title: Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products.
abstract: The advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs) contribute to the development of diabetic complications and of other pathologies. The review discusses the possibilities of counteracting the formation and stimulating the degradation of these species by pharmaceuticals and natural compounds. The review discusses inhibitors of ALE and AGE formation, cross-link breakers, ALE/AGE elimination by enzymes and proteolytic systems, receptors for advanced glycation end products (RAGEs) and blockade of the ligand-RAGE axis.
authors.affiliation: Department of Pharmaceutical Sciences, University of Milan, Milan, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Aldini
authors.forename: Giulio
authors.initials: G
authors.lastname: Vistoli
authors.forename: Milan
authors.initials: M
authors.lastname: Stefek
authors.forename: N
authors.initials: N
authors.lastname: Chondrogianni
authors.forename: Tilman
authors.initials: T
authors.lastname: Grune
authors.forename: Jolanta
authors.initials: J
authors.lastname: Sereikaite
authors.forename: Izabela
authors.initials: I
authors.lastname: Sadowska-Bartosz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Bartosz
mesh_terms: D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D003432:Cross-Linking Reagents / Q000378:metabolism / Q000494:pharmacology; D048909:Diabetes Complications / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects / Q000378:metabolism; D059748:Proteolysis / Q000187:drug effects; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism
chemical_list: D000975:Antioxidants; D003432:Cross-Linking Reagents; D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D046988:Proteasome Endopeptidase Complex