title: [Evaluation of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of hilar and mediastinal tumors].
abstract: OBJECTIVE
  To explore the diagnostic values of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with hilar and mediastinal tumors.
  
  
  METHODS
  A total of 837 patients with chest CT or PET/CT confirmed mediastinal/hilar lymphadenopathy and or tumors in (or around) the trachea or bronchi, were evaluated by EBUS-TBNA examination. Pathological study or follow-up visit was carried out in the same period to make a final diagnosis, and therefore to verify the accuracy of EBUS-TBNA.
  
  
  RESULTS
  The study punctured 1631 lymph nodes totally, with an average of 1.95 times per case. The 4R group and the 7th group of lymph nodes accounted for 43% and 34%, respectively. The success rate of TBNA was 100%. The diagnosis rates of lung cancer was 94.11%, of which squamous cell carcinoma accounted for 19.22% (89 cases), adenocarcinoma 32.40% (150 cases), small cell carcinoma 23.54% (109 cases), non-small cell carcinoma of unknown histological type 9.50% (44 cases), adenosquamous carcinoma 7.56% (35 cases), and other types 7.78% (36 cases). The diagnosis rate of tuberculosis was 85.50%, and that of sarcoidosis was 55.88%. The overall sensitivity of EBUS-TBNA was 94.02%, specificity 100%, positive predictive value 100%, negative predictive value 61.91%, and the accuracy was 94.56%. Besides mild bleeding in the puncture site, no other complications occurred, and there were no severe complications such as pneumothorax, pneumomediastinum, or major vascular injury.
  
  
  CONCLUSIONS
  EBUS-TBNA is of high value as a minimally invasive, convenient, and low-risk procedure for the diagnosis of mediastinal and hilar lymphadenopathy and tumors.
authors.affiliation: Tongji University Medical School, Shanghai, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Gu
authors.forename: Ge-ning
authors.initials: GN
authors.lastname: Jiang
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhou
authors.forename: Hong-bin
authors.initials: HB
authors.lastname: Jianhg
authors.forename: Sheng-xiang
authors.initials: SX
authors.lastname: Ren
authors.forename: Ai-wu
authors.initials: AW
authors.lastname: Li
authors.forename: Hai-ping
authors.initials: HP
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000379:methods*; D001980:Bronchi / Q000000981:diagnostic imaging; D001999:Bronchoscopy; D019160:Endosonography; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008482:Mediastinum / Q000473:pathology; D008875:Middle Aged; D055815:Young Adult