title: PEG mediated synthesis and pharmacological evaluation of some fluoro substituted pyrazoline derivatives as antiinflammatory and analgesic agents.
abstract: A new series of fluoro substituted pyrazoline derivatives 5a-g and 6a-g were synthesized in good to excellent yield from the corresponding pyrazole chalcones, 4a-g, by using polyethylene glycol-400 (PEG-400) as an alternative reaction medium. The newly synthesized compounds were characterized and screened for their in vivo antiinflammatory and analgesic activity. Compounds 5g and 6g were found to be more potent than standard drug Diclofenac and six other compounds 5b, 5c, 5f, 6b, 6c and 6f showed significant antiinflammatory activity as compared to standard drug. Compounds 5c, 5d, 5e, 5f, 6c, 6d, 6e and 6f showed significant analgesic activity as compared to standard drug Aspirin.
authors.affiliation: Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413255, Maharashtra, India.
authors.forename: Shravan Y
authors.initials: SY
authors.lastname: Jadhav
authors.forename: Sachin P
authors.initials: SP
authors.lastname: Shirame
authors.forename: Suresh D
authors.initials: SD
authors.lastname: Kulkarni
authors.forename: Sandeep B
authors.initials: SB
authors.lastname: Patil
authors.forename: Sharad K
authors.initials: SK
authors.lastname: Pasale
authors.forename: Raghunath B
authors.initials: RB
authors.lastname: Bhosale
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005461:Fluorine / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013623:Tail / Q000187:drug effects
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011720:Pyrazoles; D005461:Fluorine; C031280:pyrazole; D011092:Polyethylene Glycols