title: Breast ultrasound in 22,131 asymptomatic women with negative mammography.
abstract: OBJECTIVE
  To evaluate increment cancer detection rate generated by ultrasound (US).
  
  
  METHODS
  US only detected cancers were assessed for 22,131 self-referring asymptomatic women with negative mammography and subgroups by age, previous cancer, breast density. Invasive assessment and surgical biopsy rate were evaluated.
  
  
  RESULTS
  The overall US detection was 1.85 per thousand (41/22,131). In the subgroups it was: 1.95 per thousand (22/11,274) in women <50 years vs 1.75 per thousand (19/10,857) in women ≥ 50 years (p = 0.42), 5.49 per thousand (12/2183) in women with previous cancer vs 1.45 per thousand (29/19,948) in women without cancer history (p = 0.0004), 2.21 per thousand (22/9960) in dense breasts (p = 0.17) vs 1.56 per thousand (19/12,171) in fatty breasts. The US generated invasive assessment was 1.9% (422/22,131). The benign to malignant open surgical biopsy ratio was 0.17 (7/41).
  
  
  CONCLUSIONS
  Adding US to negative mammography allowed for substantial incremental cancer detection rate (1.85 per thousand), particularly at age <50 years, in women with previous breast cancer and in dense breasts.
authors.affiliation: Diagnostic Breast Clinic, Casa di Cura Dott. Pederzoli, Peschiera del Garda, Italy. Electronic address: dott.veronicagirardi@gmail.com.
authors.forename: Veronica
authors.initials: V
authors.lastname: Girardi
authors.forename: Mara
authors.initials: M
authors.lastname: Tonegutti
authors.forename: Stefano
authors.initials: S
authors.lastname: Ciatto
authors.forename: Franco
authors.initials: F
authors.lastname: Bonetti
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D058070:Asymptomatic Diseases; D001706:Biopsy; D001940:Breast / Q000473:pathology*; D000071060:Breast Density; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D042361:Mammary Glands, Human / Q000002:abnormalities; D008327:Mammography; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D016217:Ultrasonography, Mammary / Q000706:statistics & numerical data*
keywords: Breast neoplasm; Mammography; Screening; Ultrasonography