title: Amyloid-β interacts with blood-brain barrier function in dementia: a systematic review.
abstract: To date, the exact pathogenesis of dementia is still unknown. The most frequently hypothesized initiating factor is an accumulation of the protein amyloid-β in the brain, which has been associated with dementia of the Alzheimer type. Another potentially important initiating factor is a disrupted blood-brain barrier. This can initiate cerebral microangiopathy, which has frequently been associated with vascular dementia. Although amyloid-β and blood-brain barrier dysfunction have both been associated with one particular type of dementia (Alzheimer's disease and vascular dementia, respectively), they co-exist in most demented patients. In fact, increasing evidence indicates that amyloid-β and blood-brain barrier disruption may interact and facilitate each other in their effect on neurodegeneration. The present systematic analysis describes the available evidence for a significant interplay between amyloid-β and blood-brain barrier function in dementia.
authors.affiliation: Department of Psychiatry and Neuropsychology/Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands. s.burgmans@maastrichtuniversity.nl
authors.forename: Saartje
authors.initials: S
authors.lastname: Burgmans
authors.forename: Harm J
authors.initials: HJ
authors.lastname: van de Haar
authors.forename: Frans R J
authors.initials: FR
authors.lastname: Verhey
authors.forename: Walter H
authors.initials: WH
authors.lastname: Backes
mesh_terms: D016229:Amyloid beta-Peptides / Q000502:physiology*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000473:pathology*; D001921:Brain / Q000473:pathology; D002448:Cell Adhesion / Q000502:physiology; D003627:Data Interpretation, Statistical; D003704:Dementia / Q000473:pathology*; D004727:Endothelium / Q000473:pathology; D006801:Humans; D009000:Monocytes / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor