title: [Three-year efficacy and side effect of adefovir dipivoxil for the treatment of the old patients with chronic hepatitis B virus infection].
abstract: OBJECTIVE
  To investigate 3-year antiviral efficacy and side effect of adefovir dipivoxil (ADV) on the old patients with hepatitis B chronic infection.
  
  
  METHODS
  31 HBeAg-negative chronic hepatitis B virus infected old patients (include 8 patients with chronic hepatitis B and 23 patients with liver cirrhosis) with serum HBV DNA levels > 1000 copies/ml, and ALT > 2 times the upper limit of normal, without company with other liver diseases, cancer, renal dysfunction, and autoimmune disease. All the patients were treated with ADV orally (10 mg once daily) for 36 months. HBV DNA and biochemical and blood routine indexes were checked after treated.
  
  
  RESULTS
  Serum total bilirubin, direct bilirubin, alamine aminotransferase, aspartate aminotransferase and load of HBV DNA decrease significantly after therapy (P < 0. 001). Other biochemical indexs and blood routine are no significant changes (P > 0.05).
  
  
  CONCLUSIONS
  The way to treat with ADV is safe and effective for old patients with chronic hepatitis B virus infection.
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors.forename: Meng-Fei
authors.initials: MF
authors.lastname: Zhu
authors.forename: Jian-Cheng
authors.initials: JC
authors.lastname: Qian
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.forename: Feng-Le
authors.initials: FL
authors.lastname: Yan
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Shi
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Lou
mesh_terms: D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D000225:Adenine; C106812:adefovir dipivoxil