title: IgE- and IgG mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria.
abstract: BACKGROUND
  Allergic reactions occur commonly in transfusion practice. However, severe anaphylactic reactions are rare; anti-IgA (IgA: Immunoglobulin A) in IgA-deficient patients is one of the well-illustrated and reported causes for such reactions. However, IgE-mediated hypersensitivity reaction through blood component transfusion may be caused in parasitic hyperimmunization for IgG and IgE antibodies.
  
  
  METHODS
  We have evaluated here a severe anaphylactic transfusion reaction retrospectively in an 18year-old male, a known case of cerebral malaria, developed after platelet transfusions. The examination and investigations revealed classical signs and symptoms of anaphylaxis along with a significant rise in the serum IgE antibody level and IgG by hemagglutination method. Initial mild allergic reaction was followed by severe anaphylactic reaction after the second transfusion of platelets.
  
  
  CONCLUSIONS
  Based on these results, screening of patients and donors with mild allergic reactions to IgE antibodies may help in understanding the pathogenesis as well as in planning for preventive desensitization and measures for safe transfusion.
authors.affiliation: Department of Transfusion Medicine, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Andhra Pradesh, India.
authors.forename: B
authors.initials: B
authors.lastname: Shanthi
authors.lastname: Bhavanadhar
authors.forename: Priscilla
authors.initials: P
authors.lastname: Chandran
authors.forename: A Krishna
authors.initials: AK
authors.lastname: Prasad
keywords: Anaphylactic transfusion reaction; IgE mediated allergic transfusion reaction; investigation of transfusion reaction; platelet transfusion reactions
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