title: Cross-talk between GPER and growth factor signaling.
abstract: G protein-coupled receptors (GPCRs) and growth factor receptors mediate multiple physio-pathological responses to a diverse array of extracellular stimuli. In this regard, it has been largely demonstrated that GPCRs and growth factor receptors generate a multifaceted signaling network, which triggers relevant biological effects in normal and cancer cells. For instance, some GPCRs transactivate the epidermal growth factor receptor (EGFR), which stimulates diverse transduction pathways leading to gene expression changes, cell migration, survival and proliferation. Moreover, it has been reported that a functional interaction between growth factor receptors and steroid hormones like estrogens is involved in the growth of many types of tumors as well as in the resistance to endocrine therapy. This review highlights recent findings on the cross-talk between a member of the GPCR family, the G protein-coupled estrogen receptor 1 (GPER, formerly known as GPR30) and two main growth factor receptors like EGFR and insulin-like growth factor-I receptor (IGF-IR). The biological implications of the functional interaction between these important mediators of cell responses particularly in cancer are discussed. This article is part of a Special Issue entitled 'CSR 2013'.
authors.affiliation: Dipartimento Farmaco-Biologico, Università della Calabria, via P. Bucci, 87036 Rende, Italy.
authors.forename: Rosamaria
authors.initials: R
authors.lastname: Lappano
authors.forename: Paola
authors.initials: P
authors.lastname: De Marco
authors.forename: Ernestina Marianna
authors.initials: EM
authors.lastname: De Francesco
authors.forename: Adele
authors.initials: A
authors.lastname: Chimento
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pezzi
authors.forename: Marcello
authors.initials: M
authors.lastname: Maggiolini
mesh_terms: D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008024:Ligands; D020239:Receptor Cross-Talk; D011960:Receptors, Estrogen / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C109584:GPER1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled
keywords: Cancer; EGFR; Estrogen; GPR30/GPER; Growth factor signaling; IGF-IR