title: Bilateral pallidal stimulation for Wilson's disease.
abstract: BACKGROUND
  To report on the clinical efficacy of bilateral globus pallidus internus deep brain stimulation in a 29-year-old patient with severe generalized dystonia secondary to Wilson's disease.
  
  
  METHODS
  The primary outcome measure was the Burke-Fahn-Marsden Dystonia Scale motor severity score (blinded assessment) and the secondary outcome measures were the Abnormal Involuntary Movement Scale (blinded assessment) and the Zaritt Caregiver Burden Interview score, at 20-week postoperative follow up.
  
  
  RESULTS
  There was a 14% improvement in the Burke-Fahn-Marsden Dystonia Scale motor severity score. Abnormal Involuntary Movement Scale score remained unchanged while the Zaritt Caregiver Burden Interview score improved by 44.4%.
  
  
  CONCLUSIONS
  Bilateral globus pallidus deep brain stimulation can be effective in ameliorating dystonia and caregiver burden in Wilson's disease. Outcomes may depend on the stage of the disease at which the surgical procedure is completed. © 2013 Movement Disorder Society.
authors.affiliation: Toronto Western Hospital, Toronto, Ontario, Canada. csidiro1@hfhs.org
authors.forename: Christos
authors.initials: C
authors.lastname: Sidiropoulos
authors.forename: William
authors.initials: W
authors.lastname: Hutchison
authors.forename: Tiago
authors.initials: T
authors.lastname: Mestre
authors.forename: Elena
authors.initials: E
authors.lastname: Moro
authors.forename: Ian A
authors.initials: IA
authors.lastname: Prescott
authors.forename: Alejandro Valencia
authors.initials: AV
authors.lastname: Mizrachi
authors.forename: Melanie
authors.initials: M
authors.lastname: Fallis
authors.forename: Anand I
authors.initials: AI
authors.lastname: Rughani
authors.forename: Suneil K
authors.initials: SK
authors.lastname: Kalia
authors.forename: Andres
authors.initials: A
authors.lastname: Lozano
authors.forename: Susan
authors.initials: S
authors.lastname: Fox
mesh_terms: D000328:Adult; D046690:Deep Brain Stimulation / Q000379:methods*; D005917:Globus Pallidus / Q000502:physiology*; D006527:Hepatolenticular Degeneration / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012720:Severity of Illness Index; D016896:Treatment Outcome
keywords: Wilson's disease; deep brain stimulation; globus pallidus