title: Granulocyte-colony stimulating factor-producing cervical cancers treated with carbon-ion irradiation.
abstract: Granulocyte-colony stimulating factor (G-CSF)-producing tumor is a rare condition. It has an aggressive nature and shows resistance to conventional treatments. We report two cases of G-CSF-producing uterine cervical cancer who were successfully treated with carbon-ion radiotherapy (C-ion RT). The first case was a 76-year-old woman with stage IIIB uterine cervical cancer, and the second was a 75-year-old woman with bulky stage IIB disease. Prior to treatment, both patients presented severe granulocytosis and elevated serum G-CSF concentrations. After C-ion RT, their cervical tumors completely disappeared, and their granulocytosis and elevated serum G-CSF levels improved as well. C-ion RT has been reported to be effective for various aggressive tumors, and it may be a good treatment option for this rare aggressive tumor.
authors.affiliation: Department of Radiology, Saitama Cancer Center, Ina, Kita-adachi, Saitama, Japan. ohkuboy@med.gunma-u.ac.jp
authors.forename: Yu
authors.initials: Y
authors.lastname: Ohkubo
authors.forename: Shingo
authors.initials: S
authors.lastname: Kato
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kiyohara
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kamada
mesh_terms: D000368:Aged; D002244:Carbon / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood / Q000378:metabolism*; D063193:Heavy Ion Radiotherapy; D006801:Humans; D009363:Neoplasm Proteins / Q000097:blood / Q000378:metabolism*; D009367:Neoplasm Staging; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D009363:Neoplasm Proteins; D016179:Granulocyte Colony-Stimulating Factor; D002244:Carbon