title: Associations of prenatal exposure to phenols with birth outcomes.
abstract: Many phenols are known to mimic or antagonize hormonal activities and may adversely affect fetal growth. A study of 567 pregnant women was conducted to investigate the relationship between prenatal phenol exposure and birth outcomes, including birth weight, length, and gestational age. We measured the concentrations of bisphenol A, benzophenone-3, 4-n-octylphenol and 4-n-nonylphenol in maternal urine and examine their association with birth outcomes. Categories of urinary benzophenone-3 concentration were associated with decreased gestational age in all infants (p for trend = 0.03). Between middle and low exposure groups, we also found bisphenol A was negatively associated with gestational duration (βadjusted = -0.48 week; 95% confidence interval: -0.91, -0.05). After stratification by gender, we found the consistent results in infant boys with those in all infants, but we did not observe significant association for girls. In conclusion, we found prenatal phenol exposure was sex-specifically related to birth outcomes.
authors.affiliation: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, 818 East Tianyuan Road, Nanjing 211166, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Tang
authors.forename: Min-Jian
authors.initials: MJ
authors.lastname: Chen
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Ding
authors.forename: Xiao-Jiao
authors.initials: XJ
authors.lastname: Chen
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Han
authors.forename: Kun
authors.initials: K
authors.lastname: Zhou
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Chen
authors.forename: Yan-Kai
authors.initials: YK
authors.lastname: Xia
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.forename: Xin-Ru
authors.initials: XR
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D004785:Environmental Pollutants / Q000652:urine*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008297:Male; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D008875:Middle Aged; D010636:Phenols / Q000652:urine*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D010636:Phenols