title: Nickel-catalyzed cycloaddition of vinylcyclopropanes to imines.
abstract: Nickel-catalyzed intermolecular [3 + 2] cycloaddition of vinylcyclopropanes to imines has been developed. This transformation generates substituted pyrrolidines in high yields, with good regio- and diastereo- selectivity under mild reaction conditions. A variety of imines can be used in this reaction. An asymmetric variant of the reaction has also been demonstrated.
authors.affiliation: Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
authors.forename: Rihoko
authors.initials: R
authors.lastname: Tombe
authors.forename: Takuya
authors.initials: T
authors.lastname: Kurahashi
authors.forename: Seijiro
authors.initials: S
authors.lastname: Matsubara
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D061565:Cycloaddition Reaction; D003521:Cyclopropanes / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003521:Cyclopropanes; D007097:Imines; D011759:Pyrrolidines; D009532:Nickel