title: Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity.
abstract: Mammalian cells can express up to four different class I phosphatidylinositide 3-kinase (PI3K) isoforms, each of which is engaged by tyrosine kinases or G protein-coupled receptors (GPCRs) to generate the second messenger signaling molecule PtdIns(3,4,5)P₃ (PIP₃). The p110α and p110β isoforms are relatively widely expressed, whereas p110γ and p110δ are more highly expressed in cells of the immune system than in other cell types. Nevertheless, each of the four class I PI3Ks have been shown to participate in the orchestration of the signaling events that lead to immune cell development and control of gene expression, skewing toward individual cell lineage subsets and proliferation.
authors.affiliation: Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Cambridge, United Kingdom. Klaus.okkenhaug@babraham.ac.uk
authors.forename: Klaus
authors.initials: K
authors.lastname: Okkenhaug
mesh_terms: D000818:Animals; D055162:Biocatalysis; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D058534:Class I Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D007109:Immunity; D007527:Isoenzymes / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D007527:Isoenzymes; D018129:Phosphatidylinositol Phosphates; D043562:Receptors, G-Protein-Coupled; C060974:phosphatidylinositol 3,4,5-triphosphate; D058534:Class I Phosphatidylinositol 3-Kinases
references.citation: J Immunol. 2010 Oct 1;185(7):4042-52
references.pmid: 20826752
references.citation: Sci Signal. 2010 Aug 10;3(134):ra60
references.pmid: 20699475
references.citation: Blood. 2010 Mar 18;115(11):2203-13
references.pmid: 20081091
references.citation: J Immunol. 2004 Aug 15;173(4):2236-40
references.pmid: 15294934
references.citation: Blood. 2008 Feb 1;111(3):1464-71
references.pmid: 18006698
references.citation: J Exp Med. 2010 Jan 18;207(1):247-61
references.pmid: 20038597
references.citation: Science. 2002 Aug 9;297(5583):1031-4
references.pmid: 12130661
references.citation: J Immunol. 2006 Oct 15;177(8):5122-8
references.pmid: 17015696
references.citation: Sci Signal. 2011 Apr 12;4(168):ra23
references.pmid: 21487106
references.citation: Blood. 2005 Aug 15;106(4):1432-40
references.pmid: 15878979