title: Association between miR-146a rs2910164 polymorphism and autoimmune diseases susceptibility: a meta-analysis.
abstract: Published data on the rs2910164 in microRNA-146a (miR-146a) are shown to be associated with increased or decreased autoimmune diseases risk. To derive a more precise estimation of the relationship, we performed a meta-analysis to systematically summarize the possible. A meta-analysis including 11 studies with 3042 controls and 2197 cases was performed for genotypes CC (recessive effect), CC+CG (dominant effect) and C allele in fixed or random-effects models based on between-study heterogeneity. Overall, no significant association between miR-146a G/C rs2910164 polymorphism and autoimmune diseases risk was found in all genetic models when all studies were pooled into the meta-analysis. SLE (OR=0.99, 95% CI: 0.90-1.10), RA (OR=0.98, 95% CI: 0.85-1.14) did not yield statistical significance as for C allele pooled studies. In the subgroup analysis by ethnicity, still no significant association was detected in all genetic models. Our meta-analysis suggests that there is no association between miR-146a G/C rs2910164 polymorphism and the development of autoimmune diseases.
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China.
authors.forename: Hui Fang
authors.initials: HF
authors.lastname: Chen
authors.forename: Ting Ting
authors.initials: TT
authors.lastname: Hu
authors.forename: Xue Yan
authors.initials: XY
authors.lastname: Zheng
authors.forename: Mei Qing
authors.initials: MQ
authors.lastname: Li
authors.forename: Min Hong
authors.initials: MH
authors.lastname: Luo
authors.forename: Yue Xian
authors.initials: YX
authors.lastname: Yao
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.forename: Shou Yi
authors.initials: SY
authors.lastname: Yu
mesh_terms: D000483:Alleles; D001327:Autoimmune Diseases / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs