main vector of dengue virus in Brazil. The larval mortality rate ranged 37.33 to 72.00 % at concentrations of 66-200 μg/mL. The effect demonstrated to be dose-dependent. The lethal concentration 50 % and confidence interval were 100 and 88-111 μg/mL, respectively. The results could be attributed to the presence of cariphenone A and cariphenone B in concentrations of 1.24 ± 0.04 and 0.56 ± 0.01 %, respectively, determined by high-performance liquid chromatography. Besides, the results reinforce the potential of genus Hypericum as source of alternative insecticides.
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Flavia Corvello
authors.initials: FC
authors.lastname: da Silva
authors.forename: Francisco Maikon Corrêa
authors.initials: FM
authors.lastname: de Barros
authors.forename: Josiane Somariva
authors.initials: JS
authors.lastname: Prophiro
authors.forename: Onilda Santos
authors.initials: OS
authors.lastname: da Silva
authors.forename: Thiago Nunes
authors.initials: TN
authors.lastname: Pereira
authors.forename: Sérgio A
authors.initials: SA
authors.lastname: de Loreto Bordignon
authors.forename: Vera Lucia
authors.initials: VL
authors.lastname: Eifler-Lima
authors.forename: Gilsane Lino
authors.initials: GL
authors.lastname: von Poser
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D001577:Benzophenones / Q000032:analysis* / Q000494:pharmacology; D001681:Biological Assay; D001938:Brazil; D020902:Hypericum / Q000737:chemistry*; D007303:Insect Vectors; D007306:Insecticides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D016019:Survival Analysis
chemical_list: D001577:Benzophenones; D007306:Insecticides; D010936:Plant Extracts; C501806:cariphenone A; C501807:cariphenone B
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