title: [Effect of angiotensin converting enzyme lisinopril on the state of vascular bed in premenopausal women with arterial hypertension].
abstract: We assessed effect of lisinopril on structural-functional state of vascular bed in 82 premenopausal women with hypoestrogenia and arterial hypertension (AH). Test with postocclusion reactive hyperemia showed that at the background of significant lowering of endothelial vasomotor function before treatment 47.5% of women had inertial type of vasomotor reaction. This evidenced for considerable role of dyshormonal states in progression of AH first of all at the account of increase of vascular stiffness and development of endothelial dysfunction. Lisinopril improved structural-functional state of vascular wall of common carotid arteries, affected positively dysfunction of endothelium, lowered stiffness of arterial vascular wall.
authors.forename: M M
authors.initials: MM
authors.lastname: Khabibulina
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors; D001794:Blood Pressure / Q000187:drug effects*; D016903:Drug Monitoring; D004727:Endothelium / Q000378:metabolism / Q000503:physiopathology; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D006940:Hyperemia / Q000209:etiology; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D017706:Lisinopril / Q000008:administration & dosage / Q000378:metabolism; D008875:Middle Aged; D017697:Premenopause / Q000187:drug effects / Q000378:metabolism; D016896:Treatment Outcome; D059289:Vascular Stiffness / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D017706:Lisinopril