title: Structural basis of eukaryotic cell targeting by type III secretion system (T3SS) effectors.
abstract: Type III secretion systems (T3SS) are macromolecular complexes that translocate a wide number of effector proteins into eukaryotic host cells. Once within the cytoplasm, many T3SS effectors mimic the structure and/or function of eukaryotic proteins in order to manipulate signaling cascades, and thus play pivotal roles in colonization, invasion, survival and virulence. Structural biology techniques have played key roles in the unraveling of bacterial strategies employed for mimicry and targeting. This review provides an overall view of our current understanding of structure and function of T3SS effectors, as well as of the different classes of eukaryotic proteins that are targeted and the consequences for the infected cell.
authors.affiliation: Bacterial Pathogenesis Group, Institut de Biologie Structurale (IBS), Université Grenoble I, 41 rue Jules Horowitz, 38027 Grenoble, France.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Tosi
authors.forename: Alexander
authors.initials: A
authors.lastname: Pflug
authors.forename: Karen F
authors.initials: KF
authors.lastname: Discola
authors.forename: David
authors.initials: D
authors.lastname: Neves
authors.forename: Andréa
authors.initials: A
authors.lastname: Dessen
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D010447:Peptide Hydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D055571:Secretory Pathway
chemical_list: D011506:Proteins; D010447:Peptide Hydrolases
keywords: Bacterial infection; Crystallography; Effectors; Signaling; Structure; T3SS