title: [The preventive effect of flurbiprofen on preventing mesenteric traction syndrome].
abstract: BACKGROUND
  Mesenteric traction syndrome (MTS) is associated with facial flushing, hypotension and tachycardia. The ways to treat MTS are fluid replacement, administration of vasopressors and nonsteroidal anti-inflammatory drugs (NSAIDs) such as flurbiprofen. In order to stabilize the hemodynamics during operation, preventing MTS is more reasonable. Thus, we investigated the preventive effect of flurbiprofen on MTS, the only injectable formulation which can be used in Japan.
  
  
  METHODS
  In a prospective randomized study, 24 patients undergoing elective colorectal surgery were assigned to two groups. In one group (n = 11 group F), flurbiprofen (1 mg x kg(-1), 50 mg max) was administered before surgery. In the second group (n = 13; group C), flurbiprofen was not administered. After laparotomy, presence of facial flushing and blood pressure reduction were compared. MTS is defined as facial flushing with concomitant blood pressure reduction.
  
  
  RESULTS
  MTS occurred in no patients in group F, but in 11 patients in group C (84.6%, P < 0.05). In cases of the patients in which MTS appeared, facial flushing was observed at 5.9 +/- 5.2 min after starting mesenteric manipulation, and the mean reduction in blood pressure was 40.3% at 9.9 +/- 4.4 min after starting mesenteric manipulation.
  
  
  CONCLUSIONS
  Our results indicate that pretreatment with flurbiprofen might prevent MTS.
authors.affiliation: Department of Anesthesiology, Metropolitan Bokutoh Hospital, Tokyo 130-8575.
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Takahashi
authors.forename: Dai
authors.initials: D
authors.lastname: Shida
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tagawa
authors.forename: Takeo
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D005260:Female; D005480:Flurbiprofen / Q000627:therapeutic use*; D005483:Flushing / Q000517:prevention & control*; D006801:Humans; D007022:Hypotension / Q000517:prevention & control*; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D011446:Prospective Studies; D013577:Syndrome; D013610:Tachycardia / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005480:Flurbiprofen