title: ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity.
abstract: We investigated the relationship of apoB/apoA1 ratio and coronary heart disease (CHD) in persons who were overweight or obese. The subjects were divided by the body mass indexes (BMI) into the normal weight group (n=397, BMI<24 kg/m(2)) and the overweight group (n=400, BMI>24 kg/m(2)). Our results showed that the over-weight group had higher blood pressure [(130.15±19.01) mmHg vs (123.66±18.70) mmHg] and higher levels of blood sugar [(7.09±2.89) mmol/L vs (6.21±2.59) mmol/L], triglyceride [(1.93±1.19) mmol/L vs (1.44±0.85) mmol/L], total cholesterol [(4.26±1.06) mmol/L vs (4.09±0.99) mmol/L], low-density lipoprotein cholesterol (LDL-C) [(2.56±0.75) mmol/L vs (2.39±0.72) mmol/L], and apoB [(0.83±0.27) mg/L vs (0.78±0.23) mg/L], and a higher apoB/apoA1 ratio (0.83±0.27 vs 0.75±0.25) and lower levels high-density lipoprotein cholesterol [(1.10±0.26) mmol/L vs (1.21±0.31) mmol/L] and apoA1 [(1.04±0.20) mg/L vs (1.08±0.22) mg/L] than those of the normal weight group (all P < 0.05). The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the lowest apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve (AUC) was the highest for apoB/apoA1 (0.655). The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.forename: Qun
authors.initials: Q
authors.lastname: Lu
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Tian
keywords: apoB/apoA1 ratio; coronary heart disease; obesity; overweight
references.citation: Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1287-98
references.pmid: 19342510
references.citation: J Intern Med. 2004 Feb;255(2):188-205
references.pmid: 14746556
references.citation: Circulation. 2008 Mar 25;117(12):1563-73
references.pmid: 18332268
references.citation: Exerc Immunol Rev. 2004;10:66-74
references.pmid: 15633587
references.citation: Arterioscler Thromb Vasc Biol. 2006 May;26(5):968-76
references.pmid: 16627822
references.citation: Diabetologia. 2007 Aug;50(8):1770-9
references.pmid: 17579831
references.citation: J Intern Med. 2006 May;259(5):481-92
references.pmid: 16629854
references.citation: Curr Atheroscler Rep. 2008 Oct;10(5):377-85
references.pmid: 18706278
references.citation: Curr Opin Cardiol. 2010 Nov;25(6):622-6
references.pmid: 20852414
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2126-31
references.pmid: 16452169
references.citation: J Intern Med. 2006 Mar;259(3):247-58
references.pmid: 16476102
references.citation: Diabetes Obes Metab. 2007 May;9(3):218-32
references.pmid: 17391148
references.citation: Eur Heart J. 2009 Mar;30(6):710-7
references.pmid: 18676970
references.citation: Atherosclerosis. 2010 Nov;213(1):299-305
references.pmid: 20843515
references.citation: Curr Cardiol Rep. 2009 Nov;11(6):468-75
references.pmid: 19863872
references.citation: Vasc Health Risk Manag. 2009;5:793-9
references.pmid: 19812691
references.citation: Am J Cardiol. 2004 Jan 15;93(2):136-41
references.pmid: 14715336
references.citation: Am Heart J. 2010 Feb;159(2):292-300
references.pmid: 20152229
references.citation: Atherosclerosis. 2010 Oct;212(2):392-7
references.pmid: 20609437
references.citation: J Gerontol A Biol Sci Med Sci. 2006 Dec;61(12):1262-6
references.pmid: 17234819
references.citation: Eur Heart J. 2010 Jan;31(2):222-6
references.pmid: 19687163
references.citation: J Intern Med. 2006 May;259(5):434-6
references.pmid: 16629848
references.citation: Nutr Metab Cardiovasc Dis. 2007 Oct;17(8):565-71
references.pmid: 17631989
references.citation: Eur Heart J. 2009 Sep;30(17):2137-46
references.pmid: 19520708
references.citation: Lancet. 2001 Dec 15;358(9298):2026-33
references.pmid: 11755609
references.citation: N Engl J Med. 2005 Jan 6;352(1):29-38
references.pmid: 15635110
references.citation: Int J Obes (Lond). 2010 Feb;34(2):340-7
references.pmid: 19918249
references.citation: Metabolism. 2004 Jul;53(7):852-7
references.pmid: 15254876
references.citation: Circ J. 2009 May;73(5):878-84
references.pmid: 19282609