title: Post-transcriptional regulatory networks in immunity.
abstract: Post-transcriptional mechanisms that modulate global and/or transcript-specific mRNA stability and translation contribute to the rapid and flexible control of gene expression in immune effector cells. These mechanisms rely on RNA-binding proteins (RBPs) that direct regulatory complexes (e.g. exosomes, deadenylases, decapping complexes, RNA-induced silencing complexes) to the 3'-untranslated regions of specific immune transcripts. Here, we review the surprising variety of post-transcriptional control mechanisms that contribute to gene expression in the immune system and discuss how defects in these pathways can contribute to autoimmune disease.
authors.affiliation: Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA. pivanov@rics.bwh.harvard.edu
authors.forename: Pavel
authors.initials: P
authors.lastname: Ivanov
authors.forename: Paul
authors.initials: P
authors.lastname: Anderson
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D005786:Gene Expression Regulation / Q000235:genetics / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D034622:RNA Interference / Q000276:immunology*; D016601:RNA-Binding Proteins / Q000276:immunology*
chemical_list: D020413:3' Untranslated Regions; D016601:RNA-Binding Proteins
references.citation: Eur J Immunol. 1989 May;19(5):843-7
references.pmid: 2500347
references.citation: EMBO J. 1998 Jun 15;17(12):3448-60
references.pmid: 9628880
references.citation: Cell. 2008 Mar 7;132(5):860-74
references.pmid: 18329371
references.citation: Mol Cell Biol. 2006 Nov;26(22):8228-41
references.pmid: 16954375
references.citation: Mol Cell Biol. 2002 Mar;22(6):1664-73
references.pmid: 11865046
references.citation: J Immunol. 2009 Aug 15;183(4):2506-12
references.pmid: 19625646
references.citation: Mol Cell Biol. 2011 Aug;31(16):3196-207
references.pmid: 21690298
references.citation: Immunol Rev. 2008 Apr;222:206-21
references.pmid: 18364004
references.citation: J Exp Med. 2007 May 14;204(5):971-7
references.pmid: 17470640
references.citation: Mol Cell. 2011 Aug 5;43(3):327-39
references.pmid: 21723170
references.citation: Cancer Res. 2001 Mar 1;61(5):2154-61
references.pmid: 11280780
references.citation: Mol Cell. 2011 Aug 5;43(3):340-52
references.pmid: 21723171
references.citation: Mol Cell Biol. 2002 Mar;22(6):1742-53
references.pmid: 11865054
references.citation: Gastroenterology. 2007 Mar;132(3):1055-65
references.pmid: 17383427
references.citation: Mol Cell Biol. 1999 Oct;19(10):6898-905
references.pmid: 10490627
references.citation: Eur J Biochem. 2004 Feb;271(3):648-60
references.pmid: 14728692
references.citation: Cell. 1997 May 16;89(4):597-606
references.pmid: 9160751
references.citation: Nature. 2008 Mar 20;452(7185):323-8
references.pmid: 18272964
references.citation: Nat Immunol. 2006 Jun;7(6):644-51
references.pmid: 16680145
references.citation: Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19961-6
references.pmid: 21041655
references.citation: PLoS Biol. 2008 Apr 29;6(4):e111
references.pmid: 18447585
references.citation: Genomics. 1998 Mar 1;48(2):195-202
references.pmid: 9521873
references.citation: FEBS J. 2009 Dec;276(24):7386-99
references.pmid: 19909337
references.citation: J Biol Chem. 2005 Feb 18;280(7):5750-63
references.pmid: 15548538
references.citation: J Biol Chem. 1995 Dec 1;270(48):28995-9003
references.pmid: 7499432
references.citation: J Immunol. 2005 Apr 15;174(8):5047-56
references.pmid: 15814736
references.citation: Nature. 1988 Jan 28;331(6154):356-8
references.pmid: 2893286
references.citation: J Immunol. 1999 Oct 15;163(8):4199-206
references.pmid: 10510356
references.citation: Nature. 1994 May 19;369(6477):239-42
references.pmid: 8183344
references.citation: Biochim Biophys Acta. 1986 Dec 22;864(3-4):471-95
references.pmid: 3098292
references.citation: Science. 1998 Jun 19;280(5371):1945-9
references.pmid: 9632395
references.citation: Wiley Interdiscip Rev RNA. 2010 Nov-Dec;1(3):432-56
references.pmid: 21956941
references.citation: FEBS Lett. 2012 Jan 2;586(1):41-6
references.pmid: 22138182
references.citation: Proc Natl Acad Sci U S A. 1990 Jan;87(2):777-81
references.pmid: 2105489
references.citation: EMBO J. 1998 Jun 15;17(12):3461-70
references.pmid: 9628881
references.citation: RNA. 2001 Nov;7(11):1578-88
references.pmid: 11720287
references.citation: J Biol Chem. 2007 Oct 12;282(41):30070-7
references.pmid: 17711853
references.citation: Mol Cell Biol. 2003 Mar;23(5):1509-19
references.pmid: 12588972
references.citation: J Immunol. 2009 Jun 1;182(11):6779-88
references.pmid: 19454673
references.citation: Mol Cell Biol. 2005 Aug;25(15):6533-45
references.pmid: 16024790
references.citation: Immunity. 2005 May;22(5):633-42
references.pmid: 15894280
references.citation: EMBO J. 2007 Dec 12;26(24):5020-32
references.pmid: 18034160
references.citation: J Immunol. 2006 Dec 1;177(11):8095-102
references.pmid: 17114484
references.citation: J Biol Chem. 2005 Oct 14;280(41):34609-16
references.pmid: 16109718
references.citation: Mol Cell Biol. 1991 May;11(5):2460-6
references.pmid: 1901943
references.citation: Mol Cell Biol. 2002 Dec;22(23):8114-21
references.pmid: 12417715
references.citation: EMBO J. 2008 Mar 5;27(5):736-47
references.pmid: 18256688
references.citation: J Immunol. 2001 Nov 15;167(10):5970-6
references.pmid: 11698476
references.citation: Nat Rev Mol Cell Biol. 2008 Apr;9(4):337-44
references.pmid: 18334997
references.citation: Proc Natl Acad Sci U S A. 1986 Mar;83(6):1670-4
references.pmid: 2419912
references.citation: Mol Cell. 2002 Dec;10(6):1331-44
references.pmid: 12504009
references.citation: Curr Opin Cell Biol. 2009 Jun;21(3):394-402
references.pmid: 19359157
references.citation: Nucleic Acids Res. 1991 Feb 25;19(4):917-20
references.pmid: 2017372
references.citation: Genes Dev. 2001 Sep 15;15(18):2321-42
references.pmid: 11562344
references.citation: J Biol Chem. 2002 May 24;277(21):18489-93
references.pmid: 11889124
references.citation: EMBO J. 1999 Sep 15;18(18):4969-80
references.pmid: 10487749
references.citation: J Clin Invest. 1990 Jan;85(1):121-9
references.pmid: 1688564
references.citation: Science. 2002 Nov 8;298(5596):1241-5
references.pmid: 12424381
references.citation: Nucleic Acids Res. 1993 Jun 11;21(11):2761-6
references.pmid: 8332472
references.citation: J Clin Invest. 1997 Sep 1;100(5):986-95
references.pmid: 9276715
references.citation: Nat Struct Mol Biol. 2009 Jan;16(1):49-55
references.pmid: 19060897
references.citation: Cell. 2007 Mar 23;128(6):1105-18
references.pmid: 17382880
references.citation: Eur J Immunol. 2006 Oct;36(10):2745-54
references.pmid: 16983723
references.citation: J Biol Chem. 2008 Apr 25;283(17):11689-99
references.pmid: 18256032
references.citation: J Immunol. 2007 Jul 15;179(2):918-27
references.pmid: 17617583
references.citation: Trends Immunol. 2013 Mar;34(3):137-43
references.pmid: 23103127
references.citation: Nature. 2009 Apr 30;458(7242):1185-90
references.pmid: 19322177
references.citation: J Immunol. 2004 Jul 15;173(2):976-85
references.pmid: 15240685
references.citation: Science. 1998 Aug 14;281(5379):1001-5
references.pmid: 9703499
references.citation: BMC Immunol. 2010 Jan 11;11:1
references.pmid: 20064252
references.citation: Mol Cell Biol. 2006 Apr;26(7):2716-27
references.pmid: 16537914
references.citation: J Clin Invest. 2007 Sep;117(9):2570-82
references.pmid: 17710230
references.citation: J Clin Invest. 2001 Dec;108(11):1657-65
references.pmid: 11733561
references.citation: Mol Cell Biol. 2007 Dec;27(23):8388-400
references.pmid: 17908789
references.citation: J Immunol. 2006 Nov 15;177(10):6999-7006
references.pmid: 17082615
references.citation: Mol Cell Biol. 1995 Apr;15(4):2219-30
references.pmid: 7891716
references.citation: Biochem Soc Trans. 2008 Jun;36(Pt 3):491-6
references.pmid: 18481987
references.citation: J Biol Chem. 1994 Oct 7;269(40):25178-84
references.pmid: 7523380
references.citation: Nucleic Acids Res. 2005 Aug 26;33(15):4813-27
references.pmid: 16126846
references.citation: J Biol Chem. 2003 Jan 17;278(3):1579-84
references.pmid: 12426321
references.citation: EMBO J. 2002 Sep 2;21(17):4709-18
references.pmid: 12198173
references.citation: Proc Natl Acad Sci U S A. 1983 Jul;80(13):3923-7
references.pmid: 6575385
references.citation: Nat Rev Immunol. 2009 May;9(5):324-37
references.pmid: 19390566
references.citation: Mol Cell Biol. 2001 Oct;21(19):6440-9
references.pmid: 11533233
references.citation: Mol Cell Biol. 2003 Sep;23(18):6685-93
references.pmid: 12944492
references.citation: J Immunol. 2008 Feb 15;180(4):2545-52
references.pmid: 18250465
references.citation: Nucleic Acids Res. 2012 Aug;40(14):6957-65
references.pmid: 22561375
references.citation: Genes Dev. 2011 Oct 15;25(20):2119-24
references.pmid: 22012617
references.citation: Int J Cancer. 2005 Apr 20;114(4):598-605
references.pmid: 15578697
references.citation: Nucleic Acids Res. 2002 Jul 15;30(14):3052-8
references.pmid: 12136087
references.citation: Cell. 2003 Oct 17;115(2):187-98
references.pmid: 14567916
references.citation: Nat Immunol. 2012 Apr 29;13(6):543-550
references.pmid: 22544393
references.citation: Mol Cell Biol. 2012 Jan;32(1):107-17
references.pmid: 22037763
references.citation: Immunity. 1996 May;4(5):445-54
references.pmid: 8630730
references.citation: Mol Cell Biol. 2010 Aug;30(16):3970-80
references.pmid: 20547756
references.citation: Mol Cell Biol. 2003 Jan;23(2):510-25
references.pmid: 12509450
references.citation: RNA. 2006 May;12(5):883-93
references.pmid: 16556936
references.citation: Mol Cell. 2007 Mar 9;25(5):765-78
references.pmid: 17349961
references.citation: Cell. 2005 Mar 11;120(5):623-34
references.pmid: 15766526
references.citation: J Allergy Clin Immunol. 2008 Apr;121(4):853-9.e4
references.pmid: 18279945
references.citation: Science. 1999 Apr 16;284(5413):499-502
references.pmid: 10205060
references.citation: Biochem J. 2004 Jul 15;381(Pt 2):503-10
references.pmid: 15046617
references.citation: Cell. 2004 Oct 15;119(2):195-208
references.pmid: 15479637
references.citation: Cell. 2006 Jun 16;125(6):1111-24
references.pmid: 16777601
references.citation: J Cell Biochem. 2007 Apr 15;100(6):1477-92
references.pmid: 17133347
references.citation: Mol Cell. 2000 Aug;6(2):269-79
references.pmid: 10983975
references.citation: EMBO J. 1985 Feb;4(2):351-9
references.pmid: 3926482
references.citation: Nat Immunol. 2009 Mar;10(3):281-8
references.pmid: 19198593
references.citation: Nature. 2009 Jun 18;459(7249):1010-4
references.pmid: 19458619
references.citation: Proc Natl Acad Sci U S A. 1990 Oct;87(20):7799-803
references.pmid: 2172963
references.citation: J Immunol. 1999 Apr 1;162(7):4037-44
references.pmid: 10201926
references.citation: Cell. 2010 Aug 6;142(3):368-74
references.pmid: 20691898
references.citation: FASEB J. 2009 Sep;23(9):2898-908
references.pmid: 19423639
references.citation: Immunity. 2012 Jul 27;37(1):25-33
references.pmid: 22840841
references.citation: Wiley Interdiscip Rev RNA. 2010 Nov-Dec;1(3):474-85
references.pmid: 21956943
references.citation: Ann Rheum Dis. 2004 Mar;63(3):310-7
references.pmid: 14962968
references.citation: J Immunol. 1990 Aug 1;145(3):840-5
references.pmid: 2197329
references.citation: J Invest Dermatol. 2009 Mar;129(3):657-70
references.pmid: 18830269
references.citation: Mol Biol Cell. 1999 Apr;10(4):907-19
references.pmid: 10198046
references.citation: Nature. 2007 Nov 8;450(7167):299-303
references.pmid: 18172933
references.citation: Semin Immunol. 2011 Apr;23(2):99-105
references.pmid: 21288737
references.citation: Mol Cell Biol. 1991 Mar;11(3):1754-8
references.pmid: 1996120
references.citation: J Biol Chem. 2003 Sep 19;278(38):36157-62
references.pmid: 12855701
references.citation: J Immunol. 2006 Jun 1;176(11):6752-61
references.pmid: 16709834
references.citation: EMBO J. 1996 Nov 1;15(21):5965-75
references.pmid: 8918474
references.citation: Mol Cell. 2004 Jun 4;14(5):571-83
references.pmid: 15175153
references.citation: Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13721-5
references.pmid: 8943001
references.citation: J Immunol. 2006 Oct 1;177(7):4426-35
references.pmid: 16982877
references.citation: EMBO J. 2007 Jul 25;26(14):3360-72
references.pmid: 17611605
references.citation: Trends Immunol. 2007 Dec;28(12):551-8
references.pmid: 17981503
references.citation: Mol Cell Biol. 2011 Apr;31(7):1419-31
references.pmid: 21245386
references.citation: Nat Struct Mol Biol. 2005 Dec;12(12):1054-63
references.pmid: 16284618
references.citation: Front Biosci (Landmark Ed). 2012 Jan 01;17:189-205
references.pmid: 22201738
references.citation: J Exp Med. 2003 Aug 4;198(3):475-81
references.pmid: 12885872
references.citation: Blood. 2009 Sep 17;114(12):2401-10
references.pmid: 19633199
references.citation: Blood. 2001 Oct 15;98(8):2389-95
references.pmid: 11588035
references.citation: EMBO J. 2002 Dec 2;21(23):6505-14
references.pmid: 12456657
references.citation: Adv Nutr. 2012 May 01;3(3):307-21
references.pmid: 22585904
references.citation: Mol Cell Biol. 1994 Dec;14(12):7984-95
references.pmid: 7969138
references.citation: J Biol Chem. 2008 Sep 12;283(37):25606-25616
references.pmid: 18640985
references.citation: Genes Dev. 2000 May 15;14(10):1236-48
references.pmid: 10817758
references.citation: Med Res Rev. 2001 May;21(3):185-210
references.pmid: 11301410
references.citation: J Biol Chem. 1998 Mar 13;273(11):6417-23
references.pmid: 9497373
references.citation: Wiley Interdiscip Rev RNA. 2010 Nov-Dec;1(3):457-73
references.pmid: 21956942
references.citation: Development. 2004 Oct;131(19):4883-93
references.pmid: 15342461
references.citation: J Biol Chem. 2002 Feb 1;277(5):3065-8
references.pmid: 11741878
references.citation: Trends Biochem Sci. 1995 Nov;20(11):465-70
references.pmid: 8578590
references.citation: Annu Rev Immunol. 2012;30:295-312
references.pmid: 22224773
references.citation: Genes Dev. 2005 Feb 1;19(3):351-61
references.pmid: 15687258
references.citation: Mol Cell Biol. 2006 Apr;26(8):3295-307
references.pmid: 16581801
references.citation: J Vasc Res. 2009;46(1):36-44
references.pmid: 18515973
references.citation: RNA. 2007 Sep;13(9):1453-68
references.pmid: 17626845
references.citation: Biol Chem. 2003 Jan;384(1):25-37
references.pmid: 12674497
references.citation: Mol Cell Biol. 2003 May;23(10):3506-15
references.pmid: 12724409
references.citation: J Immunol. 2010 Sep 15;185(6):3190-8
references.pmid: 20720200
references.citation: Nucleic Acids Res. 2012 Dec;40(22):11531-44
references.pmid: 23066106
references.citation: PLoS Biol. 2008 Apr 29;6(4):e92
references.pmid: 18447580
references.citation: Biochem Biophys Res Commun. 2006 Jul 21;346(1):160-8
references.pmid: 16759646
references.citation: Mol Cell. 2003 Jan;11(1):113-26
references.pmid: 12535526
references.citation: Mol Cell Biol. 2000 Jun;20(11):3753-63
references.pmid: 10805719
references.citation: Trends Biochem Sci. 2009 Jul;34(7):324-31
references.pmid: 19535251
references.citation: EMBO J. 2000 Aug 1;19(15):4154-63
references.pmid: 10921895
references.citation: J Interferon Cytokine Res. 2008 Nov;28(11):679-91
references.pmid: 18844578
references.citation: Nat Immunol. 2008 Oct;9(10):1157-64
references.pmid: 18758466
references.citation: Wiley Interdiscip Rev RNA. 2011 Mar-Apr;2(2):193-208
references.pmid: 21957006
references.citation: Nat Cell Biol. 2009 Sep;11(9):1157-63
references.pmid: 19701194
references.citation: J Immunol. 2000 Oct 15;165(8):4478-86
references.pmid: 11035087
references.citation: Genes Dev. 2006 Nov 15;20(22):3174-84
references.pmid: 17085481
references.citation: EMBO J. 2001 Sep 3;20(17):4987-97
references.pmid: 11532962
references.citation: Cell Mol Life Sci. 2010 Mar;67(5):677-700
references.pmid: 19859661
references.citation: Mol Cell Biol. 2007 Jan;27(1):283-96
references.pmid: 17074806
references.citation: Cell. 2005 Jan 14;120(1):15-20
references.pmid: 15652477
references.citation: Mol Cell Biol. 1997 Jul;17(7):3898-906
references.pmid: 9199324
references.citation: Am J Physiol Gastrointest Liver Physiol. 2003 Sep;285(3):G529-38
references.pmid: 12760902
references.citation: Nat Immunol. 2005 Dec;6(12):1280-7
references.pmid: 16273101
references.citation: J Biol Chem. 2003 Dec 19;278(51):51758-69
references.pmid: 14523003
references.citation: Blood. 2005 Jan 1;105(1):282-8
references.pmid: 15345584
references.citation: Wiley Interdiscip Rev RNA. 2011 Mar-Apr;2(2):167-83
references.pmid: 21957004
references.citation: Nat Rev Immunol. 2006 Jan;6(1):44-55
references.pmid: 16493426
references.citation: Mol Cell Biol. 2004 Jul;24(14):6445-55
references.pmid: 15226444
references.citation: J Immunol. 2005 Jan 15;174(2):953-61
references.pmid: 15634918
references.citation: Mol Immunol. 2008 Apr;45(7):1995-2006
references.pmid: 18061676
references.citation: Science. 2007 Dec 21;318(5858):1931-4
references.pmid: 18048652
references.citation: Nat Chem Biol. 2012 Feb 12;8(3):311-7
references.pmid: 22327401
references.citation: J Biol Chem. 2000 Jun 9;275(23):17827-37
references.pmid: 10751406
references.citation: Genes Dev. 2008 Jan 1;22(1):50-65
references.pmid: 18172165
references.citation: Cell Mol Life Sci. 2008 Oct;65(20):3168-81
references.pmid: 18581050
references.citation: Nat Immunol. 2010 Aug;11(8):725-33
references.pmid: 20639877
references.citation: Cell. 2001 Jan 26;104(2):281-90
references.pmid: 11207368
references.citation: Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4844-9
references.pmid: 10781090
references.citation: Mol Cell Biol. 2006 May;26(10):3695-706
references.pmid: 16648466
references.citation: Clin Immunol Immunopathol. 1989 Sep;52(3):421-34
references.pmid: 2758698
references.citation: Cell. 1996 May 3;85(3):415-22
references.pmid: 8616896
references.citation: Mol Cell. 2009 Jul 31;35(2):164-80
references.pmid: 19647514
references.citation: Mol Immunol. 2007 Jan;44(4):434-42
references.pmid: 16584775
references.citation: FEBS J. 2010 May;277(9):2109-27
references.pmid: 20412057
references.citation: Immunity. 1999 Mar;10(3):387-98
references.pmid: 10204494
references.citation: Genes Dev. 2009 Aug 1;23(15):1743-8
references.pmid: 19574298
references.citation: Nat Rev Mol Cell Biol. 2005 Apr;6(4):318-27
references.pmid: 15803138
references.citation: Mol Cell Biol. 2009 May;29(10):2762-76
references.pmid: 19307312
references.citation: J Immunol. 1988 Apr 1;140(7):2267-73
references.pmid: 3258333
references.citation: Mol Cell Biol. 2009 Jan;29(2):458-70
references.pmid: 19001086
references.citation: Nat Genet. 2004 Oct;36(10):1073-8
references.pmid: 15448691
references.citation: PLoS One. 2012;7(1):e28907
references.pmid: 22253700
references.citation: Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14134-9
references.pmid: 20679199
references.citation: Blood. 2006 Jun 15;107(12):4790-7
references.pmid: 16514065
references.citation: Mol Cell. 2007 Jan 12;25(1):113-26
references.pmid: 17218275
references.citation: Mol Cell Biol. 2008 Jan;28(1):93-107
references.pmid: 17967866
references.citation: Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7029-36
references.pmid: 11416183
references.citation: Cell. 1986 Aug 29;46(5):659-67
references.pmid: 3488815
references.citation: J Immunol. 2003 Jan 15;170(2):979-88
references.pmid: 12517964
references.citation: Front Biosci (Landmark Ed). 2011 Jan 01;16:1787-96
references.pmid: 21196264
references.citation: Mol Cell Biol. 1988 Aug;8(8):3432-8
references.pmid: 2463477
references.citation: Cytokine. 1991 Nov;3(6):551-61
references.pmid: 1686413
references.citation: Mol Cell Biol. 1995 Oct;15(10):5777-88
references.pmid: 7565731
references.citation: Adv Exp Med Biol. 2011;780:15-26
references.pmid: 21842361
references.citation: Nature. 2009 Feb 12;457(7231):915-9
references.pmid: 19098893
references.citation: Science. 2009 Jun 5;324(5932):1334-8
references.pmid: 19498172
references.citation: Blood. 2000 Mar 15;95(6):1891-9
references.pmid: 10706852
references.citation: Immunity. 1998 Feb;8(2):135-41
references.pmid: 9491995
references.citation: Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2011-6
references.pmid: 14769925
references.citation: Am J Pathol. 1999 Apr;154(4):1149-58
references.pmid: 10233853
references.citation: Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11572-7
references.pmid: 21709220
references.citation: J Clin Invest. 2012 Jan;122(1):48-61
references.pmid: 22201685
references.citation: Int Immunopharmacol. 2003 Sep;3(9):1247-55
references.pmid: 12890422
references.citation: J Immunol. 2010 May 1;184(9):5009-17
references.pmid: 20357261
references.citation: J Immunol. 2008 Sep 1;181(5):3336-45
references.pmid: 18714005
references.citation: J Biol Chem. 1995 Jun 16;270(24):14597-603
references.pmid: 7782323
references.citation: EMBO J. 1994 Oct 3;13(19):4617-22
references.pmid: 7925302
references.citation: J Immunol. 2003 Oct 15;171(8):4369-78
references.pmid: 14530362
references.citation: PLoS Pathog. 2012;8(5):e1002702
references.pmid: 22615562
references.citation: RNA. 2006 Jun;12(6):1084-91
references.pmid: 16601207
references.citation: Nat Immunol. 2008 Apr;9(4):353-9
references.pmid: 18349815
references.citation: J Exp Med. 1990 Feb 1;171(2):465-75
references.pmid: 2303781
references.citation: Mol Cell. 2008 Feb 1;29(2):263-70
references.pmid: 18243120
references.citation: Ann N Y Acad Sci. 2003 Dec;1010:504-9
references.pmid: 15033780
references.citation: J Biol Chem. 2004 Feb 27;279(9):8196-205
references.pmid: 14662769
references.citation: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D111-4
references.pmid: 16381826
references.citation: Eur J Immunol. 2009 Aug;39(8):2224-32
references.pmid: 19572319
references.citation: J Biol Chem. 2004 Apr 2;279(14):13354-62
references.pmid: 14726527
references.citation: J Immunol. 2006 Feb 15;176(4):2105-13
references.pmid: 16455966
references.citation: J Biol Chem. 1996 Apr 12;271(15):8747-53
references.pmid: 8621509
references.citation: J Biol Chem. 1994 Nov 18;269(46):28591-7
references.pmid: 7961806
references.citation: Mol Cell. 2005 Sep 16;19(6):777-89
references.pmid: 16168373